Sun May 15 22:21:32 EDT 2022
$PROBLEM    PK
;@ Variables 17/20 @;
$INPUT      ROW ID NOMTIME TIME EVID CMT AMT DV FLAG STUDY BLQ CYCLE
            DOSE PART PROFDAY PROFTIME WEIGHTB eff0
$DATA      xgxr1.csv IGNORE=@ IGNORE=(FLAG.NE.0)
$SUBROUTINE ADVAN4 TRANS4
$PK
TVKA=THETA(1)
TVV2=THETA(2)
TVCL=THETA(3)
TVV3=THETA(4)
TVQ=THETA(5)
                   
KA=TVKA*EXP(ETA(1))
V2=TVV2*EXP(ETA(2))
CL=TVCL*EXP(ETA(3))
V3=TVV3*EXP(ETA(4))
Q=TVQ*EXP(ETA(5))

$ERROR
  IPRED=F
  IRES=DV-IPRED

  IF (IPRED.GT.1) THEN
    W = SQRT(IPRED**2*SIGMA(1,1)**2 + SIGMA(2,2)**2)
  ELSE
    W=1
  ENDIF

  IWRES=IRES/W
  Y=F+F*ERR(1)+ERR(2)

;-----------------------INITIAL ESTIMATES---------------------------------
$THETA  (0,0.9) ; POPKA
$THETA  (0,4.2) ; POPCL
$THETA  (0,3.6) ; POPV2
$THETA  (0,5.81) ; POPV3
$THETA  (0,3.44) ; POPQ
$OMEGA  0.1
$OMEGA  0.1
$OMEGA  0.1
$OMEGA  0  FIX
$OMEGA  0  FIX
$SIGMA  .2
$SIGMA  .2
$ESTIMATION METHOD=1 POSTHOC INTER MAXEVAL=9999 NSIG=2 SIGL=9 PRINT=10
            NOABORT
$TABLE      ROW TVKA TVV2 TVCL TVV3 TVQ KA V2 CL V3 Q PRED IPRED
            NOPRINT FILE=xgxr001_res.txt


