TY - CPAPER T1 - Effects of Aging Pathophysiology on Drug Disposition and Effect T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822385; 6340401 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Abernethy, Darrell Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Aging KW - Disposition KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Effects+of+Aging+Pathophysiology+on+Drug+Disposition+and+Effect&rft.au=Abernethy%2C+Darrell&rft.aulast=Abernethy&rft.aufirst=Darrell&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Regulatory Perspectives on TQT Studies and Alternative Approaches to Assess TdP Risk T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822217; 6340357 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Stockbridge, Norman Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Regulatory+Perspectives+on+TQT+Studies+and+Alternative+Approaches+to+Assess+TdP+Risk&rft.au=Stockbridge%2C+Norman&rft.aulast=Stockbridge&rft.aufirst=Norman&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Bioequivalence Standards for Narrow Therapeutic Index (NTI) Drugs: Are They Stringent Enough to Ensure Safety and Efficacy? T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822161; 6340336 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Fang, Lanyan Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Safety KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Bioequivalence+Standards+for+Narrow+Therapeutic+Index+%28NTI%29+Drugs%3A+Are+They+Stringent+Enough+to+Ensure+Safety+and+Efficacy%3F&rft.au=Fang%2C+Lanyan&rft.aulast=Fang&rft.aufirst=Lanyan&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Where Are We Headed with Evidence of Efectiveness: A Regulatory Perspective T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821892; 6340297 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Temple, Robert Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pharmacology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Where+Are+We+Headed+with+Evidence+of+Efectiveness%3A+A+Regulatory+Perspective&rft.au=Temple%2C+Robert&rft.aulast=Temple&rft.aufirst=Robert&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Efective Oral Presentations T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821860; 6340299 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Uhl, Kathleen Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pharmacology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Efective+Oral+Presentations&rft.au=Uhl%2C+Kathleen&rft.aulast=Uhl&rft.aufirst=Kathleen&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Regulatory Experience on Approval of ADCs T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821142; 6340360 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Schrieber, Sarah Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pharmacology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Regulatory+Experience+on+Approval+of+ADCs&rft.au=Schrieber%2C+Sarah&rft.aulast=Schrieber&rft.aufirst=Sarah&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Impact of Altered in Vitro Dissolution Profile on Warfarin in Vivo Pharmacokinetics Performance- Population Physiologically Based Pharmacokinetic (PBPK) Simulation. T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821108; 6340439 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Fan, J AU - Zhang, X AU - Lionberger, R Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Physiology KW - Dissolution KW - Simulation KW - Warfarin KW - Ecosystem disturbance KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Impact+of+Altered+in+Vitro+Dissolution+Profile+on+Warfarin+in+Vivo+Pharmacokinetics+Performance-+Population+Physiologically+Based+Pharmacokinetic+%28PBPK%29+Simulation.&rft.au=Fan%2C+J%3BZhang%2C+X%3BLionberger%2C+R&rft.aulast=Fan&rft.aufirst=J&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Biomarkers and Pharmacometrics in Drug Development: A Regulatory Perspective T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821025; 6340342 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Marathe, Dhananjay Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Bioindicators KW - Drug development KW - Biomarkers KW - biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Biomarkers+and+Pharmacometrics+in+Drug+Development%3A+A+Regulatory+Perspective&rft.au=Marathe%2C+Dhananjay&rft.aulast=Marathe&rft.aufirst=Dhananjay&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - What are the Regulatory Expectations for Dose Selection of Biologics T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821013; 6340322 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Zhao, Hong Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pharmacology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=What+are+the+Regulatory+Expectations+for+Dose+Selection+of+Biologics&rft.au=Zhao%2C+Hong&rft.aulast=Zhao&rft.aufirst=Hong&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Exposure Response Analysis as Evidence for Approval of Canagliflozin-Metformin Immediate Release Fixed-Dose Combination Product: A Regulatory Perspective. T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820969; 6340337 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Marathe, Anshu Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Response analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Exposure+Response+Analysis+as+Evidence+for+Approval+of+Canagliflozin-Metformin+Immediate+Release+Fixed-Dose+Combination+Product%3A+A+Regulatory+Perspective.&rft.au=Marathe%2C+Anshu&rft.aulast=Marathe&rft.aufirst=Anshu&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Milestones: Sex-Related Insights from Post-Marketing Data T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820810; 6340350 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Kim, Myong-Jin Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Milestones%3A+Sex-Related+Insights+from+Post-Marketing+Data&rft.au=Kim%2C+Myong-Jin&rft.aulast=Kim&rft.aufirst=Myong-Jin&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Pharmacogenetics and Racial Composition in Clinical Trials for Non-Small Cell Lung Cancer and Chronic Hepatitis C Infection. T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820805; 6340308 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Ramamoorthy, A AU - Bull, J AU - Zhang, L AU - Pacanowski, M Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Chronic infection KW - Non-small cell lung carcinoma KW - Hepatitis C KW - Infection KW - Clinical trials KW - Pharmacogenetics KW - Lung cancer KW - Hepatitis C virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Pharmacogenetics+and+Racial+Composition+in+Clinical+Trials+for+Non-Small+Cell+Lung+Cancer+and+Chronic+Hepatitis+C+Infection.&rft.au=Ramamoorthy%2C+A%3BBull%2C+J%3BZhang%2C+L%3BPacanowski%2C+M&rft.aulast=Ramamoorthy&rft.aufirst=A&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - When Should In Vivo Transporter- Mediated Drug-Drug Interaction Studies be Conducted? A Regulatory Perspective T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820695; 6340366 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Zhang, Lei Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Drug interaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=When+Should+In+Vivo+Transporter-+Mediated+Drug-Drug+Interaction+Studies+be+Conducted%3F+A+Regulatory+Perspective&rft.au=Zhang%2C+Lei&rft.aulast=Zhang&rft.aufirst=Lei&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Physiologically-Based Pharmacokinetic Modeling(PBPK) of Pitavastatin and Atorvastatin to Predict Drug-Drug Interactions (DDIS) T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820673; 6340315 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Duan, P AU - Zhao, P AU - Zhang, L Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Drug interaction KW - Atorvastatin KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Physiologically-Based+Pharmacokinetic+Modeling%28PBPK%29+of+Pitavastatin+and+Atorvastatin+to+Predict+Drug-Drug+Interactions+%28DDIS%29&rft.au=Duan%2C+P%3BZhao%2C+P%3BZhang%2C+L&rft.aulast=Duan&rft.aufirst=P&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Little Data, Big Decisions in Regulatory Review T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820609; 6340324 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Krudys, Kevin Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Data processing KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Little+Data%2C+Big+Decisions+in+Regulatory+Review&rft.au=Krudys%2C+Kevin&rft.aulast=Krudys&rft.aufirst=Kevin&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Low-frequency KRAS mutations are prevalent in lung adenocarcinomas AN - 1842508030; PQ0001435717 AB - Aim: This study quantified low-frequency KRAS mutations in normal lung and lung adenocarcinomas, to understand their potential significance in the development of acquired resistance to EGFR-targeted therapies. Materials & methods: Allele-specific Competitive Blocker-PCR was used to quantify KRAS codon 12 GAT (G12D) and GTT (G12V) mutation in 19 normal lung and 21 lung adenocarcinoma samples. Results: Lung adenocarcinomas had KRAS codon 12 GAT and GTT geometric mean mutant fractions of 1.94 10 super(-4) and 1.16 10 super(-3), respectively. For 76.2% of lung adenocarcinomas, the level of KRAS mutation was greater than the upper 95% confidence interval of that in normal lung. Conclusion: KRAS mutant tumor subpopulations, not detectable by DNA sequencing, may drive resistance to EGFR blockade in lung adenocarcinoma patients. JF - Personalized Medicine AU - Myers, Meagan B AU - McKim, Karen L AU - Meng, Fanxue AU - Parsons, Barbara L AD - super(1)Division of Genetic & Molecular Toxicology, US FDA, National Center for Toxicological Research, Jefferson, AR 72079, USA Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 83 EP - 98 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 12 IS - 2 SN - 1741-0541, 1741-0541 KW - Toxicology Abstracts KW - carcinogenesis KW - epidermal growth factor receptor KW - mutation KW - mutation detection KW - non-small-cell lung cancer KW - oncogene KW - oncogene-induced senescence KW - personalized medicine KW - polyclonal tumor origin KW - targeted molecular therapy KW - K-Ras protein KW - DNA sequencing KW - Lung KW - Subpopulations KW - Codons KW - Epidermal growth factor receptors KW - Tumors KW - Adenocarcinoma KW - Mutation KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842508030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personalized+Medicine&rft.atitle=Low-frequency+KRAS+mutations+are+prevalent+in+lung+adenocarcinomas&rft.au=Myers%2C+Meagan+B%3BMcKim%2C+Karen+L%3BMeng%2C+Fanxue%3BParsons%2C+Barbara+L&rft.aulast=Myers&rft.aufirst=Meagan&rft.date=2015-03-01&rft.volume=12&rft.issue=2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Personalized+Medicine&rft.issn=17410541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 64 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - K-Ras protein; DNA sequencing; Lung; Subpopulations; Codons; Epidermal growth factor receptors; Tumors; Adenocarcinoma; Mutation ER - TY - JOUR T1 - Legal Challenges to the International Deployment of Government Public Health and Medical Personnel during Public Health Emergencies: Impact on National and Global Health Security AN - 1718059609; 2011-839612 AB - International deployment of government public health and medical personnel is often necessary to respond to emergencies and enhance global health security. However, there are unique legal challenges for donors and recipient countries. Here, we summarize some of those challenges and existing international fora that may help to identify solutions. Adapted from the source document. JF - The Journal of Law, Medicine & Ethics AU - Davidson, Brent AU - Sherman, Susan AU - Barraza, Leila AU - Marinissen, Maria Julia AD - Acting Chief of the International Assistance & Response Policy Branch, Division of International Health Security, Office of Policy and Planning, Office of the Assistant Secretary for Preparedness and Response, at the U.S. Department of Health and Human Services. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 103 EP - 106 PB - Wiley-Blackwell, UK VL - 43 IS - s1 SN - 1073-1105, 1073-1105 KW - Health conditions and policy - Health and health policy KW - Health policy KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718059609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.atitle=Legal+Challenges+to+the+International+Deployment+of+Government+Public+Health+and+Medical+Personnel+during+Public+Health+Emergencies%3A+Impact+on+National+and+Global+Health+Security&rft.au=Davidson%2C+Brent%3BSherman%2C+Susan%3BBarraza%2C+Leila%3BMarinissen%2C+Maria+Julia&rft.aulast=Davidson&rft.aufirst=Brent&rft.date=2015-03-01&rft.volume=43&rft.issue=s1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.issn=10731105&rft_id=info:doi/10.1111%2Fjlme.12229 LA - English DB - PAIS Index N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Public health; Health policy DO - http://dx.doi.org/10.1111/jlme.12229 ER - TY - JOUR T1 - Community Experiments in Public Health Law and Policy AN - 1718058791; 2011-839611 AB - Community-level legal and policy innovations or 'experiments' can be important levers to improve health. States and localities are empowered through the 10th Amendment of the United States Constitution to use their police powers to protect the health and welfare of the public. This article describes innovative approaches to public health law and policy from Minneapolis and New Orleans, communities who have been honored by the Robert Wood Johnson Foundation (RWJF) for addressing health by focusing not solely on health care access and quality, but the wider environment, including transforming neighborhoods, schools, and businesses and addressing inequities. Specifically, this article discusses examples of how these cities have used public health legal and policy approaches and novel partnerships to promote healthy eating and active living, reduce exposure to secondhand smoke, and prevent violence. Adapted from the source document. JF - The Journal of Law, Medicine & Ethics AU - McGowan, Angela K AU - Musicant, Gretchen G AU - Williams, Sharonda R AU - Niehaus, Virginia R AD - Organized this session as a result of her position as a Senior Program Officer with the Robert Wood Johnson Foundation. She is now a Program Director and Centers for Disease Control and Prevention assignee to the Office of Disease Prevention and Health Promotion at the U.S. Department of Health and Human Services. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 10 EP - 14 PB - Wiley-Blackwell, UK VL - 43 IS - s1 SN - 1073-1105, 1073-1105 KW - Health conditions and policy - Health and health policy KW - Law and ethics - Law and jurisprudence KW - Business and service sector - Business and business enterprises KW - Health conditions and policy - Medicine and health care KW - Economic conditions and policy - Economic policy, planning, and development KW - Business and service sector - Business organization and administration KW - Social conditions and policy - Urban conditions KW - Administration of justice - Police and law enforcement KW - Social conditions and policy - Social conditions and problems KW - Education and education policy - Schools KW - Partnership KW - Business KW - Welfare economics KW - Neighborhoods KW - Environmental health KW - Violence KW - United States Constitution KW - Public health KW - Schools KW - Law KW - Health policy KW - Police KW - Medical service KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718058791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.atitle=Community+Experiments+in+Public+Health+Law+and+Policy&rft.au=McGowan%2C+Angela+K%3BMusicant%2C+Gretchen+G%3BWilliams%2C+Sharonda+R%3BNiehaus%2C+Virginia+R&rft.aulast=McGowan&rft.aufirst=Angela&rft.date=2015-03-01&rft.volume=43&rft.issue=s1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.issn=10731105&rft_id=info:doi/10.1111%2Fjlme.12206 LA - English DB - PAIS Index N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Public health; Health policy; Law; Business; Medical service; Welfare economics; Partnership; Environmental health; Neighborhoods; Police; Violence; United States Constitution; Schools DO - http://dx.doi.org/10.1111/jlme.12206 ER - TY - JOUR T1 - School and Work Status, Drug-Free Workplace Protections, and Prescription Drug Misuse Among Americans Ages 15-25 AN - 1683501437 AB - We assessed the prevalence and characteristics of prescription drug misuse among youth ages 15-25 to examine differences by student and employment status, and associations with workplace antidrug policies and programs. Multivariate logistic regressions analyzed associations in weighted data on the 20,457 young adults in the combined 2004-2008 National Surveys on Drug Use and Health. Protective effects of drug-free workplace policy and EAPs persist after other substance use was controlled for. Comparing the effects of workplace programs on illicit drug use and problem drinking versus prescription misuse suggests that those protective associations do not result from selection bias. Thus, drug-free workplace policies and EAPs appear to help protect younger workers against prescription misuse. If workplace substance use disorder programs focused prevention messages and interventions on prescription drug misuse, their impact on misuse might increase. JF - Journal of Studies on Alcohol and Drugs AU - NOVAK, SCOTT P AU - GALVIN, DEBORAH M AU - SPICER, REBECCA S AU - CLUFF, LAURIE AU - KASAT, SANDEEP AD - RTI International, Research Triangle Park, North Carolina ; Substance Abuse and Mental Health Services Administration, Rockville, Maryland ; Pacific Institute for Research and Evaluation, Calverton, Maryland ; MILLER, TED; Pacific Institute for Research and Evaluation, 11720 Beltsville Drive, Suite 900, Calverton, MD 20705; Centre for Population Health Research, Curtin University, Perth WA 6845 Australia Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 195 EP - 203 CY - Piscataway PB - Alcohol Research Documentation, Inc. VL - 76 IS - 2 SN - 1937-1888 KW - Medical Sciences KW - Substance Abuse KW - Associations KW - Problem drinking KW - Selection bias KW - Substance abuse KW - Work status KW - Workplaces KW - Young adults KW - Young people KW - Social Programs KW - Bias KW - Workers KW - Prevention KW - Social Policy KW - Drug Abuse KW - Employment KW - Health KW - American people KW - Drug abuse KW - Employment status KW - Interventions KW - National surveys KW - Occupational status KW - Organizational policy KW - Preventive programmes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683501437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=School+and+Work+Status%2C+Drug-Free+Workplace+Protections%2C+and+Prescription+Drug+Misuse+Among+Americans+Ages+15-25&rft.au=MILLER%2C+TED%3BNOVAK%2C+SCOTT+P%3BGALVIN%2C+DEBORAH+M%3BSPICER%2C+REBECCA+S%3BCLUFF%2C+LAURIE%3BKASAT%2C+SANDEEP&rft.aulast=MILLER&rft.aufirst=TED&rft.date=2015-03-01&rft.volume=76&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-04-28 N1 - Last updated - 2016-05-13 ER - TY - JOUR T1 - Comparative effectiveness of high-dose versus standard-dose influenza vaccines in US residents aged 65 years and older from 2012 to 2013 using Medicare data: a retrospective cohort analysis AN - 1668267461; PQ0001205015 AB - Background A high-dose trivalent inactivated influenza vaccine was licensed in 2009 by the US Food and Drug Administration (FDA) on the basis of serological criteria. We sought to establish whether high-dose inactivated influenza vaccine was more effective for prevention of influenza-related visits and hospital admissions in US Medicare beneficiaries than was standard-dose inactivated influenza vaccine. Methods In this retrospective cohort study, we identified Medicare beneficiaries aged 65 years and older who received high-dose or standard-dose inactivated influenza vaccines from community pharmacies that offered both vaccines during the 2012-13 influenza season. Outcomes were defined with billing codes on Medicare claims. The primary outcome was probable influenza infection, defined by receipt of a rapid influenza test followed by dispensing of the neuraminidase inhibitor oseltamivir. The secondary outcome was a hospital or emergency department visit, listing a Medicare billing code for influenza. We estimated relative vaccine effectiveness by comparing outcome rates in Medicare beneficiaries during periods of high influenza circulation. Univariate and multivariate Poisson regression models were used for analyses. Findings Between Aug 1, 2012 and Jan 31, 2013, we studied 929730 recipients of high-dose vaccine and 1615545 recipients of standard-dose vaccine. Participants enrolled in each cohort were well balanced with respect to age and presence of underlying medical disorders. The high-dose vaccine (1.30 outcomes per 10000 person-weeks) was 22% (95% CI 15-29) more effective than the standard-dose vaccine (1.01 outcomes per 10000 person-weeks) for prevention of probable influenza infections (rapid influenza test followed by oseltamivir treatment) and 22% (95% CI 16-27%) more effective for prevention of influenza hospital admissions (0.86 outcomes per 10000 person-weeks in the high-dose cohort vs 1.10 outcomes per 10000 person-weeks in the standard-dose cohort). Interpretation Our retrospective cohort study in US Medicare beneficiaries shows that, in people 65 years of age and older, high-dose inactivated influenza vaccine was significantly more effective than standard-dose vaccine in prevention of influenza-related medical encounters. Additionally, the large population in our study enabled us to show, for the first time, a significant reduction in influenza-related hospital admissions in high-dose compared to standard-dose vaccine recipients, an outcome not shown in randomised studies. These results provide important new information to be considered by policy makers recommending influenza vaccinations for elderly people. Funding FDA and the office of the Assistant Secretary of Planning and Evaluation. JF - Lancet Infectious Diseases AU - Izurieta, Hector S AU - Thadani, Nicole AU - Shay, David K AU - Lu, Yun AU - Maurer, Aaron AU - Foppa, Ivo M AU - Franks, Riley AU - Pratt, Douglas AU - Forshee, Richard A AU - MaCurdy, Thomas AU - Worrall, Chris AU - Howery, Andrew E AU - Kelman, Jeffrey AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 293 EP - 300 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 15 IS - 3 SN - 1473-3099, 1473-3099 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Age KW - Elderly KW - Infection KW - Models KW - Influenza KW - Infectious diseases KW - Regression analysis KW - Geriatrics KW - Exo- alpha -sialidase KW - Drugs KW - Data processing KW - Population studies KW - Vaccination KW - Oseltamivir KW - Prevention KW - FDA KW - Vaccines KW - Emergency medical services KW - Hospitals KW - H 4000:Food and Drugs KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668267461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+Infectious+Diseases&rft.atitle=Comparative+effectiveness+of+high-dose+versus+standard-dose+influenza+vaccines+in+US+residents+aged+65+years+and+older+from+2012+to+2013+using+Medicare+data%3A+a+retrospective+cohort+analysis&rft.au=Izurieta%2C+Hector+S%3BThadani%2C+Nicole%3BShay%2C+David+K%3BLu%2C+Yun%3BMaurer%2C+Aaron%3BFoppa%2C+Ivo+M%3BFranks%2C+Riley%3BPratt%2C+Douglas%3BForshee%2C+Richard+A%3BMaCurdy%2C+Thomas%3BWorrall%2C+Chris%3BHowery%2C+Andrew+E%3BKelman%2C+Jeffrey&rft.aulast=Izurieta&rft.aufirst=Hector&rft.date=2015-03-01&rft.volume=15&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Lancet+Infectious+Diseases&rft.issn=14733099&rft_id=info:doi/10.1016%2FS1473-3099%2814%2971087-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 28 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Population studies; Infection; Vaccination; Oseltamivir; Models; Influenza; Geriatrics; Regression analysis; Vaccines; Exo- alpha -sialidase; Hospitals; Prevention; Infectious diseases; Elderly; FDA; Drugs; Emergency medical services DO - http://dx.doi.org/10.1016/S1473-3099(14)71087-4 ER - TY - JOUR T1 - Randomized single-blinded non-inferiority trial of 7 mg/kg pentamidine isethionate versus 4 mg/kg pentamidine isethionate for cutaneous leishmaniaisis in Suriname. AN - 1666294831; 25793773 AB - Standard treatment of cutaneous leishmaniasis (CL) in Suriname entails three injections of pentamidine isethionate (PI) 4 mg/kg per injection in 7 days (7 day regimen). Compliance to treatment is low and may contribute to increasing therapy failure. A 3 day regimen, including 2 injections of 7 mg/kg in 3 days may increase compliance. In a randomized, single-blinded non-inferiority trial conducted in Suriname, 84 CL patients received the 7 day regimen and 79 CL patients received the 3 day regimen. Primary objective was the proportion of patients clinically cured at 6 weeks follow-up. Secondary objectives were clinical cure at 12 weeks follow-up; parasitological cure at 6 and 12 weeks; adverse and drug related toxicity events recorded one week after the end of treatment and health related quality of life. The non-inferiority margin was set at 15%, 1 sided test, α = 0.1. At 6 weeks follow-up 31 (39%) patients in the 3 day regimen and 41 (49%) patients in the 7 day regimen were clinically cured. Intention to treat (ITT) analyses showed that the difference in proportion clinically cured was -9.6% (90% Confidence Interval (CI): -22.3% to 3.2%). Per protocol (PP) analysis showed that the difference in proportion clinically cured was 0.2% (90% CI: -14.6% to 15.2%). ITT analysis showed that the difference in proportion parasitological cured at 6 weeks was -15.2% (90% CI:-28.0% to -2.5%). PP analyses showed similar results. Non-inferiority could not be concluded for all adverse and toxicological events. We cannot conclude that the 3 day regimen is non-inferior to the 7 day regimen regarding proportion clinically and parasitological cured. Therefore there is no evidence to change the current standard practice of the 7 day regimen for the treatment of CL in Suriname. JF - PLoS neglected tropical diseases AU - Hu, Ricardo V P F AU - Straetemans, Masja AU - Kent, Alida D AU - Sabajo, Leslie O A AU - de Vries, Henry J C AU - Fat, Rudy F M Lai A AD - Dermatology Service, Ministry of Health, Paramaribo, Suriname. ; Department of Biomedical Research, Royal Tropical Institute, KIT, Amsterdam, The Netherlands. ; Department of Parasitology, Anton de Kom University of Suriname, Paramaribo, Suriname. ; Centre for Infections and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; STI Outpatient Clinic, Cluster Infectious Diseases, Public Health Service Amsterdam, Amsterdam, The Netherlands. ; Department of Dermatology, Academic Hospital, Paramaribo, Suriname. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 1 VL - 9 IS - 3 KW - Pentamidine KW - 673LC5J4LQ KW - Index Medicus KW - Young Adult KW - Patient Compliance KW - Dose-Response Relationship, Drug KW - Humans KW - Intention to Treat Analysis KW - Adult KW - Treatment Outcome KW - Quality of Life KW - Aged KW - Suriname KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Leishmaniasis, Cutaneous -- drug therapy KW - Pentamidine -- administration & dosage KW - Pentamidine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1666294831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+neglected+tropical+diseases&rft.atitle=Randomized+single-blinded+non-inferiority+trial+of+7+mg%2Fkg+pentamidine+isethionate+versus+4+mg%2Fkg+pentamidine+isethionate+for+cutaneous+leishmaniaisis+in+Suriname.&rft.au=Hu%2C+Ricardo+V+P+F%3BStraetemans%2C+Masja%3BKent%2C+Alida+D%3BSabajo%2C+Leslie+O+A%3Bde+Vries%2C+Henry+J+C%3BFat%2C+Rudy+F+M+Lai+A&rft.aulast=Hu&rft.aufirst=Ricardo+V+P&rft.date=2015-03-01&rft.volume=9&rft.issue=3&rft.spage=e0003592&rft.isbn=&rft.btitle=&rft.title=PLoS+neglected+tropical+diseases&rft.issn=1935-2735&rft_id=info:doi/10.1371%2Fjournal.pntd.0003592 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-03-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Dermatol. 2002 Nov;41(11):796-800 [12453009] Ann Trop Med Parasitol. 2006 Jun;100(4):307-14 [16762111] J Clin Microbiol. 1990 Mar;28(3):495-503 [1691208] Health Policy. 1990 Dec;16(3):199-208 [10109801] Clin Microbiol Rev. 2006 Jan;19(1):111-26 [16418526] J Invest Dermatol. 1996 Nov;107(5):707-13 [8875954] Trans R Soc Trop Med Hyg. 2013 May;107(5):335-6 [23474473] JAMA. 2006 Mar 8;295(10):1147-51 [16522835] J Hepatol. 2007 May;46(5):947-54 [17412447] Emerg Infect Dis. 2008 May;14(5):857-9 [18439386] PLoS Negl Trop Dis. 2008;2(10):e259 [18958168] Int J Dermatol. 2009 Jan;48(1):52-8 [19126051] Am J Trop Med Hyg. 2010 Apr;82(4):588-90 [20348504] Am J Trop Med Hyg. 2011 Feb;84(2):255-60 [21292895] J Invest Dermatol. 2011 Sep;131(9):1945-7 [21593773] J Infect Dis. 2012 Feb 15;205(4):684-92 [22238470] Am J Trop Med Hyg. 2012 May;86(5):825-7 [22556081] Soc Sci Med. 2012 Sep;75(6):1097-105 [22704264] Int J Dermatol. 2002 Jan;41(1):32-7 [11895511] Diagn Microbiol Infect Dis. 2003 Jun;46(2):115-24 [12812715] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pntd.0003592 ER - TY - JOUR T1 - Quantification of Optical and Physical Properties of Combustion-Generated Carbonaceous Aerosols (< PM sub(2.5)) Using Analytical and Microscopic Techniques AN - 1664217149; PQ0001240216 AB - A series of experiments were conducted to quantify and characterize the optical and physical properties of combustion-generated aerosols during both flaming and smoldering combustion of three materials common to underground mines-Pittsburgh Seam coal, Styrene Butadiene Rubber (a common mine conveyor belt material), and Douglas-fir wood-using a combination of analytical and gravimetric measurements. Laser photometers were utilized in the experiments for continuous measurement of aerosol mass concentrations and for comparison to measurements made using gravimetric filter samples. The aerosols of interest lie in the size range of tens to a few hundred nanometers, out of range of the standard photometer calibration. To correct for these uncertainties, the photometer mass concentrations were compared to gravimetric samples to determine if consistent correlations existed. The response of a calibrated and modified combination ionization/photoelectric smoke detector was also used. In addition, the responses of this sensor and a similar, prototype ionization/photoelectric sensor, along with discrete angular scattering, total scattering, and total extinction measurements, were used to define in real time the size, morphology, and radiative transfer properties of these differing aerosols that are generally in the form of fractal aggregates. SEM/TEM images were also obtained in order to compare qualitatively the real-time, continuous experimental measurements with the visual microscopic measurements. These data clearly show that significant differences exist between aerosols from flaming and from smoldering combustion and that these differences produce very different scattering and absorption signatures. The data also indicate that ionization/photoelectric sensors can be utilized to measure continuously and in real time aerosol properties over a broad spectrum of applications related to adverse environmental and health effects. JF - Fire Technology AU - Perera, Inoka Eranda AU - Litton, Charles D AD - Pittsburgh Research Laboratory, Fires and Explosions Branch, Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health, Centers for Disease Control & Prevention, U. S. Department of Health & Human Services, 626 Cochrans Mill Road, PO Box 18070, Pittsburgh, PA, 15236, USA, eperera@cdc.gov Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 247 EP - 269 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 51 IS - 2 SN - 0015-2684, 0015-2684 KW - Health & Safety Science Abstracts KW - Styrene KW - Fires KW - Aerosols KW - Extinction KW - Sensors KW - Prototypes KW - Coal KW - Combustion KW - Smoke KW - Optical analysis KW - Morphology KW - Photometers KW - Lasers KW - Radiative transfer KW - H 7000:Fire Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664217149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fire+Technology&rft.atitle=Quantification+of+Optical+and+Physical+Properties+of+Combustion-Generated+Carbonaceous+Aerosols+%28%26lt%3B+PM+sub%282.5%29%29+Using+Analytical+and+Microscopic+Techniques&rft.au=Perera%2C+Inoka+Eranda%3BLitton%2C+Charles+D&rft.aulast=Perera&rft.aufirst=Inoka&rft.date=2015-03-01&rft.volume=51&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Fire+Technology&rft.issn=00152684&rft_id=info:doi/10.1007%2Fs10694-013-0376-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 22 N1 - Last updated - 2015-04-29 N1 - SubjectsTermNotLitGenreText - Styrene; Fires; Aerosols; Sensors; Extinction; Prototypes; Coal; Combustion; Optical analysis; Smoke; Morphology; Photometers; Lasers; Radiative transfer DO - http://dx.doi.org/10.1007/s10694-013-0376-z ER - TY - JOUR T1 - Impact of Natural IgM Concentration on Gene Therapy with Adenovirus Type 5 Vectors AN - 1664202634; PQ0001232820 AB - Natural IgM inhibits gene transfer by adenovirus type 5 (Ad5) vectors. We show that polyreactive natural IgM antibodies bind to Ad5 and that inhibition of liver transduction by IgM depends on Kupffer cells. By manipulating IgM concentration in vivo, we demonstrate that IgM inhibits liver transduction in a concentration-dependent manner. We further show that differences in natural IgM between BALB/c and C57BL/6 mice contribute to lower efficiency of Ad5 gene transfer in BALB/c mice. JF - Journal of Virology AU - Qiu, Qi AU - Xu, Zhili AU - Tian, Jie AU - Moitra, Rituparna AU - Gunti, Sreenivasulu AU - Notkins, Abner L AU - Byrnes, Andrew P AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA, Andrew.Byrnes@FDA.HHS.gov. PY - 2015 SP - 3412 EP - 3416 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 89 IS - 6 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Genetics Abstracts; Virology & AIDS Abstracts KW - Expression vectors KW - Kupffer cells KW - Gene therapy KW - Adenovirus KW - Liver KW - Immunoglobulin M KW - G 07720:Immunogenetics KW - W 30905:Medical Applications KW - V 22410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664202634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Impact+of+Natural+IgM+Concentration+on+Gene+Therapy+with+Adenovirus+Type+5+Vectors&rft.au=Qiu%2C+Qi%3BXu%2C+Zhili%3BTian%2C+Jie%3BMoitra%2C+Rituparna%3BGunti%2C+Sreenivasulu%3BNotkins%2C+Abner+L%3BByrnes%2C+Andrew+P&rft.aulast=Qiu&rft.aufirst=Qi&rft.date=2015-03-01&rft.volume=89&rft.issue=6&rft.spage=3412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.03217-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 28 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Expression vectors; Kupffer cells; Gene therapy; Liver; Immunoglobulin M; Adenovirus DO - http://dx.doi.org/10.1128/JVI.03217-14 ER - TY - JOUR T1 - Antibody-Mediated Complement C3b/iC3b Binding to Group B Streptococcus in Paired Mother and Baby Serum Samples in a Refugee Population on the Thailand-Myanmar Border AN - 1664200068; PQ0001232512 AB - Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal sepsis and meningitis. In this study, we determined antibody-mediated deposition of complement C3b/iC3b onto the bacterial cell surface of GBS serotypes Ia, Ib, II, III, and V. This was determined for 520 mother and umbilical cord serum sample pairs obtained at the time of birth from a population on the Thailand-Myanmar border. Antibody-mediated deposition of complement C3b/iC3b was detected to at least one serotype in 91% of mothers, despite a known carriage rate in this population of only 12%. Antibody-mediated C3b/iC3b deposition corresponded to known carriage rates, with the highest levels of complement deposition observed onto the most prevalent serotype (serotype II) followed by serotypes Ia, III, V, and Ib. Finally, neonates born to mothers carrying serotype II GBS at the time of birth showed higher antibody-mediated C3b/iC3b deposition against serotype II GBS than neonates born to mothers with no serotype II carriage. Assessment of antibody-mediated C3b/iC3b deposition against GBS may provide insights into the seroepidemiology of anti-GBS antibodies in mothers and infants in different populations. JF - Clinical and Vaccine Immunology AU - Herbert, Jenny AU - Thomas, Stephen AU - Brookes, Charlotte AU - Turner, Claudia AU - Turner, Paul AU - Nosten, Francois AU - Doare, Kirsty Le AU - Hudson, Michael AU - Heath, Paul T AU - Gorringe, Andrew AD - Public Health England, Porton Down, Salisbury, United Kingdom, stephen.taylor@phe.gov.uk. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 319 EP - 326 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 22 IS - 3 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell surface KW - Serotypes KW - Umbilical cord KW - Meningitis KW - Birth KW - Antibodies KW - Sepsis KW - Complement component C3b KW - Streptococcus agalactiae KW - Neonates KW - Seroepidemiology KW - Infants KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664200068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Antibody-Mediated+Complement+C3b%2FiC3b+Binding+to+Group+B+Streptococcus+in+Paired+Mother+and+Baby+Serum+Samples+in+a+Refugee+Population+on+the+Thailand-Myanmar+Border&rft.au=Herbert%2C+Jenny%3BThomas%2C+Stephen%3BBrookes%2C+Charlotte%3BTurner%2C+Claudia%3BTurner%2C+Paul%3BNosten%2C+Francois%3BDoare%2C+Kirsty+Le%3BHudson%2C+Michael%3BHeath%2C+Paul+T%3BGorringe%2C+Andrew&rft.aulast=Herbert&rft.aufirst=Jenny&rft.date=2015-03-01&rft.volume=22&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00803-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 46 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Birth; Cell surface; Sepsis; Antibodies; Serotypes; Complement component C3b; Seroepidemiology; Neonates; Umbilical cord; Meningitis; Infants; Streptococcus agalactiae DO - http://dx.doi.org/10.1128/CVI.00803-14 ER - TY - JOUR T1 - A scalable method to concentrate lentiviral vectors pseudotyped with measles virus glycoproteins AN - 1664196789; PQ0001238759 AB - Lentiviral (LV) vectors have emerged as powerful tools for basic research and clinical applications because of their ability to stably transduce both dividing and nondividing cells. A wide range of viral envelope (Env) glycoproteins have the ability to associate with the membrane of LV vectors, a process that is referred to as pseudotyping. Pseudotyped vectors have the capacity to transduce specific cell types for specific applications. For example, LV vectors pseudotyped with the measles virus (MV)-derived hemagglutinin (H) and fusion (F) proteins have the ability to transduce quiescent lymphocytes. In addition, the MV H glycoprotein can be engineered allowing cell-specific targeting of LV vectors. One problem with MV glycoprotein-pseudotyped LV vectors is low titer during vector production. This results in the need to manufacture large volumes of the vectors and to concentrate them to appropriate titers. The commonly used centrifugation-based concentration techniques for LV vectors are not practical for large-scale vector manufacturing. Thus, there is a need for improved methods to concentrate LV vectors. In this study, we adapted an anion-exchange membrane chromatography method that we previously used in the context of LV vectors pseudotyped with the vesicular stomatitis virus glycoprotein to concentate MV glycoprotein-pseudotyped LV vectors. Up to 60% of the input vectors with an up to 5300-fold reduction in volume was achieved using this anion-exchange chromatography method in conjunction with a desalting/concentration step involving centrifugal filter units. This technique provides a rapid and scalable approach for concentrating MV-pseudotyped LV vectors that does not require an elaborate setup. JF - Gene Therapy AU - Marino, M P AU - Panigaj, M AU - Ou, W AU - Manirarora, J AU - Wei, C-H AU - Reiser, J AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, USA Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 64 EP - 69 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 22 IS - 3 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Anion-exchange chromatography KW - Filters KW - Envelopes KW - Gene therapy KW - Hemagglutinins KW - F protein KW - Therapeutic applications KW - Glycoproteins KW - Lymphocytes KW - Measles virus KW - Vesicular stomatitis virus KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664196789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=A+scalable+method+to+concentrate+lentiviral+vectors+pseudotyped+with+measles+virus+glycoproteins&rft.au=Marino%2C+M+P%3BPanigaj%2C+M%3BOu%2C+W%3BManirarora%2C+J%3BWei%2C+C-H%3BReiser%2C+J&rft.aulast=Marino&rft.aufirst=M&rft.date=2015-03-01&rft.volume=22&rft.issue=3&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2014.125 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Filters; Anion-exchange chromatography; Envelopes; Gene therapy; Hemagglutinins; F protein; Therapeutic applications; Lymphocytes; Glycoproteins; Measles virus; Vesicular stomatitis virus DO - http://dx.doi.org/10.1038/gt.2014.125 ER - TY - JOUR T1 - Intravenous and gastric cerium dioxide nanoparticle exposure disrupts microvascular smooth muscle signaling. AN - 1661333890; 25481005 AB - Cerium dioxide nanoparticles (CeO2 NP) hold great therapeutic potential, but the in vivo effects of non-pulmonary exposure routes are unclear. The first aim was to determine whether microvascular function is impaired after intravenous and gastric CeO2 NP exposure. The second aim was to investigate the mechanism(s) of action underlying microvascular dysfunction following CeO2 NP exposure. Rats were exposed to CeO2 NP (primary diameter: 4 ± 1 nm, surface area: 81.36 m(2)/g) by intratracheal instillation, intravenous injection, or gastric gavage. Mesenteric arterioles were harvested 24 h post-exposure and vascular function was assessed using an isolated arteriole preparation. Endothelium-dependent and independent function and vascular smooth muscle (VSM) signaling (soluble guanylyl cyclase [sGC] and cyclic guanosine monophosphate [cGMP]) were assessed. Reactive oxygen species (ROS) generation and nitric oxide (NO) production were analyzed. Compared with controls, endothelium-dependent and independent dilation were impaired following intravenous injection (by 61% and 45%) and gastric gavage (by 63% and 49%). However, intravenous injection resulted in greater microvascular impairment (16% and 35%) compared with gastric gavage at an identical dose (100 µg). Furthermore, sGC activation and cGMP responsiveness were impaired following pulmonary, intravenous, and gastric CeO2 NP treatment. Finally, nanoparticle exposure resulted in route-dependent, increased ROS generation and decreased NO production. These results indicate that CeO2 NP exposure route differentially impairs microvascular function, which may be mechanistically linked to decreased NO production and subsequent VSM signaling. Fully understanding the mechanisms behind CeO2 NP in vivo effects is a critical step in the continued therapeutic development of this nanoparticle. © The Author 2014. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Minarchick, Valerie C AU - Stapleton, Phoebe A AU - Fix, Natalie R AU - Leonard, Stephen S AU - Sabolsky, Edward M AU - Nurkiewicz, Timothy R AD - *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506 *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506. ; *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506. ; *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506 *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506 *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506 tnurkiewicz@hsc.wvu.edu. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 77 EP - 89 VL - 144 IS - 1 KW - Reactive Oxygen Species KW - 0 KW - Receptors, Cytoplasmic and Nuclear KW - Cerium KW - 30K4522N6T KW - Nitric Oxide KW - 31C4KY9ESH KW - ceric oxide KW - 619G5K328Y KW - Guanylate Cyclase KW - EC 4.6.1.2 KW - Soluble Guanylyl Cyclase KW - Cyclic GMP KW - H2D2X058MU KW - Index Medicus KW - cerium dioxide nanoparticles; microvascular function; nitric oxide; mesentery KW - Administration, Oral KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Particle Size KW - Intubation, Gastrointestinal KW - Nitric Oxide -- metabolism KW - Epithelial Cells -- metabolism KW - Guanylate Cyclase -- metabolism KW - Rats, Sprague-Dawley KW - Cyclic GMP -- metabolism KW - Epithelial Cells -- drug effects KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Administration, Inhalation KW - Male KW - Myocytes, Smooth Muscle -- drug effects KW - Arterioles -- metabolism KW - Signal Transduction -- drug effects KW - Muscle, Smooth, Vascular -- drug effects KW - Mesentery -- blood supply KW - Vasodilation -- drug effects KW - Myocytes, Smooth Muscle -- metabolism KW - Muscle, Smooth, Vascular -- metabolism KW - Nanoparticles KW - Cerium -- toxicity KW - Arterioles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1661333890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Intravenous+and+gastric+cerium+dioxide+nanoparticle+exposure+disrupts+microvascular+smooth+muscle+signaling.&rft.au=Minarchick%2C+Valerie+C%3BStapleton%2C+Phoebe+A%3BFix%2C+Natalie+R%3BLeonard%2C+Stephen+S%3BSabolsky%2C+Edward+M%3BNurkiewicz%2C+Timothy+R&rft.aulast=Minarchick&rft.aufirst=Valerie&rft.date=2015-03-01&rft.volume=144&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu256 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-30 N1 - Date created - 2015-03-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cardiovasc Res. 2002 Aug 1;55(2):250-60 [12123764] Ann Med. 2003;35(1):21-7 [12693609] Circ Res. 2003 Aug 22;93(4):280-91 [12933699] Mol Pharmacol. 2004 May;65(5):1111-9 [15102939] Adv Drug Deliv Rev. 2004 Sep 22;56(11):1649-59 [15350294] Front Biosci. 2004 Sep 1;9:3434-46 [15353368] Free Radic Biol Med. 1987;3(4):259-303 [2826304] Free Radic Res Commun. 1987;3(6):357-64 [2854531] Am J Physiol. 1992 Nov;263(5 Pt 2):H1486-91 [1443200] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6529-34 [9177252] Am J Physiol Gastrointest Liver Physiol. 2006 Mar;290(3):G535-42 [16269521] Biomaterials. 2008 Jun;29(18):2705-9 [18395249] Circ Res. 2008 May 23;102(10):1148-50 [18497313] Toxicol Sci. 2009 Feb;107(2):342-51 [19023088] Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H359-69 [19060128] Toxicol Sci. 2009 Jul;110(1):191-203 [19270016] Inhal Toxicol. 2009 Jul;21 Suppl 1:123-30 [19558244] Cardiovasc Toxicol. 2010 Mar;10(1):27-36 [20033351] Mol Biosyst. 2010 Oct;6(10):1813-20 [20697616] Environ Health Perspect. 2011 Jan;119(1):98-103 [20870565] J Exp Ther Oncol. 2011;9(1):47-51 [21275265] Crit Rev Toxicol. 2011 Mar;41(3):213-29 [21244219] Toxicol Lett. 2011 Aug 28;205(2):105-15 [21624445] Nanotoxicology. 2011 Sep;5(3):312-25 [20925443] Nanotoxicology. 2011 Dec;5(4):531-45 [21043986] Int J Nanomedicine. 2011;6:2327-35 [22072870] Toxicol Sci. 2012 May;127(1):256-68 [22367688] Toxicol Sci. 2012 Jun;127(2):463-73 [22430073] ACS Nano. 2012 May 22;6(5):3767-75 [22524692] Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11039-43 [22968916] Environ Toxicol. 2013 Feb;28(2):107-18 [21618676] Cardiovasc Toxicol. 2013 Dec;13(4):323-37 [23645470] Part Fibre Toxicol. 2014;11:13 [24666995] Am J Physiol Heart Circ Physiol. 2000 Aug;279(2):H459-65 [10924042] J Pathol. 2000 Feb;190(3):244-54 [10685059] Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Jul-Aug;6(4):338-48 [24777845] Semin Thromb Hemost. 2000;26(5):539-45 [11129410] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu256 ER - TY - JOUR T1 - FDA approval: siltuximab for the treatment of patients with multicentric Castleman disease. AN - 1660655146; 25601959 AB - On April 22, 2014, the FDA granted full approval to siltuximab (SYLVANT for injection; Janssen Biotech, Inc.), a chimeric human-mouse monoclonal antibody to IL6, for the treatment of patients with multicentric Castleman disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative. The approval was primarily based on the results of a randomized, double-blind trial in which 79 symptomatic patients with MCD were allocated (2:1) to siltuximab plus best supportive care (BSC) or to placebo plus BSC. The primary efficacy endpoint was the proportion of patients in each arm achieving a durable tumor and symptomatic response that persisted for a minimum of 18 weeks without treatment failure. Tumor response was based on independent review of CT scans using the revised Response Criteria for Malignant Lymphoma, and symptomatic response was defined as complete resolution or stabilization of 34 MCD-related signs and symptoms as reported by the investigator. Thirty-four percent of patients in the siltuximab arm and no patients in the placebo arm met the primary endpoint (P = 0.0012). The most common adverse reactions (>10% compared with placebo) during treatment with siltuximab were pruritus, increased weight, rash, hyperuricemia, and upper respiratory tract infection. ©2015 American Association for Cancer Research. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Deisseroth, Albert AU - Ko, Chia-Wen AU - Nie, Lei AU - Zirkelbach, Jeanne F AU - Zhao, Liang AU - Bullock, Julie AU - Mehrotra, Nitin AU - Del Valle, Pedro AU - Saber, Haleh AU - Sheth, Christopher AU - Gehrke, Brenda AU - Justice, Robert AU - Farrell, Ann AU - Pazdur, Richard AD - Office of Hematology and Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. Albert.Deisseroth@fda.hhs.gov. ; Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Hematology and Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. Y1 - 2015/03/01/ PY - 2015 DA - 2015 Mar 01 SP - 950 EP - 954 VL - 21 IS - 5 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - Antineoplastic Agents KW - siltuximab KW - Index Medicus KW - United States KW - Animals KW - Humans KW - Adult KW - Treatment Outcome KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Drug Evaluation, Preclinical KW - United States Food and Drug Administration KW - Giant Lymph Node Hyperplasia -- diagnosis KW - Giant Lymph Node Hyperplasia -- drug therapy KW - Drug Approval KW - Antibodies, Monoclonal -- pharmacology KW - Antibodies, Monoclonal -- chemistry KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660655146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=FDA+approval%3A+siltuximab+for+the+treatment+of+patients+with+multicentric+Castleman+disease.&rft.au=Deisseroth%2C+Albert%3BKo%2C+Chia-Wen%3BNie%2C+Lei%3BZirkelbach%2C+Jeanne+F%3BZhao%2C+Liang%3BBullock%2C+Julie%3BMehrotra%2C+Nitin%3BDel+Valle%2C+Pedro%3BSaber%2C+Haleh%3BSheth%2C+Christopher%3BGehrke%2C+Brenda%3BJustice%2C+Robert%3BFarrell%2C+Ann%3BPazdur%2C+Richard&rft.aulast=Deisseroth&rft.aufirst=Albert&rft.date=2015-03-01&rft.volume=21&rft.issue=5&rft.spage=950&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-1678 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-18 N1 - Date created - 2015-03-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: Clin Cancer Res. 2015 Oct 15;21(20):4740 [26473194] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-1678 ER - TY - JOUR T1 - Occupational burns treated in emergency departments AN - 1660417328; PQ0001110016 AB - Background Despite reported declines, occupational burn injuries remain a workplace safety concern. More severe burns may result in costly medical treatment and long-term physical and psychological consequences. Methods We used the National Electronic Injury Surveillance System-Occupational Supplement to produce national estimates of burns treated in emergency departments (EDs). We analyzed data trends from 1999 to 2008 and provided detailed descriptions of 2008 data. Results From 1999 to 2008 there were 1,132,000 (95% CI: plus or minus 192,300) nonfatal occupational burns treated in EDs. Burn numbers and rates declined approximately 40% over the 10 years. In 2008, men and younger workers 15-24 years old had the highest rates. Scalds and thermal burns accounted for more than 60% of burns. Accommodation and food service, manufacturing, and construction industries had the largest number of burns. Conclusions Despite declining burn rates, emphasis is needed on reducing burn hazards to young food service workers and using job specific hazard analyses to prevent burns. Am. J. Ind. Med. 58:290-298, 2015. copyright 2015 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Reichard, Audrey A AU - Konda, Srinivas AU - Jackson, Larry L AD - Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 290 EP - 298 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 3 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Burns KW - Injuries KW - Psychology KW - Occupational safety KW - Medical treatment KW - Construction industry KW - Emergency medical services KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660417328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Occupational+burns+treated+in+emergency+departments&rft.au=Reichard%2C+Audrey+A%3BKonda%2C+Srinivas%3BJackson%2C+Larry+L&rft.aulast=Reichard&rft.aufirst=Audrey&rft.date=2015-03-01&rft.volume=58&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Burns; Injuries; Psychology; Occupational safety; Medical treatment; Construction industry; Emergency medical services DO - http://dx.doi.org/10.1002/ajim.22407 ER - TY - JOUR T1 - Breast cancer incidence in a cohort of U.S. flight attendants AN - 1660415118; PQ0001110017 AB - Background Flight attendants may have elevated breast cancer incidence (BCI). We evaluated BCI's association with cosmic radiation dose and circadian rhythm disruption among 6,093 female former U.S. flight attendants. Methods We collected questionnaire data on BCI and risk factors for breast cancer from 2002-2005. We conducted analyses to evaluate (i) BCI in the cohort compared to the U.S. population; and (ii) exposure-response relations. We applied an indirect adjustment to estimate whether parity and age at first birth (AFB) differences between the cohort and U.S. population could explain BCI that differed from expectation. Results BCI was elevated but may be explained by lower parity and older AFB in the cohort than among U.S. women. BCI was not associated with exposure metrics in the cohort overall. Significant positive associations with both were observed only among women with parity of three or more. Conclusions Future cohort analyses may be informative on the role of these occupational exposures and non-occupational risk factors. Am. J. Ind. Med. 58:252-266, 2015. copyright 2015 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Schubauer-Berigan, Mary K AU - Anderson, Jeri L AU - Hein, Misty J AU - Little, Mark P AU - Sigurdson, Alice J AU - Pinkerton, Lynne E AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Industrywide Studies Branch, Cincinnati, Ohio. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 252 EP - 266 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 3 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Parity KW - Health risks KW - Age KW - Risk factors KW - Dose-response effects KW - Cosmic radiation KW - Circadian rhythms KW - Breast cancer KW - Crew safety KW - Occupational exposure KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660415118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Breast+cancer+incidence+in+a+cohort+of+U.S.+flight+attendants&rft.au=Schubauer-Berigan%2C+Mary+K%3BAnderson%2C+Jeri+L%3BHein%2C+Misty+J%3BLittle%2C+Mark+P%3BSigurdson%2C+Alice+J%3BPinkerton%2C+Lynne+E&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2015-03-01&rft.volume=58&rft.issue=3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22419 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Parity; Health risks; Age; Dose-response effects; Risk factors; Cosmic radiation; Circadian rhythms; Breast cancer; Crew safety; Occupational exposure DO - http://dx.doi.org/10.1002/ajim.22419 ER - TY - JOUR T1 - Developmental toxicity assay using high content screening of zebrafish embryos AN - 1660398592; PQ0001007588 AB - Typically, time-consuming standard toxicological assays using the zebrafish (Danio rerio) embryo model evaluate mortality and teratogenicity after exposure during the first 2days post-fertilization. Here we describe an automated image-based high content screening (HCS) assay to identify the teratogenic/embryotoxic potential of compounds in zebrafish embryos in vivo. Automated image acquisition was performed using a high content microscope system. Further automated analysis of embryo length, as a statistically quantifiable endpoint of toxicity, was performed on images post-acquisition. The biological effects of ethanol, nicotine, ketamine, caffeine, dimethyl sulfoxide and temperature on zebrafish embryos were assessed. This automated developmental toxicity assay, based on a growth-retardation endpoint should be suitable for evaluating the effects of potential teratogens and developmental toxicants in a high throughput manner. This approach can significantly expedite the screening of potential teratogens and developmental toxicants, thereby improving the current risk assessment process by decreasing analysis time and required resources. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. High content assay quantifies developmental toxicity in zebrafish embryos. JF - Journal of Applied Toxicology AU - Lantz-McPeak, Susan AU - Guo, Xiaoqing AU - Cuevas, Elvis AU - Dumas, Melanie AU - Newport, Glenn D AU - Ali, Syed F AU - Paule, Merle G AU - Kanungo, Jyotshna AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 261 EP - 272 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 35 IS - 3 SN - 0260-437X, 0260-437X KW - ASFA 1: Biological Sciences & Living Resources; Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Risk assessment KW - Toxicants KW - Freshwater fish KW - Models KW - Nicotine KW - Ketamine KW - Embryos KW - Caffeine KW - Ethanol KW - Abiotic factors KW - Temperature effects KW - Screening KW - Mortality KW - Microscopes KW - Temperature KW - Embryonic development KW - Assays KW - Toxicity KW - Danio rerio KW - USA KW - Biological effects KW - Dimethyl sulfoxide KW - Teratogenicity KW - Teratogens KW - Mortality causes KW - X 24380:Social Poisons & Drug Abuse KW - H 14000:Toxicology KW - Q1 08604:Stock assessment and management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660398592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Developmental+toxicity+assay+using+high+content+screening+of+zebrafish+embryos&rft.au=Lantz-McPeak%2C+Susan%3BGuo%2C+Xiaoqing%3BCuevas%2C+Elvis%3BDumas%2C+Melanie%3BNewport%2C+Glenn+D%3BAli%2C+Syed+F%3BPaule%2C+Merle+G%3BKanungo%2C+Jyotshna&rft.aulast=Lantz-McPeak&rft.aufirst=Susan&rft.date=2015-03-01&rft.volume=35&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Screening; Toxicants; Embryonic development; Teratogens; Toxicity; Freshwater fish; Mortality causes; Abiotic factors; Risk assessment; Temperature effects; Mortality; Microscopes; Models; Nicotine; Dimethyl sulfoxide; Ketamine; Caffeine; Embryos; Teratogenicity; Ethanol; Temperature; Assays; Biological effects; Danio rerio; USA DO - http://dx.doi.org/10.1002/jat.3029 ER - TY - JOUR T1 - Biomarkers of brevetoxin exposure and composite toxin levels in hard clam (Mercenaria sp.) exposed to Karenia brevis blooms. AN - 1658420322; 25620222 AB - Brevetoxins in clams (Mercenaria sp.) exposed to recurring blooms of Karenia brevis in Sarasota Bay, FL, were studied over a three-year period. Brevetoxin profiles in toxic clams were generated by ELISA and LC-MS. Several brevetoxin metabolites, as identified by LC-MS, were major contributors to the composite brevetoxin response of ELISA. These were S-desoxyBTX-B2 (m/z 1018), BTX-B2 (m/z 1034), BTX-B5 (m/z 911), open A-ring BTX-B5 (m/z 929), and BTX-B1 (m/z 1018). Summed values of these metabolites were highly correlated (R(2) = 0.9) with composite B-type brevetoxin measurements by ELISA. S-desoxyBTX-B2, BTX-B2, and BTX-B1 were the most persistent and detectable in shellfish for several months after dissipation of blooms. These metabolites were selected as LC-MS biomarkers of brevetoxin exposure and reflective of composite B-type brevetoxins in hard clam. ELISA and LC-MS values were moderately correlated with toxicity of the shellfish by mouse bioassay. ELISA and LC-MS methods offer rapid screening and confirmatory determination of brevetoxins, respectively, as well as toxicity assessment in clams exposed to K. brevis blooms. Published by Elsevier Ltd. JF - Toxicon : official journal of the International Society on Toxinology AU - Abraham, Ann AU - El Said, Kathleen R AU - Wang, Yuesong AU - Jester, Edward L E AU - Plakas, Steven M AU - Flewelling, Leanne J AU - Henry, Michael S AU - Pierce, Richard H AD - FDA, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL 36528, USA. Electronic address: ann.abraham@fda.hhs.gov. ; FDA, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL 36528, USA. ; Fish and Wildlife Research Institute, 100 Eighth Avenue SE, St. Petersburg, FL 33701, USA. ; Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 82 EP - 88 VL - 96 KW - Biomarkers KW - 0 KW - Marine Toxins KW - Oxocins KW - brevetoxin KW - 98225-48-0 KW - Index Medicus KW - Brevetoxins KW - Karenia brevis KW - Hard clams KW - Molecular Structure KW - Mass Spectrometry KW - Animals KW - Chromatography, Liquid KW - Biological Assay KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Time Factors KW - Florida KW - Marine Toxins -- analysis KW - Oxocins -- analysis KW - Bivalvia -- drug effects KW - Environmental Exposure KW - Bivalvia -- metabolism KW - Biomarkers -- metabolism KW - Harmful Algal Bloom KW - Oxocins -- toxicity KW - Marine Toxins -- toxicity KW - Dinoflagellida -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658420322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Biomarkers+of+brevetoxin+exposure+and+composite+toxin+levels+in+hard+clam+%28Mercenaria+sp.%29+exposed+to+Karenia+brevis+blooms.&rft.au=Abraham%2C+Ann%3BEl+Said%2C+Kathleen+R%3BWang%2C+Yuesong%3BJester%2C+Edward+L+E%3BPlakas%2C+Steven+M%3BFlewelling%2C+Leanne+J%3BHenry%2C+Michael+S%3BPierce%2C+Richard+H&rft.aulast=Abraham&rft.aufirst=Ann&rft.date=2015-03-01&rft.volume=96&rft.issue=&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=1879-3150&rft_id=info:doi/10.1016%2Fj.toxicon.2015.01.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-17 N1 - Date created - 2015-02-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxicon.2015.01.014 ER - TY - JOUR T1 - Abnormalities in the male reproductive system after exposure to diesel and biodiesel blend. AN - 1658420177; 25327512 AB - Altering the fuel source from petroleum-based ultralow sulfur diesel to biodiesel and its blends is considered by many to be a sustainable choice for controlling exposures to particulate material. As the exhaust of biodiesel/diesel blends is composed of a combination of combustion products of polycyclic aromatic hydrocarbons and fatty acid methyl esters, we hypothesize that 50% biodiesel/diesel blend (BD50) exposure could induce harmful outcomes because of its ability to trigger oxidative damage. Here, adverse effects were compared in murine male reproductive organs after pharyngeal aspiration with particles generated by engine fueled with BD50 or neat petroleum diesel (D100). When compared with D100, exposure to BD50 significantly altered sperm integrity, including concentration, motility, and morphological abnormalities, as well as increasing testosterone levels in testes during the time course postexposure. Serum level of luteinizing hormone was significantly depleted only after BD50 exposure. Moreover, we observed that exposure to BD50 significantly increased sperm DNA fragmentation and the upregulation of inflammatory cytokines in the serum and testes on Day 7 postexposure when compared with D100. Histological evaluation of testes sections from BD50 exposure indicated more noticeable interstitial edema, degenerating spermatocytes, and dystrophic seminiferous tubules with arrested spermatogenesis. Significant differences in the level of oxidative stress assessed by accumulation of lipid peroxidation products and depletion of glutathione were detected on exposure to respirable BD50 and D100. Taken together, these results indicate that exposure of mice to inhalable BD50 caused more pronounced adverse effects on male reproductive function than diesel. © 2014 Wiley Periodicals, Inc. JF - Environmental and molecular mutagenesis AU - Kisin, Elena R AU - Yanamala, Naveena AU - Farcas, Mariana T AU - Gutkin, Dmitriy W AU - Shurin, Michael R AU - Kagan, Valerian E AU - Bugarski, Aleksandar D AU - Shvedova, Anna A AD - Pathology and Physiology Research Branch, and Exposure Assessment Branch, HELD, NIOSH, Morgantown, West Virginia. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 265 EP - 276 VL - 56 IS - 2 KW - Biofuels KW - 0 KW - Gasoline KW - Petroleum KW - Vehicle Emissions KW - Index Medicus KW - biodiesel particles KW - DNA fragmentation KW - male reproduction KW - sperm quality KW - pulmonary exposure KW - oxidative stress KW - Animals KW - Vehicle Emissions -- toxicity KW - Testis -- drug effects KW - Humans KW - Gasoline -- adverse effects KW - DNA Fragmentation -- drug effects KW - Petroleum -- adverse effects KW - Mice KW - Male KW - Biofuels -- adverse effects KW - Reproduction -- drug effects KW - Spermatozoa -- drug effects KW - Oxidative Stress -- drug effects KW - Lipid Peroxidation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658420177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Abnormalities+in+the+male+reproductive+system+after+exposure+to+diesel+and+biodiesel+blend.&rft.au=Kisin%2C+Elena+R%3BYanamala%2C+Naveena%3BFarcas%2C+Mariana+T%3BGutkin%2C+Dmitriy+W%3BShurin%2C+Michael+R%3BKagan%2C+Valerian+E%3BBugarski%2C+Aleksandar+D%3BShvedova%2C+Anna+A&rft.aulast=Kisin&rft.aufirst=Elena&rft.date=2015-03-01&rft.volume=56&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.21915 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-22 N1 - Date created - 2015-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/em.21915 ER - TY - JOUR T1 - Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease. AN - 1658419024; 25582460 AB - Sickle cell disease (SCD), a hereditary hemolytic disorder is characterized by chronic hemolysis, oxidative stress, vaso-occlusion and end-organ damage. Hemolysis releases toxic cell-free hemoglobin (Hb) into circulation. Under physiologic conditions, plasma Hb binds to haptoglobin (Hp) and forms Hb-Hp dimers. The dimers bind to CD163 receptors on macrophages for further internalization and degradation. However, in SCD patients plasma Hp is depleted and free Hb is cleared primarily by proximal tubules of kidneys. Excess free Hb in plasma predisposes patients to renal damage. We hypothesized that administration of exogenous Hp reduces Hb-mediated renal damage. To test this hypothesis, human renal proximal tubular cells (HK-2) were exposed to HbA (50μM heme) for 24h. HbA increased the expression of heme oxygenase-1 (HO-1), an enzyme which degrades heme, reduces heme-mediated oxidative toxicity, and confers cytoprotection. Similarly, infusion of HbA (32μM heme/kg) induced HO-1 expression in kidneys of SCD mice. Immunohistochemistry confirmed the increased HO-1 expression in the proximal tubules of the kidney. Exogenous Hp attenuated the HbA-induced HO-1 expression in vitro and in SCD mice. Our results suggest that Hb-mediated oxidative toxicity may contribute to renal damage in SCD and that Hp treatment reduces heme/iron toxicity in the kidneys following hemolysis. Published by Elsevier Inc. JF - Blood cells, molecules & diseases AU - Chintagari, Narendranath Reddy AU - Nguyen, Julia AU - Belcher, John D AU - Vercellotti, Gregory M AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. ; University of Minnesota, Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Minneapolis, MN 55455, USA. ; Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. Electronic address: abdu.alayash@fda.hhs.gov. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 302 EP - 306 VL - 54 IS - 3 KW - Haptoglobins KW - 0 KW - Hemoglobin A KW - 9034-51-9 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Index Medicus KW - Kidney proximal tubules KW - Haptoglobin KW - Kidney damage KW - Sickle cell disease KW - Hemeoxygenase-1 KW - Animals KW - Kidney Tubules -- pathology KW - Kidney Tubules -- cytology KW - Humans KW - Oxidative Stress KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Male KW - Female KW - Cell Line KW - Kidney -- metabolism KW - Kidney -- pathology KW - Anemia, Sickle Cell -- metabolism KW - Heme Oxygenase-1 -- metabolism KW - Anemia, Sickle Cell -- complications KW - Hemoglobin A -- metabolism KW - Haptoglobins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658419024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood+cells%2C+molecules+%26+diseases&rft.atitle=Haptoglobin+attenuates+hemoglobin-induced+heme+oxygenase-1+in+renal+proximal+tubule+cells+and+kidneys+of+a+mouse+model+of+sickle+cell+disease.&rft.au=Chintagari%2C+Narendranath+Reddy%3BNguyen%2C+Julia%3BBelcher%2C+John+D%3BVercellotti%2C+Gregory+M%3BAlayash%2C+Abdu+I&rft.aulast=Chintagari&rft.aufirst=Narendranath&rft.date=2015-03-01&rft.volume=54&rft.issue=3&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Blood+cells%2C+molecules+%26+diseases&rft.issn=1096-0961&rft_id=info:doi/10.1016%2Fj.bcmd.2014.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-23 N1 - Date created - 2015-02-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Blood. 2013 Mar 14;121(11):2099-107 [23349388] Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12150-4 [1465454] Cold Spring Harb Perspect Med. 2013 Jun;3(6). pii: a013433. doi: 10.1101/cshperspect.a013433 [23645855] Am J Physiol Lung Cell Mol Physiol. 2014 Jan 1;306(1):L88-100 [24142518] Blood. 2014 Jan 16;123(3):377-90 [24277079] Free Radic Biol Med. 2014 Apr;69:265-77 [24486321] Trends Biotechnol. 2014 Apr;32(4):177-85 [24630491] J Biol Chem. 2014 Aug 8;289(32):22342-57 [24939847] JAMA. 2014 Nov 26;312(20):2115-25 [25393378] J Clin Invest. 2006 Mar;116(3):808-16 [16485041] J Clin Invest. 2007 Apr;117(4):850-8 [17404610] Blood. 2009 Mar 12;113(11):2578-86 [19131549] J Clin Invest. 2009 Aug;119(8):2271-80 [19620788] J Biol Chem. 2009 Oct 23;284(43):29582-95 [19700768] Annu Rev Pharmacol Toxicol. 2010;50:323-54 [20055707] Eur J Haematol. 2010 Jan 1;84(1):72-8 [19732137] PLoS One. 2010;5(2):e9228 [20169059] PLoS One. 2010;5(11):e14171 [21152393] Clin Chim Acta. 2011 Mar 18;412(7-8):493-8 [21159311] Science. 2011 Dec 2;334(6060):1283-6 [22075726] Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):421-6 [22138393] J Clin Invest. 2012 Apr;122(4):1444-58 [22446185] J Am Soc Nephrol. 2012 May;23(5):781-4 [22440903] Br J Haematol. 2012 Jun;157(5):599-605 [22409346] J Biol Chem. 2013 Feb 8;288(6):4288-98 [23264625] J Am Soc Nephrol. 2002 Feb;13(2):423-30 [11805171] Nat Med. 2002 Dec;8(12):1383-9 [12426562] Blood. 2003 May 15;101(10):3953-9 [12543857] J Biol Chem. 1968 Feb 10;243(3):465-75 [4966113] Blood. 1968 Nov;32(5):811-5 [5687939] Proc Natl Acad Sci U S A. 1988 Jan;85(1):237-41 [3422420] PLoS One. 2013;8(3):e59841 [23555800] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bcmd.2014.12.001 ER - TY - JOUR T1 - (Q)SAR assessments of potentially mutagenic impurities: a regulatory perspective on the utility of expert knowledge and data submission. AN - 1658416389; 25545315 AB - (Quantitative) structure activity relationship [(Q)SAR] modeling is the primary tool used to evaluate the mutagenic potential associated with drug impurities. General recommendations regarding the use of (Q)SAR in regulatory decision making have recently been provided in the ICH M7 guideline. Although (Q)SAR alone is capable of achieving reasonable sensitivity and specificity, reliance on a simple positive or negative prediction can be problematic. The key to improving (Q)SAR performance is to integrate supporting information, also referred to as expert knowledge, into the final conclusion. In the regulatory context, expert knowledge is intended to (1) maximize confidence in a (Q)SAR prediction, (2) provide rationale to supersede a positive or negative (Q)SAR prediction, or (3) provide a basis for assessing mutagenicity in absence of a (Q)SAR prediction. Expert knowledge is subjective and is associated with great variability in regards to content and quality. However, it is still a critical component of impurity evaluations and its utility is acknowledged in the ICH M7 guideline. The current paper discusses the use of expert knowledge to support regulatory decision making, describes case studies, and provides recommendations for reporting data from (Q)SAR evaluations. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Powley, Mark W AD - Division of Antiviral Products, Office of New Drugs, Center for Drug Evaluation and Research, US FDA, WO 22/RM 6389, 10903 New Hampshire Ave., Silver Spring, MD 20993, United States. Electronic address: mark.powley@fda.hhs.gov. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 295 EP - 300 VL - 71 IS - 2 KW - Mutagens KW - 0 KW - Index Medicus KW - ICH M7 KW - Mutagenicity KW - (Q)SAR KW - Drug impurities KW - Humans KW - Mutagenicity Tests -- standards KW - Drug Contamination -- prevention & control KW - Quantitative Structure-Activity Relationship KW - Databases, Factual -- legislation & jurisprudence KW - Expert Systems KW - Drug Contamination -- legislation & jurisprudence KW - Databases, Factual -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658416389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=%28Q%29SAR+assessments+of+potentially+mutagenic+impurities%3A+a+regulatory+perspective+on+the+utility+of+expert+knowledge+and+data+submission.&rft.au=Powley%2C+Mark+W&rft.aulast=Powley&rft.aufirst=Mark&rft.date=2015-03-01&rft.volume=71&rft.issue=2&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.12.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.12.012 ER - TY - JOUR T1 - Estimation of the chemical-induced eye injury using a Weight-of-Evidence (WoE) battery of 21 artificial neural network (ANN) c-QSAR models (QSAR-21): part II: corrosion potential. AN - 1658416295; 25510831 AB - This is part II of an in silico investigation of chemical-induced eye injury that was conducted at FDA's CFSAN. Serious eye damage caused by chemical (eye corrosion) is assessed using the rabbit Draize test, and this endpoint is an essential part of hazard identification and labeling of industrial and consumer products to ensure occupational and consumer safety. There is an urgent need to develop an alternative to the Draize test because EU's 7th amendment to the Cosmetic Directive (EC, 2003; 76/768/EEC) and recast Regulation now bans animal testing on all cosmetic product ingredients and EU's REACH Program limits animal testing for chemicals in commerce. Although in silico methods have been reported for eye irritation (reversible damage), QSARs specific for eye corrosion (irreversible damage) have not been published. This report describes the development of 21 ANN c-QSAR models (QSAR-21) for assessing eye corrosion potential of chemicals using a large and diverse CFSAN data set of 504 chemicals, ADMET Predictor's three sensitivity analyses and ANNE classification functionalities with 20% test set selection from seven different methods. QSAR-21 models were internally and externally validated and exhibited high predictive performance: average statistics for the training, verification, and external test sets of these models were 96/96/94% sensitivity and 91/91/90% specificity. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Verma, Rajeshwar P AU - Matthews, Edwin J AD - Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, United States; Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, United States. Electronic address: Rajeshwar.Verma@fda.hhs.gov. ; Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, United States. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 331 EP - 336 VL - 71 IS - 2 KW - Caustics KW - 0 KW - Cosmetics KW - Index Medicus KW - c-QSAR KW - QSAR-21 KW - Artificial neural network KW - Eye corrosion KW - Weight of evidence KW - Animals KW - Rabbits KW - Caustics -- administration & dosage KW - Quantitative Structure-Activity Relationship KW - Neural Networks (Computer) KW - Cosmetics -- administration & dosage KW - Animal Testing Alternatives -- methods KW - Caustics -- toxicity KW - Eye Injuries -- chemically induced KW - Cosmetics -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658416295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Estimation+of+the+chemical-induced+eye+injury+using+a+Weight-of-Evidence+%28WoE%29+battery+of+21+artificial+neural+network+%28ANN%29+c-QSAR+models+%28QSAR-21%29%3A+part+II%3A+corrosion+potential.&rft.au=Verma%2C+Rajeshwar+P%3BMatthews%2C+Edwin+J&rft.aulast=Verma&rft.aufirst=Rajeshwar&rft.date=2015-03-01&rft.volume=71&rft.issue=2&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.12.004 ER - TY - JOUR T1 - Hep-2 cell based indirect immunofluorescence assay for antinuclear antibodies as a potential diagnosis of drug-induced autoimmunity in nonclinical toxicity testing. AN - 1658416265; 25455225 AB - Antinuclear antibodies (ANAs) are important biomarkers in the diagnosis of autoimmune diseases in humans; however, the diagnostic performance of ANA in nonclinical safety studies are not well understood. Here, we studied the use of ANAs as potential nonclinical biomarkers for drug-induced autoimmunity (DIA) using a Hep-2 based indirect immunofluorescence assay (IFA). Initially, MRL-fas(lpr)/J mice and HgCl₂-treated rats were used as SLE-positive models. Serum samples obtained from 94 normal mice or 204 normal rats aged one to four months served as the negative control. The IFA effectively distinguished ANAs-positive samples in both species with a cut-off titer of 1:100. Brown Norway rats were treated with 450 mg/kg D-penicillamine for 30 consecutive days. ANAs were generated and corresponded with DIA development. Human Hep-2 cells, mice Neuro 2A cells, and Chinese Hamster Lung cells served as antigen from different species, which were found cross-reactive with ANA-positive serum samples from mice, rats, and humans without any differences in diagnosis. This methodology showed no species-specificity for ANA detection. Furthermore, we found approximately 20 percentage of the mice aged seven to eight months demonstrated age-related ANAs, which was consistent with humans. Overall, our findings demonstrated the use of ANA detection using IFA in the nonclinical diagnosis of murine drug-induced autoimmunity, and age-related ANAs should be considered when aged animals are used. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Hong, Min AU - Ma, Ben AU - Lin, Zhi AU - Zhou, Xiaobing AU - Geng, Xingchao AU - Shen, Lianzhong AU - Li, Bo AD - National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, China Food and Drug Administration, 100176 Beijing, People's Republic of China. ; National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, China Food and Drug Administration, 100176 Beijing, People's Republic of China. Electronic address: libo@nifdc.org.cn. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 141 EP - 147 VL - 71 IS - 2 KW - Antibodies, Antinuclear KW - 0 KW - Index Medicus KW - Drug-induced autoimmunity (DIA) KW - Age-related ANAs KW - Biomarker KW - Antinuclear antibodies (ANAs) KW - Animals KW - Cricetulus KW - Humans KW - Cell Line, Tumor KW - Mice KW - Rats, Inbred BN KW - Mice, Inbred BALB C KW - Rats KW - Fluorescent Antibody Technique, Indirect -- methods KW - Hep G2 Cells KW - Rats, Wistar KW - Microscopy, Fluorescence -- methods KW - Female KW - Male KW - Cricetinae KW - Autoimmunity -- immunology KW - Autoimmunity -- drug effects KW - Toxicity Tests -- methods KW - Antibodies, Antinuclear -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658416265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Hep-2+cell+based+indirect+immunofluorescence+assay+for+antinuclear+antibodies+as+a+potential+diagnosis+of+drug-induced+autoimmunity+in+nonclinical+toxicity+testing.&rft.au=Hong%2C+Min%3BMa%2C+Ben%3BLin%2C+Zhi%3BZhou%2C+Xiaobing%3BGeng%2C+Xingchao%3BShen%2C+Lianzhong%3BLi%2C+Bo&rft.aulast=Hong&rft.aufirst=Min&rft.date=2015-03-01&rft.volume=71&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.10.005 ER - TY - JOUR T1 - Relationship between ambient ultraviolet radiation and non-Hodgkin lymphoma subtypes: A U.S. population-based study of racial and ethnic groups AN - 1654666065; 21180146 AB - Associations between ultraviolet radiation (UVR) exposure and non-Hodgkin lymphoma (NHL) have been inconsistent, but few studies have examined these associations for specific subtypes or across race/ethnicities. We evaluated the relationship between ambient UVR exposure and subtype-specific NHL incidence for whites, Hispanics and blacks in the United States for years 2001-2010 (n=187,778 cases). Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quintiles using Poisson regression. Incidence was lower for the highest UVR quintile for chronic/small lymphocytic/leukemia (CLL/SLL) (IRR=0.87, 95% CI: 0.77-0.97), mantle cell (IRR=0.82, 95% CI: 0.69-0.97), lymphoplasmacytic (IRR=0.58, 95% CI: 0.42-0.80), mucosa-associated lymphoid tissue (MZLMALT) (IRR=0.74, 95% CI: 0.60-0.90), follicular (FL) (IRR=0.76, 95% CI: 0.68-0.86), diffuse large B-cell (IRR=0.84, 95% CI: 0.76-0.94; ), peripheral T-cell other (PTCL) (IRR=0.76, 95% CI: 0.61-0.95) and PTCL not otherwise specified (PNOS) (IRR=0.77, 95% CI: 0.61-0.98). Trends were significant for MZLMALT, FL, DLBCL, BNOS and PTCL, with FL and DLBCL still significant after Bonferroni correction. We found interaction by race/ethnicity for CLL/SLL, FL, Burkitt, PNOS and MF/SS, with CLL/SLL and FL still significant after Bonferroni correction. Some B-cell lymphomas (CLL/SLL, FL and Burkitt) suggested significant inverse relationships in whites and Hispanics, but not in blacks. Some T-cell lymphomas suggested the most reduced risk for the highest quintile of UVR among blacks (PNOS and MF/SS), though trends were not significant. These findings strengthen the case for an inverse association of UVR exposure, support modest heterogeneity between NHL subtypes and suggest some differences by race/ethnicity. What's new? Studies have yielded mix results as to whether exposure to ultraviolet radiation (UVR) increases or decreases risk of non-Hodgkin lymphoma (NHL). In the present analysis of data from population-based cancer registries in the United States, increasing ambient UVR exposure was associated with a reduction in risk of most NHL subtypes, The reduction occurred for all races, including non-Hispanic whites, Hispanic whites, and blacks. The findings emphasize the importance of exploring NHL etiology according to subtypes and across races and ethnicities, as NHL is increasingly recognized as comprising a diverse group of cancers, each potentially involving unique mechanisms. JF - International Journal of Cancer AU - Cahoon, Elizabeth K AU - Pfeiffer, Ruth M AU - Wheeler, David C AU - Arhancet, Juan AU - Lin, Shih-Wen AU - Alexander, Bruce H AU - Linet, Martha S AU - Freedman, DMichal AD - Radiation Epidemiology Branch, National Cancer Institute, Division of Cancer Epidemiology and Genetics, U.S. Department of Health and Human Services, National Institutes of Health, Bethesda, MD. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - E432 EP - E441 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 136 IS - 5 SN - 0020-7136, 0020-7136 KW - Health & Safety Science Abstracts; Immunology Abstracts; Risk Abstracts KW - Risk reduction KW - Non-Hodgkin's lymphoma KW - Leukemia KW - U.V. radiation KW - Risk factors KW - Ultraviolet radiation KW - Lymphocytes T KW - Lymphoma KW - Races KW - Ethnic groups KW - B-cell lymphoma KW - Etiology KW - Data processing KW - Lymphocytes B KW - Population studies KW - Race differences KW - Cancer KW - Health risks KW - USA KW - T-cell lymphoma KW - Chronic lymphatic leukemia KW - H 8000:Radiation Safety/Electrical Safety KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654666065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Relationship+between+ambient+ultraviolet+radiation+and+non-Hodgkin+lymphoma+subtypes%3A+A+U.S.+population-based+study+of+racial+and+ethnic+groups&rft.au=Cahoon%2C+Elizabeth+K%3BPfeiffer%2C+Ruth+M%3BWheeler%2C+David+C%3BArhancet%2C+Juan%3BLin%2C+Shih-Wen%3BAlexander%2C+Bruce+H%3BLinet%2C+Martha+S%3BFreedman%2C+DMichal&rft.aulast=Cahoon&rft.aufirst=Elizabeth&rft.date=2015-03-01&rft.volume=136&rft.issue=5&rft.spage=E432&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.29237 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Etiology; B-cell lymphoma; Data processing; Lymphocytes B; Population studies; Race differences; Cancer; Leukemia; U.V. radiation; Risk factors; Lymphocytes T; T-cell lymphoma; Chronic lymphatic leukemia; Ethnic groups; Races; Non-Hodgkin's lymphoma; Health risks; Ultraviolet radiation; Risk reduction; Lymphoma; USA DO - http://dx.doi.org/10.1002/ijc.29237 ER - TY - JOUR T1 - Tween-80 and impurity induce anaphylactoid reaction in zebrafish. AN - 1652429972; 25345596 AB - A number of recent reports suspected that Tween-80 in injectable medicines, including traditional Chinese medicine injections could cause life-threatening anaphylactoid reaction, but no sound conclusion was drawn. A drug-induced anaphylactoid reaction is hard to be assayed in vitro and in conventional animal models. In this study, we developed a microplate-based quantitative in vivo zebrafish assay for assessing anaphylactoid reaction and live whole zebrafish mast cell tryptase activity was quantitatively measured at a wavelength of 405 nm using N-benzoyl-dl-arginine p-nitroanilide as a substrate. We assessed 10 batches of Tween-80 solutions from various national and international suppliers and three Tween-80 impurities (ethylene glycol, 2-chloroethanol and hydrogen peroxide) in this model and found that three batches of Tween-80 (nos 2, 20080709 and 20080616) and one Tween-80 impurity, hydrogen peroxide (H2 O2 ), induced anaphylactoid reactions in zebrafish. Furthermore, we found that H2 O2 residue and peroxide value were much higher in Tween-80 samples 2, 20080709 and 20080616. These findings suggest that H2 O2 residue in combination with oxidized fatty acid residues (measured as peroxide value) or more likely the oxidized fatty acid residues in Tween-80 samples, but not Tween-80 itself, may induce anaphylactoid reaction. High-throughput zebrafish tryptase assay developed in this report could be used for assessing safety of Tween-80-containing injectable medicines and potentially for screening novel mast cell-modulating drugs. Copyright © 2014 John Wiley & Sons, Ltd. JF - Journal of applied toxicology : JAT AU - Yang, Rui AU - Lao, Qiao-Cong AU - Yu, Hang-Ping AU - Zhang, Yong AU - Liu, Hong-Cui AU - Luan, Lin AU - Sun, Hui-Min AU - Li, Chun-Qi AD - National Institutes for Food and Drug Control, China Food and Drug Administration (CFDA), No. 2 Tiantan Xili, Dongcheng District, Beijing, 100050, China. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 295 EP - 301 VL - 35 IS - 3 KW - Drugs, Chinese Herbal KW - 0 KW - Excipients KW - Polysorbates KW - Ethylene Chlorohydrin KW - 753N66IHAN KW - Hydrogen Peroxide KW - BBX060AN9V KW - Tryptases KW - EC 3.4.21.59 KW - Ethylene Glycol KW - FC72KVT52F KW - Index Medicus KW - tryptase KW - zebrafish KW - impurity KW - Tween-80 KW - anaphylactoid reaction KW - Tryptases -- metabolism KW - Hydrogen Peroxide -- toxicity KW - Ethylene Glycol -- chemistry KW - High-Throughput Screening Assays KW - Ethylene Chlorohydrin -- toxicity KW - Animals KW - Intestines -- drug effects KW - Ethylene Chlorohydrin -- chemistry KW - Ethylene Glycol -- toxicity KW - Mast Cells -- drug effects KW - Drugs, Chinese Herbal -- administration & dosage KW - Hydrogen Peroxide -- chemistry KW - Zebrafish -- immunology KW - Excipients -- toxicity KW - Drug Contamination KW - Anaphylaxis -- chemically induced KW - Anaphylaxis -- enzymology KW - Polysorbates -- toxicity KW - Excipients -- chemistry KW - Polysorbates -- chemistry KW - Anaphylaxis -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652429972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Tween-80+and+impurity+induce+anaphylactoid+reaction+in+zebrafish.&rft.au=Yang%2C+Rui%3BLao%2C+Qiao-Cong%3BYu%2C+Hang-Ping%3BZhang%2C+Yong%3BLiu%2C+Hong-Cui%3BLuan%2C+Lin%3BSun%2C+Hui-Min%3BLi%2C+Chun-Qi&rft.aulast=Yang&rft.aufirst=Rui&rft.date=2015-03-01&rft.volume=35&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3069 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-05 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3069 ER - TY - JOUR T1 - Anesthetic neurotoxicity--clinical implications of animal models. AN - 1659770874; 25714157 AB - Some anesthetics and sedatives have been shown to cause neurotoxic effects in laboratory animals. The FDA collaboration SmartTots recommends undertaking large-scale clinical studies and avoiding nonurgent surgical procedures requiring anesthesia in children younger than 3 years of age. JF - The New England journal of medicine AU - Rappaport, Bob A AU - Suresh, Santhanam AU - Hertz, Sharon AU - Evers, Alex S AU - Orser, Beverley A AD - From the Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD (B.A.R., S.H.); Northwestern University Feinberg School of Medicine, Chicago (S.S.); Washington University School of Medicine, St. Louis (A.S.E.); and the Department of Anesthesia and Physiology, University of Toronto, Toronto (B.A.O.). Y1 - 2015/02/26/ PY - 2015 DA - 2015 Feb 26 SP - 796 EP - 797 VL - 372 IS - 9 KW - Anesthetics KW - 0 KW - Hypnotics and Sedatives KW - Receptors, GABA KW - Receptors, Glutamate KW - Abridged Index Medicus KW - Index Medicus KW - Receptors, GABA -- drug effects KW - Animals KW - Postoperative Complications KW - Receptors, Glutamate -- drug effects KW - Humans KW - Child, Preschool KW - Models, Animal KW - Brain -- drug effects KW - Anesthetics -- adverse effects KW - Practice Guidelines as Topic KW - Surgical Procedures, Operative KW - Hypnotics and Sedatives -- adverse effects KW - Learning Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1659770874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Anesthetic+neurotoxicity--clinical+implications+of+animal+models.&rft.au=Rappaport%2C+Bob+A%3BSuresh%2C+Santhanam%3BHertz%2C+Sharon%3BEvers%2C+Alex+S%3BOrser%2C+Beverley+A&rft.aulast=Rappaport&rft.aufirst=Bob&rft.date=2015-02-26&rft.volume=372&rft.issue=9&rft.spage=796&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMp1414786 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-11 N1 - Date created - 2015-02-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1056/NEJMp1414786 ER - TY - JOUR T1 - Suppression of CYP2C9 by microRNA hsa-miR-128-3p in human liver cells and association with hepatocellular carcinoma. AN - 1658420585; 25704921 AB - Published studies have identified genetic variants, somatic mutations, and changes in gene expression profiles that are associated with hepatocellular carcinoma (HCC), particularly involving genes that encode drug metabolizing enzymes (DMEs). CYP2C9, one of the most abundant and important DMEs, is involved in the metabolism of many carcinogens and drugs and is down-regulated in HCC. To investigate the molecular mechanisms that control CYP2C9 expression, we applied integrative approaches including in silico, in vitro, and in vivo analyses to elucidate the role of microRNA hsa-miR-128-3p in the regulation of CYP2C9 expression and translation. RNA electrophoresis mobility shift assays demonstrated a direct interaction between hsa-miR-128-3p and its cognate target, the CYP2C9 transcript. Furthermore, the expression of a luciferase reporter gene containing the 3'-UTR of CYP2C9 and the endogenous expression of CYP2C9 were suppressed by transfection of hsa-miR-128-3p. Importantly, chemically-induced up- or down-regulation of hsa-miR-128-3p correlated inversely with the expression of CYP2C9. Finally, an association analysis revealed that the expression of hsa-miR-128-3p is inversely correlated with the expression of CYP2C9 in HCC tumor tissues. Altogether, the study helped to elucidate the mechanism of CYP2C9 regulation by hsa-miR-128-3p, and the inverse association in HCC. JF - Scientific reports AU - Yu, Dianke AU - Green, Bridgett AU - Marrone, April AU - Guo, Yongli AU - Kadlubar, Susan AU - Lin, Dongxin AU - Fuscoe, James AU - Pogribny, Igor AU - Ning, Baitang AD - 1] National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA [2] State Key Laboratory of Molecular Oncology and Department of Etiology &Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 100021. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Beijing Children's Hospital, Capital Medical University, Beijing, China 100045. ; University of Arkansas for Medical Sciences, AR 72205, USA. ; State Key Laboratory of Molecular Oncology and Department of Etiology &Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 100021. Y1 - 2015/02/23/ PY - 2015 DA - 2015 Feb 23 SP - 8534 VL - 5 KW - 3' Untranslated Regions KW - 0 KW - MIRN128 microRNA, human KW - MIRN143 microRNA, human KW - MicroRNAs KW - RNA, Messenger KW - Zalcitabine KW - 6L3XT8CB3I KW - Cytochrome P-450 CYP2C9 KW - EC 1.14.13.- KW - Index Medicus KW - Base Sequence KW - Sequence Alignment KW - RNA, Messenger -- metabolism KW - Hep G2 Cells KW - Humans KW - HEK293 Cells KW - Up-Regulation -- drug effects KW - Electrophoretic Mobility Shift Assay KW - RNA, Messenger -- analysis KW - Zalcitabine -- pharmacology KW - Down-Regulation -- drug effects KW - Liver Neoplasms -- pathology KW - MicroRNAs -- metabolism KW - Cytochrome P-450 CYP2C9 -- metabolism KW - Cytochrome P-450 CYP2C9 -- chemistry KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - Liver -- metabolism KW - Cytochrome P-450 CYP2C9 -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658420585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Suppression+of+CYP2C9+by+microRNA+hsa-miR-128-3p+in+human+liver+cells+and+association+with+hepatocellular+carcinoma.&rft.au=Yu%2C+Dianke%3BGreen%2C+Bridgett%3BMarrone%2C+April%3BGuo%2C+Yongli%3BKadlubar%2C+Susan%3BLin%2C+Dongxin%3BFuscoe%2C+James%3BPogribny%2C+Igor%3BNing%2C+Baitang&rft.aulast=Yu&rft.aufirst=Dianke&rft.date=2015-02-23&rft.volume=5&rft.issue=&rft.spage=8534&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep08534 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-02 N1 - Date created - 2015-02-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Biomed Pharmacother. 2010 Jul;64(6):399-408 [20363096] Toxicol Sci. 2010 Dec;118(2):391-403 [20881232] Drug Metab Dispos. 2011 Mar;39(3):528-38 [21149542] Curr Mol Med. 2011 Mar;11(2):93-109 [21342132] Mol Cell Biochem. 2011 Apr;350(1-2):207-13 [21197560] Carcinogenesis. 2012 Jan;33(1):94-100 [22016467] Med Oncol. 2012 Jun;29(2):1242-8 [21264530] Cell Death Differ. 2012 Jun;19(6):1038-48 [22193543] Annu Rev Pharmacol Toxicol. 2013;53:377-400 [23189953] Oncogene. 2013 Mar 28;32(13):1651-9 [22614013] PLoS One. 2013;8(4):e60368 [23637747] Urol Oncol. 2013 Aug;31(6):796-801 [21880514] Exp Cell Res. 2013 Dec 10;319(20):3059-64 [23958464] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014;32(2):121-58 [24875441] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):3-28 [10667460] Cancer Res. 2001 Mar 1;61(5):2129-37 [11280777] Carcinogenesis. 2001 Aug;22(8):1323-6 [11470765] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15089-94 [11752456] Mol Biol Cell. 2002 Jun;13(6):1929-39 [12058060] Int J Cancer. 2003 Apr 10;104(3):310-7 [12569554] Cancer Res. 2003 Feb 15;63(4):859-64 [12591738] Hepatology. 2004 Feb;39(2):518-27 [14768006] Clin Gastroenterol Hepatol. 2004 Aug;2(8):704-12 [15290664] Mol Cell Proteomics. 2010 Feb;9(2):298-312 [19955085] Cancer Res. 2008 Nov 15;68(22):9125-30 [19010882] J Biomol Screen. 2008 Mar;13(3):194-201 [18270363] Gastroenterology. 2007 Jun;132(7):2557-76 [17570226] Nat Rev Cancer. 2006 Dec;6(12):947-60 [17128211] Nat Rev Cancer. 2006 Nov;6(11):857-66 [17060945] Cancer Res. 2006 Sep 15;66(18):9090-8 [16982751] Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R17-29 [16651366] Mol Carcinog. 1994 Jul;10(3):159-68 [8043197] Int J Oncol. 2005 Sep;27(3):661-7 [16077914] Carcinogenesis. 1999 Jun;20(6):991-5 [10357778] Br J Clin Pharmacol. 1998 Jun;45(6):525-38 [9663807] Hepatology. 1998 Feb;27(2):427-32 [9462641] Pharmacogenetics. 1997 Oct;7(5):401-4 [9352577] Am J Hum Genet. 1997 Feb;60(2):265-71 [9012398] DNA Cell Biol. 1996 Apr;15(4):273-80 [8639263] Pharmacogenetics. 1994 Dec;4(6):285-99 [7704034] Chem Res Toxicol. 1995 Jan-Feb;8(1):136-42 [7703357] RNA. 2004 Oct;10(10):1507-17 [15383676] Gastroenterology. 2004 Nov;127(5 Suppl 1):S72-8 [15508106] Drug Metab Dispos. 2006 Jan;34(1):75-83 [16204462] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep08534 ER - TY - JOUR T1 - Detection of Foodborne Bacterial Pathogens from Individual Filth Flies AN - 1687678668; PQ0001339726 AB - There is unanimous consensus that insects are important vectors of foodborne pathogens. However, linking insects as vectors of the pathogen causing a particular foodborne illness outbreak has been challenging. This is because insects are not being aseptically collected as part of an environmental sampling program during foodborne outbreak investigations and because there is not a standardized method to detect foodborne bacteria from individual insects. To take a step towards solving this problem, we adapted a protocol from a commercially available PCR-based system that detects foodborne pathogens from food and environmental samples, to detect foodborne pathogens from individual flies.Using this standardized protocol, we surveyed 100 wild-caught flies for the presence of Cronobacter spp., Salmonella enterica, and Listeria monocytogenes and demonstrated that it was possible to detect and further isolate these pathogens from the body surface and the alimentary canal of a single fly. Twenty-two percent of the alimentary canals and 8% of the body surfaces from collected wild flies were positive for at least one of the three foodborne pathogens. The prevalence of Cronobacter spp. on either body part of the flies was statistically higher (19%) than the prevalence of S. enterica (7%) and L.monocytogenes (4%). No false positives were observed when detecting S. enterica and L. monocytogenes using this PCR-based system because pure bacterial cultures were obtained from all PCR-positive results. However, pure Cronobacter colonies were not obtained from about 50% of PCR-positive samples, suggesting that the PCR-based detection system for this pathogen cross-reacts with other Enterobacteriaceae present among the highly complex microbiota carried by wild flies. The standardized protocol presented here will allow laboratories to detect bacterial foodborne pathogens from aseptically collected insects, thereby giving public health officials another line of evidence to find out how the food was contaminated when performing foodborne outbreak investigations. JF - Journal of Visualized Experiments AU - Pava-Ripoll, Monica AU - Pearson, Rachel EG AU - Miller, Amy K AU - Ziobro, George C AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration Y1 - 2015/02/13/ PY - 2015 DA - 2015 Feb 13 PB - Journal of Visualized Experiments, 48 Grove St. Somerville, MA 02144 United States IS - 96 KW - Microbiology Abstracts B: Bacteriology KW - Environmental Sciences KW - Issue 96 KW - Synanthropy KW - filth flies KW - Cronobacter KW - Listeria monocytogenes KW - Salmonella KW - Escherichia coli O157:H7 KW - shiga-toxigenic E. coli KW - STEC KW - PCR-based methods KW - foodborne illness KW - foodborne outbreak investigations. KW - Bacteria KW - Food KW - Vectors KW - Pathogens KW - Food contamination KW - Public health KW - Canals KW - Colonies KW - Salmonella enterica KW - Sampling KW - Enterobacteriaceae KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687678668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Visualized+Experiments&rft.atitle=Detection+of+Foodborne+Bacterial+Pathogens+from+Individual+Filth+Flies&rft.au=Pava-Ripoll%2C+Monica%3BPearson%2C+Rachel+EG%3BMiller%2C+Amy+K%3BZiobro%2C+George+C&rft.aulast=Pava-Ripoll&rft.aufirst=Monica&rft.date=2015-02-13&rft.volume=&rft.issue=96&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Visualized+Experiments&rft.issn=1940-087X&rft_id=info:doi/10.3791%2F52372 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Canals; Colonies; Food; Vectors; Sampling; Pathogens; Food contamination; Public health; Listeria monocytogenes; Bacteria; Salmonella enterica; Enterobacteriaceae DO - http://dx.doi.org/10.3791/52372 ER - TY - JOUR T1 - Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1). AN - 1655524162; 25548275 AB - Pregnancy-specific glycoproteins (PSGs) are a family of Ig-like proteins secreted by specialized placental cells. The PSG1 structure is composed of a single Ig variable region-like N-terminal domain and three Ig constant region-like domains termed A1, A2, and B2. Members of the human and murine PSG family have been shown to induce anti-inflammatory cytokines from monocytes and macrophages and to stimulate angiogenesis. We recently showed that recombinant forms of PSG1 (PSG1-Fc and PSG1-His) and PSG1 purified from the serum of pregnant women are associated with the immunoregulatory cytokine TGF-β1 and activated latent TGF-β1. Here, we sought to examine the requirement of specific PSG1 domains in the activation of latent TGF-β1. Plasmon surface resonance studies showed that PSG1 directly bound to the small latent complex and to the latency-associated peptide of TGF-β1 and that this binding was mediated through the B2 domain. Furthermore, the B2 domain alone was sufficient for activating the small latent complex. In separate experiments, we found that the PSG1-mediated induction of TGF-β1 secretion in macrophages was dependent on the N-terminal domain. Mutagenesis analysis revealed that four amino acids (LYHY) of the CC' loop of the N-terminal domain were required for induction of latent TGF-β1 secretion. Together, our results show that two distinct domains of PSG1 are involved in the regulation of TGF-β1 and provide a mechanistic framework for how PSGs modulate the immunoregulatory environment at the maternal-fetal interface for successful pregnancy outcome. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. JF - The Journal of biological chemistry AU - Ballesteros, Angela AU - Mentink-Kane, Margaret M AU - Warren, James AU - Kaplan, Gerardo G AU - Dveksler, Gabriela S AD - From the Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 and. ; the Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. ; the Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 gabriela.dveksler@usuhs.edu. Y1 - 2015/02/13/ PY - 2015 DA - 2015 Feb 13 SP - 4422 EP - 4431 VL - 290 IS - 7 KW - Cytokines KW - 0 KW - Pregnancy-Specific beta 1-Glycoproteins KW - RNA, Messenger KW - Transforming Growth Factor beta1 KW - Index Medicus KW - Placenta KW - Surface Plasmon Resonance (SPR) KW - Macrophage KW - Latency-associated Peptide KW - Latent TGF-β1 KW - Heparan Sulfate KW - Pregnancy KW - Real-Time Polymerase Chain Reaction KW - Animals KW - Cytokines -- genetics KW - Humans KW - Cytokines -- metabolism KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Blotting, Western KW - Cells, Cultured KW - Protein Structure, Tertiary KW - Female KW - Immunoenzyme Techniques KW - Protein Conformation KW - Macrophages -- cytology KW - Transforming Growth Factor beta1 -- metabolism KW - Monocytes -- cytology KW - Monocytes -- metabolism KW - Pregnancy-Specific beta 1-Glycoproteins -- genetics KW - Transforming Growth Factor beta1 -- genetics KW - Placenta -- metabolism KW - Placenta -- cytology KW - Pregnancy-Specific beta 1-Glycoproteins -- metabolism KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1655524162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Induction+and+activation+of+latent+transforming+growth+factor-%CE%B21+are+carried+out+by+two+distinct+domains+of+pregnancy-specific+glycoprotein+1+%28PSG1%29.&rft.au=Ballesteros%2C+Angela%3BMentink-Kane%2C+Margaret+M%3BWarren%2C+James%3BKaplan%2C+Gerardo+G%3BDveksler%2C+Gabriela+S&rft.aulast=Ballesteros&rft.aufirst=Angela&rft.date=2015-02-13&rft.volume=290&rft.issue=7&rft.spage=4422&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M114.597518 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-08 N1 - Date created - 2015-02-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Leukoc Biol. 2002 Sep;72(3):512-21 [12223519] Am J Reprod Immunol. 2001 Apr;45(4):205-16 [11327547] J Cell Biol. 2004 Jun 7;165(5):723-34 [15184403] Biol Reprod. 2001 Jan;64(1):90-9 [11133662] J Biol Chem. 1997 Jun 27;272(26):16329-34 [9195938] J Exp Med. 2002 Jan 21;195(2):277-82 [11805154] Br J Obstet Gynaecol. 1979 Nov;86(11):888-90 [315792] Biochemistry. 1982 Oct 26;21(22):5523-8 [6983365] J Virol. 1993 Jan;67(1):1-8 [8380065] Anal Biochem. 1994 Feb 1;216(2):276-84 [8179182] Infect Immun. 1995 Jan;63(1):224-8 [7806361] Genomics. 1994 Oct;23(3):669-84 [7851896] J Clin Invest. 1995 Mar;95(3):1363-9 [7883983] J Immunol. 1996 May 1;156(9):3461-8 [8617974] Placenta. 1997 Sep;18(7):491-501 [9290143] J Clin Invest. 1998 Feb 15;101(4):890-8 [9466984] J Biol Chem. 1999 May 7;274(19):13586-93 [10224129] BMC Genomics. 2005;6:4 [15647114] Bioinformatics. 2006 Jan 15;22(2):195-201 [16301204] Annu Rev Immunol. 2006;24:99-146 [16551245] Nat Rev Immunol. 2006 Jun;6(6):433-46 [16724098] J Leukoc Biol. 2008 Jul;84(1):302-10 [18436584] Electrophoresis. 2009 Jun;30 Suppl 1:S162-73 [19517507] Prenat Diagn. 2009 Dec;29(13):1256-61 [19911417] Infect Immun. 2010 Apr;78(4):1789-96 [20123706] J Biol Chem. 2010 May 7;285(19):14806-14 [20207738] J Biol Chem. 2011 Mar 4;286(9):7577-86 [21193412] Nature. 2011 Jun 16;474(7351):343-9 [21677751] Placenta. 2011 Aug;32(8):603-10 [21669460] Eur J Immunol. 2012 Jun;42(6):1573-84 [22678910] Proteins. 2013 Jan;81(1):119-31 [22927229] PLoS One. 2013;8(2):e57491 [23469002] PLoS One. 2013;8(8):e72772 [23936544] Mucosal Immunol. 2014 Mar;7(2):348-58 [23945545] J Cell Biol. 2014 May 12;205(3):409-28 [24821840] Sci Transl Med. 2014 May 21;6(237):237ra65 [24848255] J Reprod Immunol. 2014 Dec;106:89-99 [24933117] J Cell Sci. 2003 Jan 15;116(Pt 2):217-24 [12482908] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1074/jbc.M114.597518 ER - TY - JOUR T1 - Modifying welding process parameters can reduce the neurotoxic potential of manganese-containing welding fumes. AN - 1652422483; 25549921 AB - Welding fumes (WF) are a complex mixture of toxic metals and gases, inhalation of which can lead to adverse health effects among welders. The presence of manganese (Mn) in welding electrodes is cause for concern about the potential development of Parkinson's disease (PD)-like neurological disorder. Consequently, from an occupational safety perspective, there is a critical need to prevent adverse exposures to WF. As the fume generation rate and physicochemical characteristics of welding aerosols are influenced by welding process parameters like voltage, current or shielding gas, we sought to determine if changing such parameters can alter the fume profile and consequently its neurotoxic potential. Specifically, we evaluated the influence of voltage on fume composition and neurotoxic outcome. Rats were exposed by whole-body inhalation (40 mg/m(3); 3h/day × 5 d/week × 2 weeks) to fumes generated by gas-metal arc welding using stainless steel electrodes (GMA-SS) at standard/regular voltage (25 V; RVSS) or high voltage (30 V; HVSS). Fumes generated under these conditions exhibited similar particulate morphology, appearing as chain-like aggregates; however, HVSS fumes comprised of a larger fraction of ultrafine particulates that are generally considered to be more toxic than their fine counterparts. Paradoxically, exposure to HVSS fumes did not elicit dopaminergic neurotoxicity, as monitored by the expression of dopaminergic and PD-related markers. We show that the lack of neurotoxicity is due to reduced solubility of Mn in HVSS fumes. Our findings show promise for process control procedures in developing prevention strategies for Mn-related neurotoxicity during welding; however, it warrants additional investigations to determine if such modifications can be suitably adapted at the workplace to avert or reduce adverse neurological risks. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Sriram, Krishnan AU - Lin, Gary X AU - Jefferson, Amy M AU - Stone, Samuel AU - Afshari, Aliakbar AU - Keane, Michael J AU - McKinney, Walter AU - Jackson, Mark AU - Chen, Bean T AU - Schwegler-Berry, Diane AU - Cumpston, Amy AU - Cumpston, Jared L AU - Roberts, Jenny R AU - Frazer, David G AU - Antonini, James M AD - Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Electronic address: kos4@cdc.gov. ; Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2015/02/03/ PY - 2015 DA - 2015 Feb 03 SP - 168 EP - 178 VL - 328 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Manganese KW - 42Z2K6ZL8P KW - Index Medicus KW - Parkinson’s disease KW - Prevention KW - Parkinsonism KW - Neurotoxicity KW - Welding KW - Animals KW - Solubility KW - Dopaminergic Neurons -- drug effects KW - Body Burden KW - Humans KW - Particle Size KW - Dopaminergic Neurons -- metabolism KW - Risk Assessment KW - Equipment Design KW - Rats, Sprague-Dawley KW - Gene Expression Regulation -- drug effects KW - Time Factors KW - Male KW - Welding -- methods KW - Brain -- drug effects KW - Brain -- metabolism KW - Air Pollutants, Occupational -- toxicity KW - Welding -- instrumentation KW - Air Pollutants, Occupational -- chemistry KW - Manganese Poisoning -- genetics KW - Manganese Poisoning -- metabolism KW - Parkinson Disease, Secondary -- metabolism KW - Inhalation Exposure -- prevention & control KW - Manganese Poisoning -- prevention & control KW - Manganese -- chemistry KW - Parkinson Disease, Secondary -- prevention & control KW - Manganese Poisoning -- etiology KW - Parkinson Disease, Secondary -- genetics KW - Parkinson Disease, Secondary -- etiology KW - Inhalation Exposure -- adverse effects KW - Manganese -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652422483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Modifying+welding+process+parameters+can+reduce+the+neurotoxic+potential+of+manganese-containing+welding+fumes.&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BStone%2C+Samuel%3BAfshari%2C+Aliakbar%3BKeane%2C+Michael+J%3BMcKinney%2C+Walter%3BJackson%2C+Mark%3BChen%2C+Bean+T%3BSchwegler-Berry%2C+Diane%3BCumpston%2C+Amy%3BCumpston%2C+Jared+L%3BRoberts%2C+Jenny+R%3BFrazer%2C+David+G%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2015-02-03&rft.volume=328&rft.issue=&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2014.12.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-25 N1 - Date created - 2015-01-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neurology. 2001 Jan 9;56(1):8-13 [11148228] N Engl J Med. 2000 May 25;342(21):1560-7 [10824074] Ann Occup Hyg. 2001 Apr;45(3):187-92 [11295141] FASEB J. 2002 Sep;16(11):1474-6 [12205053] J Toxicol Environ Health A. 2002 Oct 25;65(20):1531-43 [12396867] Science. 2003 Jan 10;299(5604):256-9 [12446870] Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8 [12666096] Brain. 2003 Jun;126(Pt 6):1271-8 [12764050] Ann Neurol. 2004 Jan;55(1):113-8 [14705119] Parkinsonism Relat Disord. 2004 May;10 Suppl 1:S3-7 [15109580] Ind Health. 2004 Apr;42(2):111-5 [15128159] Acta Neuropathol. 2004 Jun;107(6):489-96 [14991385] Inhal Toxicol. 2004 Jun;16(6-7):437-45 [15204759] Occup Environ Med. 2007 Mar;64(3):167-77 [17018581] Neurotoxicology. 2007 Mar;28(2):298-311 [17169432] PLoS One. 2007;2(9):e843 [17786214] J Occup Environ Hyg. 2007 Dec;4(12):903-12 [17957560] Neurosci Lett. 2010 Apr 5;473(2):146-50 [20178828] Arch Toxicol. 2010 Jul;84(7):521-40 [20224926] FASEB J. 2010 Dec;24(12):4989-5002 [20798247] J Environ Monit. 2010 May;12(5):1133-40 [21491680] Nanotoxicology. 2011 Dec;5(4):700-10 [21281223] Biochim Biophys Acta. 1976 Aug 24;444(1):1-10 [60137] Ann Occup Hyg. 1982;25(4):431-8 [7165223] Am J Respir Cell Mol Biol. 1992 Feb;6(2):235-43 [1540387] Br J Ind Med. 1993 Jun;50(6):510-3 [8329316] Trends Neurosci. 1996 Aug;19(8):312-8 [8843599] Ann ICRP. 1994;24(1-3):1-482 [7726471] Neurosci Lett. 1994 Jan 3;165(1-2):208-10 [8015728] Brain Res. 1997 Feb 21;749(1):44-52 [9070626] Nature. 1997 Jul 31;388(6641):482-8 [9242408] Nature. 1998 Apr 9;392(6676):605-8 [9560156] Hum Mol Genet. 1999 Apr;8(4):567-74 [10072423] Prog Neurobiol. 1999 Apr;57(6):563-81 [10221782] Mol Med Today. 1999 May;5(5):225-32 [10322315] Am J Respir Crit Care Med. 1999 Jun;159(6):1943-8 [10351943] Neurology. 2005 Jan 25;64(2):230-5 [15668418] Neurology. 2005 Jun 28;64(12):2033-9 [15888601] J Neurochem. 2006 Feb;96(3):706-18 [16405514] J Occup Environ Hyg. 2006 Apr;3(4):194-203; quiz D45 [16531292] FASEB J. 2006 Apr;20(6):670-82 [16581975] Neurotoxicology. 2006 May;27(3):315-26 [16343629] Environ Health Perspect. 2006 Aug;114(8):1172-8 [16882521] Neurotoxicology. 1999 Dec;20(6):901-7 [10693971] Toxicol Appl Pharmacol. 2001 Jan 15;170(2):79-87 [11162771] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2014.12.015 ER - TY - JOUR T1 - Multi-walled carbon nanotube-induced gene expression in vitro: concordance with in vivo studies. AN - 1652417462; 25511174 AB - There is a current interest in reducing the in vivo toxicity testing of nanomaterials in animals by increasing toxicity testing using in vitro cellular assays; however, toxicological results are seldom concordant between in vivo and in vitro models. This study compared global multi-walled carbon nanotube (MWCNT)-induced gene expression from human lung epithelial and microvascular endothelial cells in monoculture and coculture with gene expression from mouse lungs exposed to MWCNT. Using a cutoff of 10% false discovery rate and 1.5 fold change, we determined that there were more concordant genes (gene expression both up- or downregulated in vivo and in vitro) expressed in both cell types in coculture than in monoculture. When reduced to only those genes involved in inflammation and fibrosis, known outcomes of in vivo MWCNT exposure, there were more disease-related concordant genes expressed in coculture than monoculture. Additionally, different cellular signaling pathways are activated in response to MWCNT dependent upon culturing conditions. As coculture gene expression better correlated with in vivo gene expression, we suggest that cellular cocultures may offer enhanced in vitro models for nanoparticle risk assessment and the reduction of in vivo toxicological testing. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology AU - Snyder-Talkington, Brandi N AU - Dong, Chunlin AU - Zhao, Xiangyi AU - Dymacek, Julian AU - Porter, Dale W AU - Wolfarth, Michael G AU - Castranova, Vincent AU - Qian, Yong AU - Guo, Nancy L AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. ; Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300, USA. ; Lane Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, WV 26506-6070, USA. ; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA. ; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Electronic address: yaq2@cdc.gov. ; Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300, USA. Electronic address: lguo@hsc.wvu.edu. Y1 - 2015/02/03/ PY - 2015 DA - 2015 Feb 03 SP - 66 EP - 74 VL - 328 KW - Genetic Markers KW - 0 KW - Nanotubes, Carbon KW - RNA, Messenger KW - Index Medicus KW - Gene expression KW - In vivo KW - Correlation KW - Coculture KW - In vitro KW - Animals KW - Coculture Techniques KW - Reproducibility of Results KW - Oligonucleotide Array Sequence Analysis KW - Gene Regulatory Networks -- drug effects KW - Humans KW - Gene Expression Profiling -- methods KW - Risk Assessment KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Gene Expression Regulation -- drug effects KW - Male KW - Inhalation Exposure -- adverse effects KW - Lung -- blood supply KW - Epithelial Cells -- metabolism KW - Endothelial Cells -- drug effects KW - Epithelial Cells -- drug effects KW - Lung -- drug effects KW - Lung -- metabolism KW - Nanotubes, Carbon -- toxicity KW - Endothelial Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652417462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Airborne+manganese+as+dust+vs.+fume+determining+blood+levels+in+workers+at+a+manganese+alloy+production+plant&rft.au=Park%2C+Robert+M%3BBaldwin%2C+Mary%3BBouchard%2C+Maryse+F%3BMergler%2C+Donna&rft.aulast=Park&rft.aufirst=Robert&rft.date=2014-12-01&rft.volume=45&rft.issue=&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2014.03.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-25 N1 - Date created - 2015-01-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Part Fibre Toxicol. 2013;10:33 [23895460] ALTEX. 2014;31(4):441-77 [25027500] Environ Health Perspect. 2004 Mar;112(4):420-2 [15033590] Lab Invest. 2004 Jun;84(6):736-52 [15077120] Biochem Biophys Res Commun. 2004 Sep 3;321(4):788-94 [15358096] J Cell Sci. 1998 Mar;111 ( Pt 5):541-7 [9454728] Am J Physiol. 1998 May;274(5 Pt 1):L810-9 [9612297] J Cell Sci. 1999 Jan;112 ( Pt 2):243-52 [9858477] Mol Carcinog. 1999 Mar;24(3):153-9 [10204799] Environ Health Perspect. 2004 Dec;112(17):1679-86 [15579413] Biostatistics. 2005 Jan;6(1):27-38 [15618525] J Appl Toxicol. 2014 May;34(5):506-15 [23765558] J Toxicol Environ Health A. 2012;75(18):1129-53 [22891886] J Toxicol Environ Health B Crit Rev. 2012;15(7):468-92 [23190270] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21 [11309499] Respir Res. 2001;2(1):33-46 [11686863] Science. 2013 Feb 1;339(6119):535-9 [23372006] Biomed Res Int. 2013;2013:734137 [23509768] Toxicol Sci. 2013 May;133(1):79-89 [23377615] Part Fibre Toxicol. 2013;10:35 [23903001] Nanotoxicology. 2013 Nov;7(7):1179-94 [22881873] PLoS One. 2013;8(11):e80452 [24260392] Nanotoxicology. 2014 Aug;8(5):533-48 [23659652] Toxicol Sci. 2014 Jan;137(1):55-64 [24284789] Part Fibre Toxicol. 2014;11:3 [24405760] Analyst. 2014 Mar 7;139(5):882-95 [24343342] Part Fibre Toxicol. 2014;11:6 [24479647] Carcinogenesis. 2005 Apr;26(4):725-31 [15677631] Pharmacogenomics. 2005 Jun;6(4):419-28 [16004560] Exp Toxicol Pathol. 2005 Jul;57 Suppl 1:233-8 [16092731] Hum Cell. 2006 May;19(2):65-70 [16879558] Toxicol Sci. 2007 May;97(1):163-80 [17301066] Nano Lett. 2007 Aug;7(8):2399-406 [17630811] Bioinformatics. 2007 Aug 15;23(16):2180-2 [17545180] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18211-6 [17984051] BMC Genomics. 2008;9:169 [18410680] ALTEX. 2008;25(2):91-102 [18551232] Inhal Toxicol. 2008 Jun;20(8):741-9 [18569096] Altern Lab Anim. 2008 Jul;36(3):285-98 [18662093] Expert Opin Drug Metab Toxicol. 2008 Aug;4(8):1075-89 [18680442] Eur Respir J. 2008 Nov;32(5):1184-94 [18653652] Pharmacol Ther. 2009 Feb;121(2):192-204 [19103221] Cell Tissue Res. 2009 Apr;336(1):91-105 [19238447] Toxicol Appl Pharmacol. 2010 Jan 1;242(1):56-65 [19796648] J R Soc Interface. 2010 Feb 6;7 Suppl 1:S27-40 [19586954] BMC Bioinformatics. 2010;11:10 [20053291] J Toxicol Environ Health A. 2010;73(5):378-95 [20155580] Toxicology. 2010 Mar 10;269(2-3):136-47 [19857541] Nat Biotechnol. 2010 Aug;28(8):827-38 [20676074] Nanotoxicology. 2010 Jun;4(2):207-46 [20795897] Crit Rev Toxicol. 2010 Oct;40(9):759-90 [20860524] Part Fibre Toxicol. 2011;8(1):6 [21272353] Toxicol Sci. 2011 Mar;120 Suppl 1:S225-37 [21177775] J Occup Environ Med. 2011 Jun;53(6 Suppl):S14-7 [21606847] Toxicol Appl Pharmacol. 2011 Aug 15;255(1):18-31 [21624382] Part Fibre Toxicol. 2011;8:21 [21781304] Database (Oxford). 2011;2011:bar049 [22083790] Toxicol In Vitro. 2011 Dec;25(8):1516-34 [21963807] J Toxicol Environ Health A. 2012;75(2):112-28 [22129238] PLoS Comput Biol. 2012;8(5):e1002514 [22615551] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2014.12.012 ER - TY - JOUR T1 - Methods of dark signal determination for CCD array spectroradiometers used in solar UVR measurements AN - 1827887908; PQ0003669170 AB - The methods of the dark signal determination by direct contemporaneous measurements using a light spectrum and modelling of the dark signal based on the dark signal characterisation data were discussed. These techniques were tested with two charge-couple detectors (CCD) array spectroradiometers used in solar UVR measurements. The sensitivity of both instruments was significantly reduced when shutters were used; the measured signal varied by up to 12% depending on the orientation of the shutter. The shutters should be permanently attached to the SSR, so that the orientation cannot be changed to prevent an increase in uncertainty. The method of using blind pixels from the optically inactive part of the CCD array in a light spectrum could be used to derive the dark signal with some limitations for integration times <10 s for the QE65000. An alternative method of deriving the dark signal from light measurements using out-of-range pixels has been proved impossible due to out-of-range stray light in both instruments. The dark signal was characterised for the range of integration times and ambient temperatures of 15-35[degrees]C. Based on these data, the model of the dark signal was developed so that a single value of the dark signal can be subtracted over the whole spectral range if the instrument temperature is known. JF - Radiation Protection Dosimetry AU - Baczynska, K A AU - Khazova, M AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire OX11 0RQ, UK, katarzyna.baczynska@phe.gov.uk Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 387 EP - 393 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 163 IS - 3 SN - 0144-8420, 0144-8420 KW - Environment Abstracts KW - Sensitivity KW - Radiation KW - Dosimetry KW - Temperature KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827887908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Methods+of+dark+signal+determination+for+CCD+array+spectroradiometers+used+in+solar+UVR+measurements&rft.au=Baczynska%2C+K+A%3BKhazova%2C+M&rft.aulast=Baczynska&rft.aufirst=K&rft.date=2015-02-01&rft.volume=163&rft.issue=3&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncu191 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Sensitivity; Radiation; Dosimetry; Temperature DO - http://dx.doi.org/10.1093/rpd/ncu191 ER - TY - RPRT T1 - Family Strengthening Research: FY2014. OPRE Report 2015-22 AN - 1773221794; ED558538 AB - This report provides detailed summaries of major research investments by OPRE's Division of Family Strengthening (DFS) along with brief overviews of past projects. The featured projects cover topics that include strengthening relationships within families, supporting fatherhood, nurturing children through their families, reducing teen pregnancy, supporting youth in their transition to adulthood, and preventing family violence. The report also describes DFS's investments in activities to disseminate rigorous research on family strengthening topics to a diverse range of stakeholders including federal and state policy-makers, program administrators, researchers, and intermediary organizations. This report covers OPRE-funded projects through Fiscal Year 2014. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 25 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Parenthood KW - Home Visits KW - Research Projects KW - Family Relationship KW - Youth Programs KW - Fathers KW - American Indians KW - Prevention KW - Child Rearing KW - Parent Child Relationship KW - Family Violence KW - Investment KW - Alaska Natives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773221794?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - Toddlers in Early Head Start: A Portrait of 2-Year-Olds, Their Families, and the Programs Serving Them. Volume 1: Age 2 Report. OPRE Report 2015-10 AN - 1773221697; ED558558 AB - The Early Head Start Family and Child Experiences Survey (Baby FACES) is a descriptive study of Early Head Start programs designed to inform policy and practice at both national and local levels. Baby FACES follows two cohorts of children through their time in Early Head Start, starting in 2009, the first wave of data collection. The Newborn Cohort includes 194 pregnant mothers and newborn children; and the-1-year-old Cohort includes 782 children who were approximately 1 year old (ranging from 10 to 15 months) at the outset of the study. This Baby FACES report focuses on the second wave of data collection and the children from the 1-year-old Cohort (who were 2 in 2010), and presents findings on two broad topics: (1) Describing Early Head Start program services and staff qualifications; and (2) Describing child and family outcomes at age 2. This report sets the stage for a final report on 3-year-olds to follow. The next report will include information collected in spring 2011 and 2012, and will include all study children who remain in the program through age 3. The final report on 3-year-olds will focus on understanding and modeling the longitudinal aspects of the data to offer insight into relations among family/child and staff characteristics, service uptake, service quality, program characteristics, and outcomes. [See earlier report, "Head Start Children, Families, and Programs: Present and Past Data from FACES. OPRE Report 2011-33a," at ED539261.] AU - Vogel, Cheri A. AU - Caronongan, Pia AU - Thomas, Jaime AU - Bandel, Eileen AU - Xue, Yange AU - Henke, Juliette AU - Aikens, Nikki AU - Boller, Kimberly AU - Murphy, Lauren Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 164 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Preschool Education KW - Early Childhood Education KW - Program Effectiveness KW - Toddlers KW - Language Acquisition KW - Child Caregivers KW - Teacher Attitudes KW - Family Relationship KW - Child Care KW - Outcomes of Education KW - Child Development KW - Disadvantaged Youth KW - Social Development KW - Access to Health Care KW - Preschool Children KW - Teacher Qualifications KW - Program Descriptions KW - Measures (Individuals) KW - Parent Teacher Cooperation KW - Language Skills KW - Teacher Characteristics KW - Mothers KW - Longitudinal Studies KW - Emotional Development KW - Pregnancy KW - Risk KW - Educational Policy KW - Parent Attitudes KW - Educational Quality KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773221697?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Characterizing titanium dioxide and zinc oxide nanoparticles in sunscreen spray AN - 1751203541; PQ0002282987 AB - Synopsis Objective Numerous commercial products contain titanium dioxide (TiO sub(2)) and zinc oxide (ZnO) nanoparticles (NPs); however, many of these are not labelled as containing NPs. This study sought to develop an effective means of characterizing TiO sub(2) and ZnO NPs in sunscreen sprays, including the size, shape and composition of the particles as well as their aggregation/agglomeration characteristics. Methods Transmission electron microscopy (TEM) coupled with a window-type microchip K-kit/copper grid and X-ray diffraction (XRD) was used to characterize the oxide NPs. Results TME pre-treatment was performed using two approaches: using a conventional copper grid (requiring dilution) and using a K-kit (not requiring dilution). The use of K-kit in conjunction with XRD makes it possible to obtain direct measurements from samples that have not undergone pre-treatment, which could otherwise alter the nature of the samples, such as the degree of agglomeration. XRD was used to obtain information related to particle size and crystal structure. A strong correlation was observed between XRD and TEM measurements. Conclusion The proposed measurement methods were shown to be highly effective in the characterization of oxide NPs in sunscreen sprays, providing consistent information related to NPs and their interactions in the formulations.Original Abstract: Resume Objectif De nombreux produits commerciaux contiennent des nanoparticules (NP) du dioxyde de titane (TiO2) et de l'oxyde de zinc (ZnO). Toutefois, beaucoup de ces produits ne sont pas etiquetes comme contenant des NP. Cette etude a cherche a developper un moyen efficace de caracteriser les NP de TiO2 et ZnO dans les aerosols de protection solaire, y compris la taille, la forme et la composition des particules ainsi que leurs caracteristiques d'agregation/agglomeration. Methodes La microscopie electronique a transmission (MET) couplee avec une grille cuivre de type a fenetre micropuce K-kit et la diffraction des rayons X (XRD) ont ete utilisees pour caracteriser les NP d'oxyde. Resultats Le pre-traitement TME a ete effectuee en utilisant deux approches: l'utilisation d'une grille de cuivre conventionnel (necessitant une dilution) et en utilisant une K-kit (ne necessitant pas de dilution). L'utilisation de K-kit conjointement avec diffraction des rayons X permet d'obtenir des mesures directes a partir d'echantillons qui n'ont pas subi un pretraitement qui, sinon, pourrait modifier la nature des echantillons, tels que le degre d'agglomeration. DRX a ete utilise pour obtenir des informations relatives a la taille des particules et la structure cristalline. Une forte correlation a ete observee entre les mesures XRD et TEM. Conclusion Les methodes de mesure proposees ont ete presentees pour etre tres efficace dans la caracterisation des NP d'oxyde dans les sprays de protection solaire, et de fournir des informations coherentes liees aux NP et leurs interactions dans les formulations. JF - International Journal of Cosmetic Science AU - Lu, P J AU - Cheng, W L AU - Huang, S C AU - Chen, Y P AU - Chou, H K AU - Cheng, H F AD - Food and Drug Administration, Ministry of Health and Welfare, No.161-2, Kunyang St, Nangang District, Taipei City, 115-61, Taiwan. PY - 2015 SP - 620 EP - 626 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 37 IS - 6 SN - 0142-5463, 0142-5463 KW - Toxicology Abstracts KW - Transmission electron microscopy KW - Cosmetics KW - Copper KW - X-ray diffraction KW - zinc oxide KW - Titanium dioxide KW - microchips KW - Crystal structure KW - Sunscreens KW - oxides KW - nanoparticles KW - Agglomeration KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751203541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cosmetic+Science&rft.atitle=Characterizing+titanium+dioxide+and+zinc+oxide+nanoparticles+in+sunscreen+spray&rft.au=Lu%2C+P+J%3BCheng%2C+W+L%3BHuang%2C+S+C%3BChen%2C+Y+P%3BChou%2C+H+K%3BCheng%2C+H+F&rft.aulast=Lu&rft.aufirst=P&rft.date=2015-02-01&rft.volume=37&rft.issue=6&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cosmetic+Science&rft.issn=01425463&rft_id=info:doi/10.1111%2Fics.12239 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Titanium dioxide; zinc oxide; Transmission electron microscopy; microchips; Crystal structure; oxides; Sunscreens; Cosmetics; Copper; X-ray diffraction; nanoparticles; Agglomeration DO - http://dx.doi.org/10.1111/ics.12239 ER - TY - JOUR T1 - Migration Patterns and Characteristics of Sexual Partners Associated with Unprotected Sexual Intercourse Among Hispanic Immigrant and Migrant Women in the United States AN - 1746892144; PQ0002271899 AB - In 2011, Hispanic immigrant women comprised 44 % of HIV diagnoses among Hispanic women in the United States but little is known about factors that may place these women at risk for infection with HIV or sexually transmitted diseases. From March 2005 to February 2007, women were recruited at community-based organizations offering services to immigrant and migrant communities in five U.S. states. We report factors independently associated with unprotected anal and vaginal sex in the past 12 months among Hispanic immigrant and migrant women. Greater work-related mobility was associated with unprotected anal sex, while recency of immigration and prior refusal of HIV testing were associated with women's reports of unprotected vaginal sex. Prior sex with an injection drug user was associated with reports of both unprotected anal and vaginal sex. Findings highlight the need for HIV/STD risk reduction interventions designed specifically for Hispanic immigrant and migrant women. JF - Journal of Immigrant and Minority Health AU - Valverde, Eduardo E AU - Painter, Thomas AU - Heffelfinger, James D AU - Schulden, Jeffrey D AU - Chavez, Pollyanna AU - DiNenno, Elizabeth A AD - Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, USA, Evalverde@cdc.gov PY - 2015 SP - 1826 EP - 1833 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 6 SN - 1557-1912, 1557-1912 KW - Risk Abstracts KW - Mobility KW - Immigrants KW - Intervention KW - Risk reduction KW - Anal sex KW - Drug abuse KW - Infection KW - Sexual behavior KW - USA KW - Human immunodeficiency virus KW - Risk factors KW - Females KW - Sexually transmitted diseases KW - Migrants KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746892144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Migration+Patterns+and+Characteristics+of+Sexual+Partners+Associated+with+Unprotected+Sexual+Intercourse+Among+Hispanic+Immigrant+and+Migrant+Women+in+the+United+States&rft.au=Valverde%2C+Eduardo+E%3BPainter%2C+Thomas%3BHeffelfinger%2C+James+D%3BSchulden%2C+Jeffrey+D%3BChavez%2C+Pollyanna%3BDiNenno%2C+Elizabeth+A&rft.aulast=Valverde&rft.aufirst=Eduardo&rft.date=2015-02-01&rft.volume=17&rft.issue=6&rft.spage=1826&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-014-0132-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 35 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Mobility; Immigrants; Intervention; Anal sex; Risk reduction; Infection; Drug abuse; Sexual behavior; Human immunodeficiency virus; Risk factors; Females; Ethnic groups; Migrants; Sexually transmitted diseases; USA DO - http://dx.doi.org/10.1007/s10903-014-0132-6 ER - TY - JOUR T1 - Educational attainment and life expectancy: A perspective from the NIH Office of Behavioral and Social Sciences Research AN - 1738477075; 201539221 AB - The NIH Office of Behavioral and Social Sciences Research (OBSSR) furthers the mission of the NIH by stimulating behavioral and social sciences research throughout NIH and integrating these areas of research more fully into the NIH health research enterprise, thereby improving our understanding, treatment, and prevention of disease. OBSSR accomplishes this mission through several strategic priorities: (1) supporting the next generation of basic behavioral and social sciences research, (2) facilitating interdisciplinary research, (3) promoting a multi-level systems perspective of health and behavior, and (4) encouraging a problem-focused perspective on population health. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - Spittel, Michael L AU - Riley, William T AU - Kaplan, Robert M AD - Office of Behavioral and Social Sciences Research (OBSSR/NIH), US Department of Health and Human Services, USA Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 203 EP - 205 PB - Elsevier Science, Amsterdam The Netherlands VL - 127 SN - 0277-9536, 0277-9536 KW - NIH BSSR Education and health Program KW - Prevention KW - Health Research KW - Social Science Research KW - Health Behavior KW - Interdisciplinary Approach KW - Educational Attainment KW - Diseases KW - Longevity KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738477075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Educational+attainment+and+life+expectancy%3A+A+perspective+from+the+NIH+Office+of+Behavioral+and+Social+Sciences+Research&rft.au=Spittel%2C+Michael+L%3BRiley%2C+William+T%3BKaplan%2C+Robert+M&rft.aulast=Spittel&rft.aufirst=Michael&rft.date=2015-02-01&rft.volume=127&rft.issue=&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2014.11.017 LA - English DB - Sociological Abstracts N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Social Science Research; Health Behavior; Diseases; Longevity; Health Research; Educational Attainment; Interdisciplinary Approach; Prevention DO - http://dx.doi.org/10.1016/j.socscimed.2014.11.017 ER - TY - JOUR T1 - NIOSH national survey of long-haul truck drivers: Injury and safety AN - 1735923372; PQ0002291592 AB - Approximately 1,701,500 people were employed as heavy and tractor-trailer truck drivers in the United States in 2012. The majority of them were long-haul truck drivers (LHTDs). There are limited data on occupational injury and safety in LHTDs, which prompted a targeted national survey. The National Institute of Occupational Safety and Health conducted a nationally representative survey of 1265 LHTDs at 32 truck stops across the contiguous United States in 2010. Data were collected on truck crashes, near misses, moving violations, work-related injuries, work environment, safety climate, driver training, job satisfaction, and driving behaviors. Results suggested that an estimated 2.6% of LHTDs reported a truck crash in 2010, 35% reported at least one crash while working as an LHTD, 24% reported at least one near miss in the previous 7 days, 17% reported at least one moving violation ticket and 4.7% reported a non-crash injury involving days away from work in the previous 12 months. The majority (68%) of non-crash injuries among company drivers were not reported to employers. An estimate of 73% of LHTDs (16% often and 58% sometimes) perceived their delivery schedules unrealistically tight; 24% often continued driving despite fatigue, bad weather, or heavy traffic because they needed to deliver or pick up a load at a given time; 4.5% often drove 10miles per hours or more over the speed limit; 6.0% never wore a seatbelt; 36% were often frustrated by other drivers on the road; 35% often had to wait for access to a loading dock; 37% reported being noncompliant with hours-of-service rules (10% often and 27% sometimes); 38% of LHTDs perceived their entry-level training inadequate; and 15% did not feel that safety of workers was a high priority with their management. This survey brings to light a number of important safety issues for further research and interventions, e.g., high prevalence of truck crashes, injury underreporting, unrealistically tight delivery schedules, noncompliance with hours-of-service rules, and inadequate entry-level training. JF - Accident Analysis & Prevention AU - Chen, Guang X AU - Sieber, WKarl AU - Lincoln, Jennifer E AU - Birdsey, Jan AU - Hitchcock, Edward M AU - Nakata, Akinori AU - Robinson, Cynthia F AU - Collins, James W AU - Sweeney, Marie H AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV, United States PY - 2015 SP - 66 EP - 72 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 85 SN - 0001-4575, 0001-4575 KW - Health & Safety Science Abstracts KW - Long-haul truck drivers KW - Truck driver safety KW - Truck driver injury KW - Risk factor KW - Survey KW - Hours of service KW - Weather KW - Injuries KW - Training KW - Motor vehicles KW - Occupational safety KW - Safety KW - Intervention KW - Traffic KW - USA KW - Accidents KW - Traffic management KW - Driving ability KW - Perception KW - Trucks KW - Traffic safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735923372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accident+Analysis+%26+Prevention&rft.atitle=NIOSH+national+survey+of+long-haul+truck+drivers%3A+Injury+and+safety&rft.au=Chen%2C+Guang+X%3BSieber%2C+WKarl%3BLincoln%2C+Jennifer+E%3BBirdsey%2C+Jan%3BHitchcock%2C+Edward+M%3BNakata%2C+Akinori%3BRobinson%2C+Cynthia+F%3BCollins%2C+James+W%3BSweeney%2C+Marie+H&rft.aulast=Chen&rft.aufirst=Guang&rft.date=2015-02-01&rft.volume=85&rft.issue=&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Accident+Analysis+%26+Prevention&rft.issn=00014575&rft_id=info:doi/10.1016%2Fj.aap.2015.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Weather; Injuries; Training; Motor vehicles; Safety; Occupational safety; Intervention; Traffic; Accidents; Driving ability; Traffic management; Perception; Trucks; Traffic safety; USA DO - http://dx.doi.org/10.1016/j.aap.2015.09.001 ER - TY - JOUR T1 - Live Attenuated and Inactivated Influenza Vaccines in Children AN - 1687673913; PQ0001568798 AB - Background. Live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV) are available for children. Local and systemic immunity induced by LAIV followed a month later by LAIV and IIV followed by LAIV were investigated with virus recovery after LAIV doses as surrogates for protection against influenza on natural exposure. Methods. Fifteen children received IIV followed by LAIV, 13 an initial dose of LAIV, and 11 a second dose of LAIV. The studies were done during autumn 2009 and autumn 2010 with the same seasonal vaccine (A/California/07/09 [H1N1], A/Perth/16/09 [H3N2], B/Brisbane/60/08). Results. Twenty-eight of 39 possible influenza viral strains were recovered after the initial dose of LAIV. When LAIV followed IIV, 21 of 45 viral strains were identified. When compared to primary LAIV infection, the decreased frequency of shedding with the IIV-LAIV schedule was significant (P = .023). With LAIV-LAIV, the fewest viral strains were recovered (3/33)-numbers significantly lower (P < .001) than shedding after initial LAIV and after IIV-LAIV (P < .001). Serum hemagglutination inhibition antibody responses were more frequent after IIV than LAIV (P = .02). In contrast, more mucosal immunoglobulin A responses were seen with LAIV. Conclusions. LAIV priming induces greater inhibition of virus recovery on LAIV challenge than IIV priming. The correlate(s) of protection are the subject of ongoing analysis. JF - Journal of Infectious Diseases AU - Ilyushina, Natalia A AU - Haynes, Brenda C AU - Hoen, Anne G AU - Khalenkov, Alexey M AU - Housman, Molly L AU - Brown, Eric P AU - Ackerman, Margaret E AU - Treanor, John J AU - Luke, Catherine J AU - Subbarao, Kanta AU - Wright, Peter F AD - Department of Pediatrics; Food and Drug Administration Center for Drug Evaluation and Research, Bethesda, Maryland, peter.f.wright@hitchcock.org Y1 - 2015/02/01/ PY - 2015 DA - 2015 Feb 01 SP - 352 EP - 360 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 211 IS - 3 SN - 0022-1899, 0022-1899 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - influenza KW - vaccines KW - children KW - Hemagglutination inhibition KW - Mucosa KW - Immunity KW - Children KW - Infection KW - Influenza KW - Immunoglobulin A KW - Sulfur dioxide KW - Infectious diseases KW - INE, USA, California KW - Australia, Western Australia, Perth KW - Vaccines KW - Seasonal variations KW - Australia, Queensland, Brisbane KW - F 06910:Microorganisms & Parasites KW - H 4000:Food and Drugs KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687673913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Live+Attenuated+and+Inactivated+Influenza+Vaccines+in+Children&rft.au=Ilyushina%2C+Natalia+A%3BHaynes%2C+Brenda+C%3BHoen%2C+Anne+G%3BKhalenkov%2C+Alexey+M%3BHousman%2C+Molly+L%3BBrown%2C+Eric+P%3BAckerman%2C+Margaret+E%3BTreanor%2C+John+J%3BLuke%2C+Catherine+J%3BSubbarao%2C+Kanta%3BWright%2C+Peter+F&rft.aulast=Ilyushina&rft.aufirst=Natalia&rft.date=2015-02-01&rft.volume=211&rft.issue=3&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu458 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Influenza; Immunoglobulin A; Hemagglutination inhibition; Mucosa; Immunity; Vaccines; Infection; Children; Sulfur dioxide; Infectious diseases; Seasonal variations; INE, USA, California; Australia, Western Australia, Perth; Australia, Queensland, Brisbane DO - http://dx.doi.org/10.1093/infdis/jiu458 ER - TY - JOUR T1 - APPLICATION OF AN INFORMATICS-BASED DECISION-MAKING FRAMEWORK AND PROCESS TO THE ASSESSMENT OF RADIATION SAFETY IN NANOTECHNOLOGY AN - 1676360621; PQ0001237868 AB - The National Council on Radiation Protection and Measurements (NCRP) established NCRP Scientific Committee 2-6 to develop a report on the current state of knowledge and guidance for radiation safety programs involved with nanotechnology. Nanotechnology is the understanding and control of matter at the nanoscale, at dimensions between ~1 and 100 nm, where unique phenomena enable novel applications. While the full report is in preparation, this paper presents and applies an informatics-based decision-making framework and process through which the radiation protection community can anticipate that nano-enabled applications, processes, nanomaterials, and nanoparticles are likely to become present or are already present in radiation-related activities; recognize specific situations where environmental and worker safety, health, well-being, and productivity may be affected by nano-related activities; evaluate how radiation protection practices may need to be altered to improve protection; control information, interpretations, assumptions, and conclusions to implement scientifically sound decisions and actions; and confirm that desired protection outcomes have been achieved. This generally applicable framework and supporting process can be continuously applied to achieve health and safety at the convergence of nanotechnology and radiation-related activities. JF - Health Physics AU - Hoover, Mark D AU - Myers, David S AU - Cash, Leigh J AU - Guilmette, Raymond A AU - Kreyling, Wolfgang G AU - Oberdorster, Gunter AU - Smith, Rachel AU - Cassata, James R AU - Boecker, Bruce B AU - Grissom, Michael P AD - National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, mhoover1@cdc.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 179 EP - 194 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 108 IS - 2 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts KW - National Council on Radiation Protection and Measurements KW - occupational safety KW - radiation protection KW - risk analysis KW - Radiation KW - Committees KW - Safety KW - Occupational safety KW - Councils KW - Nanotechnology KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676360621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=APPLICATION+OF+AN+INFORMATICS-BASED+DECISION-MAKING+FRAMEWORK+AND+PROCESS+TO+THE+ASSESSMENT+OF+RADIATION+SAFETY+IN+NANOTECHNOLOGY&rft.au=Hoover%2C+Mark+D%3BMyers%2C+David+S%3BCash%2C+Leigh+J%3BGuilmette%2C+Raymond+A%3BKreyling%2C+Wolfgang+G%3BOberdorster%2C+Gunter%3BSmith%2C+Rachel%3BCassata%2C+James+R%3BBoecker%2C+Bruce+B%3BGrissom%2C+Michael+P&rft.aulast=Hoover&rft.aufirst=Mark&rft.date=2015-02-01&rft.volume=108&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0000000000000250 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Radiation; Committees; Occupational safety; Safety; Councils; Nanotechnology DO - http://dx.doi.org/10.1097/HP.0000000000000250 ER - TY - JOUR T1 - Adoption of the Good Behaviour Game: An evidence-based intervention for the prevention of behaviour problems AN - 1673613627 AB - The Good Behaviour Game (GBG) has been shown to be effective in preventing childhood disruptive behaviours and their long-term unfavourable health-related outcomes. Like many other evidence-based preventive health programmes, however, its current use in Dutch primary schools is limited, and knowledge of the factors influencing the adoption of the programme is scarce. This study aimed to provide a theory-based description of the GBG adoption process and to examine factors influencing this process in primary schools in Amsterdam. In this mixed-methods observational study, semi-structured face-to-face interviews with decision makers from schools that did (n=11), and did not (n=6), adopt the programme were supplemented with structured telephone interviews with non-adopters (n=39). Based on Rogers' Diffusion Theory, the qualitative data were analysed using a deductive approach. Factors facilitating the adoption of the GBG were specific school needs and problems, formulated in educational rather than health terms, and the visibility of the programme's positive effects. Factors impeding adoption were competing programmes in schools and being unaware of favourable funding opportunities. In contrast to previous studies, 'time investment' did not play an impeding role. Adoption of prevention programmes in schools may benefit from framing dissemination strategies in educational terms, and using self-assessment procedures to reveal specific needs/problems and to create a 'readiness to change'. In addition, adoption may benefit from using active dissemination strategies, including opinion leaders reporting their positive experiences with the programme, and the termination of any ineffective programmes that schools currently use. JF - The Health Education Journal AU - Dijkman, Marieke AM AU - Harting, Janneke AU - van der Wal, Marcel F AD - Public Health Service Amsterdam (GGD), Cluster E&G, Amsterdam, The Netherlands ; Department of Social Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands ; Public Health Service Amsterdam (GGD), Cluster E&G, Amsterdam, The Netherlands Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 168 EP - 182 CY - London PB - SAGE PUBLICATIONS, INC. VL - 74 IS - 2 SN - 0017-8969 KW - Medical Sciences KW - Evidence-based programmes KW - behaviour problems KW - primary schools KW - adoption KW - dissemination KW - Behavioural problems KW - Evidence based KW - Preventive programmes KW - Amsterdam Netherlands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673613627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Health+Education+Journal&rft.atitle=Adoption+of+the+Good+Behaviour+Game%3A+An+evidence-based+intervention+for+the+prevention+of+behaviour+problems&rft.au=Dijkman%2C+Marieke+AM%3BHarting%2C+Janneke%3Bvan+der+Wal%2C+Marcel+F&rft.aulast=Dijkman&rft.aufirst=Marieke&rft.date=2015-02-01&rft.volume=74&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=The+Health+Education+Journal&rft.issn=00178969&rft_id=info:doi/10.1177%2F0017896914522234 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-03-24 N1 - Last updated - 2016-09-08 N1 - SubjectsTermNotLitGenreText - Amsterdam Netherlands DO - http://dx.doi.org/10.1177/0017896914522234 ER - TY - JOUR T1 - Ten-year retrospective assessment of the performance of the Food Contact Notification (FCN) programme AN - 1668270731; PQ0001113954 AB - The Food Contact Notification (FCN) programme was authorised by the US Food and Drug Administration (USFDA) Modernization Act of 1997. Manufacturers may file FCNs for food contact substances (FCSs) not already authorised or pre-sanctioned by the USFDA by demonstrating a reasonable certainty of no harm for their intended uses. The Division of Food Contact Notifications (DFCN) 10-year Retrospective Assessment Group was formed to collect and develop metrics associated with the first decade of the FCN Programme and determine the extent selected aspects of the review process contributed to the effective FCN. Comparative analysis of 924 FCNs revealed that 76% become effective, 23% were withdrawn and 1% received a not accepted status. The focus of the Group was to identify factors impacting the likelihood of an FCN becoming effective. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Neal-Kluever, April AU - Cooper, Jessica AU - Zebovitz, Thomas C AU - Butts, Kyla M AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Food Contact Notifications, College Park, MD, USA Y1 - 2015/02/01/ PY - 2015 DA - 2015 Feb 01 SP - 261 EP - 270 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 2 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Risk assessment KW - Food additives KW - Reviews KW - Drugs KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668270731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Ten-year+retrospective+assessment+of+the+performance+of+the+Food+Contact+Notification+%28FCN%29+programme&rft.au=Neal-Kluever%2C+April%3BCooper%2C+Jessica%3BZebovitz%2C+Thomas+C%3BButts%2C+Kyla+M&rft.aulast=Neal-Kluever&rft.aufirst=April&rft.date=2015-02-01&rft.volume=32&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2014.994112 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Reviews; Drugs DO - http://dx.doi.org/10.1080/19440049.2014.994112 ER - TY - JOUR T1 - A novel method for the simultaneous determination of 14 sweeteners of regulatory interest using UHPLC-MS/MS AN - 1668270599; PQ0001113953 AB - An improved, efficient, sensitive method for the determination of 14 non-nutritive sweeteners in food products was developed using electrospray ionisation (ESI) ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in the negative-ion mode. Fourteen sweeteners and three internal standards were separated on a reversed-phase UHPLC column using a simple gradient programme. Analyte quantitation and confirmation were performed with data collection in multiple reaction monitoring (MRM) mode. Limits of detection (LODs) were determined in a representative drink, candy and yogurt sample and ranged from 0.1 to 1.8 ng ml super(-1) (drinks) and from 0.1 to 2.5 ng g super(-1) (candy and yogurt). Repeatability at the limit of quantitation (LOQ) ranged from 1% to 13% relative standard deviation (RSD). Twenty-seven commercially available food products were tested using the optimised method showing that the majority of products contained sweetener concentrations below their assigned maximum usable dose. Recovery studies were performed and accuracy data are presented. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Shah, Romina AU - Farris, Samantha AU - De Jager, Lowri S AU - Begley, Timothy H AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA Y1 - 2015/02/01/ PY - 2015 DA - 2015 Feb 01 SP - 141 EP - 151 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 2 SN - 1944-0049, 1944-0049 KW - Pollution Abstracts; Risk Abstracts KW - Risk assessment KW - Pollution monitoring KW - Data collection KW - Food additives KW - Mass spectrometry KW - P 9999:GENERAL POLLUTION KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668270599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=A+novel+method+for+the+simultaneous+determination+of+14+sweeteners+of+regulatory+interest+using+UHPLC-MS%2FMS&rft.au=Shah%2C+Romina%3BFarris%2C+Samantha%3BDe+Jager%2C+Lowri+S%3BBegley%2C+Timothy+H&rft.aulast=Shah&rft.aufirst=Romina&rft.date=2015-02-01&rft.volume=32&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2014.994111 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Risk assessment; Pollution monitoring; Food additives; Data collection; Mass spectrometry DO - http://dx.doi.org/10.1080/19440049.2014.994111 ER - TY - JOUR T1 - Occupational exposures associated with severe exacerbation of asthma AN - 1668261708; PQ0001170312 AB - BACKGROUND: The exacerbation of asthma by workplace conditions is common, but little is known about which agents pose a risk. OBJECTIVE: We used data from an existing survey of adults with asthma to identify occupational exposures associated with severe exacerbation of asthma. DESIGN: Questionnaires were completed by 557 working adults with asthma. Severe exacerbation of asthma in the past 12 months was defined as asthma-related hospitalization, or reports of both unplanned asthma care and treatment with a short course of oral corticosteroids. Occupational exposures for the same time period were assessed using an asthma-specific job exposure matrix. We modeled severe exacerbation to yield prevalence ratios (PRs) for exposures while controlling for potential confounders. RESULTS: A total of 164 participants (29%) were positive for severe exacerbation, and 227 (40.8%) were assessed as being exposed to asthma agents at work. Elevated PRs were observed for several specific agents, notably the irritant subcategories of environmental tobacco smoke (PR 1.84, 95%CI 1.34-2.51) among all participants, inorganic dusts (PR 2.53, 95%CI 1.37-4.67) among men, and the low molecular weight subcategory of other highly reactive agents (PR 1.97, 95%CI 1.08-3.60) among women. CONCLUSION: Among working adults with asthma, severe exacerbation was associated with several occupational agents. JF - International Journal of Tuberculosis and Lung Disease AU - Henneberger, P K AU - Liang, X AU - Lillienberg, L AU - Dahlman-Hoglund, A AU - Toren, K AU - Andersson, E AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS H2800, Morgantown, WV 26505, USA, pkh0@cdc.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 244 EP - 250 PB - International Union Against Tuberculosis and Lung Disease, 68 bvd Saint-Michel Paris 75006 France VL - 19 IS - 2 SN - 1027-3719, 1027-3719 KW - Risk Abstracts; Health & Safety Science Abstracts KW - work-exacerbated asthma KW - job-exposure matrix KW - occupational epidemiology KW - Risk assessment KW - Corticoids KW - Passive smoking KW - Mycobacterium KW - Lung KW - Asthma KW - Tuberculosis KW - Respiratory diseases KW - Occupational exposure KW - Dust KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668261708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Occupational+exposures+associated+with+severe+exacerbation+of+asthma&rft.au=Henneberger%2C+P+K%3BLiang%2C+X%3BLillienberg%2C+L%3BDahlman-Hoglund%2C+A%3BToren%2C+K%3BAndersson%2C+E&rft.aulast=Henneberger&rft.aufirst=P&rft.date=2015-02-01&rft.volume=19&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/10.5588%2Fijtld.14.0132 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Risk assessment; Corticoids; Passive smoking; Lung; Asthma; Tuberculosis; Respiratory diseases; Dust; Occupational exposure; Mycobacterium DO - http://dx.doi.org/10.5588/ijtld.14.0132 ER - TY - JOUR T1 - Tuberculosis misclassification among resettled refugees in Buffalo, New York, USA AN - 1668259385; PQ0001170310 AB - BACKGROUND: Discordance in the classification of tuberculosis (TB) disease overseas compared to classification in the United States has been observed among immigrant populations. OBJECTIVE: To examine TB misclassification among recently resettled refugees in Buffalo, NY, between 2005 and 2012. METHODS: Retrospective study of refugees resettled to Buffalo from 2005 to 2012 and evaluated at a refugee/community health center. Centers for Disease Control and Prevention (CDC) Division of Global Migration and Quarantine (DGMQ) Class B1-B3 and American Thoracic Society (ATS) Class 2 (LTBI) cases were abstracted. Independent variables were demographics, countries of origin and refugee camp internment, year of resettlement, purified protein derivative induration, and chest X-ray findings, while CDC DGMQ and ATS classification were dependent variables. Independent samples Mest and analysis of variance were performed. RESULTS: Of 284 charts reviewed, 233 (81.2%) were misclassified. Among 101 cases of LTBI (B1/B2) diagnosed outside the United States, 51 (50.5%) were overdiagnosed. Underdiagnoses occurred among 181/182 refugees (99.5%) originally classified as normal overseas. CONCLUSION: These findings suggest that TB misclassification among recent immigrants remains widespread. Screening procedures both before and after resettlement should be better synchronized. Public health implications range from morbidity and costs of unnecessary treatment to the spread of a highly communicable disease. JF - International Journal of Tuberculosis and Lung Disease AU - Evans, T B AU - Mador, M J AU - Glick, M AU - Ahmad, I AD - Department of Social & Preventive Medicine, School of Public Health & Health Professions, State University of New York at Buffalo, Buffalo; Indian Health Service, US Department of Health and Human Services, Fort Washakie Health Center, PO Box 128, Fort Washakie, WY 82514, USA, te2105@columbia.edu Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 231 EP - 236 PB - International Union Against Tuberculosis and Lung Disease, 68 bvd Saint-Michel Paris 75006 France VL - 19 IS - 2 SN - 1027-3719, 1027-3719 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - TB misclassification KW - refugees KW - Buffalo KW - NY KW - LTBI KW - tuberculosis KW - USA, New York, Buffalo KW - Mycobacterium KW - Disease control KW - Chest KW - Refugees KW - Migration KW - Morbidity KW - Public health KW - Demography KW - Classification KW - Discordance KW - Thorax KW - Tuberculosis KW - Cyclic AMP KW - Immigrants KW - Lung diseases KW - USA, New York KW - Prevention KW - Lung KW - Reviews KW - Ionizing radiation KW - Proteins KW - Quarantine KW - Tuberculin KW - H 12000:Epidemiology and Public Health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668259385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Tuberculosis+misclassification+among+resettled+refugees+in+Buffalo%2C+New+York%2C+USA&rft.au=Evans%2C+T+B%3BMador%2C+M+J%3BGlick%2C+M%3BAhmad%2C+I&rft.aulast=Evans&rft.aufirst=T&rft.date=2015-02-01&rft.volume=19&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/10.5588%2Fijtld.14.0272 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Cyclic AMP; Lung diseases; Immigrants; Disease control; Chest; Migration; Morbidity; Public health; Demography; Ionizing radiation; Reviews; Discordance; Thorax; Quarantine; Tuberculosis; Tuberculin; Refugees; Prevention; Classification; Lung; Proteins; Mycobacterium; USA, New York, Buffalo; USA, New York DO - http://dx.doi.org/10.5588/ijtld.14.0272 ER - TY - JOUR T1 - PUBLIC HEALTH AND MEDICAL PREPAREDNESS FOR A NUCLEAR DETONATION: THE NUCLEAR INCIDENT MEDICAL ENTERPRISE AN - 1668253928; PQ0001237865 AB - Resilience and the ability to mitigate the consequences of a nuclear incident are enhanced by (1) effective planning, preparation and training; (2) ongoing interaction, formal exercises, and evaluation among the sectors involved; (3) effective and timely response and communication; and (4) continuous improvements based on new science, technology, experience, and ideas. Public health and medical planning require a complex, multi-faceted systematic approach involving federal, state, local, tribal, and territorial governments; private sector organizations; academia; industry; international partners; and individual experts and volunteers. The approach developed by the U.S. Department of Health and Human Services Nuclear Incident Medical Enterprise (NIME) is the result of efforts from government and nongovernment experts. It is a "bottom-up" systematic approach built on the available and emerging science that considers physical infrastructure damage, the spectrum of injuries, a scarce resources setting, the need for decision making in the face of a rapidly evolving situation with limited information early on, timely communication, and the need for tools and just-in-time information for responders who will likely be unfamiliar with radiation medicine and uncertain and overwhelmed in the face of the large number of casualties and the presence of radioactivity. The components of NIME can be used to support planning for, response to, and recovery from the effects of a nuclear incident Recognizing that it is a continuous work-in-progress, the current status of the public health and medical preparedness and response for a nuclear incident is provided. JF - Health Physics AU - Coleman, C Norman AU - Sullivan, Julie M AU - Bader, Judith L AU - Murrain-Hill, Paula AU - Koemer, John F AU - Garrett, Andrew L AU - Weinstock, David M AU - Case, Cullen Jr AU - Hrdina, Chad AU - Adams, Steven A AD - Office of Emergency Management, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC; Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, ccoleman@mail.nih.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 149 EP - 160 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 108 IS - 2 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts KW - National Council on Radiation Protection and Measurements KW - emergency planning KW - nuclear war KW - radiological terrorism KW - France, Languedoc-Roussillon, Nimes KW - Infrastructure KW - Decision making KW - Communications KW - Radiation KW - Injuries KW - Training KW - Radioactivity KW - Private sector KW - Public health KW - Technology KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668253928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=PUBLIC+HEALTH+AND+MEDICAL+PREPAREDNESS+FOR+A+NUCLEAR+DETONATION%3A+THE+NUCLEAR+INCIDENT+MEDICAL+ENTERPRISE&rft.au=Coleman%2C+C+Norman%3BSullivan%2C+Julie+M%3BBader%2C+Judith+L%3BMurrain-Hill%2C+Paula%3BKoemer%2C+John+F%3BGarrett%2C+Andrew+L%3BWeinstock%2C+David+M%3BCase%2C+Cullen+Jr%3BHrdina%2C+Chad%3BAdams%2C+Steven+A&rft.aulast=Coleman&rft.aufirst=C&rft.date=2015-02-01&rft.volume=108&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0000000000000249 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Infrastructure; Decision making; Communications; Injuries; Radiation; Training; Radioactivity; Private sector; Technology; Public health; France, Languedoc-Roussillon, Nimes DO - http://dx.doi.org/10.1097/HP.0000000000000249 ER - TY - JOUR T1 - National Survey of US Long-Haul Truck Driver Health and Injury: Health Behaviors AN - 1668247793; PQ0001261243 AB - Objective: To compare selected health behaviors and body mass index (modifiable risk factors) of US long-haul truck drivers to the US working population by sex. Methods: The National Survey of US Long-Haul Truck Driver Health and Injury interviewed a nationally representative sample of long-haul truck drivers (n = 1265) at truck stops. Age-adjusted results were compared with national health surveys. Results: Compared with US workers, drivers had significantly higher body mass index, current cigarette use, and pack-years of smoking; lower prevalence of annual influenza vaccination; and generally lower alcohol consumption. Physical activity level was low for most drivers, and 25% had never had their cholesterol levels tested. Conclusions: Working conditions common to long-haul trucking may create significant barriers to certain healthy behaviors; thus, transportation and health professionals should address the unique work environment when developing interventions for long-haul drivers. JF - Journal of Occupational and Environmental Medicine AU - Birdsey, Jan AU - Sieber, W Karl AU - Chen, Guang X AU - Hitchcock, Edward M AU - Lincoln, Jennifer E AU - Nakata, Akinori AU - Robinson, Cynthia F AU - Sweeney, Marie H AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, MS-R17, Cincinnati, OH 45226; Division of Surveillance, Hazard Evaluations, and Field Studies, JBirdsey@cdc.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 210 EP - 216 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 2 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Alcohol KW - Cigarettes KW - Injuries KW - Physical activity KW - Body mass KW - Intervention KW - Cholesterol KW - Working conditions KW - Influenza KW - Transportation KW - Behavior KW - Risk factors KW - Trucks KW - Vaccines KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668247793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=National+Survey+of+US+Long-Haul+Truck+Driver+Health+and+Injury%3A+Health+Behaviors&rft.au=Birdsey%2C+Jan%3BSieber%2C+W+Karl%3BChen%2C+Guang+X%3BHitchcock%2C+Edward+M%3BLincoln%2C+Jennifer+E%3BNakata%2C+Akinori%3BRobinson%2C+Cynthia+F%3BSweeney%2C+Marie+H&rft.aulast=Birdsey&rft.aufirst=Jan&rft.date=2015-02-01&rft.volume=57&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000338 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-29 N1 - SubjectsTermNotLitGenreText - Alcohol; Injuries; Cigarettes; Body mass; Physical activity; Intervention; Cholesterol; Working conditions; Influenza; Transportation; Behavior; Risk factors; Trucks; Vaccines DO - http://dx.doi.org/10.1097/JOM.0000000000000338 ER - TY - JOUR T1 - Effects of Maternal and Lactational Exposure to 2-Hydroxy-4-Methoxybenzone on Development and Reproductive Organs in Male and Female Rat Offspring AN - 1664209208; PQ0001179074 AB - BACKGROUND 2-Hydroxy-4-methoxybenzophenone (HMB) is an ultraviolet (UV) absorbing compound used in many cosmetic products as a UV-protecting agent and in plastics for preventing UV-induced photodecomposition. HMB has been detected in over 95% of randomly collected human urine samples from adults and from premature infants, and it may have estrogenic potential. METHODS To determine the effects of maternal and lactational exposure to HMB on development and reproductive organs of offspring, time-mated female Harlan Sprague-Dawley rats were dosed with 0, 1000, 3000, 10,000, 25,000, or 50,000 ppm HMB (seven to eight per group) added to chow from gestation day 6 until weaning on postnatal day (PND) 23. RESULTS AND CONCLUSION Exposure to HMB was associated with reduced body and organ weights in female and male offspring. No significant differences were observed in the number of implantation sites/litter, mean resorptions/litter, % litters with resorptions, number and weights of live fetuses, or sex ratios between the control and HMB dose groups. Normalized anogenital distance in male pups at PND 23 was decreased in the highest dose group. Spermatocyte development was impaired in testes of male offspring in the highest dose group. In females, follicular development was delayed in the highest dose group. However, by evaluating levels of the compound in rat serum, the doses at which adverse events occurred are much higher than usual human exposure levels. Thus, exposure to less than 10,000 ppm HMB does not appear to be associated with adverse effects on the reproductive system in rats JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Nakamura, Noriko AU - Inselman, Amy L AU - White, Gene A AU - Chang, Ching-Wei AU - Trbojevich, Raul A AU - Sephr, Estatira AU - Voris, Kristie L AU - Patton, Ralph E AU - Bryant, Matthew S AU - Harrouk, Wafa AU - McIntyre, Barry S AU - Foster, Paul MD AU - Hansen, Deborah K AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas. Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 35 EP - 51 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 1 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - Testes KW - Litter KW - Sex ratio KW - Anogenital KW - Weaning KW - Cosmetics KW - Development KW - Reproductive system KW - Spermatocytes KW - Fetuses KW - U.V. radiation KW - Urine KW - Gestation KW - Congenital defects KW - Progeny KW - Reproductive organs KW - Plastics KW - Side effects KW - Infants KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664209208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=Effects+of+Maternal+and+Lactational+Exposure+to+2-Hydroxy-4-Methoxybenzone+on+Development+and+Reproductive+Organs+in+Male+and+Female+Rat+Offspring&rft.au=Nakamura%2C+Noriko%3BInselman%2C+Amy+L%3BWhite%2C+Gene+A%3BChang%2C+Ching-Wei%3BTrbojevich%2C+Raul+A%3BSephr%2C+Estatira%3BVoris%2C+Kristie+L%3BPatton%2C+Ralph+E%3BBryant%2C+Matthew+S%3BHarrouk%2C+Wafa%3BMcIntyre%2C+Barry+S%3BFoster%2C+Paul+MD%3BHansen%2C+Deborah+K&rft.aulast=Nakamura&rft.aufirst=Noriko&rft.date=2015-02-01&rft.volume=104&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrb.21137 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Testes; Litter; Sex ratio; Anogenital; Weaning; Cosmetics; Development; Fetuses; Spermatocytes; Reproductive system; U.V. radiation; Urine; Gestation; Congenital defects; Progeny; Plastics; Reproductive organs; Side effects; Infants DO - http://dx.doi.org/10.1002/bdrb.21137 ER - TY - JOUR T1 - Cerium dioxide nanoparticles protect against oxidative stress induced injury through modulation of TGF- beta signalling AN - 1664207311; PQ0001183913 AB - Cerium dioxide nanoparticles have many applications including use as a diesel fuel additive. Concerns over the increased use of engineered nanoparticles and the potential risks to the public have led many studies to investigate the health impacts after nanomaterial exposure. For CeO sub(2) nanoparticles, some studies report oxidative stress leading to a loss of cell viability, where others report the opposite, observing protective effects against oxidative stress induced injury. Due to a lack of consensus over the precise physiological effects surrounding CeO sub(2) exposure, we set out to investigate how these particles influence oxidative stress induced injury. To model the lung as a primary exposure location we used alveolar type II epithelial cells (A549) incubated with CeO sub(2) nanoparticles, prior to an oxidative stress event using either H sub(2)O sub(2) or Menadione. Nanoparticle exposure protected against oxidant-induced injury but this was not paralleled by a reduction in the oxidative stress markers such as protein carbonylation or expression of EGR1 and NQO1. Using gene expression profiling TGF- beta signalling was identified as a candidate mechanism through which the CeO sub(2) nanoparticles were having their protective effects. Using recombinant transforming growth factor beta 1 (TGF- beta 1) we demonstrate protective effects on oxidant-induced injury paralleled by alterations in TGF- beta pathway related gene expression similar to those observed with CeO sub(2) nanoparticle addition. These results represent an important addition to our understanding of the biological effects of CeO sub(2) nanoparticles and identify TGF- beta signalling as a potential mechanistic regulator for their cyto-protective ability. JF - Toxicology Research AU - Guo, Chang AU - Smith, Rachel AU - Gant, Timothy W AU - Leonard, Martin O AD - Centre for Radiation; Chemical and Environmental Hazards; Public Health England; Oxfordshire OX11 0RQ; UK; +44 (0)12358 25164; , Martin.Leonard@phe.gov.uk Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 464 EP - 475 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 4 IS - 2 SN - 2045-452X, 2045-452X KW - Toxicology Abstracts KW - Transforming growth factor- beta 1 KW - Epithelial cells KW - Injuries KW - Fuels KW - Alveoli KW - Gene expression KW - Hydrogen peroxide KW - Oxidative stress KW - Lung KW - Transforming growth factor- beta KW - Menadione KW - NAD(P)H dehydrogenase (quinone) KW - Diesel KW - EGR-1 protein KW - nanoparticles KW - Signal transduction KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664207311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Research&rft.atitle=Cerium+dioxide+nanoparticles+protect+against+oxidative+stress+induced+injury+through+modulation+of+TGF-+beta+signalling&rft.au=Guo%2C+Chang%3BSmith%2C+Rachel%3BGant%2C+Timothy+W%3BLeonard%2C+Martin+O&rft.aulast=Guo&rft.aufirst=Chang&rft.date=2015-02-01&rft.volume=4&rft.issue=2&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=Toxicology+Research&rft.issn=2045452X&rft_id=info:doi/10.1039%2Fc4tx00210e LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 52 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Transforming growth factor- beta 1; Epithelial cells; Injuries; Fuels; Alveoli; Gene expression; Lung; Oxidative stress; Hydrogen peroxide; Transforming growth factor- beta; Menadione; Diesel; NAD(P)H dehydrogenase (quinone); nanoparticles; EGR-1 protein; Signal transduction DO - http://dx.doi.org/10.1039/c4tx00210e ER - TY - JOUR T1 - Nitrate in drinking water and bladder cancer risk in Spain. AN - 1662003271; 25601732 AB - Nitrate is a widespread contaminant in drinking water and ingested nitrate under conditions resulting in endogenous nitrosation is suspected to be carcinogenic. However, the suggested association between nitrate in drinking water and bladder cancer remains inconsistent. We evaluated the long-term exposure to drinking water nitrate as a risk factor for bladder cancer, considering endogenous nitrosation modifiers and other covariables. We conducted a hospital-based case-control study of bladder cancer in Spain (1998-2001). Residential histories and water consumption information were ascertained through personal interviews. Historical nitrate levels (1940-2000) were estimated in study municipalities based on monitoring records and water source. Residential histories of study subjects were linked with nitrate estimates by year and municipality to calculate individual exposure from age 18 to recruitment. We calculated odds ratios (OR) and 95% confidence intervals (CI) for bladder cancer among 531 cases and 556 controls with reliable interviews and nitrate exposure information covering at least 70% of years from age 18 to interview. Average residential levels ranged from 2.1mg/L to 12.0mg/L among regions. Adjusted OR (95%CI) for average residential levels relative to ≤ 5 mg/L were 1.2 (0.7-2.0) for >5-10mg/L and 1.1 (0.6-1.9) for >10mg/L. The OR for subjects with longest exposure duration (>20 years) to highest levels (>9.5mg/L) was 1.4 (0.9-2.3). Stratification by intake of vitamin C, vitamin E, meat, and gastric ulcer diagnosis did not modify these results. A non-significant negative association was found with waterborne ingested nitrate with an OR of 0.7 (0.4-1.0) for >8 vs. ≤ 4 mg/day. Adjustment for several covariables showed similar results to crude analyses. Bladder cancer risk was inconsistently associated with chronic exposure to drinking water nitrate at levels below the current regulatory limit. Elevated risk is suggested only among subjects with longest exposure duration to the highest levels. No evidence of interaction with endogenous nitrosation modifiers was observed. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Environmental research AU - Espejo-Herrera, Nadia AU - Cantor, Kenneth P AU - Malats, Nuria AU - Silverman, Debra T AU - Tardón, Adonina AU - García-Closas, Reina AU - Serra, Consol AU - Kogevinas, Manolis AU - Villanueva, Cristina M AD - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. ; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. ; Universidad de Oviedo, Oviedo, Spain. ; Hospital Universitario de Canarias, La Laguna, Spain. ; Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain; Consorci Hospitalari Parc Taulí, Sabadell, Spain. ; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; National School of Public Health, Athens, Greece. ; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. Electronic address: cvillanueva@creal.cat. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 299 EP - 307 VL - 137 KW - Carcinogens KW - 0 KW - Drinking Water KW - Nitrates KW - Water Pollutants, Chemical KW - Index Medicus KW - Nitrate KW - Drinking wáter KW - Case-control study KW - Bladder cáncer KW - Water contaminants KW - Environmental Monitoring KW - Animals KW - Risk Factors KW - Humans KW - Cats KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Spain -- epidemiology KW - Male KW - Female KW - Drinking Water -- analysis KW - Water Pollutants, Chemical -- toxicity KW - Urinary Bladder Neoplasms -- epidemiology KW - Nitrates -- toxicity KW - Environmental Exposure KW - Carcinogens -- toxicity KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1662003271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Nitrate+in+drinking+water+and+bladder+cancer+risk+in+Spain.&rft.au=Espejo-Herrera%2C+Nadia%3BCantor%2C+Kenneth+P%3BMalats%2C+Nuria%3BSilverman%2C+Debra+T%3BTard%C3%B3n%2C+Adonina%3BGarc%C3%ADa-Closas%2C+Reina%3BSerra%2C+Consol%3BKogevinas%2C+Manolis%3BVillanueva%2C+Cristina+M&rft.aulast=Espejo-Herrera&rft.aufirst=Nadia&rft.date=2015-02-01&rft.volume=137&rft.issue=&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2014.10.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-04 N1 - Date created - 2015-03-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envres.2014.10.034 ER - TY - JOUR T1 - Analysis of Neisseria gonorrhoeae Azithromycin Susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013 AN - 1660434829; PQ0001092219 AB - Azithromycin, administered with ceftriaxone, is recommended by the CDC for the treatment of gonorrhea. Many experts have expressed concern about the ease with which Neisseria gonorrhoeae can acquire macrolide resistance. We sought to describe gonococcal azithromycin susceptibility in the United States and to determine whether azithromycin susceptibility has changed over time. We analyzed data from 2005 to 2013 from the Gonococcal Isolate Surveillance Project, a CDC-supported sentinel surveillance network that monitors gonococcal antimicrobial susceptibility. A total of 44,144 N. gonorrhoeae isolates were tested for azithromycin susceptibility by agar dilution methods. The overall azithromycin MIC50 was 0.25 mu g/ml, and the MIC90 was 0.5 mu g/ml. There were no overall temporal trends in geometric means. Isolates from men who had sex with men had significantly higher geometric mean MICs than isolates from men who had sex exclusively with women. The overall prevalence of reduced azithromycin susceptibility (MIC, greater than or equal to 2 mu g/ml) was 0.4% and varied by year from 0.3% (2006 and 2009) to 0.6% (2013). We did not find a clear temporal trend in gonococcal azithromycin MICs in the United States, and the prevalence of reduced azithromycin susceptibility remains low. These findings support the continued use of azithromycin in a combination therapy regimen for gonorrhea. JF - Antimicrobial Agents & Chemotherapy AU - Kirkcaldy, Robert D AU - Soge, Olusegun AU - Papp, John R AU - Hook, Edward W, III AU - Rio, Carlos del AU - Kubin, Grace AU - Weinstock, Hillard S AD - Division of STD Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia, USA, rkirkcaldy@cdc.gov. Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 998 EP - 1003 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Agar KW - Data processing KW - Azithromycin KW - Gonorrhea KW - Ceftriaxone KW - Minimum inhibitory concentration KW - Neisseria gonorrhoeae KW - Sex KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660434829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Analysis+of+Neisseria+gonorrhoeae+Azithromycin+Susceptibility+in+the+United+States+by+the+Gonococcal+Isolate+Surveillance+Project%2C+2005+to+2013&rft.au=Kirkcaldy%2C+Robert+D%3BSoge%2C+Olusegun%3BPapp%2C+John+R%3BHook%2C+Edward+W%2C+III%3BRio%2C+Carlos+del%3BKubin%2C+Grace%3BWeinstock%2C+Hillard+S&rft.aulast=Kirkcaldy&rft.aufirst=Robert&rft.date=2015-02-01&rft.volume=59&rft.issue=2&rft.spage=998&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.04337-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 41 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Agar; Data processing; Azithromycin; Gonorrhea; Ceftriaxone; Minimum inhibitory concentration; Antimicrobial agents; Sex; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1128/AAC.04337-14 ER - TY - JOUR T1 - Muscular activity of lower limb muscles associated with working on inclined surfaces AN - 1660428171; PQ0001027404 AB - This study investigated the effects of visual cues, muscular fatigue, task performance and experience of working on inclined surfaces on activity of postural muscles in the lower limbs associated with maintaining balance on three inclined surfaces - 0 degree , 14 degree and 26 degree . Normalised electromyographic (NEMG) data were collected in 44 professional roofers bilaterally from the rectus femoris, biceps femoris, tibialii anterior and gastrocnemii medial muscle groups. The 50th and 95th percentile NEMG amplitudes were used as EMG variables. Results showed that inclination angle and task performance caused a significant increase in the NEMG amplitudes of all postural muscles. Visual cues were significantly associated with a decrease in the 95th percentile EMG amplitude for the right gastrocnemius medial and tibialis anterior. Fatigue was related to a significant decrease in the NEMG amplitude for the rectus femoris. Experience of working on inclined surfaces did not have a significant effect on the NEMG amplitude. Practitioner Summary: Increasing angle of the working surface and task performance are two main factors contributing to muscular loading in the lower limb muscles. Input of visual cues while working on inclined surfaces may provide beneficial effects on reducing muscular loading to prevent occupational falls. JF - Ergonomics AU - Lu, Ming-Lun AU - Kincl, Laurel AU - Lowe, Brian AU - Succop, Paul AU - Bhattacharya, Amit AD - Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH45226, USA Y1 - 2015/02/01/ PY - 2015 DA - 2015 Feb 01 SP - 278 EP - 290 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 58 IS - 2 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts KW - EMG KW - postural stability KW - visual cues KW - fatigue KW - inclined surfaces KW - Fatigue KW - Muscles KW - Posture KW - Ergonomics KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660428171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Muscular+activity+of+lower+limb+muscles+associated+with+working+on+inclined+surfaces&rft.au=Lu%2C+Ming-Lun%3BKincl%2C+Laurel%3BLowe%2C+Brian%3BSuccop%2C+Paul%3BBhattacharya%2C+Amit&rft.aulast=Lu&rft.aufirst=Ming-Lun&rft.date=2015-02-01&rft.volume=58&rft.issue=2&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140139.2014.968634 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Fatigue; Muscles; Posture; Ergonomics DO - http://dx.doi.org/10.1080/00140139.2014.968634 ER - TY - JOUR T1 - The MCH Training Program: Developing MCH Leaders that are Equipped for the Changing Health Care Landscape AN - 1660417222; PQ0001064670 AB - This article examines the success of the Maternal and Child Health (MCH) Bureau's MCH Training Program in producing the next generation of MCH leaders, equipped with interdisciplinary, leadership skills necessary for the changing health care landscape. A secondary data analysis of performance measure data (2007-2011) collected through the discretionary grant information system was performed. Grantees were grouped by grant program (n = 10) for this analysis. Outcomes of interest 5 years post-program completion included: (1) the percentage of long-term training program graduates who demonstrate field leadership; (2) the percentage of long-term trainees (LTT) who remain in MCH, work with underserved and/or vulnerable populations, or work in a public health agency/organization; and (3) the percentage of LTT working in an interdisciplinary manner to serve the MCH population. Summary output data on the number of LTT reached was also calculated. The number of LTT participating in the MCH Training Program increased between 2007 and 2011. Over 84 % of LTT demonstrate field leadership 5 years after program completion, while 78.2 % of LTT remain in MCH work and 83 % are working with underserved or vulnerable populations. At 5-years post-program completion, over 75 % of LTT are working in an interdisciplinary manner to serve the MCH population. The MCH Training Program has produced well-positioned leaders. Continued investment in the MCH Training Program is critical to ensure a well-trained pipeline of health professionals equipped to address the special health needs of MCH populations in an evolving health system. JF - Maternal and Child Health Journal AU - Kavanagh, Laura AU - Menser, Michelle AU - Pooler, Jennifer AU - Mathis, Sheryl AU - Ramos, Lauren Raskin AD - Division of Maternal and Child Health Workforce Development, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, USA, lkavanagh@hrsa.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 257 EP - 264 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 19 IS - 2 SN - 1092-7875, 1092-7875 KW - Health & Safety Science Abstracts KW - Health care KW - Training KW - Grants KW - Landscape KW - Vulnerability KW - Pipelines KW - Public health KW - Information systems KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660417222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maternal+and+Child+Health+Journal&rft.atitle=The+MCH+Training+Program%3A+Developing+MCH+Leaders+that+are+Equipped+for+the+Changing+Health+Care+Landscape&rft.au=Kavanagh%2C+Laura%3BMenser%2C+Michelle%3BPooler%2C+Jennifer%3BMathis%2C+Sheryl%3BRamos%2C+Lauren+Raskin&rft.aulast=Kavanagh&rft.aufirst=Laura&rft.date=2015-02-01&rft.volume=19&rft.issue=2&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Maternal+and+Child+Health+Journal&rft.issn=10927875&rft_id=info:doi/10.1007%2Fs10995-014-1574-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 17 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Health care; Training; Landscape; Grants; Pipelines; Vulnerability; Information systems; Public health DO - http://dx.doi.org/10.1007/s10995-014-1574-0 ER - TY - JOUR T1 - Influenza Virus M2 Protein Ion Channel Activity Helps To Maintain Pandemic 2009 H1N1 Virus Hemagglutinin Fusion Competence during Transport to the Cell Surface AN - 1660413830; PQ0001092582 AB - The influenza virus hemagglutinin (HA) envelope protein mediates virus entry by first binding to cell surface receptors and then fusing viral and endosomal membranes during endocytosis. Cleavage of the HA precursor (HA0) into a surface receptor-binding subunit (HA1) and a fusion-inducing transmembrane subunit (HA2) by host cell enzymes primes HA for fusion competence by repositioning the fusion peptide to the newly created N terminus of HA2. We previously reported that the influenza virus M2 protein enhances pandemic 2009 influenza A virus [(H1N1)pdm09] HA-pseudovirus infectivity, but the mechanism was unclear. In this study, using cell-cell fusion and HA-pseudovirus infectivity assays, we found that the ion channel function of M2 was required for enhancement of HA fusion and HA-pseudovirus infectivity. The M2 activity was needed only during HA biosynthesis, and proteolysis experiments indicated that M2 proton channel activity helped to protect (H1N1)pdm09 HA from premature conformational changes as it traversed low-pH compartments during transport to the cell surface. While M2 has previously been shown to protect avian influenza virus HA proteins of the H5 and H7 subtypes that have polybasic cleavage motifs, this study demonstrates that M2 can protect HA proteins from human H1N1 strains that lack a polybasic cleavage motif. This finding suggests that M2 proton channel activity may play a wider role in preserving HA fusion competence among a variety of HA subtypes, including HA proteins from emerging strains that may have reduced HA stability. IMPORTANCE Influenza virus infects cells when the hemagglutinin (HA) surface protein undergoes irreversible pH-induced conformational changes after the virus is taken into the cell by endocytosis. HA fusion competence is primed when host cell enzymes cleave the HA precursor. The proton channel function of influenza virus M2 protein has previously been shown to protect avian influenza virus HA proteins that contain a polybasic cleavage site from pH-induced conformational changes during biosynthesis, but this effect is less well understood for human influenza virus HA proteins that lack polybasic cleavage sites. Using assays that focus on HA entry and fusion, we found that the M2 protein also protects (H1N1)pdm09 influenza A virus HA from premature conformational changes as it transits low-pH compartments during biosynthesis. This work suggests that M2 may play a wider role in preserving HA function in a variety of influenza virus subtypes that infect humans and may be especially important for HA proteins that are less stable. JF - Journal of Virology AU - Alvarado-Facundo, Esmeralda AU - Gao, Yamei AU - Ribas-Aparicio, Rosa Maria AU - Jimenez-Alberto, Alicia AU - Weiss, Carol D AU - Wang, Wei AD - Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA, wei.wang@fda.hhs.gov. PY - 2015 SP - 1975 EP - 1985 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 89 IS - 4 SN - 0022-538X, 0022-538X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Proteolysis KW - Biosynthesis KW - Cell surface KW - Membranes KW - Avian influenza virus KW - Channel gating KW - Protons KW - Hemagglutinins KW - Enzymes KW - Cell fusion KW - Influenza KW - Endocytosis KW - Fowl plague KW - pandemics KW - Infectivity KW - Influenza A virus KW - Envelope protein KW - Ion channels KW - Proteins KW - H 2000:Transportation KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660413830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Influenza+Virus+M2+Protein+Ion+Channel+Activity+Helps+To+Maintain+Pandemic+2009+H1N1+Virus+Hemagglutinin+Fusion+Competence+during+Transport+to+the+Cell+Surface&rft.au=Alvarado-Facundo%2C+Esmeralda%3BGao%2C+Yamei%3BRibas-Aparicio%2C+Rosa+Maria%3BJimenez-Alberto%2C+Alicia%3BWeiss%2C+Carol+D%3BWang%2C+Wei&rft.aulast=Alvarado-Facundo&rft.aufirst=Esmeralda&rft.date=2015-02-01&rft.volume=89&rft.issue=4&rft.spage=1975&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.03253-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 70 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Proteolysis; Cell surface; Channel gating; Protons; Hemagglutinins; Enzymes; Cell fusion; Fowl plague; Endocytosis; Infectivity; pandemics; Ion channels; Envelope protein; Influenza; Biosynthesis; Membranes; Proteins; Avian influenza virus; Influenza A virus DO - http://dx.doi.org/10.1128/JVI.03253-14 ER - TY - JOUR T1 - Utilization of Host Iron Sources by Corynebacterium diphtheriae: Multiple Hemoglobin-Binding Proteins Are Essential for the Use of Iron from the Hemoglobin-Haptoglobin Complex AN - 1660411790; PQ0001092407 AB - The use of hemin iron by Corynebacterium diphtheriae requires the DtxR- and iron-regulated ABC hemin transporter HmuTUV and the secreted Hb-binding protein HtaA. We recently described two surface anchored proteins, ChtA and ChtC, which also bind hemin and Hb. ChtA and ChtC share structural similarities to HtaA; however, a function for ChtA and ChtC was not determined. In this study, we identified additional host iron sources that are utilized by C. diphtheriae. We show that several C. diphtheriae strains use the hemoglobin-haptoglobin (Hb-Hp) complex as an iron source. We report that an htaA deletion mutant of C. diphtheriae strain 1737 is unable to use the Hb-Hp complex as an iron source, and we further demonstrate that a chtA-chtC double mutant is also unable to use Hb-Hp iron. Single-deletion mutants of chtA or chtC use Hb-Hp iron in a manner similar to that of the wild type. These findings suggest that both HtaA and either ChtA or ChtC are essential for the use of Hb-Hp iron. Enzyme-linked immunosorbent assay (ELISA) studies show that HtaA binds the Hb-Hp complex, and the substitution of a conserved tyrosine (Y361) for alanine in HtaA results in significantly reduced binding. C. diphtheriae was also able to use human serum albumin (HSA) and myoglobin (Mb) but not hemopexin as iron sources. These studies identify a biological function for the ChtA and ChtC proteins and demonstrate that the use of the Hb-Hp complex as an iron source by C. diphtheriae requires multiple iron-regulated surface components. JF - Journal of Bacteriology AU - Allen, Courtni E AU - Schmitt, Michael P Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 553 EP - 562 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 197 IS - 3 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Hemopexin KW - Enzyme-linked immunosorbent assay KW - Deletion mutant KW - Alanine KW - human serum albumin KW - Tyrosine KW - Corynebacterium diphtheriae KW - Hemin KW - myoglobin KW - Iron KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660411790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Utilization+of+Host+Iron+Sources+by+Corynebacterium+diphtheriae%3A+Multiple+Hemoglobin-Binding+Proteins+Are+Essential+for+the+Use+of+Iron+from+the+Hemoglobin-Haptoglobin+Complex&rft.au=Allen%2C+Courtni+E%3BSchmitt%2C+Michael+P&rft.aulast=Allen&rft.aufirst=Courtni&rft.date=2015-02-01&rft.volume=197&rft.issue=3&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.02413-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 37 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Hemopexin; Enzyme-linked immunosorbent assay; Deletion mutant; Alanine; Tyrosine; human serum albumin; myoglobin; Hemin; Iron; Corynebacterium diphtheriae DO - http://dx.doi.org/10.1128/JB.02413-14 ER - TY - JOUR T1 - Metal-Mediated Protein Oxidation: Applications of a Modified ELISA-Based Carbonyl Detection Assay for Complex Proteins AN - 1660411079; PQ0001064395 AB - Purpose: Therapeutic proteins are prone to oxidative modification during manufacturing, processing, and storage that may lead to degradation, aggregation, and immunogenicity. Protein carbonylation is an irreversible oxidative modification and has been identified as a hallmark of severe oxidative stress but not extensively studied for its impact on the stability and activity of therapeutic proteins. Methods: We describe the application of a modified ELISA-based method to quantify global levels of carbonyl modification of complex proteins. We investigated protein oxidation of large protein molecules (transferrin, rabbit IgG, or beta -glucosidase) and complex protein samples (human plasma) that were either stored in different buffer formulations, with varying amounts of divalent iron, or under different storage temperatures to determine the impact of different physicochemical stresses on carbonyl modifications. Results: The modified ELISA allows for sensitive and specific carbonyl quantification with measurements that closely match those determined with the conventional spectrophotometric method. The method was useful for complex protein mixtures such as cell lysates without the need for additional procedures to remove DNA and RNA. Our findings demonstrate significant oxidative modification of each of the proteins stored in commonly used buffers and excipients at 37 degree C, 23 degree C, and 4 degree C. The carbonyl levels were further exacerbated with addition of trace amounts of Fe super(2+). We also measured the extent of protein aggregation under oxidizing conditions. Conclusions: Collectively, our results indicate the importance of better characterizing carbonyl modification of proteins during their storage and use. JF - Pharmaceutical Research AU - Uehara, Hiroshi AU - Rao, VAshutosh AD - Laboratory of Chemistry, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 29 Lincoln Drive Bldg 29A, Room 2A-11, Bethesda, Maryland, 20892, USA, ashutosh.rao@fda.hhs.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 691 EP - 701 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 32 IS - 2 SN - 0724-8741, 0724-8741 KW - Toxicology Abstracts KW - Temperature effects KW - Enzyme-linked immunosorbent assay KW - Transferrin KW - RNA KW - Oxidative stress KW - Immunogenicity KW - Immunoglobulin G KW - DNA KW - Spectrophotometry KW - beta -Glucosidase KW - Iron KW - carbonyls KW - Protein interaction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660411079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+Research&rft.atitle=Metal-Mediated+Protein+Oxidation%3A+Applications+of+a+Modified+ELISA-Based+Carbonyl+Detection+Assay+for+Complex+Proteins&rft.au=Uehara%2C+Hiroshi%3BRao%2C+VAshutosh&rft.aulast=Uehara&rft.aufirst=Hiroshi&rft.date=2015-02-01&rft.volume=32&rft.issue=2&rft.spage=691&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+Research&rft.issn=07248741&rft_id=info:doi/10.1007%2Fs11095-014-1496-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 43 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Temperature effects; Enzyme-linked immunosorbent assay; Transferrin; RNA; Immunogenicity; Oxidative stress; DNA; Immunoglobulin G; Spectrophotometry; beta -Glucosidase; carbonyls; Iron; Protein interaction DO - http://dx.doi.org/10.1007/s11095-014-1496-y ER - TY - JOUR T1 - Changes in prevalence of chronic obstructive pulmonary disease and asthma in the US population and associated risk factors AN - 1660405827; PQ0001016374 AB - Chronic lower airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are currently the third leading cause of death in the United States. We aimed to evaluate changes in prevalence of and risk factors for COPD and asthma among the US adult population. We evaluated changes in prevalence of self-reported doctor-diagnosed COPD (i.e. chronic bronchitis and emphysema) and asthma and self-reported respiratory symptoms comparing data from the 1988-1994 and 2007-2010 National Health and Nutrition Examination Surveys. To investigate changes in the severity of each outcome over the two periods, we calculated changes in the proportions of spirometry-based airflow obstruction for each outcome. Prevalence of doctor-diagnosed chronic bronchitis and emphysema decreased significantly mainly among males, while asthma increased only among females. The self-reported disease and the respiratory symptoms were associated with increased prevalence of airflow obstruction for both periods. However, the prevalence of airflow obstruction decreased significantly in the second period among those with shortness of breath and doctor-diagnosed respiratory conditions (chronic bronchitis, emphysema, and asthma). COPD outcomes and asthma were associated with lower education, smoking, underweight and obesity, and occupational dusts and fumes exposure. Chronic lower airway diseases continue to be major public health problems. However, decreased prevalence of doctor-diagnosed chronic bronchitis and emphysema (in males) and decreased prevalence of airflow obstruction in those with respiratory symptoms and doctor-diagnosed respiratory diseases may indicate a declining trend and decrease in disease severity between the two periods. Continued focus on prevention of these diseases through public health interventions is prudent. JF - Chronic Respiratory Disease AU - Halldin, Cara N AU - Doney, Brent C AU - Hnizdo, Eva AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA, Epidemic Intelligence Service Program, Centers for Disease Control and Prevention, Atlanta, GA, USA, challdin@cdc.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 47 EP - 60 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 12 IS - 1 SN - 1479-9723, 1479-9723 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Chronic bronchitis KW - emphysema KW - asthma KW - occupational exposure KW - occupational diseases KW - NHANES KW - Obesity KW - Mortality KW - Intervention KW - Asthma KW - Respiratory diseases KW - Nutrition KW - Dust KW - Chronic obstructive pulmonary disease KW - Public health KW - Health risks KW - USA KW - Prevention KW - Education KW - Risk factors KW - Air flow KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660405827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chronic+Respiratory+Disease&rft.atitle=Changes+in+prevalence+of+chronic+obstructive+pulmonary+disease+and+asthma+in+the+US+population+and+associated+risk+factors&rft.au=Halldin%2C+Cara+N%3BDoney%2C+Brent+C%3BHnizdo%2C+Eva&rft.aulast=Halldin&rft.aufirst=Cara&rft.date=2015-02-01&rft.volume=12&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Chronic+Respiratory+Disease&rft.issn=14799723&rft_id=info:doi/10.1177%2F1479972314562409 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 57 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Mortality; Obesity; Asthma; Intervention; Respiratory diseases; Nutrition; Dust; Public health; Chronic obstructive pulmonary disease; Health risks; Education; Prevention; Risk factors; Air flow; USA DO - http://dx.doi.org/10.1177/1479972314562409 ER - TY - JOUR T1 - Overview of the National Occupational Mortality Surveillance (NOMS) system: Leukemia and acute myocardial infarction risk by industry and occupation in 30 US states 1985-1999, 2003-2004, and 2007 AN - 1660390334; PQ0001048142 AB - Background Cancer and chronic disease are leading causes of death in the US with an estimated cost of $46 billion. Methods We analyzed 11 million cause-specific deaths of US workers age 18-64 years in 30 states during 1985-1999, 2003-2004, and 2007 by occupation, industry, race, gender, and Hispanic origin. Results The highest significantly elevated proportionate leukemia mortality was observed in engineers, protective service, and advertising sales manager occupations and in banks/savings &loans/credit agencies, public safety, and public administration industries. The highest significantly elevated smoking-adjusted acute myocardial infarction mortality was noted in industrial and refractory machinery mechanics, farmers, mining machine operators, and agricultural worker occupations; and wholesale farm supplies, agricultural chemical, synthetic rubber, and agricultural crop industries. Conclusions Significantly elevated risks for acute myocardial infarction and leukemia were observed across several occupations and industries that confirm existing reports and add new information. Interested investigators can access the NOMS website at http://www.cdc.gov/niosh/topics/NOMS/ . Am. J. Ind. Med. 58:123-137, 2015. copyright 2015 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Robinson, Cynthia F AU - Walker, James T AU - Sweeney, Marie H AU - Shen, Rui AU - Calvert, Geoffrey M AU - Schumacher, Pam K AU - Ju, Jun AU - Nowlin, Susan AD - The National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Division of Surveillance, Hazard Evaluation and Field Studies, Cincinnati, Ohio. Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 123 EP - 137 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 2 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Agriculture KW - Age KW - Farms KW - Crops KW - Workers KW - Leukemia KW - Machinery KW - Ethnic groups KW - Races KW - Mortality KW - Loans KW - Safety KW - Rubber KW - Advertising KW - Agrochemicals KW - Cancer KW - Myocardial infarction KW - Health risks KW - Reviews KW - Gender KW - Mining KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660390334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Overview+of+the+National+Occupational+Mortality+Surveillance+%28NOMS%29+system%3A+Leukemia+and+acute+myocardial+infarction+risk+by+industry+and+occupation+in+30+US+states+1985-1999%2C+2003-2004%2C+and+2007&rft.au=Robinson%2C+Cynthia+F%3BWalker%2C+James+T%3BSweeney%2C+Marie+H%3BShen%2C+Rui%3BCalvert%2C+Geoffrey+M%3BSchumacher%2C+Pam+K%3BJu%2C+Jun%3BNowlin%2C+Susan&rft.aulast=Robinson&rft.aufirst=Cynthia&rft.date=2015-02-01&rft.volume=58&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22408 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Agriculture; Mortality; Age; Farms; Rubber; Myocardial infarction; Crops; Cancer; Leukemia; Workers; Reviews; Mining; Races; Loans; Safety; Advertising; Agrochemicals; Health risks; Machinery; Gender; Ethnic groups DO - http://dx.doi.org/10.1002/ajim.22408 ER - TY - JOUR T1 - New insights into the role of the disordered WIP N-terminal domain revealed by NMR structural characterization AN - 1655677033 AB - WASp-interacting protein (WIP) is an intrinsically disordered 503-residue polypeptide with a key role in actin polymerization in activated T cells. Its interaction with actin is mediated by a pair of conserved actin binding motifs (ABMs) at the WIP N-terminus, a domain that has not been investigated in its unbound form. Here we use NMR to investigate the biophysical behavior of the N-terminal ABM in WIP using protonless 13C'-detected spectroscopy. Secondary chemical shifts, residual dipolar couplings and temperature effects identify residual structure throughout the ABM, which exhibits transient helical and [beta]-strand character for residues 30-42 and 44-62, respectively. These observed structural propensities echo the structure observed in the actin-bound state of the ABM. Furthermore, residues preceding the canonical ABM (17-25) and conserved among WIP-related proteins exhibit transient [beta]-strand character, suggesting that the WIPN interaction epitope extends towards the N-terminal polyproline motif. This suggests a possible role for this region in mediating the WIP interaction with polyproline binders such as profilin. In revealing these features of the WIP ABM this study demonstrates the unique ability of NMR in characterizing unstructured domains and provides necessary information for further investigation of WIP-mediated protein-protein interactions. JF - The FEBS Journal AU - Elazari-Shalom, Hila AU - Shaked, Hadassa AU - Esteban-Martin, Santiago AU - Salvatella, Xavier AU - Barda-Saad, Mira AU - Chill, Jordan H Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 700 EP - 714 CY - Oxford PB - Blackwell Publishing Ltd. VL - 282 IS - 4 SN - 1742464X KW - Biology--Biochemistry KW - Proteins KW - Nuclear magnetic resonance--NMR KW - Polymerization KW - Biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1655677033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apqrl&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+FEBS+Journal&rft.atitle=New+insights+into+the+role+of+the+disordered+WIP+N-terminal+domain+revealed+by+NMR+structural+characterization&rft.au=Elazari-Shalom%2C+Hila%3BShaked%2C+Hadassa%3BEsteban-Martin%2C+Santiago%3BSalvatella%2C+Xavier%3BBarda-Saad%2C+Mira%3BChill%2C+Jordan+H&rft.aulast=Elazari-Shalom&rft.aufirst=Hila&rft.date=2015-02-01&rft.volume=282&rft.issue=4&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=The+FEBS+Journal&rft.issn=1742464X&rft_id=info:doi/10.1111%2Ffebs.13174 LA - English DB - ProQuest Central N1 - Copyright - Copyright © 2015 Federation of European Biochemical Societies N1 - Document feature - References N1 - Last updated - 2015-04-13 DO - http://dx.doi.org/10.1111/febs.13174 ER - TY - JOUR T1 - Long-term stability study of Prussian blue-A quality assessment of water content and cyanide release. AN - 1653130931; 25608705 AB - Prussian blue, ferric hexacyanoferrate is approved for (oral) treatment of internal contamination with radioisotopes of cesium or thallium. Cyanide makes up 35-40% of Prussian blue's molecular composition; thus, cyanide may be released during transit through the digestive tract under physiological pH conditions. The purpose of this study is to assess the long-term stability of Prussian blue drug products and active pharmaceutical ingredients and its impact on cyanide release. The study involves the determination and comparison of the loss in water content and cyanide released from Prussian blue under pH conditions that bracket human physiological exposure. Test samples of active pharmaceutical ingredient and drug product were stored for 10 years at ambient temperatures that mimic warehouse storage conditions. Water loss from Prussian blue was measured using thermogravimetric analysis. An in vitro physiological pH model that brackets gastric exposure and gastrointestinal transit was utilized for cyanide release. Prussian blue was incubated in situ at pH: 1.0, 5.0, and 7.0 @ 37°C for 1-24 h. Cyanide was measured using a validated colorimetric method by UV-Vis spectroscopy. Although the water content (quality attribute) of Prussian blue active pharmaceutical ingredient and drug product decreased by about 10.5% and 13.8%, respectively, since 2003, the cyanide release remained comparable. At pH of 7.0 for 24 h cyanide released from active pharmaceutical ingredient-1 was 21.33 ± 1.76 μg/g in 2004, and 28.45 ± 3.15 μg/g in 2013; cyanide released from drug product-1 was 21.89 ± 0.56 μg/g in 2004, and 27.31 ± 5.78 μg/g in 2013. At gastric pH of 1.0 and upper gastrointestinal pH of 5.0, the data for active pharmaceutical ingredients and drug products were also comparable in 2013. The cyanide release is still pH-dependent and follows the same trend as observed in 2003 with minimum release at pH of 5.0 and maximal release at pH of 1.0. In summary, this is the long-term stability study of Prussian blue which correlates cyanide release to water loss. Cyanide released from Prussian blue was maximum at pH of 1.0 (47.47 μg/g) and minimum at pH of 5.0-7.0 (20.01 μg/g). Based on maximal dose, maximal residence time in stomach and intestine, the maximal cyanide released from Prussian blue is about 1.31 mg, which is far below the minimal lethal dose of cyanide of 50 mg, and therefore does not present a safety concern following long-term storage. JF - Clinical toxicology (Philadelphia, Pa.) AU - Mohammad, A AU - Yang, Y AU - Khan, M A AU - Faustino, P J AD - Food and Drug Administration, Center for Drug Evaluation and Research, Division of Product Quality Research , Silver Spring, MD , USA. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 102 EP - 107 VL - 53 IS - 2 KW - Cyanides KW - 0 KW - Ferrocyanides KW - Water KW - 059QF0KO0R KW - ferric ferrocyanide KW - TLE294X33A KW - Abridged Index Medicus KW - Index Medicus KW - Prussian blue KW - Long-term stability KW - Toxicity KW - Cyanide poisoning KW - Crystallization KW - Drug Stability KW - Hydrogen-Ion Concentration KW - Reference Standards KW - Calibration KW - Quality Control KW - Water -- analysis KW - Cyanides -- analysis KW - Ferrocyanides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1653130931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+toxicology+%28Philadelphia%2C+Pa.%29&rft.atitle=Long-term+stability+study+of+Prussian+blue-A+quality+assessment+of+water+content+and+cyanide+release.&rft.au=Mohammad%2C+A%3BYang%2C+Y%3BKhan%2C+M+A%3BFaustino%2C+P+J&rft.aulast=Mohammad&rft.aufirst=A&rft.date=2015-02-01&rft.volume=53&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Clinical+toxicology+%28Philadelphia%2C+Pa.%29&rft.issn=1556-9519&rft_id=info:doi/10.3109%2F15563650.2014.998337 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-06 N1 - Date created - 2015-02-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/15563650.2014.998337 ER - TY - JOUR T1 - More than half of US youth consume seafood and most have blood mercury concentrations below the EPA reference level, 2009-2012. AN - 1652454159; 25644354 AB - Consuming seafood has health benefits, but seafood can also contain methylmercury, a neurotoxicant. Exposure to methylmercury affects children at different stages of brain development, including during adolescence. The objective was to examine seafood consumption and blood mercury concentrations in US youth. In the 2009-2012 NHANES, a cross-sectional nationally representative sample of the US population, seafood consumption in the past 30 d and blood mercury concentrations on the day of examination were collected from 5656 youth aged 1-19 y. Log-linear regression was used to examine the association between frequency of specific seafood consumption and blood mercury concentration, adjusting for race/Hispanic origin, sex, and age. In 2009-2012, 62.4% ± 1.4% (percent ± SE) of youth consumed any seafood in the preceding month; 38.4% ± 1.4% and 48.5% ± 1.5% reported consuming shellfish and fish, respectively. In 2009-2012, the geometric mean blood mercury concentration was 0.50 ± 0.02 μg/L among seafood consumers and 0.27 ± 0.01 μg/L among those who did not consume seafood. Less than 0.5% of youth had blood mercury concentrations ≥5.8 μg/L. In adjusted log-linear regression analysis, no significant associations were observed between frequency of breaded fish or catfish consumption and blood mercury concentrations, but frequency of consuming certain seafood types had significant positive association with blood mercury concentrations: high-mercury fish (swordfish and shark) [exponentiated β coefficient (expβ): 2.40; 95% CI: 1.23, 4.68]; salmon (expβ: 1.41; 95% CI: 1.26, 1.55); tuna (expβ: 1.38; 95% CI: 1.29, 1.45); crabs (expβ: 1.35; 95% CI: 1.17, 1.55); shrimp (expβ: 1.12; 95% CI: 1.05, 1.20), and all other seafood (expβ: 1.23; 95% CI: 1.17, 1.32). Age-stratified log-linear regression analyses produced similar results. Few US youth have blood mercury concentrations ≥5.8 μg/L, although more than half of US youth consumed seafood in the past month. © 2015 American Society for Nutrition. JF - The Journal of nutrition AU - Nielsen, Samara Joy AU - Aoki, Yutaka AU - Kit, Brian K AU - Ogden, Cynthia L AD - Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, CDC, Hyattsville, MD; and wjf7@cdc.gov. ; Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, CDC, Hyattsville, MD; and. ; Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, CDC, Hyattsville, MD; and US Public Health Service, Rockville, MD. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 322 EP - 327 VL - 145 IS - 2 KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - blood mercury KW - shellfish KW - seafood KW - fish KW - youth KW - United States KW - Young Adult KW - United States Environmental Protection Agency KW - Humans KW - Food Contamination -- analysis KW - Child KW - Nutrition Surveys KW - Child, Preschool KW - Risk Assessment KW - Infant KW - Cross-Sectional Studies KW - Adolescent KW - Female KW - Male KW - Nutrition Policy -- legislation & jurisprudence KW - Mercury -- blood KW - Environmental Exposure -- analysis KW - Seafood -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652454159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=More+than+half+of+US+youth+consume+seafood+and+most+have+blood+mercury+concentrations+below+the+EPA+reference+level%2C+2009-2012.&rft.au=Nielsen%2C+Samara+Joy%3BAoki%2C+Yutaka%3BKit%2C+Brian+K%3BOgden%2C+Cynthia+L&rft.aulast=Nielsen&rft.aufirst=Samara&rft.date=2015-02-01&rft.volume=145&rft.issue=2&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=1541-6100&rft_id=info:doi/10.3945%2Fjn.114.203786 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-23 N1 - Date created - 2015-02-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3945/jn.114.203786 ER - TY - JOUR T1 - Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. AN - 1652444027; 25349334 AB - One endocrine disruption mechanism is through binding to nuclear receptors such as the androgen receptor (AR) and estrogen receptor (ER) in target cells. The concentration of a chemical in serum is important for its entry into the target cells to bind the receptors, which is regulated by the serum proteins. Human sex hormone-binding globulin (SHBG) is the major transport protein in serum that can bind androgens and estrogens and thus change a chemical's availability to enter the target cells. Sequestration of an androgen or estrogen in the serum can alter the chemical elicited AR- and ER-mediated responses. To better understand the chemical-induced endocrine activity, we developed a competitive binding assay using human pregnancy plasma and measured the binding to the human SHBG for 125 structurally diverse chemicals, most of which were known to bind AR and ER. Eighty seven chemicals were able to bind the human SHBG in the assay, whereas 38 chemicals were nonbinders. Binding data for human SHBG are compared with that for rat α-fetoprotein, ER and AR. Knowing the binding profiles between serum and nuclear receptors will improve assessment of a chemical's potential for endocrine disruption. The SHBG binding data reported here represent the largest data set of structurally diverse chemicals tested for human SHBG binding. Utilization of the SHBG binding data with AR and ER binding data could enable better evaluation of endocrine disrupting potential of chemicals through AR- and ER-mediated responses since sequestration in serum could be considered. Published by Oxford University Press on behalf of the Society of Toxicology 2014. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Hong, Huixiao AU - Branham, William S AU - Ng, Hui Wen AU - Moland, Carrie L AU - Dial, Stacey L AU - Fang, Hong AU - Perkins, Roger AU - Sheehan, Daniel AU - Tong, Weida AD - *Division of Bioinformatics and Biostatistics, Division of Systems Biology, Division of Genetic and Molecular Toxicology and Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079 huixiao.hong@fda.hhs.gov. ; *Division of Bioinformatics and Biostatistics, Division of Systems Biology, Division of Genetic and Molecular Toxicology and Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 333 EP - 348 VL - 143 IS - 2 KW - Endocrine Disruptors KW - 0 KW - Ligands KW - Receptors, Androgen KW - Receptors, Estrogen KW - Sex Hormone-Binding Globulin KW - alpha-Fetoproteins KW - Index Medicus KW - sex hormone-binding globulin KW - binding affinity KW - endocrine disruptor KW - androgen receptor KW - alpha-fetoprotein KW - estrogen receptor KW - Models, Molecular KW - Humans KW - Binding, Competitive KW - Protein Binding KW - Structure-Activity Relationship KW - Sex Hormone-Binding Globulin -- chemistry KW - Endocrine Disruptors -- metabolism KW - Receptors, Androgen -- metabolism KW - alpha-Fetoproteins -- chemistry KW - Sex Hormone-Binding Globulin -- metabolism KW - Receptors, Estrogen -- chemistry KW - Receptors, Estrogen -- metabolism KW - Receptors, Androgen -- chemistry KW - alpha-Fetoproteins -- metabolism KW - Endocrine Disruptors -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652444027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Human+sex+hormone-binding+globulin+binding+affinities+of+125+structurally+diverse+chemicals+and+comparison+with+their+binding+to+androgen+receptor%2C+estrogen+receptor%2C+and+%CE%B1-fetoprotein.&rft.au=Hong%2C+Huixiao%3BBranham%2C+William+S%3BNg%2C+Hui+Wen%3BMoland%2C+Carrie+L%3BDial%2C+Stacey+L%3BFang%2C+Hong%3BPerkins%2C+Roger%3BSheehan%2C+Daniel%3BTong%2C+Weida&rft.aulast=Hong&rft.aufirst=Huixiao&rft.date=2015-02-01&rft.volume=143&rft.issue=2&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu231 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-01 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu231 ER - TY - JOUR T1 - Carbon nanotubes induce apoptosis resistance of human lung epithelial cells through FLICE-inhibitory protein. AN - 1652441335; 25412619 AB - Chronic exposure to single-walled carbon nanotubes (SWCNT) has been reported to induce apoptosis resistance of human lung epithelial cells. As resistance to apoptosis is a foundation of neoplastic transformation and cancer development, we evaluated the apoptosis resistance characteristic of the exposed lung cells to understand the pathogenesis mechanism. Passage control and SWCNT-transformed human lung epithelial cells were treated with known inducers of apoptosis via the intrinsic (antimycin A and CDDP) or extrinsic (FasL and TNF-α) pathway and analyzed for apoptosis by DNA fragmentation, annexin-V expression, and caspase activation assays. Whole-genome microarray was performed to aid the analysis of apoptotic gene signaling network. The SWCNT-transformed cells exhibited defective death receptor pathway in association with cellular FLICE-inhibitory protein (c-FLIP) overexpression. Knockdown or chemical inhibition of c-FLIP abrogated the apoptosis resistance of SWCNT-transformed cells. Whole-genome expression signature analysis confirmed these findings. This study is the first to demonstrate carbon nanotube-induced defective death receptor pathway and the role of c-FLIP in the process. Published by Oxford University Press on behalf of the Society of Toxicology 2014. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Pongrakhananon, Varisa AU - Luanpitpong, Sudjit AU - Stueckle, Todd A AU - Wang, Liying AU - Nimmannit, Ubonthip AU - Rojanasakul, Yon AD - *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand. ; *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand. ; *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand. ; *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand yrojan@hsc.wvu.edu. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 499 EP - 511 VL - 143 IS - 2 KW - CASP8 and FADD-Like Apoptosis Regulating Protein KW - 0 KW - Nanotubes, Carbon KW - Receptors, Death Domain KW - Index Medicus KW - carbon nanotubes KW - c-FLIP KW - lung KW - apoptosis KW - death receptor KW - Gene Knockdown Techniques KW - Dose-Response Relationship, Drug KW - Humans KW - Cell Culture Techniques KW - Receptors, Death Domain -- metabolism KW - Cell Line KW - CASP8 and FADD-Like Apoptosis Regulating Protein -- metabolism KW - Drug Resistance -- drug effects KW - CASP8 and FADD-Like Apoptosis Regulating Protein -- antagonists & inhibitors KW - Cell Transformation, Neoplastic -- drug effects KW - Lung -- pathology KW - Lung -- metabolism KW - Nanotubes, Carbon -- toxicity KW - Epithelial Cells -- metabolism KW - Apoptosis -- genetics KW - CASP8 and FADD-Like Apoptosis Regulating Protein -- genetics KW - Epithelial Cells -- drug effects KW - Epithelial Cells -- pathology KW - Apoptosis -- drug effects KW - Lung -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652441335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Carbon+nanotubes+induce+apoptosis+resistance+of+human+lung+epithelial+cells+through+FLICE-inhibitory+protein.&rft.au=Pongrakhananon%2C+Varisa%3BLuanpitpong%2C+Sudjit%3BStueckle%2C+Todd+A%3BWang%2C+Liying%3BNimmannit%2C+Ubonthip%3BRojanasakul%2C+Yon&rft.aulast=Pongrakhananon&rft.aufirst=Varisa&rft.date=2015-02-01&rft.volume=143&rft.issue=2&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu251 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-01 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Part Fibre Toxicol. 2014;11:3 [24405760] Part Fibre Toxicol. 2013;10(1):53 [24144386] Cell Death Differ. 2014 Mar;21(3):451-61 [24270411] Part Fibre Toxicol. 2014;11:22 [24885671] J Immunol Res. 2014;2014:149185 [24901008] Part Fibre Toxicol. 2014;11:28 [24915862] Toxicon. 2014 Sep;87:120-30 [24932741] Oncotarget. 2014 Jun 15;5(11):3541-54 [24939878] Cancer Res. 2006 Feb 15;66(4):2367-75 [16489043] Toxicol Sci. 2006 Jul;92(1):5-22 [16484287] Free Radic Biol Med. 2007 May 15;42(10):1599-609 [17448907] J Bioenerg Biomembr. 2007 Feb;39(1):43-50 [17318397] Nat Rev Mol Cell Biol. 2001 Aug;2(8):589-98 [11483992] Mol Cell Biol. 2001 Dec;21(24):8247-54 [11713262] J Am Soc Nephrol. 2002 Apr;13(4):858-65 [11912244] Mol Cell. 2002 Mar;9(3):459-70 [11931755] Apoptosis. 2002 Aug;7(4):313-9 [12101390] Int J Oncol. 2003 Jan;22(1):15-20 [12469180] Acc Chem Res. 2002 Dec;35(12):1096-104 [12484798] J Cell Biochem. 2003 Apr 1;88(5):885-98 [12616528] Nat Immunol. 2003 Apr;4(4):308-10 [12660728] Oncogene. 2004 Apr 12;23(16):2785-96 [15077142] Oncogene. 2004 Oct 14;23(47):7753-60 [15334061] Int J Cancer. 1994 May 1;57(3):371-7 [8168998] J Immunol. 1996 Jan 1;156(1):13-7 [8598453] Nature. 1997 Jul 10;388(6638):190-5 [9217161] Science. 1998 Aug 28;281(5381):1305-8 [9721089] J Cell Sci. 2005 Jan 15;118(Pt 2):265-7 [15654015] J Biochem Mol Biol. 2002 Jan 31;35(1):24-7 [16248966] Eur Respir J. 2008 Dec;32(6):1631-8 [19043009] Toxicol Lett. 2009 May 8;186(3):166-73 [19114091] Toxicology. 2010 Mar 10;269(2-3):136-47 [19857541] J Cell Mol Med. 2010 Jun;14(6B):1760-76 [19538462] Cell Death Differ. 2010 Dec;17(12):1908-16 [20508645] Nano Lett. 2011 Jul 13;11(7):2796-803 [21657258] Mutat Res. 2012 Jun 14;745(1-2):28-37 [22178868] Exp Oncol. 2012 Oct;34(3):176-84 [23070002] Toxicol Sci. 2012 Dec;130(2):298-308 [22869613] Adv Drug Deliv Rev. 2013 Dec;65(15):2078-86 [23899865] J Immunol. 2008 Mar 1;180(5):3072-80 [18292530] J Toxicol Sci. 2008 Feb;33(1):105-16 [18303189] Int J Cancer. 2008 May 15;122(10):2210-22 [18214855] Science. 2008 May 2;320(5876):674-7 [18403674] Mol Cancer Ther. 2008 May;7(5):1156-63 [18483303] Nat Nanotechnol. 2008 Jul;3(7):423-8 [18654567] Mutat Res. 2008 Jul-Aug;659(1-2):15-30 [18485806] Oncol Rep. 2008 Sep;20(3):689-93 [18695925] Cancer Res. 2008 Aug 15;68(16):6652-60 [18701489] Environ Health Perspect. 2008 Sep;116(9):1211-7 [18795165] Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L552-65 [18658273] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu251 ER - TY - JOUR T1 - FutureTox II: in vitro data and in silico models for predictive toxicology. AN - 1652440978; 25628403 AB - FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the state of the science in toxicology in the context of implementing the NRC 21st century vision of predicting in vivo responses from in vitro and in silico data, and to define the goals for the future. Presentations and discussions were held on priority concerns such as predicting and modeling of metabolism, cell growth and differentiation, effects on sensitive subpopulations, and integrating data into risk assessment. Emerging trends in technologies such as stem cell-derived human cells, 3D organotypic culture models, mathematical modeling of cellular processes and morphogenesis, adverse outcome pathway development, and high-content imaging of in vivo systems were discussed. Although advances in moving towards an in vitro/in silico based risk assessment paradigm were apparent, knowledge gaps in these areas and limitations of technologies were identified. Specific recommendations were made for future directions and research needs in the areas of hepatotoxicity, cancer prediction, developmental toxicity, and regulatory toxicology. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Knudsen, Thomas B AU - Keller, Douglas A AU - Sander, Miriam AU - Carney, Edward W AU - Doerrer, Nancy G AU - Eaton, David L AU - Fitzpatrick, Suzanne Compton AU - Hastings, Kenneth L AU - Mendrick, Donna L AU - Tice, Raymond R AU - Watkins, Paul B AU - Whelan, Maurice AD - United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy. ; United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy douglas.keller@sanofi.com. ; United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 256 EP - 267 VL - 143 IS - 2 KW - Index Medicus KW - predictive toxicology KW - in silico KW - modeling KW - in vitro KW - risk assessment KW - United States KW - Societies, Scientific KW - Predictive Value of Tests KW - Congresses as Topic KW - Computer Simulation KW - Toxicology -- trends KW - In Vitro Techniques KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652440978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=FutureTox+II%3A+in+vitro+data+and+in+silico+models+for+predictive+toxicology.&rft.au=Knudsen%2C+Thomas+B%3BKeller%2C+Douglas+A%3BSander%2C+Miriam%3BCarney%2C+Edward+W%3BDoerrer%2C+Nancy+G%3BEaton%2C+David+L%3BFitzpatrick%2C+Suzanne+Compton%3BHastings%2C+Kenneth+L%3BMendrick%2C+Donna+L%3BTice%2C+Raymond+R%3BWatkins%2C+Paul+B%3BWhelan%2C+Maurice&rft.aulast=Knudsen&rft.aufirst=Thomas&rft.date=2015-02-01&rft.volume=143&rft.issue=2&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu234 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-01 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Toxicol Chem. 2011 Jan;30(1):9-21 [20963854] Nat Biotechnol. 2014 Jun;32(6):583-91 [24837663] Toxicol Sci. 2011 Sep;123(1):281-9 [21693436] Environ Health Perspect. 2015 Mar;123(3):237-45 [25376053] Birth Defects Res C Embryo Today. 2011 Dec;93(4):312-23 [22271680] Genetics. 2012 Feb;190(2):389-401 [22345608] Toxicol Sci. 2012 Apr;126(2):291-7 [22262567] Nat Rev Cancer. 2007 Jan;7(1):54-60 [17186018] Genome Biol. 2006;7(7):R61 [16859521] Arch Intern Med. 2007 Sep 10;167(16):1752-9 [17846394] Science. 2008 Feb 15;319(5865):906-7 [18276874] Toxicol Sci. 2009 Mar;108(1):19-21 [19168570] Environ Health Perspect. 2009 Apr;117(4):624-31 [19440503] Toxicol Sci. 2009 Jul;110(1):40-6 [19435982] Toxicol Sci. 2009 Aug;110(2):251-4 [19468057] Toxicol Sci. 2009 Nov;112(1):17-22 [19703945] Toxicol Sci. 2009 Dec;112(2):297-302 [19805406] Toxicol Sci. 2010 Mar;114(1):20-4 [20026472] Toxicol Sci. 2010 Sep;117(1):17-24 [20573784] Environ Toxicol Chem. 2010 Mar;29(3):730-41 [20821501] N Engl J Med. 2010 Oct 7;363(15):1397-409 [20660394] Environ Toxicol Chem. 2011 Jan;30(1):64-76 [20963853] Toxicol Sci. 2011 Oct;123(2):349-58 [21750347] BMC Syst Biol. 2011;5:190 [22074594] Toxicol Sci. 2012 Jan;125(1):157-74 [21948869] Methods Cell Biol. 2012;110:325-66 [22482955] J Mol Cell Cardiol. 2012 May;52(5):998-1008 [22353256] J Pharmacol Exp Ther. 2012 May;341(2):510-7 [22353878] Chem Res Toxicol. 2012 Jul 16;25(7):1287-302 [22519603] Trends Biotechnol. 2012 Aug;30(8):421-5 [22652049] Environ Health Perspect. 2013 Jan;121(1):7-14 [23052129] Environ Health Perspect. 2013 Jan;121(1):23-31 [23086705] Methods Mol Biol. 2013;969:3-28 [23296924] Toxicol Sci. 2013 Apr;132(2):327-46 [23358191] Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1053-63 [23485712] Toxicol Sci. 2013 Jul;134(1):180-94 [23596260] Environ Health Perspect. 2013 Jul;121(7):756-65 [23603828] Nat Rev Drug Discov. 2013 Aug;12(8):565-7 [23903208] Science. 2013 Aug 9;341(6146):651-4 [23868920] Toxicol Appl Pharmacol. 2013 Sep 15;271(3):309-23 [20353796] Toxicology. 2013 Oct 4;312:158-65 [23978457] Chem Res Toxicol. 2013 Dec 16;26(12):1840-61 [24206190] Toxicol Sci. 2014 Feb;137(2):269-77 [24204016] Stem Cell Res Ther. 2013;4 Suppl 1:I1 [24565163] J Appl Toxicol. 2014 Jan;34(1):1-18 [24166207] Chem Res Toxicol. 2014 Mar 17;27(3):314-29 [24446777] J Chem Inf Model. 2014 Jan 27;54(1):1-4 [24251851] Chem Res Toxicol. 2011 Aug 15;24(8):1251-62 [21699217] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu234 ER - TY - JOUR T1 - The cytotoxic mechanism of karlotoxin 2 (KmTx 2) from Karlodinium veneficum (Dinophyceae). AN - 1652427671; 25546005 AB - This study demonstrates that the polyketide toxin karlotoxin 2 (KmTx 2) produced by Karlodinium veneficum, a dinoflagellate associated with fish kills in temperate estuaries world-wide, alters vertebrate cell membrane permeability. Microfluorimetric and electrophysiological measurements were used to determine that vertebrate cellular toxicity occurs through non-selective permeabilization of plasma membranes, leading to osmotic cell lysis. Previous studies showed that KmTx 2 is lethal to fish at naturally-occurring concentrations measured during fish kills, while sub-lethal doses severely damage gill epithelia. This study provides a mechanistic explanation for the association between K. veneficum blooms and fish kills that has long been observed in temperate estuaries worldwide. Published by Elsevier B.V. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Deeds, Jonathan R AU - Hoesch, Robert E AU - Place, Allen R AU - Kao, Joseph P Y AD - University of Maryland Center for Environmental Science, Institute of Marine and Environmental Technology, 701 East Pratt Street, Suite 236, Baltimore, MD 21202, USA. Electronic address: jonathan.deeds@fda.hhs.gov. ; University of Maryland, Baltimore, Center for Biomedical Engineering and Technology and Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. ; University of Maryland Center for Environmental Science, Institute of Marine and Environmental Technology, 701 East Pratt Street, Suite 236, Baltimore, MD 21202, USA. Electronic address: place@umces.edu. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 148 EP - 155 VL - 159 KW - Pyrans KW - 0 KW - Water Pollutants, Chemical KW - karlotoxin-2 KW - Index Medicus KW - Karlotoxin KW - Colloid osmotic lysis KW - Non-selective membrane permeability KW - Pore-forming toxin KW - Fish kills KW - Rats KW - Erythrocytes -- drug effects KW - Animals KW - Dinoflagellida -- physiology KW - Cell Membrane Permeability -- drug effects KW - Cell Membrane -- drug effects KW - Fishes KW - Rabbits KW - Male KW - Cell Line KW - Dinoflagellida -- chemistry KW - Pyrans -- pharmacology KW - Water Pollutants, Chemical -- pharmacology KW - Water Pollutants, Chemical -- toxicity KW - Pyrans -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652427671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=The+cytotoxic+mechanism+of+karlotoxin+2+%28KmTx+2%29+from+Karlodinium+veneficum+%28Dinophyceae%29.&rft.au=Deeds%2C+Jonathan+R%3BHoesch%2C+Robert+E%3BPlace%2C+Allen+R%3BKao%2C+Joseph+P+Y&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2015-02-01&rft.volume=159&rft.issue=&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2014.11.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-27 N1 - Date created - 2015-01-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Nat Prod. 2010 Aug 27;73(8):1360-5 [20795740] Bioorg Med Chem Lett. 2010 Apr 1;20(7):2215-8 [20207137] Methods Cell Biol. 2010;99:113-52 [21035685] J Neurophysiol. 2001 Jul;86(1):190-6 [11431501] Infect Immun. 2000 Jun;68(6):3180-5 [10816461] J Biol Chem. 1985 Mar 25;260(6):3440-50 [3838314] J Physiol. 1979 Jan;286:417-45 [312319] Pflugers Arch. 1981 Aug;391(2):85-100 [6270629] Biochimie. 1989 Jan;71(1):37-47 [2497796] Eur J Cell Biol. 1990 Apr;51(2):252-8 [1693573] Am J Physiol. 1993 Aug;265(2 Pt 2):H604-15 [8368363] J Auton Nerv Syst. 1993 Oct;45(1):29-39 [7901264] Methods Cell Biol. 1994;40:155-81 [8201975] Nat Toxins. 1998;6(1):35-41 [9851510] Biochim Biophys Acta. 2004 Nov 17;1667(1):91-100 [15533309] Bioorg Med Chem. 2008 Mar 15;16(6):3084-90 [18180163] Org Lett. 2008 Nov 20;10(22):5203-6 [18959425] J Am Chem Soc. 2010 Mar 17;132(10):3277-9 [20155901] Nat Prod Rep. 2010 Oct;27(10):1480-92 [20820637] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aquatox.2014.11.028 ER - TY - JOUR T1 - Cytotoxic mechanism of cytolethal distending toxin in nontyphoidal Salmonella serovar (Salmonella Javiana) during macrophage infection. AN - 1652425305; 25389664 AB - Cytolethal distending toxin B (cdtB) is a conserved virulence factor in Salmonella enterica serovar Typhi. Here we report the presence and functionality of cdtB in some nontyphoidal Salmonella (NTS) serovars, including Salmonella Javiana (cdtB+wt S. Javiana), isolated from imported food. To understand the role of cdtB in NTS serovars, a deletion mutant (cdtB(-)ΔS. Javiana) was constructed. Macrophages were infected with cdtB+wt S. Javiana (wild type), cdtB(-)Δ S. Javiana (mutant), and cdtB-negative NTS serovar (S. Typhimurium). Cytotoxic activity and transcription level of genes involved in cell death (apoptosis, autophagy, and necrosis) were assessed in infected macrophages. The cdtB+wt S. Javiana caused cellular distension as well as high degree of vacuolization and presence of the autophagosome marker LC3 in infected macrophages as compared with cdtB(-)ΔS. Javiana. The mRNA expression of genes involved in the induction of autophagy in response to toxin (Esr1 and Pik3C3) and coregulators of autophagy and apoptosis (Bax and Cyld) were significantly upregulated in cdtB(+)wt S. Javiana-infected macrophages. As autophagy destroys internalized pathogens in addition to the infected cell, it may reduce the spread of infection. JF - DNA and cell biology AU - Williams, Katherine AU - Gokulan, Kuppan AU - Shelman, Diamond AU - Akiyama, Tatsuya AU - Khan, Ashraf AU - Khare, Sangeeta AD - Division of Microbiology, National Center for Toxicological Research , U.S. Food and Drug Administration, Jefferson, Arkansas. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 113 EP - 124 VL - 34 IS - 2 KW - Bacterial Toxins KW - 0 KW - Estrogen Receptor alpha KW - MAP1LC3 protein, mouse KW - Microtubule-Associated Proteins KW - bcl-2-Associated X Protein KW - cytolethal distending toxin KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - CYLD protein, mouse KW - EC 3.1.2.15 KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - Index Medicus KW - Phosphatidylinositol 3-Kinases -- genetics KW - Animals KW - Autophagy -- genetics KW - Cell Survival -- genetics KW - Gene Expression KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Cell Shape -- genetics KW - Microscopy, Fluorescence KW - bcl-2-Associated X Protein -- genetics KW - Necrosis -- genetics KW - Microtubule-Associated Proteins -- genetics KW - Apoptosis -- genetics KW - Estrogen Receptor alpha -- genetics KW - Host-Pathogen Interactions -- genetics KW - Cell Line KW - Cysteine Endopeptidases -- genetics KW - Macrophages -- cytology KW - Bacterial Toxins -- genetics KW - Salmonella -- genetics KW - Salmonella -- physiology KW - Macrophages -- microbiology KW - Salmonella -- classification KW - Mutation KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652425305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+and+cell+biology&rft.atitle=Cytotoxic+mechanism+of+cytolethal+distending+toxin+in+nontyphoidal+Salmonella+serovar+%28Salmonella+Javiana%29+during+macrophage+infection.&rft.au=Williams%2C+Katherine%3BGokulan%2C+Kuppan%3BShelman%2C+Diamond%3BAkiyama%2C+Tatsuya%3BKhan%2C+Ashraf%3BKhare%2C+Sangeeta&rft.aulast=Williams&rft.aufirst=Katherine&rft.date=2015-02-01&rft.volume=34&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=DNA+and+cell+biology&rft.issn=1557-7430&rft_id=info:doi/10.1089%2Fdna.2014.2602 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-21 N1 - Date created - 2015-01-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1089/dna.2014.2602 ER - TY - JOUR T1 - Molecular and epidemiological review of toxigenic diphtheria infections in England between 2007 and 2013. AN - 1652412482; 25502525 AB - Human infections caused by toxigenic corynebacteria occur sporadically across Europe. In this report, we undertook the epidemiological and molecular characterization of all toxigenic corynebacterium strains isolated in England between January 2007 and December 2013. Epidemiological aspects include case demographics, risk factors, clinical presentation, treatment, and outcome. Molecular characterization was performed using multilocus sequence typing (MLST) alongside traditional phenotypic methods. In total, there were 20 cases of toxigenic corynebacteria; 12 (60.0%) were caused by Corynebacterium ulcerans, where animal contact was the predominant risk factor. The remaining eight (40.0%) were caused by Corynebacterium diphtheriae strains; six were biovar mitis, which were associated with recent travel abroad. Adults 45 years and older were particularly affected (55.0%; 11/20), and typical symptoms included sore throat and fever. Respiratory diphtheria with the absence of a pharyngeal membrane was the most common presentation (50.0%; 10/20). None of the eight C. diphtheriae cases were fully immunized. Diphtheria antitoxin was issued in two (9.5%) cases; both survived. Two (9.5%) cases died, one due to a C. diphtheriae infection and one due to C. ulcerans. MLST demonstrated that the majority (87.5%; 7/8) of C. diphtheriae strains represented new sequence types (STs). By adapting several primer sequences, the MLST genes in C. ulcerans were also amplified, thereby providing the basis for extension of the MLST scheme, which is currently restricted to C. diphtheriae. Despite high population immunity, occasional toxigenic corynebacterium strains are identified in England and continued surveillance is required. Copyright © 2015, American Society for Microbiology. All Rights Reserved. JF - Journal of clinical microbiology AU - Both, Leonard AU - Collins, Sarah AU - de Zoysa, Aruni AU - White, Joanne AU - Mandal, Sema AU - Efstratiou, Androulla AD - WHO Global Reference Centre for Diphtheria and Streptococcal Infections, Public Health England (PHE), London, United Kingdom. ; Immunisation, Hepatitis and Blood Safety Department, Centre for Infectious Disease Surveillance and Control, Public Health England (PHE), London, United Kingdom. ; WHO Global Reference Centre for Diphtheria and Streptococcal Infections, Public Health England (PHE), London, United Kingdom Androulla.Efstratiou@phe.gov.uk. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 567 EP - 572 VL - 53 IS - 2 KW - Diphtheria Toxin KW - 0 KW - Index Medicus KW - Young Adult KW - Animals KW - Humans KW - Aged KW - Child KW - Multilocus Sequence Typing KW - Demography KW - Aged, 80 and over KW - England -- epidemiology KW - Risk Factors KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Corynebacterium -- isolation & purification KW - Corynebacterium Infections -- drug therapy KW - Corynebacterium -- genetics KW - Corynebacterium Infections -- pathology KW - Corynebacterium -- classification KW - Diphtheria Toxin -- secretion KW - Corynebacterium Infections -- microbiology KW - Corynebacterium Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652412482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Molecular+and+epidemiological+review+of+toxigenic+diphtheria+infections+in+England+between+2007+and+2013.&rft.au=Both%2C+Leonard%3BCollins%2C+Sarah%3Bde+Zoysa%2C+Aruni%3BWhite%2C+Joanne%3BMandal%2C+Sema%3BEfstratiou%2C+Androulla&rft.aulast=Both&rft.aufirst=Leonard&rft.date=2015-02-01&rft.volume=53&rft.issue=2&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=1098-660X&rft_id=info:doi/10.1128%2FJCM.03398-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-22 N1 - Date created - 2015-01-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Euro Surveill. 2014;19(24). pii: 20830 [24970373] Vaccine. 2012 Nov 19;30(49):7111-7 [23022148] J Infect Dis. 2000 Feb;181 Suppl 1:S116-20 [10657202] J Infect Dis. 2000 Feb;181 Suppl 1:S168-77 [10657209] Epidemiol Infect. 2000 Aug;125(1):113-25 [11057967] J Clin Microbiol. 1997 Feb;35(2):495-8 [9003626] Vet Res. 2006 Mar-Apr;37(2):201-18 [16472520] J Clin Microbiol. 2006 May;44(5):1625-9 [16672385] J Clin Microbiol. 2008 Nov;46(11):3626-35 [18784317] Epidemiol Infect. 2010 Nov;138(11):1519-30 [20696088] Clin Microbiol Infect. 2011 Apr;17(4):519-25 [20491827] J Clin Microbiol. 2011 Jul;49(7):2664-6 [21525220] Emerg Infect Dis. 2012 Feb;18(2):217-25 [22304732] Epidemiol Infect. 2012 Apr;140(4):617-20 [21669023] Infection. 2012 Oct;40(5):575-8 [22403045] J Clin Microbiol. 2010 Nov;48(11):4177-85 [20844217] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/JCM.03398-14 ER - TY - JOUR T1 - Functional analysis of dengue virus (DENV) type 2 envelope protein domain 3 type-specific and DENV complex-reactive critical epitope residues. AN - 1652408412; 25351518 AB - The dengue virus (DENV) envelope protein domain 3 (ED3) is the target of potent virus neutralizing antibodies. The DENV-2 ED3 contains adjacent type-specific and DENV complex-reactive antigenic sites that are composed of a small number of residues that were previously demonstrated to be critical for antibody binding. Site-directed mutagenesis of a DENV-2 16681 infectious clone was used to mutate critical residues in the DENV-2 type-specific (K305A and P384A) and DENV complex-reactive (K310A) antigenic sites. The K305A mutant virus multiplied like the parent virus in mosquito and mammalian cells, as did the P384A mutant virus, which required a compensatory mutation (G330D) for viability. However, the K310A mutant virus could not be recovered. The DENV-2 type-specific critical residue mutations K305A and P384A+G330D reduced the ability of DENV-2 type-specific, but not DENV complex-reactive, mAbs to neutralize virus infectivity and this was directly correlated with mAb binding affinity to the rED3 mutants. © 2015 The Authors. JF - The Journal of general virology AU - Pitcher, Trevor J AU - Sarathy, Vanessa V AU - Matsui, Kiyohiko AU - Gromowski, Gregory D AU - Huang, Claire Y-H AU - Barrett, Alan D T AD - Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0436, USA. ; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Fort Collins, CO 80521, USA. ; Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0436, USA abarrett@utmb.edu. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 288 EP - 293 VL - 96 KW - Antibodies, Neutralizing KW - 0 KW - Antibodies, Viral KW - Epitopes KW - Viral Envelope Proteins KW - Index Medicus KW - Virus Replication KW - Mutagenesis, Site-Directed KW - Microbial Viability KW - Models, Molecular KW - DNA Mutational Analysis KW - Antibodies, Neutralizing -- immunology KW - Antibodies, Viral -- immunology KW - Protein Conformation KW - Viral Envelope Proteins -- immunology KW - Epitopes -- genetics KW - Dengue Virus -- immunology KW - Dengue Virus -- genetics KW - Epitopes -- immunology KW - Viral Envelope Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652408412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+general+virology&rft.atitle=Functional+analysis+of+dengue+virus+%28DENV%29+type+2+envelope+protein+domain+3+type-specific+and+DENV+complex-reactive+critical+epitope+residues.&rft.au=Pitcher%2C+Trevor+J%3BSarathy%2C+Vanessa+V%3BMatsui%2C+Kiyohiko%3BGromowski%2C+Gregory+D%3BHuang%2C+Claire+Y-H%3BBarrett%2C+Alan+D+T&rft.aulast=Pitcher&rft.aufirst=Trevor&rft.date=2015-02-01&rft.volume=96&rft.issue=&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+general+virology&rft.issn=1465-2099&rft_id=info:doi/10.1099%2Fvir.0.070813-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-30 N1 - Date created - 2015-01-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Virol. 2010 Sep;84(18):9227-39 [20592088] Virology. 2010 Jan 20;396(2):305-15 [19913272] EMBO Mol Med. 2014 Mar;6(3):358-71 [24421336] Virology. 2010 Nov 25;407(2):237-46 [20832836] Virology. 2012 Jan 20;422(2):386-92 [22153298] Structure. 2012 Feb 8;20(2):303-14 [22285214] J Virol. 2012 Apr;86(7):4019-23 [22278250] J Infect Dis. 2013 Jun 15;207(12):1898-908 [23526830] Virology. 2013 Jul 5;441(2):114-25 [23571092] Cell. 2002 Mar 8;108(5):717-25 [11893341] Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91 [12759475] J Virol. 2004 Jan;78(1):378-88 [14671119] Annu Rev Microbiol. 1990;44:649-88 [2174669] Virology. 1996 Oct 15;224(2):437-45 [8874504] Virology. 1997 Apr 14;230(2):300-8 [9143286] Nat Med. 1997 Aug;3(8):866-71 [9256277] Virology. 1998 Jul 5;246(2):317-28 [9657950] Virology. 2007 Sep 30;366(2):349-60 [17719070] J Virol. 2007 Dec;81(23):12816-26 [17881453] Expert Rev Mol Med. 2008;10:e12 [18471342] J Virol. 2008 Sep;82(17):8828-37 [18562544] Cell Host Microbe. 2008 Sep 11;4(3):229-38 [18779049] Virology. 2010 Oct 25;406(2):328-35 [20708768] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1099/vir.0.070813-0 ER - TY - JOUR T1 - Cell streak imaging cytometry for rare cell detection AN - 1647003823; 21284949 AB - Detection of rare cells, such as circulating tumor cells, have many clinical applications. To measure rare cells with increased sensitivity and improved data managements, we developed an imaging flow cytometer with a streak imaging mode capability. The new streak mode imaging mode utilizes low speed video to capture moving fluorescently labeled cells in a flow cell. Each moving cell is imaged on multiple pixels on each frame, where the cell path is marked as a streak line proportional to the length of the exposure. Finding rare cells (e.g., <1 cell/mL) requires measuring larger sample volumes to achieve higher sensitivity, therefore we combined streak mode imaging with a "wide" high throughput flow cell (e.g. flow rates set to 10mL/min) in contrast to the conventional "narrow" hydrodynamic focusing cells typically used in cytometry that are inherently limited to low flow rates. The new flow cell is capable of analyzing 20mL/min of fluorescently labeled cells. To further increase sensitivity, the signal to noise ratio of the images was also enhanced by combining three imaging methods: (1) background subtraction, (2) pixel binning, and (3) CMOS color channel selection. The streaking mode cytometer has been used for the analysis of SYTO-9 labeled THP-1 human monocytes in buffer and in blood. Samples of cells at 1 cell/mL and 0.1 cell/mL were analyzed in 30mL with flow rates set to 10mL/min and frame rates of 4fps (frame per second). For the target of 1 cell/mL, an average concentration of 0.91 cell/mL was measured by cytometry, with a standard error of 0.03 (C 95=0.85-0.97). For the target of 0.1 cell/mL, an average concentration of 0.083 cell/mL was measured, with a standard error of 0.01 (C 95=0.065-0.102). Whole blood was also spiked with SYTO-9 labeled cells to a concentration of 10 cell/mL, and the average flow cytometry measurement was 8.7 cells/mL (i.e. 0.87 cells/mL in diluted blood) with a 95% CL of 8.1-9.2 cells/mL. This demonstrated the ability to detect rare cells in blood with high accuracy. Such detection approaches for rare cells have many potential clinical applications. Furthermore, the simplicity and low cost of this device may enable expansion of cell-based clinical diagnostics, especially in resource-poor settings. JF - Biosensors and Bioelectronics AU - Balsam, Joshua AU - Bruck, Hugh Alan AU - Rasooly, Avraham AD - Division of Biology, Office of Science and Engineering, FDA, Silver Spring, MD 20993, United States Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 154 EP - 160 PB - Elsevier B.V., 660 White Plains Rd. Tarrytown NY 10591-5153 United States VL - 64 SN - 0956-5663, 0956-5663 KW - Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Wide-field imaging KW - Rare cells KW - Resource-poor settings KW - Image enhancement KW - mHealth KW - Data processing KW - Hydrodynamics KW - Therapeutic applications KW - Streak KW - imaging KW - Tumor cells KW - Cytometry KW - Color KW - Biosensors KW - Blood KW - Monocytes KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647003823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=Cell+streak+imaging+cytometry+for+rare+cell+detection&rft.au=Balsam%2C+Joshua%3BBruck%2C+Hugh+Alan%3BRasooly%2C+Avraham&rft.aulast=Balsam&rft.aufirst=Joshua&rft.date=2015-02-01&rft.volume=64&rft.issue=&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2014.08.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Biosensors; Flow cytometry; Blood; Data processing; Hydrodynamics; Therapeutic applications; Monocytes; Streak; Tumor cells; imaging; Cytometry; Color DO - http://dx.doi.org/10.1016/j.bios.2014.08.065 ER - TY - JOUR T1 - An analysis of legal warnings after drug approval in Thailand. AN - 1640689128; 25445000 AB - Drug risk management has many tools for minimizing risk and black-boxed warnings (BBWs) are one of those tools. Some serious adverse drug reactions (ADRs) emerge only after a drug is marketed and used in a larger population. In Thailand, additional legal warnings after drug approval, in the form of black-boxed warnings, may be applied. Review of their characteristics can assist in the development of effective risk mitigation. This study was a cross sectional review of all legal warnings imposed in Thailand after drug approval (2003-2012). Any boxed warnings for biological products and revised warnings which were not related to safety were excluded. Nine legal warnings were evaluated. Seven related to drugs classes and two to individual drugs. The warnings involved four main types of predictable ADRs: drug-disease interactions, side effects, overdose and drug-drug interactions. The average time from first ADRs reported to legal warnings implementation was 12 years. The triggers were from both safety signals in Thailand and regulatory measures in other countries outside Thailand. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Sriphiromya, Pakawadee AU - Theeraroungchaisri, Anuchai AD - Health Product Vigilance Center, Food and Drug Administration, Ministry of Public Health, Thailand; Chulalongkorn University, Phayathai Road, Bangkok, Thailand. Electronic address: pspakawadee@gmail.com. ; Chulalongkorn University, Phayathai Road, Bangkok, Thailand. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 108 EP - 113 VL - 71 IS - 1 KW - Index Medicus KW - Legal warnings KW - Pharmacovigilance KW - Drug risk management KW - Drug safety KW - Adverse drug reactions KW - Drug Interactions KW - Government Regulation KW - Thailand KW - Drug Approval KW - Drug Overdose KW - Federal Government KW - Drug-Related Side Effects and Adverse Reactions KW - Product Surveillance, Postmarketing KW - Drug Labeling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1640689128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=An+analysis+of+legal+warnings+after+drug+approval+in+Thailand.&rft.au=Sriphiromya%2C+Pakawadee%3BTheeraroungchaisri%2C+Anuchai&rft.aulast=Sriphiromya&rft.aufirst=Pakawadee&rft.date=2015-02-01&rft.volume=71&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.10.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-02 N1 - Date created - 2014-12-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.10.013 ER - TY - JOUR T1 - Determination of Neurotoxic Acetogenins in Pawpaw (Asimina triloba) Fruit by LC-HRMS. AN - 1826609368; 25594104 AB - The concentrations of the neurotoxins, annonacin and squamocin, were determined in a lyophilized sample of the fruit pulp of the North American pawpaw (Asimina triloba) by LC coupled to high resolution mass spectrometry or LC-HRMS. The sample was extracted using dry methanol at 100 °C and 10 MPa pressure in a sealed container. The extraction of annonacin and squamocin was optimal at 100 °C with 7.72 and 0.162 mg/g, respectively, being found. Also, several isomers of annonacin and squamocin were separated and detected but not quantified. JF - Journal of agricultural and food chemistry AU - Levine, Robert A AU - Richards, Kristy M AU - Tran, Kevin AU - Luo, Rensheng AU - Thomas, Andrew L AU - Smith, Robert E AD - U.S. Food and Drug Administration, Total Diet and Pesticide Research Center, 11510 West 80th Street, Lenexa, Kansas 66214, United States. Y1 - 2015/01/22/ PY - 2015 DA - 2015 Jan 22 KW - pawpaw KW - Parkinson’s disease KW - LC-HRMS KW - squamocin KW - annonacin KW - Asimina triloba UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826609368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Determination+of+Neurotoxic+Acetogenins+in+Pawpaw+%28Asimina+triloba%29+Fruit+by+LC-HRMS.&rft.au=Levine%2C+Robert+A%3BRichards%2C+Kristy+M%3BTran%2C+Kevin%3BLuo%2C+Rensheng%3BThomas%2C+Andrew+L%3BSmith%2C+Robert+E&rft.aulast=Levine&rft.aufirst=Robert&rft.date=2015-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2015-01-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Repeated Dose 90-Day Feeding Study of Whole Fruits of Genetically Modified Papaya Resistant to Papaya Ringspot Virus in Rats. AN - 1826608918; 25578800 AB - Genetically modified (GM) papaya plants resistant to infection by Papaya ringspot virus (PRSV) have been successfully generated by cloning the coat protein (CP) gene of PRSV to increase fruit production. In this study, the GM papaya line 823-2210 was used to conduct a 90-day feeding toxicity study and compared to its parent plant of non-GM papaya, Tainung-2 (TN-2) based on the experimental guidance reported by the European Food Safety Authority.1 Ten male and 10 female Sprague-Dawley albino rats were gavaged at low (1 g/kg bw) and high (2 g/kg bw) doses of non-GM and GM lyophilized papaya fruits for 90 days. Hematology, coagulation, biochemistry, urinalysis, and pathology were examined in all animals. Although some differences were found in feed consumption, hematology, and serum chemistry examinations between non-GM and GM papaya, the results were within historical control values and not considered biologically significant in rats. In addition, there were no treatment-related gross or microscopic lesions in male or female rats attributable to the non-GM or GM papaya fruit. This 90-day feeding study of GM papaya fruit did not reveal adverse effects in rats and indicates that GM papaya fruits may be substantially equivalent to their non-GM parent plants. JF - Journal of agricultural and food chemistry AU - Lin, Hsin-Tang AU - Yen, Gow-Chin AU - Lee, Wei-Cheng AU - Tsai, Yi-Ting AU - Wu, Jhaol-Huei AU - Yeh, Shyi-Dong AU - Cheng, Ying-Huey AU - Chang, Shih-Chieh AU - Liao, Jiunn-Wang AD - Food and Drug Administration, Ministry of Health and Welfare , Taipei 115, Taiwan, Republic of China. Y1 - 2015/01/21/ PY - 2015 DA - 2015 Jan 21 KW - genetically modified KW - papaya KW - PRSV KW - subchronic feeding toxicity KW - rats UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826608918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Repeated+Dose+90-Day+Feeding+Study+of+Whole+Fruits+of+Genetically+Modified+Papaya+Resistant+to+Papaya+Ringspot+Virus+in+Rats.&rft.au=Lin%2C+Hsin-Tang%3BYen%2C+Gow-Chin%3BLee%2C+Wei-Cheng%3BTsai%2C+Yi-Ting%3BWu%2C+Jhaol-Huei%3BYeh%2C+Shyi-Dong%3BCheng%2C+Ying-Huey%3BChang%2C+Shih-Chieh%3BLiao%2C+Jiunn-Wang&rft.aulast=Lin&rft.aufirst=Hsin-Tang&rft.date=2015-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2015-01-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Cluster III of low-density lipoprotein receptor-related protein 1 binds activated blood coagulation factor VIII. AN - 1652394606; 25486042 AB - Low-density lipoprotein receptor-related protein 1 (LRP) mediates clearance of blood coagulation factor VIII (FVIII). In LRP, FVIII binds the complement-type repeats (CRs) of clusters II and IV, which also bind a majority of other LRP ligands. No ligand is known for LRP cluster I, and only three ligands, including the LRP chaperone alpha-2 macroglobulin receptor-associated protein (RAP), bind cluster III. Using surface plasmon resonance, we found that in addition to clusters II and IV, activated FVIII (FVIIIa) binds cluster III. The specificity of this interaction was confirmed using an anti-FVIII antibody fragment, which inhibited the binding. Recombinant fragments of cluster III and its site-directed mutagenesis were used to localize the cluster's site for binding FVIIIa to CR.14-19. The interactive site of FVIIIa was localized within its A1/A3'-C1-C2 heterodimer (HDa), which is a major physiological remnant of FVIIIa. In mice, the clearance of HDa was faster than that of FVIII and prolonged in the presence of RAP, which is known to inhibit interactions of LRP with its ligands. In accordance with this, the cluster III site for RAP (CR.15-19) was found to overlap that for FVIIIa. Altogether, our findings support the involvement of LRP in FVIIIa catabolism and suggest a greater significance of the biological role of cluster III compared to that previously known. JF - Biochemistry AU - Kurasawa, James H AU - Shestopal, Svetlana A AU - Woodle, Samuel A AU - Ovanesov, Mikhail V AU - Lee, Timothy K AU - Sarafanov, Andrey G AD - Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, Maryland 20993-0002, United States. Y1 - 2015/01/20/ PY - 2015 DA - 2015 Jan 20 SP - 481 EP - 489 VL - 54 IS - 2 KW - LDL-Receptor Related Protein-Associated Protein KW - 0 KW - Low Density Lipoprotein Receptor-Related Protein-1 KW - Recombinant Proteins KW - Factor VIIIa KW - 72175-66-7 KW - Factor VIII KW - 9001-27-8 KW - Index Medicus KW - LDL-Receptor Related Protein-Associated Protein -- metabolism KW - Factor VIII -- metabolism KW - Animals KW - Protein Interaction Mapping KW - Recombinant Proteins -- metabolism KW - Mice KW - Recombinant Proteins -- chemistry KW - Mice, Inbred BALB C KW - Protein Multimerization KW - Protein Binding KW - Factor VIII -- chemistry KW - Binding Sites KW - Low Density Lipoprotein Receptor-Related Protein-1 -- metabolism KW - Low Density Lipoprotein Receptor-Related Protein-1 -- chemistry KW - Factor VIIIa -- chemistry KW - Factor VIIIa -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652394606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Cluster+III+of+low-density+lipoprotein+receptor-related+protein+1+binds+activated+blood+coagulation+factor+VIII.&rft.au=Kurasawa%2C+James+H%3BShestopal%2C+Svetlana+A%3BWoodle%2C+Samuel+A%3BOvanesov%2C+Mikhail+V%3BLee%2C+Timothy+K%3BSarafanov%2C+Andrey+G&rft.aulast=Kurasawa&rft.aufirst=James&rft.date=2015-01-20&rft.volume=54&rft.issue=2&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=1520-4995&rft_id=info:doi/10.1021%2Fbi5011688 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-08 N1 - Date created - 2015-01-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/bi5011688 ER - TY - RPRT T1 - PROPOSED RULE: STANDARDS FOR GROWING, HARVESTING, PACKING, AND HOLDING OF PRODUCE FOR HUMAN CONSUMPTION. AN - 16393956; 16384 AB - PURPOSE: The Food Safety Modernization Act of 2011 (FSMA) directs FDA to build a new food safety system based on the public health principle of comprehensive prevention, an enhanced focus on risk-based resource allocation, and partnership across the public and private sectors to minimize food and feed hazards from farm to table. As such, FSMA gives FDA the public health mandate to establish standards for the adoption of modern food safety prevention practices by those who grow, process, transport, and store food. Through FSMA, FDA has proposed seven rules for stakeholders (food producers, suppliers, distributors) to follow in the supply chain that would protect public health by promoting safe, sanitary standards that, when implemented, would minimize or prevent food safety hazards. One of the Proposed Rules: Standards for Growing, Harvesting, Packing, and Holding of Produce for Human Consumption (Produce Safety Proposed Rule or PS PR) is the subject of this Draft Environmental Impact Statement (EIS). The purpose of proposing this rule is to minimize the risk of serious adverse health consequences or death, including those actions reasonably necessary to prevent the introduction of known or reasonably foreseeable biological hazards into or onto produce and to provide reasonable assurances that the produce is not adulterated on account of such hazards. FDA announced its intent to prepare an EIS and began the EIS scoping period in August 2013. This EIS, prepared in accordance with the National Environmental Policy Act and developed by the FDA in cooperation with the U.S. Department of Agriculture, assesses the environmental (including human) and related socioeconomic impacts based on potentially significant provisions of the PS PR, and alternatives to the provisions that were considered. The No Action Alternative is also assessed in this EIS as a basis for comparison, to determine the environmental impacts associated with existing conditions (current practices, laws, and procedures) if the PS PR were not implemented. JF - EPA number: 150004, Draft EIS, January 16, 2015 Y1 - 2015/01/16/ PY - 2015 DA - 2015 Jan 16 KW - Hazardous Substances KW - Public Health KW - Health Hazards KW - Farm Management KW - Water Quality KW - Fertilizers KW - Farmlands KW - Livestock KW - Grazing KW - Water Resources KW - Environmental Justice KW - Socioeconomic Assessments KW - Water Treatment KW - Irrigation KW - Soils KW - Waste Disposal KW - Air Quality KW - Harvest KW - Land Use KW - Vegetation KW - Wetlands KW - United States KW - Clean Air Act Amendments of 1990, Emission Standards KW - Executive Order 12898, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16393956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2015-01-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=PROPOSED+RULE%3A+STANDARDS+FOR+GROWING%2C+HARVESTING%2C+PACKING%2C+AND+HOLDING+OF+PRODUCE+FOR+HUMAN+CONSUMPTION.&rft.title=PROPOSED+RULE%3A+STANDARDS+FOR+GROWING%2C+HARVESTING%2C+PACKING%2C+AND+HOLDING+OF+PRODUCE+FOR+HUMAN+CONSUMPTION.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, Food and Drug Administration, College Park, Maryland N1 - Date revised - 2016-02-25 N1 - SuppNotes - Draft. Preparation date: January 16, 2015 N1 - Last updated - 2016-02-26 ER - TY - JOUR T1 - A novel family 19 chitinase from the marine-derived Pseudoalteromonas tunicata CCUG 44952T: Heterologous expression, characterization and antifungal activity AN - 1660404175; PQ0001069068 AB - The Ptchi19 gene of the marine Pseudoalteromonas tunicata CCUG 44952T was cloned and expressed in Escherichia coli. The recombinant chitinase PtChi19p of 483 amino acids has a molecular weight of 53.5 kDa and a multi-domain structure characteristic of family 19 chitinases. The relevant constituents of this multi-domain structure are the domain (D super(132)-A super(155)) where the active site is located, and the domain (A super(437)-W super(479)) that includes a C-terminal carbohydrate-binding module 5. The purified protein was active in the temperature range of 20-50 degree C and at pH values of 6-9.5, maintaining a high stability under suboptimal conditions and in the presence of different metal ions. The recombinant enzyme hydrolyzed colloidal and crystalline chitin, as well as p-NP N-acetyl- beta -d-glucosaminide. As PtChi19p exhibited antifungal activity against phytopathogenic and human pathogenic fungi, it could be used as an alternative biofungicide. JF - Biochemical Engineering Journal AU - Garcia-Fraga, Belen AU - Silva, Abigail Fda AU - Lopez-Seijas, Jacobo AU - Sieiro, Carmen Y1 - 2015/01/15/ PY - 2015 DA - 2015 Jan 15 SP - 84 EP - 93 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 93 SN - 1369-703X, 1369-703X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA Marine Biotechnology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Pseudoalteromonas tunicata KW - Family 19 glycosyl hydrolase KW - Enzyme biocatalysis KW - Recombinant DNA KW - Purification KW - Enzyme activity KW - Temperature effects KW - Metals KW - Ions KW - Chitinase KW - Amino acids KW - Fungi KW - Chitin KW - Enzymes KW - Molecular weight KW - Antifungal activity KW - Escherichia coli KW - pH effects KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03330:Biochemistry KW - Q4 27760:Microorganisms KW - J 02420:Plant Diseases KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660404175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Engineering+Journal&rft.atitle=A+novel+family+19+chitinase+from+the+marine-derived+Pseudoalteromonas+tunicata+CCUG+44952T%3A+Heterologous+expression%2C+characterization+and+antifungal+activity&rft.au=Garcia-Fraga%2C+Belen%3BSilva%2C+Abigail+Fda%3BLopez-Seijas%2C+Jacobo%3BSieiro%2C+Carmen&rft.aulast=Garcia-Fraga&rft.aufirst=Belen&rft.date=2015-01-15&rft.volume=93&rft.issue=&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Biochemical+Engineering+Journal&rft.issn=1369703X&rft_id=info:doi/10.1016%2Fj.bej.2014.09.014 L2 - http://www.sciencedirect.com/science/article/pii/S1369703X14002836 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-06-22 N1 - SubjectsTermNotLitGenreText - Temperature effects; Ions; Metals; Amino acids; Chitinase; Fungi; Molecular weight; Antifungal activity; Chitin; Enzymes; pH effects; Pseudoalteromonas tunicata; Escherichia coli DO - http://dx.doi.org/10.1016/j.bej.2014.09.014 ER - TY - JOUR T1 - Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells. AN - 1652396527; 25586472 AB - Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell lymphomas (n=51), γδ-T-cell lymphomas (n=43) and their cell lines (n=9) through next generation and/or Sanger sequencing. STAT5B N642H is particularly frequent in all forms of γδ-T-cell lymphomas. STAT3 and STAT5B mutations are associated with increased phosphorylated protein and a growth advantage to transduced cell lines or normal NK cells. Growth-promoting activity of the mutants can be partially inhibited by a JAK1/2 inhibitor. Molecular modelling and surface plasmon resonance measurements of the N642H mutant indicate a marked increase in binding affinity of the phosphotyrosine-Y699 with the mutant histidine. This is associated with the prolonged persistence of the mutant phosphoSTAT5B and marked increase of binding to target sites. Our findings suggest that JAK-STAT pathway inhibition may represent a therapeutic strategy. JF - Nature communications AU - Küçük, Can AU - Jiang, Bei AU - Hu, Xiaozhou AU - Zhang, Wenyan AU - Chan, John K C AU - Xiao, Wenming AU - Lack, Nathan AU - Alkan, Can AU - Williams, John C AU - Avery, Kendra N AU - Kavak, Pınar AU - Scuto, Anna AU - Sen, Emel AU - Gaulard, Philippe AU - Staudt, Lou AU - Iqbal, Javeed AU - Zhang, Weiwei AU - Cornish, Adam AU - Gong, Qiang AU - Yang, Qunpei AU - Sun, Hong AU - d'Amore, Francesco AU - Leppä, Sirpa AU - Liu, Weiping AU - Fu, Kai AU - de Leval, Laurence AU - McKeithan, Timothy AU - Chan, Wing C AD - Department of Pathology, City of Hope Medical Center, Duarte, California 91010, USA. ; Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, China. ; Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration, Maryland 20993, USA. ; Department of Pharmacology, Koc University, Istanbul 34450, Turkey. ; Department of Computer Engineering, Bilkent University, Ankara 06800, Turkey. ; Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California 91010, USA. ; Department of Computer Engineering, Boğaziçi University, İstanbul 34342, Turkey. ; Département de Pathologie, Groupe Henri-Mondor Albert-Chenevier, Inserm U955, Université Paris Est, Créteil 94000, France. ; Molecular Biology of Lymphoid Malignancies Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. ; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA. ; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198-5805, USA. ; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China. ; Department of Hematology, Aarhus University Hospital, Aarhus 8000, Denmark. ; Department of Oncology, Helsinki University Central Hospital, PO Box 180, Helsinki 00029, Finland. ; Pathologie Clinique Institut, Universitaire de Pathologie rue du Bugnon 25, CH 1011 Lausanne, Switzerland. Y1 - 2015/01/14/ PY - 2015 DA - 2015 Jan 14 SP - 6025 VL - 6 KW - IL2 protein, human KW - 0 KW - Interleukin-2 KW - Receptors, Antigen, T-Cell, gamma-delta KW - STAT3 Transcription Factor KW - STAT3 protein, human KW - STAT5 Transcription Factor KW - STAT5B protein, human KW - Phosphotyrosine KW - 21820-51-9 KW - Histidine KW - 4QD397987E KW - JAK1 protein, human KW - EC 2.7.10.2 KW - Janus Kinase 1 KW - Index Medicus KW - Histidine -- chemistry KW - Janus Kinase 1 -- metabolism KW - Interleukin-2 -- metabolism KW - Phosphotyrosine -- chemistry KW - Humans KW - HEK293 Cells KW - Receptors, Antigen, T-Cell, gamma-delta -- metabolism KW - Protein Structure, Tertiary KW - Mutation KW - Binding Sites KW - T-Lymphocyte Subsets -- cytology KW - Gene Expression Regulation, Neoplastic KW - STAT5 Transcription Factor -- genetics KW - STAT3 Transcription Factor -- genetics KW - Killer Cells, Natural -- cytology KW - Lymphoma, T-Cell -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652396527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+communications&rft.atitle=Activating+mutations+of+STAT5B+and+STAT3+in+lymphomas+derived+from+%CE%B3%CE%B4-T+or+NK+cells.&rft.au=K%C3%BC%C3%A7%C3%BCk%2C+Can%3BJiang%2C+Bei%3BHu%2C+Xiaozhou%3BZhang%2C+Wenyan%3BChan%2C+John+K+C%3BXiao%2C+Wenming%3BLack%2C+Nathan%3BAlkan%2C+Can%3BWilliams%2C+John+C%3BAvery%2C+Kendra+N%3BKavak%2C+P%C4%B1nar%3BScuto%2C+Anna%3BSen%2C+Emel%3BGaulard%2C+Philippe%3BStaudt%2C+Lou%3BIqbal%2C+Javeed%3BZhang%2C+Weiwei%3BCornish%2C+Adam%3BGong%2C+Qiang%3BYang%2C+Qunpei%3BSun%2C+Hong%3Bd%27Amore%2C+Francesco%3BLepp%C3%A4%2C+Sirpa%3BLiu%2C+Weiping%3BFu%2C+Kai%3Bde+Leval%2C+Laurence%3BMcKeithan%2C+Timothy%3BChan%2C+Wing+C&rft.aulast=K%C3%BC%C3%A7%C3%BCk&rft.aufirst=Can&rft.date=2015-01-14&rft.volume=6&rft.issue=&rft.spage=6025&rft.isbn=&rft.btitle=&rft.title=Nature+communications&rft.issn=2041-1723&rft_id=info:doi/10.1038%2Fncomms7025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-08 N1 - Date created - 2015-01-14 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - SRA200820; SRA N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/ncomms7025 ER - TY - JOUR T1 - The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol. AN - 1652388556; 25594250 AB - Isoflavones are found in leguminous plants, especially soybeans. They have a structural similarity to natural estrogens, which enables them to bind to estrogen receptors and elicit biological activities similar to natural estrogens. They have been suggested to be beneficial for the prevention and therapy of hormone-dependent diseases. After soy products are consumed, the bacteria of the intestinal microflora metabolize isoflavones to metabolites with altered absorption, bioavailability, and estrogenic characteristics. Variations in the effect of soy products have been correlated with the isoflavone metabolites found in plasma and urine samples of the individuals consuming soy products. The beneficial effects of the soy isoflavone daidzin, the glycoside of daidzein, have been reported in individuals producing equol, a reduction product of daidzein produced by specific colonic bacteria in individuals called equol producers. These individuals comprise 30% and 60% of populations consuming Western and soy-rich Asian diets, respectively. Since the higher percentage of equol producers in populations consuming soy-rich diets is correlated with a lower incidence of hormone-dependent diseases, considerable efforts have been made to detect the specific colonic bacteria involved in the metabolism of daidzein to the more estrogenic compound, equol, which should facilitate the investigation of the metabolic activities related to this compound. JF - Metabolites AU - Rafii, Fatemeh AD - Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Fatemeh.Rafii@fda.hhs.gov. Y1 - 2015/01/14/ PY - 2015 DA - 2015 Jan 14 SP - 56 EP - 73 VL - 5 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652388556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolites&rft.atitle=The+role+of+colonic+bacteria+in+the+metabolism+of+the+natural+isoflavone+daidzin+to+equol.&rft.au=Rafii%2C+Fatemeh&rft.aulast=Rafii&rft.aufirst=Fatemeh&rft.date=2015-01-14&rft.volume=5&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Metabolites&rft.issn=&rft_id=info:doi/10.3390%2Fmetabo5010056 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-17 N1 - Date created - 2015-01-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3390/metabo5010056 ER - TY - JOUR T1 - Aptamer-Based Detection of Disease Biomarkers in Mouse Models for Chagas Drug Discovery AN - 1660391667; PQ0001041743 AB - Drug discovery initiatives, aimed at Chagas treatment, have been hampered by the lack of standardized drug screening protocols and the absence of simple pre-clinical assays to evaluate treatment efficacy in animal models. In this study, we used a simple Enzyme Linked Aptamer (ELA) assay to detect T. cruzi biomarker in blood and validate murine drug discovery models of Chagas disease. In two mice models, Apt-29 ELA assay demonstrated that biomarker levels were significantly higher in the infected group compared to the control group, and upon Benznidazole treatment, their levels reduced. However, biomarker levels in the infected treated group did not reduce to those seen in the non-infected treated group, with 100% of the mice above the assay cutoff, suggesting that parasitemia was reduced but cure was not achieved. The ELA assay was capable of detecting circulating biomarkers in mice infected with various strains of T. cruzi parasites. Our results showed that the ELA assay could detect residual parasitemia in treated mice by providing an overall picture of the infection in the host. They suggest that the ELA assay can be used in drug discovery applications to assess treatment efficacy in-vivo. A marked decrease in incidence of Chagas Disease has been observed in the last decade achieved by vector control strategies; however, there are still geographical areas where the disease reaches endemic proportions. Due to high morbidity and disease burden, other avenues of Chagas control, such as vaccines and therapeutic agents need to be employed for comprehensive disease control and mitigation. As there are no vaccines available currently, two drugs (Benznidazole and Nifurtimox) have been the mainstay of treatment. However, these drugs produce multiple side effects and frequently lead to early termination of the treatment. In this study, we have successfully developed a new method to evaluate the presence of Chagas biomarkers in the plasma of infected drug treated mice. Our study shows that high biomarker levels in T. cruzi infected mice, after drug treatment, can indicate treatment failure. Our assay provides a global picture of parasitemia in the host and a positive result would thus suggest that the treated animals continue to harbor T. cruzi parasites somewhere in the body. This study provides a new method to test for T. cruzi infection and for assessing the effectiveness of treatment. JF - PLoS Neglected Tropical Diseases AU - de Araujo, Fernanda Fortes AU - Nagarkatti, Rana AU - Gupta, Charu AU - Marino, Ana Paula AU - Debrabant, Alain AD - Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, United States of America Y1 - 2015/01/08/ PY - 2015 DA - 2015 Jan 08 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 9 IS - 1 SN - 1935-2727, 1935-2727 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Aptamers KW - Parasites KW - Animal models KW - Disease control KW - Biomarkers KW - Hosts KW - Drug screening KW - Infection KW - Morbidity KW - Public health KW - Disease transmission KW - Drug discovery KW - Disease detection KW - Drugs KW - Vectors KW - Enzymes KW - biomarkers KW - nifurtimox KW - Blood KW - parasitemia KW - Benznidazole KW - Vaccines KW - Side effects KW - Chagas' disease KW - K 03410:Animal Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660391667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Aptamer-Based+Detection+of+Disease+Biomarkers+in+Mouse+Models+for+Chagas+Drug+Discovery&rft.au=de+Araujo%2C+Fernanda+Fortes%3BNagarkatti%2C+Rana%3BGupta%2C+Charu%3BMarino%2C+Ana+Paula%3BDebrabant%2C+Alain&rft.aulast=de+Araujo&rft.aufirst=Fernanda&rft.date=2015-01-08&rft.volume=9&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0003451 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Parasites; Disease control; Disease detection; Vaccines; Hosts; Biomarkers; Drugs; Disease transmission; Public health; Aptamers; Animal models; Enzymes; Vectors; Infection; Drug screening; biomarkers; Morbidity; Blood; nifurtimox; Drug discovery; parasitemia; Benznidazole; Side effects; Chagas' disease DO - http://dx.doi.org/10.1371/journal.pntd.0003451 ER - TY - JOUR T1 - Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis. AN - 1640330413; 25445804 AB - The tyrosine kinase inhibitor regorafenib was approved by regulatory agencies for cancer treatment, albeit with strong warnings of severe hepatotoxicity included in the product label. The basis of this toxicity is unknown; one possible mechanism, that of mitochondrial damage, was tested. In isolated rat liver mitochondria, regorafenib directly uncoupled oxidative phosphorylation (OXPHOS) and promoted calcium overload-induced swelling, which were respectively prevented by the recoupler 6-ketocholestanol (KC) and the mitochondrial permeability transition (MPT) pore blocker cyclosporine A (CsA). In primary hepatocytes, regorafenib uncoupled OXPHOS, disrupted mitochondrial inner membrane potential (MMP), and decreased cellular ATP at 1h, and triggered MPT at 3h, which was followed by necrosis but not apoptosis at 7h and 24h, all of which were abrogated by KC. The combination of the glycolysis enhancer fructose plus the mitochondrial ATPase synthase inhibitor oligomycin A abolished regorafenib induced necrosis at 7h. This effect was not seen at 24h nor with the fructose or oligomycin A separately. CsA in combination with trifluoperazine, both MPT blockers, showed similar effects. Two compensatory mechanisms, activation of AMP-activated protein kinase (AMPK) to ameliorate ATP shortage and induction of autophagy to remove dysfunctional mitochondria, were found to be mobilized. Hepatocyte necrosis was enhanced either by the AMPK inhibitor Compound C or the autophagy inhibitor chloroquine, while autophagy inducer rapamycin was strongly cytoprotective. Remarkably, all toxic effects were observed at clinically-relevant concentrations of 2.5-15μM. These data suggest that uncoupling of OXPHOS and the resulting ATP shortage and MPT induction are the key mechanisms for regorafenib induced hepatocyte injury, and AMPK activation and autophagy induction serve as pro-survival pathways against such toxicity. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Weng, Zuquan AU - Luo, Yong AU - Yang, Xi AU - Greenhaw, James J AU - Li, Haibo AU - Xie, Liming AU - Mattes, William B AU - Shi, Qiang AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; PharmPoint Consulting, 17014 Hersperger Lane, Poolesville, MD 20837, USA. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: qiang.shi@fda.hhs.gov. Y1 - 2015/01/02/ PY - 2015 DA - 2015 Jan 02 SP - 10 EP - 21 VL - 327 KW - Phenylurea Compounds KW - 0 KW - Pyridines KW - regorafenib KW - 24T2A1DOYB KW - AMP-Activated Protein Kinases KW - EC 2.7.11.1 KW - Index Medicus KW - Rat KW - Hepatocyte KW - Necrosis KW - Regorafenib KW - Mitochondrion KW - Hepatotoxicity KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Enzyme Activation KW - Male KW - Autophagy -- drug effects KW - Hepatocytes -- drug effects KW - AMP-Activated Protein Kinases -- metabolism KW - Mitochondria, Liver -- physiology KW - Mitochondria, Liver -- drug effects KW - Hepatocytes -- cytology KW - Pyridines -- pharmacology KW - Phenylurea Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1640330413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Regorafenib+impairs+mitochondrial+functions%2C+activates+AMP-activated+protein+kinase%2C+induces+autophagy%2C+and+causes+rat+hepatocyte+necrosis.&rft.au=Weng%2C+Zuquan%3BLuo%2C+Yong%3BYang%2C+Xi%3BGreenhaw%2C+James+J%3BLi%2C+Haibo%3BXie%2C+Liming%3BMattes%2C+William+B%3BShi%2C+Qiang&rft.aulast=Weng&rft.aufirst=Zuquan&rft.date=2015-01-02&rft.volume=327&rft.issue=&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2014.11.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-24 N1 - Date created - 2014-12-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2014.11.002 ER - TY - JOUR T1 - Determination of Phosphodiesterase-5 Inhibitors and Analogs Using High-Performance Liquid Chromatography with Ultraviolet Detection AN - 1823944679; PQ0001720257 AB - A considerable number of erectile dysfunction products, and dietary supplements suspected of containing phosphodiesterase-5 (PDE-5) inhibitors, have been analyzed by the US Food and Drug Administration. Often these samples are found to contain the approved active pharmaceutical ingredients (APIs) such as sildenafil, tadalafil or vardenafil. However, analogs of these APIs have also been identified in many samples and products containing multiple PDE-5 inhibitors have also been found. A single high-performance liquid chromatography with ultraviolet detection method has been developed for the determination of sildenafil, tadalafil, vardenafil and a number of commonly encountered analogs in pharmaceutical dosage forms and dietary supplement products, including tablets, capsules, bulk powders, troches and liquids. This method was designed as an alternative to methods developed for the determination of a single PDE-5 inhibitor. Using this protocol, 14 PDE-5 inhibitor compounds can be separated and determined in a single analysis. JF - Journal of Chromatographic Science AU - Nickum, Elisa A AU - Flurer, Cheryl L AD - U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA, elisa.nickum@fda.hhs.gov Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 38 EP - 46 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 53 IS - 1 SN - 0021-9665, 0021-9665 KW - Toxicology Abstracts KW - High-performance liquid chromatography KW - Powder KW - U.V. radiation KW - Dietary supplements KW - Tablets KW - Pharmaceuticals KW - Sildenafil KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823944679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatographic+Science&rft.atitle=Determination+of+Phosphodiesterase-5+Inhibitors+and+Analogs+Using+High-Performance+Liquid+Chromatography+with+Ultraviolet+Detection&rft.au=Nickum%2C+Elisa+A%3BFlurer%2C+Cheryl+L&rft.aulast=Nickum&rft.aufirst=Elisa&rft.date=2015-01-01&rft.volume=53&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatographic+Science&rft.issn=00219665&rft_id=info:doi/10.1093%2Fchromsci%2Fbmu010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Powder; U.V. radiation; Dietary supplements; Tablets; Pharmaceuticals; Sildenafil DO - http://dx.doi.org/10.1093/chromsci/bmu010 ER - TY - JOUR T1 - Pressure drop of filtering facepiece respirators: How low should we go? AN - 1811885201; PQ0003508347 AB - Introduction: This study was undertaken to determine the mean peak filter resistance to airflow (Rfilter) encountered by subjects while wearing prototype filtering facepiece respirators (PRs) with low Rfilter during nasal and oral breathing at sedentary and low-moderate work rates. Material and methods: In-line pressure transducer measurements of mean Rfilteracross PRs with nominal Rfilter of 29.4 Pa, 58.8 Pa and 88.2 Pa (measured at 85 l/min constant airflow) were obtained during nasal and oral breathing at sedentary and low-moderate work rates for 10 subjects. Results: The mean Rfilter for the 29.4 PR was significantly lower than the other 2 PRs (p 0.05). The mean Rfilter was greater for oral versus nasal breathing and for exercise compared to sedentary activity (p < 0.001). Conclusions: Mean oral and nasal Rfilter for all 3 PRs was at, or below, the minimal threshold level for detection of inspiratory resistance (the 58.8-74.5 Pa/lxs-1), which may account for the previously-reported lack of significant subjective or physiological differences when wearing PRs with these low Rfilter. Lowering filtering facepiece respirator Rfilter below 88.2 Pa (measured at 85 l/min constant airflow) may not result in additional subjective or physiological benefit to the wearer. JF - International Journal of Occupational Medicine and Environmental Health AU - Kim, Jung-Hyun AU - Roberge, Raymond J AU - Powell, Jeffrey B AU - Shaffer, Ronald E AU - Ylitalo, Caroline M AU - Sebastian, John M AD - Centers for Disease Control and Prevention, Pittsburgh, Pennsylvania, United States of America (National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Technology Research Branch) Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 71 EP - 80 PB - Nofer Institute of Occupational Medicine, Ul Sw Teresy 0 Lodz 90950 Poland VL - 28 IS - 1 SN - 1232-1087, 1232-1087 KW - Health & Safety Science Abstracts KW - respirator KW - filter KW - oral breathing KW - nasal breathing KW - Filters KW - Transducers KW - Prototypes KW - Physiology KW - Respirators KW - Protective equipment KW - Air flow KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811885201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Occupational+Medicine+and+Environmental+Health&rft.atitle=Pressure+drop+of+filtering+facepiece+respirators%3A+How+low+should+we+go%3F&rft.au=Kim%2C+Jung-Hyun%3BRoberge%2C+Raymond+J%3BPowell%2C+Jeffrey+B%3BShaffer%2C+Ronald+E%3BYlitalo%2C+Caroline+M%3BSebastian%2C+John+M&rft.aulast=Kim&rft.aufirst=Jung-Hyun&rft.date=2015-01-01&rft.volume=28&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Occupational+Medicine+and+Environmental+Health&rft.issn=12321087&rft_id=info:doi/10.13075%2Fijomeh.1896.00153 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Filters; Transducers; Prototypes; Physiology; Respirators; Protective equipment; Air flow DO - http://dx.doi.org/10.13075/ijomeh.1896.00153 ER - TY - GEN T1 - A Resource Guide for Head Start Programs: Moving beyond a Culture of Compliance to a Culture of Continuous Improvement. OPRE Report 2015-02 AN - 1773223074; ED558548 AB - Head Start has long focused on assessing and improving program quality to ensure that the children served receive the best possible preparation for school and life. Most research has been focused inside the classroom--the classroom environment, teacher qualifications, and teacher interactions. Of course, the classroom is important because that is where children spend most of their time, but what is done in the classroom isn't entirely--or primarily--the teacher's decision. The management and leadership of the program typically make the decisions about which curriculum and assessments to use, the equipment and materials to provide, and how to interact with the children. Thus, it is important to study, understand, and provide guidance for those managers and leaders in their decisions. Accordingly, the Office of Planning, Research and Evaluation (OPRE) contracted with the Urban Institute in 2012 to conduct the Head Start Leadership, Excellence, and Data Systems (LEADS) project. The LEADS project's goal is to understand the factors in organizational and management systems that promote effective early childhood education practices and outcomes. The LEADS project has three primary products: (1) a literature review and conceptual framework drawing from the work of other disciplines that have studied data use for quality improvement; (2) documentation of promising practices in Head Start programs around data use for continuous quality improvement; and (3) this resource guide to translate the research into information community-based Head Start programs can use. The purpose of this resource guide is to help leadership, management, supervisory, and data-focused staff in Head Start and Early Head Start programs: (1) understand how data, including the data they already collect, can help them achieve their program goals; (2) learn techniques for fostering a culture of learning in their organization; and (3) increase their ability to identify and address gaps and continuously improve their programs. This document provides guidance on enhancing data use for quality improvement by drawing upon LEADS project research on data use in other fields, promising practices observed in Head Start programs, and existing Head Start technical assistance and training materials. Fostering data use and a learning culture is hard work; it helps to have multiple resources from which to draw. The following are appended: (1) Aligning this Resource Guide with Existing Head Start National Center Program Management and Fiscal Operations (PMFO) Technical Assistance Materials; (2) Continuous Quality Improvement: Conceptual Framework; (3) Head Start Frameworks for Continuous Program Improvement; and (4) Resource List. AU - Derrick-Mills, Teresa AU - Winkler, Mary K. AU - Healy, Olivia AU - Greenberg, Erica Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 85 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Early Childhood Education KW - Stakeholders KW - Program Effectiveness KW - Educational Objectives KW - Low Income KW - Guidelines KW - Educational Improvement KW - Holistic Approach KW - Program Improvement KW - Educational Development KW - Best Practices KW - Information Utilization KW - Federal Programs KW - Staff Utilization KW - Disadvantaged Youth KW - Data Collection KW - Compliance (Legal) KW - Data Analysis KW - Preschool Children KW - School Readiness KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773223074?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - Portfolio of Research in Welfare and Family Self-Sufficiency: FY 2014. OPRE Report 2015-15 AN - 1773221725; ED558550 AB - The Division of Economic Independence within the Office of Planning, Research and Evaluation (OPRE) has primary responsibility for welfare and family self-sufficiency research. OPRE's research in the area of welfare and family self-sufficiency is designed to expand knowledge about effective programs to promote employment, self-sufficiency, and economic well-being among low-income families. Research focuses on four major areas: (1) Temporary Assistance for Needy Families (TANF) and the Safety Net; (2) Employment and the Labor Market; (3) Education and Training; and (4) Other and Cross-Cutting Research. Within these areas, OPRE funds experimental impact evaluations, implementation evaluations, and descriptive research projects aimed at informing the design and implementation of programs. OPRE also invests in activities to disseminate rigorous research on welfare and family self-sufficiency topics. This portfolio describes major welfare and family self-sufficiency research projects sponsored by OPRE in Fiscal Year 2014. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 27 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Temporary Assistance for Needy Families KW - ERIC, Resources in Education (RIE) KW - Postsecondary Education KW - Adult Education KW - Low Income Groups KW - Well Being KW - Federal Programs KW - Research Projects KW - Welfare Services KW - Labor Market KW - Employment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773221725?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - Services for Families of Infants and Toddlers Experiencing Trauma. A Research-to-Practice Brief. OPRE Report 2015-14 AN - 1773221645; ED558495 AB - Infancy is a time of extreme opportunity, but it is also a time of extreme vulnerability, particularly for those reared in high-risk environments. Although infant exposure to any risk is important to understand, this brief focuses on the experience and impact of "trauma," defined as witnessing or experiencing an event that poses a real or perceived threat. Beginning life in the context of trauma places infants and toddlers on a compromised developmental path. Because of this, the impact of trauma on infants and toddlers can be particularly harmful. On the other hand, the developmental plasticity (i.e., the potential for developmental change in response to the environment) during this early period of life may allow infants and toddlers to rebound from these traumatic experiences, particularly if they experience "stable, nurturing caregiving." The author briefly summarizes what is known about the impact of trauma on infants and toddlers, and the intervention strategies that could potentially protect them from the adverse consequences of traumatic experiences. She focuses on interventions that support parents in providing the stable and nurturing caregiving that is responsive to the child's general developmental needs and that promotes children's sense of safety and security. Such interventions may reduce or provide a buffer against infants' traumatic experiences. Finally, the author considers how child care, Early Head Start, home visitation, and child welfare can become trauma-informed infant/toddler service delivery systems. AU - Harden, Branda Jones Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 16 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Toddlers KW - Parent Role KW - Delivery Systems KW - Intervention KW - Child Care KW - Child Welfare KW - Psychological Patterns KW - Parent Child Relationship KW - Child Rearing KW - Child Development KW - At Risk Persons KW - Family Environment KW - Home Visits KW - Mental Health KW - Child Safety KW - Screening Tests KW - Trauma KW - Family Counseling KW - Counseling Techniques KW - Psychotherapy KW - Family Programs KW - Early Intervention KW - Attachment Behavior KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773221645?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - GEN T1 - The Mother and Infant Home Visiting Program Evaluation: Early Findings on the Maternal, Infant, and Early Childhood Home Visiting Program. A Report to Congress. OPRE Report 2015-11 AN - 1773213413; ED558512 AB - "The Mother and Infant Home Visiting Program Evaluation: Early Findings on the Maternal, Infant, and Early Childhood Home Visiting Program--A Report to Congress" presents the first findings from the Mother and Infant Home Visiting Program Evaluation (MIHOPE), the legislatively mandated national evaluation of the Maternal, Infant, and Early Childhood Home Visiting program (MIECHV or the Home Visiting Program). The report includes an analysis of the states' needs assessments, as well as baseline characteristics of families, staff, local programs, and models participating in the study. The information in this report provides a foundation for understanding the implementation and impacts of MIECHV-funded home visiting programs. Later reports will explore the local and national implementation of those programs, and their effects on families with young children. The study is being overseen by OPRE and conducted by MDRC in partnership with James Bell Associates, Johns Hopkins University, Mathematica Policy Research, the University of Georgia, and Columbia University. The study's design and plans for the content of the Report to Congress reflect advice from the Secretary's Advisory Committee on the Maternal, Infant and Early Childhood Home Visiting Program Evaluation. The following are appended: (1) Home Visiting Programs in Existence Before MIECHV, as Reported in the 2010 State Needs Assessments; (2) Programs in Use in Only One State Prior to MIECHV, as Reported in the 2010 State Needs Assessments; (3) Indicators of Community Risk in Communities Chosen for MIECHV Funding, Based on the 2010 State Needs Assessments; (4) Fiscal Year 2010 and 2011 State Plans for MIECHV Funding; and (5) Chapter 5 Supplement: Additional Information on the Home Visiting Implementation Policies of National Models and Local Programs. AU - Michalopoulos, Charles AU - Lee, Helen AU - Duggan, Anne AU - Lundquist, Erika AU - Tso, Ada AU - Crowne, Sarah Shea AU - Burrell, Lori AU - Somers, Jennifer AU - Filene, Jill H. AU - Knox, Virginia Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 488 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - California KW - Georgia KW - Illinois KW - Iowa KW - Kansas KW - Michigan KW - Nevada KW - New Jersey KW - Pennsylvania KW - South Carolina KW - Washington KW - Wisconsin KW - ERIC, Resources in Education (RIE) KW - Program Descriptions KW - Family Characteristics KW - Federal Legislation KW - Federal Programs KW - Program Implementation KW - Mothers KW - Home Visits KW - Early Intervention KW - Program Evaluation KW - Needs Assessment KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773213413?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Effects of grazing, nutrients, and depth on the ciguatera-causing dinoflagellate Gambierdiscus in the US Virgin Islands AN - 1762365201; PQ0002505674 AB - Ciguatera fish poisoning in humans is a serious and widespread syndrome associated with the consumption of reef fishes that have accumulated lipid-soluble toxins known as ciguatoxins. These toxins are piscine metabolites of ciguatoxin precursors produced by benthic dinoflagellates in the genus Gambierdiscus. This investigation employed a novel experimental approach to identify and characterize the environmental factors and their interactions that influence the dynamic balance between cellular growth and loss of Gambierdiscus populations in situ. Field studies were conducted in St. Thomas (US Virgin Islands) at 3 sites and 2 depths (10 and 20 m). At each site and depth, Gambierdiscus was subjected to treatments designed to reduce grazing pressure (disturbance and removal) and elevate nutrient availability to elicit a population abundance response attributable to one of these treatments. We hypothesized that Gambierdiscus abundance would respond positively to increased nutrient availability, increasing depth (reduced water motion), and decreased grazing pressures. We found communities of Gambierdiscus were significantly higher by, on average, 138% when the effects of grazing were limited (p = 0.0002). Among sites, the effects of depth and nutrients on Gambierdiscus populations were not significant. The significant effect of grazing and disturbance observed in this study suggests that changes in reef herbivore and detritivore feeding selectivity and grazing rates may have large impacts on the areal density of Gambierdiscus in natural systems. Whether or not reduced grazing rates or disturbances translate into higher cell (toxin) ingestion rates for consumers and ultimately cause changes in toxicity for humans is unknown and in need of further investigation. JF - Marine Ecology Progress Series AU - Loeffler, Christopher R AU - Richlen, Mindy L AU - Brandt, Marilyn E AU - Smith, Tyler B AD - Center for Marine and Environmental Studies, University of the Virgin Islands, 2 John Brewers Bay, St Thomas, US Virgin Islands 00802, USA, christopher.loeffler@fda.hhs.gov Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 91 EP - 104 PB - Inter-Research, Nordbuente 23 Oldendorf/Luhe 21385 Germany VL - 531 SN - 0171-8630, 0171-8630 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Ciguatera fish poisoning KW - Gambierdiscus KW - Caging KW - Grazing KW - St. Thomas KW - Coral reefs KW - Fish survey KW - Management KW - Reefs KW - ASW, Caribbean Sea, Lesser Antilles, US Virgin Is. KW - Toxicants KW - Abundance KW - Phytoplankton KW - Metabolites KW - Nutrients KW - Environmental factors KW - Growth KW - Islands KW - Feeding behaviour KW - Dinoflagellates KW - Consumers KW - detritivores KW - Pressure KW - Marine KW - Feeding KW - Nutrient availability KW - Poisoning KW - Environmental impact KW - Toxicity KW - Toxins KW - Ecosystem disturbance KW - Ciguatera KW - Herbivores KW - Food preferences KW - Ciguatoxin KW - O 5080:Legal/Governmental KW - D 04040:Ecosystem and Ecology Studies KW - K 03450:Ecology KW - Q1 08567:Fishery oceanography and limnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762365201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Ecology+Progress+Series&rft.atitle=Effects+of+grazing%2C+nutrients%2C+and+depth+on+the+ciguatera-causing+dinoflagellate+Gambierdiscus+in+the+US+Virgin+Islands&rft.au=Loeffler%2C+Christopher+R%3BRichlen%2C+Mindy+L%3BBrandt%2C+Marilyn+E%3BSmith%2C+Tyler+B&rft.aulast=Loeffler&rft.aufirst=Christopher&rft.date=2015-01-01&rft.volume=531&rft.issue=&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Marine+Ecology+Progress+Series&rft.issn=01718630&rft_id=info:doi/10.3354%2Fmeps11310 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Growth; Toxicants; Feeding behaviour; Grazing; Environmental impact; Phytoplankton; Ciguatoxin; Food preferences; Ecosystem disturbance; Feeding; Reefs; Nutrient availability; Abundance; Poisoning; Nutrients; Metabolites; Toxicity; Environmental factors; Toxins; Ciguatera; Herbivores; Islands; Dinoflagellates; Consumers; Pressure; detritivores; Gambierdiscus; ASW, Caribbean Sea, Lesser Antilles, US Virgin Is.; Marine DO - http://dx.doi.org/10.3354/meps11310 ER - TY - JOUR T1 - Identifying Similar Cases in Document Networks Using Cross-Reference Structures AN - 1753470812; PQ0002431018 AB - Our objective was to explore the creation of document networks based on different thresholds of shared information and different clustering algorithms on those networks to identify document clusters describing similar clinical cases. We created networks from vaccine adverse event report sets using seven approaches for linking reports. We then applied three clustering algorithms [visualization of similarities (VOS), Louvain, k-means] to these networks and evaluated their ability to identify known clusters. The report sets included one simulated set and three sets from the Vaccine Adverse Event Reporting System; each was split into training and testing subsets. Training subsets were used to estimate parameter values for the clustering algorithms and testing subsets to evaluate clusters. We created the networks by linking reports based on shared information in the form either of individual Medical Dictionary for Regulatory Activities Preferred Terms (PTs) or of dyads, triplets, quadruplets, quintuplets, and sextuplets of PTs; we created another network by weighting the single PT network connections by Lin's information theoretic approach to similarity. We then repeated this entire process using networks based on text mining output rather than structured data. We evaluated report clustering using recall, precision, and f-measure. The VOS algorithm outperformed Louvain and k-means in general. The best weighting scheme appeared to be related to the complexity of the known cluster. For example, singleton weighting performed best for an intussusception cluster driven by a single PT. We observed marginal differences between the code- and textual-based clustering. In conclusion, our approach supported identification of similar nodes in a document network. JF - IEEE Journal of Biomedical and Health Informatics AU - Botsis, Taxiarchis AU - Scott, John AU - Woo, Emily Jane AU - Ball, Robert AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, MD, USA PY - 2015 SP - 1906 EP - 1917 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 United States VL - 19 IS - 6 SN - 2168-2194, 2168-2194 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Informatics KW - intussusception KW - Algorithms KW - Vaccines KW - Nodes KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753470812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Journal+of+Biomedical+and+Health+Informatics&rft.atitle=Identifying+Similar+Cases+in+Document+Networks+Using+Cross-Reference+Structures&rft.au=Botsis%2C+Taxiarchis%3BScott%2C+John%3BWoo%2C+Emily+Jane%3BBall%2C+Robert&rft.aulast=Botsis&rft.aufirst=Taxiarchis&rft.date=2015-01-01&rft.volume=19&rft.issue=6&rft.spage=1906&rft.isbn=&rft.btitle=&rft.title=IEEE+Journal+of+Biomedical+and+Health+Informatics&rft.issn=21682194&rft_id=info:doi/10.1109%2FJBHI.2014.2345873 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Data processing; Informatics; intussusception; Algorithms; Vaccines; Nodes DO - http://dx.doi.org/10.1109/JBHI.2014.2345873 ER - TY - JOUR T1 - Modern analytics for synthetically derived complex drug substances: NMR, AFFF-MALS, and MS tests for glatiramer acetate AN - 1751215798; PQ0002364437 AB - Glatiramer acetate (GA) is a mixture of synthetic copolymers consisting of four amino acids (glutamic acid, lysine, alanine, and tyrosine) with a labeled molecular weight range of 5000 to 9000 Da. GA is marketed as Copaxone(TM) by Teva for the treatment of multiple sclerosis. Here, the agency has evaluated the structure and composition of GA and a commercially available comparator, Copolymer-1. Modern analytical technologies which can characterize these complex mixtures are desirable for analysis of their comparability and structural "sameness." In the studies herein, a molecular fingerprinting approach is taken using mass-accurate mass spectrometry (MS) analysis, nuclear magnetic resonance (NMR) (1D- super(1)H-NMR, 1D- super(13)C-NMR, and 2D NMR), and asymmetric field flow fractionation (AFFF) coupled with multi-angle light scattering (MALS) for an in-depth characterization of three lots of the marketplace drug and a formulated sample of the comparator. Statistical analyses were applied to the MS and AFFF-MALS data to assess these methods' ability to detect analytical differences in the mixtures. The combination of multiple orthogonal measurements by liquid chromatography coupled with MS (LC-MS), AFFF-MALS, and NMR on the same sample set was found to be fit for the intended purpose of distinguishing analytical differences between these complex mixtures of peptide chains. JF - Analytical and Bioanalytical Chemistry AU - Rogstad, Sarah AU - Pang, Eric AU - Sommers, Cynthia AU - Hu, Meng AU - Jiang, Xiaohui AU - Keire, David A AU - Boyne, Michael T AD - Division of Pharmaceutical Analysis, Office of Testing and Research, Center for Drug Evaluation and Research, US Food and Drug Administration, 645 S. Newstead Ave., St. Louis, MO, 63110, USA, david.keire@fda.hhs.gov PY - 2015 SP - 8647 EP - 8659 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 407 IS - 29 SN - 1618-2642, 1618-2642 KW - Water Resources Abstracts; Aqualine Abstracts KW - Testing Procedures KW - Mass Spectrometry KW - Amino Acids KW - Weight KW - Acids KW - Statistical Analysis KW - Liquid Chromatography KW - Drugs KW - AQ 00001:Water Resources and Supplies KW - SW 5010:Network design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751215798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Modern+analytics+for+synthetically+derived+complex+drug+substances%3A+NMR%2C+AFFF-MALS%2C+and+MS+tests+for+glatiramer+acetate&rft.au=Rogstad%2C+Sarah%3BPang%2C+Eric%3BSommers%2C+Cynthia%3BHu%2C+Meng%3BJiang%2C+Xiaohui%3BKeire%2C+David+A%3BBoyne%2C+Michael+T&rft.aulast=Rogstad&rft.aufirst=Sarah&rft.date=2015-01-01&rft.volume=407&rft.issue=29&rft.spage=8647&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-015-9057-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 25 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Testing Procedures; Mass Spectrometry; Amino Acids; Weight; Acids; Statistical Analysis; Liquid Chromatography; Drugs DO - http://dx.doi.org/10.1007/s00216-015-9057-8 ER - TY - JOUR T1 - Infection of Murine Macrophages by Salmonella enterica Serovar Heidelberg Blocks Murine Norovirus Infectivity and Virus-induced Apoptosis. AN - 1750002704; 26658916 AB - Gastroenteritis caused by bacterial and viral pathogens constitutes a major public health threat in the United States accounting for 35% of hospitalizations. In particular, Salmonella enterica and noroviruses cause the majority of gastroenteritis infections, with emergence of sporadic outbreaks and incidence of increased infections. Although mechanisms underlying infections by these pathogens have been individually studied, little is known about the mechanisms regulating co-infection by these pathogens. In this study, we utilized RAW 264.7 murine macrophage cells to investigate the mechanisms governing co-infection with S. enterica serovar Heidelberg and murine norovirus (MNV). We demonstrate that infection of RAW 264.7 cells with S. enterica reduces the replication of MNV, in part by blocking virus entry early in the virus life cycle, and inducing antiviral cytokines later in the infection cycle. In particular, bacterial infection prior to, or during MNV infection affected virus entry, whereas MNV entry remained unaltered when the virus infection preceded bacterial invasion. This block in virus entry resulted in reduced virus replication, with the highest impact on replication observed during conditions of co-infection. In contrast, bacterial replication showed a threefold increase in MNV-infected cells, despite the presence of antibiotic in the medium. Most importantly, we present evidence that the infection of MNV-infected macrophages by S. enterica blocked MNV-induced apoptosis, despite allowing efficient virus replication. This apoptosis blockade was evidenced by reduction in DNA fragmentation and absence of poly-ADP ribose polymerase (PARP), caspase 3 and caspase 9 cleavage events. Our study suggests a novel mechanism of pathogenesis whereby initial co-infection with these pathogens could result in prolonged infection by either of these pathogens or both together. JF - PloS one AU - Agnihothram, Sudhakar S AU - Basco, Maria D S AU - Mullis, Lisa AU - Foley, Steven L AU - Hart, Mark E AU - Sung, Kidon AU - Azevedo, Marli P AD - Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 12 KW - Cytokines KW - 0 KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Virus Replication KW - Macrophages -- cytology KW - Animals KW - Macrophages -- microbiology KW - Macrophages -- virology KW - Cytokines -- metabolism KW - Mice KW - Virus Internalization KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Microscopy, Fluorescence KW - Cytokines -- analysis KW - Enzyme-Linked Immunosorbent Assay KW - Up-Regulation KW - DNA Fragmentation KW - Cell Line KW - Caspase 3 -- metabolism KW - Coinfection KW - Norovirus -- physiology KW - Norovirus -- pathogenicity KW - Salmonella enterica -- pathogenicity KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1750002704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Infection+of+Murine+Macrophages+by+Salmonella+enterica+Serovar+Heidelberg+Blocks+Murine+Norovirus+Infectivity+and+Virus-induced+Apoptosis.&rft.au=Agnihothram%2C+Sudhakar+S%3BBasco%2C+Maria+D+S%3BMullis%2C+Lisa%3BFoley%2C+Steven+L%3BHart%2C+Mark+E%3BSung%2C+Kidon%3BAzevedo%2C+Marli+P&rft.aulast=Agnihothram&rft.aufirst=Sudhakar&rft.date=2015-01-01&rft.volume=10&rft.issue=12&rft.spage=e0144911&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0144911 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-06 N1 - Date created - 2015-12-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Med Microbiol Immunol. 2006 Mar;195(1):11-9 [16086183] Curr Top Microbiol Immunol. 2014;385:327-56 [25027822] Pediatr Infect Dis J. 2006 Feb;25(2):160-4 [16462295] Infect Immun. 2006 May;74(5):2562-7 [16622191] J Virol. 2006 Jun;80(11):5104-12 [16698991] Vaccine. 2006 Jun 12;24(24):5220-34 [16650512] Biofactors. 1998;8(3-4):283-5 [9914830] J Virol. 1999 Apr;73(4):2650-7 [10074110] Exp Cell Res. 2001 Oct 1;269(2):193-201 [11570811] Microbes Infect. 2001 Nov-Dec;3(14-15):1321-6 [11755421] Antioxid Redox Signal. 2002 Oct;4(5):769-81 [12470504] Arch Pharm Res. 2002 Dec;25(6):895-902 [12510845] J Clin Invest. 1991 Aug;88(2):540-5 [1907615] Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6285-9 [1378624] J Gen Virol. 1993 Aug;74 ( Pt 8):1653-6 [8345356] J Gen Virol. 1994 Aug;75 ( Pt 8):1883-8 [8046390] Biochim Biophys Acta. 1998 Aug 10;1366(1-2):177-96 [9714796] PLoS Biol. 2004 Dec;2(12):e432 [15562321] J Biol Chem. 2005 Mar 11;280(10):9058-64 [15642738] J Infect. 2006 Dec;53(6):408-14 [16490255] Toxicol Pathol. 2007 Jun;35(4):495-516 [17562483] Emerg Infect Dis. 2008 Aug;14(8):1224-31 [18680645] PLoS Pathog. 2008 Dec;4(12):e1000236 [19079577] J Virol. 2009 Apr;83(8):3647-56 [19211757] J Appl Microbiol. 2009 Jul;107(1):65-71 [19298511] J Virol. 2011 Jan;85(1):231-42 [20980508] J Infect Dis. 2011 Mar 15;203(6):880-8 [21278211] Appl Environ Microbiol. 2011 Jul;77(13):4273-9 [21571882] Clin Infect Dis. 2011 Sep;53(6):568-71 [21832262] PLoS One. 2011;6(9):e24286 [21931672] Clin Microbiol Infect. 2011 Dec;17(12):1895-9 [21848976] J Vis Exp. 2012;(66):e4297 [22951568] Influenza Other Respir Viruses. 2013 Mar;7(2):168-76 [22487223] Am J Infect Control. 2013 Jul;41(7):654-7 [23266383] Emerg Infect Dis. 2013 Aug;19(8):1214-21 [23876432] Science. 2014 Nov 7;346(6210):755-9 [25378626] PLoS Med. 2015 Jan;12(1):e1001776 [25562317] J Clin Microbiol. 2015 Feb;53(2):373-81 [24989606] Curr Opin Microbiol. 2015 Feb;23:23-31 [25461569] ScientificWorldJournal. 2015;2015:520179 [25664339] Foodborne Pathog Dis. 2015 Jun;12(6):492-9 [26067228] Epidemiol Infect. 2015 Sep;143(12):2473-85 [25600652] Expert Rev Vaccines. 2015;14(9):1241-53 [26224658] Curr Opin Microbiol. 2006 Feb;9(1):102-8 [16406838] PLoS One. 2013;8(9):e72788 [24023773] PLoS One. 2013;8(10):e77866 [24098597] Microbiol Mol Biol Rev. 2013 Dec;77(4):582-607 [24296573] Nat Rev Microbiol. 2014 Apr;12(4):252-62 [24590244] Curr Protoc Microbiol. 2014;33:15K.2.1-61 [24789596] Clin Infect Dis. 2014 Jun;58(12):1746-52 [24585561] Cell Host Microbe. 2014 Jun 11;15(6):668-80 [24922570] Lancet Infect Dis. 2014 Aug;14(8):725-30 [24981041] J Virol. 2014 Aug;88(16):9277-86 [24899198] Cell Host Microbe. 2014 Aug 13;16(2):249-56 [25121752] J Gen Virol. 2014 Sep;95(Pt 9):1958-68 [24899153] J Clin Microbiol. 2016 Jan;54(1):142-7 [26560532] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0144911 ER - TY - JOUR T1 - Modern analytics for naturally derived complex drug substances: NMR and MS tests for protamine sulfate from chum salmon AN - 1746896690; PQ0001516044 AB - This work describes orthogonal NMR and MS tests for the structure and composition of the drug protamine sulfate derived from chum salmon. The spectral response pattern obtained by 1D-[sup 1]H-NMR and MS methods from salmon protamine, a mixture of four predominant peptide chaths, is dependent on the amino acid sequence and abundance of each peptide. Thus, an assay was developed based on the ratios of alanine, glycine and arginine amino acid residue NMR peaks in this mixture that are unique to the salmon source. The specificity of the combined NMR and MS assay was tested by comparison to data obtained from herring protamine which contains a different mixture of peptides with related amino acid sequences. Both assays were able to clearly distinguish protamine derived from these different natural sources. JF - Analytical and Bioanalytical Chemistry AU - Gucinski, Ashley C AU - Boyne, Michael T, II AU - Keire, David A AD - Division of Pharmaceutical Research, Office of Testing and Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 645 S. Newstead Ave., St. Louis, MO 63110, USA, david.keire@fda.hhs.gov PY - 2015 SP - 749 EP - 759 PB - Springer Science+Business Media VL - 407 IS - 3 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - NMR KW - LC-MS KW - Peptide drug quality KW - Salmon KW - Testing Procedures KW - Sulfates KW - Amino Acids KW - Fish (herring family) KW - Assay KW - Peptides KW - Drugs KW - AQ 00001:Water Resources and Supplies KW - SW 5010:Network design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746896690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Modern+analytics+for+naturally+derived+complex+drug+substances%3A+NMR+and+MS+tests+for+protamine+sulfate+from+chum+salmon&rft.au=Gucinski%2C+Ashley+C%3BBoyne%2C+Michael+T%2C+II%3BKeire%2C+David+A&rft.aulast=Gucinski&rft.aufirst=Ashley&rft.date=2015-01-01&rft.volume=407&rft.issue=3&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-014-8172-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 26 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Sulfates; Testing Procedures; Salmon; Amino Acids; Fish (herring family); Assay; Peptides; Drugs DO - http://dx.doi.org/10.1007/s00216-014-8172-2 ER - TY - JOUR T1 - Filament Dynamics during Simulated Ventricular Fibrillation in a High-Resolution Rabbit Heart AN - 1746894458; PQ0002314741 AB - The mechanisms underlying ventricular fibrillation (VF) are not well understood. The electrical activity on the heart surface during VF has been recorded extensively in the experimental setting and in some cases clinically; however, corresponding transmural activation patterns are prohibitively difficult to measure. In this paper, we use a high-resolution biventricular heart model to study three-dimensional electrical activity during fibrillation, focusing on the driving sources of VF: "filaments," the organising centres of unstable reentrant scroll waves. We show, for the first time, specific 3D filament dynamics during simulated VF in a whole heart geometry that includes fine-scale anatomical structures. Our results suggest that transmural activity is much more complex than what would be expected from surface observations alone. We present examples of complex intramural activity, including filament breakup and reattachment, anchoring to the thin right ventricular apex; rapid transitions among various filament shapes; and filament lengths much greater than wall thickness. We also present evidence for anatomy playing a major role in VF development and coronary vessels and trabeculae influencing filament dynamics. Overall, our results indicate that intramural activity during simulated VF is extraordinarily complex and suggest that further investigation of 3D filaments is necessary to fully comprehend recorded surface patterns. JF - BioMed Research International AU - Pathmanathan, Pras AU - Gray, Richard A AD - U.S. Food and Drug Administration, 10903 New Hampshire Avenue (WO 62), Silver Spring, MD 20993, USA, pras.pathmanathan@fda.hhs.gov Y1 - 2015/01// PY - 2015 DA - January 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Ventricle KW - Fibrillation KW - Animal models KW - Waves KW - Filaments KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746894458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Filament+Dynamics+during+Simulated+Ventricular+Fibrillation+in+a+High-Resolution+Rabbit+Heart&rft.au=Pathmanathan%2C+Pras%3BGray%2C+Richard+A&rft.aulast=Pathmanathan&rft.aufirst=Pras&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F720575 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 1 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Heart; Ventricle; Fibrillation; Animal models; Waves; Filaments; Models DO - http://dx.doi.org/10.1155/2015/720575 ER - TY - JOUR T1 - Quantitation of viable Coxiella burnetii in milk using an integrated cell culture-polymerase chain reaction (ICC-PCR) assay AN - 1746885187; PQ0002258347 AB - The obligate intracellular pathogen Coxiella burnetii has long been considered the most heat resistant pathogen in raw milk, making it the reference pathogen for determining pasteurisation conditions for milk products. New milk formulations and novel non-thermal processes require validation of effectiveness which requires a more practical method for analysis than using the currently used animal model for assessing Coxiella survival. Also, there is an interest in better characterising thermal inactivation of Coxiella in various milk formulations. To avoid the use of the guinea pig model for evaluating Coxiella survival, an Integrated Cell Culture-PCR (ICC-PCR) method was developed for determining Coxiella viability in milk. Vero cell cultures were directly infected from Coxiella-contaminated milk in duplicate 24-well plates. Viability of the Coxiella in milk was shown by a greater than or equal to 0.5 log genome equivalent (ge)/ml increase in the quantity of IS111a gene from the baseline post-infection (day 0) level after 9-11 d propagation. Coxiella in skim, 2%, and whole milk, and half and half successfully infected Vero cells and increased in number by at least 2 logs using a 48-h infection period followed by 9-d propagation time. As few as 125 Coxiella ge/ml in whole milk was shown to infect and propagate at least 2 logs in the optimised ICC-PCR assay, though variable confirmation of propagation was shown for as low as 25 Coxiella ge/ml. Applicability of the ICC-PCR method was further proven in an MPN format to quantitate the number of viable Coxiella remaining in whole milk after 60 degree C thermal treatment at 0, 20, 40, 60 and 90 min. JF - Journal of Dairy Research AU - Stewart, Diana AU - Shieh, Y-Carol AU - Tortorello, Mary AU - Kukreja, Ankush AU - Shazer, Arlette AU - Schlesser, Joseph AD - US Food and Drug Administration, Division of Food Processing Science & Technology, Bedford Park, IL 60501, USA, diana.stewart@fda.hhs.gov PY - 2015 SP - 478 EP - 484 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 82 IS - 4 SN - 0022-0299, 0022-0299 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Genomes KW - Vero cells KW - Animal models KW - Cell culture KW - Pathogens KW - Infection KW - Pasteurization KW - Coxiella burnetii KW - Milk products KW - Heat KW - Quantitation KW - X 24320:Food Additives & Contaminants KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746885187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Dairy+Research&rft.atitle=Quantitation+of+viable+Coxiella+burnetii+in+milk+using+an+integrated+cell+culture-polymerase+chain+reaction+%28ICC-PCR%29+assay&rft.au=Stewart%2C+Diana%3BShieh%2C+Y-Carol%3BTortorello%2C+Mary%3BKukreja%2C+Ankush%3BShazer%2C+Arlette%3BSchlesser%2C+Joseph&rft.aulast=Stewart&rft.aufirst=Diana&rft.date=2015-01-01&rft.volume=82&rft.issue=4&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Journal+of+Dairy+Research&rft.issn=00220299&rft_id=info:doi/10.1017%2FS0022029915000400 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 20 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Genomes; Cell survival; Milk products; Vero cells; Heat; Animal models; Cell culture; Pathogens; Infection; Quantitation; Pasteurization; Coxiella burnetii DO - http://dx.doi.org/10.1017/S0022029915000400 ER - TY - JOUR T1 - Blood Pyrrole-Protein Adducts--A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans. AN - 1738818900; 26398275 AB - Pyrrolizidine alkaloids (PAs) induce liver injury (PA-ILI) and is very likely to contribute significantly to drug-induced liver injury (DILI). In this study we used a newly developed ultra-high performance liquid chromatography-triple quadrupole-mass spectrometry (UHPLC-MS)-based method to detect and quantitate blood pyrrole-protein adducts in DILI patients. Among the 46 suspected DILI patients, 15 were identified as PA-ILI by the identification of PA-containing herbs exposed. Blood pyrrole-protein adducts were detected in all PA-ILI patients (100%). These results confirm that PA-ILI is one of the major causes of DILI and that blood pyrrole-protein adducts quantitated by the newly developed UHPLC-MS method can serve as a specific biomarker of PA-ILI. JF - Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews AU - Ruan, Jianqing AU - Gao, Hong AU - Li, Na AU - Xue, Junyi AU - Chen, Jie AU - Ke, Changqiang AU - Ye, Yang AU - Fu, Peter Pi-Cheng AU - Zheng, Jiang AU - Wang, Jiyao AU - Lin, Ge AD - a School of Biomedical Sciences, Faculty of Medicine , The Chinese University of Hong Kong , Hong Kong SAR , Hong Kong. ; b Division of Gastroenterology, Zhongshan Hospital , Fudan University , Shanghai , P. R. China. ; c Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica , Chinese Academy of Sciences and The Chinese University of Hong Kong , Hong Kong SAR , Hong Kong. ; e National Center for Toxicological Research , Jefferson , Arkansas , USA. ; f Center for Developmental Therapeutics, Seattle Children's Research Institute, Division of Gastroenterology, Department of Pediatrics , University of Washington , Washington , USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 404 EP - 421 VL - 33 IS - 4 KW - Biomarkers KW - 0 KW - Pyrroles KW - Pyrrolizidine Alkaloids KW - Toxins, Biological KW - Index Medicus KW - pyrrolizidine alkaloids KW - hepatic sinusoidal obstruction syndrome KW - pyrrole-protein adducts KW - hepatotoxicity KW - Animals KW - Humans KW - Aged KW - Chromatography, High Pressure Liquid KW - Toxins, Biological -- metabolism KW - Rats KW - Toxins, Biological -- chemistry KW - Adult KW - Toxicity Tests KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Pyrrolizidine Alkaloids -- blood KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Pyrroles -- blood KW - Pyrroles -- chemistry KW - Pyrrolizidine Alkaloids -- metabolism KW - Hepatic Veno-Occlusive Disease -- blood KW - Biomarkers -- blood KW - Pyrrolizidine Alkaloids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738818900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.atitle=Blood+Pyrrole-Protein+Adducts--A+Biomarker+of+Pyrrolizidine+Alkaloid-Induced+Liver+Injury+in+Humans.&rft.au=Ruan%2C+Jianqing%3BGao%2C+Hong%3BLi%2C+Na%3BXue%2C+Junyi%3BChen%2C+Jie%3BKe%2C+Changqiang%3BYe%2C+Yang%3BFu%2C+Peter+Pi-Cheng%3BZheng%2C+Jiang%3BWang%2C+Jiyao%3BLin%2C+Ge&rft.aulast=Ruan&rft.aufirst=Jianqing&rft.date=2015-01-01&rft.volume=33&rft.issue=4&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.issn=1532-4095&rft_id=info:doi/10.1080%2F10590501.2015.1096882 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-09 N1 - Date created - 2015-12-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/10590501.2015.1096882 ER - TY - JOUR T1 - The Global Landscape of Occupational Exposure Limits--Implementation of Harmonization Principles to Guide Limit Selection. AN - 1736414401; 26099071 AB - Occupational exposure limits (OELs) serve as health-based benchmarks against which measured or estimated workplace exposures can be compared. In the years since the introduction of OELs to public health practice, both developed and developing countries have established processes for deriving, setting, and using OELs to protect workers exposed to hazardous chemicals. These processes vary widely, however, and have thus resulted in a confusing international landscape for identifying and applying such limits in workplaces. The occupational hygienist will encounter significant overlap in coverage among organizations for many chemicals, while other important chemicals have OELs developed by few, if any, organizations. Where multiple organizations have published an OEL, the derived value often varies considerably-reflecting differences in both risk policy and risk assessment methodology as well as access to available pertinent data. This article explores the underlying reasons for variability in OELs, and recommends the harmonization of risk-based methods used by OEL-deriving organizations. A framework is also proposed for the identification and systematic evaluation of OEL resources, which occupational hygienists can use to support risk characterization and risk management decisions in situations where multiple potentially relevant OELs exist. JF - Journal of occupational and environmental hygiene AU - Deveau, M AU - Chen, C-P AU - Johanson, G AU - Krewski, D AU - Maier, A AU - Niven, K J AU - Ripple, S AU - Schulte, P A AU - Silk, J AU - Urbanus, J H AU - Zalk, D M AU - Niemeier, R W AD - a McLaughlin Centre for Population Health Risk Assessment, University of Ottawa , Ottawa , Ontario , Canada. ; c Department of Occupational Safety and Health, College of Public Health, China Medical University , Taichung , Taiwan. ; d Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet , Stockholm , Sweden. ; e Department of Environmental Health, College of Medicine, University of Cincinnati , Cincinnati , Ohio. ; f Shell Health, Shell International B.V. , The Hague , The Netherlands. ; g Global Industrial Hygiene Expertise Center, The Dow Chemical Company , Midland , Michigan. ; h Education and Information Division, National Institute for Occupational Safety and Health , Cincinnati , Ohio. ; i Directorate of Standards and Guidance, Occupational Safety and Health Administration , Washington, DC (Retired). ; j ES&H Directorate, Lawrence Livermore National Laboratory , Livermore , California. ; k Education and Information Division, National Institute for Occupational Safety and Health , Cincinnati , Ohio. Y1 - 2015 PY - 2015 DA - 2015 SP - S127 EP - S144 VL - 12 Suppl 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - harmonization KW - risk policy KW - risk science KW - occupational exposure limit KW - Occupational Health KW - International Cooperation KW - Humans KW - Risk Management KW - Hazardous Substances -- toxicity KW - Threshold Limit Values KW - Occupational Exposure -- prevention & control KW - Occupational Exposure -- standards KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736414401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=The+Global+Landscape+of+Occupational+Exposure+Limits--Implementation+of+Harmonization+Principles+to+Guide+Limit+Selection.&rft.au=Deveau%2C+M%3BChen%2C+C-P%3BJohanson%2C+G%3BKrewski%2C+D%3BMaier%2C+A%3BNiven%2C+K+J%3BRipple%2C+S%3BSchulte%2C+P+A%3BSilk%2C+J%3BUrbanus%2C+J+H%3BZalk%2C+D+M%3BNiemeier%2C+R+W&rft.aulast=Deveau&rft.aufirst=M&rft.date=2015-01-01&rft.volume=12+Suppl+1&rft.issue=&rft.spage=S127&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1060327 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-23 N1 - Date created - 2015-11-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Toxicol Environ Health B Crit Rev. 2010 Oct;13(7-8):546-78 [21170809] Regul Toxicol Pharmacol. 2010 Nov;58(2):323-9 [20655351] J Toxicol Environ Health A. 2011;74(2-4):261-85 [21218351] Crit Rev Toxicol. 2010 Oct;40(9):791-8 [20860525] Crit Rev Toxicol. 2010 Sep;40(8):671-96 [20722583] Int J Occup Environ Health. 2010 Jul-Sep;16(3):249-62 [20662417] Ind Health. 2010;48(1):18-28 [20160404] Toxicol Appl Pharmacol. 2008 Nov 15;233(1):71-5 [19013305] J Appl Toxicol. 2008 Oct;28(7):858-66 [18381691] Regul Toxicol Pharmacol. 2008 Aug;51(3):253-69 [18502550] J Occup Environ Hyg. 2008 May;5(5):330-46 [18350442] Regul Toxicol Pharmacol. 2008 Mar;50(2):261-70 [18226844] J Occup Environ Hyg. 2015;12 Suppl 1:S55-68 [26097979] J Occup Environ Hyg. 2015;12 Suppl 1:S7-17 [26252067] J Occup Environ Hyg. 2015;12 Suppl 1:S99-111 [26302336] Regul Toxicol Pharmacol. 2001 Oct;34(2):153-69 [11603958] Environ Health Perspect. 2014 Aug;122(8):796-805 [24727499] Toxicology. 2013 Nov 16;313(2-3):160-73 [23219588] Regul Toxicol Pharmacol. 2013 Jul;66(2):241-7 [23579077] Ann Occup Hyg. 2012 Jul;56(5):506-14 [22752095] Ann Occup Hyg. 2012 Jul;56(5):525-41 [22267129] Regul Toxicol Pharmacol. 2011 Dec;61(3):296-309 [21907258] Regul Toxicol Pharmacol. 2011 Oct;61(1):63-72 [21712060] Toxicol Sci. 2011 Jun;121(2):408-16 [21389111] Regul Toxicol Pharmacol. 2002 Dec;36(3):262-79 [12473411] Regul Toxicol Pharmacol. 1983 Sep;3(3):224-38 [6356243] Am J Ind Med. 1988;13(5):531-59 [3287906] Regul Toxicol Pharmacol. 1991 Jun;13(3):241-62 [1682974] Ann Occup Hyg. 1991 Dec;35(6):569-80 [1768007] Toxicol Lett. 1992 Dec;64-65 Spec No:53-7 [1471206] Toxicol Lett. 1995 May;77(1-3):183-7 [7618133] Regul Toxicol Pharmacol. 1997 Feb;25(1):1-5 [9056496] Regul Toxicol Pharmacol. 1997 Apr;25(2):121-9 [9185888] Toxicol Sci. 2005 Aug;86(2):226-30 [15829616] Regul Toxicol Pharmacol. 2005 Oct;43(1):1-9 [16099564] J Toxicol Environ Health B Crit Rev. 2007 Oct;10(7):527-57 [17934949] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2015.1060327 ER - TY - JOUR T1 - Evaluation of CYP3A4 inhibition and hepatotoxicity using DMSO-treated human hepatoma HuH-7 cells AN - 1735926868; PQ0002282656 AB - A human hepatoma cell line (HuH-7) was evaluated as a metabolically competent cell model to investigate cytochrome P450 3A4 (CYP3A4) inhibition, induction, and hepatotoxicity. First, CYP3A4 gene expression and activity were determined in HuH-7 cells under three culture conditions: 1-week culture, 3-week culture, or 1 % dimethyl sulfoxide (DMSO) treatment. HuH-7 cells treated with DMSO for 2 weeks after confluence expressed the highest CYP3A4 gene expression and activity compared to the other two culture conditions. Furthermore, CYP3A4 activity in DMSO-treated HuH-7 cells was compared to that in a human hepatoma cell line (HepG2/C3A) and human bipotent progenitor cell line (HepaRG), which yielded the following ranking: HepaRG > DMSO-treated HuH-7 >> HepG2/C3A cells. The effects of three known CYP3A4 inhibitors were evaluated using DMSO-treated HuH-7 cells. CYP3A4 enzyme inhibition in HuH-7 cells was further compared to human recombinant CYP3A4, indicating similar potency for reversible inhibitors (IC sub(50) within 2.5-fold), but different potency for the irreversible inhibitor. Next, induction of CYP3A4 activity was compared between DMSO-treated HuH-7 and HepaRG cells using two known inducers. DMSO-treated HuH-7 cells yielded minimal CYP3A4 induction compared to that in the HepaRG cells after 48-h treatments. Finally, the cytotoxicity of five known hepatotoxicants was evaluated in DMSO-treated HuH-7, HepG2/C3A, and HepaRG cells, and significant differences in cytotoxic sensitivity were observed. Overall, DMSO-treated HuH-7 cells are a valuable model for medium- or high-throughput screening of chemicals for CYP3A4 inhibition and hepatotoxicity. JF - Cell Biology and Toxicology AU - Liu, Yitong AU - Flynn, Thomas J AU - Xia, Menghang AU - Wiesenfeld, Paddy L AU - Ferguson, Martine S AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA, yitong.liu@fda.hhs.gov PY - 2015 SP - 221 EP - 230 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 31 IS - 4-5 SN - 0742-2091, 0742-2091 KW - Toxicology Abstracts KW - Hepatoma KW - CYP3A4 gene KW - Cytotoxicity KW - Stem cells KW - Dimethyl sulfoxide KW - Enzymes KW - Cell culture KW - high-throughput screening KW - Cytochrome P450 KW - hepatotoxicity KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735926868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Biology+and+Toxicology&rft.atitle=Evaluation+of+CYP3A4+inhibition+and+hepatotoxicity+using+DMSO-treated+human+hepatoma+HuH-7+cells&rft.au=Liu%2C+Yitong%3BFlynn%2C+Thomas+J%3BXia%2C+Menghang%3BWiesenfeld%2C+Paddy+L%3BFerguson%2C+Martine+S&rft.aulast=Liu&rft.aufirst=Yitong&rft.date=2015-01-01&rft.volume=31&rft.issue=4-5&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Cell+Biology+and+Toxicology&rft.issn=07422091&rft_id=info:doi/10.1007%2Fs10565-015-9306-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Number of references - 31 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - CYP3A4 gene; Hepatoma; Stem cells; Cytotoxicity; Dimethyl sulfoxide; Enzymes; high-throughput screening; Cell culture; Cytochrome P450; hepatotoxicity DO - http://dx.doi.org/10.1007/s10565-015-9306-9 ER - TY - JOUR T1 - Predictive biomarkers for treatment selection: statistical considerations. AN - 1734283235; 26507127 AB - Predictive biomarkers are developed for treatment selection to identify patients who are likely to benefit from a particular therapy. This review describes statistical methods and discusses issues in the development of predictive biomarkers to enhance study efficiency for detection of treatment effect on the selected responder patients in clinical studies. The statistical procedure for treatment selection consists of three components: biomarker identification, subgroup selection and clinical utility assessment. Major statistical issues discussed include biomarker designs, procedures to identify predictive biomarkers, classification models for subgroup selection, subgroup analysis and multiple testing for clinical utility assessment and evaluation. JF - Biomarkers in medicine AU - Chen, James J AU - Lu, Tzu-Pin AU - Chen, Yu-Chuan AU - Lin, Wei-Jiun AD - Division of Bioinformatics & Biostatistics, National Center for Toxicological Research, US Food & Drug Administration, Jefferson, AR 72079, USA. ; Department of Public Health, Institute of Epidemiology & Preventive Medicine, National Taiwan University, Taipei, Taiwan. ; Department of Applied Mathematics, Feng Chia University, Taichung, Taiwan. Y1 - 2015 PY - 2015 DA - 2015 SP - 1121 EP - 1135 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - Index Medicus KW - subgroup selection KW - predictive biomarker KW - personalized and precision medicine KW - subgroup analysis KW - predictive classifier KW - biomarker adaptive design KW - Humans KW - Safety KW - Therapeutics KW - Biomarkers -- analysis KW - Biostatistics -- methods KW - Decision Making UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734283235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Predictive+biomarkers+for+treatment+selection%3A+statistical+considerations.&rft.au=Chen%2C+James+J%3BLu%2C+Tzu-Pin%3BChen%2C+Yu-Chuan%3BLin%2C+Wei-Jiun&rft.aulast=Chen&rft.aufirst=James&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1121&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.84 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.84 ER - TY - JOUR T1 - microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment. AN - 1734282106; 26501795 AB - Much evidence has documented that microRNAs (miRNAs) play an important role in the modulation of interindividual variability in the production of drug metabolizing enzymes and transporters (DMETs) and nuclear receptors (NRs) through multidirectional interactions involving environmental stimuli/stressors, the expression of miRNA molecules and genetic polymorphisms. MiRNA expression has been reported to be affected by drugs and miRNAs themselves may affect drug metabolism and toxicity. In cancer research, miRNA biomarkers have been identified to mediate intrinsic and acquired resistance to cancer therapies. In drug safety assessment, miRNAs have been found associated with cardiotoxicity, hepatotoxicity and nephrotoxicity. This review article summarizes published studies to show that miRNAs can serve as early biomarkers for the evaluation of drug efficacy and drug safety. JF - Biomarkers in medicine AU - Koturbash, Igor AU - Tolleson, William H AU - Guo, Lei AU - Yu, Dianke AU - Chen, Si AU - Hong, Huixiao AU - Mattes, William AU - Ning, Baitang AD - Department of Environmental & Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. ; National Center for Toxicological Research, US Food & Drug Administration, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1153 EP - 1176 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - MicroRNAs KW - Index Medicus KW - nephrotoxicity KW - drug efficacy KW - biomarker KW - drug metabolizing enzymes KW - cardiotoxicity KW - microRNA KW - hepatotoxicity KW - drug safety KW - Animals KW - Humans KW - Drug Resistance, Neoplasm -- genetics KW - Biomarkers -- metabolism KW - MicroRNAs -- genetics KW - Safety KW - Pharmacogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734282106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=microRNAs+as+pharmacogenomic+biomarkers+for+drug+efficacy+and+drug+safety+assessment.&rft.au=Koturbash%2C+Igor%3BTolleson%2C+William+H%3BGuo%2C+Lei%3BYu%2C+Dianke%3BChen%2C+Si%3BHong%2C+Huixiao%3BMattes%2C+William%3BNing%2C+Baitang&rft.aulast=Koturbash&rft.aufirst=Igor&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1153&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.89 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.89 ER - TY - JOUR T1 - Biomarker-based drug safety assessment in the age of systems pharmacology: from foundational to regulatory science. AN - 1734282105; 26506997 AB - Improved biomarker-based assessment of drug safety is needed in drug discovery and development as well as regulatory evaluation. However, identifying drug safety-related biomarkers such as genes, proteins, miRNA and single-nucleotide polymorphisms remains a big challenge. The advances of 'omics' and computational technologies such as genomics, transcriptomics, metabolomics, proteomics, systems biology, network biology and systems pharmacology enable us to explore drug actions at the organ and organismal levels. Computational and experimental systems pharmacology approaches could be utilized to facilitate biomarker-based drug safety assessment for drug discovery and development and to inform better regulatory decisions. In this article, we review the current status and advances of systems pharmacology approaches for the development of predictive models to identify biomarkers for drug safety assessment. JF - Biomarkers in medicine AU - Zhang, Chen AU - Hong, Huixiao AU - Mendrick, Donna L AU - Tang, Yun AU - Cheng, Feixiong AD - Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China. ; National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1241 EP - 1252 VL - 9 IS - 11 KW - Biomarkers, Pharmacological KW - 0 KW - Pharmaceutical Preparations KW - Index Medicus KW - biomarker KW - systems biology KW - drug safety assessment KW - systems pharmacology KW - regulatory science KW - Animals KW - Humans KW - Biomarkers, Pharmacological -- metabolism KW - Systems Biology -- methods KW - Pharmacology -- methods KW - Social Control, Formal KW - Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734282105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Biomarker-based+drug+safety+assessment+in+the+age+of+systems+pharmacology%3A+from+foundational+to+regulatory+science.&rft.au=Zhang%2C+Chen%3BHong%2C+Huixiao%3BMendrick%2C+Donna+L%3BTang%2C+Yun%3BCheng%2C+Feixiong&rft.aulast=Zhang&rft.aufirst=Chen&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1241&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.81 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.81 ER - TY - JOUR T1 - Translating extracellular microRNA into clinical biomarkers for drug-induced toxicity: from high-throughput profiling to validation. AN - 1734282075; 26501984 AB - Over the past 5 years, extracellular microRNAs (miRNAs) are being vigorously explored as injury biomarkers, including drug-induced cardiotoxicity, hepatotoxicity and nephrotoxicity. Currently, the development of miRNAs as clinical biomarkers has been hindered by the lack of standardization. Therefore, extracellular miRNA-based biomarkers have not been embraced as diagnostic tools. Each platform has its strengths and weaknesses when working with low-input-amount RNA samples from body fluids; the selection of a miRNA quantification approach should be based on the study design. The following review provides a summary of the extracellular miRNA release and stability in body fluids, performances of different miRNA quantification platforms, existing clinical gold standards for drug-induced tissue damage and translation of the miRNA biomarkers from the nonclinical to clinical setting. JF - Biomarkers in medicine AU - Wang, Wenjun AU - Shi, Qiang AU - Mattes, Williams B AU - Mendrick, Donna L AU - Yang, Xi AD - College of Life Science, South-Central University for Nationalities, Wuhan 430074, PR China. ; Division of Systems Biology, National Center for Toxicological Research, Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1177 EP - 1188 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - MicroRNAs KW - Index Medicus KW - nephrotoxicity KW - extracellular KW - cardiotoxicity KW - microRNA KW - biomarkers KW - hepatotoxicity KW - Biomarkers -- chemistry KW - Animals KW - Reproducibility of Results KW - Humans KW - Biomarkers -- metabolism KW - MicroRNAs -- metabolism KW - Extracellular Space -- metabolism KW - Drug-Related Side Effects and Adverse Reactions -- pathology KW - MicroRNAs -- biosynthesis KW - MicroRNAs -- chemistry KW - Translational Medical Research -- methods KW - Drug-Related Side Effects and Adverse Reactions -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734282075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Translating+extracellular+microRNA+into+clinical+biomarkers+for+drug-induced+toxicity%3A+from+high-throughput+profiling+to+validation.&rft.au=Wang%2C+Wenjun%3BShi%2C+Qiang%3BMattes%2C+Williams+B%3BMendrick%2C+Donna+L%3BYang%2C+Xi&rft.aulast=Wang&rft.aufirst=Wenjun&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1177&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.86 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.86 ER - TY - JOUR T1 - Ionotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkers. AN - 1734281936; 26508561 AB - Antagonism of ionotropic GABA receptors (iGABARs) can occur at three distinct types of receptor binding sites causing chemically induced epileptic seizures. Here we review three adverse outcome pathways, each characterized by a specific molecular initiating event where an antagonist competitively binds to active sites, negatively modulates allosteric sites or noncompetitively blocks ion channel on the iGABAR. This leads to decreased chloride conductance, followed by depolarization of affected neurons, epilepsy-related death and ultimately decreased population. Supporting evidence for causal linkages from the molecular to population levels is presented and differential sensitivity to iGABAR antagonists in different GABA receptors and organisms discussed. Adverse outcome pathways are poised to become important tools for linking mechanism-based biomarkers to regulated outcomes in next-generation risk assessment. JF - Biomarkers in medicine AU - Gong, Ping AU - Hong, Huixiao AU - Perkins, Edward J AD - Environmental Laboratory, US Army Engineer Research & Development Center, 3909 Halls Ferry Road, Vicksburg, MS 39180, USA. ; Division of Bioinformatics & Biostatistics, National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1225 EP - 1239 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - GABA Antagonists KW - Receptors, GABA KW - Index Medicus KW - neurotoxicity biomarker KW - ionotropic γ-aminobutyric acid receptor KW - neurotransmission KW - metabotropic GABA receptor KW - chloride channel KW - risk assessment KW - epileptic seizure KW - cross-species extrapolation KW - antagonist KW - adverse outcome pathway KW - Animals KW - Humans KW - Receptors, GABA -- metabolism KW - Nervous System -- drug effects KW - GABA Antagonists -- adverse effects KW - Nervous System -- metabolism KW - Biomarkers -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734281936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Ionotropic+GABA+receptor+antagonism-induced+adverse+outcome+pathways+for+potential+neurotoxicity+biomarkers.&rft.au=Gong%2C+Ping%3BHong%2C+Huixiao%3BPerkins%2C+Edward+J&rft.aulast=Gong&rft.aufirst=Ping&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.58 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.58 ER - TY - JOUR T1 - Circulating mitochondrial biomarkers for drug-induced liver injury. AN - 1734281872; 26507261 AB - Liver mitochondria affected by drugs can be released into circulation and serve as biomarkers for drug-induced liver injury (DILI). The tissue specificity of ALT was improved by differentiating cytosolic ALT1 and mitochondrial ALT2 isoforms released in circulation. Prior to ALT elevation, mitochondrial cytochrome c, OCT, GLDH, CPS1 and DNA were increased in circulation following DILI. The baseline expression of mt-Nd6 was predictive of individual DILI susceptibility in animals. As mitochondrial DILI biomarkers appeared to be drug or species dependent, they might have value in clinical scenarios when culprit drugs are established, but may not be ideal tools to assess DILI potentials of new drugs. JF - Biomarkers in medicine AU - Shi, Qiang AU - Yang, Xi AU - Mattes, William B AU - Mendrick, Donna L AU - Harrill, Alison H AU - Beger, Richard D AD - Division of Systems Biology, National Center for Toxicological Research, Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Regulatory Activities, National Center for Toxicological Research, Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Department of Environmental & Occupational Health, The University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1215 EP - 1223 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - Mitochondrial Proteins KW - Index Medicus KW - biomarker KW - mitochondrion KW - acetaminophen KW - drug-induced liver injury KW - hepatotoxicity KW - Animals KW - Humans KW - Mitochondrial Proteins -- blood KW - Metabolomics KW - Genomics KW - Chemical and Drug Induced Liver Injury -- blood KW - Chemical and Drug Induced Liver Injury -- pathology KW - Chemical and Drug Induced Liver Injury -- genetics KW - Mitochondria -- metabolism KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Biomarkers -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734281872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Circulating+mitochondrial+biomarkers+for+drug-induced+liver+injury.&rft.au=Shi%2C+Qiang%3BYang%2C+Xi%3BMattes%2C+William+B%3BMendrick%2C+Donna+L%3BHarrill%2C+Alison+H%3BBeger%2C+Richard+D&rft.aulast=Shi&rft.aufirst=Qiang&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1215&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.59 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.59 ER - TY - JOUR T1 - NETBAGs: a network-based clustering approach with gene signatures for cancer subtyping analysis. AN - 1734281766; 26501477 AB - To evaluate gene signature and network-based approach for cancer subtyping and classification. Here we introduced NETwork Based clustering Approach with Gene signatures (NETBAGs) algorithm, which clustered samples based on gene signatures and identified molecular markers based on their significantly expressed gene network profiles. Applying NETBAGs to multiple independent breast cancer datasets, we demonstrated that the clustering results were highly associated with the clinical subtypes and clearly revealed the genomic diversity of breast cancer samples. NETBAGs algorithm is able to classify samples by their genomic signatures into clinically significant phenotypes so that potential biomarkers can be identified. The approach may contribute to cancer research and clinical study of complex diseases. JF - Biomarkers in medicine AU - Wu, Leihong AU - Liu, Zhichao AU - Xu, Joshua AU - Chen, Minjun AU - Fang, Hong AU - Tong, Weida AU - Xiao, Wenming AD - Division of Bioinformatics & Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Office of Scientific Coordination, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1053 EP - 1065 VL - 9 IS - 11 KW - ERBB2 protein, human KW - EC 2.7.10.1 KW - Receptor, ErbB-2 KW - Index Medicus KW - expression KW - RNA-seq KW - cancer subtyping KW - cluster KW - gene network KW - microarray KW - Triple Negative Breast Neoplasms -- diagnosis KW - Genetic Variation KW - Gene Expression Profiling KW - Triple Negative Breast Neoplasms -- classification KW - Receptor, ErbB-2 -- metabolism KW - Triple Negative Breast Neoplasms -- genetics KW - Humans KW - Prognosis KW - Algorithms KW - Cluster Analysis KW - Genomics KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- diagnosis KW - Gene Regulatory Networks KW - Computational Biology -- methods KW - Breast Neoplasms -- metabolism KW - Breast Neoplasms -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734281766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=NETBAGs%3A+a+network-based+clustering+approach+with+gene+signatures+for+cancer+subtyping+analysis.&rft.au=Wu%2C+Leihong%3BLiu%2C+Zhichao%3BXu%2C+Joshua%3BChen%2C+Minjun%3BFang%2C+Hong%3BTong%2C+Weida%3BXiao%2C+Wenming&rft.aulast=Wu&rft.aufirst=Leihong&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1053&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.96 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.96 ER - TY - JOUR T1 - Biomarker identification from next-generation sequencing data for pathogen bacteria characterization and surveillance. AN - 1734281647; 26501894 AB - The purpose was to develop an analytical pipeline for specific gene analysis and biomarker discovery from next generation sequencing (NGS) data. As a test case, the fliC gene reference sequences of 24 Salmonella enterica strains of 13 serotypes and NGS reads of 32 serovar Newport, 48 Montevideo and 115 Enteritidis outbreak isolates were retrieved from the National Center for Biotechnology Information database. Establishment of an analytical pipeline consisting of four steps: reference sequences retrieval and template sequence determination; NGS sequence reads retrieval; multiple sequence alignments and phylogenetic analysis; data mining and biomarker discovery. The pipeline developed provides an effective bioinformatics tool for genetic diversity clarification and marker sequences discovery for pathogen characterization and surveillance. JF - Biomarkers in medicine AU - Zhao, Weizhong AU - Chen, James J AU - Foley, Steven AU - Wang, Yuping AU - Zhao, Shaohua AU - Basinger, John AU - Zou, Wen AD - Division of Bioinformatics & Biostatistics, National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA. ; Division of Microbiology, National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA. ; Division of Animal & Food Microbiology, Office of Research, Center for Veterinary Medicine, US Food & Drug Administration, Laurel, MD 20993, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1253 EP - 1264 VL - 9 IS - 11 KW - Bacterial Proteins KW - 0 KW - Biomarkers KW - Index Medicus KW - Salmonella serotypes KW - biomarker KW - bioinformatics pipeline KW - gene diversity KW - next-generation sequencing analysis KW - fliC gene KW - Phylogeny KW - Bacterial Proteins -- genetics KW - Humans KW - Genomics KW - Salmonella enterica -- isolation & purification KW - Salmonella enterica -- genetics KW - Biomarkers -- metabolism KW - Salmonella enterica -- metabolism KW - High-Throughput Nucleotide Sequencing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734281647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Biomarker+identification+from+next-generation+sequencing+data+for+pathogen+bacteria+characterization+and+surveillance.&rft.au=Zhao%2C+Weizhong%3BChen%2C+James+J%3BFoley%2C+Steven%3BWang%2C+Yuping%3BZhao%2C+Shaohua%3BBasinger%2C+John%3BZou%2C+Wen&rft.aulast=Zhao&rft.aufirst=Weizhong&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1253&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.88 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.88 ER - TY - JOUR T1 - Molecular regulation of miRNAs and potential biomarkers in the progression of hepatic steatosis to NASH. AN - 1734281488; 26506944 AB - Increasing evidence suggests that microRNAs regulate diverse biological functions in the liver and play a very important function in metabolic-related disorders such as nonalcoholic fatty liver disease via regulating their target genes expression. In this review, we summarized the most recent progress in identification of miRNAs involving in the progression of liver steatosis and discussed the possible mechanisms by which miRNAs contribute to the diverse pathogenic liver injuries. We provide insights into the functional network of miRNAs by connecting miRNAs, their targets and biological pathways associated to hepatic steatosis and fibrosis, with important implications for our understanding of phenotypic-based disease pathogenesis. We also discuss the possible roles and challenges of miRNAs as biomarkers for drug-induced liver injury. JF - Biomarkers in medicine AU - Wang, Yuping AU - Liu, Zhichao AU - Zou, Wen AU - Hong, Huixiao AU - Fang, Hong AU - Tong, Weida AD - Division of Bioinformatics & Biostatistics, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Office of Scientific Coordination, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1189 EP - 1200 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - MicroRNAs KW - Peroxisome Proliferator-Activated Receptors KW - Index Medicus KW - biomarker KW - drug-induced liver disease KW - steatosis KW - miRNA KW - nonalcoholic fatty liver disease KW - fibrosis KW - steatohepatitis KW - Liver Cirrhosis -- pathology KW - Animals KW - Humans KW - Liver Cirrhosis -- metabolism KW - Biomarkers -- metabolism KW - Peroxisome Proliferator-Activated Receptors -- metabolism KW - Liver Cirrhosis -- genetics KW - Non-alcoholic Fatty Liver Disease -- genetics KW - Non-alcoholic Fatty Liver Disease -- metabolism KW - MicroRNAs -- metabolism KW - MicroRNAs -- genetics KW - Disease Progression KW - Non-alcoholic Fatty Liver Disease -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734281488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Molecular+regulation+of+miRNAs+and+potential+biomarkers+in+the+progression+of+hepatic+steatosis+to+NASH.&rft.au=Wang%2C+Yuping%3BLiu%2C+Zhichao%3BZou%2C+Wen%3BHong%2C+Huixiao%3BFang%2C+Hong%3BTong%2C+Weida&rft.aulast=Wang&rft.aufirst=Yuping&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.70 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.70 ER - TY - JOUR T1 - HLADR: a database system for enhancing the discovery of biomarkers for predicting human leukocyte antigen-mediated idiosyncratic adverse drug reactions. AN - 1734280565; 26501190 AB - To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. Electronic databases were searched to extensively identify drug-HLA association studies from 1966 to present. A drug-HLA-IDR database, HLADR, was created. The drug-HLA relationship network clearly reflected an ethnicity dependency of the associations. The positive predictive values and the negative predictive values demonstrated that other potential factors may also regulate the occurrence of HLA-specific IDRs. Constructing studies with samples from homogeneous ethnic groups and identifying cofactors that affect negative predictive values and positive predictive values will become necessary to enhance the predictability of HLA biomarkers for future research on IDRs. JF - Biomarkers in medicine AU - Du, Tingting AU - Yang, Lun AU - Luo, Heng AU - Zhou, Peng AU - Mei, Hu AU - Xuan, Jiekun AU - Xing, Qinghe AU - Ning, Baitang AU - Mendrick, Donna L AU - Shi, Leming AD - Center for Pharmacogenomics & State Key Laboratory of Genetic Engineering, School of Life Sciences & School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China. ; National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Institutes of Biomedical Science, Fudan University, 138 Shanghai Medical School Road, Shanghai 200032, China. Y1 - 2015 PY - 2015 DA - 2015 SP - 1079 EP - 1093 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - HLA Antigens KW - Index Medicus KW - human leukocyte antigen KW - idiosyncratic drug reactions KW - pharmacogenomics KW - association KW - biomarkers KW - Alleles KW - Humans KW - Biomarkers -- metabolism KW - HLA Antigens -- genetics KW - Drug-Related Side Effects and Adverse Reactions -- genetics KW - Drug-Related Side Effects and Adverse Reactions -- diagnosis KW - Computational Biology -- methods KW - Databases, Factual KW - Drug-Related Side Effects and Adverse Reactions -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734280565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=HLADR%3A+a+database+system+for+enhancing+the+discovery+of+biomarkers+for+predicting+human+leukocyte+antigen-mediated+idiosyncratic+adverse+drug+reactions.&rft.au=Du%2C+Tingting%3BYang%2C+Lun%3BLuo%2C+Heng%3BZhou%2C+Peng%3BMei%2C+Hu%3BXuan%2C+Jiekun%3BXing%2C+Qinghe%3BNing%2C+Baitang%3BMendrick%2C+Donna+L%3BShi%2C+Leming&rft.aulast=Du&rft.aufirst=Tingting&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1079&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.98 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.98 ER - TY - JOUR T1 - The Scientific Basis of Uncertainty Factors Used in Setting Occupational Exposure Limits. AN - 1733188730; 26097979 AB - The uncertainty factor concept is integrated into health risk assessments for all aspects of public health practice, including by most organizations that derive occupational exposure limits. The use of uncertainty factors is predicated on the assumption that a sufficient reduction in exposure from those at the boundary for the onset of adverse effects will yield a safe exposure level for at least the great majority of the exposed population, including vulnerable subgroups. There are differences in the application of the uncertainty factor approach among groups that conduct occupational assessments; however, there are common areas of uncertainty which are considered by all or nearly all occupational exposure limit-setting organizations. Five key uncertainties that are often examined include interspecies variability in response when extrapolating from animal studies to humans, response variability in humans, uncertainty in estimating a no-effect level from a dose where effects were observed, extrapolation from shorter duration studies to a full life-time exposure, and other insufficiencies in the overall health effects database indicating that the most sensitive adverse effect may not have been evaluated. In addition, a modifying factor is used by some organizations to account for other remaining uncertainties-typically related to exposure scenarios or accounting for the interplay among the five areas noted above. Consideration of uncertainties in occupational exposure limit derivation is a systematic process whereby the factors applied are not arbitrary, although they are mathematically imprecise. As the scientific basis for uncertainty factor application has improved, default uncertainty factors are now used only in the absence of chemical-specific data, and the trend is to replace them with chemical-specific adjustment factors whenever possible. The increased application of scientific data in the development of uncertainty factors for individual chemicals also has the benefit of increasing the transparency of occupational exposure limit derivation. Improved characterization of the scientific basis for uncertainty factors has led to increasing rigor and transparency in their application as part of the overall occupational exposure limit derivation process. JF - Journal of occupational and environmental hygiene AU - Dankovic, D A AU - Naumann, B D AU - Maier, A AU - Dourson, M L AU - Levy, L S AD - a Education and Information Division, Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH) , Cincinnati , Ohio. ; b Global Safety and the Environment, Merck & Co., Inc., Whitehouse Station , New Jersey. ; c University of Cincinnati , College of Medicine, Department of Environmental Health, Cincinnati , Ohio. ; d The Toxicology Excellence for Risk Assessment Center of the University of Cincinnati, College of Medicine, Department of Environmental Health, Toxicology Excellence for Risk Assessment , Cincinnati , Ohio. ; e Institute for Environment, Health, Risks and Futures, Cranfield University, Cranfield, Bedfordshire. Y1 - 2015 PY - 2015 DA - 2015 SP - S55 EP - S68 VL - 12 Suppl 1 KW - Index Medicus KW - adjustment factor KW - uncertainty factor KW - risk assessment KW - occupational exposure KW - Uncertainty KW - Animals KW - No-Observed-Adverse-Effect Level KW - Humans KW - Species Specificity KW - Risk Assessment KW - Occupational Exposure -- standards KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1733188730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=The+Scientific+Basis+of+Uncertainty+Factors+Used+in+Setting+Occupational+Exposure+Limits.&rft.au=Dankovic%2C+D+A%3BNaumann%2C+B+D%3BMaier%2C+A%3BDourson%2C+M+L%3BLevy%2C+L+S&rft.aulast=Dankovic&rft.aufirst=D&rft.date=2015-01-01&rft.volume=12+Suppl+1&rft.issue=&rft.spage=S55&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1060325 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-23 N1 - Date created - 2015-11-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Risk Anal. 2000 Apr;20(2):245-50 [10859783] Ann Occup Hyg. 2007 Jun;51(4):345-56 [17602208] Regul Toxicol Pharmacol. 2002 Dec;36(3):262-79 [12473411] Risk Anal. 2003 Dec;23(6):1239-55 [14641898] Toxicol Appl Pharmacol. 1972 Apr;21(4):454-63 [5047046] Int Arch Occup Environ Health. 1979 Jan 15;42(3-4):191-201 [422260] Regul Toxicol Pharmacol. 1983 Sep;3(3):224-38 [6356243] J Appl Toxicol. 1984 Oct;4(5):277-80 [6512168] Regul Toxicol Pharmacol. 1985 Jun;5(2):190-6 [4023289] J Occup Med. 1986 Jun;28(6):425-33 [3723215] Regul Toxicol Pharmacol. 2008 Aug;51(3):253-69 [18502550] Toxicol Sci. 2009 Nov;112(1):196-210 [19692668] Crit Rev Toxicol. 2010 Oct;40(9):791-8 [20860525] Regul Toxicol Pharmacol. 2010 Nov;58(2):237-42 [20561553] Toxicol Sci. 2011 Sep;123(1):231-46 [21705714] Regul Toxicol Pharmacol. 2002 Jun;35(3):448-67 [12202058] Toxicol Lett. 2013 Apr 12;218(2):159-65 [23395978] J Occup Environ Hyg. 2015;12 Suppl 1:S7-17 [26252067] J Occup Environ Hyg. 2015;12 Suppl 1:S18-40 [26551218] J Occup Environ Hyg. 2015;12 Suppl 1:S127-44 [26099071] J Occup Environ Hyg. 2015;12 Suppl 1:S99-111 [26302336] J Occup Environ Hyg. 2015;12 Suppl 1:S69-81 [26583908] Regul Toxicol Pharmacol. 1986 Sep;6(3):211-37 [3775081] Risk Anal. 1987 Dec;7(4):415-26 [3444929] Am Ind Hyg Assoc J. 1988 Jun;49(6):309-13 [3400595] Ann Occup Hyg. 1989;33(4):555-62 [2690717] Regul Toxicol Pharmacol. 1990 Jun;11(3):314-30 [2196639] Food Addit Contam. 1991 Mar-Apr;8(2):135-49 [1868926] Toxicol Ind Health. 1992 May-Jun;8(3):171-89 [1502696] Regul Toxicol Pharmacol. 1992 Jun;15(3):291-306 [1509122] Toxicol Lett. 1992 Dec;64-65 Spec No:53-7 [1471206] Regul Toxicol Pharmacol. 1993 Feb;17(1):44-51 [8441828] Food Addit Contam. 1993 May-Jun;10(3):275-305 [8359312] J Toxicol Environ Health. 1995 May;45(1):83-95 [7538596] Regul Toxicol Pharmacol. 1996 Oct;24(2 Pt 1):108-20 [8933624] Risk Anal. 1998 Jun;18(3):271-82 [9664723] Occup Med (Lond). 1999 May;49(4):225-9 [10474913] Crit Rev Toxicol. 1999 Sep;29(5):439-90 [10521133] Environ Res. 2007 May;104(1):108-27 [17166493] Crit Rev Toxicol. 2007 Jun;37(5):355-73 [17612951] Regul Toxicol Pharmacol. 2012 Aug;63(3):461-70 [22683397] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2015.1060325 ER - TY - JOUR T1 - Detection by coupled LC-photodiode array detection and high-resolution Orbitrap MS of dimethyl and diethyl yellow dyes used illegally in processed soymilk curd AN - 1732815397; PQ0002209788 AB - An efficient non-target dye-screening system consisting of a liquid chromatography photodiode array coupled with a high-resolution mass spectrometer (HRMS) is described. Visible absorption spectroscopy assisted in locating the peak of an unknown dye in HRMS chromatograms which allowed the accurate molecular weight of the unknown to be obtained. In a study of the adulteration of processed soymilk curd (tofu) with dimethyl yellow, an unexpected unknown dye was discovered. The compound was further purified by gel permeation chromatography and identified by HRMS and proton nuclear magnetic resonance (NMR) as diethyl yellow (solvent yellow 56). This is the first time that diethyl yellow has been reported in foods. The authentic diethyl yellow was then purchased and used as a quantitative standard. Tofu products and their ingredients associated with tofu processing were surveyed. Analysis showed the source of diethyl yellow could be traced to emulsifiers used as ingredient in tofu products. Surveillance work found the concentrations of diethyl yellow ranged from several mu g kg super(-1) (ppb) in the tofu products to up to hundreds of mg kg super(-1) (ppm) in the emulsifiers. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Fang, Mingchih AU - Tsai, Chia-Fen AU - Kuo, Ching-Hao AU - Cheng, Hwei-Fang AD - Taiwan Food and Drug Administration, Taipei City, Taiwan PY - 2015 SP - 1730 EP - 1736 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 10 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Risk assessment KW - Food additives KW - Absorption spectroscopy KW - Dyes KW - Liquid chromatography KW - Chromatography KW - Solvents KW - NMR KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732815397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Detection+by+coupled+LC-photodiode+array+detection+and+high-resolution+Orbitrap+MS+of+dimethyl+and+diethyl+yellow+dyes+used+illegally+in+processed+soymilk+curd&rft.au=Fang%2C+Mingchih%3BTsai%2C+Chia-Fen%3BKuo%2C+Ching-Hao%3BCheng%2C+Hwei-Fang&rft.aulast=Fang&rft.aufirst=Mingchih&rft.date=2015-01-01&rft.volume=32&rft.issue=10&rft.spage=1730&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1055830 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Risk assessment; Absorption spectroscopy; Food additives; Dyes; Chromatography; Liquid chromatography; Solvents; NMR DO - http://dx.doi.org/10.1080/19440049.2015.1055830 ER - TY - JOUR T1 - Review of methods to measure internal contamination in an emergency AN - 1732810544; PQ0002108386 AB - In the event of a radiation emergency, people close to the site of the incident may be exposed to radiation by external exposure, or as a result of intakes of radioactive material. For these incidents it may be necessary to monitor members of the public both for external and internal contamination. This work reviews currently available equipment for the assessment of internal exposure following an emergency. It concentrates on incidents involving the spread of radioactive material and on contamination by radionuclides which emit penetrating radiation. It is essential that this monitoring is carried out as soon as possible so that people who have been exposed at a level which could have an effect on health can be identified and receive prompt medical assessment. Proposed action levels to identify people who need medical attention are reviewed to determine the required sensitivity of monitoring equipment. For releases containing gamma-ray emitting radionuclides the best means of measuring internal contamination is to use detectors placed close to the body (whole body or partial body monitoring). Laboratory based whole body monitors could be used but these may well be inconveniently located and so equipment which can be deployed to the site of an incident has been developed and these are described. The need for rapid selection and prioritisation of people for monitoring, methods to deal with potentially high numbers of contaminated people and the requirement for a means of rapidly interpreting monitoring information are also discussed. It has been found that for many types of incidents and scenarios, systems based on unshielded high-resolution detectors and hand-held instruments do have the required sensitivity to identify people who require medical assessment. JF - Journal of Radiological Protection AU - Youngman, M J AD - Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxon, OX11 0RQ, UK, mike.youngman@phe.gov.uk Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - R1 EP - R15 PB - IOP Publishing, The Public Ledger Building, Suite 929 Philadelphia PA 19106 United States VL - 35 IS - 2 SN - 0952-4746, 0952-4746 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - internal KW - contamination KW - emergencies KW - monitoring KW - screening KW - thyroid KW - whole body KW - Sensitivity KW - Monitoring methods KW - Radiation KW - Contamination KW - Reviews KW - Radioactive materials KW - Radioisotopes KW - Monitoring instruments KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732810544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Radiological+Protection&rft.atitle=Review+of+methods+to+measure+internal+contamination+in+an+emergency&rft.au=Youngman%2C+M+J&rft.aulast=Youngman&rft.aufirst=M&rft.date=2015-01-01&rft.volume=35&rft.issue=2&rft.spage=R1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Radiological+Protection&rft.issn=09524746&rft_id=info:doi/10.1088%2F0952-4746%2F35%2F2%2FR1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Sensitivity; Monitoring methods; Contamination; Radiation; Reviews; Radioactive materials; Radioisotopes; Monitoring instruments DO - http://dx.doi.org/10.1088/0952-4746/35/2/R1 ER - TY - JOUR T1 - Musculoskeletal disorders and associated healthcare costs among family members of injured workers AN - 1727696610; PQ0002166930 AB - Background Research has infrequently looked beyond the injured worker when gauging the burden of occupational injury. Objectives We explored the relationship between occupational injury and musculoskeletal disorders (MSDs) among family members of injured workers. Data and Methods We used 2005 and 2006 Truven Health Analytics databases, which contain information on workers' compensation and family healthcare claims. We used descriptive analyses, and negative binomial and two-part models. Results Family members of severely injured workers had a 15% increase in the total number of MSD outpatient claims and a 34% increase in the mean cost of MSD claims compared to family members of non-severely injured workers within 3 months after injury. Extrapolating cost results to the national level implies that severe occupational injury would be associated with between $29 and $33 million additional cost of family member outpatient MSD claims. Conclusion Occupational injury can impose a formerly unrecognized health burden on family members of injured workers. Am. J. Ind. Med. 58:1205-1216, 2015. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Asfaw, Abay AU - Pana-Cryan, Regina AU - Bushnell, Tim AU - Sauter, Steven AD - Centers for Disease Control and Prevention (CDC)-National Institute for Occupational Safety and Health (NIOSH), Economic Research and Support Office (ERSO), Washington, District of Columbia. PY - 2015 SP - 1205 EP - 1216 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 11 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Workers' compensation KW - USA KW - Musculoskeletal system KW - Health care KW - Injuries KW - Occupational safety KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727696610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Musculoskeletal+disorders+and+associated+healthcare+costs+among+family+members+of+injured+workers&rft.au=Asfaw%2C+Abay%3BPana-Cryan%2C+Regina%3BBushnell%2C+Tim%3BSauter%2C+Steven&rft.aulast=Asfaw&rft.aufirst=Abay&rft.date=2015-01-01&rft.volume=58&rft.issue=11&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22500 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Workers' compensation; Musculoskeletal system; Injuries; Health care; Occupational safety; Occupational health; USA DO - http://dx.doi.org/10.1002/ajim.22500 ER - TY - JOUR T1 - Styrene-associated health outcomes at a windblade manufacturing plant AN - 1727680917; PQ0002166935 AB - Background Health risks of using styrene to manufacture windblades for the green energy sector are unknown. Methods Using data collected from 355 (73%) current windblade workers and regression analysis, we investigated associations between health outcomes and styrene exposure estimates derived from urinary styrene metabolites. Results The median current styrene exposure was 53.6mg/g creatinine (interquartile range: 19.5-94.4). Color blindness in men and women (standardized morbidity ratios 2.3 and 16.6, respectively) was not associated with exposure estimates, but was the type previously reported with styrene. Visual contrast sensitivity decreased and chest tightness increased (odds ratio 2.9) with increasing current exposure. Decreases in spirometric parameters and FeNO, and increases in the odds of wheeze and asthma-like symptoms (odds ratios 1.3 and 1.2, respectively) occurred with increasing cumulative exposure. Conclusions Despite styrene exposures below the recommended 400mg/g creatinine, visual and respiratory effects indicate the need for additional preventative measures in this industry. Am. J. Ind. Med. 58:1150-1159, 2015. JF - American Journal of Industrial Medicine AU - McCague, Anna-Binney AU - Cox-Ganser, Jean M AU - Harney, Joshua M AU - Alwis, KUdeni AU - Blount, Benjamin C AU - Cummings, Kristin J AU - Edwards, Nicole AU - Kreiss, Kathleen AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. PY - 2015 SP - 1150 EP - 1159 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 11 SN - 0271-3586, 0271-3586 KW - Sustainability Science Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Styrene KW - Manufacturing industry KW - Health risks KW - Sensitivity KW - Currents KW - Urine KW - Green development KW - Standards KW - Metabolites KW - Morbidity KW - Occupational exposure KW - M3 1010:Issues in Sustainable Development KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727680917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Styrene-associated+health+outcomes+at+a+windblade+manufacturing+plant&rft.au=McCague%2C+Anna-Binney%3BCox-Ganser%2C+Jean+M%3BHarney%2C+Joshua+M%3BAlwis%2C+KUdeni%3BBlount%2C+Benjamin+C%3BCummings%2C+Kristin+J%3BEdwards%2C+Nicole%3BKreiss%2C+Kathleen&rft.aulast=McCague&rft.aufirst=Anna-Binney&rft.date=2015-01-01&rft.volume=58&rft.issue=11&rft.spage=1150&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22516 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Styrene; Sensitivity; Health risks; Manufacturing industry; Currents; Urine; Green development; Metabolites; Standards; Occupational exposure; Morbidity DO - http://dx.doi.org/10.1002/ajim.22516 ER - TY - JOUR T1 - Use of Dipeptidyl-Peptidase-4 Inhibitors and the Risk of Pneumonia: A Population-Based Cohort Study. AN - 1722931374; 26468883 AB - Dipeptidyl-peptidase-4 inhibitors (DPP4Is) are drugs for the treatment of type 2 diabetes mellitus (T2DM). There is increasing evidence that DPP4Is may result in suppression of the immune system and may increase the risk of infections such as pneumonia. Aim of this study was to evaluate the association between the use of DPP4Is and the risk of pneumonia in a population-based study. We conducted a population-based cohort study using data from the world's largest primary care database, the UK Clinical Practice Research Datalink (CPRD). We selected all users of non-insulin antidiabetic drugs (NIADs), including DPP4Is, between 2007 and 2012. To each NIAD user, we matched randomly selected non-users. The NIAD user's first prescription defined the index date, which was then assigned to the matched non-users. Patients were followed from their first prescription until end of data collection or the first event of pneumonia, whichever came first. Cox regression analysis estimated the association between pneumonia and current use of DPP4Is versus 1) current use of other NIADs and 2) non-users. DPP4I use was then stratified to daily and cumulative dose. Analyses were statistically adjusted for age, sex, lifestyle factors and comorbidities and concomitant use of various other drugs. Risk of pneumonia was not increased with current DPP4I use versus use of other NIADs, adjusted Hazard Ratio (HR) 0.70; 95% Confidence Interval (CI) 0.55-0.91. Also higher cumulative doses or daily doses did not further increase risk of pneumonia. We found no increased risk of pneumonia in T2DM patients using DPP4Is compared to T2DM patients using other NIADs. Our finding is in line with direct and indirect evidence from observational studies and RCTs. There is probably no need to avoid prescribing of DPP4Is to elderly patients who are at risk of pneumonia. JF - PloS one AU - Wvan der Zanden, Rogier AU - de Vries, Frank AU - Lalmohamed, Arief AU - Driessen, Johanna H M AU - de Boer, Anthonius AU - Rohde, Gernot AU - Neef, Cees AU - den Heijer, Casper AD - Department of Clinical Pharmacy and Toxicology, Maastricht University, Medical Centre+, Maastricht, Netherlands; Care and Public Health Research Institute (CAPHRI), Maastricht, Netherlands. ; Department of Clinical Pharmacy and Toxicology, Maastricht University, Medical Centre+, Maastricht, Netherlands; Care and Public Health Research Institute (CAPHRI), Maastricht, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands. ; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, Netherlands. ; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands. ; Department of Respiratory Medicine, Maastricht University, Medical Centre+, Maastricht, Netherlands. ; Department of Sexual Health, Infectious Diseases and Environmental Health, Public Health Service South Limburg, Geleen, Netherlands; Department of Microbiology, Maastricht University Medical Centre+, Maastricht, Netherlands. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 10 KW - Dipeptidyl-Peptidase IV Inhibitors KW - 0 KW - Index Medicus KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Young Adult KW - Risk KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Pneumonia -- chemically induced KW - Dipeptidyl-Peptidase IV Inhibitors -- adverse effects KW - Dipeptidyl-Peptidase IV Inhibitors -- therapeutic use KW - Pneumonia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722931374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Use+of+Dipeptidyl-Peptidase-4+Inhibitors+and+the+Risk+of+Pneumonia%3A+A+Population-Based+Cohort+Study.&rft.au=Wvan+der+Zanden%2C+Rogier%3Bde+Vries%2C+Frank%3BLalmohamed%2C+Arief%3BDriessen%2C+Johanna+H+M%3Bde+Boer%2C+Anthonius%3BRohde%2C+Gernot%3BNeef%2C+Cees%3Bden+Heijer%2C+Casper&rft.aulast=Wvan+der+Zanden&rft.aufirst=Rogier&rft.date=2015-01-01&rft.volume=10&rft.issue=10&rft.spage=e0139367&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0139367 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-20 N1 - Date created - 2015-10-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Ann N Y Acad Sci. 2007 Sep;1110:402-9 [17911455] Bone. 2014 Nov;68:124-30 [25093264] Diabetes Care. 2014 Aug;37(8):2218-24 [24842984] Eur J Clin Microbiol Infect Dis. 2014 Jul;33(7):1065-79 [24532008] Diabetes Obes Metab. 2012 Dec;14(12):1061-72 [22519906] Mol Cancer Res. 2013 Dec;11(12):1487-96 [24038034] J Clin Endocrinol Metab. 2013 Jun;98(6):2553-61 [23539735] Immunol Rev. 2013 Mar;252(1):156-63 [23405903] Curr Opin Immunol. 2012 Aug;24(4):424-30 [22841348] J Clin Pharm Ther. 2012 Aug;37(4):386-98 [22191695] BMJ. 2012;344:e1369 [22411919] Thorax. 2012 Jan;67(1):71-9 [20729232] Osteoporos Int. 2011 May;22(5):1641-2 [20563562] JAMA. 2007 Jul 11;298(2):194-206 [17622601] Clin Ther. 2006 Oct;28(10):1556-68 [17157112] Thorax. 2006 Nov;61(11):957-61 [16809409] Int J Epidemiol. 2006 Oct;35(5):1301-8 [17053011] Diabetes. 2005 Oct;54(10):2988-94 [16186403] Immunol Rev. 1998 Feb;161:55-70 [9553764] Immunol Rev. 1998 Feb;161:43-53 [9553763] Stat Med. 1991 Apr;10(4):577-81 [2057656] N Engl J Med. 2004 Jun 10;350(24):2487-98 [15190141] Adv Exp Med Biol. 2003;524:165-74 [12675236] Diabetes Obes Metab. 2015 Apr;17(4):379-85 [25581902] Diabetes Care. 2015 Mar;38(3):495-502 [25552419] Curr Med Res Opin. 2009 Oct;25(10):2401-11 [19650754] Cancer Immunol Immunother. 2009 Nov;58(11):1723-47 [19557413] Cochrane Database Syst Rev. 2008;(2):CD006739 [18425967] Br J Clin Pharmacol. 2010 Jan;69(1):4-14 [20078607] Diabetes Care. 2011 Feb;34(2):369-74 [21270195] J Diabetes Complications. 2010 May-Jun;24(3):209-13 [19854074] Br J Gen Pract. 2010 Mar;60(572):e128-36 [20202356] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0139367 ER - TY - JOUR T1 - Investigations into the Immunotoxicity and Allergic Potential Induced by Topical Application of N-Butylbenzenesulfonamide (NBBS) in a Murine Model. AN - 1722425598; 26291892 AB - N-Butylbenzene sulfonamide (NBBS) is a commonly used plasticizer found in numerous products. Due to its extensive use, lack of adequate toxicological data, and suspicion of toxicity based on the presence of structural alerts, it was nominated to the National Toxicology Program for comprehensive toxicological testing. The purpose of this study was to evaluate the potential for hypersensitivity and immune suppression following dermal exposure to NBBS using a murine model. NBBS tested negative in a combined irritancy/local lymph node assay (LLNA), classifying it as nonirritating and nonsensitizing. To estimate the immunosuppressive potential of NBBS, assays that assessed immunotoxicity were performed, including the immumnoglobulin (Ig) M response to T-cell-dependent antigen sheep red blood cells (SRBC), using the plaque-forming cell (PFC) assay and immune cell phenotyping. After a 28-d treatment with NBBS, mice exposed to the lowest concentration (25% NBBS) showed a significant increase in IgM-producing B cells in the spleen. No marked changes were identified in immune cell markers in the lymph node. In contrast to body weight, a significant elevation in kidney and liver weight was observed following dermal exposure to all concentrations of NBBS. These results demonstrate that dermal exposure to NBBS, other than liver and kidney toxicity, did not apparently induce immunotoxicity in a murine model. JF - Journal of toxicology and environmental health. Part A AU - Marrocco, Antonella AU - Meade, B Jean AU - Long, Carrie M AU - Lukomska, Ewa AU - Marshall, Nikki B AU - Anderson, Stacey E AD - a National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1122 EP - 1132 VL - 78 IS - 17 SN - 1528-7394, 1528-7394 KW - Immunoglobulin G KW - 0 KW - Immunosuppressive Agents KW - Plasticizers KW - Sulfonamides KW - N-butylbenzenesulfonamide KW - 3622-84-2 KW - Index Medicus KW - Animals KW - Administration, Cutaneous KW - Sheep KW - Mice KW - Immunoglobulin G -- immunology KW - Mice, Inbred BALB C KW - Immunosuppressive Agents -- pharmacology KW - Toxicity Tests KW - Spleen -- immunology KW - T-Lymphocytes -- drug effects KW - Spleen -- drug effects KW - T-Lymphocytes -- immunology KW - Female KW - Lymph Nodes -- immunology KW - Sulfonamides -- toxicity KW - Plasticizers -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722425598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Investigations+into+the+Immunotoxicity+and+Allergic+Potential+Induced+by+Topical+Application+of+N-Butylbenzenesulfonamide+%28NBBS%29+in+a+Murine+Model.&rft.au=Marrocco%2C+Antonella%3BMeade%2C+B+Jean%3BLong%2C+Carrie+M%3BLukomska%2C+Ewa%3BMarshall%2C+Nikki+B%3BAnderson%2C+Stacey+E&rft.aulast=Marrocco&rft.aufirst=Antonella&rft.date=2015-01-01&rft.volume=78&rft.issue=17&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2015.1056898 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-13 N1 - Date created - 2015-10-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Antibiot (Tokyo). 2000 Feb;53(2):131-6 [10805572] Toxicology. 2000 May 5;146(2-3):221-7 [10814854] Occup Environ Med. 2003 Feb;60(2):97-103 [12554836] Toxicol Sci. 2003 Sep;75(1):89-98 [12832659] Mar Pollut Bull. 2003 Sep;46(9):1102-10 [12932491] Environ Toxicol Chem. 2004 Sep;23(9):2074-83 [15378981] Fundam Appl Toxicol. 1988 Jan;10(1):2-19 [3280374] Acta Neuropathol. 1991;81(3):235-41 [2058361] Toxicol Lett. 1992 Dec;64-65 Spec No:71-8 [1471226] Ann N Y Acad Sci. 1993 May 28;679:280-7 [8512189] Food Chem Toxicol. 1998 Sep-Oct;36(9-10):831-9 [9737431] Fed Regist. 1999 Mar 23;64(55):14006-7 [10558409] Science. 1963 Apr 26;140(3565):405 [13957684] Food Addit Contam. 2005 Oct;22(10):1012-22 [16227185] Water Res. 2005 Nov;39(19):4735-48 [16280149] Hum Exp Toxicol. 2006 Jul;25(7):387-94 [16898167] Water Environ Res. 2007 Feb;79(2):156-67 [17370841] Toxicol Sci. 2007 Jun;97(2):253-64 [17369196] Pediatr Dermatol. 2008 Jan-Feb;25(1):1-6 [18304144] Dermatol Clin. 2012 Jan;30(1):87-98, viii [22117870] J Immunotoxicol. 2013 Jan-Mar;10(1):59-66 [22953780] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15287394.2015.1056898 ER - TY - JOUR T1 - Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model AN - 1722175855; PQ0002055775 AB - The printer is one of the most common office equipment. Recently, it was reported that toner formulations for printing equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during printing. To date, insufficient research has been performed to understand the potential toxicological properties of printer-emitted particles (PEPs) with several studies using bulk toner particles as test particles. These studies demonstrated the ability of toner particles to cause chronic inflammation and fibrosis in animal models. However, the toxicological implications of inhalation exposures to ENMs emitted from laser printing equipment remain largely unknown The present study investigates the toxicological effects of PEPs using an in vitro alveolar-capillary co-culture model with Human Small Airway Epithelial Cells (SAEC) and Human Microvascular Endothelial Cells (HMVEC). Our data demonstrate that direct exposure of SAEC to low concentrations of PEPs (0.5 and 1.0 mu g/mL) caused morphological changes of actin remodeling and gap formations within the endothelial monolayer. Furthermore, increased production of reactive oxygen species (ROS) and angiogenesis were observed in the HMVEC. Analysis of cytokine and chemokine levels demonstrates that interleukin (IL)-6 and MCP-1 may play a major role in the cellular communication observed between SAEC and HMVEC and the resultant responses in HMVEC. These data indicate that PEPs at low, non-cytotoxic exposure levels are bioactive and affect cellular responses in an alveolar-capillary co-culture model, which raises concerns for potential adverse health effects. JF - Nanotoxicology AU - Sisler, Jennifer D AU - Pirela, Sandra V AU - Friend, Sherri AU - Farcas, Mariana AU - Schwegler-Berry, Diane AU - Shvedova, Anna AU - Castranova, Vincent AU - Demokritou, Philip AU - Qian, Yong AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 769 EP - 779 PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA VL - 9 IS - 6 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Inhalation KW - Microvasculature KW - Epithelial cells KW - Chemokines KW - Data processing KW - Printing KW - Monocyte chemoattractant protein 1 KW - Interleukins KW - Angiogenesis KW - Animal models KW - Inflammation KW - Endothelial cells KW - Reactive oxygen species KW - Actin KW - Lasers KW - Cell interactions KW - nanoparticles KW - nanotechnology KW - Respiratory tract KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722175855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Small+airway+epithelial+cells+exposure+to+printer-emitted+engineered+nanoparticles+induces+cellular+effects+on+human+microvascular+endothelial+cells+in+an+alveolar-capillary+co-culture+model&rft.au=Sisler%2C+Jennifer+D%3BPirela%2C+Sandra+V%3BFriend%2C+Sherri%3BFarcas%2C+Mariana%3BSchwegler-Berry%2C+Diane%3BShvedova%2C+Anna%3BCastranova%2C+Vincent%3BDemokritou%2C+Philip%3BQian%2C+Yong&rft.aulast=Sisler&rft.aufirst=Jennifer&rft.date=2015-01-01&rft.volume=9&rft.issue=6&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2014.976603 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Inhalation; Epithelial cells; Microvasculature; Chemokines; Monocyte chemoattractant protein 1; Printing; Data processing; Animal models; Angiogenesis; Interleukins; Inflammation; Endothelial cells; Reactive oxygen species; Lasers; Actin; Cell interactions; nanoparticles; Respiratory tract; nanotechnology DO - http://dx.doi.org/10.3109/17435390.2014.976603 ER - TY - JOUR T1 - Epidemiological Scenario of Dengue in Brazil AN - 1722170464; PQ0002028848 AB - Dengue is the most important reemerging mosquito-borne viral disease worldwide. It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. JF - BioMed Research International AU - Fares, Rafaelle CG AU - Souza, Katia PR AU - Anez, German AU - Rios, Maria AD - United States Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD 20993, USA, maria.rios@fda.hhs.gov Y1 - 2015/01// PY - 2015 DA - January 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Dengue virus KW - Aedes KW - Human diseases KW - Geographical distribution KW - Serotypes KW - Vectors KW - Hosts KW - Genotypes KW - Infection KW - Public health KW - Disease transmission KW - pandemics KW - Viral diseases KW - Dengue KW - I, Pacific KW - ASW, Brazil KW - Aquatic insects KW - V 22410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05360:Genetics and Evolution KW - Q5 08524:Public health, medicines, dangerous organisms KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722170464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Epidemiological+Scenario+of+Dengue+in+Brazil&rft.au=Fares%2C+Rafaelle+CG%3BSouza%2C+Katia+PR%3BAnez%2C+German%3BRios%2C+Maria&rft.aulast=Fares&rft.aufirst=Rafaelle&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F321873 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 3 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Geographical distribution; Human diseases; Viral diseases; Genotypes; Hosts; Aquatic insects; Disease transmission; Public health; pandemics; Serotypes; Dengue; Vectors; Infection; Dengue virus; Aedes; I, Pacific; ASW, Brazil DO - http://dx.doi.org/10.1155/2015/321873 ER - TY - JOUR T1 - Perspectives of Fijian Policymakers on the Obesity Prevention Policy Landscape AN - 1722168427; PQ0002026601 AB - In Fiji and other Pacific Island countries, obesity has rapidly increased in the past decade. Therefore, several obesity prevention policies have been developed. Studies show that their development has been hampered by factors within Fiji's policy landscape such as pressure from industry. Since policymakers in the Fijian national government are primarily responsible for the development of obesity policies, it is important to understand their perspectives; we therefore interviewed 15 policymakers from nine Fijian ministries. By applying the "attractor landscape" metaphor from dynamic systems theory, we captured perceived barriers and facilitators in the policy landscape. A poor economic situation, low food self-sufficiency, power inequalities, inappropriate framing of obesity, limited policy evidence, and limited resource sharing hamper obesity policy developments in Fiji. Facilitators include policy entrepreneurs and policy brokers who were active when a window of opportunity opened and who strengthened intersectoral collaboration. Fiji's policy landscape can become more conducive to obesity policies if power inequalities are reduced. In Fiji and other Pacific Island countries, this may be achievable through increased food self-sufficiency, strengthened intersectoral collaboration, and the establishment of an explicit functional focal unit within government to monitor and forecast the health impact of policy changes in non-health sectors. JF - BioMed Research International AU - Hendriks, Anna-Marie AU - Delai, Mere Y AU - Thow, Anne-Marie AU - Gubbels, Jessica S AU - De Vries, Nanne K AU - Kremers, Stef PJ AU - Jansen, Maria WJ AD - Academic Collaborative Centre for Public Health Limburg, Regional Public Health Service, P.O. Box 2022, 6160 HA Geleen, Netherlands, anna-marie.hendriks@maastrichtuniversity.nl Y1 - 2015/01// PY - 2015 DA - January 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Biotechnology and Bioengineering Abstracts KW - Obesity KW - Islands KW - Food KW - Landscape KW - Economics KW - Development KW - Pressure KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722168427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Perspectives+of+Fijian+Policymakers+on+the+Obesity+Prevention+Policy+Landscape&rft.au=Hendriks%2C+Anna-Marie%3BDelai%2C+Mere+Y%3BThow%2C+Anne-Marie%3BGubbels%2C+Jessica+S%3BDe+Vries%2C+Nanne+K%3BKremers%2C+Stef+PJ%3BJansen%2C+Maria+WJ&rft.aulast=Hendriks&rft.aufirst=Anna-Marie&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F926159 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 1 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Obesity; Islands; Food; Economics; Landscape; Development; Pressure DO - http://dx.doi.org/10.1155/2015/926159 ER - TY - JOUR T1 - Construction of a gE-Deleted Pseudorabies Virus and Its Efficacy to the New-Emerging Variant PRV Challenge in the Form of Killed Vaccine AN - 1722168088; PQ0002030505 AB - The new-emerging PRV variants plague the vaccinated pigs and caused huge economic loss to local pig industry in China since 2011. The current commercial PRV vaccines cannot provide complete protection as the new-emerging PRV variants are antigenically different from the classical viruses. It is urgent to develop more safe and effective PRV vaccines based on the current circulating field isolates. In this study, a gE gene-deleted PRV based on the PRV HN1201, a representative PRV variant, was generated and the efficacy was tested on 3-week-old pigs in the form of killed vaccine. After fatal PRV HN1201 challenge, all vaccinated pigs survived without showing any clinical symptoms, but all unvaccinated pigs exhibited pseudorabies-specific respiratory and neurological signs with 100% mortality rate within 6 days after infection. The vaccinated pigs developed high level of gB and neutralizing antibodies after vaccination which may correlate to the protection provided by vaccine. Therefore, this gE gene-deleted PRV could be a promising vaccine candidate for the control of currently epidemic pseudorabies in China. JF - BioMed Research International AU - Wang, Tongyan AU - Xiao, Yan AU - Yang, Qingyuan AU - Wang, Yuzhou AU - Sun, Zhe AU - Zhang, Chaoling AU - Yan, Shijun AU - Wang, Juan AU - Guo, Linghua AU - Yan, He AU - Gao, Zhiyu AU - Wang, Lilin AU - Li, Xiangdong AU - Tan, Feifei AU - Tian, Kegong AD - National Research Center for Veterinary Medicine, Road Cuiwei, High-Tech District, Luoyang 471003, China, tf0801@126.com Y1 - 2015/01// PY - 2015 DA - January 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Pseudorabies virus KW - Pseudorabies KW - Mortality KW - Antibodies KW - Epidemics KW - Economics KW - Vaccines KW - Plague KW - Infection KW - V 22410:Animal Diseases KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722168088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Construction+of+a+gE-Deleted+Pseudorabies+Virus+and+Its+Efficacy+to+the+New-Emerging+Variant+PRV+Challenge+in+the+Form+of+Killed+Vaccine&rft.au=Wang%2C+Tongyan%3BXiao%2C+Yan%3BYang%2C+Qingyuan%3BWang%2C+Yuzhou%3BSun%2C+Zhe%3BZhang%2C+Chaoling%3BYan%2C+Shijun%3BWang%2C+Juan%3BGuo%2C+Linghua%3BYan%2C+He%3BGao%2C+Zhiyu%3BWang%2C+Lilin%3BLi%2C+Xiangdong%3BTan%2C+Feifei%3BTian%2C+Kegong&rft.aulast=Wang&rft.aufirst=Tongyan&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F684945 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Pseudorabies; Mortality; Antibodies; Epidemics; Economics; Plague; Vaccines; Infection; Pseudorabies virus DO - http://dx.doi.org/10.1155/2015/684945 ER - TY - JOUR T1 - Advances in mechanisms and signaling pathways of carbon nanotube toxicity AN - 1722165707; PQ0002058458 AB - Carbon nanotubes (CNT) have been developed into new materials with a variety of industrial and commercial applications. In contrast, the physicochemical properties of CNT at the nanoscale render them the potency to generate toxic effects. Indeed, the potential health impacts of CNT have drawn a great deal of attention in recent years, owing to their identified toxicological and pathological consequences including cytotoxicity, inflammation, fibrosis, genotoxicity, tumorigenesis, and immunotoxicity. Understanding the mechanisms by which CNT induce toxicity and pathology is thus urgently needed for accurate risk assessment of CNT exposure in humans, and for safe and responsible development and commercialization of nanotechnology. Here, we summarize and discuss recent advances in this area with a focus on the molecular interactions between CNT and mammalian systems, and the signaling pathways important for the development of CNT toxicity such as the NF- Kappa B, NLRP3 inflammasome, TGF- beta 1, MAPK, and p53 signaling cascades. With the current mechanistic evidence summarized in this review, we expect to provide new insights into CNT toxicology at the molecular level and offer new clues to the prevention of health effects resulting from CNT exposure. Moreover, we disclose questions and issues that remain in this rapidly advancing field of nanotoxicology, which would facilitate ascertaining future research directions. JF - Nanotoxicology AU - Dong, Jie AU - Ma, Oiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 658 EP - 676 PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA VL - 9 IS - 5 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Risk assessment KW - Transforming growth factor- beta 1 KW - MAP kinase KW - Fibrosis KW - Tumorigenesis KW - Physicochemical properties KW - Genotoxicity KW - NF- Kappa B protein KW - Inflammation KW - p53 protein KW - Immunotoxicity KW - Cytotoxicity KW - Carbon KW - Reviews KW - nanotechnology KW - Signal transduction KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722165707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Advances+in+mechanisms+and+signaling+pathways+of+carbon+nanotube+toxicity&rft.au=Dong%2C+Jie%3BMa%2C+Oiang&rft.aulast=Dong&rft.aufirst=Jie&rft.date=2015-01-01&rft.volume=9&rft.issue=5&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2015.1009187 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Transforming growth factor- beta 1; Risk assessment; MAP kinase; Fibrosis; Genotoxicity; Physicochemical properties; Tumorigenesis; p53 protein; Inflammation; NF- Kappa B protein; Cytotoxicity; Immunotoxicity; Carbon; Reviews; Signal transduction; nanotechnology DO - http://dx.doi.org/10.3109/17435390.2015.1009187 ER - TY - JOUR T1 - Risk Factors for Leprosy Reactions in Three Endemic Countries AN - 1722164397; PQ0002059451 AB - The objective of this study was to ascertain risk factors for complications (reactions or neuritis) in leprosy patients at the time of diagnosis in three leprosy-endemic countries. Newly diagnosed patients were enrolled in Brazil, the Philippines, and Nepal, and risk factors for reactions and neuritis were assessed using a case-control approach: "cases" were patients with these complications, and controls were patients without complications. Of 1,972 patients enrolled in this study, 22% had complications before treatment. Type 1 reaction was diagnosed in 1 3.7% of patients, neuritis alone in 6.9.%, and type 2 reaction in 1.4%. The frequency of these complications was higher in Nepal, in lepromatous patients, in males, and in adults versus children. Reactions and neuritis were seen in patients at diagnosis, before treatment was started. Reactions were seen in adults and children, even in patients with only a single lesion. Neuritis was often present without other signs of reaction. Reactions and neuritis were more likely to occur in lepromatous patients, and were more likely to be seen in adults than in children. JF - American Journal of Tropical Medicine and Hygiene AU - Scollard, David M AU - Martelli, Celina M T AU - Stefani, Mariane M A AU - Maroja, Maria de Fatima AU - Villahermosa, Laarni AU - Pardillo, Fe AU - Tamang, Krishna B AD - National Flansen's Disease Programs, Baton Rouge, Louisiana, dscollard@hrsa.gov Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 108 EP - 114 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 92 IS - 1 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Endemic species KW - ISEW, Philippines KW - Risk factors KW - ASW, Brazil KW - Children KW - Hygiene KW - Nepal KW - Risks KW - Neuritis KW - Leprosy KW - K 03400:Human Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08505:Prevention and control KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722164397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Risk+Factors+for+Leprosy+Reactions+in+Three+Endemic+Countries&rft.au=Scollard%2C+David+M%3BMartelli%2C+Celina+M+T%3BStefani%2C+Mariane+M+A%3BMaroja%2C+Maria+de+Fatima%3BVillahermosa%2C+Laarni%3BPardillo%2C+Fe%3BTamang%2C+Krishna+B&rft.aulast=Scollard&rft.aufirst=David&rft.date=2015-01-01&rft.volume=92&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.13-0221 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Endemic species; Hygiene; Risks; Risk factors; Children; Leprosy; Neuritis; ISEW, Philippines; ASW, Brazil; Nepal DO - http://dx.doi.org/10.4269/ajtmh.13-0221 ER - TY - JOUR T1 - Detecting Lung Diseases from Exhaled Aerosols: Non-Invasive Lung Diagnosis Using Fractal Analysis and SVM Classification. AN - 1718910407; 26422016 AB - Each lung structure exhales a unique pattern of aerosols, which can be used to detect and monitor lung diseases non-invasively. The challenges are accurately interpreting the exhaled aerosol fingerprints and quantitatively correlating them to the lung diseases. In this study, we presented a paradigm of an exhaled aerosol test that addresses the above two challenges and is promising to detect the site and severity of lung diseases. This paradigm consists of two steps: image feature extraction using sub-regional fractal analysis and data classification using a support vector machine (SVM). Numerical experiments were conducted to evaluate the feasibility of the breath test in four asthmatic lung models. A high-fidelity image-CFD approach was employed to compute the exhaled aerosol patterns under different disease conditions. By employing the 10-fold cross-validation method, we achieved 100% classification accuracy among four asthmatic models using an ideal 108-sample dataset and 99.1% accuracy using a more realistic 324-sample dataset. The fractal-SVM classifier has been shown to be robust, highly sensitive to structural variations, and inherently suitable for investigating aerosol-disease correlations. For the first time, this study quantitatively linked the exhaled aerosol patterns with their underlying diseases and set the stage for the development of a computer-aided diagnostic system for non-invasive detection of obstructive respiratory diseases. JF - PloS one AU - Xi, Jinxiang AU - Zhao, Weizhong AU - Yuan, Jiayao Eddie AU - Kim, JongWon AU - Si, Xiuhua AU - Xu, Xiaowei AD - School of Engineering and Technology, Central Michigan University, Mount Pleasant, Michigan, United States of America. ; College of Information Engineering, Xiangtan University, Xiangtan, Hunan Province, China; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, Arkansas, United States of America. ; College of Engineering, University of Georgia, Athens, Georgia, United States of America. ; Department of Mechanical Engineering, California Baptist University, Riverside, California, United States of America. ; Department of Information Science, University of Arkansas, Little Rock, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 9 KW - Aerosols KW - 0 KW - Index Medicus KW - Humans KW - Prognosis KW - Breath Tests KW - Aerosols -- classification KW - Lung Diseases -- diagnosis KW - Support Vector Machine KW - Asthma -- diagnosis KW - Aerosols -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718910407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Detecting+Lung+Diseases+from+Exhaled+Aerosols%3A+Non-Invasive+Lung+Diagnosis+Using+Fractal+Analysis+and+SVM+Classification.&rft.au=Xi%2C+Jinxiang%3BZhao%2C+Weizhong%3BYuan%2C+Jiayao+Eddie%3BKim%2C+JongWon%3BSi%2C+Xiuhua%3BXu%2C+Xiaowei&rft.aulast=Xi&rft.aufirst=Jinxiang&rft.date=2015-01-01&rft.volume=10&rft.issue=9&rft.spage=e0139511&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0139511 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-19 N1 - Date created - 2015-10-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Biol Res. 2000;33(1):31-5 [11021308] Am J Respir Crit Care Med. 2001 Sep 1;164(5):731-7 [11549524] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15149-54 [11742071] Biosens Bioelectron. 2003 Sep;18(10):1209-18 [12835038] Chest. 2003 Oct;124(4):1373-80 [14555568] Nature. 2004 Feb 12;427(6975):633-6 [14961120] Clin Chim Acta. 2004 Sep;347(1-2):25-39 [15313139] Nature. 1967 Feb 18;213(5077):668-9 [6031769] J Appl Physiol (1985). 1990 Feb;68(2):457-61 [2318756] J Aerosol Med. 1994;7(1):77-88 [10147059] J Aerosol Med. 1996 Summer;9(2):183-205 [10163350] J Pathol. 1998 Aug;185(4):366-81 [9828835] Science. 1962 Aug 24;137(3530):577-85 [14005590] Am J Respir Crit Care Med. 2005 Oct 1;172(7):817-23 [15976372] Nat Biotechnol. 2006 Dec;24(12):1565-7 [17160063] Ann Biomed Eng. 2007 Apr;35(4):560-81 [17237991] IEEE Trans Med Imaging. 2007 Oct;26(10):1366-78 [17948727] Clin Exp Allergy. 2008 Apr;38(4):557-65 [18352973] J Appl Physiol (1985). 2008 Jun;104(6):1761-77 [18388247] Ann Biomed Eng. 2008 Oct;36(10):1714-34 [18712605] Lung Cancer. 2009 Feb;63(2):164-8 [18599152] J Thorac Oncol. 2009 Feb;4(2):172-8 [19179892] Curr Drug Targets. 2011 Apr;12(4):469-77 [21194408] Int J Numer Method Biomed Eng. 2013 Jan;29(1):17-39 [23293067] Respir Physiol Neurobiol. 2013 Mar 1;186(1):22-32 [23313127] Inhal Toxicol. 2014 Jul;26(8):492-505 [24987981] PLoS One. 2014;9(8):e104682 [25105680] Theranostics. 2015;5(5):443-55 [25767612] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0139511 ER - TY - JOUR T1 - Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. AN - 1699492865; 26208104 AB - Metabolomics approaches have enabled the study of new mechanisms of liver injury in experimental models of drug toxicity. Disruption of bile acid homeostasis is a known mechanism of drug induced liver injury. The relationship of individual bile acids to indicators of oxidative drug metabolism (acetaminophen protein adducts) and liver injury was examined in children with acetaminophen overdose, hospitalized children with low dose exposure to acetaminophen, and children with no recent exposure to acetaminophen. Nine bile acids were quantified through targeted metabolomic analysis in the serum samples of the three groups. Bile acids were compared to serum levels of acetaminophen protein adducts and alanine aminotransferase. Glycodeoxycholic acid, taurodeoxycholic acid, and glycochenodeoxycholic acid were significantly increased in children with acetaminophen overdose compared to healthy controls. Among patients with acetaminophen overdose, bile acids were higher in subjects with acetaminophen protein adduct values > 1.0 nmol/mL and modest correlations were noted for three bile acids and acetaminophen protein adducts as follows: taurodeoxycholic acid (R=0.604; p<0.001), glycodeoxycholic acid (R=0.581; p<0.001), and glycochenodeoxycholic acid (R=0.571; p<0.001). Variability in bile acids was greater among hospitalized children receiving low doses of acetaminophen than in healthy children with no recent acetaminophen exposure. Compared to bile acids, acetaminophen protein adducts more accurately discriminated among children with acetaminophen overdose, children with low dose exposure to acetaminophen, and healthy control subjects. In children with acetaminophen overdose, elevations of conjugated bile acids were associated with specific indicators of acetaminophen metabolism and non-specific indicators of liver injury. JF - PloS one AU - James, Laura AU - Yan, Ke AU - Pence, Lisa AU - Simpson, Pippa AU - Bhattacharyya, Sudeepa AU - Gill, Pritmohinder AU - Letzig, Lynda AU - Kearns, Gregory AU - Beger, Richard AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, United States of America; Arkansas Children's Hospital Research Institute, Little Rock, AR 72202, United States of America. ; Medical College of Wisconsin, Milwaukee, WI 53226, United States of America. ; Division of Systems Biology, National Center for Toxicological Research, Jefferson, AR 72079, United States of America. ; Division of Pediatric Pharmacology, Medical Toxicology and Therapeutic Innovation, The Children's Mercy Hospital, Kansas City, MO 64108, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 7 KW - Bile Acids and Salts KW - 0 KW - Biomarkers KW - Glycodeoxycholic Acid KW - 360-65-6 KW - Acetaminophen KW - 362O9ITL9D KW - Taurodeoxycholic Acid KW - 516-50-7 KW - Glycochenodeoxycholic Acid KW - 640-79-9 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Sensitivity and Specificity KW - Taurodeoxycholic Acid -- blood KW - Metabolomics -- methods KW - Diagnosis, Differential KW - Alanine Transaminase -- metabolism KW - Humans KW - Glycochenodeoxycholic Acid -- blood KW - Child KW - Glycodeoxycholic Acid -- blood KW - Homeostasis KW - Protein Binding KW - Child, Preschool KW - Adolescent KW - Biomarkers -- blood KW - Female KW - Male KW - Chemical and Drug Induced Liver Injury -- blood KW - Bile Acids and Salts -- blood KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Acetaminophen -- poisoning KW - Acetaminophen -- metabolism KW - Drug Overdose -- diagnosis KW - Drug Overdose -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1699492865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Comparison+of+Bile+Acids+and+Acetaminophen+Protein+Adducts+in+Children+and+Adolescents+with+Acetaminophen+Toxicity.&rft.au=James%2C+Laura%3BYan%2C+Ke%3BPence%2C+Lisa%3BSimpson%2C+Pippa%3BBhattacharyya%2C+Sudeepa%3BGill%2C+Pritmohinder%3BLetzig%2C+Lynda%3BKearns%2C+Gregory%3BBeger%2C+Richard&rft.aulast=James&rft.aufirst=Laura&rft.date=2015-01-01&rft.volume=10&rft.issue=7&rft.spage=e0131010&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0131010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-02 N1 - Date created - 2015-07-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Arch Surg. 1996 Dec;131(12):1280-7; discussion 1287-8 [8956769] Toxicol Sci. 2014 Jan;137(1):12-25 [24085190] Arch Pediatr Adolesc Med. 2000 Apr;154(4):346-50 [10768670] Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1274-9 [11352821] Drug Metab Dispos. 2002 Apr;30(4):446-51 [11901099] Gut. 2002 Jul;51(1):113-9 [12077103] Toxicol Sci. 2003 Nov;76(1):220-8 [12944587] Drug Metab Dispos. 2003 Dec;31(12):1499-506 [14625346] Hepatology. 2004 Nov;40(5):1170-9 [15486922] J Pharmacol Exp Ther. 1973 Oct;187(1):185-94 [4746326] Pediatrics. 1975 Jun;55(6):871-6 [1134886] Lancet. 1975 Sep 27;2(7935):579-81 [51407] Pediatr Clin North Am. 1986 Jun;33(3):691-701 [3714342] N Engl J Med. 1988 Dec 15;319(24):1557-62 [3059186] Biochem Pharmacol. 1990 Aug 1;40(3):573-9 [2200409] Am J Pathol. 1991 Feb;138(2):359-71 [1992763] Hepatology. 1998 Mar;27(3):748-54 [9500703] Hepatology. 2005 Dec;42(6):1364-72 [16317692] Gastroenterology. 2006 Mar;130(3):687-94 [16530510] Nature. 2006 Apr 20;440(7087):1073-7 [16625200] Pharmacogenomics. 2006 Oct;7(7):1077-86 [17054417] Toxicol Appl Pharmacol. 2008 Jan 1;226(1):74-83 [17935745] J Biol Chem. 2008 May 16;283(20):13565-77 [18337250] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 15;871(2):328-40 [18472313] Clin Pharmacol Ther. 2008 Dec;84(6):684-90 [18923390] Chem Res Toxicol. 2009 Apr;22(4):699-707 [19256530] Toxicol Sci. 2014 Dec;142(2):436-44 [25239633] Drug Metab Dispos. 2009 Aug;37(8):1779-84 [19439490] Ann Emerg Med. 2009 Sep;54(3):421-3 [18986731] Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14728-33 [19667173] Toxicology. 2010 Feb 28;269(1):24-34 [20067817] Hepatology. 2011 Feb;53(2):567-76 [21274877] Toxicol Appl Pharmacol. 2011 May 1;252(3):211-20 [21316383] Electrophoresis. 2011 Aug;32(15):2063-70 [21732555] Toxicol Appl Pharmacol. 2013 Apr 1;268(1):79-89 [23360887] Toxicol Appl Pharmacol. 2013 Apr 15;268(2):132-40 [23391614] Eur J Clin Pharmacol. 2013 Apr;69(4):851-7 [23052410] Compr Physiol. 2013 Jul;3(3):1191-212 [23897684] Am J Pathol. 2013 Nov;183(5):1518-26 [24007882] Biomark Med. 2014;8(2):147-59 [24521011] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0131010 ER - TY - JOUR T1 - Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood. AN - 1697755641; 26177368 AB - Methods were developed to evaluate the stability of rat whole blood expression obtained from RNA sequencing (RNA-seq) and assess changes in whole blood transcriptome profiles in experiments replicated over time. Expression was measured in globin-depleted RNA extracted from the whole blood of Sprague-Dawley rats, given either saline (control) or neurotoxic doses of amphetamine (AMPH). The experiment was repeated four times (paired control and AMPH groups) over a 2-year span. The transcriptome of the control and AMPH-treated groups was evaluated on: 1) transcript levels for ribosomal protein subunits; 2) relative expression of immune-related genes; 3) stability of the control transcriptome over 2 years; and 4) stability of the effects of AMPH on immune-related genes over 2 years. All, except one, of the 70 genes that encode the 80s ribosome had levels that ranked in the top 5% of all mean expression levels. Deviations in sequencing performance led to significant changes in the ribosomal transcripts. The overall expression profile of immune-related genes and genes specific to monocytes, T-cells or B-cells were well represented and consistent within treatment groups. There were no differences between the levels of ribosomal transcripts in time-matched control and AMPH groups but significant differences in the expression of immune-related genes between control and AMPH groups. AMPH significantly increased expression of some genes related to monocytes but down-regulated those specific to T-cells. These changes were partially due to changes in the two types of leukocytes present in blood, which indicate an activation of the innate immune system by AMPH. Thus, the stability of RNA-seq whole blood transcriptome can be verified by assessing ribosomal protein subunits and immune-related gene expression. Such stability enables the pooling of samples from replicate experiments to carry out differential expression analysis with acceptable power. JF - PloS one AU - Bowyer, John F AU - Tranter, Karen M AU - Hanig, Joseph P AU - Crabtree, Nathaniel M AU - Schleimer, Robert P AU - George, Nysia I AD - Division of Neurotoxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America. ; Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, United States of America. ; Division of Allergy and Immunology, Northwestern Feinberg School of Medicine, Chicago, Illinois, United States of America. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 7 KW - RNA, Messenger KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Ribosome Subunits -- genetics KW - Leukocytes -- metabolism KW - Animals KW - Rats, Sprague-Dawley KW - RNA, Messenger -- metabolism KW - Ribosome Subunits -- metabolism KW - Gene Expression Regulation -- drug effects KW - RNA, Messenger -- genetics KW - Male KW - Leukocytes -- drug effects KW - Gene Expression Profiling KW - Transcriptome -- genetics KW - RNA Stability -- drug effects KW - Sequence Analysis, RNA KW - RNA Stability -- genetics KW - Blood -- metabolism KW - Blood -- drug effects KW - Immunity -- drug effects KW - Amphetamine -- pharmacology KW - Transcriptome -- drug effects KW - Immunity -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697755641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Evaluating+the+Stability+of+RNA-Seq+Transcriptome+Profiles+and+Drug-Induced+Immune-Related+Expression+Changes+in+Whole+Blood.&rft.au=Bowyer%2C+John+F%3BTranter%2C+Karen+M%3BHanig%2C+Joseph+P%3BCrabtree%2C+Nathaniel+M%3BSchleimer%2C+Robert+P%3BGeorge%2C+Nysia+I&rft.aulast=Bowyer&rft.aufirst=John&rft.date=2015-01-01&rft.volume=10&rft.issue=7&rft.spage=e0133315&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0133315 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-03 N1 - Date created - 2015-07-16 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - GSE62368; GEO; GSE64778 N1 - SuppNotes - Cited By: Cell Immunol. 2014 Sep-Oct;291(1-2):32-40 [25205002] BMC Genomics. 2013;14:147 [23497014] BMC Med Genomics. 2013;6:26 [23883607] Diabetes Obes Metab. 2013 Sep;15 Suppl 3:10-8 [24003916] Int J Oncol. 2013 Nov;43(5):1343-50 [23969601] Psychiatry Res. 2013 Nov 30;210(1):287-93 [23778302] PLoS One. 2015;10(6):e0125224 [26039068] Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15448-53 [17873064] Annu Rev Immunol. 2001;19:197-223 [11244035] Blood. 2001 Apr 15;97(8):2457-68 [11290611] Immunity. 2001 Jun;14(6):779-90 [11420047] Immunol Rev. 2001 Jun;181:234-49 [11513145] Genome Biol. 2002 Jun 18;3(7):RESEARCH0034 [12184808] Neurotoxicology. 2002 Sep;23(3):397-414 [12387366] Nat Rev Immunol. 2002 Dec;2(12):909-19 [12461564] Immunity. 2003 Jul;19(1):71-82 [12871640] Immunol Rev. 1987 Dec;100:225-60 [3326822] FASEB J. 1988 Jul;2(10):2584-90 [2838364] Science. 1989 Jan 20;243(4889):398-400 [2563176] Immunol Rev. 1989 Oct;111:145-75 [2697680] J Immunol. 1995 Apr 1;154(7):3333-40 [7897216] FASEB J. 1995 Jul;9(10):866-73 [7542213] Science. 1995 Sep 15;269(5230):1583-5 [7667639] Genes Immun. 2005 Jun;6(4):279-84 [15815687] Mol Diagn Ther. 2006;10(4):257-69 [16884330] Biotechniques. 2007 Apr;42(4):503-12 [17489238] Biochem J. 2000 Mar 15;346 Pt 3:729-36 [10698700] Brain Behav Immun. 2007 Aug;21(6):736-45 [17467231] Trends Mol Med. 2007 Oct;13(10):422-32 [17919976] Genome Res. 2008 Sep;18(9):1509-17 [18550803] Ann N Y Acad Sci. 2008 Oct;1139:127-39 [18991857] PLoS One. 2014;9(1):e78644 [24454679] Genome Biol. 2014;15(12):550 [25516281] PLoS One. 2015;10(5):e0125045 [25946140] PLoS One. 2009;4(8):e6484 [19649296] J Exp Biol. 2010 Aug 15;213(Pt 16):2734-40 [20675542] Nat Immunol. 2010 Oct;11(10):889-96 [20856220] J Immunol. 2011 Mar 1;186(5):3047-57 [21307297] J Biotechnol. 2011 Feb 20;151(4):325-34 [21219943] Blood. 2011 Aug 18;118(7):1774-83 [21659548] BMC Bioinformatics. 2011;12:323 [21816040] BMC Genomics. 2012;13:28 [22257641] J Asthma. 2012 Apr;49(3):219-26 [22316092] Annu Rev Immunol. 2012;30:459-89 [22224774] BMC Genomics. 2012;13:250 [22708644] BMC Med Genomics. 2012;5:28 [22747986] J Clin Rheumatol. 2012 Dec;18(8):443-9 [23211587] Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21028-33 [23213261] Brain Behav Immun. 2013 Feb;28:159-69 [23201588] Blood. 2013 Mar 14;121(11):1951-60 [23293083] Cerebrovasc Dis. 2014;37(1):64-75 [24401164] Nat Biotechnol. 2014 Feb;32(2):111-2 [24509734] Biomark Med. 2014;8(2):297-306 [24521026] Int J Mol Med. 2014 Apr;33(4):777-83 [24535646] Dig Dis. 2014;32(1-2):102-6 [24603390] PLoS One. 2014;9(3):e91041 [24608128] Clin Rev Allergy Immunol. 2014 Apr;46(2):154-68 [24569953] BMC Bioinformatics. 2014;15:92 [24685233] Auton Neurosci. 2014 May;182:15-41 [24685093] Annu Rev Biochem. 2014;83:467-86 [24580643] Circ Res. 2014 Jun 20;115(1):165-75 [24951765] Immunol Rev. 2014 Sep;261(1):169-76 [25123284] Nat Biotechnol. 2014 Sep;32(9):915-25 [25150835] J Asthma. 2014 Oct;51(8):847-54 [24796647] Exp Cell Res. 2014 Dec 10;329(2):248-54 [25149680] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0133315 ER - TY - JOUR T1 - Rural Affordable Care Act Outreach and Enrollment: What We Learned During the First Marketplace Open Enrollment Period AN - 1695970946 AB - As part of the Patient Protection and Affordable Care Act (Affordable Care Act) of 2010, 2 new opportunities for health care coverage were established for many uninsured individuals beginning on January 1, 2014. The first opportunity was through Medicaid expansion where states had the opportunity to expand Medicaid coverage to individuals with household incomes up to 133% of the federal poverty level. The second opportunity was through the establishment of Health Insurance Marketplaces where individuals could purchase private health plans and potentially qualify for financial assistance in paying for their plans. The Office of Rural Health Policy (ORHP) provided supplemental grant awards to help stimulate Affordable Care Act outreach and education efforts in rural communities that were being served by the Rural Health Care Services Outreach (Outreach) Grant Program. As a result, Outreach grantees enrolled 9,300 rural Americans during the initial Open Enrollment period. Valuable outreach and enrollment lessons were learned from rural communities based on discussions with the Outreach grantees who received the supplemental funding. These lessons will help rural communities prepare for the next Open Enrollment period. JF - The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association AU - Kwon, Linda AD - Health Resources and Services Administration, Office of Rural Health Policy, Rockville, Maryland. ; Health Resources and Services Administration, Office of Rural Health Policy, Rockville, Maryland. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 1 EP - 3 CY - Washington PB - Wiley Subscription Services, Inc. VL - 31 IS - 1 SN - 0890-765X KW - Public Health And Safety KW - Coverage KW - Health Care Industry KW - Awards KW - Services KW - Poverty KW - Enrollment KW - Rural Communities KW - Health Care Services Policy KW - Health Insurance KW - Medicaid KW - Patients KW - Rural Areas KW - Rural Education KW - Uninsured Persons KW - Rural communities KW - Uninsured patients KW - Financing KW - Health care KW - Health insurance KW - Health policy KW - Insurance KW - Outreach programmes KW - Patient care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1695970946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.atitle=Rural+Affordable+Care+Act+Outreach+and+Enrollment%3A+What+We+Learned+During+the+First+Marketplace+Open+Enrollment+Period&rft.au=Kwon%2C+Linda&rft.aulast=Kwon&rft.aufirst=Linda&rft.date=2015-01-01&rft.volume=31&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fjrh.12100 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-06-28 DO - http://dx.doi.org/10.1111/jrh.12100 ER - TY - JOUR T1 - Antivibration Gloves: Effects on Vascular and Sensorineural Function, an Animal Model AN - 1691297042; PQ0001611320 AB - Anti-vibration gloves have been used to block the transmission of vibration from powered hand tools to the user, and to protect users from the negative health consequences associated with exposure to vibration. However, there are conflicting reports as to the efficacy of gloves in protecting workers. The goal of this study was to use a characterized animal model of vibration-induced peripheral vascular and nerve injury to determine whether antivibration materials reduced or inhibited the effects of vibration on these physiological symptoms. Rats were exposed to 4 h of tail vibration at 125 Hz with an acceleration 49 m/s super(2). The platform was either bare or covered with antivibrating glove material. Rats were tested for tactile sensitivity to applied pressure before and after vibration exposure. One day following the exposure, ventral tail arteries were assessed for sensitivity to vasodilating and vasoconstricting factors and nerves were examined histologically for early indicators of edema and inflammation. Ventral tail artery responses to an alpha 2C-adrenoreceptor agonist were enhanced in arteries from vibration-exposed rats compared to controls, regardless of whether antivibration materials were used or not. Rats exposed to vibration were also less sensitive to pressure after exposure. These findings are consistent with experimental findings in humans suggesting that antivibration gloves may not provide protection against the adverse health consequences of vibration exposure in all conditions. Additional studies need to be done examining newer antivibration materials. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Krajnak, K AU - Waugh, S AU - Johnson, C AU - Miller, R G AU - Welcome, D AU - Xu, X AU - Warren, C AU - Sarkisian, S AU - Andrew, M AU - Dong, R G AD - Engineering and Controls Technology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 571 EP - 582 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 78 IS - 9 SN - 1528-7394, 1528-7394 KW - Toxicology Abstracts KW - alpha 2C-Adrenergic receptors KW - Injuries KW - Tails KW - Arteries KW - Animal models KW - Edema KW - Hand KW - Inflammation KW - Nerves KW - Vibrations KW - Workers KW - Gloves KW - Pressure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691297042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Antivibration+Gloves%3A+Effects+on+Vascular+and+Sensorineural+Function%2C+an+Animal+Model&rft.au=Krajnak%2C+K%3BWaugh%2C+S%3BJohnson%2C+C%3BMiller%2C+R+G%3BWelcome%2C+D%3BXu%2C+X%3BWarren%2C+C%3BSarkisian%2C+S%3BAndrew%2C+M%3BDong%2C+R+G&rft.aulast=Krajnak&rft.aufirst=K&rft.date=2015-01-01&rft.volume=78&rft.issue=9&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2015.1014079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - alpha 2C-Adrenergic receptors; Injuries; Tails; Arteries; Animal models; Hand; Edema; Inflammation; Vibrations; Nerves; Workers; Gloves; Pressure DO - http://dx.doi.org/10.1080/15287394.2015.1014079 ER - TY - JOUR T1 - Evaluation of Diffuse Reflection Infrared Spectrometry for End-of-Shift Measurement of α-quartz in Coal Dust Samples. AN - 1691284326; 25636081 AB - The inhalation of toxic substances is a major threat to the health of miners, and dust containing respirable crystalline silica (α-quartz) is of particular concern, due to the recent rise in cases of coal workers' pneumoconiosis and silicosis in some U.S. mining regions. Currently, there is no field-portable instrument that can measure airborne α-quartz and give miners timely feedback on their exposure. The U.S. National Institute for Occupational Safety and Health (NIOSH) is therefore conducting studies to investigate technologies capable of end-of-shift or real-time measurement of airborne quartz. The present study focuses on the potential application of Fourier transform infrared (FT-IR) spectrometry conducted in the diffuse reflection (DR) mode as a technique for measuring α-quartz in respirable mine dust. A DR accessory was used to analyze lab-generated respirable samples of Min-U-Sil 5 (which contains more than 90% α-quartz) and coal dust, at mass loadings in the ranges of 100-600 μg and 600-5300 μg, respectively. The dust samples were deposited onto three different types of filters, borosilicate fiberglass, nylon, and polyvinyl chloride (PVC). The reflectance, R, was calculated by the ratio of a blank filter and a filter with deposited mine dust. Results suggest that for coal and pure quartz dusts deposited on 37 mm PVC filters, measurements of -log R correlate linearly with known amounts of quartz on filters, with R(2) values of approximately 0.99 and 0.94, respectively, for samples loaded up to ∼4000 μg. Additional tests were conducted to measure quartz in coal dusts deposited onto the borosilicate fiberglass and nylon filter media used in the NIOSH-developed Personal Dust Monitor (PDM). The nylon filter was shown to be amenable to DR analysis, but quantification of quartz is more accurate when the filter is "free," as opposed to being mounted in the PDM filter holder. The borosilicate fiberglass filters were shown to produce excessive interference, making quartz quantification impossible. It was concluded that, while the DR/FT-IR method is potentially useful for on-filter measurement of quartz in dust samples, the use of PVC filters produced the most accurate results. JF - Journal of occupational and environmental hygiene AU - Miller, Arthur L AU - Murphy, Nathaniel C AU - Bayman, Sean J AU - Briggs, Zachary P AU - Kilpatrick, Andrew D AU - Quinn, Courtney A AU - Wadas, Mackenzie R AU - Cauda, Emanuele G AU - Griffiths, Peter R AD - a Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health , Spokane , Washington. Y1 - 2015 PY - 2015 DA - 2015 SP - 421 EP - 430 VL - 12 IS - 7 KW - Air Pollutants, Occupational KW - 0 KW - Coal KW - Dust KW - Quartz KW - 14808-60-7 KW - Index Medicus KW - α-quartz KW - silica KW - coal dust KW - diffuse reflection spectrometry KW - United States KW - Air Filters KW - Coal Mining KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Exposure -- analysis KW - Spectroscopy, Fourier Transform Infrared -- methods KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Quartz -- analysis KW - Coal -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691284326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Evaluation+of+Diffuse+Reflection+Infrared+Spectrometry+for+End-of-Shift+Measurement+of+%CE%B1-quartz+in+Coal+Dust+Samples.&rft.au=Miller%2C+Arthur+L%3BMurphy%2C+Nathaniel+C%3BBayman%2C+Sean+J%3BBriggs%2C+Zachary+P%3BKilpatrick%2C+Andrew+D%3BQuinn%2C+Courtney+A%3BWadas%2C+Mackenzie+R%3BCauda%2C+Emanuele+G%3BGriffiths%2C+Peter+R&rft.aulast=Miller&rft.aufirst=Arthur&rft.date=2015-01-01&rft.volume=12&rft.issue=7&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1011328 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-25 N1 - Date created - 2015-06-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Occup Environ Med. 2005 Oct;62(10):670-4 [16169911] J Environ Monit. 2008 Jan;10(1):96-101 [18175022] J Environ Monit. 2008 May;10(5):671-8 [18449405] Am J Ind Med. 2008 Sep;51(9):633-9 [18626906] Ann Occup Hyg. 2009 Aug;53(6):639-49 [19531809] Ann Occup Hyg. 2010 Aug;54(6):697-709 [20660144] Appl Spectrosc. 2011 Mar;65(3):243-9 [21352643] Occup Environ Med. 2011 Dec;68(12):908-13 [21597107] J Environ Monit. 2012 Jan;14(1):48-55 [22130611] Anal Bioanal Chem. 2014 Jul;406(19):4715-24 [24830397] Am J Ind Med. 2003 Aug;44(2):141-7 [12874846] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2015.1011328 ER - TY - JOUR T1 - An Iterative Leave-One-Out Approach to Outlier Detection in RNA-Seq Data. AN - 1686413656; 26039068 AB - The discrete data structure and large sequencing depth of RNA sequencing (RNA-seq) experiments can often generate outlier read counts in one or more RNA samples within a homogeneous group. Thus, how to identify and manage outlier observations in RNA-seq data is an emerging topic of interest. One of the main objectives in these research efforts is to develop statistical methodology that effectively balances the impact of outlier observations and achieves maximal power for statistical testing. To reach that goal, strengthening the accuracy of outlier detection is an important precursor. Current outlier detection algorithms for RNA-seq data are executed within a testing framework and may be sensitive to sparse data and heavy-tailed distributions. Therefore, we propose a univariate algorithm that utilizes a probabilistic approach to measure the deviation between an observation and the distribution generating the remaining data and implement it within in an iterative leave-one-out design strategy. Analyses of real and simulated RNA-seq data show that the proposed methodology has higher outlier detection rates for both non-normalized and normalized negative binomial distributed data. JF - PloS one AU - George, Nysia I AU - Bowyer, John F AU - Crabtree, Nathaniel M AU - Chang, Ching-Wei AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, FDA, Jefferson, Arkansas, United States of America. ; Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, United States of America. ; Joint Bioinformatics Graduate Program, University of Arkansas at Little Rock and University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 6 KW - RNA KW - 63231-63-0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Sequence Analysis, DNA -- methods KW - Databases, Nucleic Acid KW - DNA -- genetics KW - Sequence Analysis, RNA -- methods KW - RNA -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686413656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=An+Iterative+Leave-One-Out+Approach+to+Outlier+Detection+in+RNA-Seq+Data.&rft.au=George%2C+Nysia+I%3BBowyer%2C+John+F%3BCrabtree%2C+Nathaniel+M%3BChang%2C+Ching-Wei&rft.aulast=George&rft.aufirst=Nysia&rft.date=2015-01-01&rft.volume=10&rft.issue=6&rft.spage=e0125224&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0125224 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-22 N1 - Date created - 2015-06-04 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Brief Bioinform. 2013 Nov;14(6):671-83 [22988256] PLoS One. 2013;8(12):e81415 [24349066] Nucleic Acids Res. 2014 Jun;42(11):e91 [24753412] Genome Biol. 2014;15(12):550 [25516281] Genome Res. 2008 Sep;18(9):1509-17 [18550803] Nature. 2008 Nov 27;456(7221):470-6 [18978772] Bioinformatics. 2010 Jan 1;26(1):139-40 [19910308] Genome Biol. 2010;11(3):R25 [20196867] BMC Bioinformatics. 2010;11:422 [20698981] Genome Biol. 2010;11(10):R106 [20979621] BMC Bioinformatics. 2011;12:449 [22087737] Biostatistics. 2013 Apr;14(2):232-43 [23001152] BMC Bioinformatics. 2013;14:91 [23497356] Stat Methods Med Res. 2013 Oct;22(5):519-36 [22127579] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0125224 ER - TY - JOUR T1 - Terminated Trials in the ClinicalTrials.gov Results Database: Evaluation of Availability of Primary Outcome Data and Reasons for Termination. AN - 1683759730; 26011295 AB - Clinical trials that end prematurely (or "terminate") raise financial, ethical, and scientific concerns. The extent to which the results of such trials are disseminated and the reasons for termination have not been well characterized. A cross-sectional, descriptive study of terminated clinical trials posted on the ClinicalTrials.gov results database as of February 2013 was conducted. The main outcomes were to characterize the availability of primary outcome data on ClinicalTrials.gov and in the published literature and to identify the reasons for trial termination. Approximately 12% of trials with results posted on the ClinicalTrials.gov results database (905/7,646) were terminated. Most trials were terminated for reasons other than accumulated data from the trial (68%; 619/905), with an insufficient rate of accrual being the lead reason for termination among these trials (57%; 350/619). Of the remaining trials, 21% (193/905) were terminated based on data from the trial (findings of efficacy or toxicity) and 10% (93/905) did not specify a reason. Overall, data for a primary outcome measure were available on ClinicalTrials.gov and in the published literature for 72% (648/905) and 22% (198/905) of trials, respectively. Primary outcome data were reported on the ClinicalTrials.gov results database and in the published literature more frequently (91% and 46%, respectively) when the decision to terminate was based on data from the trial. Trials terminate for a variety of reasons, not all of which reflect failures in the process or an inability to achieve the intended goals. Primary outcome data were reported most often when termination was based on data from the trial. Further research is needed to identify best practices for disseminating the experience and data resulting from terminated trials in order to help ensure maximal societal benefit from the investments of trial participants and others involved with the study. JF - PloS one AU - Williams, Rebecca J AU - Tse, Tony AU - DiPiazza, Katelyn AU - Zarin, Deborah A AD - National Library of Medicine (NLM), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 5 KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Outcome Assessment (Health Care) KW - Early Termination of Clinical Trials KW - Databases, Factual KW - Clinical Trials as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683759730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Terminated+Trials+in+the+ClinicalTrials.gov+Results+Database%3A+Evaluation+of+Availability+of+Primary+Outcome+Data+and+Reasons+for+Termination.&rft.au=Williams%2C+Rebecca+J%3BTse%2C+Tony%3BDiPiazza%2C+Katelyn%3BZarin%2C+Deborah+A&rft.aulast=Williams&rft.aufirst=Rebecca&rft.date=2015-01-01&rft.volume=10&rft.issue=5&rft.spage=e0127242&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0127242 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-18 N1 - Date created - 2015-05-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: BMJ. 2010;340:c869 [20332511] JAMA. 2014 Mar 12;311(10):1045-51 [24618966] J Clin Oncol. 2010 Dec 10;28(35):5197-201 [21060029] N Engl J Med. 2011 Mar 3;364(9):852-60 [21366476] Am J Bioeth. 2011 Mar;11(3):2-10 [21400374] Kennedy Inst Ethics J. 2011 Mar;21(1):51-78 [21598846] Acad Med. 2011 Nov;86(11):1360-6 [21952064] BMJ. 2012;344:d7292 [22214755] Clin Cancer Res. 2012 Jan 1;18(1):256-62 [21976533] JAMA. 2012 May 2;307(17):1838-47 [22550198] N Engl J Med. 2013 Nov 14;369(20):1926-34 [24224625] Ann Intern Med. 2014 Apr 1;160(7):477-83 [24687070] Am Heart J. 2014 Aug;168(2):213-9.e1 [25066561] J Natl Cancer Inst. 2014 Sep;106(9). pii: dju229. doi: 10.1093/jnci/dju229 [25190726] BMJ. 2014;349:g6870 [25491195] BMJ. 2014;349:g7089 [25499097] Clin Trials. 2015 Feb;12(1):77-83 [25475878] JAMA. 2014 Mar 12;311(10):1063-5 [24618969] JAMA. 2003 Apr 23-30;289(16):2128-31 [12709471] CMAJ. 2004 Sep 28;171(7):735-40 [15451835] Lancet. 1991 Apr 13;337(8746):867-72 [1672966] Circulation. 1994 Jun;89(6):2892-907 [8205706] JAMA. 2005 Nov 2;294(17):2203-9 [16264162] J Am Med Inform Assoc. 2007 May-Jun;14(3):253-63 [17329729] JAMA. 2007 May 16;297(19):2112-20 [17507347] N Engl J Med. 2008 Jan 17;358(3):252-60 [18199864] PLoS Med. 2008 Sep 23;5(9):e191 [18816163] Chest. 2009 Jul;136(1):295-303 [19584212] Chest. 2009 Jul;136(1):304-5 [19584213] J Oncol Pract. 2013 Nov;9(6):267-76 [24130252] PLoS Med. 2013 Dec;10(12):e1001566; discussion e1001566 [24311990] JAMA. 2010 Mar 24;303(12):1180-7 [20332404] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0127242 ER - TY - JOUR T1 - Post-translational structural modifications of immunoglobulin G and their effect on biological activity AN - 1680445221; PQ0001342384 AB - The size, heterogeneity, and biological production process of protein therapeutics like monoclonal, antibodies create unique challenges for their analysis and regulation compared with small molecules. Complete structural characterization of a molecule 1000-fold heavier than aspirin is no small feat. Biological post-translational modifications such as glycosylation further complicate their characterization and regulation. Even approved protein therapeutics are known to contain multiple structural variants in differing amounts. Structural modification occurs during production and storage as well as within patients after administration. Thus, the goals of manufacturers and regulators are to control and characterize this heterogeneity, not take on the impossible task of eliminating it. The aim of this review is to describe the structural heterogeneities known to occur with immunoglobulin G (IgG), note current detection and analytical strategies, establish their causes, and define their potential effects on the ultimate safety, purity, and potency of antibody therapeutics when known. JF - Analytical and Bioanalytical Chemistry AU - Hmiel, Laura K AU - Brorson, Kurt A AU - Boyne, Michael T, II AD - Center for Drug Evaluation and Research, Office of Testing and Research, Division of Pharmaceutical Analysis, United States Food and Drug Administration, Saint Louis, MO 63110, USA, michael.boyne@fda.hhs.gov PY - 2015 SP - 79 EP - 94 PB - Springer Science+Business Media VL - 407 IS - 1 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts; Immunology Abstracts KW - IgG KW - Post-translational modifications KW - Bioprocess KW - Monoclonal antibodies KW - Effector function KW - Safety KW - Glycosylation KW - Storage KW - Post-translation KW - Aspirin KW - Administration KW - Reviews KW - Immunoglobulin G KW - Proteins KW - Regulations KW - Heterogeneity KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680445221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Post-translational+structural+modifications+of+immunoglobulin+G+and+their+effect+on+biological+activity&rft.au=Hmiel%2C+Laura+K%3BBrorson%2C+Kurt+A%3BBoyne%2C+Michael+T%2C+II&rft.aulast=Hmiel&rft.aufirst=Laura&rft.date=2015-01-01&rft.volume=407&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-014-8108-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 183 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Aspirin; Post-translation; Monoclonal antibodies; Reviews; Immunoglobulin G; Glycosylation; Storage; Administration; Safety; Proteins; Regulations; Heterogeneity DO - http://dx.doi.org/10.1007/s00216-014-8108-x ER - TY - JOUR T1 - Approaches to studying and manipulating the enteric microbiome to improve autism symptoms. AN - 1680180280; 25956237 AB - There is a growing body of scientific evidence that the health of the microbiome (the trillions of microbes that inhabit the human host) plays an important role in maintaining the health of the host and that disruptions in the microbiome may play a role in certain disease processes. An increasing number of research studies have provided evidence that the composition of the gut (enteric) microbiome (GM) in at least a subset of individuals with autism spectrum disorder (ASD) deviates from what is usually observed in typically developing individuals. There are several lines of research that suggest that specific changes in the GM could be causative or highly associated with driving core and associated ASD symptoms, pathology, and comorbidities which include gastrointestinal symptoms, although it is also a possibility that these changes, in whole or in part, could be a consequence of underlying pathophysiological features associated with ASD. However, if the GM truly plays a causative role in ASD, then the manipulation of the GM could potentially be leveraged as a therapeutic approach to improve ASD symptoms and/or comorbidities, including gastrointestinal symptoms. One approach to investigating this possibility in greater detail includes a highly controlled clinical trial in which the GM is systematically manipulated to determine its significance in individuals with ASD. To outline the important issues that would be required to design such a study, a group of clinicians, research scientists, and parents of children with ASD participated in an interdisciplinary daylong workshop as an extension of the 1st International Symposium on the Microbiome in Health and Disease with a Special Focus on Autism (www.microbiome-autism.com). The group considered several aspects of designing clinical studies, including clinical trial design, treatments that could potentially be used in a clinical trial, appropriate ASD participants for the clinical trial, behavioral and cognitive assessments, important biomarkers, safety concerns, and ethical considerations. Overall, the group not only felt that this was a promising area of research for the ASD population and a promising avenue for potential treatment but also felt that further basic and translational research was needed to clarify the clinical utility of such treatments and to elucidate possible mechanisms responsible for a clinical response, so that new treatments and approaches may be discovered and/or fostered in the future. JF - Microbial ecology in health and disease AU - Frye, Richard E AU - Slattery, John AU - MacFabe, Derrick F AU - Allen-Vercoe, Emma AU - Parker, William AU - Rodakis, John AU - Adams, James B AU - Krajmalnik-Brown, Rosa AU - Bolte, Ellen AU - Kahler, Stephen AU - Jennings, Jana AU - James, Jill AU - Cerniglia, Carl E AU - Midtvedt, Tore AD - Division of Neurology, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA. ; Department of Psychology and Psychiatry, Western University, London, ON, Canada. ; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada. ; Department of Surgery, Duke University, Durham, NC USA. ; N of One: Autism Research Foundation, Dallas, TX, USA. ; School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, AZ, USA. ; Swette Center for Environmental Biotechnology, Biodesign Institute, Arizona State University, Tempe, AZ, USA. ; Private Practice, Benton, AR, USA. ; Department of Developmental Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA. ; National Center for Toxicological Research, Jefferson, AR, USA. ; MTC, Karolinska Institutet, Stockholm, Sweden. Y1 - 2015 PY - 2015 DA - 2015 SP - 26878 VL - 26 SN - 0891-060X, 0891-060X KW - short chain fatty acids KW - Clostridia KW - mitochondria KW - fecal microbiota transplantation (FMT) KW - probiotic KW - microbiome KW - vancomycin KW - autism spectrum disorder KW - clinical trials KW - gastrointestinal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680180280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+ecology+in+health+and+disease&rft.atitle=Approaches+to+studying+and+manipulating+the+enteric+microbiome+to+improve+autism+symptoms.&rft.au=Frye%2C+Richard+E%3BSlattery%2C+John%3BMacFabe%2C+Derrick+F%3BAllen-Vercoe%2C+Emma%3BParker%2C+William%3BRodakis%2C+John%3BAdams%2C+James+B%3BKrajmalnik-Brown%2C+Rosa%3BBolte%2C+Ellen%3BKahler%2C+Stephen%3BJennings%2C+Jana%3BJames%2C+Jill%3BCerniglia%2C+Carl+E%3BMidtvedt%2C+Tore&rft.aulast=Frye&rft.aufirst=Richard&rft.date=2015-01-01&rft.volume=26&rft.issue=&rft.spage=26878&rft.isbn=&rft.btitle=&rft.title=Microbial+ecology+in+health+and+disease&rft.issn=0891060X&rft_id=info:doi/10.3402%2Fmehd.v26.26878 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-09 N1 - Date created - 2015-05-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3402/mehd.v26.26878 ER - TY - JOUR T1 - Rural Affordable Care Act Outreach and Enrollment: What We Learned During the First Marketplace Open Enrollment Period AN - 1680147032; 2011-777185 AB - As part of the Patient Protection and Affordable Care Act (Affordable Care Act) of 2010, 2 new opportunities for health care coverage were established for many uninsured individuals beginning on January 1, 2014. The first opportunity was through Medicaid expansion where states had the opportunity to expand Medicaid coverage to individuals with household incomes up to 133% of the federal poverty level. The second opportunity was through the establishment of Health Insurance Marketplaces where individuals could purchase private health plans and potentially qualify for financial assistance in paying for their plans. The Office of Rural Health Policy (ORHP) provided supplemental grant awards to help stimulate Affordable Care Act outreach and education efforts in rural communities that were being served by the Rural Health Care Services Outreach (Outreach) Grant Program. As a result, Outreach grantees enrolled 9,300 rural Americans during the initial Open Enrollment period. Valuable outreach and enrollment lessons were learned from rural communities based on discussions with the Outreach grantees who received the supplemental funding. These lessons will help rural communities prepare for the next Open Enrollment period. Adapted from the source document. JF - The Journal of Rural Health AU - Kwon, Linda AD - Health Resources and Services Administration, Office of Rural Health Policy, Rockville, Maryland. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 1 EP - 3 PB - John Wiley & Sons, Inc. VL - 31 IS - 1 SN - 0890-765X, 0890-765X KW - Health conditions and policy - Health and health policy KW - Law and ethics - Law and jurisprudence KW - Health conditions and policy - Medicine and health care KW - Social conditions and policy - Public welfare and social services KW - Education and education policy - Education KW - Social conditions and policy - Rural conditions KW - Business and service sector - Insurance KW - Population groups, population policy, and demographics - Demography and census KW - Business and service sector - Accounting KW - Social conditions and policy - Social conditions and problems KW - Economic conditions and policy - Economic conditions KW - United States KW - Medicaid program KW - Health insurance KW - Patients KW - Income KW - Education KW - Uninsured persons KW - Poverty KW - Households KW - Health policy KW - Medical service KW - Rural education KW - Legislation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680147032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Rural+Affordable+Care+Act+Outreach+and+Enrollment%3A+What+We+Learned+During+the+First+Marketplace+Open+Enrollment+Period&rft.au=Kwon%2C+Linda&rft.aulast=Kwon&rft.aufirst=Linda&rft.date=2015-01-01&rft.volume=31&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fjrh.12100 LA - English DB - PAIS Index N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Health policy; Legislation; United States; Medical service; Medicaid program; Rural education; Health insurance; Education; Households; Income; Patients; Poverty; Uninsured persons DO - http://dx.doi.org/10.1111/jrh.12100 ER - TY - JOUR T1 - Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions AN - 1676358111; PQ0001427097 AB - Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus. JF - Journal of Immunology Research AU - Dowall, S D AU - Graham, V A AU - Corbin-Lickfett, K AU - Empig, C AU - Schlunegger, K AU - Bruce, C B AU - Easterbrook, L AU - Hewson, R AD - Public Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UK, stuart.dowall@phe.gov.uk Y1 - 2015/01// PY - 2015 DA - Jan 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-8861, 2314-8861 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Virions KW - Mortality KW - Antibodies KW - Immunology KW - Hemorrhagic fever KW - Ebola virus KW - Vaccines KW - Antiviral activity KW - F 06905:Vaccines KW - V 22350:Immunology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676358111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology+Research&rft.atitle=Effective+Binding+of+a+Phosphatidylserine-Targeting+Antibody+to+Ebola+Virus+Infected+Cells+and+Purified+Virions&rft.au=Dowall%2C+S+D%3BGraham%2C+V+A%3BCorbin-Lickfett%2C+K%3BEmpig%2C+C%3BSchlunegger%2C+K%3BBruce%2C+C+B%3BEasterbrook%2C+L%3BHewson%2C+R&rft.aulast=Dowall&rft.aufirst=S&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology+Research&rft.issn=23148861&rft_id=info:doi/10.1155%2F2015%2F347903 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 2 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Virions; Antibodies; Hemorrhagic fever; Vaccines; Antiviral activity; Mortality; Immunology; Ebola virus DO - http://dx.doi.org/10.1155/2015/347903 ER - TY - JOUR T1 - The Global Ecology and Epidemiology of West Nile Virus AN - 1676355989; PQ0001427376 AB - Since its initial isolation in Uganda in 1937 through the present, West Nile virus (WNV) has become an important cause of human and animal disease worldwide. WNV, an enveloped virus of the genus Flavivirus , is naturally maintained in an enzootic cycle between birds and mosquitoes, with occasional epizootic spillover causing disease in humans and horses. The mosquito vectors for WNV are widely distributed worldwide, and the known geographic range of WNV transmission and disease has continued to increase over the past 77 years. While most human infections with WNV are asymptomatic, severe neurological disease may develop resulting in long-term sequelae or death. Surveillance and preventive measures are an ongoing need to reduce the public health impact of WNV in areas with the potential for transmission. JF - BioMed Research International AU - Chancey, Caren AU - Grinev, Andriyan AU - Volkova, Evgeniya AU - Rios, Maria AD - United States Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD 20993-0002, USA, maria.rios@fda.hhs.gov Y1 - 2015/01// PY - 2015 DA - Jan 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Mortality KW - Neurological diseases KW - Complications KW - Horses KW - Vectors KW - Uganda KW - Epizootics KW - Infection KW - Flavivirus KW - Disease transmission KW - Public health KW - Aves KW - Ecology KW - Epidemiology KW - West Nile virus KW - Animal diseases KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - W 30965:Miscellaneous, Reviews KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676355989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=The+Global+Ecology+and+Epidemiology+of+West+Nile+Virus&rft.au=Chancey%2C+Caren%3BGrinev%2C+Andriyan%3BVolkova%2C+Evgeniya%3BRios%2C+Maria&rft.aulast=Chancey&rft.aufirst=Caren&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F376230 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 2 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Neurological diseases; Epidemiology; Complications; Vectors; Epizootics; Infection; Public health; Disease transmission; Ecology; Aves; Mortality; Horses; Animal diseases; West Nile virus; Flavivirus; Uganda DO - http://dx.doi.org/10.1155/2015/376230 ER - TY - JOUR T1 - Farm Work-Related Asthma Among US Primary Farm Operators AN - 1668272021; PQ0001114142 AB - The objective of this study was to estimate the prevalence of current asthma and the proportion of current asthma that is related to work on the farm among primary farm operators. The 2011 Farm and Ranch Safety Survey data were used to produce estimates and prevalence odds ratios. An estimated 5.1% of farm operators had asthma. Of these, 15.4% had farm work-related asthma. Among operators with farm work-related asthma, 54.8% (95% confidence interval [CI]: 41.8%-68.2%) had an asthma attack in the prior 12 months and 33.3% (95% CI: 21.2%-45.4%) had an asthma attack that occurred while doing farm work. Of those who had an asthma attack that occurred while doing farm work, 65.0% associated their asthma attack with plant/tree materials. This study provides updated information on asthma and the proportion of current asthma that is related to work on the farm and identifies certain groups of farm operators that might benefit from workplace asthma prevention intervention. JF - Journal of Agromedicine AU - Mazurek, Jacek M AU - White, Gretchen E AU - Rodman, Chad AU - Schleiff, Patricia L AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA PY - 2015 SP - 31 EP - 42 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 20 IS - 1 SN - 1059-924X, 1059-924X KW - Health & Safety Science Abstracts KW - Prevention KW - Farms KW - Trees KW - Safety KW - Asthma KW - Ranching KW - Intervention KW - Respiratory diseases KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668272021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=Farm+Work-Related+Asthma+Among+US+Primary+Farm+Operators&rft.au=Mazurek%2C+Jacek+M%3BWhite%2C+Gretchen+E%3BRodman%2C+Chad%3BSchleiff%2C+Patricia+L&rft.aulast=Mazurek&rft.aufirst=Jacek&rft.date=2015-01-01&rft.volume=20&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F1059924X.2014.976729 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Prevention; Farms; Trees; Safety; Intervention; Ranching; Asthma; Respiratory diseases DO - http://dx.doi.org/10.1080/1059924X.2014.976729 ER - TY - JOUR T1 - Vitamin D status and associated factors of deficiency among Jordanian children of preschool age AN - 1668256274; PQ0001182115 AB - Background/ Objectives: Vitamin D deficiency in children remains a global concern. Although literature exists on the vitamin D status and its risk factors among children in the Middle East, findings have yielded mixed results, and large, representative community studies are lacking.Subjects/ Methods: In a nationally representative survey of 1077 Jordanian children of preschool age (12-59 months) in Spring 2010, we measured 25(OH)D sub(3) concentrations by liquid chromatography-tandem mass spectrometry and calculated prevalence ratios for deficiency associated with various factors. Results: Results showed 19.8% (95% confidence interval (CI): 16.4-23.3%) deficiency (<12 ng/ml) and 56.5% (95% CI: 52.0-61.0%) insufficiency (<20 ng/ml). In adjusted models, prevalence of deficiency was higher for females compared with males (prevalence ratio (PR)=1.74, 95% CI: 1.22-2.47, P=0.002) and lower for children 24-35 months of age (PR=0.64, 95% CI: 0.44-0.92, P=0.018) compared with children 12-23 months of age. In rural areas, there was no difference in prevalence of vitamin D deficiency between those whose mothers had/did not have vitamin D deficiency (P=0.312); however, in urban areas, prevalence of vitamin D deficiency was 3.18 times greater among those whose mothers were vitamin D deficient compared with those whose mothers were not deficient (P=0.000). Conclusions: Vitamin D deficiency and insufficiency pose significant public health problems in Jordanian children with female children disproportionately affected. Strong associations between vitamin D status in children and urban residency and maternal vitamin D status suggest that the behaviors related to sun exposure in urban mothers likely also affect the sun exposure and thus vitamin D status of their children. JF - European Journal of Clinical Nutrition AU - Nichols, E K AU - Khatib, I M D AU - Aburto, N J AU - Serdula, M K AU - Scanlon, K S AU - Wirth, J P AU - Sullivan, K M AD - Epidemic Intelligence Service assigned to the Division of Nutrition, Physical Activity and Obesity, Centers for Disease Control and Prevention, U.S. Public Health Service, Atlanta, GA, USA Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 90 EP - 95 PB - Nature Publishing Group VL - 69 IS - 1 SN - 0954-3007, 0954-3007 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Vitamin D KW - Behavior KW - Risk factors KW - Sun KW - Mass spectrometry KW - Children KW - Middle East KW - Public health KW - Rural areas KW - Urban areas KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668256274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Nutrition&rft.atitle=Vitamin+D+status+and+associated+factors+of+deficiency+among+Jordanian+children+of+preschool+age&rft.au=Nichols%2C+E+K%3BKhatib%2C+I+M+D%3BAburto%2C+N+J%3BSerdula%2C+M+K%3BScanlon%2C+K+S%3BWirth%2C+J+P%3BSullivan%2C+K+M&rft.aulast=Nichols&rft.aufirst=E&rft.date=2015-01-01&rft.volume=69&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Nutrition&rft.issn=09543007&rft_id=info:doi/10.1038%2Fejcn.2014.142 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Age; Vitamin D; Behavior; Risk factors; Sun; Mass spectrometry; Children; Urban areas; Rural areas; Public health; Middle East DO - http://dx.doi.org/10.1038/ejcn.2014.142 ER - TY - JOUR T1 - ICD-11: A COMPREHENSIVE PICTURE OF HEALTH, AN UPDATE ON THE ICD-ICF JOINT USE INITIATIVE AN - 1665159992 AB - Background: This is a follow-up of the special report Towards the joint use of ICD and ICF: A call for contribution, published by the Journal of Rehabilitation Medicine in 2012, which introduced an initiative of using the International Classification of Diseases (ICD) and the International Classification of Functioning, Disability and Health (ICF) in a complementary way in clinical practice. Recognizing the merits of using the ICD and ICF jointly, the World Health Organization (WHO) introduced so-called functioning properties in the ICD-11. The first step in this ICD-ICF joint use initiative revealed 103 rehabilitation-relevant health conditions for which functioning properties were to be identified. Afterwards experts were recruited to identify the functioning properties for the health conditions for which no ICF Core Sets were available and all the functioning properties were integrated in the beta-version of ICD-11. Objective: The objective of this special report is to present the outcome of the recruitment and training of the contributing experts, and to provide an update on the current status of identifying functioning properties and their integration in ICD-11. Discussion: Having functioning properties in the ICD-11 achieves a milestone in depicting health information in an integrated and comprehensive manner. Explicitly identifying functioning properties for specific health conditions further reinforces the importance of acquiring a broader and more meaningful picture of a personʼs health, and can guide clinical decision-making. JF - Journal of Rehabilitation Medicine AU - Selb, Melissa AU - Kohler, Friedbert AU - Nicol, Molly Meri Robinson AU - Riberto, Marcelo AU - Stucki, Gerold AU - Kennedy, Cille AU - Ustun, Bedirhan AD - WHO Collaborating Centre for the Family of International Classifications in Germany (at DIMDI); Swiss Paraplegic Research, Nottwil, Switzerland; ICF Research Branch, c/o Swiss Paraplegic Research, Guido-Zach-Strasse 4, CH-6207 Nottwil, Switzerland ; Braeside Hospital, Wetherill Park; School of Public Health and Community Medicine, Faculty of Medicine, University of NSW, Sydney, Australia ; World Health Organization, Classification, Terminology and Standards, Geneva, Switzerland ; University of Sao Paulo, Ribeirao Medical School, Sao Paulo, Brazil ; ICF Research Branch; WHO Collaborating Centre for the Family of International Classifications in Germany (at DIMDI); Swiss Paraplegic Research, Nottwil, Switzerland; Department of Health Sciences and Health Policy, University of Lucerne; SPF, Nottwil, Switerzland ; US Department of Health and Human Services, Washington, USA ; WHO Collaborating Centre for the Family of International Classifications in Germany (at DIMDI); Swiss Paraplegic Research, Nottwil, Switzerland; ICF Research Branch, c/o Swiss Paraplegic Research, Guido-Zach-Strasse 4, CH-6207 Nottwil, Switzerland Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 2 EP - 8 CY - Stockholm PB - Taylor & Francis Ltd. VL - 47 IS - 1 SN - 1650-1977 KW - Medical Sciences KW - International Classification of Diseases KW - ICF KW - classification KW - functioning KW - ICD revision KW - rehabilitation KW - Classification KW - Conditions KW - Clinical decision making KW - Clinical practice KW - Decision making KW - Disability KW - Experts KW - Health information KW - Recruitment KW - Rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665159992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Medicine&rft.atitle=ICD-11%3A+A+COMPREHENSIVE+PICTURE+OF+HEALTH%2C+AN+UPDATE+ON+THE+ICD-ICF+JOINT+USE+INITIATIVE&rft.au=Selb%2C+Melissa%3BKohler%2C+Friedbert%3BNicol%2C+Molly+Meri+Robinson%3BRiberto%2C+Marcelo%3BStucki%2C+Gerold%3BKennedy%2C+Cille%3BUstun%2C+Bedirhan&rft.aulast=Selb&rft.aufirst=Melissa&rft.date=2015-01-01&rft.volume=47&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Medicine&rft.issn=16501977&rft_id=info:doi/10.2340%2F16501977-1928 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - World Health Organization N1 - Date revised - 2015-02-05 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.2340/16501977-1928 ER - TY - JOUR T1 - Introduction to Special Section: Behavioral Health and Disasters—Planning for the Next Time AN - 1665151449 JF - Journal of Behavioral Health Services & Research AU - Larson, Sharon AU - Gould, Deborah W AD - Substance Abuse and Mental Health Services Administration, Atlanta, GA, USA ; Centers for Disease Control and Prevention, Atlanta, GA, USA dgw8@cdc.gov; Substance Abuse and Mental Health Services Administration, Atlanta, GA, USA Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 3 EP - 5 CY - Gaithersburg PB - Springer Science & Business Media VL - 42 IS - 1 SN - 1094-3412 KW - Public Health And Safety KW - Disasters KW - Health behaviour UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665151449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Introduction+to+Special+Section%3A+Behavioral+Health+and+Disasters%E2%80%94Planning+for+the+Next+Time&rft.au=Larson%2C+Sharon%3BGould%2C+Deborah+W&rft.aulast=Larson&rft.aufirst=Sharon&rft.date=2015-01-01&rft.volume=42&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-014-9444-5 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.1007/s11414-014-9444-5 ER - TY - JOUR T1 - Epidemiologic Studies of Behavioral Health Following the Deepwater Horizon Oil Spill: Limited Impact or Limited Ability to Measure? AN - 1665151041 AB - Two large-scale epidemiologic federal surveys conducted in the Gulf Coast following the Deepwater Horizon oil spill and intended to measure its impact on mental disorders and substance use found less dramatic results than had been anticipated. However, several smaller-scale studies conducted shortly after the spill did find increases in the prevalence of certain psychological problems among individuals surveyed. Previous federal studies conducted following two disasters—the destruction of the World Trade Center (WTC) and Hurricanes Katrina and Rita—found few statistically significant changes in behavioral disorders in the wake of those events, except for individuals displaced from their homes by Katrina for 2 weeks or more. In this commentary, the authors discuss questions raised by these mixed results regarding the limitations of such studies, the behavioral health impact of the Deepwater Horizon spill compared to disasters causing more widespread loss of life and destruction of property, and the ways in which data collection following disasters might be improved to benefit public health planners. JF - Journal of Behavioral Health Services & Research AU - Teich, Judith L AU - Pemberton, Michael R AD - Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA judith.teich@samhsa.hhs.gov; RTI International, 3040 Cornwallis Road, Research Triangle Park, Durham, NC, 27709-2194, USA ; Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 77 EP - 85 CY - Gaithersburg PB - Springer Science & Business Media VL - 42 IS - 1 SN - 1094-3412 KW - Public Health And Safety KW - Behaviour disorders KW - Behavioural changes KW - Health behaviour KW - Destruction KW - Disasters KW - Hurricanes KW - Petroleum KW - Planners KW - Property KW - Psychiatric disorders KW - Psychological problems KW - Public health KW - World trade UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665151041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Epidemiologic+Studies+of+Behavioral+Health+Following+the+Deepwater+Horizon+Oil+Spill%3A+Limited+Impact+or+Limited+Ability+to+Measure%3F&rft.au=Teich%2C+Judith+L%3BPemberton%2C+Michael+R&rft.aulast=Teich&rft.aufirst=Judith&rft.date=2015-01-01&rft.volume=42&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-014-9395-x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - World Trade Center-New York City NY N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-25 DO - http://dx.doi.org/10.1007/s11414-014-9395-x ER - TY - JOUR T1 - Behavioral Health in the Gulf Coast Region Following the Deepwater Horizon Oil Spill: Findings from Two Federal Surveys AN - 1665150881 AB - This article summarizes findings from two large-scale, population-based surveys conducted by Substance Abuse and Mental Health Services Administration (SAMHSA) and Centers for Disease Control and Prevention (CDC) in the Gulf Coast region following the 2010 Deepwater Horizon oil spill, to measure the prevalence of mental and substance use disorders, chronic health conditions, and utilization of behavioral health services. Although many area residents undoubtedly experienced increased levels of anxiety and stress following the spill, findings suggest only modest or minimal changes in behavioral health at the aggregate level before and after the spill. The studies do not address potential long-term effects of the spill on physical and behavioral health nor did they target subpopulations that might have been most affected by the spill. Resources mobilized to reduce the economic and behavioral health impacts of the spill on coastal residents—including compensation for lost income from BP and increases in available mental health services—may have resulted in a reduction in potential mental health problems. JF - Journal of Behavioral Health Services & Research AU - Gould, Deborah W AU - Teich, Judith L AU - Pemberton, Michael R AU - Pierannunzi, Carol AU - Larson, Sharon AD - Division of Health Informatics and Surveillance, Centers for Disease Control and Prevention, Atlanta, Georgia ; Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA Judith.teich@samhsa.hhs.gov Judith.teich@samhsa.hhs.gov; RTI International, New Orleans, LA, USA ; Division of Health Informatics and Surveillance, Centers for Disease Control and Prevention, Atlanta, Georgia Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 6 EP - 22 CY - Gaithersburg PB - Springer Science & Business Media VL - 42 IS - 1 SN - 1094-3412 KW - Public Health And Safety KW - Chronic sickness KW - Behavioural changes KW - Health behaviour KW - Compensation KW - Health KW - Health problems KW - Health services KW - Health status KW - Long term effects KW - Mental health services KW - Mental illness KW - Petroleum KW - Psychiatric disorders KW - Social services KW - Substance abuse disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665150881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Behavioral+Health+in+the+Gulf+Coast+Region+Following+the+Deepwater+Horizon+Oil+Spill%3A+Findings+from+Two+Federal+Surveys&rft.au=Gould%2C+Deborah+W%3BTeich%2C+Judith+L%3BPemberton%2C+Michael+R%3BPierannunzi%2C+Carol%3BLarson%2C+Sharon&rft.aulast=Gould&rft.aufirst=Deborah&rft.date=2015-01-01&rft.volume=42&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-014-9441-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Centers for Disease Control & Prevention--CDC N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1007/s11414-014-9441-8 ER - TY - JOUR T1 - Modeling the interaction between quinolinate and the receptor for advanced glycation end products (RAGE): relevance for early neuropathological processes. AN - 1662636529; 25757085 AB - The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor involved in neurodegenerative and inflammatory disorders. RAGE induces cellular signaling upon binding to a variety of ligands. Evidence suggests that RAGE up-regulation is involved in quinolinate (QUIN)-induced toxicity. We investigated the QUIN-induced toxic events associated with early noxious responses, which might be linked to signaling cascades leading to cell death. The extent of early cellular damage caused by this receptor in the rat striatum was characterized by image processing methods. To document the direct interaction between QUIN and RAGE, we determined the binding constant (Kb) of RAGE (VC1 domain) with QUIN through a fluorescence assay. We modeled possible binding sites of QUIN to the VC1 domain for both rat and human RAGE. QUIN was found to bind at multiple sites to the VC1 dimer, each leading to particular mechanistic scenarios for the signaling evoked by QUIN binding, some of which directly alter RAGE oligomerization. This work contributes to the understanding of the phenomenon of RAGE-QUIN recognition, leading to the modulation of RAGE function. JF - PloS one AU - Serratos, Iris N AU - Castellanos, Pilar AU - Pastor, Nina AU - Millán-Pacheco, César AU - Rembao, Daniel AU - Pérez-Montfort, Ruy AU - Cabrera, Nallely AU - Reyes-Espinosa, Francisco AU - Díaz-Garrido, Paulina AU - López-Macay, Ambar AU - Martínez-Flores, Karina AU - López-Reyes, Alberto AU - Sánchez-García, Aurora AU - Cuevas, Elvis AU - Santamaria, Abel AD - Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, México D.F., México; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, SSA, México D.F., México. ; Departamento de Ingeniería Eléctrica, Universidad Autónoma Metropolitana-Iztapalapa, México D.F., México. ; Facultad de Ciencias, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México. ; Instituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México. ; Neuropatología, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, México D.F., México. ; Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F., México. ; Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, México D.F., México. ; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, SSA, México D.F., México. ; Laboratorio de Líquido Sinovial, Instituto Nacional de Rehabilitación, SSA, México D.F., México. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 3 KW - Advanced Glycosylation End Product-Specific Receptor KW - 0 KW - Ager protein, rat KW - Quinolinic Acid KW - F6F0HK1URN KW - Index Medicus KW - Animals KW - Molecular Docking Simulation KW - Brain -- pathology KW - Oxidative Stress KW - Neurodegenerative Diseases -- metabolism KW - Rats, Wistar KW - Neurodegenerative Diseases -- pathology KW - Brain -- metabolism KW - Protein Binding KW - Male KW - Quinolinic Acid -- chemistry KW - Quinolinic Acid -- physiology KW - Advanced Glycosylation End Product-Specific Receptor -- metabolism KW - Advanced Glycosylation End Product-Specific Receptor -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1662636529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Modeling+the+interaction+between+quinolinate+and+the+receptor+for+advanced+glycation+end+products+%28RAGE%29%3A+relevance+for+early+neuropathological+processes.&rft.au=Serratos%2C+Iris+N%3BCastellanos%2C+Pilar%3BPastor%2C+Nina%3BMill%C3%A1n-Pacheco%2C+C%C3%A9sar%3BRembao%2C+Daniel%3BP%C3%A9rez-Montfort%2C+Ruy%3BCabrera%2C+Nallely%3BReyes-Espinosa%2C+Francisco%3BD%C3%ADaz-Garrido%2C+Paulina%3BL%C3%B3pez-Macay%2C+Ambar%3BMart%C3%ADnez-Flores%2C+Karina%3BL%C3%B3pez-Reyes%2C+Alberto%3BS%C3%A1nchez-Garc%C3%ADa%2C+Aurora%3BCuevas%2C+Elvis%3BSantamaria%2C+Abel&rft.aulast=Serratos&rft.aufirst=Iris&rft.date=2015-01-01&rft.volume=10&rft.issue=3&rft.spage=e0120221&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0120221 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-13 N1 - Date created - 2015-03-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Allergy. 2013 Dec;68(12):1546-54 [24266677] Oncogene. 2014 Jan 30;33(5):567-77 [23318458] J Pathol. 2010 May;221(1):13-25 [20186922] Neurosci Lett. 2010 Apr 26;474(2):74-8 [20223279] Ann Med. 2009;41(6):408-22 [19322705] Structure. 2010 Oct 13;18(10):1342-52 [20947022] PLoS One. 2010;5(11):e14123 [21152063] J Biol Chem. 2010 Dec 24;285(52):40762-70 [20943659] J Mol Biol. 2011 Jan 7;405(1):158-72 [20970429] Biochim Biophys Acta. 2011 May;1814(5):592-609 [21354340] Structure. 2011 May 11;19(5):722-32 [21565706] J Chem Inf Model. 2011 Oct 24;51(10):2778-86 [21919503] J Biol Chem. 2012 Feb 10;287(7):5133-44 [22194616] Nat Rev Neurosci. 2012 Jul;13(7):465-77 [22678511] J Neurol Sci. 2012 Nov 15;322(1-2):187-91 [22749004] J Neurol Sci. 2012 Dec 15;323(1-2):1-8 [22939820] Cell Signal. 2013 Apr;25(4):939-54 [23333461] Neurotox Res. 2013 May;23(4):393-400 [23065398] ACS Chem Biol. 2013 Jul 19;8(7):1611-20 [23679870] Proteins. 2014 Mar;82(3):405-14 [24038671] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] Diabetes. 2001 Dec;50(12):2792-808 [11723063] J Neurochem. 2003 Jul;86(2):479-88 [12871589] Clin Chem Lab Med. 2003 Jul;41(7):852-9 [12940508] Biochemistry. 2004 Mar 23;43(11):3255-63 [15023076] PLoS One. 2014;9(3):e91512 [24632560] Mol Cell Biochem. 2014 May;390(1-2):271-80 [24510323] Circ J. 2014;78(5):1197-205 [24599045] J Exp Med. 2014 May 5;211(5):749-50 [24778420] Biochemistry. 2014 May 27;53(20):3327-35 [24824951] J Anat. 2004 Apr;204(4):271-81 [15061753] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] Neurochem Int. 2004 Dec;45(8):1175-83 [15380627] Biochemistry. 1982 May 25;21(11):2600-6 [7093207] Anal Biochem. 1982 Nov 15;127(1):159-63 [7165082] Life Sci. 1984 Jul 2;35(1):19-32 [6234446] Can Dis Wkly Rep. 1990 Sep;16 Suppl 1E:47-57; 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AN - 1661327326; 25738830 AB - Exposure to hard metal tungsten carbide cobalt (WC-Co) "dusts" in enclosed industrial environments is known to contribute to the development of hard metal lung disease and an increased risk for lung cancer. Currently, the influence of local and systemic inflammation on disease progression following WC-Co exposure remains unclear. To better understand the relationship between WC-Co nanoparticle (NP) exposure and its resultant effects, the acute local pulmonary and systemic inflammatory responses caused by WC-Co NPs were explored using an intra-tracheal instillation (IT) model and compared to those of CeO2 (another occupational hazard) NP exposure. Sprague-Dawley rats were given an IT dose (0-500 μg per rat) of WC-Co or CeO2 NPs. Following 24-hr exposure, broncho-alveolar lavage fluid and whole blood were collected and analyzed. A consistent lack of acute local pulmonary inflammation was observed in terms of the broncho-alveolar lavage fluid parameters examined (i.e. LDH, albumin, and macrophage activation) in animals exposed to WC-Co NP; however, significant acute pulmonary inflammation was observed in the CeO2 NP group. The lack of acute inflammation following WC-Co NP exposure contrasts with earlier in vivo reports regarding WC-Co toxicity in rats, illuminating the critical role of NP dose and exposure time and bringing into question the potential role of impurities in particle samples. Further, we demonstrated that WC-Co NP exposure does not induce acute systemic effects since no significant increase in circulating inflammatory cytokines were observed. Taken together, the results of this in vivo study illustrate the distinct differences in acute local pulmonary and systemic inflammatory responses to NPs composed of WC-Co and CeO2; therefore, it is important that the outcomes of pulmonary exposure to one type of NPs may not be implicitly extrapolated to other types of NPs. JF - PloS one AU - Armstead, Andrea L AU - Minarchick, Valerie C AU - Porter, Dale W AU - Nurkiewicz, Timothy R AU - Li, Bingyun AD - Biomaterials, Bioengineering & Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Pharmaceutical and Pharmacological Sciences Graduate Program, School of Pharmacy, West Virginia University, Morgantown, West Virginia, United States of America. ; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Center for Cardiovascular and Respiratory Sciences, Robert C. Byrd Health Sciences Center, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America. ; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America. ; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Center for Cardiovascular and Respiratory Sciences, Robert C. Byrd Health Sciences Center, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America. ; Biomaterials, Bioengineering & Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Pharmaceutical and Pharmacological Sciences Graduate Program, School of Pharmacy, West Virginia University, Morgantown, West Virginia, United States of America; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America; Mary Babb Randolph Cancer Center, Morgantown, West Virginia, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 3 KW - Interleukin-6 KW - 0 KW - Tumor Necrosis Factor-alpha KW - Tungsten Compounds KW - tungsten carbide KW - 11130-73-7 KW - Cobalt KW - 3G0H8C9362 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Cobalt -- chemistry KW - Interleukin-6 -- metabolism KW - Inflammation -- chemically induced KW - Toxicity Tests, Acute KW - Bronchoalveolar Lavage KW - Inflammation -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Male KW - Tungsten Compounds -- chemistry KW - Pneumonia -- chemically induced KW - Trachea KW - Nanoparticles -- toxicity KW - Pneumonia -- pathology KW - Pneumonia -- metabolism KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1661327326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Acute+inflammatory+responses+of+nanoparticles+in+an+intra-tracheal+instillation+rat+model.&rft.au=Armstead%2C+Andrea+L%3BMinarchick%2C+Valerie+C%3BPorter%2C+Dale+W%3BNurkiewicz%2C+Timothy+R%3BLi%2C+Bingyun&rft.aulast=Armstead&rft.aufirst=Andrea&rft.date=2015-01-01&rft.volume=10&rft.issue=3&rft.spage=e0118778&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0118778 LA - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0118778 ER - TY - JOUR T1 - Relationships Between Clinico-Epidemiological Patterns of Invasive Meningococcal Infections and Complement Deficiencies in French South Pacific Islands (New Caledonia) AN - 1660435286; PQ0001029016 AB - Purpose: Invasive Meningococcal Disease (IMD) is three fold more common in New Caledonia (NC) than in metropolitan France and many IMD cases (35.7 %) are due to Y and W135 serogroups. The purpose of our study was to identify IMD risk factors in NC. Methods: A retrospective study of all IMD cases that occurred in NC between 2005 and 2011 was conducted. Socio-environmental, clinical and biological data were collected. A search for immune deficiency was proposed to all cases. IMD presentation and outcome were compared according to meningoccal serogroups and the complement deficiency status (C-deficiency). Results: Sixty-six sporadic IMD cases (29 B serogroup, 20 Y or W135, 6 C, 1 A, 10 unknown) occurred in 64 patients often <24 years-old and of Melanesian origin. Five patients died (7.8 %). No socio-environmental risk factors were identified. No asplenia, HIV infection or immunoglobulin deficiencies were found. Two patients had diabetes and 28 of 53 (52.8 %) patients had C-deficiency including 20 (71.4 %) cases of late complement component deficiency. Patients with C-deficiency were mainly Melanesian (92.8 %) originating from the Loyalty Islands (62.1 %). They were mostly infected with Y/W135 (42.9 %) or B serogroups (32.1 %). They often developed later and more severe disease than patients without C-deficiency (need for intensive cares in 60 % versus 28.0 % of cases, p=0.01). Conclusions: A high prevalence of C-deficiency in the Melanesian population may explain epidemiological and clinical features of IMD in NC. Our results imply an adaptation of meningococcal vaccine strategies in NC. JF - Journal of Clinical Immunology AU - Daures, Maguy AU - John, Michele AU - Balter, Cecile Veysseyre AU - Simon, Olivier AU - Barguil, Yann AU - Missotte, Isabelle AU - Grangeon, Jean-Paul AU - Laumond-Barny, Sylvie AU - Noel, Martine AU - Besson-Leaud, Laurent AU - Spasic, Pierre-Emmanuel AU - Suremain, Aurelie AU - Gourinat, Ann-Claire AU - Descloux, Elodie AD - Public Health Service, New Caledonia Health Department, BP N4 - 98851, Noumea, Cedex, New Caledonia, maguy.daures@gmail.com Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 47 EP - 55 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 35 IS - 1 SN - 0271-9142, 0271-9142 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Data processing KW - Adaptations KW - Asplenia KW - Neisseria meningitidis KW - Infection KW - Diabetes mellitus KW - Islands KW - Human immunodeficiency virus KW - Risk factors KW - Invasive meningococcal disease KW - Complement deficiency KW - Vaccines KW - Immunoglobulins KW - J 02400:Human Diseases KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660435286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Immunology&rft.atitle=Relationships+Between+Clinico-Epidemiological+Patterns+of+Invasive+Meningococcal+Infections+and+Complement+Deficiencies+in+French+South+Pacific+Islands+%28New+Caledonia%29&rft.au=Daures%2C+Maguy%3BJohn%2C+Michele%3BBalter%2C+Cecile+Veysseyre%3BSimon%2C+Olivier%3BBarguil%2C+Yann%3BMissotte%2C+Isabelle%3BGrangeon%2C+Jean-Paul%3BLaumond-Barny%2C+Sylvie%3BNoel%2C+Martine%3BBesson-Leaud%2C+Laurent%3BSpasic%2C+Pierre-Emmanuel%3BSuremain%2C+Aurelie%3BGourinat%2C+Ann-Claire%3BDescloux%2C+Elodie&rft.aulast=Daures&rft.aufirst=Maguy&rft.date=2015-01-01&rft.volume=35&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Immunology&rft.issn=02719142&rft_id=info:doi/10.1007%2Fs10875-014-0104-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 38 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Adaptations; Data processing; Islands; Invasive meningococcal disease; Risk factors; Complement deficiency; Asplenia; Vaccines; Infection; Immunoglobulins; Human immunodeficiency virus; Neisseria meningitidis DO - http://dx.doi.org/10.1007/s10875-014-0104-6 ER - TY - JOUR T1 - A reliable multiplex genotyping assay for HCV using a suspension bead array AN - 1660402350; PQ0001007980 AB - The genotyping of the hepatitis C virus (HCV) plays an important role in the treatment of HCV because genotype determination has recently been incorporated into the treatment guidelines for HCV infections. Most current genotyping methods are unable to detect mixed genotypes from two or more HCV infections. We therefore developed a multiplex genotyping assay to determine HCV genotypes using a bead array. Synthetic plasmids, genotype panels and standards were used to verify the target-specific primer (TSP) design in the assay, and the results indicated that discrimination efforts using 10 TSPs in a single reaction were extremely successful. Thirty-five specimens were then tested to evaluate the assay performance, and the results were highly consistent with those of direct sequencing, supporting the reliability of the assay. Moreover, the results from samples with mixed HCV genotypes revealed that the method is capable of detecting two different genotypes within a sample. Furthermore, the specificity evaluation results suggested that the assay could correctly identify HCV in HCV/human immunodeficiency virus (HIV) co-infected patients. This genotyping platform enables the simultaneous detection and identification of more than one genotype in a same sample and is able to test 96 samples simultaneously. It could therefore provide a rapid, efficient and reliable method of determining HCV genotypes in the future. This genotyping platform enables the simultaneous detection and identification of more than one genotype in a same sample and is able to test 96 samples simultaneously. It could therefore provide a rapid, efficient, and reliable method of determining HCV genotypes in the future. JF - Microbial Biotechnology AU - Yang, Yi-Chen AU - Wang, Der-Yuan AU - Cheng, Hwei-Fang AU - Chuang, Eric Y AU - Tsai, Mong-Hsun AD - Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 93 EP - 102 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ United Kingdom VL - 8 IS - 1 SN - 1751-7915, 1751-7915 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Hepatitis C virus KW - Human immunodeficiency virus KW - Genotyping KW - Primers KW - Genotypes KW - Infection KW - Plasmids KW - A 01340:Antibiotics & Antimicrobials KW - G 07880:Human Genetics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660402350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Biotechnology&rft.atitle=A+reliable+multiplex+genotyping+assay+for+HCV+using+a+suspension+bead+array&rft.au=Yang%2C+Yi-Chen%3BWang%2C+Der-Yuan%3BCheng%2C+Hwei-Fang%3BChuang%2C+Eric+Y%3BTsai%2C+Mong-Hsun&rft.aulast=Yang&rft.aufirst=Yi-Chen&rft.date=2015-01-01&rft.volume=8&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Microbial+Biotechnology&rft.issn=17517915&rft_id=info:doi/10.1111%2F1751-7915.12140 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Genotyping; Primers; Genotypes; Plasmids; Infection; Hepatitis C virus; Human immunodeficiency virus DO - http://dx.doi.org/10.1111/1751-7915.12140 ER - TY - JOUR T1 - Use of Pharmacotherapies in the Treatment of Alcohol Use Disorders and Opioid Dependence in Primary Care AN - 1660400170; PQ0001106697 AB - Substance-related and addictive disorders are chronic relapsing conditions that substantially impact public health. Effective treatments for these disorders require addressing substance use/dependence comprehensively as well as other associated comorbidities. Comprehensive addressing of substance use in a medical setting involves screening for substance use, addressing substance use directly with the patient, and formulating an appropriate intervention. For alcohol dependence and opioid dependence, pharmacotherapies are available that are safe and effective when utilized in a comprehensive treatment paradigm, such as medication assisted treatment. In primary care, substance use disorders involving alcohol, illicit opioids, and prescription opioid abuse are common among patients who seek primary care services. Primary care providers report low levels of preparedness and confidence in identifying substance-related and addictive disorders and providing appropriate care and treatment. However, new models of service delivery in primary care for individuals with substance-related and addictive disorders are being developed to promote screening, care and treatment, and relapse prevention. The education and training of primary care providers utilizing approved medications for the treatment of alcohol use disorders and opioid dependence in a primary care setting would have important public health impact and reduce the burden of alcohol abuse and opioid dependence. JF - BioMed Research International AU - Lee, Jinhee AU - Kresina, Thomas F AU - Campopiano, Melinda AU - Lubran, Robert AU - Clark, HWestley AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA, jinhee.lee@samhsa.hhs.gov Y1 - 2015/01// PY - 2015 DA - Jan 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Biotechnology and Bioengineering Abstracts KW - Drug dependence KW - Opioids KW - Addiction KW - Drug abuse KW - Ethanol KW - Public health KW - Models KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660400170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Use+of+Pharmacotherapies+in+the+Treatment+of+Alcohol+Use+Disorders+and+Opioid+Dependence+in+Primary+Care&rft.au=Lee%2C+Jinhee%3BKresina%2C+Thomas+F%3BCampopiano%2C+Melinda%3BLubran%2C+Robert%3BClark%2C+HWestley&rft.aulast=Lee&rft.aufirst=Jinhee&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F137020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 6 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Drug dependence; Opioids; Addiction; Drug abuse; Models; Public health; Ethanol DO - http://dx.doi.org/10.1155/2015/137020 ER - TY - JOUR T1 - Debilitating Lung Disease Among Surface Coal Miners With No Underground Mining Tenure AN - 1660394415; PQ0001169716 AB - Objective: To characterize exposure histories and respiratory disease among surface coal miners identified with progressive massive fibrosis from a 2010 to 2011 pneumoconiosis survey. Methods: Job history, tenure, and radiograph interpretations were verified. Previous radiographs were reviewed when available. Telephone follow-up sought additional work and medical history information. Results: Among eight miners who worked as drill operators or blasters for most of their tenure (median, 35.5 years), two reported poor dust control practices, working in visible dust clouds as recently as 2012. Chest radiographs progressed to progressive massive fibrosis in as few as 11 years. One miner's lung biopsy demonstrated fibrosis and interstitial accumulation of macrophages containing abundant silica, aluminum silicate, and titanium dust particles. Conclusions: Overexposure to respirable silica resulted in progressive massive fibrosis among current surface coal miners with no underground mining tenure. Inadequate dust control during drilling/blasting is likely an important etiologic factor. JF - Journal of Occupational and Environmental Medicine AU - Halldin, Cara N AU - Reed, William R AU - Joy, Gerald J AU - Colinet, Jay F AU - Rider, James P AU - Petsonk, Edward L AU - Abraham, Jerrold L AU - Wolfe, Anita L AU - Storey, Eileen AU - Laney, A Scott AD - Surveillance Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WVa, challdin@cdc.gov Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 62 EP - 67 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 1 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Historical account KW - Dust clouds KW - Occupational safety KW - Pneumoconiosis KW - Respiratory diseases KW - Coal KW - Particulates KW - Dust KW - Silica KW - Lung KW - Reviews KW - Aluminum KW - Blasting KW - Mining KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660394415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Debilitating+Lung+Disease+Among+Surface+Coal+Miners+With+No+Underground+Mining+Tenure&rft.au=Halldin%2C+Cara+N%3BReed%2C+William+R%3BJoy%2C+Gerald+J%3BColinet%2C+Jay+F%3BRider%2C+James+P%3BPetsonk%2C+Edward+L%3BAbraham%2C+Jerrold+L%3BWolfe%2C+Anita+L%3BStorey%2C+Eileen%3BLaney%2C+A+Scott&rft.aulast=Halldin&rft.aufirst=Cara&rft.date=2015-01-01&rft.volume=57&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000302 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Historical account; Occupational safety; Dust clouds; Pneumoconiosis; Particulates; Coal; Respiratory diseases; Dust; Silica; Lung; Reviews; Aluminum; Blasting; Mining DO - http://dx.doi.org/10.1097/JOM.0000000000000302 ER - TY - JOUR T1 - Rapid Identification of Major Escherichia coli Sequence Types Causing Urinary Tract and Bloodstream Infections AN - 1660393233; 21328475 AB - Escherichia coli sequence types (STs) 69, 73, 95, and 131 are collectively responsible for a large proportion of E. coli urinary tract and bloodstream infections, and they differ markedly in their antibiotic susceptibilities. Here, we describe a novel PCR method to rapidly detect and distinguish these lineages. Three hundred eighteen published E. coli genomes were compared in order to identify signature sequences unique to each of the four major STs. The specificities of these sequences were assessed in silico by seeking them in an additional 98 genomes. A PCR assay was designed to amplify size-distinguishable fragments unique to the four lineages and was validated using 515 E. coli isolates of known STs. Genome comparisons identified 22 regions ranging in size from 335 bp to 26.5 kb that are unique to one or more of the four predominant E. coli STs, with two to 10 specific regions per ST. These regions predominantly harbor genes encoding hypothetical proteins and are within or adjacent to prophage sequences. Most (13/22) were highly conserved (>96.5% identity) in the genomes of their respective ST. The new assay correctly identified all 142 representatives of the four major STs in the validation set (n = 515), with only two ST12 isolates misidentified as ST95. Compared with MLST, the assay has 100% sensitivity and 99.5% specificity. The rapid identification of major extraintestinal E. coli STs will benefit future epidemiological studies and could be developed to tailor antibiotic therapy to the different susceptibilities of these dominant lineages. JF - Journal of Clinical Microbiology AU - Doumith, M AU - Day, M AU - Ciesielczuk, H AU - Hope, R AU - Underwood, A AU - Reynolds, R AU - Wain, J AU - Livermore, D M AU - Woodford, N AD - Public Health England, London, United Kingdom, michel.doumith@phe.gov.uk. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 160 EP - 166 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 1 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Genomes KW - Escherichia coli KW - Polymerase chain reaction KW - Antibiotics KW - Urinary tract KW - Infection KW - Prophages KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660393233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Rapid+Identification+of+Major+Escherichia+coli+Sequence+Types+Causing+Urinary+Tract+and+Bloodstream+Infections&rft.au=Doumith%2C+M%3BDay%2C+M%3BCiesielczuk%2C+H%3BHope%2C+R%3BUnderwood%2C+A%3BReynolds%2C+R%3BWain%2C+J%3BLivermore%2C+D+M%3BWoodford%2C+N&rft.aulast=Doumith&rft.aufirst=M&rft.date=2015-01-01&rft.volume=53&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.02562-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 24 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Genomes; Polymerase chain reaction; Antibiotics; Urinary tract; Infection; Prophages; Escherichia coli DO - http://dx.doi.org/10.1128/JCM.02562-14 ER - TY - JOUR T1 - Bioaccumulation of hepatotoxins - A considerable risk in the Latvian environment AN - 1660068136; 21291133 AB - The Gulf of Riga, river Daugava and several interconnected lakes around the City of Riga, Latvia, form a dynamic brackish-freshwater system favouring occurrence of toxic cyanobacteria. We examined bioaccumulation of microcystins and nodularin-R in aquatic organisms in Latvian lakes, the Gulf of Riga and west coast of open Baltic Sea in 2002-2007. The freshwater unionids accumulated toxins efficiently, followed by snails. In contrast, Dreissena polymorpha and most lake fishes (except roach) accumulated much less hepatotoxins. Significant nodularin-R concentrations were detected also in marine clams and flounders. No transfer of nodularin-R and microcystins between lake and brackish water systems took place. Lake mussels can transfer hepatotoxins to higher organisms, and also effectively remove toxins from the water column. Obvious health risks to aquatic organisms and humans are discussed. JF - Environmental Pollution AU - Barda, Ieva AU - Kankaanpaeae, Harri AU - Purina, Ingrida AU - Balode, Maija AU - Sjovall, Olli AU - Meriluoto, Jussi AD - Latvian Institute of Aquatic Ecology, 8 Daugavgrivas Str., LV-1048 Riga, Latvia PY - 2015 SP - 313 EP - 320 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 196 SN - 0269-7491, 0269-7491 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Hepatotoxins KW - Bioaccumulation KW - Invertebrates KW - Fish KW - Health risks KW - Risk KW - Organisms KW - Lakes KW - Dynamical systems KW - Gulfs KW - Toxins KW - Dynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660068136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Pollution&rft.atitle=Bioaccumulation+of+hepatotoxins+-+A+considerable+risk+in+the+Latvian+environment&rft.au=Barda%2C+Ieva%3BKankaanpaeae%2C+Harri%3BPurina%2C+Ingrida%3BBalode%2C+Maija%3BSjovall%2C+Olli%3BMeriluoto%2C+Jussi&rft.aulast=Barda&rft.aufirst=Ieva&rft.date=2015-01-01&rft.volume=196&rft.issue=&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Environmental+Pollution&rft.issn=02697491&rft_id=info:doi/10.1016%2Fj.envpol.2014.10.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-02-03 DO - http://dx.doi.org/10.1016/j.envpol.2014.10.024 ER - TY - JOUR T1 - Aerosolization of Respirable Droplets from a Domestic Spa Pool and the Use of MS-2 Coliphage and Pseudomonas aeruginosa as Markers for Legionella pneumophila AN - 1654695341; 21328329 AB - Legionnaires' disease can result when droplets or aerosols containing legionella bacteria are inhaled and deposited in the lungs. A number of outbreaks have been associated with the use of a spa pool where aeration, a high water temperature, and a large and variable organic load make disinfectant levels difficult to maintain. Spa pool ownership is increasing, and the aim of this study, using two surrogate organisms (MS-2 coliphage and Pseudomonas aeruginosa [a natural contaminant]), was to assess the potential risk to domestic users when disinfection fails. A representative "entry level" domestic spa pool was installed in an outdoor courtyard. The manufacturer's instructions for spa pool maintenance were not followed. A cyclone sampler was used to sample the aerosols released from the spa pool with and without activation of the air injection system. Samples were taken at increasing heights and distances from the pool. An aerodynamic particle sizer was used to measure the water droplet size distribution at each sample point. When the air injection system was inactivated, neither surrogate organism was recovered from the air. On activation of the air injection system, the mean mass of droplets within the respirable range (10 cm above the water line) was 36.8 mu g cm-3. This corresponded to a mean air concentration of P. aeruginosa of 350 CFU m-3. From extrapolation from animal data, the estimated risk of infection from aerosols contaminated with similar concentrations of Legionella pneumophila was 0.76 (males) and 0.65 (females). At 1 m above and/or beyond the pool, the mean aerosol mass decreased to 0.04 mu g cm-3 and corresponded to a 100-fold reduction in mean microbial air concentration. The estimated risk of infection at this distance was negligible. JF - Applied and Environmental Microbiology AU - Moore, Ginny AU - Hewitt, Matthew AU - Stevenson, David AU - Walker, Jimmy T AU - Bennett, Allan M PY - 2015 SP - 555 EP - 561 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 2 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cyclones KW - Legionella pneumophila KW - Disinfection KW - Aerosols KW - Data processing KW - Water temperature KW - Infection KW - Aeration KW - Samplers KW - Disinfectants KW - Injection systems KW - Colony-forming cells KW - Pseudomonas aeruginosa KW - Contaminants KW - Size distribution KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654695341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Aerosolization+of+Respirable+Droplets+from+a+Domestic+Spa+Pool+and+the+Use+of+MS-2+Coliphage+and+Pseudomonas+aeruginosa+as+Markers+for+Legionella+pneumophila&rft.au=Moore%2C+Ginny%3BHewitt%2C+Matthew%3BStevenson%2C+David%3BWalker%2C+Jimmy+T%3BBennett%2C+Allan+M&rft.aulast=Moore&rft.aufirst=Ginny&rft.date=2015-01-01&rft.volume=81&rft.issue=2&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02912-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 35 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Cyclones; Disinfection; Aerosols; Data processing; Water temperature; Infection; Samplers; Aeration; Injection systems; Disinfectants; Colony-forming cells; Contaminants; Size distribution; Legionella pneumophila; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1128/AEM.02912-14 ER - TY - JOUR T1 - Antibiotic Use before Chlamydia and Gonorrhea Genital and Extragenital Screening in the Sexually Transmitted Infection Clinical Setting AN - 1654694134; 21328160 AB - Background antibiotic use (i.e., administration of antibiotics not directly related to Chlamydia trachomatis or Neisseria gonorrhoeae infections) has been associated with a lower prevalence of genital C. trachomatis infection in a clinical setting. Associations with specific antibiotic types or with N. gonorrhoeae are lacking. Here, we assessed the prevalence of antibiotic use, the different classes and agents used, and their association with a subsequent sexually transmitted infection (STI) clinic C. trachomatis and N. gonorrhoeae test result. At our STI clinic, we systematically registered whether antibiotics were used in the past month (in 29% of the cases, the specific antibiotic agent was named). Patients were screened for urogenital C. trachomatis and N. gonorrhoeae; a third of them were also screened for anorectal and oropharyngeal C. trachomatis and N. gonorrhoeae. The proportion of antibiotics used and their association with C. trachomatis and N. gonorrhoeae prevalence were assessed for heterosexual men, men who have sex with men (MSM), and women. During 14,775 clinic consultations, antibiotic use was reported by 12.2% (95% confidence interval [CI], 11.7% to 12.7%), i.e., 14.8% of women, 8.6% of heterosexual men, and 11.6% of MSM. The most reported antibiotics were penicillins, tetracyclines, and macrolides, respectively. The prevalence was 11.0% (95% CI, 10.3% to 11.3%) for C. trachomatis and 1.9% (95% CI, 1.7% to 2.1%) for N. gonorrhoeae. Only tetracycline use was associated with a lower C. trachomatis prevalence (3%). Overall antibiotic use was associated with lower anorectal C. trachomatis prevalence in MSM only (odds ratio, 0.4; 95% CI, 0.2 to 0.8). STI clinic visitors commonly report recent antibiotic use. Even in a country with low antibiotic consumption, tetracycline use impacted C. trachomatis prevalence, while there was a notable absence of association with azithromycin. JF - Antimicrobial Agents & Chemotherapy AU - Dukers-Muijrers, Nicole HTM AU - van Liere, Genevieve AFS AU - Wolffs, Petra FG AU - Heijer, Casper Den AU - Werner, Marita ILS AU - Hoebe, Christian JPA AD - Department of Sexual Health, Infectious Diseases and Environmental Health, South Limburg Public Health Service, Geleen, the Netherlands, Nicole.dukers@ggdzl.nl. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 121 EP - 128 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Azithromycin KW - Chlamydia trachomatis KW - Antibiotics KW - Gonorrhea KW - Anorectal KW - Infection KW - Tetracyclines KW - Neisseria gonorrhoeae KW - Penicillin KW - Sex KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654694134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Antibiotic+Use+before+Chlamydia+and+Gonorrhea+Genital+and+Extragenital+Screening+in+the+Sexually+Transmitted+Infection+Clinical+Setting&rft.au=Dukers-Muijrers%2C+Nicole+HTM%3Bvan+Liere%2C+Genevieve+AFS%3BWolffs%2C+Petra+FG%3BHeijer%2C+Casper+Den%3BWerner%2C+Marita+ILS%3BHoebe%2C+Christian+JPA&rft.aulast=Dukers-Muijrers&rft.aufirst=Nicole&rft.date=2015-01-01&rft.volume=59&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.03932-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 23 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Azithromycin; Gonorrhea; Antibiotics; Anorectal; Tetracyclines; Infection; Penicillin; Sex; Chlamydia trachomatis; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1128/AAC.03932-14 ER - TY - JOUR T1 - Injection site infections and injuries in men who inject image- and performance-enhancing drugs: prevalence, risks factors, and healthcare seeking AN - 1654687775; 21155083 AB - People who inject drugs are vulnerable to infections and injuries at injection sites, but these have rarely been studied in those injecting image- and performance-enhancing drugs (IPEDs). This study examined the factors associated with reported symptoms of injection site infections and injuries in IPED injectors. Of the 366 male IPED injectors surveyed, 42% reported ever having redness, swelling and tenderness (36% in the preceding year), and 6.8% had ever had an abscess or open wound at an injection site. Having these symptoms was associated with a range of factors related to drug use and healthcare utilization. One sixth (17%) of those reporting redness, tenderness and swelling had ever sought treatment, as had the majority (76%) of those reporting an abscess, sore or open wound. Most common sources of advice were emergency clinics and General Practitioners. Interventions are needed to support access to appropriate injecting equipment and provide targeted harm reduction advice. JF - Epidemiology and Infection AU - Hope, V D AU - McVEIGH, J AU - Marongiu, A AU - Evans-Brown, M AU - Smith, J AU - KIMERGAaRD, A AU - Parry, J V AU - Ncube, F AD - Public Health England, London, UK, vivian.hope@phe.gov.uk Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 132 EP - 140 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 143 IS - 1 SN - 0950-2688, 0950-2688 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Injuries KW - Health care KW - Males KW - Risk factors KW - Intervention KW - Vulnerability KW - Risk reduction KW - Infection KW - Drug abuse KW - Drugs KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654687775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Injection+site+infections+and+injuries+in+men+who+inject+image-+and+performance-enhancing+drugs%3A+prevalence%2C+risks+factors%2C+and+healthcare+seeking&rft.au=Hope%2C+V+D%3BMcVEIGH%2C+J%3BMarongiu%2C+A%3BEvans-Brown%2C+M%3BSmith%2C+J%3BKIMERGAaRD%2C+A%3BParry%2C+J+V%3BNcube%2C+F&rft.aulast=Hope&rft.aufirst=V&rft.date=2015-01-01&rft.volume=143&rft.issue=1&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268814000727 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 36 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Health care; Injuries; Risk factors; Males; Intervention; Risk reduction; Vulnerability; Drug abuse; Infection; Drugs DO - http://dx.doi.org/10.1017/S0950268814000727 ER - TY - JOUR T1 - Age and sex differences in kidney microRNA expression during the life span of F344 rats. AN - 1652460403; 25653823 AB - Growing evidence suggests that epigenetic mechanisms of gene regulation may play a role in susceptibilities to specific toxicities and adverse drug reactions. MiRNAs in particular have been shown to be important regulators in cancer and other diseases and show promise as predictive biomarkers for diagnosis and prognosis. In this study, we characterized the global kidney miRNA expression profile in untreated male and female F344 rats throughout the life span. These findings were correlated with sex-specific susceptibilities to adverse renal events, such as male-biased renal fibrosis and inflammation in old age. Kidney miRNA expression was examined in F344 rats at 2, 5, 6, 8, 15, 21, 78, and 104 weeks of age in both sexes using Agilent miRNA microarrays. Differential expression was determined using filtering criteria of ≥1.5 fold change and ANOVA or pairwise t-test (FDR <5%) to determine significant age and sex effects, respectively. Pathway analysis software was used to investigate the possible roles of these target genes in age- and sex-specific differences. Three hundred eleven miRNAs were found to be expressed in at least one age and sex. Filtering criteria revealed 174 differentially expressed miRNAs in the kidney; 173 and 34 miRNAs exhibiting age and sex effects, respectively. Principal component analysis revealed age effects predominated over sex effects, with 2-week miRNA expression being much different from other ages. No significant sexually dimorphic miRNA expression was observed from 5 to 8 weeks, while the most differential expression (13 miRNAs) was observed at 21 weeks. Potential target genes of these differentially expressed miRNAs were identified. The expression of 56% of detected renal miRNAs was found to vary significantly with age and/or sex during the life span of F344 rats. Pathway analysis suggested that 2-week-expressed miRNAs may be related to organ and cellular development and proliferation pathways. Male-biased miRNA expression at older ages correlated with male-biased renal fibrosis and mononuclear cell infiltration. These miRNAs showed high representation in renal inflammation and nephritis pathways, and included miR-214, miR-130b, miR-150, miR-223, miR-142-5p, miR-185, and miR-296*. Analysis of kidney miRNA expression throughout the rat life span will improve the use of current and future renal biomarkers and inform our assessments of kidney injury and disease. JF - Biology of sex differences AU - Kwekel, Joshua C AU - Vijay, Vikrant AU - Desai, Varsha G AU - Moland, Carrie L AU - Fuscoe, James C AD - Division of Systems Biology, Personalized Medicine Branch, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 6 IS - 1 KW - Renal fibrosis KW - Age KW - miRNA expression KW - Kidney KW - Biomarker KW - Renal inflammation KW - Sex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652460403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+sex+differences&rft.atitle=Age+and+sex+differences+in+kidney+microRNA+expression+during+the+life+span+of+F344+rats.&rft.au=Kwekel%2C+Joshua+C%3BVijay%2C+Vikrant%3BDesai%2C+Varsha+G%3BMoland%2C+Carrie+L%3BFuscoe%2C+James+C&rft.aulast=Kwekel&rft.aufirst=Joshua&rft.date=2015-01-01&rft.volume=6&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Biology+of+sex+differences&rft.issn=&rft_id=info:doi/10.1186%2Fs13293-014-0019-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-05 N1 - Date created - 2015-02-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s13293-014-0019-1 ER - TY - JOUR T1 - Sexual dimorphism in the expression of mitochondria-related genes in rat heart at different ages. AN - 1652419542; 25615628 AB - Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Moreover, sex and age are considered major risk factors in the development of CVDs. Mitochondria are vital for normal cardiac function, and regulation of mitochondrial structure and function may impact susceptibility to CVD. To identify potential role of mitochondria in sex-related differences in susceptibility to CVD, we analyzed the basal expression levels of mitochondria-related genes in the hearts of male and female rats. Whole genome expression profiling was performed in the hearts of young (8-week), adult (21-week), and old (78-week) male and female Fischer 344 rats and the expression of 670 unique genes related to various mitochondrial functions was analyzed. A significant (p<0.05) sexual dimorphism in expression levels of 46, 114, and 41 genes was observed in young, adult and old rats, respectively. Gene Ontology analysis revealed the influence of sex on various biological pathways related to cardiac energy metabolism at different ages. The expression of genes involved in fatty acid metabolism was significantly different between the sexes in young and adult rat hearts. Adult male rats also showed higher expression of genes associated with the pyruvate dehydrogenase complex compared to females. In young and adult hearts, sexual dimorphism was not noted in genes encoding oxidative phosphorylation. In old rats, however, a majority of genes involved in oxidative phosphorylation had higher expression in females compared to males. Such basal differences between the sexes in cardiac expression of genes associated with energy metabolism may indicate a likely involvement of mitochondria in susceptibility to CVDs. In addition, female rats showed lower expression levels of apoptotic genes in hearts compared to males at all ages, which may have implications for better preservation of cardiac mass in females than in males. JF - PloS one AU - Vijay, Vikrant AU - Han, Tao AU - Moland, Carrie L AU - Kwekel, Joshua C AU - Fuscoe, James C AU - Desai, Varsha G AD - Personalized Medicine Branch, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 1 KW - Mitochondrial Proteins KW - 0 KW - Index Medicus KW - Rats KW - Gene Expression Profiling KW - Animals KW - Rats, Inbred F344 KW - Cardiovascular Diseases -- etiology KW - Sex Characteristics KW - Genome, Mitochondrial KW - Gene Expression Regulation KW - Male KW - Female KW - Mitochondrial Proteins -- genetics KW - Mitochondria, Heart -- genetics KW - Energy Metabolism KW - Heart -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652419542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Sexual+dimorphism+in+the+expression+of+mitochondria-related+genes+in+rat+heart+at+different+ages.&rft.au=Vijay%2C+Vikrant%3BHan%2C+Tao%3BMoland%2C+Carrie+L%3BKwekel%2C+Joshua+C%3BFuscoe%2C+James+C%3BDesai%2C+Varsha+G&rft.aulast=Vijay&rft.aufirst=Vikrant&rft.date=2015-01-01&rft.volume=10&rft.issue=1&rft.spage=e0117047&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0117047 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-04 N1 - Date created - 2015-01-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mol Med. 2011 May-Jun;17(5-6):542-9 [21193900] Congest Heart Fail. 2011 Nov-Dec;17(6):255-6 [22103916] Gynecol Endocrinol. 2012 Sep;28(9):746-51 [22329808] Handb Exp Pharmacol. 2012;(214):23-48 [23027444] Gen Physiol Biophys. 2013 Sep;32(3):415-20 [23817642] Am Heart J. 2000 Feb;139(2 Pt 3):S70-85 [10650320] Mol Cell Biol. 2000 Apr;20(8):2890-901 [10733592] Mol Cell Biochem. 2000 Dec;215(1-2):21-30 [11204452] Adv Enzyme Regul. 2001;41:269-88 [11384751] Circ Res. 1991 Jun;68(6):1560-8 [2036710] Physiol Rev. 1992 Oct;72(4):881-940 [1438581] J Pediatr. 1994 Feb;124(2):224-8 [8301427] Exp Cell Res. 1995 Jul;219(1):110-21 [7628527] J Am Coll Cardiol. 1995 Oct;26(4):1068-79 [7560601] Am Heart J. 1996 Apr;131(4):704-9 [8721642] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9782-7 [8790408] N Engl J Med. 1997 Apr 17;336(16):1131-41 [9099657] Nat Genet. 1997 Jul;16(3):226-34 [9207786] Biochem Cell Biol. 1997;75(2):137-42 [9250361] Circulation. 1997 Oct 7;96(7):2468-82 [9337227] J Am Coll Cardiol. 1997 Dec;30(7):1872-7 [9385921] Science. 1999 Mar 5;283(5407):1482-8 [10066162] Semin Perinatol. 1999 Apr;23(2):125-51 [10331465] J Mol Cell Cardiol. 2004 Nov;37(5):921-9 [15522269] J Clin Invest. 2005 Mar;115(3):547-55 [15765136] Free Radic Biol Med. 2005 May 15;38(10):1278-95 [15855047] Science. 2005 Jun 10;308(5728):1583-7 [15947175] Can J Physiol Pharmacol. 2006 Jan;84(1):93-109 [16845894] Exp Gerontol. 2007 Mar;42(3):173-82 [17118599] Comp Biochem Physiol A Mol Integr Physiol. 2007 Jan;146(1):26-39 [17081788] Ann Med. 2007;39(1):28-41 [17364449] Cardiovasc Res. 2007 Jun 1;74(3):456-65 [17376413] Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):224-36 [17442631] BMC Bioinformatics. 2008;9 Suppl 9:S20 [18793466] J Clin Invest. 1988 Dec;82(6):2017-25 [3198763] N Engl J Med. 1990 May 31;322(22):1561-6 [2139921] Eur Heart J. 1990 Jun;11(6):509-16 [2161769] Womens Health (Lond Engl). 2010 Sep;6(5):737-52 [20887171] Pediatr Res. 1990 Dec;28(6):657-62 [2284166] J Cell Biochem. 2008 Dec 15;105(6):1342-51 [18846505] Mitochondrion. 2009 Feb;9(1):9-16 [18824140] Mitochondrion. 2009 Apr;9(2):149-58 [19460291] Toxicol Appl Pharmacol. 2009 Jul 15;238(2):150-9 [19442681] Annu Rev Physiol. 2009;71:1-18 [18828746] Methods Mol Biol. 2009;563:379-98 [19597796] Exp Biol Med (Maywood). 2009 Sep;234(9):1011-9 [19546346] BMC Bioinformatics. 2006;7 Suppl 2:S11 [17118132] Circ J. 2010 Jul;74(7):1265-73 [20558892] Nat Rev Mol Cell Biol. 2010 Sep;11(9):655-67 [20729931] Nat Commun. 2014;5:3230 [24510058] Philos Trans R Soc Lond B Biol Sci. 2014 Jul 5;369(1646):20130446 [24864314] J Clin Invest. 2001 Jun;107(11):1403-9 [11390422] J Mol Cell Cardiol. 2001 Jun;33(6):1065-89 [11444914] Methods. 2001 Dec;25(4):402-8 [11846609] Heart Fail Rev. 2002 Apr;7(2):115-30 [11988636] Ann N Y Acad Sci. 2004 Apr;1011:86-100 [15126287] Cardiovasc Res. 2004 Aug 15;63(3):510-9 [15276476] J Mol Cell Cardiol. 2004 Aug;37(2):507-13 [15276020] Biochem Soc Trans. 2004 Dec;32(Pt 6):1021-4 [15506953] J Natl Cancer Inst. 1975 Jun;54(6):1449-56 [1133852] Biochem J. 1980 Nov 1;191(2):421-7 [6263247] BMC Genomics. 2010;11:675 [21118493] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0117047 ER - TY - JOUR T1 - The relationship between elemental carbon and diesel particulate matter in underground metal/nonmetal mines in the United States and coal mines in Australia. AN - 1652396689; 25380085 AB - In the United States, total carbon (TC) is used as a surrogate for determining diesel particulate matter (DPM) compliance exposures in underground metal/nonmetal mines. Since TC can be affected by interferences and elemental carbon (EC) is not, one method used to estimate the TC concentration is to multiply the EC concentration from the personal sample by a conversion factor to avoid the influence of potential interferences. Since there is no accepted single conversion factor for all metal/nonmetal mines, one is determined every time an exposure sample is taken by collecting an area sample that represents the TC/EC ratio in the miner's breathing zone and is away from potential interferences. As an alternative to this procedure, this article investigates the relationship between TC and EC from DPM samples to determine if a single conversion factor can be used for all metal/nonmetal mines. In addition, this article also investigates how well EC represents DPM concentrations in Australian coal mines since the recommended exposure limit for DPM in Australia is an EC value. When TC was predicted from EC values using a single conversion factor of 1.27 in 14 US metal/nonmetal mines, 95% of the predicted values were within 18% of the measured value, even at the permissible exposure limit (PEL) concentration of 160 μg/m(3) TC. A strong correlation between TC and EC was also found in nine underground coal mines in Australia. JF - Journal of occupational and environmental hygiene AU - Noll, James AU - Gilles, Stewart AU - Wu, Hsin Wei AU - Rubinstein, Elaine AD - a Dust, Ventilation and Toxic Substance Branch, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health , Pittsburgh Research Laboratory , Pittsburgh , Pennsylvania. Y1 - 2015 PY - 2015 DA - 2015 SP - 205 EP - 211 VL - 12 IS - 3 KW - Air Pollutants, Occupational KW - 0 KW - Particulate Matter KW - Vehicle Emissions KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - diesel KW - elemental carbon KW - measurement KW - United States KW - Australia KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- methods KW - Air Pollutants, Occupational -- analysis KW - Mining KW - Carbon -- analysis KW - Particulate Matter -- analysis KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652396689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=The+relationship+between+elemental+carbon+and+diesel+particulate+matter+in+underground+metal%2Fnonmetal+mines+in+the+United+States+and+coal+mines+in+Australia.&rft.au=Noll%2C+James%3BGilles%2C+Stewart%3BWu%2C+Hsin+Wei%3BRubinstein%2C+Elaine&rft.aulast=Noll&rft.aufirst=James&rft.date=2015-01-01&rft.volume=12&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2014.960577 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-19 N1 - Date created - 2015-01-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Environ Monit. 2004 Oct;6(10):799-806 [15480493] Analyst. 1996 Sep;121(9):1183-90 [8831275] Environ Sci Technol. 2008 Jul 15;42(14):5223-8 [18756633] J Occup Environ Hyg. 2005 Jan;2(1):29-37 [15764521] Environ Sci Technol. 2007 Feb 1;41(3):710-6 [17333567] J Environ Monit. 2004 Dec;6(12):973-8 [15568046] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2014.960577 ER - TY - JOUR T1 - Non-smoker exposure to secondhand cannabis smoke. I. Urine screening and confirmation results. AN - 1652376881; 25326203 AB - Increased cannabis potency has renewed concerns that secondhand exposure to cannabis smoke can produce positive drug tests. A systematic study was conducted of smoke exposure on drug-free participants. Six experienced cannabis users smoked cannabis cigarettes (5.3% THC in Session 1 and 11.3% THC in Sessions 2 and 3) in a sealed chamber. Six non-smokers were seated with smokers in an alternating manner. Sessions 1 and 2 were conducted with no ventilation and ventilation was employed in Session 3. Non-smoking participant specimens (collected 0-34 h) were analyzed with four immunoassays at different cutoff concentrations (20, 50, 75 and 100 ng/mL) and by GC-MS (LOQ = 0.75 ng/mL). No presumptive positives occurred for non-smokers at 100 and 75 ng/mL; a single positive occurred at 50 ng/mL; and multiple positives occurred at 20 ng/mL. Maximum THCCOOH concentrations by GC-MS for non-smokers ranged from 1.3 to 57.5 ng/mL. THCCOOH concentrations generally increased with THC potency, but room ventilation substantially reduced exposure levels. These results demonstrate that extreme cannabis smoke exposure can produce positive urine tests at commonly utilized cutoff concentrations. However, positive tests are likely to be rare, limited to the hours immediately post-exposure, and occur only under environmental circumstances where exposure is obvious. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Journal of analytical toxicology AU - Cone, Edward J AU - Bigelow, George E AU - Herrmann, Evan S AU - Mitchell, John M AU - LoDico, Charles AU - Flegel, Ronald AU - Vandrey, Ryan AD - Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA edwardjcone@gmail.com. ; Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; RTI International, Research Triangle Park, NC, USA. ; Division of Workplace Programs (DWP), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD, USA. PY - 2015 SP - 1 EP - 12 VL - 39 IS - 1 KW - Tobacco Smoke Pollution KW - 0 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Sensitivity and Specificity KW - Young Adult KW - Humans KW - Adult KW - Specimen Handling KW - Gas Chromatography-Mass Spectrometry KW - Urinalysis KW - Male KW - Female KW - Dronabinol -- urine KW - Cannabis -- chemistry KW - Tobacco Smoke Pollution -- adverse effects KW - Smoking -- adverse effects KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652376881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Non-smoker+exposure+to+secondhand+cannabis+smoke.+I.+Urine+screening+and+confirmation+results.&rft.au=Cone%2C+Edward+J%3BBigelow%2C+George+E%3BHerrmann%2C+Evan+S%3BMitchell%2C+John+M%3BLoDico%2C+Charles%3BFlegel%2C+Ronald%3BVandrey%2C+Ryan&rft.aulast=Cone&rft.aufirst=Edward&rft.date=2015-01-01&rft.volume=39&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbku116 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-06 N1 - Date created - 2015-01-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Forensic Sci. 2000 Jan;45(1):24-30 [10641915] PLoS One. 2013;8(7):e70052 [23894589] Clin Pharmacol Ther. 1983 Jul;34(1):36-41 [6305545] J Anal Toxicol. 1983 Jul-Aug;7(4):172-4 [6314043] J Pharm Pharmacol. 1984 May;36(5):289-94 [6145762] J Pharm Pharmacol. 1984 Sep;36(9):578-81 [6149279] J Forensic Sci. 1985 Oct;30(4):997-1002 [2999292] Clin Pharmacol Ther. 1986 Sep;40(3):247-56 [3017628] Arch Kriminol. 1987 Jan-Feb;179(1-2):31-7 [3551865] J Anal Toxicol. 1987 May-Jun;11(3):89-96 [3037193] J Anal Toxicol. 1988 May-Jun;12(3):113-6 [3386204] Forensic Sci Int. 2008 Jan 30;174(2-3):111-9 [17434274] J Anal Toxicol. 2005 Oct;29(7):607-15 [16419389] J Anal Toxicol. 1992 Jul-Aug;16(4):228-35 [1323733] Br J Psychiatry. 2009 Dec;195(6):488-91 [19949195] J Anal Toxicol. 2010 May;34(4):196-203 [20465865] Neuropsychopharmacology. 2010 Aug;35(9):1879-85 [20428110] Dtsch Arztebl Int. 2012 Jul;109(29-30):495-501 [23008748] Curr Pharm Des. 2012;18(32):5113-30 [22716133] Clin Pharmacokinet. 2003;42(4):327-60 [12648025] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jat/bku116 ER - TY - JOUR T1 - Participant and site characteristics related to participant retention in a diabetes prevention translational project AN - 1648072807; 4638778 AB - Using multilevel analysis, this study investigated participant and site characteristics associated with participant retention in a multisite diabetes prevention translational project among American Indian and Alaska Native (AI/AN) people. We analyzed data from the Special Diabetes Program for Indians Diabetes Prevention Program (SDPI-DP), a lifestyle intervention to prevent diabetes implemented in 36 AI/AN grantee sites. A total of 2,553 participants were recruited and started the intervention between January 1, 2006 and July 31, 2008. They were offered the 16-session Italic Lifestyle Balance Curriculum from the Diabetes Prevention Program (DPP) in the first 16-24_weeks of intervention. Generalized estimating equation models and proportional hazards models with robust standard error estimates were used to evaluate the relationships of participant and site characteristics with retention. As of July 31, 2009, about 50_% of SDPI-DP participants were lost to follow-up. Those who were younger, male, with lower household income, no family support person, and more baseline chronic pain were at higher risk for both short-term and long-term retention failure (i.e., not completing all 16 DPP sessions and loss to follow-up, respectively). Sites with large user populations and younger staff had lower likelihood of retaining participants successfully. Other site characteristics related to higher risk for retention failure included staff rating of participant disinterest in SDPI-DP and barriers to participant transportation and child/elder care. Future translational initiatives need to pay attention to both participant- and site-level factors in order to maximize participant retention. Reprinted by permission of Springer JF - Prevention science AU - Jiang, Luohua AU - Manson, Spero M AU - Dill, Edward J AU - Beals, Janette AU - Johnson, Ann AU - Huang, Haixiao AU - Acton, Kelly J AU - Roubideaux, Yvette AD - Texas A&M University ; University of Colorado ; US Department of Health and Human Services Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 41 EP - 52 VL - 16 IS - 1 SN - 1389-4986, 1389-4986 KW - Sociology KW - Indians KW - Prevention KW - U.S.A. KW - Life styles KW - Risk theory KW - Public health KW - Dropouts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1648072807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prevention+science&rft.atitle=Participant+and+site+characteristics+related+to+participant+retention+in+a+diabetes+prevention+translational+project&rft.au=Jiang%2C+Luohua%3BManson%2C+Spero+M%3BDill%2C+Edward+J%3BBeals%2C+Janette%3BJohnson%2C+Ann%3BHuang%2C+Haixiao%3BActon%2C+Kelly+J%3BRoubideaux%2C+Yvette&rft.aulast=Jiang&rft.aufirst=Luohua&rft.date=2015-01-01&rft.volume=16&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Prevention+science&rft.issn=13894986&rft_id=info:doi/10.1007%2Fs11121-013-0451-1 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-01-26 N1 - Last updated - 2015-01-26 N1 - SubjectsTermNotLitGenreText - 3739 7684; 10072; 6301 1335 4424; 10449 5772; 7404; 11040 11035; 433 293 14 DO - http://dx.doi.org/10.1007/s11121-013-0451-1 ER - TY - JOUR T1 - Real-time PCR detection of Listeria monocytogenes in infant formula and lettuce following macrophage-based isolation and enrichment AN - 1647021295; 21232041 AB - To develop a rapid detection procedure for Listeria monocytogenes in infant formula and lettuce using a macrophage-based enrichment protocol and real-time PCR. A macrophage cell culture system was employed for the isolation and enrichment of L. monocytogenes from infant formula and lettuce for subsequent identification using real-time PCR. Macrophage monolayers were exposed to infant formula and lettuce contaminated with a serial dilution series of L. monocytogenes. As few as approx. 10 CFU ml-1 or g-1 of L. monocytogenes were detected in infant formula and lettuce after 16 h postinfection by real-time PCR. Internal positive PCR controls were utilized to eliminate the possibility of false-negative results. Co-inoculation with Listeria innocua did not reduce the L. monocytogenes detection sensitivity. Intracellular L. monocytogenes could also be isolated on Listeria selective media from infected macrophage lysates for subsequent confirmation. The detection method is highly sensitive and specific for L. monocytogenes in infant formula and lettuce and establishes a rapid identification time of 20 and 48 h for presumptive and confirmatory identification, respectively. The method is a promising alternative to many currently used q-PCR detection methods which employ traditional selective media for enrichment of contaminated food samples. Macrophage enrichment of L. monocytogenes eliminates PCR inhibitory food elements and contaminating food microflora which produce cleaner samples that increase the rapidity and sensitivity of detection. JF - Journal of Applied Microbiology AU - Day, J B AU - Basavanna, U AD - U.S. Food and Drug Administration. Center for Food Safety and Applied Nutrition Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 233 EP - 244 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 118 IS - 1 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Macrophages KW - Listeria monocytogenes KW - Infant formulas KW - Colony-forming cells KW - Listeria innocua KW - Microflora KW - Polymerase chain reaction KW - Cell culture KW - Food contamination KW - Media (selective) KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647021295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Real-time+PCR+detection+of+Listeria+monocytogenes+in+infant+formula+and+lettuce+following+macrophage-based+isolation+and+enrichment&rft.au=Day%2C+J+B%3BBasavanna%2C+U&rft.aulast=Day&rft.aufirst=J&rft.date=2015-01-01&rft.volume=118&rft.issue=1&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.12674 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Infant formulas; Colony-forming cells; Microflora; Polymerase chain reaction; Cell culture; Food contamination; Media (selective); Listeria monocytogenes; Listeria innocua DO - http://dx.doi.org/10.1111/jam.12674 ER - TY - JOUR T1 - The impact of introduced hosts on parasite transmission: opisthorchiid infections in American mink (Neovison vison) AN - 1647008727; 21314312 AB - Introduced animals may be considered at an advantage over native competitors because they have escaped natural parasites. In some cases however, generalist parasites in a novel environment can use introduced species as an alternative or reservoir host. This can change the dynamics of parasite populations, with implications for epidemiology. The key factor determining the impact of an alternative host is its ability to maintain a reproductively successful parasite and contribute to the transmission potential of that parasite. The digenean Pseudamphistomum truncatum is found in native otters Lutra lutra in Britain and has been reported in introduced American mink Neovison vison. To investigate whether introduced mink are competent hosts and to ask how mink compare with otters as hosts, we compared parasite prevalence, intensity and fecundity between the two host species in a region where both are common. Although prevalence was not statistically different between otters and mink (48 %, n = 27, compared to 33 %, n = 21 respectively), mean parasite intensity was higher in mink (253 plus or minus 145 standard error parasites/infected host, compared to 46 plus or minus 18 in otters). Parasite fecundity was lower in mink (mean egg count/parasite/host = 622 plus or minus 64) than in otters (1,204 plus or minus 108), and this difference was not confounded by host or parasite size or by intraspecific competition among parasites. Assuming the parasite eggs are equally viable from otters or mink, mink are not only a competent host for P. truncatum, but because of the higher parasite intensity in mink, they can potentially spread c.3 times as many parasite eggs to intermediate hosts, than otters. The naturalisation of mink to new habitats may therefore contribute to trematode infections in native fauna. JF - Biological Invasions AU - Sherrard-Smith, Ellie AU - Chadwick, Elizabeth A AU - Cable, Jo AD - School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK, ellie.sherrard-smith@phe.gov.uk PY - 2015 SP - 115 EP - 122 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 1 SN - 1387-3547, 1387-3547 KW - Sustainability Science Abstracts; Ecology Abstracts KW - Introduced animals KW - Parasites KW - Mammals KW - Infection KW - Eggs KW - Disease transmission KW - Fauna KW - Invasions KW - Reservoirs KW - Competition KW - Pseudamphistomum truncatum KW - Habitat KW - Fecundity KW - Epidemiology KW - Lutrinae KW - Introduced species KW - Lutra lutra KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647008727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Invasions&rft.atitle=The+impact+of+introduced+hosts+on+parasite+transmission%3A+opisthorchiid+infections+in+American+mink+%28Neovison+vison%29&rft.au=Sherrard-Smith%2C+Ellie%3BChadwick%2C+Elizabeth+A%3BCable%2C+Jo&rft.aulast=Sherrard-Smith&rft.aufirst=Ellie&rft.date=2015-01-01&rft.volume=17&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Biological+Invasions&rft.issn=13873547&rft_id=info:doi/10.1007%2Fs10530-014-0709-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Number of references - 57 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Parasites; Fecundity; Epidemiology; Invasions; Habitat; Introduced species; Infection; Competition; Eggs; Disease transmission; Introduced animals; Fauna; Mammals; Reservoirs; Pseudamphistomum truncatum; Lutrinae; Lutra lutra DO - http://dx.doi.org/10.1007/s10530-014-0709-y ER - TY - JOUR T1 - Effects of perinatal methylphenidate (MPH) treatment on postweaning behaviors of male and female Sprague-Dawley rats. AN - 1645234020; 25514582 AB - Methylphenidate (MPH) is a common treatment for adult Attention Deficit Hyperactivity Disorder (ADHD). However, little information exists regarding its safety during pregnancy and thus, women with ADHD face difficult decisions regarding continued use during pregnancy. Thus, Sprague-Dawley rats were orally treated 3×/day with 0 (control), 6 (low), 18 (mid), or 42 (high) mg MPH/kg/day (i.e., 0, 2, 6, or 14mg/kg at each treatment time) on gestational days 6-21. All offspring/litter were orally treated with the same dose their dam had received on postnatal days (PNDs) 1-21. After weaning, offspring were assessed for adolescent play behavior, locomotor activity, motor coordination, Barnes maze performance, acoustic startle response, novel object recognition, residential running wheel activity, flavored solution intake, home cage behavior, water maze performance, elevated plus maze behavior, locomotor response to an MPH challenge, and passive avoidance. At euthanasia, whole brain and striatal weights as well as serum hormone levels were measured. Body weights of the high MPH group were reduced in both sexes. Males of the high MPH group were less active than control males in open field assessments on PNDs 40-42. Latency to maximum acoustic startle was significantly altered in females of the medium and high MPH groups and residential running wheel activity of females of the low and medium MPH groups was lower than control females. Open arm entries in the elevated plus maze were increased in subjects of the medium MPH group. Females of the low MPH group were less sensitive to the locomotor-increasing effects of an acute 5mg/kg MPH challenge. Serum hormone levels and whole brain and striatal weights were not altered by prior MPH treatment. These results indicate that MPH treatment during development has sporadic effects on postweaning behaviors and those effects were generally exhibited by females. Published by Elsevier Inc. JF - Neurotoxicology and teratology AU - Ferguson, Sherry A AU - Delbert Law, C AU - Sahin, Leyla AU - Montenegro, Susan V AD - Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: Sherry.Ferguson@fda.hhs.gov. ; Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, United States. ; Pediatric and Maternal Health Staff, Office of New Drugs, Center for Drug Evaluation Research, Food and Drug Administration, Silver Spring, MD 20993, United States. ; Division of Epidemiology II, Office of Pharmacovigilance and Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation Research, Food and Drug Administration, Silver Spring, MD 20993, United States. PY - 2015 SP - 125 EP - 136 VL - 47 KW - Central Nervous System Stimulants KW - 0 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Index Medicus KW - Rat KW - Hormone KW - Behavior KW - Ritalinic acid KW - Pregnancy KW - Eating -- drug effects KW - Animals KW - Maze Learning -- drug effects KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Brain -- drug effects KW - Homing Behavior -- drug effects KW - Sensory Gating -- drug effects KW - Avoidance Learning -- drug effects KW - Rats KW - Animals, Newborn KW - Rats, Sprague-Dawley KW - Psychomotor Performance -- drug effects KW - Drinking -- drug effects KW - Exploratory Behavior -- drug effects KW - Body Weight -- drug effects KW - Motor Activity -- drug effects KW - Male KW - Female KW - Behavior, Animal -- drug effects KW - Central Nervous System Stimulants -- toxicity KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Methylphenidate -- toxicity KW - Prenatal Exposure Delayed Effects -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645234020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Effects+of+perinatal+methylphenidate+%28MPH%29+treatment+on+postweaning+behaviors+of+male+and+female+Sprague-Dawley+rats.&rft.au=Ferguson%2C+Sherry+A%3BDelbert+Law%2C+C%3BSahin%2C+Leyla%3BMontenegro%2C+Susan+V&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2015-01-01&rft.volume=47&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=1872-9738&rft_id=info:doi/10.1016%2Fj.ntt.2014.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-10 N1 - Date created - 2015-01-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ntt.2014.12.002 ER - TY - JOUR T1 - Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. AN - 1643406948; 25302578 AB - Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and druglike molecules impact mitochondrial function represents an initial step in predicting exposure-related toxicity and defining a possible role for such compounds in the onset of various diseases. We sought to identify individual chemicals and general structural features associated with changes in mitochondrial membrane potential (MMP). We used a multiplexed [two end points in one screen; MMP and adenosine triphosphate (ATP) content] quantitative high throughput screening (qHTS) approach combined with informatics tools to screen the Tox21 library of 10,000 compounds (~ 8,300 unique chemicals) at 15 concentrations each in triplicate to identify chemicals and structural features that are associated with changes in MMP in HepG2 cells. Approximately 11% of the compounds (913 unique compounds) decreased MMP after 1 hr of treatment without affecting cell viability (ATP content). In addition, 309 compounds decreased MMP over a concentration range that also produced measurable cytotoxicity [half maximal inhibitory concentration (IC50) in MMP assay/IC50 in viability assay ≤ 3; p < 0.05]. More than 11% of the structural clusters that constitute the Tox21 library (76 of 651 clusters) were significantly enriched for compounds that decreased the MMP. Our multiplexed qHTS approach allowed us to generate a robust and reliable data set to evaluate the ability of thousands of drugs and environmental compounds to decrease MMP. The use of structure-based clustering analysis allowed us to identify molecular features that are likely responsible for the observed activity. JF - Environmental health perspectives AU - Attene-Ramos, Matias S AU - Huang, Ruili AU - Michael, Sam AU - Witt, Kristine L AU - Richard, Ann AU - Tice, Raymond R AU - Simeonov, Anton AU - Austin, Christopher P AU - Xia, Menghang AD - National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 49 EP - 56 VL - 123 IS - 1 KW - Environmental Pollutants KW - 0 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Hep G2 Cells KW - Dose-Response Relationship, Drug KW - Humans KW - Toxicity Tests KW - Adenosine Triphosphate -- analysis KW - Cell Survival KW - High-Throughput Screening Assays KW - Membrane Potential, Mitochondrial -- drug effects KW - Environmental Pollutants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1643406948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Profiling+of+the+Tox21+chemical+collection+for+mitochondrial+function+to+identify+compounds+that+acutely+decrease+mitochondrial+membrane+potential.&rft.au=Attene-Ramos%2C+Matias+S%3BHuang%2C+Ruili%3BMichael%2C+Sam%3BWitt%2C+Kristine+L%3BRichard%2C+Ann%3BTice%2C+Raymond+R%3BSimeonov%2C+Anton%3BAustin%2C+Christopher+P%3BXia%2C+Menghang&rft.aulast=Attene-Ramos&rft.aufirst=Matias&rft.date=2015-01-01&rft.volume=123&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408642 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-22 N1 - Date created - 2015-01-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7 [19076321] Exp Mol Pathol. 2007 Aug;83(1):84-92 [17239370] J Mol Cell Cardiol. 2010 Nov;49(5):728-36 [20620145] Drug Discov Today. 2010 Dec;15(23-24):997-1007 [20708096] Curr Drug Targets. 2011 Jun;12(6):774-82 [21275886] Environ Health Perspect. 2011 Aug;119(8):1142-8 [21543282] Adv Exp Med Biol. 2012;942:385-419 [22399433] Physiol Genomics. 2012 May 1;44(9):495-503 [22433785] Toxicol Sci. 2013 Jan;131(1):271-8 [22977170] Toxicol In Vitro. 2013 Mar;27(2):978-90 [23232461] Environ Health Perspect. 2013 Jul;121(7):756-65 [23603828] Drug Discov Today. 2013 Aug;18(15-16):716-23 [23732176] Chem Res Toxicol. 2013 Sep 16;26(9):1323-32 [23895456] Chem Res Toxicol. 2008 Apr;21(4):911-27 [18358007] Biol Chem. 1999 Oct;380(10):1157-66 [10595578] Eur J Cancer. 1999 Oct;35(10):1517-25 [10673981] J Bioenerg Biomembr. 1999 Dec;31(6):581-90 [10682916] Int J Radiat Biol. 2000 Oct;76(10):1323-33 [11057740] Biochem J. 2001 Jun 1;356(Pt 2):621-6 [11368793] J Mol Cell Cardiol. 2001 Jun;33(6):1065-89 [11444914] EMBO J. 2001 Aug 1;20(15):4107-21 [11483514] Toxicol Sci. 2002 Sep;69(1):131-8 [12215667] Antioxid Redox Signal. 2002 Oct;4(5):769-81 [12470504] Mol Pharmacol. 2003 Jan;63(1):232-42 [12488556] Biochem J. 1964 May;91(2):287-97 [4220923] J Biol Chem. 1973 Jan 25;248(2):610-8 [4684694] Mol Cell Biochem. 1982 May 28;45(1):13-31 [7050653] FEBS Lett. 1986 Jun 9;201(2):267-70 [3086126] Chem Biol Interact. 1987;62(2):179-89 [3594640] J Immunol Methods. 1993 Mar 15;160(1):81-8 [7680699] Microsc Res Tech. 1994 Feb 15;27(3):198-219 [8204911] Biochem Pharmacol. 1998 Jun 1;55(11):1907-14 [9714309] Biochim Biophys Acta. 1998 Aug 10;1366(1-2):53-67 [9714734] Leukemia. 1999 Aug;13(8):1273-80 [10450757] Nature. 1953 Jan 3;171(4340):30-2 [13025467] Nature. 1961 Jul 8;191:144-8 [13771349] J Biochem. 1964 Aug;56:151-6 [14228485] Curr Biol. 2006 Jul 25;16(14):R551-60 [16860735] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Neural Netw. 2006 Jul-Aug;19(6-7):723-33 [16774731] Comment In: Environ Health Perspect. 2015 Jan;123(1):A23 [25561610] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408642 ER - TY - JOUR T1 - Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. AN - 1643406894; 25136773 AB - The link between environmental estrogen exposure and defects in the female reproductive tract is well established. The phytoestrogen genistein is able to modulate uterine estrogen receptor (ER) activity, and dietary exposure is associated with uterine pathologies. Regulation of stress and immune functions by the glucocorticoid receptor (GR) is also an integral part of maintaining reproductive tract function; disruption of GR signaling by genistein may also have a role in the adverse effects of genistein. We evaluated the transcriptional response to genistein in Ishikawa cells and investigated the effects of genistein on GR-mediated target genes. We used Ishikawa cells as a model system to identify novel targets of genistein and the synthetic glucocorticoid dexamethasone through whole genome microarray analysis. Common gene targets were defined and response patterns verified by quantitative real-time reverse-transcription polymerase chain reaction. The mechanism of transcriptional antagonism was determined for select genes. Genistein regulated numerous genes in Ishikawa cells independently of estradiol, and the response to coadministration of genistein and dexamethasone was unique compared with the response to either estradiol or dexamethasone alone. Furthermore, genistein altered glucocorticoid regulation of GR target genes. In a select set of genes, co-regulation by dexamethasone and genistein was found to require both GR and ERα signaling, respectively. Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome. JF - Environmental health perspectives AU - Whirledge, Shannon AU - Senbanjo, Linda T AU - Cidlowski, John A AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 80 EP - 87 VL - 123 IS - 1 KW - Estrogen Receptor alpha KW - 0 KW - Phytoestrogens KW - Receptors, Glucocorticoid KW - estrogen receptor alpha, human KW - Estradiol KW - 4TI98Z838E KW - Dexamethasone KW - 7S5I7G3JQL KW - Genistein KW - DH2M523P0H KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Humans KW - Signal Transduction -- drug effects KW - Estradiol -- pharmacology KW - Microarray Analysis KW - Estrogen Receptor alpha -- drug effects KW - Cell Line, Tumor KW - Uterus -- drug effects KW - Female KW - Gene Expression -- drug effects KW - Receptors, Glucocorticoid -- drug effects KW - Genistein -- pharmacology KW - Phytoestrogens -- pharmacology KW - Gene Expression Regulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1643406894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Genistein+disrupts+glucocorticoid+receptor+signaling+in+human+uterine+endometrial+Ishikawa+cells.&rft.au=Whirledge%2C+Shannon%3BSenbanjo%2C+Linda+T%3BCidlowski%2C+John+A&rft.aulast=Whirledge&rft.aufirst=Shannon&rft.date=2015-01-01&rft.volume=123&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408437 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-22 N1 - Date created - 2015-01-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mol Hum Reprod. 2000 Jan;6(1):68-74 [10611263] Biol Reprod. 2013 Sep;89(3):66 [23843231] Am J Pathol. 2001 Mar;158(3):905-19 [11238039] J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):129-38 [12270206] Toxicology. 2002 Dec 27;181-182:371-82 [12505339] Proc Natl Acad Sci U S A. 1970 Mar;65(3):709-15 [4315614] J Biol Chem. 1987 Apr 25;262(12):5592-5 [3106339] Gastroenterology. 1987 Aug;93(2):225-33 [3297906] Mol Endocrinol. 1990 Oct;4(10):1427-37 [1704480] Epidemiol Rev. 1990;12:1-15 [2286214] J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):331-7 [1314077] Acta Physiol Hung. 1994;82(3):195-200 [7717082] J Clin Invest. 1997 May 15;99(10):2342-50 [9153275] Reprod Biol Endocrinol. 2004 Oct 17;2:73 [15488153] Structure. 2004 Dec;12(12):2197-207 [15576033] Adv Exp Med Biol. 2004;546:121-65 [15584372] Environ Health Perspect. 2006 Jun;114(6):A352-8 [16759972] FASEB J. 2007 Feb;21(2):402-14 [17185747] Hum Reprod Update. 2008 Jan-Feb;14(1):59-72 [18070835] Nucleic Acids Res. 2008 Jan;36(Database issue):D102-6 [18006571] Mol Endocrinol. 2008 May;22(5):1032-43 [18258689] FASEB J. 2009 Nov;23(11):3649-58 [19567371] Aust Vet J. 1946 Feb;22:2-12 [21028682] Ann N Y Acad Sci. 2011 Mar;1221:98-102 [21401636] PLoS One. 2011;6(3):e18242 [21483825] Am J Reprod Immunol. 2011 Jul;66 Suppl 1:88-92 [21726343] Horm Metab Res. 2012 Jul;44(8):587-91 [22438212] Immunol Res. 2012 Dec;54(1-3):95-110 [22484990] PLoS One. 2012;7(10):e47979 [23110148] Genome Res. 2012 Nov;22(11):2153-62 [23019147] Endocrinology. 2013 Jan;154(1):499-510 [23183181] Trends Endocrinol Metab. 2013 Mar;24(3):109-19 [23312823] Cancer Res. 2013 Aug 15;73(16):5130-9 [23803465] Biofactors. 2000;12(1-4):209-15 [11216488] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408437 ER - TY - JOUR T1 - Perfluorochemicals and human semen quality: the LIFE study. AN - 1643406797; 25127343 AB - The relation between persistent environmental chemicals and semen quality is evolving, although limited data exist for men recruited from general populations. We examined the relation between perfluorinated chemicals (PFCs) and semen quality among 501 male partners of couples planning pregnancy. Using population-based sampling strategies, we recruited 501 couples discontinuing contraception from two U.S. geographic regions from 2005 through 2009. Baseline interviews and anthropometric assessments were conducted, followed by blood collection for the quantification of seven serum PFCs (perfluorosulfonates, perfluorocarboxylates, and perfluorosulfonamides) using tandem mass spectrometry. Men collected a baseline semen sample and another approximately 1 month later. Semen samples were shipped with freezer packs, and analyses were performed on the day after collection. We used linear regression to estimate the difference in each semen parameter associated with a one unit increase in the natural log-transformed PFC concentration after adjusting for confounders and modeling repeated semen samples. Sensitivity analyses included optimal Box-Cox transformation of semen quality end points. Six PFCs [2-(N-methyl-perfluorooctane sulfonamido) acetate (Me-PFOSA-AcOH), perfluorodecanoate (PFDeA), perfluorononanoate (PFNA), perfluorooctane sulfonamide (PFOSA), perfluorooctane sulfonate (PFOS), and perfluorooctanoic acid (PFOA)] were associated with 17 semen quality end points before Box-Cox transformation. PFOSA was associated with smaller sperm head area and perimeter, a lower percentage of DNA stainability, and a higher percentage of bicephalic and immature sperm. PFDeA, PFNA, PFOA, and PFOS were associated with a lower percentage of sperm with coiled tails. Select PFCs were associated with certain semen end points, with the most significant associations observed for PFOSA but with results in varying directions. JF - Environmental health perspectives AU - Louis, Germaine M Buck AU - Chen, Zhen AU - Schisterman, Enrique F AU - Kim, Sungduk AU - Sweeney, Anne M AU - Sundaram, Rajeshwari AU - Lynch, Courtney D AU - Gore-Langton, Robert E AU - Barr, Dana Boyd AD - Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 57 EP - 63 VL - 123 IS - 1 KW - Environmental Pollutants KW - 0 KW - Fluorocarbons KW - Index Medicus KW - Humans KW - Linear Models KW - Adult KW - Environmental Exposure KW - Texas KW - Tandem Mass Spectrometry KW - Michigan KW - Male KW - Environmental Pollutants -- toxicity KW - Semen Analysis KW - Fluorocarbons -- toxicity KW - Semen -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1643406797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Perfluorochemicals+and+human+semen+quality%3A+the+LIFE+study.&rft.au=Louis%2C+Germaine+M+Buck%3BChen%2C+Zhen%3BSchisterman%2C+Enrique+F%3BKim%2C+Sungduk%3BSweeney%2C+Anne+M%3BSundaram%2C+Rajeshwari%3BLynch%2C+Courtney+D%3BGore-Langton%2C+Robert+E%3BBarr%2C+Dana+Boyd&rft.aulast=Louis&rft.aufirst=Germaine+M&rft.date=2015-01-01&rft.volume=123&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1307621 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-22 N1 - Date created - 2015-01-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Fertil Steril. 2000 Jan;73(1):43-50 [10632410] Paediatr Perinat Epidemiol. 2011 Sep;25(5):413-24 [21819423] Fertil Steril. 2001 Nov;76(5):879-83 [11704105] J Androl. 2002 Jan-Feb;23(1):25-43 [11780920] Best Pract Res Clin Endocrinol Metab. 2002 Jun;16(2):289-309 [12064894] J Androl. 2002 Sep-Oct;23(5):629-34 [12185096] Am J Epidemiol. 2003 Feb 15;157(4):355-63 [12578806] Environ Sci Technol. 2011 Oct 1;45(19):8037-45 [21469664] Toxicol Appl Pharmacol. 2012 Jan 15;258(2):248-55 [22119708] Reprod Toxicol. 2012 Jul;33(4):419-27 [21736937] Reprod Toxicol. 2012 Jul;33(4):577-83 [22449571] Hum Reprod. 2012 Aug;27(8):2532-40 [22647447] Methods Mol Biol. 2013;927:27-37 [22992901] Methods Mol Biol. 2013;927:147-64 [22992911] Hum Reprod. 2013 Jan;28(1):274-82 [23042799] Hum Reprod. 2013 Mar;28(3):599-608 [23250927] Environ Health Perspect. 2013 Apr;121(4):453-8 [23360585] Fertil Steril. 2013 Mar 1;99(3):673-7 [23391408] Urology. 2013 Dec;82(6):1296-9 [24094663] Chem Res Toxicol. 2003 Jun;16(6):775-81 [12807361] Environ Health Perspect. 2004 Jan;112(1):79-86 [14698935] Fertil Steril. 2004 Aug;82(2):358-66 [15302284] Crit Rev Toxicol. 2004 Jul-Aug;34(4):351-84 [15328768] J Androl. 1990 Jan-Feb;11(1):32-9 [2312397] Arch Androl. 1992 Sep-Oct;29(2):105-16 [1456832] Fertil Steril. 1994 Dec;62(6):1244-9 [7957992] Toxicol Appl Pharmacol. 1995 Sep;134(1):18-25 [7676454] Clin Chem. 1997 Dec;43(12):2281-91 [9439445] Am J Epidemiol. 1998 Nov 15;148(10):992-7 [9829871] Andrologia. 2004 Dec;36(6):337-45 [15541049] Anal Chem. 2005 Sep 15;77(18):6085-91 [16159145] Toxicology. 2005 Nov 5;215(1-2):126-48 [16146667] Environ Sci Technol. 2006 Jan 1;40(1):32-44 [16433330] Am J Epidemiol. 2006 Feb 15;163(4):374-83 [16394206] Epidemiology. 2006 Jul;17(4):440-9 [16755258] Hum Reprod. 2007 Jan;22(1):188-96 [16966350] Fertil Steril. 2007 Mar;87(3):554-64 [17140573] Reprod Biomed Online. 2007 Apr;14(4):418-21 [17425820] Toxicol Sci. 2007 Jul;98(1):206-15 [17400581] Science. 2007 Jul 13;317(5835):236-9 [17626882] Environ Health Perspect. 2007 Aug;115(8):1169-76 [17687443] Environ Health Perspect. 2007 Sep;115(9):1298-305 [17805419] Toxicol Sci. 2007 Oct;99(2):366-94 [17519394] Aquat Toxicol. 2007 Dec 30;85(4):267-77 [17980923] Environ Sci Technol. 2008 Feb 15;42(4):995-1003 [18351063] J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):188-220 [18368553] Risk Anal. 2008 Apr;28(2):251-69 [18419647] Int J Hyg Environ Health. 2009 May;212(3):239-70 [18565792] Environ Sci Technol. 2009 Jun 1;43(11):4037-43 [19569327] Environ Health Perspect. 2009 Jun;117(6):923-7 [19590684] Asian J Androl. 2010 Jan;12(1):99-103 [20111089] Crit Rev Toxicol. 2010 Aug;40(7):633-52 [20662712] Natl Med J India. 2010 May-Jun;23(3):134-6 [20949713] Fertil Steril. 2011 Jan;95(1):116-23 [20674912] J Urol. 2011 Feb;185(2):381-2 [21168161] Biol Reprod. 2011 May;84(5):1016-23 [21209418] Syst Biol Reprod Med. 2011 Jun;57(3):133-8 [21299480] J Androl. 2000 May-Jun;21(3):478-84 [10819457] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1307621 ER - TY - JOUR T1 - Preconception maternal and paternal exposure to persistent organic pollutants and birth size: the LIFE study. AN - 1643405640; 25095280 AB - Persistent organic pollutants (POPs) are developmental toxicants, but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored. We examined associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutants, with birth size measures. Parental serum concentrations of 9 organochlorine pesticides, 1 polybrominated biphenyl (PBB), 7 perfluoroalkyl chemicals (PFCs), 10 polybrominated diphenyl ethers (PBDEs), and 36 polychlorinated biphenyls (PCBs) were measured before conception for 234 couples. Differences in birth weight, length, head circumference, and ponderal index were estimated using multiple linear regression per 1-SD increase in natural log-transformed (ln-transformed) chemicals. Models were estimated separately for each parent and adjusted for maternal age, maternal prepregnancy body mass index (kilograms per meter squared) and other confounders, and all models included an interaction term between infant sex and each chemical. Among girls (n = 117), birth weight was significantly lower (range, 84-195 g) in association with a 1-SD increase in ln-transformed maternal serum concentrations of DDT, PBDE congeners 28 and 183, and paternal serum concentrations of PBDE-183 and PCB-167. Among boys (n = 113), maternal (PCBs 138, 153, 167, 170, 195, and 209 and perfluorooctane sulfonamide) and paternal (PCBs 172 and 195) serum concentrations of several POPs were statistically associated with lower birth weight (range, 98-170 g), whereas paternal concentrations of PBDEs (66, 99) were associated with higher birth weight. Differences in offspring head circumference, length, and ponderal index were also associated with parental exposures. Preconceptional maternal and paternal concentrations of several POPs were associated with statistically significant differences in birth size among offspring. JF - Environmental health perspectives AU - Robledo, Candace A AU - Yeung, Edwina AU - Mendola, Pauline AU - Sundaram, Rajeshwari AU - Maisog, Jose AU - Sweeney, Anne M AU - Barr, Dana Boyd AU - Louis, Germaine M Buck AD - Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 88 EP - 94 VL - 123 IS - 1 KW - Environmental Pollutants KW - 0 KW - Hydrocarbons, Halogenated KW - Pesticides KW - Index Medicus KW - Hydrocarbons, Halogenated -- toxicity KW - Humans KW - Infant, Newborn KW - Texas KW - Hydrocarbons, Halogenated -- blood KW - Pregnancy KW - Pesticides -- toxicity KW - Body Size -- drug effects KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Adult KW - Cohort Studies KW - Middle Aged KW - Michigan KW - Adolescent KW - Environmental Exposure -- adverse effects KW - Female KW - Male KW - Pesticides -- blood KW - Maternal Exposure -- adverse effects KW - Environmental Pollutants -- toxicity KW - Paternal Exposure -- adverse effects KW - Maternal Exposure -- statistics & numerical data KW - Birth Weight -- drug effects KW - Paternal Exposure -- statistics & numerical data KW - Environmental Pollutants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1643405640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Preconception+maternal+and+paternal+exposure+to+persistent+organic+pollutants+and+birth+size%3A+the+LIFE+study.&rft.au=Robledo%2C+Candace+A%3BYeung%2C+Edwina%3BMendola%2C+Pauline%3BSundaram%2C+Rajeshwari%3BMaisog%2C+Jose%3BSweeney%2C+Anne+M%3BBarr%2C+Dana+Boyd%3BLouis%2C+Germaine+M+Buck&rft.aulast=Robledo&rft.aufirst=Candace&rft.date=2015-01-01&rft.volume=123&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1308016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-22 N1 - Date created - 2015-01-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2009 Apr;117(4):660-7 [19440508] Environ Health Perspect. 2009 Aug;117(8):1244-9 [19672404] Environ Sci Technol. 2010 Jan 15;44(2):813-9 [20000818] Am J Obstet Gynecol. 2010 Feb;202(2):103-23 [20113689] Environ Health Perspect. 2010 Feb;118(2):297-302 [20123616] Curr Opin Pediatr. 2010 Apr;22(2):208-18 [20216314] Epidemiol Rev. 2010;32:70-81 [20378629] Sci Total Environ. 2010 Nov 1;408(23):5758-67 [20832846] Horm Behav. 2011 Mar;59(3):306-14 [20620140] Pediatrics. 2011 Apr;127(4):734-41 [21382949] Paediatr Perinat Epidemiol. 2011 Sep;25(5):413-24 [21819423] Chemosphere. 2011 Sep;84(10):1301-9 [21663933] Am J Epidemiol. 2011 Oct 15;174(8):885-92 [21878423] J Expo Sci Environ Epidemiol. 2012 Jan-Feb;22(1):60-9 [21971379] Environ Int. 2012 Apr;40:162-9 [21820740] Environ Health Perspect. 2012 Feb;120(2):162-70 [21997443] Environ Sci Pollut Res Int. 2012 Jul;19(6):1936-43 [22767291] Environ Health. 2012;11:49 [22817616] Int J Hyg Environ Health. 2013 Mar;216(2):184-94 [22494936] Ultrasound Obstet Gynecol. 2013 Feb;41(2):136-45 [22648955] Environ Health Perspect. 2013 Feb;121(2):231-6 [23151773] BMC Pregnancy Childbirth. 2013;13 Suppl 1:S3 [23445768] FASEB J. 2013 Oct;27(10):4226-43 [23845863] Anal Chem. 2003 Jan 1;75(1):71-7 [12530820] J Pediatr Endocrinol Metab. 2003 Apr-May;16(4):537-40 [12793605] Environ Health Perspect. 2003 Jul;111(9):1249-52 [12842781] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Aug 25;794(1):137-48 [12888206] Environ Health Perspect. 2004 Jan;112(1):69-78 [14698934] Environ Health Perspect. 2004 Jul;112(10):1116-24 [15238287] Environ Health Perspect. 2004 Oct;112(14):1403-8 [15471733] Schizophr Res. 2004 Dec 1;71(2-3):417-26 [15474913] Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495-500 [2505694] Clin Chim Acta. 1989 Oct 16;184(3):219-26 [2611996] Annu Rev Public Health. 1993;14:159-81 [7686758] Obstet Gynecol. 1995 Apr;85(4):625-30 [7898845] Semin Perinatol. 1995 Jun;19(3):222-40 [7570074] Clin Chem. 1997 Dec;43(12):2281-91 [9439445] Epidemiology. 1998 Mar;9(2):161-7 [9504284] Environ Health. 2004 Jan 28;3(1):1 [14748928] Epidemiology. 2005 Sep;16(5):641-7 [16135940] Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):506-13 [16039685] Anal Chem. 2005 Sep 15;77(18):6085-91 [16159145] Am J Epidemiol. 2005 Oct 15;162(8):717-25 [16120698] Am J Epidemiol. 2006 Feb 15;163(4):374-83 [16394206] Pediatr Res. 2007 Feb;61(2):243-50 [17237730] Environ Pollut. 2007 Mar;146(2):400-13 [16949712] Chemosphere. 2007 Jun;68(5):824-31 [17408721] Environ Health Perspect. 2007 Sep;115(9):1320-4 [17805422] Chemosphere. 2007 Oct;69(8):1295-304 [17617441] Environ Res. 2007 Nov;105(3):370-9 [17485077] Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):176-81 [18226072] Fertil Steril. 2008 Feb;89(2 Suppl):e111-6; discussion e117 [18308050] BJOG. 2008 Jun;115(7):886-93 [18485168] Chemosphere. 2009 Jan;74(3):428-33 [18986677] Environ Health Perspect. 2009 Mar;117(3):488-94 [19337527] Reprod Toxicol. 2009 Jun;27(3-4):212-30 [19429401] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1308016 ER - TY - JOUR T1 - Gene-directed enzyme prodrug therapy. AN - 1643147736; 25338741 AB - As one targeting strategy of prodrug delivery, gene-directed enzyme prodrug therapy (GDEPT) promises to realize the targeting through its three key features in cancer therapy-cell-specific gene delivery and expression, controlled conversion of prodrugs to drugs in target cells, and expanded toxicity to the target cells' neighbors through bystander effects. After over 20 years of development, multiple GDEPT systems have advanced into clinical trials. However, no GDEPT product is currently marketed as a drug, suggesting that there are still barriers to overcome before GDEPT becomes a standard therapy. In this review, we first provide a general introduction of this prodrug targeting strategy. Then, we utilize the four most thoroughly studied systems to illustrate components, mechanisms, preclinical and clinical results, and further development directions of GDEPT. These four systems are herpes simplex virus thymidine kinase/ganciclovir, cytosine deaminase/5-fluorocytosine, cytochrome P450/oxazaphosphorines, and nitroreductase/CB1954 system. Later, we focus our discussion on bystander effects including local and distant bystander effects. Lastly, we discuss carriers that are used to deliver genes for GDEPT including virus carriers and non-virus carriers. Among these carriers, the stem cell-based gene delivery system represents one of the newest carriers under development, and may brought about a breakthrough to the gene delivery issue of GDEPT. JF - The AAPS journal AU - Zhang, Jin AU - Kale, Vijay AU - Chen, Mingnan AD - The U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, Maryland, 20993, USA, jinzhang526@gmail.com. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 102 EP - 110 VL - 17 IS - 1 KW - Enzymes KW - 0 KW - Prodrugs KW - Index Medicus KW - Animals KW - Stem Cells -- cytology KW - Gene Transfer Techniques KW - Bystander Effect KW - Humans KW - Drug Design KW - Enzymes -- genetics KW - Drug Delivery Systems KW - Genetic Therapy -- methods KW - Prodrugs -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1643147736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Gene-directed+enzyme+prodrug+therapy.&rft.au=Zhang%2C+Jin%3BKale%2C+Vijay%3BChen%2C+Mingnan&rft.aulast=Zhang&rft.aufirst=Jin&rft.date=2015-01-01&rft.volume=17&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-014-9675-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-15 N1 - Date created - 2015-01-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mol Ther. 2007 May;15(5):1016-23 [17375076] Cancer Res. 2007 Jul 1;67(13):6304-13 [17616689] Clin Cancer Res. 2007 Oct 1;13(19):5847-54 [17908978] Cancer Res. 2007 Dec 15;67(24):11687-95 [18089798] Mol Ther. 2009 Jul;17(7):1292-9 [19367257] Curr Opin Mol Ther. 2009 Aug;11(4):421-32 [19649987] Cancer Gene Ther. 2009 Sep;16(9):723-30 [19363470] Stem Cells. 2009 Oct;27(10):2614-23 [19650040] Molecules. 2009;14(11):4517-45 [19924084] J Exp Clin Cancer Res. 2009;28:155 [20015348] In Vitro Cell Dev Biol Anim. 2010 Jun;46(6):497-501 [20135358] J Gene Med. 2010 Jul;12(7):572-9 [20603862] Gene Ther. 2010 Aug;17(8):1033-41 [20410928] Stem Cell Res Ther. 2010;1(3):25 [20699014] Indian J Med Res. 2010 Oct;132:415-22 [20966520] Cancer Gene Ther. 2010 Dec;17(12):837-43 [20689572] J Gene Med. 2010 Dec;12(12):1002-13 [21157824] J Clin Invest. 2011 Jan;121(1):161-73 [21183793] Gene Ther. 2011 Jan;18(1):73-81 [20720574] Stem Cells. 2011 Jan;29(1):11-9 [21280155] Blood. 2011 Jun 16;117(24):6469-78 [21531977] NMR Biomed. 2011 Dec;24(10):1361-8 [21387452] Cancer Lett. 2012 Nov 28;324(2):160-70 [22634584] PLoS One. 2012;7(9):e45590 [23029122] Sci Transl Med. 2013 May 8;5(184):184ra59 [23658244] Stem Cells Transl Med. 2013 Dec;2(12):983-92 [24167321] Stem Cell Res Ther. 2013;4(3):70 [23763837] J Clin Oncol. 2011 Sep 20;29(27):3611-9 [21844505] Scand J Gastroenterol. 1999 Oct;34(10):1033-41 [10563675] J Clin Oncol. 1999 Jul;17(7):2180-9 [10561274] J Natl Cancer Inst. 1999 Dec 1;91(23):2014-9 [10580026] Hum Gene Ther. 2000 Jan 1;11(1):77-89 [10646641] Cancer Gene Ther. 2000 Jan;7(1):20-6 [10678352] Cancer Gene Ther. 2000 Jan;7(1):74-82 [10678359] Cancer Gene Ther. 2000 Apr;7(4):557-62 [10811473] J Gene Med. 2000 May-Jun;2(3):148-64 [10894261] Cancer Gene Ther. 2000 Jul;7(7):1015-22 [10917204] Cancer Res. 2000 Aug 1;60(15):3989-99 [10945596] Oncogene. 2002 Mar 28;21(14):2141-53 [11948397] Curr Pharm Des. 2002;8(15):1349-61 [12052212] Cancer Res. 2002 Dec 1;62(23):6928-37 [12460909] Hum Gene Ther. 2003 Feb 10;14(3):227-41 [12639303] Hum Gene Ther. 2003 Mar 20;14(5):463-72 [12691611] Cancer Gene Ther. 2003 Oct;10(10):737-44 [14502226] Ann Neurol. 2003 Oct;54(4):479-87 [14520660] Cancer Res. 2003 Nov 1;63(21):7497-506 [14612551] Curr Pharm Des. 2004;10(5):531-55 [14965338] J Neurooncol. 2004 Jan;66(1-2):117-27 [15015777] J Clin Oncol. 2004 May 1;22(9):1546-52 [15051757] Cancer Cell. 2004 May;5(5):477-88 [15144955] Expert Opin Biol Ther. 2004 May;4(5):683-96 [15155160] Mol Ther. 2004 Nov;10(5):916-28 [15509509] Cancer Res. 1986 Oct;46(10):5276-81 [3019523] J Biol Chem. 1993 Mar 25;268(9):6332-7 [8384209] Biochem Pharmacol. 1993 Aug 3;46(3):503-10 [8347174] Cancer Res. 1993 Oct 1;53(19):4619-26 [8402637] Cancer Res. 1993 Nov 1;53(21):5274-83 [8221662] Cancer Res. 1994 Mar 15;54(6):1503-6 [8137255] Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8302-6 [8058798] J Immunol. 1995 May 15;154(10):5302-12 [7730633] Biochem Pharmacol. 1995 Mar 30;49(7):979-89 [7741770] Cancer Res. 1995 Nov 1;55(21):4808-12 [7585511] Arch Otolaryngol Head Neck Surg. 1996 Jul;122(7):746-9 [8663948] Blood. 1996 Sep 15;88(6):2192-200 [8822939] Hum Gene Ther. 1996 Aug 20;7(13):1567-76 [8864757] Hum Gene Ther. 1997 Jan 1;8(1):73-85 [8989997] Cancer Res. 1997 Feb 1;57(3):461-5 [9012474] Cancer Gene Ther. 1997 Mar-Apr;4(2):113-7 [9080120] Hum Gene Ther. 1997 Apr 10;8(6):709-17 [9113510] Cancer Gene Ther. 1997 Jul-Aug;4(4):246-52 [9253510] Cancer Res. 1997 Oct 1;57(19):4205-9 [9331076] Cancer Res. 1997 Oct 1;57(19):4325-32 [9331094] Endocrinology. 1997 Nov;138(11):4577-83 [9348181] Hum Gene Ther. 1997 Oct 10;8(15):1807-14 [9358030] J Natl Cancer Inst. 1998 Mar 4;90(5):370-80 [9498487] Gene Ther. 1998 Apr;5(4):507-13 [9614575] Prostate. 2000 Oct 1;45(2):149-57 [11027414] Hum Gene Ther. 2000 Nov 20;11(17):2389-401 [11096443] Nat Med. 2001 Jan;7(1):33-40 [11135613] Cancer Res. 2001 Mar 1;61(5):1805-9 [11280727] Cancer Res. 2001 Apr 1;61(7):3022-6 [11306482] Cancer Gene Ther. 2001 Mar;8(3):220-30 [11332993] Cancer Gene Ther. 2001 Jul;8(7):473-82 [11498768] Mol Pharmacol. 2001 Dec;60(6):1268-79 [11723234] Eur J Cancer. 2002 Jan;38(2):231-9 [11803140] Anticancer Res. 1998 Mar-Apr;18(2A):713-8 [9615710] Exp Cell Res. 1998 May 25;241(1):66-75 [9633514] Int J Radiat Oncol Biol Phys. 1998 Jul 1;41(4):883-7 [9652853] Cancer Res. 1998 Aug 15;58(16):3529-32 [9721854] Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8699-704 [10411938] J Urol. 1999 Sep;162(3 Pt 1):949-54 [10458414] Anticancer Res. 1999 May-Jun;19(3B):2163-5 [10472325] Oncogene. 2005 Feb 10;24(7):1231-43 [15592511] Clin Cancer Res. 2005 Feb 15;11(4):1512-20 [15746054] Cancer Gene Ther. 2005 May;12(5):497-508 [15746946] Adv Genet. 2005;54:235-55 [16096014] Cancer Gene Ther. 2005 Sep;12(9):757-68 [15832173] Toxicol In Vitro. 2006 Mar;20(2):176-86 [16293390] Cancer Gene Ther. 2007 Jan;14(1):57-65 [16874362] Mol Aspects Med. 2007 Feb;28(1):4-41 [17306358] Mol Ther. 2007 Apr;15(4):834-40 [17327829] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1208/s12248-014-9675-7 ER - TY - JOUR T1 - Development of Human Posture Simulation Method for Assessing Posture Angles and Spinal Loads AN - 1642628212; 21135917 AB - Video-based posture analysis employing a biomechanical model is gaining a growing popularity for ergonomic assessments. A human posture simulation method of estimating multiple body postural angles and spinal loads from a video record was developed to expedite ergonomic assessments. The method was evaluated by a repeated measures study design with three trunk flexion levels, two lift asymmetry levels, three viewing angles, and three trial repetitions as experimental factors. The study comprised two phases evaluating the accuracy of simulating self- and other people's lifting posture via a proxy of a computer-generated humanoid. The mean values of the accuracy of simulating self- and humanoid postures were 12 degree and 15 degree , respectively. The repeatability of the method for the same lifting condition was excellent (2 degree ). The least simulation error was associated with side viewing angle. The estimated back compressive force and moment, calculated by a three-dimensional biomechanical model, exhibited a range of 5% underestimation. The posture simulation method enables researchers to quantify simultaneously body posture angles and spinal loading variables with accuracy and precision comparable to on-screen posture-matching methods. JF - Human Factors and Ergonomics in Manufacturing AU - Lu, Ming-Lun AU - Waters, Thomas AU - Werren, Dwight AD - National Institute for Occupational Safety and Health, Taft Laboratories, Cincinnati, Ohio, USA. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 123 EP - 136 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 25 IS - 1 SN - 1090-8471, 1090-8471 KW - Health & Safety Science Abstracts KW - Simulation KW - Human factors KW - Posture KW - Lifting KW - Ergonomics KW - Biomechanics KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642628212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Factors+and+Ergonomics+in+Manufacturing&rft.atitle=Development+of+Human+Posture+Simulation+Method+for+Assessing+Posture+Angles+and+Spinal+Loads&rft.au=Lu%2C+Ming-Lun%3BWaters%2C+Thomas%3BWerren%2C+Dwight&rft.aulast=Lu&rft.aufirst=Ming-Lun&rft.date=2015-01-01&rft.volume=25&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Human+Factors+and+Ergonomics+in+Manufacturing&rft.issn=10908471&rft_id=info:doi/10.1002%2Fhfm.20534 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-02-18 N1 - SubjectsTermNotLitGenreText - Simulation; Human factors; Posture; Lifting; Biomechanics; Ergonomics DO - http://dx.doi.org/10.1002/hfm.20534 ER - TY - JOUR T1 - Characterization of cleaning and disinfecting tasks and product use among hospital occupations AN - 1642618571; 21189054 AB - Background Healthcare workers have an elevated prevalence of asthma and related symptoms associated with the use of cleaning/disinfecting products. The objective of this study was to identify and characterize cleaning/disinfecting tasks and products used among hospital occupations. Methods Workers from 14 occupations at five hospitals were monitored for 216 shifts, and work tasks and products used were recorded at five-minute intervals. The major chemical constituents of each product were identified from safety data sheets. Results Cleaning and disinfecting tasks were performed with a high frequency at least once per shift in many occupations. Medical equipment preparers, housekeepers, floor strippers/waxers, and endoscopy technicians spent on average 108-177min/shift performing cleaning/disinfecting tasks. Many occupations used products containing amines and quaternary ammonium compounds for >100min/shift. Conclusions This analysis demonstrates that many occupations besides housekeeping incur exposures to cleaning/disinfecting products, albeit for different durations and using products containing different chemicals. Am. J. Ind. Med. 58:101-111, 2015. copyright 2014 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Saito, Rena AU - Abbas Virji, M AU - Henneberger, Paul K AU - Humann, Michael J AU - LeBouf, Ryan F AU - Stanton, Marcia L AU - Liang, Xiaoming AU - Stefaniak, Aleksandr B AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 101 EP - 111 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 1 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642618571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Characterization+of+cleaning+and+disinfecting+tasks+and+product+use+among+hospital+occupations&rft.au=Saito%2C+Rena%3BAbbas+Virji%2C+M%3BHenneberger%2C+Paul+K%3BHumann%2C+Michael+J%3BLeBouf%2C+Ryan+F%3BStanton%2C+Marcia+L%3BLiang%2C+Xiaoming%3BStefaniak%2C+Aleksandr+B&rft.aulast=Saito&rft.aufirst=Rena&rft.date=2015-01-01&rft.volume=58&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22393 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-01-07 DO - http://dx.doi.org/10.1002/ajim.22393 ER - TY - JOUR T1 - Integrative genomic and transcriptomic characterization of matched primary and metastatic liver and colorectal carcinoma. AN - 1641858269; 25552933 AB - Metastasis is the main cause of cancer mortality but its process remains poorly understood and thus hampers more effective treatment and improved cancer prognosis. To search for metastasis driver genes responsible for tumor spread, we integrated genomic and transcriptomic profiles of 61 matched primary tumors and distant metastases of liver or colorectal carcinoma isolated by laser-capture microdissection and assayed by array-based technologies. We found that primary tumor lesions and their matched distant metastases were largely similar at the genomic and transcriptomic levels, but substantial differences could be found between primary tumors with or without accompanying metastases. Interestingly, metastasis genes were principally tumor type and organ site-specific. Despite distinct pathway enrichment, different metastasis gene sets shared common prognostic capacity and were predictive of hepatocellular carcinoma survival in an independent cohort. Thus, the metastatic propensity is inherent to the primary tumor and the lack of general metastasis genes necessitates the development of specific treatment modalities. JF - International journal of biological sciences AU - Roessler, Stephanie AU - Lin, Guoling AU - Forgues, Marshonna AU - Budhu, Anuradha AU - Hoover, Shelley AU - Simpson, R Mark AU - Wu, Xiaolin AU - He, Ping AU - Qin, Lun-Xiu AU - Tang, Zhao-You AU - Ye, Qing-Hai AU - Wang, Xin Wei AD - 1. Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA; ; 1. Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA; ; 2. Liver Cancer Institute, Fudan University, Shanghai, China; ; 3. Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA; ; 4. Laboratory of Molecular Technology, NCI-Frederick, SAIC-Frederick, Frederick, MD 21701, USA; ; 5. Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. ; 2. Liver Cancer Institute, Fudan University, Shanghai, China; Y1 - 2015 PY - 2015 DA - 2015 SP - 88 EP - 98 VL - 11 IS - 1 KW - Index Medicus KW - Organ site-specific metastasis KW - Liver cancer KW - Colon cancer KW - Profiling. KW - Gene Expression Profiling KW - Comparative Genomic Hybridization KW - Humans KW - Microarray Analysis KW - Laser Capture Microdissection KW - China KW - Colorectal Neoplasms -- secondary KW - Neoplasm Metastasis -- genetics KW - Neoplasm Metastasis -- physiopathology KW - Colorectal Neoplasms -- genetics KW - Liver Neoplasms -- secondary KW - Liver Neoplasms -- genetics KW - Gene Expression Regulation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1641858269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+biological+sciences&rft.atitle=Integrative+genomic+and+transcriptomic+characterization+of+matched+primary+and+metastatic+liver+and+colorectal+carcinoma.&rft.au=Roessler%2C+Stephanie%3BLin%2C+Guoling%3BForgues%2C+Marshonna%3BBudhu%2C+Anuradha%3BHoover%2C+Shelley%3BSimpson%2C+R+Mark%3BWu%2C+Xiaolin%3BHe%2C+Ping%3BQin%2C+Lun-Xiu%3BTang%2C+Zhao-You%3BYe%2C+Qing-Hai%3BWang%2C+Xin+Wei&rft.aulast=Roessler&rft.aufirst=Stephanie&rft.date=2015-01-01&rft.volume=11&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=International+journal+of+biological+sciences&rft.issn=1449-2288&rft_id=info:doi/10.7150%2Fijbs.10583 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-14 N1 - Date created - 2015-01-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Med. 2006 Aug;12(8):895-904 [16892035] Bioinformatics. 2005 Nov 15;21(22):4084-91 [16159913] Bioinformatics. 2007 Mar 15;23(6):657-63 [17234643] Nat Rev Genet. 2007 May;8(5):341-52 [17440531] Nat Rev Cancer. 2009 Apr;9(4):274-84 [19308067] Cancer Res. 2009 May 1;69(9):4059-66 [19366792] Nature. 2010 Feb 18;463(7283):899-905 [20164920] BMC Surg. 2010;10:27 [20875094] Cancer Res. 2010 Dec 15;70(24):10202-12 [21159642] Nat Rev Cancer. 2011 Feb;11(2):135-41 [21258397] Cell. 2011 Mar 4;144(5):646-74 [21376230] Nat Rev Cancer. 2011 Oct;11(10):735-48 [21941285] Cell. 2011 Oct 14;147(2):275-92 [22000009] N Engl J Med. 2012 Mar 8;366(10):883-92 [22397650] Gastroenterology. 2012 Apr;142(4):957-966.e12 [22202459] Nat Med. 2013 Nov;19(11):1423-37 [24202395] Ann Surg. 2002 Mar;235(3):373-82 [11882759] Nat Rev Cancer. 2002 Aug;2(8):563-72 [12154349] Nat Genet. 2003 Jan;33(1):49-54 [12469122] J Cancer Res Clin Oncol. 2003 Jan;129(1):43-51 [12618900] Nat Med. 2003 Apr;9(4):416-23 [12640447] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15901-5 [14665696] Cancer Res. 1988 Apr 1;48(7):1943-8 [3349467] Surg Clin North Am. 1997 Feb;77(1):27-48 [9092116] J Clin Invest. 2005 Jan;115(1):44-55 [15630443] Cancer Cell. 2006 Aug;10(2):99-111 [16904609] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.7150/ijbs.10583 ER - TY - JOUR T1 - Association of polymorphisms in drug transporter genes (SLCO1B1 and SLC10A1) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort. AN - 1640851596; 25498879 AB - This study investigated the association between genetic variants in two hepatic uptake transporter genes (SLCO1B1 and SLC10A1) and the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in a Chinese cohort. The frequencies and distributions of single nucleotide polymorphisms (SNPs) and haplotypes of these genes were compared among 89 incident ATDH cases and 356 matched ATDH-free controls using a multivariate conditional logistic regression analysis. After correction for potential confounding factors, significant differences were found in polymorphism of rs4149014 under an addictive model (P = 0.008) and a recessive model (P = 0.016). The result of haplotype analysis suggested that patients carrying at least one SLCO1B1*15 haplotype had a higher risk of ATDH (odds ratio (OR) = 1.74, 95% confidence intervals (CI): 1.04-2.90, P = 0.034) in comparison with those carrying SLCO1B1*1a or SLCO1B1*1b haplotypes. These findings indicate that genetic variants of SLCO1B1 are associated with the development of ATDH in Chinese population. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Tuberculosis (Edinburgh, Scotland) AU - Chen, Ru AU - Wang, Jing AU - Tang, Shaowen AU - Zhang, Yuan AU - Lv, Xiaozhen AU - Wu, Shanshan AU - Xia, Yinyin AU - Deng, Peiyuan AU - Ma, Yu AU - Tu, Dehua AU - Chen, Dafang AU - Zhan, Siyan AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China. ; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China. ; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada. ; Clinical Research Division, Peking University Institute of Mental Health, and Key Laboratory for Mental Health, Ministry of Health, Beijing, China. ; Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. ; Center for Drug Reassessment, State Food and Drug Administration, Beijing, China. ; Department of Tuberculosis Treatment, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China. ; Department of Tuberculosis Treatment, Beijing Institute for Tuberculosis Control, Beijing, China. ; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China. Electronic address: siyan-zhan@bjmu.edu.cn. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 68 EP - 74 VL - 95 IS - 1 KW - Antitubercular Agents KW - 0 KW - Organic Anion Transporters KW - Organic Anion Transporters, Sodium-Dependent KW - SLCO1B1 protein, human KW - Solute Carrier Organic Anion Transporter Family Member 1b1 KW - Symporters KW - sodium-bile acid cotransporter KW - 145420-23-1 KW - Index Medicus KW - Anti-tuberculosis drug KW - Drug transporter KW - Hepatotoxicity KW - Genotyping Techniques KW - Haplotypes -- genetics KW - Humans KW - Adult KW - Linkage Disequilibrium -- genetics KW - China -- ethnology KW - Male KW - Female KW - Tuberculosis, Pulmonary -- genetics KW - Organic Anion Transporters -- genetics KW - Chemical and Drug Induced Liver Injury -- genetics KW - Symporters -- genetics KW - Tuberculosis, Pulmonary -- ethnology KW - Organic Anion Transporters, Sodium-Dependent -- genetics KW - Antitubercular Agents -- adverse effects KW - Polymorphism, Single Nucleotide -- genetics KW - Tuberculosis, Pulmonary -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1640851596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tuberculosis+%28Edinburgh%2C+Scotland%29&rft.atitle=Association+of+polymorphisms+in+drug+transporter+genes+%28SLCO1B1+and+SLC10A1%29+and+anti-tuberculosis+drug-induced+hepatotoxicity+in+a+Chinese+cohort.&rft.au=Chen%2C+Ru%3BWang%2C+Jing%3BTang%2C+Shaowen%3BZhang%2C+Yuan%3BLv%2C+Xiaozhen%3BWu%2C+Shanshan%3BXia%2C+Yinyin%3BDeng%2C+Peiyuan%3BMa%2C+Yu%3BTu%2C+Dehua%3BChen%2C+Dafang%3BZhan%2C+Siyan&rft.aulast=Chen&rft.aufirst=Ru&rft.date=2015-01-01&rft.volume=95&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Tuberculosis+%28Edinburgh%2C+Scotland%29&rft.issn=1873-281X&rft_id=info:doi/10.1016%2Fj.tube.2014.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-18 N1 - Date created - 2014-12-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tube.2014.11.004 ER - TY - JOUR T1 - Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases. AN - 1640482809; 25536637 AB - Traditional Chinese Medicine (TCM) with its focus on herbal use became popular worldwide. Treatment was perceived as safe, with neglect of rare adverse reactions including liver injury. To compile worldwide cases of liver injury by herbal TCM, we undertook a selective literature search in the PubMed database and searched for the items Traditional Chinese Medicine, TCM, Traditional Asian Medicine, and Traditional Oriental Medicine, also combined with the terms herbal hepatotoxicity or herb induced liver injury. The search focused primarily on English-language case reports, case series, and clinical reviews. We identified reported hepatotoxicity cases in 77 relevant publications with 57 different herbs and herbal mixtures of TCM, which were further analyzed for causality by the Council for International Organizations of Medical Sciences (CIOMS) scale, positive reexposure test results, or both. Causality was established for 28/57 different herbs or herbal mixtures, Bai Xian Pi, Bo He, Ci Wu Jia, Chuan Lian Zi, Da Huang, Gan Cao, Ge Gen, Ho Shou Wu, Huang Qin, Hwang Geun Cho, Ji Gu Cao, Ji Xue Cao, Jin Bu Huan, Jue Ming Zi, Jiguja, Kudzu, Ling Yang Qing Fei Keli, Lu Cha, Rhen Shen, Ma Huang, Shou Wu Pian, Shan Chi, Shen Min, Syo Saiko To, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, and Zhen Chu Cao. In conclusion, this compilation of liver injury cases establishes causality for 28/57 different TCM herbs and herbal mixtures, aiding diagnosis for physicians who care for patients with liver disease possibly related to herbal TCM. JF - Annals of hepatology AU - Teschke, Rolf AU - Zhang, Li AU - Long, Hongzhu AU - Schwarzenboeck, Alexander AU - Schmidt-Taenzer, Wolfgang AU - Genthner, Alexander AU - Wolff, Albrecht AU - Frenzel, Christian AU - Schulze, Johannes AU - Eickhoff, Axel AD - Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt/ Main, Germany. ; Center for Drug Reevaluation, China Food and Drug Administration, Beijing, China. ; Department of Internal Medicine, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China. ; Department of Internal Medicine II, Division of Gastroenterology, Hepatology and Infectious Diseases, Friedrich Schiller University Jena, Germany. ; Department of Medicine I, University Medical Center Hamburg Eppendorf, Germany. ; Institute of Industrial, Environmental and Social Medicine, Medical Faculty of the Goethe University Frankfurt/Main, Germany. PY - 2015 SP - 7 EP - 19 VL - 14 IS - 1 SN - 1665-2681, 1665-2681 KW - Drugs, Chinese Herbal KW - 0 KW - Index Medicus KW - Humans KW - Drugs, Chinese Herbal -- adverse effects KW - Chemical and Drug Induced Liver Injury -- etiology KW - Medicine, Chinese Traditional KW - Phytotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1640482809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+hepatology&rft.atitle=Traditional+Chinese+Medicine+and+herbal+hepatotoxicity%3A+a+tabular+compilation+of+reported+cases.&rft.au=Teschke%2C+Rolf%3BZhang%2C+Li%3BLong%2C+Hongzhu%3BSchwarzenboeck%2C+Alexander%3BSchmidt-Taenzer%2C+Wolfgang%3BGenthner%2C+Alexander%3BWolff%2C+Albrecht%3BFrenzel%2C+Christian%3BSchulze%2C+Johannes%3BEickhoff%2C+Axel&rft.aulast=Teschke&rft.aufirst=Rolf&rft.date=2015-01-01&rft.volume=14&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Annals+of+hepatology&rft.issn=16652681&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-24 N1 - Date created - 2014-12-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Serum PCB concentrations in residents of Calcasieu and Lafayette Parishes, Louisiana with comparison to the U.S. population. AN - 1629585414; 25163413 AB - In 2002, a cross-sectional study designed to compare the serum dioxin toxic equivalent concentrations (TEQ) of a population-based sample of Calcasieu Parish, Louisiana residents, to Lafayette Parish was conducted. The mono-ortho polychlorinated biphenyls (PCBs) were measured in order to calculate the TEQ. We compared the sum of lipid adjusted serum concentrations of 27 PCB congeners (total PCBs) in residents of these two parishes and also by their demographic characteristics. The geometric means (GM) [standard errors (SE)] of the concentrations (ngg(-1) lipids) of total PCBs in participants from Calcasieu Parish and Lafayette Parish were 154 (11.8) and 168.6 (20.8) (T-test p=0.54), respectively. Various percentiles of the distribution of serum total PCB concentrations were similar in the two parishes. After adjusting by age and race in the ANCOVA regression model, the adjusted GM for the lipid adjusted total PCBs was statistically higher in the residents in Lafayette than in Calcasieu Parish regardless of age or race (P=0.007). The adjusted GM of lipid adjusted total PCBs for African Americans was significantly higher than for Whites (p<0.001). Serum total PCB levels in residents of both parishes increased linearly with age (P<0.001). The congener profiles were similar in residents of both parishes. We also compared the GMs of a sum of 8 PCBs in Calcasieu and Lafayette Parish residents to those from a representative sample of the U.S. general population in 2001-2002 and they were not significantly different between parishes or between the parish data and the U.S. general population. Published by Elsevier Ltd. JF - Chemosphere AU - Wong, Lee-Yang AU - Uddin, Mohammed S AU - Turner, Wayman AU - Ragin, Angela D AU - Dearwent, Steve AD - National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States. Electronic address: lyw8@cdc.gov. ; Agency for Toxic Substances and Disease Registry, Atlanta, GA 30341, United States. ; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States. ; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 156 EP - 162 VL - 118 KW - Dioxins KW - 0 KW - Environmental Pollutants KW - Lipids KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Population-based cross-sectional study KW - Polychlorinated biphenyls KW - Serum KW - Environmental health KW - United States KW - Lipids -- blood KW - Young Adult KW - Body Burden KW - Humans KW - Cross-Sectional Studies KW - Dioxins -- blood KW - Adult KW - Data Interpretation, Statistical KW - Middle Aged KW - Louisiana KW - Adolescent KW - Female KW - Male KW - Environmental Exposure -- statistics & numerical data KW - Polychlorinated Biphenyls -- blood KW - Environmental Exposure -- analysis KW - Environmental Pollutants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629585414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Serum+PCB+concentrations+in+residents+of+Calcasieu+and+Lafayette+Parishes%2C+Louisiana+with+comparison+to+the+U.S.+population.&rft.au=Wong%2C+Lee-Yang%3BUddin%2C+Mohammed+S%3BTurner%2C+Wayman%3BRagin%2C+Angela+D%3BDearwent%2C+Steve&rft.aulast=Wong&rft.aufirst=Lee-Yang&rft.date=2015-01-01&rft.volume=118&rft.issue=&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2014.07.073 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-16 N1 - Date created - 2014-12-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2014.07.073 ER - TY - JOUR T1 - Effect of silica and gold nanoparticles on macrophage proliferation, activation markers, cytokine production, and phagocytosis in vitro AN - 1647009885; 21327250 AB - The accumulation of durable nanoparticles (NPs) in macrophages following systemic administration is well described. The ultimate biological impact of this accumulation on macrophage function, however, is not fully understood. In this study, nontoxic doses of two durable NPs, SiO2 and Au, at particle sizes of ~10 nm and 300 nm were used to evaluate the effect of bioaccumulation on macrophage function in vitro using RAW 264.7 mouse macrophage-like cells as a model system. Cell proliferation, cell cycle, cytokine production, surface marker activation, and phagocytosis responses were evaluated through a panel of assays using flow cytometry and confocal microscopy. The most dramatic change in RAW 264.7 cell function was a reduction in phagocytosis as monitored by the uptake of Escherichia coli. Cells exposed to both 10 nm Au NPs and 10 nm SiO2 NPs showed ~50% decrease in phagocytosis, while the larger NPs caused a less dramatic reduction. In addition to modifying phagocytosis profiles, 10 nm SiO2 NPs caused changes in proliferation, cell cycle, and cell morphology. Au NPs had no effect on cell cycle, cytokine production, or surface markers and caused interference in phagocytosis in the form of quenching when the assay was performed via flow cytometry. Confocal microscopy analysis was used to minimize this interference and demonstrated that both sizes of Au NPs decreased the phagocytosis of E. coli. Overall, our results demonstrate that Au and SiO2 NP uptake by macrophages can influence macrophage phagocytosis in vitro without altering surface markers and cytokine production in vitro. While the biological impact of these findings remains unclear, our results indicate that bioaccumulation of durable NPs within the macrophages may lead to a suppression of bacterial uptake and possibly impair bactericidal activity. JF - International Journal of Nanomedicine AU - Bancos, Simona AU - Stevens, David L AU - Tyner, Katherine M AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2014/12/24/ PY - 2014 DA - 2014 Dec 24 SP - 183 EP - 206 PB - Dove Medical Press Ltd, Beechfield House Macclesfield SK11 0JL United Kingdom VL - 10 SN - 1176-9114, 1176-9114 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - bioaccumulation KW - phagocytosis KW - gold nanoparticles KW - silica nanoparticles KW - macrophage function KW - Particle size KW - Macrophages KW - Cell cycle KW - Cell activation KW - Flow cytometry KW - Silica KW - Bioaccumulation KW - Confocal microscopy KW - Escherichia coli KW - Cytology KW - Cytokines KW - Gold KW - Phagocytosis KW - Cell proliferation KW - nanoparticles KW - Bactericidal activity KW - Surface markers KW - nanotechnology KW - W 30950:Waste Treatment & Pollution Clean-up KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647009885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Nanomedicine&rft.atitle=Effect+of+silica+and+gold+nanoparticles+on+macrophage+proliferation%2C+activation+markers%2C+cytokine+production%2C+and+phagocytosis+in+vitro&rft.au=Bancos%2C+Simona%3BStevens%2C+David+L%3BTyner%2C+Katherine+M&rft.aulast=Bancos&rft.aufirst=Simona&rft.date=2014-12-24&rft.volume=10&rft.issue=&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Nanomedicine&rft.issn=11769114&rft_id=info:doi/10.2147%2FIJN.S72580 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Macrophages; Particle size; Cell cycle; Cell activation; Flow cytometry; Bioaccumulation; Silica; Confocal microscopy; Gold; Cytokines; Cytology; Cell proliferation; Phagocytosis; Bactericidal activity; nanoparticles; Surface markers; nanotechnology; Escherichia coli DO - http://dx.doi.org/10.2147/IJN.S72580 ER - TY - JOUR T1 - Evaluating Ebola therapies--the case for RCTs. AN - 1639498758; 25470568 JF - The New England journal of medicine AU - Cox, Edward AU - Borio, Luciana AU - Temple, Robert AD - From the Center for Drug Evaluation and Research (E.C., R.T.) and the Office of the Commissioner (L.B.), Food and Drug Administration, Silver Spring, MD. Y1 - 2014/12/18/ PY - 2014 DA - 2014 Dec 18 SP - 2350 EP - 2351 VL - 371 IS - 25 KW - Abridged Index Medicus KW - Index Medicus KW - Epidemics KW - Humans KW - Ebolavirus KW - Randomized Controlled Trials as Topic KW - Hemorrhagic Fever, Ebola -- mortality KW - Hemorrhagic Fever, Ebola -- therapy KW - Hemorrhagic Fever, Ebola -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639498758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Evaluating+Ebola+therapies--the+case+for+RCTs.&rft.au=Cox%2C+Edward%3BBorio%2C+Luciana%3BTemple%2C+Robert&rft.aulast=Cox&rft.aufirst=Edward&rft.date=2014-12-18&rft.volume=371&rft.issue=25&rft.spage=2350&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMp1414145 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-05 N1 - Date created - 2014-12-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1056/NEJMp1414145 ER - TY - JOUR T1 - Human biological monitoring for exposure assessment in response to an incident involving hazardous materials. AN - 1637568937; 24631920 AB - Biological monitoring in humans (HBM) is widely used in the field of occupational and environmental health. In the situation of an unexpected release of hazardous materials HBM may contribute to the medical support and treatment of exposed individuals from the general population or of emergency responders. Such exposure information may also be used to respond to individual concerns such as questions about a possible relationship between the chemicals released during the incident and health effects. In The Netherlands a guideline was prepared to support early decision-making about the possible use of HBM for exposure assessment during or as soon as possible following a chemical incident. The application of HBM in such an emergency setting is not much different from situations where HBM is normally used but there are some issues that need extra attention such as the choice of the biomarker, the biological media to be sampled, the time point at which biological samples should be collected, the ethics approval and technical implementation of the study protocol and the interpretation and communication of the study results. These issues addressed in the new guideline will support the use of HBM in the management of chemical disasters. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology letters AU - Scheepers, Paul T J AU - van Brederode, Nelly E AU - Bos, Peter M J AU - Nijhuis, Nicole J AU - van de Weerdt, Rik H J AU - van der Woude, Irene AU - Eggens, Martin L AD - Department for Health Evidence, Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: paul.scheepers@radboudumc.nl. ; National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: nelly.van.brederode@rivm.nl. ; National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: peter.bos@rivm.nl. ; Department of Environmental Health, Public Health Service Amsterdam, PO Box 2200, 1000 CE Amsterdam, The Netherlands. Electronic address: nnijhuis@ggd.amsterdam.nl. ; Public Health Services Gelderland-Midden, Postbus 5364, 6802 EJ Arnhem, The Netherlands. Electronic address: rik.van.de.weerdt@vggm.nl. ; Medical Emergency Preparedness and Planning Office, PO Box 9154, 3007 AD Rotterdam, The Netherlands. Electronic address: i.vanderwoude@veiligheidsregio-rr.nl. ; Public Health Service Groningen, Municipal Health Department, PO Box 584, 9700 AN Groningen, The Netherlands. Electronic address: martin.eggens@ggd.groningen.nl. Y1 - 2014/12/15/ PY - 2014 DA - 2014 Dec 15 SP - 295 EP - 305 VL - 231 IS - 3 KW - Biomarkers KW - 0 KW - Hazardous Substances KW - Index Medicus KW - Health surveillance KW - Hazardous materials KW - Emergency response KW - Disaster management KW - Acute toxicity KW - Exposure assessment KW - Humans KW - Guidelines as Topic KW - Netherlands KW - Biomarkers -- analysis KW - Environmental Exposure -- analysis KW - Chemical Hazard Release KW - Environmental Exposure -- adverse effects KW - Decision Making KW - Hazardous Substances -- analysis KW - Environmental Monitoring -- methods KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1637568937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Human+biological+monitoring+for+exposure+assessment+in+response+to+an+incident+involving+hazardous+materials.&rft.au=Scheepers%2C+Paul+T+J%3Bvan+Brederode%2C+Nelly+E%3BBos%2C+Peter+M+J%3BNijhuis%2C+Nicole+J%3Bvan+de+Weerdt%2C+Rik+H+J%3Bvan+der+Woude%2C+Irene%3BEggens%2C+Martin+L&rft.aulast=Scheepers&rft.aufirst=Paul+T&rft.date=2014-12-15&rft.volume=231&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2014.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-11 N1 - Date created - 2014-12-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2014.03.002 ER - TY - JOUR T1 - Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. AN - 1627071861; 25027329 AB - Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci. JF - Human molecular genetics AU - Wang, Zhaoming AU - Zhu, Bin AU - Zhang, Mingfeng AU - Parikh, Hemang AU - Jia, Jinping AU - Chung, Charles C AU - Sampson, Joshua N AU - Hoskins, Jason W AU - Hutchinson, Amy AU - Burdette, Laurie AU - Ibrahim, Abdisamad AU - Hautman, Christopher AU - Raj, Preethi S AU - Abnet, Christian C AU - Adjei, Andrew A AU - Ahlbom, Anders AU - Albanes, Demetrius AU - Allen, Naomi E AU - Ambrosone, Christine B AU - Aldrich, Melinda AU - Amiano, Pilar AU - Amos, Christopher AU - Andersson, Ulrika AU - Andriole, Gerald AU - Andrulis, Irene L AU - Arici, Cecilia AU - Arslan, Alan A AU - Austin, Melissa A AU - Baris, Dalsu AU - Barkauskas, Donald A AU - Bassig, Bryan A AU - Beane Freeman, Laura E AU - Berg, Christine D AU - Berndt, Sonja I AU - Bertazzi, Pier Alberto AU - Biritwum, Richard B AU - Black, Amanda AU - Blot, William AU - Boeing, Heiner AU - Boffetta, Paolo AU - Bolton, Kelly AU - Boutron-Ruault, Marie-Christine AU - Bracci, Paige M AU - Brennan, Paul AU - Brinton, Louise A AU - Brotzman, Michelle AU - Bueno-de-Mesquita, H Bas AU - Buring, Julie E AU - Butler, Mary Ann AU - Cai, Qiuyin AU - Cancel-Tassin, Geraldine AU - Canzian, Federico AU - Cao, Guangwen AU - Caporaso, Neil E AU - Carrato, Alfredo AU - Carreon, Tania AU - Carta, Angela AU - Chang, Gee-Chen AU - Chang, I-Shou AU - Chang-Claude, Jenny AU - Che, Xu AU - Chen, Chien-Jen AU - Chen, Chih-Yi AU - Chen, Chung-Hsing AU - Chen, Constance AU - Chen, Kuan-Yu AU - Chen, Yuh-Min AU - Chokkalingam, Anand P AU - Chu, Lisa W AU - Clavel-Chapelon, Francoise AU - Colditz, Graham A AU - Colt, Joanne S AU - Conti, David AU - Cook, Michael B AU - Cortessis, Victoria K AU - Crawford, E David AU - Cussenot, Olivier AU - Davis, Faith G AU - De Vivo, Immaculata AU - Deng, Xiang AU - Ding, Ti AU - Dinney, Colin P AU - Di Stefano, Anna Luisa AU - Diver, W Ryan AU - Duell, Eric J AU - Elena, Joanne W AU - Fan, Jin-Hu AU - Feigelson, Heather Spencer AU - Feychting, Maria AU - Figueroa, Jonine D AU - Flanagan, Adrienne M AU - Fraumeni, Joseph F AU - Freedman, Neal D AU - Fridley, Brooke L AU - Fuchs, Charles S AU - Gago-Dominguez, Manuela AU - Gallinger, Steven AU - Gao, Yu-Tang AU - Gapstur, Susan M AU - Garcia-Closas, Montserrat AU - Garcia-Closas, Reina AU - Gastier-Foster, Julie M AU - Gaziano, J Michael AU - Gerhard, Daniela S AU - Giffen, Carol A AU - Giles, Graham G AU - Gillanders, Elizabeth M AU - Giovannucci, Edward L AU - Goggins, Michael AU - Gokgoz, Nalan AU - Goldstein, Alisa M AU - Gonzalez, Carlos AU - Gorlick, Richard AU - Greene, Mark H AU - Gross, Myron AU - Grossman, H Barton AU - Grubb, Robert AU - Gu, Jian AU - Guan, Peng AU - Haiman, Christopher A AU - Hallmans, Goran AU - Hankinson, Susan E AU - Harris, Curtis C AU - Hartge, Patricia AU - Hattinger, Claudia AU - Hayes, Richard B AU - He, Qincheng AU - Helman, Lee AU - Henderson, Brian E AU - Henriksson, Roger AU - Hoffman-Bolton, Judith AU - Hohensee, Chancellor AU - Holly, Elizabeth A AU - Hong, Yun-Chul AU - Hoover, Robert N AU - Hosgood, H Dean AU - Hsiao, Chin-Fu AU - Hsing, Ann W AU - Hsiung, Chao Agnes AU - Hu, Nan AU - Hu, Wei AU - Hu, Zhibin AU - Huang, Ming-Shyan AU - Hunter, David J AU - Inskip, Peter D AU - Ito, Hidemi AU - Jacobs, Eric J AU - Jacobs, Kevin B AU - Jenab, Mazda AU - Ji, Bu-Tian AU - Johansen, Christoffer AU - Johansson, Mattias AU - Johnson, Alison AU - Kaaks, Rudolf AU - Kamat, Ashish M AU - Kamineni, Aruna AU - Karagas, Margaret AU - Khanna, Chand AU - Khaw, Kay-Tee AU - Kim, Christopher AU - Kim, In-Sam AU - Kim, Jin Hee AU - Kim, Yeul Hong AU - Kim, Young-Chul AU - Kim, Young Tae AU - Kang, Chang Hyun AU - Jung, Yoo Jin AU - Kitahara, Cari M AU - Klein, Alison P AU - Klein, Robert AU - Kogevinas, Manolis AU - Koh, Woon-Puay AU - Kohno, Takashi AU - Kolonel, Laurence N AU - Kooperberg, Charles AU - Kratz, Christian P AU - Krogh, Vittorio AU - Kunitoh, Hideo AU - Kurtz, Robert C AU - Kurucu, Nilgun AU - Lan, Qing AU - Lathrop, Mark AU - Lau, Ching C AU - Lecanda, Fernando AU - Lee, Kyoung-Mu AU - Lee, Maxwell P AU - Le Marchand, Loic AU - Lerner, Seth P AU - Li, Donghui AU - Liao, Linda M AU - Lim, Wei-Yen AU - Lin, Dongxin AU - Lin, Jie AU - Lindstrom, Sara AU - Linet, Martha S AU - Lissowska, Jolanta AU - Liu, Jianjun AU - Ljungberg, Börje AU - Lloreta, Josep AU - Lu, Daru AU - Ma, Jing AU - Malats, Nuria AU - Mannisto, Satu AU - Marina, Neyssa AU - Mastrangelo, Giuseppe AU - Matsuo, Keitaro AU - McGlynn, Katherine A AU - McKean-Cowdin, Roberta AU - McNeill, Lorna H AU - McWilliams, Robert R AU - Melin, Beatrice S AU - Meltzer, Paul S AU - Mensah, James E AU - Miao, Xiaoping AU - Michaud, Dominique S AU - Mondul, Alison M AU - Moore, Lee E AU - Muir, Kenneth AU - Niwa, Shelley AU - Olson, Sara H AU - Orr, Nick AU - Panico, Salvatore AU - Park, Jae Yong AU - Patel, Alpa V AU - Patino-Garcia, Ana AU - Pavanello, Sofia AU - Peeters, Petra H M AU - Peplonska, Beata AU - Peters, Ulrike AU - Petersen, Gloria M AU - Picci, Piero AU - Pike, Malcolm C AU - Porru, Stefano AU - Prescott, Jennifer AU - Pu, Xia AU - Purdue, Mark P AU - Qiao, You-Lin AU - Rajaraman, Preetha AU - Riboli, Elio AU - Risch, Harvey A AU - Rodabough, Rebecca J AU - Rothman, Nathaniel AU - Ruder, Avima M AU - Ryu, Jeong-Seon AU - Sanson, Marc AU - Schned, Alan AU - Schumacher, Fredrick R AU - Schwartz, Ann G AU - Schwartz, Kendra L AU - Schwenn, Molly AU - Scotlandi, Katia AU - Seow, Adeline AU - Serra, Consol AU - Serra, Massimo AU - Sesso, Howard D AU - Severi, Gianluca AU - Shen, Hongbing AU - Shen, Min AU - Shete, Sanjay AU - Shiraishi, Kouya AU - Shu, Xiao-Ou AU - Siddiq, Afshan AU - Sierrasesumaga, Luis AU - Sierri, Sabina AU - Loon Sihoe, Alan Dart AU - Silverman, Debra T AU - Simon, Matthias AU - Southey, Melissa C AU - Spector, Logan AU - Spitz, Margaret AU - Stampfer, Meir AU - Stattin, Par AU - Stern, Mariana C AU - Stevens, Victoria L AU - Stolzenberg-Solomon, Rachael Z AU - Stram, Daniel O AU - Strom, Sara S AU - Su, Wu-Chou AU - Sund, Malin AU - Sung, Sook Whan AU - Swerdlow, Anthony AU - Tan, Wen AU - Tanaka, Hideo AU - Tang, Wei AU - Tang, Ze-Zhang AU - Tardon, Adonina AU - Tay, Evelyn AU - Taylor, Philip R AU - Tettey, Yao AU - Thomas, David M AU - Tirabosco, Roberto AU - Tjonneland, Anne AU - Tobias, Geoffrey S AU - Toro, Jorge R AU - Travis, Ruth C AU - Trichopoulos, Dimitrios AU - Troisi, Rebecca AU - Truelove, Ann AU - Tsai, Ying-Huang AU - Tucker, Margaret A AU - Tumino, Rosario AU - Van Den Berg, David AU - Van Den Eeden, Stephen K AU - Vermeulen, Roel AU - Vineis, Paolo AU - Visvanathan, Kala AU - Vogel, Ulla AU - Wang, Chaoyu AU - Wang, Chengfeng AU - Wang, Junwen AU - Wang, Sophia S AU - Weiderpass, Elisabete AU - Weinstein, Stephanie J AU - Wentzensen, Nicolas AU - Wheeler, William AU - White, Emily AU - Wiencke, John K AU - Wolk, Alicja AU - Wolpin, Brian M AU - Wong, Maria Pik AU - Wrensch, Margaret AU - Wu, Chen AU - Wu, Tangchun AU - Wu, Xifeng AU - Wu, Yi-Long AU - Wunder, Jay S AU - Xiang, Yong-Bing AU - Xu, Jun AU - Yang, Hannah P AU - Yang, Pan-Chyr AU - Yatabe, Yasushi AU - Ye, Yuanqing AU - Yeboah, Edward D AU - Yin, Zhihua AU - Ying, Chen AU - Yu, Chong-Jen AU - Yu, Kai AU - Yuan, Jian-Min AU - Zanetti, Krista A AU - Zeleniuch-Jacquotte, Anne AU - Zheng, Wei AU - Zhou, Baosen AU - Mirabello, Lisa AU - Savage, Sharon A AU - Kraft, Peter AU - Chanock, Stephen J AU - Yeager, Meredith AU - Landi, Maria Terese AU - Shi, Jianxin AU - Chatterjee, Nilanjan AU - Amundadottir, Laufey T AD - Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA. ; Division of Cancer Epidemiology and Genetics. ; Korle Bu Teaching Hospital, PO BOX 77, Accra, Ghana, University of Ghana Medical School, PO Box 4236, Accra, Ghana. ; Unit of Epidemiology, Institute of Environmental Medicine. ; Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK. ; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA. ; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA. ; Public Health Division of Gipuzkoa, Basque Regional Health Department, San Sebastian, Spain, CIBERESP, CIBER Epidemiologia y Salud Publica, Madrid, Spain. ; Geisel School of Medicine at Dartmouth, Hanover, NH, USA. ; Department of Radiation Sciences, Oncology. ; Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO, USA. ; Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, Toronto, ON, Canada. ; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Italy. ; Department of Obstetrics and Gynecology and Department of Population Health, New York University School of Medicine, New York, NY, USA, New York University Cancer Institute, New York, NY, USA. ; Department of Epidemiology, University of Washington, Seattle, WA, USA. ; Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine and. ; Division of Cancer Epidemiology and Genetics, Division of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA. ; Division of Cancer Prevention. ; Department of Clinical Sciences and Community Health, University of Milan, Department of Preventive Medicine, Fondazione IRCCS Ca' Granda Policlinico Hospital, Milan, Italy. ; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA, International Epidemiology Institute, Rockville, MD, USA. ; Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany. ; Institute for Translational Epidemiology, Hematology and Medical Oncology, Mount Sinai Hospital School of Medicine, New York, NY, USA. ; Division of Cancer Epidemiology and Genetics, Department of Oncology, University of Cambridge, Cambridge CB2 2RE, UK. ; Institut National de la Sante et de la Recherche Medicale (INSERM) and Institut Gustave Roussy, Villejuif, France. ; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. ; International Agency for Research on Cancer (IARC-WHO), Lyon, France. ; Westat, Rockville, MD, USA. ; National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands. ; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. ; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, USA. ; CeRePP, Paris, France, UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France. ; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. ; Department of Epidemiology, Second Military Medical University, Shanghai, China. ; Medical Oncology Department, Hospital Ramón y Cajal, Madrid, Spain. ; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. ; National Institute of Cancer Research. ; Department of Abdominal Surgery and. ; Genomics Research Center, Academia Sinica, Taipei, Taiwan, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan. ; Cancer Center, China Medical University Hospital, Taipei, Taiwan. ; Program in Molecular and Genetic Epidemiology. ; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. ; Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine and Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, College of Medical Science and Technology, Taipei Medical University, Taiwan. ; School of Public Health, University of California, Berkeley, CA, USA. ; Cancer Prevention Institute of California, Fremont, CA, USA. ; Inserm, Centre for Research in Epidemiology and Population Health (CESP), Villejuif, France. ; Washington University School of Medicine, St Louis, MO, USA. ; Urologic Oncology, University of Colorado, Aurora, CO, USA. ; CeRePP, Paris, France, AP-HP, Department of Urology, Tenon Hospital, GHU-Est, Paris, France, UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France. ; Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, AB, Canada T6G 2R3. ; Program in Molecular and Genetic Epidemiology, Department of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ; Shanxi Cancer Hospital, Taiyuan, Shanxi, People's Republic of China. ; Department of Urology. ; Service de Neurologie Mazarin, GH Pitie-Salpetriere, APHP, and UMR 975 INSERM-UPMC, CRICM, Paris, France. ; Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA. ; Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain. ; Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, Bethesda, MD, USA. ; Shanghai Cancer Institute, Shanghai, People's Republic of China. ; Institute for Health Research, Kaiser Permanente, Denver, CO, USA. ; UCL Cancer Institute, Huntley Street, London WC1E 6BT, UK, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK. ; Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA. ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Channing Laboratory, Department of Medicine. ; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain. ; Samuel Lunenfeld Research Institute and. ; Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotaong University School of Medicine, Shanghai, China. ; Division of Cancer Epidemiology and Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK. ; Unidad de Investigación, Hospital Universitario de Canarias, La Laguna, Spain. ; Nationwide Children's Hospital, and The Ohio State University Department of Pathology and Pediatrics, Columbus, OH, USA. ; Division of Preventive Medicine, Department of Medicine and Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Massachusetts Veteran's Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA. ; Office of Cancer Genomics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. ; Information Management Services Inc., Calverton, MD, USA. ; Cancer Epidemiology Centre, The Cancer Council Victoria & Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Victoria, Australia. ; Division of Cancer Control and Population Sciences and. ; Program in Molecular and Genetic Epidemiology, Department of Nutrition and. ; Department of Oncology, Department of Pathology and Department of Medicine, The Sol Goldman Pancreatic Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. ; Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain. ; Albert Einstein College of Medicine, The Children's Hospital at Montefiore, Bronx, NY, USA. ; Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA. ; Department of Urology, Washington University School of Medicine, St Louis, MO, USA. ; Department of Epidemiology. ; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China. ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. ; Department of Public Health and Clinical Medicine/Nutritional Research. ; Channing Laboratory, Department of Medicine. ; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. ; Laboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy. ; Division of Cancer Epidemiology and Genetics, Department of Population Health, New York University Langone Medical Center and Department of Environmental Medicine, New York University Langone Medical Center, New York University Cancer Institute, New York, NY, USA. ; Center for Cancer Research and. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea, Department of Preventive Medicine and. ; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. ; Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences and Taiwan Lung Cancer Tissue/Specimen Information Resource Center, National Health Research Institutes, Zhunan, Taiwan. ; Cancer Prevention Institute of California, Fremont, CA, USA, Stanford Cancer Institute, Stanford University, Stanford, CA, USA. ; Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences and. ; Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China. ; Program in Molecular and Genetic Epidemiology, Department of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Broad Institute of Harvard and MIT, Cambridge, MA, USA. ; Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan. ; Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA, Bioinformed, LLC, Gaithersburg, MD, USA. ; Department of Oncology, Finsen Center, Rigshospitalet, Copenhagen, Denmark, Unit of Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark. ; International Agency for Research on Cancer (IARC-WHO), Lyon, France, Department of Public Health and Clinical Medicine. ; Vermont Cancer Registry, Burlington, VT, USA. ; Group Health Research Institute, Seattle, WA, USA. ; School of Clinical Medicine, University of Cambridge, UK. ; Department of Biochemistry and Department of Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. ; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. ; Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Department of Internal Medicine and Division of Brain and Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea. ; Lung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasun-eup, Republic of Korea. ; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. ; Department of Oncology, Department of Pathology and Department of Medicine, The Sol Goldman Pancreatic Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ; Department of Medicine and. ; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, National School of Public Health, Athens, Greece. ; Duke-NUS Graduate Medical School, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore. ; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan. ; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA. ; Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. ; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan, Department of Respiratory Medicine, Mitsui Memorial Hospital, Tokyo, Japan. ; Department of Pediatric Oncology, A.Y. Ankara Oncology Training and Research Hospital, Yenimahalle- Ankara, Turkey. ; Centre National de Genotypage, IG/CEA, Evry Cedex, France, Centre d'Étude du Polymorphism Humain (CEPH), Paris, France. ; Texas Children's Cancer and Hematology Centers. ; Department of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona, Spain. ; Department of Preventive Medicine and Department of Environmental Health, Korea National Open University, Seoul, Republic of Korea. ; Scott Department of Urology and. ; Department of Gastrointestinal Medical Oncology. ; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. ; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ; Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland. ; Human Genetics Division, Genome Institute of Singapore, Singapore, School of Life Sciences, Anhui Medical University, Hefei, China. ; Department of Surgical and Perioperative Sciences, Urology and Andrology and. ; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. ; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China. ; Department of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ; Centro Nacional de Investigaciones Oncologicas, Melchor Fernández Almagro, 3, Madrid E-28029, Spain. ; National Institute for Health and Welfare, Helsinki, Finland. ; Lucile Packard Children's Hospital, Stanford University, Palo Alto, CA, USA. ; Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy. ; Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan, Department of Preventive Medicine, Kyushu University Faculty of Medical Scicence, Fukuoka, Japan. ; Department of Health Disparities Research, Division of OVP, Cancer Prevention and Population Sciences, and Center for Community-Engaged Translational Research, Duncan Family Institute and. ; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. ; Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China. ; Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI, USA. ; Health Sciences Research Institute, University of Warwick, Coventry, UK. ; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ; Complex Traits Genetics Team and. ; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy. ; Department of Biochemistry and Department of Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea, Lung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea. ; Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Utrecht, The Netherlands, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. ; Nofer Institute of Occupational Medicine, Lodz, Poland. ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ; Department of Epidemiology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People's Republic of China. ; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. ; Yale School of Public Health, New Haven, CT, USA. ; Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea. ; Karmanos Cancer Institute and Department of Oncology and. ; Karmanos Cancer Institute and Department of Family Medicine and Public Health Sciences, Wayne State University School of Medicine, Detroit, MI, USA. ; Maine Cancer Registry, Augusta, ME, USA. ; Centre for Research in Occupational Health, Universitat Pompeu Fabra, Barcelona, Spain, CIBER of Epidemiology and Public Health (CIBERESP). ; Department of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA. ; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK. ; Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. ; Department of Surgery, Division of Cardiothoracic Surgery, Queen Mary Hospital, Hong Kong, China. ; Department of Neurosurgery, University of Bonn Medical Center, Bonn, Germany. ; Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia. ; University of Minnesota, Minneapolis, MN, USA. ; Dan L. Duncan Center, Baylor College of Medicine, Houston, TX, USA. ; Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ; Department of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan. ; Department of Surgical and Perioperative Sciences/Surgery, Umeå University, Umeå, Sweden. ; Department of Thoracic and Cardiovascular Surgery, Seoul St Mary's Hospital, Seoul, South Korea. ; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK, Division of Breast Cancer Research, Institute of Cancer Research, London, UK. ; Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain. ; Sir Peter MacCallum Department of Oncology, University of Melbourne, St Andrew's Place, East Melbourne, VIC, Australia. ; Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK. ; Danish Cancer Society Research Center, Copenhagen, Denmark. ; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. ; Department of Pulmonary Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan. ; Cancer Registry Associazione Iblea Ricerca Epidemiologica, Onlus and Asp Ragusa, Ragusa Italy. ; Kaiser Permanente Northern California, Oakland, CA, USA. ; Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands. ; Imperial College, London, UK, Human Genetics Foundation (HuGeF), Torino Italy. ; National Research Centre for the Working Environment, Copenhagen, Denmark, National Food Institute, Technical University of Denmark, Soborg, Denmark. ; Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA, Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. ; Division of Cancer Etiology, Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, CA, USA. ; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway, Department of Research, Cancer Registry of Norway, Oslo, Norway, Department of Medical Epidemiology and Biostatistics and Samfundet Folkhälsan, Helsinki, Finland. ; University of California San Francisco, San Francisco, CA, USA. ; Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. ; Department of Pathology and. ; Guangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. ; School of Public Health, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China. ; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital and. ; University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA and. ; Department of Population Health, New York University School of Medicine, New York, NY, USA, New York University Cancer Institute, New York, NY, USA. ; Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. ; Division of Cancer Epidemiology and Genetics, amundadottirl@mail.nih.gov. Y1 - 2014/12/15/ PY - 2014 DA - 2014 Dec 15 SP - 6616 EP - 6633 VL - 23 IS - 24 KW - CLPTM1L protein, human KW - 0 KW - Membrane Proteins KW - Neoplasm Proteins KW - TERT protein, human KW - EC 2.7.7.49 KW - Telomerase KW - Index Medicus KW - Risk KW - Polymorphism, Single Nucleotide KW - Odds Ratio KW - Alleles KW - Gene Frequency KW - DNA Methylation KW - Humans KW - Genetic Predisposition to Disease KW - Computational Biology KW - Epigenesis, Genetic KW - Male KW - Female KW - Genome-Wide Association Study KW - Gene Expression Regulation, Neoplastic KW - Neoplasms -- pathology KW - Genetic Loci KW - Neoplasm Proteins -- genetics KW - Chromosomes, Human, Pair 5 -- chemistry KW - Telomerase -- genetics KW - Membrane Proteins -- genetics KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627071861?accountid=14244 L2 - 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AN - 1620587832; 25366408 AB - The identification of bacteria based on mass spectra produced by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has become routine since its introduction in 1996. The major drawback is that bacterial patterns produced by MALDI are dependent on sample preparation prior to analysis. This results in poor reproducibility in identifying bacterial types and between laboratories. The need for a more broadly applicable and useful sample handling procedure is warranted. Thymol was added to the suspension solvent of bacteria prior to MALDI analysis. The suspension solvent consisted of ethanol, water and TFA. The bacterium was added to the thymol suspension solvent and heated. An aliquot of the bacterial suspension was mixed directly with the matrix solution at a 9:1 ratio, matrix/bacteria solution, respectively. The mixture was then placed on the MALDI plate and allowed to air dry before MALDI analysis. The thymol method improved the quality of spectra and number of peaks when compared to other sample preparation procedures studied. The bacterium-identifying biomarkers assigned to four strains of E. coli were statistically 95% reproducible analyzed on three separate days. The thymol method successfully differentiated between the four E. coli strains. In addition, the thymol procedure could identify nine out of ten S. enterica serovars over a 3-day period and nine S. Typhimurium strains from the other ten serovars 90% of the time over the same period. The thymol method can identify certain bacteria at the sub-species level and yield reproducible results over time. It improves the quality of spectra by increasing the number of peaks when compared to the other sample preparation methods assessed in this study. Published in 2014. This article is a U.S. Government work and is in the public domain in the USA. Published in 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Rapid communications in mass spectrometry : RCM AU - Holland, Ricky D AU - Wilkes, Jon G AU - Cooper, Willie M AU - Alusta, Pierre AU - Williams, Anna AU - Pearce, Bruce AU - Beaudoin, Michael AU - Buzatu, Dan AD - Division of Systems Biology/Innovative Safety and Technologies Branch, USFDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. Y1 - 2014/12/15/ PY - 2014 DA - 2014 Dec 15 SP - 2617 EP - 2626 VL - 28 IS - 23 KW - Biomarkers KW - 0 KW - Thymol KW - 3J50XA376E KW - Index Medicus KW - Biomarkers -- chemistry KW - Reproducibility of Results KW - Biomarkers -- analysis KW - Thymol -- chemistry KW - Bacterial Typing Techniques -- methods KW - Bacteria -- classification KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods KW - Bacteria -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1620587832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Thymol+treatment+of+bacteria+prior+to+matrix-assisted+laser+desorption%2Fionization+time-of-flight+mass+spectrometric+analysis+aids+in+identifying+certain+bacteria+at+the+subspecies+level.&rft.au=Holland%2C+Ricky+D%3BWilkes%2C+Jon+G%3BCooper%2C+Willie+M%3BAlusta%2C+Pierre%3BWilliams%2C+Anna%3BPearce%2C+Bruce%3BBeaudoin%2C+Michael%3BBuzatu%2C+Dan&rft.aulast=Holland&rft.aufirst=Ricky&rft.date=2014-12-15&rft.volume=28&rft.issue=23&rft.spage=2617&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=1097-0231&rft_id=info:doi/10.1002%2Frcm.7060 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-17 N1 - Date created - 2014-11-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/rcm.7060 ER - TY - JOUR T1 - Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type. AN - 1637567786; 25502671 AB - Here we report the genome sequence of a Clostridium botulinum strain IBCA10-7060 producing botulinum neurotoxin serotype B and a new toxin serotype. Multilocus sequence typing analysis revealed that this strain belongs to a new sequence type, and whole-genome single nucleotide polymorphism analysis showed that this strain clustered with strains in lineage 2 from group I. Copyright © 2014 Gonzalez-Escalona et al. JF - Genome announcements AU - Gonzalez-Escalona, Narjol AU - Thirunavukkarasu, Nagarajan AU - Singh, Ajay AU - Toro, Magaly AU - Brown, Eric W AU - Zink, Donald AU - Rummel, Andreas AU - Sharma, Shashi K AD - Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA. ; Office of the Center Director, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA. ; Institut für Toxikologie, Medizinische Hochschule Hannover, Niedersachsen, Germany. ; Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA shashi.sharma@fda.hhs.gov. Y1 - 2014/12/11/ PY - 2014 DA - 2014 Dec 11 VL - 2 IS - 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1637567786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+announcements&rft.atitle=Draft+Genome+Sequence+of+Bivalent+Clostridium+botulinum+Strain+IBCA10-7060%2C+Encoding+Botulinum+Neurotoxin+B+and+a+New+FA+Mosaic+Type.&rft.au=Gonzalez-Escalona%2C+Narjol%3BThirunavukkarasu%2C+Nagarajan%3BSingh%2C+Ajay%3BToro%2C+Magaly%3BBrown%2C+Eric+W%3BZink%2C+Donald%3BRummel%2C+Andreas%3BSharma%2C+Shashi+K&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2014-12-11&rft.volume=2&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Genome+announcements&rft.issn=&rft_id=info:doi/10.1128%2FgenomeA.01275-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-16 N1 - Date created - 2014-12-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/genomeA.01275-14 ER - TY - JOUR T1 - Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the direct detection of 2-monochloropropanediol (2-MCPD) esters in edible oils. AN - 1629958067; 25383913 AB - A new analytical method has been developed and validated for the detection and quantification of 2-monochloropropanediol (2-MCPD) esters in edible oils. The target compounds are potentially carcinogenic contaminants formed during the processing of edible oils. As the 2-MCPD esters that occur most frequently in refined edible oils were not commercially available, standards were synthesized with identity and purity (95+%) confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and (1)H NMR. Target analytes are separated from edible oil matrices using a two-step solid-phase extraction (SPE) procedure. The extracts are then analyzed using LC-MS/MS with electrospray ionization (ESI). The method has been validated for 11 2-MCPD diesters and 3 2-MCPD monoesters in soybean oil, olive oil, and palm oil using an external calibration curve. The ranges of average recoveries and relative standard deviations (RSD) across the three oil matrices at three spiking concentrations are 79-106% (3-13% RSD) for the 2-MCPD diesters and 72-108% (4-17% RSD) for the 2-MCPD monoesters, with limits of quantitation at or below 30 ng/g for the diesters and 90 ng/g for the monoesters. JF - Journal of agricultural and food chemistry AU - MacMahon, Shaun AU - Ridge, Clark D AU - Begley, Timothy H AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States. Y1 - 2014/12/03/ PY - 2014 DA - 2014 Dec 03 SP - 11647 EP - 11656 VL - 62 IS - 48 KW - 2-monochloropropanediol KW - 0 KW - Carcinogens KW - Esters KW - Olive Oil KW - Plant Oils KW - palm oil KW - 5QUO05548Z KW - Soybean Oil KW - 8001-22-7 KW - Glycerol KW - PDC6A3C0OX KW - Index Medicus KW - 3-MCPD KW - processing contaminants KW - edible oils KW - LC-MS/MS KW - 3-monochloropropanediol KW - 2-MCPD KW - Food Contamination -- analysis KW - Carcinogens -- analysis KW - Solid Phase Extraction KW - Carcinogens -- isolation & purification KW - Esters -- analysis KW - Esters -- isolation & purification KW - Tandem Mass Spectrometry -- methods KW - Glycerol -- analogs & derivatives KW - Glycerol -- analysis KW - Chromatography, High Pressure Liquid -- methods KW - Plant Oils -- analysis KW - Soybean Oil -- analysis KW - Glycerol -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629958067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Liquid+chromatography-tandem+mass+spectrometry+%28LC-MS%2FMS%29+method+for+the+direct+detection+of+2-monochloropropanediol+%282-MCPD%29+esters+in+edible+oils.&rft.au=MacMahon%2C+Shaun%3BRidge%2C+Clark+D%3BBegley%2C+Timothy+H&rft.aulast=MacMahon&rft.aufirst=Shaun&rft.date=2014-12-03&rft.volume=62&rft.issue=48&rft.spage=11647&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Fjf503994m LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-27 N1 - Date created - 2014-12-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/jf503994m ER - TY - JOUR T1 - Enhancement of ICRP's Lung Deposition Model for Pathogenic Bioaerosols AN - 1673389000; PQ0001231763 AB - Terrorist attacks using pathogenic bioaerosols pose a significant public-health threat. Modeling the risk associated with such attacks is valuable from the standpoint of disaster preparedness. To attain greater flexibility in bioterrorism risk modeling, we have developed an open-source lung deposition code based on the International Committee for Radiological Protection (ICRP) Publication 66 (ICRP 1994). This article describes modifications to ICRP's lung deposition model to fit the bioaerosol context and discusses the impact of exposure from a few monodisperse pathogenic toxins such as botulinum toxin, influenza virus, and Bacillus anthracis to infants and adults. As most existing commercial lung deposition codes are not open-source, this code provides users a platform template that can be modified to meet their needs. JF - Aerosol Science & Technology AU - Guha, Suvajyoti AU - Hariharan, Prasanna AU - Myers, Matthew R AD - Division of Applied Mechanics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA Y1 - 2014/12/02/ PY - 2014 DA - 2014 Dec 02 SP - 1226 EP - 1235 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 48 IS - 12 SN - 0278-6826, 0278-6826 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Aerosols KW - Terrorism KW - Bioaerosols KW - Airborne microorganisms KW - Disasters KW - Bacillus anthracis KW - Bioterrorism KW - Toxins KW - Influenza KW - Pollutant deposition KW - Influenza virus KW - Lung KW - Emergency preparedness KW - Committees KW - Infants KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673389000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerosol+Science+%26+Technology&rft.atitle=Enhancement+of+ICRP%27s+Lung+Deposition+Model+for+Pathogenic+Bioaerosols&rft.au=Guha%2C+Suvajyoti%3BHariharan%2C+Prasanna%3BMyers%2C+Matthew+R&rft.aulast=Guha&rft.aufirst=Suvajyoti&rft.date=2014-12-02&rft.volume=48&rft.issue=12&rft.spage=1226&rft.isbn=&rft.btitle=&rft.title=Aerosol+Science+%26+Technology&rft.issn=02786826&rft_id=info:doi/10.1080%2F02786826.2014.975334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Bioaerosols; Disasters; Influenza; Pollutant deposition; Aerosols; Terrorism; Lung; Committees; Emergency preparedness; Airborne microorganisms; Bioterrorism; Toxins; Infants; Influenza virus; Bacillus anthracis DO - http://dx.doi.org/10.1080/02786826.2014.975334 ER - TY - JOUR T1 - Comparison of measured and self-reported anthropometric information among firefighters: implications and applications AN - 1654680096; 21188308 AB - This study evaluated the accuracy of self-reported body weight and height compared to measured values among firefighters and identified factors associated with reporting error. A total of 863 male and 88 female firefighters in four US regions participated in the study. The results showed that both men and women underestimated their body weight ( - 0.4 plus or minus 4.1, - 1.1 plus or minus 3.6 kg) and overestimated their height (29 plus or minus 18 , 17 plus or minus 16 mm). Women underestimated more than men on weight (p = 0.022) and men overestimated more than women on height (p < 0.001). Reporting errors on weight were increased with overweight status (p < 0.001) and were disproportionate among subgroups. About 27% men and 24% women had reporting errors on weight greater than plus or minus 2.2 kg, and 59% men and 28% women had reporting errors on height greater than 25 mm. Practitioner Summary: This study along with literature revealed that the self-reported approach is not a sustainable option for anthropometric surveys, even for gathering data from physically active professional groups, such as firefighters, who presumably are knowledgeable of their body dimensions. Self-reported anthropometric information is undependable in important population subgroups. JF - Ergonomics AU - Hsiao, Hongwei AU - Weaver, Darlene AU - Hsiao, James AU - Whitestone, Jennifer AU - Kau, Tsui-Ying AU - Whisler, Richard AU - Ferri, Robert AD - Division of Safety Research, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, USA Y1 - 2014/12/02/ PY - 2014 DA - 2014 Dec 02 SP - 1886 EP - 1897 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 57 IS - 12 SN - 0014-0139, 0014-0139 KW - Sustainability Science Abstracts; Health & Safety Science Abstracts KW - weight KW - height KW - self-reported KW - firefighter KW - anthropometry KW - obesity KW - Obesity KW - Body weight KW - Firefighter services KW - Sustainable development KW - Ergonomics KW - M3 1010:Issues in Sustainable Development KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654680096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Comparison+of+measured+and+self-reported+anthropometric+information+among+firefighters%3A+implications+and+applications&rft.au=Hsiao%2C+Hongwei%3BWeaver%2C+Darlene%3BHsiao%2C+James%3BWhitestone%2C+Jennifer%3BKau%2C+Tsui-Ying%3BWhisler%2C+Richard%3BFerri%2C+Robert&rft.aulast=Hsiao&rft.aufirst=Hongwei&rft.date=2014-12-02&rft.volume=57&rft.issue=12&rft.spage=1886&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140139.2014.952351 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Obesity; Body weight; Firefighter services; Sustainable development; Ergonomics DO - http://dx.doi.org/10.1080/00140139.2014.952351 ER - TY - JOUR T1 - Deciphering miRNA transcription factor feed-forward loops to identify drug repurposing candidates for cystic fibrosis AN - 1642618664; 21178582 AB - Cystic fibrosis (CF) is a fatal genetic disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that primarily affects the lungs and the digestive system, and the current drug treatment is mainly able to alleviate symptoms. To improve disease management for CF, we considered the repurposing of approved drugs and hypothesized that specific microRNA (miRNA) transcription factors (TF) gene networks can be used to generate feed-forward loops (FFLs), thus providing treatment opportunities on the basis of disease specific FFLs. Comprehensive database searches revealed significantly enriched TFs and miRNAs in CF and CFTR gene networks. The target genes were validated using ChIPBase and by employing a consensus approach of diverse algorithms to predict miRNA gene targets. STRING analysis confirmed protein-protein interactions (PPIs) among network partners and motif searches defined composite FFLs. Using information extracted from SM2miR and Pharmaco-miR, an in silico drug repurposing pipeline was established based on the regulation of miRNA/TFs in CF/CFTR networks. In human airway epithelium, a total of 15 composite FFLs were constructed based on CFTR specific miRNA/TF gene networks. Importantly, nine of them were confirmed in patient samples and CF epithelial cells lines, and STRING PPI analysis provided evidence that the targets interacted with each other. Functional analysis revealed that ubiquitin-mediated proteolysis and protein processing in the endoplasmic reticulum dominate the composite FFLs, whose major functions are folding, sorting, and degradation. Given that the mutated CFTR gene disrupts the function of the chloride channel, the constructed FFLs address mechanistic aspects of the disease and, among 48 repurposing drug candidates, 26 were confirmed with literature reports and/or existing clinical trials relevant to the treatment of CF patients. The construction of FFLs identified promising drug repurposing candidates for CF and the developed strategy may be applied to other diseases as well. The online version of this article (doi:10.1186/s13073-014-0094-2) contains supplementary material, which is available to authorized users. JF - Genome Medicine AU - Liu, Zhichao AU - Borlak, Juergen AU - Tong, Weida AD - label/>Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 USA Y1 - 2014/12/02/ PY - 2014 DA - 2014 Dec 02 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 6 IS - 12 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Proteolysis KW - Epithelial cells KW - miRNA KW - Algorithms KW - Chloride channels KW - Cystic fibrosis transmembrane conductance regulator KW - Drug development KW - Clinical trials KW - Computer programs KW - Endoplasmic reticulum KW - Protein folding KW - Lung KW - Transcription factors KW - Epithelium KW - Cystic fibrosis KW - Drugs KW - Mutation KW - Internet KW - Respiratory tract KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642618664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+Medicine&rft.atitle=Deciphering+miRNA+transcription+factor+feed-forward+loops+to+identify+drug+repurposing+candidates+for+cystic+fibrosis&rft.au=Liu%2C+Zhichao%3BBorlak%2C+Juergen%3BTong%2C+Weida&rft.aulast=Liu&rft.aufirst=Zhichao&rft.date=2014-12-02&rft.volume=6&rft.issue=12&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Genome+Medicine&rft.issn=1756-994X&rft_id=info:doi/10.1186%2Fs13073-014-0094-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-01-21 N1 - SubjectsTermNotLitGenreText - Proteolysis; Epithelial cells; miRNA; Algorithms; Cystic fibrosis transmembrane conductance regulator; Chloride channels; Drug development; Clinical trials; Endoplasmic reticulum; Computer programs; Protein folding; Lung; Transcription factors; Epithelium; Mutation; Drugs; Cystic fibrosis; Internet; Respiratory tract DO - http://dx.doi.org/10.1186/s13073-014-0094-2 ER - TY - JOUR T1 - Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity AN - 1868338948; PQ0004058185 AB - Aging is linked to decrease of the body cell use of growth hormone (GH) and thyroxine, whereas the decrease is via "death hormones" inhibition? This study proposes different viewpoints. Since interleukin 17 receptor C (IL17RC) is highly expressed in tissues from age-related macular degeneration (AMD) patients, IL17RC signaling pathways are explored to evaluate Wnts/vascular endothelial growth factor (VEGF) expression and complement activity, which are pathological factors in AMD. IL17RC overexpression or VEGF treatment was performed in two cell lines for up to two-day. Real-time Quantitative PCR, confocal microscopy, immune-blot, MTT assay, etc. measured downstream effects. IL17RC overexpression increases Wnts and VEGF that forms complexes with Wnt-signaling components. VEGF or the Wnt-signaling components interacting with C3 suggests alternative complement pathway activation. Moreover, IL17RC-overexpressed cells or VEGF-treated cells for two-day, which is overstimulation, increase PI3K/Akt/GSK3 insensitivity and GSK3 activity, and decrease growth/survival. High GSK3 activity associates with many chronic diseases including type II Diabetes. This study shows high GSK3 activity can result from PI3K/Akt overstimulation. Type II Diabetes shows insulin resistance that the body cells decrease insulin use. Possessing little sensitive PI3K/Akt for receptor activation, cells after overstimulation, although live, hardly respond to PI3K/Akt activators including GH, thyroxine and insulin. These results suggest an alternative explanation of the body cells declining hormone use since various kinds of cell signaling-induced overstimulation events almost always linked to PI3K/Akt, increase with age. Playing pathological roles in senescence and diseases, overstimulation eventually generates health problems. JF - SpringerPlus AU - Liu, Xunxian AD - US Department of Health and Human Services, Intramural Research Program, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD, 20892, USA, xunxianl@mail.nih.gov Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1 EP - 12 PB - Springer Science & Business Media, Cham VL - 3 IS - 1 KW - Biotechnology and Bioengineering Abstracts KW - Vascular endothelial growth factor KW - Cell survival KW - Growth hormone KW - Wnt protein KW - Receptor mechanisms KW - Interleukin 1 KW - Hormones KW - Insulin KW - Diabetes mellitus KW - 1-Phosphatidylinositol 3-kinase KW - Interleukin 17 KW - Confocal microscopy KW - Complement activation KW - Thyroxine KW - AKT protein KW - Polymerase chain reaction KW - Senescence KW - Complement component C3 KW - Signal transduction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868338948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SpringerPlus&rft.atitle=Overstimulation+can+create+health+problems+due+to+increases+in+PI3K%2FAkt%2FGSK3+insensitivity+and+GSK3+activity&rft.au=Liu%2C+Xunxian&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2014-12-01&rft.volume=3&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=SpringerPlus&rft.issn=2193-1801&rft_id=info:doi/10.1186%2F2193-1801-3-356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Number of references - 43 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Cell survival; Vascular endothelial growth factor; Growth hormone; Wnt protein; Receptor mechanisms; Interleukin 1; Hormones; Insulin; Diabetes mellitus; 1-Phosphatidylinositol 3-kinase; Interleukin 17; Complement activation; Confocal microscopy; AKT protein; Thyroxine; Polymerase chain reaction; Complement component C3; Senescence; Signal transduction DO - http://dx.doi.org/10.1186/2193-1801-3-356 ER - TY - JOUR T1 - Meteorological influences on nitrogen dynamics of a coastal onsite wastewater treatment system AN - 1812219115; 2016-070054 AB - On-site wastewater treatment systems (OWTS) can contribute nitrogen (N) to coastal waters. In coastal areas with shallow groundwater, OWTS are likely affected by meteorological events. However, the meteorological influences on temporal variability of N exports from OWTS are not well documented. Hydrogeological characterization and seasonal monitoring of wastewater and groundwater quality were conducted at a residence adjacent to the Pamlico River Estuary, North Carolina, during a 2-yr field study (October 2009-2011). Rainfall was elevated during the first study year, relative to the annual mean. In the second year, drought was followed by extreme precipitation from Hurricane Irene. Recent meteorological conditions influenced N speciation and concentrations in groundwater. Groundwater total dissolved nitrogen (TDN) beneath the OWTS drainfield was dominated by nitrate during the drought; during wetter periods, ammonium and organic N were common. Effective precipitation (precipitation [P] minus evapotranspiration [ET]) affected OWTS TDN exports because of its influence on groundwater recharge and discharge. Groundwater nitrate-N concentrations beneath the drainfield were typically higher than 10 mg/L when total biweekly precipitation was less than evapotranspiration (precipitation deficit: P 15 m downgradient of the drainfield. Although OWTS nitrate inputs caused elevated groundwater nitrate concentrations between the drainfield and the estuary, the majority of nitrate was attenuated via denitrification between the OWTS and 48 m to the estuary. However, DON originating from the OWTS was mobile and contributed to elevated TDN concentrations along the groundwater flowpath to the estuary. JF - Journal of Environmental Quality AU - O'Driscoll, M A AU - Humphrey, C P AU - Deal, N E AU - Lindbo, D L AU - Zarate-Bermudez, M A Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1873 EP - 1885 PB - American Society of Agronomy, [and] Crop Science Society of America, [and] Soil Science Society of America, Madison, WI VL - 43 IS - 6 SN - 0047-2425, 0047-2425 KW - water quality KW - waste water KW - halogens KW - preferential flow KW - drought KW - critical load KW - chloride ion KW - Pamlico Sound KW - nitrate ion KW - discharge KW - lysimeters KW - hydrology KW - monitoring KW - nitrous oxide KW - solutes KW - evapotranspiration KW - recharge KW - dissolved oxygen KW - coastal environment KW - seasonal variations KW - United States KW - aquifer vulnerability KW - climatic controls KW - shallow-water environment KW - phytoplankton KW - oxygen KW - ammonium ion KW - Southern Atlantic Coastal Plain KW - plankton KW - nitrogen KW - ground water KW - water treatment KW - estuarine environment KW - water pollution KW - coastal aquifers KW - Atlantic Coastal Plain KW - chlorine KW - concentration KW - drainage KW - pollution KW - resistivity KW - geochemical cycle KW - aquifers KW - nitrification KW - North Carolina KW - bacteria KW - shallow aquifers KW - Hurricane Irene KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812219115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Quality&rft.atitle=Meteorological+influences+on+nitrogen+dynamics+of+a+coastal+onsite+wastewater+treatment+system&rft.au=O%27Driscoll%2C+M+A%3BHumphrey%2C+C+P%3BDeal%2C+N+E%3BLindbo%2C+D+L%3BZarate-Bermudez%2C+M+A&rft.aulast=O%27Driscoll&rft.aufirst=M&rft.date=2014-12-01&rft.volume=43&rft.issue=6&rft.spage=1873&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Quality&rft.issn=00472425&rft_id=info:doi/10.2134%2Fjeq2014.05.0227 L2 - https://www.agronomy.org/publications/jeq LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - Number of references - 68 N1 - PubXState - WI N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2016-08-18 N1 - CODEN - JEVQAA N1 - SubjectsTermNotLitGenreText - ammonium ion; aquifer vulnerability; aquifers; Atlantic Coastal Plain; bacteria; chloride ion; chlorine; climatic controls; coastal aquifers; coastal environment; concentration; critical load; discharge; dissolved oxygen; drainage; drought; estuarine environment; evapotranspiration; geochemical cycle; ground water; halogens; Hurricane Irene; hydrology; lysimeters; monitoring; nitrate ion; nitrification; nitrogen; nitrous oxide; North Carolina; oxygen; Pamlico Sound; phytoplankton; plankton; pollution; preferential flow; recharge; resistivity; seasonal variations; shallow aquifers; shallow-water environment; solutes; Southern Atlantic Coastal Plain; United States; waste water; water pollution; water quality; water treatment DO - http://dx.doi.org/10.2134/jeq2014.05.0227 ER - TY - JOUR T1 - Review of Bayesian statistical analysis methods for cytogenetic radiation biodosimetry, with a practical example AN - 1808691752; PQ0003214462 AB - Classical methods of assessing the uncertainty associated with radiation doses estimated using cytogenetic techniques are now extremely well defined. However, several authors have suggested that a Bayesian approach to uncertainty estimation may be more suitable for cytogenetic data, which are inherently stochastic in nature. The Bayesian analysis framework focuses on identification of probability distributions (for yield of aberrations or estimated dose), which also means that uncertainty is an intrinsic part of the analysis, rather than an 'afterthought'. In this paper Bayesian, as well as some more advanced classical, data analysis methods for radiation cytogenetics are reviewed that have been proposed in the literature. A practical overview of Bayesian cytogenetic dose estimation is also presented, with worked examples from the literature. JF - Radiation Protection Dosimetry AU - Ainsbury, Elizabeth A AU - Vinnikov, Volodymyr A AU - Puig, Pedro AU - Higueras, Manuel AU - Maznyk, Nataliya A AU - Lloyd, David C AU - Rothkamm, Kai AD - Public Health England Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxon OX11 0RQ, UK, liz.ainsbury@phe.gov.uk Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 185 EP - 196 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 162 IS - 3 SN - 0144-8420, 0144-8420 KW - Toxicology Abstracts; Environment Abstracts KW - Data processing KW - Radiation KW - Bayesian analysis KW - Reviews KW - Dosimetry KW - Statistical analysis KW - Stochasticity KW - X 24300:Methods KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808691752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Review+of+Bayesian+statistical+analysis+methods+for+cytogenetic+radiation+biodosimetry%2C+with+a+practical+example&rft.au=Ainsbury%2C+Elizabeth+A%3BVinnikov%2C+Volodymyr+A%3BPuig%2C+Pedro%3BHigueras%2C+Manuel%3BMaznyk%2C+Nataliya+A%3BLloyd%2C+David+C%3BRothkamm%2C+Kai&rft.aulast=Ainsbury&rft.aufirst=Elizabeth&rft.date=2014-12-01&rft.volume=162&rft.issue=3&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fnct301 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Data processing; Radiation; Bayesian analysis; Reviews; Dosimetry; Statistical analysis; Stochasticity DO - http://dx.doi.org/10.1093/rpd/nct301 ER - TY - RPRT T1 - Child and Family Development Research. OPRE Report 2014-89 AN - 1773223127; ED558535 AB - This catalog provides short descriptions of major Division of Child and Family Development (DCFD) projects from Fiscal Year 2014. Multiple projects are described in the areas of child care, Head Start/Early Head Start, child welfare promotion, and the recognition of cultural diversity. An additional section features projects that fall into more than one of the aforementioned categories Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 23 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Preschool Education KW - Early Childhood Education KW - Measures (Individuals) KW - Employed Parents KW - Research Projects KW - Child Care KW - National Surveys KW - Child Welfare KW - Emotional Development KW - Family School Relationship KW - Child Development KW - Disadvantaged Youth KW - Social Development KW - Cultural Differences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773223127?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - Impacts of Social-Emotional Curricula on Three-Year-Olds: Exploratory Findings from the Head Start CARES Demonstration. Research Snapshot. OPRE Report 2014-78 AN - 1773213460; ED558516 AB - This report presents exploratory impact findings for 3-year-olds from the Head Start CARES demonstration, a large-scale randomized controlled trial implemented in Head Start centers for one academic year across the country. The study was designed primarily to test the effects of the enhancements on 4-year-olds, but it also provides an opportunity to explore their impacts on a limited number of outcomes for 3-year-olds who were in the classrooms that included both 3- and 4-year-olds. Key findings in the study include: (1) The enhancements improved teachers' social-emotional instruction and improved teacher reports of 3-year-olds' social behaviors and closeness with their teachers; (2) The positive impacts of the enhancements as a group seem to be driven primarily by The Incredible Years; and (3) As a group, the enhancements did not affect 3-year-olds' pre-academic skills, as reported by teachers. [For the full report, see ED558517.] AU - Hsueh, JoAnn AU - Lowenstein, Amy E. AU - Morris, Pamela AU - Mattera, Shira K. AU - Bangser, Michael Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 2 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Student Teacher Relationship Scale KW - Social Skills Rating System KW - Maslach Burnout Inventory KW - United States (Midwest) KW - United States (West) KW - United States (South) KW - ERIC, Resources in Education (RIE) KW - Preschool Education KW - Early Childhood Education KW - Mixed Age Grouping KW - Thinking Skills KW - Program Effectiveness KW - Teacher Student Relationship KW - Classroom Environment KW - Student Characteristics KW - Mathematics Skills KW - Teacher Competencies KW - Comparative Analysis KW - Academic Ability KW - At Risk Students KW - Knowledge Level KW - Statistical Analysis KW - Emergent Literacy KW - Disadvantaged Youth KW - Social Development KW - Preschool Children KW - Effect Size KW - Age Differences KW - Teaching Methods KW - Measures (Individuals) KW - Play KW - Teacher Characteristics KW - Language Skills KW - Reading Skills KW - Social Behavior KW - Experimental Groups KW - Behavior Problems KW - Emotional Development KW - Problem Solving KW - Burnout KW - Control Groups KW - Interpersonal Competence KW - Theories KW - Early Intervention KW - Likert Scales KW - Faculty Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773213460?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Stress-release seismic source for seismic velocity measurement in mines AN - 1769963318; 2016-018220 AB - Accurate seismic event locations are needed to delineate roles of mine geometry, stress and geologic structures in developing rockburst conditions. Accurate absolute locations are challenging in mine environments with rapid changes in seismic velocity due to sharp contrasts between individual layers and large time-dependent velocity gradients attending excavations. Periodic use of controlled seismic sources can help constrain the velocity in this continually evolving propagation medium comprising the miners' workplace. With a view to constructing realistic velocity models in environments in which use of explosives is problematic, a seismic source was developed subject to the following design constraints: (i) suitable for use in highly disturbed zones surrounding mine openings, (ii) able to produce usable signals over km-scale distances in the frequency range of typical coal mine seismic events ( approximately 10-100 Hz), (iii) repeatable, (iv) portable, (v) non-disruptive to mining operations, and (vi) safe for use in potentially explosive gaseous environments. Designs of the compressed load column seismic source (CLCSS), which generates a stress, or load, drop normal to the surface of mine openings, and the fiber-optic based source-initiation timer are presented. Tests were conducted in a coal mine at a depth of 500 m (1700 ft) and signals were recorded on the surface with a 72-ch (14 Hz) exploration seismograph for load drops of 150-470 kN (16-48 tons). Signal-to-noise ratios of unfiltered signals ranged from approximately 200 immediately above the source (500 m (1700 ft)) to approximately 8 at the farthest extent of the array (slant distance of approximately 800 m (2600 ft)), suggesting the potential for use over longer range. Results are compared with signals produced by weight drop and sledge hammer sources, indicating the superior waveform quality for first-arrival measurements with the CLCSS seismic source. JF - American Geophysical Union Fall Meeting AU - Swanson, P L AU - Clark, C AU - Richardson, J AU - Martin, L AU - Zahl, E AU - Etter, A AU - Anonymous Y1 - 2014/12// PY - 2014 DA - December 2014 SP - Abstract S23C EP - 4508 PB - American Geophysical Union, Washington, DC VL - 2014 KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1769963318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=Stress-release+seismic+source+for+seismic+velocity+measurement+in+mines&rft.au=Swanson%2C+P+L%3BClark%2C+C%3BRichardson%2C+J%3BMartin%2C+L%3BZahl%2C+E%3BEtter%2C+A%3BAnonymous&rft.aulast=Swanson&rft.aufirst=P&rft.date=2014-12-01&rft.volume=2014&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2014 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-03-03 N1 - CODEN - #07548 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY STUDIES OF COBALT METAL (CAS NO. 7440-48-4) IN F344/N RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES OF COBALT METAL IN F344/NTac RATS AND B6C3F1/N MICE (INHALATION STUDIES) AN - 1732068371 AB - Cobalt metal is used in the production of alloys, in nuclear medicine, and as a catalyst in organic reactions. Exposure to cobalt metal dust occurs in a variety of metalworking occupations. We exposed groups of 50 male and female rats and mice to atmospheres containing aerosols of 1.25, 2.5, or 5 mg of cobalt metal particles per cubic meter of air. Similar groups of animals exposed to clean air in the same type of inhalation chambers served as the control groups. Animals were exposed 6 hours per day, 5 days per week for 2 years. Tissues from more than 40 sites were examined for every animal. All groups of male and female rats and mice exposed to cobalt metal had markedly increased incidences of lung neoplasms compared to the control groups. Other lesions of the respiratory tract included inflammation, fibrosis, and hyperplasia of the nose and lung in male and female rats and mice and lesions in the larynx and trachea in male and female mice. There were also increased incidences of pheochromocytomas of the adrenal medulla in male and female rats and tumors in the pancreatic islets in male rats. We conclude that exposure to cobalt metal particles caused lung neoplasms in male and female rats and mice. A spectrum of other nonneoplastic lesions in the respiratory tract of male and female rats and mice were caused by cobalt metal exposure. Cancers of the adrenal medulla in male and female rats and pancreatic islets in male rats were also attributed to cobalt metal exposure. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1 EP - 19,21-41,43-107,109-155,157-203,205-211,213-239,241-269,271-287,289-297 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Cobalt KW - Toxicology KW - Rodents KW - Carcinogens KW - Human exposure KW - Lung diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732068371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+COBALT+METAL+%28CAS+NO.+7440-48-4%29+IN+F344%2FN+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+COBALT+METAL+IN+F344%2FNTac+RATS+AND+B6C3F1%2FN+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-12-01&rft.volume=&rft.issue=581&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2014 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-11-10 ER - TY - RPRT T1 - FOREWORD AN - 1732068355 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732068355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-12-01&rft.volume=&rft.issue=581&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2014 N1 - Last updated - 2015-11-10 ER - TY - RPRT T1 - Table of contents AN - 1732068335 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732068335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-12-01&rft.volume=&rft.issue=581&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2014 N1 - Last updated - 2015-11-10 ER - TY - JOUR T1 - Comprehensive analysis of alterations in lipid and bile acid metabolism by carbon tetrachloride using integrated transcriptomics and metabolomics AN - 1709184752; 20926333 AB - Understanding mechanisms of liver injury can enable better preclinical testing and clinical management of patients. Carbon tetrachloride (CCl sub(4)), used extensively as a model hepatotoxicant, induces lipid perturbation and increases in plasma bile acids (BAs). An integrated transcriptomics and metabolomics approach was employed to investigate CCl sub(4)-induced alterations in lipid and BA metabolism. Sprague-Dawley rats were treated orally with corn oil, 50 (low dose, LD) or 2,000 mg CCl sub(4)/kg/d (high dose, HD). Animals were sacrificed at 6, 24 or 72 h. Terminal blood was collected for clinical chemistry and metabolomics analyses. Livers were harvested for histopathology, metabolomics and transcriptomics analyses. Both alanine aminotransferase (ALT) and aspartate aminotransferase (AST) increased in the treated groups with the greatest increases observed in the HD group at 24 and 72 h. Blood cholesterol and triglycerides (TGs) were significantly decreased in the HD group at both 24 and 72 h, and hepatocyte vacuolization was observed at these timepoints. Consistent with the clinical chemistry and histopathological data, metabolomics results showed that levels of total fatty acids increased in the liver but decreased in the blood in the HD group at the 24 and 72 h timepoints. This suggested that lipids accumulate in the liver. Primary BAs increased in both liver and blood, while secondary and conjugated BAs decreased in the liver and increased in the blood, which indicated that the BA conjugation pathway and that BA uptake by the liver were inhibited by CCl sub(4). Results from this study provide a better understanding of the mechanisms of CCl sub(4)-induced hepatotoxicity. JF - Metabolomics AU - Sun, Jinchun AU - Schmitt, Thomas AU - Schnackenberg, Laura K AU - Pence, Lisa AU - Ando, Yosuke AU - Greenhaw, James AU - Yang, Xi AU - Slavov, Svetoslav AU - Davis, Kelly AU - Salminen, William F AU - Mendrick, Donna L AU - Beger, Richard D AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA, Jinchun.Sun@fda.hhs.gov Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1293 EP - 1304 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 10 IS - 6 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Injuries KW - Hepatocytes KW - Aspartate aminotransferase KW - Lipids KW - Cholesterol KW - Alanine transaminase KW - hepatotoxicity KW - Lipid metabolism KW - Models KW - Oil KW - Blood KW - Carbon tetrachloride KW - Triglycerides KW - Bile acids KW - Fatty acids KW - Liver KW - Metabolism KW - metabolomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709184752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Comprehensive+analysis+of+alterations+in+lipid+and+bile+acid+metabolism+by+carbon+tetrachloride+using+integrated+transcriptomics+and+metabolomics&rft.au=Sun%2C+Jinchun%3BSchmitt%2C+Thomas%3BSchnackenberg%2C+Laura+K%3BPence%2C+Lisa%3BAndo%2C+Yosuke%3BGreenhaw%2C+James%3BYang%2C+Xi%3BSlavov%2C+Svetoslav%3BDavis%2C+Kelly%3BSalminen%2C+William+F%3BMendrick%2C+Donna+L%3BBeger%2C+Richard+D&rft.aulast=Sun&rft.aufirst=Jinchun&rft.date=2014-12-01&rft.volume=10&rft.issue=6&rft.spage=1293&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-014-0665-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 28 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Data processing; Injuries; Aspartate aminotransferase; Hepatocytes; Lipids; Cholesterol; Alanine transaminase; hepatotoxicity; Models; Lipid metabolism; Oil; Blood; Carbon tetrachloride; Triglycerides; Bile acids; Liver; Fatty acids; metabolomics; Metabolism DO - http://dx.doi.org/10.1007/s11306-014-0665-7 ER - TY - JOUR T1 - Trends in antibiotic prescribing in primary care for clinical syndromes subject to national recommendations to reduce antibiotic resistance, UK 1995-2011: analysis of a large database of primary care consultations AN - 1701493916; PQ0001800745 AB - Objectives To measure trends in antibiotic prescribing in UK primary care in relation to nationally recommended best practice. Patients and methods A descriptive study linking individual patient data on diagnosis and prescription in a large primary care database, covering 537 UK general practices during 1995-2011. Results The proportion of cough/cold episodes for which antibiotics were prescribed decreased from 47% in 1995 to 36% in 1999, before increasing to 51% in 2011. There was marked variation by primary care practice in 2011 [10th-90th percentile range (TNPR) 32%-65%]. Antibiotic prescribing for sore throats fell from 77% in 1995 to 62% in 1999 and then stayed broadly stable (TNPR 45%-78%). Where antibiotics were prescribed for sore throat, recommended antibiotics were used in 69% of cases in 2011 (64% in 1995). The use of recommended short-course trimethoprim for urinary tract infection (UTI) in women aged 16-74 years increased from 8% in 1995 to 50% in 2011; however, a quarter of practices prescribed short courses in less than or equal to 16% of episodes in 2011. For otitis media, 85% of prescriptions were for recommended antibiotics in 2011, increasing from 77% in 1995. All these changes in annual prescribing were highly statistically significant (P<0.001). Conclusions The implementation of national guidelines in UK primary care has had mixed success, with prescribing for coughs/colds, both in total and as a proportion of consultations, now being greater than before recommendations were made to reduce it. Extensive variation by practice suggests that there is significant scope to improve prescribing, particularly for coughs/colds and for UTIs. JF - Journal of Antimicrobial Chemotherapy AU - Hawker, Jeremy I AU - Smith, Sue AU - Smith, Gillian E AU - Morbey, Roger AU - Johnson, Alan P AU - Fleming, Douglas M AU - Shallcross, Laura AU - Hayward, Andrew C Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 3423 EP - 3430 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 69 IS - 12 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - antibiotic prescribing KW - primary care KW - surveillance trends KW - respiratory tract infections KW - otitis media KW - urinary tract infections KW - Databases KW - Trimethoprim KW - Data processing KW - Otitis media KW - Statistical analysis KW - Cough KW - Antibiotics KW - Pharyngitis KW - Urinary tract KW - Infection KW - Antibiotic resistance KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701493916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Trends+in+antibiotic+prescribing+in+primary+care+for+clinical+syndromes+subject+to+national+recommendations+to+reduce+antibiotic+resistance%2C+UK+1995-2011%3A+analysis+of+a+large+database+of+primary+care+consultations&rft.au=Hawker%2C+Jeremy+I%3BSmith%2C+Sue%3BSmith%2C+Gillian+E%3BMorbey%2C+Roger%3BJohnson%2C+Alan+P%3BFleming%2C+Douglas+M%3BShallcross%2C+Laura%3BHayward%2C+Andrew+C&rft.aulast=Hawker&rft.aufirst=Jeremy&rft.date=2014-12-01&rft.volume=69&rft.issue=12&rft.spage=3423&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdku291 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Databases; Trimethoprim; Data processing; Otitis media; Statistical analysis; Cough; Antibiotics; Urinary tract; Pharyngitis; Infection; Antibiotic resistance DO - http://dx.doi.org/10.1093/jac/dku291 ER - TY - JOUR T1 - External Quality Assessments for Microbiologic Diagnosis of Diphtheria in Europe AN - 1694975017; 21154729 AB - The European Diphtheria Surveillance Network (EDSN) ensures the reliable epidemiological and microbiologic assessment of disease prevalence in the European Union. Here, we describe a survey of current diagnostic techniques for diphtheria surveillance conducted across the European Union and report the results from three external quality assessment (EQA) schemes performed between 2010 and 2014. JF - Journal of Clinical Microbiology AU - Both, Leonard AU - Neal, Shona AU - Zoysa, Aruni De AU - Mann, Ginder AU - Czumbel, Ida AD - WHO Global Collaborating Centre for Reference and Research on Diphtheria and Streptococcal Infections, Public Health England (PHE), London, United Kingdom, androulla.efstratiou@phe.gov.uk. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 4381 EP - 4384 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 52 IS - 12 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Quality control KW - Diphtheria KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694975017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=External+Quality+Assessments+for+Microbiologic+Diagnosis+of+Diphtheria+in+Europe&rft.au=Both%2C+Leonard%3BNeal%2C+Shona%3BZoysa%2C+Aruni+De%3BMann%2C+Ginder%3BCzumbel%2C+Ida&rft.aulast=Both&rft.aufirst=Leonard&rft.date=2014-12-01&rft.volume=52&rft.issue=12&rft.spage=4381&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01776-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Number of references - 13 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Quality control; Diphtheria DO - http://dx.doi.org/10.1128/JCM.01776-14 ER - TY - JOUR T1 - Perceived HIV Status is a Key Determinant of Unprotected Anal Intercourse Within Partnerships of Men Who Have Sex With Men in Amsterdam AN - 1680149299; 201503008 AB - The practice of unprotected anal intercourse (UAI) involves at least two partners. We examined the associations between insertive or receptive UAI and perceived HIV seroconcordance and partnership type in self-perceived HIV-negative and self-perceived HIV-positive men who have sex with men (MSM). MSM (age >= 18 years) were recruited for a cross-sectional survey at the sexually transmitted infections clinic in Amsterdam, the Netherlands, in 2008-2009. Participants completed a questionnaire concerning partnerships in the preceding 6 months. Associations were quantified via multinomial logistic regression models using generalized estimating equations. The outcomes were 'no, or safe anal intercourse', 'insertive UAI', and 'receptive UAI'. We included 5,456 partnerships from 1,890 self-perceived HIV-negative men and 1,861 partnerships from 558 self-perceived HIV-positive men. Within the partnerships, perceived HIV status of the partner was an important determinant of UAI (p < 0.001). Among HIV-negative men, perceived HIV discordance was negatively associated with receptive UAI compared with no or safe UAI (OR 0.57; 95 % CI 0.36-0.92); when the partners were more familiar with each other, the risk of receptive UAI was increased relative to no or safe anal intercourse. Among HIV-positive men, perceived HIV discordance was negatively associated with insertive UAI (OR 0.05; 95 % CI 0.03-0.08). Within partnerships, perceived HIV status of the partner was one of the strongest determinants of UAI among self-perceived HIV-negative and HIV-positive MSM, and discordant serostatus was negatively associated with UAI. The findings suggest that serosorting is one of the main strategies when engaging in UAI. Adapted from the source document. JF - AIDS and Behavior AU - Matser, Amy AU - Heijman, Titia AU - Geskus, Ronald AU - Vries, Henry AU - Kretzschmar, Mirjam AU - Speksnijder, Arjen AU - Xiridou, Maria AU - Fennema, Han AU - Schim van der Loeff, Maarten AD - Department of Research, Cluster of Infectious Diseases, Public Health Service of Amsterdam, Postbox 2200, 1000 CE, Amsterdam, The Netherlands amatser@ggd.amsterdam.nl Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 2442 EP - 2456 PB - Springer, Dordrecht, The Netherlands VL - 18 IS - 12 SN - 1090-7165, 1090-7165 KW - Risk KW - Males KW - Acquired Immune Deficiency Syndrome KW - Venereal Diseases KW - Sexual Intercourse KW - Homosexuality KW - Netherlands KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680149299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Perceived+HIV+Status+is+a+Key+Determinant+of+Unprotected+Anal+Intercourse+Within+Partnerships+of+Men+Who+Have+Sex+With+Men+in+Amsterdam&rft.au=Matser%2C+Amy%3BHeijman%2C+Titia%3BGeskus%2C+Ronald%3BVries%2C+Henry%3BKretzschmar%2C+Mirjam%3BSpeksnijder%2C+Arjen%3BXiridou%2C+Maria%3BFennema%2C+Han%3BSchim+van+der+Loeff%2C+Maarten&rft.aulast=Matser&rft.aufirst=Amy&rft.date=2014-12-01&rft.volume=18&rft.issue=12&rft.spage=2442&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-014-0819-7 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-05-01 N1 - Number of references - 41 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Homosexuality; Males; Sexual Intercourse; Netherlands; Risk; Venereal Diseases DO - http://dx.doi.org/10.1007/s10461-014-0819-7 ER - TY - JOUR T1 - In Liberia, the End of the Ebola Epidemic will be the Beginning AN - 1673389001; PQ0001356794 JF - EcoHealth AU - Said, Maria AD - LCDR, United States Public Health Service, Washington, DC, USA, said.maria@gmail.com Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 459 EP - 460 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 11 IS - 4 SN - 1612-9202, 1612-9202 KW - Ecology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673389001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EcoHealth&rft.atitle=In+Liberia%2C+the+End+of+the+Ebola+Epidemic+will+be+the+Beginning&rft.au=Said%2C+Maria&rft.aulast=Said&rft.aufirst=Maria&rft.date=2014-12-01&rft.volume=11&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=EcoHealth&rft.issn=16129202&rft_id=info:doi/10.1007%2Fs10393-015-1017-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2015-11-16 DO - http://dx.doi.org/10.1007/s10393-015-1017-4 ER - TY - JOUR T1 - Regional use of the Australian Chronic Disease Dental Scheme AN - 1665158944 AB - Objective To determine whether a different number and type of services were provided in Australian regional areas under the Australian Government-funded Chronic Disease Dental Scheme (CDDS). Design Retrospective analysis of administrative payments data. Setting Australia. Participants Patients receiving dental services under the Medicare CDDS. Interventions The CDDS. Main outcome measures Number and type of services. Method CDDS service categories Australian Statistical Geography Standard (ASGS) regions were collected by the Australian Department of Human Services between 2008 and 2013 and compared by Australian Bureau of Statistics ASGS estimated resident regional 2011 population, and by employed number of dentists, dental specialists and dental prosthetists from the 2011 National Health Workforce Dataset. Results Number of services provided was greatest in major cities (79.0%), followed by inner regional (15.4%), outer regional (5.2%) and remote/very remote Australia (0.4%). Number of services per head of population decreased from 1.088 in major cities to 0.16 in remote/very remote areas. Number of services provided per dental practitioner showed minimal variation between major city (1672), inner (1777) and outer regional (1627) areas, but was lower in remote/very remote areas (641). Crown and bridge, periodontic, endodontic and removable prostheses per dental practitioner were most frequently supplied in the major cities, but restorative care and oral surgery were more frequently supplied in inner and outer regional areas. Conclusion The number of CDDS services provided declined with regional remoteness. There was a marked difference in the utilisation of the scheme between major cities and remote/very remote areas in both number and type of service levels. JF - The Australian Journal of Rural Health AU - Kraatz, Jennifer AU - Qin, Daiyo AU - Hoang, Ha AU - Godwin, Diana AU - Crocombe, Leonard A AD - Centre for Rural Health, School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia., Oral Health Services Tasmania, Tasmanian Department of Health and Human Services, Launceston, Tasmania, Australia. ; Centre for Rural Health, School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia. ; Centre for Rural Health, School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia., Australian Research Centre for Population Oral Health, School of Dentistry, University of Adelaide, Adelaide, South Australia, Australia., School of Dentistry, University of Western Australia, Perth, Western Australia, Australia. ; Centre for Rural Health, School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.; Oral Health Services Tasmania, Tasmanian Department of Health and Human Services, Launceston, Tasmania, Australia. Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 310 EP - 315 CY - Richmond PB - Wiley Subscription Services, Inc. VL - 22 IS - 6 SN - 1038-5282 KW - Medical Sciences KW - Chronic sickness KW - Cities KW - Dentists KW - Geography KW - Interventions KW - Labour force KW - Medicare KW - Occupational health and safety KW - Payments KW - Prosthetists KW - Regional variations KW - Remote areas KW - Service provision KW - Social services KW - Specialists KW - Surgery KW - Australia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665158944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Australian+Journal+of+Rural+Health&rft.atitle=Regional+use+of+the+Australian+Chronic+Disease+Dental+Scheme&rft.au=Kraatz%2C+Jennifer%3BQin%2C+Daiyo%3BHoang%2C+Ha%3BGodwin%2C+Diana%3BCrocombe%2C+Leonard+A&rft.aulast=Kraatz&rft.aufirst=Jennifer&rft.date=2014-12-01&rft.volume=22&rft.issue=6&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=The+Australian+Journal+of+Rural+Health&rft.issn=10385282&rft_id=info:doi/10.1111%2Fajr.12121 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - Australia DO - http://dx.doi.org/10.1111/ajr.12121 ER - TY - JOUR T1 - Facing the Recession: How Did Safety‐Net Hospitals Fare Financially Compared with Their Peers? AN - 1665156553 AB - 1,453 urban, nonfederal, general acute hospitals in 32 states with complete data. JF - Health Services Research AU - Reiter, Kristin L AU - Jiang, H Joanna AU - Wang, Jia AD - The University of North Carolina at Chapel Hill ; Agency for Healthcare Research and Quality. Center for Delivery, Organization, and Markets ; Data and Analytic Solutions, Inc. ; The University of North Carolina at Chapel Hill Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1747 EP - 1766 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 49 IS - 6 SN - 0017-9124 KW - Medical Sciences KW - Economic recession KW - Hospitals KW - Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665156553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Facing+the+Recession%3A+How+Did+Safety%E2%80%90Net+Hospitals+Fare+Financially+Compared+with+Their+Peers%3F&rft.au=Reiter%2C+Kristin+L%3BJiang%2C+H+Joanna%3BWang%2C+Jia&rft.aulast=Reiter&rft.aufirst=Kristin&rft.date=2014-12-01&rft.volume=49&rft.issue=6&rft.spage=1747&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12230 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.1111/1475-6773.12230 ER - TY - JOUR T1 - Physical and Mental Health Status of Iraqi Refugees Resettled in the United States AN - 1665156289 AB - We conducted a survey among Iraqi refugees resettled in the United States to assess their physical and mental health status and healthcare access and utilization following the initial 8-month, post-arrival period. We randomly selected Iraqi refugees: ≥18 years of age; living in the United States for 8–36 months; and residents of Michigan, California, Texas and Idaho. Participants completed a household questionnaire and mental health assessment. We distributed 366 surveys. Seventy-five percent of participants had health insurance at the time of the survey; 43 % reported delaying or not seeking care for a medical problem in the past year. Sixty percent of participants reported one chronic condition; 37 % reported ≥2 conditions. The prevalence of emotional distress, anxiety, and depression was approximately 50 % of participants; 31 % were at risk for post-traumatic stress disorder. Iraqi refugees in this evaluation reported a high prevalence of chronic conditions and mental health symptoms despite relatively high access to healthcare. It is important for resettlement partners to be aware of the distinctive health concerns of this population to best address needs within this community. JF - Journal of Immigrant and Minority Health AU - Taylor, Eboni M AU - Yanni, Emad A AU - Pezzi, Clelia AU - Guterbock, Michael AU - Rothney, Erin AU - Harton, Elizabeth AU - Montour, Jessica AU - Elias, Collin AU - Burke, Heather AD - Epidemic Intelligence Service, Immigrant, Refugee, and Migrant Health Branch, Division of Global Migration and Quarantine, US Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mail-stop E-03, Atlanta, GA, 30333, USA, United States Public Health Service, Washington, DC, USA ; Immigrant, Refugee, and Migrant Health Branch, Division of Global Migration and Quarantine, CDC, Atlanta, GA, USA ; Division of Global Migration and Quarantine, US Centers for Disease Control and Prevention, San Diego, CA, USA ; Division of Global Migration and Quarantine, US Centers for Disease Control and Prevention, Detroit, MI, USA ; Refugee Health Program, Texas Department of State Health Services, Austin, TX, USA ; Refugee Health Screening Program, Idaho Department of Health and Welfare, Boise, ID, USA ; Epidemic Intelligence Service, Immigrant, Refugee, and Migrant Health Branch, Division of Global Migration and Quarantine, US Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mail-stop E-03, Atlanta, GA, 30333, USA; United States Public Health Service, Washington, DC, USA Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1130 EP - 1137 CY - New York PB - Springer Science & Business Media VL - 16 IS - 6 SN - 1557-1912 KW - Medical Sciences KW - Anxiety-Depression KW - Conditions KW - Refugees KW - Resettlement KW - Risk assessment KW - Traumatic stress KW - At risk KW - Chronic sickness KW - Depression KW - Emotional distress KW - Health KW - Health care KW - Health insurance KW - Health problems KW - Health status KW - Insurance KW - Mental health KW - Mental illness KW - Posttraumatic stress disorder KW - Psychological distress KW - California KW - Idaho KW - Texas KW - United States--US KW - Michigan KW - Iraq UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665156289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Physical+and+Mental+Health+Status+of+Iraqi+Refugees+Resettled+in+the+United+States&rft.au=Taylor%2C+Eboni+M%3BYanni%2C+Emad+A%3BPezzi%2C+Clelia%3BGuterbock%2C+Michael%3BRothney%2C+Erin%3BHarton%2C+Elizabeth%3BMontour%2C+Jessica%3BElias%2C+Collin%3BBurke%2C+Heather&rft.aulast=Taylor&rft.aufirst=Eboni&rft.date=2014-12-01&rft.volume=16&rft.issue=6&rft.spage=1130&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-013-9893-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright Springer Science & Business Media Dec 2014 N1 - Date revised - 2015-01-09 N1 - Last updated - 2017-02-08 N1 - SubjectsTermNotLitGenreText - California; Idaho; Iraq; Michigan; Texas; United States--US DO - http://dx.doi.org/10.1007/s10903-013-9893-6 ER - TY - JOUR T1 - The use of Aspergillus niger cultures for biotransformation of terpenoids AN - 1664213480; PQ0001186556 AB - Aspergillus niger is a well-known fungus that has been used for many different biotransformations of organic compounds. The terpenoids include a large variety of natural hydrocarbons and their derivatives, mostly obtained from plant essential oils, but some obtained from animals or fungi. They may be acyclic or have one or more rings of various sizes, and they show a variety of biological activities that include antibacterial, antifungal, antiparasitic, antiviral, and anticancer activities. Terpenoids are classified as monoterpenoids (C sub(10)), sesquiterpenoids (C sub(15)), diterpenoids (C sub(20)), triterpenoids (C sub(30)), and others. This review summarizes experimental processes that use cultures of various A. niger strains to carry out stereoselective biochemical reactions in terpenoids, including related epoxides, lactones, N-phenylcarbamates, and saponins, to produce metabolites that may be useful as flavors and fragrances or as new experimental drug candidates. Cultures of A. niger that add hydroxyl, carbonyl, and other groups at specific positions or reduce double bonds have resulted in the production of valuable new compounds. JF - Process Biochemistry AU - Parshikov, Igor A AU - Sutherland, John B AD - Institute of Applied Mechanics, Russian Academy of Sciences, Moscow 119991, Russia, john.sutherland@fda.hhs.gov Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 2086 EP - 2100 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 49 IS - 12 SN - 1359-5113, 1359-5113 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Aspergillus niger KW - Biotransformation KW - Epoxides KW - Saponins KW - Terpenes KW - triterpenoids KW - Flavor KW - Hydrocarbons KW - Fungi KW - diterpenes KW - biotransformation KW - Metabolites KW - Drug development KW - lactones KW - sesquiterpenoids KW - Essential oils KW - monoterpenoids KW - Organic compounds KW - Fragrances KW - carbonyls KW - Antitumor activity KW - W 30950:Waste Treatment & Pollution Clean-up KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664213480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Process+Biochemistry&rft.atitle=The+use+of+Aspergillus+niger+cultures+for+biotransformation+of+terpenoids&rft.au=Parshikov%2C+Igor+A%3BSutherland%2C+John+B&rft.aulast=Parshikov&rft.aufirst=Igor&rft.date=2014-12-01&rft.volume=49&rft.issue=12&rft.spage=2086&rft.isbn=&rft.btitle=&rft.title=Process+Biochemistry&rft.issn=13595113&rft_id=info:doi/10.1016%2Fj.procbio.2014.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - triterpenoids; Epoxides; Flavor; Hydrocarbons; diterpenes; Fungi; biotransformation; Drug development; Metabolites; Saponins; lactones; sesquiterpenoids; monoterpenoids; Essential oils; Organic compounds; carbonyls; Fragrances; Antitumor activity; Aspergillus niger DO - http://dx.doi.org/10.1016/j.procbio.2014.09.005 ER - TY - JOUR T1 - Measures to quantify the abuse of prescription opioids: a review of data sources and metrics AN - 1660389145; 21123840 AB - Purpose The abuse and nonmedical use of prescription opioids and its subsequent consequences are an important public health concern. This phenomenon has paralleled the increase in the therapeutic use of opioids for pain management. There is thus a need to measure prescription opioid abuse to understand trends over time and to compare abuse of one product to another. The purpose of this review is to provide an overview of the strengths and weaknesses of frequently used numerators and denominators in "abuse ratios" (ARs). Methods For this review, we critically evaluated the various measures to quantify drug availability and the available data sources to measure prescription opioid abuse. Results There are currently no commonly adopted metrics for measuring either the prevalence of opioid abuse, or abuse relative to drug availability. Because the settings, manifestations, and severity of abuse can vary from one person to the next, no one measure of abuse, abuse-related outcome, or drug exposure is ideal. Each measure of abuse captures a specific facet of abuse, but not the whole spectrum. Reliable estimation of population-adjusted or utilization-adjusted rates of abuse can be accomplished with a prescription opioid AR. This metric estimates the prevalence of abuse in a given population or abuse relative to how much drug is available, and, in certain cases, can be used to compare abuse among various opioid drugs. AR measurements in the literature vary in the inclusion of specific measures of abuse and availability, and there is little consensus in the field regarding which measures allow for the most appropriate approximation of the extent of abuse, and for comparisons among opioids. Crude numbers of outcomes related to abuse (e.g., emergency department visits, treatment admissions, and overdoses) cannot be properly understood without context as these may overestimate or underestimate the true scope and severity of prescription opioid abuse. They can, however, serve as numerators in properly constructed ARs. The denominator of the AR provides the necessary context by accounting for populations at risk or drug availability (e.g., prescriptions or tablets dispensed, unique recipients of dispensed drug, total patient days of therapy, or kilograms sold), and each comes with its own set of assumptions to consider. Conclusions Moving forward, it is important that there be a common understanding in the scientific community regarding how to select appropriate measures to serve as numerators and denominators in AR calculations, and how to interpret the resultant findings. There is no single best measure of abuse for use as a numerator in an AR, and each must be chosen and interpreted in the context of what it measures. For public health considerations, one must always look at both absolute numbers and adjusted numbers. When conducting multiple analyses using different measures of exposure as denominators, differences in ARs are not unexpected, but one should explore why there are differences and assess the appropriateness of each of the denominators. Copyright copyright 2014 John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and Drug Safety AU - Secora, Alex M AU - Dormitzer, Catherine M AU - Staffa, Judy A AU - Dal Pan, Gerald J AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1227 EP - 1237 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 23 IS - 12 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts KW - Overdose KW - Data processing KW - Reviews KW - Tablets KW - Opioids KW - Pain KW - Drug abuse KW - Abuse KW - Public health KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660389145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Measures+to+quantify+the+abuse+of+prescription+opioids%3A+a+review+of+data+sources+and+metrics&rft.au=Secora%2C+Alex+M%3BDormitzer%2C+Catherine+M%3BStaffa%2C+Judy+A%3BDal+Pan%2C+Gerald+J&rft.aulast=Secora&rft.aufirst=Alex&rft.date=2014-12-01&rft.volume=23&rft.issue=12&rft.spage=1227&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.3711 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Overdose; Data processing; Reviews; Tablets; Pain; Opioids; Drug abuse; Abuse; Public health DO - http://dx.doi.org/10.1002/pds.3711 ER - TY - JOUR T1 - Respiratory manganese particle size, time-course and neurobehavioral outcomes in workers at a manganese alloy production plant AN - 1647011513; 21321512 AB - The progression of manganism with chronic exposure to airborne manganese (Mn) is not well understood. Here, we further investigate the findings on exposure and neurobehavioral outcomes of workers from a silico- and ferromanganese production plant and non-exposed workers from the same community in 1990 and 2004, using a variety of exposure metrics that distinguish particle size and origin within the range of respirable airborne exposures. Mn exposure matrices for large respirable particulate (Mn-LRP, dust) and small respirable particulate (Mn-SRP, fume), based on process origins, were used together with detailed work histories since 1973 (plant opening), to construct exposure metrics including burdens and cumulative burdens with various clearance half-lives. For three out of eight 1990 neurobehavioral tests analyzed with linear regression models, duration of Mn exposure was the best predictor: Luria-Nebraska Neuropsychological Battery - Motor Scale, Trail-Making B and Finger Tapping. The Luria-Nebraska Motor Scale had the strongest association (t 5.0, p <10-6). For outcomes on three other tests, the duration and Mn-SRP metrics were comparable: Trail Making Test A, Cancellation H and Stroop Color-Word Test (color/word subtest). Delayed Word Recall was best predicted by Mn-SRP (based on square root or truncated air-concentrations). The Word score on the Stroop Color-Word Test was the only outcome for which Mn-LRP was the leading predictor (t =-2.92, p =0.003), while performance on the WAIS-R Digit Span Test was not significantly predicted by any metric. For outcomes evaluated in both 1990 and 2004, a mixed-effect linear regression model was used to examine estimates of within-individual trends. Duration and Mn-SRP were associated with performance on the Luria-Nebraska Motor Scale, as well as with other outcomes that appeared to have both reversible and progressive features, including Trail Making A and B, Cancellation H and Delayed Word Recall. With the mixed-effect model, Digit Span exhibited a significant irreversible association with exposure duration (t =-2.34, p =0.021) and Mn-SRP (square root; t =-2.38, p =0.019) metrics. The strong prediction using duration of exposure is consistent with effective homeostatic regulation of tissue-level Mn in the observed exposure range of respirable Mn (<0.2mg/m3). JF - Neurotoxicology AU - Park, Robert M AU - Bouchard, Maryse F AU - Baldwin, Mary AU - Bowler, Rosemarie AU - Mergler, Donna AD - U.S. National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 276 EP - 284 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 45 SN - 0161-813X, 0161-813X KW - Health & Safety Science Abstracts; Environment Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Manganese KW - Burden KW - Fume KW - Half-life KW - Homeostasis KW - Prediction KW - Particle size KW - Historical account KW - Fumes KW - Motor task performance KW - Particulates KW - Dust KW - Finger KW - Color KW - Workers KW - Chronic exposure KW - Neurotoxicity KW - Plant communities KW - Regression analysis KW - Alloys KW - alloys KW - Occupational exposure KW - N3 11028:Neuropharmacology & toxicology KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647011513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Respiratory+manganese+particle+size%2C+time-course+and+neurobehavioral+outcomes+in+workers+at+a+manganese+alloy+production+plant&rft.au=Park%2C+Robert+M%3BBouchard%2C+Maryse+F%3BBaldwin%2C+Mary%3BBowler%2C+Rosemarie%3BMergler%2C+Donna&rft.aulast=Park&rft.aufirst=Robert&rft.date=2014-12-01&rft.volume=45&rft.issue=&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2014.03.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Particle size; Fumes; Motor task performance; Dust; Color; Finger; Workers; Chronic exposure; Regression analysis; Plant communities; alloys; Manganese; Occupational exposure; Prediction; Historical account; Neurotoxicity; Alloys; Particulates DO - http://dx.doi.org/10.1016/j.neuro.2014.03.015 ER - TY - JOUR T1 - Airborne manganese as dust vs. fume determining blood levels in workers at a manganese alloy production plant AN - 1647007534; 21321504 AB - The appropriate exposure metrics for characterizing manganese (Mn) exposure associated with neurobehavioral effects have not been established. Blood levels of Mn (B-Mn) provide a potentially important intermediate marker of Mn airborne exposures. Using data from a study of a population of silicon- and ferro-manganese alloy production workers employed between 1973 and 1991, B-Mn levels were modeled in relation to prior Mn exposure using detailed work histories and estimated respirable Mn concentrations from air-sampling records. Despite wide variation in exposure levels estimated for individual jobs, duration of employment (exposure) was itself a strong predictor of B-Mn levels and strongest when an 80-day half-life was applied to contributions over time (t =6.95, 7.44, respectively; p <10-5). Partitioning exposure concentrations based on process origin into two categories: (1) "large" respirable particulate (Mn-LRP) derived mainly from mechanically generated dust, and (2) "small" respirable particulate (Mn-SRP) primarily electric furnace condensation fume, revealed that B-Mn levels largely track the small, fume exposures. With a half-life of 65 days applied in a model with cumulative exposure terms for both Mn-LRP (t =-0.16, p =0.87) and Mn-SRP (t =6.45, p <10-5), the contribution of the large-size fraction contribution was negligible. Constructing metrics based on the square root of SRP exposure concentrations produced a better model fit (t =7.87 vs. 7.44, R 2 =0.2333 vs. 0.2157). In a model containing both duration (t =0.79, p =0.43) and (square root) fume (t =2.47, p =0.01) metrics, the duration term was a weak contributor. Furnace-derived, small respirable Mn particulate appears to be the primary contributor to B-Mn levels, with a dose-rate dependence in a population chronically exposed to Mn, with air-concentrations declining in recent years. These observations may reflect the presence of homeostatic control of Mn levels in the blood and other body tissues and be useful in assessing Mn exposures for evaluating neurotoxic effects. JF - Neurotoxicology AU - Park, Robert M AU - Baldwin, Mary AU - Bouchard, Maryse F AU - Mergler, Donna AD - U.S. National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 267 EP - 275 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 45 SN - 0161-813X, 0161-813X KW - Health & Safety Science Abstracts; Environment Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Manganese KW - Respiratory particle size KW - Half-life KW - Blood manganese KW - Manganese alloy production KW - Historical account KW - Particulates KW - Employment KW - Dust KW - Workers KW - Furnaces KW - Air sampling KW - Alloys KW - alloys KW - Occupational exposure KW - Fumes KW - Data processing KW - Population studies KW - Blood levels KW - Blood KW - Neurotoxicity KW - Condensation KW - N3 11028:Neuropharmacology & toxicology KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647007534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Airborne+manganese+as+dust+vs.+fume+determining+blood+levels+in+workers+at+a+manganese+alloy+production+plant&rft.au=Park%2C+Robert+M%3BBaldwin%2C+Mary%3BBouchard%2C+Maryse+F%3BMergler%2C+Donna&rft.aulast=Park&rft.aufirst=Robert&rft.date=2014-12-01&rft.volume=45&rft.issue=&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2014.03.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Workers; Blood; Data processing; Fumes; Neurotoxicity; Population studies; Condensation; alloys; Manganese; Dust; Occupational exposure; Blood levels; Historical account; Furnaces; Air sampling; Alloys; Employment; Particulates DO - http://dx.doi.org/10.1016/j.neuro.2014.03.006 ER - TY - JOUR T1 - Thymol treatment of bacteria prior to matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis aids in identifying certain bacteria at the subspecies level AN - 1642623519; 20912854 AB - RATIONALE The identification of bacteria based on mass spectra produced by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has become routine since its introduction in 1996. The major drawback is that bacterial patterns produced by MALDI are dependent on sample preparation prior to analysis. This results in poor reproducibility in identifying bacterial types and between laboratories. The need for a more broadly applicable and useful sample handling procedure is warranted. METHODS Thymol was added to the suspension solvent of bacteria prior to MALDI analysis. The suspension solvent consisted of ethanol, water and TFA. The bacterium was added to the thymol suspension solvent and heated. An aliquot of the bacterial suspension was mixed directly with the matrix solution at a 9:1 ratio, matrix/bacteria solution, respectively. The mixture was then placed on the MALDI plate and allowed to air dry before MALDI analysis. RESULTS The thymol method improved the quality of spectra and number of peaks when compared to other sample preparation procedures studied. The bacterium-identifying biomarkers assigned to four strains of E. coli were statistically 95% reproducible analyzed on three separate days. The thymol method successfully differentiated between the four E. coli strains. In addition, the thymol procedure could identify nine out of ten S. enterica serovars over a 3-day period and nine S. Typhimurium strains from the other ten serovars 90% of the time over the same period. CONCLUSIONS The thymol method can identify certain bacteria at the sub-species level and yield reproducible results over time. It improves the quality of spectra by increasing the number of peaks when compared to the other sample preparation methods assessed in this study. Published in 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Rapid Communications in Mass Spectrometry AU - Holland, Ricky D AU - Wilkes, Jon G AU - Cooper, Willie M AU - Alusta, Pierre AU - Williams, Anna AU - Pearce, Bruce AU - Beaudoin, Michael AU - Buzatu, Dan AD - Division of Systems Biology/Innovative Safety and Technologies Branch, USFDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 2617 EP - 2626 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 28 IS - 23 SN - 0951-4198, 0951-4198 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Escherichia coli KW - Solvents KW - thymol KW - Lasers KW - Salmonella typhimurium KW - Ionization KW - biomarkers KW - Mass spectroscopy KW - Ethanol KW - V 22360:AIDS and HIV KW - A 01300:Methods KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642623519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+Communications+in+Mass+Spectrometry&rft.atitle=Thymol+treatment+of+bacteria+prior+to+matrix-assisted+laser+desorption%2Fionization+time-of-flight+mass+spectrometric+analysis+aids+in+identifying+certain+bacteria+at+the+subspecies+level&rft.au=Holland%2C+Ricky+D%3BWilkes%2C+Jon+G%3BCooper%2C+Willie+M%3BAlusta%2C+Pierre%3BWilliams%2C+Anna%3BPearce%2C+Bruce%3BBeaudoin%2C+Michael%3BBuzatu%2C+Dan&rft.aulast=Holland&rft.aufirst=Ricky&rft.date=2014-12-01&rft.volume=28&rft.issue=23&rft.spage=2617&rft.isbn=&rft.btitle=&rft.title=Rapid+Communications+in+Mass+Spectrometry&rft.issn=09514198&rft_id=info:doi/10.1002%2Frcm.7060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Solvents; Lasers; thymol; biomarkers; Ionization; Mass spectroscopy; Ethanol; Escherichia coli; Salmonella typhimurium DO - http://dx.doi.org/10.1002/rcm.7060 ER - TY - JOUR T1 - Abundance of Vibrio cholerae, V. vulnificus, and V. parahaemolyticus in Oysters (Crassostrea virginica) and Clams (Mercenaria mercenaria) from Long Island Sound AN - 1642618644; 21154623 AB - Vibriosis is a leading cause of seafood-associated morbidity and mortality in the United States. Typically associated with consumption of raw or undercooked oysters, vibriosis associated with clam consumption is increasingly being reported. However, little is known about the prevalence of Vibrio spp. in clams. The objective of this study was to compare the levels of Vibrio cholerae, Vibrio vulnificus, and Vibrio parahaemolyticus in oysters and clams harvested concurrently from Long Island Sound (LIS). Most probable number (MPN)-real-time PCR methods were used for enumeration of total V. cholerae, V. vulnificus, V. parahaemolyticus, and pathogenic (tdh+ and/or trh+) V. parahaemolyticus. V. cholerae was detected in 8.8% and 3.3% of oyster (n = 68) and clam (n = 30) samples, with levels up to 1.48 and 0.48 log MPN/g in oysters and clams, respectively. V. vulnificus was detected in 97% and 90% of oyster and clam samples, with median levels of 0.97 and -0.08 log MPN/g, respectively. V. parahaemolyticus was detected in all samples, with median levels of 1.88 and 1.07 log MPN/g for oysters and clams, respectively. The differences between V. vulnificus and total and pathogenic V. parahaemolyticus levels in the two shellfish species were statistically significant (P < 0.001). These data indicate that V. vulnificus and total and pathogenic V. parahaemolyticus are more prevalent and are present at higher levels in oysters than in hard clams. Additionally, the data suggest differences in vibrio populations between shellfish harvested from different growing area waters within LIS. These results can be used to evaluate and refine illness mitigation strategies employed by risk managers and shellfish control authorities. JF - Applied and Environmental Microbiology AU - Jones, Jessica L AU - Luedeke, Catharina HM AU - Bowers, John C AU - DeRosia-Banick, Kristin AU - Carey, David H AU - Hastback, William AD - FDA, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama, USA, Jessica.Jones@fda.hhs.gov. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 7667 EP - 7672 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 80 IS - 24 SN - 0099-2240, 0099-2240 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Nucleotide sequence KW - Abundance KW - Statistical analysis KW - Morbidity KW - Islands KW - Vibrio vulnificus KW - Vibrio parahaemolyticus KW - Sound KW - Polymerase chain reaction KW - Mercenaria mercenaria KW - Marine KW - Mortality KW - Data processing KW - ANW, USA, Long Island Sound KW - Pathogenic bacteria KW - Shellfish fisheries KW - Vibriosis KW - Vibrio cholerae KW - USA KW - Most probable number KW - Microbiology KW - DNA KW - Marine molluscs KW - Crassostrea virginica KW - Mortality causes KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642618644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Abundance+of+Vibrio+cholerae%2C+V.+vulnificus%2C+and+V.+parahaemolyticus+in+Oysters+%28Crassostrea+virginica%29+and+Clams+%28Mercenaria+mercenaria%29+from+Long+Island+Sound&rft.au=Jones%2C+Jessica+L%3BLuedeke%2C+Catharina+HM%3BBowers%2C+John+C%3BDeRosia-Banick%2C+Kristin%3BCarey%2C+David+H%3BHastback%2C+William&rft.aulast=Jones&rft.aufirst=Jessica&rft.date=2014-12-01&rft.volume=80&rft.issue=24&rft.spage=7667&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02820-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Number of references - 36 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Vibriosis; Shellfish fisheries; Pathogenic bacteria; Nucleotide sequence; Microbiology; DNA; Polymerase chain reaction; Marine molluscs; Mortality causes; Mortality; Most probable number; Data processing; Islands; Abundance; Statistical analysis; Sound; Morbidity; Vibrio cholerae; Vibrio vulnificus; Vibrio parahaemolyticus; Crassostrea virginica; Mercenaria mercenaria; USA; ANW, USA, Long Island Sound; Marine DO - http://dx.doi.org/10.1128/AEM.02820-14 ER - TY - JOUR T1 - Interleukin-4 receptor alpha overexpression in human bladder cancer correlates with the pathological grade and stage of the disease. AN - 1642609399; 25208941 AB - Previously, we have demonstrated that interleukin-4 receptor α (IL-4Rα) is overexpressed on a variety of human cancers and can serve as target for IL-4 immunotoxin comprised of IL-4 and a mutated Pseudomonas exotoxin. However, its expression and association with grade and clinical stage of bladder cancer has not been studied. IL-4Rα expression was examined in human bladder cancer cell lines, mouse xenografts, and biopsy specimens at mRNA and protein levels by real-time RT-PCR and IHC/ISH techniques. We also examined the effect of IL-4 on proliferation and invasion of bladder carcinoma cell lines. For tissue microarray (TMA) results, we analyzed the precision data using exact binomial proportion with exact two-sided P-values. We used Cochran-Armitage Statistics with exact two-sided P-values to examine the trend analysis of IL-4Rα over grade or stage of the bladder cancer specimens. The influence of age and gender covariates was also analyzed using multiple logistic regression models. IL-4Rα is overexpressed in five bladder cancer cell lines, while normal bladder and human umbilical vein cell lines (HUVEC) expressed at low levels. Two other chains of IL-4 receptor complex, IL-2RγC and IL-13Rα1, were absent or weakly expressed. IL-4 modestly inhibited the cell proliferation, but enhanced cell invasion of bladder cancer cell lines in a concentration-dependent manner. Bladder cancer xenografts in immunodeficient mice also maintained IL-4Rα overexpression in vivo. Analysis of tumor biopsy specimens in TMAs revealed significantly higher IL-4Rα immunostaining (≥ 2+) in Grade 2 (85%) and Grade 3 (97%) compared to Grade 1 tumors (0%) (P ≤ 0.0001). Similarly, 9% stage I tumors were positive for IL-4Rα (≥ 2+) compared to 84% stage II (P ≤ 0.0001) and 100% stages III-IV tumors (P ≤ 0.0001). IL-13Rα1 was also expressed in tumor tissues but at low levels and it did not show any correlation with the grade and stage of disease. However, the IL-2RγC was not expressed. Ten normal bladder specimens demonstrated ≤ 1+ staining for IL-4Rα and IL-13Rα1 and no staining for IL-2RγC. These results demonstrate that IL-4Rα is overexpressed in human bladder cancer, which correlates with advanced grade and stage of the disease. Thus, IL-4Rα may be a bladder tumor-associated protein and a prognostic biomarker. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. Cancer Medicine published by John Wiley & Sons Ltd. JF - Cancer medicine AU - Joshi, Bharat H AU - Leland, Pamela AU - Lababidi, Samir AU - Varrichio, Frederick AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapy, Center for Biologics Evaluation and Research, NIH Building 29B, Room 2E1229 Lincoln Drive, Bethesda, 20892, Maryland. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1615 EP - 1628 VL - 3 IS - 6 KW - IL4R protein, human KW - 0 KW - Interleukin-4 Receptor alpha Subunit KW - Index Medicus KW - IL-4Rα KW - grade and clinical stage KW - tumor aggressiveness KW - bladder cancer-associated protein KW - Biomarker KW - Real-Time Polymerase Chain Reaction KW - Heterografts KW - Animals KW - Neoplasm Staging KW - Humans KW - Aged KW - Cell Line, Tumor KW - Human Umbilical Vein Endothelial Cells KW - Mice KW - Mice, Nude KW - Tissue Array Analysis KW - Adult KW - Neoplasm Grading KW - Middle Aged KW - Immunohistochemistry KW - Female KW - Urinary Bladder Neoplasms -- pathology KW - Urinary Bladder Neoplasms -- genetics KW - Interleukin-4 Receptor alpha Subunit -- genetics KW - Urinary Bladder Neoplasms -- metabolism KW - Interleukin-4 Receptor alpha Subunit -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642609399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+medicine&rft.atitle=Interleukin-4+receptor+alpha+overexpression+in+human+bladder+cancer+correlates+with+the+pathological+grade+and+stage+of+the+disease.&rft.au=Joshi%2C+Bharat+H%3BLeland%2C+Pamela%3BLababidi%2C+Samir%3BVarrichio%2C+Frederick%3BPuri%2C+Raj+K&rft.aulast=Joshi&rft.aufirst=Bharat&rft.date=2014-12-01&rft.volume=3&rft.issue=6&rft.spage=1615&rft.isbn=&rft.btitle=&rft.title=Cancer+medicine&rft.issn=2045-7634&rft_id=info:doi/10.1002%2Fcam4.330 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-23 N1 - Date created - 2015-01-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Hematol. 1999 Jan;69(1):13-20 [10641437] J Neurooncol. 2003 Aug-Sep;64(1-2):125-37 [12952293] Cancer Res. 2000 Jun 1;60(11):2981-7 [10850446] Clin Cancer Res. 2000 Jun;6(6):2157-65 [10873064] J Immunol. 2001 Dec 1;167(11):6497-502 [11714817] Cancer Res. 2001 Nov 15;61(22):8058-61 [11719427] J Neurooncol. 2003 Oct;65(1):15-25 [14649882] Cancer Cell. 2004 Aug;6(2):111-6 [15324694] Cell. 1990 Aug 10;62(3):457-67 [2116236] Science. 1991 Nov 1;254(5032):713-6 [1948050] Cancer Res. 1992 Jan 15;52(2):275-9 [1728401] J Clin Invest. 1993 Jan;91(1):88-93 [8423237] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2774-8 [8464888] Int J Cancer. 1995 Nov 3;63(3):366-71 [7591233] Cell Immunol. 1996 Jul 10;171(1):80-6 [8660841] Clin Exp Immunol. 1996 Aug;105(2):344-52 [8706344] Mol Med. 1997 May;3(5):327-38 [9205948] Blood. 1998 May 15;91(10):3884-91 [9573026] J Immunol. 1998 Jun 15;160(12):5869-73 [9637498] Int J Cancer. 1998 Jul 3;77(1):7-12 [9639386] J Immunother. 1998 Nov;21(6):440-6 [9807739] J Exp Med. 1999 Mar 15;189(6):919-30 [10075975] Nat Med. 1999 Jul;5(7):817-22 [10395328] Br J Cancer. 2005 Mar 14;92(5):921-8 [15714203] Cancer. 2005 May 15;103(10):2132-42 [15830341] J Immunother. 2005 Jul-Aug;28(4):376-81 [16000956] Cancer Res. 2005 Sep 15;65(18):8388-96 [16166317] Cancer Res. 2007 Oct 15;67(20):9903-12 [17942922] Cell Stem Cell. 2007 Oct 11;1(4):389-402 [18371377] Cancer Res. 2008 Nov 1;68(21):8687-94 [18974110] Cancer Cell. 2009 Aug 4;16(2):91-102 [19647220] Cell Mol Immunol. 2009 Dec;6(6):415-22 [20003817] Carcinogenesis. 2010 Jun;31(6):1010-7 [20176658] J Leukoc Biol. 2010 Jun;87(6):1011-8 [20335310] Nucleic Acids Res. 2011 Jan;39(Database issue):D945-50 [20952405] J Exp Med. 2011 Mar 14;208(3):469-78 [21339327] Clin Cancer Res. 2011 May 1;17(9):2757-66 [21536546] Cancer. 2011 Nov 15;117(22):5234-44 [21523763] Clin Cancer Res. 2012 Mar 15;18(6):1568-77 [22261806] Genet Mol Res. 2013;12(2):1479-89 [23765955] J Immunol. 2014 Jan 1;192(1):523-32 [24277698] CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29 [24399786] Nature. 2014 Mar 20;507(7492):315-22 [24476821] Clin Cancer Res. 2014 Aug 15;20(16):4390-9 [24938524] Springer Semin Immunopathol. 1999;21(3):339-59 [10666777] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cam4.330 ER - TY - JOUR T1 - An intake prior for the Bayesian analysis of plutonium and uranium exposures in an epidemiology study. AN - 1639496978; 24191121 AB - In Bayesian inference, the initial knowledge regarding the value of a parameter, before additional data are considered, is represented as a prior probability distribution. This paper describes the derivation of a prior distribution of intake that was used for the Bayesian analysis of plutonium and uranium worker doses in a recent epidemiology study. The chosen distribution is log-normal with a geometric standard deviation of 6 and a median value that is derived for each worker based on the duration of the work history and the number of reported acute intakes. The median value is a function of the work history and a constant related to activity in air concentration, M, which is derived separately for uranium and plutonium. The value of M is based primarily on measurements of plutonium and uranium in air derived from historical personal air sampler (PAS) data. However, there is significant uncertainty on the value of M that results from paucity of PAS data and from extrapolating these measurements to actual intakes. This paper compares posterior and prior distributions of intake and investigates the sensitivity of the Bayesian analyses to the assumed value of M. It is found that varying M by a factor of 10 results in a much smaller factor of 2 variation in mean intake and lung dose for both plutonium and uranium. It is concluded that if a log-normal distribution is considered to adequately represent worker intakes, then the Bayesian posterior distribution of dose is relatively insensitive to the value assumed of M. © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Radiation protection dosimetry AU - Puncher, M AU - Birchall, A AU - Bull, R K AD - Department of Toxicology, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot OX11 0RQ, UK matthew.puncher@phe.gov.uk. ; Department of Toxicology, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot OX11 0RQ, UK. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 306 EP - 315 VL - 162 IS - 3 KW - Uranium KW - 4OC371KSTK KW - Plutonium KW - 53023GN24M KW - Index Medicus KW - Radiation Dosage KW - Computer Simulation KW - Epidemiologic Studies KW - Humans KW - Cohort Studies KW - Models, Statistical KW - Urinalysis KW - Models, Biological KW - Bayes Theorem KW - Uranium -- analysis KW - Plutonium -- analysis KW - Occupational Exposure -- analysis KW - Lung -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639496978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=An+intake+prior+for+the+Bayesian+analysis+of+plutonium+and+uranium+exposures+in+an+epidemiology+study.&rft.au=Puncher%2C+M%3BBirchall%2C+A%3BBull%2C+R+K&rft.aulast=Puncher&rft.aufirst=M&rft.date=2014-12-01&rft.volume=162&rft.issue=3&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=1742-3406&rft_id=info:doi/10.1093%2Frpd%2Fnct268 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-03 N1 - Date created - 2014-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/rpd/nct268 ER - TY - JOUR T1 - Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland AN - 1635026371; 21029934 AB - Purpose : Concerns regarding a possible link between bisphenol A (BPA) and breast cancer have been mounting, but studies in human populations are lacking. We evaluated the association between the major urinary BPA metabolite [BPA-glucuronide (BPA-G)] and postmenopausal breast cancer risk in a large population-based case-control study conducted in two cities in Poland (2000-2003); we further explored the association of BPA-G levels with known postmenopausal breast cancer risk factors in our control population. Methods: We analyzed creatinine-adjusted urinary BPA-G levels among 575 postmenopausal cases matched on age and study site to 575 controls without breast cancer using a recently developed assay. Odds ratios and 95 % confidence intervals were used to estimate the association between urinary BPA-G level and breast cancer using conditional logistic regression. Among controls, geometric mean BPA-G levels were compared across categories of breast cancer risk factors using linear regression models. Results: There was no indication that increased BPA-G was associated with postmenopausal breast cancer (p-trend = 0.59). Among controls, mean BPA-G was higher among women reporting extended use of menopausal hormones, a prior screening mammogram, and residence in Warsaw. Other comparisons across strata of postmenopausal breast cancer risk factors were not related to differences in BPA-G. Conclusions: Urinary BPA-G, measured at the time of diagnosis, is not linked to postmenopausal breast cancer. JF - Cancer Causes & Control AU - Trabert, Britton AU - Falk, Roni T AU - Figueroa, Jonine D AU - Graubard, Barry I AU - Garcia-Closas, Montserrat AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Fox, Stephen D AU - Brinton, Louise A AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 7E-228, Bethesda, MD, 20892-9774, USA, britton.trabert@nih.gov Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1587 EP - 1593 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 25 IS - 12 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Bisphenol A KW - Health risks KW - Cities KW - Age KW - Post-menopause KW - Urine KW - Poland KW - Human populations KW - Breast cancer KW - Metabolites KW - Hormones KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635026371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Urinary+bisphenol+A-glucuronide+and+postmenopausal+breast+cancer+in+Poland&rft.au=Trabert%2C+Britton%3BFalk%2C+Roni+T%3BFigueroa%2C+Jonine+D%3BGraubard%2C+Barry+I%3BGarcia-Closas%2C+Montserrat%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BFox%2C+Stephen+D%3BBrinton%2C+Louise+A&rft.aulast=Trabert&rft.aufirst=Britton&rft.date=2014-12-01&rft.volume=25&rft.issue=12&rft.spage=1587&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-014-0461-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Number of references - 27 N1 - Last updated - 2015-02-12 N1 - SubjectsTermNotLitGenreText - Bisphenol A; Cities; Health risks; Age; Urine; Post-menopause; Human populations; Breast cancer; Metabolites; Hormones; Poland DO - http://dx.doi.org/10.1007/s10552-014-0461-8 ER - TY - JOUR T1 - The effectiveness of insurer-supported safety and health engineering controls in reducing workers' compensation claims and costs AN - 1635017448; 21008497 AB - Background This study evaluated the effectiveness of a program in which a workers' compensation (WC) insurer provided matching funds to insured employers to implement safety/health engineering controls. Methods Pre- and post-intervention WC metrics were compiled for the employees designated as affected by the interventions within 468 employers for interventions occurring from 2003 to 2009. Poisson, two-part, and linear regression models with repeated measures were used to evaluate differences in pre- and post-data, controlling for time trends independent of the interventions. Results For affected employees, total WC claim frequency rates (both medical-only and lost-time claims) decreased 66%, lost-time WC claim frequency rates decreased 78%, WC paid cost per employee decreased 81%, and WC geometric mean paid claim cost decreased 30% post-intervention. Reductions varied by employer size, specific industry, and intervention type. Conclusions The insurer-supported safety/health engineering control program was effective in reducing WC claims and costs for affected employees. Am. J. Ind. Med. 57:1398-1412, 2014. copyright 2014 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Wurzelbacher, Steven J AU - Bertke, Stephen J AU - Lampl, Michael P AU - Bushnell, PTimothy AU - Meyers, Alysha R AU - Robins, David C AU - Al-Tarawneh, Ibraheem S AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies. Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1398 EP - 1412 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 12 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Workers' compensation KW - Funds KW - Safety engineering KW - Safety KW - Intervention KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635017448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=The+effectiveness+of+insurer-supported+safety+and+health+engineering+controls+in+reducing+workers%27+compensation+claims+and+costs&rft.au=Wurzelbacher%2C+Steven+J%3BBertke%2C+Stephen+J%3BLampl%2C+Michael+P%3BBushnell%2C+PTimothy%3BMeyers%2C+Alysha+R%3BRobins%2C+David+C%3BAl-Tarawneh%2C+Ibraheem+S&rft.aulast=Wurzelbacher&rft.aufirst=Steven&rft.date=2014-12-01&rft.volume=57&rft.issue=12&rft.spage=1398&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22372 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2015-01-07 N1 - SubjectsTermNotLitGenreText - Workers' compensation; Funds; Safety engineering; Safety; Intervention DO - http://dx.doi.org/10.1002/ajim.22372 ER - TY - JOUR T1 - Biomarkers of exposure among U.S. cigar smokers: an analysis of 1999-2012 National Health and Nutrition Examination Survey (NHANES) data. AN - 1634271594; 25380733 AB - Cigar consumption is increasing in the United States, but little information is available about exposure to toxic constituents from cigar smoking. We conducted a cross-sectional analysis of biomarkers of tobacco exposure among 25,522 participants from the National Health and Nutrition Examination Survey (NHANES, 1999-2012). The biomarkers analyzed were serum cotinine, urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), blood lead, blood cadmium, and urinary arsenic. We calculated geometric mean concentrations for each biomarker by tobacco use category and geometric mean ratios controlling for demographic factors. Cigar smokers had higher cotinine, NNAL, and lead concentrations than nontobacco users. The geometric mean concentration [95% confidence interval (CI)] of cotinine for primary cigar smokers (i.e., current cigar/never cigarette smokers) was 6.2 (4.2-9.2) ng/mL versus 0.045 (0.043-0.048) ng/mL for nontobacco users, and the NNAL concentration was 19.1 (10.6-34.3) pg/mg creatinine for primary cigar smokers versus 1.01 (0.95-1.07) pg/mg creatinine for nontobacco users. Secondary cigar smokers (i.e., current cigar/former cigarette smokers) and dual cigar/cigarette smokers had higher cadmium concentrations than nontobacco users. Cigar smoking was associated with significantly higher concentrations of cotinine, NNAL, cadmium, and lead, after adjusting for demographic factors. Secondary cigar smokers had significantly higher cotinine and NNAL concentrations than primary cigar smokers. The NNAL concentrations in daily cigar smokers were comparable with those in daily cigarette smokers. Cigar smokers have higher concentrations of several toxic and carcinogenic substances than nontobacco users. Our results are consistent with epidemiologic evidence demonstrating cigar smoking as a cause of disease and premature death. ©2014 American Association for Cancer Research. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Chen, Jiping AU - Kettermann, Anna AU - Rostron, Brian L AU - Day, Hannah R AD - Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, Maryland. jiping.chen@fda.hhs.gov. ; Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, Maryland. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 2906 EP - 2915 VL - 23 IS - 12 KW - Biomarkers KW - 0 KW - Carcinogens KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - United States KW - Cross-Sectional Studies KW - History, 21st Century KW - History, 20th Century KW - Humans KW - Nutrition Surveys KW - Middle Aged KW - Male KW - Female KW - Biomarkers -- analysis KW - Nicotine -- analysis KW - Smoking -- adverse effects KW - Carcinogens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1634271594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Biomarkers+of+exposure+among+U.S.+cigar+smokers%3A+an+analysis+of+1999-2012+National+Health+and+Nutrition+Examination+Survey+%28NHANES%29+data.&rft.au=Chen%2C+Jiping%3BKettermann%2C+Anna%3BRostron%2C+Brian+L%3BDay%2C+Hannah+R&rft.aulast=Chen&rft.aufirst=Jiping&rft.date=2014-12-01&rft.volume=23&rft.issue=12&rft.spage=2906&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-14-0849 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-11 N1 - Date created - 2014-12-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1055-9965.EPI-14-0849 ER - TY - JOUR T1 - Mitochondria, energetics, epigenetics, and cellular responses to stress. AN - 1629966890; 25127496 AB - Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP production but also through metabolites generated in the tricarboxylic acid cycle, as well as mitochondria-nuclear signaling related to mitochondria morphology, biogenesis, fission/fusion, mitophagy, apoptosis, and epigenetic regulation. We investigated the concept of bidirectional interactions between mitochondria and cellular pathways in response to environmental stress with a focus on epigenetic regulation, and we examined DNA repair and DDR pathways as examples of biological processes that respond to exogenous insults through changes in homeostasis and altered mitochondrial function. The National Institute of Environmental Health Sciences sponsored the Workshop on Mitochondria, Energetics, Epigenetics, Environment, and DNA Damage Response on 25-26 March 2013. Here, we summarize key points and ideas emerging from this meeting. A more comprehensive understanding of signaling mechanisms (cross-talk) between the mitochondria and nucleus is central to elucidating the integration of mitochondrial functions with other cellular response pathways in modulating the effects of environmental agents. Recent studies have highlighted the importance of mitochondrial functions in epigenetic regulation and DDR with environmental stress. Development and application of novel technologies, enhanced experimental models, and a systems-type research approach will help to discern how environmentally induced mitochondrial dysfunction affects key mechanistic pathways. Understanding mitochondria-cell signaling will provide insight into individual responses to environmental hazards, improving prediction of hazard and susceptibility to environmental stressors. JF - Environmental health perspectives AU - Shaughnessy, Daniel T AU - McAllister, Kimberly AU - Worth, Leroy AU - Haugen, Astrid C AU - Meyer, Joel N AU - Domann, Frederick E AU - Van Houten, Bennett AU - Mostoslavsky, Raul AU - Bultman, Scott J AU - Baccarelli, Andrea A AU - Begley, Thomas J AU - Sobol, Robert W AU - Hirschey, Matthew D AU - Ideker, Trey AU - Santos, Janine H AU - Copeland, William C AU - Tice, Raymond R AU - Balshaw, David M AU - Tyson, Frederick L AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1271 EP - 1278 VL - 122 IS - 12 KW - DNA, Mitochondrial KW - 0 KW - Environmental Pollutants KW - Index Medicus KW - DNA, Mitochondrial -- drug effects KW - DNA Damage KW - Humans KW - Genome, Mitochondrial KW - DNA, Mitochondrial -- genetics KW - Environmental Pollutants -- toxicity KW - Mitochondria -- drug effects KW - Environmental Exposure KW - Environmental Pollutants -- administration & dosage KW - Mitochondria -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629966890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Mitochondria%2C+energetics%2C+epigenetics%2C+and+cellular+responses+to+stress.&rft.au=Shaughnessy%2C+Daniel+T%3BMcAllister%2C+Kimberly%3BWorth%2C+Leroy%3BHaugen%2C+Astrid+C%3BMeyer%2C+Joel+N%3BDomann%2C+Frederick+E%3BVan+Houten%2C+Bennett%3BMostoslavsky%2C+Raul%3BBultman%2C+Scott+J%3BBaccarelli%2C+Andrea+A%3BBegley%2C+Thomas+J%3BSobol%2C+Robert+W%3BHirschey%2C+Matthew+D%3BIdeker%2C+Trey%3BSantos%2C+Janine+H%3BCopeland%2C+William+C%3BTice%2C+Raymond+R%3BBalshaw%2C+David+M%3BTyson%2C+Frederick+L&rft.aulast=Shaughnessy&rft.aufirst=Daniel&rft.date=2014-12-01&rft.volume=122&rft.issue=12&rft.spage=1271&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408418 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-13 N1 - Date created - 2014-12-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Science. 2009 May 22;324(5930):1076-80 [19461003] Free Radic Biol Med. 2009 Jul 15;47(2):115-27 [19362589] Cell. 2009 Jul 10;138(1):18-20 [19596230] Nature. 2009 Jul 30;460(7255):587-91 [19641587] Mitochondrion. 2010 Jan;10(1):12-31 [19796712] Mol Cancer Res. 2010 Jan;8(1):67-79 [20068071] Mutat Res. 2010 Apr 1;686(1-2):57-67 [20096707] Methods. 2010 Aug;51(4):416-25 [20188838] Methods. 2010 Aug;51(4):452-7 [20347038] Nat Rev Mol Cell Biol. 2010 Sep;11(9):621-32 [20683470] Environ Health. 2010;9:48 [20696069] Mitochondrion. 2011 Mar;11(2):237-45 [21047563] Cell. 2011 Mar 4;144(5):646-74 [21376230] Cell Metab. 2011 May 4;13(5):517-26 [21531334] Mol Cell. 2011 May 20;42(4):426-37 [21596309] PLoS Genet. 2011 Jun;7(6):e1002080 [21655080] Antioxid Redox Signal. 2011 Jul 15;15(2):551-89 [20919933] Mitochondrion. 2011 Sep;11(5):686-92 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Dev. 2008 Jun 15;22(12):1577-90 [18559474] Cancer Biol Ther. 2008 Aug;7(8):1182-90 [18458531] J Cell Physiol. 2009 Jan;218(1):58-65 [18767040] Am J Respir Crit Care Med. 2009 Apr 1;179(7):572-8 [19136372] Science. 2009 May 22;324(5930):1029-33 [19460998] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408418 ER - TY - JOUR T1 - Identification of potential biomarkers of P-glycoprotein substrate neurotoxicity in transgenic mice expressing the mutated canine ABCB1 gene. AN - 1628238421; 25419811 AB - To identify biomarkers of P-glycoprotein (P-gp) substrate neurotoxicity in transgenic mice expressing the mutant canine ABCB1 gene (ABCB1-1Δ). 8 ABCB1 knock-in and knock-out transgenic mice expressing the ABCB1-1Δ gene and 8 control mice expressing the wild-type canine ABCB1 gene (ABCB1-WT). Groups including 2 ABCB1-1Δ mutant mice and 2 ABCB1-WT mice were administered the P-gp substrates ivermectin (10 mg/kg, SC), doramectin (10 mg/kg, SC), moxidectin (10 mg/kg, PO), or digoxin (1.53 mg/kg, SC). A toxicogenomic approach based on DNA microarrays was used to examine whole-genome expression changes in mice administered P-gp substrates. Compared with control ABCB1-WT mice, ABCB1-1Δ mutant mice developed neurotoxic signs including ataxia, lethargy, and tremors similar to those reported for dogs with the ABCB1-1Δ mutation. Microarray analysis revealed that gene expression was altered in ABCB1-1Δ mutant mice, compared with findings for ABCB1-WT mice, following administration of the same P-gp substrates. Gene pathway analysis revealed that genes with a ≥ 2-fold gene expression change were associated with behavior and nervous system development and function. Moreover, 34 genes were altered in the ABCB1-1Δ mutant mice in all 4 drug treatment groups. These genes were also associated with behavior, which was identified as the top-ranked gene network. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Δ mutant mice following exposure to various P-gp substrates. Some genes appear to be potential biomarkers of P-gp substrate neurotoxicity that might be used to predict the safety of those drugs in dogs with the ABCB1-1Δ mutation. JF - American journal of veterinary research AU - Zhu, Min AU - Ming, Yi AU - Swaim, Heidi AU - Swain, Marla D AU - Myers, Michael J AU - Deaver, Christine AU - Wu, Xiaolin AU - Jones, Yolanda L AU - Yancy, Haile F AD - Office of Research, Center for Veterinary Medicine, US FDA, 8401 Muirkirk Rd, Laurel, MD 20708. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1104 EP - 1110 VL - 75 IS - 12 KW - Biomarkers KW - 0 KW - Cardiotonic Agents KW - Insecticides KW - Organic Anion Transporters KW - P-Glycoproteins KW - Digoxin KW - 73K4184T59 KW - Index Medicus KW - Genotype KW - Animals KW - Gene Expression Regulation -- physiology KW - Dogs KW - Mice KW - Substrate Specificity KW - Neurotoxicity Syndromes -- genetics KW - Mice, Transgenic KW - Mutation KW - Insecticides -- toxicity KW - Insecticides -- metabolism KW - Cardiotonic Agents -- metabolism KW - P-Glycoproteins -- genetics KW - Organic Anion Transporters -- genetics KW - Digoxin -- toxicity KW - Cardiotonic Agents -- toxicity KW - Digoxin -- metabolism KW - Organic Anion Transporters -- metabolism KW - P-Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1628238421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+veterinary+research&rft.atitle=Identification+of+potential+biomarkers+of+P-glycoprotein+substrate+neurotoxicity+in+transgenic+mice+expressing+the+mutated+canine+ABCB1+gene.&rft.au=Zhu%2C+Min%3BMing%2C+Yi%3BSwaim%2C+Heidi%3BSwain%2C+Marla+D%3BMyers%2C+Michael+J%3BDeaver%2C+Christine%3BWu%2C+Xiaolin%3BJones%2C+Yolanda+L%3BYancy%2C+Haile+F&rft.aulast=Zhu&rft.aufirst=Min&rft.date=2014-12-01&rft.volume=75&rft.issue=12&rft.spage=1104&rft.isbn=&rft.btitle=&rft.title=American+journal+of+veterinary+research&rft.issn=1943-5681&rft_id=info:doi/10.2460%2Fajvr.75.12.1104 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-21 N1 - Date created - 2014-11-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2460/ajvr.75.12.1104 ER - TY - JOUR T1 - Identification and genetic characterization of Clostridium botulinum serotype A strains from commercially pasteurized carrot juice AN - 1627976300; 20957734 AB - Clostridium botulinum is an important foodborne pathogen capable of forming heat resistant endospores and producing deadly botulinum neurotoxins (BoNTs). In 2006, C. botulinum was responsible for an international outbreak of botulism attributed to the consumption of commercially pasteurized carrot juice. The purpose of this study was to isolate and characterize strains of C. botulinum from the adulterated product. Carrot juice bottles retrieved from the manufacturing facility were analyzed for the presence of BoNT and BoNT-producing isolates using DIG-ELISA. Toxigenic isolates from the carrot juice were analyzed using pulsed-field gel electrophoresis (PFGE) and DNA microarray analysis to determine their genetic relatedness to the original outbreak strains CDC51348 and CDC51303. PFGE revealed that isolates CJ4-1 and CJ10-1 shared an identical pulsotype with strain CDC51303, whereas isolate CJ5-1 displayed a unique restriction banding pattern. DNA microarray analysis identified several phage related genes unique to strain CJ5-1, and Southern hybridization analysis of XhoI digested and nondigested DNA showed their chromosomal location, while a homolog to pCLI_A009 of plasmid pCLI of C. botulinum serotype Langeland F, was located on a small plasmid. The acquisition or loss of bacteriophages and other mobile genetic elements among C. botulinum strains has epidemiological and evolutionary implications. JF - Food Microbiology AU - Marshall, Kristin M AU - Nowaczyk, Louis II AU - Raphael, Brian H AU - Skinner, Guy E AU - Rukma Reddy, N AD - Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 6502 South Archer Road, Bedford Park, IL 60501, USA Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 149 EP - 155 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 44 SN - 0740-0020, 0740-0020 KW - Genetics Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clostridium botulinum DNA microarray KW - PFGE (pulsed-field gel electrophoresis) KW - Botulinum neurotoxin (BoNT) KW - Plasmids KW - Bacteriophage KW - Phages KW - Serotypes KW - Botulism KW - Food KW - Juices KW - Daucus KW - Clostridium botulinum KW - Pathogens KW - DNA microarrays KW - Hybridization analysis KW - Heat KW - Pulsed-field gel electrophoresis KW - Botulinum toxin KW - Evolution KW - G 07800:Plants and Algae KW - A 01330:Food Microbiology KW - J 02400:Human Diseases KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627976300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Identification+and+genetic+characterization+of+Clostridium+botulinum+serotype+A+strains+from+commercially+pasteurized+carrot+juice&rft.au=Marshall%2C+Kristin+M%3BNowaczyk%2C+Louis+II%3BRaphael%2C+Brian+H%3BSkinner%2C+Guy+E%3BRukma+Reddy%2C+N&rft.aulast=Marshall&rft.aufirst=Kristin&rft.date=2014-12-01&rft.volume=44&rft.issue=&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.05.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Phages; Serotypes; Botulism; Food; Juices; Pathogens; Plasmids; DNA microarrays; Hybridization analysis; Heat; Pulsed-field gel electrophoresis; Botulinum toxin; Evolution; Daucus; Clostridium botulinum DO - http://dx.doi.org/10.1016/j.fm.2014.05.009 ER - TY - JOUR T1 - Cross-sectional study of genital carcinogenic HPV infections in Paramaribo, Suriname: prevalence and determinants in an ethnically diverse population of women in a pre-vaccination era. AN - 1625347168; 24920666 AB - Cervical cancer is caused by carcinogenic human papillomavirus (HPV) infections. Prior to the introduction of HPV vaccination in Suriname, we performed a cross-sectional study to estimate the prevalence of and determinants for genital carcinogenic HPV infections. Women were recruited at a family planning (FP) clinic and a sexually transmitted infections (STI) clinic. Vaginal swabs were used for HPV genotyping by the SPF10 PCR-DEIA-LiPA25 system. Logistic regression was used to identify determinants for carcinogenic HPV infection. The prevalence of any HPV was 54.2% and of carcinogenic HPV was 27.9% among 813 women attending the FP clinic. Among the 188 women attending the STI clinic, the prevalence of any HPV (76.1%) and of carcinogenic HPV (40.4%) was significantly higher. HPV52 was the most prevalent genotype in both clinics. The prevalence of HPV16 and/or 18 was 6.4% in the FP clinic and 12.2% in the STI clinic. The following determinants were independently associated with carcinogenic HPV infection among women visiting the FP clinic: ≥2 recent partners (OR 1.53; 95% CI 1.13 to 2.06), Chlamydia trachomatis co-infection (OR 1.89; 95% CI 1.32 to 2.70), disassortative ethnic sexual mixing (OR 1.50; 95% CI 1.13 to 1.99) and ethnic group (OR 1.90; 95% CI 1.27 to 2.85 for Creole and OR 1.67; 95% CI 1.06 to 2.62 for mixed ethnicity, both compared with Hindustani). No independent determinants were found among women visiting the STI clinic. Carcinogenic HPV is highly prevalent among women in Suriname, and not equally distributed among ethnic groups. These data provide a baseline to assess possible shifts in the prevalence of HPV genotypes following vaccination. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Sexually transmitted infections AU - Geraets, Daan T AU - Grünberg, Antoon W AU - van der Helm, Jannie J AU - Schim van der Loeff, Maarten F AU - Quint, Koen D AU - Sabajo, Leslie O A AU - de Vries, Henry J C AD - DDL Diagnostic Laboratory, Rijswijk, The Netherlands. ; Department of Public Health, Ministry of Health, Paramaribo, Suriname. ; STI Outpatient Clinic, Public Health Service Amsterdam, Amsterdam, The Netherlands Department of Research, Public Health Service Amsterdam, Amsterdam, The Netherlands. ; Department of Research, Public Health Service Amsterdam, Amsterdam, The Netherlands Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. ; DDL Diagnostic Laboratory, Rijswijk, The Netherlands Department of Dermatology LUMC, University of Leiden, Leiden, The Netherlands. ; Dermatological Service, Ministry of Health, Paramaribo, Suriname. ; STI Outpatient Clinic, Public Health Service Amsterdam, Amsterdam, The Netherlands Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 627 EP - 633 VL - 90 IS - 8 KW - Index Medicus KW - HPV KW - Cervical Neoplasia KW - Epidemiology (Clinical) KW - Chlamydia Infection KW - Genotyping Techniques KW - Genotype KW - Young Adult KW - Cross-Sectional Studies KW - Ethnic Groups KW - Risk Factors KW - Humans KW - Adult KW - Suriname -- epidemiology KW - Female KW - Papillomavirus Infections -- epidemiology KW - Papillomaviridae -- classification KW - Papillomaviridae -- isolation & purification KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1625347168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+transmitted+infections&rft.atitle=Cross-sectional+study+of+genital+carcinogenic+HPV+infections+in+Paramaribo%2C+Suriname%3A+prevalence+and+determinants+in+an+ethnically+diverse+population+of+women+in+a+pre-vaccination+era.&rft.au=Geraets%2C+Daan+T%3BGr%C3%BCnberg%2C+Antoon+W%3Bvan+der+Helm%2C+Jannie+J%3BSchim+van+der+Loeff%2C+Maarten+F%3BQuint%2C+Koen+D%3BSabajo%2C+Leslie+O+A%3Bde+Vries%2C+Henry+J+C&rft.aulast=Geraets&rft.aufirst=Daan&rft.date=2014-12-01&rft.volume=90&rft.issue=8&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Sexually+transmitted+infections&rft.issn=1472-3263&rft_id=info:doi/10.1136%2Fsextrans-2013-051384 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-09 N1 - Date created - 2014-11-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/sextrans-2013-051384 ER - TY - JOUR T1 - Cigarette smoke extract-induced BEAS-2B cell apoptosis and anti-oxidative Nrf-2 up-regulation are mediated by ROS-stimulated p38 activation. AN - 1618154513; 25134437 AB - Cigarette smoke contains reactive oxygen (ROS) that can cause oxidative stress. It increases the number of apoptotic and necrotic lung cells and further induces the development of chronic airway disease. In this study, we investigated the effects of cigarette smoke extract (CSE) on apoptosis in human bronchial epithelial cells (BEAS-2B). CSE exposure induced ROS generation and p38 mitogen-activated protein kinase (MAPK) activation that are associated with the activation of apoptosis-regulating signal kinase 1 (ASK-1). N-acetylcysteine (a general antioxidant) attenuated the CSE-induced ASK-1 and p38 MAPK activation and cell apoptosis, suggesting a triggering role of ROS in ASK-1/p38 MAPK activation during apoptotic progression. In contrast, the inhibition and knockdown of p38 attenuated the expression of anti-oxidant master NF-E2-related factor 2 (Nrf-2) and CSE-induced apoptosis, suggesting that p38 MAPK modulates Nrf-2 expression and presumably prevents cell apoptosis. Taken together, the data presented in this manuscript demonstrate that the ROS-dependent ASK-1/p38 signaling cascade regulates CSE-induced BEAS-2B cell apoptosis. In addition, anti-oxidative Nrf-2 is also up-regulated by the ROS/p38 signaling cascade in this progression. JF - Toxicology mechanisms and methods AU - Lin, Xi-Xi AU - Yang, Xin-Fu AU - Jiang, Jun-Xia AU - Zhang, Shui-Juan AU - Guan, Yan AU - Liu, Ya-Nan AU - Sun, Yan-Hong AU - Xie, Qiang-Min AD - Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration of China, Medical College of Zhejiang University , Hangzhou , China and. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 575 EP - 583 VL - 24 IS - 8 KW - Antioxidants KW - 0 KW - Complex Mixtures KW - NF-E2-Related Factor 2 KW - NFE2L2 protein, human KW - Reactive Oxygen Species KW - Smoke KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase Kinase 5 KW - EC 2.7.11.25 KW - MAP3K5 protein, human KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Nrf-2 KW - Apoptosis KW - cigarette smoke extract KW - bronchial epithelial cell KW - p38 MAPK KW - oxidative stress KW - Reactive Oxygen Species -- metabolism KW - Reactive Oxygen Species -- agonists KW - MAP Kinase Signaling System -- drug effects KW - Antioxidant Response Elements -- drug effects KW - Gene Silencing KW - Humans KW - p38 Mitogen-Activated Protein Kinases -- genetics KW - MAP Kinase Kinase Kinase 5 -- metabolism KW - Acetylcysteine -- pharmacology KW - MAP Kinase Kinase Kinase 5 -- antagonists & inhibitors KW - Complex Mixtures -- toxicity KW - Tobacco Products KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Antioxidants -- pharmacology KW - p38 Mitogen-Activated Protein Kinases -- chemistry KW - Enzyme Activation -- drug effects KW - Complex Mixtures -- antagonists & inhibitors KW - MAP Kinase Kinase Kinase 5 -- chemistry KW - Cell Line KW - NF-E2-Related Factor 2 -- genetics KW - NF-E2-Related Factor 2 -- antagonists & inhibitors KW - Respiratory Mucosa -- drug effects KW - Smoking -- adverse effects KW - Bronchi -- enzymology KW - Bronchi -- drug effects KW - NF-E2-Related Factor 2 -- metabolism KW - Respiratory Mucosa -- metabolism KW - Respiratory Mucosa -- enzymology KW - Up-Regulation -- drug effects KW - Apoptosis -- drug effects KW - Gene Expression Regulation -- drug effects KW - NF-E2-Related Factor 2 -- agonists KW - Bronchi -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1618154513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=Cigarette+smoke+extract-induced+BEAS-2B+cell+apoptosis+and+anti-oxidative+Nrf-2+up-regulation+are+mediated+by+ROS-stimulated+p38+activation.&rft.au=Lin%2C+Xi-Xi%3BYang%2C+Xin-Fu%3BJiang%2C+Jun-Xia%3BZhang%2C+Shui-Juan%3BGuan%2C+Yan%3BLiu%2C+Ya-Nan%3BSun%2C+Yan-Hong%3BXie%2C+Qiang-Min&rft.aulast=Lin&rft.aufirst=Xi-Xi&rft.date=2014-12-01&rft.volume=24&rft.issue=8&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.3109%2F15376516.2014.956909 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-29 N1 - Date created - 2014-10-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/15376516.2014.956909 ER - TY - JOUR T1 - Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension. AN - 1566407387; 25224369 AB - Cerium oxide (CeO2) nanoparticles have been posited to exhibit potent anti-oxidant activity which may allow for the use of these materials in biomedical applications. Herein, we investigate whether CeO2 nanoparticle administration can diminish right ventricular (RV) hypertrophy following four weeks of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Male Sprague Dawley rats were randomly divided into three groups: control, MCT only (60 mg/kg), or MCT + CeO2 nanoparticle treatment (60 mg/kg; 0.1 mg/kg). Compared to the control group, the RV weight to body weight ratio was 45% and 22% higher in the MCT and MCT + CeO2 groups, respectively (p < 0.05). Doppler echocardiography demonstrated that CeO2 nanoparticle treatment attenuated monocrotaline-induced changes in pulmonary flow and RV wall thickness. Paralleling these changes in cardiac function, CeO2 nanoparticle treatment also diminished MCT-induced increases in right ventricular (RV) cardiomyocyte cross sectional area, β-myosin heavy chain, fibronectin expression, protein nitrosylation, protein carbonylation and cardiac superoxide levels. These changes with treatment were accompanied by a decrease in the ratio of Bax/Bcl2, diminished caspase-3 activation and reduction in serum inflammatory markers. Taken together, these data suggest that CeO2 nanoparticle administration may attenuate the hypertrophic response of the heart following PAH. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Biomaterials AU - Kolli, Madhukar B AU - Manne, Nandini D P K AU - Para, Radhakrishna AU - Nalabotu, Siva K AU - Nandyala, Geeta AU - Shokuhfar, Tolou AU - He, Kun AU - Hamlekhan, Azhang AU - Ma, Jane Y AU - Wehner, Paulette S AU - Dornon, Lucy AU - Arvapalli, Ravikumar AU - Rice, Kevin M AU - Blough, Eric R AD - Department of Pharmacology, Physiology and Toxicology, Marshall University, Joan C. Edwards School of Medicine, Huntington, WV, United States; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, United States. ; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, United States. ; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, United States. ; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, United States; School of Materials Science and Engineering, Shandong University, Ji'nan, China. ; Health Effects Laboratory Division, NIOSH, Morgantown, WV, United States. ; Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States. ; Department of Pharmacology, Physiology and Toxicology, Marshall University, Joan C. Edwards School of Medicine, Huntington, WV, United States; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, United States; Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States; Department of Pharmaceutical Sciences and Research, Marshall University, Huntington, WV, United States. Electronic address: blough@marshall.edu. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 9951 EP - 9962 VL - 35 IS - 37 KW - Antioxidants KW - 0 KW - Cerium KW - 30K4522N6T KW - ceric oxide KW - 619G5K328Y KW - Monocrotaline KW - 73077K8HYV KW - Index Medicus KW - Pulmonary arterial hypertension KW - Right ventricular hypertrophy KW - Cerium oxide nanoparticles KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Heart Ventricles -- drug effects KW - Male KW - Heart Ventricles -- pathology KW - Hypertrophy, Right Ventricular -- drug therapy KW - Hypertension, Pulmonary -- chemically induced KW - Hypertrophy, Right Ventricular -- etiology KW - Nanoparticles -- therapeutic use KW - Cerium -- therapeutic use KW - Antioxidants -- therapeutic use KW - Nanoparticles -- ultrastructure KW - Hypertrophy, Right Ventricular -- pathology KW - Hypertension, Pulmonary -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566407387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Cerium+oxide+nanoparticles+attenuate+monocrotaline+induced+right+ventricular+hypertrophy+following+pulmonary+arterial+hypertension.&rft.au=Kolli%2C+Madhukar+B%3BManne%2C+Nandini+D+P+K%3BPara%2C+Radhakrishna%3BNalabotu%2C+Siva+K%3BNandyala%2C+Geeta%3BShokuhfar%2C+Tolou%3BHe%2C+Kun%3BHamlekhan%2C+Azhang%3BMa%2C+Jane+Y%3BWehner%2C+Paulette+S%3BDornon%2C+Lucy%3BArvapalli%2C+Ravikumar%3BRice%2C+Kevin+M%3BBlough%2C+Eric+R&rft.aulast=Kolli&rft.aufirst=Madhukar&rft.date=2014-12-01&rft.volume=35&rft.issue=37&rft.spage=9951&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=1878-5905&rft_id=info:doi/10.1016%2Fj.biomaterials.2014.08.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-03 N1 - Date created - 2014-09-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Circ Res. 2002 Jun 14;90(11):1150-2 [12065316] Anticancer Res. 2009 Oct;29(10):3977-82 [19846939] Circ Res. 2003 Aug 8;93(3):230-7 [12842921] Curr Opin Cardiol. 2004 Nov;19(6):575-81 [15502501] Stain Technol. 1987 Jan;62(1):23-6 [2438817] Microvasc Res. 1989 Jul;38(1):57-80 [2503687] Adv Exp Med Biol. 1991;283:477-87 [1906225] Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6 [8170963] J Cell Biol. 1997 Dec 1;139(5):1281-92 [9382873] Genes Dev. 1999 Aug 1;13(15):1899-911 [10444588] Technol Cancer Res Treat. 2005 Dec;4(6):651-9 [16292885] Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H247-56 [19395549] J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S10-9 [19555853] Ann Clin Lab Sci. 2009 Fall;39(4):378-85 [19880766] Small. 2009 Dec;5(24):2848-56 [19802857] Clin Exp Pharmacol Physiol. 2010 Feb;37(2):150-5 [19566840] Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1038-47 [20061549] Chem Commun (Camb). 2010 Apr 28;46(16):2736-8 [20369166] Int J Cardiovasc Imaging. 2010 Jun;26(5):509-18 [20140524] Eur Respir J. 2010 Jun;35(6):1286-93 [19897557] Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1666-75 [20926758] J Pharmacol Exp Ther. 2011 Jan;336(1):56-63 [20947636] Int J Nanomedicine. 2011;6:143-9 [21289991] J Pharmacol Exp Ther. 2011 Jul;338(1):53-61 [21464334] Free Radic Biol Med. 2011 Sep 15;51(6):1155-63 [21704154] Chest. 2012 Jan;141(1):210-21 [22215829] Environ Toxicol. 2013 Feb;28(2):107-18 [21618676] Nanomedicine (Lond). 2013 Sep;8(9):1483-508 [23987111] Biomaterials. 2014 Jan;35(1):249-58 [24140045] Free Radic Biol Med. 2013 Dec;65:1417-26 [24140865] Free Radic Biol Med. 2013 Aug;61:473-501 [23583330] J Pharmacol Exp Ther. 2001 Aug;298(2):469-76 [11454907] Am J Respir Crit Care Med. 2006 May 1;173(9):1023-30 [16456139] J Physiol. 2006 Jul 1;574(Pt 1):95-112 [16690706] Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1775-89 [16987031] Circulation. 2006 Sep 26;114(13):1417-31 [17000921] Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2424-30 [16731643] Cardiovasc Res. 2007 Feb 1;73(3):549-59 [17207782] Circ Res. 2007 Mar 2;100(4):474-88 [17332438] Biomaterials. 2008 Jun;29(18):2705-9 [18395249] Nat Nanotechnol. 2006 Nov;1(2):142-50 [18654167] Herz. 2002 Nov;27(7):662-8 [12439637] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.biomaterials.2014.08.037 ER - TY - RPRT T1 - NATIONAL INSTITUTES OF HEALTH BETHESDA CAMPUS PROPOSED 2013 MASTER PLAN, MONTGOMERY COUNTY, MARYLAND. AN - 1722904697; 16330 AB - PURPOSE: The National Institutes of Health (NIH) is preparing a 20-year Master Plan for the NIH Bethesda Campus, which provides a planning framework for siting and development of facilities. The Master Plan is part of a broader long-term planning effort required by the Department of Health and Human Services (HHS). The NIH Bethesda campus is a 310-acre Federal Government facility located in Montgomery County, Maryland, in the Washington, D.C. metropolitan area. This environmental impact statement addresses baseline or existing conditions present on the campus in the year 2012/2013 and the conditions as proposed by the 2013 NIH Master Plan Alternatives. JF - EPA number: 140336, Final EIS, November 28, 2014 PY - 2014 KW - Urban and Social Programs KW - Buildings KW - Land Use KW - Parking KW - Research KW - Research Facilities KW - Employment KW - Waste Management KW - Sewers KW - Demolition KW - Soils KW - Water Quality KW - Water Resources KW - Site Planning KW - Maryland KW - Executive Order 13327, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722904697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2014-11-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CAMPUS+PROPOSED+2013+MASTER+PLAN%2C+MONTGOMERY+COUNTY%2C+MARYLAND.&rft.title=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CAMPUS+PROPOSED+2013+MASTER+PLAN%2C+MONTGOMERY+COUNTY%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland N1 - Date revised - 2015-10-01 N1 - SuppNotes - Final. Preparation date: November 28, 2014 N1 - Last updated - 2015-10-19 ER - TY - CPAPER T1 - In-Process Particle Size Analysis for Commercial Pharmaceutical Manufacturing T2 - 2014 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2014) AN - 1627964590; 6311148 JF - 2014 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2014) AU - Sun, Zhigang Y1 - 2014/11/16/ PY - 2014 DA - 2014 Nov 16 KW - Particle size KW - Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627964590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2014%29&rft.atitle=In-Process+Particle+Size+Analysis+for+Commercial+Pharmaceutical+Manufacturing&rft.au=Sun%2C+Zhigang&rft.aulast=Sun&rft.aufirst=Zhigang&rft.date=2014-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2014%29&rft.issn=&rft_id=info:doi/ L2 - https://aiche.confex.com/aiche/2014/webprogram/meeting2014-11-16.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-31 N1 - Last updated - 2014-11-26 ER - TY - CPAPER T1 - Applying PAT for Pharmaceutical Powder Blending Process: Challenges and Opportunities T2 - 2014 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2014) AN - 1627963828; 6311150 JF - 2014 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2014) AU - Wu, Huiquan AU - Khan, Mansoor Y1 - 2014/11/16/ PY - 2014 DA - 2014 Nov 16 KW - Powder KW - Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627963828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2014%29&rft.atitle=Applying+PAT+for+Pharmaceutical+Powder+Blending+Process%3A+Challenges+and+Opportunities&rft.au=Wu%2C+Huiquan%3BKhan%2C+Mansoor&rft.aulast=Wu&rft.aufirst=Huiquan&rft.date=2014-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2014%29&rft.issn=&rft_id=info:doi/ L2 - https://aiche.confex.com/aiche/2014/webprogram/meeting2014-11-16.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-31 N1 - Last updated - 2014-11-26 ER - TY - JOUR T1 - Temporal trends in mortality among people who use drugs compared with the general Dutch population differ by hepatitis C virus and HIV infection status AN - 1765976088; PQ0002559501 AB - Objectives: We aimed to identify temporal trends in all-cause and cause-specific mortality rates among people who use drugs (PWUD) compared with the general Dutch population and to determine whether mortality trends differed by hepatitis C virus (HCV)/HIV (co) infection status. Design: Longitudinal cohort study. Methods: Using data from the Amsterdam Cohort Studies among 1254 PWUD (1985-2012), all-cause and cause-specific standardized mortality ratios (SMRs) were calculated; SMRs were stratified by serological group (HCV/HIV-uninfected, HCV-monoinfected, and HCV/HIV-coinfected) and calendar period. Temporal trends were estimated using Poisson regression. Results: The overall all-cause SMR was 13.9 (95% confidence interval 12.6-15.3). The SMR significantly declined after 1996, especially due to a decline among women (P < 0.001). The highest SMR was observed among HCV/HIV-coinfected individuals during 1990-1996 (SMR 61.9, 95% confidence interval 50.4-76.0), which significantly declined after this period among women (P = 0.001). In contrast, SMR for HCV-monoinfected, and HCV/HIV-uninfected PWUD did not significantly change overtime. The SMR for non-natural deaths significantly declined (P= 0.007), whereas the SMR for HIV-related deaths was the highest during all calendar periods. Conclusions: We found evidence for declining all-cause mortality among PWUD compared with the general population rates. Those with HCV/HIV-coinfection showed the highest SMR. The decline in the SMR seems to be attributable to the decline in mortality among women. Mortality rates due to non-natural deaths came closer to those of the general population overtime. However, HIV-related deaths remain an important cause of mortality among PWUD when compared with the general Dutch population. This study reinforces the importance of harm-reduction interventions and HCV/HIV treatment to reduce mortality among PWUD. JF - AIDS AU - van Santen, Daniela K AU - van der Helm, Jannie J AU - Grady, Bart PX AU - de Vos, Anneke S AU - Kretzschmar, Mirjam EE AU - Stolte, Ineke G AU - Prins, Maria AD - Department of Research, Cluster Infectious Diseases, Public Health Service Amsterdam, Amsterdam, dvsanten@ggd.amsterdam.nl Y1 - 2014/11/13/ PY - 2014 DA - 2014 Nov 13 SP - 2589 EP - 2599 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 United States VL - 28 IS - 17 SN - 0269-9370, 0269-9370 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - causes of death KW - hepatitis C KW - HIV KW - people who use drugs KW - standardized mortality ratio KW - trends KW - Mortality KW - Acquired immune deficiency syndrome KW - Data processing KW - Intervention KW - Infection KW - ANE, Netherlands, Noord-Holland, Amsterdam KW - Hepatitis C virus KW - Human immunodeficiency virus KW - Standards KW - Hepatitis C KW - Drugs KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765976088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Temporal+trends+in+mortality+among+people+who+use+drugs+compared+with+the+general+Dutch+population+differ+by+hepatitis+C+virus+and+HIV+infection+status&rft.au=van+Santen%2C+Daniela+K%3Bvan+der+Helm%2C+Jannie+J%3BGrady%2C+Bart+PX%3Bde+Vos%2C+Anneke+S%3BKretzschmar%2C+Mirjam+EE%3BStolte%2C+Ineke+G%3BPrins%2C+Maria&rft.aulast=van+Santen&rft.aufirst=Daniela&rft.date=2014-11-13&rft.volume=28&rft.issue=17&rft.spage=2589&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0000000000000450 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Infection; Drugs; Acquired immune deficiency syndrome; Human immunodeficiency virus; Intervention; Standards; Hepatitis C; Hepatitis C virus; ANE, Netherlands, Noord-Holland, Amsterdam DO - http://dx.doi.org/10.1097/QAD.0000000000000450 ER - TY - JOUR T1 - Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver. AN - 1612286537; 25123088 AB - Tamoxifen is a non-steroidal anti-estrogenic drug widely used for the treatment and prevention of breast cancer in women; however, there is evidence that tamoxifen is hepatocarcinogenic in rats, but not in mice. Additionally, it has been reported that tamoxifen may cause non-alcoholic fatty liver disease (NAFLD) in humans and experimental animals. The goals of the present study were to (i) investigate the mechanisms of the resistance of mice to tamoxifen-induced hepatocarcinogenesis, and (ii) clarify effects of tamoxifen on NAFLD-associated liver injury. Feeding female WSB/EiJ mice a 420 p.p.m. tamoxifen-containing diet for 12 weeks resulted in an accumulation of tamoxifen-DNA adducts, (E)-α-(deoxyguanosin-N(2)-yl)-tamoxifen (dG-TAM) and (E)-α-(deoxyguanosin-N(2)-yl)-N-desmethyltamoxifen (dG-DesMeTAM), in the livers. The levels of hepatic dG-TAM and dG-DesMeTAM DNA adducts in tamoxifen-treated mice were 578 and 340 adducts/108 nucleotides, respectively, while the extent of global DNA and repetitive elements methylation and histone modifications did not differ from the values in control mice. Additionally, there was no biochemical or histopathological evidence of NAFLD-associated liver injury in mice treated with tamoxifen. A transcriptomic analysis of differentially expressed genes demonstrated that tamoxifen caused predominantly down-regulation of hepatic lipid metabolism genes accompanied by a distinct over-expression of the lipocalin 13 (Lcn13) and peroxisome proliferator receptor gamma (Pparγ), which may prevent the development of NAFLD. The results of the present study demonstrate that the resistance of mice to tamoxifen-induced liver carcinogenesis may be associated with its ability to induce genotoxic alterations only without affecting the cellular epigenome and an inability of tamoxifen to induce the development of NAFLD. Published by Elsevier Ireland Ltd. JF - Toxicology AU - de Conti, Aline AU - Tryndyak, Volodymyr AU - Churchwell, Mona I AU - Melnyk, Stepan AU - Latendresse, John R AU - Muskhelishvili, Levan AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA. ; Toxicologic Pathology Associates, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Electronic address: igor.pogribny@fda.hhs.gov. Y1 - 2014/11/05/ PY - 2014 DA - 2014 Nov 05 SP - 12 EP - 20 VL - 325 KW - DNA Adducts KW - 0 KW - Estrogen Antagonists KW - Histones KW - Tamoxifen KW - 094ZI81Y45 KW - Index Medicus KW - Gene expression KW - DNA adducts KW - Liver KW - Epigenetics KW - Mouse KW - Animals KW - Histones -- metabolism KW - DNA Methylation -- drug effects KW - Chromatin Assembly and Disassembly -- drug effects KW - Mice KW - Gene Expression Regulation -- drug effects KW - Time Factors KW - Species Specificity KW - Female KW - DNA Adducts -- metabolism KW - Risk Assessment KW - Tamoxifen -- toxicity KW - Estrogen Antagonists -- toxicity KW - Liver -- pathology KW - Liver Neoplasms -- metabolism KW - Cell Transformation, Neoplastic -- metabolism KW - Liver Neoplasms -- chemically induced KW - Liver -- metabolism KW - Gene Expression Profiling -- methods KW - Non-alcoholic Fatty Liver Disease -- genetics KW - Non-alcoholic Fatty Liver Disease -- metabolism KW - Liver -- drug effects KW - Non-alcoholic Fatty Liver Disease -- chemically induced KW - Epigenesis, Genetic -- drug effects KW - Cell Transformation, Neoplastic -- chemically induced KW - Cell Transformation, Neoplastic -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1612286537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Genotoxic%2C+epigenetic%2C+and+transcriptomic+effects+of+tamoxifen+in+mouse+liver.&rft.au=de+Conti%2C+Aline%3BTryndyak%2C+Volodymyr%3BChurchwell%2C+Mona+I%3BMelnyk%2C+Stepan%3BLatendresse%2C+John+R%3BMuskhelishvili%2C+Levan%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=de+Conti&rft.aufirst=Aline&rft.date=2014-11-05&rft.volume=325&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2014.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-18 N1 - Date created - 2014-10-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2014.08.004 ER - TY - JOUR T1 - Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma. AN - 1609309343; 25086301 AB - While conventional parameters used to detect hepatotoxicity in drug safety assessment studies are generally informative, the need remains for parameters that can detect the potential for hepatotoxicity at lower doses and/or at earlier time points. Previous work has shown that metabolite profiling (metabonomics/metabolomics) can detect signals of potential hepatotoxicity in rats treated with doxorubicin at doses that do not elicit hepatotoxicity as monitored with conventional parameters. The current study extended this observation to the question of whether such signals could be detected in rats treated with compounds that can elicit hepatotoxicity in humans (i.e., drug-induced liver injury, DILI) but have not been reported to do so in rats. Nine compounds were selected on the basis of their known DILI potential, with six other compounds chosen as negative for DILI potential. A database of rat plasma metabolite profiles, MetaMap(®)Tox (developed by metanomics GmbH and BASF SE) was used for both metabolite profiles and mode of action (MoA) metabolite signatures for a number of known toxicities. Eight of the nine compounds with DILI potential elicited metabolite profiles that matched with MoA patterns of various rat liver toxicities, including cholestasis, oxidative stress, acetaminophen-type toxicity and peroxisome proliferation. By contrast, only one of the six non-DILI compounds showed a weak match with rat liver toxicity. These results suggest that metabolite profiling may indeed have promise to detect signals of hepatotoxicity in rats treated with compounds having DILI potential. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology letters AU - Mattes, W AU - Davis, K AU - Fabian, E AU - Greenhaw, J AU - Herold, M AU - Looser, R AU - Mellert, W AU - Groeters, S AU - Marxfeld, H AU - Moeller, N AU - Montoya-Parra, G AU - Prokoudine, A AU - van Ravenzwaay, B AU - Strauss, V AU - Walk, T AU - Kamp, H AD - PharmPoint Consulting, 17014 Hersperger Ln, Poolesville, MD 20837, USA. ; Toxicologic Pathology Associates, Jefferson, AR, USA. ; BASF SE, Ludwigshafen, Germany. ; National Center for Toxicological Research, FDA, Jefferson, AR, USA. ; Metanomics GmbH, Berlin, Germany. ; Metanomics Health GmbH, Berlin, Germany. ; BASF SE, Ludwigshafen, Germany. Electronic address: bennard.ravenzwaay@basf.com. Y1 - 2014/11/04/ PY - 2014 DA - 2014 Nov 04 SP - 467 EP - 478 VL - 230 IS - 3 KW - Triazoles KW - 0 KW - Neomycin KW - 1404-04-2 KW - Lamivudine KW - 2T8Q726O95 KW - Mannitol KW - 3OWL53L36A KW - Zidovudine KW - 4B9XT59T7S KW - nefazodone KW - 59H4FCV1TF KW - Valproic Acid KW - 614OI1Z5WI KW - Phenytoin KW - 6158TKW0C5 KW - Vancomycin KW - 6Q205EH1VU KW - Propylthiouracil KW - 721M9407IY KW - Flutamide KW - 76W6J0943E KW - Atropine KW - 7C0697DR9I KW - Captopril KW - 9G64RSX1XD KW - Streptomycin KW - Y45QSO73OB KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Rat plasma KW - Hepatotoxicity KW - Metabolomic KW - Animals KW - Triazoles -- toxicity KW - Phenytoin -- toxicity KW - Valproic Acid -- toxicity KW - Dose-Response Relationship, Drug KW - Atropine -- toxicity KW - Captopril -- toxicity KW - Methotrexate -- toxicity KW - Rats KW - Lamivudine -- toxicity KW - Vancomycin -- toxicity KW - Zidovudine -- toxicity KW - Propylthiouracil -- toxicity KW - Neomycin -- toxicity KW - Streptomycin -- toxicity KW - Rats, Wistar KW - Oxidative Stress -- drug effects KW - Flutamide -- toxicity KW - Female KW - Male KW - Mannitol -- toxicity KW - Chemical and Drug Induced Liver Injury -- blood KW - Metabolomics -- methods KW - Liver -- drug effects KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1609309343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Detection+of+hepatotoxicity+potential+with+metabolite+profiling+%28metabolomics%29+of+rat+plasma.&rft.au=Mattes%2C+W%3BDavis%2C+K%3BFabian%2C+E%3BGreenhaw%2C+J%3BHerold%2C+M%3BLooser%2C+R%3BMellert%2C+W%3BGroeters%2C+S%3BMarxfeld%2C+H%3BMoeller%2C+N%3BMontoya-Parra%2C+G%3BProkoudine%2C+A%3Bvan+Ravenzwaay%2C+B%3BStrauss%2C+V%3BWalk%2C+T%3BKamp%2C+H&rft.aulast=Mattes&rft.aufirst=W&rft.date=2014-11-04&rft.volume=230&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2014.07.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-28 N1 - Date created - 2014-10-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2014.07.021 ER - TY - JOUR T1 - An Evaluation of an Aftermarket Local Exhaust Ventilation Device for Suppressing Respirable Dust and Respirable Crystalline Silica Dust from Powered Saws AN - 1808733928; PQ0003494070 AB - The objective of this study was to quantify the respirable dust and respirable silica exposures of roofing workers using an electric-powered circular saw with an aftermarket local exhaust ventilation attachment to cut concrete roofing tiles. The study was conducted to determine whether the local exhaust ventilation attachment was able to control respirable dust and respirable silica exposure below occupational exposure limits (OELs). Time-integrated filter samples and direct reading respirable dust concentrations were evaluated. The local exhaust ventilation consisted of a shroud attached to the cutting plane of the saw; the shroud was then connected to a small electric axial fan, which is intended to collect dust at the point of generation. All sampling was conducted with the control in use. Roofers are defined as those individuals who only lay tiles. Cutters/roofers are defined as those workers who operate the powered saw to cut tiles and also lay tiles. Respirable dust from this evaluation ranged from 0.13 to 6.59 milligrams per cubic meter (mg/m super(3)) with a geometric mean of 0.38 mg/m super(3) for roofers and from 0.45 to 3.82 mg/m super(3) with a geometric mean of 1.84 mg/m super(3) for cutters/roofers. Cutters/roofers usually handle areas close to crevices, edges, or tips of the roof whereas roofers handle areas where complete tiles can be placed. The respirable dust exposures for all cutters/roofers indicated concentrations exceeding the Occupational Safety and Health Administration's (OSHA) permissible exposure limit (PEL) for respirable dust containing silica; it was also exceeded for some of the roofers. The respirable silica concentrations ranged from 0.04 to 0.15 mg/m super(3) with a geometric mean of 0.09 mg/m super(3) for roofers, and from 0.13 to 1.21 mg/m super(3) with a geometric mean of 0.48 mg/m super(3) for cutters/roofers. As with respirable dust, the respirable silica exposures for cutters/roofers were higher than the exposures for roofers. JF - Journal of Occupational and Environmental Hygiene AU - Garcia, Alberto AU - Jones, Erica AU - Echt, Alan S AU - Hall, Ronald M AD - National Institute for Occupational Safety and Health (NIOSH), Division of Applied Research and Technology (DART), Cincinnati, Ohio Y1 - 2014/11/02/ PY - 2014 DA - 2014 Nov 02 SP - D200 EP - D207 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 11 IS - 11 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Federal regulations KW - Safety regulations KW - Ventilation KW - Occupational safety KW - Dust KW - Exhausts KW - Filters KW - Workers KW - Silica KW - Language KW - Sampling KW - Occupational exposure KW - Environmental hygiene KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808733928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=An+Evaluation+of+an+Aftermarket+Local+Exhaust+Ventilation+Device+for+Suppressing+Respirable+Dust+and+Respirable+Crystalline+Silica+Dust+from+Powered+Saws&rft.au=Garcia%2C+Alberto%3BJones%2C+Erica%3BEcht%2C+Alan+S%3BHall%2C+Ronald+M&rft.aulast=Garcia&rft.aufirst=Alberto&rft.date=2014-11-02&rft.volume=11&rft.issue=11&rft.spage=D200&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2014.955182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Filters; Workers; Silica; Ventilation; Language; Sampling; Occupational exposure; Dust; Environmental hygiene; Exhausts; Federal regulations; Safety regulations; Occupational safety DO - http://dx.doi.org/10.1080/15459624.2014.955182 ER - TY - JOUR T1 - Pharmaceutical Dust Exposure at Pharmacies Using Automatic Dispensing Machines: A Preliminary Study AN - 1808708038; PQ0003494067 AB - Automatic dispensing machines (ADMs) used in pharmacies concentrate and dispense large volumes of pharmaceuticals, including uncoated tablets that can shed dust. We evaluated 43 employees' exposures to pharmaceutical dust at three pharmacies where ADMs were used. We used an optical particle counter to identify tasks that generated pharmaceutical dust. We collected 72 inhalable dust air samples in or near the employees' breathing zones. In addition to gravimetric analysis, our contract laboratory used internal methods involving liquid chromatography to analyze these samples for active pharmaceutical ingredients (APIs) and/or lactose, an inactive filler in tablets. We had to choose samples for these additional analyses because many methods used different extraction solvents. We selected 57 samples for analysis of lactose. We used real-time particle monitoring results, observations, and information from employees on the dustiness of pharmaceuticals to select 28 samples (including 13 samples that were analyzed for lactose) for analysis of specific APIs. Pharmaceutical dust was generated during a variety of tasks like emptying and refilling of ADM canisters. Using compressed air to clean canisters and manual count machines produced the overall highest peak number concentrations (19,000-580,000 particles/L) of smallest particles (count median aerodynamic diameter less than or equal to 2 mu m). Employees who refilled, cleaned, or repaired ADM canisters, or hand filled prescriptions were exposed to higher median air concentrations of lactose (5.0-12 mu g/m super(3)) than employees who did other jobs (0.04-1.3 mu g/m super(3)), such as administrative/office work, labeling/packaging, and verifying prescriptions. We detected 10 APIs in air, including lisinopril, a drug prescribed for high blood pressure, levothyroxine, a drug prescribed for hypothyroidism, and methotrexate, a hazardous drug prescribed for cancer and other disorders. Three air concentrations of lisinopril (1.8-2.7 mu g/m super(3)) exceeded the lower bound of the manufacturer's hazard control band (1-10 mu g/m super(3)). All other API air concentrations were below applicable occupational exposure limits. Our findings indicate that some pharmacy employees are exposed to multiple APIs and that measures are needed to control those exposures. JF - Journal of Occupational and Environmental Hygiene AU - Fent, Kenneth W AU - Durgam, Srinivas AU - Mueller, Charles AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio Y1 - 2014/11/02/ PY - 2014 DA - 2014 Nov 02 SP - 695 EP - 705 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 11 IS - 11 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Particle counters KW - Contracts KW - Respiration KW - Tablets KW - Particulates KW - Dust KW - Air sampling KW - Thyroxine KW - Methotrexate KW - Drugs KW - Occupational exposure KW - Packaging KW - Environmental hygiene KW - Lactose KW - Solvents KW - Hand KW - Cancer KW - Gravimetric analysis KW - Liquid chromatography KW - Hypothyroidism KW - Pharmaceuticals KW - Hypertension KW - X 24370:Natural Toxins KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808708038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Pharmaceutical+Dust+Exposure+at+Pharmacies+Using+Automatic+Dispensing+Machines%3A+A+Preliminary+Study&rft.au=Fent%2C+Kenneth+W%3BDurgam%2C+Srinivas%3BMueller%2C+Charles&rft.aulast=Fent&rft.aufirst=Kenneth&rft.date=2014-11-02&rft.volume=11&rft.issue=11&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2014.918983 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Lactose; Respiration; Tablets; Solvents; Hand; Dust; Cancer; Liquid chromatography; Thyroxine; Pharmaceuticals; Hypothyroidism; Methotrexate; Occupational exposure; Hypertension; Environmental hygiene; Inhalation; Particle counters; Contracts; Particulates; Gravimetric analysis; Air sampling; Drugs; Packaging DO - http://dx.doi.org/10.1080/15459624.2014.918983 ER - TY - JOUR T1 - Adherence to Safe Handling Guidelines by Health Care Workers Who Administer Antineoplastic Drugs AN - 1808704928; PQ0003494065 AB - The toxicity of antineoplastic drugs is well documented. Many are known or suspected human carcinogens where no safe exposure level exists. Authoritative guidelines developed by professional practice organizations and federal agencies for the safe handling of these hazardous drugs have been available for nearly three decades. As a means of evaluating the extent of use of primary prevention practices such as engineering, administrative and work practice controls, personal protective equipment (PPE), and barriers to using PPE, the National Institute for Safety and Health (NIOSH) conducted a web survey of health care workers in 2011. The study population primarily included members of professional practice organizations representing health care occupations which routinely use or come in contact with selected chemical agents. All respondents who indicated that they administered antineoplastic drugs in the past week were eligible to complete a hazard module addressing self-reported health and safety practices on this topic. Most (98%) of the 2069 respondents of this module were nurses. Working primarily in hospitals, outpatient care centers, and physician offices, respondents reported that they had collectively administered over 90 specific antineoplastic drugs in the past week, with carboplatin, cyclophosphamide, and paclitaxel the most common. Examples of activities which increase exposure risk, expressed as percent of respondents, included: failure to wear nonabsorbent gown with closed front and tight cuffs (42%); intravenous (I.V.) tubing primed with antineoplastic drug by respondent (6%) or by pharmacy (12%); potentially contaminated clothing taken home (12%); spill or leak of antineoplastic drug during administration (12%); failure to wear chemotherapy gloves (12%); and lack of hazard awareness training (4%). The most common reason for not wearing gloves or gowns was "skin exposure was minimal"; 4% of respondents, however, reported skin contact during handling and administration. Despite the longstanding availability of safe handling guidance, recommended practices are not always followed, underscoring the importance of training and education for employers and workers. JF - Journal of Occupational and Environmental Hygiene AU - Boiano, James M AU - Steege, Andrea L AU - Sweeney, Marie H AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2014/11/02/ PY - 2014 DA - 2014 Nov 02 SP - 728 EP - 740 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 11 IS - 11 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Skin KW - Training KW - Safety KW - Guidelines KW - Antineoplastic drugs KW - Toxicity KW - Protective equipment KW - Medical personnel KW - Prevention KW - Health care KW - Safety engineering KW - Nursing KW - Gloves KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808704928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Adherence+to+Safe+Handling+Guidelines+by+Health+Care+Workers+Who+Administer+Antineoplastic+Drugs&rft.au=Boiano%2C+James+M%3BSteege%2C+Andrea+L%3BSweeney%2C+Marie+H&rft.aulast=Boiano&rft.aufirst=James&rft.date=2014-11-02&rft.volume=11&rft.issue=11&rft.spage=728&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2014.916809 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Skin; Training; Guidelines; Safety; Antineoplastic drugs; Toxicity; Protective equipment; Medical personnel; Prevention; Safety engineering; Health care; Nursing; Gloves; Occupational exposure DO - http://dx.doi.org/10.1080/15459624.2014.916809 ER - TY - JOUR T1 - Effects of comparative claims in prescription drug direct-to-consumer advertising on consumer perceptions and recall AN - 1738476597; 201539150 AB - Although pharmaceutical companies cannot make comparative claims in direct-to-consumer (DTC) ads for prescription drugs without substantial evidence, the U.S. Food and Drug Administration permits some comparisons based on labeled attributes of the drug, such as dosing. Researchers have examined comparative advertising for packaged goods; however, scant research has examined comparative DTC advertising. We conducted two studies to determine if comparative claims in DTC ads influence consumers' perceptions and recall of drug information. In Experiment 1, participants with osteoarthritis (n = 1934) viewed a fictitious print or video DTC ad that had no comparative claim or made an efficacy comparison to a named or unnamed competitor. Participants who viewed print (but not video) ads with named competitors had greater efficacy and lower risk perceptions than participants who viewed unnamed competitor and noncomparative ads. In Experiment 2, participants with high cholesterol or high body mass index (n = 5317) viewed a fictitious print or video DTC ad that had no comparative claim or made a comparison to a named or unnamed competitor. We varied the type of comparison (of indication, dosing, or mechanism of action) and whether the comparison was accompanied by a visual depiction. Participants who viewed print and video ads with named competitors had greater efficacy perceptions than participants who viewed unnamed competitor and noncomparative ads. Unlike Experiment 1, named competitors in print ads resulted in higher risk perceptions than unnamed competitors. In video ads, participants who saw an indication comparison had greater benefit recall than participants who saw dosing or mechanism of action comparisons. In addition, visual depictions of the comparison decreased risk recall for video ads. Overall, the results suggest that comparative claims in DTC ads could mislead consumers about a drug's efficacy and risk; therefore, caution should be used when presenting comparative claims in DTC ads. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - O'Donoghue, Amie C AU - Williams, Pamela A AU - Sullivan, Helen W AU - Boudewyns, Vanessa AU - Squire, Claudia AU - Willoughby, Jessica Fitts AD - Office of Prescription Drug Promotion, Center for Drug Evaluation and Research, Food and Drug Administration (FDA), 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1 EP - 11 PB - Elsevier Science, Amsterdam The Netherlands VL - 120 SN - 0277-9536, 0277-9536 KW - United States Direct-to-consumer (DTC) advertisements Prescription drugs Marketing Comparative advertising Perceived risk Communication KW - Body Weight KW - Risk KW - Consumers KW - Videotape Recordings KW - Advertising KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738476597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Effects+of+comparative+claims+in+prescription+drug+direct-to-consumer+advertising+on+consumer+perceptions+and+recall&rft.au=O%27Donoghue%2C+Amie+C%3BWilliams%2C+Pamela+A%3BSullivan%2C+Helen+W%3BBoudewyns%2C+Vanessa%3BSquire%2C+Claudia%3BWilloughby%2C+Jessica+Fitts&rft.aulast=O%27Donoghue&rft.aufirst=Amie&rft.date=2014-11-01&rft.volume=120&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2014.08.039 LA - English DB - Sociological Abstracts N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Videotape Recordings; Risk; Consumers; Advertising; Body Weight DO - http://dx.doi.org/10.1016/j.socscimed.2014.08.039 ER - TY - JOUR T1 - Effects of comparative claims in prescription drug direct-to-consumer advertising on consumer perceptions and recall AN - 1738475364; 201507453 AB - Although pharmaceutical companies cannot make comparative claims in direct-to-consumer (DTC) ads for prescription drugs without substantial evidence, the U.S. Food and Drug Administration permits some comparisons based on labeled attributes of the drug, such as dosing. Researchers have examined comparative advertising for packaged goods; however, scant research has examined comparative DTC advertising. We conducted two studies to determine if comparative claims in DTC ads influence consumers' perceptions and recall of drug information. In Experiment 1, participants with osteoarthritis (n = 1934) viewed a fictitious print or video DTC ad that had no comparative claim or made an efficacy comparison to a named or unnamed competitor. Participants who viewed print (but not video) ads with named competitors had greater efficacy and lower risk perceptions than participants who viewed unnamed competitor and noncomparative ads. In Experiment 2, participants with high cholesterol or high body mass index (n = 5317) viewed a fictitious print or video DTC ad that had no comparative claim or made a comparison to a named or unnamed competitor. We varied the type of comparison (of indication, dosing, or mechanism of action) and whether the comparison was accompanied by a visual depiction. Participants who viewed print and video ads with named competitors had greater efficacy perceptions than participants who viewed unnamed competitor and noncomparative ads. Unlike Experiment 1, named competitors in print ads resulted in higher risk perceptions than unnamed competitors. In video ads, participants who saw an indication comparison had greater benefit recall than participants who saw dosing or mechanism of action comparisons. In addition, visual depictions of the comparison decreased risk recall for video ads. Overall, the results suggest that comparative claims in DTC ads could mislead consumers about a drug's efficacy and risk; therefore, caution should be used when presenting comparative claims in DTC ads. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - O'Donoghue, Amie C AU - Williams, Pamela A AU - Sullivan, Helen W AU - Boudewyns, Vanessa AU - Squire, Claudia AU - Willoughby, Jessica Fitts AD - Office of Prescription Drug Promotion, Center for Drug Evaluation and Research, Food and Drug Administration (FDA), 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1 EP - 11 PB - Elsevier Science, Amsterdam The Netherlands VL - 120 SN - 0277-9536, 0277-9536 KW - United States Direct-to-consumer (DTC) advertisements Prescription drugs Marketing Comparative advertising Perceived risk Communication KW - Body Weight KW - Risk KW - Consumers KW - Videotape Recordings KW - Advertising KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738475364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Effects+of+comparative+claims+in+prescription+drug+direct-to-consumer+advertising+on+consumer+perceptions+and+recall&rft.au=O%27Donoghue%2C+Amie+C%3BWilliams%2C+Pamela+A%3BSullivan%2C+Helen+W%3BBoudewyns%2C+Vanessa%3BSquire%2C+Claudia%3BWilloughby%2C+Jessica+Fitts&rft.aulast=O%27Donoghue&rft.aufirst=Amie&rft.date=2014-11-01&rft.volume=120&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2014.08.039 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Videotape Recordings; Risk; Consumers; Advertising; Body Weight DO - http://dx.doi.org/10.1016/j.socscimed.2014.08.039 ER - TY - JOUR T1 - Evaluation of a New Handheld Instrument for the Detection of Counterfeit Artesunate by Visual Fluorescence Comparison AN - 1722169982; PQ0002099251 AB - There is an urgent need for accurate and inexpensive handheld instruments for the evaluation of medicine quality in the field. A blinded evaluation of the diagnostic accuracy of the Counterfeit Detection Device 3 (CD-3), developed by the US Food and Drug Administration Forensic Chemistry Center, was conducted in the Lao People's Democratic Republic. Two hundred three samples of the oral antimalarial artesunate were compared with authentic products using the CD-3 by a trainer and two trainees. The specificity (95% confidence interval [95% CI]), sensitivity (95% CI), positive predictive value (95% CI), and negative predictive value (95% CI) of the CD-3 for detecting counterfeit (falsified) artesunate were 100% (93.8-100%), 98.4% (93.8-99.7%), 100% (96.2-100%), and 97.4% (90.2-99.6%), respectively. Interobserver agreement for 203 samples of artesunate was 100%. The CD-3 holds promise as a relatively inexpensive and easy to use instrument for field evaluation of medicines, potentially empowering drug inspectors, customs agents, and pharmacists. JF - American Journal of Tropical Medicine and Hygiene AU - Ranieri, Nicola AU - Tabernero, Patricia AU - Green, Michael D AU - Verbois, Leigh AU - Herrington, James AU - Sampson, Eric AU - Satzger, R Duane AU - Phonlavong, Chindaphone AU - Thao, Khamxay AU - Newton, Paul N AU - Witkowski, Mark R AD - Forensic Chemistry Center, US Food and Drug Administration, Cincinnati, Ohio, Nicola.Ranieri@fda.hhs.gov Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 920 EP - 924 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 91 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Prediction KW - Fluorescence KW - Specificity KW - Forensic science KW - artesunate KW - Hygiene KW - Drugs KW - K 03340:Effects of Physical & Chemical Factors KW - Q1 08563:Fishing gear and methods KW - Q5 08524:Public health, medicines, dangerous organisms KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722169982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Evaluation+of+a+New+Handheld+Instrument+for+the+Detection+of+Counterfeit+Artesunate+by+Visual+Fluorescence+Comparison&rft.au=Ranieri%2C+Nicola%3BTabernero%2C+Patricia%3BGreen%2C+Michael+D%3BVerbois%2C+Leigh%3BHerrington%2C+James%3BSampson%2C+Eric%3BSatzger%2C+R+Duane%3BPhonlavong%2C+Chindaphone%3BThao%2C+Khamxay%3BNewton%2C+Paul+N%3BWitkowski%2C+Mark+R&rft.aulast=Ranieri&rft.aufirst=Nicola&rft.date=2014-11-01&rft.volume=91&rft.issue=5&rft.spage=920&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.13-0644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Prediction; Fluorescence; Specificity; Hygiene; Drugs; Forensic science; artesunate DO - http://dx.doi.org/10.4269/ajtmh.13-0644 ER - TY - JOUR T1 - Simulation Exercises to Strengthen Polio Outbreak Preparedness: Experience of the World Health Organization European Region AN - 1687688977; PQ0001574031 AB - Background. Poliovirus importations and related outbreaks continue to occur in polio-free countries, including those in the World Health Organization (WHO) European Region. National preparedness plans for responding to poliovirus introduction are insufficient in many countries of the European Region. We describe a series of polio outbreak simulation exercises that were implemented to formally test polio outbreak preparedness plans in the European Region. Methods. We designed and implemented the exercises, reviewed the results, made recommendations, and assessed the role of outbreak simulation exercises in maintaining regional polio-free status. In addition, we performed a comprehensive review of the national plans of all WHO Member States in the European Region. Results. Three exercises, delivered during 2011-2013 (for the Balkans, United Kingdom, and the Caucasus and Ukraine), revealed that participating countries were generally prepared for poliovirus introduction, but the level of preparedness needed improvement. The areas in particular need of strengthening were national preparedness plans, initial response, plans for securing vaccine supply, and communications. Conclusions. Polio outbreak simulation exercises can be valuable tools to help maintain polio-free status and should be extended to other high-risk countries and subnational areas in the European Region and elsewhere. JF - Journal of Infectious Diseases AU - Moulsdale, Hilary J AU - Khetsuriani, Nino AU - Deshevoi, Sergei AU - Butler, Robb AU - Simpson, John AU - Salisbury, David AD - Emergency Response Department, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom, hilary.moulsdale@phe.gov.uk Y1 - 2014/11/01/ PY - 2014 DA - 2014 Nov 01 SP - S208 EP - S215 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 210 SN - 0022-1899, 0022-1899 KW - Risk Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - poliovirus KW - polio outbreak simulation exercise (POSE) KW - preparedness exercise KW - polio eradication KW - Poliovirus KW - Ukraine KW - Communication KW - Simulation KW - Importation KW - Physical training KW - Communications KW - Infectious diseases KW - Reviews KW - Risk groups KW - Europe, Balkans KW - Outbreaks KW - Vaccines KW - V 22300:Methods KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687688977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Simulation+Exercises+to+Strengthen+Polio+Outbreak+Preparedness%3A+Experience+of+the+World+Health+Organization+European+Region&rft.au=Moulsdale%2C+Hilary+J%3BKhetsuriani%2C+Nino%3BDeshevoi%2C+Sergei%3BButler%2C+Robb%3BSimpson%2C+John%3BSalisbury%2C+David&rft.aulast=Moulsdale&rft.aufirst=Hilary&rft.date=2014-11-01&rft.volume=210&rft.issue=&rft.spage=S208&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu120 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Reviews; Communication; Risk groups; Vaccines; Importation; Physical training; Poliovirus; Communications; Infectious diseases; Simulation; Outbreaks; Ukraine; Europe, Balkans DO - http://dx.doi.org/10.1093/infdis/jiu120 ER - TY - JOUR T1 - Institutional Decision Making: Empowering of Health System and Economic Transformation AN - 1673612454 AB - Organized medicine (OM) is an institution built to defend the American health care system of the 20th century. The institutional structures that it employed, however, operated mechanically and independently of its practitioner base, which drew from physician and nonphysician health professions. This article suggests that OMʼs institutional structures were founded and defended by a "logic of confidence," which initially served as a buffer against external socioeconomic pressures. The institutional structures of OM came to be treated systemically as rules (e.g.,"Trust me, Iʼm a doctor" and "The doctor knows best"), biasing and guiding organizational decision making and activities. OM so effectively promoted its rules that they were installed as powerful myths in the American psyche. The author explains how OMʼs failure to adapt has impelled the strongest representatives of all health professions to resist top-down decoupling in favor of bottom-up identity maturation, applying a new "logic of appropriateness." JF - The American Psychologist AU - McGuinness, Kevin M AD - Health Resources and Services Administration, United States Public Health Service, Bureau of Health Workforce, 5600 Fishers Lane, Room 8-73, Rockville, MD 20857 ; Health Resources and Services Administration, United States Public Health Service, Bureau of Health Workforce, 5600 Fishers Lane, Room 8-73, Rockville, MD 20857 Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 817 EP - 827 CY - Washington PB - American Psychological Association VL - 69 IS - 8 SN - 0003-066X KW - Psychology KW - bias KW - decision making KW - health reform KW - public health KW - behavioral health KW - 20th century KW - Decision making KW - Health care KW - Health professionals KW - Identity KW - Maturation KW - Myths KW - Transformation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673612454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Psychologist&rft.atitle=Institutional+Decision+Making%3A+Empowering+of+Health+System+and+Economic+Transformation&rft.au=McGuinness%2C+Kevin+M&rft.aulast=McGuinness&rft.aufirst=Kevin&rft.date=2014-11-01&rft.volume=69&rft.issue=8&rft.spage=817&rft.isbn=&rft.btitle=&rft.title=The+American+Psychologist&rft.issn=0003066X&rft_id=info:doi/10.1037%2Fa0037620 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-03-31 N1 - Last updated - 2016-05-16 DO - http://dx.doi.org/10.1037/a0037620 ER - TY - JOUR T1 - Sex Moderates Associations Between Perceptions of the Physical and Social Environments and Physical Activity in Youth AN - 1665160397 AB - Purpose. To determine if the sex of the child moderates the relationships between perceptions of the physical/social environments and moderale to vigorous physical activity (MVPA) in youth. Design. Cross-sectional. Setting. North Carolina. Subjects. A final sample of 711 children, 8 to 17 years of age, was available for analysis. Measures. Self-reported presence of environmental factors previously identified to be associated xuilh physical activity in youth was collected via survey. Daily MVPA was assessed via accelerometry for a minimum of 4 days. Analysis. Multilevel linear regression models were employed, adjusted for clustering at the county and individual level. MVPA was first regressed onto sex and environmental perception items while controlling for grade and race. The interaction term behueen sex and environmental perception was then added to the model. Results. A significant positive association was observed in the first models between MVPA and two items related to parent permission to (1) walk and (2) ride a bike in the neighborhood. These effects were fully moderated by sex, with males indicating"yes" on these items exhibiting 6.87 and 5.21 more minutes of MVPA (respectively) than males indicating "no." Conclusion. Environmental perceptions appear to be related to MVPA, but this relationship is present only in males. Future research should be conducted to identify modifiable social and physical characteristics that are associated with MVPA in females. JF - American Journal of Health Promotion : AJHP. AU - Moore, Justin B AU - Beets, Michael W AU - Kaczynski, Andrew T AU - Besenyi, Gina M AU - Morris, Sara F AU - Kolbe, Mary Bea AD - Department of Health Promotion, Education, and Behavior, and Office of Public Health Practice, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Room 216, Columbia, SC 29208 ; Department of Exercise Science, University of South Carolina, Columbia, South Carolina ; Department of Health Promotion, Education, and Behavior, Arnold School of Public Health ; Division of Public Health ; Physical Activity and Nutrition Branch, Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina ; Department of Health Promotion, Education, and Behavior, and Office of Public Health Practice, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Room 216, Columbia, SC 29208 Y1 - 2014///Nov/Dec PY - 2014 DA - Nov/Dec 2014 SP - 132 EP - 135 CY - Birmingham PB - Mosby-Year Book, Inc. VL - 29 IS - 2 SN - 0890-1171 KW - Physical Fitness And Hygiene KW - Motor Activity KW - Environment KW - Child KW - Accelerometry KW - Prevention Research KW - Children KW - Clustering KW - Environmental aspects KW - Men KW - Moderated KW - Neighbourhoods KW - Perceptions KW - Permission KW - Physical activity KW - Race KW - Young people KW - North Carolina UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665160397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion+%3A+AJHP.&rft.atitle=Sex+Moderates+Associations+Between+Perceptions+of+the+Physical+and+Social+Environments+and+Physical+Activity+in+Youth&rft.au=Moore%2C+Justin+B%3BBeets%2C+Michael+W%3BKaczynski%2C+Andrew+T%3BBesenyi%2C+Gina+M%3BMorris%2C+Sara+F%3BKolbe%2C+Mary+Bea&rft.aulast=Moore&rft.aufirst=Justin&rft.date=2014-11-01&rft.volume=29&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion+%3A+AJHP.&rft.issn=08901171&rft_id=info:doi/10.4278%2Fajhp.121023-ARB-516 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - North Carolina DO - http://dx.doi.org/10.4278/ajhp.121023-ARB-516 ER - TY - JOUR T1 - The peer relationships of girls with ASD at school: comparison to boys and girls with and without ASD AN - 1665151069 AB - Background This study examines the social relationships of elementary school children with high-functioning autism, focusing on how gender relates to social preferences and acceptance, social connections, reciprocal friendships, and rejection. Method Peer nomination data were analyzed for girls with and without ASD ( n = 50) and boys with and without ASD ( n = 50). Girls and boys with ASD were matched by age, gender, and IQ. Each child with ASD was matched by age and gender to a typically developing classmate. Results Consistent with typically developing populations, children with ASD preferred, were accepted by, and primarily socialized with same-gender friends. With fewer nominations and social relationships, girls and boys with ASD appear more socially similar to each other than to the same-gender control group. Additionally, girls and boys with ASD showed higher rates of social exclusion than their typically developing peers. However, boys with ASD were more overtly socially excluded compared to girls with ASD, who seemed to be overlooked, rather than rejected. Conclusions Our data suggest a number of interesting findings in the social relationships of children with ASD in schools. Like typically developing populations, children with ASD identify with their own gender when socializing and choosing friends. But given the social differences between genders, it is likely that girls with ASD are experiencing social challenges that are different from boys with ASD. Therefore, gender is an important environmental factor to consider when planning social skills interventions at school. JF - Journal of Child Psychology and Psychiatry AU - Dean, Michelle AU - Kasari, Connie AU - Shih, Wendy AU - Frankel, Fred AU - Whitney, Rondalyn AU - Landa, Rebecca AU - Lord, Catherine AU - Orlich, Felice AU - King, Bryan AU - Harwood, Robin AD - Center for Autism Research and Treatment, University of California, Los Angeles, CA, USA. ; Center for Autism Research and Treatment, University of California, Los Angeles, CA, USA., Human Development and Psychology, University of California, Los Angeles, CA, USA. ; Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; Center for Autism and the Developing Brain, Weill Cornell Medical College, New York, NY, USA. ; Seattle Childrenʼs Hospital, University of Washington, Seattle, WC, USA. ; Health Resources and Services Administration, Rockville, MD, USA. ; Center for Autism Research and Treatment, University of California, Los Angeles, CA, USA. Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1218 EP - 1225 CY - Malden PB - Wiley Subscription Services, Inc. VL - 55 IS - 11 KW - Psychology KW - Acceptance KW - Boys KW - Girls KW - Rejection KW - Same sex KW - Social exclusion KW - Social relationships KW - Social skills KW - Autism KW - Autistic children KW - Autistic spectrum disorders KW - Children KW - Friends KW - Friendships KW - Gender KW - Gender differences KW - High functioning KW - Intelligence quotient KW - Interventions KW - Nominations KW - Peer relationships UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665151069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=The+peer+relationships+of+girls+with+ASD+at+school%3A+comparison+to+boys+and+girls+with+and+without+ASD&rft.au=Dean%2C+Michelle%3BKasari%2C+Connie%3BShih%2C+Wendy%3BFrankel%2C+Fred%3BWhitney%2C+Rondalyn%3BLanda%2C+Rebecca%3BLord%2C+Catherine%3BOrlich%2C+Felice%3BKing%2C+Bryan%3BHarwood%2C+Robin&rft.aulast=Dean&rft.aufirst=Michelle&rft.date=2014-11-01&rft.volume=55&rft.issue=11&rft.spage=1218&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Psychology+and+Psychiatry&rft.issn=&rft_id=info:doi/10.1111%2Fjcpp.12242 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-08-16 DO - http://dx.doi.org/10.1111/jcpp.12242 ER - TY - JOUR T1 - H5 N-terminal beta sheet promotes oligomerization of H7-HA1 that induces better antibody affinity maturation and enhanced protection against H7N7 and H7N9 viruses compared to inactivated influenza vaccine AN - 1664206108; PQ0001196988 AB - Initiation of mass vaccination is critical in response to influenza pandemic. There is an urgent need of a simple, rapid method for production of influenza vaccine that is more effective than current traditional influenza vaccines. Recent H7N9 transmissions to humans in China with high morbidity/mortality initiated extensive vaccine evaluation. We produced the HA1 domains (amino acids 1-320) from H7N9 and H7N7 strains in E. coli. Both were found to contain primarily monomers/trimers with low oligomeric content. However, when residues from the N-terminal beta sheet (first 8 amino acid) of H7 HA1 domains were swapped with the corresponding amino acids from H5N1, functional oligomeric H7 HA1 were produced (HA1-DS), demonstrating strong receptor binding and hemagglutination. In rabbits, the HA1-DS from either H7N9 or H7N7 generated high neutralization titers against both homologous and heterologous H7 strains, superior to the unmodified H7 HA1 proteins. In ferrets, HA1-DS from H7N7 elicited higher (and faster) HI titers, better protected ferrets from lethality, weight loss, and reduced viral loads following challenge with wild-type highly pathogenic H7N7 virus compared with inactivated H7N7 subunit vaccine. HA1-DS vaccinated ferrets were also better protected from weight loss after challenge with the heterologous H7N9 virus compared with inactivated H7N7 subunit vaccine. Importantly, the H7N7 HA1-DS vaccine induced antibody affinity maturation far superior to the inactivated H7N7 subunit vaccine, which strongly correlated with control of viral loads in the nasal washes after challenge with either H7N7 or H7N9 strains. We conclude that N-terminus beta sheet domain-swap can be used to produce stable functional oligomeric forms of better recombinant HA1 vaccines in simple, inexpensive bacterial system for rapid response to emerging pandemic threat for the global population. JF - Vaccine AU - Khurana, Surender AU - Coyle, Elizabeth M AU - Verma, Swati AU - King, Lisa R AU - Manischewitz, Jody AU - Crevar, Corey J AU - Carter, Donald M AU - Ross, Ted M AU - Golding, Hana AD - Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, MD 20903, USA Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 6421 EP - 6432 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 32 IS - 48 SN - 0264-410X, 0264-410X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Influenza KW - Vaccine KW - Hemagglutinin KW - HA1 KW - Antibody KW - Affinity KW - Immune Response KW - Ferrets KW - Bacteria KW - protein KW - Pandemic KW - H7N7 KW - H7N9 KW - Viruses KW - Population dynamics KW - Hemagglutination KW - Morbidity KW - N-Terminus KW - pandemics KW - Mustela KW - Escherichia coli KW - Neutralization KW - Mortality KW - Amino acids KW - Residues KW - Oligomerization KW - Monomers KW - Antibodies KW - Lethality KW - Proteins KW - China, People's Rep. KW - Vaccines KW - F 06905:Vaccines KW - V 22320:Replication KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664206108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=H5+N-terminal+beta+sheet+promotes+oligomerization+of+H7-HA1+that+induces+better+antibody+affinity+maturation+and+enhanced+protection+against+H7N7+and+H7N9+viruses+compared+to+inactivated+influenza+vaccine&rft.au=Khurana%2C+Surender%3BCoyle%2C+Elizabeth+M%3BVerma%2C+Swati%3BKing%2C+Lisa+R%3BManischewitz%2C+Jody%3BCrevar%2C+Corey+J%3BCarter%2C+Donald+M%3BRoss%2C+Ted+M%3BGolding%2C+Hana&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2014-11-01&rft.volume=32&rft.issue=48&rft.spage=6421&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2014.09.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 20 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Monomers; Influenza; Mortality; pandemics; Antibodies; Lethality; Amino acids; Oligomerization; Vaccines; Hemagglutination; Morbidity; N-Terminus; Residues; Viruses; Proteins; Population dynamics; Neutralization; Mustela; Escherichia coli; China, People's Rep. DO - http://dx.doi.org/10.1016/j.vaccine.2014.09.049 ER - TY - JOUR T1 - Detection and functionality of the CdtB, PltA, and PltB from Salmonella enterica serovar Javiana AN - 1660412290; PQ0001030403 AB - Salmonella infection is one of the major foodborne illnesses in the United States. Several Gram-negative bacterial pathogens, including Salmonella Typhi, produce cytolethal distending toxin (CDT), which arrests growth, induces apoptosis of infected host cells and extends persistence of pathogenic bacteria in the host. The aim of this study was to characterize the functionality of CDT (cdtB, pltA and pltB) from nontyphoidal Salmonella isolates. Fifty Salmonella enterica serovar Javiana isolates from food, environmental, and clinical samples were screened for cdtB, pltA, and pltB genes by PCR, and all were positive for all three genes. Nucleotide sequence analysis of all amplified PCR products showed 100% identity to S. Typhi cdtB. To understand the roles of CdtB, PltA, and PltB in S. Javiana, cdtB, pltA, and pltB deletion mutants were constructed using a lambda Red-based recombination system. In vitro-cultured HeLa cell lines were infected with a wild-type strain and its isogenic Delta cdtB, Delta pltA, and Delta pltB to determine whether the strains of S. Javiana are responsible for invasion and cytolethal distending intoxication, including cell cycle arrest, cytoplasmic distension, and nuclear enlargement of host target cells. The results showed that HeLa cells infected with S. Javiana wild type were arrested in G sub(2)/M and had distended cytoplasm and nuclei that were larger than those infected with S. Javiana Delta cdtB and Delta pltA strains. The S. Javiana Delta pltB strain retained the ability to induce cytoplasmic distension and cell cycle arrest, whereas the complemented Delta cdtB and Delta pltA S. Javiana strains showed activity like the wild-type strains. CdtB and pltA from S. Javiana had apparent effects on the distension of both cytoplasm and nucleus as well as cell cycle arrest of HeLa cell lines after 72 h of infection. Our data show a significant difference between the wild-type cdtB strain and its isogenic Delta cdtB for invasion of the cell lines. Therefore, CdtB produced from S. Javiana strains may play an important role in pathogenesis in host cells. The cytolethal distending toxin is an important toxin found in several Gram-negative pathogens. In this study we report for the first time the functionality of cdtB, pltA and pltB in non-typhoidal S. Javiana during infection in HeLa cell lines. JF - Pathogens and Disease AU - Mezal, Ezat H AU - Bae, Dongryeoul AU - Khan, Ashraf A AD - Division of Microbiology, National Center for Toxicological Research, U. S. Food and Drug Administration, Jefferson, AR, USA. Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 95 EP - 103 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 England VL - 72 IS - 2 SN - 2049-632X, 2049-632X KW - Microbiology Abstracts B: Bacteriology KW - Intoxication KW - cytolethal distending toxin KW - Data processing KW - Distension KW - Deletion mutant KW - Apoptosis KW - Salmonella typhi KW - Nucleotide sequence KW - Food KW - Cell cycle KW - Pathogens KW - Infection KW - Recombination KW - Salmonella enterica KW - Cytoplasm KW - Polymerase chain reaction KW - Nuclei KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660412290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pathogens+and+Disease&rft.atitle=Detection+and+functionality+of+the+CdtB%2C+PltA%2C+and+PltB+from+Salmonella+enterica+serovar+Javiana&rft.au=Mezal%2C+Ezat+H%3BBae%2C+Dongryeoul%3BKhan%2C+Ashraf+A&rft.aulast=Mezal&rft.aufirst=Ezat&rft.date=2014-11-01&rft.volume=72&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Pathogens+and+Disease&rft.issn=2049632X&rft_id=info:doi/10.1111%2F2049-632X.12191 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Intoxication; cytolethal distending toxin; Apoptosis; Deletion mutant; Distension; Data processing; Food; Nucleotide sequence; Cell cycle; Pathogens; Infection; Recombination; Cytoplasm; Polymerase chain reaction; Nuclei; Salmonella typhi; Salmonella enterica DO - http://dx.doi.org/10.1111/2049-632X.12191 ER - TY - JOUR T1 - Effects of comparative claims in prescription drug direct-to-consumer advertising on consumer perceptions and recall AN - 1660030777; 4650005 AB - Although pharmaceutical companies cannot make comparative claims in direct-to-consumer (DTC) ads for prescription drugs without substantial evidence, the U.S. Food and Drug Administration permits some comparisons based on labeled attributes of the drug, such as dosing. Researchers have examined comparative advertising for packaged goods; however, scant research has examined comparative DTC advertising. We conducted two studies to determine if comparative claims in DTC ads influence consumers' perceptions and recall of drug information. In Experiment 1, participants with osteoarthritis (n = 1934) viewed a fictitious print or video DTC ad that had no comparative claim or made an efficacy comparison to a named or unnamed competitor. Participants who viewed print (but not video) ads with named competitors had greater efficacy and lower risk perceptions than participants who viewed unnamed competitor and noncomparative ads. In Experiment 2, participants with high cholesterol or high body mass index (n = 5317) viewed a fictitious print or video DTC ad that had no comparative claim or made a comparison to a named or unnamed competitor. We varied the type of comparison (of indication, dosing, or mechanism of action) and whether the comparison was accompanied by a visual depiction. Participants who viewed print and video ads with named competitors had greater efficacy perceptions than participants who viewed unnamed competitor and noncomparative ads. Unlike Experiment 1, named competitors in print ads resulted in higher risk perceptions than unnamed competitors. In video ads, participants who saw an indication comparison had greater benefit recall than participants who saw dosing or mechanism of action comparisons. In addition, visual depictions of the comparison decreased risk recall for video ads. Overall, the results suggest that comparative claims in DTC ads could mislead consumers about a drug's efficacy and risk; therefore, caution should be used when presenting comparative claims in DTC ads. All rights reserved, Elsevier JF - Social science and medicine AU - Sullivan, Helen W AU - Boudewyns, Vanessa AU - Squire, Claudia AU - Willoughby, Jessica Fitts AU - O' Donoghue, Amie C AU - Williams, Pamela A AD - US Department of Health and Human Services ; RTI International Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1 EP - 11 VL - 120 SN - 0277-9536, 0277-9536 KW - Sociology KW - Communication KW - Marketing KW - Pharmaceuticals KW - Medicine KW - U.S.A. KW - Social sciences KW - Risk theory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660030777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+science+and+medicine&rft.atitle=Effects+of+comparative+claims+in+prescription+drug+direct-to-consumer+advertising+on+consumer+perceptions+and+recall&rft.au=Sullivan%2C+Helen+W%3BBoudewyns%2C+Vanessa%3BSquire%2C+Claudia%3BWilloughby%2C+Jessica+Fitts%3BO%27+Donoghue%2C+Amie+C%3BWilliams%2C+Pamela+A&rft.aulast=Sullivan&rft.aufirst=Helen&rft.date=2014-11-01&rft.volume=120&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Social+science+and+medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2014.08.039 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-03-02 N1 - Last updated - 2015-03-03 N1 - SubjectsTermNotLitGenreText - 7738 11245 11239; 2572; 11920; 9474; 11040 11035; 7894; 433 293 14 DO - http://dx.doi.org/10.1016/j.socscimed.2014.08.039 ER - TY - JOUR T1 - Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats AN - 1647005565; 21285849 AB - Cyproterone acetate (CPA), a synthetic hormonal drug, induces rat liver tumors in a sex-specific manner, with five-fold higher doses needed to induce liver tumors in male rats compared to females. In order to evaluate the potential of the in vivo alkaline Comet assay to predict the sex-specific carcinogenicity of CPA, CPA-induced direct DNA damage (DNA strand breaks and alkali-labile sites) were evaluated in the livers of both male and female F344 rats. In addition, secondary oxidative DNA damage was measured concurrently utilizing the human 8-oxoguanine-DNA-N-glycosylase (hOGG1) and EndonucleaseIII (EndoIII)-modified in vivo alkaline Comet assays and the reticulocyte micronucleus (MN) frequency was analyzed in peripheral blood. Groups of 5 seven-week-old male and female F344 rats received olive oil or 10, 25, 50 or 100mg/kg bw CPA in olive oil by gavage at 0, 24, and 45h and were sacrificed at 48h. CPA-induced direct DNA damage in rat liver showed the same sex-specific pattern as its hepatotumorigenicity: a five-fold-higher dose of CPA was needed to induce a statistically significant increase in direct DNA damage in livers of males compared to females. However, peripheral blood MN frequency was weak in both sexes and CPA-induced oxidative DNA damage was generally greater in male than female rat livers. Taken together, our results demonstrate concordance in the sex-specificity of CPA in the in vivo alkaline Comet assay and cancer bioassay, while the induction of oxidative DNA damage by CPA was not directly correlated with its tumorigenicity. JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Ding, Wei AU - Bishop, Michelle E AU - Pearce, Mason G AU - Davis, Kelly J AU - White, Gene A AU - Lyn-Cook, Lascelles E AU - Manjanatha, Mugimane G AD - Division of Genetic and Molecular Toxicology, US FDA/National Center for Toxicological Research, Jefferson, AR 72079, United States Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1 EP - 7 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 774 SN - 1383-5718, 1383-5718 KW - Genetics Abstracts; Toxicology Abstracts KW - CPA cyproterone acetate KW - COC combined oral contraceptive KW - VTE venous thromboembolism KW - hOGG1 human 8-oxoguanine DNA N-glycosylase 1 KW - EndoIII endonuclease-III KW - ROS reactive oxygen species KW - LOEL lowest observable effect level KW - MN micronucleus KW - bw by weight KW - Cyproterone acetate (CPA) KW - In vivo Comet assay KW - Liver KW - DNA damage KW - Oxidative DNA damage KW - Sex-specific genotoxicity KW - Genotoxicity KW - Statistical analysis KW - Tumorigenicity KW - Peripheral blood KW - Tumors KW - Sex differences KW - Olive oil KW - Acetic acid KW - Cancer KW - Mutagenesis KW - Cyproterone acetate KW - Carcinogenicity KW - Comet assay KW - Drugs KW - Manganese KW - Reticulocytes KW - Sex KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647005565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Sex-specific+dose-response+analysis+of+genotoxicity+in+cyproterone+acetate-treated+F344+rats&rft.au=Ding%2C+Wei%3BBishop%2C+Michelle+E%3BPearce%2C+Mason+G%3BDavis%2C+Kelly+J%3BWhite%2C+Gene+A%3BLyn-Cook%2C+Lascelles+E%3BManjanatha%2C+Mugimane+G&rft.aulast=Ding&rft.aufirst=Wei&rft.date=2014-11-01&rft.volume=774&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2014.08.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Genotoxicity; Statistical analysis; Tumorigenicity; Peripheral blood; Tumors; Olive oil; Sex differences; Acetic acid; Cancer; Mutagenesis; DNA damage; Cyproterone acetate; Carcinogenicity; Liver; Comet assay; Reticulocytes; Manganese; Drugs; Sex DO - http://dx.doi.org/10.1016/j.mrgentox.2014.08.005 ER - TY - JOUR T1 - Differential effects of triclosan on the activation of mouse and human peroxisome proliferator-activated receptor alpha AN - 1647003672; 21286153 AB - Triclosan is an anti-bacterial agent used in many personal care products, household items, medical devices, and clinical settings. Liver tumors occur in mice exposed to triclosan, a response attributed to peroxisome proliferator-activated receptor alpha (PPAR alpha ) activation; however, the effects of triclosan on mouse and human PPAR alpha have not been fully evaluated. We compared the effects of triclosan on mouse and human PPAR alpha using PPAR alpha reporter assays and on downstream events of PPAR alpha activation using mouse hepatoma Hepa1c1c7 cells and human hepatoma HepG2 cells. PPAR alpha transcriptional activity was increased by triclosan in a mouse PPAR alpha reporter assay and decreased in a human PPAR alpha reporter assay. Concentrations of triclosan inhibiting 50% cell growth were similar in both human and mouse hepatoma cells. Western blotting analysis showed that triclosan increased acyl-coenzyme A oxidase (ACOX1), a PPAR alpha target, in Hepa1c1c7 cells but decreased the level in HepG2 cells. Treatment of Hepa1c1c7 cells with triclosan enhanced DNA synthesis and suppressed transforming growth factor beta-mediated apoptosis. This did not occur in HepG2 cells. These data demonstrate that triclosan had similar cytotoxicity in Hepa1c1c7 and HepG2 cells, but differential effects on the activation of PPAR alpha , the expression of ACOX1, and downstream events including DNA synthesis and apoptosis. JF - Toxicology Letters AU - Wu, Yuanfeng AU - Wu, Qiangen AU - Beland, Frederick A AU - Ge, Peter AU - Manjanatha, Mugimane G AU - Fang, Jia-Long AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, HFT-110, Jefferson, AR 72079, USA Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 17 EP - 28 PB - Elsevier B.V., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 231 IS - 1 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts KW - Triclosan KW - PPAR alpha KW - DNA synthesis KW - Apoptosis KW - Hepatoma KW - DNA biosynthesis KW - Western blotting KW - Cytotoxicity KW - Data processing KW - Peroxisome proliferator-activated receptors KW - Liver KW - Transcription KW - Tumors KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647003672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Differential+effects+of+triclosan+on+the+activation+of+mouse+and+human+peroxisome+proliferator-activated+receptor+alpha&rft.au=Wu%2C+Yuanfeng%3BWu%2C+Qiangen%3BBeland%2C+Frederick+A%3BGe%2C+Peter%3BManjanatha%2C+Mugimane+G%3BFang%2C+Jia-Long&rft.aulast=Wu&rft.aufirst=Yuanfeng&rft.date=2014-11-01&rft.volume=231&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2014.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Western blotting; DNA biosynthesis; Hepatoma; Cytotoxicity; Data processing; Apoptosis; Peroxisome proliferator-activated receptors; Liver; Transcription; Tumors; Triclosan DO - http://dx.doi.org/10.1016/j.toxlet.2014.09.001 ER - TY - JOUR T1 - Optimizing dosing of oncology drugs. AN - 1635012184; 25105705 AB - The purpose of this article is to acknowledge the challenges in optimizing the dosing of oncology drugs and to propose potential approaches to address these challenges in order to optimize effectiveness, minimize toxicity, and promote adherence in patients. These approaches could provide better opportunities to understand the sources of variability in drug exposure and clinical outcomes during the development and premarketing evaluation of investigational new drugs. JF - Clinical pharmacology and therapeutics AU - Minasian, L AU - Rosen, O AU - Auclair, D AU - Rahman, A AU - Pazdur, R AU - Schilsky, R L AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA. ; Millennium: The Takeda Oncology Company, Cambridge, Massachusetts, USA. ; Multiple Myeloma Research Foundation, Norwalk, Connecticut, USA. ; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. ; American Society of Clinical Oncology, Alexandria, Virginia, USA. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 572 EP - 579 VL - 96 IS - 5 KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Medication Adherence KW - Dose-Response Relationship, Drug KW - Humans KW - Time Factors KW - Antineoplastic Agents -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635012184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Optimizing+dosing+of+oncology+drugs.&rft.au=Minasian%2C+L%3BRosen%2C+O%3BAuclair%2C+D%3BRahman%2C+A%3BPazdur%2C+R%3BSchilsky%2C+R+L&rft.aulast=Minasian&rft.aufirst=L&rft.date=2014-11-01&rft.volume=96&rft.issue=5&rft.spage=572&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2014.153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-23 N1 - Date created - 2014-10-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/clpt.2014.153 ER - TY - RPRT T1 - FOREWORD AN - 1629597454 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629597454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-11-01&rft.volume=&rft.issue=588&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2014 N1 - Last updated - 2015-03-21 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF GLYCIDAMIDE (CAS NO. 5694-00-8) IN F344/N Nctr RATS AND B6C3F1/Nctr MICE (DRINKING WATER STUDIES) AN - 1629597310 AB - Glycidamide is a reactive electrophile that occurs primarily as a metabolite of acrylamide. Because acrylamide can be formed as a by-product during the cooking of starchy foods and the roasting of coffee, the National Toxicology Program performed simultaneous studies to determine and compare the long-term effects of actylamide and glycidamide in male and female rats and mice. Results revealed that animals receiving 0.70 mM glycidamide had lower survival rates than the controls. The rates of several types of cancer increased in each of the animal studies. Glycidamide in the drinking water caused cancer in several different tissues in male and female rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1 EP - 15,17-35,37-101,103-125,127-163,165-183,185-189,191-205,207-209,211-213,215-217,219-275 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Cancer KW - Rodents KW - Chemical compounds KW - Toxicology KW - Toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629597310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+GLYCIDAMIDE+%28CAS+NO.+5694-00-8%29+IN+F344%2FN+Nctr+RATS+AND+B6C3F1%2FNctr+MICE+%28DRINKING+WATER+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-11-01&rft.volume=&rft.issue=588&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2014 N1 - Document feature - Illustrations; Tables; Graphs; References N1 - Last updated - 2015-03-21 ER - TY - RPRT T1 - Table of contents AN - 1629597290 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629597290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-11-01&rft.volume=&rft.issue=588&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2014 N1 - Last updated - 2015-03-21 ER - TY - JOUR T1 - Development of a microchip Europium nanoparticle immunoassay for sensitive point-of-care HIV detection AN - 1627954298; 20952177 AB - Rapid, sensitive and specific diagnostic assays play an indispensable role in determination of HIV infection stages and evaluation of efficacy of antiretroviral therapy. Recently, our laboratory developed a sensitive Europium nanoparticle-based microtiter-plate immunoassay capable of detecting target analytes at subpicogram per milliliter levels without the use of catalytic enzymes and signal amplification processes. Encouraged by its sensitivity and simplicity, we continued to miniaturize this assay to a microchip platform for the purpose of converting the benchtop assay technique to a point-of-care test. It was found that detection capability of the microchip platform could be readily improved using Europium nanoparticle probes. We were able to routinely detect 5pg/mL (4.6 attomoles) of HIV-1 p24 antigen at a signal-to-blank ratio of 1.5, a sensitivity level reasonably close to that of microtiter-plate Europium nanoparticle assay. Meanwhile, use of the microchip platform effectively reduced sample/reagent consumption 4.5 fold and shortened total assay time 2 fold in comparison with microtiter plate assays. Complex matrix substance in plasma negatively affected the microchip assays and the effects could be minimized by diluting the samples before loading. With further improvements in sensitivity, reproducibility, usability, assay process simplification, and incorporation of portable time-resolved fluorescence reader, Europium nanoparticle immunoassay technology could be adapted to meet the challenges of point-of-care diagnosis of HIV or other health-threatening pathogens at bedside or in resource-limited settings. JF - Biosensors and Bioelectronics AU - Liu, Jikun AU - Du, Bingchen AU - Zhang, Panhe AU - Haleyurgirisetty, Mohan AU - Zhao, Jiangqin AU - Ragupathy, Viswanath AU - Lee, Sherwin AU - DeVoe, Don L AU - Hewlett, Indira K AD - Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 177 EP - 183 PB - Elsevier B.V., 660 White Plains Rd. Tarrytown NY 10591-5153 United States VL - 61 SN - 0956-5663, 0956-5663 KW - Biotechnology and Bioengineering Abstracts KW - Europium nanoparticles KW - Microchip KW - Point-of-care diagnostics KW - HIV KW - Resource-limited settings KW - p24 protein KW - Fluorescence KW - antiretroviral therapy KW - Probes KW - Enzymes KW - Pathogens KW - Infection KW - Biosensors KW - Human immunodeficiency virus 1 KW - microchips KW - nanoparticles KW - Immunoassays KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627954298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=Development+of+a+microchip+Europium+nanoparticle+immunoassay+for+sensitive+point-of-care+HIV+detection&rft.au=Liu%2C+Jikun%3BDu%2C+Bingchen%3BZhang%2C+Panhe%3BHaleyurgirisetty%2C+Mohan%3BZhao%2C+Jiangqin%3BRagupathy%2C+Viswanath%3BLee%2C+Sherwin%3BDeVoe%2C+Don+L%3BHewlett%2C+Indira+K&rft.aulast=Liu&rft.aufirst=Jikun&rft.date=2014-11-01&rft.volume=61&rft.issue=&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2014.04.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Biosensors; p24 protein; Fluorescence; antiretroviral therapy; microchips; Probes; Enzymes; Pathogens; Infection; Immunoassays; nanoparticles; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.bios.2014.04.057 ER - TY - GEN T1 - Human and animal evidence supports lower occupational exposure limits for poorly-soluble respirable particles: Letter to the Editor re: 'Low-toxicity dusts: Current exposure guidelines are not sufficiently protective' by Cherrie, Brosseau, Hay and Donaldson. AN - 1624934076; 25193937 JF - The Annals of occupational hygiene AU - Kuempel, Eileen D AU - Attfield, Michael D AU - Stayner, Leslie T AU - Castranova, Vincent Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1205 EP - 1208 VL - 58 IS - 9 KW - Dust KW - 0 KW - Index Medicus KW - Humans KW - Guidelines as Topic -- standards KW - Dust -- analysis KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1624934076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Human+and+animal+evidence+supports+lower+occupational+exposure+limits+for+poorly-soluble+respirable+particles%3A+Letter+to+the+Editor+re%3A+%27Low-toxicity+dusts%3A+Current+exposure+guidelines+are+not+sufficiently+protective%27+by+Cherrie%2C+Brosseau%2C+Hay+and+Donaldson.&rft.au=Kuempel%2C+Eileen+D%3BAttfield%2C+Michael+D%3BStayner%2C+Leslie+T%3BCastranova%2C+Vincent&rft.aulast=Kuempel&rft.aufirst=Eileen&rft.date=2014-11-01&rft.volume=58&rft.issue=9&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmeu058 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-23 N1 - Date created - 2014-11-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 1997 Sep;105 Suppl 5:1337-46 [9400748] Toxicol Sci. 2005 Dec;88(2):614-29 [16177241] Toxicol Pathol. 2007 Jan;35(1):136-47 [17325982] Inhal Toxicol. 2007;19 Suppl 1:189-98 [17886067] Am J Ind Med. 2008 Apr;51(4):231-45 [18247381] Occup Environ Med. 2010 Apr;67(4):270-6 [19819863] J Radiol Prot. 2010 Sep;30(3):491-512 [20826887] Radiat Prot Dosimetry. 2011 Mar;144(1-4):353-6 [21036808] Occup Environ Med. 2011 Dec;68(12):908-13 [21597107] Ann Occup Hyg. 2013 Jul;57(6):685-91 [23835898] Occup Environ Med. 2014 Jan;71(1):30-9 [24186945] Fundam Appl Toxicol. 1997 May;37(1):37-53 [9193921] Inhal Toxicol. 1999 Dec;11(12):1059-76 [10562697] Drug Chem Toxicol. 2000 Feb;23(1):203-22 [10711398] Inhal Toxicol. 2000 Jan-Feb;12(1-2):1-17 [10715616] Inhal Toxicol. 2000 Dec;12(12):1113-26 [11114784] Regul Toxicol Pharmacol. 2001 Aug;34(1):69-87 [11502158] Regul Toxicol Pharmacol. 2001 Aug;34(1):88-101 [11502159] Toxicol Sci. 2002 Nov;70(1):86-97 [12388838] Toxicol Sci. 2004 Feb;77(2):347-57 [14600271] Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:40-8 [15209402] Fundam Appl Toxicol. 1988 Apr;10(3):369-84 [3286345] Crit Rev Toxicol. 1989;20(3):175-211 [2692607] Fundam Appl Toxicol. 1991 Aug;17(2):300-13 [1662649] Exp Lung Res. 1992 Jan-Mar;18(1):87-104 [1572327] Am J Ind Med. 1995 Jan;27(1):137-51 [7900731] Fundam Appl Toxicol. 1995 Nov;28(1):41-50 [8566482] Comment On: Ann Occup Hyg. 2013 Jul;57(6):685-91 [23835898] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/annhyg/meu058 ER - TY - JOUR T1 - A shared regulatory perspective on deferral from blood donation of men who have sex with men (MSM) AN - 1622617344; 20869712 AB - National Regulatory Authorities (NRAs) establish deferral criteria for donors with risk factors for transfusion transmissible infections (TTI). In most jurisdictions, epidemiological data show that men who have sex with men (MSM) have a significantly higher rate of TTI than the general population. Nevertheless, changes from an indefinite donor deferral for MSM have been considered in many countries in response to concerns over a perceived discrimination and questioning of the scientific need. Changes to MSM donor deferral criteria should be based on sound scientific evidence. Safety of transfusion recipients should be the first priority, and stakeholder input should be sought. JF - Vox Sanguinis AU - Epstein, J AU - Ganz, PR AU - Seitz, R AU - Jutzi, M AU - Schaerer, C AU - Michaud, G AU - Agbanyo, F AU - Smith, G AU - Prosser, I AU - Heiden, M AU - Saint-Marie, I AU - Oualikene-Gonin, W AU - Hamaguchi, I AU - Yasuda, N AD - Office of Blood Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 416 EP - 419 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 107 IS - 4 SN - 0042-9007, 0042-9007 KW - Risk Abstracts KW - Stakeholders KW - Blood donors KW - Perception KW - Risk factors KW - Jurisdiction KW - Safety KW - Discrimination KW - Priorities KW - Homosexuality KW - Transfusion KW - Infection KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622617344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vox+Sanguinis&rft.atitle=A+shared+regulatory+perspective+on+deferral+from+blood+donation+of+men+who+have+sex+with+men+%28MSM%29&rft.au=Epstein%2C+J%3BGanz%2C+PR%3BSeitz%2C+R%3BJutzi%2C+M%3BSchaerer%2C+C%3BMichaud%2C+G%3BAgbanyo%2C+F%3BSmith%2C+G%3BProsser%2C+I%3BHeiden%2C+M%3BSaint-Marie%2C+I%3BOualikene-Gonin%2C+W%3BHamaguchi%2C+I%3BYasuda%2C+N&rft.aulast=Epstein&rft.aufirst=J&rft.date=2014-11-01&rft.volume=107&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Vox+Sanguinis&rft.issn=00429007&rft_id=info:doi/10.1111%2Fvox.12166 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2014-11-26 N1 - SubjectsTermNotLitGenreText - Blood donors; Stakeholders; Perception; Risk factors; Safety; Jurisdiction; Priorities; Discrimination; Homosexuality; Infection; Transfusion DO - http://dx.doi.org/10.1111/vox.12166 ER - TY - JOUR T1 - The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance AN - 1622601249; 20869475 AB - The biopharmaceutics risk assessment roadmap (BioRAM) optimizes drug product development and performance by using therapy-driven target drug delivery profiles as a framework to achieve the desired therapeutic outcome. Hence, clinical relevance is directly built into early formulation development. Biopharmaceutics tools are used to identify and address potential challenges to optimize the drug product for patient benefit. For illustration, BioRAM is applied to four relatively common therapy-driven drug delivery scenarios: rapid therapeutic onset, multiphasic delivery, delayed therapeutic onset, and maintenance of target exposure. BioRAM considers the therapeutic target with the drug substance characteristics and enables collection of critical knowledge for development of a dosage form that can perform consistently for meeting the patient's needs. Accordingly, the key factors are identified and in vitro, in vivo, and in silico modeling and simulation techniques are used to elucidate the optimal drug delivery rate and pattern. BioRAM enables (1) feasibility assessment for the dosage form, (2) development and conduct of appropriate "learning and confirming" studies, (3) transparency in decision-making, (4) assurance of drug product quality during lifecycle management, and (5) development of robust linkages between the desired clinical outcome and the necessary product quality attributes for inclusion in the quality target product profile. copyright 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3377-3397, 2014 JF - Journal of Pharmaceutical Sciences AU - Selen, Arzu AU - Dickinson, Paul A AU - Muellertz, Anette AU - Crison, John R AU - Mistry, Hitesh B AU - Cruanes, Maria T AU - Martinez, Marilyn N AU - Lennernaes, Hans AU - Wigal, Tim L AU - Swinney, David C AU - Polli, James E AU - Serajuddin, Abu TM AU - Cook, Jack A AU - Dressman, Jennifer B AD - Office of New Drug Quality Assessment, US Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland. Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 3377 EP - 3397 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 103 IS - 11 SN - 0022-3549, 0022-3549 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Drug delivery KW - Decision making KW - Learning KW - Drug development KW - Development KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622601249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=The+Biopharmaceutics+Risk+Assessment+Roadmap+for+Optimizing+Clinical+Drug+Product+Performance&rft.au=Selen%2C+Arzu%3BDickinson%2C+Paul+A%3BMuellertz%2C+Anette%3BCrison%2C+John+R%3BMistry%2C+Hitesh+B%3BCruanes%2C+Maria+T%3BMartinez%2C+Marilyn+N%3BLennernaes%2C+Hans%3BWigal%2C+Tim+L%3BSwinney%2C+David+C%3BPolli%2C+James+E%3BSerajuddin%2C+Abu+TM%3BCook%2C+Jack+A%3BDressman%2C+Jennifer+B&rft.aulast=Selen&rft.aufirst=Arzu&rft.date=2014-11-01&rft.volume=103&rft.issue=11&rft.spage=3377&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24162 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2014-11-12 N1 - SubjectsTermNotLitGenreText - Risk assessment; Decision making; Drug delivery; Learning; Drug development; Development DO - http://dx.doi.org/10.1002/jps.24162 ER - TY - JOUR T1 - Evolution of the Food and Drug Administration approach to liver safety assessment for new drugs: current status and challenges. AN - 1618826722; 25352324 AB - Prompted by approval in 1997 of troglitazone and bromfenac, two drugs that promptly began to show serious and sometimes fatal liver toxicity, we began at the Food and Drug Administration (FDA) a series of annual conferences in 1999 to consider issues of drug-induced liver injury (DILI). First inviting reviewers of new drug applications we opened the audiences in 2001 to pharmaceutical industry and academic consultants to industry and FDA, and slides shown at the meetings were posted on the internet to be available at the website of the American Association for the Study of Liver Diseases (AASLD)-go to ( http://www.aasld.org/dili/Pages/default.aspx ). Observations by Dr. Hyman J. Zimmerman that "drug-induced hepatocellular jaundice is a serious lesion" with possible mortality formed a basis for developing a computer program to plot peak serum values for alanine aminotransferase (ALT) and total bilirubin (TBL) in an x-y log-log graph for all subjects enrolled in clinical trials. This program had the capability to show the time course of all liver tests for individuals who had both hepatocellular injury and reduced whole liver function, plus clinical narratives to diagnose the severity and most likely cause of the abnormalities. We called the program eDISH (for evaluation of Drug-Induced Serious Hepatotoxicity), and began in 2004 to use it to assess DILI in clinical trial subjects. From 2008, comments made by the presenters at the conferences about their slides and ensuing discussions have been added to the website. All this has raised awareness of the problem, and since 1997, the FDA has not had to withdraw a single drug because of post-marketing hepatotoxicity. Many issues still remain to be resolved; among the most controversial is the best method to estimate likelihood that a given liver injury was actually caused by the drug in question. On November 9, 2012, a workshop was convened to discuss the best practices for the assessment of drug-induced liver injury (DILI) in clinical trials. JF - Drug safety AU - Senior, John R AD - Office of Pharmacovigilance and Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993-0002, USA, john.senior@fda.hhs.gov. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - S9 EP - 17 VL - 37 Suppl 1 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Humans KW - Drug-Related Side Effects and Adverse Reactions -- diagnosis KW - Safety-Based Drug Withdrawals -- statistics & numerical data KW - Chemical and Drug Induced Liver Injury -- prevention & control KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Diagnosis, Computer-Assisted KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1618826722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Evolution+of+the+Food+and+Drug+Administration+approach+to+liver+safety+assessment+for+new+drugs%3A+current+status+and+challenges.&rft.au=Senior%2C+John+R&rft.aulast=Senior&rft.aufirst=John&rft.date=2014-11-01&rft.volume=37+Suppl+1&rft.issue=&rft.spage=S9&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=1179-1942&rft_id=info:doi/10.1007%2Fs40264-014-0182-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-29 N1 - Date created - 2014-10-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: N Engl J Med. 2000 Feb 3;342(5):359-60 [10660405] Am J Health Syst Pharm. 2000 May 1;57(9):834 [10840515] JAMA. 1999 May 12;281(18):1728-34 [10328074] Am J Gastroenterol. 1999 May;94(5):1393-6 [10235225] Ann Hepatol. 2014 Mar-Apr;13(2):248-55 [24552867] Hepatology. 2014 Feb;59(2):661-70 [24037963] Clin Mol Hepatol. 2013 Jun;19(2):105-15 [23837134] Clin Pharmacol Ther. 2012 Sep;92(3):332-9 [22871997] Pharmacoepidemiol Drug Saf. 2011 Jul;20(7):772-7 [21574210] Drug Saf. 2011 Mar 1;34(3):243-52 [21332248] Hepatology. 2010 Jun;51(6):2117-26 [20512999] Ann Intern Med. 1959 Dec;51:1230-52 [14434187] Science. 1959 Jul 3;130(3366):9-21 [13668531] Mayo Clin Health Lett. 1998 Nov;16(11):4 [9809019] N Engl J Med. 1998 Mar 26;338(13):916-7 [9518284] BMJ. 1997 Dec 13;315(7122):1564 [9437272] Am J Health Syst Pharm. 1997 Oct 1;54(19):2151-2 [9331432] Cleve Clin J Med. 1997 May;64(5):238-40 [9149473] J Clin Epidemiol. 1993 Nov;46(11):1331-6 [8229111] J Clin Epidemiol. 1993 Nov;46(11):1323-30 [8229110] Hepatology. 1989 Jul;10(1):1-7 [2737595] Perspect Biol Med. 1968 Autumn;12(1):135-61 [4387099] N Engl J Med. 1966 May 26;274(21):1171-3 [5934954] Hepatology. 2004 Feb;39(2):574-8 [14768020] Drug Saf. 2002;25(6):381-92 [12071774] Clin Infect Dis. 2000 Feb;30(2):400-1 [10671353] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s40264-014-0182-7 ER - TY - JOUR T1 - Comparison of blood volatile organic compound levels in residents of Calcasieu and Lafayette Parishes, LA, with US reference ranges. AN - 1615742664; 24472757 AB - Agency for Toxic Substances and Disease Registry conducted a study to evaluate body burden levels of volatile organic compounds (VOCs) among residents of highly industrialized Calcasieu Parish, LA, USA, in 2002. Blood VOC levels in a representative sample of participants in Calcasieu Parish were compared with a similar group of participants in the less-industrialized Lafayette Parish. Participants' ages ranged from 15 to 91 years, 46% were men, and 89% were Caucasian. VOC levels in these two populations were also compared at the national levels. Solid-phase microextraction coupled with gas chromatography mass spectrometry was used to measure levels of 30 VOCs in blood samples collected from 283 self-described non-smoking study participants. Of the 30 VOCs, 6 had quantifiable levels in at least 25% of the blood samples analyzed. The frequency of detection was >95% for benzene and m-/p-xylene, >60% for 1,4-dichlorbenzene and toluene, 27% for ethylbenzene, and 39% for styrene. Calcasieu and Lafayette Parish participants had similar distributions for six VOCs in key percentiles and geometric means. When compared with a representative sampling of the 1999-2000 US general population, no significant differences were found between the parish data and the US general population. JF - Journal of exposure science & environmental epidemiology AU - Uddin, Mohammed S AU - Blount, Benjamin C AU - Lewin, Michael D AU - Potula, Vijayalakshmi AU - Ragin, Angela D AU - Dearwent, Steve M AD - Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA, USA. ; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. ; Office of the Director, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 602 EP - 607 VL - 24 IS - 6 KW - Air Pollutants KW - 0 KW - Volatile Organic Compounds KW - Index Medicus KW - United States KW - Young Adult KW - Reference Values KW - Air Pollution -- analysis KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - Aged KW - Smoking -- epidemiology KW - Aged, 80 and over KW - Logistic Models KW - Adult KW - Gas Chromatography-Mass Spectrometry KW - Middle Aged KW - Adolescent KW - Male KW - Environmental Monitoring -- methods KW - Female KW - Louisiana -- epidemiology KW - Industry KW - Volatile Organic Compounds -- classification KW - Air Pollutants -- blood KW - Volatile Organic Compounds -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1615742664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Comparison+of+blood+volatile+organic+compound+levels+in+residents+of+Calcasieu+and+Lafayette+Parishes%2C+LA%2C+with+US+reference+ranges.&rft.au=Uddin%2C+Mohammed+S%3BBlount%2C+Benjamin+C%3BLewin%2C+Michael+D%3BPotula%2C+Vijayalakshmi%3BRagin%2C+Angela+D%3BDearwent%2C+Steve+M&rft.aulast=Uddin&rft.aufirst=Mohammed&rft.date=2014-11-01&rft.volume=24&rft.issue=6&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=1559-064X&rft_id=info:doi/10.1038%2Fjes.2013.94 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-22 N1 - Date created - 2014-10-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/jes.2013.94 ER - TY - JOUR T1 - Application of systems pharmacology to explore mechanisms of hepatotoxicity. AN - 1615740425; 25336266 AB - Advances in systems biology have allowed the development of a highly characterized systems pharmacology model to study mechanisms of drug-induced hepatotoxicity. In this issue of CPT, Yang et al. describe a model, DILIsym, used to characterize mechanisms of hepatotoxicity of troglitazone. Their modeling approach has provided new insight into troglitazone-induced hepatotoxicity in humans but is not associated with hepatotoxicity in rats, consistent with preclinical data for this drug. JF - Clinical pharmacology and therapeutics AU - Shon, J AU - Abernethy, D R AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 536 EP - 537 VL - 96 IS - 5 KW - Bile Acids and Salts KW - 0 KW - Chromans KW - Hypoglycemic Agents KW - Thiazolidinediones KW - troglitazone KW - I66ZZ0ZN0E KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Humans KW - Male KW - Chromans -- toxicity KW - Chemical and Drug Induced Liver Injury -- etiology KW - Hypoglycemic Agents -- toxicity KW - Thiazolidinediones -- toxicity KW - Bile Acids and Salts -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1615740425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Application+of+systems+pharmacology+to+explore+mechanisms+of+hepatotoxicity.&rft.au=Shon%2C+J%3BAbernethy%2C+D+R&rft.aulast=Shon&rft.aufirst=J&rft.date=2014-11-01&rft.volume=96&rft.issue=5&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2014.167 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-23 N1 - Date created - 2014-10-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment On: Clin Pharmacol Ther. 2014 Nov;96(5):589-98 [25068506] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/clpt.2014.167 ER - TY - JOUR T1 - Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene. AN - 1614694870; 25245543 AB - The polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene (BP) is thought to bind covalently to DNA, through metabolism by cytochrome P450 1A1 (CYP1A1) and CYP1B1, and other enzymes, to form r7, t8, t9-trihydroxy-c-10-(N(2)-deoxyguanosyl)-7,8,9,10-tetrahydro-benzo[a]-pyrene (BPdG). Evaluation of RNA expression data, to understand the contribution of different metabolic enzymes to BPdG formation, is typically presented as fold-change observed upon BP exposure, leaving the actual number of RNA transcripts unknown. Here, we have quantified RNA copies/ng cDNA (RNA cpn) for CYP1A1 and CYP1B1, as well as quinone oxidoreductase 1 (NQO1), which may reduce formation of BPdG adducts, using primary normal human mammary epithelial cell (NHMEC) strains, and the MCF-7 breast cancer cell line. In unexposed NHMECs, basal RNA cpn values were 58-836 for CYP1A1, 336-5587 for CYP1B1 and 5943-40112 for NQO1. In cells exposed to 4.0 µM BP for 12h, RNA cpn values were 251-13234 for CYP1A1, 4133-57078 for CYP1B1 and 4456-55887 for NQO1. There were 3.5 (mean, range 0.2-15.8) BPdG adducts/10(8) nucleotides in the NHMECs (n = 16), and 790 in the MCF-7s. In the NHMECs, BP-induced CYP1A1 RNA cpn was highly associated with BPdG (P = 0.002), but CYP1B1 and NQO1 were not. Western blots of four NHMEC strains, chosen for different levels of BPdG adducts, showed a linear correlation between BPdG and CYP1A1, but not CYP1B1 or NQO1. Ethoxyresorufin-O-deethylase (EROD) activity, which measures CYP1A1 and CYP1B1 together, correlated with BPdG, but NQO1 activity did not. Despite more numerous levels of CYP1B1 and NQO1 RNA cpn in unexposed and BP-exposed NHMECs and MCF-7cells, BPdG formation was only correlated with induction of CYP1A1 RNA cpn. The higher level of BPdG in MCF-7 cells, compared to NHMECs, may have been due to a much increased induction of CYP1A1 and EROD. Overall, BPdG correlation was observed with CYP1A1 protein and CYP1A1/1B1 enzyme activity, but not with CYP1B1 or NQO1 protein, or NQO1 enzyme activity. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society 2014. JF - Mutagenesis AU - Divi, Rao L AU - Lindeman, Tracey L Einem AU - Shockley, Marie E AU - Keshava, Channa AU - Weston, Ainsley AU - Poirier, Miriam C AD - Carcinogen-DNA Interactions Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20817, USA, National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA and Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA and. ; Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. ; Carcinogen-DNA Interactions Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20817, USA, National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA and Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. poirierm@exchange.nih.gov. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 409 EP - 417 VL - 29 IS - 6 KW - DNA Adducts KW - 0 KW - RNA, Messenger KW - Benzo(a)pyrene KW - 3417WMA06D KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1B1 KW - NAD(P)H Dehydrogenase (Quinone) KW - EC 1.6.5.2 KW - NQO1 protein, human KW - Index Medicus KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Cytochrome P-450 CYP1B1 -- metabolism KW - Humans KW - MCF-7 Cells KW - NAD(P)H Dehydrogenase (Quinone) -- metabolism KW - RNA, Messenger -- genetics KW - Epithelial Cells -- metabolism KW - Mammary Glands, Human -- cytology KW - Cytochrome P-450 CYP1A1 -- genetics KW - Epithelial Cells -- drug effects KW - Benzo(a)pyrene -- toxicity KW - Cytochrome P-450 CYP1A1 -- metabolism KW - DNA Adducts -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1614694870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Correlation+between+CYP1A1+transcript%2C+protein+level%2C+enzyme+activity+and+DNA+adduct+formation+in+normal+human+mammary+epithelial+cell+strains+exposed+to+benzo%5Ba%5Dpyrene.&rft.au=Divi%2C+Rao+L%3BLindeman%2C+Tracey+L+Einem%3BShockley%2C+Marie+E%3BKeshava%2C+Channa%3BWeston%2C+Ainsley%3BPoirier%2C+Miriam+C&rft.aulast=Divi&rft.aufirst=Rao&rft.date=2014-11-01&rft.volume=29&rft.issue=6&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgeu049 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-18 N1 - Date created - 2014-10-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Carcinogenesis. 2000 Jul;21(7):1281-9 [10874004] Discov Med. 2012 Oct;14(77):283-8 [23114584] Cancer Res. 2001 Dec 1;61(23):8465-9 [11731429] Environ Mol Mutagen. 2002;39(2-3):201-7 [11921190] Carcinogenesis. 2002 Dec;23(12):2043-9 [12507927] Methods Enzymol. 2004;382:115-44 [15047100] Nature. 1974 Nov 22;252(5481):326-8 [4473724] In Vitro. 1980 May;16(5):415-25 [6993343] Br J Cancer. 1981 Jul;44(1):24-34 [6789855] Nature. 1983 Jun 9-15;303(5917):468-72 [6304528] Prog Clin Biol Res. 1989;298:3-15 [2501799] Nucleic Acids Res. 1991 Aug 11;19(15):4293 [1870982] Carcinogenesis. 1991 Oct;12(10):1939-44 [1934274] Carcinogenesis. 1994 Feb;15(2):247-52 [8313515] Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8413-7 [8078896] Br J Cancer. 1998 Mar;77(5):709-19 [9514048] Carcinogenesis. 1998 Nov;19(11):1949-53 [9855008] Chem Res Toxicol. 1999 Jul;12(7):623-9 [10409402] Mol Pharmacol. 1999 Oct;56(4):760-7 [10496959] Mar Biotechnol (NY). 2004 Jul-Aug;6(4):307-11 [15546046] Cancer Lett. 2005 Apr 28;221(2):213-24 [15808407] Toxicol Lett. 2006 Mar 15;162(1):3-15 [16321483] Mol Pharmacol. 2006 Apr;69(4):1103-14 [16377763] Arch Environ Health. 2004 Dec;59(12):640-9 [16789472] Toxicol Lett. 2006 Dec 15;167(3):173-82 [17049425] Chem Res Toxicol. 2007 Mar;20(3):424-31 [17295519] Carcinogenesis. 2007 Mar;28(3):611-24 [16973675] Epidemiology. 2007 May;18(3):373-82 [17435448] Cancer. 2007 Jun 15;109(12 Suppl):2667-711 [17503436] Drug Metab Dispos. 2007 Jul;35(7):1009-16 [17431034] Carcinogenesis. 2007 Jul;28(7):1426-9 [17277232] Chem Res Toxicol. 2008 Jan;21(1):70-83 [18052394] Environ Mol Mutagen. 2009 Mar;50(2):134-44 [19152381] Int J Cancer. 2010 Nov 15;127(10):2334-50 [20127859] IARC Monogr Eval Carcinog Risks Hum. 2010;92:1-853 [21141735] Breast Cancer Res Treat. 2011 Sep;129(2):477-84 [21452020] Int J Environ Res Public Health. 2011 Jul;8(7):2675-91 [21845152] Toxicol Lett. 2012 Sep 3;213(2):160-6 [22759596] Carcinogenesis. 2000 Jul;21(7):1433-40 [10874023] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/geu049 ER - TY - JOUR T1 - Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production and Lactobacillus species growth in a defined medium simulating vaginal secretions. AN - 1566819655; 25135489 AB - Lactobacillus species are commensal with the healthy vaginal environment and inhibit the growth of many pathogenic bacteria in the vaginal tract by a variety of mechanisms, such as the production of hydrogen peroxide, organic acids, and antimicrobial substances. Simulation of the vaginal environment is crucial for proper investigation of the effects of Lactobacillus species on pathogenic bacteria. In this study, we modified a medium used to simulate vaginal secretions to improve the growth of toxic shock syndrome toxin-1 (TSST-1)-producing Staphylococcus aureus clinical strains and Lactobacillus species so that interactions between these bacteria may be examined. A medium consisting of basal salts, vitamins, albumin, glycogen, mucin, urea, sodium bicarbonate, polyoxyethylene sorbitan monolaurate, and amino acids supported the growth of S. aureus and the production of TSST-1 as determined by Western analysis. Improved growth of the Lactobacillus species was seen when this same medium was supplemented with manganese chloride, sodium acetate, and an increase in glucose concentration. However, growth of S. aureus in the supplemented medium resulted in reduced levels of TSST-1. Production of TSST-1 was not detected in a medium routinely used for the growth of Lactobacillus species although S. aureus growth was not inhibited. The development of an improved genital tract secretion medium provides a more authentic environment in which to study the interactions of Lactobacillus species and vaginal pathogens, such as S. aureus. Published by Elsevier B.V. JF - Journal of microbiological methods AU - Stingley, Robin L AU - Liu, Huanli AU - Mullis, Lisa B AU - Elkins, Christopher A AU - Hart, Mark E AD - Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Office of Regulatory Affairs, Arkansas Regional Laboratories, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, USA. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: mark.hart@fda.hhs.gov. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 57 EP - 66 VL - 106 KW - Bacterial Toxins KW - 0 KW - Culture Media KW - Enterotoxins KW - Superantigens KW - enterotoxin F, Staphylococcal KW - Index Medicus KW - In vitro growth KW - Lactobacillus species KW - TSST-1 KW - Menstrual toxic shock syndrome KW - Staphylococcus aureus KW - Simulated genital tract secretion medium KW - Vagina -- chemistry KW - Humans KW - Body Fluids -- chemistry KW - Female KW - Staphylococcus aureus -- physiology KW - Lactobacillus -- physiology KW - Enterotoxins -- secretion KW - Staphylococcus aureus -- growth & development KW - Microbial Interactions KW - Lactobacillus -- growth & development KW - Staphylococcus aureus -- metabolism KW - Culture Media -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566819655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+microbiological+methods&rft.atitle=Staphylococcus+aureus+toxic+shock+syndrome+toxin-1+%28TSST-1%29+production+and+Lactobacillus+species+growth+in+a+defined+medium+simulating+vaginal+secretions.&rft.au=Stingley%2C+Robin+L%3BLiu%2C+Huanli%3BMullis%2C+Lisa+B%3BElkins%2C+Christopher+A%3BHart%2C+Mark+E&rft.aulast=Stingley&rft.aufirst=Robin&rft.date=2014-11-01&rft.volume=106&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+microbiological+methods&rft.issn=1872-8359&rft_id=info:doi/10.1016%2Fj.mimet.2014.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-03 N1 - Date created - 2014-09-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.mimet.2014.08.002 ER - TY - JOUR T1 - Comparative cytotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells in culture. AN - 1566408512; 24522958 AB - The use of silver nanoparticles in food, food contact materials, dietary supplements and cosmetics has increased significantly owing to their antibacterial and antifungal properties. As a consequence, the need for validated rapid screening methods to assess their toxicity is necessary to ensure consumer safety. This study evaluated two widely used in vitro cell culture models, human liver HepG2 cells and human colon Caco2 cells, as tools for assessing the potential cytotoxicity of food- and cosmetic-related nanoparticles. The two cell culture models were utilized to compare the potential cytotoxicity of 20-nm silver. The average size of the silver nanoparticle determined by our transmission electron microscopy (TEM) analysis was 20.4 nm. The dynamic light scattering (DLS) analysis showed no large agglomeration of the silver nanoparticles. The concentration of the 20-nm silver solution determined by our inductively coupled plasma-mass spectrometry (ICP-MS) analysis was 0.962 mg ml(-1) . Our ICP-MS and TEM analysis demonstrated the uptake of 20-nm silver by both HepG2 and Caco2 cells. Cytotoxicity, determined by the Alamar Blue reduction assay, was evaluated in the nanosilver concentration range of 0.1 to 20 µg ml(-1) . Significant concentration-dependent cytotoxicity of the nanosilver in HepG2 cells was observed in the concentration range of 1 to 20 µg ml(-1) and at a higher concentration range of 10 to 20 µg ml(-1) in Caco2 cells compared with the vehicle control. A concentration-dependent decrease in dsDNA content was observed in both cell types exposed to nanosilver but not controls, suggesting an increase in DNA damage. The DNA damage was observed in the concentration range of 1 to 20 µg ml(-1) . Nanosilver-exposed HepG2 and Caco2 cells showed no cellular oxidative stress, determined by the dichlorofluorescein assay, compared with the vehicle control in the concentration range used in this study. A concentration-dependent decrease in mitochondria membrane potential in both nanosilver exposed cell types suggested increased mitochondria injury compared with the vehicle control. The mitochondrial injury in HepG2 cells was significant in the concentration range of 1 to 20 µg ml(-1) , but in Caco2 cells it was significant at a higher concentration range of 10 to 20 µg ml(-1) . These results indicated that HepG2 cells were more sensitive to nanosilver exposure than Caco2 cells. It is generally believed that cellular oxidative stress induces cytotoxicity of nanoparticles. However, in this study we did not detect any nanosilver-induced oxidative stress in either cell type at the concentration range used in this study. Our results suggest that cellular oxidative stress did not play a major role in the observed cytotoxicity of nanosilver in HepG2 and Caco2 cells and that a different mechanism of nanosilver-induced mitochondrial injury leads to the cytotoxicity. The HepG2 and Caco2 cells used this study appear to be targets for silver nanoparticles. The results of this study suggest that the differences in the mechanisms of toxicity induced by nanosilver may be largely as a consequence of the type of cells used. This differential rather than universal response of different cell types exposed to nanoparticles may play an important role in the mechanism of their toxicity. In summary, the results of this study indicate that the widely used in vitro models, HepG2 and Caco2 cells in culture, are excellent systems for screening cytotoxicity of silver nanoparticles. These long established cell culture models and simple assays used in this study can provide useful toxicity and mechanistic information that can help to better inform safety assessments of food- and cosmetic-related silver nanoparticles. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Sahu, Saura C AU - Zheng, Jiwen AU - Graham, Lesley AU - Chen, Lynn AU - Ihrie, John AU - Yourick, Jeffrey J AU - Sprando, Robert L AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD, 20708, USA. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1155 EP - 1166 VL - 34 IS - 11 KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - nanosilver KW - HepG2 cells KW - Caco2 cells KW - cytotoxicity KW - nanoparticles KW - mitochondrial injury KW - silver nanoparticles KW - oxidative stress KW - Microscopy, Electron, Transmission KW - Hep G2 Cells KW - Dose-Response Relationship, Drug KW - Humans KW - Mitochondria -- drug effects KW - Oxidative Stress -- drug effects KW - Caco-2 Cells KW - DNA Damage -- drug effects KW - Metal Nanoparticles -- toxicity KW - Silver -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566408512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Comparative+cytotoxicity+of+nanosilver+in+human+liver+HepG2+and+colon+Caco2+cells+in+culture.&rft.au=Sahu%2C+Saura+C%3BZheng%2C+Jiwen%3BGraham%2C+Lesley%3BChen%2C+Lynn%3BIhrie%2C+John%3BYourick%2C+Jeffrey+J%3BSprando%2C+Robert+L&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2014-11-01&rft.volume=34&rft.issue=11&rft.spage=1155&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.2994 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-19 N1 - Date created - 2014-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.2994 ER - TY - JOUR T1 - Comparative genotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by a flow cytometric in vitro micronucleus assay. AN - 1566407331; 25224830 AB - Two widely used in vitro cell culture models, human liver HepG2 cells and human colon Caco2 cells, and flow cytometry techniques were evaluated as tools for rapid screening of potential genotoxicity of food-related nanosilver. Comparative genotoxic potential of 20 nm silver was evaluated in HepG2 and Caco2 cell cultures by a flow cytometric-based in vitro micronucleus assay. The nanosilver, characterized by the dynamic light scattering, transmission electron microscopy and inductively coupled plasma-mass spectrometry analysis, showed no agglomeration of the silver nanoparticles. The inductively coupled plasma-mass spectrometry and transmission electron microscopy analysis demonstrated the uptake of 20 nm silver by both cell types. The 20 nm silver exposure of HepG2 cells increased the concentration-dependent micronucleus formation sevenfold at 10 µg ml(-1) concentration in attached cell conditions and 1.3-fold in cell suspension conditions compared to the vehicle controls. However, compared to the vehicle controls, the 20 nm silver exposure of Caco2 cells increased the micronucleus formation 1.2-fold at a concentration of 10 µg ml(-1) both in the attached cell conditions as well as in the cell suspension conditions. Our results of flow cytometric in vitro micronucleus assay appear to suggest that the HepG2 cells are more susceptible to the nanosilver-induced micronucleus formation than the Caco2 cells compared to the vehicle controls. However, our results also suggest that the widely used in vitro models, HepG2 and Caco2 cells and the flow cytometric in vitro micronucleus assay are valuable tools for the rapid screening of genotoxic potential of nanosilver and deserve more careful evaluation. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Sahu, Saura C AU - Njoroge, Joyce AU - Bryce, Steven M AU - Yourick, Jeffrey J AU - Sprando, Robert L AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, 20708, USA. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1226 EP - 1234 VL - 34 IS - 11 KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - nanosilver KW - micronucleus KW - HepG2 cells KW - Caco2 cells KW - genotoxicity KW - flow cytometry KW - Nanoparticles KW - silver nanoparticles KW - Liver -- cytology KW - Micronucleus Tests KW - Hep G2 Cells KW - Liver -- drug effects KW - Humans KW - Colon -- drug effects KW - Colon -- cytology KW - Apoptosis -- drug effects KW - Toxicity Tests KW - Flow Cytometry KW - Caco-2 Cells KW - Silver -- toxicity KW - Nanoparticles -- toxicity KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566407331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Comparative+genotoxicity+of+nanosilver+in+human+liver+HepG2+and+colon+Caco2+cells+evaluated+by+a+flow+cytometric+in+vitro+micronucleus+assay.&rft.au=Sahu%2C+Saura+C%3BNjoroge%2C+Joyce%3BBryce%2C+Steven+M%3BYourick%2C+Jeffrey+J%3BSprando%2C+Robert+L&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2014-11-01&rft.volume=34&rft.issue=11&rft.spage=1226&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3065 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-19 N1 - Date created - 2014-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3065 ER - TY - JOUR T1 - EU alerting and reporting systems for potential chemical public health threats and hazards. AN - 1564606917; 25023642 AB - A number of European and international IT platforms are used to notify competent authorities of new potential chemical exposures. Recently the European Parliament and the Council of European Union adopted new legislation that aims to improve the co-ordinated response to cross border health threats (Decision 1082/2013/EU). The Decision, inter alia, sets provisions on notification, ad hoc monitoring and coordination of public health measures following serious cross border threats to health from biological, chemical and environmental events as well as events that have an unknown origin. The legal instrument applies to all European Union Member States and is comparable to the International Health Regulations in its content, requirements and adoption of a multiple hazards approach. An inter-sectoral and multidisciplinary response to events with potentially dangerous cross border exposure pathways is often required. For example, European Poisons Centres may be aware of cases of toxic exposure to a product and, in parallel, trading standards may be aware of the same product due to a breach of consumer product standards. Whilst both cases would have been recorded for separate purposes in different alerting systems, they relate to the same exposure pathway; therefore a process for linking these records would allow a more robust approach to risk assessment and risk mitigation. The Decision seeks to reconcile this issue for serious threats by linking relevant platforms into one overarching higher level risk management IT platform called the Early Warning Response System (EWRS). This system will serve to link other sectors within the European Commission (EC) to public health (e.g. medicines), as well as other EU agencies and international bodies via co-notification features. Other European alert systems will be linked to EWRS to facilitate information sharing at both the assessment and management levels. This paper provides a timely overview of the main systems run by the EC and other international organisations that provide alerts following chemical incidents that have, or may have, the potential to affect public health. The advantages and further considerations of linking these different systems and sectors are also highlighted. Recommendations are made with the purpose of ensuring that modifications to these systems made to satisfy with EU legislation enable a more timely coordinated response and greater awareness of events in Europe, thereby reducing the public health impact from chemical exposures. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Orford, R AU - Crabbe, H AU - Hague, C AU - Schaper, A AU - Duarte-Davidson, R AD - International Research and Development Group, Centre for Radiation, Chemicals and Environmental Hazards, Public Health England, UK. Electronic address: Rob.Orford@phe.gov.uk. ; International Research and Development Group, Centre for Radiation, Chemicals and Environmental Hazards, Public Health England, UK. ; GIZ-Nord Poisons Centre, Goettingen, Germany. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 15 EP - 25 VL - 72 KW - Street Drugs KW - 0 KW - Index Medicus KW - Hazards KW - Chemicals KW - EWRS KW - RASCHEM KW - Alerting KW - Reporting KW - Food Contamination -- prevention & control KW - Adverse Drug Reaction Reporting Systems -- legislation & jurisprudence KW - Accidents, Occupational -- prevention & control KW - European Union KW - Chemical Hazard Release -- legislation & jurisprudence KW - International Cooperation KW - Humans KW - Food Contamination -- legislation & jurisprudence KW - Street Drugs -- legislation & jurisprudence KW - Accidents, Occupational -- legislation & jurisprudence KW - Chemical Hazard Release -- prevention & control KW - Risk Assessment KW - Public Health -- methods KW - Public Health -- legislation & jurisprudence KW - Public Health -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1564606917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=EU+alerting+and+reporting+systems+for+potential+chemical+public+health+threats+and+hazards.&rft.au=Orford%2C+R%3BCrabbe%2C+H%3BHague%2C+C%3BSchaper%2C+A%3BDuarte-Davidson%2C+R&rft.aulast=Orford&rft.aufirst=R&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.05.006 ER - TY - JOUR T1 - Responding to biological incidents--what are the current issues in remediation of the contaminated environment? AN - 1552808032; 24530001 AB - Since 2000 there have been a number of biological incidents resulting in environmental contamination with Bacillus anthracis, the causative agent of anthrax. These incidents include the US anthrax attacks in 2001, the US and UK drumming incidents in 2006-2008 and more recently, anthrax contamination of heroin in 2009/2010 and 2012/2013. Remediation techniques used to return environments to normal have varied between incidents, with different decontamination technologies being employed. Many factors need to be considered before a remediation strategy or recovery option can be implemented, including; cost, time (length of application), public perception of risk, and sampling strategies (and results) to name a few. These incidents have demonstrated that consolidated guidance for remediating biologically contaminated environments in the aftermath of a biological incident was required. The UK Recovery Handbook for Biological Incidents (UKRHBI) is a project led by Public Health England (PHE), formerly the Health Protection Agency (HPA) to provide guidance and advice on how to remediate the environment following a biological incident or outbreak of infection, and is expected to be published in 2015. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved. JF - Environment international AU - Pottage, T AU - Goode, E AU - Wyke, S AU - Bennett, A M AD - Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK. Electronic address: Thomas.pottage@phe.gov.uk. ; Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK. ; Centre for Radiation, Chemicals and Environmental Hazards, Public Health England, Chilton OX11 0RQ, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 133 EP - 139 VL - 72 KW - Index Medicus KW - Remediation KW - Decontamination KW - Anthrax KW - Bioterrorism KW - Bacillus anthracis KW - Bacillus anthracis -- isolation & purification KW - Disaster Planning -- economics KW - Humans KW - Delivery of Health Care KW - Anthrax -- pathology KW - Anthrax -- prevention & control KW - Anthrax -- microbiology KW - Bacillus anthracis -- physiology KW - Risk Assessment KW - Decontamination -- methods KW - Decontamination -- economics KW - Biohazard Release -- prevention & control KW - Environmental Restoration and Remediation -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552808032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Responding+to+biological+incidents--what+are+the+current+issues+in+remediation+of+the+contaminated+environment%3F&rft.au=Pottage%2C+T%3BGoode%2C+E%3BWyke%2C+S%3BBennett%2C+A+M&rft.aulast=Pottage&rft.aufirst=T&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.01.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.01.018 ER - TY - JOUR T1 - Recent advances to address European Union Health Security from cross border chemical health threats. AN - 1552808003; 24679379 AB - The European Union (EU) Decision (1082/2013/EU) on serious cross border threats to health was adopted by the European Parliament in November 2013, in recognition of the need to strengthen the capacity of Member States to coordinate the public health response to cross border threats, whether from biological, chemical, environmental events or events which have an unknown origin. Although mechanisms have been in place for years for reporting cross border health threats from communicable diseases, this has not been the case for incidents involving chemicals and/or environmental events. A variety of collaborative EU projects have been funded over the past 10 years through the Health Programme to address gaps in knowledge on health security and to improve resilience and response to major incidents involving chemicals. This paper looks at the EU Health Programme that underpins recent research activities to address gaps in resilience, planning, responding to and recovering from a cross border chemical incident. It also looks at how the outputs from the research programme will contribute to improving public health management of transnational incidents that have the potential to overwhelm national capabilities, putting this into context with the new requirements as the Decision on serious cross border threats to health as well as highlighting areas for future development. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved. JF - Environment international AU - Duarte-Davidson, R AU - Orford, R AU - Wyke, S AU - Griffiths, M AU - Amlôt, R AU - Chilcott, R AD - Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. Electronic address: raquel.duarte-davidson@phe.gov.uk. ; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. ; Microbial Risk Assessment & Behavioural Science, Emergency Response Department, Public Health England, UK. ; Department of Pharmacy, University of Hertfordshire, Hatfield, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 3 EP - 14 VL - 72 KW - Index Medicus KW - CBRN KW - Cross border health threats KW - Alerting and notification KW - Chemical incident KW - Emergency response KW - Public health risk assessment and management KW - Radioactive Hazard Release -- legislation & jurisprudence KW - Environmental Pollution -- prevention & control KW - Health Planning KW - European Union KW - Chemical Hazard Release -- legislation & jurisprudence KW - Environmental Pollution -- legislation & jurisprudence KW - Humans KW - Biohazard Release -- prevention & control KW - Chemical Hazard Release -- prevention & control KW - Biohazard Release -- legislation & jurisprudence KW - Risk Assessment KW - Radioactive Hazard Release -- prevention & control KW - Public Health -- legislation & jurisprudence KW - Safety Management -- trends KW - Safety Management -- legislation & jurisprudence KW - Public Health -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552808003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Recent+advances+to+address+European+Union+Health+Security+from+cross+border+chemical+health+threats.&rft.au=Duarte-Davidson%2C+R%3BOrford%2C+R%3BWyke%2C+S%3BGriffiths%2C+M%3BAml%C3%B4t%2C+R%3BChilcott%2C+R&rft.aulast=Duarte-Davidson&rft.aufirst=R&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.01.003 ER - TY - JOUR T1 - Development of a risk-based prioritisation methodology to inform public health emergency planning and preparedness in case of accidental spill at sea of hazardous and noxious substances (HNS). AN - 1552807995; 24953645 AB - Hazardous and noxious chemicals are increasingly being transported by sea. Current estimates indicate some 2000 hazardous and noxious substances (HNS) are carried regularly by sea with bulk trade of 165milliontonnes per year worldwide. Over 100 incidents involving HNS have been reported in EU waters. Incidents occurring in a port or coastal area can have potential and actual public health implications. A methodology has been developed for prioritisation of HNS, based upon potential public health risks. The work, undertaken for the Atlantic Region Pollution Response programme (ARCOPOL), aims to provide information for incident planning and preparedness. HNS were assessed using conventional methodology based upon acute toxicity, behaviour and reactivity. Tonnage was used as a proxy for likelihood, although other factors such as shipping frequency and local navigation may also contribute. Analysis of 350 individual HNS identified the highest priority HNS as being those that present an inhalation risk. Limitations were identified around obtaining accurate data on HNS handled on a local and regional level due to a lack of port records and also political and commercial confidentiality issues. To account for this the project also developed a software tool capable of combining chemical data from the study with user defined shipping data to be used by operators to produce area-specific prioritisations. In conclusion a risk prioritisation matrix has been developed to assess the acute risks to public health from the transportation of HNS. Its potential use in emergency planning and preparedness is discussed. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Harold, P D AU - de Souza, A S AU - Louchart, P AU - Russell, D AU - Brunt, H AD - Public Health England CRCE, C/O Cardiff Metropolitan University Western Avenue, Cardiff, Wales, United Kingdom. Electronic address: paul.harold@phe.gov.uk. ; Public Health Wales, Wales, United Kingdom. ; Pembrokeshire County Council, Wales, United Kingdom. ; Public Health England CRCE, C/O Cardiff Metropolitan University Western Avenue, Cardiff, Wales, United Kingdom. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 157 EP - 163 VL - 72 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Risk prioritisation KW - Emergency planning and preparedness KW - Public health risk KW - HNS incidents KW - Software KW - Oceans and Seas KW - Humans KW - Risk Assessment KW - Hazardous Substances -- chemistry KW - Civil Defense -- methods KW - Public Health KW - Hazardous Substances -- metabolism KW - Chemical Hazard Release KW - Disaster Planning -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Development+of+a+risk-based+prioritisation+methodology+to+inform+public+health+emergency+planning+and+preparedness+in+case+of+accidental+spill+at+sea+of+hazardous+and+noxious+substances+%28HNS%29.&rft.au=Harold%2C+P+D%3Bde+Souza%2C+A+S%3BLouchart%2C+P%3BRussell%2C+D%3BBrunt%2C+H&rft.aulast=Harold&rft.aufirst=P&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.05.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.05.012 ER - TY - JOUR T1 - Recent developments in assessing and managing serious health threats. AN - 1552807947; 24970671 JF - Environment international AU - Duarte-Davidson, R AU - Griffiths, M AU - Wyke, S AU - Bradley, Naima AD - Public Health England, Centre for Radiation, Chemicals and Environmental Hazards, Oxon, UK. Electronic address: raquel.duarte-davidson@phe.gov.uk. ; Public Health England, Centre for Radiation, Chemicals and Environmental Hazards, Oxon, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1 EP - 2 VL - 72 KW - Index Medicus KW - Humans KW - Biohazard Release -- prevention & control KW - Chemical Hazard Release -- prevention & control KW - Radioactive Hazard Release -- prevention & control KW - Public Health -- legislation & jurisprudence KW - Public Health -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Recent+developments+in+assessing+and+managing+serious+health+threats.&rft.au=Duarte-Davidson%2C+R%3BGriffiths%2C+M%3BWyke%2C+S%3BBradley%2C+Naima&rft.aulast=Duarte-Davidson&rft.aufirst=R&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.06.001 ER - TY - JOUR T1 - Assessing and improving cross-border chemical incident preparedness and response across Europe. AN - 1552807922; 24768281 AB - Good practices in emergency preparedness and response for chemical incidents include practices specific to the different functions of exposure assessment (e.g., within the monitoring function, the use of mobile monitoring equipment; within the modelling function, the use of rapid dispersion models with integrated mapping software) and generic practices to engage incident response stakeholders to maximise exposure assessment capabilities (e.g., sharing protocols and pre-prepared information and multi-agency training and exercising). Such practices can optimise cross-border collaboration. A wide range of practices have been implemented across MSs during chemical incident response, particularly during incidents that have cross-border and trans-boundary impacts. This paper proposes a self-assessment methodology to enable MSs, or organisations within MSs, to examine exposure assessment capabilities and communication pathways between exposure assessors and public health risk assessors. Where gaps exist, this methodology provides links to good practices that could improve response, communication and collaboration across local, regional and national borders. A fragmented approach to emergency preparedness for chemical incidents is a major obstacle to improving cross-border exposure assessment. There is no one existing body or structure responsible for all aspects of chemical incident preparedness and response in the European Union. Due to the range of different organisations and networks involved in chemical incident response, emergency preparedness needs to be drawn together. A number of recommendations are proposed, including the use of networks of experts which link public health risk assessors with experts in exposure assessment, in order to coordinate and improve chemical incident emergency preparedness. The EU's recent Decision on serious cross-border threats to health aims to facilitate MSs' compliance with the International Health Regulations, which require reporting and communication regarding significant chemical incidents. This provides a potential route to build on in order to improve chemical incident preparedness and response across Europe. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Stewart-Evans, James AU - Hall, Lisbeth AU - Czerczak, Slawomir AU - Manley, Kevin AU - Dobney, Alec AU - Hoffer, Sally AU - Pałaszewska-Tkacz, Anna AU - Jankowska, Agnieszka AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Institute of Population Health, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK. Electronic address: james.stewart-evans@phe.gov.uk. ; Centre for Environmental Safety and Security, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. ; Chemical Safety Department, Nofer Institute of Occupational Medicine Poland, 91-348 Lodz, 8 Sw. Teresy Street, Poland. ; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Citygate, Gallowgate, Newcastle Upon Tyne NE1 4WH, UK. ; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, St. Philips Place, Birmingham B3 2PW, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 30 EP - 36 VL - 72 KW - Index Medicus KW - Risk assessment KW - Emergency planning KW - Chemical incident KW - Emergency preparedness KW - Emergency response KW - Exposure assessment KW - Environmental Pollution -- prevention & control KW - Environmental Monitoring KW - European Union KW - Humans KW - Health Services Needs and Demand -- legislation & jurisprudence KW - Self-Assessment KW - Chemical Hazard Release -- legislation & jurisprudence KW - Disaster Planning -- standards KW - Chemical Hazard Release -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Assessing+and+improving+cross-border+chemical+incident+preparedness+and+response+across+Europe.&rft.au=Stewart-Evans%2C+James%3BHall%2C+Lisbeth%3BCzerczak%2C+Slawomir%3BManley%2C+Kevin%3BDobney%2C+Alec%3BHoffer%2C+Sally%3BPa%C5%82aszewska-Tkacz%2C+Anna%3BJankowska%2C+Agnieszka&rft.aulast=Stewart-Evans&rft.aufirst=James&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.03.012 ER - TY - JOUR T1 - The importance of evaluating the physicochemical and toxicological properties of a contaminant for remediating environments affected by chemical incidents. AN - 1552807668; 24874001 AB - In the event of a major chemical incident or accident, appropriate tools and technical guidance need to be available to ensure that a robust approach can be adopted for developing a remediation strategy. Remediation and restoration strategies implemented in the aftermath of a chemical incident are a particular concern for public health. As a result an innovative methodology has been developed to help design an effective recovery strategy in the aftermath of a chemical incident that has been developed; the UK Recovery Handbook for Chemical Incidents (UKRHCI). The handbook consists of a six-step decision framework and the use of decision trees specifically designed for three different environments: food production systems, inhabited areas and water environments. It also provides a compendium of evidence-based recovery options (techniques or methods for remediation) that should be selected in relation to their efficacy for removing contaminants from the environment. Selection of effective recovery options in this decision framework involves evaluating the physicochemical and toxicological properties of the chemical(s) involved. Thus, the chemical handbook includes a series of tables with relevant physicochemical and toxicological properties that should be assessed in function of the environment affected. It is essential that the physicochemical properties of a chemical are evaluated and interpreted correctly during the development of a remedial plan in the aftermath of a chemical incident to ensure an effective remedial response. This paper presents a general overview of the key physicochemical and toxicological properties of chemicals that should be evaluated when developing a recovery strategy. Information on how physicochemical properties have impacted on previous remedial responses reported in the literature is also discussed and a number of challenges for remediation are highlighted to include the need to develop novel approaches to remediate sites contaminated by mixtures of chemicals as well as methods for interpreting chemical reactions in different environmental matrices to include how climate change may affect the speciation and mobility of chemicals in the environment. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Wyke, S AU - Peña-Fernández, A AU - Brooke, N AU - Duarte-Davidson, R AD - Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. Electronic address: Stacey.wyke@phe.gov.uk. ; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 109 EP - 118 VL - 72 KW - Gases KW - 0 KW - Hazardous Substances KW - Soil KW - Water KW - 059QF0KO0R KW - Index Medicus KW - Environmental decontamination KW - Physicochemical and toxicological properties KW - Chemical incident KW - Recovery and restoration KW - Gases -- chemistry KW - Viscosity KW - Solubility KW - Food Chain KW - Humans KW - Water -- chemistry KW - Chemical Phenomena KW - Soil -- chemistry KW - Surface Properties KW - Hazardous Substances -- chemistry KW - Environmental Restoration and Remediation KW - Hazardous Substances -- metabolism KW - Chemical Hazard Release KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=The+importance+of+evaluating+the+physicochemical+and+toxicological+properties+of+a+contaminant+for+remediating+environments+affected+by+chemical+incidents.&rft.au=Wyke%2C+S%3BPe%C3%B1a-Fern%C3%A1ndez%2C+A%3BBrooke%2C+N%3BDuarte-Davidson%2C+R&rft.aulast=Wyke&rft.aufirst=S&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.05.002 ER - TY - JOUR T1 - Preparedness for a major incident: creation of an epidemiology protocol for a health protection register in England. AN - 1552807650; 24928282 AB - Large incidents and natural disasters are on the increase globally. They can have a major impact lasting many years or decades; and can affect large groups of people including those that are more susceptible to adverse consequences. Following a major incident, it may be considered necessary to establish a register of those people affected by the incident to provide appropriate advice on relevant immediate and longer-term public health interventions that may be required, provide reassurance to the public that their care is paramount, to reassure the worried well to avoid them inappropriately overwhelming local services, and to facilitate epidemiological investigations. Arrangements for the prompt follow-up of populations after large incidents or disasters have been agreed in England and a protocol for establishing a register of individuals potentially affected by a large incident has been developed. It is important for countries to have a protocol for implementing a health register if the circumstances require one to be in place, and are supported by Public Health Authorities. Health registers facilitate the initial descriptive epidemiology of exposure and provide the opportunity of carrying out long term analytical studies on the affected population. Such epidemiological studies provide a greater understanding of the impact that a large incident can have on health, which in turn helps in the planning of health care provision. Registers can also assist more directly in providing access to individuals in need of physical and mental health interventions. The challenge that still remains is to formally pilot the register in the field and refine it based on that experience. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Close, R M AU - Maguire, H AU - Etherington, G AU - Brewin, C R AU - Fong, K AU - Saliba, V AU - Barker, R M AU - Leonardi, G S AD - Department of Epidemiology, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK; Field Epidemiology Training Programme (FETP), Public Health England, UK; European Programme for Intervention Epidemiology Training, ECDC, Stockholm, Sweden. Electronic address: rebecca.close@phe.gov.uk. ; European Programme for Intervention Epidemiology Training, ECDC, Stockholm, Sweden; Field Epidemiology Services, Public Health England, Victoria, London, UK. ; Department of Toxicology, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. ; Department of Psychology, University College London, UK. ; Department of Emergency Medicine, University College Hospital, London, UK. ; North East & North Central London Health Protection Team, Public Health England, London, UK. ; Emergency Response Department, Public Health England, UK. ; Department of Epidemiology, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK; London School of Hygiene and Tropical Medicine, London, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 75 EP - 82 VL - 72 KW - Index Medicus KW - Health register KW - Major incident KW - Epidemiological follow-up KW - Epidemiologic Studies KW - Humans KW - Disaster Planning -- standards KW - Disaster Planning -- legislation & jurisprudence KW - England KW - Civil Defense -- methods KW - Health Services Needs and Demand -- legislation & jurisprudence KW - Civil Defense -- legislation & jurisprudence KW - Civil Defense -- standards KW - Health Services Needs and Demand -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Preparedness+for+a+major+incident%3A+creation+of+an+epidemiology+protocol+for+a+health+protection+register+in+England.&rft.au=Close%2C+R+M%3BMaguire%2C+H%3BEtherington%2C+G%3BBrewin%2C+C+R%3BFong%2C+K%3BSaliba%2C+V%3BBarker%2C+R+M%3BLeonardi%2C+G+S&rft.aulast=Close&rft.aufirst=R&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.05.003 ER - TY - JOUR T1 - Establishing the importance of human health risk assessment for metals and metalloids in urban environments. AN - 1552807645; 24791693 AB - Rapid development, industrialisation, and urbanisation have resulted in serious contamination of soil by metals and metalloids from anthropogenic sources in many areas of the world, either directly or indirectly. Exponential urban and economic development has resulted in human populations settling in urban areas and as a result being exposed to these pollutants. Depending on the nature of the contaminant, contaminated urban soils can have a deleterious effect on the health of exposed populations and may require decontamination, recovery, remediation and restoration. Therefore, human health risk assessments in urban environments are very important. In the case of Spain, there are few studies regarding risk assessment of trace elements in urban soils, and those that exist have been derived mainly from areas potentially exposed to industrial contamination or in the vicinity of point pollution. The present study analysed Al, As, Be, Cd, Cr, Cu, Hg, Mn, Ni, Pb, Sn, Ti, Tl, V and Zn soil concentrations in and around the city of Alcalá de Henares (35 km NE of Madrid). Soil samples were collected in public parks and recreation areas within the city and in an industrial area on the periphery of the city. From these results, an assessment of the health risk for the population was performed following the methodology described by the US EPA (1989). In general, it was observed that there could be a potential increased risk of developing cancer over a lifetime from exposure to arsenic (As) through ingestion of the soils studied (oral intake), as well as an increased risk of cancer due to inhalation of chromium (Cr) present in re-suspended soils from the industrial area. Our group has previously reported (Granero and Domingo, 2002; Peña-Fernández et al., 2003) that there was an increased risk of developing cancer following exposure to As in the same soils in a previous study. Therefore, it is necessary to reduce the levels of contaminants in these soils, especially As and Cr as these have been found to exceed safe levels for human health. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Peña-Fernández, A AU - González-Muñoz, M J AU - Lobo-Bedmar, M C AD - Universidad de Alcalá, Unidad Docente de Toxicología, Departamento de Ciencias Biomédicas, Crta. Madrid-Barcelona km. 33.6, 28871 Alcalá de Henares, Madrid, Spain. Electronic address: Antonio.Pena-Fernandez@phe.gov.uk. ; Universidad de Alcalá, Unidad Docente de Toxicología, Departamento de Ciencias Biomédicas, Crta. Madrid-Barcelona km. 33.6, 28871 Alcalá de Henares, Madrid, Spain. ; Instituto Madrileño de Investigación y Desarrollo Rural Agrario y Alimentario (IMIDRA), Finca el Encín, Crta. Madrid-Barcelona km. 38.2, 28800 Alcalá de Henares, Madrid, Spain. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 176 EP - 185 VL - 72 KW - Metalloids KW - 0 KW - Metals KW - Soil Pollutants KW - Chromium KW - 0R0008Q3JB KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Human risk assessment KW - Urban soils KW - Contaminated soil KW - Metals and metalloids KW - Cities KW - Arsenic -- analysis KW - Chromium -- analysis KW - Humans KW - Principal Component Analysis KW - Environmental Exposure -- prevention & control KW - Risk Assessment KW - Environmental Monitoring KW - Metalloids -- analysis KW - Soil Pollutants -- chemistry KW - Metals -- analysis KW - Soil Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Establishing+the+importance+of+human+health+risk+assessment+for+metals+and+metalloids+in+urban+environments.&rft.au=Pe%C3%B1a-Fern%C3%A1ndez%2C+A%3BGonz%C3%A1lez-Mu%C3%B1oz%2C+M+J%3BLobo-Bedmar%2C+M+C&rft.aulast=Pe%C3%B1a-Fern%C3%A1ndez&rft.aufirst=A&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.04.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.04.007 ER - TY - JOUR T1 - Factors influencing recovery and restoration following a chemical incident. AN - 1552807582; 24874002 AB - Chemicals are an important part of our society. A wide range of chemicals are discharged into the environment every day from residential, commercial and industrial sources. Many of these discharges do not pose a threat to public health or the environment. However, global events have shown that chemical incidents or accidents can have severe consequences on human health, the environment and society. It is important that appropriate tools and technical guidance are available to ensure that a robust and efficient approach to developing a remediation strategy is adopted. The purpose of remediation is to protect human health from future exposure and to return the affected area back to normal as soon as possible. There are a range of recovery options (techniques or methods for remediation) that are applicable to a broad range of chemicals and incidents. Recovery options should be evaluated according to their appropriateness and efficacy for removing contaminants from the environment; however economic drivers and social and political considerations often influence decision makers on which remedial actions are implemented during the recovery phase of a chemical incident. To date, there is limited information in the literature on remediation strategies and recovery options that have been implemented following a chemical incident, or how successful they have been. Additional factors that can affect the approach taken for recovery are not well assessed or understood by decision makers involved in the remediation and restoration of the environment following a chemical incident. The identification of this gap has led to the development of the UK Recovery Handbook for Chemical Incidents to provide a framework for choosing an effective recovery strategy. A compendium of practical evidence-based recovery options (techniques or methods for remediation) for inhabited areas, food production systems and water environments has also been developed and is included in the chemical handbook. This paper presents the key factors that should be considered when developing a recovery strategy with respect to how these may impact on its effectiveness. The paper also highlights the importance of these factors through an evaluation of recovery strategies implemented following real chemical incidents that have been reported in the literature. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Peña-Fernández, A AU - Wyke, S AU - Brooke, N AU - Duarte-Davidson, R AD - Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. Electronic address: Antonio.Pena-Fernandez@phe.gov.uk. ; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 98 EP - 108 VL - 72 KW - Index Medicus KW - factors KW - effectiveness of remediation KW - chemical incident KW - Recovery and restoration KW - Environmental Pollution -- prevention & control KW - Environmental Monitoring KW - Humans KW - Groundwater -- analysis KW - Decontamination KW - Environmental Pollution -- analysis KW - Risk Assessment KW - Disaster Planning -- methods KW - Chemical Hazard Release -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Factors+influencing+recovery+and+restoration+following+a+chemical+incident.&rft.au=Pe%C3%B1a-Fern%C3%A1ndez%2C+A%3BWyke%2C+S%3BBrooke%2C+N%3BDuarte-Davidson%2C+R&rft.aulast=Pe%C3%B1a-Fern%C3%A1ndez&rft.aufirst=A&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.05.001 ER - TY - JOUR T1 - Monitoring lead in hair of children and adolescents of Alcalá de Henares, Spain. A study by gender and residential areas. AN - 1552806727; 24679380 AB - In recent years there has been an increased interest from the European Union (EU) in the development of large Human Bio-monitoring (HBM) studies across Europe, especially biomonitoring toxic metals. In Spain, most studies using hair as a biomarker have been conducted to determine occupational or industrial exposures, and have involved adult populations. Few studies have involved adolescents and children, despite these groups being sensitive to environmental contamination and pollutants. Therefore, the objective of the present study was to determine the degree of lead exposure in children and adolescents residing in Alcalá de Henares, Spain. Lead poisoning is the number one toxicological threat in the environment. So, lead (Pb) was selected as it is a persistent environmental contaminant, is measureable and is also a neurotoxin that can affect brain development. The city of Alcalá de Henares was divided into four zones to determine the influence of residence area on Pb levels. A range of other variables including age and gender were also considered within the study. The study comprised 115 children (6-9 years old) and 96 adolescents (13-16 years old). There was a significant difference between the levels of Pb in the hair of adolescents, for different gender and area of residence (p<0.001 and p<0.01 respectively). There was no significant difference in the Pb levels in hair of children, for different gender or area of the city. The levels of Pb were significantly (p<0.001) elevated in children compared to adolescents (1.48 vs. 0.70 μg/g), and there was a significant difference in Pb levels in male and female adolescent hair (0.53 vs. 0.77 μg/g) (p<0.001). The association observed between areas of residence and the Pb level in hair of the adolescent group could be mainly attributed to dietary habits and/or socioeconomic status. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Peña-Fernández, A AU - Lobo-Bedmar, M C AU - González-Muñoz, M J AD - Universidad de Alcalá, Unidad de Toxicología, Departamento de Ciencias Biomédicas, Crta. Madrid-Barcelona Km, 33.6, 28871 Alcalá de Henares, Madrid, Spain. Electronic address: Antonio.Pena-Fernandez@phe.gov.uk. ; Instituto Madrileño de Investigación y Desarrollo Rural Agrario y Alimentario (IMIDRA), Finca el Encín, Crta. Madrid-Barcelona Km, 38.2, 28800 Alcalá de Henares, Madrid, Spain. ; Universidad de Alcalá, Unidad de Toxicología, Departamento de Ciencias Biomédicas, Crta. Madrid-Barcelona Km, 33.6, 28871 Alcalá de Henares, Madrid, Spain. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 170 EP - 175 VL - 72 KW - Environmental Pollutants KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Age and gender KW - Monitoring KW - Children and adolescents KW - Human hair KW - Age Factors KW - Sex Factors KW - Spain KW - Humans KW - Child KW - Residence Characteristics KW - Adolescent KW - Male KW - Female KW - Environmental Monitoring KW - Hair -- chemistry KW - Environmental Pollutants -- analysis KW - Lead -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552806727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Monitoring+lead+in+hair+of+children+and+adolescents+of+Alcal%C3%A1+de+Henares%2C+Spain.+A+study+by+gender+and+residential+areas.&rft.au=Pe%C3%B1a-Fern%C3%A1ndez%2C+A%3BLobo-Bedmar%2C+M+C%3BGonz%C3%A1lez-Mu%C3%B1oz%2C+M+J&rft.aulast=Pe%C3%B1a-Fern%C3%A1ndez&rft.aufirst=A&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.03.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.03.010 ER - TY - JOUR T1 - Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol. AN - 1561969754; 25069035 AB - Recently we found that mice bearing subcutaneous non-metastatic tumors exhibited elevated levels of two types of complex DNA damage, i.e., double-strand breaks and oxidatively-induced clustered DNA lesions in various tissues throughout the body, both adjacent to and distant from the tumor site. This DNA damage was dependent on CCL2, a cytokine involved in the recruitment and activation of macrophages, suggesting that this systemic DNA damage was mediated via tumor-induced chronic inflammatory responses involving cytokines, activation of macrophages, and consequent free radical production. If free radicals are involved, then a diet containing an antioxidant may decrease the distant DNA damage. Here we repeated our standard protocol in cohorts of two syngeneic tumor-bearing C57BL/6NCr mice that were on a Tempol-supplemented diet. We show that double-strand break and oxidatively-induced clustered DNA lesion levels were considerably decreased, about two- to three fold, in the majority of tissues studied from the tumor-bearing mice fed the antioxidant Tempol compared to the control tumor-bearing mice. Similar results were also observed in nude mice suggesting that the Tempol effects are independent of functioning adaptive immunity. This is the first in vivo study demonstrating the effect of a dietary antioxidant on abscopal DNA damage in tissues distant from a localized source of genotoxic stress. These findings may be important for understanding the mechanisms of genomic instability and carcinogenesis caused by chronic stress-induced systemic DNA damage and for developing preventative strategies. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Cancer letters AU - Georgakilas, Alexandros G AU - Redon, Christophe E AU - Ferguson, Nicholas F AU - Kryston, Thomas B AU - Parekh, Palak AU - Dickey, Jennifer S AU - Nakamura, Asako J AU - Mitchell, James B AU - Bonner, William M AU - Martin, Olga A AD - Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA; Department of Physics, National Technical University of Athens, Zografou Campus, Athens GR-15773, Greece. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. ; Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Office of In Vitro Diagnostics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Department of Biological Sciences, Faculty of Science, Ibaraki University, Ibaraki 310-8512, Japan. ; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Laboratory of Molecular Radiation Biology, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic. 3002, Australia. Electronic address: olga.martin@petermac.org. Y1 - 2014/10/28/ PY - 2014 DA - 2014 Oct 28 SP - 248 EP - 257 VL - 353 IS - 2 KW - Antioxidants KW - 0 KW - Cyclic N-Oxides KW - Reactive Oxygen Species KW - Spin Labels KW - tempol KW - U78ZX2F65X KW - Index Medicus KW - DNA damage KW - Tumor-bearing mice KW - Non-targeted effects KW - Tempol KW - Neoplasm Transplantation KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Gastrointestinal Tract -- pathology KW - Gastrointestinal Tract -- drug effects KW - Mice, Inbred C57BL KW - Mice, Nude KW - Mice KW - Female KW - Antioxidants -- pharmacology KW - Cyclic N-Oxides -- pharmacology KW - DNA Breaks, Double-Stranded KW - Melanoma, Experimental -- genetics KW - Carcinoma, Lewis Lung -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561969754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Systemic+DNA+damage+accumulation+under+in+vivo+tumor+growth+can+be+inhibited+by+the+antioxidant+Tempol.&rft.au=Georgakilas%2C+Alexandros+G%3BRedon%2C+Christophe+E%3BFerguson%2C+Nicholas+F%3BKryston%2C+Thomas+B%3BParekh%2C+Palak%3BDickey%2C+Jennifer+S%3BNakamura%2C+Asako+J%3BMitchell%2C+James+B%3BBonner%2C+William+M%3BMartin%2C+Olga+A&rft.aulast=Georgakilas&rft.aufirst=Alexandros&rft.date=2014-10-28&rft.volume=353&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=1872-7980&rft_id=info:doi/10.1016%2Fj.canlet.2014.07.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-11 N1 - Date created - 2014-09-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Free Radic Biol Med. 2003 Jan 1;34(1):93-102 [12498984] Neurosci Res. 2003 Jan;45(1):1-8 [12507718] Nat Rev Cancer. 2003 Apr;3(4):276-85 [12671666] Am J Physiol Cell Physiol. 2003 Aug;285(2):C353-69 [12686516] Cancer Biol Ther. 2003 May-Jun;2(3):233-5 [12878854] Mutat Res. 2003 Oct 29;531(1-2):93-107 [14637248] Br J Pharmacol. 2004 Jan;141(1):105-13 [14656807] Hypertension. 2004 Feb;43(2):329-34 [14707156] Nat Cell Biol. 2004 Feb;6(2):168-70 [14755273] Mutagenesis. 2004 May;19(3):169-85 [15123782] Hepatology. 2004 Jun;39(6):1663-72 [15185308] Clin Cancer Res. 2004 Oct 1;10(19):6411-7 [15475427] Cancer Res. 1991 Feb 1;51(3):794-8 [1846317] Int J Radiat Oncol Biol Phys. 1992;22(4):803-6 [1544853] FEBS Lett. 1995 Jan 16;358(1):1-3 [7821417] Free Radic Biol Med. 1997;23(6):879-84 [9378367] Radiat Res. 2005 Mar;163(3):316-23 [15733038] Hum Mol Genet. 2005 Jun 15;14(12):1699-708 [15888486] Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14641-6 [16203985] Oncogene. 2005 Nov 10;24(49):7257-65 [16170376] Mutat Res. 2006 May 11;597(1-2):113-8 [16413041] Mutat Res. 2010 Feb;696(1):16-20 [20018253] Free Radic Biol Med. 2010 Mar 1;48(5):704-12 [20035861] Nat Rev Mol Cell Biol. 2010 Mar;11(3):220-8 [20177397] Oncologist. 2010;15(4):360-71 [20413641] Cancer Metastasis Rev. 2010 Jun;29(2):351-78 [20386957] J Biomed Opt. 2010 Mar-Apr;15(2):027006 [20459280] Mutat Res. 2010 Apr-Jun;704(1-3):152-9 [20060490] Cell Cycle. 2010 Aug 15;9(16):3256-76 [20814239] Chem Biol Interact. 2010 Nov 5;188(2):350-8 [20371364] Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17992-7 [20855610] Free Radic Biol Med. 2011 Feb 1;50(3):459-68 [21130158] Acta Cytol. 2010 Nov-Dec;54(6):1127-9 [21428160] Cancer Res. 2011 May 15;71(10):3437-41 [21558390] Mutat Res. 2011 Jun 3;711(1-2):142-9 [21185842] Mutat Res. 2011 Jun 3;711(1-2):193-201 [21216256] Free Radic Biol Med. 2011 Aug 1;51(3):780-90 [21664459] Cancer Immunol Immunother. 2011 Aug;60(8):1161-71 [21626032] Cell Cycle. 2011 Aug 1;10(15):2504-20 [21778829] J Thorac Cardiovasc Surg. 2011 Nov;142(5):1254-62 [21843894] Mutagenesis. 2012 Jan;27(1):77-86 [21980144] Cancer Res. 2012 Jun 1;72(11):2768-79 [22472119] Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):1284-90 [22197226] Curr Mol Med. 2012 Jul 1;12(6):672-80 [22292435] Cancer Res. 2012 Sep 15;72(18):4846-55 [22805306] Cancer Lett. 2012 Dec 31;327(1-2):123-33 [22198208] Nucleic Acids Res. 2012 Nov 1;40(20):10274-86 [22941641] Radiat Res. 2013 Jul;180(1):100-9 [23682596] PLoS One. 2013;8(8):e70575 [23940596] Cancer Lett. 2015 Jan 1;356(1):72-81 [24041866] Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):103-8 [10618378] J Neurosurg. 2000 Apr;92(4):646-51 [10761655] Cancer J Sci Am. 1996 Sep-Oct;2(5):273-8 [9166544] J Leukoc Biol. 2006 Oct;80(4):705-13 [16864600] Eur J Pharmacol. 2006 Nov 7;549(1-3):50-7 [16989807] J Nutr. 2007 Jan;137(1 Suppl):229S-232S [17182831] Radiat Res. 2007 Feb;167(2):207-16 [17390728] Free Radic Biol Med. 2007 Jun 1;42(11):1632-50 [17462532] Cancer Res. 2007 May 1;67(9):4295-302 [17483342] Cell Cycle. 2007 Sep 15;6(18):2210-2 [17881892] Radiat Res. 2007 Nov;168(5):527-34 [17973547] Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2726-37 [17675574] Mol Biosyst. 2008 Jan;4(1):30-5 [18075671] Oncogene. 2008 Jan 17;27(4):434-40 [17621264] Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):554-62 [18207032] Aging Cell. 2008 Jan;7(1):89-100 [18005250] Nat Rev Cancer. 2008 Mar;8(3):180-92 [18273037] Nat Genet. 2008 Mar;40(3):356-61 [18246068] Cancer Res. 2008 Mar 1;68(5):1601-8 [18316625] J Radiat Res. 2008 May;49(3):203-10 [18413977] Cell Cycle. 2008 May 1;7(9):1238-45 [18418050] Science. 2008 Jun 13;320(5882):1507-10 [18483401] Nature. 2008 Jul 24;454(7203):436-44 [18650914] Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12445-50 [18711141] Cancer Res. 2008 Sep 1;68(17):7059-65 [18757420] Nat Rev Cancer. 2008 Dec;8(12):957-67 [19005492] PLoS Biol. 2008 Dec 2;6(12):2853-68 [19053174] Mutat Res. 2009 Mar 31;674(1-2):131-6 [18948225] Blood. 2000 Jul 1;96(1):307-13 [10891466] Oncogene. 2006 Jul 20;25(31):4267-75 [16532033] Nat Rev Cancer. 2009 May;9(5):351-60 [19377507] NMR Biomed. 2009 Jun;22(5):532-7 [19156686] Carcinogenesis. 2009 Oct;30(10):1686-95 [19651821] Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):1247-53 [19857788] Chromosoma. 2009 Dec;118(6):683-92 [19707781] Am J Physiol Renal Physiol. 2010 Jan;298(1):F86-94 [19906952] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.canlet.2014.07.030 ER - TY - JOUR T1 - Technology-Based Interventions in Social Work Practice: A Systematic Review of Mental Health Interventions AN - 1680149817; 201503539 AB - Despite concerns around the use of technology-based interventions, they are increasingly being employed by social workers as a direct practice methodology to address the mental health needs of vulnerable clients. Researchers have highlighted the importance of using innovative technologies within social work practice, yet little has been done to summarize the evidence and collectively assess findings. In this systematic review, we describe accounts of technology-based mental health interventions delivered by social workers over the past 10 years. Results highlight the impacts of these tools and summarize advantages and disadvantages to utilizing technologies as a method for delivering or facilitating interventions. Adapted from the source document. JF - Social Work in Health Care AU - Ramsey, Alex T AU - Montgomery, Katherine AD - Center for Mental Health Services Research, Brown School of Social Work, Washington University in St. Louis, St. Louis, Missouri, USA Y1 - 2014/10/21/ PY - 2014 DA - 2014 Oct 21 SP - 883 EP - 899 PB - Taylor & Francis, Philadelphia PA VL - 53 IS - 9 SN - 0098-1389, 0098-1389 KW - Social Workers KW - Intervention KW - Mental Health KW - Vulnerability KW - Social Work KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680149817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Technology-Based+Interventions+in+Social+Work+Practice%3A+A+Systematic+Review+of+Mental+Health+Interventions&rft.au=Ramsey%2C+Alex+T%3BMontgomery%2C+Katherine&rft.aulast=Ramsey&rft.aufirst=Alex&rft.date=2014-10-21&rft.volume=53&rft.issue=9&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/10.1080%2F00981389.2014.925531 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SWHCDO N1 - SubjectsTermNotLitGenreText - Intervention; Mental Health; Social Work; Social Workers; Vulnerability DO - http://dx.doi.org/10.1080/00981389.2014.925531 ER - TY - JOUR T1 - A case-control study of occupational exposure to metalworking fluids and bladder cancer risk among men AN - 1808660494; PQ0003443722 AB - ObjectivesMetalworking has been associated with an excess risk of bladder cancer in over 20 studies. Metalworking fluids (MWFs) are suspected as the responsible exposure, but epidemiological data are limited. We investigated this association among men in the New England Bladder Cancer Study using state-of-the-art, quantitative exposure assessment methods.MethodsCases (n=895) and population controls (n=1031) provided occupational histories during personal interviews. For selected jobs, exposure-oriented modules were administered to collect information on use of three MWF types: (1) straight (mineral oil, additives), (2) soluble (mineral oil, water, additives) and (3) synthetic (water, organics, additives) or semisynthetic (hybrid of soluble and synthetic). We computed ORs and 95% CIs relating bladder cancer risk to a variety of exposure metrics, adjusting for smoking and other factors. Non-metalworkers who had held jobs with possible exposure to mineral oil were analysed separately.ResultsBladder cancer risk was elevated among men who reported using straight MWFs (OR=1.7, 95% CI 1.1 to 2.8); risk increased monotonically with increasing cumulative exposure (p=0.041). Use of soluble MWFs was associated with a 50% increased risk (95% CI 0.96 to 2.5). ORs were non-significantly elevated for synthetic/semisynthetic MWFs based on a small number of exposed men. Non-metalworkers holding jobs with possible exposure to mineral oil had a 40% increased risk (95% CI 1.1 to 1.8).ConclusionsExposure to straight MWFs was associated with a significantly increased bladder cancer risk, as was employment in non-metalworking jobs with possible exposure to mineral oil. These findings strengthen prior evidence for mineral oil as a bladder carcinogen. JF - Occupational and Environmental Medicine AU - Colt, Joanne S AU - Friesen, Melissa C AU - Stewart, Patricia A AU - Donguk, Park AU - Johnson, Alison AU - Schwenn, Molly AU - Karagas, Margaret R AU - Armenti, Karla AU - Waddell, Richard AU - Verrill, Castine AU - Ward, Mary H AU - Beane Freeman, Laura E AU - Moore, Lee E AU - Koutros, Stella AU - Baris, Dalsu AU - Silverman, Debra T AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2014/10/20/ PY - 2014 DA - 2014 Oct 20 SP - 667 EP - 674 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 71 IS - 10 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Historical account KW - mineral oil KW - Data processing KW - Urinary bladder KW - Males KW - Employment KW - Carcinogens KW - Metal-working fluids KW - Cancer KW - Oil KW - Health risks KW - Smoking KW - Population control KW - USA, New England KW - Risk factors KW - Hybrids KW - Additives KW - Minerals KW - Occupational exposure KW - X 24380:Social Poisons & Drug Abuse KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808660494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=A+case-control+study+of+occupational+exposure+to+metalworking+fluids+and+bladder+cancer+risk+among+men&rft.au=Colt%2C+Joanne+S%3BFriesen%2C+Melissa+C%3BStewart%2C+Patricia+A%3BDonguk%2C+Park%3BJohnson%2C+Alison%3BSchwenn%2C+Molly%3BKaragas%2C+Margaret+R%3BArmenti%2C+Karla%3BWaddell%2C+Richard%3BVerrill%2C+Castine%3BWard%2C+Mary+H%3BBeane+Freeman%2C+Laura+E%3BMoore%2C+Lee+E%3BKoutros%2C+Stella%3BBaris%2C+Dalsu%3BSilverman%2C+Debra+T&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2014-10-20&rft.volume=71&rft.issue=10&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2013-102056 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Smoking; mineral oil; Data processing; Urinary bladder; Hybrids; Carcinogens; Occupational exposure; Cancer; Risk assessment; Historical account; Males; Employment; Metal-working fluids; Oil; Health risks; Population control; Risk factors; Minerals; Additives; USA, New England DO - http://dx.doi.org/10.1136/oemed-2013-102056 ER - TY - JOUR T1 - Reaction of dehydropyrrolizidine alkaloids with valine and hemoglobin. AN - 1614700268; 25211425 AB - Pyrrolizidine alkaloid-containing plants are probably the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids exert toxicity through metabolism to dehydropyrrolizidine alkaloids that bind to cellular protein and DNA, leading to hepatotoxicity, genotoxicity, and tumorigenicity. To date, it is not clear how dehydropyrrolizidine alkaloids bind to cellular constituents, including amino acids and proteins, resulting in toxicity. Metabolism of carcinogenic monocrotaline, riddelliine, and heliotrine produces dehydromonocrotaline, dehyroriddelliine, and dehydroheliotrine, respectively, as primary reactive metabolites. In this study, we report that reaction of dehydromonocrotaline with valine generated four highly unstable 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived valine (DHP-valine) adducts. For structural elucidation, DHP-valine adducts were derivatized with phenyl isothiocyanate (PITC) to DHP-valine-PITC products. After HPLC separation, their structures were characterized by mass spectrometry, UV-visible spectrophotometry, (1)H NMR, and (1)H-(1)H COSY NMR spectral analysis. Two DHP-valine-PITC adducts, designated as DHP-valine-PITC-1 and DHP-valine-PITC-3, had the amino group of valine linked to the C7 position of the necine base, and the other two DHP-valine-PITC products, DHP-valine-PITC-2 and DHP-valine-PITC-4, linked to the C9 position of the necine base. DHP-valine-PITC-1 was interconvertible with DHP-valine-PITC-3, and DHP-valine-PITC-2 was interconvertible with DHP-valine-PITC-4. Reaction of dehydroriddelliine and dehydroheliotrine with valine provided similar results. However, reaction of valine and dehydroretronecine (DHR) under similar experimental conditions did not produce DHP-valine adducts. Reaction of dehydromonocrotaline with rat hemoglobin followed by derivatization with PITC also generated the same four DHP-valine-PITC adducts. This represents the first full structural elucidation of protein conjugated pyrrolic adducts formed from reaction of dehydropyrrolizidine alkaloids with an amino acid (valine). In addition, it was found that DHP-valine-2 and DHP-valine-4, with the valine amino group linked at the C7 position of the necine base, can lose the valine moiety to form DHP. JF - Chemical research in toxicology AU - Zhao, Yuewei AU - Wang, Shuguang AU - Xia, Qingsu AU - Gamboa da Costa, Gonçalo AU - Doerge, Daniel R AU - Cai, Lining AU - Fu, Peter P AD - National Center for Toxicological Research , Jefferson, Arkansas 72079, United States. Y1 - 2014/10/20/ PY - 2014 DA - 2014 Oct 20 SP - 1720 EP - 1731 VL - 27 IS - 10 KW - Alkaloids KW - 0 KW - Hemoglobins KW - Isothiocyanates KW - Pyrrolizidine Alkaloids KW - phenylisothiocyanate KW - 0D58F84LSU KW - riddelliine KW - 23246-96-0 KW - Monocrotaline KW - 73077K8HYV KW - Valine KW - HG18B9YRS7 KW - dehydroretronecine KW - QG6MWR17OH KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Monocrotaline -- analogs & derivatives KW - Tandem Mass Spectrometry KW - Monocrotaline -- chemistry KW - Isothiocyanates -- chemistry KW - Female KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Alkaloids -- chemistry KW - Hemoglobins -- chemistry KW - Valine -- chemistry KW - Pyrrolizidine Alkaloids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1614700268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Reaction+of+dehydropyrrolizidine+alkaloids+with+valine+and+hemoglobin.&rft.au=Zhao%2C+Yuewei%3BWang%2C+Shuguang%3BXia%2C+Qingsu%3BGamboa+da+Costa%2C+Gon%C3%A7alo%3BDoerge%2C+Daniel+R%3BCai%2C+Lining%3BFu%2C+Peter+P&rft.aulast=Zhao&rft.aufirst=Yuewei&rft.date=2014-10-20&rft.volume=27&rft.issue=10&rft.spage=1720&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx5002139 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-23 N1 - Date created - 2014-10-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/tx5002139 ER - TY - JOUR T1 - Stat3 signaling regulates embryonic stem cell fate in a dose-dependent manner AN - 1808683230; PQ0003451472 AB - Stat3 is essential for mouse embryonic stem cell (mESC) self-renewal mediated by LIF/gp130 receptor signaling. Current understanding of Stat3-mediated ESC self-renewal mechanisms is very limited, and has heretofore been dominated by the view that Stat3 signaling functions in a binary "on/off" manner. Here, in contrast to this binary viewpoint, we demonstrate a contextual, rheostat-like mechanism for Stat3's function in mESCs. Activation and expression levels determine whether Stat3 functions in a self-renewal or a differentiation role in mESCs. We also show that Stat3 induces rapid differentiation of mESCs toward the trophectoderm (TE) lineage when its activation level exceeds certain thresholds. Stat3 induces this differentiation phenotype via induction of Tfap2c and its downstream target Cdx2. Our findings provide a novel concept in the realm of Stat3, self-renewal signaling, and pluripotent stem cell biology. Ultimately, this finding may facilitate the development of conditions for the establishment of authentic non-rodent ESCs. JF - Biology Open AU - Tai, Chih-I AU - Schulze, Eric N AU - Ying, Qi-Long AD - Present address: Animal Biotechnology Interdisciplinary Group, Center for Veterinary Medicine, United States Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA Y1 - 2014/10/15/ PY - 2014 DA - 2014 Oct 15 SP - 958 EP - 965 PB - The Company of Biologists Ltd., 140 Cowley Rd Cambridge, CB4 0DL United Kingdom VL - 3 IS - 10 SN - 2046-6390, 2046-6390 KW - Biotechnology and Bioengineering Abstracts KW - Stat3 KW - Embryonic stem cell KW - Pluripotency KW - Differentiation KW - Stem cells KW - Glycoprotein gp130 KW - CDX2 protein KW - Embryo cells KW - Stat3 protein KW - trophectoderm KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808683230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+Open&rft.atitle=Stat3+signaling+regulates+embryonic+stem+cell+fate+in+a+dose-dependent+manner&rft.au=Tai%2C+Chih-I%3BSchulze%2C+Eric+N%3BYing%2C+Qi-Long&rft.aulast=Tai&rft.aufirst=Chih-I&rft.date=2014-10-15&rft.volume=3&rft.issue=10&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Biology+Open&rft.issn=20466390&rft_id=info:doi/10.1242%2Fbio.20149514 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Differentiation; Glycoprotein gp130; Stem cells; CDX2 protein; Embryo cells; Stat3 protein; trophectoderm DO - http://dx.doi.org/10.1242/bio.20149514 ER - TY - JOUR T1 - Is organic farming safer to farmers' health? A comparison between organic and traditional farming. AN - 1563986646; 24576785 AB - Exposure to pesticides is a major public health concern, because of the widespread distribution of these compounds and their possible long term effects. Recently, organic farming has been introduced as a consumer and environmental friendly agricultural system, although little is known about the effects on workers' health. The aim of this work was to evaluate genetic damage and immunological alterations in workers of both traditional and organic farming. Eighty-five farmers exposed to several pesticides, thirty-six organic farmers and sixty-one controls took part in the study. Biomarkers of exposure (pyrethroids, organophosphates, carbamates, and thioethers in urine and butyrylcholinesterase activity in plasma), early effect (micronuclei in lymphocytes and reticulocytes, T-cell receptor mutation assay, chromosomal aberrations, comet assay and lymphocytes subpopulations) and susceptibility (genetic polymorphisms related to metabolism - EPHX1, GSTM1, GSTT1 and GSTP1 - and DNA repair-XRCC1 and XRCC2) were evaluated. When compared to controls and organic farmers, pesticide farmers presented a significant increase of micronuclei in lymphocytes (frequency ratio, FR=2.80) and reticulocytes (FR=1.89), chromosomal aberrations (FR=2.19), DNA damage assessed by comet assay (mean ratio, MR=1.71), and a significant decrease in the proportion of B lymphocytes (MR=0.88). Results were not consistent for organic farmers when compared to controls, with a 48% increase of micronuclei in lumphocytes frequency (p=0.016) contrasted by the significant decreases of TCR-Mf (p=0.001) and %T (p=0.001). Our data confirm the increased presence of DNA damage in farmers exposed to pesticides, and show as exposure conditions may influence observed effects. These results must be interpreted with caution due to the small size of the sample and the unbalanced distribution of individuals in the three study groups. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology letters AU - Costa, Carla AU - García-Lestón, Julia AU - Costa, Solange AU - Coelho, Patrícia AU - Silva, Susana AU - Pingarilho, Marta AU - Valdiglesias, Vanessa AU - Mattei, Francesca AU - Dall'Armi, Valentina AU - Bonassi, Stefano AU - Laffon, Blanca AU - Snawder, John AU - Teixeira, João Paulo AD - Department of Environmental Health, Portuguese National Institute of Health, Rua Alexandre Herculano, 321, 4000-055 Porto, Portugal. Electronic address: cstcosta@gmail.com. ; Toxicology Unit, Department of Psychobiology, University of A Coruña, Edificio de Servicios Centrales de Investigación, Campus Elviña s/n, 15071 A Coruña, Spain. ; Department of Environmental Health, Portuguese National Institute of Health, Rua Alexandre Herculano, 321, 4000-055 Porto, Portugal. ; Department of Genetics, Faculty of Medical Sciences UNL, Rua da Junqueira 100, 1349-008 Lisbon, Portugal. ; Toxicology Unit, Department of Psychobiology, University of A Coruña, Edificio de Servicios Centrales de Investigación, Campus Elviña s/n, 15071 A Coruña, Spain; Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Via di Val Cannuta, 247, 00166 Rome, Italy. ; Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Via di Val Cannuta, 247, 00166 Rome, Italy. ; Biomonitoring and Health Assessment Branch of the Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, United States of America. Y1 - 2014/10/15/ PY - 2014 DA - 2014 Oct 15 SP - 166 EP - 176 VL - 230 IS - 2 KW - Biomarkers KW - 0 KW - Pesticides KW - glutathione S-transferase T1 KW - EC 2.5.1.- KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Immunotoxicity KW - Genotoxicity KW - Organic farming KW - DNA Damage KW - Humans KW - Lymphocyte Subsets -- drug effects KW - Adult KW - Aged KW - Middle Aged KW - Glutathione Transferase -- genetics KW - Adolescent KW - Male KW - Female KW - Organic Agriculture KW - Occupational Exposure -- adverse effects KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1563986646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Is+organic+farming+safer+to+farmers%27+health%3F+A+comparison+between+organic+and+traditional+farming.&rft.au=Costa%2C+Carla%3BGarc%C3%ADa-Lest%C3%B3n%2C+Julia%3BCosta%2C+Solange%3BCoelho%2C+Patr%C3%ADcia%3BSilva%2C+Susana%3BPingarilho%2C+Marta%3BValdiglesias%2C+Vanessa%3BMattei%2C+Francesca%3BDall%27Armi%2C+Valentina%3BBonassi%2C+Stefano%3BLaffon%2C+Blanca%3BSnawder%2C+John%3BTeixeira%2C+Jo%C3%A3o+Paulo&rft.aulast=Costa&rft.aufirst=Carla&rft.date=2014-10-15&rft.volume=230&rft.issue=2&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2014.02.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-25 N1 - Date created - 2014-09-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 1998 Nov;7(11):1013-8 [9829710] Mutat Res. 1999 May 17;441(2):225-37 [10333536] Cancer Res. 1999 Jun 1;59(11):2557-61 [10363972] Age Ageing. 1999 Jul;28(4):393-7 [10459794] Arch Environ Contam Toxicol. 1999 Oct;37(3):415-23 [10473800] Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):258-70 [15688363] Clin Immunol. 2005 Aug;116(2):192-7 [15993366] Hum Exp Toxicol. 2005 Sep;24(9):439-45 [16235732] Mutat Res. 2006 Mar;612(2):84-104 [16314140] Mutagenesis. 2006 Mar;21(2):143-8 [16540494] Mutagenesis. 2006 Mar;21(2):93-103 [16567350] Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):659-66 [16614106] Toxicology. 2006 Jun 15;223(3):219-26 [16713056] Environ Toxicol. 2006 Aug;21(4):355-9 [16841319] Cancer Detect Prev. 2007;31(4):303-9 [17935911] Mutat Res. 2008 Jul 31;654(2):168-75 [18603015] Toxicology. 2008 Oct 30;252(1-3):40-8 [18721846] Hum Exp Toxicol. 2008 Sep;27(9):671-80 [19042949] Cell Biol Toxicol. 2009 Feb;25(1):53-64 [18040874] Environ Int. 2009 Feb;35(2):273-8 [18678410] Trends Immunol. 2009 Jul;30(7):325-33 [19541535] J Toxicol Environ Health A. 2009;72(15-16):986-97 [19672767] Transpl Int. 2009 Nov;22(11):1041-50 [19624493] Thyroid. 2009 Oct;19(10):1067-75 [19772428] Mutat Res. 2010 Jul-Sep;705(1):11-9 [19932192] Mutat Res. 2011 Mar 18;721(1):81-8 [21241821] J Toxicol Environ Health A. 2011;74(15-16):960-70 [21707421] Mutat Res. 2011 Oct 9;725(1-2):36-42 [21736951] J Toxicol Environ Health A. 2012;75(13-15):807-18 [22788368] Environ Mol Mutagen. 2003;41(2):104-10 [12605379] Arch Environ Health. 1999 Nov-Dec;54(6):425-9 [10634232] Carcinogenesis. 2000 May;21(5):965-71 [10783319] Environ Res. 2000 May;83(1):67-71 [10845783] J Natl Cancer Inst Monogr. 2000;(27):113-24 [10963623] Cancer Epidemiol Biomarkers Prev. 2000 Oct;9(10):1005-15 [11045781] Immunol Today. 2000 Oct;21(10):515-21 [11071531] Ann Agric Environ Med. 2000;7(1):61-3 [10865247] Mutat Res. 2001 Apr 5;491(1-2):71-80 [11287300] Arch Environ Contam Toxicol. 2001 Jul;41(1):104-11 [11385596] Environ Health Perspect. 2001 May;109(5):495-500 [11401761] Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1239-48 [11751440] Mutagenesis. 2002 Jan;17(1):79-82 [11752238] Environ Mol Mutagen. 2002;39(2-3):208-15 [11921191] Free Radic Biol Med. 2002 Jul 1;33(1):37-44 [12086680] Mutagenesis. 2002 Sep;17(5):391-7 [12202626] J Appl Toxicol. 2002 Jul-Aug;22(4):249-55 [12210542] Mutat Res. 2002 Sep 26;520(1-2):83-91 [12297147] Environ Mol Mutagen. 2002;40(3):153-60 [12355548] Cancer Epidemiol Biomarkers Prev. 2003 May;12(5):439-43 [12750239] Mutat Res. 2003 Jun;543(3):251-72 [12787816] Biomedica. 2003 Jun;23(2):141-52 [12872553] Am J Clin Nutr. 2009 Sep;90(3):680-5 [19640946] Mutat Res. 2000 Nov 20;455(1-2):81-95 [11113469] Clin Diagn Lab Immunol. 2004 Jan;11(1):168-73 [14715565] Toxicology. 2004 Feb 15;195(2-3):231-42 [14751678] Mutat Res. 2004 Apr 14;548(1-2):27-33 [15063133] Cancer Genet Cytogenet. 2004 May;151(1):60-7 [15120911] Arch Toxikol. 1971;28(2):105-14 [5123870] Br J Ind Med. 1978 Aug;35(3):232-4 [698138] Br J Ind Med. 1981 Feb;38(1):98-100 [7470409] Ann Occup Hyg. 1981;24(1):77-92 [7015964] Clin Chem. 1985 Apr;31(4):546-50 [3978785] Int Arch Occup Environ Health. 1988;60(6):453-6 [3410555] Br J Ind Med. 1988 Aug;45(8):548-51 [3415921] Br J Ind Med. 1991 Feb;48(2):82-6 [1998612] Immunol Today. 1995 Jan;16(1):12-6 [7880382] Cancer Epidemiol Biomarkers Prev. 1995 Sep;4(6):671-9 [8547835] Lancet. 1996 Jun 29;347(9018):1844 [8667966] Carcinogenesis. 1997 Apr;18(4):641-4 [9111193] Mutat Res. 1998 May 25;400(1-2):467-78 [9685705] Exp Gerontol. 1998 Sep;33(6):593-600 [9789736] Food Chem Toxicol. 2006 Oct;44(10):1714-23 [16814914] Mutat Res. 2006 Oct 10;609(1):74-80 [16887377] Mutagenesis. 2006 Sep;21(5):343-50 [16980312] Environ Mol Mutagen. 2006 Oct;47(8):587-93 [16917935] J Pathol. 2007 Jan;211(2):144-56 [17200946] Immunology. 2007 Apr;120(4):435-46 [17313487] Int J Hyg Environ Health. 2007 May;210(3-4):415-8 [17320478] Environ Int. 2007 Oct;33(7):877-85 [17493680] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2014.02.011 ER - TY - JOUR T1 - Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum. AN - 1609507281; 25290267 AB - Epigenetic mechanisms regulate programmed gene expression during prenatal neurogenesis and serve as a mediator between genetics and environment in postnatal life. The recent discovery of 5-hydroxymethylcytosine (5-hmC), with highest concentration in the brain, has added a new dimension to epigenetic regulation of neurogenesis and the development of complex behavior disorders. Here, we take a candidate gene approach to define the role 5-hmC in Engrailed-2 (EN-2) gene expression in the autism cerebellum. The EN-2 homeobox transcription factor, previously implicated in autism, is essential for normal cerebellar patterning and development. We previously reported EN-2 overexpression associated with promoter DNA hypermethylation in the autism cerebellum but because traditional DNA methylation methodology cannot distinguish 5-methylcytosine (5-mC) from 5-hmC, we now extend our investigation by quantifying global and gene-specific 5-mC and 5-hmC. Globally, 5-hmC was significantly increased in the autism cerebellum and accompanied by increases in the expression of de novo methyltransferases DNMT3A and DNMT3B, ten-eleven translocase genes TET1 and TET3, and in 8-oxo-deoxyguanosine (8-oxo-dG) content, a marker of oxidative DNA damage. Within the EN-2 promoter, there was a significant positive correlation between 5-hmC content and EN-2 gene expression. Based on reports of reduced MeCP2 affinity for 5-hmC, MeCP2 binding studies in the EN-2 promoter revealed a significant decrease in repressive MeCP2 binding that may contribute to the aberrant overexpression of EN-2. Because normal cerebellar development depends on perinatal EN-2 downregulation, the sustained postnatal overexpression suggests that a critical window of cerebellar development may have been missed in some individuals with autism with downstream developmental consequences. Epigenetic regulation of the programmed on-off switches in gene expression that occur at birth and during early brain development warrants further investigation. JF - Translational psychiatry AU - James, S J AU - Shpyleva, S AU - Melnyk, S AU - Pavliv, O AU - Pogribny, I P AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA. Y1 - 2014/10/07/ PY - 2014 DA - 2014 Oct 07 SP - 1 VL - 4 KW - Homeodomain Proteins KW - 0 KW - Methyl-CpG-Binding Protein 2 KW - Nerve Tissue Proteins KW - engrailed 2 protein KW - 5-hydroxymethylcytosine KW - 1123-95-1 KW - Cytosine KW - 8J337D1HZY KW - Index Medicus KW - Humans KW - Promoter Regions, Genetic -- genetics KW - Adolescent KW - Male KW - Female KW - Methyl-CpG-Binding Protein 2 -- genetics KW - Homeodomain Proteins -- genetics KW - Gene Expression -- genetics KW - Autistic Disorder -- genetics KW - Nerve Tissue Proteins -- genetics KW - Cytosine -- analogs & derivatives KW - Autistic Disorder -- metabolism KW - Cytosine -- metabolism KW - Cerebellum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1609507281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Translational+psychiatry&rft.atitle=Elevated+5-hydroxymethylcytosine+in+the+Engrailed-2+%28EN-2%29+promoter+is+associated+with+increased+gene+expression+and+decreased+MeCP2+binding+in+autism+cerebellum.&rft.au=James%2C+S+J%3BShpyleva%2C+S%3BMelnyk%2C+S%3BPavliv%2C+O%3BPogribny%2C+I+P&rft.aulast=James&rft.aufirst=S&rft.date=2014-10-07&rft.volume=4&rft.issue=&rft.spage=e460&rft.isbn=&rft.btitle=&rft.title=Translational+psychiatry&rft.issn=2158-3188&rft_id=info:doi/10.1038%2Ftp.2014.87 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-02 N1 - Date created - 2014-10-08 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Neurosci. 1998 Mar 1;18(5):1763-73 [9465001] Mol Cell Neurosci. 2005 Jan;28(1):96-105 [15607945] Nat Rev Genet. 2006 Jun;7(6):415-26 [16708070] Mol Cell Biol. 2006 Jul;26(13):5033-42 [16782889] Brain Res. 2006 Oct 20;1116(1):166-76 [16935268] Behav Brain Res. 2007 Jan 10;176(1):121-32 [17055592] Mol Cell Neurosci. 2008 Aug;38(4):495-504 [18562208] Brain Res. 2008 Oct 27;1237:25-34 [18694733] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39 [19412858] Science. 2009 May 15;324(5929):929-30 [19372393] Chem Res Toxicol. 2009 May;22(5):788-97 [19309085] Cerebellum. 2009 Sep;8(3):366-72 [19357934] Nature. 2009 Sep 10;461(7261):199-205 [19741700] Biol Psychiatry. 2009 Nov 15;66(10):911-7 [19615670] Development. 2010 Feb;137(3):519-29 [20081196] BMC Neurosci. 2010;11:53 [20420693] Nucleic Acids Res. 2010 Jun;38(11):e125 [20371518] Genes Dev. 2011 Apr 1;25(7):679-84 [21460036] Nature. 2011 May 19;473(7347):394-7 [21552279] Epigenetics. 2011 Jul;6(7):853-6 [21617369] Neural Plast. 2011;2011:921680 [21826280] Nat Neurosci. 2011 Dec;14(12):1607-16 [22037496] Cancer Res. 2011 Dec 15;71(24):7360-5 [22052461] J Clin Exp Neuropsychol. 2012;34(1):35-56 [22047489] Nucleic Acids Res. 2012 Apr;40(7):2884-97 [22144686] Restor Neurol Neurosci. 2012;30(3):237-45 [22426040] Nucleic Acids Res. 2012 Jun;40(11):4841-9 [22362737] J Neurosci. 2012 Jun 6;32(23):7832-42 [22674259] Cerebellum. 2012 Sep;11(3):777-807 [22370873] Epigenomics. 2012 Aug;4(4):445-57 [22920183] Nucleic Acids Res. 2012 Sep 1;40(17):8255-65 [22730288] J Biol Chem. 2012 Sep 28;287(40):33116-21 [22898819] Cell. 2012 Dec 21;151(7):1417-30 [23260135] Transl Psychiatry. 2013;3:e232 [23423141] Cell Rep. 2013 Feb 21;3(2):291-300 [23403289] Nat Rev Mol Cell Biol. 2013 Jun;14(6):341-56 [23698584] Science. 2013 Aug 9;341(6146):1237905 [23828890] Mech Ageing Dev. 2013 Oct;134(10):486-95 [24012631] Transl Psychiatry. 2014;4:e349 [24448211] Neurobiol Aging. 2014 Jun;35(6):1334-44 [24387984] Mutat Res Genet Toxicol Environ Mutagen. 2014 Apr;764-765:18-35 [24045206] Genome Biol. 2014;15(3):R49 [24594098] PLoS One. 2011;6(4):e18844 [21526191] Environ Health Perspect. 2000 Jun;108 Suppl 3:511-33 [10852851] J Neurosci. 2001 Feb 1;21(3):788-97 [11157065] J Nutr. 2002 Aug;132(8 Suppl):2401S-2405S [12163700] J Comp Neurol. 2004 Apr 19;472(1):87-99 [15024754] Am J Med Genet B Neuropsychiatr Genet. 2004 May 15;127B(1):51-9 [15108180] Nucleic Acids Res. 2004;32(14):4100-8 [15302911] J Mol Biol. 1992 May 20;225(2):327-48 [1317461] J Biol Chem. 1993 Jan 5;268(1):613-9 [8093246] Development. 1996 Feb;122(2):627-35 [8625814] Chem Biol Interact. 1996 Jan 5;99(1-3):289-99 [8620576] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/tp.2014.87 ER - TY - JOUR T1 - Characterization of Cross-Protection by Genetically Modified Live-Attenuated Leishmania donovani Parasites against Leishmania mexicana AN - 1808642749; PQ0003449461 AB - Previously, we showed that genetically modified live-attenuated Leishmania donovani parasite cell lines (LdCen-/- and Ldp27-/-) induce a strong cellular immunity and provide protection against visceral leishmaniasis in mice. In this study, we explored the mechanism of cross-protection against cutaneous lesion-causing Leishmania mexicana. Upon challenge with wild-type L. mexicana, mice immunized either for short or long periods showed significant protection. Immunohistochemical analysis of ears from immunized/challenged mice exhibited significant influx of macrophages, as well as cells expressing MHC class II and inducible NO synthase, suggesting an induction of potent host-protective proinflammatory responses. In contrast, substantial inhibition of IL-10, IL-4, and IL-13 expression and the absence of degranulated mast cells and less influx of eosinophils within the ears of immunized/challenged mice suggested a controlled anti-inflammatory response. L. mexicana Ag-stimulated lymph node cell culture from the immunized/challenged mice revealed induction of IFN- gamma secretion by the CD4 and CD8 T cells compared with non-immunized/challenged mice. We also observed suppression of Th2 cytokines in the culture supernatants of immunized/challenged lymph nodes compared with non-immunized/challenged mice. Adoptively transferred total T cells from immunized mice conferred strong protection in recipient mice against L. mexicana infection, suggesting that attenuated L. donovani can provide protection against heterologous L. mexicana parasites by induction of a strong T cell response. Furthermore, bone marrow-derived dendritic cells infected with LdCen-/- and Ldp27-/- parasites were capable of inducing a strong proinflammatory response leading to the proliferation of Th1 cells. These studies demonstrate the potential of live-attenuated L. donovani parasites as pan-Leishmania species vaccines. JF - Journal of Immunology AU - Dey, Ranadhir AU - Natarajan, Gayathri AU - Bhattacharya, Parna AU - Cummings, Hannah AU - Dagur, Pradeep K AU - Terrazas, Cesar AU - Selvapandiyan, Angamuthu AU - McCoy, John P AU - Duncan, Robert AU - Satoskar, Abhay R AU - Nakhasi, Hira L AD - Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993 Y1 - 2014/10/01/ PY - 2014 DA - 2014 Oct 01 SP - 3513 EP - 3527 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 United States VL - 193 IS - 7 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Macrophages KW - Parasites KW - gamma -Interferon KW - Interleukin 4 KW - Cross-protection KW - Helper cells KW - Bone marrow KW - Major histocompatibility complex KW - Cell culture KW - Ear KW - Leukocytes (eosinophilic) KW - Infection KW - Interleukin 10 KW - Leishmania donovani KW - Dendritic cells KW - Interleukin 13 KW - CD4 antigen KW - Lymphocytes T KW - Cytokines KW - Visceral leishmaniasis KW - Mast cells KW - CD8 antigen KW - Lymph nodes KW - Inflammation KW - Nitric-oxide synthase KW - Immunity (cell-mediated) KW - Vaccines KW - Leishmania mexicana KW - Cell proliferation KW - K 03350:Immunology KW - G 07790:Other Microorganisms KW - F 06915:Cancer Immunology KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808642749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Characterization+of+Cross-Protection+by+Genetically+Modified+Live-Attenuated+Leishmania+donovani+Parasites+against+Leishmania+mexicana&rft.au=Dey%2C+Ranadhir%3BNatarajan%2C+Gayathri%3BBhattacharya%2C+Parna%3BCummings%2C+Hannah%3BDagur%2C+Pradeep+K%3BTerrazas%2C+Cesar%3BSelvapandiyan%2C+Angamuthu%3BMcCoy%2C+John+P%3BDuncan%2C+Robert%3BSatoskar%2C+Abhay+R%3BNakhasi%2C+Hira+L&rft.aulast=Dey&rft.aufirst=Ranadhir&rft.date=2014-10-01&rft.volume=193&rft.issue=7&rft.spage=3513&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/10.4049%2Fjimmunol.1303145 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-14 N1 - SubjectsTermNotLitGenreText - Macrophages; gamma -Interferon; Parasites; Interleukin 4; Cross-protection; Helper cells; Bone marrow; Major histocompatibility complex; Ear; Cell culture; Leukocytes (eosinophilic); Infection; Interleukin 10; Dendritic cells; CD4 antigen; Interleukin 13; Lymphocytes T; Cytokines; Visceral leishmaniasis; Mast cells; CD8 antigen; Lymph nodes; Inflammation; Nitric-oxide synthase; Immunity (cell-mediated); Vaccines; Cell proliferation; Leishmania donovani; Leishmania mexicana DO - http://dx.doi.org/10.4049/jimmunol.1303145 ER - TY - JOUR T1 - Postscript: Research Agenda to Guide the Next Generation of Public Reports for Consumers AN - 1683509492 AB - There is significant interest in building the next generation of public reporting tools that will more effectively engage consumers and better enable them to make use of comparative performance information when selecting a provider. Demand for public reporting tools that make health care cost and quality information transparent is fueled by a variety of market forces underway. A host of public reporting efforts and studies have identified a number of challenges, highlighting that we still do not understand how best to design public reports to meet the needs of the consumer. We identify five areas for additional research that, if addressed, could foster better design and delivery of quality and cost information to consumers. JF - Medical Care Research and Review : MCRR AU - Damberg, Cheryl L AU - McNamara, Peggy AD - RAND Corporation, Santa Monica, CA, USA ; Agency for Healthcare Research and Quality, Rockville, MD, USA ; RAND Corporation, Santa Monica, CA, USA Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 97S EP - 107S CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 71 IS - 5 SN - 1077-5587 KW - Public Health And Safety KW - consumer engagement in quality KW - public reporting KW - report cards KW - transparency KW - health care decision making KW - Consumers KW - Decision making KW - Health care KW - Health costs KW - Market forces KW - Transparency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683509492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review+%3A+MCRR&rft.atitle=Postscript%3A+Research+Agenda+to+Guide+the+Next+Generation+of+Public+Reports+for+Consumers&rft.au=Damberg%2C+Cheryl+L%3BMcNamara%2C+Peggy&rft.aulast=Damberg&rft.aufirst=Cheryl&rft.date=2014-10-01&rft.volume=71&rft.issue=5&rft.spage=97S&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review+%3A+MCRR&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558714535982 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-05-14 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.1177/1077558714535982 ER - TY - JOUR T1 - Statistical challenges in drug approval trials that use patient-reported outcomes* AN - 1683509220 AB - This article describes challenging aspects of the use of patient-reported outcome instruments in clinical trials for drug approval, in our perspective as statistical reviewers at the US Food and Drug Administration. We discuss aspects of planning and interpreting results in clinical trials (1) adapting an existing patient-reported outcome instrument for use in clinical trials, (2) using multi-item patient-reported outcomes and (3) missing patient-reported outcome values from many subjects over time. These challenges are illustrated with multiple examples from different clinical trials for different indications. We finally discuss important considerations in labeling. JF - Statistical Methods in Medical Research AU - Izem, Rima AU - Kammerman, Lisa A AU - Komo, Scott AD - Center for Drug Evaluations and Research, Food and Drug Administration, Silver Spring, MD, USA ; Center for Drug Evaluations and Research, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 398 EP - 408 CY - London PB - Sage Publications Ltd. VL - 23 IS - 5 SN - 0962-2802 KW - Medical Sciences KW - Patient-reported outcome KW - statistical review KW - Clinical research KW - Clinical trials KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683509220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Statistical+challenges+in+drug+approval+trials+that+use+patient-reported+outcomes*&rft.au=Izem%2C+Rima%3BKammerman%2C+Lisa+A%3BKomo%2C+Scott&rft.aulast=Izem&rft.aufirst=Rima&rft.date=2014-10-01&rft.volume=23&rft.issue=5&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280213476376 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Food & Drug Administration--FDA N1 - Date revised - 2015-05-12 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1177/0962280213476376 ER - TY - JOUR T1 - Public Reporting of Provider Performance at a Crossroads in the United States: Summary of Current Barriers and Recommendations on How to Move Forward AN - 1683508455 AB - Twenty-seven years after the first public release by the U.S. government of data on the quality of hospital care, public reporting for consumers has expanded substantially. Despite the growth in public reporting activities, there is limited evidence of their use by consumers in ways that significantly affect health care delivery. Support for public reporting continues, in part, because of the face value of transparency. The limited impact of reporting efforts is plausibly due to flaws in the content, design, and implementation of existing public reports rather than inherent limitations of reporting. Substantial work is still needed for public reports to achieve their potential for engaging and informing consumers. We present a vision statement and 10 recommendations to achieve this potential. JF - Medical Care Research and Review : MCRR AU - Hussey, Peter S AU - Luft, Harold S AU - McNamara, Peggy AD - RAND Corporation, Boston, MA, USA ; Palo Alto Medical Foundation, Palo Alto, CA, USA ; Agency for Healthcare Research and Quality, Rockville, MD, USA ; RAND Corporation, Boston, MA, USA Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 5S EP - 16S CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 71 IS - 5 SN - 1077-5587 KW - Public Health And Safety KW - consumer engagement in quality KW - public reporting KW - report cards KW - transparency KW - health care decision making KW - Care delivery KW - Consumers KW - Decision making KW - Health care KW - Release KW - Service delivery KW - Transparency KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683508455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review+%3A+MCRR&rft.atitle=Public+Reporting+of+Provider+Performance+at+a+Crossroads+in+the+United+States%3A+Summary+of+Current+Barriers+and+Recommendations+on+How+to+Move+Forward&rft.au=Hussey%2C+Peter+S%3BLuft%2C+Harold+S%3BMcNamara%2C+Peggy&rft.aulast=Hussey&rft.aufirst=Peter&rft.date=2014-10-01&rft.volume=71&rft.issue=5&rft.spage=5S&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review+%3A+MCRR&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558714535980 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-05-15 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1177/1077558714535980 ER - TY - JOUR T1 - Diversity of Desulfobacteriaceae and Overall Activity of Sulfate-Reducing Microorganisms in and Around a Salt pan in a Southern California Coastal Wetland AN - 1647022998; 21172874 AB - Sulfate-reducing bacteria (SRB) are key mediators of anaerobic carbon cycling in coastal salt marsh sediments and have been shown to be important decomposer communities even in hypersaline habitats. Understanding how SRB function in various salt marsh habitats (vegetated, salt pans) is crucial to advancing our knowledge of salt marsh function. We compare overall sulfate reducing activity and the diversity of a subset of SRB (Desulfobacteriaceae) in two hypersaline sediments (salt pan and nearby area with desiccated vegetation) with a regularly inundated control site within the Huntington Beach Wetlands (HBW). Biological activity was quantified using radiotracer studies to measure sulfate reduction rates (SRR) with and without carbon amendment. All sites showed enhanced SRR under carbon amendment, suggesting short-term carbon limitation. Unique communities of Desulfobacteriaceae were found in all three sites with increased incidence of halotolerant genotypes in the salt pan. These findings indicate that, despite reduced anaerobic respiratory activity, highly diverse and functional deltaproteobacterial communities exist in salt pan and surrounding hypersaline habitats in coastal salt marshes in southern California. JF - Wetlands AU - Jackson, Karen L AU - Whitcraft, Christine R AU - Dillon, Jesse G AD - Department of Biological Sciences, California State University, 1250 Bellflower Blvd., Long Beach, CA, 90840, USA; United States Food and Drug Administration, 19701 Fairchild, Irvine, CA, 92603, USA Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 969 EP - 977 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 34 IS - 5 SN - 0277-5212, 0277-5212 KW - Meteorological & Geoastrophysical Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Ecology Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Coastal salt pan KW - Desulfobacteriaceae KW - Sulfate?-reducing bacteria KW - Sulfate reduction KW - Salt marshes KW - Anaerobic respiration KW - Genotypes KW - Diving physiology KW - Carbon KW - INE, USA, California, Huntington Beach KW - Decomposers KW - Wetlands KW - Sediment chemistry KW - Sulfate-reducing bacteria KW - Beaches KW - Carbon cycle KW - Vegetation KW - Salinity tolerance KW - Habitat KW - Sediments KW - Salts KW - Coastal zone KW - Species diversity KW - Microorganisms KW - Pans KW - Q1 08463:Habitat community studies KW - O 1010:Viruses, Bacteria, Protists, Fungi and Plants KW - A 01450:Environmental Pollution & Waste Treatment KW - D 04040:Ecosystem and Ecology Studies KW - M2 556.56:Swamps, Marshes (556.56) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647022998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wetlands&rft.atitle=Diversity+of+Desulfobacteriaceae+and+Overall+Activity+of+Sulfate-Reducing+Microorganisms+in+and+Around+a+Salt+pan+in+a+Southern+California+Coastal+Wetland&rft.au=Jackson%2C+Karen+L%3BWhitcraft%2C+Christine+R%3BDillon%2C+Jesse+G&rft.aulast=Jackson&rft.aufirst=Karen&rft.date=2014-10-01&rft.volume=34&rft.issue=5&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=Wetlands&rft.issn=02775212&rft_id=info:doi/10.1007%2Fs131570140560z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Sediment chemistry; Anaerobic respiration; Coastal zone; Salt marshes; Species diversity; Microorganisms; Decomposers; Wetlands; Diving physiology; Beaches; Sulfate-reducing bacteria; Sulfate reduction; Carbon cycle; Vegetation; Salinity tolerance; Genotypes; Habitat; Sediments; Salts; Carbon; Pans; Desulfobacteriaceae; INE, USA, California, Huntington Beach DO - http://dx.doi.org/10.1007/s131570140560z ER - TY - JOUR T1 - Prevalence of Chronic Obstructive Pulmonary Disease Among US Working Adults Aged 40 to 70 Years: National Health Interview Survey Data 2004 to 2011 AN - 1627961296; 20921234 AB - Objective: To estimate the prevalence and prevalence odds ratios of chronic obstructive pulmonary disease (COPD) among US workers by major occupational groups. Methods: The 2004 to 2011 National Health Interview Survey data for working adults 40 to 70 years old was analyzed to estimate the prevalence of COPD by major occupational groups. Logistic regression models were used to evaluate the associations between COPD (chronic bronchitis or emphysema) and occupations. Results: The estimated overall COPD prevalence was 4.2% (95% CI, 4.0 to 4.3). The odds of COPD were highest among workers in health care support occupations (prevalence odds ratio, 1.64; 95% CI, 1.25 to 2.14) followed by food preparation and serving-related occupations (prevalence odds ratio, 1.57; 95% CI, 1.20 to 2.06). Conclusions: Prevalence varied by occupations, suggesting workplace exposures may contribute to COPD. Preventive measures such as interventions to reduce smoking may reduce the prevalence of COPD. JF - Journal of Occupational and Environmental Medicine AU - Doney, Brent AU - Hnizdo, Eva AU - Syamlal, Girija AU - Kullman, Greg AU - Burchfiel, Cecil AU - Martin, Christopher J AU - Mujuru, Priscah AD - Division of Respiratory Disease Studies, Surveillance Branch, National Institute for Occupational Safety and Health, Mailstop HG 900.2, 1095 Willowdale Rd., Morgantown, WV 26505, bdoney@cdc.gov Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 1088 EP - 1093 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 56 IS - 10 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Smoking KW - Health care KW - Intervention KW - Occupational exposure KW - Chronic obstructive pulmonary disease KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627961296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Prevalence+of+Chronic+Obstructive+Pulmonary+Disease+Among+US+Working+Adults+Aged+40+to+70+Years%3A+National+Health+Interview+Survey+Data+2004+to+2011&rft.au=Doney%2C+Brent%3BHnizdo%2C+Eva%3BSyamlal%2C+Girija%3BKullman%2C+Greg%3BBurchfiel%2C+Cecil%3BMartin%2C+Christopher+J%3BMujuru%2C+Priscah&rft.aulast=Doney&rft.aufirst=Brent&rft.date=2014-10-01&rft.volume=56&rft.issue=10&rft.spage=1088&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000232 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Smoking; Health care; Intervention; Occupational exposure; Chronic obstructive pulmonary disease DO - http://dx.doi.org/10.1097/JOM.0000000000000232 ER - TY - JOUR T1 - Preferences for patient medication information: what do patients want? AN - 1625336814; 4618328 AB - This study investigated respondent preferences on how best to display patient medication information (PMI) that accompanies prescription medications to promote comprehension and appropriate usage. The authors identified 30 individuals diagnosed with select immune disorders, 30 with other chronic diseases, and 30 from the general public and had them review one of two PMI handouts that varied by format, organization, and content. The authors explored preferences for the PMI handout using one-on-one interviews. The authors analyzed the qualitative data to identify relevant themes and patterns using NVivo9 qualitative software. The majority of respondents noted that the formats of the two PMI handouts were more informative than those they currently receive from the pharmacist, with a preference for the 2-column, segmented design. However, respondent PMI preferences varied by age, education, and health status. Patients need simpler and more concise drug information to make better decisions about their health. Current PMI handouts are dense and complex, which can be confusing and not reader friendly. To improve PMI understandability and usefulness, the U.S. Food and Drug Administration is working with stakeholders, consumer advocates, and academics. Findings from this study may help inform future development of more user- friendly PMI. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Kish-Doto, Julia AU - Scales, Monica AU - Eguino-Medina, Paula AU - Fitzgerald, Tania AU - Tzeng, Janice P AU - McCormack, Lauren A AU - Donoghue, Amie O' AU - Oguntimein, Oluwamurewa AU - West, Suzanne L AD - RTI International ; US Food and Drug Administration Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 77 EP - 88 VL - 19 IS - Supp.2 SN - 1081-0730, 1081-0730 KW - Sociology KW - Qualitative analysis KW - Stakeholder KW - Preferences KW - Patients KW - Interviews KW - U.S.A. KW - Health inequality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1625336814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Preferences+for+patient+medication+information%3A+what+do+patients+want%3F&rft.au=Kish-Doto%2C+Julia%3BScales%2C+Monica%3BEguino-Medina%2C+Paula%3BFitzgerald%2C+Tania%3BTzeng%2C+Janice+P%3BMcCormack%2C+Lauren+A%3BDonoghue%2C+Amie+O%27%3BOguntimein%2C+Oluwamurewa%3BWest%2C+Suzanne+L&rft.aulast=Kish-Doto&rft.aufirst=Julia&rft.date=2014-10-01&rft.volume=19&rft.issue=Supp.2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2014.946114 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-11-17 N1 - Last updated - 2014-11-17 N1 - SubjectsTermNotLitGenreText - 9271 7890 5792 10484; 10016; 6832 10919; 12158; 10519 3279 971 3286; 5783 5772 6489; 433 293 14 DO - http://dx.doi.org/10.1080/10810730.2014.946114 ER - TY - JOUR T1 - Combined effect of hyperuricemia and overweight/obesity on the prevalence of hypertension among US adults: result from the National Health and Nutrition Examination Survey AN - 1622611649; 20867438 AB - Hypertension is a large and growing public health problem worldwide. Hyperuricemia and overweight/obesity are two of the most important risk factors for hypertension. However, their combined effect on the risk of hypertension is not known. Participants aged 20 years and older from the National Health and Nutrition Examination Survey from 1999-2012 were used to evaluate the separate and combined effects of hyperuricemia and overweight/obesity on the risk of prevalent hypertension among different race, gender and age groups. Participants (31 473) were used to estimate separate and combined effects on the prevalence of hypertension. The overall prevalence of hypertension among adults with a combination of hyperuricemia and overweight/obesity (50.2%, 95% confidence interval (CI) 48.3-52.1%) was significantly higher than separate hyperuricemia (41.7%, 95% CI 37.2-46.2%) and overweight/obesity (30.6%, 95% CI 29.5-31.8%). The magnitude of odds ratio (OR) from the combination of hyperuricemia and overweight/obesity (OR=4.53, 95% CI 4.05-5.07) was significantly higher than both hyperuricemia (OR=2.62, 95% CI 2.07-3.32) and overweight/obesity (OR=2.08, 95% CI 1.89-2.30). Combined effect of hyperuricemia and overweight/obesity on the risk of hypertension is much stronger than any separate one. These data can provide important information for identification of target populations for future intervention and patient management. JF - Journal of Human Hypertension AU - Han, G-M AU - Gonzalez, S AU - DeVries, D AD - 1] Department of Epidemiology, University of Nebraska Medical Center, Omaha, NE, USA [2] Nebraska Department of Health and Human Services, Lincoln, NE, USA Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 579 EP - 586 PB - Nature Publishing Group VL - 28 IS - 10 SN - 0950-9240, 0950-9240 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Obesity KW - Risk factors KW - Gender KW - Intervention KW - Age groups KW - Nutrition KW - Hypertension KW - Public health KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622611649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Human+Hypertension&rft.atitle=Combined+effect+of+hyperuricemia+and+overweight%2Fobesity+on+the+prevalence+of+hypertension+among+US+adults%3A+result+from+the+National+Health+and+Nutrition+Examination+Survey&rft.au=Han%2C+G-M%3BGonzalez%2C+S%3BDeVries%2C+D&rft.aulast=Han&rft.aufirst=G-M&rft.date=2014-10-01&rft.volume=28&rft.issue=10&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Journal+of+Human+Hypertension&rft.issn=09509240&rft_id=info:doi/10.1038%2Fjhh.2014.31 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Obesity; Risk factors; Gender; Intervention; Age groups; Nutrition; Public health; Hypertension DO - http://dx.doi.org/10.1038/jhh.2014.31 ER - TY - JOUR T1 - In vitroinvestigation of the mutagenic potential of Aloe veraextracts AN - 1618160829; 20853696 AB - A 2-year cancer bioassay in rodents with a preparation of Aloe verawhole leaf extract administered in drinking water showed clear evidence of carcinogenic activity. To provide insight into the identity and mechanisms associated with mutagenic components of the Aloe veraextracts, we used the mouse lymphoma assay to evaluate the mutagenicity of the Aloe verawhole leaf extract (WLE) and Aloe veradecolorized whole leaf extract (WLD). The WLD extract was obtained by subjecting WLE to activated carbon-adsorption. HPLC analysis indicated that the decolorization process removed many components from the WLE extract, including anthraquinones. Both WLE and WLD extracts showed cytotoxic and mutagenic effects in mouse lymphoma cells but in different concentration ranges, and WLD induced about 3-fold higher levels of intracellular reactive oxygen species than WLE. Molecular analysis of mutant colonies from cells treated with WLE and WLD revealed that the primary type of damage from both treatments was largely due to chromosome mutations (deletions and/or mitotic recombination). The fact that the samples were mutagenic at different concentrations suggests that while some mutagenic components of WLE were removed by activated carbon filtration, components with pro-oxidant activity and mutagenic activity remained. The results demonstrate the utility of the mouse lymphoma assay as a tool to characterize the mutagenic activity of fractionated complex botanical mixtures to identify bioactive components. JF - Toxicology Research AU - Guo, Xiaoqing AU - Zhang, Suhui AU - Dial, Stacey L AU - Boudreau, Mary D AU - Xia, Qingsu AU - Fu, Peter P AU - Levy, Dan D AU - Moore, Martha M AU - Mei, Nan AD - Division of Genetic and Molecular Toxicology; National Center for Toxicological Research; Jefferson; AR 72079; USA; +1 (870) 543-7386; , Nan.Mei@fda.hhs.gov Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 487 EP - 496 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 3 IS - 6 SN - 2045-452X, 2045-452X KW - Toxicology Abstracts KW - High-performance liquid chromatography KW - Mutagenicity KW - Aloe KW - anthraquinone KW - Leaves KW - Carbon (activated) KW - Cancer KW - Wld protein KW - Recombination KW - Cytotoxicity KW - Chromosomes KW - Filtration KW - Colonies KW - Reactive oxygen species KW - Chromosome deletion KW - Drinking water KW - Lymphoma KW - Mutation KW - decolorization KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1618160829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Research&rft.atitle=In+vitroinvestigation+of+the+mutagenic+potential+of+Aloe+veraextracts&rft.au=Guo%2C+Xiaoqing%3BZhang%2C+Suhui%3BDial%2C+Stacey+L%3BBoudreau%2C+Mary+D%3BXia%2C+Qingsu%3BFu%2C+Peter+P%3BLevy%2C+Dan+D%3BMoore%2C+Martha+M%3BMei%2C+Nan&rft.aulast=Guo&rft.aufirst=Xiaoqing&rft.date=2014-10-01&rft.volume=3&rft.issue=6&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Toxicology+Research&rft.issn=2045452X&rft_id=info:doi/10.1039%2Fc4tx00053f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-01 N1 - Number of references - 44 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Mutagenicity; anthraquinone; Leaves; Carbon (activated); Wld protein; Cancer; Recombination; Colonies; Filtration; Chromosomes; Cytotoxicity; Reactive oxygen species; Chromosome deletion; Drinking water; Mutation; Lymphoma; decolorization; Aloe DO - http://dx.doi.org/10.1039/c4tx00053f ER - TY - JOUR T1 - Structural determinants for binding, activation, and functional selectivity of the angiotensin AT1 receptor. AN - 1612288569; 25013233 AB - The renin-angiotensin system (RAS) plays an important role in the pathophysiology of cardiovascular disorders. Pharmacologic interventions targeting the RAS cascade have led to the discovery of renin inhibitors, angiotensin-converting enzyme inhibitors, and AT(1) receptor blockers (ARBs) to treat hypertension and some cardiovascular and renal disorders. Mutagenesis and modeling studies have revealed that differential functional outcomes are the results of multiple active states conformed by the AT(1) receptor upon interaction with angiotensin II (Ang II). The binding of agonist is dependent on both extracellular and intramembrane regions of the receptor molecule, and as a consequence occupies more extensive area of the receptor than a non-peptide antagonist. Both agonist and antagonist bind to the same intramembrane regions to interfere with each other's binding to exhibit competitive, surmountable interaction. The nature of interactions with the amino acids in the receptor is different for each of the ARBs given the small differences in the molecular structure between drugs. AT(1) receptors attain different conformation states after binding various Ang II analogues, resulting in variable responses through activation of multiple signaling pathways. These include both classical and non-classical pathways mediated through growth factor receptor transactivations, and provide cross-communication between downstream signaling molecules. The structural requirements for AT(1) receptors to activate extracellular signal-regulated kinases 1 and 2 through G proteins, or G protein-independently through β-arrestin, are different. We review the structural and functional characteristics of Ang II and its analogs and antagonists, and their interaction with amino acid residues in the AT(1) receptor. © 2014 Society for Endocrinology. JF - Journal of molecular endocrinology AU - Balakumar, Pitchai AU - Jagadeesh, Gowraganahalli AD - Pharmacology UnitFaculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, MalaysiaDivision of Cardiovascular and Renal ProductsCenter for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA pbala2006@gmail.com. ; Pharmacology UnitFaculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, MalaysiaDivision of Cardiovascular and Renal ProductsCenter for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - R71 EP - R92 VL - 53 IS - 2 KW - Amino Acids KW - 0 KW - Angiotensin II Type 1 Receptor Blockers KW - Ligands KW - Receptor, Angiotensin, Type 1 KW - Angiotensin II KW - 11128-99-7 KW - Index Medicus KW - angiotensin II KW - renin–angiotensin system KW - AT1 receptor KW - β-arrestin KW - Animals KW - Angiotensin II -- metabolism KW - Humans KW - Angiotensin II Type 1 Receptor Blockers -- pharmacology KW - Protein Interaction Domains and Motifs KW - Protein Binding KW - Signal Transduction KW - Receptor, Angiotensin, Type 1 -- genetics KW - Receptor, Angiotensin, Type 1 -- chemistry KW - Receptor, Angiotensin, Type 1 -- agonists KW - Receptor, Angiotensin, Type 1 -- metabolism KW - Binding Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1612288569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+endocrinology&rft.atitle=Structural+determinants+for+binding%2C+activation%2C+and+functional+selectivity+of+the+angiotensin+AT1+receptor.&rft.au=Balakumar%2C+Pitchai%3BJagadeesh%2C+Gowraganahalli&rft.aulast=Balakumar&rft.aufirst=Pitchai&rft.date=2014-10-01&rft.volume=53&rft.issue=2&rft.spage=R71&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+endocrinology&rft.issn=1479-6813&rft_id=info:doi/10.1530%2FJME-14-0125 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-22 N1 - Date created - 2014-09-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1530/JME-14-0125 ER - TY - JOUR T1 - Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia. AN - 1612287732; 24836729 AB - Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Pharmacology & therapeutics AU - Matsumoto, Rae R AU - Seminerio, Michael J AU - Turner, Ryan C AU - Robson, Matthew J AU - Nguyen, Linda AU - Miller, Diane B AU - O'Callaghan, James P AD - Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA. Electronic address: rmatsumoto@hsc.wvu.edu. ; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Department of Medicine, University of Chicago, Chicago, IL 60637, USA. ; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA; Department of Neurosurgery, School of Medicine, West Virginia University, Morgantown, WV 26506,USA. ; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA. ; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA. ; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 28 EP - 40 VL - 144 IS - 1 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Hyperthermia KW - Autonomic nervous system KW - Reactive oxygen species KW - Thermoregulation KW - Toxicity KW - Body Temperature Regulation -- drug effects KW - Animals KW - Body Temperature -- drug effects KW - Humans KW - Drug Overdose KW - Fever -- chemically induced KW - Methamphetamine -- adverse effects KW - Central Nervous System Stimulants -- adverse effects KW - Methamphetamine -- poisoning KW - Central Nervous System Stimulants -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1612287732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+therapeutics&rft.atitle=Methamphetamine-induced+toxicity%3A+an+updated+review+on+issues+related+to+hyperthermia.&rft.au=Matsumoto%2C+Rae+R%3BSeminerio%2C+Michael+J%3BTurner%2C+Ryan+C%3BRobson%2C+Matthew+J%3BNguyen%2C+Linda%3BMiller%2C+Diane+B%3BO%27Callaghan%2C+James+P&rft.aulast=Matsumoto&rft.aufirst=Rae&rft.date=2014-10-01&rft.volume=144&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+therapeutics&rft.issn=1879-016X&rft_id=info:doi/10.1016%2Fj.pharmthera.2014.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-12 N1 - Date created - 2014-08-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Neurochem. 2010 Nov;115(3):595-605 [20722968] Front Biosci (Landmark Ed). 2011;16:74-104 [21196160] 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AN - 1609309303; 25015656 AB - The development of nephrotoxicity limits the maximum achievable dosage and treatment intervals for cisplatin chemotherapy. Therefore, identifying mechanisms that regulate this toxicity could offer novel methods to optimize cisplatin delivery. MicroRNAs are capable of regulating many different genes, and can influence diverse cellular processes, including cell death and apoptosis. We previously observed miR-155 to be highly increased following ischemic or toxic injury to the kidneys and, therefore, sought to determine whether mice deficient in miR-155 would respond differently to kidney injury. We treated C57BL/6 and miR-155(-/-) mice with 20 mg/kg of cisplatin and found a significantly higher level of kidney injury in the miR-155(-/-) mice. Genome-wide expression profiling and bioinformatic analysis indicated the activation of a number of canonical signaling pathways relating to apoptosis and oxidative stress over the course of the injury, and identified potential upstream regulators of these effects. One predicted upstream regulator was c-Fos, which has two confirmed miR-155 binding sites in its 3' UTR and, therefore, can be directly regulated by miR-155. We established that the miR-155(-/-) mice had significantly higher levels of c-Fos mRNA and protein than the C57BL/6 mice at 72 h after cisplatin exposure. These data indicate a role for miR-155 in the cisplatin response and suggest that targeting of c-Fos could be investigated to reduce cisplatin-induced nephrotoxicity. © The Author 2014. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Pellegrini, Kathryn L AU - Han, Tao AU - Bijol, Vanesa AU - Saikumar, Janani AU - Craciun, Florin L AU - Chen, William W AU - Fuscoe, James C AU - Vaidya, Vishal S AD - Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. ; Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. ; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. ; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, Massachusetts. ; Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, Massachusetts Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts vvaidya@partners.org. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 484 EP - 492 VL - 141 IS - 2 KW - MicroRNAs KW - 0 KW - Mirn155 microRNA, mouse KW - Proto-Oncogene Proteins c-fos KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - microRNA-155 KW - Kidney toxicity KW - cisplatin KW - miRNAs KW - Animals KW - Proto-Oncogene Proteins c-fos -- metabolism KW - Fibrosis KW - Disease Models, Animal KW - Oxidative Stress -- genetics KW - Computational Biology KW - Gene Expression Profiling -- methods KW - Mice, Knockout KW - Apoptosis -- genetics KW - Proto-Oncogene Proteins c-fos -- genetics KW - Signal Transduction -- genetics KW - Mice, Inbred C57BL KW - Up-Regulation KW - Time Factors KW - Male KW - Kidney -- metabolism KW - Acute Kidney Injury -- genetics KW - MicroRNAs -- metabolism KW - Kidney -- pathology KW - MicroRNAs -- genetics KW - Acute Kidney Injury -- pathology KW - Acute Kidney Injury -- chemically induced KW - Acute Kidney Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1609309303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=MicroRNA-155+deficient+mice+experience+heightened+kidney+toxicity+when+dosed+with+cisplatin.&rft.au=Pellegrini%2C+Kathryn+L%3BHan%2C+Tao%3BBijol%2C+Vanesa%3BSaikumar%2C+Janani%3BCraciun%2C+Florin+L%3BChen%2C+William+W%3BFuscoe%2C+James+C%3BVaidya%2C+Vishal+S&rft.aulast=Pellegrini&rft.aufirst=Kathryn&rft.date=2014-10-01&rft.volume=141&rft.issue=2&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu143 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-02 N1 - Date created - 2014-10-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Sci. 2012 Oct;129(2):256-67 [22705808] Am J Pathol. 2012 Sep;181(3):818-28 [22819533] Cancer Gene Ther. 2012 Nov;19(11):773-8 [22996741] J Am Soc Nephrol. 2013 Dec;24(12):1955-65 [23949802] Cell. 2001 Jan 12;104(1):21-32 [11163237] Environ Health Perspect. 2003 Nov;111(15):1819-26 [14630514] Nat Rev Cancer. 2003 Nov;3(11):859-68 [14668816] Cancer Cell. 2003 Dec;4(6):477-82 [14706339] J Biol Chem. 2004 Jun 11;279(24):25313-9 [15078869] Mol Cell Biol. 1996 Jan;16(1):211-8 [8524298] Nat Rev Drug Discov. 2005 Apr;4(4):307-20 [15789122] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Science. 2007 Apr 27;316(5824):604-8 [17463289] Cancer Res. 2007 Oct 1;67(19):9425-34 [17909052] Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16170-5 [17911264] Nucleic Acids Res. 2008 Jan;36(Database issue):D149-53 [18158296] Kidney Int. 2008 May;73(9):994-1007 [18272962] Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2735-40 [19193853] Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5330-5 [19289845] Toxicol In Vitro. 2009 Aug;23(5):780-8 [19383537] Methods Mol Biol. 2009;563:379-98 [19597796] Urology. 2010 Apr;75(4):835-41 [20035975] J Biol Chem. 2010 Jun 4;285(23):17869-79 [20371610] Genome Biol. 2010;11(8):R90 [20799968] Blood. 2011 Apr 28;117(17):4490-500 [21385848] FEBS J. 2011 Jun;278(11):1873-81 [21439021] Dis Markers. 2011;30(4):171-9 [21694443] Blood. 2011 Aug 18;118(7):1934-42 [21685370] Mol Med Rep. 2012 Apr;5(4):949-54 [22307849] Proc Natl Acad Sci U S A. 2012 May 8;109(19):E1153-62 [22509021] Biochem Soc Trans. 2012 Aug;40(4):821-5 [22817741] PLoS One. 2012;7(9):e45628 [23029147] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu143 ER - TY - JOUR T1 - FDA approval summary: crizotinib for the treatment of metastatic non-small cell lung cancer with anaplastic lymphoma kinase rearrangements. AN - 1609306303; 25170012 AB - On August 26, 2011, crizotinib received accelerated approval for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) that is ALK-positive as detected by a test approved by the U.S. Food and Drug Administration (FDA). Approval was based on two single-arm trials demonstrating objective response rates (ORRs) of 50% and 61% and median response durations of 42 and 48 weeks. On November 20, 2013, crizotinib received regular approval based on confirmation of clinical benefit in study A8081007, a randomized trial in 347 patients with ALK-positive advanced NSCLC who had previously received one platinum-containing regimen. Patients were assigned (1:1) to receive crizotinib 250 mg orally twice daily or standard of care (docetaxel or pemetrexed). The primary endpoint was progression-free survival (PFS) determined by independent radiology review; secondary endpoints were ORR and overall survival (OS). PFS was significantly longer in the crizotinib arm, with median PFS of 7.7 and 3.0 months in the crizotinib and chemotherapy arms, respectively, and a 46% absolute increase in ORR but no difference in OS between treatment arms at the interim analysis. The most common adverse drug reactions (>25%) in crizotinib-treated patients were vision disorders, nausea, diarrhea, vomiting, constipation, edema, elevated transaminases, and fatigue. The most serious toxicities of crizotinib were hepatotoxicity, interstitial lung disease or pneumonitis, and QT-interval prolongation. Crizotinib's rapid clinical development program (6 years from identification of ALK rearrangements in a subset of NSCLC to full FDA approval) is a model of efficient drug development in this new era of molecularly targeted oncology therapy. ©AlphaMed Press. JF - The oncologist AU - Kazandjian, Dickran AU - Blumenthal, Gideon M AU - Chen, Huan-Yu AU - He, Kun AU - Patel, Mona AU - Justice, Robert AU - Keegan, Patricia AU - Pazdur, Richard AD - Office of Hematology and Oncology Products and Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA Dickran.kazandjian@fda.hhs.gov. ; Office of Hematology and Oncology Products and Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - e5 EP - 11 VL - 19 IS - 10 KW - Antineoplastic Agents KW - 0 KW - Protein Kinase Inhibitors KW - Pyrazoles KW - Pyridines KW - Taxoids KW - Pemetrexed KW - 04Q9AIZ7NO KW - docetaxel KW - 15H5577CQD KW - crizotinib KW - 53AH36668S KW - Receptor Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - anaplastic lymphoma kinase KW - Index Medicus KW - Molecular targeted therapy KW - EML4-ALK fusion protein KW - Non-small cell lung carcinoma KW - Neoplasm metastasis KW - Crizotinib KW - United States KW - Young Adult KW - United States Food and Drug Administration KW - Aged, 80 and over KW - Humans KW - Drug Approval KW - Adult KW - Treatment Outcome KW - Pemetrexed -- therapeutic use KW - Neoplasm Metastasis KW - Aged KW - Middle Aged KW - Taxoids -- therapeutic use KW - Male KW - Female KW - Receptor Protein-Tyrosine Kinases -- genetics KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- drug therapy KW - Pyrazoles -- adverse effects KW - Pyrazoles -- therapeutic use KW - Pyridines -- therapeutic use KW - Antineoplastic Agents -- adverse effects KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- adverse effects KW - Lung Neoplasms -- genetics KW - Antineoplastic Agents -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Pyridines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1609306303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+approval+summary%3A+crizotinib+for+the+treatment+of+metastatic+non-small+cell+lung+cancer+with+anaplastic+lymphoma+kinase+rearrangements.&rft.au=Kazandjian%2C+Dickran%3BBlumenthal%2C+Gideon+M%3BChen%2C+Huan-Yu%3BHe%2C+Kun%3BPatel%2C+Mona%3BJustice%2C+Robert%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Kazandjian&rft.aufirst=Dickran&rft.date=2014-10-01&rft.volume=19&rft.issue=10&rft.spage=e5&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2014-0241 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-14 N1 - Date created - 2014-10-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Lancet Oncol. 2011 Aug;12(8):735-42 [21783417] J Thorac Oncol. 2011 Sep;6(9):1474-80 [21642865] CA Cancer J Clin. 2013 Jan;63(1):11-30 [23335087] J Clin Oncol. 2013 Mar 10;31(8):1105-11 [23401436] J Clin Oncol. 2013 Mar 10;31(8):981-3 [23401450] N Engl J Med. 2013 Jun 20;368(25):2385-94 [23724913] CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29 [24399786] Nat Biotechnol. 2014 Apr;32(4):323-30 [24714478] Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3314-22 [18089725] Nature. 2007 Aug 2;448(7153):561-6 [17625570] Science. 1994 Mar 4;263(5151):1281-4 [8122112] Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11 [15329413] Health Aff (Millwood). 2011 Jul;30(7):1375-81 [21680577] J Thorac Oncol. 2011 Apr;6(4):774-80 [21336183] Lancet Oncol. 2011 Feb;12(2):175-80 [21277552] Clin Cancer Res. 2014 Apr 15;20(8):2029-34 [24573551] Nat Rev Clin Oncol. 2009 Jun;6(6):352-66 [19483740] J Clin Oncol. 2004 May 1;22(9):1589-97 [15117980] N Engl J Med. 2010 Oct 28;363(18):1693-703 [20979469] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1634/theoncologist.2014-0241 ER - TY - JOUR T1 - Recombinant Deamidated Mutants of Erwinia chrysanthemi l-Asparaginase Have Similar or Increased Activity Compared to Wild-Type Enzyme AN - 1566832830; 20705463 AB - The enzyme Erwinia chrysanthemi l-asparaginase (ErA) is an important biopharmaceutical product used in the treatment of acute lymphoblastic leukaemia. Like all proteins, certain asparagine (Asn) residues of ErA are susceptible to deamidation to aspartic acid (Asp), which may be a concern with respect to enzyme activity and potentially to pharmaceutical efficacy. Recombinant ErA mutants containing Asn to Asp changes were expressed, purified and characterised. Two mutants with single deamidation sites (N41D and N281D) were found to have approximately the same specific activity (1,062 and 924 U/mg, respectively) as the wild-type (908 U/mg). However, a double mutant (N41D N281D) had an increased specific activity (1261 U/mg). The N41D mutation conferred a slight increase in the catalytic constant (k sub(cat) 657 s super(-1)) when compared to the WT (k sub(cat) 565 s super(-1)), which was further increased in the double mutant, with a k sub(cat) of 798 s super(-1). Structural analyses showed that the slight changes caused by point mutation of Asn sub(41) to Asp may have reduced the number of hydrogen bonds in this alpha -helical part of the protein structure, resulting in subtle changes in enzyme turnover, both structurally and catalytically. The increased alpha -helical content observed with the N41D mutation by circular dichroism spectroscopy correlates with the difference in k sub(cat), but not K sub(m). The N281D mutation resulted in a lower glutaminase activity compared with WT and the N41D mutant, however the N281D mutation also imparted less stability to the enzyme at elevated temperatures. Taken as a whole, these data suggest that ErA deamidation at the Asn sub(41) and Asn sub(281) sites does not affect enzyme activity and should not be a concern during processing, storage or clinical use. The production of recombinant deamidated variants has proven an effective and powerful means of studying the effect of these changes and may be a useful strategy for other biopharmaceutical products. JF - Molecular Biotechnology AU - Gervais, David AU - Foote, Nicholas AD - Microbiology Services, Development & Production, Public Health England, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK, dave.gervais@phe.gov.uk Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 865 EP - 877 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 56 IS - 10 SN - 1073-6085, 1073-6085 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Aspartic acid KW - Data processing KW - Point mutation KW - Enzymes KW - L-asparaginase KW - Spectroscopy KW - Asparagine KW - Protein structure KW - Hydrogen bonding KW - C.D. KW - Acute lymphatic leukemia KW - Glutaminase KW - Erwinia chrysanthemi KW - Pharmaceuticals KW - J 02410:Animal Diseases KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566832830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biotechnology&rft.atitle=Recombinant+Deamidated+Mutants+of+Erwinia+chrysanthemi+l-Asparaginase+Have+Similar+or+Increased+Activity+Compared+to+Wild-Type+Enzyme&rft.au=Gervais%2C+David%3BFoote%2C+Nicholas&rft.aulast=Gervais&rft.aufirst=David&rft.date=2014-10-01&rft.volume=56&rft.issue=10&rft.spage=865&rft.isbn=&rft.btitle=&rft.title=Molecular+Biotechnology&rft.issn=10736085&rft_id=info:doi/10.1007%2Fs12033-014-9766-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 55 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Temperature effects; Data processing; Aspartic acid; Point mutation; Enzymes; L-asparaginase; Spectroscopy; Asparagine; Protein structure; Hydrogen bonding; Glutaminase; Acute lymphatic leukemia; C.D.; Pharmaceuticals; Erwinia chrysanthemi DO - http://dx.doi.org/10.1007/s12033-014-9766-9 ER - TY - JOUR T1 - Impact of study design on the evaluation of inhaled and intranasal corticosteroids' effect on hypothalamic-pituitary-adrenal axis function. AN - 1566110638; 25103275 AB - In part I of this review, an overview of the designs of hypothalamic-pituitary-adrenal (HPA) axis studies in the setting of inhaled corticosteroids (ICS) or intranasal corticosteroids (INS) use was discussed. Part II provides detailed discussion on the HPA axis evaluation results for each common ICS and INS, and how these results are possibly affected by the factors of study design. Significant adrenal suppression at conventional ICS/INS doses appears to be rare in clinical settings. The magnitude of cortisol suppression varies widely among different study designs. Factors potentially impacting this variability include: the choice of dose, dosing duration, assay sensitivity, statistical methodology, study population, and compliance. All of these factors have the potential to affect the extent of HPA axis effects detected and should be considered when designing or interpreting the results of a HPA axis study. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association. JF - Journal of pharmaceutical sciences AU - Fan, Ying AU - Ma, Lian AU - Pippins, Jennifer AU - Limb, Susan AU - Xu, Yun AU - Sahajwalla, Chandrahas G AD - Division of Clinical Pharmacology II, Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, Maryland. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 2963 EP - 2979 VL - 103 IS - 10 KW - Adrenal Cortex Hormones KW - 0 KW - Index Medicus KW - inhaled corticosteroids KW - pediatrics KW - toxicity KW - study design KW - pulmonary KW - hypothalamic-pituitary-adrenal (HPA) axis KW - pharmacodynamics KW - intranasal corticosteroids KW - regulatory science KW - Humans KW - Administration, Intranasal KW - Adult KW - Adolescent KW - Administration, Inhalation KW - Hypothalamo-Hypophyseal System -- drug effects KW - Adrenal Cortex Hormones -- pharmacology KW - Adrenal Cortex Hormones -- administration & dosage KW - Pituitary-Adrenal System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566110638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=Impact+of+study+design+on+the+evaluation+of+inhaled+and+intranasal+corticosteroids%27+effect+on+hypothalamic-pituitary-adrenal+axis+function.&rft.au=Fan%2C+Ying%3BMa%2C+Lian%3BPippins%2C+Jennifer%3BLimb%2C+Susan%3BXu%2C+Yun%3BSahajwalla%2C+Chandrahas+G&rft.aulast=Fan&rft.aufirst=Ying&rft.date=2014-10-01&rft.volume=103&rft.issue=10&rft.spage=2963&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=1520-6017&rft_id=info:doi/10.1002%2Fjps.24089 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-01 N1 - Date created - 2014-09-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jps.24089 ER - TY - JOUR T1 - Signal detection for Thai traditional medicine: examination of national pharmacovigilance data using reporting odds ratio and reported population attributable risk. AN - 1561974862; 24945744 AB - Herbal containing medicine consumption has increased while the awareness of adverse drug reaction (ADR) was less than conventional medicine. Early detection of unexpected numbers of ADRs from herbal medicines' reports which are abnormal from the whole database needs quantification. Disproportionality analysis has been performed for signal detection by using reporting odds ratio (ROR) as measurement. The impact of having medicine as exposures in each ADR should be measured by using reported population attributable risks (RPAR). This study aimed to quantify the contribution of Thai traditional medicine (TTM) to ADR reports and to assess the association between TTMs and serious adverse drug reactions. Data were retrieved from the adverse drug reaction surveillance database, Thai-Food and Drug Administration from 2002 to 2013. Crude and adjusted RORs for each drug-ADR pair and RPARs were computed. TTM contributed only 0.001% of all serious ADRs reported. Out of 4208 TTM-ADR pairs were examined, three had the statistically significant RORs, namely Andrographis paniculata and anaphylactic shock (ROR 2.32, 95% CI 1.03, 5.21); green traditional medicine and Stevens-Johnson syndrome (ROR 13.04, 95% CI 5.4-31.51) and Derris scandens Benth and angioedema (ROR 2.71, 95% CI 1.05-6.95). Their RPARs ranged from 0.05% to 0.16%. We conclude that TTMs need more intensive surveillance. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Wechwithan, Sareeya AU - Suwankesawong, Wimon AU - Sornsrivichai, Vorasith AU - McNeil, Edward B AU - Jiraphongsa, Chuleeporn AU - Chongsuvivatwong, Virasakdi AD - Health Product Vigilance Center, Food and Drug Administration, Ministry of Public Health, 11000, Thailand; Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand. ; Health Product Vigilance Center, Food and Drug Administration, Ministry of Public Health, 11000, Thailand. ; Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand. ; Field Epidemiology Training Program (FETP), Bureau of Epidemiology, Department of Disease Control, Ministry of Public Health, 11000, Thailand. ; Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand. Electronic address: cvirasak@medicine.psu.ac.th. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 407 EP - 412 VL - 70 IS - 1 KW - Plant Preparations KW - 0 KW - Index Medicus KW - Reporting odds ratio KW - ADR KW - Serious ADR KW - Herbal medicine KW - Thai traditional medicine KW - Odds Ratio KW - Humans KW - Databases, Factual KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Thailand -- epidemiology KW - Medicine, East Asian Traditional -- adverse effects KW - Pharmacovigilance KW - Plant Preparations -- adverse effects KW - Drug-Related Side Effects and Adverse Reactions -- etiology KW - Drug-Related Side Effects and Adverse Reactions -- epidemiology KW - Plants, Medicinal -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561974862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Signal+detection+for+Thai+traditional+medicine%3A+examination+of+national+pharmacovigilance+data+using+reporting+odds+ratio+and+reported+population+attributable+risk.&rft.au=Wechwithan%2C+Sareeya%3BSuwankesawong%2C+Wimon%3BSornsrivichai%2C+Vorasith%3BMcNeil%2C+Edward+B%3BJiraphongsa%2C+Chuleeporn%3BChongsuvivatwong%2C+Virasakdi&rft.aulast=Wechwithan&rft.aufirst=Sareeya&rft.date=2014-10-01&rft.volume=70&rft.issue=1&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.06.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-15 N1 - Date created - 2014-09-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.06.007 ER - TY - JOUR T1 - Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials. AN - 1561974351; 25078890 AB - An international expert group which includes 30 organisations (pharmaceutical companies, contract research organisations, academic institutions and regulatory bodies) has shared data on the use of recovery animals in the assessment of pharmaceutical safety for early development. These data have been used as an evidence-base to make recommendations on the inclusion of recovery animals in toxicology studies to achieve scientific objectives, while reducing animal use. Recovery animals are used in pharmaceutical development to provide information on the potential for a toxic effect to translate into long-term human risk. They are included on toxicology studies to assess whether effects observed during dosing persist or reverse once treatment ends. The group devised a questionnaire to collect information on the use of recovery animals in general regulatory toxicology studies to support first-in-human studies. Questions focused on study design, the rationale behind inclusion or exclusion and the impact this had on internal and regulatory decisions. Data on 137 compounds (including 53 biologicals and 78 small molecules) from 259 studies showed wide variation in where, when and why recovery animals were included. An analysis of individual study and programme design shows that there are opportunities to reduce the use of recovery animals without impacting drug development. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Sewell, Fiona AU - Chapman, Kathryn AU - Baldrick, Paul AU - Brewster, David AU - Broadmeadow, Alan AU - Brown, Paul AU - Burns-Naas, Leigh Ann AU - Clarke, Janet AU - Constan, Alex AU - Couch, Jessica AU - Czupalla, Oliver AU - Danks, Andy AU - DeGeorge, Joseph AU - de Haan, Lolke AU - Hettinger, Klaudia AU - Hill, Marilyn AU - Festag, Matthias AU - Jacobs, Abby AU - Jacobson-Kram, David AU - Kopytek, Stephan AU - Lorenz, Helga AU - Moesgaard, Sophia Gry AU - Moore, Emma AU - Pasanen, Markku AU - Perry, Rick AU - Ragan, Ian AU - Robinson, Sally AU - Schmitt, Petra M AU - Short, Brian AU - Lima, Beatriz Silva AU - Smith, Diane AU - Sparrow, Sue AU - van Bekkum, Yvette AU - Jones, David AD - UK National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs), Gibbs Building, 215 Euston Road, London NW1 2BE, UK. Electronic address: fiona.sewell@nc3rs.org.uk. ; UK National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs), Gibbs Building, 215 Euston Road, London NW1 2BE, UK. ; Covance Laboratories Ltd, Otley Road, Harrogate HG3 1PY, UK. ; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02139, USA. ; Huntingdon Life Sciences Ltd, Occold, Eye, Suffolk IP23 7PX, UK. ; Food and Drug Administration (FDA), 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. ; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA. ; Biogen Idec, Cambridge, MA 02142, USA. ; Infinity Pharmaceuticals, 780 Memorial Drive, Cambridge, MA 02139, USA. ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. ; Bayer Pharma AG, Müllerstrasse 170, 13353 Berlin, Germany. ; Charles River Laboratories, Preclinical Services, Tranent, Edinburgh EH33 2NE, UK. ; Merck, 770 Sumneytown Pike, Mailstop WP45-201, West Point, PA 19486, USA. ; MedImmune, Granta Park, Cambridge CB21 6GH, UK. ; Austrian Agency for Health and Food Safety, Traisengasse 5, 1200 Vienna, Austria. ; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland. ; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, CH - 4070 Basel, Switzerland. ; Celgene, 86 Morris Avenue, Summit, NJ 07901, USA. ; AbbVie Deutschland GmbH & Co. KG, Knollstrasse, 67061 Ludwigshafen, Germany. ; Novo Nordisk A/S, Novo Nordisk Park, Maaloev, Denmark. ; Huntingdon Life Sciences Ltd, Alconbury, Huntingdon, Cambridgeshire PE28 4HS, UK. ; University of Eastern Finland, Faculty of Health Sciences, School of Pharmacy, Kuopio, Finland. ; Pfizer Drug Safety Research and Development, 455 Eastern Point Rd., Groton, CT 06340, USA. ; Board member, NC3Rs, Gibbs Building, 215 Euston Road, London NW1 2BE, UK. ; AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. ; Paul-Ehrlich-Institute, Federal Agency for Vaccines and Biomedicines, Langen, Germany. ; Allergan, Drug Safety Evaluation, 2525 Dupont Dr, RD-2A, Irvine, CA 92612-1599, USA. ; iMED, UL, University of Lisbon, Portugal. ; Millenium: The Takeda Oncology Company, 40 Landsdowne St., Cambridge, MA, USA. ; GlaxoSmithKline, Park Road, Ware, Hertfordshire SG12 0DP, UK. ; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium. ; Medicines Healthcare Products Regulatory Agency (MHRA), UK. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 413 EP - 429 VL - 70 IS - 1 KW - Index Medicus KW - Reversibility KW - Reduction KW - Regulatory toxicology KW - Non-clinical KW - Repeat-dose studies KW - Recovery KW - Dog KW - 3Rs KW - Rodent KW - Primate KW - Animals KW - International Cooperation KW - Humans KW - Surveys and Questionnaires KW - Time Factors KW - Research Design KW - Models, Animal KW - Toxicology -- methods KW - Drug Evaluation, Preclinical -- methods KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561974351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Recommendations+from+a+global+cross-company+data+sharing+initiative+on+the+incorporation+of+recovery+phase+animals+in+safety+assessment+studies+to+support+first-in-human+clinical+trials.&rft.au=Sewell%2C+Fiona%3BChapman%2C+Kathryn%3BBaldrick%2C+Paul%3BBrewster%2C+David%3BBroadmeadow%2C+Alan%3BBrown%2C+Paul%3BBurns-Naas%2C+Leigh+Ann%3BClarke%2C+Janet%3BConstan%2C+Alex%3BCouch%2C+Jessica%3BCzupalla%2C+Oliver%3BDanks%2C+Andy%3BDeGeorge%2C+Joseph%3Bde+Haan%2C+Lolke%3BHettinger%2C+Klaudia%3BHill%2C+Marilyn%3BFestag%2C+Matthias%3BJacobs%2C+Abby%3BJacobson-Kram%2C+David%3BKopytek%2C+Stephan%3BLorenz%2C+Helga%3BMoesgaard%2C+Sophia+Gry%3BMoore%2C+Emma%3BPasanen%2C+Markku%3BPerry%2C+Rick%3BRagan%2C+Ian%3BRobinson%2C+Sally%3BSchmitt%2C+Petra+M%3BShort%2C+Brian%3BLima%2C+Beatriz+Silva%3BSmith%2C+Diane%3BSparrow%2C+Sue%3Bvan+Bekkum%2C+Yvette%3BJones%2C+David&rft.aulast=Sewell&rft.aufirst=Fiona&rft.date=2014-10-01&rft.volume=70&rft.issue=1&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.07.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-15 N1 - Date created - 2014-09-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.07.018 ER - TY - JOUR T1 - More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems. AN - 1561973652; 25010377 AB - The clinical use of local anesthetic products to anesthetize mucous membranes has been associated with methemoglobinemia (MetHba), a serious condition in which the blood has reduced capacity to carry oxygen. An evaluation of spontaneous adverse event reporting of MetHba submitted to FDA through 2013 identified 375 reports associated with benzocaine and 16 reports associated with lidocaine. The current study was performed to determine the relative ability of benzocaine and lidocaine to produce methemoglobin (MetHb) in vitro. Incubation of 500μM benzocaine with whole human blood and pooled human liver S9 over 5h resulted in MetHb levels equaling 39.8±1.2% of the total hemoglobin. No MetHb formation was detected for 500μM lidocaine under the same conditions. Because liver S9 does not readily form lidocaine hydrolytic metabolites based on xylidine, a primary metabolic pathway, 500μM xylidine was directly incubated with whole blood and S9. Under these conditions MetHb levels of 4.4±0.4% were reached by 5h. Studies with recombinant cytochrome P450 revealed benzocaine to be extensively metabolized by CYP 1A2, with 2B6, 2C19, 2D6, and 2E1 also having activity. We conclude that benzocaine produces much more MetHb in in vitro systems than lidocaine or xylidine and that benzocaine should be more likely to cause MetHba in vivo as well. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Hartman, Neil R AU - Mao, Jinzhe J AU - Zhou, Hongfei AU - Boyne, Michael T AU - Wasserman, Adam M AU - Taylor, Kellie AU - Racoosin, Judith A AU - Patel, Vikram AU - Colatsky, Thomas AD - Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. Electronic address: neil.hartman@fda.hhs.gov. ; Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. ; Division of Pharmaceutical Analysis, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. ; Division of Anesthesia, Analgesia and Addiction Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. ; Division of Medication Error Prevention and Analysis, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 182 EP - 188 VL - 70 IS - 1 KW - Anesthetics, Local KW - 0 KW - Aniline Compounds KW - 2,6-xylidine KW - 4FT62OX08D KW - Methemoglobin KW - 9008-37-1 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Lidocaine KW - 98PI200987 KW - Benzocaine KW - U3RSY48JW5 KW - Index Medicus KW - Methemoglobinemia KW - Xylidine KW - Benzocaine hydroxylamine KW - Humans KW - Methemoglobin -- metabolism KW - In Vitro Techniques KW - Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Aniline Compounds -- metabolism KW - Lidocaine -- metabolism KW - Benzocaine -- metabolism KW - Methemoglobinemia -- chemically induced KW - Anesthetics, Local -- toxicity KW - Anesthetics, Local -- metabolism KW - Lidocaine -- toxicity KW - Benzocaine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561973652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=More+methemoglobin+is+produced+by+benzocaine+treatment+than+lidocaine+treatment+in+human+in+vitro+systems.&rft.au=Hartman%2C+Neil+R%3BMao%2C+Jinzhe+J%3BZhou%2C+Hongfei%3BBoyne%2C+Michael+T%3BWasserman%2C+Adam+M%3BTaylor%2C+Kellie%3BRacoosin%2C+Judith+A%3BPatel%2C+Vikram%3BColatsky%2C+Thomas&rft.aulast=Hartman&rft.aufirst=Neil&rft.date=2014-10-01&rft.volume=70&rft.issue=1&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.07.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-20 N1 - Date created - 2014-09-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.07.002 ER - TY - JOUR T1 - Public health decisions: actions and consequences. AN - 1561973523; 25092130 AB - The goal of public health is to promote the best possible health for the whole population. Public health issues are numerous and can be unbelievably complex in form, scope, and possible consequence. Most public health decisions involve assessing several different options, weighing the respective benefits and risks of those options, and making difficult decisions that hopefully provide the greatest benefit to the affected populations. Many risk management decisions involve a variety of societal factors which modify risk assessment choices. The purpose of this paper is to point out difficulties in making decisions that impact public health. The intent of such decisions is to improve public health, but as illustrated in the paper, there can be unintended adverse consequences. Such unplanned issues require continued attention and efforts for responsible officials in the protection of environmental public health. This article presents examples of such events, when in the past, it was necessary to assess and regulate a number of potentially hazardous chemicals commonly used as insecticides, gasoline additives, and wood preservatives. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Pohl, H R AU - Jones, D E AU - Holler, J S AU - Murray, H E AD - Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta GA, USA. Electronic address: hpohl@cdc.gov. ; Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta GA, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 363 EP - 369 VL - 70 IS - 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Insecticides KW - Wood preservatives KW - Risk management decisions KW - Chemical regulations KW - Gasoline additives KW - Humans KW - Risk Assessment -- methods KW - Decision Making KW - Risk Management -- methods KW - Public Health KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561973523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Public+health+decisions%3A+actions+and+consequences.&rft.au=Pohl%2C+H+R%3BJones%2C+D+E%3BHoller%2C+J+S%3BMurray%2C+H+E&rft.aulast=Pohl&rft.aufirst=H&rft.date=2014-10-01&rft.volume=70&rft.issue=1&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.07.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-15 N1 - Date created - 2014-09-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.07.023 ER - TY - JOUR T1 - New small-molecule inhibitors effectively blocking picornavirus replication. AN - 1561131239; 25008939 AB - Few drugs targeting picornaviruses are available, making the discovery of antivirals a high priority. Here, we identified and characterized three compounds from a library of kinase inhibitors that block replication of poliovirus, coxsackievirus B3, and encephalomyocarditis virus. Using an in vitro translation-replication system, we showed that these drugs inhibit different stages of the poliovirus life cycle. A4(1) inhibited both the formation and functioning of the replication complexes, while E5(1) and E7(2) were most effective during the formation but not the functioning step. Neither of the compounds significantly inhibited VPg uridylylation. Poliovirus resistant to E7(2) had a G5318A mutation in the 3A protein. This mutation was previously found to confer resistance to enviroxime-like compounds, which target a phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ)-dependent step in viral replication. Analysis of host protein recruitment showed that E7(2) reduced the amount of GBF1 on the replication complexes; however, the level of PI4KIIIβ remained intact. E7(2) as well as another enviroxime-like compound, GW5074, interfered with viral polyprotein processing affecting both 3C- and 2A-dependent cleavages, and the resistant G5318A mutation partially rescued this defect. Moreover, E7(2) induced abnormal recruitment to membranes of the viral proteins; thus, enviroxime-like compounds likely severely compromise the interaction of the viral polyprotein with membranes. A4(1) demonstrated partial protection from paralysis in a murine model of poliomyelitis. Multiple attempts to isolate resistant mutants in the presence of A4(1) or E5(1) were unsuccessful, showing that effective broad-spectrum antivirals could be developed on the basis of these compounds. Diverse picornaviruses can trigger multiple human maladies, yet currently, only hepatitis A virus and poliovirus can be controlled with vaccination. The development of antipicornavirus therapeutics is also facing significant difficulties because these viruses readily generate resistance to compounds targeting either viral or cellular factors. Here, we describe three novel compounds that effectively block replication of distantly related picornaviruses with minimal toxicity to cells. The compounds prevent viral RNA replication after the synthesis of the uridylylated VPg primer. Importantly, two of the inhibitors are strongly refractory to the emergence of resistant mutants, making them promising candidates for further broad-spectrum therapeutic development. Evaluation of one of the compounds in an in vivo model of poliomyelitis demonstrated partial protection from the onset of paralysis. Copyright © 2014, American Society for Microbiology. All Rights Reserved. JF - Journal of virology AU - Ford Siltz, Lauren A AU - Viktorova, Ekaterina G AU - Zhang, Ben AU - Kouiavskaia, Diana AU - Dragunsky, Eugenia AU - Chumakov, Konstantin AU - Isaacs, Lyle AU - Belov, George A AD - Department of Veterinary Medicine, University of Maryland, and Virginia-Maryland Regional College of Veterinary Medicine, College Park, Maryland, USA. ; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, USA. ; Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, USA. ; Department of Veterinary Medicine, University of Maryland, and Virginia-Maryland Regional College of Veterinary Medicine, College Park, Maryland, USA gbelov@umd.edu. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 11091 EP - 11107 VL - 88 IS - 19 KW - Antiviral Agents KW - 0 KW - Polyproteins KW - Small Molecule Libraries KW - Viral Proteins KW - 1-Phosphatidylinositol 4-Kinase KW - EC 2.7.1.67 KW - Index Medicus KW - Animals KW - Gene Expression Regulation, Viral KW - HeLa Cells KW - Humans KW - Disease Models, Animal KW - Mice KW - Polyproteins -- metabolism KW - Structure-Activity Relationship KW - 1-Phosphatidylinositol 4-Kinase -- genetics KW - Polyproteins -- antagonists & inhibitors KW - Encephalomyocarditis virus -- drug effects KW - 1-Phosphatidylinositol 4-Kinase -- metabolism KW - Enterovirus B, Human -- metabolism KW - Enterovirus B, Human -- genetics KW - Enterovirus B, Human -- drug effects KW - Polyproteins -- genetics KW - Mutation KW - 1-Phosphatidylinositol 4-Kinase -- antagonists & inhibitors KW - Signal Transduction KW - Cell-Free System KW - Encephalomyocarditis virus -- genetics KW - Encephalomyocarditis virus -- metabolism KW - Viral Proteins -- genetics KW - Poliomyelitis -- virology KW - Poliovirus -- growth & development KW - Small Molecule Libraries -- chemistry KW - Poliovirus -- drug effects KW - Virus Replication -- drug effects KW - Small Molecule Libraries -- pharmacology KW - Antiviral Agents -- chemistry KW - Antiviral Agents -- pharmacology KW - Poliovirus -- genetics KW - Viral Proteins -- metabolism KW - Viral Proteins -- antagonists & inhibitors KW - Poliomyelitis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561131239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=New+small-molecule+inhibitors+effectively+blocking+picornavirus+replication.&rft.au=Ford+Siltz%2C+Lauren+A%3BViktorova%2C+Ekaterina+G%3BZhang%2C+Ben%3BKouiavskaia%2C+Diana%3BDragunsky%2C+Eugenia%3BChumakov%2C+Konstantin%3BIsaacs%2C+Lyle%3BBelov%2C+George+A&rft.aulast=Ford+Siltz&rft.aufirst=Lauren&rft.date=2014-10-01&rft.volume=88&rft.issue=19&rft.spage=11091&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.01877-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-11 N1 - Date created - 2014-09-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Virol. 2004 Apr;78(7):3378-86 [15016860] J Virol. 2003 Dec;77(23):12679-91 [14610190] J Virol. 1968 Sep;2(9):859-64 [4302186] J Virol. 1975 Apr;15(4):1033-6 [163914] Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):951-5 [1846972] J Virol. 1992 Apr;66(4):1985-94 [1312615] Virology. 1992 Nov;191(1):166-75 [1329315] Arch Virol. 1994;139(3-4):351-63 [7832641] J Virol. 1995 Sep;69(9):5516-27 [7636997] J Virol. 1996 Jul;70(7):4854-7 [8676522] J Virol. 1997 Nov;71(11):8482-9 [9343205] J Virol. 1998 Aug;72(8):6456-64 [9658088] J Biol Chem. 1999 Mar 12;274(11):6992-7001 [10066753] Circulation. 2005 Feb 22;111(7):887-93 [15699250] Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5998-6003 [15837920] J Virol. 2005 Jun;79(11):7207-16 [15890959] Clin Microbiol Rev. 2006 Jan;19(1):80-94 [16418524] Dev Cell. 2006 Aug;11(2):191-201 [16890159] J Virol. 2007 Jan;81(2):558-67 [17079330] Cancer Cell. 2003 Dec;4(6):463-76 [14706338] Genes Dev. 2007 Jan 15;21(2):195-205 [17234885] J Virol. 2007 May;81(10):5238-45 [17329336] Antiviral Res. 2008 Sep;79(3):179-87 [18513807] PLoS Pathog. 2008 Nov;4(11):e1000216 [19023417] J Gen Virol. 2009 Aug;90(Pt 8):1869-79 [19439558] J Virol. 2009 Nov;83(22):11940-9 [19740986] J Virol. 2009 Nov;83(22):11665-72 [19740993] Cell. 2010 May 28;141(5):799-811 [20510927] J Gen Virol. 2010 Nov;91(Pt 11):2734-44 [20660150] Curr Top Microbiol Immunol. 2010;347:241-62 [20549474] BMJ. 2011;342:d35 [21292721] J Virol. 2011 Mar;85(5):2364-72 [21177810] J Virol. 2012 Jan;86(1):302-12 [22072780] Biochem Pharmacol. 2012 Jan 15;83(2):185-92 [21889497] EMBO J. 2012 Feb 1;31(3):754-66 [22124328] J Virol. 2012 Apr;86(7):3605-16 [22258260] Nat Chem. 2012 Jun;4(6):503-10 [22614387] Cell Res. 2012 Nov;22(11):1576-92 [22945356] J Virol. 2013 Apr;87(8):4252-60 [23365445] Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81 [23896472] J Virol. 2013 Oct;87(20):11031-46 [23926333] J Virol. 2014 Mar;88(5):2725-36 [24352456] J Virol. 1999 Dec;73(12):10104-12 [10559325] J Virol. 2000 Jul;74(14):6394-400 [10864650] Am J Med. 2002 Apr 22;112 Suppl 6A:42S-49S [11955459] J Virol. 2002 Nov;76(21):11113-22 [12368353] J Virol. 2003 Jan;77(1):45-56 [12477809] Arch Intern Med. 2003 Feb 24;163(4):487-94 [12588210] Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7289-94 [12754380] J Virol. 2003 Nov;77(21):11408-16 [14557626] J Med Chem. 2003 Nov 6;46(23):4910-25 [14584942] Cancer Res. 2004 Jul 1;64(13):4394-9 [15231645] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/JVI.01877-14 ER - TY - JOUR T1 - Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer. AN - 1561035527; 25097189 AB - The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is being considered as a potential therapeutic target for neuropsychiatric disorders. Previous studies suggested that this heteromer could be involved in the ability of D3R agonists to potentiate locomotor activation induced by D1R agonists. It has also been postulated that its overexpression plays a role in L-dopa-induced dyskinesia and in drug addiction. However, little is known about its biochemical properties. By combining bioluminescence resonance energy transfer, bimolecular complementation techniques, and cell-signaling experiments in transfected cells, evidence was obtained for a tetrameric stoichiometry of the D1R-D3R heteromer, constituted by two interacting D1R and D3R homodimers coupled to Gs and Gi proteins, respectively. Coactivation of both receptors led to the canonical negative interaction at the level of adenylyl cyclase signaling, to a strong recruitment of β-arrestin-1, and to a positive cross talk of D1R and D3R agonists at the level of mitogen-activated protein kinase (MAPK) signaling. Furthermore, D1R or D3R antagonists counteracted β-arrestin-1 recruitment and MAPK activation induced by D3R and D1R agonists, respectively (cross-antagonism). Positive cross talk and cross-antagonism at the MAPK level were counteracted by specific synthetic peptides with amino acid sequences corresponding to D1R transmembrane (TM) domains TM5 and TM6, which also selectively modified the quaternary structure of the D1R-D3R heteromer, as demonstrated by complementation of hemiproteins of yellow fluorescence protein fused to D1R and D3R. These results demonstrate functional selectivity of allosteric modulations within the D1R-D3R heteromer, which can be involved with the reported behavioral synergism of D1R and D3R agonists. U.S. Government work not protected by U.S. copyright. JF - Molecular pharmacology AU - Guitart, Xavier AU - Navarro, Gemma AU - Moreno, Estefania AU - Yano, Hideaki AU - Cai, Ning-Sheng AU - Sánchez-Soto, Marta AU - Kumar-Barodia, Sandeep AU - Naidu, Yamini T AU - Mallol, Josefa AU - Cortés, Antoni AU - Lluís, Carme AU - Canela, Enric I AU - Casadó, Vicent AU - McCormick, Peter J AU - Ferré, Sergi AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (X.G., H.Y., N.-S.C., M.S.-S., S.K.-B., Y.T.N., S.F.); Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (G.N., E.M., J.M., A.C., C.L., E.I.C., V.C., P.J.M.); and School of Pharmacy, University of East Anglia, Norwich, United Kingdom (P.J.M.). ; National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (X.G., H.Y., N.-S.C., M.S.-S., S.K.-B., Y.T.N., S.F.); Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (G.N., E.M., J.M., A.C., C.L., E.I.C., V.C., P.J.M.); and School of Pharmacy, University of East Anglia, Norwich, United Kingdom (P.J.M.) sferre@intra.nida.nih.gov. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 417 EP - 429 VL - 86 IS - 4 KW - ARRB1 protein, human KW - 0 KW - Arrestins KW - DRD1 protein, human KW - DRD3 protein, human KW - Dopamine Agonists KW - Receptors, Dopamine D1 KW - Receptors, Dopamine D3 KW - beta-Arrestin 1 KW - beta-Arrestins KW - GTP-Binding Protein alpha Subunits, Gi-Go KW - EC 3.6.5.1 KW - GTP-Binding Protein alpha Subunits, Gs KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - GTP-Binding Protein alpha Subunits, Gi-Go -- metabolism KW - MAP Kinase Signaling System KW - Dopamine Agonists -- pharmacology KW - Humans KW - HEK293 Cells KW - Adenylyl Cyclases -- metabolism KW - Allosteric Regulation KW - GTP-Binding Protein alpha Subunits, Gs -- metabolism KW - Protein Multimerization KW - Protein Binding KW - Arrestins -- metabolism KW - Receptors, Dopamine D3 -- agonists KW - Receptors, Dopamine D3 -- metabolism KW - Receptors, Dopamine D1 -- agonists KW - Receptors, Dopamine D1 -- chemistry KW - Receptors, Dopamine D3 -- chemistry KW - Allosteric Site KW - Receptors, Dopamine D1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561035527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Functional+selectivity+of+allosteric+interactions+within+G+protein-coupled+receptor+oligomers%3A+the+dopamine+D1-D3+receptor+heterotetramer.&rft.au=Guitart%2C+Xavier%3BNavarro%2C+Gemma%3BMoreno%2C+Estefania%3BYano%2C+Hideaki%3BCai%2C+Ning-Sheng%3BS%C3%A1nchez-Soto%2C+Marta%3BKumar-Barodia%2C+Sandeep%3BNaidu%2C+Yamini+T%3BMallol%2C+Josefa%3BCort%C3%A9s%2C+Antoni%3BLlu%C3%ADs%2C+Carme%3BCanela%2C+Enric+I%3BCasad%C3%B3%2C+Vicent%3BMcCormick%2C+Peter+J%3BFerr%C3%A9%2C+Sergi&rft.aulast=Guitart&rft.aufirst=Xavier&rft.date=2014-10-01&rft.volume=86&rft.issue=4&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=1521-0111&rft_id=info:doi/10.1124%2Fmol.114.093096 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-07 N1 - Date created - 2014-09-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Neurosci. 2002 Sep 15;22(18):7931-40 [12223546] J Neurosci. 2014 Mar 5;34(10):3545-58 [24599455] J Mol Biol. 2003 Jun 13;329(4):815-29 [12787680] J Biol Chem. 1996 Jul 5;271(27):16384-92 [8663163] J Neurosci. 1996 Oct 1;16(19):6100-6 [8815892] Mol Pharmacol. 1997 Sep;52(3):508-14 [9281614] Nat Rev Mol Cell Biol. 2006 Jun;7(6):449-56 [16625152] Pharmacol Ther. 2007 Dec;116(3):343-54 [17935788] Mol Pharmacol. 2008 Jul;74(1):59-69 [18424554] Nat Methods. 2008 Aug;5(8):727-33 [18587404] J Biol Chem. 2008 Sep 19;283(38):26016-25 [18644790] EMBO J. 2008 Sep 3;27(17):2293-304 [18668123] Neuropsychopharmacology. 2009 Mar;34(4):972-86 [18800071] Nat Chem Biol. 2009 Mar;5(3):131-4 [19219011] Br J Pharmacol. 2009 May;157(1):64-75 [19413572] Methods Mol Biol. 2009;574:215-34 [19685312] Dev Cell. 2009 Oct;17(4):443-58 [19853559] Curr Opin Pharmacol. 2010 Feb;10(1):87-92 [19837631] CNS Neurol Disord Drug Targets. 2010 Nov;9(5):596-600 [20632968] Biochem Biophys Res Commun. 2010 Nov 26;402(4):801-7 [21040702] Nat Med. 2010 Dec;16(12):1393-5 [21113156] Neuron. 2011 Jan 13;69(1):120-31 [21220103] PLoS One. 2011;6(1):e16088 [21264319] Nat Chem Biol. 2011 Sep;7(9):624-30 [21785426] Trends Pharmacol Sci. 2011 Sep;32(9):514-20 [21715028] Annu Rev Pharmacol Toxicol. 2012;52:179-97 [21942629] Mol Psychiatry. 2012 Jun;17(6):650-62 [21844870] Mol Pharmacol. 2013 Jul;84(1):158-69 [23632086] Pharmacol Rev. 2014;66(2):413-34 [24515647] J Biol Chem. 2003 Feb 14;278(7):4385-8 [12496294] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1124/mol.114.093096 ER - TY - JOUR T1 - Propentophylline increases striatal dopamine release but dampens methamphetamine-induced dopamine dynamics: A microdialysis study. AN - 1559617861; 25049173 AB - While there are currently no medications approved for methamphetamine (METH) addiction, it has been shown that propentofylline (PPF), an atypical methylxanthine, can suppress the rewarding effects of methamphetamine (METH) in mice. This experiment studied the interactions of PPF with METH in striatal dopaminergic transmission. Herein, the impact of PPF (10-40mM, intrastriatally perfused (80min) on the effect of METH (5mg/kg, i.p.) on striatal dopamine (DA) release was evaluated using brain microdialysis in Sprague-Dawley adult rats. METH was injected at the 60min time point of the 80min PPF perfusion. The extracellular levels of DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were determined using high performance liquid chromatography with electrochemical detection (HPLC-ED). PPF induced a concentration-dependent increase in DA release beginning 30min after the onset of PPF perfusion. DA peak levels evoked by 40mM PPF were similar to those induced by 5mg/kg METH i.p. Only the highest concentration of PPF decreased the METH-induced DA peak (circa 70%). The significant decreases in extracellular levels of DOPAC and HVA evoked by METH were partially blocked by 10 and 20mM PPF. Although 40mM of PPF also partially blocked the METH-induced DOPAC decrease, it completely blocked HVA depletion after a transient increase in HVA levels in METH-treated rats. Data indicates for the first time that while PPF increases presynaptic striatal DA dynamics it attenuates METH-induced striatal DA release and metabolism. Published by Elsevier Ltd. JF - Neurochemistry international AU - Gough, B AU - Pereira, F C AU - Fontes Ribeiro, C A AU - Ali, S F AU - Binienda, Z K AD - Div. of Neurotoxicology, NCTR/FDA, Jefferson, AR, USA. ; Farmacologia e Terapêutica Experimental/IBILI, Faculdade de Medicina da Univ. de Coimbra, Coimbra, Portugal. Electronic address: fredcp@ci.uc.pt. ; Farmacologia e Terapêutica Experimental/IBILI, Faculdade de Medicina da Univ. de Coimbra, Coimbra, Portugal. ; Div. of Neurotoxicology, NCTR/FDA, Jefferson, AR, USA. Electronic address: zbigniew.binienda@fda.hhs.gov. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 109 EP - 113 VL - 76 KW - Xanthines KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - propentofylline KW - 5RTA398U4H KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Propentofylline KW - Caudate nucleus KW - In vivo microdialysis KW - Rats KW - Microdialysis KW - Animals KW - Rats, Sprague-Dawley KW - Male KW - Chromatography, High Pressure Liquid KW - Corpus Striatum -- metabolism KW - Methamphetamine -- pharmacology KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Xanthines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1559617861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=Propentophylline+increases+striatal+dopamine+release+but+dampens+methamphetamine-induced+dopamine+dynamics%3A+A+microdialysis+study.&rft.au=Gough%2C+B%3BPereira%2C+F+C%3BFontes+Ribeiro%2C+C+A%3BAli%2C+S+F%3BBinienda%2C+Z+K&rft.aulast=Gough&rft.aufirst=B&rft.date=2014-10-01&rft.volume=76&rft.issue=&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=1872-9754&rft_id=info:doi/10.1016%2Fj.neuint.2014.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-15 N1 - Date created - 2014-09-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuint.2014.07.003 ER -