TY - CPAPER T1 - Insecticidal toxins from the spiders Diguetia canitics, Tegenaria agreslis, and Filistata hibernalis: Chemical characterization, molecular biology, biological activity, and potential uses in the development of new insecticides AN - 42293444; 3186480 AU - Kral, RM Jr AU - Krapcho, K J AU - Johnson, J AU - DelMar, E AU - VanWagenen, B C AU - Capuano, I V AU - Dunn, C K AU - Fuller, F H AU - Eppler, K G AU - Morgan, T K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 7500:Pharmacology KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42293444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Insecticidal+toxins+from+the+spiders+Diguetia+canitics%2C+Tegenaria+agreslis%2C+and+Filistata+hibernalis%3A+Chemical+characterization%2C+molecular+biology%2C+biological+activity%2C+and+potential+uses+in+the+development+of+new+insecticides&rft.au=Kral%2C+RM+Jr%3BKrapcho%2C+K+J%3BJohnson%2C+J%3BDelMar%2C+E%3BVanWagenen%2C+B+C%3BCapuano%2C+I+V%3BDunn%2C+C+K%3BFuller%2C+F+H%3BEppler%2C+K+G%3BMorgan%2C+T+K&rft.aulast=Kral&rft.aufirst=RM&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: USAMRID, Toxinology Division, Fort Detrick, MD 21702, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Shiga-like toxins of enterochemorrhagic E. coli AN - 42288764; 3186452 AU - O'Brien, AD Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 7500:Pharmacology KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42288764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Shiga-like+toxins+of+enterochemorrhagic+E.+coli&rft.au=O%27Brien%2C+AD&rft.aulast=O%27Brien&rft.aufirst=AD&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: USAMRID, Toxinology Division, Fort Detrick, MD 21702, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeting the calcium receptor as a novel therapeutic approach for hyperparathyroidism AN - 42211899; 3148589 AU - Nemeth, E F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42211899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Targeting+the+calcium+receptor+as+a+novel+therapeutic+approach+for+hyperparathyroidism&rft.au=Nemeth%2C+E+F&rft.aulast=Nemeth&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: British Endocrine Societies, 17/18 The Courtyard, Woodlands, Almondsbury, Bristol BS2 4NQ, UK. Phone: 01454 619036; Fax: 01454 616071; email: soc-endocristol.ac.uk, Price L26. ISSN 0022-0795. Paper No. S8 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use and interpretation of core samples to substantiate delineation of old-growth forests AN - 42164616; 3121746 AU - Blozan, W F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42164616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+and+interpretation+of+core+samples+to+substantiate+delineation+of+old-growth+forests&rft.au=Blozan%2C+W+F&rft.aulast=Blozan&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Institute of Biological Sciences, 730 11th St., NW, Washington, DC 20001-4521, Price $10. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of ramp (Allium tricoccum AiT.) harvesting in Great Smoky Mountains National Park AN - 42160820; 3120902 AU - Rock, J H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42160820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Impact+of+ramp+%28Allium+tricoccum+AiT.%29+harvesting+in+Great+Smoky+Mountains+National+Park&rft.au=Rock%2C+J+H&rft.aulast=Rock&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Institute of Biological Sciences, 730 11th St., NW, Washington, DC 20001-4521, Price $10. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacokinetic variability of terfenadine biotransformation in healthy volunteers AN - 42007159; 3083109 AU - Honig, P AU - Smith, J AU - Wortham, D AU - Zamani, K AU - Cantilena, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42007159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pharmacokinetic+variability+of+terfenadine+biotransformation+in+healthy+volunteers&rft.au=Honig%2C+P%3BSmith%2C+J%3BWortham%2C+D%3BZamani%2C+K%3BCantilena%2C+L&rft.aulast=Honig&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacolgy and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, USA. Poster Paper No. PI-61 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics AN - 42005761; 3083216 AU - Honig, P AU - Wortham, D AU - Hull, R AU - Zamani, K AU - Smith, J AU - Cantilena, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42005761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Itraconazole+affects+single-dose+terfenadine+pharmacokinetics+and+cardiac+repolarization+pharmacodynamics&rft.au=Honig%2C+P%3BWortham%2C+D%3BHull%2C+R%3BZamani%2C+K%3BSmith%2C+J%3BCantilena%2C+L&rft.aulast=Honig&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacolgy and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, USA. Poster Paper No. PII-49 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of esterase activity following low level exposure to cadmium AN - 41990785; 3086799 AU - Nix, D J AU - Yang, S K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41990785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inhibition+of+esterase+activity+following+low+level+exposure+to+cadmium&rft.au=Nix%2C+D+J%3BYang%2C+S+K&rft.aulast=Nix&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332, USA, Price $38.. Poster Paper No. 872 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a gaseous pollutant monitoring network for the national park service AN - 41987910; 3075520 AU - Flores, MI AU - Heavner, R L AU - Carson, B C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 5500:GEOSCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41987910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Development+of+a+gaseous+pollutant+monitoring+network+for+the+national+park+service&rft.au=Flores%2C+MI%3BHeavner%2C+R+L%3BCarson%2C+B+C&rft.aulast=Flores&rft.aufirst=MI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Environmenral Toxicology and Chemistry, 1010 North 12th Ave., Pensacola, FL 32501 Telephone:(904)469-1500, Abstracts. Price $30.. Poster Paper No. PD11 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spectral and polarimetric analysis of hyperspectral data collected by an acousto-optic tunable filter system AN - 41987547; 3085226 AU - Sturgeon, MA AU - Cheng, L-J AU - Durkee, P A AU - Hamilton, M K AU - Huth, J F AU - Mahoney, J C AU - Olsen, R C AU - Reyes, G F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41987547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Spectral+and+polarimetric+analysis+of+hyperspectral+data+collected+by+an+acousto-optic+tunable+filter+system&rft.au=Sturgeon%2C+MA%3BCheng%2C+L-J%3BDurkee%2C+P+A%3BHamilton%2C+M+K%3BHuth%2C+J+F%3BMahoney%2C+J+C%3BOlsen%2C+R+C%3BReyes%2C+G+F&rft.aulast=Sturgeon&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: SPIE, PO Box 10, Bellingham, WA 98227-0010, USA. Paper No. 2231-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitrogen deposition and possible effects on ecosystems in class 1 areas: Comparison of parks in the eastern and western U.S. AN - 41949854; 3075517 AU - Tonnessen, KA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 5500:GEOSCIENCE KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41949854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Synoptic+scale+variability+in+the+California+Current&rft.au=Mooers%2C+CNK%3BRobinson%2C+A+R%3BSmith%2C+JA%3BRienecker%2C+M+M&rft.aulast=Mooers&rft.aufirst=CNK&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Environmenral Toxicology and Chemistry, 1010 North 12th Ave., Pensacola, FL 32501 Telephone:(904)469-1500, Abstracts. Price $30.. Poster Paper No. PD08 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine-anti-cytokine antibody complexes can increase in vivo cytokine agonist effects AN - 41931900; 3048681 AU - Finkelman, F D AU - Madden, K B AU - Morris, S C AU - Holmes, J M AU - Katona, I M AU - Maliszewski, C R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41931900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytokine-anti-cytokine+antibody+complexes+can+increase+in+vivo+cytokine+agonist+effects&rft.au=Finkelman%2C+F+D%3BMadden%2C+K+B%3BMorris%2C+S+C%3BHolmes%2C+J+M%3BKatona%2C+I+M%3BMaliszewski%2C+C+R&rft.aulast=Finkelman&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 1010 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calcimimetics: Structurally and mechanistically novel compounds that inhibit hormone secretion from parathyroid cells AN - 41930971; 3046743 AU - Steffey, ME AU - Fox, J AU - VanWagenen, B C AU - Delmar, E G AU - Balandrin, M F AU - Nemeth, E F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41930971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Calcimimetics%3A+Structurally+and+mechanistically+novel+compounds+that+inhibit+hormone+secretion+from+parathyroid+cells&rft.au=Steffey%2C+ME%3BFox%2C+J%3BVanWagenen%2C+B+C%3BDelmar%2C+E+G%3BBalandrin%2C+M+F%3BNemeth%2C+E+F&rft.aulast=Steffey&rft.aufirst=ME&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc.1651 Third Avenue, New York, NY 10128, USA; Telephone: (212) 289-2300, Abstracts, Journal of Bone and Mineral Research, Volume 8 Supplement 1 August 1993, ISSN: 0884-0431 Poster Paper No. 236 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of interleukin-12 (IL-12) on an in vivo, T cell-dependent, humoral immune response AN - 41927635; 3047911 AU - Morris, S C AU - Hubbard, B AU - Gately, M AU - Gause, W C AU - Finkelman, F D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41927635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+interleukin-12+%28IL-12%29+on+an+in+vivo%2C+T+cell-dependent%2C+humoral+immune+response&rft.au=Morris%2C+S+C%3BHubbard%2C+B%3BGately%2C+M%3BGause%2C+W+C%3BFinkelman%2C+F+D&rft.aulast=Morris&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 240 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-5 induces S mu -S gamma 1 DNA rearrangement by B cells activated with dextran-linked anti-IgD antibodies and IL-4: A 3 signal model for Ig class switching AN - 41921985; 3048644 AU - Mandler, R AU - Chu, C C AU - Paul, W E AU - Max, EE AU - Snapper, C M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41921985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=IL-5+induces+S+mu+-S+gamma+1+DNA+rearrangement+by+B+cells+activated+with+dextran-linked+anti-IgD+antibodies+and+IL-4%3A+A+3+signal+model+for+Ig+class+switching&rft.au=Mandler%2C+R%3BChu%2C+C+C%3BPaul%2C+W+E%3BMax%2C+EE%3BSnapper%2C+C+M&rft.aulast=Mandler&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 973 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD28-B7/BB1 costimulatory pathway is normal in patients with systemic lupus erythematosus (SLE) AN - 41920330; 3048232 AU - Sfikakis, P P AU - Oglesby, R AU - Tsokos, G C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41920330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=CD28-B7%2FBB1+costimulatory+pathway+is+normal+in+patients+with+systemic+lupus+erythematosus+%28SLE%29&rft.au=Sfikakis%2C+P+P%3BOglesby%2C+R%3BTsokos%2C+G+C&rft.aulast=Sfikakis&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 561 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extracellular calcium-sensing mechanisms on osteoclasts and parathyroid cells are pharmacologically distinct AN - 41914020; 3047578 AU - Steffey, ME AU - Nemeth, E F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41914020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Extracellular+calcium-sensing+mechanisms+on+osteoclasts+and+parathyroid+cells+are+pharmacologically+distinct&rft.au=Steffey%2C+ME%3BNemeth%2C+E+F&rft.aulast=Steffey&rft.aufirst=ME&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc.1651 Third Avenue, New York, NY 10128, USA; Telephone: (212) 289-2300, Abstracts, Journal of Bone and Mineral Research, Volume 8 Supplement 1 August 1993, ISSN: 0884-0431 Poster Paper No. 1071 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dextran-linked anti-IgD antibodies inhibit T cell-mediated IgE production but augment the synthesis of IgM and IgG1 AN - 41913804; 3048005 AU - Pecanha, LMT AU - Yamaguchi, H AU - Lees, A AU - Noelle, R J AU - Mond, J J AU - Snapper, C M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41913804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dextran-linked+anti-IgD+antibodies+inhibit+T+cell-mediated+IgE+production+but+augment+the+synthesis+of+IgM+and+IgG1&rft.au=DeWitt%2C+L+M%3BMoore%2C+L&rft.aulast=DeWitt&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 334 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A first generation calcimimetic compound (NPS R-568) that acts on the parathyroid cell calcium receptor: A novel therapeutic approach for hyperparathyroidism AN - 41912819; 3046767 AU - Fox, J AU - Hadfield, S AU - Petty, BA AU - Nemeth, E F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41912819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=A+first+generation+calcimimetic+compound+%28NPS+R-568%29+that+acts+on+the+parathyroid+cell+calcium+receptor%3A+A+novel+therapeutic+approach+for+hyperparathyroidism&rft.au=Fox%2C+J%3BHadfield%2C+S%3BPetty%2C+BA%3BNemeth%2C+E+F&rft.aulast=Fox&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc.1651 Third Avenue, New York, NY 10128, USA; Telephone: (212) 289-2300, Abstracts, Journal of Bone and Mineral Research, Volume 8 Supplement 1 August 1993, ISSN: 0884-0431 Poster Paper No. 260 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine regulation of intestinal mastocytosis in mice infected with Nippostrongylus Brasiliensis AN - 41912731; 3048027 AU - Madden, K B AU - Urban, JF Jr AU - Finkelman, F D AU - Gause, W C AU - Katona, I M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41912731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytokine+regulation+of+intestinal+mastocytosis+in+mice+infected+with+Nippostrongylus+Brasiliensis&rft.au=Madden%2C+K+B%3BUrban%2C+JF+Jr%3BFinkelman%2C+F+D%3BGause%2C+W+C%3BKatona%2C+I+M&rft.aulast=Madden&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 356 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of action of the calcimimetic compounds NPS R-467 and NPS R-568 in xenopus oocytes expressing a bovine parathyroid cell calcium receptor AN - 41904919; 3046573 AU - Hammerland, L G AU - Brown, E M AU - Hebert, S C AU - Nemeth, E F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41904919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mechanism+of+action+of+the+calcimimetic+compounds+NPS+R-467+and+NPS+R-568+in+xenopus+oocytes+expressing+a+bovine+parathyroid+cell+calcium+receptor&rft.au=Hammerland%2C+L+G%3BBrown%2C+E+M%3BHebert%2C+S+C%3BNemeth%2C+E+F&rft.aulast=Hammerland&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc.1651 Third Avenue, New York, NY 10128, USA; Telephone: (212) 289-2300, Abstracts, Journal of Bone and Mineral Research, Volume 8 Supplement 1 August 1993, ISSN: 0884-0431 Paper No. 65 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The calcimimetic compound NPS467 reduces plasma calcium in a dose-dependent and stereo-specific manner AN - 41904722; 3046761 AU - Rogers, K V AU - Fox, J AU - Nemeth, E F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41904722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=The+calcimimetic+compound+NPS467+reduces+plasma+calcium+in+a+dose-dependent+and+stereo-specific+manner&rft.au=Rogers%2C+K+V%3BFox%2C+J%3BNemeth%2C+E+F&rft.aulast=Rogers&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc.1651 Third Avenue, New York, NY 10128, USA; Telephone: (212) 289-2300, Abstracts, Journal of Bone and Mineral Research, Volume 8 Supplement 1 August 1993, ISSN: 0884-0431 Poster Paper No. 254 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TGF- beta -1 selectively stimulates IgG2b secretion by LPS-activated murine B cells AN - 41901745; 3048720 AU - McIntyre, T M AU - Klinman AU - Rothman, P AU - Lugo, M AU - Dasch, J R AU - Mond, J J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41901745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=TGF-+beta+-1+selectively+stimulates+IgG2b+secretion+by+LPS-activated+murine+B+cells&rft.au=McIntyre%2C+T+M%3BKlinman%3BRothman%2C+P%3BLugo%2C+M%3BDasch%2C+J+R%3BMond%2C+J+J&rft.aulast=McIntyre&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 1049 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning and expression of a G-protein-coupled calcium receptor from a human parathyroid adenoma AN - 41898909; 3046633 AU - Garrett, JE AU - Hung, B C AU - Brown, E M AU - Hebert, S C AU - Fuller, F AU - Nemeth, E F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloning+and+expression+of+a+G-protein-coupled+calcium+receptor+from+a+human+parathyroid+adenoma&rft.au=Garrett%2C+JE%3BHung%2C+B+C%3BBrown%2C+E+M%3BHebert%2C+S+C%3BFuller%2C+F%3BNemeth%2C+E+F&rft.aulast=Garrett&rft.aufirst=JE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc.1651 Third Avenue, New York, NY 10128, USA; Telephone: (212) 289-2300, Abstracts, Journal of Bone and Mineral Research, Volume 8 Supplement 1 August 1993, ISSN: 0884-0431 Paper No. 125 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of LPS-induced macrophage gene expression by SDZ 880.431 and R. sphaeroides lipid A AN - 41838053; 2855250 AU - Manthey, CL AU - Perera, P-Y AU - Stuetz, P L AU - Qureshi, N AU - Hamilton, T A AU - Vogel, S N Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inhibition+of+LPS-induced+macrophage+gene+expression+by+SDZ+880.431+and+R.+sphaeroides+lipid+A&rft.au=Manthey%2C+CL%3BPerera%2C+P-Y%3BStuetz%2C+P+L%3BQureshi%2C+N%3BHamilton%2C+T+A%3BVogel%2C+S+N&rft.aulast=Manthey&rft.aufirst=CL&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Dues and Subscriptions Services, FASEB, 9650 Rockville Pike, Bethesda, MD 20814-3998, USA; Telephone: (301) 530-7027, Paper No. 202 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quinolinic acid (QA) levels in the cerebrospinal fluid (CSF) of patients with systemic lupus erythematosus (SLE): Pathogenetic and clinical significance AN - 41835738; 2832115 AU - Vogelgesang, S AU - Heyes, M P AU - Salazar, A M AU - Sfikakis, P P AU - Lipnick, R N AU - Klipple, G L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41835738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Quinolinic+acid+%28QA%29+levels+in+the+cerebrospinal+fluid+%28CSF%29+of+patients+with+systemic+lupus+erythematosus+%28SLE%29%3A+Pathogenetic+and+clinical+significance&rft.au=Vogelgesang%2C+S%3BHeyes%2C+M+P%3BSalazar%2C+A+M%3BSfikakis%2C+P+P%3BLipnick%2C+R+N%3BKlipple%2C+G+L&rft.aulast=Vogelgesang&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ACR, Paper No. 155 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elevated serum levels of soluble intercellular adhesion molecule 1 (ICAM-1) in patients with systemic sclerosis (SS) AN - 41831415; 2842959 AU - Sfikakis, P P AU - Tesar, J AU - Lipnick, R N AU - Amstrong, J AU - Klipple, G L AU - Tsokos, G C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41831415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Elevated+serum+levels+of+soluble+intercellular+adhesion+molecule+1+%28ICAM-1%29+in+patients+with+systemic+sclerosis+%28SS%29&rft.au=Sfikakis%2C+P+P%3BTesar%2C+J%3BLipnick%2C+R+N%3BAmstrong%2C+J%3BKlipple%2C+G+L%3BTsokos%2C+G+C&rft.aulast=Sfikakis&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ACR, Paper No. D141 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation of in vivo mutated T cell clones from the peripheral blood of patients with systemic sclerosis (SS) AN - 41813214; 2830238 AU - Sfikakis, P P AU - Tesar, J AU - Theocharis, S AU - Douvas, A AU - Lipnick, R N AU - Klipple, G L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41813214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Isolation+of+in+vivo+mutated+T+cell+clones+from+the+peripheral+blood+of+patients+with+systemic+sclerosis+%28SS%29&rft.au=Sfikakis%2C+P+P%3BTesar%2C+J%3BTheocharis%2C+S%3BDouvas%2C+A%3BLipnick%2C+R+N%3BKlipple%2C+G+L&rft.aulast=Sfikakis&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ACR, Paper No. 21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T cell antigen UM4D4 (CDw60) is present on lung and skin fibroblasts and fibroblast-like synoviocytes AN - 41811939; 2831007 AU - Winn, B E AU - DesRosier, K F AU - Dixon, P S AU - Hensley, R AU - Derdak, S AU - Higgs, J B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41811939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=T+cell+antigen+UM4D4+%28CDw60%29+is+present+on+lung+and+skin+fibroblasts+and+fibroblast-like+synoviocytes&rft.au=Winn%2C+B+E%3BDesRosier%2C+K+F%3BDixon%2C+P+S%3BHensley%2C+R%3BDerdak%2C+S%3BHiggs%2C+J+B&rft.aulast=Winn&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ACR, Paper No. PO308 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three-dimensional visualization by laser scanning functional redox confocal microscopy: The dynamic corneal epithelium AN - 41807632; 2801571 AU - Masters, B R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41807632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Three-dimensional+visualization+by+laser+scanning+functional+redox+confocal+microscopy%3A+The+dynamic+corneal+epithelium&rft.au=Masters%2C+B+R&rft.aulast=Masters&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FAMS, P.O. Box 832, Mahwah, NJ 07430, USA; Telephone: (201) 818-1010; Fax: (201) 818-0086, Proceedings, Scanning - The Journal of Scanning Microscopy, ISSN: 0161-0457, Vol. 14, Supplement II (1992), $25.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Historical perspective on confocal microscopy AN - 41766783; 2801964 AU - Masters, B R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41766783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Historical+perspective+on+confocal+microscopy&rft.au=Masters%2C+B+R&rft.aulast=Masters&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FAMS, P.O. Box 832, Mahwah, NJ 07430, USA; Telephone: (201) 818-1010; Fax: (201) 818-0086, Proceedings, Scanning - The Journal of Scanning Microscopy, ISSN: 0161-0457, Vol. 14, Supplement II (1992), $25.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine gene expression during a primary in vivo immune response AN - 41614247; 2455920 AU - Svetic, A AU - Finkelman, F D AU - Dieffenbach, C W AU - Scott, DE AU - Steinberg, AD AU - Gause, W C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41614247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytokine+gene+expression+during+a+primary+in+vivo+immune+response&rft.au=Svetic%2C+A%3BFinkelman%2C+F+D%3BDieffenbach%2C+C+W%3BScott%2C+DE%3BSteinberg%2C+AD%3BGause%2C+W+C&rft.aulast=Svetic&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15F, 1991; ISSN: 0730-2312 Poster Paper No. P 259 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine regulation of immunoglobulin isotype selection in vivo AN - 41606873; 2455259 AU - Finkelman, F D AU - Urban, J F AU - Svetic, A AU - Gause, W Jr AU - Gresser, I AU - Holmes, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41606873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytokine+regulation+of+immunoglobulin+isotype+selection+in+vivo&rft.au=Finkelman%2C+F+D%3BUrban%2C+J+F%3BSvetic%2C+A%3BGause%2C+W+Jr%3BGresser%2C+I%3BHolmes%2C+J+M&rft.aulast=Finkelman&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15F, 1991; ISSN: 0730-2312 Paper No. P 007 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nephrotoxicity of aminoglycosides in rats is associated with stimulation of the renal endoplasmic reticulum calcium pump AN - 41595856; 2431976 AU - DeWitt, L M AU - Moore, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41595856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Nephrotoxicity+of+aminoglycosides+in+rats+is+associated+with+stimulation+of+the+renal+endoplasmic+reticulum+calcium+pump&rft.au=DeWitt%2C+L+M%3BMoore%2C+L&rft.aulast=DeWitt&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th Street, NW, Suite 1100, Washington, DC 20005, USA. Telephone: (202) 371-1393. Fax: (202) 371-1090., Poster Paper No. 492 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Indiana Dunes - a park fifty years too late? AN - 41592327; 2481199 AU - Engquist, D B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5500:GEOSCIENCE KW - U 2000:BIOLOGY GENERAL KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41592327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Indiana+Dunes+-+a+park+fifty+years+too+late%3F&rft.au=Engquist%2C+D+B&rft.aulast=Engquist&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Wetland Scientists, P.O. Box 296, Wilmington, NC 28402, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemical hypoxia induces MAPK activation in renal epithelial cells AN - 41576509; 3438787 AU - Sidhu, G S AU - Goyal, N AU - Maheshwari, R K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41576509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chemical+hypoxia+induces+MAPK+activation+in+renal+epithelial+cells&rft.au=Sidhu%2C+G+S%3BGoyal%2C+N%3BMaheshwari%2C+R+K&rft.aulast=Sidhu&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 1338 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions between beta-amyloid and acetylcholine in the development of Alzheimer's disease AN - 41567760; 3445236 AU - Ehrenstein, G AU - Galdzicki, Z AU - Lange, G D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41567760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interactions+between+beta-amyloid+and+acetylcholine+in+the+development+of+Alzheimer%27s+disease&rft.au=Ehrenstein%2C+G%3BGaldzicki%2C+Z%3BLange%2C+G+D&rft.aulast=Ehrenstein&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Biophysical Society, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7114; fax: (301) 530-7133; email: society@biophysics.faseb.org; URL: www.biophysics.faseb.org, Abstracts available. Price $25. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of neutral endoprotease (NEP) inhibitor thiorphan on hemodynamics and renal excretory function in four models of experimental hypertension (HT) in rats AN - 41559849; 2369402 AU - Pamnani, M B AU - Ghai, R D AU - Yuan, C AU - Chen, S AU - Bryant, HJ AU - Schooley, J F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41559849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+neutral+endoprotease+%28NEP%29+inhibitor+thiorphan+on+hemodynamics+and+renal+excretory+function+in+four+models+of+experimental+hypertension+%28HT%29+in+rats&rft.au=Pamnani%2C+M+B%3BGhai%2C+R+D%3BYuan%2C+C%3BChen%2C+S%3BBryant%2C+HJ%3BSchooley%2C+J+F&rft.aulast=Pamnani&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: APS Subscription, 9650 Rockville Pike, Bethesda, MD 20814, USA, The Physiologist, ISSN: 0031-9376, Vol 33, No 4, August 1990, abstracts: $25.00 & single issue $5.00; subscription: $25.00/yr in US & $35.00 elsewhere Paper No. 28.10 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Better model of experimental hypertension (HT) associated with streptozotocin (STZ) induced insulin dependent diabetes mellitus (IDDM) AN - 41552240; 2369406 AU - Chen, S AU - Yuan, C AU - Schooley, J F AU - Haddy, F J AU - Pamnani, M B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41552240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Better+model+of+experimental+hypertension+%28HT%29+associated+with+streptozotocin+%28STZ%29+induced+insulin+dependent+diabetes+mellitus+%28IDDM%29&rft.au=Chen%2C+S%3BYuan%2C+C%3BSchooley%2C+J+F%3BHaddy%2C+F+J%3BPamnani%2C+M+B&rft.aulast=Chen&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: APS Subscription, 9650 Rockville Pike, Bethesda, MD 20814, USA, The Physiologist, ISSN: 0031-9376, Vol 33, No 4, August 1990, abstracts: $25.00 & single issue $5.00; subscription: $25.00/yr in US & $35.00 elsewhere Paper No. 28.12 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential expression of IGF-I, IGF-II and IGF-IR in various organs following hypoxia and picroliv treatment AN - 41552004; 3438115 AU - Gaddipati, J P AU - Banaudha, K K AU - Mani, H AU - Sharma, S K AU - Kulshreshtha, D K AU - Maheshwari, R K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41552004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Either+B7-1+or+B7-2+interactions+can+provide+the+essential+B7+costimulatory+signals+for+an+in+vivo+mucosal+Th2-like+response&rft.au=Gause%2C+W+C%3BLu%2C+P%3BZhou%2C+X+D%3BChen%2C+S+J%3BFinkelman%2C+F+D%3BUrban%2C+JJ+Jr&rft.aulast=Gause&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 666 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Picroliv prevents cell death during hepatocellular remodeling following ischemia-reperfusion injury AN - 41549917; 3440276 AU - Singh, A K AU - Mani, H AU - Banaudha, K K AU - Kulshreshtha, D K AU - Sharma, S K AU - Maheshwari, R K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41549917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Picroliv+prevents+cell+death+during+hepatocellular+remodeling+following+ischemia-reperfusion+injury&rft.au=Singh%2C+A+K%3BMani%2C+H%3BBanaudha%2C+K+K%3BKulshreshtha%2C+D+K%3BSharma%2C+S+K%3BMaheshwari%2C+R+K&rft.aulast=Singh&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 2827 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Curcumin differentially regulates TGF-b and TGF-b receptor in cutaneous wound healing AN - 41520790; 3438817 AU - Mani, H AU - Sidhu, G S AU - Banaudha, K K AU - Maheshwari, R K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41520790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Curcumin+differentially+regulates+TGF-b+and+TGF-b+receptor+in+cutaneous+wound+healing&rft.au=Mani%2C+H%3BSidhu%2C+G+S%3BBanaudha%2C+K+K%3BMaheshwari%2C+R+K&rft.aulast=Mani&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 1368 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calcitonin gene related peptide produces marked vasodilation in the canine forelimb perfused at natural flow AN - 41511939; 2372729 AU - Dobbins, DE AU - Dabney, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41511939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Calcitonin+gene+related+peptide+produces+marked+vasodilation+in+the+canine+forelimb+perfused+at+natural+flow&rft.au=Dobbins%2C+DE%3BDabney%2C+J+M&rft.aulast=Dobbins&rft.aufirst=DE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: APS Subscription, 9650 Rockville Pike, Bethesda, MD 20814, USA, The Physiologist, ISSN: 0031-9376, Vol 33, No 4, August 1990, abstracts: $25.00 & single issue $5.00; subscription: $25.00/yr in US & $35.00 elsewhere Paper No. 64.2 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular pathogenesis of lung cancer AN - 41504755; 2361404 AU - Minna, J AU - D'Amico, D AU - Broers, J AU - Buchhagen, D AU - Carbone, D AU - Chiba, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41504755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+pathogenesis+of+lung+cancer&rft.au=Minna%2C+J%3BD%27Amico%2C+D%3BBroers%2C+J%3BBuchhagen%2C+D%3BCarbone%2C+D%3BChiba%2C+I&rft.aulast=Minna&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Taylor & Francis Ltd., 4 John St., London WC1N 2ET, UK or 1900 Frost Rd., Suite 101, Bristol, PA 19007, USA, Abstracts, Clinical and Experimental Metastasis, Vol. 8, 1990, Supplement No. 1, ISSN: 0262-0898 Paper No. 3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of cellular gene rrg is associated with the reversion of ras -transformed NIH 3T3 by interferon AN - 41438469; 2259049 AU - Contente, S AU - Kenyon, K AU - Friedman, R M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41438469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expression+of+cellular+gene+rrg+is+associated+with+the+reversion+of+ras+-transformed+NIH+3T3+by+interferon&rft.au=Contente%2C+S%3BKenyon%2C+K%3BFriedman%2C+R+M&rft.aulast=Contente&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Paper No. 5525 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of glutathione in acetaminophen induced potentiation of 1,1-dichloroethylene toxicity AN - 41424705; 2190272 AU - Wright, P B AU - Moore, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41424705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+glutathione+in+acetaminophen+induced+potentiation+of+1%2C1-dichloroethylene+toxicity&rft.au=Wright%2C+P+B%3BMoore%2C+L&rft.aulast=Wright&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th St., NW, Ste. 1100, Washington, DC 20005, USA. Telephone: 202-293-5935. Fax: 202-371-1090., Poster Paper No. 1178 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD23 has little role in the generation of an in vivo polyclonal IgE response in mice AN - 41416180; 2126856 AU - Katona, I M AU - Urban, JF Jr AU - Conrad, D H AU - Finkelman, F D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41416180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=CD23+has+little+role+in+the+generation+of+an+in+vivo+polyclonal+IgE+response+in+mice&rft.au=Katona%2C+I+M%3BUrban%2C+JF+Jr%3BConrad%2C+D+H%3BFinkelman%2C+F+D&rft.aulast=Katona&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequence and developmental regulation of Xenopus laevis serum albumins-members of the albumin, alpha -fetoprotein, vitamin D-binding protein multigene family AN - 41400114; 2074931 AU - Moskaitis, JE AU - Sargent, T D AU - Haefliger, D N AU - Wahli, W AU - Schoenberg Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41400114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sequence+and+developmental+regulation+of+Xenopus+laevis+serum+albumins-members+of+the+albumin%2C+alpha+-fetoprotein%2C+vitamin+D-binding+protein+multigene+family&rft.au=Moskaitis%2C+JE%3BSargent%2C+T+D%3BHaefliger%2C+D+N%3BWahli%2C+W%3BSchoenberg&rft.aulast=Moskaitis&rft.aufirst=JE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Secondary structure of the herpes simplex virus type-1 major DNA-binding protein by raman spectroscopy AN - 41391693; 2059441 AU - Ruyechan, W T AU - Williams, R W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41391693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Secondary+structure+of+the+herpes+simplex+virus+type-1+major+DNA-binding+protein+by+raman+spectroscopy&rft.au=Ruyechan%2C+W+T%3BWilliams%2C+R+W&rft.aulast=Ruyechan&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasma concentration-response relationship in the rat of NPS 1506, a novel NMDA receptor antagonist for the treatment of stroke AN - 41385399; 3350039 AU - Wells, D S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 1500:Biochemistry KW - U 7500:Pharmacology KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41385399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Plasma+concentration-response+relationship+in+the+rat+of+NPS+1506%2C+a+novel+NMDA+receptor+antagonist+for+the+treatment+of+stroke&rft.au=Wells%2C+D+S&rft.aulast=Wells&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Society for the Study of Xenobiotics, P.O. Box 3, Cabin John, MD 20818. Poster Paper No. 71 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of interleukin-2 receptors by endotoxin in human natural killer cells AN - 41381262; 2048478 AU - Kang, Y H AU - Katona, I M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41381262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+interleukin-2+receptors+by+endotoxin+in+human+natural+killer+cells&rft.au=Kang%2C+Y+H%3BKatona%2C+I+M&rft.aulast=Kang&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estrogen-regulated posttranscriptional suppression of Xenopus laevis serum albumin mRNA AN - 41368660; 2049633 AU - Schoenberg AU - Smith, L H AU - Moskaitis, JE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41368660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Estrogen-regulated+posttranscriptional+suppression+of+Xenopus+laevis+serum+albumin+mRNA&rft.au=Schoenberg%3BSmith%2C+L+H%3BMoskaitis%2C+JE&rft.aulast=Schoenberg&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of numatrin, the nuclear matrix protein associated with induction of mitogenesis, as the nucleolar protein B23. Implication for the role of the nucleolus in early transduction of mitogenic signals AN - 41359326; 2055604 AU - Feurstein, N AU - Chan, P-K AU - Mond, J J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41359326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Leukotrienes+Produce+Coronary+Constriction+in+the+Intact+Pig+Heart&rft.au=Boyd%2C+L%3BEzra%2C+D%3BFeuerstein%2C+G%3BGoldstein%2C+R&rft.aulast=Boyd&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Automatic motion detection in Rhesus monkeys AN - 41357723; 2000161 AU - Shires, J AU - Fiala, N AU - Dubois, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41357723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Automatic+motion+detection+in+Rhesus+monkeys&rft.au=Shires%2C+J%3BFiala%2C+N%3BDubois%2C+A&rft.aulast=Shires&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08854 (USA), IEEE Catalog NO.: 88CH2566-8. Library of Congress Catalog Card No.: 88-80177. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biological control in National Park Service - Government perspective AN - 41350005; 3347365 AU - Johnston, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41350005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expression+of+cellular+gene+rrg+is+associated+with+the+reversion+of+ras+-transformed+NIH+3T3+by+interferon&rft.au=Contente%2C+S%3BKenyon%2C+K%3BFriedman%2C+R+M&rft.aulast=Contente&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Entomological Society of America, 9301 Annapolis Road, Lanham, MD 20706-3115, Contact individual authors directly, or search abstracts at http://www.sheridan.com/entsoc/abs N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Earthworm burrowing and effects on soil structure and transmissivity AN - 41348581; 1982181 AU - Kemper, W D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41348581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Earthworm+burrowing+and+effects+on+soil+structure+and+transmissivity&rft.au=Kemper%2C+W+D&rft.aulast=Kemper&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASA, 677 South Segoe Road, Madison, WI 53711 (USA). Telephone: (608)-273-8080. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of asymmetric structure on the intensification of tropical cyclones AN - 41332742; 3317394 AU - Jeng, Bao-Fong AU - Peng AU - Williams, R T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41332742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Combat+stresses+of+chemical+and+biological+warfare&rft.au=Fullerton%2C+C+S%3BUrsano%2C+R+J&rft.aulast=Fullerton&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Meteorological Society, 45 Beacon Street, Boston, MA 02108-3693, Selected full papers available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of mesoscale convective vortices in determining the circulation structure during tropical cyclone formation AN - 41332610; 3317427 AU - Harr, P A AU - Finta, CA AU - Elsberry, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41332610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+mesoscale+convective+vortices+in+determining+the+circulation+structure+during+tropical+cyclone+formation&rft.au=Harr%2C+P+A%3BFinta%2C+CA%3BElsberry%2C+R+L&rft.aulast=Harr&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Meteorological Society, 45 Beacon Street, Boston, MA 02108-3693, Selected full papers available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Boundary layer evolution in response to variations of sea surface temperature and wind shear AN - 41324329; 3323268 AU - Wang, Qing AU - Pan, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5500:Geoscience KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41324329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Boundary+layer+evolution+in+response+to+variations+of+sea+surface+temperature+and+wind+shear&rft.au=Wang%2C+Qing%3BPan%2C+L&rft.aulast=Wang&rft.aufirst=Qing&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Meteorological Society, 45 Beacon Street, Boston, MA 02108-3693, Selected abstracts available. Price $60. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preadolescent peer relatedness and health AN - 41312868; 1941700 AU - Fullerton, C S AU - Ursano, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41312868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Preadolescent+peer+relatedness+and+health&rft.au=Fullerton%2C+C+S%3BUrsano%2C+R+J&rft.aulast=Fullerton&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Office of Internationals Affairs, APA, 1400 K Street NW, Washington, DC 20005 (USA). Telephone: 202 682 6286. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extratropical transition of western north Pacific tropical cyclones AN - 41311515; 3317527 AU - Klein, P M AU - Harr, P A AU - Elsberry, R L AU - Hogan, T F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41311515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Extratropical+transition+of+western+north+Pacific+tropical+cyclones&rft.au=Klein%2C+P+M%3BHarr%2C+P+A%3BElsberry%2C+R+L%3BHogan%2C+T+F&rft.aulast=Klein&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Meteorological Society, 45 Beacon Street, Boston, MA 02108-3693, Selected full papers available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unbalanced frontogenesis with constant potential vorticity AN - 41303836; 3317045 AU - Williams, R T AU - Neves, APC AU - Peng AU - Blumen, W C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5700:Marine Science KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41303836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Unbalanced+frontogenesis+with+constant+potential+vorticity&rft.au=Williams%2C+R+T%3BNeves%2C+APC%3BPeng%3BBlumen%2C+W+C&rft.aulast=Williams&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Meteorological Society, 45 Beacon Street, Boston, MA 02108-3693, Selected full papers available. Price $60. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurobehavioral consequences of HIV infection AN - 41302187; 1940867 AU - Salazar, A M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41302187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neurobehavioral+consequences+of+HIV+infection&rft.au=Salazar%2C+A+M&rft.aulast=Salazar&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Office of Internationals Affairs, APA, 1400 K Street NW, Washington, DC 20005 (USA). Telephone: 202 682 6286. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combat stresses of chemical and biological warfare AN - 41294479; 1940694 AU - Fullerton, C S AU - Ursano, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41294479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Combat+stresses+of+chemical+and+biological+warfare&rft.au=Fullerton%2C+C+S%3BUrsano%2C+R+J&rft.aulast=Fullerton&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Office of Internationals Affairs, APA, 1400 K Street NW, Washington, DC 20005 (USA). Telephone: 202 682 6286. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Systematic approach to tropical cyclone track forecasting: Scenario-specific model and objective guidance traits AN - 41289406; 3317577 AU - Carr, LE III AU - Elsberry, R L AU - Boothe, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41289406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Systematic+approach+to+tropical+cyclone+track+forecasting%3A+Scenario-specific+model+and+objective+guidance+traits&rft.au=Carr%2C+LE+III%3BElsberry%2C+R+L%3BBoothe%2C+MA&rft.aulast=Carr&rft.aufirst=LE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Meteorological Society, 45 Beacon Street, Boston, MA 02108-3693, Selected full papers available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Circulation and thermal structure in the South China Sea AN - 41283490; 3295256 AU - Ehret, L L AU - Chu, P AU - Edmons, N L AU - Hsing-Chia, Tseng Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41283490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Circulation+and+thermal+structure+in+the+South+China+Sea&rft.au=Ehret%2C+L+L%3BChu%2C+P%3BEdmons%2C+N+L%3BHsing-Chia%2C+Tseng&rft.aulast=Ehret&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Geophysical Union, 2000 Florida Avenue, NW, Washington, DC 20009, Abstracts available. Price $25. Poster Paper No. OP32A-9 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cardiovascular fitness and exercise tolerance in panic disorder patients AN - 41260988; 3289379 AU - Lerew AU - Schmidt, N B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41260988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cardiovascular+fitness+and+exercise+tolerance+in+panic+disorder+patients&rft.au=Lerew%3BSchmidt%2C+N+B&rft.aulast=Lerew&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association for the Advancement of Behavior Therapy, 305 7th Avenue, New York, NY 10001-6008, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dichotomous thinking among restrained eaters: Is it domain specific? AN - 41250972; 3289494 AU - Hodges, S AU - Sbrocco, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41250972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dichotomous+thinking+among+restrained+eaters%3A+Is+it+domain+specific%3F&rft.au=Hodges%2C+S%3BSbrocco%2C+T&rft.aulast=Hodges&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association for the Advancement of Behavior Therapy, 305 7th Avenue, New York, NY 10001-6008, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PGF sub(2 alpha ) receptors in ovine luteal cells AN - 41248615; 1817195 AU - Balapure, A K AU - Watt, D S AU - Rexroad, CE Jr AU - Fitz, T A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41248615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=PGF+sub%282+alpha+%29+receptors+in+ovine+luteal+cells&rft.au=Balapure%2C+A+K%3BWatt%2C+D+S%3BRexroad%2C+CE+Jr%3BFitz%2C+T+A&rft.aulast=Balapure&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for the Study of Reproduction, 309 West Clark Street, Champaign, IL 61820 (USA). Telephone (217) 356-3182 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prognostic value of acute stress disorder and dissociation in trauma-naive and repeatedly traumatized community disaster populations AN - 41243029; 3288855 AU - Staab, J P AU - Grieger, T A AU - Fullerton, C S AU - Ursano, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41243029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Prognostic+value+of+acute+stress+disorder+and+dissociation+in+trauma-naive+and+repeatedly+traumatized+community+disaster+populations&rft.au=Staab%2C+J+P%3BGrieger%2C+T+A%3BFullerton%2C+C+S%3BUrsano%2C+R+J&rft.aulast=Staab&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association for the Advancement of Behavior Therapy, 305 7th Avenue, New York, NY 10001-6008, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anxiety sensitivity as a predictor of anxiety and panic during basic cadet training at the United States Air Force Academy AN - 41242672; 3289380 AU - Lerew AU - Schmidt, N B AU - Jackson, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41242672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Anxiety+sensitivity+as+a+predictor+of+anxiety+and+panic+during+basic+cadet+training+at+the+United+States+Air+Force+Academy&rft.au=Lerew%3BSchmidt%2C+N+B%3BJackson%2C+R+J&rft.aulast=Lerew&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association for the Advancement of Behavior Therapy, 305 7th Avenue, New York, NY 10001-6008, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extinction of anxiogenic and panicogenic effects of a 35% CO2 challenge in patients with panic disorder AN - 41242128; 3289378 AU - Trakowski, JH Jr AU - Schmidt, N B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41242128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Extinction+of+anxiogenic+and+panicogenic+effects+of+a+35%25+CO2+challenge+in+patients+with+panic+disorder&rft.au=Trakowski%2C+JH+Jr%3BSchmidt%2C+N+B&rft.aulast=Trakowski&rft.aufirst=JH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association for the Advancement of Behavior Therapy, 305 7th Avenue, New York, NY 10001-6008, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Bayesian microcomputer estimates of theophylline concentrations in newborn infants AN - 41211416; 1689496 AU - Gail Murphy, M AU - Peck, C C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41211416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluation+of+Bayesian+microcomputer+estimates+of+theophylline+concentrations+in+newborn+infants&rft.au=Gail+Murphy%2C+M%3BPeck%2C+C+C&rft.aulast=Gail+Murphy&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCPT Administrative Office, 1718 Gallagher Road, Norristown, PA 19401 (USA), Abstracts in Journal of Clinical Pharmacology and Therapeutics, vol. 43, no. 2, Feb 1988; booklet of abstracts $5.00 Abstract No. IVC-4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laser-enhanced transcutaneous collection of theophylline AN - 41207567; 1687657 AU - Conner, D P AU - Jacques, S L AU - Almirez, R G AU - McAuliffe, D J AU - Bolden, B J AU - Zamani, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41207567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Laser-enhanced+transcutaneous+collection+of+theophylline&rft.au=Conner%2C+D+P%3BJacques%2C+S+L%3BAlmirez%2C+R+G%3BMcAuliffe%2C+D+J%3BBolden%2C+B+J%3BZamani%2C+K&rft.aulast=Balapure&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCPT Administrative Office, 1718 Gallagher Road, Norristown, PA 19401 (USA), Abstracts in Journal of Clinical Pharmacology and Therapeutics, vol. 43, no. 2, Feb 1988; booklet of abstracts $5.00 Abstract No. PPI-1 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid upregulation and differential expression of B7 occurs during the course of a primary type 2 in vivo immune response AN - 41203308; 3248707 AU - Greenwald, R J AU - Urban, JF Jr AU - Lu, Pin AU - Nguyen, Huong AU - Finkelman, F AU - Gause, W C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41203308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Rapid+upregulation+and+differential+expression+of+B7+occurs+during+the+course+of+a+primary+type+2+in+vivo+immune+response&rft.au=Greenwald%2C+R+J%3BUrban%2C+JF+Jr%3BLu%2C+Pin%3BNguyen%2C+Huong%3BFinkelman%2C+F%3BGause%2C+W+C&rft.aulast=Greenwald&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 2526 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vivo regulation of NO- and iNOS mRNA expression: The role of macrophages and endogenous IFN- gamma AN - 41200312; 3248143 AU - Salkowski, CA AU - Detore, G AU - Vogel, S N Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41200312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vivo+regulation+of+NO-+and+iNOS+mRNA+expression%3A+The+role+of+macrophages+and+endogenous+IFN-+gamma&rft.au=Salkowski%2C+CA%3BDetore%2C+G%3BVogel%2C+S+N&rft.aulast=Salkowski&rft.aufirst=CA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 1961 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Either B7-1 or B7-2 interactions can provide the essential B7 costimulatory signals for an in vivo mucosal Th2-like response AN - 41190220; 3248709 AU - Gause, W C AU - Lu, P AU - Zhou, X D AU - Chen, S J AU - Finkelman, F D AU - Urban, JJ Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41190220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Either+B7-1+or+B7-2+interactions+can+provide+the+essential+B7+costimulatory+signals+for+an+in+vivo+mucosal+Th2-like+response&rft.au=Gause%2C+W+C%3BLu%2C+P%3BZhou%2C+X+D%3BChen%2C+S+J%3BFinkelman%2C+F+D%3BUrban%2C+JJ+Jr&rft.aulast=Gause&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 2528 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Flow-induced oscillations of a novel double-wing spring-mass system AN - 41190158; 1678002 AU - King, P I AU - Allen, G D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3000:CIVIL AND MECHANICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41190158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Flow-induced+oscillations+of+a+novel+double-wing+spring-mass+system&rft.au=King%2C+P+I%3BAllen%2C+G+D&rft.aulast=King&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASME, 22 Law Drive, P.O. Box 2900, Fairfield, NJ 07007-2900 (USA), Papers and proceedings volumes available airfield, NJ 07007-2900 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct pathways of B cell activation leading to humoral immunity AN - 41120973; 3201356 AU - Snapper, C M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41120973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Distinct+pathways+of+B+cell+activation+leading+to+humoral+immunity&rft.au=Snapper%2C+C+M&rft.aulast=Snapper&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc., 2 Madison Avenue, Larchmont, NY 10538. Phone: 914-834-3100, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Retinoic acid potentiates IFN beta -induced reversion of RAS-transformed cells and the transcription of the lysyl oxidase gene AN - 41114415; 3201467 AU - Yeh, A AU - Contente, S AU - Kenyon, K AU - Friedman, R M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41114415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Retinoic+acid+potentiates+IFN+beta+-induced+reversion+of+RAS-transformed+cells+and+the+transcription+of+the+lysyl+oxidase+gene&rft.au=Yeh%2C+A%3BContente%2C+S%3BKenyon%2C+K%3BFriedman%2C+R+M&rft.aulast=Yeh&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc., 2 Madison Avenue, Larchmont, NY 10538. Phone: 914-834-3100, Abstracts available. Paper No. P4-4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accurate flying qualities prediction during landing using loop separation parameter AN - 41026658; 1519200 AU - Martz, J AU - Biezad, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41026658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Accurate+flying+qualities+prediction+during+landing+using+loop+separation+parameter&rft.au=Martz%2C+J%3BBiezad%2C+D&rft.aulast=Martz&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08845 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - QFT digital flight control design as applied to the AFTI/F-16 AN - 41020765; 1519589 AU - Schneider, D L AU - Horowitz, I M AU - Houpis, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41020765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=QFT+digital+flight+control+design+as+applied+to+the+AFTI%2FF-16&rft.au=Schneider%2C+D+L%3BHorowitz%2C+I+M%3BHoupis%2C+C&rft.aulast=Schneider&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08845 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a microcomputer based work station for satellite link analysis AN - 41018977; 1518812 AU - Jackson, C B AU - Hibner, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41018977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Development+of+a+microcomputer+based+work+station+for+satellite+link+analysis&rft.au=Jackson%2C+C+B%3BHibner%2C+D&rft.aulast=Jackson&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08845 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Operating system simulator in Ada AN - 41011330; 1519269 AU - DeGroat, J W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41011330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Operating+system+simulator+in+Ada&rft.au=DeGroat%2C+J+W&rft.aulast=DeGroat&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08845 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computer software fault tolerance AN - 41009681; 1519293 AU - Ferens, D V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41009681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Computer+software+fault+tolerance&rft.au=Ferens%2C+D+V&rft.aulast=Ferens&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08845 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A review of satellite code division multiple access and a technique for determining the number of simultaneous accesses AN - 41009468; 1518828 AU - Stephens, J AU - Prescott, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41009468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=A+review+of+satellite+code+division+multiple+access+and+a+technique+for+determining+the+number+of+simultaneous+accesses&rft.au=Stephens%2C+J%3BPrescott%2C+G&rft.aulast=Stephens&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08845 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the error performance of a QPSK communication system in the presence of linear transmission distortion AN - 41009435; 1518169 AU - Horton, R S AU - Prescott, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41009435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+the+error+performance+of+a+QPSK+communication+system+in+the+presence+of+linear+transmission+distortion&rft.au=Horton%2C+R+S%3BPrescott%2C+G&rft.aulast=Horton&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08845 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microcomputer-based simulation and performance analysis of error correction codes AN - 41008368; 1518139 AU - Munger, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41008368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Microcomputer-based+simulation+and+performance+analysis+of+error+correction+codes&rft.au=Munger%2C+C&rft.aulast=Schoenberg&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08845 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Solving global, two-dimensional routing problems using snell's law and A-search AN - 41005218; 1477556 AU - Richbourg, R AU - Rowe, N AU - McGhee, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41005218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Solving+global%2C+two-dimensional+routing+problems+using+snell%27s+law+and+A-search&rft.au=Richbourg%2C+R%3BRowe%2C+N%3BMcGhee%2C+R&rft.aulast=Richbourg&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Robotics and Automation, Exeter C3037, Boca Raton, FL 33434 (USA), Price: $75.00 (IEEE members); $150.00 (non-members) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dielectric loss effects on the performance of a thin-film, uniformly-distributed RC notch network AN - 41005112; 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1517933 AU - Kearns, T G AU - Hartrum, T C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41002564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Rapid+data+retrieval+concepts+for+expert+database+systems&rft.au=Kearns%2C+T+G%3BHartrum%2C+T+C&rft.aulast=Kearns&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08845 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Application of a hybrid programmable transversal filter as a matched filter AN - 41001640; 1518126 AU - Murphy, M P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41001640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Application+of+a+hybrid+programmable+transversal+filter+as+a+matched+filter&rft.au=Murphy%2C+M+P&rft.aulast=Murphy&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, 445 Hoes Lane, Piscataway, NJ 08845 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms augmenting flow resistance of thrombotic coronary artery stenosis in pigs AN - 40996312; 1436396 AU - Laurindo, FRM AU - Ezra, D AU - Czaja, J F AU - Feuerstein, G Z AU - Goldstein, R E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40996312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mechanisms+augmenting+flow+resistance+of+thrombotic+coronary+artery+stenosis+in+pigs&rft.au=Laurindo%2C+FRM%3BEzra%2C+D%3BCzaja%2C+J+F%3BFeuerstein%2C+G+Z%3BGoldstein%2C+R+E&rft.aulast=Laurindo&rft.aufirst=FRM&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Heart Association, 7320 Greenville Avenue, Dallas, TX 75231 (USA), Abstract No. 974 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Error covariance analysis for tracking filters AN - 40934800; 1321924 AU - Gleason, D AU - Andrisani, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40934800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Error+covariance+analysis+for+tracking+filters&rft.au=Gleason%2C+D%3BAndrisani%2C+D&rft.aulast=Gleason&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IEEE Service Center, Publication Sales Department, 445 Hoes Lane, Piscataway, NJ 08854 (USA). 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Price -- $60 (members); $90 (non-members) Paper No. AIAA-85-1788-CP N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of estrogen antagonists on vitellogenin and albumin production in Xenopus laevis AN - 40807851; 1035250 AU - Riegel, A T AU - Schoenberg Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+estrogen+antagonists+on+vitellogenin+and+albumin+production+in+Xenopus+laevis&rft.au=Riegel%2C+A+T%3BSchoenberg&rft.aulast=Riegel&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Active control of helicopter blade flapping AN - 40802683; 1029507 AU - Calico, R A AU - March, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40802683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Active+control+of+helicopter+blade+flapping&rft.au=Calico%2C+R+A%3BMarch%2C+J&rft.aulast=Calico&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: AIAA, Marketing Dept., 1633 Broadway, New York, NY 10019, USA, Bound volumes available. Price -- $60 (members); $90 (non-members) Paper No. AIAA-85-1963-CP N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simultaneous pharmacokinetic-pharmacodynamic modeling of cimetidine in man AN - 40760124; 0907008 AU - Ezra, D AU - Abdelrahim, M AU - Esposito, R AU - Dubois, A AU - Peck, C C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Simultaneous+pharmacokinetic-pharmacodynamic+modeling+of+cimetidine+in+man&rft.au=Ezra%2C+D%3BAbdelrahim%2C+M%3BEsposito%2C+R%3BDubois%2C+A%3BPeck%2C+C+C&rft.aulast=Ezra&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Importance of assumptions in Bayesian pharmacokinetic control of drug therapy AN - 40757904; 0907048 AU - Peck, C C AU - Chen, B C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Importance+of+assumptions+in+Bayesian+pharmacokinetic+control+of+drug+therapy&rft.au=Peck%2C+C+C%3BChen%2C+B+C&rft.aulast=Peck&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Colonial waterbird population trends on Long Island, N.Y AN - 40745348; 0906684 AU - Buckley, P A AU - Buckley, F G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40745348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Colonial+waterbird+population+trends+on+Long+Island%2C+N.Y&rft.au=Buckley%2C+P+A%3BBuckley%2C+F+G&rft.aulast=Buckley&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ubiquitous antibodies (ab) to conserved lipopolysaccharide (LPS) core structures in normal human sera and immune globulins for intravenous use (IGIV) AN - 40705579; 0809504 AU - Stoll, B AU - Pollack, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ubiquitous+antibodies+%28ab%29+to+conserved+lipopolysaccharide+%28LPS%29+core+structures+in+normal+human+sera+and+immune+globulins+for+intravenous+use+%28IGIV%29&rft.au=Stoll%2C+B%3BPollack%2C+M&rft.aulast=Stoll&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Program and Abstracts of the 24th Interscience Conference on Antimicrobial Agents and Chemotherapy", 1984, ASM Publications Office, 1913 I Street, NW, Washington, DC 20006, USA, ISBN 0-914826-67-0; ISSN 0733-6373; Price: $10.00 Abstract No. 194 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of adriamycin on short circuit current across toad urinary bladder epithelium AN - 40601012; 0592895 AU - Chen, J S AU - Kang, Y H AU - Chen, B L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40601012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+adriamycin+on+short+circuit+current+across+toad+urinary+bladder+epithelium&rft.au=Chen%2C+J+S%3BKang%2C+Y+H%3BChen%2C+B+L&rft.aulast=Chen&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "The Physiologist", Aug 1983, American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA, ISSN 0031-9376 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computer processing of phrenic neurograms during step changes in end-tidal PCO sub(2) AN - 40596754; 0591838 AU - Bryant, HJ AU - Abbrecht, PH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40596754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Computer+processing+of+phrenic+neurograms+during+step+changes+in+end-tidal+PCO+sub%282%29&rft.au=Bryant%2C+HJ%3BAbbrecht%2C+PH&rft.aulast=Bryant&rft.aufirst=HJ&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "The Physiologist", Aug 1983, American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA, ISSN 0031-9376 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ventilatory responses to inspiratory flow resistive loading during steady state exercise AN - 40596719; 0591804 AU - Abbrecht, PH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40596719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ventilatory+responses+to+inspiratory+flow+resistive+loading+during+steady+state+exercise&rft.au=Abbrecht%2C+PH&rft.aulast=Abbrecht&rft.aufirst=PH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "The Physiologist", Aug 1983, American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA, ISSN 0031-9376 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Introduction and overview to farmland protection AN - 40586666; 0561322 AU - Rawlins, S L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40586666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Earthworm+burrowing+and+effects+on+soil+structure+and+transmissivity&rft.au=Kemper%2C+W+D&rft.aulast=Kemper&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Bound volume of abstracts available: American Society of Agronomy, 677 S. Segoe Road, Madison, WI 53711, USA, Price: $6.00 U.S.; $7.00 outside U.S. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Natural language understanding for military systems AN - 40586173; 0548889 AU - Milne, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 0500:AEROSPACE SCIENCES AND ENGINEERING KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40586173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Natural+language+understanding+for+military+systems&rft.au=Milne%2C+R&rft.aulast=Milne&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: AIAA, 1290 Avenue of the Americas, New York, NY 10014, USA, Order papers individually by paper number or within a bound proceedings. Price: $75 members; $85 non-members Paper no. AIAA-83-2315-CP N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered gastric emptying during radiation-induced vomiting AN - 40581592; 0539599 AU - Dubois, A AU - Jacobus, J AU - Grissom, M AU - Eng, R AU - Conklin, J J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40581592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Altered+gastric+emptying+during+radiation-induced+vomiting&rft.au=Dubois%2C+A%3BJacobus%2C+J%3BGrissom%2C+M%3BEng%2C+R%3BConklin%2C+J+J&rft.aulast=Dubois&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Jun. 1983, Abstracts booklet available: Society of Nuclear Medicine, 475 Park Avenue South, New York, N.Y. 10016, USA, Price: $5.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of ionizing radiations on gastric secretion in rhesus monkeys AN - 40574867; 0540322 AU - Dorval, ED AU - Eng, R AU - Colombaro, P AU - Durakovic, A AU - Conklin, J J AU - Dubois, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40574867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+ionizing+radiations+on+gastric+secretion+in+rhesus+monkeys&rft.au=Dorval%2C+ED%3BEng%2C+R%3BColombaro%2C+P%3BDurakovic%2C+A%3BConklin%2C+J+J%3BDubois%2C+A&rft.aulast=Dorval&rft.aufirst=ED&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Jun. 1983, Abstracts booklet available: Society of Nuclear Medicine, 475 Park Avenue South, New York, N.Y. 10016, USA, Price: $5.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mathematical modeling in the undergraduate curriculum AN - 40562505; 0497212 AU - Weir, MD Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5000:GENERAL ENGINEERING AND TECHNOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40562505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mathematical+modeling+in+the+undergraduate+curriculum&rft.au=Weir%2C+MD&rft.aulast=Weir&rft.aufirst=MD&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Proceedings available: "1983 Annual Conference Proceedings", 1983, ASEE Publication Sales, 11 Dupont Circle, Suite 200, Washington, DC 20036, USA, 3 vol. set; Price: $45.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NPSR, a system for computer aided design and drafting of pipe supports and restraints AN - 40555426; 0501936 AU - Levine, J P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3000:CIVIL AND MECHANICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=NPSR%2C+a+system+for+computer+aided+design+and+drafting+of+pipe+supports+and+restraints&rft.au=Levine%2C+J+P&rft.aulast=Levine&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1983, ASME Order Dep., P.O. Box 3199, Grand Central Station, New York, NY 10163, USA, Papers may be ordered individually by paper number or as a paper within a bound volume. Papers $2.50 each/members; $5.00 each/nonmembers Bound Volume H00260 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synoptic scale variability in the California Current AN - 40516029; 0376470 AU - Mooers, CNK AU - Robinson, A R AU - Smith, JA AU - Rienecker, M M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 5500:GEOSCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40516029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Picroliv+prevents+cell+death+during+hepatocellular+remodeling+following+ischemia-reperfusion+injury&rft.au=Singh%2C+A+K%3BMani%2C+H%3BBanaudha%2C+K+K%3BKulshreshtha%2C+D+K%3BSharma%2C+S+K%3BMaheshwari%2C+R+K&rft.aulast=Singh&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "EOS, Transactions, American Geophysical Union", Nov. 9, 1982, American Geophysical Union, 2000 Florida Avenue, N.W., Washington, DC 20009, USA, ISSN: 0096-3941, Single Issue $10.00 Abstract No. O41B-13 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computer-Assisted Instruction and Diagnosis of Radiographic Findings AN - 40504470; 0326261 AU - Harper, DA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40504470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Computer-Assisted+Instruction+and+Diagnosis+of+Radiographic+Findings&rft.au=Harper%2C+DA&rft.aulast=Harper&rft.aufirst=DA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Proceedings in: "Systems Techniques -- Economic Reality in the 80s", 1982, AAMSI, 4405 East-West Highway, Bethesda, MD 20814, USA, ISSN 0735-0694; 166 pages N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Leukotrienes Produce Coronary Constriction in the Intact Pig Heart AN - 40489929; 0310880 AU - Boyd, L AU - Ezra, D AU - Feuerstein, G AU - Goldstein, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40489929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Leukotrienes+Produce+Coronary+Constriction+in+the+Intact+Pig+Heart&rft.au=Boyd%2C+L%3BEzra%2C+D%3BFeuerstein%2C+G%3BGoldstein%2C+R&rft.aulast=Boyd&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: CIRCULATION, Oct. 1982, American Heart Association, Distribution Center, 2005 Hightower, Garland, TX 75041, USA, Monograph No. 91 73-077A; Price: $10.00 Abstract No. 1033 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic Arachidonic Acid Administration in Hypertensive Rats AN - 40484799; 0308354 AU - Ezra, D AU - Bayorh, MA AU - Zukowska-Grojec, Z AU - Lazar, J D AU - Kopin, I J AU - Feuerstein, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40484799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chronic+Arachidonic+Acid+Administration+in+Hypertensive+Rats&rft.au=Ezra%2C+D%3BBayorh%2C+MA%3BZukowska-Grojec%2C+Z%3BLazar%2C+J+D%3BKopin%2C+I+J%3BFeuerstein%2C+G&rft.aulast=Ezra&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: CIRCULATION, Oct. 1982, American Heart Association, Distribution Center, 2005 Hightower, Garland, TX 75041, USA, Monograph No. 91 73-077A; Price: $10.00 Abstract No. 653 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fast Axonal Transport in Permeabilized Lobster Giant Axons AN - 40482583; 0299219 AU - Forman, D S AU - Brown, K J AU - Livergood Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40482583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Fast+Axonal+Transport+in+Permeabilized+Lobster+Giant+Axons&rft.au=Forman%2C+D+S%3BBrown%2C+K+J%3BLivergood&rft.aulast=Forman&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 237.5 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tachycardia Does Not Alter Minimal Coronary Flow Necessary for Survival of Myocardium AN - 40436911; 0207096 AU - Davenport, N J AU - Ro, Y M AU - Goldstein, R E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40436911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tachycardia+Does+Not+Alter+Minimal+Coronary+Flow+Necessary+for+Survival+of+Myocardium&rft.au=Davenport%2C+N+J%3BRo%2C+Y+M%3BGoldstein%2C+R+E&rft.aulast=Davenport&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Rise in Left Ventricular Filling Pressure on Coronary Collateral Function AN - 40434345; 0206892 AU - Bolli, R AU - Goldstein, R E AU - Brandon, T A AU - Miller, R R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40434345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+Rise+in+Left+Ventricular+Filling+Pressure+on+Coronary+Collateral+Function&rft.au=Bolli%2C+R%3BGoldstein%2C+R+E%3BBrandon%2C+T+A%3BMiller%2C+R+R&rft.aulast=Bolli&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extent of Reperfusion Blood Flow Predicts Myocardial Survival AN - 40431217; 0208209 AU - Ro, Y M AU - Davenport, N J AU - Goldstein, R E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40431217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Extent+of+Reperfusion+Blood+Flow+Predicts+Myocardial+Survival&rft.au=Ro%2C+Y+M%3BDavenport%2C+N+J%3BGoldstein%2C+R+E&rft.aulast=Ro&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Beta-Endorphin Immunoreactivity in Rat Plasma: Variations in Response to Different Physical Stimuli AN - 40406494; 0142320 AU - Mueller, G P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40406494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Beta-Endorphin+Immunoreactivity+in+Rat+Plasma%3A+Variations+in+Response+to+Different+Physical+Stimuli&rft.au=Mueller%2C+G+P&rft.aulast=Mueller&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 45.3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Strategy and serendipity in the discovery of calcimimetics AN - 39242758; 3552275 AU - Nemeth, E F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500: Pharmacology KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39242758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Strategy+and+serendipity+in+the+discovery+of+calcimimetics&rft.au=Nemeth%2C+E+F&rft.aulast=Nemeth&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: IBC USA Conferences, Inc., One Research Drive, Suite 400 A, P.O. Box 5195, Westborough, MA 01581-5195, USA; phone: 508-616-5550; fax: 508-616-5522; email: custserv@ibcusa.com; URL: www.drugdisc.com/worldcongress/, copies of abstracts are available for $499 commercial, $299 academic N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Rasputin affects actin dynamics in developing egg chambers AN - 39211977; 3518906 AU - Pazman, C AU - Haynes, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39211977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Rasputin+affects+actin+dynamics+in+developing+egg+chambers&rft.au=Pazman%2C+C%3BHaynes%2C+S&rft.aulast=Pazman&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Genetics Society of America, 9650 Rockville Pike, Bethesda, Md 20814-3998, USA; phone: (301) 571-1825; fax: (301) 530-7079; email: society@genetics.faseb.org; URL: http://www.faseb.org/genetics/gsa/gsamenu.htm. Paper No. 447B N1 - Last updated - 2011-10-26 ER - TY - JOUR T1 - Leptin and TGF-beta synergistically regulate VIP cytokine response element transcription. AN - 72507648; 11192627 AB - Leptin was originally described as an adipocyte-derived cytokine that signals to the hypothalamus to regulate food intake and energy expenditure. Leptin signals through the Ob receptor, which is closely related to the gp130 cytokine receptor. Here we show that leptin can induce expression of the neuropeptide gene vasoactive intestinal peptide (VIP) through the VIP cytokine response element, the same element that mediates the response to the gp130 cytokines. Leptin acts synergistically with TGF-beta to activate transcription through this element. Transcriptional responses to leptin are increased when transmitted through ObR mutated at Tyr986, the SHP-2 docking domain, yet this mutation does not alter the synergy between TGF-beta and leptin. These data emphasize the functional similarity between leptin and the gp130 cytokines. JF - Neuroreport AU - Jones, E AU - Symes, A AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 2000/12/18/ PY - 2000 DA - 2000 Dec 18 SP - 4049 EP - 4053 VL - 11 IS - 18 SN - 0959-4965, 0959-4965 KW - Carrier Proteins KW - 0 KW - Leptin KW - Receptors, Cell Surface KW - Receptors, Leptin KW - Transforming Growth Factor beta KW - leptin receptor, human KW - Vasoactive Intestinal Peptide KW - 37221-79-7 KW - Index Medicus KW - Signal Transduction -- physiology KW - Promoter Regions, Genetic -- physiology KW - Animals KW - Promoter Regions, Genetic -- drug effects KW - Transfection KW - Cells, Cultured KW - Humans KW - Signal Transduction -- drug effects KW - Drug Interactions -- physiology KW - Transforming Growth Factor beta -- pharmacology KW - Carrier Proteins -- metabolism KW - Transcription, Genetic -- drug effects KW - Carrier Proteins -- genetics KW - Leptin -- metabolism KW - Carrier Proteins -- drug effects KW - Response Elements -- genetics KW - Leptin -- pharmacology KW - Response Elements -- drug effects KW - Transforming Growth Factor beta -- metabolism KW - Vasoactive Intestinal Peptide -- genetics KW - Vasoactive Intestinal Peptide -- drug effects KW - Transcription, Genetic -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72507648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroreport&rft.atitle=Leptin+and+TGF-beta+synergistically+regulate+VIP+cytokine+response+element+transcription.&rft.au=Jones%2C+E%3BSymes%2C+A&rft.aulast=Jones&rft.aufirst=E&rft.date=2000-12-18&rft.volume=11&rft.issue=18&rft.spage=4049&rft.isbn=&rft.btitle=&rft.title=Neuroreport&rft.issn=09594965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-29 N1 - Date created - 2001-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure and regulation of mammalian squalene synthase. AN - 72466895; 11111077 AB - Mammalian squalene synthase (SQS) catalyzes the first reaction of the branch of the isoprenoid metabolic pathway committed specifically to sterol biosynthesis. SQS produces squalene in an unusual two-step reaction in which two molecules of farnesyl diphosphate are condensed head-to-head. Recent studies have advanced understanding of the reaction mechanism, the functional domains of the enzyme, and transcriptional regulation of the gene. Site-directed mutagenesis has identified conserved Asp, Tyr, and Phe residues that are essential for SQS activity. The Asp residues are hypothesized to be required for substrate binding; the Tyr and Phe residues may stabilize carbocation reaction intermediates. The elucidation of SQS crystal structure will most likely direct future research on the relationship between enzyme structure and function. SQS activity, protein, and mRNA levels are regulated by cholesterol status and by the cytokines TNF-alpha and IL-1beta. Activation of the SQS promoter in response to cholesterol deficit is mediated by sterol regulatory element binding proteins SREBP-1a and SREBP-2. The precise contributions made by individual SREBPs and accessory transcription factors to SQS transcriptional control, and the mechanisms underlying cytokine regulation of SQS are major foci of current research. JF - Biochimica et biophysica acta AU - Tansey, T R AU - Shechter, I AD - Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, 430l Jones Bridge Road, Bethesda, MD 20814-4799, USA. Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 49 EP - 62 VL - 1529 IS - 1-3 SN - 0006-3002, 0006-3002 KW - CCAAT-Enhancer-Binding Proteins KW - 0 KW - DNA-Binding Proteins KW - SREBF1 protein, human KW - SREBF2 protein, human KW - Sterol Regulatory Element Binding Protein 1 KW - Sterol Regulatory Element Binding Protein 2 KW - Transcription Factors KW - Squalene KW - 7QWM220FJH KW - Cholesterol KW - 97C5T2UQ7J KW - Oxidoreductases KW - EC 1.- KW - Farnesyl-Diphosphate Farnesyltransferase KW - EC 2.5.1.21 KW - Index Medicus KW - Squalene -- metabolism KW - Animals KW - Liver -- enzymology KW - CCAAT-Enhancer-Binding Proteins -- pharmacology KW - Enzyme Activation KW - Humans KW - DNA-Binding Proteins -- pharmacology KW - DNA-Binding Proteins -- genetics KW - Transcription, Genetic KW - Amino Acid Sequence KW - Transcription Factors -- genetics KW - Transcription Factors -- pharmacology KW - Promoter Regions, Genetic KW - Base Sequence KW - Gene Expression Regulation, Enzymologic KW - Cholesterol -- biosynthesis KW - Transfection KW - Kinetics KW - Molecular Sequence Data KW - Models, Chemical KW - CCAAT-Enhancer-Binding Proteins -- genetics KW - Cell Line KW - Oxidoreductases -- genetics KW - Farnesyl-Diphosphate Farnesyltransferase -- genetics KW - Oxidoreductases -- chemistry KW - Farnesyl-Diphosphate Farnesyltransferase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72466895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Structure+and+regulation+of+mammalian+squalene+synthase.&rft.au=Tansey%2C+T+R%3BShechter%2C+I&rft.aulast=Tansey&rft.aufirst=T&rft.date=2000-12-15&rft.volume=1529&rft.issue=1-3&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2001-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolic effects of 1-methyl-4-phenylpyridinium (MPP(+)) in primary neuron cultures. AN - 72459221; 11107166 AB - Disruption of mitochondrial function has been proposed as an action of 1-methyl-4-phenylpyridinium (MPP(+)) that is responsible for its toxicity. In order to characterize effects of MPP(+) on energy metabolism in primary culture neurons, we monitored levels of several metabolites in cultured rat cerebellar granule cells exposed to MPP(+). The toxin produced a rapid concentration-dependent reduction in intracellular phosphocreatine (PCr), amounting to a 50-80% decrease within 30-60 min at 50 microM, that was maintained through the 1 week exposure interval examined. In contrast, ATP levels remained comparable to those of untreated neurons for approximately 4 days, at that time a 50% reduction in ATP was observed in association with a decrease in cell viability. Acute decreases in PCr were accompanied by increases in creatine such that the total creatine levels were maintained. Lactate levels in the culture medium were significantly increased (from 4.5 to 6.0 mM) within 6 hr after addition of MPP(+), with a concentration dependence similar to that observed for the reduction in PCr. Increased lactate production in the presence of MPP(+) coincided with a more rapid depletion of glucose in the culture medium. MPP(+) induced a rapid and sustained decrease in intracellular pH calculated from the creatine kinase equilibrium, and this acidification is considered primarily responsible for the observed decrease in PCr. These studies provide direct evidence that toxic concentrations of MPP(+) have acute effects on energy metabolism in primary culture neurons, consistent with an increased dependence on glycolysis to meet metabolic demand, but indicate that toxicity is not associated with overt, immediate failure to maintain cellular ATP. Copyright 2000 Wiley-Liss, Inc. JF - Journal of neuroscience research AU - Marini, A M AU - Nowak, T S AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. amarini@usuhs.mil Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 814 EP - 820 VL - 62 IS - 6 SN - 0360-4012, 0360-4012 KW - Herbicides KW - 0 KW - Phosphocreatine KW - 020IUV4N33 KW - Lactic Acid KW - 33X04XA5AT KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Glucose KW - IY9XDZ35W2 KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Rats KW - Animals KW - Cells, Cultured KW - Glucose -- metabolism KW - Cerebellum KW - Lactic Acid -- metabolism KW - Neurons -- metabolism KW - Herbicides -- pharmacology KW - Neurons -- drug effects KW - Adenosine Triphosphate -- metabolism KW - Phosphocreatine -- metabolism KW - Phosphocreatine -- drug effects KW - 1-Methyl-4-phenylpyridinium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72459221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=Metabolic+effects+of+1-methyl-4-phenylpyridinium+%28MPP%28%2B%29%29+in+primary+neuron+cultures.&rft.au=Marini%2C+A+M%3BNowak%2C+T+S&rft.aulast=Marini&rft.aufirst=A&rft.date=2000-12-15&rft.volume=62&rft.issue=6&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-26 N1 - Date created - 2001-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Optimal sample preparation conditions for the determination of uranium in biological samples by kinetic phosphorescence analysis (KPA) AN - 17768173; 4822189 AB - Kinetic phosphorescence analysis (KPA) is a proven technique for rapid, precise, and accurate determination of uranium in aqueous solutions. Uranium analysis of biological samples require dry-ashing in a muffle furnace between 400 and 600 degree C followed by wet-ashing with concentrated nitric acid and hydrogen peroxide to digest the organic component in the sample that interferes with uranium determination by KPA. The optimal dry-ashing temperature was determined to be 450 degree C. At dry-ashing temperatures greater than 450 degree C, uranium loss was attributed to vaporization. High temperatures also caused increased background values that were attributed to uranium leaching from the glass vials. Dry-ashing temperatures less than 450 degree C result in the samples needing additional wet-ashing steps. The recovery of uranium in urine samples was 99.2 plus or minus 4.02% between spiked concentrations of 1.98-1980 ng (0.198-198 mu g l super(-1)) uranium, whereas the recovery in whole blood was 89.9 plus or minus 7.33% between the same spiked concentrations. The limit of quantification in which uranium in urine and blood could be accurately measured above the background was determined to be 0.05 and 0.6 mu g l super(-1), respectively. JF - Journal of Pharmaceutical and Biomedical Analysis AU - Ejnik, J W AU - Hamilton, M M AU - Adams, PR AU - Carmichael, A J AD - Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA, ejnik@mx.afrri.usuhs.mil Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 227 EP - 235 VL - 24 IS - 2 SN - 0731-7085, 0731-7085 KW - man KW - kinetic phosphorescence analysis KW - Toxicology Abstracts KW - Uranium KW - Body fluids KW - X 24210:Radiation & radioactive materials KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17768173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.atitle=Optimal+sample+preparation+conditions+for+the+determination+of+uranium+in+biological+samples+by+kinetic+phosphorescence+analysis+%28KPA%29&rft.au=Ejnik%2C+J+W%3BHamilton%2C+M+M%3BAdams%2C+PR%3BCarmichael%2C+A+J&rft.aulast=Ejnik&rft.aufirst=J&rft.date=2000-12-15&rft.volume=24&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.issn=07317085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Uranium; Body fluids ER - TY - JOUR T1 - B7 Requirements for Primary and Secondary Protein- and Polysaccharide-Specific Ig Isotype Responses to Streptococcus pneumoniae AN - 17739535; 4808102 AB - The requirements for B7 costimulation during an in vivo humoral response to an intact extracellular bacteria have not been reported. In this study we immunized mice with Streptococcus pneumoniae (R36A) to determine the B7 requirements for induction of Ig, specific for two determinants on R36A, the phosphorylcholine (PC) determinant of C-polysaccharide and pneumococcal surface protein A (PspA). We show that the primary anti-PspA response, the development of PspA-specific memory, and the induction of the secondary anti-PspA response in primed mice were completely dependent upon B7 costimulation. Of note, costimulation was required only briefly after the secondary immunization compared with after the primary immunization for optimal induction of Ig. Blockade of B7 costimulation at the time of secondary immunization also completely abrogated the established state of memory, but did not induce tolerance. In contrast to the anti-PspA response, the primary anti-PC response involved only a very short period of B7 costimulation. Whereas B7-2 alone was required for induction of the primary anti-PspA and anti-PC responses, a redundant role for B7-1 and B7-2 was noted for the PspA-specific secondary response. CTLA4Ig blocked both the anti-PC and anti-PspA responses equally well over a wide range of bacterial doses. These studies demonstrate a critical, but variable, role for B7-dependent costimulation during an Ig response to an extracellular bacteria. JF - Journal of Immunology AU - Wu, Z-Q AU - Khan, A Q AU - Shen, Y AU - Schartman, J AU - Peach, R AU - Lees, A AU - Mond, J J AU - Gause, W C AU - Snapper, C M AD - Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA, csnapper@usuhs.mil Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 6840 EP - 6848 VL - 165 IS - 12 SN - 0022-1767, 0022-1767 KW - immunology KW - Streptococcus pneumoniae KW - double prime B7 antigen KW - phosphorylcholine KW - surface protein A KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - B7 antigen KW - ^AB7 antigen KW - Immune response (humoral) KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17739535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=B7+Requirements+for+Primary+and+Secondary+Protein-+and+Polysaccharide-Specific+Ig+Isotype+Responses+to+Streptococcus+pneumoniae&rft.au=Wu%2C+Z-Q%3BKhan%2C+A+Q%3BShen%2C+Y%3BSchartman%2C+J%3BPeach%2C+R%3BLees%2C+A%3BMond%2C+J+J%3BGause%2C+W+C%3BSnapper%2C+C+M&rft.aulast=Wu&rft.aufirst=Z-Q&rft.date=2000-12-15&rft.volume=165&rft.issue=12&rft.spage=6840&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Immune response (humoral) ER - TY - JOUR T1 - Rhabdomyolysis associated with nutritional supplement use. AN - 733875441; 19078495 AB - The use of alternative medicine in the United States has increased over the past 2 decades. With increasing use, the possibility of toxicity also increases. We report two cases of rhabdomyolysis related to the use of two nutritional supplements: Diet Fuel and GlutaMASS. Each of these patients was a young, healthy male who was on a steady training regimen. A review of the literature and of the U.S. Food and Drug Administration's database revealed several reports of serious adverse events associated with these supplements and their ingredients. We hypothesize that the use of the supplements combined with normal physical training activities resulted in serious muscle injury. JF - Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases AU - Scroggie, D A AU - Harris, M AU - Sakai, L AD - Wilford Hall Medical Center, Lackland AFB, Texas; Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 328 EP - 332 VL - 6 IS - 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733875441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+rheumatology+%3A+practical+reports+on+rheumatic+%26+musculoskeletal+diseases&rft.atitle=Rhabdomyolysis+associated+with+nutritional+supplement+use.&rft.au=Scroggie%2C+D+A%3BHarris%2C+M%3BSakai%2C+L&rft.aulast=Scroggie&rft.aufirst=D&rft.date=2000-12-01&rft.volume=6&rft.issue=6&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+rheumatology+%3A+practical+reports+on+rheumatic+%26+musculoskeletal+diseases&rft.issn=1536-7355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical challenges in menopausal management: a case study approach. AN - 72566739; 11220021 AB - Selecting an appropriate hormone replacement regimen can pose many challenges to the clinician and the patient. This report offers 4 case studies and clinical considerations illustrating both scientific and clinical considerations when collaborating with women to find an acceptable method to manage menopausal symptoms. Both traditional and complementary therapies are considered. JF - Nurse practitioner forum AU - Provencher, G C AU - McMullen, P C AU - Seibert, D C AD - Department of Nurse Practitioner, Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. proaspen@gateway.net Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 238 EP - 243 VL - 11 IS - 4 SN - 1045-5485, 1045-5485 KW - Estrogens KW - 0 KW - Progesterone KW - 4G7DS2Q64Y KW - Nursing KW - Humans KW - Middle Aged KW - Female KW - Estrogen Replacement Therapy KW - Progesterone -- adverse effects KW - Nurse Practitioners KW - Progesterone -- administration & dosage KW - Estrogens -- adverse effects KW - Menopause KW - Estrogens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72566739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+practitioner+forum&rft.atitle=Clinical+challenges+in+menopausal+management%3A+a+case+study+approach.&rft.au=Provencher%2C+G+C%3BMcMullen%2C+P+C%3BSeibert%2C+D+C&rft.aulast=Provencher&rft.aufirst=G&rft.date=2000-12-01&rft.volume=11&rft.issue=4&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Nurse+practitioner+forum&rft.issn=10455485&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-29 N1 - Date created - 2001-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Median effective dose determination and histologic characterization of porcine (Sus scrofa domestica) dermal lesions induced by 1540-nm laser radiation pulses. AN - 72542689; 11200570 AB - Light amplification by stimulated emission of radiation (laser) systems operating in the so-called "eye safe" region are gaining widespread use in industry, medicine, and military applications. This research effort was geared to study the effects of laser tissue interaction on human skin by using in vivo porcine skin as an animal model. The goals of the study were to determine the median effective dose (ED50) for 1540-nm laser exposures, to evaluate the Yorkshire pig and the Yucatan mini-pig as animal models for laser exposure, and to characterize laser-induced skin lesions histologically. A 1540-nm wavelength laser was used to expose multiple sites on the flanks of 10 pigs, using 0.8-ms pulses, ranging from 7 to 96 joules (J)/cm2. Single pulses were delivered to the flank of Yorkshire and Yucatan pigs in a grid pattern. Exposure sites were evaluated immediately after exposure and at 1 hour and 24 hours for presence of gross lesions. Representative biopsy specimens were collected from lesion sites for histologic evaluation at the 24-hour endpoint. The ED50 for the two breeds differed in the amount of energy required to induce dermal lesions. Grossly, lesions in each breed were well demarcated and pale gray to brightly erythematous. Microscopically, lesions had epidermal layer damage as cellular swelling and nuclear pyknosis, loss of cellular detail, and coagulation necrosis at the dermal layer. Findings suggest the presence of a different mechanism of laser-tissue damage in these two breeds. Photo-thermal mechanism appears to induce the skin lesions in the Yorkshire pig, whereas photo-thermal and photochemical mechanisms appear to be involved in lesion formation in the Yucatan mini-pig. All data obtained in this study will become part of database used by the American National Standards Institute (ANSI) to recommend laser safety standards for the occupational health and safety programs (OHSP), which will be used by industry and the military to base and update their current OHSP. JF - Comparative medicine AU - Rico, P J AU - Johnson, T E AU - Mitchell, M A AU - Saladino, B H AU - Roach, W P AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 633 EP - 638 VL - 50 IS - 6 SN - 1532-0820, 1532-0820 KW - Index Medicus KW - Swine KW - Models, Animal KW - Animals KW - Humans KW - Disease Models, Animal KW - Laser Therapy KW - Dose-Response Relationship, Radiation KW - Swine, Miniature KW - Species Specificity KW - Female KW - Skin -- radiation effects KW - Skin -- pathology KW - Lasers -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72542689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+medicine&rft.atitle=Median+effective+dose+determination+and+histologic+characterization+of+porcine+%28Sus+scrofa+domestica%29+dermal+lesions+induced+by+1540-nm+laser+radiation+pulses.&rft.au=Rico%2C+P+J%3BJohnson%2C+T+E%3BMitchell%2C+M+A%3BSaladino%2C+B+H%3BRoach%2C+W+P&rft.aulast=Rico&rft.aufirst=P&rft.date=2000-12-01&rft.volume=50&rft.issue=6&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Comparative+medicine&rft.issn=15320820&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-12 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interannual and Interdecadal Variations of the East Asian Summer Monsoon and Tropical Pacific SSTs. Part I: Roles of the Subtropical Ridge AN - 20671038; 9409992 AB - The interannual relationship between the East Asian summer monsoon and the tropical Pacific SSTs is studied using rainfall data in the Yangtze River Valley and the NCEP reanalysis for 1951-96. The datasets are also partitioned into two periods, 1951-77 and 1978-96, to study the interdecadal variations of this relationship. A wet summer monsoon is preceded by a warm equatorial eastern Pacific in the previous winter and followed by a cold equatorial eastern Pacific in the following fall. This relationship involves primarily the rainfall during the pre-Mei-yu/Mei-yu season (May-June) but not the post-Mei-yu season (July-August). In a wet monsoon year, the western North Pacific subtropical ridge is stronger as a result of positive feedback that involves the anomalous Hadley and Walker circulations, an atmospheric Rossby wave response to the western Pacific complementary cooling, and the evaporation-wind feedback. This ridge extends farther to the west from the previous winter to the following fall, resulting in an 850-hPa anomalous anticyclone near the southeast coast of China. This anticyclone 1) blocks the pre-Mei-yu and Mei-yu fronts from moving southward thereby extending the time that the fronts produce stationary rainfall; 2) enhances the pressure gradient to its northwest resulting in a more intense front; and 3) induces anomalous warming of the South China Sea surface through increased downwelling, which leads to a higher moisture supply to the rain area. A positive feedback from the strong monsoon rainfall also appears to occur, leading to an intensified anomalous anticyclone near the monsoon region. This SST-subtropical ridge-monsoon rainfall relationship is observed in both the interannual timescale within each interdecadal period and in the interdecadal scale. The SST anomalies (SSTAs) change sign in northern spring and resemble a tropospheric biennial oscillation (TBO) pattern during the first interdecadal period (1951-77). In the second interdecadal period (1978-96) the sign change occurs in northern fall and the TBO pattern in the equatorial eastern Pacific SST is replaced by longer timescales. This interdecadal variation of the monsoon-SST relationship results from the interdecadal change of the background state of the coupled ocean-atmosphere system. This difference gives rise to the different degrees of importance of the feedback from the anomalous circulations near the monsoon region to the equatorial eastern Pacific. In a wet monsoon year, the anomalous easterly winds south of the monsoon-enhanced anomalous anticyclone start to propagate slowly eastward toward the eastern Pacific in May and June, apparently as a result of an atmosphere-ocean coupled wave motion. These anomalous easterlies carry with them a cooling effect on the ocean surface. In 1951-77 this effect is insignificant as the equatorial eastern Pacific SSTAs, already change from warm to cold in northern spring, probably as a result of negative feedback processes discussed in ENSO mechanisms. In 1978-96 the equatorial eastern Pacific has a warmer mean SST. A stronger positive feedback between SSTA and the Walker circulation during a warm phase tends to keep the SSTA warm until northern fall, when the eastward-propagating anomalous easterly winds reach the eastern Pacific and reverse the SSTA. JF - Journal of Climate AU - Chang, C-P AU - Zhang, Yongsheng AU - Li, Tim AD - Department of Meteorology, Naval Postgraduate School, Monterey, California Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 4310 EP - 4325 PB - American Meteorological Society, 45 Beacon St. VL - 13 IS - 24 SN - 0894-8755, 0894-8755 KW - Meteorological & Geoastrophysical Abstracts; Water Resources Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Rainfall KW - Positive feedback KW - Atmospheric circulation-oceanic circulation coupled models KW - Seasonal variability KW - Wind KW - Monsoon rainfall KW - Weather KW - Downwelling KW - Mei-yu front KW - Easterly winds KW - Atmospheric circulation KW - Cooling KW - Surface temperature KW - Atmosphere-ocean coupled models KW - ISEW, South China Sea KW - Fronts KW - Tropical environment KW - El Nino-Southern Oscillation event KW - Mei-yu season KW - Monsoons KW - Rossby waves KW - Sea surface KW - China, People's Rep., Changjiang R. KW - Rainfall data KW - IS, Tropical Pacific KW - Data reanalysis KW - Sea surface temperature anomalies KW - Wave motion KW - IN, North Pacific KW - Ocean-atmosphere system KW - Waves KW - IN, Pacific KW - Anticyclones KW - Sea surface temperatures KW - Walker circulation KW - Coasts KW - Marine KW - Summer monsoon KW - Planetary waves KW - Climates KW - Ocean circulation KW - Oceanic circulation KW - Interannual variability KW - Negative feedback KW - Tropospheric biennial oscillation KW - Monsoon circulation KW - O 2010:Physical Oceanography KW - SW 0835:Streamflow and runoff KW - M2 551.58:Climatology (551.58) KW - Q2 09261:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20671038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Climate&rft.atitle=Interannual+and+Interdecadal+Variations+of+the+East+Asian+Summer+Monsoon+and+Tropical+Pacific+SSTs.+Part+I%3A+Roles+of+the+Subtropical+Ridge&rft.au=Chang%2C+C-P%3BZhang%2C+Yongsheng%3BLi%2C+Tim&rft.aulast=Chang&rft.aufirst=C-P&rft.date=2000-12-01&rft.volume=13&rft.issue=24&rft.spage=4310&rft.isbn=&rft.btitle=&rft.title=Journal+of+Climate&rft.issn=08948755&rft_id=info:doi/10.1175%2F1520-0442%282000%290132.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sea surface; Planetary waves; Tropical environment; Ocean-atmosphere system; Ocean circulation; Atmospheric circulation; Anticyclones; Surface temperature; Monsoons; Rossby waves; Rainfall data; Positive feedback; Atmospheric circulation-oceanic circulation coupled models; Data reanalysis; Sea surface temperature anomalies; Wave motion; Seasonal variability; Walker circulation; Sea surface temperatures; Monsoon rainfall; Summer monsoon; Mei-yu front; Downwelling; Easterly winds; Interannual variability; Oceanic circulation; Atmosphere-ocean coupled models; Fronts; Negative feedback; Tropospheric biennial oscillation; El Nino-Southern Oscillation event; Monsoon circulation; Mei-yu season; Weather; Rainfall; Climates; Waves; Cooling; Wind; Coasts; China, People's Rep., Changjiang R.; ISEW, South China Sea; IN, North Pacific; IN, Pacific; IS, Tropical Pacific; Marine DO - http://dx.doi.org/10.1175/1520-0442(2000)013<4310:IAIVOT>2.0.CO;2 ER - TY - JOUR T1 - Interannual and Interdecadal Variations of the East Asian Summer Monsoon and Tropical Pacific SSTs. Part II: Meridional Structure of the Monsoon AN - 20669835; 9409993 AB - The relationship between the interannual variations of the East Asian summer monsoon and that of the tropical SST shows considerable variations. In this study, rainfall in the southeastern coastal area of China (SEC) during 1951-96 is used to composite the tropical SST, 850-hPa wind, and 500-hPa height. The results relative to the May-June rainfall, which represents most of the SEC summer monsoon rainfall, are compared to the Yangtze River Valley (YRV) rainfall composites. It is shown that strong interdecadal changes in the Pacific may account for the observed variations in the meridional structure of the monsoon-SST relationship. The western Pacific 500-hPa subtropical ridge, which is influenced by the equatorial eastern Pacific SST, is crucial to these variations. During 1951-77 the SEC wet phase is produced by an anomalous anticyclone in the northern South China Sea, which tends to make the monsoon pre-Mei-yu and Mei-yu fronts quasi-stationary in the general area of both SEC and YRV, and also helps to warm the SST in the northern South China Sea. In this case the monsoon rainfalls in the two regions are in phase. During 1978-96 the mean equatorial eastern Pacific SST is higher, leading to a stronger and more expansive mean western Pacific subtropical ridge. Its proximity to the SEC region causes the latter to experience a strong interdecadal change, with less mean rainfall than 1951-77. Within the 1978-96 period, the anomalous anticyclone sustaining the YRV wet phase is situated near SEC, suppressing the SEC rainfall. Therefore the SEC and YRV rainfalls become out of phase. The SEC wet phase in 1978-96 depends on an anomalous 850-hPa cyclone in the East China Sea. This anomalous cyclone, which transports moist air onshore from the east resulting in maximum moisture convergence in SEC, develops when the western Pacific subtropical ridge is weak and displaced equatorward. The flow is more baroclinic and the monsoon fronts are active in the southeast coastal area. In this case the SEC and YRV rainfalls are uncorrelated. The July and August SEC wet phases show opposite characteristics. The wet July phase depends on anomalous 850-hPa cyclonic circulation in the northern South China Sea (and the East China Sea during 1951-77), which requires a retreat of the western edge of the western Pacific subtropical ridge. The anomalous South China Sea cyclone may be due to more frequent tropical cyclone activity. This is in contrast to the wet August phase, which is associated with anomalous anticyclones in the northern South China Sea and a greater westward extension of the subtropical ridge. JF - Journal of Climate AU - Chang, C-P AU - Zhang, Yongsheng AU - Li, Tim AD - Department of Meteorology, Naval Postgraduate School, Monterey, California Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 4326 EP - 4340 PB - American Meteorological Society, 45 Beacon St. VL - 13 IS - 24 SN - 0894-8755, 0894-8755 KW - Meteorological & Geoastrophysical Abstracts; Water Resources Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Cyclones KW - China, People's Rep., Changjiang R. KW - Rainfall KW - Climatic changes KW - Tropical cyclones KW - Freshwater KW - IS, Tropical Pacific KW - Sea surface temperature anomalies KW - Convergence KW - Ocean-atmosphere system KW - Cyclonic circulation KW - Anticyclones KW - Sea surface temperatures KW - Wind KW - Rivers KW - Monsoon rainfall KW - Marine KW - Weather KW - Summer monsoon KW - Mei-yu front KW - Climates KW - River valleys KW - Surface temperature KW - Baroclinic mode KW - Hurricanes KW - Interannual variability KW - Tropical cyclone activity KW - ISEW, South China Sea KW - Fronts KW - Structure KW - Tropical environment KW - INW, Donghai Sea KW - Monsoons KW - SW 0835:Streamflow and runoff KW - M2 551.58:Climatology (551.58) KW - Q2 09261:General KW - O 2070:Meteorology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20669835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Climate&rft.atitle=Interannual+and+Interdecadal+Variations+of+the+East+Asian+Summer+Monsoon+and+Tropical+Pacific+SSTs.+Part+II%3A+Meridional+Structure+of+the+Monsoon&rft.au=Chang%2C+C-P%3BZhang%2C+Yongsheng%3BLi%2C+Tim&rft.aulast=Chang&rft.aufirst=C-P&rft.date=2000-12-01&rft.volume=13&rft.issue=24&rft.spage=4326&rft.isbn=&rft.btitle=&rft.title=Journal+of+Climate&rft.issn=08948755&rft_id=info:doi/10.1175%2F1520-0442%282000%290132.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hurricanes; Baroclinic mode; Tropical environment; Climatic changes; Ocean-atmosphere system; Anticyclones; River valleys; Surface temperature; Monsoons; Monsoon rainfall; Summer monsoon; Mei-yu front; Tropical cyclones; Interannual variability; Sea surface temperature anomalies; Tropical cyclone activity; Fronts; Convergence; Cyclonic circulation; Sea surface temperatures; Rivers; Cyclones; Weather; Structure; Rainfall; Climates; Wind; China, People's Rep., Changjiang R.; ISEW, South China Sea; INW, Donghai Sea; IS, Tropical Pacific; Marine; Freshwater DO - http://dx.doi.org/10.1175/1520-0442(2000)013<4326:IAIVOT>2.0.CO;2 ER - TY - JOUR T1 - Differential growth of crayfish Procambarus alleni in relation to hydrological conditions in marl prairie wetlands of Everglades National Park, USA AN - 18075466; 5149199 AB - Environmental conditions influence crustacean growth by affecting molt intervals and incremental increases in length and weight. In the seasonally-flooded marl prairie wetlands of eastern Everglades National Park, U.S.A., hydropattern exerts considerable influence on aquatic primary productivity, and so may influence the availability of food resources for higher trophic levels. The seasonal hydroperiod has been drastically altered by anthropogenic factors, but the impacts on the aquatic community are not well known. We studied whether differences in growth of crayfish Procambarus alleni could be detected in habitats with different hydroperiods. We first described growth patterns based on incremental increases in length and weight of crayfish on a high protein diet in the laboratory. Regression analyses indicated that growth patterns in males and females were similar. Although the intermolt period increased with age, the proportional increases in length and weight were similar through successive molts. The relationship between length and weight of crayfish was best described by a power equation for allometric growth. We then compared growth curves for crayfish subpopulations from different areas of the marl prairie. In habitats with the longest hydroperiods, crayfish weight-at-size was not significantly different from that in laboratory crayfish on the high protein diet. However, weight gain per unit increase in length in short hydroperiod sites was significantly less than in long hydroperiod sites or in the laboratory. These results indicate that crayfish productivity may be associated with hydroperiod in these stressed wetlands, and this may contribute to observed source-sink population regulation. JF - Aquatic Ecology AU - Acosta, CA AU - Perry, SA AD - South Florida Natural Resources Center, Everglades National Park, 40001 State Road 9336, Homestead, FL 33034, USA, sue_perry@nps.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 389 EP - 395 VL - 34 IS - 4 SN - 1386-2588, 1386-2588 KW - USA, Florida KW - hydroperiods KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Ecology Abstracts KW - Procambarus alleni KW - Growth rate KW - USA, Florida, Everglades Natl. Park KW - Man-induced effects KW - Food availability KW - Freshwater KW - Molting KW - Environmental factors KW - Growth patterns KW - Growth curves KW - Moulting KW - Hydrology KW - Wetlands KW - Q1 08422:Environmental effects KW - D 04665:Crustaceans KW - Q5 08521:Mechanical and natural changes KW - Q1 08284:Reproduction and development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18075466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+Ecology&rft.atitle=Differential+growth+of+crayfish+Procambarus+alleni+in+relation+to+hydrological+conditions+in+marl+prairie+wetlands+of+Everglades+National+Park%2C+USA&rft.au=Acosta%2C+CA%3BPerry%2C+SA&rft.aulast=Acosta&rft.aufirst=CA&rft.date=2000-12-01&rft.volume=34&rft.issue=4&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Aquatic+Ecology&rft.issn=13862588&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Growth rate; Growth curves; Hydrology; Moulting; Man-induced effects; Wetlands; Food availability; Environmental factors; Molting; Growth patterns; Procambarus alleni; USA, Florida, Everglades Natl. Park; Freshwater ER - TY - JOUR T1 - The response of herbaceous-layer vegetation to anthropogenic disturbance in intermittent stream bottomland forests of southern Indiana, USA AN - 17730288; 4794825 AB - Between 1993 and 1995 we sampled herbaceous layer vegetation on 84 plots in Platanus/Asarum Wet-Mesic Bottomland forests to determine how these forests have responded to human disturbance. Four different disturbance types were sampled (abandoned agricultural are as, clearcuts, group-selection openings, and single-tree selection openings), and uncut 80-100 year-old reference stands were sampled for comparison. Detrended Correspondence Analysis (DCA), distance analyses (chord distance and normalized Euclidean distance) and similarity analysis (Bray-Curtis similarity coefficient) suggest that agricultural use has shifted herbaceous-layer vegetation composition away from that typical of the reference forests, but that clearcutting, group-selection harvest, and single-tree selection harvest have not greatly shifted herbaceous composition. This shift in vegetation on abandoned agricultural land resulted from a loss of indicator species, such as Cardamine concatenata (Michx.) Sw., Stellaria pubera Michx., and Laportea canadensis (L.) Weddell and an influx of disturbance, exotic, and nonforest species (e.g., Lycopodium complanatum L., Lonicera japonica Thunb. and Senecio aureus L.). However, only two species found in reference stands, Erigenia bulbosa (Michx.) Nutt. and Sphenopholis obtusata (Michx.) Scribn., were missing from clearcuts, group-selection openings, and single-tree selection openings. The species richness values of abandoned agriculture, clearcut, and group-selection plots were generally greater than those of single-tree selection and reference plots. Abandoned agricultural areas had much greater total species richness because of the influx of dry-site, exotic, disturbance, and non-forest species. JF - Plant Ecology AU - Jenkins, MA AU - Parker, G R AD - National Park Service, Twin Creeks Natural Resources Center, Great Smoky Mountains National Park, Gatlinburg, TN 37738, USA, mike_jenkins@nps.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 223 EP - 237 PB - Kluwer Academic Publishers VL - 151 IS - 2 SN - 1385-0237, 1385-0237 KW - USA, Indiana KW - Sustainability Science Abstracts; Human Population; Ecology Abstracts KW - Vegetation KW - Forests KW - Disturbance KW - Streams KW - Human impact KW - M1 200:Human Population-Biosphere Interactions KW - D 04700:Management KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17730288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plant+Ecology&rft.atitle=The+response+of+herbaceous-layer+vegetation+to+anthropogenic+disturbance+in+intermittent+stream+bottomland+forests+of+southern+Indiana%2C+USA&rft.au=Jenkins%2C+MA%3BParker%2C+G+R&rft.aulast=Jenkins&rft.aufirst=MA&rft.date=2000-12-01&rft.volume=151&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Plant+Ecology&rft.issn=13850237&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - USA, Indiana; Human impact; Streams; Forests; Vegetation; Disturbance ER - TY - JOUR T1 - Bilateral painful hand-moving fingers: electrophysiological assessment of the central nervous system oscillator. AN - 85361424; pmid-11104217 AB - We describe a 35-year-old woman who presented with the syndrome of painful hand-moving fingers on the right side. Eight months later, she developed similar finger movements and hand discomfort on the left side. She had a history of hand trauma and recurrent shoulder dislocation on the right side. Kinesiologic electromyography suggested a common central oscillator for finger movements in both hands. Electrophysiological assessment of spinal alpha motor neuron excitability, reciprocal inhibition, and Renshaw cell inhibition failed to show any abnormalities. Somatosensory evoked potential test showed marked attenuation of N20 potential recorded from the left somatosensory cortex; paired transcortical magnetic stimulation of the left motor cortex suggested failure of cortical facilitation. The data suggest that the central oscillator responsible for finger movements is located above the spinal cord level in this patient. JF - Movement disorders : official journal of the Movement Disorder Society AU - Jabbari, B AU - Molloy, F M AU - Erickson, M AU - Floeter, M K AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1259 EP - 1263 VL - 15 IS - 6 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Videotape Recording KW - Humans KW - Adult KW - Electroencephalography KW - Electromyography KW - Disease Progression KW - Evoked Potentials, Somatosensory KW - Functional Laterality KW - Female KW - Cerebral Cortex -- physiopathology KW - Fingers -- innervation KW - Pain -- etiology KW - Central Nervous System -- physiopathology KW - Somatosensory Cortex -- physiopathology KW - Movement Disorders -- physiopathology KW - Hand -- innervation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85361424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Bilateral+painful+hand-moving+fingers%3A+electrophysiological+assessment+of+the+central+nervous+system+oscillator.&rft.au=Jabbari%2C+B%3BMolloy%2C+F+M%3BErickson%2C+M%3BFloeter%2C+M+K&rft.aulast=Jabbari&rft.aufirst=B&rft.date=2000-11-01&rft.volume=15&rft.issue=6&rft.spage=1259&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Job stress, upper extremity pain and functional limitations in symptomatic computer users. AN - 72323252; 11025492 AB - Research suggests that exposure to occupational stressors are related to the presence and/or exacerbation of work-related upper extremity symptoms in office workers. Also worker's response to work demands and/or job stressors (i.e., workstyle) may exacerbate symptom severity and impact function. The present study examines the association among work demands, job stress and workstyle on pain and function. 124 symptomatic female office workers completed a questionnaire measuring demographics, medical history, work demands, perception of the work environment, workstyle, pain intensity, functional impact, and time lost from work. Heightened job stress and the tendency to continue to work in a way that contributes to pain to ensure high quality (dimension of workstyle) were related to pain intensity at work and decreased function. These variables, in addition to hours worked per year, were related to increased pain experienced across the work week. The model tested did not predict the occurrence of lost time. The present findings provide support for the association between job stress, workstyle, upper extremity pain and function. While it is not possible to determine the exact direction of the observed relationships, these results are consistent with prior research indicating the potential significance of job stress and workstyle on symptom exacerbation and functional limitations. Implications for evaluation and intervention are discussed. Copyright 2000 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Haufler, A J AU - Feuerstein, M AU - Huang, G D AD - Department of Medical and Clinical Psychology, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 507 EP - 515 VL - 38 IS - 5 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - United States KW - Severity of Illness Index KW - Women, Working KW - Job Satisfaction KW - Humans KW - Adult KW - Activities of Daily Living KW - Middle Aged KW - Arm KW - Female KW - Computer Peripherals KW - Cumulative Trauma Disorders -- complications KW - Pain -- etiology KW - Musculoskeletal Diseases -- physiopathology KW - Cumulative Trauma Disorders -- psychology KW - Computers KW - Stress, Psychological KW - Cumulative Trauma Disorders -- physiopathology KW - Occupational Diseases -- physiopathology KW - Occupational Diseases -- complications KW - Occupational Diseases -- psychology KW - Musculoskeletal Diseases -- psychology KW - Musculoskeletal Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72323252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chemical+hypoxia+induces+MAPK+activation+in+renal+epithelial+cells&rft.au=Sidhu%2C+G+S%3BGoyal%2C+N%3BMaheshwari%2C+R+K&rft.aulast=Sidhu&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modeling recent climate variability in the Arctic Ocean AN - 50157771; 2002-053825 AB - Dramatic changes in the circulation of sea ice and the upper layers of the Arctic Ocean have been reported during the last decade. Similar variability is modeled using a regional, coupled ice-ocean model. Realistic atmospheric forcing fields for 1979-93 are the only interannual signal prescribed in the model. Our results show large-scale changes in sea ice and oceanic conditions when comparing results for the late 1970s / early 1980s and the 1990s. We hypothesize that these changes are in response to even larger scale atmospheric variability in the Northern Hemisphere that can be defined as either the Arctic Oscillation or the North Atlantic Oscillation. Agreement between the direction and scale of change in the model and observations, in the absence of interannual forcing from the global ocean thermohaline circulation, suggests that the atmospheric variability by itself is sufficient to produce basin-scale changes in the Arctic Ocean and sea ice system. JF - Geophysical Research Letters AU - Maslowski, W AU - Newton, B AU - Schlosser, P AU - Semtner, A AU - Martinson, D Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 3743 EP - 3746 PB - American Geophysical Union, Washington, DC VL - 27 IS - 22 SN - 0094-8276, 0094-8276 KW - North Atlantic Oscillation KW - currents KW - ocean circulation KW - annual variations KW - Arctic Oscillation KW - sea ice KW - atmosphere KW - environmental analysis KW - ocean currents KW - climate change KW - modern KW - models KW - ice movement KW - thermohaline circulation KW - ice KW - Arctic Ocean KW - glacial geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50157771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=Modeling+recent+climate+variability+in+the+Arctic+Ocean&rft.au=Maslowski%2C+W%3BNewton%2C+B%3BSchlosser%2C+P%3BSemtner%2C+A%3BMartinson%2C+D&rft.aulast=Maslowski&rft.aufirst=W&rft.date=2000-11-01&rft.volume=27&rft.issue=22&rft.spage=3743&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/10.1029%2F1999GL011227 L2 - http://www.agu.org/journals/gl/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 16 N1 - PubXState - DC N1 - Document feature - illus. incl. geol. sketch maps N1 - Last updated - 2012-06-07 N1 - CODEN - GPRLAJ N1 - SubjectsTermNotLitGenreText - annual variations; Arctic Ocean; Arctic Oscillation; atmosphere; climate change; currents; environmental analysis; glacial geology; ice; ice movement; models; modern; North Atlantic Oscillation; ocean circulation; ocean currents; sea ice; thermohaline circulation DO - http://dx.doi.org/10.1029/1999GL011227 ER - TY - JOUR T1 - Selection on Morphology of Spawning Wild Sockeye Salmon by a Gill-Net Fishery AN - 19924361; 4871855 AB - Human activities can cause artificial selection in wild animals. To examine the effects of gill-net selectivity on locally differentiated populations of sockeye salmon Oncorhynchus nerka in Bristol Bay, Alaska, we completed a three-part study: (1) We showed differentiation in the body form of mature sockeye salmon spawning in beach and stream habitats that were separated by less than 300 m. (2) Because gill-net selection acts directly on the girth of immature sockeye salmon, we correlated girth at capture with the morphological characters distinguishing locally differentiated populations on the spawning grounds. By tagging individual fish and measuring them both when immature and when mature, we found morphology at maturity to be highly correlated with girth during immaturity. (3) Using selection regimes from the fishery catch and escapement data for 1994, we examined the effects of gill-net selectivity on populations of mature adults. We showed that although populations of mixed ocean age-classes may be subject to disruptive selection, single age-class populations are more likely to experience directional selection. The effect of this selection depends on cumulative selection pressures, which probably include natural and sexual selection on this trait. Even so, gill-net selection can be a strong selective force, resulting in significant additional selection on body size and shape within populations. JF - Transactions of the American Fisheries Society AU - Hamon, T R AU - Foote, C J AU - Hilborn, R AU - Rogers, DE AD - Katmai National Park, Post Office Box 7, King Salmon, Alaska 99613, USA, troy_hamon@nps.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1300 EP - 1315 VL - 129 IS - 6 SN - 0002-8487, 0002-8487 KW - Blueback salmon KW - Kokanee KW - Red salmon KW - Sockeye salmon KW - USA, Alaska KW - Sustainability Science Abstracts; Oceanic Abstracts; ASFA Aquaculture Abstracts; Ecology Abstracts; ASFA 1: Biological Sciences & Living Resources; Human Population KW - Resource management KW - Ranching KW - Spawning KW - Habitat KW - Body shape KW - Human impact KW - Fishing KW - Wild spawning KW - Entangling nets KW - INE, USA, Alaska, Bristol Bay KW - Oncorhynchus nerka KW - Fisheries KW - Gear selectivity KW - Body size KW - Selective breeding KW - Population-environment relations KW - Fish culture KW - Selection KW - M1 200:Human Population-Biosphere Interactions KW - D 04700:Management KW - M3 1010:Issues in Sustainable Development KW - Q3 08582:Fish culture KW - O 5020:Fisheries and Fishery Biology KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19924361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+the+American+Fisheries+Society&rft.atitle=Selection+on+Morphology+of+Spawning+Wild+Sockeye+Salmon+by+a+Gill-Net+Fishery&rft.au=Hamon%2C+T+R%3BFoote%2C+C+J%3BHilborn%2C+R%3BRogers%2C+DE&rft.aulast=Hamon&rft.aufirst=T&rft.date=2000-11-01&rft.volume=129&rft.issue=6&rft.spage=1300&rft.isbn=&rft.btitle=&rft.title=Transactions+of+the+American+Fisheries+Society&rft.issn=00028487&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2001-05-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Wild spawning; Entangling nets; Body size; Gear selectivity; Ranching; Selective breeding; Body shape; Fish culture; Fishing; Resource management; Fisheries; Population-environment relations; Spawning; Habitat; Selection; Human impact; Oncorhynchus nerka; INE, USA, Alaska, Bristol Bay ER - TY - JOUR T1 - WOLF-BISON INTERACTIONS IN YELLOWSTONE NATIONAL PARK AN - 19336582; 8696703 AB - We studied interactions of reintroduced wolves (Canis lupus) with bison (Bison bison) in Yellowstone National Park. Only 2 of 41 wolves in this study had been exposed to bison before their translocation. Wolves were more successful killing elk (Cervus elaphus) than bison, and elk were more abundant than bison, so elk were the primary prey of wolves. Except for a lone emaciated bison calf killed by 8 1-year-old wolves 21 days after their release, the 1st documented kill occurred 25 months after wolves were released. Fourteen bison kills were documented from April 1995 through March 1999. All kills were made in late winter when bison were vulnerable because of poor condition or of bison that were injured or young. Wolves learned to kill bison and killed more bison where elk were absent or scarce. We predict that wolves that have learned to kill bison will kill them more regularly, at least in spring. The results of this study indicate how adaptable wolves are at killing prey species new to them. JF - Journal of Mammalogy AU - Smith, Douglas W AU - Mech, LDavid AU - Meagher, Mary AU - Clark, Wendy E AU - Jaffe, Rosemary AU - Phillips, Michael K AU - Mack, John A AD - Yellowstone Center for Resources, P.O. Box 168, Yellowstone National Park, WY 82190 (DWS, WEC, MKP, JAM), doug_smith@nps.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1128 EP - 1135 PB - Allen Press, Inc., 810 East Tenth St. VL - 81 IS - 4 SN - 0022-2372, 0022-2372 KW - Animal Behavior Abstracts; Ecology Abstracts KW - Bison bison KW - Canis lupus KW - Cervus elaphus KW - Yellowstone National Park KW - mortality KW - predation KW - restoration KW - wolf KW - Bison KW - National parks KW - Bison bison bison KW - Translocation KW - Prey KW - Y 25150:General/Miscellaneous KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19336582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Mammalogy&rft.atitle=WOLF-BISON+INTERACTIONS+IN+YELLOWSTONE+NATIONAL+PARK&rft.au=Smith%2C+Douglas+W%3BMech%2C+LDavid%3BMeagher%2C+Mary%3BClark%2C+Wendy+E%3BJaffe%2C+Rosemary%3BPhillips%2C+Michael+K%3BMack%2C+John+A&rft.aulast=Smith&rft.aufirst=Douglas&rft.date=2000-11-01&rft.volume=81&rft.issue=4&rft.spage=1128&rft.isbn=&rft.btitle=&rft.title=Journal+of+Mammalogy&rft.issn=00222372&rft_id=info:doi/10.1644%2F1545-1542%282000%290812.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - National parks; Translocation; Prey; Cervus elaphus; Bison; Bison bison bison; Canis lupus DO - http://dx.doi.org/10.1644/1545-1542(2000)081<1128:WBIIYN>2.0.CO;2 ER - TY - JOUR T1 - Serodiagnosis of Bartonella bacilliformis Infection by Indirect Fluorescence Antibody Assay: Test Development and Application to a Population in an Area of Bartonellosis Endemicity AN - 18015503; 4869670 AB - Bartonella bacilliformis causes bartonellosis, a potentially life-threatening emerging infectious disease seen in the Andes Mountains of South America. There are no generally accepted serologic tests to confirm the disease. We developed an indirect fluorescence antibody (IFA) test for the detection of antibodies to B. bacilliformis and then tested its performance as an aid in the diagnosis of acute bartonellosis. The IFA is 82% sensitive in detecting B. bacilliformis antibodies in acute-phase blood samples of laboratory-confirmed bartonellosis patients. When used to examine convalescent-phase sera, the IFA is positive in 93% of bartonellosis cases. The positive predictive value of the test is 89% in an area of Peru where B. bacilliformis is endemic and where the point prevalence of infection is 45%. JF - Journal of Clinical Microbiology AU - Chamberlin, J AU - Laughlin, L AU - Gordon, S AU - Romero, S AU - Solorzano, N AU - Regnery, R L AD - Uniformed Services University of the Health Sciences, Department of Preventive Medicine, Division of Tropical Public Health, Rm. A3085, 4301 Jones Bridge Rd., Bethesda, MD 20814, drdj@erols.com Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 4269 EP - 4271 VL - 38 IS - 11 SN - 0095-1137, 0095-1137 KW - serodiagnosis KW - Microbiology Abstracts B: Bacteriology KW - Indirect fluorescent antibody test KW - South America KW - Bartonella bacilliformis KW - Immunoassays KW - Bartonellosis KW - J 02831:Techniques and reagents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18015503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Serodiagnosis+of+Bartonella+bacilliformis+Infection+by+Indirect+Fluorescence+Antibody+Assay%3A+Test+Development+and+Application+to+a+Population+in+an+Area+of+Bartonellosis+Endemicity&rft.au=Chamberlin%2C+J%3BLaughlin%2C+L%3BGordon%2C+S%3BRomero%2C+S%3BSolorzano%2C+N%3BRegnery%2C+R+L&rft.aulast=Chamberlin&rft.aufirst=J&rft.date=2000-11-01&rft.volume=38&rft.issue=11&rft.spage=4269&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bartonella bacilliformis; South America; Indirect fluorescent antibody test; Bartonellosis; Immunoassays ER - TY - JOUR T1 - Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. AN - 72314209; 11020217 AB - Fibroblast growth factor 2 (FGF2) is an excellent candidate to regulate remyelination based on its proposed actions in oligodendrocyte lineage cell development in conjunction with its involvement in CNS regeneration. To assess the potential for FGF2 to play a role in remyelination, we examined the expression pattern of FGF2 and FGF receptors (FGFRs) in an experimental demyelinating disease with extensive remyelination. Adult mice were intracranially injected with murine hepatitis virus strain A-59 (MHV-A59) to induce focally demyelinated spinal cord lesions that spontaneously remyelinate, with corresponding recovery of motor function. Using kinetic RT-PCR analysis of spinal cord RNA, we found significantly increased levels of FGF2 mRNA transcripts, which peaked during the initial stage of remyelination. Analysis of tissue sections demonstrated that increased levels of FGF2 mRNA and protein were localized within demyelinated regions of white matter, including high FGF2 expression associated with astrocytes. The expression of corresponding FGF receptors was significantly increased in lesion areas during the initial stage of remyelination. In normal and lesioned white matter, oligodendrocyte lineage cells, including progenitors and mature cells, were found to express multiple FGFR types (FGFR1, FGFR2, and/or FGFR3). In addition, in lesion areas, astrocytes expressed FGFR1, FGFR2, and FGFR3. These findings indicate that, during remyelination, FGF2 may play a role in directly regulating oligodendrocyte lineage cell responses and may also act through paracrine or autocrine effects on astrocytes, which are known to synthesize other growth factors and immunoregulatory molecules that influence oligodendrocyte lineage cells. JF - Journal of neuroscience research AU - Messersmith, D J AU - Murtie, J C AU - Le, T Q AU - Frost, E E AU - Armstrong, R C AD - Department of Anatomy and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 2000/10/15/ PY - 2000 DA - 2000 Oct 15 SP - 241 EP - 256 VL - 62 IS - 2 SN - 0360-4012, 0360-4012 KW - RNA, Messenger KW - 0 KW - Receptors, Fibroblast Growth Factor KW - Fibroblast Growth Factor 2 KW - 103107-01-3 KW - Index Medicus KW - Animals KW - Multiple Sclerosis -- metabolism KW - Hepatitis, Viral, Animal KW - RNA, Messenger -- metabolism KW - Coronavirus KW - Mice, Inbred C57BL KW - Motor Skills Disorders -- chemically induced KW - Mice KW - Female KW - Neuroglia -- metabolism KW - Fibroblast Growth Factor 2 -- metabolism KW - Receptors, Fibroblast Growth Factor -- metabolism KW - Myelin Sheath -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72314209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=Fibroblast+growth+factor+2+%28FGF2%29+and+FGF+receptor+expression+in+an+experimental+demyelinating+disease+with+extensive+remyelination.&rft.au=Messersmith%2C+D+J%3BMurtie%2C+J+C%3BLe%2C+T+Q%3BFrost%2C+E+E%3BArmstrong%2C+R+C&rft.aulast=Messersmith&rft.aufirst=D&rft.date=2000-10-15&rft.volume=62&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-15 N1 - Date created - 2000-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-Term Potentiation in the Presence of NMDA Receptor Antagonist Arylalkylamine Spider Toxins AN - 17703272; 4779943 AB - The role of the NMDA receptor (NMDAR) in long-term potentiation (LTP) is now well established. All potent NMDAR antagonists known to date inhibit the induction of LTP at the Schaffer collateral-CA1 pyramidal cell synapse in rat hippocampus, regardless of their site and mechanism of action. Arylalkylamine toxins are noncompetitive NMDAR antagonists in the mammalian central nervous system (CNS). The synthetic toxins argiotoxin-636 (Arg-636), Joro spider toxin (JSTX-3), alpha -agatoxin-489 and -505 (Agel-489 and Agel-505) and philanthotoxin-433 ( delta -PhTX) were found in the present study to have no effect on the induction of LTP in the Schaffer collateral-CA1 pyramidal cell pathway in rat hippocampal slices maintained in vitro. Arylalkylamine toxins represent a class of potent NMDAR antagonists that fail to affect hippocampal LTP, and thus provide novel structural leads for the development of NMDAR antagonists that do not impair cognition. JF - Journal of Neuroscience Research AU - Albensi, B C AU - Alasti, N AU - Mueller, AL AD - NPS Pharmaceuticals, Inc., 420 Chipeta Way, Salt Lake City, UT 84108, USA Y1 - 2000/10/15/ PY - 2000 DA - 2000 Oct 15 SP - 177 EP - 185 VL - 62 IS - 2 SN - 0360-4012, 0360-4012 KW - Araneae KW - rats KW - Spiders KW - Entomology Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Synapses KW - N-Methyl-D-aspartic acid receptors KW - Drug development KW - Toxins KW - Cognitive ability KW - Long-term potentiation KW - Venom KW - X 24173:Animals KW - Z 05183:Toxicology & resistance KW - N3 11091:Vertebrate Nervous Systems: General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17703272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience+Research&rft.atitle=Long-Term+Potentiation+in+the+Presence+of+NMDA+Receptor+Antagonist+Arylalkylamine+Spider+Toxins&rft.au=Albensi%2C+B+C%3BAlasti%2C+N%3BMueller%2C+AL&rft.aulast=Albensi&rft.aufirst=B&rft.date=2000-10-15&rft.volume=62&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience+Research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Araneae; N-Methyl-D-aspartic acid receptors; Toxins; Venom; Synapses; Long-term potentiation; Cognitive ability; Drug development ER - TY - JOUR T1 - Parallel climate model (PCM) control and transient simulations AN - 899155278; 15625348 AB - The Department of Energy (DOE) supported Parallel Climate Model (PCM) makes use of the NCAR Community Climate Model (CCM3) and Land Surface Model (LSM) for the atmospheric and land surface components, respectively, the DOE Los Alamos National Laboratory Parallel Ocean Program (POP) for the ocean component, and the Naval Postgraduate School sea-ice model. The PCM executes on several distributed and shared memory computer systems. The coupling method is similar to that used in the NCAR Climate System Model (CSM) in that a flux coupler ties the components together, with interpolations between the different grids of the component models. Flux adjustments are not used in the PCM. The ocean component has 2/3 degree average horizontal grid spacing with 32 vertical levels and a free surface that allows calculation of sea level changes. Near the equator, the grid spacing is approximately 1/2 degree in latitude to better capture the ocean equatorial dynamics. The North Pole is rotated over northern North America thus producing resolution smaller than 2/3 degree in the North Atlantic where the sinking part of the world conveyor circulation largely takes place. Because this ocean model component does not have a computational point at the North Pole, the Arctic Ocean circulation systems are more realistic and similar to the observed. The elastic viscous plastic sea ice model has a grid spacing of 27km to represent small-scale features such as ice transport through the Canadian Archipelago and the East Greenland current region. Results from a 300year present-day coupled climate control simulation are presented, as well as for a transient 1% per year compound CO sub(2) increase experiment which shows a global warming of 1.27 degree C for a 10year average at the doubling point of CO sub(2) and 2.89 degree C at the quadrupling point. There is a gradual warming beyond the doubling and quadrupling points with CO sub(2) held constant. Globally averaged sea level rise at the time of CO sub(2) doubling is approximately 7cm and at the time of quadrupling it is 23cm. Some of the regional sea level changes are larger and reflect the adjustments in the temperature, salinity, internal ocean dynamics, surface heat flux, and wind stress on the ocean. A 0.5% per year CO sub(2) increase experiment also was performed showing a global warming of 1.5 degree C around the time of CO sub(2) doubling and a similar warming pattern to the 1% CO sub(2) per year increase experiment. El Nino and La Nina events in the tropical Pacific show approximately the observed frequency distribution and amplitude, which leads to near observed levels of variability on interannual time scales. JF - Climate Dynamics AU - Washington, WM AU - Weatherly, J W AU - Meehl, G A AU - Semtner Jr, AJ AU - Bettge, T W AU - Craig AU - Strand, WG Jr AU - Arblaster, J AU - Wayland, V B AU - James, R AU - Zhang, Y AD - US Naval Postgraduate School (NPS), USA, US Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 755 EP - 774 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 16 IS - 10-11 SN - 0930-7575, 0930-7575 KW - Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts KW - Ocean models KW - Climate change KW - USA, New Mexico, Los Alamos KW - IS, Tropical Pacific KW - El Nino KW - Climate control KW - Ocean-atmosphere system KW - Ice drift KW - PN, Arctic, North Pole KW - Marine KW - PN, Arctic Ocean KW - Climate models KW - Temperature KW - Simulation KW - Stress KW - Archipelagoes KW - Greenhouse effect KW - AN, North Atlantic KW - ANE, Atlantic, East Greenland Current KW - sea level changes KW - Heat flux over oceans KW - Interannual variability KW - Sea ice KW - Numerical simulations KW - Oceans KW - Global warming KW - Carbon dioxide KW - Sea level changes KW - O 2010:Physical Oceanography KW - M3 1010:Issues in Sustainable Development KW - M2 551.326:Floating Ice (551.326) KW - Q2 09244:Air-sea coupling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899155278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Climate+Dynamics&rft.atitle=Parallel+climate+model+%28PCM%29+control+and+transient+simulations&rft.au=Washington%2C+WM%3BWeatherly%2C+J+W%3BMeehl%2C+G+A%3BSemtner+Jr%2C+AJ%3BBettge%2C+T+W%3BCraig%3BStrand%2C+WG+Jr%3BArblaster%2C+J%3BWayland%2C+V+B%3BJames%2C+R%3BZhang%2C+Y&rft.aulast=Washington&rft.aufirst=WM&rft.date=2000-10-01&rft.volume=16&rft.issue=10-11&rft.spage=755&rft.isbn=&rft.btitle=&rft.title=Climate+Dynamics&rft.issn=09307575&rft_id=info:doi/10.1007%2Fs003820000079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Sea ice; El Nino; Climate change; Ice drift; Ocean-atmosphere system; Archipelagoes; Greenhouse effect; Carbon dioxide; Sea level changes; Heat flux over oceans; Interannual variability; Climate models; Numerical simulations; Ocean models; Climate control; Global warming; sea level changes; Oceans; Temperature; Stress; Simulation; PN, Arctic Ocean; USA, New Mexico, Los Alamos; AN, North Atlantic; PN, Arctic, North Pole; IS, Tropical Pacific; ANE, Atlantic, East Greenland Current; Marine DO - http://dx.doi.org/10.1007/s003820000079 ER - TY - JOUR T1 - Compressibility effects on steady streaming from a noncompact rigid sphere. AN - 85354945; pmid-11051478 AB - The problem of steady streaming around a rigid isolated sphere in a plane standing acoustic field is considered. Existing results in the literature have been generalized to allow for noncompactness of the sphere, and the influence of fluid compressibility on the streaming behavior has been included. It is found that in the high-frequency limit of interest for which the streaming is strongest, the effective steady slip velocity at the edge of the inner boundary layer region that is responsible for driving the steady streaming in the bulk of the fluid in the outer region, has a complex variation over the surface of the sphere that depends on (i) the sphere position (with respect to the node/antinode of the acoustic field), (ii) the extent of sphere compactness, and (iii) on a well-defined function (representing compressibility effects) of the fluid Prandtl number and its ratio of specific heats. Not surprisingly, the contribution from this function is negligible when the host fluid is a liquid. The steady streaming behavior around the sphere is demonstrated with the help of flow streamlines for various cases in the diffusive limit of weak outer flow for low streaming Reynolds numbers. JF - The Journal of the Acoustical Society of America AU - Gopinath, A AU - Trinh, E H AD - Department of Mechanical Engineering, Naval Postgraduate School, Monterey, California 93943, USA. gopinath@nps.navy.mil Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 1514 EP - 1520 VL - 108 IS - 4 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Nonlinear Dynamics KW - Acoustics KW - Ultrasonics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85354945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Compressibility+effects+on+steady+streaming+from+a+noncompact+rigid+sphere.&rft.au=Gopinath%2C+A%3BTrinh%2C+E+H&rft.aulast=Gopinath&rft.aufirst=A&rft.date=2000-10-01&rft.volume=108&rft.issue=4&rft.spage=1514&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Common myths about electrosurgery. AN - 85351561; pmid-11020184 AB - The electrosurgery device market is lucrative and highly competitive. Several device manufacturers exist, and many creative techniques are used to differentiate products. Some device manufacturers make claims in marketing campaigns that are difficult to reconcile with the laws of physics or basic physiology. The variety of claims may be confusing to surgeons desiring to purchase new electrosurgical products. Understanding a few basic principles of electrosurgery physics can allow a surgeon to be a more informed consumer of electrosurgical products. This article discusses the basic physics of electrosurgery and then addresses several common misconceptions about electrosurgery and electrosurgical devices. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Zinder, D J AD - Naval Postgraduate School, US Navy, Monterey, CA 93943-2791, USA. Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 450 EP - 455 VL - 123 IS - 4 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Sensitivity and Specificity KW - Equipment Design KW - Humans KW - Electrosurgery -- methods KW - Electrosurgery -- instrumentation KW - Terminology as Topic KW - Head and Neck Neoplasms -- surgery KW - Female KW - Male KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85351561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Common+myths+about+electrosurgery.&rft.au=Zinder%2C+D+J&rft.aulast=Zinder&rft.aufirst=D&rft.date=2000-10-01&rft.volume=123&rft.issue=4&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - A home program of rehabilitation for moderately severe traumatic brain injury patients. The DVHIP Study Group. AN - 85345878; pmid-10970930 AB - We have recently reported the results of a prospective controlled randomized trial comparing home versus inpatient cognitive rehabilitation for patients with moderate to severe head injury. That study showed no overall difference in outcomes between the two groups.(1) In this article, we provide further details of the home program arm of the study. All patients in the home program received medical treatment as needed, a multidisciplinary in-hospital evaluation, and TBI counseling before entering the eight-week home program, which then included guidance on home activities, as well as weekly telephone calls from a psychiatric nurse. JF - The Journal of head trauma rehabilitation AU - Warden, D L AU - Salazar, A M AU - Martin, E M AU - Schwab, K A AU - Coyle, M AU - Walter, J AD - Uniformed Services University of the Health Sciences, Walter Reed AMC, Defense and Veterans Head Injury Program at Walter Reed AMC, Washington, DC, USA. Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 1092 EP - 1102 VL - 15 IS - 5 SN - 0885-9701, 0885-9701 KW - Index Medicus KW - National Library of Medicine KW - Telephone KW - Humans KW - Recovery of Function KW - Activities of Daily Living KW - Counseling KW - Problem Solving KW - Cognition -- physiology KW - Prospective Studies KW - Patient Care Team KW - Hospitalization KW - Patient Compliance KW - Adaptation, Psychological KW - Adult KW - Treatment Outcome KW - Follow-Up Studies KW - Psychiatric Nursing KW - Adolescent KW - Male KW - Female KW - Military Personnel KW - Brain Injuries -- rehabilitation KW - Home Care Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85345878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+head+trauma+rehabilitation&rft.atitle=A+home+program+of+rehabilitation+for+moderately+severe+traumatic+brain+injury+patients.+The+DVHIP+Study+Group.&rft.au=Warden%2C+D+L%3BSalazar%2C+A+M%3BMartin%2C+E+M%3BSchwab%2C+K+A%3BCoyle%2C+M%3BWalter%2C+J&rft.aulast=Warden&rft.aufirst=D&rft.date=2000-10-01&rft.volume=15&rft.issue=5&rft.spage=1092&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+head+trauma+rehabilitation&rft.issn=08859701&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - SuppNotes - Comment In: J Head Trauma Rehabil. 2001 Feb;16(1):vii-ix[11324582] N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Opportunities for neuroprotection in traumatic brain injury. AN - 85344647; pmid-10970935 AB - Traumatic injury of the brain in man is normally followed by little or no recovery of function by the lesioned tissue. Neuroprotective strategies employed in the acute period after traumatic CNS injury attempt to use pharmacological tools to reduce the progressive secondary injury processes that follow after the initial lesion occurs to limit overall tissue damage. Results from experimental animal studies using a variety of drugs that modulate neurotransmitter function, scavenge free radicals, or interfere with cell death cascades point toward many new opportunities for pharmacological intervention in the acute and subacute period after traumatic brain injury. JF - The Journal of head trauma rehabilitation AU - Verma, A AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 1149 EP - 1161 VL - 15 IS - 5 SN - 0885-9701, 0885-9701 KW - Index Medicus KW - National Library of Medicine KW - Acute Disease KW - Animals KW - Brain Injuries -- physiopathology KW - Neurotransmitter Agents -- physiology KW - Humans KW - Brain -- drug effects KW - Recovery of Function -- physiology KW - Cell Death -- drug effects KW - Spinal Cord Injuries -- physiopathology KW - Brain -- physiopathology KW - Brain Injuries -- therapy KW - Spinal Cord Injuries -- therapy KW - Free Radical Scavengers -- therapeutic use KW - Neurotransmitter Agents -- antagonists & inhibitors KW - Energy Metabolism -- drug effects KW - Apoptosis -- drug effects KW - Neuroprotective Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85344647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+head+trauma+rehabilitation&rft.atitle=Opportunities+for+neuroprotection+in+traumatic+brain+injury.&rft.au=Verma%2C+A&rft.aulast=Verma&rft.aufirst=A&rft.date=2000-10-01&rft.volume=15&rft.issue=5&rft.spage=1149&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+head+trauma+rehabilitation&rft.issn=08859701&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Palestine after Arafat AN - 60580616; 200112284 AB - Yasir Arafat has no son or groomed successor. The challenge is not to gaze into a crystal ball & guess which individual or individuals will succeed him, but to identify the key factors affecting Palestinian succession, of which six are described. Adapted from the source document. JF - Washington Quarterly AU - Robinson, Glenn E AD - Naval Postgraduate School Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 77 EP - 90 VL - 23 IS - 4 SN - 0163-660X, 0163-660X KW - Palestinians KW - Presidents KW - Inheritance and Succession KW - Leadership KW - article KW - 9085: government/political systems; national governments/political systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60580616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Washington+Quarterly&rft.atitle=Palestine+after+Arafat&rft.au=Robinson%2C+Glenn+E&rft.aulast=Robinson&rft.aufirst=Glenn&rft.date=2000-10-01&rft.volume=23&rft.issue=4&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Washington+Quarterly&rft.issn=0163660X&rft_id=info:doi/ LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Palestinians; Inheritance and Succession; Presidents; Leadership ER - TY - JOUR T1 - The RMA and the Interagency: Knowledge and Speed vs. Ignorance and Sloth? AN - 60145144; 200216348 AB - Addresses the problem of interagency coordination that a revolution in military affairs (RMA) must resolve if it is to be effective as well as revolutionary. Interagency trouble spots as well as strengths are identified; structural, decision-making, & policy-making processes are described; & areas for future study & coordination improvement are proposed. 1 Figure. K. Coddon JF - Parameters: U.S. Army War College Quarterly AU - Tucker, David AD - Special Operations Academic Group, Naval Postgraduate School Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 66 EP - 76 VL - 30 IS - 3 SN - 0031-1723, 0031-1723 KW - military doctrines KW - Policy Making KW - Coordination KW - Government Agencies KW - United States of America KW - Organizational Change KW - Armed Forces KW - Interorganizational Relations KW - article KW - 9091: government/political systems; armed forces UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60145144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Parameters%3A+U.S.+Army+War+College+Quarterly&rft.atitle=The+RMA+and+the+Interagency%3A+Knowledge+and+Speed+vs.+Ignorance+and+Sloth%3F&rft.au=Tucker%2C+David&rft.aulast=Tucker&rft.aufirst=David&rft.date=2000-10-01&rft.volume=30&rft.issue=3&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Parameters%3A+U.S.+Army+War+College+Quarterly&rft.issn=00311723&rft_id=info:doi/ LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Armed Forces; Interorganizational Relations; Policy Making; Organizational Change; United States of America; Coordination; Government Agencies ER - TY - JOUR T1 - Crafting Civilian Control in Emerging Democracies: Argentina and Venezuela AN - 60128406; 200112454 AB - Democratic transitions create an opportunity for elected officials to maximize their leverage over the armed forces & create institutions that permanently shift power away from the military. This article develops a theoretical argument about how civilian control is established. Venezuela institutionalized weak civilian control in the wake of its 1958 democratic transition, allowing the regime to survive the 1992 coup attempts. Argentina moved close to strong civilian control by 1995, although such control is exercised through questionable institutional channels. 5 Figures, 53 References. Adapted from the source document. JF - Journal of Interamerican Studies and World Affairs AU - Trinkunas, Harold A AD - Dept National Security Affairs, Naval Postgraduate School Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 77 EP - 109 VL - 42 IS - 3 SN - 0022-1937, 0022-1937 KW - Argentina KW - Venezuela KW - Democracy KW - Armed Forces KW - Military Civilian Relations KW - article KW - 9091: government/political systems; armed forces UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60128406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interamerican+Studies+and+World+Affairs&rft.atitle=Crafting+Civilian+Control+in+Emerging+Democracies%3A+Argentina+and+Venezuela&rft.au=Trinkunas%2C+Harold+A&rft.aulast=Trinkunas&rft.aufirst=Harold&rft.date=2000-10-01&rft.volume=42&rft.issue=3&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interamerican+Studies+and+World+Affairs&rft.issn=00221937&rft_id=info:doi/ LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Democracy; Venezuela; Armed Forces; Military Civilian Relations; Argentina ER - TY - JOUR T1 - Cytotoxic necrotizing factor type 1 of uropathogenic Escherichia coli kills cultured human uroepithelial 5637 cells by an apoptotic mechanism AN - 17705187; 4783879 AB - Pathogenic Escherichia coli associated with urinary tract infections (UTIs) in otherwise healthy individuals frequently produce cytotoxic necrotizing factor type 1 (CNF1), a member of the family of bacterial toxins that target the Rho family of small GTP-binding proteins. To gain insight into the function of CNF1 in the development of E. coli-mediated UTIs, we examined the effects of CNF1 intoxication on a panel of human cell lines derived from physiologically relevant sites (bladder, ureters, and kidneys). We identified one uroepithelial cell line that exhibited a distinctly different CNF1 intoxication phenotype from the prototypic one of multinucleation without cell death that is seen when HEp-2 or other epithelial cells are treated with CNF1. The 5637 bladder cell line detached from the growth surface within 72 h of CNF1 intoxication, a finding that suggested frank cytotoxicity. To determine the basis for the unexpected toxic effect of CNF1 on 5637 cells, we compared the degree of toxin binding, actin fiber formation, and Rho modification with those CNF1-induced events in HEp-2 cells. We found no apparent difference in the amount of CNF1 bound to 5637 cells and HEp-2 cells. Moreover, CNF1 modified Rho, in vivo and in vitro, in both cell types. In contrast, one of the classic responses to CNF1 in HEp-2 and other epithelial cell lines, the formation of actin stress fibers, was markedly absent in 5637 cells. Indeed, actin stress fiber induction by CNF1 did not occur in any of the other human bladder cell lines that we tested (J82, SV-HUC-1, or T24). Furthermore, the appearance of lamellipodia and filopodia in 5637 cells suggested that CNF1 activated the Cdc42 and Rac proteins. Finally, apoptosis was observed in CNF1-intoxicated 5637 cells. If our results with 5637 cells reflect the interaction of CNF1 with the transitional uroepithelium in the human bladder, then CNF1 may be involved in the exfoliative process that occurs in that organ after infection with uropathogenic E. coli. JF - Infection and Immunity AU - Mills, M AU - Meysick, K C AU - O'Brien, AD AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA, aobrien@usuhs.mil Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 5869 EP - 5880 VL - 68 IS - 10 SN - 0019-9567, 0019-9567 KW - man KW - cell culture KW - Cdc42 protein KW - Cytotoxic necrotizing factor 1 KW - Rac protein KW - cytotoxic necrotizing factor 1 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Cell death KW - Apoptosis KW - Urinary bladder KW - Cytotoxic factors KW - Escherichia coli KW - Epithelium KW - Actin KW - Urinary tract KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17705187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Cytotoxic+necrotizing+factor+type+1+of+uropathogenic+Escherichia+coli+kills+cultured+human+uroepithelial+5637+cells+by+an+apoptotic+mechanism&rft.au=Mills%2C+M%3BMeysick%2C+K+C%3BO%27Brien%2C+AD&rft.aulast=Mills&rft.aufirst=M&rft.date=2000-10-01&rft.volume=68&rft.issue=10&rft.spage=5869&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Actin; Apoptosis; Urinary bladder; Epithelium; Cytotoxic factors; Urinary tract; Cell death ER - TY - JOUR T1 - Response to Stever and Garrison AN - 60565465; 200101254 AB - A response to James A. Stever's "The Parallel Universes: Pragmatism and Public Administration" & Jim Garrison's "Pragmatism and Public Administration" (both, 2000). Although differences between the author's & Karen G. Evans's (both, 2000) treatments of the relationship between public administration & pragmatism are noted, it is contended that the two articles should be viewed as complementary, not contrasting. Differences between Stever's & the author's definitions of the term "traditionalist" are discussed; specifically, Stever's assertion that the early public administration scholars were influenced by the pragmatist thought of John Dewey is rejected. In addition, Stever's claim that public administration officials have actively engaged pragmatist thinking is repudiated. Garrison's statement that he would be satisfied if current professionals adopted only a few of pragmatism's tenets is criticized & contrasted with earlier pragmatist theorists who attempted to create a comprehensive system of thought. 8 References. J. W. Parker JF - Administration & Society AU - Snider, Keith F AD - Dept Systems Management, Naval Postgraduate School, Monterey, CA Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 487 EP - 489 VL - 32 IS - 4 SN - 0095-3997, 0095-3997 KW - Theoretical Problems KW - Pragmatism KW - Public Administration KW - Dewey, John KW - article KW - 9263: public policy/administration; public administration/bureaucracy KW - 9003: history and theory; political theories and philosophy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60565465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+%26+Society&rft.atitle=Response+to+Stever+and+Garrison&rft.au=Snider%2C+Keith+F&rft.aulast=Snider&rft.aufirst=Keith&rft.date=2000-09-01&rft.volume=32&rft.issue=4&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Administration+%26+Society&rft.issn=00953997&rft_id=info:doi/ LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ADSODM N1 - SubjectsTermNotLitGenreText - Public Administration; Pragmatism; Dewey, John; Theoretical Problems ER - TY - JOUR T1 - Iran and Weapons of Mass Destruction AN - 59941782; 200513588 AB - This article surveys Iran's efforts to develop Weapons of Mass Destruction, its motives for doing so, & the threat this poses to other regional states. The article discusses how the United States & others have tried to prevent or delay the deployment of such systems, as well as possible actions for U.S. policy to reduce the potential problems arising from their presence in Iran's arsenal. Adapted from the source document. JF - MERIA: Middle East Review of International Affairs AU - Carus, W Seth AD - Center Counterproliferation Research, National Defense University, Washington, DC Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 57 EP - 67 VL - 4 IS - 3 SN - 1565-8996, 1565-8996 KW - Weapons of Mass Destruction KW - Nuclear Proliferation KW - Iran KW - Weapons KW - Motivation KW - United States of America KW - Threat KW - article KW - 9063: international relations; international relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59941782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MERIA%3A+Middle+East+Review+of+International+Affairs&rft.atitle=Iran+and+Weapons+of+Mass+Destruction&rft.au=Carus%2C+W+Seth&rft.aulast=Carus&rft.aufirst=W&rft.date=2000-09-01&rft.volume=4&rft.issue=3&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=MERIA%3A+Middle+East+Review+of+International+Affairs&rft.issn=15658996&rft_id=info:doi/ L2 - http://meria.idc.ac.il/ LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2009-06-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Iran; Weapons; Nuclear Proliferation; Threat; United States of America; Motivation ER - TY - JOUR T1 - Eye Injuries in the U.S. Armed Forces AN - 17851547; 4883878 AB - To develop prevention and treatment modalities for eye injuries, ophthalmologists require epidemiological data on the various types of eye injuries. This study sought to define eye injury patterns in the U.S. armed forces. Data on patterns of eye injury in the armed forces were obtained through voluntary reporting by U.S. military ophthalmologists throughout the world. The reporting format was standardized with the U.S. Eye Injury Registry initial and follow-up report forms. The data were analyzed for significant injury patterns. Data on 112 patients were submitted, representing a broad range of the military population. Data on a total of 96 patients with a 6-month follow-up were analyzed in this study. Immediately after injury, 43% of the patients were noted to have poor vision (worse than 20/200). After treatment, only 20% were noted to have poor vision. Patients lost an average of 21.6 days of work after a severe eye injury. An eye injury is a traumatic and potentially debilitating event. The loss of visual acuity can be drastic, resulting in an extensive recovery period. JF - Military Medicine AU - Lau, J S AU - Thach, AB AU - Burden, J H AU - Ward, T P AU - Hshieh, P B AU - Hollifield, R D AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 683 EP - 686 VL - 165 IS - 9 SN - 0026-4075, 0026-4075 KW - USA KW - Health & Safety Science Abstracts KW - Injuries KW - Eye KW - Military KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17851547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Medicine&rft.atitle=Eye+Injuries+in+the+U.S.+Armed+Forces&rft.au=Lau%2C+J+S%3BThach%2C+AB%3BBurden%2C+J+H%3BWard%2C+T+P%3BHshieh%2C+P+B%3BHollifield%2C+R+D&rft.aulast=Lau&rft.aufirst=J&rft.date=2000-09-01&rft.volume=165&rft.issue=9&rft.spage=683&rft.isbn=&rft.btitle=&rft.title=Military+Medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Military; Occupational exposure; Eye; Injuries ER - TY - JOUR T1 - Ionizing Radiation and Bacterial Challenge Alter Splenic Cytokine Gene Expression AN - 17829791; 4854949 AB - Irradiation increases susceptibility to bacterial infection. Exogenous proinflammatory cytokines can alter the response of mice to gamma radiation, but the role of endogenous inflammatory cytokines after bacterial infection in irradiated animals is not known. Gene expression of hematopoietic (GM-CSF) and proinflammatory (IL-1 beta , IL-6 and TNF- alpha ) cytokines were examined in spleens of B6D2F1/J female mice after irradiation alone (1.0- and 7.0-Gy), and after irradiation followed by Klebsiella pneumoniae s.c. challenge 4 days postirradiation by using the reverse transcription-polymerase chain reaction (RT-PCR) and Southern blot hybridization. At 4, 8, and 24 h after bacterial challenge in 7.0-Gy-irradiated mice, GM-CSF mRNA increased (p < 0.05). TNF- alpha mRNA in irradiated mice were slightly decreased, whereas after bacterial challenge, TNF- alpha mRNA elevated at 30 h in 7.0-Gy-irradiated mice; at 4, and 8 h in 1.0-Gy-irradiated mice, and at 1 h in sham-irradiated mice (p < 0.05), IL-6 mRNA displayed a biphasic response in 7.0-Gy-irradiated mice, and, after bacterial challenge, in both irradiated mice (1.0- and 7.0-Gy) and sham-irradiated mice. IL-1 beta mRNA remained at or below normal for 8 h and increased at 24 h after bacterial challenge on day 4 in 7.0-Gy-irradiated mice. These results indicate that sublethal gamma radiation alters the patterns of the hematopoietic and proinflammatory cytokine responses to bacterial challenge in vivo. Consequently, treatment protocols may need to take into account changes in cytokine gene responses to resolve infection after irradiation. JF - Journal of Radiation Research AU - Chang, C M AU - Elliott, T B AU - Dobson, ME AU - Jackson, W E AU - Ledney, G D AD - Radiation Medicine Department Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA, Chang@mx.afrri.usuhs.mil Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 259 EP - 277 VL - 41 IS - 3 SN - 0449-3060, 0449-3060 KW - bacteria KW - mice KW - tumor necrosis factor- alpha KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - tumor necrosis factor-a KW - tumor necrosis factor-^a KW - Interleukin 6 KW - ^g Radiation KW - Spleen KW - Inflammation KW - Gene expression KW - Radiation KW - g Radiation KW - Ionizing radiation KW - Hemopoiesis KW - Cytokines KW - Klebsiella pneumoniae KW - J 02855:Human Bacteriology: Others KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17829791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Radiation+Research&rft.atitle=Ionizing+Radiation+and+Bacterial+Challenge+Alter+Splenic+Cytokine+Gene+Expression&rft.au=Chang%2C+C+M%3BElliott%2C+T+B%3BDobson%2C+ME%3BJackson%2C+W+E%3BLedney%2C+G+D&rft.aulast=Chang&rft.aufirst=C&rft.date=2000-09-01&rft.volume=41&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+Radiation+Research&rft.issn=04493060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Klebsiella pneumoniae; Ionizing radiation; Spleen; Cytokines; Gene expression; Radiation; g Radiation; Hemopoiesis; Inflammation; Interleukin 6; ^g Radiation ER - TY - JOUR T1 - Aerobic and anaerobic microbiology in intra-abdominal infections associated with diverticulitis AN - 17618043; 4762621 AB - The aerobic and anaerobic microbiology of intra-abdominal infections associated with diverticulitis was studied in 110 specimens from the peritoneal cavity after intestinal perforation and in 22 specimens from abdominal abscesses. Anaerobic bacteria only were isolated from 17 (15%) of the peritoneal specimens, aerobic bacteria only from 12 (11%) and mixed aerobic and anaerobic flora from 81 (74%). A total of 339 bacterial isolates was detected in peritoneal cultures (3.1 per specimen), comprising 155 aerobes (1.4 per specimen) and 184 anaerobes (1.7 per specimen). Anaerobic bacteria only were isolated in 4 (18%) abscesses, aerobes alone in one (5%) and mixed aerobic and anaerobic flora in 17 (77%). A total of 72 bacterial isolates (3.3 per specimen) was detected in abdominal abscesses - 35 aerobes (1.6 per specimen) and 37 aerobes (1.7 per specimen). The predominant aerobic and facultative bacteria in abdominal infections were Escherichia coli and Streptococcus spp. The most frequently isolated anaerobes were Bacteroides spp. (B. fragilis group), Peptostreptococcus, Clostridium and Fusobacterium spp. JF - Journal of Medical Microbiology AU - Brook, I AU - Frazier, E H AD - Department of Infectious Diseases, Naval Hospital, Bethesda, MD, USA, Brook@mx.afrri.usuhs.mil Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 827 EP - 830 VL - 49 IS - 9 SN - 0022-2615, 0022-2615 KW - man KW - streptococci KW - diverticulitis KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Bacteria KW - Clostridium KW - Abdomen KW - Peptostreptococcus KW - Bacteroides KW - Fusobacterium KW - Escherichia coli KW - Gastrointestinal tract KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17618043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Microbiology&rft.atitle=Aerobic+and+anaerobic+microbiology+in+intra-abdominal+infections+associated+with+diverticulitis&rft.au=Brook%2C+I%3BFrazier%2C+E+H&rft.aulast=Brook&rft.aufirst=I&rft.date=2000-09-01&rft.volume=49&rft.issue=9&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Microbiology&rft.issn=00222615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Streptococcus; Bacteroides; Peptostreptococcus; Clostridium; Fusobacterium; Gastrointestinal tract; Abdomen; Bacteria ER - TY - JOUR T1 - Substitutions in a homologous region of extracellular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry. AN - 71243524; 10827088 AB - CXCR4 and CCR5 are the principal coreceptors for human immunodeficiency virus type-1 (HIV-1) infection. Previously, mutagenesis of CXCR4 identified single amino acid changes that either impaired CXCR4's coreceptor activity for CXCR4-dependent (X4) isolate envelope glycoproteins (Env) or expanded its activity, allowing it to serve as a functional coreceptor for CCR5-dependent (R5) isolates. The most potent of these point mutations was an alanine substitution for the aspartic acid residue at position 187 in extracellular loop 2 (ecl-2), and here we show that this mutation also permits a variety of primary R5 isolate Envs, including those of other subtypes (clades), to employ it as a coreceptor. We also examined the corresponding region of CCR5 and demonstrate that the substitution of the serine residue in the homologous ecl-2 position with aspartic acid impairs CCR5 coreceptor activity for isolates across several clades. These results highlight a homologous and critical element in ecl-2, of both the CXCR4 and CCR5 molecules, for their respective coreceptor activities. Charge elimination expands CXCR4 coreceptor activity, while a similar charge introduction can destroy the coreceptor function of CCR5. These findings provide further evidence that there are conserved elements in both CXCR4 and CCR5 involved in coreceptor function. JF - The Journal of biological chemistry AU - Chabot, D J AU - Broder, C C AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 2000/08/04/ PY - 2000 DA - 2000 Aug 04 SP - 23774 EP - 23782 VL - 275 IS - 31 SN - 0021-9258, 0021-9258 KW - Gene Products, env KW - 0 KW - Receptors, CCR5 KW - Receptors, CXCR4 KW - Viral Fusion Proteins KW - Index Medicus KW - AIDS/HIV KW - Membrane Fusion KW - Cell Fusion KW - Point Mutation KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Gene Products, env -- metabolism KW - HIV-1 -- metabolism KW - Viral Fusion Proteins -- metabolism KW - Receptors, CCR5 -- genetics KW - Receptors, CXCR4 -- metabolism KW - Receptors, CXCR4 -- genetics KW - Receptors, CCR5 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71243524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Substitutions+in+a+homologous+region+of+extracellular+loop+2+of+CXCR4+and+CCR5+alter+coreceptor+activities+for+HIV-1+membrane+fusion+and+virus+entry.&rft.au=Chabot%2C+D+J%3BBroder%2C+C+C&rft.aulast=Chabot&rft.aufirst=D&rft.date=2000-08-04&rft.volume=275&rft.issue=31&rft.spage=23774&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-07 N1 - Date created - 2000-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of antihypertensive effect of dietary potassium in experimental volume expanded hypertension in rats. AN - 72229295; 10972161 AB - Dietary potassium supplementation lowers blood pressure (BP) and attenuates complications in hypertensive subjects, particularly those with the low renin volume expanded (LRVE) variety. We and others have shown that the plasma level of a digitalis like substance (DLS) is elevated in this type of hypertension. We therefore, examined the effect of increases in dietary potassium on the plasma level of endogenous DLS, myocardial and renal Na+, K+-ATPase (NKA) activities, BP, and renal excretory function in reduced renal mass (RRM)-salt hypertension in the rat, a classical model of LRVE hypertension. 70% RRM rats were divided in 4 groups, namely those consuming: 1) a sodium free and normal potassium (1.3% as KCl) diet (RRM-0 Na), 2) a normal sodium and normal potassium diet (RRM-NaK), 3) a normal sodium and high potassium (2 X normal) diet (RRM-Na2K), and 4) a normal sodium and 4 times normal potassium diet (RRM-Na4K). At the end of 4 weeks of dietary treatment, direct BP was recorded, plasma level of DLS determined by bioassay and with a radioimmunoassay for digoxin (DIF) and myocardial and renal NKA activities were measured. As expected, compared to RRM-0Na rats, RRM-NaK rats developed hypertension. BP increased significantly less in RRM-Na2K, whereas BP did not increase in RRM-Na4K rats. Hypertension in RRM-NaK rats was associated with an increase in plasma DLS and DIF and decrease in renal and myocardial NKA activities. DLS was increased (DIF was not changed) and myocardial NKA also decreased in rats consuming double potassium. However, quadrupling potassium in the diet (RRM-Na4K) normalized DLS and DIF and increased myocardial and renal NKA activities, compared to RRM-0Na rats. Also compared to RRM-0Na, water consumption, urinary volume excretion, sodium, and potassium increased in the other 3 groups, more so in RRM-Na4K rats. These data show that quadrupling the potassium in the diet prevents the BP increase in RRM rats and this is associated with diuresis/natriuresis and normalization of DLS, perhaps because the diuresis/natriuresis normalizes blood volume. JF - Clinical and experimental hypertension (New York, N.Y. : 1993) AU - Pamnani, M B AU - Chen, X AU - Haddy, F J AU - Schooley, J F AU - Mo, Z AD - Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 555 EP - 569 VL - 22 IS - 6 SN - 1064-1963, 1064-1963 KW - Potassium, Dietary KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Digoxin KW - 73K4184T59 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Index Medicus KW - Animals KW - Blood Pressure KW - Dose-Response Relationship, Drug KW - Myocardium -- enzymology KW - Nephrectomy -- methods KW - Kidney -- enzymology KW - Digoxin -- blood KW - Rats KW - Sodium-Potassium-Exchanging ATPase -- metabolism KW - Rats, Wistar KW - Diuresis KW - Male KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Potassium, Dietary -- administration & dosage KW - Hypertension -- etiology KW - Potassium, Dietary -- therapeutic use KW - Hypertension -- diet therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72229295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+experimental+hypertension+%28New+York%2C+N.Y.+%3A+1993%29&rft.atitle=Mechanism+of+antihypertensive+effect+of+dietary+potassium+in+experimental+volume+expanded+hypertension+in+rats.&rft.au=Pamnani%2C+M+B%3BChen%2C+X%3BHaddy%2C+F+J%3BSchooley%2C+J+F%3BMo%2C+Z&rft.aulast=Pamnani&rft.aufirst=M&rft.date=2000-08-01&rft.volume=22&rft.issue=6&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Clinical+and+experimental+hypertension+%28New+York%2C+N.Y.+%3A+1993%29&rft.issn=10641963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-28 N1 - Date created - 2000-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Propagation of swell across a wide continental shelf AN - 50158346; 2002-015639 AB - The transformation of ocean swell across a wide, shallow (nominal depths 25-50 m) continental shelf is examined with data from a 100 km long transect of bottom pressure recorders extending from the shelf break to the beach at Duck, North Carolina. The analysis is restricted to periods with light winds when surface boundary layer processes (e.g., wave generation by wind and wave breaking in the form of whitecaps) are expected to be relatively unimportant. The majority of the observations with low-energy incident swell conditions (significant wave heights <1 m) shows weak variations in swell energy across the shelf, in qualitative agreement with predictions of a spectral refraction model. Although the predicted ray trajectories of waves propagating over the irregular shelf bathymetry are quite sensitive to the deep water incident wave directions, the predicted spatial energy variations for broadbanded wave fields are small and relatively insensitive to incident wave conditions, consistent with the observations. Whereas swell dissipation on the shelf appears to be insignificant in low-energy conditions, strong attenuation of swell energy levels (a factor 4 between the shelf break and nearshore sites) was observed in high-energy conditions (significant wave height 2.5 m). This decay, not predicted by the energy-conserving refraction model, indicates that dissipative bottom boundary layer processes can play an important role in the transformation of swell across wide continental shelves. Copyright 2000 by the American Geophysical Union. JF - Journal of Geophysical Research AU - Herbers, T H C AU - Hendrickson, E J AU - O'Reilly, W C Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 19 EP - 19,738 PB - American Geophysical Union, Washington, DC VL - 105 IS - C8 SN - 0148-0227, 0148-0227 KW - United States KW - surface boundary layer KW - orientation KW - Northwest Atlantic KW - elevation KW - Duck North Carolina KW - Dare County North Carolina KW - environmental analysis KW - shallow depth KW - ocean waves KW - North Carolina KW - coastal environment KW - propagation KW - continental shelf KW - bathymetry KW - North Atlantic KW - energy KW - Atlantic Ocean KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50158346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Propagation+of+swell+across+a+wide+continental+shelf&rft.au=Herbers%2C+T+H+C%3BHendrickson%2C+E+J%3BO%27Reilly%2C+W+C&rft.aulast=Herbers&rft.aufirst=T+H&rft.date=2000-08-01&rft.volume=105&rft.issue=C8&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2000JC900085 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 30 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 plate N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; bathymetry; coastal environment; continental shelf; Dare County North Carolina; Duck North Carolina; elevation; energy; environmental analysis; North Atlantic; North Carolina; Northwest Atlantic; ocean waves; orientation; propagation; shallow depth; surface boundary layer; United States DO - http://dx.doi.org/10.1029/2000JC900085 ER - TY - JOUR T1 - DDT house spraying and re-emerging malaria. AN - 72404314; 11071203 JF - Lancet (London, England) AU - Roberts, D R AU - Manguin, S AU - Mouchet, J AD - Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. droberts@usuhs.mil Y1 - 2000/07/22/ PY - 2000 DA - 2000 Jul 22 SP - 330 EP - 332 VL - 356 IS - 9226 SN - 0140-6736, 0140-6736 KW - Insecticides KW - 0 KW - DDT KW - CIW5S16655 KW - Abridged Index Medicus KW - Index Medicus KW - Population KW - Programs KW - Organization And Administration KW - Health KW - Parasite Control KW - Malaria--prevention and control KW - Ingredients And Chemicals KW - Public Health KW - Pesticides KW - Critique KW - Parasitic Diseases KW - World KW - Diseases KW - Animals KW - World Health Organization KW - Insecticide Resistance KW - Housing KW - Humans KW - Anopheles KW - Mosquito Control -- methods KW - Insecticides -- toxicity KW - Malaria -- prevention & control KW - Malaria -- epidemiology KW - DDT -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72404314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=DDT+house+spraying+and+re-emerging+malaria.&rft.au=Roberts%2C+D+R%3BManguin%2C+S%3BMouchet%2C+J&rft.aulast=Roberts&rft.aufirst=D&rft.date=2000-07-22&rft.volume=356&rft.issue=9226&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=01406736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-28 N1 - Date created - 2000-11-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Lancet. 2000 Sep 30;356(9236):1189-90 [11030317] Lancet. 2000 Jul 22;356(9226):265 [11071175] Lancet. 2000 Jul 22;356(9226):267-8 [11071177] Lancet. 2000 Sep 30;356(9236):1189 [11030314] Lancet. 2000 Sep 30;356(9236):1189 [11030315] Lancet. 2000 Sep 30;356(9236):1191 [11030319] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of growth and regulation of IGFs and VEGF in human prostate cancer cell lines by shikonin analogue 93/637 (SA). AN - 72198555; 10953325 AB - Insulin-like growth factors (IGFs) are important mitogens and are involved in normal and malignant cellular proliferation. IGFs and IGF binding proteins (IGFBPs) regulate the prostatic cell growth and reduction/blocking of IGFs has been suggested to be of therapeutic value in prostate cancer. beta,beta-dimethyl acryl shikonin, an extract from the roots of plant Arnebia nobilis has been shown to have anticancer properties but was found to be toxic. Subsequently, several analogoues of beta,beta-dimethyl acryloyl shikonin were synthesized and one of them shikonin analogue 93/637 (SA) was significantly less toxic compared to beta,beta-dimethyl acryloyl shikonin. We have investigated the effect of SA on prostate cancer cell (DU 145, LNCaP and PC-3) growth and expression of IGFs (IGF-I, IGF-II and IGF-I receptor (IGF-IR)), IGFBP-3 and vascular endothelial growth factor (VEGF). SA had growth inhibitory effect on PC-3 cells in a dose dependent manner. It also showed slight inhibitory effect on the growth of DU 145 and LNCaP cells at low doses ranging from 250 nM to 1 microM and has moderate inhibitory effect at concentrations 2.5 microM and above. Lactate dehydrogenase (LDH) activity assays indicated cellular damage, only at higher concentrations of SA that are greater than 1 microM. Gene expression studies by RT-PCR have demonstrated a decrease in mRNAs of IGF-II in DU 145, IGF-I, and IGF-IR in LNCaP, and IGF-II and VEGF in PC-3 cells and an increase in IGFBP-3 in both DU 145 and PC-3 cells by treatment with SA. The results demonstrate the inhibitory effect of SA on cellular growth and IGFs specifically in PC-3 cells and suggest a potential therapeutic use in treatment of prostate cancer. JF - Anticancer research AU - Gaddipati, J P AU - Mani, H AU - Shefali AU - Raj, K AU - Mathad, V T AU - Bhaduri, A P AU - Maheshwari, R K AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. PY - 2000 SP - 2547 EP - 2552 VL - 20 IS - 4 SN - 0250-7005, 0250-7005 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Endothelial Growth Factors KW - Insulin-Like Growth Factor Binding Protein 3 KW - Lymphokines KW - Naphthoquinones KW - RNA, Messenger KW - Receptors, Somatomedin KW - Somatomedins KW - Vascular Endothelial Growth Factor A KW - Vascular Endothelial Growth Factors KW - shikonin KW - 3IK6592UBW KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Tumor Cells, Cultured KW - Cell Survival -- drug effects KW - Humans KW - RNA, Messenger -- analysis KW - Male KW - L-Lactate Dehydrogenase -- metabolism KW - Prostatic Neoplasms -- metabolism KW - Insulin-Like Growth Factor Binding Protein 3 -- genetics KW - Prostatic Neoplasms -- pathology KW - Receptors, Somatomedin -- genetics KW - Naphthoquinones -- pharmacology KW - Lymphokines -- genetics KW - Endothelial Growth Factors -- genetics KW - Antineoplastic Agents, Phytogenic -- pharmacology KW - Prostatic Neoplasms -- drug therapy KW - Somatomedins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72198555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+research&rft.atitle=Inhibition+of+growth+and+regulation+of+IGFs+and+VEGF+in+human+prostate+cancer+cell+lines+by+shikonin+analogue+93%2F637+%28SA%29.&rft.au=Gaddipati%2C+J+P%3BMani%2C+H%3BShefali%3BRaj%2C+K%3BMathad%2C+V+T%3BBhaduri%2C+A+P%3BMaheshwari%2C+R+K&rft.aulast=Gaddipati&rft.aufirst=J&rft.date=2000-07-01&rft.volume=20&rft.issue=4&rft.spage=2547&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-31 N1 - Date created - 2000-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a screen for predicting clinical outcomes in patients with work-related upper extremity disorders. AN - 71258695; 10914343 AB - This study prospectively examined the extent to which a set of medical, physical, ergonomic, occupational psychosocial, and individual psychosocial variables would predict clinical outcome associated with a diverse set of work-related upper extremity disorders in recently diagnosed individuals. This investigation was designed to develop a tool for use in a clinical setting to assist in identifying patients at risk for poorer outcome. Outcome was measured at 1, 3, and 12 months after completing a baseline questionnaire. Outcome status was based on a median split of a standardized composite index (symptoms, function, workdays lost, and mental health). Logistic regression indicated that predictors of poorer outcome at 1 month were: upper extremity comorbidity (risk ratio [RR], 1.58), pain severity (RR, 1.45), ergonomic risk exposure (RR, 1.07), low job support (RR, 1.03), and pain coping style (RR, 1.54). At 3 months, poorer outcome was predicted by: symptom severity (RR, 10.46), job stress (RR, 1.20), and pain coping style (RR, 1.98). The number of prior treatments/providers (RR, 1.77), past recommendation for surgery (RR, 6.43), and pain coping style were found to predict poorer outcome at 12 months. Sensitivity and specificity, respectively, for the models were 77.4% and 71.8% at 1 month, 80.6% and 82.4% at 3 months, and 80.6% and 83.3% at 12 months. The results indicate that baseline measures of ergonomic and psychosocial stress, pain severity, and pain coping style predict clinical outcome at shorter intervals, whereas number of past treatments/providers, recommendation for surgery and pain coping style predict longer-term outcome. The resulting prognostic screen provides a simple tool that assesses the multidimensional nature of work-related upper extremity disorders and predicts clinical outcome. Furthermore, the findings suggest the importance of early intervention that addresses both physical and psychosocial stressors at work. Specific recommendations to reduce the impact of observed risk factors are discussed. JF - Journal of occupational and environmental medicine AU - Feuerstein, M AU - Huang, G D AU - Haufler, A J AU - Miller, J K AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. mfeuerstein@usuhs.mil Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 749 EP - 761 VL - 42 IS - 7 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - District of Columbia KW - Analysis of Variance KW - Prospective Studies KW - Logistic Models KW - Risk Factors KW - Humans KW - Adult KW - Prognosis KW - Middle Aged KW - Male KW - Female KW - Multivariate Analysis KW - Occupational Diseases -- diagnosis KW - Disability Evaluation KW - Arm KW - Musculoskeletal Diseases -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71258695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Development+of+a+screen+for+predicting+clinical+outcomes+in+patients+with+work-related+upper+extremity+disorders.&rft.au=Feuerstein%2C+M%3BHuang%2C+G+D%3BHaufler%2C+A+J%3BMiller%2C+J+K&rft.aulast=Feuerstein&rft.aufirst=M&rft.date=2000-07-01&rft.volume=42&rft.issue=7&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer, thrombosis, and anticoagulants. AN - 71243449; 10912637 AB - Rapid progress has been made recently in our understanding of the pathogenesis of coagulation activation in malignancy and mechanisms by which the coagulation mechanism may control malignant growth. Idiopathic thromboembolic disease may be the sentinel presentation in patients subsequently diagnosed with malignancy. Thrombosis complicating the course of malignancy may be notoriously difficult to treat, but the introduction of the low-molecular-weight heparins has greatly improved management and may obviate the need for invasive approaches, such as the use of inferior vena cava filters, in many cases. Tantalizing clues from clinical trials of anticoagulant therapy in cancer have suggested that components of coagulation pathways may support tumor growth. Many of these can be intercepted using drugs that are well known and non-toxic. The importance of performing high-quality controlled clinical trials that build on past studies and on data from basic research cannot be overemphasized. JF - Current opinion in pulmonary medicine AU - Ornstein, D L AU - Zacharski, L R AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Deborah.Ornstein@59mdw.whmc.af.mil Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 301 EP - 308 VL - 6 IS - 4 SN - 1070-5287, 1070-5287 KW - Anticoagulants KW - 0 KW - Biomarkers KW - Blood Coagulation Factors KW - Index Medicus KW - Thromboembolism -- physiopathology KW - Anticoagulants -- therapeutic use KW - Venous Thrombosis -- physiopathology KW - Venous Thrombosis -- chemically induced KW - Humans KW - Biomarkers -- analysis KW - Vena Cava Filters KW - Blood Coagulation Factors -- analysis KW - Thromboembolism -- chemically induced KW - Blood Coagulation -- physiology KW - Neoplasms -- physiopathology KW - Thrombosis -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71243449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+pulmonary+medicine&rft.atitle=Cancer%2C+thrombosis%2C+and+anticoagulants.&rft.au=Ornstein%2C+D+L%3BZacharski%2C+L+R&rft.aulast=Ornstein&rft.aufirst=D&rft.date=2000-07-01&rft.volume=6&rft.issue=4&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+pulmonary+medicine&rft.issn=10705287&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-21 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Consistent and significant inhibition of human immunodeficiency virus type 1 envelope-mediated membrane fusion by beta-chemokines (RANTES) in primary human macrophages. AN - 71231064; 10882583 AB - Infection and entry of CD4(+) cells by human immunodeficiency virus type 1 (HIV-1) requires a coreceptor molecule, which, in concert with CD4, interacts with the viral envelope glycoprotein (Env), leading to membrane fusion. The principal coreceptors are the CCR5 and CXCR4 chemokine receptors. The suppressive effect of beta-chemokines, principally RANTES, on certain HIV-1 isolates was established before the discovery of the CCR5 receptor, and there have since been multiple reports confirming this initial observation. However, the inhibitory effect of beta-chemokines on HIV-1 infection of macrophages has been controversial. The current study focused on this issue in detail, with a reductionist approach, using assays that measure the effect of beta-chemokines solely on Env-mediated fusion. It is shown that under a variety of culture and differentiation conditions, RANTES maintains a significant and consistent inhibitory effect on CCR5-dependent Env-mediated fusion, and the role of these findings is discussed in relation to the role of beta-chemokines in HIV pathogenesis. JF - The Journal of infectious diseases AU - Stantchev, T S AU - Broder, C C AD - Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. tstanchev@mxb.usuhs.mil Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 68 EP - 78 VL - 182 IS - 1 SN - 0022-1899, 0022-1899 KW - Chemokine CCL5 KW - 0 KW - Chemokines, CC KW - Chemokines, CXC KW - HIV Envelope Protein gp120 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Chemokines, CXC -- pharmacology KW - HIV Envelope Protein gp120 -- physiology KW - Drug Interactions KW - Chemokines, CC -- pharmacology KW - HeLa Cells KW - Humans KW - HIV Envelope Protein gp120 -- drug effects KW - Granulocyte-Macrophage Colony-Stimulating Factor -- pharmacology KW - Chemokine CCL5 -- pharmacology KW - Membrane Fusion -- drug effects KW - Macrophages -- virology KW - Macrophages -- physiology KW - HIV-1 -- physiology KW - Macrophages -- drug effects KW - HIV-1 -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71231064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Consistent+and+significant+inhibition+of+human+immunodeficiency+virus+type+1+envelope-mediated+membrane+fusion+by+beta-chemokines+%28RANTES%29+in+primary+human+macrophages.&rft.au=Stantchev%2C+T+S%3BBroder%2C+C+C&rft.aulast=Stantchev&rft.aufirst=T&rft.date=2000-07-01&rft.volume=182&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-28 N1 - Date created - 2000-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - U.S. Arms Sales to Taiwan: Implications for the Future of the Sino-U.S. Relationship AN - 60571493; 200108176 AB - The US remains essentially the only country involved in selling arms to Taiwan. As a result, arms sales have become one of the most evident areas of dispute between the US & the People's Republic of China. US arms sales to Taiwan have been affected by several complicating factors: the ever-expanding role of post-Cold War nationalism in China; altered strategic conditions; the complications that result from differing interpretations of the 1982 US-PRC Joint Communique & the 1979 US Taiwan Relations Act; the modernization of China's military; Taiwan's self-determination goals; & a decline in US military spending. These factors have forced the US into a position of power within the political, cultural, & military web of issues dominating the PRC-Taiwan relationship. If China's goals for reunification are ever to be achieved, the power that the US currently wields must be neutralized. K. A. Larsen JF - Asian Survey AU - McClaran, John P AD - Center Civil Military Relations, Naval Postgraduate School, Monterey, CA Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 622 EP - 640 VL - 40 IS - 4 SN - 0004-4687, 0004-4687 KW - Peoples Republic of China KW - Taiwan KW - Geopolitics KW - Armaments KW - United States of America KW - International Relations KW - National Security KW - article KW - 9063: international relations; international relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60571493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Survey&rft.atitle=U.S.+Arms+Sales+to+Taiwan%3A+Implications+for+the+Future+of+the+Sino-U.S.+Relationship&rft.au=McClaran%2C+John+P&rft.aulast=McClaran&rft.aufirst=John&rft.date=2000-07-01&rft.volume=40&rft.issue=4&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Asian+Survey&rft.issn=00044687&rft_id=info:doi/ LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Taiwan; United States of America; Peoples Republic of China; Armaments; International Relations; National Security; Geopolitics ER - TY - JOUR T1 - Undertow over a barred beach AN - 52204841; 2001-057685 JF - Journal of Geophysical Research AU - Garcez Faria, A F AU - Thornton, E B AU - Lippmann, T C AU - Stanton, T P Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 10 EP - 17,010 PB - American Geophysical Union, Washington, DC VL - 105 IS - C7 SN - 0148-0227, 0148-0227 KW - undertow KW - currents KW - wave height transformation KW - shore features KW - breaking waves KW - barrier beaches KW - bars KW - turbulence KW - ocean currents KW - boundary conditions KW - eddies KW - ocean waves KW - coastal environment KW - laser Doppler velocimetry KW - field studies KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52204841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Undertow+over+a+barred+beach&rft.au=Garcez+Faria%2C+A+F%3BThornton%2C+E+B%3BLippmann%2C+T+C%3BStanton%2C+T+P&rft.aulast=Garcez+Faria&rft.aufirst=A&rft.date=2000-07-01&rft.volume=105&rft.issue=C7&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/ L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 34 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - barrier beaches; bars; boundary conditions; breaking waves; coastal environment; currents; eddies; field studies; laser Doppler velocimetry; ocean currents; ocean waves; shore features; turbulence; undertow; wave height transformation ER - TY - JOUR T1 - Interferon regulatory factor (IRF)-1 and IRF-2 regulate interferon gamma-dependent cyclooxygenase 2 expression. AN - 71196452; 10859338 AB - Cyclooxygenases (Cox) are rate-limiting enzymes that initiate the conversion of arachidonic acid to prostanoids. Cox-2 is the inducible isoform that is upregulated by proinflammatory agents, initiating many prostanoid-mediated pathological aspects of inflammation. In this study, we demonstrate that interferon (IFN)-gamma alone or in synergy with lipopolysaccharide (LPS) or interleukin 1alpha induces Cox-2 expression in mouse peritoneal macrophages, which is paralleled by changes in Cox-2 protein levels and prostaglandin E(2) (PGE(2)) release. Induction of Cox-2 was abrogated in macrophages that lack IFN regulatory factor (IRF)-1, consistent with an attenuated hepatic mRNA response in IRF-1(-/-) mice injected with LPS. Conversely, the absence of IRF-2 in macrophages resulted in a significant increase in both basal and inducible Cox-2 gene and protein expression as well as IFN-gamma-stimulated PGE(2) release, identifying IRF-2 as negative regulator of this promoter. Two IFN stimulation response elements were identified in the mouse Cox-2 promoter that were highly conserved in the human Cox-2 gene. Both bind endogenous IRF-1 and IRF-2 and regulate transcription in an IRF-1/2-dependent manner. Our data demonstrate conclusively the importance of IFN-gamma as a direct activator and coactivator of the Cox-2 gene, and the central role of IRF-1/2 family members in this process. JF - The Journal of experimental medicine AU - Blanco, J C AU - Contursi, C AU - Salkowski, C A AU - DeWitt, D L AU - Ozato, K AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 2000/06/19/ PY - 2000 DA - 2000 Jun 19 SP - 2131 EP - 2144 VL - 191 IS - 12 SN - 0022-1007, 0022-1007 KW - DNA-Binding Proteins KW - 0 KW - Interferon Regulatory Factor-1 KW - Interferon Regulatory Factor-2 KW - Interleukin-1 KW - Irf1 protein, mouse KW - Irf2 protein, mouse KW - Isoenzymes KW - Lipopolysaccharides KW - Phosphoproteins KW - Repressor Proteins KW - Transcription Factors KW - Interferon-gamma KW - 82115-62-6 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Prostaglandin-Endoperoxide Synthases KW - Index Medicus KW - Animals KW - Interleukin-1 -- pharmacology KW - Liver -- immunology KW - Lipopolysaccharides -- pharmacology KW - Shock, Septic -- etiology KW - Transcription, Genetic KW - Mice KW - Protein Binding KW - Binding Sites KW - Promoter Regions, Genetic KW - Mice, Mutant Strains KW - Gene Expression Regulation, Enzymologic KW - Shock, Septic -- immunology KW - Response Elements KW - Drug Synergism KW - Phosphoproteins -- genetics KW - Isoenzymes -- biosynthesis KW - Interferon-gamma -- metabolism KW - DNA-Binding Proteins -- genetics KW - Prostaglandin-Endoperoxide Synthases -- genetics KW - Isoenzymes -- genetics KW - Prostaglandin-Endoperoxide Synthases -- biosynthesis KW - Phosphoproteins -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71196452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+experimental+medicine&rft.atitle=Interferon+regulatory+factor+%28IRF%29-1+and+IRF-2+regulate+interferon+gamma-dependent+cyclooxygenase+2+expression.&rft.au=Blanco%2C+J+C%3BContursi%2C+C%3BSalkowski%2C+C+A%3BDeWitt%2C+D+L%3BOzato%2C+K%3BVogel%2C+S+N&rft.aulast=Blanco&rft.aufirst=J&rft.date=2000-06-19&rft.volume=191&rft.issue=12&rft.spage=2131&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+experimental+medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-25 N1 - Date created - 2000-07-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Mar 3;275(9):6259-66 [10692422] Biochemistry. 1967 Aug;6(8):2363-72 [4867999] J Biol Chem. 1996 Dec 27;271(52):33157-60 [8969167] J Clin Invest. 1997 Mar 1;99(5):1057-63 [9062364] J Neurosci. 1997 Apr 15;17(8):2746-55 [9092596] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3336-40 [9096394] Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1788-93 [9465095] J Biol Chem. 1998 Mar 13;273(11):6431-8 [9497375] Biochem Biophys Res Commun. 1998 Mar 6;244(1):143-8 [9514889] J Immunol. 1998 Sep 1;161(5):2441-8 [9725242] J Immunol. 1998 Sep 1;161(5):2490-500 [9725248] Methods. 1998 Jul;15(3):167-74 [9735302] J Biol Chem. 1998 Oct 16;273(42):27686-94 [9765305] J Exp Med. 1999 Feb 15;189(4):719-27 [9989987] Mol Cell Biol. 1999 Mar;19(3):1810-20 [10022868] J Biol Chem. 1999 Mar 5;274(10):6698-703 [10037767] J Biol Chem. 1999 Apr 2;274(14):9342-50 [10092612] J Immunol. 1999 Jun 15;162(12):7256-62 [10358173] Nucleic Acids Res. 1982 Nov 11;10(21):6763-75 [6294614] Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 [6828386] J Immunol. 1987 May 1;138(9):2857-63 [3106491] J Immunol. 1988 Oct 1;141(7):2407-12 [3139757] Cell. 1989 Aug 25;58(4):729-39 [2475256] Proc Natl Acad Sci U S A. 1989 Dec;86(24):9936-40 [2557635] Cell. 1990 Oct 19;63(2):303-12 [2208287] Mol Cell Biol. 1991 Jan;11(1):182-91 [1898761] Nucleic Acids Res. 1991 Aug 25;19(16):4421-8 [1886766] Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4888-92 [1594589] Am J Physiol. 1992 Aug;263(2 Pt 2):F181-91 [1324603] Adv Immunol. 1992;52:263-81 [1442307] J Biol Chem. 1992 Dec 25;267(36):25934-8 [1464605] Mol Cell Biol. 1993 Jan;13(1):690-702 [7678055] Science. 1993 Feb 12;259(5097):971-4 [8438157] J Exp Med. 1993 Jun 1;177(6):1779-84 [7684434] Mol Cell Biol. 1993 Aug;13(8):4531-8 [7687740] J Exp Med. 1993 Aug 1;178(2):605-13 [7688028] Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9730-4 [7692452] J Biol Chem. 1994 Feb 18;269(7):4705-8 [7508926] Science. 1994 Mar 18;263(5153):1612-5 [7510419] J Immunol. 1994 Mar 1;152(5):2270-8 [8133040] J Immunol. 1994 Apr 15;152(8):4110-8 [7511667] J Leukoc Biol. 1994 Apr;55(4):476-82 [8145018] Oncogene. 1994 May;9(5):1423-8 [8152803] J Biol Chem. 1994 Apr 22;269(16):11769-75 [8163473] Proc Natl Acad Sci U S A. 1994 May 24;91(11):5046-50 [8197182] Science. 1994 Jun 24;264(5167):1921-4 [8009222] FEBS Lett. 1994 Aug 15;350(1):51-4 [8062923] J Exp Med. 1994 Sep 1;180(3):977-84 [7520478] Gastroenterology. 1994 Oct;107(4):1183-8 [7926468] Mol Cell Biol. 1994 Oct;14(10):6531-9 [7935375] Infect Immun. 1995 Feb;63(2):601-8 [7822029] Cancer Res. 1995 Jun 15;55(12):2556-9 [7780968] Semin Nephrol. 1995 May;15(3):179-94 [7631045] Cancer Res. 1995 Sep 1;55(17):3785-9 [7641194] Virology. 1995 Aug 1;211(1):113-22 [7645205] J Biol Chem. 1995 Nov 17;270(46):27622-8 [7499226] J Biol Chem. 1995 Dec 29;270(52):31315-20 [8537402] Nucleic Acids Res. 1995 Dec 11;23(23):4878-84 [8532532] J Immunol. 1996 May 1;156(9):3107-10 [8617930] J Immunol. 1996 May 15;156(10):3711-20 [8621906] Arch Biochem Biophys. 1996 Jun 15;330(2):319-28 [8660662] Gastroenterology. 1996 Aug;111(2):445-54 [8690211] J Immunol. 1996 Mar 15;156(6):2240-6 [8690914] Mol Cell Biol. 1996 Nov;16(11):6313-24 [8887661] J Immunol. 1999 Jul 15;163(2):963-9 [10395693] Acta Neuropathol. 1999 Jul;98(1):9-14 [10412795] Cell. 1999 Jul 9;98(1):1-4 [10412974] J Immunol. 1999 Aug 1;163(3):1529-36 [10415056] Am J Physiol. 1999 Jul;277(1 Pt 2):F10-6 [10409292] J Biol Chem. 1999 Oct 8;274(41):29138-48 [10506169] Gene. 1999 Sep 3;237(1):1-14 [10524230] Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10966-71 [9724813] Annu Rev Immunol. 1997;15:749-95 [9143706] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6500-5 [9177247] Biochim Biophys Acta. 1997 Aug 8;1333(1):M9-17 [9294015] J Exp Med. 1997 Nov 3;186(9):1523-34 [9348310] J Exp Med. 1997 Nov 3;186(9):1535-46 [9348311] FEBS Lett. 1997 Nov 24;418(1-2):175-8 [9414121] J Immunol. 1999 Dec 15;163(12):6820-6 [10586082] Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):91-6 [10618376] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Resident participation in flexible sigmoidoscopy does not affect patient satisfaction. AN - 85349952; pmid-10894597 AB - OBJECTIVE: We sought to assess the effect of resident involvement in flexible sigmoidoscopy on patient satisfaction and comfort. METHODS: Adults undergoing flexible sigmoidoscopy completed a previsit questionnaire on indication for procedure, GI-related history, and functional status. Immediately after the procedure, satisfaction and procedure comfort were assessed. Additional information collected included procedure duration, depth of sigmoidoscope penetration, and visualization of diverticuli or polyps. RESULTS: Among 408 endoscopies, patient characteristics and procedure indications were similar between sigmoidoscopies done by residents (n = 111) or staff. There were no differences in patient satisfaction, procedure comfort, or willingness to undergo the procedure again in the future. Sigmoidoscopies involving residents averaged 5.6 min longer, even after adjusting for preparation quality, depth of insertion, specific endoscopist, and the presence of polyps or diverticuli. CONCLUSIONS: Patient satisfaction and comfort with flexible sigmoidoscopy was not reduced by resident involvement, though the procedure duration was slightly longer. JF - The American journal of gastroenterology AU - Jackson, J L AU - Osgard, E AU - Fincher, R K AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 1563 EP - 1566 VL - 95 IS - 6 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Pliability KW - Sigmoidoscopes KW - Humans KW - Middle Aged KW - Time Factors KW - Female KW - Male KW - Sigmoidoscopy KW - Patient Satisfaction KW - Internship and Residency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85349952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Resident+participation+in+flexible+sigmoidoscopy+does+not+affect+patient+satisfaction.&rft.au=Jackson%2C+J+L%3BOsgard%2C+E%3BFincher%2C+R+K&rft.aulast=Jackson&rft.aufirst=J&rft.date=2000-06-01&rft.volume=95&rft.issue=6&rft.spage=1563&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Asbestos exposure induces MCP-1 secretion by pleural mesothelial cells. AN - 71270143; 10923243 AB - We showed previously that both crocidolite and chrysotile asbestos inhalation induced a persistent macrophage inflammatory response within the pleural space of the rat. We postulated that the stimulus for pleural macrophage recruitment after asbestos exposure was the induction of monocyte chemoattractant protein-1 (MCP-1) synthesis by pleural mesothelial cells. To test this hypothesis, rat pleural mesothelial cells (RPMC) were cultured with or without chrysotile or crocidolite asbestos fibers (8 micrograms/cm2) in the presence (50 ng/mL) or absence of either tumor necrosis factor-alpha (TNF-alpha) or interleukin-1 beta (IL-1 beta). MCP-1 mRNA expression was assessed by RT-PCR in RPMC cultured for 2 to 24 hours, and MCP-1 protein secretion was measured by ELISA in conditioned medium from 24-hour and 48-hour cultures. Crocidolite and chrysotile fibers induced MCP-1 mRNA expression in RPMC which was maximal after 12 hours in the absence of cytokines, but which peaked after 2 hours when RPMC were challenged with asbestos + TNF-alpha or IL-1 beta. Both types of asbestos also significantly increased MCP-1 protein secretion after 24 and 48 hours (P < .0001), an effect that was potentiated by cytokine stimulation. Rats exposed by inhalation to either chrysotile or crocidolite asbestos fibers also had greater amounts of MCP-1 protein in their pleural lavage fluid than did sham-exposed rats. These findings suggest that MCP-1 secretion by RPMC may have a role in the initiation and/or potentiation of asbestos-induced pleural injury. JF - Experimental lung research AU - Tanaka, S AU - Choe, N AU - Iwagaki, A AU - Hemenway, D R AU - Kagan, E AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 241 EP - 255 VL - 26 IS - 4 SN - 0190-2148, 0190-2148 KW - Asbestos, Serpentine KW - 0 KW - Chemokine CCL2 KW - Cytokines KW - Mineral Fibers KW - RNA, Messenger KW - Asbestos, Crocidolite KW - 12001-28-4 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Cytokines -- pharmacology KW - Humans KW - RNA, Messenger -- drug effects KW - Cell Culture Techniques KW - Rats KW - Asbestos, Crocidolite -- pharmacology KW - Rats, Inbred F344 KW - RNA, Messenger -- metabolism KW - Inhalation Exposure KW - Asbestos, Serpentine -- pharmacology KW - Male KW - Chemokine CCL2 -- genetics KW - Epithelial Cells -- secretion KW - Chemokine CCL2 -- secretion KW - Asbestos -- pharmacology KW - Pleura -- chemistry KW - Pleura -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71270143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Asbestos+exposure+induces+MCP-1+secretion+by+pleural+mesothelial+cells.&rft.au=Tanaka%2C+S%3BChoe%2C+N%3BIwagaki%2C+A%3BHemenway%2C+D+R%3BKagan%2C+E&rft.aulast=Tanaka&rft.aufirst=S&rft.date=2000-06-01&rft.volume=26&rft.issue=4&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-28 N1 - Date created - 2000-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A probability model of vector behavior: effects of DDT repellency, irritancy, and toxicity in malaria control. AN - 71261516; 10925797 AB - A probability model of how DDT residues may function within a malaria control program is described. A step-wise organization of endophagic behaviors culminates in a vector acquiring a human blood meal inside the house. Different vector behaviors are described, epidemiologically defined, temporally sequenced, and quantified with field data. Components of vector behavior and the repellent, irritant, and toxic actions of insecticide residues are then assembled into a probability model. The sequence of host-seeking behaviors is used to partition the total impact of sprayed walls according to the three chemical actions. Quantitatively, the combined effect of repellency and irritancy exert the dominant actions of DDT residues in reducing man-vector contact inside of houses. These relationships are demonstrated with published and unpublished data for two separate populations of Anopheles darlingi, for Anopheles gambiae and Anopheles funestus in Tanzania, and Anopheles punctulatus in New Guinea. JF - Journal of vector ecology : journal of the Society for Vector Ecology AU - Roberts, D R AU - Alecrim, W D AU - Hshieh, P AU - Grieco, J P AU - Bangs, M AU - Andre, R G AU - Chareonviriphap, T AD - Department of Preventive Medicine/Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 48 EP - 61 VL - 25 IS - 1 SN - 1081-1710, 1081-1710 KW - DDT KW - CIW5S16655 KW - Index Medicus KW - Probability KW - Animals KW - Housing KW - Humans KW - Models, Statistical KW - Malaria -- prevention & control KW - Anopheles KW - Insect Vectors KW - Pest Control -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71261516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+vector+ecology+%3A+journal+of+the+Society+for+Vector+Ecology&rft.atitle=A+probability+model+of+vector+behavior%3A+effects+of+DDT+repellency%2C+irritancy%2C+and+toxicity+in+malaria+control.&rft.au=Roberts%2C+D+R%3BAlecrim%2C+W+D%3BHshieh%2C+P%3BGrieco%2C+J+P%3BBangs%2C+M%3BAndre%2C+R+G%3BChareonviriphap%2C+T&rft.aulast=Roberts&rft.aufirst=D&rft.date=2000-06-01&rft.volume=25&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Journal+of+vector+ecology+%3A+journal+of+the+Society+for+Vector+Ecology&rft.issn=10811710&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison study of house entering and exiting behavior of Anopheles vestitipennis (Diptera: Culicidae) using experimental huts sprayed with DDT or deltamethrin in the southern district of Toledo, Belize, C.A. AN - 71256041; 10925798 AB - An investigation of the house entering and exiting behavior of Anopheles vestitipennis Dyar and Knab was undertaken in the Toledo District of Belize, Central America, between March and December of 1998. Three untreated experimental huts were either fitted with exit or entrance interception traps or used as a control for human landing collections. Human landing collections showed that An. vestitipennis exhibited a high level of biting activity shortly after sunset and continued biting at high levels throughout the night. Under unsprayed conditions, the use of exit and entrance interception traps demonstrated that doors, windows, and eaves were the primary mode of entry; whereas, cracks in the walls served a secondary role. The peak entrance time for An. vestitipennis occurred between 6:45 P.M. and 9:45 P.M. and a peak exit time occurred between 11:45 P.M. and 4:45 A.M. Additional trials were conducted after spraying one of the huts with DDT and another with deltamethrin. The excito-repellent properties of deltamethrin did not affect entrance times but did result in a peak exiting behavior that was five hours earlier than under pre-spray conditions. Deltamethrin also exhibited a repellency effect, showing 66% fewer An. vestitipennis entering the hut two weeks post-spray. DDT had an even more powerful repellency effect resulting in a 97% post-spray reduction of An. vestitipennis females entering the hut up to two weeks post-spray. The control hut showed only a 37% reduction in An. vestitipennis as compared to pre-spray conditions. JF - Journal of vector ecology : journal of the Society for Vector Ecology AU - Grieco, J P AU - Achee, N L AU - Andre, R G AU - Roberts, D R AD - Department of Preventive Medicine/Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 62 EP - 73 VL - 25 IS - 1 SN - 1081-1710, 1081-1710 KW - Insecticides KW - 0 KW - Nitriles KW - Pyrethrins KW - decamethrin KW - 2JTS8R821G KW - DDT KW - CIW5S16655 KW - Index Medicus KW - Belize KW - Animals KW - Humans KW - Seasons KW - Geography KW - Time Factors KW - Insect Bites and Stings -- epidemiology KW - Housing KW - Pest Control -- methods KW - Anopheles -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71256041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+vector+ecology+%3A+journal+of+the+Society+for+Vector+Ecology&rft.atitle=A+comparison+study+of+house+entering+and+exiting+behavior+of+Anopheles+vestitipennis+%28Diptera%3A+Culicidae%29+using+experimental+huts+sprayed+with+DDT+or+deltamethrin+in+the+southern+district+of+Toledo%2C+Belize%2C+C.A.&rft.au=Grieco%2C+J+P%3BAchee%2C+N+L%3BAndre%2C+R+G%3BRoberts%2C+D+R&rft.aulast=Grieco&rft.aufirst=J&rft.date=2000-06-01&rft.volume=25&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Journal+of+vector+ecology+%3A+journal+of+the+Society+for+Vector+Ecology&rft.issn=10811710&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Spouse abuse recidivism in the U.S. Army by gender and military status. AN - 71232713; 10883570 AB - Recidivism by spouse abusers was investigated using records of offenders in the U.S. Army Central Registry. Recidivism by gender and military status (active-duty or civilian spouse) was compared over a 70-month period. Between fiscal years 1989-1997, 48,330 offenders were identified in initial and recidivist incidents. Recidivism was analyzed by means of a Cox proportional hazard rate model, controlling for age, race, number of dependents, education, and substance abuse. Two different sets of survival curves were obtained: (a) Men were much more likely than women to have a recurrence and (b) within gender, civilians were more likely to have a recurrence than were active-duty military personnel. At 70 months, 30% of the male civilian offenders and 27% of the male active-duty offenders had committed a subsequent spouse abuse incident compared with 20% of the female civilian offenders and 18% of the female active-duty offenders, controlling for other variables. JF - Journal of consulting and clinical psychology AU - McCarroll, J E AU - Thayer, L E AU - Liu, X AU - Newby, J H AU - Norwood, A E AU - Fullerton, C S AU - Ursano, R J AD - Department of Psychiatry, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland 20814-4799, USA. jmccarroll@usuhs.mil Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 521 EP - 525 VL - 68 IS - 3 SN - 0022-006X, 0022-006X KW - Index Medicus KW - ROC Curve KW - Humans KW - Employment KW - Registries KW - Adult KW - Confounding Factors (Epidemiology) KW - Substance-Related Disorders KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Male KW - Secondary Prevention KW - Proportional Hazards Models KW - Military Personnel -- statistics & numerical data KW - Spouse Abuse -- statistics & numerical data KW - Spouse Abuse -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71232713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=Spouse+abuse+recidivism+in+the+U.S.+Army+by+gender+and+military+status.&rft.au=McCarroll%2C+J+E%3BThayer%2C+L+E%3BLiu%2C+X%3BNewby%2C+J+H%3BNorwood%2C+A+E%3BFullerton%2C+C+S%3BUrsano%2C+R+J&rft.aulast=McCarroll&rft.aufirst=J&rft.date=2000-06-01&rft.volume=68&rft.issue=3&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-01 N1 - Date created - 2000-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rethinking Public Administration's Roots in Pragmatism: The Case of Charles A. Beard AN - 60564027; 200101255 AB - This article portrays the pragmatism of Charles S. Peirce, William James, & John Dewey as an insignificant influence during the early years of American public administration. The mainstream thinking during that time was exemplified by the ideas of Charles A. Beard, an influential figure in the early era of the field. Beard's writings illustrate the way public administration ignored important aspects of pragmatism in favor of practical attitudes & focus on apolitical efficiency. As a result, administrative orthodoxy developed in opposition to pragmatism, which explains the abandonment & misinterpretation of Mary Parker Follett's ideas. Equipped with the recognition that public administration has never really given pragmatism a chance, scholars & practitioners may be led to consider its possibilities in a contemporary administrative context. 79 References. Adapted from the source document. JF - American Review of Public Administration AU - Snider, Keith F AD - Dept Systems Management, Naval Postgraduate School, Monterey, CA Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 123 EP - 145 VL - 30 IS - 2 SN - 0275-0740, 0275-0740 KW - Beard, Charles A. KW - United States of America KW - Pragmatism KW - Public Administration KW - article KW - 9263: public policy/administration; public administration/bureaucracy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60564027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Review+of+Public+Administration&rft.atitle=Rethinking+Public+Administration%27s+Roots+in+Pragmatism%3A+The+Case+of+Charles+A.+Beard&rft.au=Snider%2C+Keith+F&rft.aulast=Snider&rft.aufirst=Keith&rft.date=2000-06-01&rft.volume=30&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=American+Review+of+Public+Administration&rft.issn=02750740&rft_id=info:doi/ LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Public Administration; Pragmatism; United States of America ER - TY - JOUR T1 - A modeling study of the coastal eastern boundary current system off Iberia and Morocco AN - 50157081; 2001-011224 AB - To investigate the northern Canary Current system (NCCS), results from four numerical experiments of increasing complexity are examined. Experiment 1, which uses seasonal wind forcing only, shows that as expected, wind forcing is the key generative mechanism for the current, upwelling, meander, eddy, and filament structures. Experiments 2 and 3, which have the additional effects of irregular coastline geometry, show the following: capes are areas for enhanced upwelling, extensive filaments, maximum current velocities, and enhanced growth of cyclonic meanders and eddies; an embayment like the Gulf of Cadiz is a primary region for anticyclonic meander and eddy development. The results from the complex flow regime of Experiment 4, which has the additional effects of thermohaline gradients and Mediterranean Outflow, highlights the major characteristics and unique features (such as the generation of Meddies) of the NCCS with relatively close similarities to field observations. Copyright 2000 by the American Geophysical Union. JF - Journal of Geophysical Research AU - Bateen, Mary L AU - Martinez, Johnny R AU - Bryan, Daniel W AU - Buch, Eric J Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 14 EP - 14,195 PB - American Geophysical Union, Washington, DC VL - 105 IS - C6 SN - 0148-0227, 0148-0227 KW - currents KW - ocean circulation KW - Morocco KW - North Africa KW - Europe KW - Iberian Peninsula KW - ocean currents KW - Southern Europe KW - models KW - northern Canary current system KW - Africa KW - East Atlantic KW - Gulf of Cadiz KW - North Atlantic KW - eastern boundary current KW - Atlantic Ocean KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50157081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=A+modeling+study+of+the+coastal+eastern+boundary+current+system+off+Iberia+and+Morocco&rft.au=Bateen%2C+Mary+L%3BMartinez%2C+Johnny+R%3BBryan%2C+Daniel+W%3BBuch%2C+Eric+J&rft.aulast=Bateen&rft.aufirst=Mary&rft.date=2000-06-01&rft.volume=105&rft.issue=C6&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2000JC900026 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 58 N1 - PubXState - DC N1 - Document feature - illus. incl. geol. sketch map, 2 tables, sect. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Africa; Atlantic Ocean; currents; East Atlantic; eastern boundary current; Europe; Gulf of Cadiz; Iberian Peninsula; models; Morocco; North Africa; North Atlantic; northern Canary current system; ocean circulation; ocean currents; Southern Europe DO - http://dx.doi.org/10.1029/2000JC900026 ER - TY - JOUR T1 - Response of the South China Sea to tropical cyclone Ernie 1996 AN - 50154315; 2001-011213 AB - A moving tropical cyclone is an intense localized source of surface wind stress and wind stress curl that produces a significant response in the ocean environment, especially in the ocean thermal structure, the upper ocean currents, and the sea surface elevation. Such a response has been well identified in the open-ocean region, but not in the coastal ocean region. In this study we use the Princeton Ocean Model with 20 km horizontal resolution and 23 sigma levels conforming to a realistic bottom topography to identify the response of the South China Sea to Tropical Cyclone Ernie 1996. Results show strong similarities in the responses between open ocean and coastal regions, including near-surface strong asymmetric response such as divergent currents with near-inertial oscillations, significant sea surface temperature cooling, biase to the right of the storm track, sea surface depressions in the wake of the storm, and subsurface intense upwelling and cooling at the base of the mixed layer to the right of the storm track. The unique features of the SCS response to Ernie are also discussed. Copyright 2000 by the American Geophysical Union. JF - Journal of Geophysical Research AU - Chu, Peter C AU - Veneziano, Joseph M AU - Fan, Chenwu AU - Carron, Michael J AU - Liu, W Timothy Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 9 EP - 14,009 PB - American Geophysical Union, Washington, DC VL - 105 IS - C6 SN - 0148-0227, 0148-0227 KW - tropical environment KW - currents KW - sea surface height KW - stress KW - environmental analysis KW - Tropical Cyclone Ernie 1996 KW - ocean currents KW - West Pacific KW - North Pacific KW - Pacific Ocean KW - Northwest Pacific KW - winds KW - South China Sea KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50154315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Response+of+the+South+China+Sea+to+tropical+cyclone+Ernie+1996&rft.au=Chu%2C+Peter+C%3BVeneziano%2C+Joseph+M%3BFan%2C+Chenwu%3BCarron%2C+Michael+J%3BLiu%2C+W+Timothy&rft.aulast=Chu&rft.aufirst=Peter&rft.date=2000-06-01&rft.volume=105&rft.issue=C6&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2000JC900035 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 39 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table, geol. sketch maps N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - currents; environmental analysis; North Pacific; Northwest Pacific; ocean currents; Pacific Ocean; sea surface height; South China Sea; stress; Tropical Cyclone Ernie 1996; tropical environment; West Pacific; winds DO - http://dx.doi.org/10.1029/2000JC900035 ER - TY - JOUR T1 - Engineering radiation-resistant bacteria for environmental biotechnology AN - 17652551; 4732191 AB - Seventy million cubic meters of ground and three trillion liters of groundwater have been contaminated by leaking radioactive waste generated in the United States during the Cold War. A cleanup technology is being developed based on the radiation-resistant bacterium Deinococcus radiodurans, which is being engineered to express bioremediating functions. JF - Current Opinion in Biotechnology AU - Daly, MJ AD - Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA, mdaly@usuhs.mil Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 280 EP - 285 VL - 11 IS - 3 SN - 0958-1669, 0958-1669 KW - bacteria KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Bioremediation KW - Radiation KW - Reviews KW - Radioresistance KW - Deinococcus radiodurans KW - Environmental factors KW - Biotechnology KW - W2 32000:General topics and reviews KW - W2 32510:Waste treatment, environment, pollution KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17652551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Engineering+radiation-resistant+bacteria+for+environmental+biotechnology&rft.au=Daly%2C+MJ&rft.aulast=Daly&rft.aufirst=MJ&rft.date=2000-06-01&rft.volume=11&rft.issue=3&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2FS0958-1669%2800%2900096-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Deinococcus radiodurans; Reviews; Environmental factors; Biotechnology; Radiation; Radioresistance; Bioremediation DO - http://dx.doi.org/10.1016/S0958-1669(00)00096-3 ER - TY - JOUR T1 - The Effect of Vehicle Traffic on Wildlife in Denali National Park AN - 17552371; 4737191 AB - We recorded observations of caribou (Rangifer tarandus), grizzly bear (Ursus arctos), Dall sheep (Ovis dalli) and moose (Alces alces) along the Denali National Park and Preserve road corridor during 1995-97. We compared these observations to similar data from previous studies to evaluate the effect of an increase in traffic on the number of animals sighted and their behavior. Between 1972 and 1997, annual visitation to Denali National Park increased from about 45 000 to 350 000, with attendant increases in traffic on the park road. The mean number of caribou, grizzly bear, and Dall sheep observed did not decline (p > 0.301) from 1973 to 1997. The number of moose observed declined by more than 50% (R super(2) = 0.529, p 0.787), but fewer moose (p < 0.031) were observed within 100 m of the road and fewer sheep (p < 0.011) were observed between 400 and 500 m from the road. Adverse behavioral responses to traffic (e.g., running from vehicles) occurred in less than 1.3% of observations for each species. Increased traffic on the park road apparently has not caused significant changes in abundance, distribution, or behavior of caribou, grizzly bear, Dall sheep, and moose in the park road corridor. JF - Arctic AU - Burson, SL III AU - Belant, J L AU - Fortier, KA AU - Tomkiewicz, WC III AD - Denali National Park and Preserve, Division of Research and Resource Preservation, P.O. Box 9, Denali Park, AK 99755, USA, Jerry_Belant@nps.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 146 EP - 151 VL - 53 IS - 2 SN - 0004-0843, 0004-0843 KW - Caribou KW - Brown bear KW - Dall sheep KW - Moose KW - USA, Alaska KW - Ecology Abstracts KW - Alces alces KW - Motor vehicles KW - Wildlife KW - Rangifer tarandus KW - Population levels KW - Ursus arctos KW - Ovis dalli KW - Human impact KW - D 04712:Environmental degradation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17552371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arctic&rft.atitle=The+Effect+of+Vehicle+Traffic+on+Wildlife+in+Denali+National+Park&rft.au=Burson%2C+SL+III%3BBelant%2C+J+L%3BFortier%2C+KA%3BTomkiewicz%2C+WC+III&rft.aulast=Burson&rft.aufirst=SL&rft.date=2000-06-01&rft.volume=53&rft.issue=2&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Arctic&rft.issn=00040843&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Rangifer tarandus; Ursus arctos; Ovis dalli; Alces alces; Motor vehicles; Population levels; Wildlife; Human impact ER - TY - JOUR T1 - Physiologic determinants of radiation resistance in Deinococcus radiodurans AN - 17550231; 4734181 AB - Immense volumes of radioactive wastes, which were generated during nuclear weapons production, were disposed of directly in the ground during the Cold War, a period when national security priorities often surmounted concerns over the environment. The bacterium Deinococcus radiodurans is the most radiation-resistant organism known and is currently being engineered for remediation of the toxic metal and organic components of these environmental wastes. Understanding the biotic potential of D. radiodurans and its global physiological integrity in nutritionally restricted radioactive environments is important in development of this organism for in situ bioremediation. We have previously shown that D. radiodurans can grow on rich medium in the presence of continuous radiation (6,000 rads/h) without lethality. In this study we developed a chemically defined minimal medium that can be used to analyze growth of this organism in the presence and in the absence of continuous radiation; whereas cell growth was not affected in the absence of radiation, cells did not grow and were killed in the presence of continuous radiation. Under nutrient-limiting conditions, DNA repair was found to be limited by the metabolic capabilities of D. radiodurans and not by any nutritionally induced defect in genetic repair. The results of our growth studies and analysis of the complete D. radiodurans genomic sequence support the hypothesis that there are several defects in D. radiodurans global metabolic regulation that limit carbon, nitrogen, and DNA metabolism. We identified key nutritional constituents that restore growth of D. radiodurans in nutritionally limiting radioactive environments. JF - Applied and Environmental Microbiology AU - Venkateswaran, A AU - McFarlan, S C AU - Ghosal, D AU - Minton, K W AU - Vasilenko, A AU - Makarova, K AU - Wackett, L P AU - Daly, MJ AD - Department of Pathology, Rm. B3153, Uniformed Services University of the Health Sciences (USUHS), 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA, mdaly@usuhs.mil Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 2620 EP - 2626 VL - 66 IS - 6 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Nutrient requirements KW - Growth rate KW - Bioremediation KW - DNA repair KW - Radioresistance KW - Deinococcus radiodurans KW - Media (culture) KW - A 01015:Fermentation & related processes KW - J 02722:Biodegradation, growth, nutrition and leaching UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17550231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Physiologic+determinants+of+radiation+resistance+in+Deinococcus+radiodurans&rft.au=Venkateswaran%2C+A%3BMcFarlan%2C+S+C%3BGhosal%2C+D%3BMinton%2C+K+W%3BVasilenko%2C+A%3BMakarova%2C+K%3BWackett%2C+L+P%3BDaly%2C+MJ&rft.aulast=Venkateswaran&rft.aufirst=A&rft.date=2000-06-01&rft.volume=66&rft.issue=6&rft.spage=2620&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.66.6.2620-2626.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Deinococcus radiodurans; Radioresistance; Bioremediation; Media (culture); Growth rate; DNA repair; Nutrient requirements DO - http://dx.doi.org/10.1128/AEM.66.6.2620-2626.2000 ER - TY - JOUR T1 - The relationship between heavy alcohol use and work productivity loss in active duty military personnel: a secondary analysis of the 1995 Department of Defense Worldwide Survey. AN - 71159327; 10826382 AB - This cross-sectional study examines the association between heavy alcohol use among active duty military personnel and five work productivity loss events that may have an adverse effect on military performance and readiness. Data for light (N = 3,147) and heavy (N = 2,242) drinkers, categorized by gender and pay grade, were obtained from the 1995 Department of Defense Worldwide Survey. Drinking classification was predefined using a standard algorithm that factored quantity and frequency of wine, beer, and liquor consumed. The relative risks of experiencing a productivity loss event at a particular level and 95% confidence intervals were calculated by applying the Mantel-Haenszel method after adjusting for age. The relative risks for increased self-reported lateness, leaving early, low performance, and on-the-job injury were all higher for heavy drinkers than for light drinkers. This association between the heavy-drinking population and four of five work productivity loss events indicates that prevention programs should target all personnel. JF - Military medicine AU - Fisher, C A AU - Hoffman, K J AU - Austin-Lane, J AU - Kao, T C AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-1854, USA. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 355 EP - 361 VL - 165 IS - 5 SN - 0026-4075, 0026-4075 KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Algorithms KW - Smoking -- adverse effects KW - Needs Assessment KW - Salaries and Fringe Benefits -- statistics & numerical data KW - Smoking -- epidemiology KW - Socioeconomic Factors KW - Cross-Sectional Studies KW - Risk Factors KW - Accidents, Occupational -- statistics & numerical data KW - Adult KW - Health Surveys KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Male KW - Alcoholism -- epidemiology KW - Alcoholism -- classification KW - Military Personnel -- statistics & numerical data KW - Efficiency, Organizational -- statistics & numerical data KW - Absenteeism KW - Alcoholism -- prevention & control KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71159327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=The+relationship+between+heavy+alcohol+use+and+work+productivity+loss+in+active+duty+military+personnel%3A+a+secondary+analysis+of+the+1995+Department+of+Defense+Worldwide+Survey.&rft.au=Fisher%2C+C+A%3BHoffman%2C+K+J%3BAustin-Lane%2C+J%3BKao%2C+T+C&rft.aulast=Fisher&rft.aufirst=C&rft.date=2000-05-01&rft.volume=165&rft.issue=5&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-08 N1 - Date created - 2000-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Microbiology of infected poison ivy dermatitis. AN - 71110830; 10809852 AB - We report the aerobic and anaerobic microbiology of secondarily infected poison ivy dermatitis. The study involved retrospective review of clinical and microbiology laboratory records of patients with secondarily infected poison ivy lesions. Bacterial growth was noted in 33 specimens. Aerobic or facultative anaerobic bacteria only were present in 18 (55%) patients, anaerobic bacteria only in seven (21%), and mixed anaerobic-aerobic bacteria in eight (24%). Forty-five isolates were recovered (1.4 per specimen): 27 aerobic or facultative anaerobic bacteria, and 18 strict anaerobes. The predominant aerobic and facultative anaerobic bacteria were Staphylococcus aureus (13 isolates) and group A beta-haemolytic streptococci (six). The predominant anaerobes were Peptostreptococcus spp. (seven isolates), pigmented Prevotella and Porphyromonas spp. (four) and Fusobacterium spp. (two). Single bacterial isolates were recovered in 18 (55%) patients, eight of which were S. aureus. Nineteen of the organisms isolated from 16 (48%) patients produced the enzyme beta-lactamase. Organisms that resided in the mucous membranes close to the lesions predominated in those infections. Enteric gram-negative rods and Bacteroides fragilis group predominated in leg and buttock lesions. Group A beta-haemolytic streptococci, pigmented Prevotella and Porphyromonas and Fusobacterium spp. were most frequently recovered from lesions of the finger, face and neck. The polymicrobial aetiology of secondarily infected poison ivy lesions, and the association of bacterial flora with the anatomical site of the lesions, are demonstrated. JF - The British journal of dermatology AU - Brook, I AU - Frazier, E H AU - Yeager, J K AD - Departments of Paediatrics, Dermatology and Laboratory Medicine, Naval Hospital, Bethesda, MD, USA. brook@mx.afrri.usuhs.mil Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 943 EP - 946 VL - 142 IS - 5 SN - 0007-0963, 0007-0963 KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Porphyromonas -- metabolism KW - Bacteroides fragilis -- isolation & purification KW - Staphylococcus aureus -- isolation & purification KW - Bacteroides fragilis -- metabolism KW - Humans KW - Streptococcus -- isolation & purification KW - Retrospective Studies KW - Prevotella -- isolation & purification KW - Peptostreptococcus -- isolation & purification KW - Streptococcus -- metabolism KW - Staphylococcus aureus -- metabolism KW - Peptostreptococcus -- metabolism KW - Porphyromonas -- isolation & purification KW - beta-Lactamases -- biosynthesis KW - Fusobacterium -- metabolism KW - Prevotella -- metabolism KW - Fusobacterium -- isolation & purification KW - Bacterial Infections KW - Skin Diseases, Bacterial -- microbiology KW - Dermatitis, Toxicodendron -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71110830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+dermatology&rft.atitle=Microbiology+of+infected+poison+ivy+dermatitis.&rft.au=Brook%2C+I%3BFrazier%2C+E+H%3BYeager%2C+J+K&rft.aulast=Brook&rft.aufirst=I&rft.date=2000-05-01&rft.volume=142&rft.issue=5&rft.spage=943&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+dermatology&rft.issn=00070963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-29 N1 - Date created - 2000-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A 1500-year record of accumulation at Amundsen, western Dronning Maud Land, Antarctica, derived from electrical and radioactive measurements on a 120 m ice core AN - 52147548; 2002-016855 JF - Abstracts from the Arctic Forum AU - Karlof, Lars AU - Winther, Jan-Gunnar AU - Isaksson, Elisabeth AU - Kohler, Jack AU - Pinglot, J Francis AU - Wilhelms, Frank AU - Hansson, Margareta AU - Holmland, Per AU - Nuyman, Mart AU - Pettersson, Rickard AU - Stenberg, Malin AU - Thomasson, Martijn P A AU - van der Veen, Carina AU - van de Wal, Roderik S AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 51 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - ice cores KW - electrical conductivity KW - Quaternary KW - geophysical surveys KW - radioactivity KW - geophysical methods KW - electrical methods KW - Queen Maud Land KW - Holocene KW - Amundsen Station KW - Cenozoic KW - Antarctica KW - surveys KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52147548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=A+1500-year+record+of+accumulation+at+Amundsen%2C+western+Dronning+Maud+Land%2C+Antarctica%2C+derived+from+electrical+and+radioactive+measurements+on+a+120+m+ice+core&rft.au=Karlof%2C+Lars%3BWinther%2C+Jan-Gunnar%3BIsaksson%2C+Elisabeth%3BKohler%2C+Jack%3BPinglot%2C+J+Francis%3BWilhelms%2C+Frank%3BHansson%2C+Margareta%3BHolmland%2C+Per%3BNuyman%2C+Mart%3BPettersson%2C+Rickard%3BStenberg%2C+Malin%3BThomasson%2C+Martijn+P+A%3Bvan+der+Veen%2C+Carina%3Bvan+de+Wal%2C+Roderik+S%3BMaslowski%2C+Wieslaw&rft.aulast=Karlof&rft.aufirst=Lars&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Amundsen Station; Antarctica; Cenozoic; electrical conductivity; electrical methods; geophysical methods; geophysical surveys; Holocene; ice cores; Quaternary; Queen Maud Land; radioactivity; surveys ER - TY - JOUR T1 - Distribution of delta (super 13) C in sediment organic carbon, Arctic Amerasian continental margin AN - 52147505; 2002-016849 JF - Abstracts from the Arctic Forum AU - Naidu, A Sathy AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 16 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - North America KW - continental margin KW - isotopes KW - isotope ratios KW - Arctic region KW - C-13/C-12 KW - stable isotopes KW - marine sediments KW - carbon KW - sediments KW - organic carbon KW - chemical composition KW - Asia KW - 02D:Isotope geochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52147505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Distribution+of+delta+%28super+13%29+C+in+sediment+organic+carbon%2C+Arctic+Amerasian+continental+margin&rft.au=Naidu%2C+A+Sathy%3BMaslowski%2C+Wieslaw&rft.aulast=Naidu&rft.aufirst=A&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 1 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Arctic region; Asia; C-13/C-12; carbon; chemical composition; continental margin; isotope ratios; isotopes; marine sediments; North America; organic carbon; sediments; stable isotopes ER - TY - JOUR T1 - The new "Lithostratigraphic Lexicon of Svalbard" AN - 52146765; 2002-016854 JF - Abstracts from the Arctic Forum AU - Dallmann, Winfried AU - Mork, Atle AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 42 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - nomenclature KW - lithostratigraphy KW - Svalbard KW - Arctic region KW - lexicons KW - 12:Stratigraphy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52146765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=The+new+%22Lithostratigraphic+Lexicon+of+Svalbard%22&rft.au=Dallmann%2C+Winfried%3BMork%2C+Atle%3BMaslowski%2C+Wieslaw&rft.aulast=Dallmann&rft.aufirst=Winfried&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 1 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Arctic region; lexicons; lithostratigraphy; nomenclature; Svalbard ER - TY - JOUR T1 - The role of thermal regime in glacier hydrology and dynamics in an arctic polythermal glacier AN - 52146043; 2002-016862 JF - Abstracts from the Arctic Forum AU - Rippin, David M AU - Arnold, Neil S AU - Willis, Ian C AU - Hodson, Andrew AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 69 EP - 70 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - hydrology KW - Svalbard KW - Midre Lovenbreen KW - Arctic region KW - glaciers KW - Spitsbergen KW - glacial geology KW - thermal regime KW - climate change KW - 24:Quaternary geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52146043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=The+role+of+thermal+regime+in+glacier+hydrology+and+dynamics+in+an+arctic+polythermal+glacier&rft.au=Rippin%2C+David+M%3BArnold%2C+Neil+S%3BWillis%2C+Ian+C%3BHodson%2C+Andrew%3BMaslowski%2C+Wieslaw&rft.aulast=Rippin&rft.aufirst=David&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Arctic region; climate change; glacial geology; glaciers; hydrology; Midre Lovenbreen; Spitsbergen; Svalbard; thermal regime ER - TY - JOUR T1 - Seasonal and long-term variability of the sea level in the marginal seas of the Arctic Ocean AN - 52146004; 2002-016859 JF - Abstracts from the Arctic Forum AU - Pavlov, Vladimir K AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 66 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - polar regions KW - ocean circulation KW - East Siberian Sea KW - climate change KW - thermohaline circulation KW - sea-level changes KW - Chukchi Sea KW - Kara Sea KW - Polar Continental Shelf KW - Laptev Sea KW - Arctic Ocean KW - seasonal variations KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52146004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Seasonal+and+long-term+variability+of+the+sea+level+in+the+marginal+seas+of+the+Arctic+Ocean&rft.au=Pavlov%2C+Vladimir+K%3BMaslowski%2C+Wieslaw&rft.aulast=Pavlov&rft.aufirst=Vladimir&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Arctic Ocean; Chukchi Sea; climate change; East Siberian Sea; Kara Sea; Laptev Sea; ocean circulation; Polar Continental Shelf; polar regions; sea-level changes; seasonal variations; thermohaline circulation ER - TY - JOUR T1 - Estimates of water and solute diffusion in frozen ground utilizing pulsed-field-gradient nuclear magnetic resonance AN - 52144218; 2002-016863 JF - Abstracts from the Arctic Forum AU - Sletten, Ronald S AU - Pratum, Thomas P AU - Grant, Steven A AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 72 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - soils KW - diffusion KW - permafrost KW - solutes KW - water regimes KW - spectra KW - frozen ground KW - NMR spectra KW - ground water KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52144218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Estimates+of+water+and+solute+diffusion+in+frozen+ground+utilizing+pulsed-field-gradient+nuclear+magnetic+resonance&rft.au=Sletten%2C+Ronald+S%3BPratum%2C+Thomas+P%3BGrant%2C+Steven+A%3BMaslowski%2C+Wieslaw&rft.aulast=Sletten&rft.aufirst=Ronald&rft.date=2000-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Determinants+of+ethnogenetic+processes+of+Asian+Indians+in+the+United+States&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - diffusion; frozen ground; ground water; NMR spectra; permafrost; soils; solutes; spectra; water regimes ER - TY - JOUR T1 - Hydrogeochemistry and microbiology in subarctic ground water; implications for natural attenuation of trichloroethene AN - 52144181; 2002-016861 JF - Abstracts from the Arctic Forum AU - Richmond, Sharon A AU - Braddock, Joan F AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 68 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - United States KW - chlorinated hydrocarbons KW - Fairbanks Alaska KW - pollutants KW - biochemistry KW - pollution KW - subarctic regions KW - environmental analysis KW - ground water KW - organic compounds KW - East-Central Alaska KW - halogenated hydrocarbons KW - Alaska KW - trichloroethylene KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52144181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Hydrogeochemistry+and+microbiology+in+subarctic+ground+water%3B+implications+for+natural+attenuation+of+trichloroethene&rft.au=Richmond%2C+Sharon+A%3BBraddock%2C+Joan+F%3BMaslowski%2C+Wieslaw&rft.aulast=Richmond&rft.aufirst=Sharon&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 1 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Alaska; biochemistry; chlorinated hydrocarbons; East-Central Alaska; environmental analysis; Fairbanks Alaska; ground water; halogenated hydrocarbons; organic compounds; pollutants; pollution; subarctic regions; trichloroethylene; United States ER - TY - JOUR T1 - Magma storage and mixing conditions for the 1953-74 eruption of southwest Trident Volcano, Katmai National Park, Alaska AN - 52143966; 2002-016850 JF - Abstracts from the Arctic Forum AU - Coombs, Michelle AU - Eichelberger, John C AU - Rutherford, Malcolm J AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 20 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - United States KW - Trident KW - magmatism KW - mineral composition KW - volcanism KW - mixing KW - eruptions KW - volcanoes KW - Katmai National Park KW - Alaska KW - Southwestern Alaska KW - chemical composition KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52143966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Magma+storage+and+mixing+conditions+for+the+1953-74+eruption+of+southwest+Trident+Volcano%2C+Katmai+National+Park%2C+Alaska&rft.au=Coombs%2C+Michelle%3BEichelberger%2C+John+C%3BRutherford%2C+Malcolm+J%3BMaslowski%2C+Wieslaw&rft.aulast=Coombs&rft.aufirst=Michelle&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Alaska; chemical composition; eruptions; Katmai National Park; magmatism; mineral composition; mixing; Southwestern Alaska; Trident; United States; volcanism; volcanoes ER - TY - JOUR T1 - A new environmental initiative for NSF and advances in climate modeling of the Arctic AN - 52143831; 2002-016846 JF - Abstracts from the Arctic Forum AU - Washington, Warren M AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 2 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - models KW - polar regions KW - human activity KW - government agencies KW - Arctic Ocean KW - global change KW - ecology KW - NSF KW - climate change KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52143831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=A+new+environmental+initiative+for+NSF+and+advances+in+climate+modeling+of+the+Arctic&rft.au=Washington%2C+Warren+M%3BMaslowski%2C+Wieslaw&rft.aulast=Washington&rft.aufirst=Warren&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Arctic Ocean; climate change; ecology; global change; government agencies; human activity; models; NSF; polar regions ER - TY - JOUR T1 - Annual water balance for three nested watersheds on the North Slope of Alaska AN - 52143466; 2002-016857 JF - Abstracts from the Arctic Forum AU - Lilly, Elizabeth K AU - Kane, Douglas L AU - Hinzman, Larry D AU - Gieck, Robert E AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 53 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - United States KW - permafrost KW - North Slope KW - annual variations KW - Arctic region KW - Northern Alaska KW - watersheds KW - Alaska KW - water balance KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52143466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Annual+water+balance+for+three+nested+watersheds+on+the+North+Slope+of+Alaska&rft.au=Lilly%2C+Elizabeth+K%3BKane%2C+Douglas+L%3BHinzman%2C+Larry+D%3BGieck%2C+Robert+E%3BMaslowski%2C+Wieslaw&rft.aulast=Lilly&rft.aufirst=Elizabeth&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Alaska; annual variations; Arctic region; North Slope; Northern Alaska; permafrost; United States; water balance; watersheds ER - TY - JOUR T1 - Implications of N (super *) distributions for sedimentary denitrification rates in Antarctica and the Arctic AN - 52143434; 2002-016853 JF - Abstracts from the Arctic Forum AU - Codispoti, Louis A AU - Cota, Glenn F AU - Gaurin, Steven E AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 41 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - Southern Ocean KW - polar regions KW - Arctic region KW - Antarctic Ocean KW - marine sediments KW - Antarctica KW - Polar Continental Shelf KW - denitrification KW - Ross Sea KW - sediments KW - Arctic Ocean KW - chemical composition KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52143434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Implications+of+N+%28super+*%29+distributions+for+sedimentary+denitrification+rates+in+Antarctica+and+the+Arctic&rft.au=Codispoti%2C+Louis+A%3BCota%2C+Glenn+F%3BGaurin%2C+Steven+E%3BMaslowski%2C+Wieslaw&rft.aulast=Codispoti&rft.aufirst=Louis&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 3 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Antarctic Ocean; Antarctica; Arctic Ocean; Arctic region; chemical composition; denitrification; marine sediments; Polar Continental Shelf; polar regions; Ross Sea; sediments; Southern Ocean ER - TY - JOUR T1 - BERPAC; a long-term ecological research program of the Bering and Chukchi seas and Pacific Ocean AN - 52143091; 2002-016864 JF - Abstracts from the Arctic Forum AU - Smith, Gregory A AU - Grebmeier, Jacqueline M AU - Kohl, Steven AU - Tsyban, Alla V AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 73 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - Bering Sea KW - international cooperation KW - global change KW - ecosystems KW - current research KW - climate change KW - Chukchi Sea KW - BERPAC KW - North Pacific KW - Pacific Ocean KW - Arctic Ocean KW - ecology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52143091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=BERPAC%3B+a+long-term+ecological+research+program+of+the+Bering+and+Chukchi+seas+and+Pacific+Ocean&rft.au=Smith%2C+Gregory+A%3BGrebmeier%2C+Jacqueline+M%3BKohl%2C+Steven%3BTsyban%2C+Alla+V%3BMaslowski%2C+Wieslaw&rft.aulast=Smith&rft.aufirst=Gregory&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Arctic Ocean; Bering Sea; BERPAC; Chukchi Sea; climate change; current research; ecology; ecosystems; global change; international cooperation; North Pacific; Pacific Ocean ER - TY - JOUR T1 - Seafloor Characterization and Mapping Pods (SCAMP); recent results from SCICEX AN - 52143066; 2002-016852 JF - Abstracts from the Arctic Forum AU - Chayes, Dale N AU - Edwards, Margo AU - Coakley, Bernard J AU - Anderson, Robert M AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 39 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - geophysical surveys KW - Mid-Arctic Ocean Ridge KW - geophysical methods KW - gravity methods KW - acoustical methods KW - Chukchi Sea KW - Northwind Ridge KW - surveys KW - Arctic Ocean KW - ocean floors KW - sonar methods KW - mid-ocean ridges KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52143066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Seafloor+Characterization+and+Mapping+Pods+%28SCAMP%29%3B+recent+results+from+SCICEX&rft.au=Chayes%2C+Dale+N%3BEdwards%2C+Margo%3BCoakley%2C+Bernard+J%3BAnderson%2C+Robert+M%3BMaslowski%2C+Wieslaw&rft.aulast=Chayes&rft.aufirst=Dale&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - acoustical methods; Arctic Ocean; Chukchi Sea; geophysical methods; geophysical surveys; gravity methods; Mid-Arctic Ocean Ridge; mid-ocean ridges; Northwind Ridge; ocean floors; sonar methods; surveys ER - TY - JOUR T1 - Remote sensing of landscape degradation around the Noril'sk factories in northern Siberia AN - 52142532; 2002-016860 JF - Abstracts from the Arctic Forum AU - Rees, Gareth AU - Toutoubalina, Olga AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 67 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - sulfur dioxide KW - Taymyr Dolgan-Nenets Russian Federation KW - degradation KW - pollutants KW - pollution KW - Russian Federation KW - vegetation KW - satellite methods KW - environmental analysis KW - Krasnoyarsk Russian Federation KW - Siberia KW - Commonwealth of Independent States KW - Asia KW - Norilsk Russian Federation KW - remote sensing KW - 20:Applied geophysics KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Remote+sensing+of+landscape+degradation+around+the+Noril%27sk+factories+in+northern+Siberia&rft.au=Rees%2C+Gareth%3BToutoubalina%2C+Olga%3BMaslowski%2C+Wieslaw&rft.aulast=Rees&rft.aufirst=Gareth&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Asia; Commonwealth of Independent States; degradation; environmental analysis; Krasnoyarsk Russian Federation; Norilsk Russian Federation; pollutants; pollution; remote sensing; Russian Federation; satellite methods; Siberia; sulfur dioxide; Taymyr Dolgan-Nenets Russian Federation; vegetation ER - TY - JOUR T1 - Teachers experiencing the Antarctic and Arctic-TEA AN - 52142487; 2002-016858 JF - Abstracts from the Arctic Forum AU - Meese, Debra AU - Shipp, Stephanie AU - Yentsch, Clarice AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 58 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - K-12 education KW - Antarctica KW - Arctic region KW - Arctic Ocean KW - education KW - research KW - teacher education KW - 15:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52142487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Teachers+experiencing+the+Antarctic+and+Arctic-TEA&rft.au=Meese%2C+Debra%3BShipp%2C+Stephanie%3BYentsch%2C+Clarice%3BMaslowski%2C+Wieslaw&rft.aulast=Meese&rft.aufirst=Debra&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Antarctica; Arctic Ocean; Arctic region; education; K-12 education; research; teacher education ER - TY - JOUR T1 - Living on the edge; archaeology and coastal dynamics along the Gulf of Alaska coast AN - 52141998; 2002-016851 JF - Abstracts from the Arctic Forum AU - Crowell, Aron L AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 25 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - United States KW - East Pacific KW - archaeology KW - anthropology KW - Quaternary KW - Northeast Pacific KW - Holocene KW - Southern Alaska KW - Cenozoic KW - North Pacific KW - Gulf of Alaska KW - Pacific Ocean KW - coastal environment KW - Alaska KW - 24:Quaternary geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52141998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Living+on+the+edge%3B+archaeology+and+coastal+dynamics+along+the+Gulf+of+Alaska+coast&rft.au=Crowell%2C+Aron+L%3BMaslowski%2C+Wieslaw&rft.aulast=Crowell&rft.aufirst=Aron&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Alaska; anthropology; archaeology; Cenozoic; coastal environment; East Pacific; Gulf of Alaska; Holocene; North Pacific; Northeast Pacific; Pacific Ocean; Quaternary; Southern Alaska; United States ER - TY - JOUR T1 - Streamflow modeling in an Alaskan watershed underlain by permafrost AN - 52140628; 2002-016856 JF - Abstracts from the Arctic Forum AU - Knudson, Julie A AU - Hinzman, Larry D AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 52 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - United States KW - models KW - Fairbanks Alaska KW - permafrost KW - streamflow KW - East-Central Alaska KW - rivers and streams KW - watersheds KW - Alaska KW - subarctic regions KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52140628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Streamflow+modeling+in+an+Alaskan+watershed+underlain+by+permafrost&rft.au=Knudson%2C+Julie+A%3BHinzman%2C+Larry+D%3BMaslowski%2C+Wieslaw&rft.aulast=Knudson&rft.aufirst=Julie&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Alaska; East-Central Alaska; Fairbanks Alaska; models; permafrost; rivers and streams; streamflow; subarctic regions; United States; watersheds ER - TY - JOUR T1 - Decadal variability of the Greenland ice sheet mass balance as a cause of the "Great Salinity Anomalies" in the northern North Atlantic AN - 51340633; 2002-016847 JF - Abstracts from the Arctic Forum AU - Belkin, Igor M AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 12 EP - 13 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - sea water KW - icebergs KW - annual variations KW - Arctic region KW - sea ice KW - Greenland ice sheet KW - salinity KW - ice sheets KW - Greenland KW - mass balance KW - ice KW - glacial geology KW - North Atlantic KW - Atlantic Ocean KW - 24:Quaternary geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51340633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Decadal+variability+of+the+Greenland+ice+sheet+mass+balance+as+a+cause+of+the+%22Great+Salinity+Anomalies%22+in+the+northern+North+Atlantic&rft.au=Belkin%2C+Igor+M%3BMaslowski%2C+Wieslaw&rft.aulast=Belkin&rft.aufirst=Igor&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 1 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - annual variations; Arctic region; Atlantic Ocean; glacial geology; Greenland; Greenland ice sheet; ice; ice sheets; icebergs; mass balance; North Atlantic; salinity; sea ice; sea water ER - TY - JOUR T1 - Millennial-scale global events recorded in El'gygytgyn Crater Lake, eastern Siberia back to 400 ka AN - 50296152; 2002-016848 JF - Abstracts from the Arctic Forum AU - Brigham-Grette, Julie AU - Glushkova, Olga AU - Minyuk, Paul AU - Melles, Martin AU - Nowaczyk, Norbert R AU - Lozhkin, A V AU - Anderson, Patricia AU - Cherepanov, M V AU - Cosby, C AU - Layer, Paul AU - Forman, Steve L AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 14 EP - 15 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - Quaternary KW - impactites KW - impact features KW - Arctic region KW - global change KW - Russian Federation KW - Cenozoic KW - Siberia KW - Commonwealth of Independent States KW - metamorphic rocks KW - impact craters KW - El'gygytgyn Lake KW - Asia KW - 24:Quaternary geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50296152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Millennial-scale+global+events+recorded+in+El%27gygytgyn+Crater+Lake%2C+eastern+Siberia+back+to+400+ka&rft.au=Brigham-Grette%2C+Julie%3BGlushkova%2C+Olga%3BMinyuk%2C+Paul%3BMelles%2C+Martin%3BNowaczyk%2C+Norbert+R%3BLozhkin%2C+A+V%3BAnderson%2C+Patricia%3BCherepanov%2C+M+V%3BCosby%2C+C%3BLayer%2C+Paul%3BForman%2C+Steve+L%3BMaslowski%2C+Wieslaw&rft.aulast=Brigham-Grette&rft.aufirst=Julie&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 4 N1 - PubXState - AK N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Arctic region; Asia; Cenozoic; Commonwealth of Independent States; El'gygytgyn Lake; global change; impact craters; impact features; impactites; metamorphic rocks; Quaternary; Russian Federation; Siberia ER - TY - JOUR T1 - Arctic forum 2000 AN - 50084149; 2002-016845 JF - Abstracts from the Arctic Forum AU - Maslowski, Wieslaw Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 97 PB - Arctic Research Consortium of the U. S. (ARCUS), Fairbanks, AK VL - 2000 KW - symposia KW - Arctic region KW - Arctic Ocean KW - research KW - 15:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50084149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Abstracts+from+the+Arctic+Forum&rft.atitle=Arctic+forum+2000&rft.au=Maslowski%2C+Wieslaw&rft.aulast=Maslowski&rft.aufirst=Wieslaw&rft.date=2000-05-01&rft.volume=2000&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Abstracts+from+the+Arctic+Forum&rft.issn=&rft_id=info:doi/ L2 - http://www.arcus.org/annual_meetings/arctic_forum_online.html LA - English DB - GeoRef N1 - Conference title - Arctic forum 2000 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - AK N1 - SuppNotes - Individual abstracts within scope are cited separately N1 - Last updated - 2012-06-07 N1 - CODEN - #05001 N1 - SubjectsTermNotLitGenreText - Arctic Ocean; Arctic region; research; symposia ER - TY - JOUR T1 - p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex. AN - 71031199; 10766811 AB - The human T-cell lymphotropic virus, type (HTLV)-1 trans-activator, Tax, coordinates with cAMP-responsive element-binding protein (CREB) and the transcriptional co-activators p300/CBP on three 21-base pair repeat elements in the proviral long terminal repeat (LTR) to promote viral mRNA transcription. Recruitment of p300/CBP to the activator-enhancer complex, however, is insufficient to support Tax-dependent LTR trans-activation. Here, we report that the p300/CBP-associated factor (P/CAF) is a critical and integral component of the functional HTLV-1 activator-enhancer complex. The HTLV-1 Tax protein directly binds P/CAF in vitro and co-immunoprecipitates with this co-activator in vivo. The Tax mutants (K88A and V89A) defective for p300/CBP-binding and LTR trans-activation, retained their abilities to interact with P/CAF. The M47 mutant (L319R, L320S) protein, which has previously been shown to interact with p300/CBP, by contrast, failed to form complexes with P/CAF and is impaired in LTR trans-activation. Furthermore, LTR trans-activation by Tax is competitively inhibited by the adenoviral E1A 12S gene product, which displaces P/CAF from p300/CBP and inhibits the histone acetyltransferase activities of both P/CAF and p300/CBP. This inhibition is partially reversed by exogenously added P/CAF. These results imply that simultaneous recruitment of two distinct co-activators (p300/CBP and P/CAF) by Tax is essential for the assembly of a trans-activation competent, nucleoprotein complex. JF - The Journal of biological chemistry AU - Harrod, R AU - Kuo, Y L AU - Tang, Y AU - Yao, Y AU - Vassilev, A AU - Nakatani, Y AU - Giam, C Z AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 2000/04/21/ PY - 2000 DA - 2000 Apr 21 SP - 11852 EP - 11857 VL - 275 IS - 16 SN - 0021-9258, 0021-9258 KW - Cell Cycle Proteins KW - 0 KW - Gene Products, tax KW - Nuclear Proteins KW - Trans-Activators KW - Transcription Factors KW - Acetyltransferases KW - EC 2.3.1.- KW - Histone Acetyltransferases KW - EC 2.3.1.48 KW - NCOA3 protein, human KW - Nuclear Receptor Coactivator 3 KW - p300-CBP Transcription Factors KW - p300-CBP-associated factor KW - Index Medicus KW - AIDS/HIV KW - Transfection KW - HeLa Cells KW - Acetyltransferases -- metabolism KW - Humans KW - Terminal Repeat Sequences KW - Mutagenesis KW - Cell Cycle Proteins -- metabolism KW - Trans-Activators -- metabolism KW - Gene Products, tax -- metabolism KW - Human T-lymphotropic virus 1 KW - Nuclear Proteins -- metabolism KW - Transcriptional Activation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71031199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=p300+and+p300%2FcAMP-responsive+element-binding+protein+associated+factor+interact+with+human+T-cell+lymphotropic+virus+type-1+Tax+in+a+multi-histone+acetyltransferase%2Factivator-enhancer+complex.&rft.au=Harrod%2C+R%3BKuo%2C+Y+L%3BTang%2C+Y%3BYao%2C+Y%3BVassilev%2C+A%3BNakatani%2C+Y%3BGiam%2C+C+Z&rft.aulast=Harrod&rft.aufirst=R&rft.date=2000-04-21&rft.volume=275&rft.issue=16&rft.spage=11852&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-10 N1 - Date created - 2000-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cautery-assisted palatal stiffening operation. AN - 85339653; pmid-10740176 AB - Outpatient surgical therapy of habitual snoring and mild obstructive sleep apnea has evolved significantly in recent years. We introduce the cautery-assisted palatal stiffening operation (CAPSO) and detail its important advantages over uvulopalatopharyngoplasty, laser-assisted uvulopalatoplasty, and palatal radiofrequency ablation. CAPSO is critically analyzed with regard to extent of surgery, need for repetition of procedure, results, complications, predictors of success, and cost analysis. CAPSO is a mucosal surgery that induces a midline palatal scar that stiffens the floppy palate. Two hundred six consecutive patients underwent CAPSO over an 18-month period, followed by office examination and telephone evaluation. The success rate was initially 92% and dipped to 77% after 1 year. CAPSO eliminates excessive snoring caused by palatal flutter and has success rates that were comparable with those of traditional palatal surgery. CAPSO is a simple and safe office procedure that avoids the need for multiple-stage operations and does not rely on expensive laser systems or radiofrequency generators and hand pieces. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Mair, E A AU - Day, R H AD - Uniformed Services University of the Health Sciences, Washington DC, USA. Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 547 EP - 556 VL - 122 IS - 4 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Prospective Studies KW - Humans KW - Adult KW - Ambulatory Surgical Procedures KW - Treatment Outcome KW - Follow-Up Studies KW - Snoring -- surgery KW - Palate -- surgery KW - Cautery -- methods KW - Sleep Apnea, Obstructive -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85339653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Cautery-assisted+palatal+stiffening+operation.&rft.au=Mair%2C+E+A%3BDay%2C+R+H&rft.aulast=Mair&rft.aufirst=E&rft.date=2000-04-01&rft.volume=122&rft.issue=4&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Estrogen-progestin increases breast cancer risk. AN - 71091012; 10778832 JF - The Journal of family practice AU - Stephens, M B AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. mstephens@usuhs.mil Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 301 EP - 302 VL - 49 IS - 4 SN - 0094-3509, 0094-3509 KW - Estrogens KW - 0 KW - Progestins KW - Abridged Index Medicus KW - Index Medicus KW - Risk KW - Humans KW - Middle Aged KW - Female KW - Risk Assessment KW - Estrogen Replacement Therapy -- adverse effects KW - Progestins -- adverse effects KW - Progestins -- administration & dosage KW - Breast Neoplasms -- epidemiology KW - Estrogens -- adverse effects KW - Estrogens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71091012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+family+practice&rft.atitle=Estrogen-progestin+increases+breast+cancer+risk.&rft.au=Stephens%2C+M+B&rft.aulast=Stephens&rft.aufirst=M&rft.date=2000-04-01&rft.volume=49&rft.issue=4&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+family+practice&rft.issn=00943509&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-04 N1 - Date created - 2000-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Military Reform and Strategic Nuclear Forces of the Russian Federation AN - 60589466; 200106579 AB - Russian Minister of Defense Marshal Igor Sergeyev has proposed merging the Strategic Rocket Forces & strategic nuclear components of the Navy & Air Force. Advocates of the proposed reform invoke Russia's need to increase its reliance on nuclear weapons in view of the decline in its conventional forces, as well the potential savings from the merger. Critics of the plan view it as favoring the Strategic Rocket Forces at the expense of the rest of the military & as prohibitively expensive. The NATO campaign in Kosovo has made Marshal Sergeyev vulnerable to criticism for emphasizing nuclear forces over conventional ones, & the plan has been put on hold. 2 Figures. Adapted from the source document. JF - European Security AU - Tsypkin, Mikhail AD - Dept National Security Affairs, US Naval Postgraduate School, Monterey, CA Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 22 EP - 40 VL - 9 IS - 1 SN - 0966-2839, 0966-2839 KW - Russia KW - Foreign Policy KW - Organizational Change KW - Armed Forces KW - National Security KW - Nuclear Weapons KW - article KW - 9091: government/political systems; armed forces UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60589466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Security&rft.atitle=Military+Reform+and+Strategic+Nuclear+Forces+of+the+Russian+Federation&rft.au=Tsypkin%2C+Mikhail&rft.aulast=Tsypkin&rft.aufirst=Mikhail&rft.date=2000-04-01&rft.volume=9&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=European+Security&rft.issn=09662839&rft_id=info:doi/ LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - National Security; Armed Forces; Organizational Change; Nuclear Weapons; Foreign Policy; Russia ER - TY - JOUR T1 - Researchers explore Arctic freshwater's role in ocean circulation AN - 52361140; 2000-036316 JF - Eos, Transactions, American Geophysical Union AU - Forman, Steven L AU - Maslowski, Wieslaw AU - Andrews, John T AU - Lubinski, David AU - Steele, Michael AU - Zhang, Jain AU - Lammers, Richard AU - Peterson, Bruce Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 169 EP - 169, 174 PB - American Geophysical Union, Washington, DC VL - 81 IS - 16 SN - 0096-3941, 0096-3941 KW - hydrology KW - currents KW - ocean circulation KW - last glacial maximum KW - Bering Strait KW - global KW - drainage KW - watersheds KW - fresh water KW - water balance KW - rivers KW - ocean currents KW - ice sheets KW - models KW - fluvial features KW - climate effects KW - Arctic Ocean KW - glacial geology KW - continental shelf KW - bathymetry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52361140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Researchers+explore+Arctic+freshwater%27s+role+in+ocean+circulation&rft.au=Forman%2C+Steven+L%3BMaslowski%2C+Wieslaw%3BAndrews%2C+John+T%3BLubinski%2C+David%3BSteele%2C+Michael%3BZhang%2C+Jain%3BLammers%2C+Richard%3BPeterson%2C+Bruce&rft.aulast=Forman&rft.aufirst=Steven&rft.date=2000-04-01&rft.volume=81&rft.issue=16&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 10 N1 - PubXState - DC N1 - Document feature - illus. incl. geol. sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Arctic Ocean; bathymetry; Bering Strait; climate effects; continental shelf; currents; drainage; fluvial features; fresh water; glacial geology; global; hydrology; ice sheets; last glacial maximum; models; ocean circulation; ocean currents; rivers; water balance; watersheds ER - TY - JOUR T1 - Velocity moments in alongshore bottom stress parameterizations AN - 51017687; 2002-018929 JF - Journal of Geophysical Research AU - Feddersen, Falk AU - Guza, R T AU - Elgar, Steve AU - Herbers, T H C Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 8673 EP - 8686 PB - American Geophysical Union, Washington, DC VL - 105 IS - C4 SN - 0148-0227, 0148-0227 KW - models KW - alongshore bottom stress KW - ocean circulation KW - factors KW - stress KW - velocity KW - coastal environment KW - mean alongshore currents KW - ocean floors KW - nearshore environment KW - variations KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51017687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Velocity+moments+in+alongshore+bottom+stress+parameterizations&rft.au=Feddersen%2C+Falk%3BGuza%2C+R+T%3BElgar%2C+Steve%3BHerbers%2C+T+H+C&rft.aulast=Feddersen&rft.aufirst=Falk&rft.date=2000-04-01&rft.volume=105&rft.issue=C4&rft.spage=8673&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2000JC900022 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 33 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - alongshore bottom stress; coastal environment; factors; mean alongshore currents; models; nearshore environment; ocean circulation; ocean floors; stress; variations; velocity DO - http://dx.doi.org/10.1029/2000JC900022 ER - TY - JOUR T1 - A view of the 1993-1994 California Current based on surface drifters, floats, and remotely sensed data AN - 50158988; 2002-018924 AB - Near-surface drifters were deployed in the California Current System during the period 1993-1994 in order to study mean and eddy currents. The deployment scheme allowed a 2 year period where data density was high enough to make meaningful estimates of eddy statistics and of seasonal mean currents and variances on a 5 degrees grid. Eddy variability, which tended to be isotropic, was higher near the coast (standard deviations around 0.2 m s (super -1) ) and decreased offshore (down to approximately 0.1 m s (super -1) ). Seasonal mean surface flow west of California was southward during all seasons: if a Davidson Current existed during 1993-1995, it was probably either short-lived or only found closer to the coast than our study area, i.e., within 100-150 km of shore. In some cases, drifter populations within a discrete feature were high enough to allow some detailed resolution of its behavior. We note a tendency for individual eddies (which can last for up to 3-5 months) to drift westward at rates of O(5 km day (super -1) ). Not all eddies in the region are surface-intensified. There is clear evidence for at least the occasional presence of a thin, meandering southward jet in the region that can be 1000 km or more long. This jet can be identified with that found in the Coastal Transition Zone program in association with cool filaments. The jet appears to become broader and slower south of Point Conception. We hypothesize (on the basis of others' results as well as ours) that the eddies that are strongest at the surface result primarily from instabilities on a southward alongshore mean current and that eddies that are maximal at depth are spawned by the northward undercurrent. Copyright 2000 by the American Geophysical Union. JF - Journal of Geophysical Research AU - Brink, K H AU - Beardsley, R C AU - Paduan, J AU - Limeburner, R AU - Caruso, M AU - Sires, J G Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 8575 EP - 8604 PB - American Geophysical Union, Washington, DC VL - 105 IS - C4 SN - 0148-0227, 0148-0227 KW - East Pacific KW - currents KW - ocean circulation KW - Davidson Current KW - California Current KW - Eastern Boundary Current KW - statistical analysis KW - altimetry KW - satellite methods KW - ocean currents KW - eddies KW - Pacific Ocean KW - ocean waves KW - seasonal variations KW - surface drifters KW - remote sensing KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50158988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=A+view+of+the+1993-1994+California+Current+based+on+surface+drifters%2C+floats%2C+and+remotely+sensed+data&rft.au=Brink%2C+K+H%3BBeardsley%2C+R+C%3BPaduan%2C+J%3BLimeburner%2C+R%3BCaruso%2C+M%3BSires%2C+J+G&rft.aulast=Brink&rft.aufirst=K&rft.date=2000-04-01&rft.volume=105&rft.issue=C4&rft.spage=8575&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F1999JC900327 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 47 N1 - PubXState - DC N1 - Document feature - illus. incl. 11 plates, 4 tables, geol. sketch maps N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - altimetry; California Current; currents; Davidson Current; East Pacific; Eastern Boundary Current; eddies; ocean circulation; ocean currents; ocean waves; Pacific Ocean; remote sensing; satellite methods; seasonal variations; statistical analysis; surface drifters DO - http://dx.doi.org/10.1029/1999JC900327 ER - TY - JOUR T1 - Patellofemoral pain syndrome in the female athlete. AN - 18142561; 4867590 AB - Although PFS will continue to be a therapeutic challenge, the prognosis for most female athletes is good, especially if they are motivated and compliant with their treatment program. Particularly in women, care should be taken to avoid placing too much emphasis on biomechanical variants that may not be clinically significant or correctable because such findings can reinforce a feeling that "nothing can be done." In many cases, muscle dysfunction and repetitive loading of the patellofemoral joint rather than fixed biomechanical factors contribute to the development of PFS. Nonetheless, the importance of a detailed biomechanical assessment on physical examination must not be neglected, particularly in athletes who are not improving with conservative treatment and who may become surgical candidates. A practical initial treatment program for most athletes with nontraumatic PFS begins with relative rest, quadriceps strengthening, and stretching of tight myotendinous units. The introduction of NSAIDs, orthoses, taping, knee sleeves, and more specific rehabilitative exercises should be an individualized decision based on physical findings, past treatment results, and athletic expectations. Surgical referral should be considered in cases of PFS or patellar instability refractory to prolonged maximal nonoperative treatment. JF - Clinics in Sports Medicine AU - Baker, M M AU - Juhn AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 315 EP - 329 VL - 19 IS - 2 SN - 0278-5919, 0278-5919 KW - Physical Education Index KW - Athletic injuries KW - Women KW - Knees KW - Medications KW - Legs KW - Pain KW - Biomechanics KW - Athletes KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18142561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+Sports+Medicine&rft.atitle=Patellofemoral+pain+syndrome+in+the+female+athlete.&rft.au=Baker%2C+M+M%3BJuhn&rft.aulast=Baker&rft.aufirst=M&rft.date=2000-04-01&rft.volume=19&rft.issue=2&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Clinics+in+Sports+Medicine&rft.issn=02785919&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Pain; Athletes; Athletic injuries; Medications; Knees; Legs; Women; Biomechanics ER - TY - JOUR T1 - Effect of rest from running on overuse injuries in army basic training. AN - 18140475; 4867194 AB - BACKGROUND: It has been hypothesized that a period of rest from running in the early weeks of basic military training will prevent stress fractures among recruits. DESIGN: Modification of running schedules in companies of Army recruits undergoing basic military training was assigned. SETTING/PARTICIPANTS: Six male training companies were enrolled and followed during their 8 weeks of basic military training at Fort Bliss, Texas, in summer/fall 1989. INTERVENTION: Intervention companies were asked to rest from running during the second, third, or fourth week of basic military training. MAIN OUTCOME MEASURES: Data were collected from questionnaires, anthropometric measurements, Army physical fitness tests, company training logs, and medical record abstraction of all clinic visits. RESULTS: Among the 1357 enrolled male recruits, there were 236 (17%) with overuse injury and 144 (11%) with traumatic injury, resulting in 535 clinic visits and 1927 training days lost. Stress fracture/reaction rates varied from 3 to 8 per 100 recruits among the intervention companies and 2 to 7 per 100 recruits among the non-intervention companies. Total injury rates were 18 to 35 per 100 recruits in the intervention companies and 18 to 29 per 100 recruits in the non-intervention companies. CONCLUSIONS: The study provided no evidence for a protective effect on overuse injuries of resting from running for 1 week early in basic military training. There was varied physical training among the companies, however, with variation of injury rates that likely related to factors other than the intervention. JF - American Journal of Preventive Medicine AU - Popovich, R M AU - Gardner, J W AU - Potter, R AU - Knapik, J J AU - Jones, B H AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 147 EP - 155 VL - 18 IS - 3 Suppl SN - 0749-3797, 0749-3797 KW - Physical Education Index KW - Overuse injuries KW - Rest KW - Fractures KW - Running (problems) KW - Military KW - Epidemiology (injuries) KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18140475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Effect+of+rest+from+running+on+overuse+injuries+in+army+basic+training.&rft.au=Popovich%2C+R+M%3BGardner%2C+J+W%3BPotter%2C+R%3BKnapik%2C+J+J%3BJones%2C+B+H&rft.aulast=Popovich&rft.aufirst=R&rft.date=2000-04-01&rft.volume=18&rft.issue=3+Suppl&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Military; Running (problems); Overuse injuries; Fractures; Rest; Epidemiology (injuries) ER - TY - JOUR T1 - Induction of premature chromosome condensation by a phosphatase inhibitor and a protein kinase in unstimulated human peripheral blood lymphocytes: a simple and rapid technique to study chromosome aberrations using specific whole-chromosome DNA hybridization probes for biological dosimetry. AN - 70980798; 10727901 AB - We developed a simple and rapid method to study chromosome aberrations involving specific chromosomes using unstimulated human peripheral blood lymphocytes (HPBL). Premature chromosome condensation (PCC) was induced by incubating unstimulated HPBL in the presence of okadaic acid (OA, a phosphatase inhibitor), adenosine triphosphate (ATP), and p34(cdc2)/cyclin B kinase [an essential component of mitosis-promoting factor (MPF)], which eliminated the need for fusion with mitotic cells. OA concentration and duration of incubation for PCC induction was optimized using mitogen-stimulated HPBL; a final concentration of 0.75 microM incubated for 3 h was optimum, resulting in approximately 20% PCC yield. In unstimulated HPBL, PCC was induced by the addition of p34(cdc2)/cyclin B kinase at concentrations as low as 5 units/ml to a cell culture medium containing OA. Increases in the concentration of p34(cdc2)/cyclin B kinase from 5 to 50 units/ml resulted in a concentration-dependent increase in PCC yield (30% to 42%). We demonstrate that this technique of inducing PCC in unstimulated HPBL is suitable for studying radiation-induced aberrations involving a specific chromosome (chromosome 1) after 24 h repair using a whole-chromosome in situ hybridization probe and chromosome painting. Cells with aberrant chromosome number 1 are characterized with more than two chromosome spots. The frequency of cells with aberrant chromosome 1 increased with 60Co gamma-radiation doses in the region 0-7.5 Gy. The observed dose-effect relationship for the percentage of cells with aberrant chromosome 1 (Y) was explained by using both a linear [Y=(2.77+/-0.230)D+0.90+/-0.431, r(2)=0.966] and a nonlinear power [Y=(5.70+/-0.46)D((0.61+/-0.05)), r(2)=0.9901) model. This technique can be applied to biological dosimetry of radiation exposures involving uniform whole-body low linear energy transfer (LET) exposures. JF - Mutation research AU - Prasanna, P G AU - Escalada, N D AU - Blakely, W F AD - Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA. prasanna@mx.afrri.usuhs.mil Y1 - 2000/03/23/ PY - 2000 DA - 2000 Mar 23 SP - 131 EP - 141 VL - 466 IS - 2 SN - 0027-5107, 0027-5107 KW - Mitogens KW - 0 KW - Okadaic Acid KW - 1W21G5Q4N2 KW - CDC2 Protein Kinase KW - EC 2.7.11.22 KW - CDC28 Protein Kinase, S cerevisiae KW - Cyclin-Dependent Kinases KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Index Medicus KW - Space life sciences KW - Mitogens -- pharmacology KW - Mutagenicity Tests -- methods KW - Dose-Response Relationship, Drug KW - Humans KW - CDC28 Protein Kinase, S cerevisiae -- pharmacology KW - Chromosome Aberrations KW - Dose-Response Relationship, Radiation KW - Radiometry -- methods KW - Time Factors KW - CDC2 Protein Kinase -- pharmacology KW - Chromosome Painting KW - Phosphoprotein Phosphatases -- antagonists & inhibitors KW - Cyclin-Dependent Kinases -- pharmacology KW - Chromosomes, Human -- radiation effects KW - Chromosomes, Human -- metabolism KW - Chromosomes, Human -- drug effects KW - Okadaic Acid -- pharmacology KW - Lymphocytes -- radiation effects KW - Lymphocytes -- metabolism KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70980798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Induction+of+premature+chromosome+condensation+by+a+phosphatase+inhibitor+and+a+protein+kinase+in+unstimulated+human+peripheral+blood+lymphocytes%3A+a+simple+and+rapid+technique+to+study+chromosome+aberrations+using+specific+whole-chromosome+DNA+hybridization+probes+for+biological+dosimetry.&rft.au=Prasanna%2C+P+G%3BEscalada%2C+N+D%3BBlakely%2C+W+F&rft.aulast=Prasanna&rft.aufirst=P&rft.date=2000-03-23&rft.volume=466&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-19 N1 - Date created - 2000-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protocol for alcohol outpatient detoxification. AN - 72501550; 11143631 JF - Lippincott's primary care practice AU - Martin, A C AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. PY - 2000 SP - 221 EP - 227 VL - 4 IS - 2 SN - 1088-5471, 1088-5471 KW - Anti-Anxiety Agents KW - 0 KW - Nursing KW - Outpatients KW - Humans KW - Alcoholism -- diagnosis KW - Specialties, Nursing -- methods KW - Anti-Anxiety Agents -- therapeutic use KW - Alcoholism -- nursing KW - Primary Health Care -- methods KW - Clinical Protocols KW - Alcoholism -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72501550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lippincott%27s+primary+care+practice&rft.atitle=Protocol+for+alcohol+outpatient+detoxification.&rft.au=Martin%2C+A+C&rft.aulast=Martin&rft.aufirst=A&rft.date=2000-03-01&rft.volume=4&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Lippincott%27s+primary+care+practice&rft.issn=10885471&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2000-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Co-occurrence of alcohol, smokeless tobacco, cigarette, and illicit drug use by lower ranking military personnel. AN - 71082324; 10795949 AB - The Worldwide Survey of Health Related Behaviors is administered periodically to a probability sample of military personnel. Earlier reports of these surveys suggested that illicit drug use was highest among the lowest ranking personnel. This paper reports a secondary analysis of the 1992 and 1995 surveys of the lowest ranking personnel. The results suggested that in general illicit drug users tended also to use alcohol, smokeless tobacco, and cigarettes. Heavy drinkers were more likely than light drinkers to use illicit drugs. No such relationship was observed between illicit drug use and the level of use of cigarettes or smokeless tobacco. Moreover, among the heavy drinkers, illicit drug users were especially likely to use cigarettes and among males, smokeless tobacco. The relevance of these results to military policies toward illicit drug use is discussed. JF - Addictive behaviors AU - Kao, T C AU - Schneider, S J AU - Hoffman, K J AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. tkao@usuhs.mil PY - 2000 SP - 253 EP - 262 VL - 25 IS - 2 SN - 0306-4603, 0306-4603 KW - Street Drugs KW - 0 KW - Index Medicus KW - Regression Analysis KW - Cross-Sectional Studies KW - Humans KW - Health Surveys KW - Adult KW - Incidence KW - Adolescent KW - Male KW - Female KW - Comorbidity KW - Tobacco Use Disorder -- epidemiology KW - Military Personnel -- statistics & numerical data KW - Smoking -- psychology KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Smoking -- epidemiology KW - Tobacco, Smokeless KW - Plants, Toxic KW - Alcoholism -- epidemiology KW - Military Personnel -- psychology KW - Tobacco Use Disorder -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71082324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Co-occurrence+of+alcohol%2C+smokeless+tobacco%2C+cigarette%2C+and+illicit+drug+use+by+lower+ranking+military+personnel.&rft.au=Kao%2C+T+C%3BSchneider%2C+S+J%3BHoffman%2C+K+J&rft.aulast=Kao&rft.aufirst=T&rft.date=2000-03-01&rft.volume=25&rft.issue=2&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-17 N1 - Date created - 2000-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Norwalk-like viral gastroenteritis outbreak in U.S. Army trainees. AN - 71035841; 10756159 AB - An outbreak of acute gastroenteritis hospitalized 99 (12%) of 835 U. S. Army trainees at Fort Bliss, El Paso, Texas, from August 27 to September 1, 1998. Reverse transcriptase polymerase chain reaction tests for Norwalk-like virus were positive for genogroup 2. Gastroenteritis was associated with one post dining facility and with soft drinks. JF - Emerging infectious diseases AU - Arness, M K AU - Feighner, B H AU - Canham, M L AU - Taylor, D N AU - Monroe, S S AU - Cieslak, T J AU - Hoedebecke, E L AU - Polyak, C S AU - Cuthie, J C AU - Fankhauser, R L AU - Humphrey, C D AU - Barker, T L AU - Jenkins, C D AU - Skillman, D R AD - Uniformed Services University of the Health Sciences, Bethesda, MD, marness@pol.net PY - 2000 SP - 204 EP - 207 VL - 6 IS - 2 SN - 1080-6040, 1080-6040 KW - Index Medicus KW - Odds Ratio KW - Food Microbiology KW - Texas -- epidemiology KW - Military Personnel KW - Humans KW - United States -- epidemiology KW - Caliciviridae Infections -- epidemiology KW - Norwalk virus KW - Disease Outbreaks KW - Gastroenteritis -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71035841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+infectious+diseases&rft.atitle=Norwalk-like+viral+gastroenteritis+outbreak+in+U.S.+Army+trainees.&rft.au=Arness%2C+M+K%3BFeighner%2C+B+H%3BCanham%2C+M+L%3BTaylor%2C+D+N%3BMonroe%2C+S+S%3BCieslak%2C+T+J%3BHoedebecke%2C+E+L%3BPolyak%2C+C+S%3BCuthie%2C+J+C%3BFankhauser%2C+R+L%3BHumphrey%2C+C+D%3BBarker%2C+T+L%3BJenkins%2C+C+D%3BSkillman%2C+D+R&rft.aulast=Arness&rft.aufirst=M&rft.date=2000-03-01&rft.volume=6&rft.issue=2&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Emerging+infectious+diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-25 N1 - Date created - 2000-05-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 1982 Jun;96(6 Pt 1):756-61 [6283977] Am J Public Health. 1982 Dec;72(12):1329-32 [6291414] Arch Intern Med. 1991 Dec;151(12):2419-24 [1660704] JAMA. 1993 Feb 3;269(5):627-30 [8380619] Clin Microbiol Rev. 1993 Jul;6(3):199-210 [8395330] J Virol. 1972 Nov;10(5):1075-81 [4117963] J Clin Microbiol. 1995 Jan;33(1):64-71 [7699068] Clin Infect Dis. 1995 Jun;20(6):1497-504 [7548499] J Clin Pathol. 1996 Nov;49(11):874-80 [8944604] J Clin Pathol. 1996 Dec;49(12):959-64 [9038729] J Infect Dis. 1969 Jun;119(6):668-73 [5795109] Am J Trop Med Hyg. 1995 Feb;52(2):188-93 [7872452] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gliotoxin-induced cytotoxicity proceeds via apoptosis and is mediated by caspases and reactive oxygen species in LLC-PK1 cells. AN - 71003999; 10746946 AB - Renal failure associated with aspergillosis is caused by pathogenic fungi. Gliotoxin is a toxic epipolythiodioxopiperazine metabolite produced by the pathogens. The present study investigated the cytotoxicity and underlying mechanisms induced by gliotoxin in LLC-PK1 cells, a porcine renal proximal tubular cell line. Gliotoxin at 100 ng/ml did not show a cytotoxic effect, but unmasked a dose-dependent cell death induced by TNF-alpha. TNF-alpha-induced cell death in the presence of gliotoxin was associated with hypodiploid nuclei and activation of caspase-3-like proteases. Blockade of caspases by boc-aspartyl (OMe)-fluoromethylketone and z-DEVD.fmk inhibited TNF-alpha-induced cell death. As the concentrations of gliotoxin were increased, gliotoxin killed the cells directly in a dose-dependent manner. Further analyses of DNA fragmentation, hypodiploid nuclei, mitochondrial membrane potential, and plasma membrane integrity revealed that cell death proceeded via apoptosis. Gliotoxin-induced apoptosis was associated with dose-dependent and time-dependent activation of caspase-3-like proteases. Boc-aspartyl (OMe)-fluoromethylketone attenuated the killing effect. Gliotoxin also increased the intracellular levels of reactive oxygen species as measured by flow cytometry. N-acetylcysteine, a well-known antioxidant, completely abolished the gliotoxin-induced caspase-3-like activity, cytotoxicity, and reactive oxygen species. In conclusion, (1) gliotoxin at 100 ng/ml unmasks the ability of TNF-alpha-induced apoptosis, and the effect of TNF-alpha is mediated by caspase-3-like proteases; and (2) at higher concentrations gliotoxin itself induces cell death, which is via apoptosis and dependent on caspase-3-like activity and reactive oxygen species. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Zhou, X AU - Zhao, A AU - Goping, G AU - Hirszel, P AD - Department of Medicine, Uniformed Services University, Bethesda, Maryland 20814, USA. xiazhou@usuhs.mil Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 194 EP - 202 VL - 54 IS - 1 SN - 1096-6080, 1096-6080 KW - Immunosuppressive Agents KW - 0 KW - Reactive Oxygen Species KW - Tumor Necrosis Factor-alpha KW - Propidium KW - 36015-30-2 KW - Gliotoxin KW - 67-99-2 KW - Caspases KW - EC 3.4.22.- KW - Gentian Violet KW - J4Z741D6O5 KW - Index Medicus KW - Swine KW - Animals KW - Kidney Tubules -- cytology KW - Kidney Tubules -- drug effects KW - Tumor Necrosis Factor-alpha -- pharmacology KW - LLC-PK1 Cells KW - DNA Fragmentation -- drug effects KW - Membrane Potentials -- drug effects KW - Reactive Oxygen Species -- metabolism KW - Immunosuppressive Agents -- toxicity KW - Apoptosis -- drug effects KW - Caspases -- biosynthesis KW - Gliotoxin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71003999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Gliotoxin-induced+cytotoxicity+proceeds+via+apoptosis+and+is+mediated+by+caspases+and+reactive+oxygen+species+in+LLC-PK1+cells.&rft.au=Zhou%2C+X%3BZhao%2C+A%3BGoping%2C+G%3BHirszel%2C+P&rft.aulast=Zhou&rft.aufirst=X&rft.date=2000-03-01&rft.volume=54&rft.issue=1&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-02 N1 - Date created - 2000-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synergy of activin and ciliary neurotrophic factor signaling pathways in the induction of vasoactive intestinal peptide gene expression. AN - 70953195; 10707960 AB - Activin, a member of the transforming growth factor-beta superfamily, can regulate neuropeptide gene expression in the nervous system and in neuroblastoma cells. Among the neuropeptide genes whose expression can be regulated by activin is the gene encoding the neuropeptide vasoactive intestinal peptide (VIP). To investigate the molecular mechanisms by which activin regulates neuronal gene expression, we have examined activin's regulation of VIP gene expression in NBFL neuroblastoma cells. We report here that NBFL cells respond to activin by increasing expression of VIP mRNA. Activin regulates VIP gene transcription in NBFL cells through a 180-bp element in the VIP promoter that was previously characterized to be necessary and sufficient to mediate the induction of VIP by the neuropoietic cytokines and termed the cytokine response element (CyRE). We find that the VIP CyRE is necessary and sufficient to mediate the transcriptional response to activin. In addition, ciliary neurotrophic factor (CNTF), a neuropoietic cytokine, synergizes with activin to increase VIP mRNA expression and transcription through the VIP CyRE. Mutations in either the Stat (signal transducer and activator of transcription) or AP-1 sites within the CyRE that reduce the response to CNTF, also reduce the response to activin. However, mutating both the Stat and AP-1 sites within the wild-type CyRE, while reducing the separate responses to either activin or CNTF, eliminates the synergy between them. These data suggest that activin and CNTF, two factors that appear to signal though distinct pathways, activate VIP gene transcription through a common transcriptional element, the VIP CyRE. JF - Molecular endocrinology (Baltimore, Md.) AU - Symes, A J AU - Pitts, R L AU - Conover, J AU - Kos, K AU - Coulombe, J AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. asymes@usuhs.mil Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 429 EP - 439 VL - 14 IS - 3 SN - 0888-8809, 0888-8809 KW - Ciliary Neurotrophic Factor KW - 0 KW - DNA-Binding Proteins KW - Neoplasm Proteins KW - Recombinant Fusion Proteins KW - STAT1 Transcription Factor KW - STAT1 protein, human KW - Trans-Activators KW - Transcription Factor AP-1 KW - Transforming Growth Factor beta KW - Activins KW - 104625-48-1 KW - Vasoactive Intestinal Peptide KW - 37221-79-7 KW - Inhibins KW - 57285-09-3 KW - Index Medicus KW - Neuroblastoma -- pathology KW - Transforming Growth Factor beta -- pharmacology KW - Trans-Activators -- metabolism KW - Recombinant Fusion Proteins -- biosynthesis KW - Animals KW - Neoplasm Proteins -- biosynthesis KW - Tumor Cells, Cultured -- drug effects KW - Transcription Factor AP-1 -- metabolism KW - Humans KW - Neuroblastoma -- metabolism KW - Promoter Regions, Genetic KW - Chickens KW - Transfection KW - Neoplasm Proteins -- genetics KW - Binding Sites -- genetics KW - Drug Synergism KW - Mutation KW - DNA-Binding Proteins -- metabolism KW - Vasoactive Intestinal Peptide -- biosynthesis KW - Regulatory Sequences, Nucleic Acid KW - Signal Transduction -- drug effects KW - Ciliary Neurotrophic Factor -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Vasoactive Intestinal Peptide -- genetics KW - Inhibins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70953195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Synergy+of+activin+and+ciliary+neurotrophic+factor+signaling+pathways+in+the+induction+of+vasoactive+intestinal+peptide+gene+expression.&rft.au=Symes%2C+A+J%3BPitts%2C+R+L%3BConover%2C+J%3BKos%2C+K%3BCoulombe%2C+J&rft.aulast=Symes&rft.aufirst=A&rft.date=2000-03-01&rft.volume=14&rft.issue=3&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-21 N1 - Date created - 2000-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Counterproliferation, Conventional Counterforce and Nuclear War AN - 60572348; 200103873 AB - This essay examines an increasingly important element of US defense policy, counterproliferation. It explains how US security strategy is no longer constrained by Mutual Assured Destruction: American strategists now contemplate using precision conventional weapons to deny proliferants nuclear capabilities. The study also suggests that US nuclear deterrent capabilities backstop counterproliferation policies. It explores the risks inherent in counterproliferation & how US escalation dominance helps to reduce these risks. In conclusion, the analysis questions whether new counterproliferation strategies are superior to arms control or deterrence in countering nuclear-armed states. Adapted from the source document. JF - The Journal of Strategic Studies AU - Wirtz, James J AD - US Naval Postgraduate School, Monterey, CA Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 5 EP - 24 VL - 23 IS - 1 SN - 0140-2390, 0140-2390 KW - Disarmament KW - Armaments KW - United States of America KW - Deterrence KW - Foreign Policy KW - Nuclear Weapons KW - article KW - 9063: international relations; international relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60572348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Strategic+Studies&rft.atitle=Counterproliferation%2C+Conventional+Counterforce+and+Nuclear+War&rft.au=Wirtz%2C+James+J&rft.aulast=Wirtz&rft.aufirst=James&rft.date=2000-03-01&rft.volume=23&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Strategic+Studies&rft.issn=01402390&rft_id=info:doi/ LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSTSD5 N1 - SubjectsTermNotLitGenreText - Nuclear Weapons; Armaments; Disarmament; United States of America; Foreign Policy; Deterrence ER - TY - JOUR T1 - The last rat-free petrel colony? AN - 17704108; 5683357 AB - Ta'u Island, American Samoa (14 degree S, 169 degree W), is often referred to as the cradle of Polynesian exploration. Yet even in the island's earliest human history, the summit of Mt. Lata, the highest point on Ta'u, remained remote and mysterious. Today little has changed, with the exception of the pristine summit area now coming under the protection of the US National Park Service as part of a 50-year lease signed with local village chiefs. American Samoa is the only US territory in the southern hemisphere, and contains the only example of insular paleotropical cloud forest under US jurisdiction. Sizeable petrel populations are being discovered here as part of the National Park's current efforts to assess seabird populations and breeding areas in the territory. In support of similar claims by previous summit research trips, our preliminary observations suggest an absence of feral mammals, namely rats, cats and pigs, from the upper elevations of Mt. Lata. If further trapping reveals this is indeed true, the summit of Mt. Lata represents crucially unique breeding habitat for at least one, if not several, petrel and shearwater species believed to be nesting there (Pterodroma rostrata, P. heraldica, P. brevipes, Puffinus lherminieri, P. pacificus). We are interested in knowing where similar predator-free breeding areas remain world-wide, if any, and what procellariid species are present in those areas. JF - Marine Ornithology AU - O'Connor, P J AD - Research Corporation of the University of Hawai'i, 3190 Maile Way, St. John #410, Honolulu, HI 96799, USA, paul_o'connor@nps.gov A2 - Flint, Eand Swift K (eds) Y1 - 2000/03// PY - 2000 DA - March 2000 PB - African Seabird Group VL - 28 IS - 2 SN - 1018-3337, 1018-3337 KW - Gadfly petrels KW - Predator-free environment KW - ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - ISE, Pacific, American Samoa, Ta'u I. KW - Marine KW - Marine birds KW - Policies KW - Puffinus lherminieri KW - Pest control KW - Predators KW - Habitat selection KW - USA KW - Colonies KW - Breeding sites KW - Nesting KW - Nature conservation KW - Home range KW - Governments KW - Environment management KW - Pterodroma KW - Q5 08523:Conservation, wildlife management and recreation KW - O 1080:Multi-disciplinary Studies KW - Q1 08485:Species interactions: pests and control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17704108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Marine+Ornithology&rft.atitle=The+last+rat-free+petrel+colony%3F&rft.au=O%27Connor%2C+P+J&rft.aulast=O%27Connor&rft.aufirst=P&rft.date=2000-03-01&rft.volume=28&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Marine+Ornithology&rft.issn=10183337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Abstracts of oral and poster presentations. N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Policies; Colonies; Marine birds; Breeding sites; Nesting; Nature conservation; Governments; Predators; Pest control; Home range; Habitat selection; Environment management; Puffinus lherminieri; Pterodroma; ISE, Pacific, American Samoa, Ta'u I.; USA; Marine ER - TY - JOUR T1 - Current status of the endangered Hawaiian Dark-rumped Petrel Pterodroma phaeopygia sandwichensis at Haleakalae and Hawaii Volcanoes National Parks AN - 17699591; 5683327 AB - The Hawaiian Dark-rumped Petrel Pterodroma phaeopygia sandwichensis is Hawaii's only endangered seabird species. Once found throughout the Hawaiian Islands, the species is now confined to high elevations. Habitat loss and predation by introduced predators caused the decline of this species. Currently, known nesting populations are located only on Haleakalae, Maui and Mauna Loa, Hawaii. Observations have been made of Hawaiian Dark-rumped Petrels flying to mountains on Kauai. However, nests have not been found. We present the status of the Haleakalae and Mauna Loa populations, population trends, current threats, and management activities. JF - Marine Ornithology AU - Hodges, C N AU - Hu, D AD - Haleakalae National Park, PO Box 369, Makawao, HI 96768, USA, cathleen_hodges@nps.gov A2 - Flint, Eand Swift K (eds) Y1 - 2000/03// PY - 2000 DA - March 2000 PB - African Seabird Group VL - 28 IS - 2 SN - 1018-3337, 1018-3337 KW - Hawaiian dark-rumped petrel KW - Population decline KW - ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - Marine birds KW - Ecological distribution KW - Predators KW - Rare species KW - USA, Hawaii, Hawaii I., Mauna Loa Volcano KW - USA, Hawaii, Kauai I. KW - Habitat selection KW - USA, Hawaii, Maui I. KW - Distribution records KW - Breeding sites KW - Census KW - Pterodroma phaeopygia sandwichensis KW - Biotic factors KW - Sanctuaries KW - Q5 08523:Conservation, wildlife management and recreation KW - Q1 08361:General KW - O 1080:Multi-disciplinary Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17699591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Marine+Ornithology&rft.atitle=Current+status+of+the+endangered+Hawaiian+Dark-rumped+Petrel+Pterodroma+phaeopygia+sandwichensis+at+Haleakalae+and+Hawaii+Volcanoes+National+Parks&rft.au=Hodges%2C+C+N%3BHu%2C+D&rft.aulast=Hodges&rft.aufirst=C&rft.date=2000-03-01&rft.volume=28&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Marine+Ornithology&rft.issn=10183337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Abstracts of oral and poster presentations. N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Marine birds; Breeding sites; Distribution records; Ecological distribution; Predators; Census; Rare species; Habitat selection; Biotic factors; Sanctuaries; Pterodroma phaeopygia sandwichensis; USA, Hawaii, Maui I.; USA, Hawaii, Kauai I.; USA, Hawaii, Hawaii I., Mauna Loa Volcano ER - TY - JOUR T1 - Multicomponent Intervention for Work-Related Upper Extremity Disorders AN - 17668259; 4749489 AB - Although several multidimensional models have emerged to explain the development, exacerbation and maintenance of work-related upper extremity disorders and disability, there is a paucity of data on the application of these models for the development of worksite-based prevention and management programs. Sign language interpreting is an occupation associated with increased risk for upper extremity symptoms. Ergonomic, work organization, work style, and work-related and individual psychosocial factors have been demonstrated to play a role in the exacerbation of symptoms and lost time in this group. Therefore, it was hypothesized that an intervention directed at reducing the impact of these factors would be associated with reductions in the number of upper extremity cases/year and associated lost time and health care costs in a group of full-time sign language interpreters. Subjects included 53 symptomatic and asymptomatic interpreters working at the National Technical Institute for the Deaf. The intervention (eleven 1.5-hr group sessions) was designed to 1) reduce musculoskeletal overexertion by reducing workload and biomechanical strain, while increasing flexibility and endurance through tailored exercise and preinterpreting "warm ups," 2) improve the ability of workers to manage job stress and musculoskeletal pain, 3) reduce biomechanical exposure through work organization and work style changes, 4) alter organizational sources of stress by improving supervisor's managerial skills to address work related upper extremity problems and provide increased supervisor support, and 5) educate workers and supervisors regarding the optimal utilization of health care resources, given the present state of the art in terms of clinical evaluation and management. Results indicated a 69% reduction in the number of cases reporting upper extremity problems in the 3 years following the intervention. Indemnity costs were reduced by 64% and were maintained over the next 2 years. Health care costs followed a similar, although smaller magnitude, change. Despite this reduction, a partial rebound in all outcome measures was observed in Year 3 postintervention. This rebound followed a progressive increase in workload over the 3-year follow-up period. JF - Journal of Occupational Rehabilitation AU - Feuerstein, M AU - Marshall, L AU - Shaw, W S AU - Burrell, L M AD - Uniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, 4301 Jones Bridge Road, Bethesda, MD 20814, USA, mfeuerstein@usuhs.mil Y1 - 2000/03// PY - 2000 DA - Mar 2000 SP - 71 EP - 83 VL - 10 IS - 1 SN - 1053-0487, 1053-0487 KW - biomechanics KW - musculoskeletal system KW - pain KW - upper extremities KW - Health & Safety Science Abstracts KW - Economics KW - Stress KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17668259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+Rehabilitation&rft.atitle=Multicomponent+Intervention+for+Work-Related+Upper+Extremity+Disorders&rft.au=Feuerstein%2C+M%3BMarshall%2C+L%3BShaw%2C+W+S%3BBurrell%2C+L+M&rft.aulast=Feuerstein&rft.aufirst=M&rft.date=2000-03-01&rft.volume=10&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Rehabilitation&rft.issn=10530487&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Economics; Occupational health; Stress ER - TY - JOUR T1 - In vivo bypass of hemophilia A coagulation defect by Factor XIIa implant AN - 17511626; 4697026 AB - Hemophilia A and B coagulation defects, which are caused by deficiencies of Factor VIII and Factor IX, respectively, can be bypassed by administration of recombinant Factor VIIa. However, the short half-life of recombinant Factor VIIa in vivo negates its routine clinical use. We report here an in vivo method for the continuous generation of Factor VIIa. The method depends on the implantation of a porous chamber that contains Factor Xa or XIIa, and continuously generates Factor VIIa bypass activity from the subject's own Factor VII, which enters the chamber by diffusion. Once inside, the Factor VII is cleaved to Factor VIIa by the immobilized Factor Xa or XIIa. The newly created Factor VIIa diffuses out of the chamber and back into the circulation, where it can bypass the deficient Factors VIII or IX, and enable coagulation to occur. In vitro, this method generates sufficient Factor VIIa to substantially correct Factor VIII-deficient plasma when assessed by the classical aPTT coagulation assay. In vivo, a Factor XIIa peritoneal implant generates bypass activity for up to one month when tested in rhesus monkeys. Implantation of such a chamber in a patient with hemophilia A or B could eventually provide a viable alternative to replacement therapies using exogenous coagulation factors. JF - Nature Biotechnology AU - Ton-That, T T AU - Doron, D AU - Pollard, B S AU - Bacher, J AU - Pollard, H B AD - Department of Anatomy and Cell Biology, Uniformed Services University School of Medicine, USUHS, Bethesda, MD 10814, USA, hpollard@usuhs.mil Y1 - 2000/03// PY - 2000 DA - Mar 2000 SP - 289 EP - 295 VL - 18 IS - 3 SN - 1087-0156, 1087-0156 KW - monkeys KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Factor VIII deficiency KW - Implants KW - Coagulation factors KW - Immobilization KW - Hemophilia KW - W3 33190:Therapy: Other KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17511626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=In+vivo+bypass+of+hemophilia+A+coagulation+defect+by+Factor+XIIa+implant&rft.au=Ton-That%2C+T+T%3BDoron%2C+D%3BPollard%2C+B+S%3BBacher%2C+J%3BPollard%2C+H+B&rft.aulast=Ton-That&rft.aufirst=T&rft.date=2000-03-01&rft.volume=18&rft.issue=3&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2F73727 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Coagulation factors; Immobilization; Implants; Hemophilia; Factor VIII deficiency DO - http://dx.doi.org/10.1038/73727 ER - TY - JOUR T1 - Influence of synthetic antiendotoxin peptides on lipopolysaccharide (LPS) recognition and LPS-induced proinflammatory cytokine responses by cells expressing membrane-bound CD14 AN - 17492971; 4687952 AB - Lipopolysaccharides (LPS) are proinflammatory bacterial products implicated in the pathogenesis of gram-negative sepsis and septic shock. Polymyxin B (PMB), a cyclic, cationic peptide antibiotic, inhibits biological activities of LPS through high-affinity binding to the lipid A moiety. Small synthetic peptides have been designed to mimic the primary and secondary structures of PMB to determine structural requirements for binding and detoxification of lipid A and to assess possible therapeutic potential. The purpose of this study was to compare and contrast the endotoxin-neutralizing activities of two synthetic antiendotoxin peptides (SAEP-2 and SAEP-4), PMB, and an LPS core-specific monoclonal antibody (MAb), WN1 222-5, based on their abilities to inhibit CD14-mediated target cell uptake of fluorescein isothiocyanate (FITC)-conjugated LPS, detected by flow cytometry and confocal microscopy, and LPS-induced production of the proinflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF- alpha ), as measured by bioassays. PMB and SAEP-4 produced dose-dependent inhibition of FITC-LPS uptake by CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells) and by human peripheral blood mononuclear cells. The anti-LPS MAb, WN1 222-5, also blocked LPS uptake by these cells and synergized with PMB and SAEP-4. LPS-induced IL-6 release was inhibited by PMB, SAEP-4, and MAb WN1 222-5, and these inhibitory activities were additive or synergistic. LPS-induced TNF- alpha release by PBMC was also inhibited by PMB and SAEP-4 alone and in combination with anti-LPS MAb. SAEP-2, in contrast, produced comparatively minor decrements in cellular uptake of LPS and LPS-induced cytokine responses, and did so only in the absence of serum, while a nonsense peptide exerted no discernible inhibitory effect on LPS uptake or LPS-induced cytokine expression in the presence or absence of serum. Thus, PMB and SAEP-4, like the LPS-reactive MAb, WN1 222-5, block proinflammatory activities of LPS in part by preventing LPS recognition by membrane-bound CD14-expressing target cells. Differences in peptide structure, however, like those exemplified by SAEP-2 and SAEP-4, may differentially affect the endotoxin-neutralizing potency of these peptides despite similar binding activity against lipid A, reflecting possible differences in peptide solubility or peptide regulation of intracellular signal transduction. JF - Infection and Immunity AU - Iwagaki, A AU - Porro, M AU - Pollack, M AD - Department of Medicine, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA, mpollack@usuhs.mil Y1 - 2000/03// PY - 2000 DA - Mar 2000 SP - 1655 EP - 1663 VL - 68 IS - 3 SN - 0019-9567, 0019-9567 KW - man KW - immunology KW - bacteria KW - CD14 antigen KW - Lipopolysaccharides KW - SAEP-2 protein KW - SAEP-4 protein KW - endotoxins KW - lipid A KW - lipopolysaccharides KW - Immunology Abstracts; Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Interleukin 6 KW - Endotoxins KW - Monoclonal antibodies KW - Tumor necrosis factor KW - Fibroblasts KW - Inflammation KW - Cell membranes KW - Gram-negative bacteria KW - peptide antibiotics KW - Cytokines KW - Lipid A KW - X 24171:Microbial KW - F 06735:Mediators KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17492971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Influence+of+synthetic+antiendotoxin+peptides+on+lipopolysaccharide+%28LPS%29+recognition+and+LPS-induced+proinflammatory+cytokine+responses+by+cells+expressing+membrane-bound+CD14&rft.au=Iwagaki%2C+A%3BPorro%2C+M%3BPollack%2C+M&rft.aulast=Iwagaki&rft.aufirst=A&rft.date=2000-03-01&rft.volume=68&rft.issue=3&rft.spage=1655&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.68.3.1655-1663.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Endotoxins; Lipid A; peptide antibiotics; Monoclonal antibodies; Interleukin 6; Tumor necrosis factor; Cell membranes; Gram-negative bacteria; Lipopolysaccharides; Inflammation; Cytokines; Fibroblasts DO - http://dx.doi.org/10.1128/IAI.68.3.1655-1663.2000 ER - TY - JOUR T1 - Elastase in Intestinal Mucus Enhances the Cytotoxicity of Shiga Toxin Type 2d AN - 17452548; 4666686 AB - Shiga toxin variant type 2d (Stx2d) produced by some strains of Shiga toxin-producing Escherichia coli is composed of an enzymatically active A subunit and a B (binding) pentamer. The cytotoxicity of Stx2d is increased (activated) 10-1000-fold for Vero cells when the toxin is incubated with mucus obtained from the small intestine of mice. In this study we isolated an Stx2d activator and identified it as a mouse elastase with strong homology to human elastase IIIB. Moreover, commercially available porcine pancreatic elastase preparations also activated Stx2d cytotoxicity although with a lower specific activity than isolated mouse elastase. Elastase directly nicked the Stx2d A subunit to A sub(1) and A sub(2), an event that did not correlate with activation. However, elastase also reduced the size and changed the isoelectric point of the A sub(2) peptide, as determined by SDS-polyacrylamide gel electrophoresis and two-dimensional electrophoresis followed by Western immunoblot analysis. This elastase-mediated size and charge shift in the A sub(2) peptide of Stx2d occurred concurrently with activation of the toxin. Both the reduction in size of the Stx2d A sub(2) peptide by incubation with elastase as well as the associated activation of Stx2d cytotoxicity were fully inhibited by elastatinal, an elastase-specific inhibitor. JF - Journal of Biological Chemistry AU - Kokai-Kun, J F AU - Melton-Celsa, A R AU - O'Brien, AD AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, aobrien@usuhs.mil Y1 - 2000/02/04/ PY - 2000 DA - 2000 Feb 04 SP - 3713 EP - 3721 VL - 275 IS - 5 SN - 0021-9258, 0021-9258 KW - mice KW - Shiga toxin KW - elastase KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Escherichia coli KW - Mucus KW - Small intestine KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17452548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Elastase+in+Intestinal+Mucus+Enhances+the+Cytotoxicity+of+Shiga+Toxin+Type+2d&rft.au=Kokai-Kun%2C+J+F%3BMelton-Celsa%2C+A+R%3BO%27Brien%2C+AD&rft.aulast=Kokai-Kun&rft.aufirst=J&rft.date=2000-02-04&rft.volume=275&rft.issue=5&rft.spage=3713&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.275.5.3713 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Small intestine; Mucus DO - http://dx.doi.org/10.1074/jbc.275.5.3713 ER - TY - JOUR T1 - WR-151327 increases resistance to Klebsiella pneumoniae infection in mixed-field- and gamma-photon-irradiated mice. AN - 70968074; 10716647 AB - To determine the efficacy of WR-151327 (WR) [S-3-(3-methylaminopropylamino) propylphosphorothioic acid; (CH3-HN-(CH2)3-NH-(CH2)3-S-PO3H2)] in increasing resistance to bacterial infection after a sublethal dose of gamma-photons or mixed-field neutrons plus gamma-photons. B6D2F1/J female mice received 200 mg/kg WR i.p. or saline vehicle 20-30 min before or after sham (0 Gy) or 7.0 Gy 60Co gamma-photon irradiation. WR or saline vehicle was given only before 3.5 Gy TRIGA-reactor-produced mixed-field [n/(n+y) = 0.67] irradiation. Four days after drug treatment or drug treatment and irradiation, graded doses of Klebsiella pneumoniae were injected s.c. into mice, and 30-day survival was recorded. To assess haemopoietic changes other unirradiated and irradiated mice not injected with bacteria were given WR or saline. Peripheral blood (PB) and femoral bone marrow (BM) cells were measured 1, 3 or 4, 7, 10 and 14 or 15 days later. WR pretreatment increased resistance to infection in irradiated but not in unirradiated mice. Bacterial CFU-LD50/30 values for 0 Gy saline-treated mice were 1.20x10(6); for 0 Gy WR-treated mice 1.16x10(6); for gamma-photon-irradiated saline-treated mice 3.02x10(1); for gamma-photon-irradiated WR-treated mice 1.24x10(4); for mixed-field-irradiated saline-treated mice 1.94x10(2); and for mixed-field-irradiated WR-treated mice 6.13x10(3). WR-induced resistance to infection paralleled increased numbers of PB white cells, neutrophils, platelets, femoral BM cells and granulocyte macrophage colony-forming cells (GM-CFC) in irradiated mice not given bacteria. These studies quantify the resistance to bacterial infection in mice treated with WR before sublethal irradiation. The findings suggest that WR treatment increases resistance to infection in immunocompromised hosts. JF - International journal of radiation biology AU - Ledney, G D AU - Elliott, T B AU - Harding, R A AU - Jackson, W E AU - Inal, C E AU - Landauer, M R AD - Radiation Medicine Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5603, USA. ledney@mx.afrri.usuhs.mil Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 261 EP - 271 VL - 76 IS - 2 SN - 0955-3002, 0955-3002 KW - Organothiophosphorus Compounds KW - 0 KW - Radiation-Protective Agents KW - WR 151327 KW - 82147-31-7 KW - Index Medicus KW - Space life sciences KW - Bone Marrow Cells -- drug effects KW - Animals KW - Relative Biological Effectiveness KW - Gamma Rays KW - Bone Marrow Cells -- radiation effects KW - Mice KW - Female KW - Blood Cell Count KW - Klebsiella Infections -- mortality KW - Immunity, Innate -- radiation effects KW - Immunity, Innate -- drug effects KW - Klebsiella Infections -- immunology KW - Radiation-Protective Agents -- pharmacology KW - Organothiophosphorus Compounds -- pharmacology KW - Klebsiella pneumoniae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70968074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+biology&rft.atitle=WR-151327+increases+resistance+to+Klebsiella+pneumoniae+infection+in+mixed-field-+and+gamma-photon-irradiated+mice.&rft.au=Ledney%2C+G+D%3BElliott%2C+T+B%3BHarding%2C+R+A%3BJackson%2C+W+E%3BInal%2C+C+E%3BLandauer%2C+M+R&rft.aulast=Ledney&rft.aufirst=G&rft.date=2000-02-01&rft.volume=76&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+biology&rft.issn=09553002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-23 N1 - Date created - 2000-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enzymatic properties of dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis and its participation in virulence. AN - 70871532; 10639438 AB - Porphyromonas gingivalis is a major pathogen associated with adult periodontitis. We cloned and sequenced the gene (dpp) coding for dipeptidyl aminopeptidase IV (DPPIV) from P. gingivalis W83, based on the amino acid sequences of peptide fragments derived from purified DPPIV. An Escherichia coli strain overproducing P. gingivalis DPPIV was constructed. The enzymatic properties of recombinant DPPIV purified from the overproducer were similar to those of DPPIV isolated from P. gingivalis. The three amino acid residues Ser, Asp, and His, which are thought to form a catalytic triad in the C-terminal catalytic domain of eukaryotic DPPIV, are conserved in P. gingivalis DPPIV. When each of the corresponding residues of the enzyme was substituted with Ala by site-directed mutagenesis, DPPIV activity significantly decreased, suggesting that these three residues of P. gingivalis DPPIV are involved in the catalytic reaction. DPPIV-deficient mutants of P. gingivalis were constructed and subjected to animal experiments. Mice injected with the wild-type strain developed abscesses to a greater extent and died more frequently than those challenged with mutant strains. Mice injected with the mutants exhibited faster recovery from the infection, as assessed by weight gain and the rate of lesion healing. This decreased virulence of mutants compared with the parent strain suggests that DPPIV is a potential virulence factor of P. gingivalis and may play important roles in the pathogenesis of adult periodontitis induced by the organism. JF - Infection and immunity AU - Kumagai, Y AU - Konishi, K AU - Gomi, T AU - Yagishita, H AU - Yajima, A AU - Yoshikawa, M AD - Department of Microbiology, Nippon Dental University, Fujimi 1-9-20, Chiyoda-ku, Tokyo 102-8159, Japan. yumi-mic@tokyo.ndu.ac.jp Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 716 EP - 724 VL - 68 IS - 2 SN - 0019-9567, 0019-9567 KW - Recombinant Proteins KW - 0 KW - Dipeptidyl Peptidase 4 KW - EC 3.4.14.5 KW - Index Medicus KW - Virulence KW - Animals KW - Recombinant Proteins -- metabolism KW - Humans KW - Mice KW - Amino Acid Sequence KW - Mice, Inbred BALB C KW - Catalysis KW - Dipeptidyl Peptidase 4 -- metabolism KW - Dipeptidyl Peptidase 4 -- isolation & purification KW - Porphyromonas gingivalis -- pathogenicity KW - Porphyromonas gingivalis -- enzymology KW - Dipeptidyl Peptidase 4 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70871532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Enzymatic+properties+of+dipeptidyl+aminopeptidase+IV+produced+by+the+periodontal+pathogen+Porphyromonas+gingivalis+and+its+participation+in+virulence.&rft.au=Kumagai%2C+Y%3BKonishi%2C+K%3BGomi%2C+T%3BYagishita%2C+H%3BYajima%2C+A%3BYoshikawa%2C+M&rft.aulast=Kumagai&rft.aufirst=Y&rft.date=2000-02-01&rft.volume=68&rft.issue=2&rft.spage=716&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-10 N1 - Date created - 2000-02-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Microbiol Rev. 1993 Mar;57(1):50-108 [8096622] Biochim Biophys Acta. 1992 Jul 15;1131(3):333-6 [1352704] Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6594-8 [7912830] Yeast. 1994 Jun;10(6):801-10 [7975897] Infect Immun. 1995 Apr;63(4):1521-8 [7890419] J Immunol. 1995 May 15;154(10):5331-7 [7730636] Arch Biochem Biophys. 1995 Jun 20;320(1):123-8 [7793970] J Biol Chem. 1995 Oct 6;270(40):23619-26 [7559528] Microbiology. 1995 Dec;141 ( Pt 12):3067-75 [8574400] Trends Microbiol. 1995 Nov;3(11):430-4 [8574516] J Immunol Methods. 1996 Jan 16;189(1):99-105 [8576585] J Bacteriol. 1996 May;178(10):2818-24 [8631669] Biochim Biophys Acta. 1997 Jul 18;1340(2):215-26 [9252108] J Biol Chem. 1997 Nov 28;272(48):30283-8 [9374514] Infect Immun. 1998 Mar;66(3):1159-66 [9488409] Biochim Biophys Acta. 1998 Mar 4;1396(1):39-46 [9524216] J Immunol. 1997 Dec 15;159(12):6070-6 [9550406] Immunol Rev. 1998 Feb;161:43-53 [9553763] Immunol Rev. 1998 Feb;161:55-70 [9553764] J Biochem. 1998 Aug;124(2):428-33 [9685737] FEBS Lett. 1998 Jul 17;431(2):236-40 [9708910] J Biol Chem. 1998 Sep 11;273(37):24207-15 [9727044] Biochemistry. 1998 Sep 8;37(36):12672-80 [9730840] Trends Microbiol. 1998 Nov;6(11):444-9 [9846362] J Biol Chem. 1999 Apr 2;274(14):9246-52 [10092598] Curr Med Chem. 1999 Apr;6(4):311-27 [10101215] J Cell Biol. 1989 Apr;108(4):1363-73 [2647766] Biochem J. 1989 Aug 15;262(1):327-34 [2573346] Oral Microbiol Immunol. 1989 Dec;4(4):222-6 [2640317] Gene. 1990 May 31;90(1):141-4 [2199326] Appl Environ Microbiol. 1991 Jan;57(1):38-44 [1674655] Appl Environ Microbiol. 1991 Jan;57(1):45-50 [1674656] J Biol Chem. 1992 Feb 5;267(4):2200-8 [1370813] J Biol Chem. 1992 Mar 5;267(7):4824-33 [1347043] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Gene. 1982 Oct;19(3):259-68 [6295879] Proc Natl Acad Sci U S A. 1985 Jan;82(2):488-92 [3881765] J Dent Res. 1985 Feb;64(2):106-11 [3882793] Nucleic Acids Res. 1986 Jun 11;14(11):4683-90 [3714490] Science. 1988 Jan 1;239(4835):55-7 [3336774] J Bacteriol. 1988 Jun;170(6):2575-83 [2836362] Nature. 1988 Aug 11;334(6182):528-30 [3136396] J Immunol. 1992 Jul 15;149(2):481-6 [1352530] J Biol Chem. 1993 Aug 15;268(23):17247-52 [8102366] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Blending HF radar and model velocities in Monterey Bay through normal mode analysis AN - 50154337; 2002-046439 AB - Nowcasts of the surface velocity field in Monterey Bay are made for the period August 1-9, 1994, using HF radar observations blended with results from a primitive equation model. A spectral method called normal mode analysis was used. Objective spatial and temporal filtering were performed, and stream function, velocity potential, relative vorticity, and horizontal divergence were calculated over the domain. This type of nowcasting permits global spectral analysis of mode amplitudes, calculation of enstrophy, and additional analyses using tools like empirical orthogonal functions. The nowcasts reported here include open boundary flow information from the numerical model. Nowcasts using no open boundary flow information, however, still provide excellent results for locations within the observation footprint. This method, then, is useful for filtering high-resolution data like HF radar observations, even when open boundary flow information is unavailable. Also, since the nowcast velocity gradient fields were much less noisy than the observations, this may be an effective method for preconditioning high-resolution observation sets for assimilation into a numerical model. Copyright 2000 by the American Geophysical Union. JF - Journal of Geophysical Research AU - Lipphardt, B L, Jr AU - Kirwan, A D, Jr AU - Grosch, C E AU - Lewis, J K AU - Paduan, J D Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 3425 EP - 3450 PB - American Geophysical Union, Washington, DC VL - 105 IS - C2 SN - 0148-0227, 0148-0227 KW - United States KW - East Pacific KW - currents KW - high-resolution methods KW - ocean circulation KW - numerical models KW - Northeast Pacific KW - radar methods KW - ocean currents KW - California KW - open boundary flow KW - North Pacific KW - Monterey Bay KW - Pacific Ocean KW - Ocean Surface Current Radar KW - velocity KW - arrays KW - Dirichlet modes KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50154337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Blending+HF+radar+and+model+velocities+in+Monterey+Bay+through+normal+mode+analysis&rft.au=Lipphardt%2C+B+L%2C+Jr%3BKirwan%2C+A+D%2C+Jr%3BGrosch%2C+C+E%3BLewis%2C+J+K%3BPaduan%2C+J+D&rft.aulast=Lipphardt&rft.aufirst=B&rft.date=2000-02-01&rft.volume=105&rft.issue=C2&rft.spage=3425&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F1999JC900295 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 15 N1 - PubXState - DC N1 - Document feature - illus. incl. 4 tables, geol. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - arrays; California; currents; Dirichlet modes; East Pacific; high-resolution methods; Monterey Bay; North Pacific; Northeast Pacific; numerical models; ocean circulation; ocean currents; Ocean Surface Current Radar; open boundary flow; Pacific Ocean; radar methods; United States; velocity DO - http://dx.doi.org/10.1029/1999JC900295 ER - TY - JOUR T1 - Multiple Electrofishing Removals for Eliminating Rainbow Trout in a Small Southern Appalachian Stream AN - 17818799; 4856794 AB - We evaluated multiple electrofishing removals of rainbow trout Oncorhynchus mykiss as a management tool for the restoration of native brook trout Salvelinus fontinalis in a small southern Appalachian stream. Six, three-pass depletion removal efforts were conducted between June 1996 and October 1997. Four removals successfully eliminated rainbow trout reproduction. Five removals were required to successfully eliminate rainbow trout from Mannis Branch. During the study, 428 rainbow trout were removed from the treatment area. The initial removal collected 296 (70%) of the total rainbow trout removed and was dominated by adults. Subsequent removals were dominated by age-0 rainbow trout (57-83%). The initial two removals successfully eliminated 96% of the reproductively mature adults as well as 86% of the age-0 fish. In October 1996, 105 native southern Appalachian brook trout of various age-classes were reintroduced into Mannis Branch. Surveys conducted in May 1997 indicated adult brook trout successfully spawned, initiating repopulation of the treatment area. Multiple removals exhibited no negative population level effects on blacknose dace Rhynichthys atratulus in the treatment area or on rainbow trout in the control stream. Based upon these results, a minimum of three removals conducted per summer should eliminate reproduction and significantly reduce the number of years required to successfully restore a small southern Appalachian stream. JF - North American Journal of Fisheries Management AU - Kulp, MA AU - Moore, SE AD - Great Smoky Mountains National Park, 107 Park Headquarters Road, Gatlinburg, Tennessee 37738, USA, matt_kulp@nps.gov Y1 - 2000/02// PY - 2000 DA - Feb 2000 SP - 259 EP - 266 VL - 20 IS - 1 SN - 0275-5947, 0275-5947 KW - Brook trout KW - Rainbow trout KW - native species KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Electric fishing KW - Salvelinus fontinalis KW - USA, Appalachian Mts. KW - Rhynichthys atratulus KW - Ecosystem management KW - Oncorhynchus mykiss KW - Pest control KW - Freshwater KW - Introduced species KW - Freshwater fish KW - Restoration KW - Q5 08523:Conservation, wildlife management and recreation KW - Q1 08341:General KW - Q1 08485:Species interactions: pests and control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17818799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=North+American+Journal+of+Fisheries+Management&rft.atitle=Multiple+Electrofishing+Removals+for+Eliminating+Rainbow+Trout+in+a+Small+Southern+Appalachian+Stream&rft.au=Kulp%2C+MA%3BMoore%2C+SE&rft.aulast=Kulp&rft.aufirst=MA&rft.date=2000-02-01&rft.volume=20&rft.issue=1&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=North+American+Journal+of+Fisheries+Management&rft.issn=02755947&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Electric fishing; Ecosystem management; Pest control; Freshwater fish; Introduced species; Restoration; Salvelinus fontinalis; Rhynichthys atratulus; Oncorhynchus mykiss; USA, Appalachian Mts.; Freshwater ER - TY - JOUR T1 - Neuropharmacology and linguistic neuroplasticity. AN - 85338758; pmid-10716818 JF - Brain and language AU - Hughes, J D AU - Jacobs, D H AU - Heilman, K M AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. jhughes@usuhs.mil Y1 - 2000/01// PY - 2000 DA - Jan 2000 SP - 96 EP - 101 VL - 71 IS - 1 SN - 0093-934X, 0093-934X KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Neurotransmitter Agents -- therapeutic use KW - Aphasia -- drug therapy KW - Neuronal Plasticity -- physiology KW - Linguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85338758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+language&rft.atitle=Neuropharmacology+and+linguistic+neuroplasticity.&rft.au=Hughes%2C+J+D%3BJacobs%2C+D+H%3BHeilman%2C+K+M&rft.aulast=Hughes&rft.aufirst=J&rft.date=2000-01-01&rft.volume=71&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Brain+and+language&rft.issn=0093934X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Engineering Deinococcus radiodurans for metal remediation in radioactive mixed waste environments AN - 762278897; 13744198 AB - We have developed a radiation resistant bacterium for the treatment of mixed radioactive wastes containing ionic mercury. The high cost of remediating radioactive waste sites from nuclear weapons production has stimulated the development of bioremediation strategies using Deinococcus radiodurans, the most radiation resistant organism known. As a frequent constituent of these sites is the highly toxic ionic mercury (Hg) (II), we have generated several D. radiodurans strains expressing the cloned Hg (II) resistance gene (merA) from Escherichia coli strain BL308. We designed four different expression vectors for this purpose, and compared the relative advantages of each. The strains were shown to grow in the presence of both radiation and ionic mercury at concentrations well above those found in radioactive waste sites, and to effectively reduce Hg (II) to the less toxic volatile elemental mercury. We also demonstrated that different gene clusters could be used to engineer D. radiodurans for treatment of mixed radioactive wastes by developing a strain to detoxify both mercury and toluene. These expression systems could provide models to guide future D. radiodurans engineering efforts aimed at integrating several remediation functions into a single host. JF - Nature Biotechnology AU - Brim, Hassan AU - McFarlan, Sara C AU - Fredrickson, James K AU - Minton, Kenneth W AU - Zhai, Min AU - Wackett, Lawrence P AU - Daly, Michael J AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 2000/01// PY - 2000 DA - Jan 2000 SP - 85 EP - 90 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 18 IS - 1 SN - 1087-0156, 1087-0156 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Water Resources Abstracts; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Aqualine Abstracts; Biotechnology and Bioengineering Abstracts KW - Bioremediation KW - Radioactive Wastes KW - Mercury KW - Deinococcus radiodurans KW - X:24390 KW - A:01320 KW - J:02310 KW - SW 3050:Ultimate disposal of wastes KW - W 30950:Waste Treatment & Pollution Clean-up KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762278897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Engineering+Deinococcus+radiodurans+for+metal+remediation+in+radioactive+mixed+waste+environments&rft.au=Brim%2C+Hassan%3BMcFarlan%2C+Sara+C%3BFredrickson%2C+James+K%3BMinton%2C+Kenneth+W%3BZhai%2C+Min%3BWackett%2C+Lawrence+P%3BDaly%2C+Michael+J&rft.aulast=Brim&rft.aufirst=Hassan&rft.date=2000-01-01&rft.volume=18&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2F71986 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Mercury; Radioactive Wastes; Deinococcus radiodurans DO - http://dx.doi.org/10.1038/71986 ER - TY - JOUR T1 - Lps: another piece in the puzzle. AN - 72610137; 11521048 JF - Journal of endotoxin research AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 295 EP - 300; discussion 301-2 VL - 6 IS - 4 SN - 0968-0519, 0968-0519 KW - Drosophila Proteins KW - 0 KW - Lipopolysaccharides KW - Membrane Glycoproteins KW - Ran protein, mouse KW - Receptors, Cell Surface KW - Toll-Like Receptors KW - Monomeric GTP-Binding Proteins KW - EC 3.6.5.2 KW - ran GTP-Binding Protein KW - Index Medicus KW - Animals KW - Mice, Inbred C3H KW - Lipopolysaccharides -- toxicity KW - Mice KW - Mice, Inbred BALB C KW - Signal Transduction KW - Cloning, Molecular KW - Receptors, Cell Surface -- genetics KW - Monomeric GTP-Binding Proteins -- genetics KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72610137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+endotoxin+research&rft.atitle=Lps%3A+another+piece+in+the+puzzle.&rft.au=Vogel%2C+S+N&rft.aulast=Vogel&rft.aufirst=S&rft.date=2000-01-01&rft.volume=6&rft.issue=4&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Journal+of+endotoxin+research&rft.issn=09680519&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-11 N1 - Date created - 2001-08-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Endotoxin Res. 2000;6(4):269-93 [11521047] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of human cell lines from multiple organs. AN - 72418604; 11083093 AB - While the majority of carcinogenesis studies have relied on the use of rodent cells in culture, experimental models to define the role of carcinogenic agents in the development of cancers must be established by using a variety of human cells. Unlike rodent cells, normal human cells in culture rarely undergo spontaneous transformation and have generally proven to be resistant to neoplastic transformation by carcinogens. Remarkable progress has been made during the past decade in human cell transformation systems. Malignant transformation of human cells in culture has been achieved by a stepwise process: immortalization and conversion of the immortalized cells to tumorigenic cells. One of the critical initial events in the progression of normal human cells to tumor cells is the escape from cellular senescence, with few exceptions; normal human cells require immortalization to provide a practical system for carcinogenesis studies. Different cell types require different conditions and transforming agents to achieve a useful cell line. The current state of the art in immortalization of human cells will be presented. JF - Annals of the New York Academy of Sciences AU - Rhim, J S AD - Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 16 EP - 25 VL - 919 SN - 0077-8923, 0077-8923 KW - Carcinogens KW - 0 KW - Oncogene Proteins, Viral KW - Index Medicus KW - Animals KW - Clone Cells -- pathology KW - Simian virus 40 -- genetics KW - Humans KW - Adenoviruses, Human -- genetics KW - Carcinogens -- toxicity KW - Papillomaviridae -- genetics KW - Organ Specificity KW - Carcinogens -- analysis KW - Simian virus 40 -- physiology KW - Oncogene Proteins, Viral -- metabolism KW - Cell Aging -- drug effects KW - Tumor Cells, Cultured KW - Papillomaviridae -- metabolism KW - Adenoviruses, Human -- physiology KW - Oncogene Proteins, Viral -- genetics KW - Cell Line, Transformed KW - Cell Transformation, Viral KW - Cell Culture Techniques -- methods KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72418604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Development+of+human+cell+lines+from+multiple+organs.&rft.au=Rhim%2C+J+S&rft.aulast=Rhim&rft.aufirst=J&rft.date=2000-01-01&rft.volume=919&rft.issue=&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-06 N1 - Date created - 2000-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selection of yeast mutants in sphingolipid metabolism. AN - 72403344; 11070881 JF - Methods in enzymology AU - Dunn, T M AU - Gable, K AU - Monaghan, E AU - Bacikova, D AD - Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 317 EP - 330 VL - 312 SN - 0076-6879, 0076-6879 KW - Ceramides KW - 0 KW - Sphingolipids KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calcium -- metabolism KW - Genes, Suppressor KW - Mutagenesis KW - Cloning, Molecular KW - Saccharomyces cerevisiae -- genetics KW - Saccharomyces cerevisiae -- metabolism KW - Genes, Fungal KW - Suppression, Genetic KW - Sphingolipids -- biosynthesis KW - Ceramides -- biosynthesis KW - Sphingolipids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72403344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+enzymology&rft.atitle=Selection+of+yeast+mutants+in+sphingolipid+metabolism.&rft.au=Dunn%2C+T+M%3BGable%2C+K%3BMonaghan%2C+E%3BBacikova%2C+D&rft.aulast=Dunn&rft.aufirst=T&rft.date=2000-01-01&rft.volume=312&rft.issue=&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Methods+in+enzymology&rft.issn=00766879&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NPS 1506, a moderate affinity uncompetitive NMDA receptor antagonist: preclinical summary and clinical experience. AN - 72314661; 11026487 AB - NPS Pharmaceuticals, Inc. (NPS) has synthesized a series of open-channel blockers with varying potencies at the NMDA receptor. NPS 1506 (Fig. 1) is a moderate affinity antagonist that inhibits NMDA/glycine-induced increases in cytosolic calcium in cultured rat cerebellar granule cells (IC50 = 476nM) and displaces the binding of [3H]MK-801 to rat cortical membranes (IC50 = 664nM). JF - Amino acids AU - Mueller, A L AU - Artman, L D AU - Balandrin, M F AU - Brady, E AU - Chien, Y AU - DelMar, E G AU - Kierstead, A AU - Marriott, T B AU - Moe, S T AU - Raszkiewicz, J L AU - VanWagenen, B AU - Wells, D AD - NPS Pharmaceuticals, Inc., Salt Lake City, Utah 84108, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 177 EP - 179 VL - 19 IS - 1 SN - 0939-4451, 0939-4451 KW - Excitatory Amino Acid Antagonists KW - 0 KW - Fluorobenzenes KW - NPS 1506 KW - Placebos KW - Receptors, N-Methyl-D-Aspartate KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Index Medicus KW - Rats KW - Cerebral Cortex -- cytology KW - Animals KW - Dizocilpine Maleate -- metabolism KW - Cerebral Cortex -- drug effects KW - Double-Blind Method KW - Cerebral Cortex -- metabolism KW - Cells, Cultured KW - Humans KW - Adult KW - Adolescent KW - Male KW - Female KW - Fluorobenzenes -- adverse effects KW - Fluorobenzenes -- pharmacology KW - Excitatory Amino Acid Antagonists -- therapeutic use KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Fluorobenzenes -- therapeutic use KW - Excitatory Amino Acid Antagonists -- adverse effects KW - Fluorobenzenes -- pharmacokinetics KW - Excitatory Amino Acid Antagonists -- pharmacokinetics KW - Excitatory Amino Acid Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72314661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Amino+acids&rft.atitle=NPS+1506%2C+a+moderate+affinity+uncompetitive+NMDA+receptor+antagonist%3A+preclinical+summary+and+clinical+experience.&rft.au=Mueller%2C+A+L%3BArtman%2C+L+D%3BBalandrin%2C+M+F%3BBrady%2C+E%3BChien%2C+Y%3BDelMar%2C+E+G%3BKierstead%2C+A%3BMarriott%2C+T+B%3BMoe%2C+S+T%3BRaszkiewicz%2C+J+L%3BVanWagenen%2C+B%3BWells%2C+D&rft.aulast=Mueller&rft.aufirst=A&rft.date=2000-01-01&rft.volume=19&rft.issue=1&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Amino+acids&rft.issn=09394451&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2001-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Low in vivo levels of human anx7 (annexin vii) gene expression are due to endogenous inhibitory promoter sequences. AN - 71230535; 10875895 AB - ANX7 is a Ca(2+)/GTP-dependent membrane fusion protein, which is involved in regulating exocytotic secretion. While the nullizygous ANX7 (-/-) knockout mutation in the mouse is lethal, ANX7 is nonetheless the least expressed member of the annexin gene family in mammalian and lower organisms. To investigate the basis for low ANX7 expression level we have studied the human ANX7 promoter. In our early cloning studies we learned that the human ANX7 promoter lacks TATA and CCAAT boxes, but is GC rich and contains several SP1 binding sites. To study how expression of the ANX7 gene is controlled, we fused nested deletion mutants of the 5'-flanking region to a luciferase reporter gene. We find that the maximal level of luciferase activity is obtained by a construct comprising the domain -889/+34. However, a repressor effect observed in the region between -240 and +34 is dramatically eliminated either by the inclusion of 177 bp upstream sequences, or by the presence of an upstream SV40 enhancer sequences. ANX7 gene expression is also cell type specific and is subject to different transcriptional controls in different cellular environments. The fact that the SV40 enhancer sequences not only eliminates the suppression of luciferase activity in the inhibitory region of the ANX7 promoter, but also reverses the inhibitory effect of phorbol ester, suggests that endogenous cis-acting elements or transacting factors may be responsible for the physiologically low level of ANX7 protein expression. Copyright 2000 Academic Press. JF - Cell biology international AU - Srivastava, M AU - Pollard, H B AD - Department of Anatomy and Cell Biology and Institute for Molecular Medicine, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. msrivastava@usuhs.mil Y1 - 2000 PY - 2000 DA - 2000 SP - 475 EP - 481 VL - 24 IS - 7 SN - 1065-6995, 1065-6995 KW - Annexin A7 KW - 0 KW - Dexamethasone KW - 7S5I7G3JQL KW - Luciferases KW - EC 1.13.12.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Simian virus 40 -- genetics KW - Dexamethasone -- pharmacology KW - Humans KW - Mice KW - Rats KW - Base Sequence KW - Genes KW - Transfection KW - Enhancer Elements, Genetic KW - Genes, Reporter KW - Molecular Sequence Data KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Line KW - Cricetinae KW - Promoter Regions, Genetic KW - Gene Expression Regulation KW - Annexin A7 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71230535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+biology+international&rft.atitle=Low+in+vivo+levels+of+human+anx7+%28annexin+vii%29+gene+expression+are+due+to+endogenous+inhibitory+promoter+sequences.&rft.au=Srivastava%2C+M%3BPollard%2C+H+B&rft.aulast=Srivastava&rft.aufirst=M&rft.date=2000-01-01&rft.volume=24&rft.issue=7&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Cell+biology+international&rft.issn=10656995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-22 N1 - Date created - 2000-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is the (relatively) low use of analgesics in elderly AD patients a problem? AN - 71185068; 10855755 JF - Psychiatry AU - Ader, D N AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 16 EP - 17 VL - 63 IS - 1 SN - 0033-2747, 0033-2747 KW - Analgesics KW - 0 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Index Medicus KW - Humans KW - Pain Measurement KW - Aged KW - Drug Utilization KW - Pain -- drug therapy KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Alzheimer Disease -- drug therapy KW - Anti-Inflammatory Agents, Non-Steroidal -- administration & dosage KW - Analgesics -- administration & dosage KW - Analgesics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71185068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=Is+the+%28relatively%29+low+use+of+analgesics+in+elderly+AD+patients+a+problem%3F&rft.au=Ader%2C+D+N&rft.aulast=Ader&rft.aufirst=D&rft.date=2000-01-01&rft.volume=63&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-19 N1 - Date created - 2000-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Psychiatry. 2000 Spring;63(1):1-12 [10855753] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Airborne aldehydes from heating rosin core solder and liquid rosin flux to soldering temperatures. AN - 71032287; 10772621 AB - Gas phase aldehydes produced from heating rosin core solder and liquid rosin flux to temperatures commonly used in soldering were trapped on sampling tubes containing XAD-2 resin coated with the derivatizing agent 2-hydroxymethylpiperidine. Analysis of the resulting oxazolidine derivatives was performed using gas chromatography/mass spectrometry (GC/MS). The observed aldehyde derivatives included formaldehyde, acetaldehyde, propionaldehyde, acrolein, isobutyraldehyde, butyraldehyde, isovaleraldehyde, valeraldehyde, furfural, hexanal, cyclohexane carboxaldehyde and other unidentified compounds likely to be aldehyde isomers. Formaldehyde, acetaldehyde, and benzaldehyde were detected in blank samples. By comparison with an internal standard, a sample produced by drawing air with contaminants derived by heating rosin core solder through a sampling tube contained levels of formaldehyde and acetaldehyde much greater than seen in sampling tube blanks. Benzaldehyde was not shown to be present at a significantly greater level in samples from heating rosin core solder than in blanks prepared using the same analysis protocol. The use of National Institute of Occupational Safety and Health (NIOSH) method 2539 extraction procedures produced blanks with levels of formaldehyde significantly lower than with a modified extraction method (methylene chloride, no sonication). The modified extraction method produced significantly lower benzaldehyde levels in blanks compared with the NIOSH extraction method using toluene and sonication of sampling sorbent tubes. JF - AIHAJ : a journal for the science of occupational and environmental health and safety AU - Smith, P A AU - Bowerbank, C R AU - Lee, M L AU - Solberg, M AU - Drown, D B AU - Alexander, W AU - Still, K R AD - Uniformed Services University of the Health Sciences, Department of Preventive Medicine and Biometrics, Bethesda, MD, USA. PY - 2000 SP - 95 EP - 101 VL - 61 IS - 1 SN - 1529-8663, 1529-8663 KW - Air Pollutants, Occupational KW - 0 KW - Aldehydes KW - Resins, Plant KW - rosin KW - 88S87KL877 KW - Index Medicus KW - Hot Temperature KW - Humans KW - Gas Chromatography-Mass Spectrometry KW - Aldehydes -- analysis KW - Air Pollutants, Occupational -- analysis KW - Resins, Plant -- chemistry KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71032287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.atitle=Airborne+aldehydes+from+heating+rosin+core+solder+and+liquid+rosin+flux+to+soldering+temperatures.&rft.au=Smith%2C+P+A%3BBowerbank%2C+C+R%3BLee%2C+M+L%3BSolberg%2C+M%3BDrown%2C+D+B%3BAlexander%2C+W%3BStill%2C+K+R&rft.aulast=Smith&rft.aufirst=P&rft.date=2000-01-01&rft.volume=61&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=AIHAJ+%3A+a+journal+for+the+science+of+occupational+and+environmental+health+and+safety&rft.issn=15298663&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-04 N1 - Date created - 2000-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diagnostic evaluation of erectile dysfunction. AN - 70879022; 10643952 AB - Erectile dysfunction, the persistent inability to attain or maintain penile erection sufficient for sexual intercourse, affects millions of men to various degrees. The majority of cases have an organic etiology, most commonly vascular disease that decreases blood flow into the penis. Regardless of the primary cause, erectile dysfunction can have a negative impact on self-esteem, quality of life and interpersonal relationships. The initial step in evaluation is a detailed medical and social history, including a review of medication use. Discussion with the patient's sexual partner may clarify exacerbating issues. The physical examination focuses on the cardiovascular, neurologic and urogenital systems. Laboratory tests are useful to screen for common etiologic factors and, when indicated, to identify hypogonadal syndromes. Appropriate evaluation of erectile dysfunction leads to accurate advice, management and referral of patients with erectile dysfunction. JF - American family physician AU - Miller, T A AD - Department of Family Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 2000/01/01/ PY - 2000 DA - 2000 Jan 01 SP - 95 EP - 104, 109-10 VL - 61 IS - 1 SN - 0002-838X, 0002-838X KW - Abridged Index Medicus KW - Index Medicus KW - Patient Education as Topic KW - Diagnosis, Differential KW - Humans KW - Algorithms KW - Teaching Materials KW - Penile Erection KW - Male KW - Erectile Dysfunction -- chemically induced KW - Erectile Dysfunction -- psychology KW - Erectile Dysfunction -- physiopathology KW - Erectile Dysfunction -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70879022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=Diagnostic+evaluation+of+erectile+dysfunction.&rft.au=Miller%2C+T+A&rft.aulast=Miller&rft.aufirst=T&rft.date=2000-01-01&rft.volume=61&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-27 N1 - Date created - 2000-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - AMPA prevents glutamate-induced neurotoxicity and apoptosis in cultured cerebellar granule cell neurons. AN - 70540765; 15545006 AB - Exposure of cultured cerebellar neurons to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in the presence of aniracetam protects all of the vulnerable neurons against the excitotoxic actions of glutamate acting on N-methyl-D-aspartate receptors. The protective effect of AMPA was both time- and concentration-dependent. Aniracetam alone did not protect the neurons against the excitotoxic effects of glutamate. Pretreatment of cerebellar neurons with the AMPA antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione blocked the neuroprotective effect mediated by AMPA indicating that the neuroprotective effect is mediated specifically by AMPA receptors. An excitotoxic concentration of glutamate, which killed between 60-80% of granule cell neurons on day 8 in vitro, mediated its toxic effect via a time-dependent apoptotic pathway. Pretreatment of cerebellar granule cell neurons with AMPA (500 microM) completely blocked glutamate-mediated apoptosis. Our results suggest that AMPA receptors may play an important role in neuronal survival. JF - Neurotoxicity research AU - Banaudha, K AU - Marini, A M AD - Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 51 EP - 61 VL - 2 IS - 1 SN - 1029-8428, 1029-8428 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70540765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+research&rft.atitle=AMPA+prevents+glutamate-induced+neurotoxicity+and+apoptosis+in+cultured+cerebellar+granule+cell+neurons.&rft.au=Banaudha%2C+K%3BMarini%2C+A+M&rft.aulast=Banaudha&rft.aufirst=K&rft.date=2000-01-01&rft.volume=2&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+research&rft.issn=10298428&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-04 N1 - Date created - 2004-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The NATO Capabilities Gap and the European Union AN - 60532216; 200106688 AB - The defense-capabilities gap that divides the US from its European allies is real, & it matters. The gap can most usefully be viewed as the aggregate of multiple gaps relating to the organization & conduct of large-scale expeditionary operations. Transatlantic disparities in the ability to mount such operations became painfully obvious during NATO's Kosovo intervention in March-June 1999, & spurred commitments on both sides of the Atlantic to narrow the gap. However, a close examination of the European Union's post-Kosovo efforts to develop an autonomous military capability reveals serious obstacles to improving European forces. Chief among them is a deep reluctance to increase defense spending, in view of the low level of threat perceptions in NATO Europe & high social priorities in Europe. Adapted from the source document. JF - Survival AU - Yost, David S AD - Naval Postgraduate School, Monterey, CA Y1 - 2000/01// PY - 2000 DA - January 2000 SP - 97 EP - 128 VL - 42 IS - 4 SN - 0039-6338, 0039-6338 KW - European Union KW - Defense Spending KW - United States of America KW - International Alliances KW - National Security KW - Armed Forces KW - article KW - 9063: international relations; international relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60532216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Survival&rft.atitle=The+NATO+Capabilities+Gap+and+the+European+Union&rft.au=Yost%2C+David+S&rft.aulast=Yost&rft.aufirst=David&rft.date=2000-01-01&rft.volume=42&rft.issue=4&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Survival&rft.issn=00396338&rft_id=info:doi/ LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Armed Forces; National Security; International Alliances; United States of America; Defense Spending; European Union ER - TY - JOUR T1 - Seasonal fluctuations of temperature, salinity nitrate, chlorophyll and primary production at station H3/M1 over 1989-1996 in Monterey Bay, California AN - 52217626; 2001-049186 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Pennington, J Timothy AU - Chavez, Francisco P Y1 - 2000 PY - 2000 DA - 2000 SP - 947 EP - 973 PB - Pergamon, Oxford VL - 47 IS - 5-6 SN - 0967-0645, 0967-0645 KW - United States KW - upwelling KW - Northeast Pacific KW - salinity KW - environmental analysis KW - temperature KW - California KW - Monterey Bay KW - nitrate ion KW - productivity KW - wind energy KW - East Pacific KW - currents KW - California Current KW - time series analysis KW - pigments KW - statistical analysis KW - ocean currents KW - chlorophyll KW - organic compounds KW - North Pacific KW - Pacific Ocean KW - Coriolis force KW - seasonal variations KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52217626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Seasonal+fluctuations+of+temperature%2C+salinity+nitrate%2C+chlorophyll+and+primary+production+at+station+H3%2FM1+over+1989-1996+in+Monterey+Bay%2C+California&rft.au=Pennington%2C+J+Timothy%3BChavez%2C+Francisco+P&rft.aulast=Pennington&rft.aufirst=J&rft.date=2000-01-01&rft.volume=47&rft.issue=5-6&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 87 N1 - Document feature - illus. incl. 2 tables, geol. sketch maps N1 - Last updated - 2013-05-16 N1 - SubjectsTermNotLitGenreText - California; California Current; chlorophyll; Coriolis force; currents; East Pacific; environmental analysis; Monterey Bay; nitrate ion; North Pacific; Northeast Pacific; ocean currents; organic compounds; Pacific Ocean; pigments; productivity; salinity; seasonal variations; statistical analysis; temperature; time series analysis; United States; upwelling; wind energy ER - TY - JOUR T1 - Studies of the California Current System; Part 2 AN - 52216061; 2001-049185 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography Y1 - 2000 PY - 2000 DA - 2000 SP - 761 EP - 1176 PB - Pergamon, Oxford VL - 47 IS - 5-6 SN - 0967-0645, 0967-0645 KW - East Pacific KW - currents KW - sea water KW - California Current KW - Northeast Pacific KW - North Pacific KW - Pacific Ocean KW - salinity KW - ocean currents KW - productivity KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52216061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=761&rft.isbn=&rft.btitle=Studies+of+the+California+Current+System%3B+Part+2&rft.title=Studies+of+the+California+Current+System%3B+Part+2&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - SuppNotes - Individual papers within scope are cited separately N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - California Current; currents; East Pacific; North Pacific; Northeast Pacific; ocean currents; Pacific Ocean; productivity; salinity; sea water ER - TY - JOUR T1 - Long-term observations in acoustics; the Ocean Acoustic Observatory Federation AN - 50867225; 2008-039857 JF - Oceanography (Washington D.C.) AU - Orcutt, John AU - deGroot-Hedlin, Catherine AU - Hodgkiss, William AU - Kuperman, William AU - Munk, Walter AU - Vernon, Frank AU - Worcester, Peter AU - Bernard, Eddie AU - Dziak, Robert AU - Fox, Chris AU - Chiu, Ching-Sang AU - Collins, Curt AU - Mercer, James AU - Odom, Robert AU - Park, Minkyu AU - Soukup, Darin AU - Spindel, Robert AU - Ramberg, Steven E A2 - Wilson, W. Stanley Y1 - 2000 PY - 2000 DA - 2000 SP - 57 EP - 63 PB - Oceanography Society, Washington, DC VL - 13 IS - 2 SN - 1042-8275, 1042-8275 KW - tomography KW - T-waves KW - programs KW - monitoring KW - geophysical methods KW - case studies KW - acoustical methods KW - seismicity KW - observatories KW - marine methods KW - Pacific Ocean KW - volcanoes KW - propagation KW - earthquakes KW - arrays KW - acoustical waves KW - 19:Seismology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50867225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oceanography+%28Washington+D.C.%29&rft.atitle=Long-term+observations+in+acoustics%3B+the+Ocean+Acoustic+Observatory+Federation&rft.au=Orcutt%2C+John%3BdeGroot-Hedlin%2C+Catherine%3BHodgkiss%2C+William%3BKuperman%2C+William%3BMunk%2C+Walter%3BVernon%2C+Frank%3BWorcester%2C+Peter%3BBernard%2C+Eddie%3BDziak%2C+Robert%3BFox%2C+Chris%3BChiu%2C+Ching-Sang%3BCollins%2C+Curt%3BMercer%2C+James%3BOdom%2C+Robert%3BPark%2C+Minkyu%3BSoukup%2C+Darin%3BSpindel%2C+Robert%3BRamberg%2C+Steven+E&rft.aulast=Orcutt&rft.aufirst=John&rft.date=2000-01-01&rft.volume=13&rft.issue=2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Oceanography+%28Washington+D.C.%29&rft.issn=10428275&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 6 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acoustical methods; acoustical waves; arrays; case studies; earthquakes; geophysical methods; marine methods; monitoring; observatories; Pacific Ocean; programs; propagation; seismicity; T-waves; tomography; volcanoes ER - TY - JOUR T1 - Spatial and temporal characteristics of the mesoscale circulation of the California Current from eddy-resolving moored and shipboard measurements AN - 50153629; 2002-060909 AB - Moored observations of currents and temperatures made in the upper 600 m on eddy-resolving scales over a 2-year period are used to examine the spatial and temporal characteristics of the California Current mesoscale circulation. The observations were made at three principal longitudes: 124 degrees W, 126 degrees W, and 128 degrees W in the vicinity of Point Arena. They bracket the 600-km-wide band of high mesoscale variability found along the eastern boundary of the North Pacific. At all locations, the mesoscale variability was larger than the mean flow, and the spatial modes of variability as determined from empirical orthogonal function analysis consisted of an alongshore mode, a cross-shore mode, and a rotational mode. Observations made near the continental slope (124 degrees W) were dominated by the poleward flowing California Undercurrent, with mesoscale eddies and meanders superposed. The nearshore eddy kinetic energy peaked in a band centered around 60 days. Observations made at 128 degrees W, near the offshore boundary between the energetic mesoscale band and the "eddy desert" of the northeast Pacific, were characterized by small means, fewer eddy events, and a peak in eddy kinetic energy at 120-180 days. The good horizontal resolution of the current meter arrays allowed us to estimate the relative vorticity, horizontal divergence, and Rossby number and therefore to evaluate the relative strength and occurrence of anticyclones and cyclones. We found the mesoscale eddy field to be strongly nonlinear, with Rossby numbers ranging from 0.1 to 0.5. All of the eddies observed at the offshore site were nonlinear, deep, warm anticyclones. Shipboard hydrography revealed the origin of one of these anticyclones to be the California Undercurrent, and this eddy retained its strong anomalies after several months and several hundred kilometers of propagation. Despite the lower incidence of eddies as one moves west from the coast, the eddies that we observed offshore provide evidence for propagation and transport of properties from the coast to the central North Pacific across the California Current System. Copyright 2000 by the American Geophysical Union. JF - Journal of Geophysical Research AU - Chereskin, T K AU - Morris, M Y AU - Niiler, P P AU - Kosro, P M AU - Smith, R L AU - Ramp, S R AU - Collins, C A AU - Musgrave, D L Y1 - 2000/01// PY - 2000 DA - January 2000 SP - 1245 EP - 1269 PB - American Geophysical Union, Washington, DC VL - 105 IS - C1 SN - 0148-0227, 0148-0227 KW - United States KW - East Pacific KW - currents KW - ocean circulation KW - California Current KW - anticyclones KW - Northeast Pacific KW - ocean currents KW - Point Arena KW - measurement KW - California KW - spatial distribution KW - North Pacific KW - time factor KW - eddies KW - Pacific Ocean KW - ocean waves KW - Rossby numbers KW - kinetics KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50153629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Spatial+and+temporal+characteristics+of+the+mesoscale+circulation+of+the+California+Current+from+eddy-resolving+moored+and+shipboard+measurements&rft.au=Chereskin%2C+T+K%3BMorris%2C+M+Y%3BNiiler%2C+P+P%3BKosro%2C+P+M%3BSmith%2C+R+L%3BRamp%2C+S+R%3BCollins%2C+C+A%3BMusgrave%2C+D+L&rft.aulast=Chereskin&rft.aufirst=T&rft.date=2000-01-01&rft.volume=105&rft.issue=C1&rft.spage=1245&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F1999JC900252 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 32 N1 - PubXState - DC N1 - Document feature - illus. incl. 7 plates, 2 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - anticyclones; California; California Current; currents; East Pacific; eddies; kinetics; measurement; North Pacific; Northeast Pacific; ocean circulation; ocean currents; ocean waves; Pacific Ocean; Point Arena; Rossby numbers; spatial distribution; time factor; United States DO - http://dx.doi.org/10.1029/1999JC900252 ER - TY - JOUR T1 - Mechanisms of anterior cruciate ligament injury AN - 18161101; 5134022 AB - This study examined the mechanisms of anterior cruciate ligament (ACL) injury. In the first part of the study, using a comprehensive, standardized questionnaire, 89 athletes (100 knees) were interviewed about the events surrounding their ACL injury. A noncontact mechanism was reported in 71 (72%) knees and a contact injury in 28 (28%) knees; one patient was unsure if there was any contact. Most of the injuries were sustained at footstrike with the knee close to full extension. Noncontact mechanisms were classified as sudden deceleration prior to a change of direction or landing motion, while contact injuries occurred as a result of valgus collapse of the knee. Hamstring flexibility parameters revealed a statistically higher level of laxity in the injured athletes compared with a matched group of 28 controls. In the second part of the study, videotapes of 27 separate ACL disruptions were reviewed and confirmed that most noncontact injuries occur with the knee close to extension during a sharp deceleration or landing maneuver. Because the knee is in a position to allow the extensor mechanism to strain the ACL and maximum, eccentric muscle force conditions usually apply, the quadriceps may play an important role in ACL disruption. Passive protection of the ACL by the hamstring muscles may be reduced in patients with above-average flexibility. JF - Orthopedics AU - Boden, B P AU - Dean, G S AU - Feagin, JA AU - Garrett, W E AD - Uniformed Services University of the Health Sciences, Rockville, MD 20850, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 573 EP - 578 VL - 23 IS - 6 SN - 0147-7447, 0147-7447 KW - Physical Education Index KW - Videotape KW - Ligaments KW - Flexibility KW - Athletic injuries KW - Joint stability KW - Knees KW - Surveys KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18161101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Orthopedics&rft.atitle=Mechanisms+of+anterior+cruciate+ligament+injury&rft.au=Boden%2C+B+P%3BDean%2C+G+S%3BFeagin%2C+JA%3BGarrett%2C+W+E&rft.aulast=Boden&rft.aufirst=B&rft.date=2000-01-01&rft.volume=23&rft.issue=6&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Orthopedics&rft.issn=01477447&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ligaments; Athletic injuries; Knees; Surveys; Flexibility; Joint stability; Videotape ER - TY - JOUR T1 - Anthrax: Clinical Features, Pathogenesis, and Potential Biological Warfare Threat AN - 17812139; 4850722 AB - Anthrax is a zoonotic disease that infects domesticated and wild animals and, secondarily, humans. Although it remains a significant disease of animals and humans in less developed parts of the world, anthrax is a very rare disease in either animals or humans in industrialized countries. The current interest in this disease is due to the heightened awareness and grave concern that Bacillus anthracis, the causative organism, might be used as a biological weapon by terrorists or in warfare. Under natural conditions, herbivores, such as cattle, sheep, horses, and goats, are the animals most commonly infected with this pathogen, although many animal species, including carnivores, are susceptible to such infection. Infection in humans occurs, under natural circumstances, by direct contact with infected animals or contaminated animal products, most often by the cutaneous route and only rarely by the respiratory or gastrointestinal routes. Anthrax is thought to have long been associated with humans and their domesticated animals. It has been suggested that the fifth and sixth plagues described in Exodus and the disease in domesticated animals and humans in Rome described by Virgil in the first century B.C. involved anthrax. The first careful clinical descriptions of anthrax in animals and humans were made only in the eighteenth century, however. Anthrax is closely associated with the origins of medical microbiology and immunology. It was the first disease for which a microbial etiology was definitively established, through the work of Robert Koch in 1877. It was also one of the first diseases for which a live bacterial vaccine was shown to be effective - in this case, by Pasteur and Greenfield. JF - Current Clinical Topics in Infectious Diseases AU - Friedlander, A M AD - Uniformed Services University of the Health Sciences, Bethesda, MD, USA Y1 - 2000 PY - 2000 DA - 2000 SP - 335 EP - 349 VL - 20 SN - 0195-3842, 0195-3842 KW - Microbiology Abstracts B: Bacteriology KW - War KW - Pathogenesis-related proteins KW - Anthrax KW - Vaccines KW - Bacillus anthracis KW - Disease transmission KW - J 02910:Miscellaneous topics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17812139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Clinical+Topics+in+Infectious+Diseases&rft.atitle=Anthrax%3A+Clinical+Features%2C+Pathogenesis%2C+and+Potential+Biological+Warfare+Threat&rft.au=Friedlander%2C+A+M&rft.aulast=Friedlander&rft.aufirst=A&rft.date=2000-01-01&rft.volume=20&rft.issue=&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Current+Clinical+Topics+in+Infectious+Diseases&rft.issn=01953842&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bacillus anthracis; Anthrax; Pathogenesis-related proteins; War; Disease transmission; Vaccines ER - TY - JOUR T1 - The Monterey Area Ship Track Experiment AN - 17732381; 4804788 AB - In June 1994 the Monterey Area Ship Track (MAST) experiment was conducted off the coast of California to investigate the processes behind anthropogenic modification of cloud albedo. The motivation for the MAST experiment is described here, as well as details of the experimental design. Measurement platforms and strategies are explained, and a summary of experiment operations is presented. The experiment produced the largest dataset to date of direct measurements of the effects of ships on the microphysics and radiative properties of marine stratocumulus clouds as an analog for the indirect effects of anthropogenic pollution on cloud albedo. JF - Journal of the Atmospheric Sciences AU - Durkee, P A AU - Noone, K J AU - Bluth, R T AD - Department of Meteorology, Naval Postgraduate School, Monterey, CA, USA Y1 - 2000 PY - 2000 DA - 2000 SP - 2523 EP - 2541 VL - 57 IS - 16 SN - 0022-4928, 0022-4928 KW - cloud albedo KW - stratocumulus KW - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Air pollution KW - Marine KW - Pollution monitoring KW - INE, USA, California, Monterey KW - INE, USA, California KW - Albedo KW - Man-induced effects KW - Cloud cover KW - Coastal waters KW - Q2 09243:Structure, mechanics and thermodynamics KW - Q5 08501:General KW - O 2070:Meteorology KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17732381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Atmospheric+Sciences&rft.atitle=The+Monterey+Area+Ship+Track+Experiment&rft.au=Durkee%2C+P+A%3BNoone%2C+K+J%3BBluth%2C+R+T&rft.aulast=Durkee&rft.aufirst=P&rft.date=2000-01-01&rft.volume=57&rft.issue=16&rft.spage=2523&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Atmospheric+Sciences&rft.issn=00224928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Air pollution; Pollution monitoring; Albedo; Man-induced effects; Cloud cover; Coastal waters; INE, USA, California, Monterey; INE, USA, California; Marine ER - TY - JOUR T1 - The Impact of Ship-Produced Aerosols on the Microstructure and Albedo of Warm Marine Stratocumulus Clouds: A Test of MAST Hypotheses 1i and 1ii AN - 17732171; 4804790 AB - Anomalously high reflectivity tracks in stratus and stratocumulus sheets associated with ships (known as ship tracks) are commonly seen in visible and near-infrared satellite imagery. Until now there have been only a limited number of in situ measurements made in ship tracks. The Monterey Area Ship Track (MAST) experiment, which was conducted off the coast of California in June 1994, provided a substantial dataset on ship emissions and their effects on boundary layer clouds. Several platforms, including the University of Washington C-131A aircraft, the Meteorological Research Flight C-130 aircraft, the National Aeronautics and Space Administration ER-2 aircraft, the Naval Research Laboratory airship, the Research Vessel Glorita, and dedicated U.S. Navy ships, participated in MAST in order to study processes governing the formation and maintenance of ship tracks. This paper tests the hypotheses that the cloud microphysical changes that produce ship tracks are due to (a) particulate emission from the ship's stack and/or (b) sea-salt particles from the ship's wake. It was found that ships powered by diesel propulsion units that emitted high concentrations of aerosols in the accumulation mode produced ship tracks. Ships that produced few particles (such as nuclear ships), or ships that produced high concentrations of particles but at sizes too small to be activated as cloud drops in typical stratocumulus (such as gas turbine and some steam-powered ships), did not produce ship tracks. Statistics and case studies, combined with model simulations, show that provided a cloud layer is susceptible to an aerosol perturbation, and the atmospheric stability enables aerosol to be mixed throughout the boundary layer, the direct emissions of cloud condensation nuclei from the stack of a diesel-powered ship is the most likely, if not the only, cause of the formation of ship tracks. There was no evidence that salt particles from ship wakes cause ship tracks. JF - Journal of the Atmospheric Sciences AU - Durkee, P A AU - Noone, K J AU - Ferek, R J AU - Johnson, D W AU - Taylor, J P AU - Garrett, T J AU - Hobbs, P V AU - Hudson, J G AU - Bretherton, C S AU - Innis, G AU - Frick, G M AU - Hoppel, WA AU - O'Dowd, C D AU - Russell, L M AD - Department of Meteorology, Naval Postgraduate School, Monterey, CA, USA Y1 - 2000 PY - 2000 DA - 2000 SP - 2554 EP - 2569 VL - 57 IS - 16 SN - 0022-4928, 0022-4928 KW - Combustion products KW - Monterey Area Ship Track KW - Ship tracks KW - ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Ships KW - Marine KW - Atmospheric particulates KW - Aerosols KW - INE, USA, California, Monterey KW - Anthropogenic factors KW - Pollution effects KW - Cloud physics KW - Chemical plumes KW - Air pollution KW - Clouds KW - Ocean-atmosphere system KW - Condensation KW - Atmospheric boundary layer KW - Nuclei KW - Diesel engines KW - Q2 09243:Structure, mechanics and thermodynamics KW - Q5 08501:General KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17732171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Atmospheric+Sciences&rft.atitle=The+Impact+of+Ship-Produced+Aerosols+on+the+Microstructure+and+Albedo+of+Warm+Marine+Stratocumulus+Clouds%3A+A+Test+of+MAST+Hypotheses+1i+and+1ii&rft.au=Durkee%2C+P+A%3BNoone%2C+K+J%3BFerek%2C+R+J%3BJohnson%2C+D+W%3BTaylor%2C+J+P%3BGarrett%2C+T+J%3BHobbs%2C+P+V%3BHudson%2C+J+G%3BBretherton%2C+C+S%3BInnis%2C+G%3BFrick%2C+G+M%3BHoppel%2C+WA%3BO%27Dowd%2C+C+D%3BRussell%2C+L+M&rft.aulast=Durkee&rft.aufirst=P&rft.date=2000-01-01&rft.volume=57&rft.issue=16&rft.spage=2554&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Atmospheric+Sciences&rft.issn=00224928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Ships; Atmospheric particulates; Aerosols; Anthropogenic factors; Pollution effects; Cloud physics; Clouds; Air pollution; Chemical plumes; Ocean-atmosphere system; Condensation; Atmospheric boundary layer; Nuclei; Diesel engines; INE, USA, California, Monterey; Marine ER - TY - JOUR T1 - Cumulative Air Quality Effects Assessment AN - 17730903; 4796587 AB - Federal agencies in the United States are required to consider the cumulative effects (CEs) of their activities combined with those of others. This requirement has placed a burden on the environmental impact assessment (EIA) process due to the technical complexities involved with cumulative effects assessment (CEA). This article presents a CEA methodology that reduces some of the inherent complexities by focusing on the cumulative influence to a single environmental resource, ambient air quality. An eight-step method is presented herein as a tool for the assessment of cumulative air quality effects. Procedures for accomplishment of the more difficult steps, such as the determination of what activities to include in the evaluation and how to determine the significance of a cumulative effect, are also included. JF - Federal Facilities Environmental Journal AU - Rumrill, J N AU - Canter, L W AD - Civil Engineer and Services School, Air Force Institute of Technology, Wright-Patterson AFB, OH, USA Y1 - 2000 PY - 2000 DA - 2000 SP - 19 EP - 38 VL - 11 IS - 3 SN - 1048-4078, 1048-4078 KW - Pollution Abstracts KW - Federal programs KW - Air quality KW - Environmental impact statements KW - Government agencies KW - P 9000:ENVIRONMENTAL ACTION KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17730903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+Facilities+Environmental+Journal&rft.atitle=Cumulative+Air+Quality+Effects+Assessment&rft.au=Rumrill%2C+J+N%3BCanter%2C+L+W&rft.aulast=Rumrill&rft.aufirst=J&rft.date=2000-01-01&rft.volume=11&rft.issue=3&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Federal+Facilities+Environmental+Journal&rft.issn=10484078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Government agencies; Environmental impact statements; Air quality; Federal programs ER - TY - JOUR T1 - Comparison of precipitation chemistry in the Central Rocky Mountains, Colorado, USA AN - 17680042; 4714838 AB - Volume-weighted mean concentrations of nitrate (NO sub(3) super(-)), ammonium (NH sub(4) super(+)), and sulfate (SO sub(4) super(2-)) in precipitation were compared at high-elevation sites in Colorado from 1992 to 1997 to evaluate emission source areas to the east and west of the Rocky Mountains. Precipitation chemistry was measured by two sampling methods, the National Atmospheric Deposition Program/National Trends Network (NADP/NTN) and snowpack surveys at maximum accumulation. Concentrations of NO sub(3) super(-) and SO sub(4) super(2-) in winter precipitation were greater on the western slope of the Rockies, and concentrations of NO sub(3) super(-) and NH sub(4) super(+) in summer precipitation were greater on the eastern slope. Summer concentrations in general were almost twice as high as winter concentrations. Seasonal weather patterns in combination with emission source areas help to explain these differences. This comparison shows that high-elevation ecosystems in Colorado are influenced by air pollution emission sources located on both sides of the Continental Divide. It also suggests that sources of nitrogen and sulfur located east of the Divide have a greater influence on precipitation chemistry in the Colorado Rockies. JF - Atmospheric Environment AU - Heuer, K AU - Tonnessen, KA AU - Ingersoll, G P AD - National Park Service-Air Resources Division, P.O. Box 25287, Denver, CO 80225-0287, USA, kristi_heuer@nps.gov Y1 - 2000 PY - 2000 DA - 2000 SP - 1713 EP - 1722 VL - 34 IS - 11 SN - 1352-2310, 1352-2310 KW - USA, Colorado, Rocky Mts. KW - Water Resources Abstracts; Pollution Abstracts KW - Air Pollution KW - Seasonal Variations KW - Emission inventories KW - Chemistry of Precipitation KW - Rainfall KW - Atmospheric chemistry KW - Air sampling KW - Sampling KW - Seasonal variations KW - SW 0880:Chemical processes KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17680042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Comparison+of+precipitation+chemistry+in+the+Central+Rocky+Mountains%2C+Colorado%2C+USA&rft.au=Heuer%2C+K%3BTonnessen%2C+KA%3BIngersoll%2C+G+P&rft.aulast=Heuer&rft.aufirst=K&rft.date=2000-01-01&rft.volume=34&rft.issue=11&rft.spage=1713&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2FS1352-2310%2899%2900430-6 LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Special issue: National Atmospheric Deposition Program (NADP). N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Emission inventories; Rainfall; Atmospheric chemistry; Air sampling; Seasonal variations; Air Pollution; Seasonal Variations; Chemistry of Precipitation; Sampling DO - http://dx.doi.org/10.1016/S1352-2310(99)00430-6 ER - TY - CONF T1 - Rapid separation of nitroaromatic compounds by solvating gas chromatography AN - 17525701; 4708001 AB - Nitroaromatic compounds such as 2,4,6-trinitrotoluene are used in the production of explosives and munitions, and are environmental contaminants as a result of such use. Conventional methods to detect these compounds have relied on liquid and gas chromatography to isolate the individual compounds which may be present at low levels in complex environmental matrices before final detection and identification. A new method, solvating gas chromatography, was used to rapidly separate 8 nitroaromatic compounds, showing improved speed relative to conventional liquid and gas chromatography methods. Solvating gas chromatography allows near real-time detection for these energetic compounds, providing improvements in their detection as environmental contaminants, and as compounds of interest to law enforcement and military organizations. JF - Drug and Chemical Toxicology AU - Smith, P A AU - Bowerbank, C R AU - Lee, M L AU - Williams, K AU - Alexander, W AU - Still, K R Y1 - 2000 PY - 2000 DA - 2000 SP - 155 EP - 160 PB - Marcel Dekker Journals, 270 Madison Ave. New York NY 10016-0602 USA VL - 23 IS - 1 KW - separation KW - nitroaromatic compounds KW - solvating gas chromatography KW - Toxicology Abstracts KW - Gas chromatography KW - X 24222:Analytical procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17525701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Chemical+Toxicology&rft.atitle=Rapid+separation+of+nitroaromatic+compounds+by+solvating+gas+chromatography&rft.au=Smith%2C+P+A%3BBowerbank%2C+C+R%3BLee%2C+M+L%3BWilliams%2C+K%3BAlexander%2C+W%3BStill%2C+K+R&rft.aulast=Smith&rft.aufirst=P&rft.date=2000-01-01&rft.volume=23&rft.issue=1&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Drug+and+Chemical+Toxicology&rft.issn=01480545&rft_id=info:doi/10.1081%2FDCT-100100108 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1081/DCT-100100108 ER - TY - JOUR T1 - Airborne Aldehydes from Heating Rosin Core Solder and Liquid Rosin Flux to Soldering Temperatures AN - 17499124; 4690571 AB - Gas phase aldehydes produced from heating rosin core solder and liquid rosin flux to temperatures commonly used in soldering were trapped on sampling tubes containing XAD-2 resin coated with the derivatizing agent 2-hydroxymethylpiperidine. Analysis of the resulting oxazolidine derivatives was performed using gas chromatography/mass spectrometry (GC/MS). The observed aldehyde derivatives included formaldehyde, acetaldehyde, propionaldehyde, acrolein, isobutyraldehyde, butyraldehyde, isovaleraldehyde, valeraldehyde, furfural, hexanal, cyclohexane carboxaldehyde and other unidentified compounds likely to be aldehyde isomers. Formaldehyde, acetaldehyde, and benzaldehyde were detected in blank samples. By comparison with an internal standard, a sample produced by drawing air with contaminants derived by heating rosin core solder through a sampling tube contained levels of formaldehyde and acetaldehyde much greater than seen in sampling tube blanks. Benzaldehyde was not shown to be present at a significantly greater level in samples from heating rosin core solder than in blanks prepared using the same analysis protocol. The use of National Institute of Occupational Safety and Health (NIOSH) method 2539 extraction procedures produced blanks with levels of formaldehyde significantly lower than with a modified extraction method (methylene chloride, no sonication). The modified extraction method produced significantly lower benzaldehyde levels in blanks compared with the NIOSH extraction method using toluene and sonication of sampling sorbent tubes. JF - American Industrial Hygiene Association Journal AU - Smith, P A AU - Bowerbank, C R AU - Lee, M L AU - Solberg, M AU - Drown, D B AU - Alexander, W AU - Still, K R AD - Uniformed Services University of the Health Sciences, Department of Preventive Medicine and Biometrics, Bethesda, MD, USA Y1 - 2000 PY - 2000 DA - 2000 SP - 95 EP - 101 VL - 61 IS - 1 SN - 0002-8894, 0002-8894 KW - soldering KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Air sampling KW - Aldehydes KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17499124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+Journal&rft.atitle=Airborne+Aldehydes+from+Heating+Rosin+Core+Solder+and+Liquid+Rosin+Flux+to+Soldering+Temperatures&rft.au=Smith%2C+P+A%3BBowerbank%2C+C+R%3BLee%2C+M+L%3BSolberg%2C+M%3BDrown%2C+D+B%3BAlexander%2C+W%3BStill%2C+K+R&rft.aulast=Smith&rft.aufirst=P&rft.date=2000-01-01&rft.volume=61&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+Journal&rft.issn=00028894&rft_id=info:doi/10.1202%2F0002-8894%282000%290612.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Aldehydes; Air sampling; Occupational exposure DO - http://dx.doi.org/10.1202/0002-8894(2000)061<0095:AAFHRC>2.0.CO;2 ER - TY - JOUR T1 - Changes in the Forest Landscape of the Charles C. Deam Wilderness, Southern Indiana, 1939-1990 AN - 17481692; 4681499 AB - We used aerial photographs from 1939, 1974, and 1990 to examine how land cover has changed on the 5,286-ha Charles C. Deam Wilderness of Hoosier National Forest over this time span. Digital elevation models were used to examine changes in land-cover class (closed-canopy forest, open forest, agriculture/old-field, clearcut, and pine plantation) within each land type (flat uplands, bottoms, mesic slopes, and dry slopes). In 1939 most of the Deam Wilderness lands consisted of agriculture/old fields (33%) and open forest (25.6%), with only 41.4% in closed-canopy forest. By 1974 most of the wilderness area had become closed-canopy forest (77.5%), and an even greater proportion was in that class in 1990 (86.3%). Since 1939 the forest of the Deam Wilderness has become much less fragmented with larger patch sizes, less total edge, and more total core area (area within a patch > 50 m from the edge). In 1939 land cover varied by land type: flat uplands and bottoms had the highest proportion of agriculture and old-fields (42.4% and 63.3%, respectively), and dry and mesic slopes had the highest proportion of open forests (30.2% and 28.3%, respectively). By 1974 closed-canopy forest was the dominant land cover on all land types. JF - Natural Areas Journal AU - Jenkins, MA AU - Parker, G R AD - Great Smoky Mountains National Park, Twin Creeks Natural Resource Center, 1314 Cherokee Orchard Road, Gatlinburg, TN 37738, USA, mike_jenkins@nps.gov Y1 - 2000/01// PY - 2000 DA - Jan 2000 SP - 46 EP - 55 VL - 20 IS - 1 SN - 0885-8608, 0885-8608 KW - USA, Indiana KW - Ecology Abstracts KW - Vegetation patterns KW - Historical ecology KW - Forests KW - D 04125:Temperate forests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17481692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Natural+Areas+Journal&rft.atitle=Changes+in+the+Forest+Landscape+of+the+Charles+C.+Deam+Wilderness%2C+Southern+Indiana%2C+1939-1990&rft.au=Jenkins%2C+MA%3BParker%2C+G+R&rft.aulast=Jenkins&rft.aufirst=MA&rft.date=2000-01-01&rft.volume=20&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Natural+Areas+Journal&rft.issn=08858608&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Forests; Historical ecology; Vegetation patterns ER - TY - JOUR T1 - Composite Ship Track Characteristics AN - 17033416; 4804789 AB - The physical and radiative properties of a composite ship track are described from the analysis of 131 ship-ship track correlation pairs collected during the Monterey Area Ship Track experiment. The significant variability of ship tracks around their average characteristics is also described. The nominal environmental conditions for the ship track set are also described. The composite ship track is 296 plus or minus 233 km long, 7.3 plus or minus 6 h old, and averages 9 plus or minus 5 km wide. The ship is, on the average, 16 plus or minus 8 km from of the head of the ship track along the relative wind vector and corresponds to a time of 25 plus or minus 15 min. The set of ship tracks examined in this study formed in marine boundary layers that were between 300 and 750 m deep, and no tracks formed in boundary layers above 800 m. The tracks form in regions of high relative humidity, small air-sea temperature differences, and moderate winds (average of 7.7 plus or minus 3.1 m s super(-1)). The ambient cloud reflectance in advanced very high resolution radiometer channel 3 (3.7- mu m wavelength) is 11 plus or minus 4%, while the composite ship track value is 14 plus or minus 5%. The relative track brightness is 7 plus or minus 26% and 37 plus or minus 34% for 0.63- and 3.7- mu m wavelengths, respectively. JF - Journal of the Atmospheric Sciences AU - Durkee, P A AU - Chartier, R E AU - Brown, A AU - Trehubenko, E J AU - Rogerson, S D AU - Skupniewicz, C AU - Nielsen, KE AU - Platnick, S AU - King, MD AD - Department of Meteorology, Naval Postgraduate School, Monterey, CA, USA Y1 - 2000 PY - 2000 DA - 2000 SP - 2542 EP - 2553 VL - 57 IS - 16 SN - 0022-4928, 0022-4928 KW - Combustion products KW - Monterey Area Ship Track KW - Ship tracks KW - Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Ships KW - Marine KW - Aerosols KW - INE, USA, California, Monterey KW - Reflectance KW - Fuels KW - Anthropogenic factors KW - Pollution effects KW - Humidity KW - Cloud physics KW - Air pollution KW - Radiometers KW - Clouds KW - Chemical plumes KW - Air-water temperature difference KW - Atmospheric optical phenomena KW - Ocean-atmosphere system KW - Atmospheric boundary layer KW - Q2 09243:Structure, mechanics and thermodynamics KW - Q5 08501:General KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17033416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Atmospheric+Sciences&rft.atitle=Composite+Ship+Track+Characteristics&rft.au=Durkee%2C+P+A%3BChartier%2C+R+E%3BBrown%2C+A%3BTrehubenko%2C+E+J%3BRogerson%2C+S+D%3BSkupniewicz%2C+C%3BNielsen%2C+KE%3BPlatnick%2C+S%3BKing%2C+MD&rft.aulast=Durkee&rft.aufirst=P&rft.date=2000-01-01&rft.volume=57&rft.issue=16&rft.spage=2542&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Atmospheric+Sciences&rft.issn=00224928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Ships; Aerosols; Reflectance; Fuels; Anthropogenic factors; Humidity; Pollution effects; Cloud physics; Chemical plumes; Clouds; Radiometers; Air pollution; Air-water temperature difference; Ocean-atmosphere system; Atmospheric optical phenomena; Atmospheric boundary layer; INE, USA, California, Monterey; Marine ER - TY - JOUR T1 - Treatment of Helicobacter pylori infection in rhesus monkeys using a novel antiadhesion compound. AN - 69321188; 10579973 AB - Helicobacter pylori can be eradicated by administration of antimicrobials, but resistant strains have emerged, and there is a need for novel therapeutic approaches against this infection. This study aimed to determine the safety and efficacy of 3'-sialyllactose sodium salt (3'SL), an oligosaccharide that occurs naturally in human and bovine milk and that can inhibit the adhesion of H. pylori to human epithelial cells in vitro. Twelve H. pylori-positive rhesus monkeys were given 3'SL, either alone (regimens 1 and 2; n = 6) or in combination with omeprazole (regimen 3; n = 4), or bismuth subsalicylate (regimen 4; n = 6). Videogastroscopies were performed before, during, and after treatment, and gastric biopsy specimens were obtained for quantitative cultures and histology. The H. pylori strains colonizing the animals were genotyped. After regimen 1 or 2, 2 of 6 animals were cured permanently, and a third animal was transiently cleared. The 3 other animals remained persistently colonized and did not respond to regimen 3. Regimen 4 resulted in transient decreases in colony counts in 3 of 6 other animals. Gastritis was suppressed only in the 2 animals who became persistently H. pylori negative. There was no apparent relation between 3'SL efficacy and any of the H. pylori tested genotypes. No side effects were observed in any of the animals receiving 3'SL. Antiadhesive therapy is safe; it can cure or decrease H. pylori colonization in some rhesus monkeys, but the addition of a proton pump inhibitor or bismuth subsalicylate does not increase cure rate. JF - Gastroenterology AU - Mysore, J V AU - Wigginton, T AU - Simon, P M AU - Zopf, D AU - Heman-Ackah, L M AU - Dubois, A AD - Laboratory of Gastrointestinal and Liver Studies, Digestive Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 1316 EP - 1325 VL - 117 IS - 6 SN - 0016-5085, 0016-5085 KW - Anti-Bacterial Agents KW - 0 KW - Anti-Ulcer Agents KW - Organometallic Compounds KW - Proton Pump Inhibitors KW - Salicylates KW - Sialic Acids KW - N-acetylneuraminoyllactose KW - 3J7TAL60G3 KW - bismuth subsalicylate KW - 62TEY51RR1 KW - Lactose KW - J2B2A4N98G KW - Bismuth KW - U015TT5I8H KW - Abridged Index Medicus KW - Index Medicus KW - Genotype KW - Drug Therapy, Combination KW - Animals KW - Bismuth -- therapeutic use KW - Humans KW - Disease Models, Animal KW - Salicylates -- therapeutic use KW - Macaca mulatta KW - Organometallic Compounds -- therapeutic use KW - Liver Function Tests KW - Sialic Acids -- therapeutic use KW - Sialic Acids -- adverse effects KW - Anti-Bacterial Agents -- therapeutic use KW - Lactose -- therapeutic use KW - Lactose -- analogs & derivatives KW - Anti-Ulcer Agents -- adverse effects KW - Helicobacter Infections -- drug therapy KW - Helicobacter pylori -- genetics KW - Anti-Bacterial Agents -- adverse effects KW - Lactose -- adverse effects KW - Anti-Ulcer Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69321188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Treatment+of+Helicobacter+pylori+infection+in+rhesus+monkeys+using+a+novel+antiadhesion+compound.&rft.au=Mysore%2C+J+V%3BWigginton%2C+T%3BSimon%2C+P+M%3BZopf%2C+D%3BHeman-Ackah%2C+L+M%3BDubois%2C+A&rft.aulast=Mysore&rft.aufirst=J&rft.date=1999-12-01&rft.volume=117&rft.issue=6&rft.spage=1316&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-12-22 N1 - Date created - 1999-12-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Gastroenterology. 2000 Nov;119(5):1414-6 [11185463] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Short repeats and IS elements in the extremely radiation-resistant bacterium Deinococcus radiodurans and comparison to other bacterial species AN - 17477560; 4676284 AB - Computer analysis of the complete genome of Deinococcus radiodurans R1 has shown that the number of insertion sequences (ISs) and small noncoding repeats (SNRs) it contains is very high, and comparable with those of Escherichia coli. IS elements and several families of SNRs are described, together with their possible function in the D. radiodurans genome. JF - Research in Microbiology AU - Makarova, K S AU - Wolf, YI AU - White, O AU - Minton, K AU - Daly, MJ AD - Department of Pathology, Rm. B3153, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA, daly@usuhs.mil Y1 - 1999/12// PY - 1999 DA - Dec 1999 SP - 711 EP - 724 VL - 150 IS - 9-10 SN - 0923-2508, 0923-2508 KW - small noncoding repeats KW - genomes KW - resistance KW - 7 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - Repeated sequence KW - Radiation KW - Escherichia coli KW - Insertion sequences KW - Deinococcus radiodurans KW - G 07204:Transposons/insertion sequences KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17477560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Microbiology&rft.atitle=Short+repeats+and+IS+elements+in+the+extremely+radiation-resistant+bacterium+Deinococcus+radiodurans+and+comparison+to+other+bacterial+species&rft.au=Makarova%2C+K+S%3BWolf%2C+YI%3BWhite%2C+O%3BMinton%2C+K%3BDaly%2C+MJ&rft.aulast=Makarova&rft.aufirst=K&rft.date=1999-12-01&rft.volume=150&rft.issue=9-10&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Research+in+Microbiology&rft.issn=09232508&rft_id=info:doi/10.1016%2FS0923-2508%2899%2900121-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Deinococcus radiodurans; Escherichia coli; Insertion sequences; Genomes; Repeated sequence; Radiation DO - http://dx.doi.org/10.1016/S0923-2508(99)00121-7 ER - TY - JOUR T1 - Spiders in conservation planning: a survey of US natural heritage programs AN - 17452308; 4655119 AB - Although spiders play important roles in terrestrial ecosystems and are negatively impacted by human activity, they have received little attention from the US conservation community. Information gaps may prohibit the inclusion of spiders in conservation planning. Conservation priority setting, environmental review and local land-use planning activities in the US increasingly rely on information compiled by the Natural Heritage Network. A review of heritage database content and a survey of natural heritage programs both indicate a paucity of compiled data on the US spider fauna. Heritage programs are probably hampered by the unavailability of current species checklists, identification services and keys, and a general unfamiliarity with the fauna. Clearly, further development of information on rare or imperiled spiders will depend on increased communication and collaboration with arachnologists. JF - Journal of Insect Conservation AU - Skerl, K L AD - National Park Service, Cuyahoga Valley National Recreation Area, 15610 Vaughn Rd., Brecksville, OH 44141, USA, kevin_skerl@nps.gov Y1 - 1999/12// PY - 1999 DA - Dec 1999 SP - 341 EP - 347 VL - 3 IS - 4 SN - 1366-638X, 1366-638X KW - Araneae KW - USA KW - Ecology Abstracts; Entomology Abstracts KW - Planning KW - Conservation KW - Z 05205:Populations & general ecology KW - D 04705:Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17452308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Insect+Conservation&rft.atitle=Spiders+in+conservation+planning%3A+a+survey+of+US+natural+heritage+programs&rft.au=Skerl%2C+K+L&rft.aulast=Skerl&rft.aufirst=K&rft.date=1999-12-01&rft.volume=3&rft.issue=4&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Journal+of+Insect+Conservation&rft.issn=1366638X&rft_id=info:doi/10.1023%2FA%3A1009641620689 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Special issue: Issues in spider conservation. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Conservation; Planning DO - http://dx.doi.org/10.1023/A:1009641620689 ER - TY - JOUR T1 - Predictors of Occupational Low Back Disability: Implications for Secondary Prevention AN - 17420364; 4647053 AB - Over the past decade, studies have identified a combination of demographic, physical/medical, ergonomic, and psychosocial factors in the development of work disability related to occupational low back pain. Using such data on disability risk factors, investigators have begun to develop risk identification and disability prevention programs. As part of an ongoing effort to develop a secondary prevention program, the present case-control study identified the relative contribution of demographic, physical demand, physical fitness, as well as occupational and individual psychosocial variables to back-related work disability in the US Army. Soldiers (n = 174) diagnosed with a lumbosacral strain and medically discharged from the Army were compared with non-disabled controls (n = 173). Dependent measures were obtained from the US Army Health Risk Appraisal (HRA). For cases, these data pre-dated disability determination by 1 to 3 years. For controls, the HRA was completed during the same time period. Significant predictors of low back disability were: age (odds ratio [OR] = 1.13 per year), lower rank (E2/E3) (OR = 4.08/OR = 3.02), infrequent aerobic exercise (OR = 2.2), higher work stress (OR = 2.71), worries (OR = 2.17), and lower social support (OR = 5.07). The model correctly classified 73.13% of all subjects. These results highlight the importance of considering age, status level in the organization, frequency of aerobic exercise, occupational stress, general worries, and social support for the early detection of soldiers at increased risk for back-related disability. Additionally, the findings support past research indicating the multivariate nature of work disability and emphasize the importance of considering such factors in future secondary prevention efforts. JF - Journal of Occupational and Environmental Medicine AU - Feuerstein, M AU - Berkowitz, S M AU - Huang, G D AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA, mfeuerstein@usuhs.mil Y1 - 1999/12// PY - 1999 DA - Dec 1999 SP - 1024 VL - 41 IS - 12 SN - 1076-2752, 1076-2752 KW - back pain KW - disabilities KW - physical training KW - Health & Safety Science Abstracts KW - Age KW - Stress KW - Ergonomics KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17420364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Predictors+of+Occupational+Low+Back+Disability%3A+Implications+for+Secondary+Prevention&rft.au=Feuerstein%2C+M%3BBerkowitz%2C+S+M%3BHuang%2C+G+D&rft.aulast=Feuerstein&rft.aufirst=M&rft.date=1999-12-01&rft.volume=41&rft.issue=12&rft.spage=1024&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ergonomics; Occupational health; Age; Stress ER - TY - JOUR T1 - Decreased adherence of enterohemorrhagic Escherichia coli to HEp-2 cells in the presence of antibodies that recognize the C-terminal region of intimin AN - 17347281; 4640494 AB - Antiserum raised against intimin from enterohemorrhagic Escherichia coli (EHEC) O157:H7 strain 86-24 has been shown previously by our laboratory to inhibit adherence of this strain to HEp-2 cells. In the present study, we sought to identify the region(s) of intimin important for the effect of anti-intimin antisera on EHEC adherence and to determine whether antisera raised against intimin from an O157:H7 strain could reduce adherence of other strains. Compared to preimmune serum controls, polyclonal sera raised against the histidine-tagged intimin protein RIHisEae (intimin sub(O157)) or against His-tagged C-terminal fragments of intimin from strain 86-24 reduced adherence of this strain. Furthermore, an antibody fraction purified from the anti-RIHisEae serum that contained antibodies to the C-terminal third of intimin, the putative receptor-binding domain, also reduced adherence of strain 86-24, but a purified fraction containing antibodies to the N-terminal two-thirds of intimin did not inhibit adherence. The polyclonal anti-intimin sub(O157) serum raised against RIHisEae inhibited, to different degrees, the adherence of another O157:H7 strain, an EHEC O55:H7 strain, one of two independent EHEC O111:NM isolates tested, and one of two EHEC O26:H11 strains tested. Adherence of the other O26:H11 and O111:NM strains and an EPEC O127:H6 strain was not reduced. Finally, immunoblot analysis indicated a correlation between the antigenic divergence in the C-terminal third of intimins from different strains and the capacity of anti-intimin sub(O157) antiserum to reduce adherence of heterologous strains. Taken together, these data suggest that intimin sub(O157) could be used as an immunogen to elicit adherence-blocking antibodies against O157:H7 strains and closely-related EHEC. JF - Infection and Immunity AU - Gansheroff, L J AU - Wachtel, M R AU - O'Brien, AD AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA, aobrien@usuhs.mil Y1 - 1999/12// PY - 1999 DA - Dec 1999 SP - 6409 EP - 6417 VL - 67 IS - 12 SN - 0019-9567, 0019-9567 KW - Intimin KW - Microbiology Abstracts B: Bacteriology KW - Antisera KW - Antibodies KW - C-Terminus KW - Escherichia coli KW - Membrane proteins KW - Hemorrhagic enteritis KW - Cell adhesion KW - J 02831:Techniques and reagents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17347281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Decreased+adherence+of+enterohemorrhagic+Escherichia+coli+to+HEp-2+cells+in+the+presence+of+antibodies+that+recognize+the+C-terminal+region+of+intimin&rft.au=Gansheroff%2C+L+J%3BWachtel%2C+M+R%3BO%27Brien%2C+AD&rft.aulast=Gansheroff&rft.aufirst=L&rft.date=1999-12-01&rft.volume=168&rft.issue=11&rft.spage=1154&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/10.1176%2Fappi.ajp.2011.11020281 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; C-Terminus; Antibodies; Hemorrhagic enteritis; Membrane proteins; Antisera; Cell adhesion ER - TY - JOUR T1 - Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse. AN - 69301527; 10570150 AB - The mammalian anx7 gene codes for a Ca(2+)-activated GTPase, which supports Ca(2+)/GTP-dependent secretion events and Ca(2+) channel activities in vitro and in vivo. To test whether anx7 might be involved in Ca(2+) signaling in secreting pancreatic beta cells, we knocked out the anx7 gene in the mouse and tested the insulin-secretory properties of the beta cells. The nullizygous anx7 (-/-) phenotype is lethal at embryonic day 10 because of cerebral hemorrhage. However, the heterozygous anx7 (+/-) mouse, although expressing only low levels of ANX7 protein, is viable and fertile. The anx7 (+/-) phenotype is associated with a substantial defect in insulin secretion, although the insulin content of the islets, is 8- to 10-fold higher in the mutants than in the normal littermate control. We infer from electrophysiological studies that both glucose-stimulated secretion and voltage-dependent Ca(2+) channel functions are normal. However, electrooptical recordings indicate that the (+/-) mutation has caused a change in the ability of inositol 1,4,5-trisphosphate (IP(3))-generating agonists to release intracellular calcium. The principle molecular consequence of lower anx7 expression is a profound reduction in IP(3) receptor expression and function in pancreatic islets. The profound increase in islets, beta cell number, and size may be a means of compensating for less efficient insulin secretion by individual defective pancreatic beta cells. This is a direct demonstration of a connection between glucose-activated insulin secretion and Ca(2+) signaling through IP(3)-sensitive Ca(2+) stores. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Srivastava, M AU - Atwater, I AU - Glasman, M AU - Leighton, X AU - Goping, G AU - Caohuy, H AU - Miller, G AU - Pichel, J AU - Westphal, H AU - Mears, D AU - Rojas, E AU - Pollard, H B AD - Department of Anatomy, Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA. msrivastava@usuhs.mil Y1 - 1999/11/23/ PY - 1999 DA - 1999 Nov 23 SP - 13783 EP - 13788 VL - 96 IS - 24 SN - 0027-8424, 0027-8424 KW - Annexin A7 KW - 0 KW - Calcium Channels KW - Inositol 1,4,5-Trisphosphate Receptors KW - Insulin KW - Receptors, Cytoplasmic and Nuclear KW - Inositol 1,4,5-Trisphosphate KW - 85166-31-0 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - Glucose KW - IY9XDZ35W2 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Glucose -- metabolism KW - Mice KW - Electrophysiology KW - Islets of Langerhans -- pathology KW - Mutagenesis KW - Mice, Knockout KW - Phenotype KW - Calcium -- metabolism KW - Hyperplasia KW - Hypertrophy KW - Genetic Vectors KW - Cytosol KW - Islets of Langerhans -- cytology KW - Immunohistochemistry KW - Islets of Langerhans -- metabolism KW - Cell Line KW - GTP Phosphohydrolases -- physiology KW - Annexin A7 -- physiology KW - GTP Phosphohydrolases -- genetics KW - Insulin -- secretion KW - Receptors, Cytoplasmic and Nuclear -- biosynthesis KW - Calcium Channels -- biosynthesis KW - Calcium Signaling KW - Annexin A7 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69301527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Defects+in+inositol+1%2C4%2C5-trisphosphate+receptor+expression%2C+Ca%282%2B%29+signaling%2C+and+insulin+secretion+in+the+anx7%28%2B%2F-%29+knockout+mouse.&rft.au=Srivastava%2C+M%3BAtwater%2C+I%3BGlasman%2C+M%3BLeighton%2C+X%3BGoping%2C+G%3BCaohuy%2C+H%3BMiller%2C+G%3BPichel%2C+J%3BWestphal%2C+H%3BMears%2C+D%3BRojas%2C+E%3BPollard%2C+H+B&rft.aulast=Srivastava&rft.aufirst=M&rft.date=1999-11-23&rft.volume=96&rft.issue=24&rft.spage=13783&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-06 N1 - Date created - 2000-01-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem J. 1985 May 1;227(3):965-9 [3890834] Biochem J. 1983 Jul 15;214(1):225-30 [6311175] Biochem J. 1997 Mar 1;322 ( Pt 2):365-71 [9065751] Cell Calcium. 1997 Mar;21(3):257-61 [9105735] Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14912-7 [9405713] N Engl J Med. 1999 Apr 1;340(13):1035-6 [10099148] J Cardiovasc Pharmacol. 1986;8 Suppl 8:S65-70 [2433529] Diabetes. 1988 Sep;37(9):1294-300 [2842212] Biochim Biophys Acta. 1991 Mar 26;1088(3):429-32 [1826615] J Biol Chem. 1991 Sep 15;266(26):17509-15 [1832674] Cell Tissue Res. 1992 Aug;269(2):323-30 [1423500] Biochem J. 1993 Feb 1;289 ( Pt 3):735-41 [7916616] Endocrinology. 1994 Apr;134(4):1771-81 [8137742] Biochim Biophys Acta. 1994 Apr 5;1197(1):63-93 [8155692] Biochemistry. 1994 Jun 7;33(22):6888-901 [7515686] Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7777-81 [7914371] Biochem J. 1994 Aug 1;301 ( Pt 3):835-45 [8053909] J Biol Chem. 1994 Nov 4;269(44):27167-70 [7961623] Science. 1995 Apr 21;268(5209):426-9 [7716548] Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2745-8 [8610112] Biochem J. 1996 Jun 15;316 ( Pt 3):729-35 [8670145] Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10797-802 [8855260] J Biol Chem. 1978 Apr 25;253(8):2858-66 [632306] J Physiol. 1978 May;278:117-39 [353252] Diabetologia. 1981 Nov;21(5):470-5 [7028561] Trans Assoc Am Physicians. 1982;95:299-309 [6190296] J Biol Chem. 1986 Dec 15;261(35):16284-7 [3023346] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recombinant vaccinia viruses. Design, generation, and isolation AN - 815536308; 13859750 AB - The technologies of recombinant gene expression have greatly enhanced the structural and functional analyses of genetic elements and proteins. Vaccinia virus, a large double-stranded DNA virus and the prototypic and best characterized member of the poxvirus family, has been an instrumental tool among these technologies and the recombinant vaccinia virus system has been widely employed to express genes from eukaryotic, prokaryotic, and viral origins. Vaccinia virus is also the prototype live viral vaccine and serves as the basis for well established viral vectors which have been successfully evaluated as human and animal vaccines for infectious diseases and as anticancer vaccines in a variety of animal model systems. Vaccinia virus technology has also been instrumental in a number of unique applications, from the discovery of new viral receptors to the synthesis and assembly of other viruses in culture. Here we provide a simple and detailed outline of the processes involved in the generation of a typical recombinant vaccinia virus, along with an up to date review of relevant literature. JF - Molecular Biotechnology AU - Broder, Christopher C AU - Earl, Patricia L AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 20814, Bethesda, Maryland Y1 - 1999/11// PY - 1999 DA - Nov 1999 SP - 223 EP - 245 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 13 IS - 3 SN - 1073-6085, 1073-6085 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Vaccinia virus KW - Infectious diseases KW - Poxvirus KW - Structure-function relationships KW - Vaccinia KW - Reviews KW - Animal models KW - Vaccines KW - V 22320:Replication KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815536308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biotechnology&rft.atitle=Recombinant+vaccinia+viruses.+Design%2C+generation%2C+and+isolation&rft.au=Broder%2C+Christopher+C%3BEarl%2C+Patricia+L&rft.aulast=Broder&rft.aufirst=Christopher&rft.date=1999-11-01&rft.volume=13&rft.issue=3&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Molecular+Biotechnology&rft.issn=10736085&rft_id=info:doi/10.1385%2FMB%3A13%3A3%3A223 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene expression; Infectious diseases; Vaccinia; Structure-function relationships; Reviews; Animal models; Vaccines; Vaccinia virus; Poxvirus DO - http://dx.doi.org/10.1385/MB:13:3:223 ER - TY - JOUR T1 - Ontogenetic Habitat Shifts of Juvenile Bear Lake Sculpin AN - 17480611; 4678726 AB - Bear lake sculpin Cottus extensus exhibit ontogenetic habitat shifts during their initial year of life. Distribution and habitat switching was measured with bimonthly bottom-trawl surveys repeated throughout the summer. Patterns of daily growth increments on otoliths were used to measure the history of habitat residence, individual size at the time of the habitat switch, and habitat-specific growth rates. Laboratory experiments and known-age fish confirmed daily increment formation of otoliths. After dispersing during an initial pelagic larval stage, postlarval juveniles settled in both the warm, food-rich littoral zone and the cold, unproductive profundal zone. During summer, initial profundal-zone inhabitants underwent a unidirectional habitat shift to the more productive littoral zone. Fish that moved to the littoral zone grew twice as fast as those in the profundal zone and encountered little apparent predation mortality risk there. Habitat shifts were therefore consistent with both growth optimization and predatory avoidance. However, shifts occurred at a wide range of body sizes throughout the summer. The large spatial scale of the lake, limited swimming ability of juvenile fish, diel migratory behavior, and lack of complex habitat structure may preclude shifts at discrete body sizes for this species. JF - Transactions of the American Fisheries Society AU - Ruzycki, J R AU - Wurtsbaugh, WA AD - National Park Service, Aquatic Resources Center, Post Office Box 168, Yellowstone National Park, Wyoming 82190, USA, jim_ruzycki@nps.gov Y1 - 1999/11// PY - 1999 DA - Nov 1999 SP - 1201 EP - 1212 VL - 128 IS - 6 SN - 0002-8487, 0002-8487 KW - Bear lake sculpin KW - Juveniles KW - Ecology Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Age KW - Lakes KW - Otoliths KW - Predation KW - Cottus extensus KW - Surveys KW - Ontogeny KW - Habitat selection KW - D 04668:Fish KW - Q1 08423:Behaviour UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17480611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+the+American+Fisheries+Society&rft.atitle=Ontogenetic+Habitat+Shifts+of+Juvenile+Bear+Lake+Sculpin&rft.au=Ruzycki%2C+J+R%3BWurtsbaugh%2C+WA&rft.aulast=Ruzycki&rft.aufirst=J&rft.date=1999-11-01&rft.volume=128&rft.issue=6&rft.spage=1201&rft.isbn=&rft.btitle=&rft.title=Transactions+of+the+American+Fisheries+Society&rft.issn=00028487&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Otoliths; Predation; Ontogeny; Habitat selection; Lakes; Age; Surveys; Cottus extensus ER - TY - JOUR T1 - A system for identifying post-invasion functions of invasion genes: requirements for the Mxi-Spa type III secretion pathway of Shigella flexneri in intercellular dissemination AN - 17412672; 4639510 AB - Invasion and intercellular spread are hallmarks of Shigella pathogenicity. Invasion of the eukaryotic cell cytosol requires a type III secretion system (Mxi-Spa) and its cognate set of secreted Ipa invasins. Once intracellular, the IcsA protein directs a form of actin-based motility that helps to drive intracellular bacterial movement, formation of cellular protrusions and cell-to-cell spread. Work in our laboratory has focused on identifying additional factors required for this intercellular form of dissemination. In this study, we sought to identify novel contributions of the type III secretion pathway to post-invasion-specific processes, distinct from its previously characterized roles in invasion. Studies of post-invasion Ipa and Mxi-Spa functions are complicated by an absolute requirement for these virulence proteins in invasion. To circumvent this problem, we developed a system called TIER (for test of intracellular expression requirements), whereby specific ipa, mxi or spa loci are transiently expressed before infection of tissue culture cell monolayers (thus supporting invasion), but then repressed after invasion in the intracellular environment. Such invasive type III secretion mutants (called TIER mutants) were severely restricted in their ability to spread intercellularly and form plaques in confluent tissue culture cell monolayers. Intercellular spread defects were associated with the repression of most type III pathway components examined, including structural (MxiM and Spa33), secreted effector (IpaB, IpaC and IpaD) and regulatory elements (VirF and VirB). A kinetic analysis of bacterial growth in L2 cell monolayers showed that each of the TIER mutants was defective with respect to long-term intracellular proliferation and viability. Examination of TIER mutant-infected monolayers by electron microscopy revealed that the type III pathway was required for a late step in intercellular spread - bacterial escape from protrusion-derived, double-membrane-bound vacuoles. The TIER mutants were eventually degraded in a process involving vacuolar acidification. Based on these findings, we propose that Ipa secretion via Mxi-Spa is required in the protrusion vacuole for double-membrane lysis. JF - Molecular Microbiology AU - Schuch, R AU - Sandlin, R C AU - Maurelli, A T AD - Department of Microbiology and Immunology, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA, amaurelli@usuhs.mil Y1 - 1999/11// PY - 1999 DA - Nov 1999 SP - 675 EP - 689 VL - 34 IS - 4 SN - 0950-382X, 0950-382X KW - IcsA protein KW - IcsB protein KW - IcsC protein KW - IcsD protein KW - Ipa protein KW - MxiM protein KW - Spa33 protein KW - VirB protein KW - VirF protein KW - ipa gene KW - mxi gene KW - spa gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Secretion KW - Shigella KW - G 07320:Bacterial genetics KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17412672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=A+system+for+identifying+post-invasion+functions+of+invasion+genes%3A+requirements+for+the+Mxi-Spa+type+III+secretion+pathway+of+Shigella+flexneri+in+intercellular+dissemination&rft.au=Schuch%2C+R%3BSandlin%2C+R+C%3BMaurelli%2C+A+T&rft.aulast=Schuch&rft.aufirst=R&rft.date=1999-11-01&rft.volume=34&rft.issue=4&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Shigella; Secretion ER - TY - JOUR T1 - Experimental gonococcal genital tract infection and opacity protein expression in estradiol-treated mice AN - 17345387; 4629407 AB - The development of effective prophylactic agents against gonorrhea and the study of adaptation by Neisseria gonorrhoeae to the urogenital mucosa are hindered by the lack of a well-established animal model of gonococcal genital tract infection. Here, a murine model of long-term gonococcal genital tract infection is described. Female BALB/c mice were treated with 17- beta -estradiol and inoculated intravaginally with wild-type gonococcal strain FA1090 or MS11. N. gonorrhoeae was recovered from vaginal swabs for an average of 12 to 13 days following inoculation with 10 super(6) CFU of either strain. Inflammation occurred in over 80% of infected mice, and diplococci were associated with epithelial cells and neutrophils in stained vaginal smears. Ascended infection occurred in 17 to 20% of mice inoculated with strain FA1090. An outbred mouse strain (SLC:ddY) previously reported to be naturally susceptible to N. gonorrhoeae was also tested; however, as with BALB/c mice, estradiol was required for prolonged infection. Although piliation was not maintained during experimental murine infection, 46 to 100% of vaginal isolates from four of eight BALB/c mice and three of four SLC:ddY mice expressed one or more opacity (Opa) proteins within 4 days after inoculation with an Opa-negative variant of strain FA1090. The observed selection for and/or induction of gonococcal Opa protein expression during murine infection appears to parallel events that occur during experimental urethritis in volunteers. JF - Infection and Immunity AU - Jerse, A E AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA, ajerse@mxb.usuhs.mil Y1 - 1999/11// PY - 1999 DA - Nov 1999 SP - 5699 EP - 5708 VL - 67 IS - 11 SN - 0019-9567, 0019-9567 KW - Opa proteins KW - Microbiology Abstracts B: Bacteriology KW - Animal models KW - Genital tract KW - Estradiol KW - Neisseria gonorrhoeae KW - J 02847:Genitourinary tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17345387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Experimental+gonococcal+genital+tract+infection+and+opacity+protein+expression+in+estradiol-treated+mice&rft.au=Jerse%2C+A+E&rft.aulast=Jerse&rft.aufirst=A&rft.date=1999-11-01&rft.volume=67&rft.issue=11&rft.spage=5699&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neisseria gonorrhoeae; Estradiol; Animal models; Genital tract ER - TY - JOUR T1 - Progressive alterations in circular smooth muscle contractility in TNBS-induced colitis in rats. AN - 70842895; 10520166 AB - The present study was designed to investigate inflammation-induced changes in smooth muscle responses to acetylcholine and the tachykinins that may contribute to the abnormal motility associated with inflammatory bowel disease. Colitis was induced in male Sprague-Dawley rats by intrarectal administration of trinitrobenzenesulphonic acid in ethanol. After either 4 h (acute) or 7 days (chronic) the distal colon was taken for in vitro measurement of smooth muscle tension and histological assessment. Acute colitis featured injury and neutrophilic infiltration confined to the mucosa while chronic inflammation showed marked injury, lymphocytic infiltration and muscle thickening. Acute inflammation increased responses to substance P and acetylcholine but decreased responses to neurokinin A. The enhanced response to substance P was dependent on nerves, while the decreased response to neurokinin A reflected a reduction in activity at the level of the smooth muscle. In the saline group, there was evidence of cholinergic interaction with substance P, but not neurokinin A. Substance P modulation of cholinergic nerves was absent in acute inflammation. Responses to all neurotransmitters were decreased in the chronic stage. These data demonstrate progressive changes in the smooth muscle function during acute and chronic colitis that may contribute to the abnormal motility associated with inflammatory bowel disease. JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society AU - Hosseini, J M AU - Goldhill, J M AU - Bossone, C AU - Piñeiro-Carrero, V AU - Shea-Donohue, T AD - Department of Physiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4799, USA. Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 347 EP - 356 VL - 11 IS - 5 SN - 1350-1925, 1350-1925 KW - Nicotinic Antagonists KW - 0 KW - Parasympatholytics KW - Vasodilator Agents KW - Substance P KW - 33507-63-0 KW - Hexamethonium KW - 3C9PSP36Z2 KW - Tetrodotoxin KW - 4368-28-9 KW - Potassium Chloride KW - 660YQ98I10 KW - Atropine KW - 7C0697DR9I KW - Neurokinin A KW - 86933-74-6 KW - Trinitrobenzenesulfonic Acid KW - 8T3HQG2ZC4 KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Parasympatholytics -- pharmacology KW - Potassium Chloride -- pharmacology KW - Acetylcholine -- pharmacology KW - Hexamethonium -- pharmacology KW - Vasodilator Agents -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Substance P -- pharmacology KW - Neurokinin A -- pharmacology KW - Nicotinic Antagonists -- pharmacology KW - Tetrodotoxin -- pharmacology KW - Atropine -- pharmacology KW - Male KW - Muscle, Smooth -- physiology KW - Gastrointestinal Motility -- physiology KW - Muscle Contraction -- drug effects KW - Colitis -- physiopathology KW - Gastrointestinal Motility -- drug effects KW - Colitis -- chemically induced KW - Muscle Contraction -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70842895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurogastroenterology+and+motility+%3A+the+official+journal+of+the+European+Gastrointestinal+Motility+Society&rft.atitle=Progressive+alterations+in+circular+smooth+muscle+contractility+in+TNBS-induced+colitis+in+rats.&rft.au=Hosseini%2C+J+M%3BGoldhill%2C+J+M%3BBossone%2C+C%3BPi%C3%B1eiro-Carrero%2C+V%3BShea-Donohue%2C+T&rft.aulast=Hosseini&rft.aufirst=J&rft.date=1999-10-01&rft.volume=11&rft.issue=5&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Neurogastroenterology+and+motility+%3A+the+official+journal+of+the+European+Gastrointestinal+Motility+Society&rft.issn=13501925&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-10 N1 - Date created - 1999-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The modality of enterobacterial common antigen polysaccharide chain lengths is regulated by o349 of the wec gene cluster of Escherichia coli K-12. AN - 70834518; 10515954 AB - The assembly of the phosphoglyceride-linked form of enterobacterial common antigen (ECA(PG)) occurs by a mechanism that involves modulation of polysaccharide chain length. However, the genetic determinant of this modulation has not been identified. Site-directed mutagenesis of o349 of the Escherichia coli K-12 wec gene cluster revealed that this locus encodes a Wzz protein that specifically modulates the chain length of ECA(PG) polysaccharides, and we have designated this locus wzz(ECA). The Wzz(ECA)-mediated modulation of ECA(PG) polysaccharide chains is the first demonstrated example of Wzz regulation involving a polysaccharide that is not linked to the core-lipid A structure of lipopolysaccharide. JF - Journal of bacteriology AU - Barr, K AU - Klena, J AU - Rick, P D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 6564 EP - 6568 VL - 181 IS - 20 SN - 0021-9193, 0021-9193 KW - Antigens, Bacterial KW - 0 KW - Glycolipids KW - Polysaccharides, Bacterial KW - enterobacterial common antigen KW - Index Medicus KW - Polysaccharides, Bacterial -- biosynthesis KW - Restriction Mapping KW - Glycolipids -- biosynthesis KW - Polysaccharides, Bacterial -- immunology KW - Glycolipids -- immunology KW - Genes, Bacterial KW - Multigene Family KW - Enterobacteriaceae -- immunology KW - Antigens, Bacterial -- biosynthesis KW - Escherichia coli -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70834518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=The+modality+of+enterobacterial+common+antigen+polysaccharide+chain+lengths+is+regulated+by+o349+of+the+wec+gene+cluster+of+Escherichia+coli+K-12.&rft.au=Barr%2C+K%3BKlena%2C+J%3BRick%2C+P+D&rft.aulast=Barr&rft.aufirst=K&rft.date=1999-10-01&rft.volume=181&rft.issue=20&rft.spage=6564&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-08 N1 - Date created - 1999-11-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1972 Oct;6(4):533-9 [4564286] Glycobiology. 1998 Jun;8(6):557-67 [9592122] Bacteriol Rev. 1976 Sep;40(3):591-632 [62571] Eur J Biochem. 1978 May 16;86(2):361-70 [658050] Eur J Biochem. 1978 Jul 17;88(1):211-8 [352696] Curr Top Microbiol Immunol. 1979;85:99-153 [385250] J Bacteriol. 1980 Jul;143(1):529-30 [6249792] Infect Immun. 1983 May;40(2):696-700 [6404831] Carbohydr Res. 1984 Oct 1;133(1):95-104 [6498860] J Bacteriol. 1985 May;162(2):494-503 [3886625] J Bacteriol. 1985 Aug;163(2):756-62 [3894334] J Bacteriol. 1988 Jan;170(1):228-33 [3275612] J Bacteriol. 1988 Apr;170(4):1589-97 [2832370] J Bacteriol. 1989 Mar;171(3):1326-32 [2493443] J Bacteriol. 1990 Feb;172(2):1035-42 [2153653] FEMS Microbiol Rev. 1988 Sep;4(3):195-222 [3078744] J Biol Chem. 1992 Jan 15;267(2):746-53 [1730666] J Bacteriol. 1992 Jul;174(14):4736-45 [1624461] J Bacteriol. 1992 Aug;174(16):5228-36 [1379582] Science. 1992 Aug 7;257(5071):771-8 [1379743] Mol Microbiol. 1993 Mar;7(5):725-34 [7682279] J Bacteriol. 1994 Feb;176(3):733-47 [7507920] Carbohydr Res. 1994 May 20;258:223-32 [8039177] J Bacteriol. 1995 Feb;177(4):1059-68 [7532168] Trends Microbiol. 1995 May;3(5):178-85 [7542987] J Bacteriol. 1995 Oct;177(19):5539-46 [7559340] J Bacteriol. 1996 Apr;178(7):1895-902 [8606162] J Bacteriol. 1996 Apr;178(7):1903-7 [8606163] Trends Microbiol. 1996 Dec;4(12):495-503 [9004408] J Bacteriol. 1997 Mar;179(5):1482-9 [9045803] Mol Microbiol. 1997 Feb;23(4):629-38 [9157235] J Bacteriol. 1997 Apr;179(7):2421-5 [9079931] Science. 1997 Sep 5;277(5331):1453-62 [9278503] J Bacteriol. 1976 May;126(2):579-86 [57114] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of recirculating industrial air on aircraft painting operations. AN - 69269096; 10561879 AB - The 1990 Clean Air Act Amendments resulted in new environmental regulations for hazardous air pollutants. Industries such as painting facilities may have to treat large volumes of air, which increases the cost of an air control system. Recirculating a portion of the air back into the facility is an option to reduce the amount of air to be treated. The authors of this study developed a computer model written in Microsoft Excel 97 to analyze the impact of recirculation on worker safety and compliance costs. The model has a chemical database with over 1300 chemicals. The model will predict indoor air concentrations using mass balance calculations and results are compared to occupational exposure limits. A case study is performed on a C-130 aircraft painting facility at Hill Air Force Base, Utah. The model predicts strontium chromate concentrations found in primer paints will reach 1000 times the exposure limit. Strontium chromate and other solid particulates are nearly unaffected by recirculation because the air is filtered during recirculation. The next highest chemical, hexamethylene diisocyanate, increases from 2.6 to 10.5 times the exposure limit at 0 percent and 75 percent recirculation, respectively. Due to the level of respiratory protection required for the strontium chromate, workers are well protected from the modest increases in concentrations caused by recirculating 75 percent of the air. The initial cost of an air control system is $4.5 million with no recirculation and $1.8 million at 75 percent recirculation. The model is an excellent tool to evaluate air control options with a focus on worker safety. In the case study, the model highlights strontium chromate primers as good candidates for substitution. The model shows that recirculating 75 percent of the air at the Hill painting facility has a negligible impact on safety and could save $2.7 million on the initial expenses of a thermal treatment system. JF - Applied occupational and environmental hygiene AU - LaPuma, P T AU - Bolch, W E AD - Air Force Institute of Technology, Wright-Patterson Air Force Base, OH, USA. Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 682 EP - 690 VL - 14 IS - 10 SN - 1047-322X, 1047-322X KW - Air Pollutants, Occupational KW - 0 KW - Chromates KW - Cyanates KW - Isocyanates KW - 1,6-hexamethylene diisocyanate KW - 0I70A3I1UF KW - strontium chromate KW - 2W214M3GS2 KW - Strontium KW - YZS2RPE8LE KW - Index Medicus KW - Space life sciences KW - United States KW - Costs and Cost Analysis KW - Computer Simulation KW - United States Occupational Safety and Health Administration KW - Strontium -- analysis KW - Occupations KW - Cyanates -- analysis KW - Chromates -- analysis KW - Ventilation -- methods KW - Paint -- analysis KW - Aircraft KW - Ventilation -- economics KW - Air Pollutants, Occupational -- analysis KW - Paint -- adverse effects KW - Air Pollution, Indoor -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69269096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+occupational+and+environmental+hygiene&rft.atitle=The+impact+of+recirculating+industrial+air+on+aircraft+painting+operations.&rft.au=LaPuma%2C+P+T%3BBolch%2C+W+E&rft.aulast=LaPuma&rft.aufirst=P&rft.date=1999-10-01&rft.volume=14&rft.issue=10&rft.spage=682&rft.isbn=&rft.btitle=&rft.title=Applied+occupational+and+environmental+hygiene&rft.issn=1047322X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-12-02 N1 - Date created - 1999-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Appl Occup Environ Hyg. 2000 Oct;15(10):740-3 [11036724] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Simplified expressions for spatial moments of ground-water contaminant plumes AN - 52406262; 2000-002164 AB - Ground-water aquifers are an important source of water for domestic, agricultural, and industrial use, but they are often contaminated by hazardous chemicals. In this note, the writers consider the transport of a sorbing contaminant in an infinite, macroscopically homogeneous aquifer. Nonequilibrium sorption is controlled by diffusion into the grains of the porous medium. For this problem, previous work by Goltz and Roberts has presented analytical solutions for the spatial moments of the contaminant plume. The solutions of Goltz and Roberts are given in terms of infinite integrals that can be difficult to evaluate. In this note, the writers demonstrate that the zeroth spatial moment can be represented as an infinite sum rather than as an infinite integral; in most cases, the sum is more easily evaluated than the integral. Also, we show a method for simplifying the expression for the first spatial moment. The modified expression still requires the evaluation of an infinite integral, but the new integral is much better behaved than the previous expression, greatly simplifying the numerical evaluation of the first moment. JF - Journal of Hydrologic Engineering AU - Cunningham, Jeffrey A AU - Goltz, Mark N AU - Roberts, Paul V Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 377 EP - 380 PB - American Society of Civil Engineers, New York, NY VL - 4 IS - 4 SN - 1084-0699, 1084-0699 KW - solute transport KW - hazardous waste KW - sorption KW - agricultural waste KW - contaminant plumes KW - waste water KW - pollutants KW - one-dimensional models KW - pollution KW - chemical waste KW - ground water KW - aquifers KW - transport KW - industrial waste KW - waste disposal KW - water resources KW - diffusivity KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52406262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hydrologic+Engineering&rft.atitle=Simplified+expressions+for+spatial+moments+of+ground-water+contaminant+plumes&rft.au=Cunningham%2C+Jeffrey+A%3BGoltz%2C+Mark+N%3BRoberts%2C+Paul+V&rft.aulast=Cunningham&rft.aufirst=Jeffrey&rft.date=1999-10-01&rft.volume=4&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hydrologic+Engineering&rft.issn=10840699&rft_id=info:doi/ L2 - http://scitation.aip.org/heo/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 13 N1 - PubXState - NY N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - agricultural waste; aquifers; chemical waste; contaminant plumes; diffusivity; ground water; hazardous waste; industrial waste; one-dimensional models; pollutants; pollution; solute transport; sorption; transport; waste disposal; waste water; water resources ER - TY - JOUR T1 - Nitrogen dynamics in two high elevation catchments during spring snowmelt 1996, Rocky Mountains, Colorado AN - 17602113; 4680962 AB - Snowpack, soil, soil leachate, and streamwater samples were analyzed for inorganic nitrogen (N) to quantify the net effect of soil processes on N export during spring snowmelt. The two catchments used for this work, Snake River and Deer Creek, are located in Summit County, Colorado and range in elevation from 3350 to 4120 m. Atmospheric N loading to the snowpack, 88 mg N m super(-2) (=0.88 kg N ha super(-1)), was representative of low N deposition sites in the Rocky Mountains. Potentially mobile inorganic N in soil, 1252 to 1868 mg N m super(-2), was much greater than N inputs from snow. During spring snowmelt, nitrate (NO sub(3) super(-)) leachate from alpine soil, 702 mg N m super(-2), was significantly greater than from sub-alpine forest and meadow soils (p < 0.001). This pattern in soil leachate was consistent with streamwater N concentrations in Deer Creek, indicating the importance of soil processes in regulating N export from these high elevation catchments. Soils may function as sources or sinks of N during spring snowmelt; alpine soils were a significant source of N to the stream, while sub-alpine soils were possible N sinks. JF - Hydrological Processes AU - Heuer, K AU - Brooks, P D AU - Tonnessen, KA AD - National Park Service - Air Resources Division, P.O. Box 25287, Denver, CO 80225-0287, USA, Kristi_heuer@nps.gov A2 - Hardy, JP A2 - Albert, MR A2 - Marsh, P (eds) Y1 - 1999/10// PY - 1999 DA - Oct 1999 SP - 2203 EP - 2214 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 13 IS - 14-15 SN - 0885-6087, 0885-6087 KW - USA, Colorado, Rocky Mts. KW - ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Snowpack KW - Catchment area KW - USA, Snake R. KW - Cycling Nutrients KW - Snow KW - Catchment Areas KW - Forests KW - Spring KW - Surface Water KW - Freshwater KW - Mountains KW - USA, Colorado, Deer Creek KW - Nitrogen fixation KW - River water KW - Meltwater KW - Soils KW - Nitrogen cycle KW - Nitrogen KW - SW 0880:Chemical processes KW - Q2 09184:Composition of water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17602113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hydrological+Processes&rft.atitle=Nitrogen+dynamics+in+two+high+elevation+catchments+during+spring+snowmelt+1996%2C+Rocky+Mountains%2C+Colorado&rft.au=Heuer%2C+K%3BBrooks%2C+P+D%3BTonnessen%2C+KA&rft.aulast=Heuer&rft.aufirst=K&rft.date=1999-10-01&rft.volume=13&rft.issue=14-15&rft.spage=2203&rft.isbn=&rft.btitle=&rft.title=Hydrological+Processes&rft.issn=08856087&rft_id=info:doi/10.1002%2F%28SICI%291099-1085%28199910%2913%3A14%2F153.0.CO%3B2-+K LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Catchment area; River water; Nitrogen fixation; Soils; Forests; Nitrogen cycle; Spring; Snowpack; Mountains; Snow; Cycling Nutrients; Catchment Areas; Meltwater; Surface Water; Nitrogen; USA, Snake R.; USA, Colorado, Deer Creek; Freshwater DO - http://dx.doi.org/10.1002/(SICI)1099-1085(199910)13:14/15<2203::AID-HYP859>3.0.CO;2- ER - TY - JOUR T1 - Nucleosides as a carbon source in Bacillus subtilis: characterization of the drm--pupG operon AN - 17498227; 4689781 AB - In Bacillus subtilis, nucleosides are readily taken up from the growth medium and metabolized. The key enzymes in nucleoside catabolism are nucleoside phosphorylases, phosphopentomutase, and deoxyriboaldolase. The characterization of two closely linked loci, drm and pupG, which encode phosphopentomutase (Drm) and guanosine (inosine) phosphorylase (PupG), respectively, is reported here. When expressed in Escherichia coli mutant backgrounds, drm and pupG confer phosphopentomutase and purine-nucleoside phosphorylase activity. Northern blot and enzyme analyses showed that drm and pupG form a dicistronic operon. Both enzymes are induced when nucleosides are present in the growth medium. Using mutants deficient in nucleoside catabolism, it was demonstrated that the low-molecular-mass effectors of this induction most likely were deoxyribose 5-phosphate and ribose 5-phosphate. Both Drm and PupG activity levels were higher when succinate rather than glucose served as the carbon source, indicating that the expression of the operon is subject to catabolite repression. Primer extension analysis identified two transcription initiation signals upstream of drm; both were utilized in induced and non-induced cells. The nucleoside-catabolizing system in B. subtilis serves to utilize the base for nucleotide synthesis while the pentose moiety serves as the carbon source. When added alone, inosine barely supports growth of B. subtilis. This slow nucleoside catabolism contrasts with that of E. coli, which grows rapidly on a nucleoside as a carbon source. When inosine was added with succinate or deoxyribose, however, a significant increase in growth was observed in B. subtilis. The findings of this study therefore indicate that the B. subtilis system for nucleoside catabolism differs greatly from the well-studied system in E. coli. JF - Microbiology AU - Schuch, R AU - Garibian, A AU - Saxild, H H AU - Piggot, P J AU - Nygaard, P AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences Bethesda, MD 20814, USA Y1 - 1999/10// PY - 1999 DA - Oct 1999 SP - 2957 EP - 2966 VL - 145 IS - 10 SN - 1350-0872, 1350-0872 KW - drm gene KW - nucleosides KW - pupG gene KW - Microbiology Abstracts B: Bacteriology KW - Guanosine phosphorylase KW - Phosphopentomutase KW - Bacillus subtilis KW - Carbon sources KW - Operons KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17498227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology&rft.atitle=Nucleosides+as+a+carbon+source+in+Bacillus+subtilis%3A+characterization+of+the+drm--pupG+operon&rft.au=Schuch%2C+R%3BGaribian%2C+A%3BSaxild%2C+H+H%3BPiggot%2C+P+J%3BNygaard%2C+P&rft.aulast=Schuch&rft.aufirst=R&rft.date=1999-10-01&rft.volume=145&rft.issue=10&rft.spage=2957&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bacillus subtilis; Operons; Phosphopentomutase; Guanosine phosphorylase; Carbon sources ER - TY - JOUR T1 - Performance and accuracy evaluation of small satellite transmitters AN - 17491076; 4686127 AB - Recent technological advances have resulted in small (30 g) satellite platform transmitter terminals (PTTs) that can be used to track animals with masses as little as 900-1,000 g. While larger PTTs (>80 g) often yield locations accurate to within hundreds of meters, the location accuracy of smaller PTTs has not been tested. We did these tests while using the PTTs to document migration routes and nonbreeding areas of American peregrine falcons (Falco peregrinus anatum). We PTT-tagged 42 female peregrines from 2 breeding areas (upper Yukon River in eastcentral Alaska and Lake Powell on the Colorado Plateau in southern Utah and northern Arizona) late in the breeding seasons of 1993-95. Only 2 of the PTTs failed prematurely (4.7% failure rate). Active PTTs (i.e., PTTs on live birds that eventually stopped transmitting due to battery exhaustion) averaged 280 transmission hours for 1993-94 (n = 3), 380 transmission hours for 1994-95 (n = 7), and 430 transmission hours for 1995-96 (n = 15). Using an estimate of maximum ground speed of peregrines (104 km/hr) based on empirical observations and aerodynamic calculations, we determined that 4.48% of all locations provided to us by Argos (n = 2,323) were biologically implausible. We also received many poor-quality locations (68% of records were in Argos location classes 0, A, and B) typical of small, relatively underpowered PTTs. To estimate location accuracy of these poor-quality locations, we compared Argos-estimated locations with known locations of 11 rock doves (Columba livia) tagged with PTTs. The location types with the highest precision averaged 4 km from the true location, while the location types with the lowest precision averaged 35 km from the true location. These results indicate the PTT locations were sufficient to document animal movements over broad spatial scales such as identifying migration routes and nonbreeding areas of birds. This technology is more efficient and less biased than the current approaches used to obtain this information (mark-resighting of banded animals or standard radiotelemetry techniques). However, the PTTs currently available are not suitable when position accuracy <35 km is needed. JF - Journal of Wildlife Management AU - Britten, M W AU - Kennedy, P L AU - Ambrose, S AD - National Park Service, 12795 West Alameda Parkway, Lakewood, CO 80228, USA, mike_britten@nps.gov Y1 - 1999/10// PY - 1999 DA - Oct 1999 SP - 1349 EP - 1358 VL - 63 IS - 4 SN - 0022-541X, 0022-541X KW - American peregrine falcon KW - Canada KW - USA KW - Ecology Abstracts KW - Falco peregrinus anatum KW - Migration KW - Satellites KW - Tracking KW - D 04002:Surveying and remote sensing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17491076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Wildlife+Management&rft.atitle=Performance+and+accuracy+evaluation+of+small+satellite+transmitters&rft.au=Britten%2C+M+W%3BKennedy%2C+P+L%3BAmbrose%2C+S&rft.aulast=Britten&rft.aufirst=M&rft.date=1999-10-01&rft.volume=63&rft.issue=4&rft.spage=1349&rft.isbn=&rft.btitle=&rft.title=Journal+of+Wildlife+Management&rft.issn=0022541X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Falco peregrinus anatum; Satellites; Tracking; Migration ER - TY - JOUR T1 - Effect of Zebra Mussels, Dreissena polymorpha, on Macroinvertebrates in a Lake-outlet Stream AN - 17404760; 4632413 AB - Zebra mussels, Dreissena polymorpha, increase macroinvertebrate abundance on hard substrata in lakes and large rivers because they enhance surface area, substratum heterogeneity and the accumulation of benthic organic matter (BOM). We tested the hypothesis that zebra mussel colonization of hard substrata in a lake-outlet stream would similarly increase macroinvertebrate abundance. Zebra mussels were attached to artificial rocks (0.05 m super(2)) in a crossed factorial design with two states of mussels (live or dead) and three densities [low (200/m super(2)), medium (500/m super(2)) or high (1000/m super(2))] plus a noncrossed control (no attached mussels). Rocks were placed in an erosional zone of a lake-outlet stream in southwestern Michigan that contained low densities of zebra mussels. After 28 d total macroinvertebrate abundance was significantly higher on rocks with high densities of zebra mussels, but live or dead treatment had no effect on macroinvertebrate abundance. Family richness differed significantly among density treatments (high = medium > low = control), but Simpson's diversity index did not differ among treatments. We conclude that changes in macroinvertebrate community structure probably were related to the increased substrate complexity provided by zebra mussels. JF - American Midland Naturalist AU - Horvath, T G AU - Martin, K M AU - Lamberti, G A AD - Lake Michigan Ecological Research Station, 1100 N. Mineral Springs Rd., Porter, MI 46304, USA, Tom_horvath@nps.gov Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 340 EP - 347 VL - 142 IS - 2 SN - 0003-0031, 0003-0031 KW - USA, Michigan KW - Zebra mussel KW - Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Entomology Abstracts; Ecology Abstracts KW - Abundance KW - Population density KW - Invertebrates KW - Freshwater KW - Habitat selection KW - Colonization KW - Lakes KW - Organic Matter KW - Substrate preferences KW - Exotic Species KW - Substrates KW - Invertebrata KW - Dreissena polymorpha KW - Rivers KW - Substrata KW - Organic matter KW - Environmental impact KW - Zebra Mussels KW - Species diversity KW - Zoobenthos KW - Introduced species KW - Q1 08483:Species interactions: general KW - D 04310:Freshwater KW - SW 0850:Lakes KW - Z 05210:Aquatic entomology KW - Q5 08521:Mechanical and natural changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17404760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Midland+Naturalist&rft.atitle=Effect+of+Zebra+Mussels%2C+Dreissena+polymorpha%2C+on+Macroinvertebrates+in+a+Lake-outlet+Stream&rft.au=Horvath%2C+T+G%3BMartin%2C+K+M%3BLamberti%2C+G+A&rft.aulast=Horvath&rft.aufirst=T&rft.date=1999-10-01&rft.volume=142&rft.issue=2&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=American+Midland+Naturalist&rft.issn=00030031&rft_id=info:doi/10.1043%2F0003-0031%281999%29142%280340%3AEOZMDP%292.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Rivers; Substrata; Colonization; Substrate preferences; Organic matter; Abundance; Environmental impact; Population density; Introduced species; Zoobenthos; Habitat selection; Species diversity; Lakes; Organic Matter; Exotic Species; Substrates; Invertebrates; Zebra Mussels; Invertebrata; Dreissena polymorpha; Freshwater DO - http://dx.doi.org/10.1043/0003-0031(1999)142(0340:EOZMDP)2.0.CO;2 ER - TY - JOUR T1 - Bacterial interference in upper respiratory tract infections AN - 17385306; 4617787 AB - Bacterial antagonism and synergism help maintain the balance of the normal endogenous flora. The production of bacteriocins by some micro-organisms is one of the important mechanisms of interference. The role of bacterial interference in upper respiratory tract infections and the effect of this phenomenon on the eradication of infection is detailed. The infections discussed include pharyngotonsillitis, otitis media and sinusitis. The effects of antimicrobial agents on organisms causing these conditions and interactions between pathogens and other bacteria are also described. JF - Reviews in Medical Microbiology AU - Brook, I AD - PO Box 70412, Chevy Chase MD 20813-0412, USA, brook@mx.afrri.usuhs.mil Y1 - 1999/10// PY - 1999 DA - Oct 1999 SP - 225 EP - 233 VL - 10 IS - 4 SN - 0954-139X, 0954-139X KW - antagonists KW - infectious diseases KW - bacteria KW - Microbiology Abstracts B: Bacteriology KW - Bacteriocins KW - Pharyngotonsillitis KW - Otitis media KW - Reviews KW - Microflora KW - Sinusitis KW - Antimicrobial agents KW - Respiratory tract KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17385306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+in+Medical+Microbiology&rft.atitle=Bacterial+interference+in+upper+respiratory+tract+infections&rft.au=Brook%2C+I&rft.aulast=Brook&rft.aufirst=I&rft.date=1999-10-01&rft.volume=10&rft.issue=4&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Reviews+in+Medical+Microbiology&rft.issn=0954139X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Reviews; Respiratory tract; Microflora; Pharyngotonsillitis; Otitis media; Sinusitis; Antimicrobial agents; Bacteriocins ER - TY - JOUR T1 - Painful tonic/dystonic spasms in Sjogren's syndrome. AN - 85320987; pmid-10495053 AB - Three patients with Sjogren's syndrome are presented in whom frequent tonic/dystonic spasms of the limbs developed during the course of the illness. These patients' clinical findings suggested spinal cord involvement, a localization that was confirmed by magnetic resonance imaging in two patients. In one patient the painful movements responded to treatment with phenytoin and in one other to baclofen. Sjogren's syndrome should be considered in the differential diagnosis of conditions that produce tonic/dystonic limb spasms. JF - Movement disorders : official journal of the Movement Disorder Society AU - Jabbari, B AU - Salardini, A AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1999/09// PY - 1999 DA - September 1999 SP - 860 EP - 864 VL - 14 IS - 5 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Magnetic Resonance Imaging KW - Prednisone -- therapeutic use KW - Humans KW - Anti-Inflammatory Agents -- therapeutic use KW - Pain Measurement KW - Pain -- diagnosis KW - Arm KW - Antibodies, Antinuclear -- immunology KW - Pain -- etiology KW - Adult KW - Middle Aged KW - Male KW - Female KW - Dystonic Disorders -- diagnosis KW - Muscular Diseases -- diagnosis KW - Muscular Diseases -- complications KW - Sjogren's Syndrome -- drug therapy KW - Epilepsy, Generalized -- complications KW - Dystonic Disorders -- complications KW - Spinal Cord Ischemia -- pathology KW - Spasm -- diagnosis KW - Spasm -- complications KW - Sjogren's Syndrome -- diagnosis KW - Sjogren's Syndrome -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85320987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Painful+tonic%2Fdystonic+spasms+in+Sjogren%27s+syndrome.&rft.au=Jabbari%2C+B%3BSalardini%2C+A&rft.aulast=Jabbari&rft.aufirst=B&rft.date=1999-09-01&rft.volume=14&rft.issue=5&rft.spage=860&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Carbon dioxide exchange via the mucosa in healthy middle ear. AN - 85305618; pmid-10488982 AB - BACKGROUND: Recent studies have shown that gas exchange via the middle ear mucosa, which is performed between the middle ear cleft and capillaries in the submucosal connective tissue, has an essential role in ventilation and pressure regulation in the middle ear cleft. We speculated that gas exchange via the mucosa is induced by the gas diffusion caused by the partial pressure gradient of gas between the middle ear cleft and submucosal capillaries. OBJECTIVE: To evaluate the capacity of the gas exchange via the mucosa in the healthy middle ear of humans by examining the effect of the respiratory mode on middle ear pressure. SUBJECTS AND METHODS: We selected 13 volunteers ranging in age from 25 to 44 years with healthy ear drums and type A tympanograms. Middle ear pressure was measured in 1 ear of each subject every 2 minutes using tympanometry while the respiratory mode was altered, with the subject in the supine position. RESULTS: The partial pressure of carbon dioxide in the venous blood (PvCO2) and middle ear pressure were decreased by hyperventilation and increased by hypoventilation. The partial pressure of oxygen in the venous blood showed little change. CONCLUSIONS: Carbon dioxide diffused into the blood from the middle ear cleft in accord with the partial pressure gradient when the PvCO2 was reduced by hyperventilation, resulting in a decrease of middle ear pressure, whereas CO2 diffused into the middle ear cleft when the PvCO2 was elevated by hypoventilation, resulting in an increase of middle ear pressure. These findings suggest that a bidirectional CO2 exchange via the middle ear mucosa functions in the normal human middle ear. JF - Archives of otolaryngology--head & neck surgery AU - Ikarashi, F AU - Takahashi, S AU - Yamamoto, Y AD - Department of Otolaryngology, The Nippon Dental University School of Dentistry at Niigata, Japan. jibika@ngt.ndu.ac.jp Y1 - 1999/09// PY - 1999 DA - September 1999 SP - 975 EP - 978 VL - 125 IS - 9 SN - 0886-4470, 0886-4470 KW - Abridged Index Medicus; Index Medicus KW - National Library of Medicine KW - Hyperventilation -- metabolism KW - Mastoid -- metabolism KW - Reference Values KW - Humans KW - Adult KW - Mucous Membrane -- metabolism KW - Hypoventilation -- metabolism KW - Diffusion KW - Atmospheric Pressure KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Ear, Middle -- metabolism KW - Carbon Monoxide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85305618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+otolaryngology--head+%26+neck+surgery&rft.atitle=Carbon+dioxide+exchange+via+the+mucosa+in+healthy+middle+ear.&rft.au=Ikarashi%2C+F%3BTakahashi%2C+S%3BYamamoto%2C+Y&rft.aulast=Ikarashi&rft.aufirst=F&rft.date=1999-09-01&rft.volume=125&rft.issue=9&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=Archives+of+otolaryngology--head+%26+neck+surgery&rft.issn=08864470&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Trends in child maltreatment in the US Army, 1975-1997 AN - 18009556; 4700383 AB - Objective: To examine trends by year in reports of victims of child maltreatment in the US Army Central Registry (ACR) during the period 1975-97. We report the rates/1,000 children of Army families of initial substantiated cases from 1988-97 and the number of cases of maltreatment as a percentage of total victims for each year from 1975-97. Army data are compared to published reports from military service child abuse registries. Methods: Numbers of cases of child maltreatment for each year were obtained from the ACR for major, minor, and total physical abuse, sexual abuse, emotional abuse, and neglect. Population figures for numbers of children were obtained from the Defense Manpower Data Center. Results: The rates/1,000 for neglect have decreased by 24% from 1991-97, although the decrease has not been steady. The rates/1,000 of minor physical abuse declined 28% from 1993-97. The rates/1,000 of major physical abuse were basically unchanged from 1988-96, although the highest rate was recorded in 1997. The rates/1,000 of sexual abuse were also basically unchanged with the exception of increases in 1992-94 after which time the rates/1,000 returned to the pre-1992 levels. The rates/1,000 of emotional abuse cases more than doubled from 1988-97. Conclusions: While minor physical abuse and neglect have shown decreases over the past decade, major physical abuse has remained virtually unchanged and sexual and emotional abuse have shown fluctuations. All these forms of maltreatment are challenges to the Army Family Advocacy Program. JF - Child Abuse and Neglect AU - McCarroll, JE AU - Newby, J H AU - Thayer, LE AU - Ursano, R J AU - Norwood, A E AU - Fullerton, C S AD - Family Violence and Trauma Project, Henry M. Jackson Foundation for the Advancement of Military Medicine, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA Y1 - 1999/09// PY - 1999 DA - Sep 1999 SP - 855 EP - 861 VL - 23 IS - 9 SN - 0145-2134, 0145-2134 KW - child abuse KW - parent-offspring interactions KW - working conditions KW - Risk Abstracts; Health & Safety Science Abstracts KW - USA KW - Military KW - Occupational health KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18009556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Abuse+and+Neglect&rft.atitle=Trends+in+child+maltreatment+in+the+US+Army%2C+1975-1997&rft.au=McCarroll%2C+JE%3BNewby%2C+J+H%3BThayer%2C+LE%3BUrsano%2C+R+J%3BNorwood%2C+A+E%3BFullerton%2C+C+S&rft.aulast=McCarroll&rft.aufirst=JE&rft.date=1999-09-01&rft.volume=23&rft.issue=9&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=Child+Abuse+and+Neglect&rft.issn=01452134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - USA; Military; Occupational health ER - TY - JOUR T1 - Managing alcohol-related problems in the primary care setting. AN - 70017296; 10479108 AB - Although alcohol-related problems are a significant source of morbidity and mortality in the United States, denial and resistance to treatment by patients and their families make detection challenging. Primary care providers may find it difficult to confront the patient who drinks excessively; however, early intervention can lower morbidity and prevent progressive damage to family and social relationships. Routine alcohol screening of all patients may assist the primary care provider in effectively identifying and treating alcohol abuse. Although abstinence is the primary goal for patients with alcohol-related problems, decreasing intake is also beneficial and may be accomplished with brief primary care interventions. The management of outpatient alcohol detoxification is increasingly provided by primary care providers in managed care environments, but requires careful assessment of the patient's support system, close provider supervision, and appropriate pharmacologic support. JF - The Nurse practitioner AU - Martin, A C AU - Schaffer, S D AU - Campbell, R AD - Uniformed Services University of the Health Sciences, Graduate School of Nursing, USA. Y1 - 1999/08// PY - 1999 DA - August 1999 SP - 14 EP - 8, 21, 25-6, 28, 38-9; quiz VL - 24 IS - 8 SN - 0361-1817, 0361-1817 KW - Index Medicus KW - Nursing KW - Managed Care Programs KW - Ambulatory Care -- methods KW - Attitude to Health KW - Humans KW - Nurse Practitioners KW - Social Support KW - Middle Aged KW - Aftercare -- methods KW - United States -- epidemiology KW - Mass Screening -- methods KW - Nursing Assessment -- methods KW - Female KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Primary Health Care -- methods KW - Alcoholism -- psychology KW - Alcoholism -- prevention & control KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70017296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nurse+practitioner&rft.atitle=Managing+alcohol-related+problems+in+the+primary+care+setting.&rft.au=Martin%2C+A+C%3BSchaffer%2C+S+D%3BCampbell%2C+R&rft.aulast=Martin&rft.aufirst=A&rft.date=1999-08-01&rft.volume=24&rft.issue=8&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=The+Nurse+practitioner&rft.issn=03611817&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-10-07 N1 - Date created - 1999-10-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nurse Pract. 1999 Nov;24(11):15 [10618810] Nurse Pract. 2000 Feb;25(2):11-2, 14 [10703021] Erratum In: Nurse Pract 1999 Oct;24(10):18 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acceleration of viral replication and up-regulation of cytokine levels by antimalarials: implications in malaria-endemic areas. AN - 69996294; 10463664 AB - Antimalarial drugs are widely used in malaria endemic areas, both for chemoprophylaxis and also empirically to treat patients presenting with fever. Previously, we have reported that chloroquine enhances the severity of Semliki forest virus (SFV) and encephalomyocarditis virus infection. The studies presented herein show that a broad spectrum of antimalarial drugs augmented the replication of SFV in mice, concomitant with greater tissue damage and up-regulation of mRNA levels of various inflammatory cytokine genes, including interleukin-1 receptor antagonist (IL-1Ra), II-1alpha, IL-1beta, IL-6, IL-12p40, and interferon-gamma inducing factor. Furthermore, chloroquine enhances IL-1Ra production in RAW cells in vitro. Since IL-1Ra is known to be up-regulated in a number of viral infections, we propose that a further enhancement of its expression by antimalarials may be responsible for the increased severity of viral infection in our studies. Thus, the widespread use of antimalarials in malaria-endemic areas may predispose the population to viral infections. Further studies are in progress to delineate mechanism(s) involved in cytokine up-regulation and acceleration of viral replication. JF - The American journal of tropical medicine and hygiene AU - Seth, P AU - Mani, H AU - Singh, A K AU - Banaudha, K K AU - Madhavan, S AU - Sidhu, G S AU - Gaddipati, J P AU - Vogel, S N AU - Maheshwari, R K AD - Center for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1999/08// PY - 1999 DA - August 1999 SP - 180 EP - 186 VL - 61 IS - 2 SN - 0002-9637, 0002-9637 KW - Antimalarials KW - 0 KW - Interleukins KW - RNA, Messenger KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Interleukins -- biosynthesis KW - RNA, Messenger -- drug effects KW - Lethal Dose 50 KW - Mice KW - Up-Regulation KW - RNA, Messenger -- genetics KW - Mice, Inbred BALB C KW - Male KW - Interleukins -- genetics KW - Female KW - Antimalarials -- pharmacology KW - Semliki forest virus -- drug effects KW - Virus Replication -- drug effects KW - Alphavirus Infections -- virology KW - Alphavirus Infections -- pathology KW - Semliki forest virus -- physiology KW - Antimalarials -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69996294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+tropical+medicine+and+hygiene&rft.atitle=Acceleration+of+viral+replication+and+up-regulation+of+cytokine+levels+by+antimalarials%3A+implications+in+malaria-endemic+areas.&rft.au=Seth%2C+P%3BMani%2C+H%3BSingh%2C+A+K%3BBanaudha%2C+K+K%3BMadhavan%2C+S%3BSidhu%2C+G+S%3BGaddipati%2C+J+P%3BVogel%2C+S+N%3BMaheshwari%2C+R+K&rft.aulast=Seth&rft.aufirst=P&rft.date=1999-08-01&rft.volume=61&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+tropical+medicine+and+hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-09-21 N1 - Date created - 1999-09-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Trop Med Hyg. 2000 Jan;62(1):1-3 [10761717] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Astrocytes as targets for Venezuelan equine encephalitis virus infection. AN - 69996255; 10463856 AB - Venezuelan equine encephalitis virus (VEE) produces an acute infection in humans and induces a well-characterized cytopathic effect in neurons of the central nervous system (CNS). However, little is known about the role of glial cells in response to VEE infection of the CNS. Our results demonstrate that VEE is capable of a productive infection in primary astrocyte cultures and that this infection is cytotoxic. Further, there were significant differences in the growth kinetics comparing virulent and attenuated strains of VEE. Additionally, VEE infection of astrocyte cultures induced gene expression of two neuro-immune modulators, tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS). Assays for TNF-alpha protein and nitric oxide (NO) demonstrated high levels of TNF-alpha protein and low levels of NO in response to VEE infection of astrocytes. These observations suggest an important role of astrocytes in this virus-induced encephalitis, and that interactions between astrocytes, other glial cells, and neurons may be important in VEE pathogenesis. Such interactions, which could impact neuronal survival, may include loss of functional changes in astrocytes or, alternatively, their production of neurotoxic molecules. JF - Journal of neurovirology AU - Schoneboom, B A AU - Fultz, M J AU - Miller, T H AU - McKinney, L C AU - Grieder, F B AD - Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Y1 - 1999/08// PY - 1999 DA - August 1999 SP - 342 EP - 354 VL - 5 IS - 4 SN - 1355-0284, 1355-0284 KW - Tumor Necrosis Factor-alpha KW - 0 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type II KW - Nos2 protein, rat KW - Index Medicus KW - Virus Replication KW - Virulence KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Encephalomyelitis, Venezuelan Equine -- pathology KW - Cells, Cultured KW - Tumor Necrosis Factor-alpha -- analysis KW - Tumor Necrosis Factor-alpha -- metabolism KW - Nitric Oxide Synthase -- metabolism KW - Nitric Oxide Synthase -- analysis KW - Astrocytes -- virology KW - Encephalitis Virus, Venezuelan Equine -- physiology KW - Encephalitis Virus, Venezuelan Equine -- pathogenicity KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69996255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurovirology&rft.atitle=Astrocytes+as+targets+for+Venezuelan+equine+encephalitis+virus+infection.&rft.au=Schoneboom%2C+B+A%3BFultz%2C+M+J%3BMiller%2C+T+H%3BMcKinney%2C+L+C%3BGrieder%2C+F+B&rft.aulast=Schoneboom&rft.aufirst=B&rft.date=1999-08-01&rft.volume=5&rft.issue=4&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurovirology&rft.issn=13550284&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-10-07 N1 - Date created - 1999-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asbestos exposure upregulates the adhesion of pleural leukocytes to pleural mesothelial cells via VCAM-1. AN - 69965718; 10444523 AB - This study was designed to assess the effects of in vitro and in vivo asbestos exposure on the adhesion of rat pleural leukocytes (RPLs) labeled with the fluorochrome calcein AM to rat pleural mesothelial cells (RPMCs). Exposure of RPMCs for 24 h to either crocidolite or chrysotile fibers (1.25-10 microgram/cm(2)) increased the adhesion of RPLs to RPMCs in a dose-dependent fashion, an effect that was potentiated by interleukin-1beta. These findings were not observed with nonfibrogenic carbonyl iron particles. Crocidolite and chrysotile plus interleukin-1beta also upregulated vascular cell adhesion molecule-1 mRNA and protein expression in RPMCs, and the binding of RPL to asbestos-treated RPMCs was abrogated by anti-vascular cell adhesion molecule-1 antibody. PRLs exposed by intermittent inhalation to crocidolite for 2 wk manifested significantly greater binding to RPMCs than did RPLs from sham-exposed animals. The ability of asbestos fibers to upregulate RPL adhesion to RPMCs may play a role in the induction and/or potentiation of asbestos-induced pleural injury. JF - The American journal of physiology AU - Choe, N AU - Zhang, J AU - Iwagaki, A AU - Tanaka, S AU - Hemenway, D R AU - Kagan, E AD - Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1999/08// PY - 1999 DA - August 1999 SP - L292 EP - L300 VL - 277 IS - 2 Pt 1 SN - 0002-9513, 0002-9513 KW - Vascular Cell Adhesion Molecule-1 KW - 0 KW - Asbestos, Crocidolite KW - 12001-28-4 KW - Intercellular Adhesion Molecule-1 KW - 126547-89-5 KW - Asbestos KW - 1332-21-4 KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Rats KW - Intercellular Adhesion Molecule-1 -- physiology KW - Asbestos, Crocidolite -- pharmacology KW - Animals KW - Rats, Inbred F344 KW - Epithelial Cells -- physiology KW - Cells, Cultured KW - Nitric Oxide -- physiology KW - Nitric Oxide -- biosynthesis KW - Cell Adhesion -- drug effects KW - Administration, Inhalation KW - Male KW - Leukocytes -- physiology KW - Asbestos -- pharmacology KW - Vascular Cell Adhesion Molecule-1 -- physiology KW - Pleura -- cytology KW - Pleura -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69965718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Asbestos+exposure+upregulates+the+adhesion+of+pleural+leukocytes+to+pleural+mesothelial+cells+via+VCAM-1.&rft.au=Choe%2C+N%3BZhang%2C+J%3BIwagaki%2C+A%3BTanaka%2C+S%3BHemenway%2C+D+R%3BKagan%2C+E&rft.aulast=Choe&rft.aufirst=N&rft.date=1999-08-01&rft.volume=277&rft.issue=2+Pt+1&rft.spage=L292&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-09-23 N1 - Date created - 1999-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates. AN - 69886788; 10400757 AB - CXCR4 is a chemokine receptor and a coreceptor for T-cell-line-tropic (X4) and dual-tropic (R5X4) human immunodeficiency virus type 1 (HIV-1) isolates. Cells coexpressing CXCR4 and CD4 will fuse with appropriate HIV-1 envelope glycoprotein (Env)-expressing cells. The delineation of the critical regions involved in the interactions within the Env-CD4-coreceptor complex are presently under intensive investigation, and the use of chimeras of coreceptor molecules has provided valuable information. To define these regions in greater detail, we have employed a strategy involving alanine-scanning mutagenesis of the extracellular domains of CXCR4 coupled with a highly sensitive reporter gene assay for HIV-1 Env-mediated membrane fusion. Using a panel of 41 different CXCR4 mutants, we have identified several charged residues that appear important for coreceptor activity for X4 Envs; the mutations E15A (in which the glutamic acid residue at position 15 is replaced by alanine) and E32A in the N terminus, D97A in extracellular loop 1 (ecl-1), and R188A in ecl-2 impaired coreceptor activity for X4 and R5X4 Envs. In addition, substitution of alanine for any of the four extracellular cysteines alone resulted in conformational changes of various degrees, while mutants with paired cysteine deletions partially retained their structure. Our data support the notion that all four cysteines are involved in disulfide bond formation. We have also identified substitutions which greatly enhance or convert CXCR4's coreceptor activity to support R5 Env-mediated fusion (N11A, R30A, D187A, and D193A), and together our data suggest the presence of conserved extracellular elements, common to both CXCR4 and CCR5, involved in their coreceptor activities. These data will help us to better detail the CXCR4 structural requirements exhibited by different HIV-1 strains and will direct further mutagenesis efforts aimed at better defining the domains in CXCR4 involved in the HIV-1 Env-mediated fusion process. JF - Journal of virology AU - Chabot, D J AU - Zhang, P F AU - Quinnan, G V AU - Broder, C C AD - Departments of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1999/08// PY - 1999 DA - August 1999 SP - 6598 EP - 6609 VL - 73 IS - 8 SN - 0022-538X, 0022-538X KW - Antigens, CD4 KW - 0 KW - HIV Envelope Protein gp160 KW - Receptors, CXCR4 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - AIDS/HIV KW - 3T3 Cells KW - Animals KW - HeLa Cells KW - Humans KW - Gene Expression KW - Rabbits KW - Amino Acid Sequence KW - Mice KW - Cysteine -- physiology KW - Antigens, CD4 -- metabolism KW - Binding Sites KW - Tumor Cells, Cultured KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Cell Line KW - Mutagenesis, Site-Directed KW - HIV-1 -- metabolism KW - Membrane Fusion KW - HIV-1 -- isolation & purification KW - HIV Envelope Protein gp160 -- genetics KW - HIV Envelope Protein gp160 -- metabolism KW - Receptors, CXCR4 -- metabolism KW - Receptors, CXCR4 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69886788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Mutagenesis+of+CXCR4+identifies+important+domains+for+human+immunodeficiency+virus+type+1+X4+isolate+envelope-mediated+membrane+fusion+and+virus+entry+and+reveals+cryptic+coreceptor+activity+for+R5+isolates.&rft.au=Chabot%2C+D+J%3BZhang%2C+P+F%3BQuinnan%2C+G+V%3BBroder%2C+C+C&rft.aulast=Chabot&rft.aufirst=D&rft.date=1999-08-01&rft.volume=73&rft.issue=8&rft.spage=6598&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-08-24 N1 - Date created - 1999-08-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1986 Aug;59(2):284-91 [3016298] J Virol. 1996 Aug;70(8):5487-94 [8764060] J Virol. 1990 Sep;64(9):4390-8 [2384920] J Virol. 1990 Nov;64(11):5270-6 [2214018] Nature. 1990 Nov 1;348(6296):69-73 [2172833] Biochemistry. 1991 Jun 4;30(22):5329-34 [2036400] Science. 1991 Jul 5;253(5015):71-4 [1905842] Science. 1996 Oct 25;274(5287):602-5 [8849450] Cell. 1996 Nov 1;87(3):437-46 [8898197] Nat Med. 1996 Nov;2(11):1174-8 [8898734] Nature. 1996 Nov 14;384(6605):179-83 [8906795] Nature. 1996 Nov 14;384(6605):184-7 [8906796] Science. 1996 Dec 13;274(5294):1924-6 [8943208] Pathobiology. 1996;64(4):171-9 [9031325] J Biol Chem. 1997 Mar 14;272(11):6854-7 [9054370] Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4005-10 [9108095] Virology. 1997 Apr 28;231(1):105-11 [9143308] J Virol. 1997 Jun;71(6):4744-51 [9151868] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6426-31 [9177234] EMBO J. 1997 May 15;16(10):2599-609 [9184207] J Virol. 1997 Jul;71(7):5003-11 [9188565] J Leukoc Biol. 1997 Jul;62(1):20-9 [9225988] J Virol. 1997 Sep;71(9):7136-9 [9261451] Curr Opin Immunol. 1997 Aug;9(4):551-62 [9287172] J Immunol. 1997 Sep 15;159(6):3000-8 [9300725] J Exp Med. 1997 Oct 20;186(8):1373-81 [9334377] J Virol. 1998 Jan;72(1):772-7 [9420285] Nature. 1998 Jan 15;391(6664):240 [9440686] J Virol. 1998 Feb;72(2):1160-4 [9445013] J Cell Biol. 1998 Jan 26;140(2):315-23 [9442107] J Virol. 1998 Apr;72(4):3464-8 [9525683] J Virol. 1998 Jun;72(6):4633-42 [9573226] J Biol Chem. 1998 Jun 12;273(24):15007-15 [9614108] AIDS Res Hum Retroviruses. 1998 Jul 20;14(11):939-49 [9686640] Virology. 1998 Sep 1;248(2):357-71 [9721244] J Immunol. 1998 Sep 1;161(5):2084-8 [9725197] J Virol. 1998 Oct;72(10):8453-7 [9733901] J Clin Invest. 1998 Oct 15;102(8):1540-50 [9788967] J Membr Biol. 1998 Nov 15;166(2):75-90 [9841733] Virology. 1999 Jun 20;259(1):1-6 [10364484] Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7496-501 [10377443] J Virol. 1992 May;66(5):2934-42 [1560532] J Virol. 1992 May;66(5):3183-7 [1560543] J Virol. 1992 Nov;66(11):6777-80 [1404617] J Virol. 1992 Dec;66(12):7517-21 [1433527] Virology. 1993 Mar;193(1):483-91 [8438583] J Virol. 1993 Oct;67(10):5939-47 [7690415] J Virol. 1994 Sep;68(9):5411-22 [8057423] Annu Rev Biochem. 1994;63:101-32 [7979235] Virology. 1995 Feb 1;206(2):935-44 [7531918] FASEB J. 1995 Jun;9(9):745-54 [7601339] Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):9004-8 [7568061] Science. 1996 May 10;272(5263):872-7 [8629022] Nat Med. 1996 Jun;2(6):640-1 [8640552] AIDS Res Hum Retroviruses. 1987 Spring;3(1):57-69 [3040055] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intercultural Network Theory: A Cross-Paradigmatic Approach to Acculturation AN - 61497202; 200013449 AB - Outlines three common research paradigms employed in intercultural relations & offers the social network perspective as a cross-paradigmatic research & theorizing approach. Described are the conceptual history & relevant properties of social networks for intercultural research as part of the foundation for a theory of intercultural social networks addressing the relational quality of intercultural interaction & acknowledging the stability of structural phenomena. Seven assumptions & seven propositions are proposed to launch a dynamic theory of intercultural social networks. It is concluded that a sociostructural approach to acculturation, & to intercultural relations in general, can reconcile situated emergent phenomena with reliable present phenomena, thus increasing understanding of such relations. 100 References. Adapted from the source document. JF - International Journal of Intercultural Relations AU - Smith, L Ripley AD - Dept Communication Studies, Northwestern Coll, Saint Paul, MN lrs@nwc.edu Y1 - 1999/08// PY - 1999 DA - August 1999 SP - 629 EP - 658 VL - 23 IS - 4 SN - 0147-1767, 0147-1767 KW - Acculturation KW - Network Analysis KW - Social Science Research KW - Intergroup Relations KW - Social Networks KW - Intercultural Communication KW - article KW - 0665: complex organization; social network analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61497202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Intercultural+Relations&rft.atitle=Intercultural+Network+Theory%3A+A+Cross-Paradigmatic+Approach+to+Acculturation&rft.au=Smith%2C+L+Ripley&rft.aulast=Smith&rft.aufirst=L&rft.date=1999-08-01&rft.volume=23&rft.issue=4&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Intercultural+Relations&rft.issn=01471767&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IRELDR N1 - SubjectsTermNotLitGenreText - Intercultural Communication; Social Networks; Social Science Research; Network Analysis; Intergroup Relations; Acculturation ER - TY - JOUR T1 - Impact of mesoscale ocean currents on sea ice in high-resolution Arctic ice and ocean simulations AN - 17376488; 4605125 AB - A high-resolution sea ice model is designed for simulating the Arctic. The grid resolution is similar to 18 km, and the domain contains the main Arctic Ocean, Nordic Seas, Canadian Archipelago, and the subpolar North Atlantic. The model is based on a widely used dynamic and thermodynamic model with more efficient numerics. The oceanic forcing is from an Arctic Ocean model with the same horizontal resolution as the ice model and 30 levels. The atmospheric forcing is from 3-day average 1990-1994 European Centre for Medium-Range Weather Forecasts operational data. Results from the ice model are compared against satellite passive-microwave observations and drifting buoys. The model realistically simulates ice tongues and eddies in the Greenland Sea. The mesoscale ocean eddies along the East Greenland Current (EGC) are demonstrated to be responsible for the presence of ice eddies and tongues out of the Greenland Sea ice edge. Large shear and divergence associated with the mesoscale ice eddies and strong ice drift, such as the one above the EGC, result in thinner and less compact ice. The mesoscale ocean eddies along the Alaskan Chukchi shelf break, the Northwind Ridge, and the Alpha-Mendeleyev Ridge are major contributors to mesoscale reduction of ice concentration, in addition to atmospheric storms which usually lead to a broad-scale reduction of ice concentration. The existence of mesoscale ocean eddies greatly increases nonuniformity of ice motion, which means stronger ice deformation and more open water. An eddy-resolving coupled ice-ocean model is highly recommended to adequately simulate the small but important percentage of open water in the Arctic pack ice, which can significantly change the heat fluxes from ocean to atmosphere and affect the global climate. JF - Journal of Geophysical Research. C. Oceans AU - Zhang, Y AU - Maslowski, W AU - Semtner, A J AD - Naval Postgraduate School, Monterey, California, USA Y1 - 1999/08// PY - 1999 DA - Aug 1999 SP - 18 EP - 18,429 VL - 104 IS - C8 SN - 0148-0227, 0148-0227 KW - Water Resources Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Marine KW - PN, Arctic Ocean KW - Ocean-ice-atmosphere system KW - Ocean Circulation KW - Thermodynamics KW - Water Currents KW - Ocean circulation KW - Mesoscale features KW - Ocean currents KW - Sea ice KW - Sea Ice KW - Ice drift KW - Deformation KW - Q2 09150:Ice KW - SW 0820:Snow, ice and frost KW - O 2020:Hydrodynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17376488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research.+C.+Oceans&rft.atitle=Impact+of+mesoscale+ocean+currents+on+sea+ice+in+high-resolution+Arctic+ice+and+ocean+simulations&rft.au=Zhang%2C+Y%3BMaslowski%2C+W%3BSemtner%2C+A+J&rft.aulast=Zhang&rft.aufirst=Y&rft.date=1999-08-01&rft.volume=104&rft.issue=C8&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research.+C.+Oceans&rft.issn=01480227&rft_id=info:doi/10.1029%2F1998JD100025 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Ocean currents; Ocean-ice-atmosphere system; Sea ice; Ice drift; Ocean circulation; Mesoscale features; Ocean Circulation; Thermodynamics; Water Currents; Sea Ice; Deformation; PN, Arctic Ocean; Marine DO - http://dx.doi.org/10.1029/1998JD100025 ER - TY - JOUR T1 - In Vivo Polysaccharide-Specific IgG Isotype Responses to Intact Streptococcus pneumoniae Are T Cell Dependent and Require CD40- and B7-Ligand Interactions AN - 17270404; 4567645 AB - In vivo Ig responses to soluble, haptenated polysaccharide (PS) Ags are T cell independent and do not require CD40 ligand (CD40L). However, little is known regarding the regulation of in vivo PS-specific Ig responses to intact bacteria. We immunized mice with a nonencapsulated, type 2 Streptococcus pneumoniae (R36A) and compared the parameters that regulated in vivo Ig isotype responses to the bacterial cell wall C-PS determinant, phosphorylcholine (PC), relative to Ig responses to the cell wall protein, pneumococcal surface protein A. Consistent with previous reports using soluble PS and protein Ags, the anti-PC and anti-pneumococcal surface protein A responses differed in that the anti-PC response was induced more rapidly, had a distinctive Ig isotype profile, and failed to demonstrate boosting upon secondary challenge with R36A. However, in contrast to previous studies, the IgG anti-PC response was TCR- alpha beta super(+) T cell dependent, required CD40L, and was blocked by administration of CTLA4 Ig. The nature of the T cell help for the anti-PC response had distinct features in that it was only partially blocked by CTLA4 Ig and was dependent upon both CD4 super(+) and CD8 super(+) T cells. Surprisingly, whereas the IgM anti-PC response was largely T cell independent, a strong requirement for CD40L was still observed, suggesting the possibility of an in vivo T cell-independent source for CD40L-dependent help. These data suggest that the regulatory parameters that govern in vivo Ig responses to purified, soluble PS Ags may not adequately account for PS-specific Ig responses to intact bacteria. JF - Journal of Immunology AU - Wu, Zheng-Qi AU - Vos, Q AU - Shen, Yi AU - Lees, A AU - Wilson AU - Briles, DE AU - Gause, W C AU - Mond, J J AU - Snapper, C M AD - Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA, csnapper@usuhs.mil Y1 - 1999/07/15/ PY - 1999 DA - 1999 Jul 15 SP - 659 EP - 667 VL - 163 IS - 2 SN - 0022-1767, 0022-1767 KW - CD40L protein KW - Streptococcus pneumoniae KW - double prime B7 antigen KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Lymphocytes T KW - Immunoglobulin G KW - Antibody response KW - Polysaccharides KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17270404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=In+Vivo+Polysaccharide-Specific+IgG+Isotype+Responses+to+Intact+Streptococcus+pneumoniae+Are+T+Cell+Dependent+and+Require+CD40-+and+B7-Ligand+Interactions&rft.au=Wu%2C+Zheng-Qi%3BVos%2C+Q%3BShen%2C+Yi%3BLees%2C+A%3BWilson%3BBriles%2C+DE%3BGause%2C+W+C%3BMond%2C+J+J%3BSnapper%2C+C+M&rft.aulast=Wu&rft.aufirst=Zheng-Qi&rft.date=1999-07-15&rft.volume=163&rft.issue=2&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Immunoglobulin G; Polysaccharides; Antibody response; Lymphocytes T ER - TY - JOUR T1 - Effectiveness of RSVIG prophylaxis and therapy of respiratory syncytial virus in an immunosuppressed animal model. AN - 69935911; 10435733 AB - Respiratory syncytial virus (RSV) has emerged as a leading cause of pneumonia, with high mortality, in bone marrow transplant (BMT) recipients, as well as in other profoundly immunocompromised patients, such as myelosuppressed adults with leukemia. We tested the efficacy of immunoglobulin with high anti-RSV neutralizing antibody levels (RSVIG) for prophylaxis and therapy of RSV infection in cotton rats undergoing prolonged immunosuppression with cyclophosphamide. These animals experience persistent infection, a model which is similar to the disease seen in post-BMT humans. Both prophylaxis and therapy reduced pulmonary viral replication over 500-fold to nearly undetectable levels. In animals receiving continual immunosuppression, the use of multiple therapeutic doses of RSVIG was able to prevent rebound viral replication, though virus was not completely eliminated. JF - Bone marrow transplantation AU - Ottolini, M G AU - Porter, D D AU - Hemming, V G AU - Zimmerman, M N AU - Schwab, N M AU - Prince, G A AD - Department of Pediatrics, F Edward Herbert School of Medicine, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 1999/07// PY - 1999 DA - July 1999 SP - 41 EP - 45 VL - 24 IS - 1 SN - 0268-3369, 0268-3369 KW - Antibodies, Viral KW - 0 KW - Immunoglobulins, Intravenous KW - Immunosuppressive Agents KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Virus Replication KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Dose-Response Relationship, Immunologic KW - Disease Models, Animal KW - Nose -- virology KW - Sigmodontinae KW - Lung -- virology KW - Cyclophosphamide -- pharmacology KW - Immunoglobulins, Intravenous -- therapeutic use KW - Antibodies, Viral -- therapeutic use KW - Respiratory Syncytial Viruses -- immunology KW - Respiratory Syncytial Viruses -- growth & development KW - Respiratory Syncytial Virus Infections -- prevention & control KW - Immunosuppressive Agents -- therapeutic use KW - Immunoglobulins, Intravenous -- adverse effects KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69935911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bone+marrow+transplantation&rft.atitle=Effectiveness+of+RSVIG+prophylaxis+and+therapy+of+respiratory+syncytial+virus+in+an+immunosuppressed+animal+model.&rft.au=Ottolini%2C+M+G%3BPorter%2C+D+D%3BHemming%2C+V+G%3BZimmerman%2C+M+N%3BSchwab%2C+N+M%3BPrince%2C+G+A&rft.aulast=Ottolini&rft.aufirst=M&rft.date=1999-07-01&rft.volume=24&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Bone+marrow+transplantation&rft.issn=02683369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-10-08 N1 - Date created - 1999-10-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oral leukoplakia status six weeks after cessation of smokeless tobacco use. AN - 69917473; 10422398 AB - This study evaluated the prevalence and risk of developing oral leukoplakia in smokeless tobacco, or ST, users and the response of these leukoplakic lesions after six weeks of involuntary tobacco cessation. U.S. Air Force basic military training provided an environment of a mandatorily tobacco-free setting. The authors designed their investigation as a case control study with a nested cohort study. The principal investigator (G.C.M.) conducted oral examinations of 3,051 male U.S. Air Force basic military trainees. Using a questionnaire, he obtained detailed information concerning subjects' ST use patterns before basic training. Clinical photos were taken of all leukoplakic lesions identified in ST users at the initial examination and again six weeks later. Of the 3,051 male trainees examined (mean age = 19.5 years), 9.9 percent (302/3,051) were identified as current ST users. Among current ST users, 39.4 percent (119/302) had leukoplakia vs. 1.5 percent (42/2,749) of nonusers of ST (odds ratio = 41.9, 95 percent confidence interval = 28.1-62.6). At the end of the involuntary cessation of tobacco use, 97.5 percent of these leukoplakic lesions had complete clinical resolution. The type of ST used (snuff vs. chewing tobacco), amount used (cans or pouches per day), length of use (months), number of days since last use and brand of snuff used were significantly associated with the risk of developing leukoplakic lesions among ST users. The important new finding from this investigation is that if a young, otherwise healthy man with leukoplakic lesions stops using tobacco for six weeks, most of his leukoplakic lesions will resolve clinically. Use of ST, specifically snuff, is strongly associated with development of oral leukoplakia in young adult men. The clinician can use these findings in deciding when to perform biopsies on leukoplakic lesions associated with ST use. This information also should be used to assist ST users in quitting this addictive behavior. JF - Journal of the American Dental Association (1939) AU - Martin, G C AU - Brown, J P AU - Eifler, C W AU - Houston, G D AD - Tri-Service Center for Oral Health Studies, Uniformed Services, University of the Health Sciences, Bethesda, Md. 20814-4799, USA. Y1 - 1999/07// PY - 1999 DA - July 1999 SP - 945 EP - 954 VL - 130 IS - 7 SN - 0002-8177, 0002-8177 KW - Dentistry KW - Index Medicus KW - Humans KW - Tobacco Use Disorder -- epidemiology KW - Remission, Spontaneous KW - Multivariate Analysis KW - Military Personnel KW - Adult KW - Aerospace Medicine KW - Surveys and Questionnaires KW - Tobacco Use Disorder -- prevention & control KW - Tobacco Use Disorder -- etiology KW - United States -- epidemiology KW - Time Factors KW - Male KW - Prevalence KW - Plants, Toxic KW - Leukoplakia, Oral -- etiology KW - Tobacco, Smokeless -- adverse effects KW - Leukoplakia, Oral -- prevention & control KW - Tobacco Use Cessation KW - Leukoplakia, Oral -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69917473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Oral+leukoplakia+status+six+weeks+after+cessation+of+smokeless+tobacco+use.&rft.au=Martin%2C+G+C%3BBrown%2C+J+P%3BEifler%2C+C+W%3BHouston%2C+G+D&rft.aulast=Martin&rft.aufirst=G&rft.date=1999-07-01&rft.volume=130&rft.issue=7&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-08-04 N1 - Date created - 1999-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Dent Assoc. 1999 Nov;130(11):1558 [10573921] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Both neutralization resistance and high infectivity phenotypes are caused by mutations of interacting residues in the human immunodeficiency virus type 1 gp41 leucine zipper and the gp120 receptor- and coreceptor-binding domains. AN - 69823350; 10364321 AB - Neutralization resistance of human immunodeficiency virus type 1 (HIV-1) is a major impediment to vaccine development. We have found that residues of HIV-1 MN strain in the C terminus of gp120 and the leucine zipper (LZ) region of gp41 viral envelope proteins interact cooperatively to determine neutralization resistance and modulate infectivity. Further, results demonstrate that this interaction, by which regions of gp120 are assembled onto the LZ, involves amino acid residues intimately related to those which participate in the binding of the envelope to its receptor and coreceptor. Variations in this critical assembly structure determine the concordant, interdependent evolution of increased infectivity efficiency and neutralization resistance phenotypes of the envelopes. The results elucidate important structure-function relationships among epitopes that are important targets of vaccine development. JF - Journal of virology AU - Park, E J AU - Quinnan, G V AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1999/07// PY - 1999 DA - July 1999 SP - 5707 EP - 5713 VL - 73 IS - 7 SN - 0022-538X, 0022-538X KW - Antigens, CD4 KW - 0 KW - HIV Envelope Protein gp120 KW - HIV Envelope Protein gp41 KW - Receptors, CXCR4 KW - Index Medicus KW - AIDS/HIV KW - Phenotype KW - Mutagenesis, Site-Directed KW - Humans KW - Neutralization Tests KW - Binding Sites KW - HIV-1 -- genetics KW - Leucine Zippers -- genetics KW - HIV-1 -- immunology KW - HIV Envelope Protein gp120 -- immunology KW - Leucine Zippers -- immunology KW - HIV Envelope Protein gp41 -- metabolism KW - HIV Envelope Protein gp41 -- genetics KW - Receptors, CXCR4 -- metabolism KW - HIV Envelope Protein gp41 -- immunology KW - HIV Envelope Protein gp120 -- metabolism KW - HIV Envelope Protein gp120 -- genetics KW - HIV-1 -- physiology KW - Antigens, CD4 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69823350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Both+neutralization+resistance+and+high+infectivity+phenotypes+are+caused+by+mutations+of+interacting+residues+in+the+human+immunodeficiency+virus+type+1+gp41+leucine+zipper+and+the+gp120+receptor-+and+coreceptor-binding+domains.&rft.au=Park%2C+E+J%3BQuinnan%2C+G+V&rft.aulast=Park&rft.aufirst=E&rft.date=1999-07-01&rft.volume=73&rft.issue=7&rft.spage=5707&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-23 N1 - Date created - 1999-07-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: AIDS Res Hum Retroviruses. 1990 Jun;6(6):703-6 [2364015] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12303-8 [9356444] J Virol. 1990 Dec;64(12):5701-7 [2243375] J Virol. 1991 Jan;65(1):489-93 [1702163] J Acquir Immune Defic Syndr. 1991;4(6):623-7 [2023103] Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8949-52 [1717992] Science. 1991 Oct 4;254(5028):105-8 [1718036] J Virol. 1992 Jan;66(1):524-33 [1727497] J Virol. 1992 May;66(5):3125-30 [1373203] J Immunol. 1992 May 15;148(10):3055-61 [1374448] J Immunol. 1992 Jul 15;149(2):649-54 [1378074] AIDS Res Hum Retroviruses. 1992 Aug;8(8):1461-5 [1281659] J Virol. 1993 Feb;67(2):863-75 [7678308] J Virol. 1993 Jul;67(7):3978-88 [7685405] J Virol. 1993 Aug;67(8):4932-44 [7687306] J Virol. 1993 Nov;67(11):6897-902 [8411395] J Virol. 1994 Feb;68(2):674-80 [7507184] Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9770-4 [7937889] J Biomol Struct Dyn. 1997 Dec;15(3):465-71 [9439994] Science. 1998 Jun 19;280(5371):1884-8 [9632381] Science. 1998 Jun 19;280(5371):1949-53 [9632396] Nature. 1998 Jun 18;393(6686):648-59 [9641677] Nature. 1998 Jun 18;393(6686):705-11 [9641684] AIDS Res Hum Retroviruses. 1998 Jul 20;14(11):939-49 [9686640] J Virol. 1998 Sep;72(9):7099-107 [9696803] Virology. 1986 Apr 15;150(1):283-90 [3006341] Ann Intern Med. 1987 Sep;107(3):286-92 [2441634] Cell. 1988 Jul 1;54(1):57-63 [2838179] J Virol. 1989 Sep;63(9):3595-600 [2547987] AIDS. 1989 Dec;3(12):777-84 [2483618] J Virol. 1995 Jun;69(6):3771-7 [7538176] AIDS Res Hum Retroviruses. 1995 Jul;11(7):783-7 [7546904] AIDS Res Hum Retroviruses. 1995 Sep;11(9):1131-3 [8554911] Nat Struct Biol. 1995 Dec;2(12):1075-82 [8846219] EMBO J. 1996 Apr 1;15(7):1507-14 [8612573] J Virol. 1996 Aug;70(8):5306-11 [8764041] Cell. 1997 Apr 18;89(2):263-73 [9108481] Nature. 1997 May 22;387(6631):426-30 [9163431] J Virol. 1990 Aug;64(8):3779-91 [2370681] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Winter prey selection by wolves and cougars in and near Glacier National Park, Montana AN - 17446535; 4658844 AB - Expansion by wolf (Canis lupus) populations in the western United States creates new opportunities and challenges for researching and managing large mammal predator-prey systems. Therefore, we compared patterns of prey selection between wolves and cougars (Puma concolor) to ascertain the effects of multiple predators on prey and on each other. Because of differences in hunting techniques, we predicted that wolves would kill more vulnerable classes of prey than cougars. Our results did not support this prediction. Whitetailed deer (Odocoileus virginianus) composed the greatest proportion of wolf (0.83) and cougar kills (0.87), but elk (Cervus elaphus) and moose (Alces alces) composed a larger proportion of wolf (0.14, 0.03, respectively) than cougar (0.06, 0.02, respectively) kills. Wolves and cougars selected older and younger deer and elk than did hunters. Cougars killed relatively more bull elk (0.74) than did wolves (0.48). Male deer killed by cougars had shorter diastema lengths than did male deer killed by wolves (P = 0.02). Pack hunting by wolves and dense stalking cover may have partially explained the failure to support predictions of the coursing versus stalking dichotomy. Wolves and cougars may be exhibiting exploitation and interference competition that is affecting each others' behavior and dynamics, and that of their prey. JF - Journal of Wildlife Management AU - Kunkel, KE AU - Ruth, T K AU - Pletscher, D H AU - Hornocker, M G AD - National Park Service, Alaska Regional Office, 2525 Gambell Street, Anchorage, AK 99503, USA, kyran_kunkel@nps.gov Y1 - 1999/07// PY - 1999 DA - Jul 1999 VL - 63 IS - 3 SN - 0022-541X, 0022-541X KW - Ecology Abstracts KW - Wildlife management KW - D 04700:Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17446535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Wildlife+Management&rft.atitle=Winter+prey+selection+by+wolves+and+cougars+in+and+near+Glacier+National+Park%2C+Montana&rft.au=Kunkel%2C+KE%3BRuth%2C+T+K%3BPletscher%2C+D+H%3BHornocker%2C+M+G&rft.aulast=Kunkel&rft.aufirst=KE&rft.date=1999-07-01&rft.volume=63&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Wildlife+Management&rft.issn=0022541X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Wildlife management ER - TY - JOUR T1 - Identification and Characterization of a New Lipoprotein, NlpI, in Escherichia coli K-12 AN - 17361885; 4566081 AB - We report here the identification of a new lipoprotein, NlpI, in Escherichia coli K-12. The NlpI structural gene (nlpI) is located between the genes pnp (polynucleotide phosphorylase) and deaD (RNA helicase) at 71 min on the E. coli chromosome. The nlpI gene encodes a putative polypeptide of approximately 34 kDa, and multiple lines of evidence clearly demonstrate that NlpI is indeed a lipoprotein. An nlpI::cm mutation rendered growth of the cells osmotically sensitive, and incubation of the insertion mutant at an elevated temperature resulted in the formation of filaments. The altered phenotype of the mutant was a direct consequence of the mutation in nlpI, since it was complemented by the wild-type nlpI gene alone. Overexpression of the unaltered nlpI gene in wild-type cells resulted in the loss of the rod morphology and the formation of single prolate ellipsoids and pairs of prolate ellipsoids joined by partial constrictions. NlpI may be important for an as-yet-undefined step in the overall process of cell division. JF - Journal of Bacteriology AU - Ohara, M AU - Wu, H C AU - Sankaran , K AU - Rick, P D AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, Rickp@usuhs.mil Y1 - 1999/07// PY - 1999 DA - Jul 1999 SP - 4318 EP - 4325 VL - 181 IS - 14 SN - 0021-9193, 0021-9193 KW - NlpI protein KW - polynucleotide phosphorylase KW - polyribonucleotide nucleotidyltransferase KW - Microbiology Abstracts B: Bacteriology KW - Cell division KW - Escherichia coli KW - Identification KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17361885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Identification+and+Characterization+of+a+New+Lipoprotein%2C+NlpI%2C+in+Escherichia+coli+K-12&rft.au=Ohara%2C+M%3BWu%2C+H+C%3BSankaran+%2C+K%3BRick%2C+P+D&rft.aulast=Ohara&rft.aufirst=M&rft.date=1999-07-01&rft.volume=181&rft.issue=14&rft.spage=4318&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Identification; Cell division ER - TY - JOUR T1 - Regulation of IFN consensus sequence binding protein expression in murine macrophages. AN - 69809273; 10358195 AB - Recent work has demonstrated that the transcription factor, IFN consensus sequence binding protein (ICSBP), plays a critical role in the capacity of mice to control infection with Toxoplasma gondii and Leishmania major, agents that require highly activated macrophages for their elimination. In this report the regulation of ICSBP mRNA and protein were analyzed in murine macrophages stimulated with LPS and/or IFN-gamma. Like induction of leishmaniacidal activity, LPS and IFN-gamma synergize to induce ICSBP mRNA and protein. Deletion analysis of the ICSBP promoter identified regions that were IFN-gamma responsive, regions that mediate the ability of LPS and IFN-gamma to activate this promoter synergistically, as well as regions that normally repress ICSBP transcription. Finally, exogenous expression of ICSBP, found in previous studies to down-regulate MHC I gene expression, failed to repress basal or IFN-gamma-induced ICSBP transcription. This demonstrates that ICSBP can selectively suppress the expression of IFN-responsive genes. These findings extend in a significant way our understanding of the regulation of ICSBP by LPS and IFN-gamma and provide important clues as to its role in macrophage activation. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Kantakamalakul, W AU - Politis, A D AU - Marecki, S AU - Sullivan, T AU - Ozato, K AU - Fenton, M J AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 1999/06/15/ PY - 1999 DA - 1999 Jun 15 SP - 7417 EP - 7425 VL - 162 IS - 12 SN - 0022-1767, 0022-1767 KW - DNA-Binding Proteins KW - 0 KW - Interferon Regulatory Factor-1 KW - Interferon Regulatory Factors KW - Irf1 protein, mouse KW - Lipopolysaccharides KW - Phosphoproteins KW - Proto-Oncogene Proteins KW - RNA, Messenger KW - Repressor Proteins KW - Trans-Activators KW - interferon regulatory factor-8 KW - proto-oncogene protein Spi-1 KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Protein Biosynthesis KW - Animals KW - Promoter Regions, Genetic -- immunology KW - Gene Expression Regulation -- immunology KW - Lipopolysaccharides -- pharmacology KW - Phosphoproteins -- physiology KW - Mice KW - RNA, Messenger -- biosynthesis KW - Proto-Oncogene Proteins -- physiology KW - Mice, Inbred C3H KW - DNA-Binding Proteins -- physiology KW - Trans-Activators -- physiology KW - Drug Synergism KW - Cell Line KW - Female KW - Sequence Deletion KW - Repressor Proteins -- biosynthesis KW - Consensus Sequence -- genetics KW - Repressor Proteins -- physiology KW - Consensus Sequence -- immunology KW - Macrophages, Peritoneal -- metabolism KW - Interferon-gamma -- biosynthesis KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69809273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Regulation+of+IFN+consensus+sequence+binding+protein+expression+in+murine+macrophages.&rft.au=Kantakamalakul%2C+W%3BPolitis%2C+A+D%3BMarecki%2C+S%3BSullivan%2C+T%3BOzato%2C+K%3BFenton%2C+M+J%3BVogel%2C+S+N&rft.aulast=Kantakamalakul&rft.aufirst=W&rft.date=1999-06-15&rft.volume=162&rft.issue=12&rft.spage=7417&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-06-30 N1 - Date created - 1999-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Breast cancer screening. AN - 69903172; 10414706 AB - Three breast cancer screening methods are commonly employed: mammography, breast self examination (BSE), and physical examination by trained personnel (PE). Case-control, retrospective, and prospective studies have examined the efficacy of these screening modalities in reducing breast cancer mortality. However, there are three biases pertinent to many of these studies: lead-time, length, and selection biases. The best way to exclude these biases is to compare screened and unscreened women in a randomized controlled trial with breast cancer mortality as the end point. Eight trials have examined the effect of mammographic screening on breast cancer mortality and two have examined the impact of screening with BSE. In addition, a large trial will soon be initiated in India to assess the impact of screening by PE on breast cancer mortality. This article reviews these trials and discusses the implications of the studies. The overall results of the randomized controlled trials indicate that mammographic screening in women over age 50 can reduce breast cancer mortality by about 25%. However, its efficacy in women between the ages of 40 and 49 is disputed, and another large trial has been initiated in the United Kingdom to resolve this controversy. Preliminary results of two trials indicate that BSE has no impact on breast cancer mortality. However, longer follow-up of these trials is necessary before drawing any conclusions regarding BSE. Mammographic screening in postmenopausal women is an effective means of reducing breast cancer mortality. However, the impact of mammographic screening on breast cancer mortality in premenopausal women is disputed. At least four potentially harmful consequences of mammographic screening merit consideration: lead time effect, radiation exposure, false-positives, and overdiagnosis. Thus, women between the ages of 40 and 49, in particular, should be informed of the potential for benefit and harm prior to mammographic screening. JF - American journal of surgery AU - Jatoi, I AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 1999/06// PY - 1999 DA - June 1999 SP - 518 EP - 524 VL - 177 IS - 6 SN - 0002-9610, 0002-9610 KW - Abridged Index Medicus KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Mammography KW - Radiation Protection KW - Postmenopause KW - Breast Self-Examination KW - Premenopause KW - Humans KW - Adult KW - Middle Aged KW - Physical Examination KW - Female KW - Mass Screening -- statistics & numerical data KW - Breast Neoplasms -- diagnosis KW - Breast Neoplasms -- prevention & control KW - Mass Screening -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69903172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+surgery&rft.atitle=Breast+cancer+screening.&rft.au=Jatoi%2C+I&rft.aulast=Jatoi&rft.aufirst=I&rft.date=1999-06-01&rft.volume=177&rft.issue=6&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=American+journal+of+surgery&rft.issn=00029610&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-08-09 N1 - Date created - 1999-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational Back Disability in U.S. Army Personnel AN - 17489208; 4686714 AB - Musculoskeletal disorders represent a prevalent source of outpatient visits, lost work time, hospitalization, and disability in the military. Recent research has identified patterns among military occupations, gender, and musculoskeletal disability. Although back disorders accounted for a high percentage of all cases, little is known about the relationship between job type and disability in soldiers. The present study analyzed 41,750 disability cases to determine (1) prevalence of work-related back disability diagnoses, (2) specific jobs associated with greater risk of back disability, and (3) association among gender, job type, and disability. The results indicate that (1) lumbosacral strain and intervertebral disc syndrome represent the most prevalent diagnoses for back disability, (2) certain occupations were associated with higher back disability risk, and (3) specific jobs were identified in which females experienced higher rates of back disability than males. JF - Military Medicine AU - Berkowitz, S M AU - Feuerstein, M AU - Lopez AU - Peck, CA Jr AD - Uniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology (MPS), Bethesda, MD 20814-4799, USA Y1 - 1999/06// PY - 1999 DA - Jun 1999 SP - 412 EP - 418 VL - 164 IS - 6 SN - 0026-4075, 0026-4075 KW - back KW - disabilities KW - musculoskeletal system KW - working conditions KW - Health & Safety Science Abstracts KW - Risk assessment KW - Injuries KW - Gender KW - Military KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17489208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Medicine&rft.atitle=Occupational+Back+Disability+in+U.S.+Army+Personnel&rft.au=Berkowitz%2C+S+M%3BFeuerstein%2C+M%3BLopez%3BPeck%2C+CA+Jr&rft.aulast=Berkowitz&rft.aufirst=S&rft.date=1999-06-01&rft.volume=164&rft.issue=6&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=Military+Medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational health; Military; Injuries; Gender; Risk assessment ER - TY - JOUR T1 - National park and reserve planning to protect biological diversity: some basic elements AN - 19930165; 4570651 AB - Key needs for the creation of a nature reserve system are outlined: formulating goals, selecting management categories, taking inventory, identifying gaps, designing reserves, measuring reserve condition and vulnerability, and recognizing the relationship between research and management. Some essential components are highlighted: a regional perspective, diversification of management categories, focus on the economics of human welfare, not ignoring the opportunities small reserves can provide for some biota, addition of marine reserves, and the importance of a focus on natural processes. The view some Americans have of indigenous people and protected areas is not compatible with third world realities. Since the problems and challenges of protecting areas in northern and southern countries are alike in many ways, however, a Eurocentric seeking to articulate the special circumstances faced by tropical countries offers these suggestions. JF - Landscape and Urban Planning AU - Shafer, CL AD - National Park Service, Natural Resources, Stewardship and Science, 1849 C. Street, N.W., Washington DC 20240-0001, USA, craig_shafer@nps.gov Y1 - 1999/05/10/ PY - 1999 DA - 1999 May 10 SP - 123 EP - 153 VL - 44 IS - 2-3 SN - 0169-2046, 0169-2046 KW - Indigenous peoples KW - Sustainability Science Abstracts; Ecology Abstracts; Human Population KW - National parks KW - Biological diversity KW - Environmental protection KW - Socio-economic aspects KW - USA KW - Nature conservation KW - Nature reserves KW - Developing countries KW - Environment management KW - M1 320:Environmental & Natural Resource Development KW - M3 1010:Issues in Sustainable Development KW - D 04705:Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19930165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Landscape+and+Urban+Planning&rft.atitle=National+park+and+reserve+planning+to+protect+biological+diversity%3A+some+basic+elements&rft.au=Shafer%2C+CL&rft.aulast=Shafer&rft.aufirst=CL&rft.date=1999-05-10&rft.volume=44&rft.issue=2-3&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Landscape+and+Urban+Planning&rft.issn=01692046&rft_id=info:doi/10.1016%2FS0169-2046%2898%2900115-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 1999-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; National parks; Nature reserves; Biological diversity; Environment management; Socio-economic aspects; Environmental protection; Developing countries; Nature conservation DO - http://dx.doi.org/10.1016/S0169-2046(98)00115-7 ER - TY - JOUR T1 - Interference by aerobic and anaerobic bacteria in children with recurrent group A beta-hemolytic streptococcal tonsillitis. AN - 85300054; pmid-10326813 AB - OBJECTIVE: To compare the frequency of recovery of aerobic and anaerobic bacteria with interfering capability of group A beta-hemolytic streptococci (GABHS) in the tonsils of children with and without a history of recurrent GABHS pharyngotonsillitis. PATIENTS AND METHODS: Tonsillar cultures were taken from a group of 20 children with and 20 without history of recurrent GABHS pharyngotonsillitis. RESULTS: Eleven aerobic and anaerobic isolates with interfering capability with GABHS were recovered from 6 (30%) of the 20 children with recurrent GABHS, and 40 such organisms were isolated from 17 (85%) of the 20 without recurrences (P<.01). The interfering organisms included aerobic (alpha-hemolytic and nonhemolytic streptococci) and anaerobic organisms (Prevotella and Peptostreptococcus species). CONCLUSIONS: The tonsils of children with a history of recurrent GABHS infection contain fewer aerobic and anaerobic bacteria with interfering capability of GABHS than those without the history of recurrent GABHS infection. The presence of these interfering bacteria may play a role in preventing GABHS infection. JF - Archives of otolaryngology--head & neck surgery AU - Brook, I AU - Gober, A E AD - Department of Pediatrics, Georgetown University, School of Medicine, Washington, DC, USA. Brook@mx.afrri.usuhs.mil Y1 - 1999/05// PY - 1999 DA - May 1999 SP - 552 EP - 554 VL - 125 IS - 5 SN - 0886-4470, 0886-4470 KW - Abridged Index Medicus; Index Medicus KW - National Library of Medicine KW - Humans KW - Prevotella -- isolation & purification KW - Child KW - Peptostreptococcus -- isolation & purification KW - Adolescent KW - Male KW - Female KW - Recurrence KW - Peptostreptococcus -- physiology KW - Prevotella -- physiology KW - Child, Preschool KW - Streptococcal Infections -- physiopathology KW - Bacteria, Anaerobic -- physiology KW - Bacteria, Aerobic -- physiology KW - Tonsillitis -- microbiology KW - Antibiosis KW - Oropharynx -- microbiology KW - Streptococcus pyogenes -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85300054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+otolaryngology--head+%26+neck+surgery&rft.atitle=Interference+by+aerobic+and+anaerobic+bacteria+in+children+with+recurrent+group+A+beta-hemolytic+streptococcal+tonsillitis.&rft.au=Brook%2C+I%3BGober%2C+A+E&rft.aulast=Brook&rft.aufirst=I&rft.date=1999-05-01&rft.volume=125&rft.issue=5&rft.spage=552&rft.isbn=&rft.btitle=&rft.title=Archives+of+otolaryngology--head+%26+neck+surgery&rft.issn=08864470&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Characterization of the bacterial community of a zinc-polluted soil. AN - 69918631; 10420584 AB - The bacterial community of a zinc-contaminated soil (Maatheide soil in Lommel, Belgium) was studied using cultivation as well as cultivation-independent techniques. Colony-forming units (CFU) were determined by plating on media with or without metals. Dominant isolates were characterized by fatty acid methyl ester analysis (FAME analysis) and PCR fingerprinting using repetitive extragenic palindromic sequences as primers. DNA was directly extracted from soil samples and used as a template for the PCR amplification of the 16S rDNA (8-1511) or a 16S rDNA fragment (968-1401). Clones resulting from cloning the 16S rDNA from soil DNA were sequenced. Temperature gradient gel electrophoresis (TGGE analysis) was performed for 16S rDNA fragments (968-1401) amplified from the dominant isolates, the clones, and the total soil DNA extracted according to two protocols differing in strength of lysis. Total CFU ranged from 10(4) to 10(5)/g soil. The majority of the isolates were identified by FAME analysis as Arthrobacter spp. (18 out of 23). None of the isolates were identified as a Ralstonia eutropha like strain (formerly Alcaligenes eutrophus). Metalloresistant Rastomia eutropha like strains were previously shown to be dominant in the analyzed biotope. Most of the isolates were zinc tolerant but only seven could be considered zinc resistant. Sequences of the 16S rDNA clones obtained from total soil DNA were affiliated with genes of different bacteria such as alpha-proteobacteria, beta-proteobacteria, and the Cytophaga-Flexibacter-Bacteroides group. None of the sequenced clones aligned with the Ralstonia eutropha 16S rRNA gene. TGGE analysis of the 16S rDNA fragments (968-1401) amplified from the dominant strains, the clones, and the total soil DNA showed that isolates and clones represented only a part of the bands present in the TGGE pattern from total DNA. The 968-1401 fragment amplified from all Arthrobacter strains had a similar electrophoretic mobility. This band was seen as a major band in the pattern of DNA extracted from soil using a harsh cell lysis, whereas it did not appear, or appeared only as a weak band, in patterns obtained from soil DNA extracted using gentle lysis. The previously reported predominance of a Ralstonia eutropha like strain in this soil was no longer observed. This may suggest a population replacement by less resistant bacteria, concomitant with a progressive decrease of the zinc toxicity in the Maatheide soil. JF - Canadian journal of microbiology AU - Brim, H AU - Heuer, H AU - Krögerrecklenfort, E AU - Mergeay, M AU - Smalla, K AD - Environmental Technology (V.I.T.O.), Mol, Belgium. hbrim@mxb.usuhs.mil Y1 - 1999/04// PY - 1999 DA - April 1999 SP - 326 EP - 338 VL - 45 IS - 4 SN - 0008-4166, 0008-4166 KW - DNA, Bacterial KW - 0 KW - DNA, Ribosomal KW - Fatty Acids KW - RNA, Ribosomal, 16S KW - Soil Pollutants KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Soil Pollutants -- toxicity KW - Electrophoresis -- methods KW - RNA, Ribosomal, 16S -- genetics KW - DNA, Ribosomal -- chemistry KW - Sequence Analysis, DNA KW - Arthrobacter -- isolation & purification KW - Soil Pollutants -- analysis KW - Phenotype KW - Polymerase Chain Reaction KW - DNA, Bacterial -- chemistry KW - DNA, Bacterial -- genetics KW - Colony Count, Microbial KW - Bacteriological Techniques KW - DNA, Ribosomal -- genetics KW - Fatty Acids -- analysis KW - Bacteria -- genetics KW - Soil Microbiology KW - Zinc -- analysis KW - Zinc -- toxicity KW - Bacteria -- isolation & purification KW - Bacteria -- drug effects KW - Bacteria -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69918631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+microbiology&rft.atitle=Characterization+of+the+bacterial+community+of+a+zinc-polluted+soil.&rft.au=Brim%2C+H%3BHeuer%2C+H%3BKr%C3%B6gerrecklenfort%2C+E%3BMergeay%2C+M%3BSmalla%2C+K&rft.aulast=Brim&rft.aufirst=H&rft.date=1999-04-01&rft.volume=45&rft.issue=4&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=Canadian+journal+of+microbiology&rft.issn=00084166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-09-13 N1 - Date created - 1999-09-13 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - Y13327; GENBANK; Y11635; Y11622; Y13326; Y11634; Y11624; Y11633; Y11623; Y11632; Y11631; Y11630; Y13325; Y13324; Y11636; Y11637; Y11629; Y11627; Y11628; Y11625; Y11626 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiation injuries. AN - 69758809; 10331137 JF - Critical care clinics AU - Reeves, G I AD - Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA. reeves@mx.afrri.usuhs.mil Y1 - 1999/04// PY - 1999 DA - April 1999 SP - 457 EP - 473 VL - 15 IS - 2 SN - 0749-0704, 0749-0704 KW - Index Medicus KW - Neutropenia KW - Lymphocyte Count KW - Bacterial Infections -- etiology KW - Radioactive Hazard Release KW - Bacterial Infections -- prevention & control KW - Humans KW - Decontamination KW - Virus Diseases -- prevention & control KW - Bone Marrow Transplantation KW - Virus Diseases -- etiology KW - Radiation Injuries -- therapy KW - Radiation Injuries -- complications KW - Radiation Injuries -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69758809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+care+clinics&rft.atitle=Radiation+injuries.&rft.au=Reeves%2C+G+I&rft.aulast=Reeves&rft.aufirst=G&rft.date=1999-04-01&rft.volume=15&rft.issue=2&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=Critical+care+clinics&rft.issn=07490704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-01 N1 - Date created - 1999-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proposed maximum permissible exposure limits for ultrashort laser pulses. AN - 69641305; 10086595 AB - Recent studies have provided considerable ED50 data for both visible and near infrared wavelengths from single laser pulses below one nanosecond of exposure. The current ANSI Z136.1 standard does not offer an approved maximum permissible exposure limit for subnanosecond single laser pulses and the current suggested maximum permissible exposure limit may be overly conservative. Lacking an approved standard industrial, medical, educational, and military uses of these types of laser systems may be limited or prohibited. A new set of laser maximum permissible exposure limits for subnanosecond visible and near infrared single laser pulses is recommended, along with the steps taken to develop the proposed standard. JF - Health physics AU - Roach, W P AU - Johnson, T E AU - Rockwell, B A AD - Uniformed Services University of the Health Sciences, Department of Preventive Medicine and Biometrics, Bethesda, MD 20814, USA. Y1 - 1999/04// PY - 1999 DA - April 1999 SP - 349 EP - 354 VL - 76 IS - 4 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Regression Analysis KW - Animals KW - Infrared Rays KW - Macaca mulatta KW - Time Factors KW - Cornea -- radiation effects KW - Retina -- radiation effects KW - Occupational Exposure -- standards KW - Lasers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69641305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Proposed+maximum+permissible+exposure+limits+for+ultrashort+laser+pulses.&rft.au=Roach%2C+W+P%3BJohnson%2C+T+E%3BRockwell%2C+B+A&rft.aulast=Roach&rft.aufirst=W&rft.date=1999-04-01&rft.volume=76&rft.issue=4&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-04-21 N1 - Date created - 1999-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Primary structure of gamma-bungarotoxin, a new postsynaptic neurotoxin from venom of Bungarus multicinctus. AN - 69633531; 10082161 AB - The primary structure of gamma-bungarotoxin, a new toxin from Bungarus multicinctus venom, was determined using mass spectrometry and Edman degradation. The toxin has a mass of 7524.7 D and consists of 68 residues having the following sequence: MQCKTCSFYT CPNSETCPDG KNICVKRSWT AVRGDGPKRE IRRECAATCP PSKLGLTVFC CTTDNCNH. Gamma-bungarotoxin is structurally similar to both kappa-bungarotoxin and elapid long postsynaptic neurotoxins. Its C-terminal nine residues are identical to those of the kappa-toxins. Its disulfide bond locations appear identical to those of several elapid toxins of unknown pharmacology and its hydrophobicity profile is also strikingly similar. However, with an LD50 of 0.15 microg/g i.v. in mice, gamma-bungarotoxin is 30-150-fold more toxic than other members of this latter class. Its toxicity is comparable to those of alpha-nicotinic acetylcholine receptor antagonists. JF - Toxicon : official journal of the International Society on Toxinology AU - Aird, S D AU - Womble, G C AU - Yates, J R AU - Griffin, P R AD - NPS Pharmaceuticals, Salt Lake City, UT 84108, USA. sdaird@npd.ufpe.br Y1 - 1999/04// PY - 1999 DA - April 1999 SP - 609 EP - 625 VL - 37 IS - 4 SN - 0041-0101, 0041-0101 KW - Bungarotoxins KW - 0 KW - Neurotoxins KW - Receptors, Neurotransmitter KW - Index Medicus KW - Mass Spectrometry KW - Animals KW - Solubility KW - Chromatography KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - Male KW - Chromatography, High Pressure Liquid KW - Injections, Intraventricular KW - Bungarotoxins -- chemistry KW - Bungarus -- metabolism KW - Bungarotoxins -- toxicity KW - Receptors, Neurotransmitter -- drug effects KW - Neurotoxins -- toxicity KW - Neurotoxins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69633531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Primary+structure+of+gamma-bungarotoxin%2C+a+new+postsynaptic+neurotoxin+from+venom+of+Bungarus+multicinctus.&rft.au=Aird%2C+S+D%3BWomble%2C+G+C%3BYates%2C+J+R%3BGriffin%2C+P+R&rft.aulast=Aird&rft.aufirst=S&rft.date=1999-04-01&rft.volume=37&rft.issue=4&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-06-14 N1 - Date created - 1999-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development and application of an analytical model to aid design and implementation of in situ remediation technologies AN - 51018648; 1999-041620 AB - Innovative in situ remediation technologies using injection/extraction well pairs which recirculate partially treated groundwater as a method of increasing overall treatment efficiency have recently been demonstrated. An important parameter in determining overall treatment efficiency is the fraction of flow that recycles between injection and extraction points. Numerical and semi-analytical methods are currently available to determine this parameter and an analytical solution has been presented for a single injection/extraction well pair. In this work, the analytical solution for fraction of recycled flow for a single injection/extraction well pair is extended to multiple co-linear well pairs. In addition, a semi-analytical method is presented which permits direct calculation of fraction recycle for a system of arbitrarily placed injection/extraction wells pumping at different rates. The solution is used to investigate the behavior of multiple well pairs, looking at how well placement and pumping rates impact capture zone width and fraction recirculation (and, therefore, overall treatment efficiency). Results of the two-well solution are compared with data obtained at a recent field-scale demonstration of in situ aerobic cometabolic bioremediation, where a pair of dual-screened injection/extraction wells was evaluated. A numerical model is then used to evaluate the impact of hydraulic conductivity anisotropy on the overall treatment efficiency of the dual-screened injection/extraction well pair. The method presented here provides a fast and accurate technique for determining the efficacy of injection/extraction systems, and represents a tool that can be useful when designing such in situ treatment systems. JF - Journal of Contaminant Hydrology AU - Christ, John A AU - Goltz, Mark N AU - Huang, Junqi Y1 - 1999/04// PY - 1999 DA - April 1999 SP - 295 EP - 317 PB - Elsevier, Amsterdam VL - 37 IS - 3-4 SN - 0169-7722, 0169-7722 KW - numerical models KW - in situ KW - three-dimensional models KW - injection KW - optimization KW - techniques KW - mathematical models KW - migration of elements KW - fluid dynamics KW - remediation KW - ground water KW - aquifers KW - sensitivity analysis KW - hydraulic conductivity KW - waste disposal KW - disposal barriers KW - design KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51018648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Contaminant+Hydrology&rft.atitle=Development+and+application+of+an+analytical+model+to+aid+design+and+implementation+of+in+situ+remediation+technologies&rft.au=Christ%2C+John+A%3BGoltz%2C+Mark+N%3BHuang%2C+Junqi&rft.aulast=Christ&rft.aufirst=John&rft.date=1999-04-01&rft.volume=37&rft.issue=3-4&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Journal+of+Contaminant+Hydrology&rft.issn=01697722&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/01697722 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 1999-01-01 N1 - Number of references - 28 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aquifers; design; disposal barriers; fluid dynamics; ground water; hydraulic conductivity; in situ; injection; mathematical models; migration of elements; numerical models; optimization; remediation; sensitivity analysis; techniques; three-dimensional models; waste disposal ER - TY - JOUR T1 - Effects of sample size on kernel home range estimates AN - 17438434; 4658827 AB - Kernel methods for estimating home range are being used increasingly in wildlife research, but the effect of sample size on their accuracy is not known. We used computer simulations of 10-200 points/home range and compared accuracy of home range estimates produced by fixed and adaptive kernels with the reference (REF) and least-squares cross-validation (LSCV) methods for determining the amount of smoothing. Simulated home ranges varied from simple to complex shapes created by mixing bivariate normal distributions. We used the size of the 95% home range area and the relative mean squared error of the surface fit to assess the accuracy of the kernel home range estimates. For both measures, the bias and variance approached an asymptote at about 50 observations/home range. The fixed kernel with smoothing selected by LSCV provided the least-biased estimates of the 95% home range area. All kernel methods produced similar surface fit for most simulations, but the fixed kernel with LSCV had the lowest frequency and magnitude of very poor estimates. We reviewed 101 papers published in The Journal of Wildlife Management (JWM) between 1980 and 1997 that estimated animal home ranges. A minority of these papers used nonparametric utilization distribution (UD) estimators, and most did not adequately report sample sizes. We recommend that home range studies using kernel estimates use LSCV to determine the amount of smoothing, obtain a minimum of 30 observations per animal (but preferably greater than or equal to 50), and report sample sizes in published results. JF - Journal of Wildlife Management AU - Seaman, DE AU - Millspaugh, J J AU - Kernohan, B J AU - Brundige, G C AU - Raedeke, K J AU - Gitzen, R A AD - U.S. Geological Survey, Biological Resources Division, Forest and Rangeland Ecosystem Science Center, Olympic Field Station, 600 East Park Avenue, Port Angeles, WA 98362, USA, erran_seaman@nps.gov Y1 - 1999/04// PY - 1999 DA - Apr 1999 SP - 739 EP - 747 VL - 63 IS - 2 SN - 0022-541X, 0022-541X KW - Ecology Abstracts KW - Wildlife management KW - D 04700:Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17438434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Wildlife+Management&rft.atitle=Effects+of+sample+size+on+kernel+home+range+estimates&rft.au=Seaman%2C+DE%3BMillspaugh%2C+J+J%3BKernohan%2C+B+J%3BBrundige%2C+G+C%3BRaedeke%2C+K+J%3BGitzen%2C+R+A&rft.aulast=Seaman&rft.aufirst=DE&rft.date=1999-04-01&rft.volume=63&rft.issue=2&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Journal+of+Wildlife+Management&rft.issn=0022541X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Wildlife management ER - TY - JOUR T1 - Aerobic and Anaerobic Microbiology of Mycotic Aortic Aneurysm AN - 17369898; 4572394 AB - Identification of the organisms infecting aortic aneurysms is important, as these organisms can cause local and systemic infection, and can contaminate vascular prostheses. Various organisms have been found in mycotic aortic aneurysms (MAAs), including gram-positive aerobic bacteria such as Staphylococcus aureus and gram-negative aerobic bacteria such as Salmonella species. However, the recovery of anaerobic bacteria is rarely reported, as generally, most previous studies did not use proper methods for transportation and recovery of these organisms. Herein we review the 5-year experience of our hospital in the recovery of aerobic and anaerobic bacteria for cases of MAA. JF - Clinical Infectious Diseases AU - Brook, I AD - POB 70412, Chevy Chase, Maryland 20813-0412, USA, Brook@mx.afrri.usuhs.mil Y1 - 1999/04// PY - 1999 DA - Apr 1999 SP - 928 EP - 929 VL - 28 IS - 4 SN - 1058-4838, 1058-4838 KW - man KW - mycotic aortic aneurysm KW - Microbiology Abstracts B: Bacteriology KW - Aerobic bacteria KW - Anaerobic bacteria KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17369898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Aerobic+and+Anaerobic+Microbiology+of+Mycotic+Aortic+Aneurysm&rft.au=Brook%2C+I&rft.aulast=Brook&rft.aufirst=I&rft.date=1999-04-01&rft.volume=28&rft.issue=4&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Aerobic bacteria; Anaerobic bacteria ER - TY - JOUR T1 - The Mxi-Spa type III secretory pathway of Shigella flexneri requires an outer membrane lipoprotein, MxiM, for invasin translocation AN - 17217199; 4503793 AB - Invasion of epithelial cells by Shigella flexneri is mediated by a set of translocated bacterial invasins, the Ipa proteins, and its dedicated type III secretion system, called Mxi-Spa. We show here that mxiM, part of the mxi-spa locus in the S. flexneri virulence plasmid, encodes an indispensable type III secretion apparatus component, required for both Ipa translocation and tissue culture cell invasion. We demonstrated that mature MxiM, first identified as a putative lipoprotein, is lipidated in vivo. Consistent with features of known lipoproteins, MxiM (i) can be labeled with [ super(3)H]palmitate and [2- super(3)H]glycerol, (ii) is associated with the cell envelope, (III) is secreted independently of the type III pathway, and (iv) requires an intact lipoprotein modification and processing site for full activity. The lipidated form of MxiM was detected primarily in the outer membrane, where it establishes a peripheral association with the inner leaflet. Through analysis of subcellular Ipa distribution in a mxiM null mutant background, MxiM was found to be required for the assembly and/or function of outer, but not inner, membrane regions of Mxi-Spa. This function probably requires interactions with other Mxi-Spa subunits within the periplasmic space. We discuss implications of these findings with respect to the function of MxiM and the structure of Mxi-Spa as a whole. JF - Infection and Immunity AU - Schuch, R AU - Maurelli, A T AD - Department of Microbiology and Immunology, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA, amaurelli@mxb.usuhs.mil Y1 - 1999/04// PY - 1999 DA - Apr 1999 SP - 1982 EP - 1991 VL - 67 IS - 4 SN - 0019-9567, 0019-9567 KW - Ipa protein KW - Mxi-Spa protein KW - MxiM protein KW - mxiM gene KW - Microbiology Abstracts B: Bacteriology KW - Shigella flexneri KW - Outer membranes KW - Lipoproteins KW - Proteins KW - Plasmids KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17217199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+Mxi-Spa+type+III+secretory+pathway+of+Shigella+flexneri+requires+an+outer+membrane+lipoprotein%2C+MxiM%2C+for+invasin+translocation&rft.au=Schuch%2C+R%3BMaurelli%2C+A+T&rft.aulast=Schuch&rft.aufirst=R&rft.date=1999-04-01&rft.volume=67&rft.issue=4&rft.spage=1982&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Shigella flexneri; Plasmids; Lipoproteins; Proteins; Outer membranes ER - TY - JOUR T1 - Use of the superior meatus and superior turbinate in the endoscopic approach to the sphenoid sinus. AN - 85317969; pmid-10064630 AB - Endoscopic surgery of the posterior ethmoid and sphenoid sinuses can present the operator with a considerable challenge. Although endoscopic training and physician experience have increased significantly in the past decade, surgical complications such as optic nerve trauma and cerebrospinal fluid leak still occur. Surgeons reporting such complications cite a lack of orientation within the dissection field as a primary cause. Because endoscopic sinus surgery is now being performed more routinely, surgical strategies designed to reduce the risk of complications are more important than ever. An anatomic landmark that could reliably orient the dissection within the posterior ethmoids and guide the surgeon to the sphenoid sinus could reduce the possibility of such adverse outcomes. In our experience identification of the superior meatus and superior turbinate provides a reliable landmark within the dissection field that can ensure surgical orientation to the operator. This technique allows safe, reliable dissection of the posterior ethmoids and an efficient approach to the sphenoid sinus, especially in patients undergoing revision surgery. In this article our technique for the identification and definition of the superior meatus and superior turbinate is presented, and the advantages of using this landmark in sinus surgery are discussed. In our experience identification of the superior meatus, superior turbinate, posterior skull base, and medial orbital wall defines a parallelogram-shaped box, which delineates the sphenoid face. This box provides the necessary orientation to guide the surgeon's entrance into the sphenoid sinus through the posterior ethmoid sinus (as Messerklinger described). Techniques for identifying the superior turbinate and meatus and for entering the sphenoid are detailed. JF - Otolaryngology and head and neck surgery AU - Bolger, W E AU - Keyes, A S AU - Lanza, D C AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20817, USA. Y1 - 1999/03// PY - 1999 DA - March 1999 SP - 308 EP - 313 VL - 120 IS - 3 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Orbit -- anatomy & histology KW - Otorhinolaryngologic Surgical Procedures -- methods KW - Skull Base -- anatomy & histology KW - Humans KW - Endoscopy -- adverse effects KW - Endoscopy -- methods KW - Otorhinolaryngologic Surgical Procedures -- instrumentation KW - Otorhinolaryngologic Surgical Procedures -- adverse effects KW - Endoscopes KW - Anthropometry -- methods KW - Nasal Bone -- anatomy & histology KW - Sphenoid Sinus -- surgery KW - Dissection -- methods KW - Turbinates -- anatomy & histology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85317969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology+and+head+and+neck+surgery&rft.atitle=Use+of+the+superior+meatus+and+superior+turbinate+in+the+endoscopic+approach+to+the+sphenoid+sinus.&rft.au=Bolger%2C+W+E%3BKeyes%2C+A+S%3BLanza%2C+D+C&rft.aulast=Bolger&rft.aufirst=W&rft.date=1999-03-01&rft.volume=120&rft.issue=3&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Otolaryngology+and+head+and+neck+surgery&rft.issn=01945998&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Bacterial toxins: friends or foes? AN - 69722318; 10221874 AB - Many emerging and reemerging bacterial pathogens synthesize toxins that serve as primary virulence factors. We highlight seven bacterial toxins produced by well-established or newly emergent pathogenic microbes. These toxins, which affect eukaryotic cells by a variety of means, include Staphylococcus aureus alpha-toxin, Shiga toxin, cytotoxic necrotizing factor type 1, Escherichia coli heat-stable toxin, botulinum and tetanus neurotoxins, and S. aureus toxic-shock syndrome toxin. For each, we discuss the information available on its synthesis and structure, mode of action, and contribution to virulence. We also review the role certain toxins have played in unraveling signal pathways in eukaryotic cells and summarize the beneficial uses of toxins and toxoids. Our intent is to illustrate the importance of the analysis of bacterial toxins to both basic and applied sciences. JF - Emerging infectious diseases AU - Schmitt, C K AU - Meysick, K C AU - O'Brien, A D AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. PY - 1999 SP - 224 EP - 234 VL - 5 IS - 2 SN - 1080-6040, 1080-6040 KW - Bacterial Toxins KW - 0 KW - Bacterial Vaccines KW - Cytotoxins KW - Enterotoxins KW - Escherichia coli Proteins KW - Superantigens KW - heat stable toxin (E coli) KW - cytotoxic necrotizing factor type 1 KW - 106803-33-2 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - Animals KW - Bacterial Vaccines -- immunology KW - Cytotoxins -- toxicity KW - Botulinum Toxins -- toxicity KW - Humans KW - Superantigens -- pharmacology KW - Enterotoxins -- toxicity KW - Bacterial Toxins -- toxicity KW - Bacterial Toxins -- pharmacology KW - Bacterial Toxins -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69722318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+infectious+diseases&rft.atitle=Bacterial+toxins%3A+friends+or+foes%3F&rft.au=Schmitt%2C+C+K%3BMeysick%2C+K+C%3BO%27Brien%2C+A+D&rft.aulast=Schmitt&rft.aufirst=C&rft.date=1999-03-01&rft.volume=5&rft.issue=2&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Emerging+infectious+diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-05-13 N1 - Date created - 1999-05-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: MMWR Morb Mortal Wkly Rep. 1982 Nov 5;31(43):580, 585 [6817062] Eur Heart J. 1997 Dec;18 Suppl F:F28-35 [9447338] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] J Biol Chem. 1989 Jan 5;264(1):596-601 [2642481] J Clin Microbiol. 1990 Apr;28(4):694-9 [2185259] Mol Microbiol. 1991 Aug;5(8):1817-22 [1766367] Microbiol Rev. 1991 Dec;55(4):733-51 [1779933] Nature. 1992 Feb 20;355(6362):748-50 [1741063] Infect Immun. 1993 Nov;61(11):4909-14 [8406895] Vaccine. 1993 Sep;11(12):1179-84 [8256498] Trends Microbiol. 1994 Jan;2(1):20-4 [8162432] Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3814-8 [8170993] Int J Cancer. 1995 Apr 10;61(2):261-7 [7705957] Curr Top Microbiol Immunol. 1995;195:221-41 [8542755] Infect Immun. 1996 May;64(5):1569-76 [8613362] Infect Immun. 1996 Jun;64(6):1885-91 [8675283] Adv Exp Med Biol. 1996;391:131-54 [8726053] Cold Spring Harb Symp Quant Biol. 1995;60:329-35 [8824406] Science. 1996 Dec 13;274(5294):1859-66 [8943190] Immunol Invest. 1997 Jan-Feb;26(1-2):283-90 [9037631] Trends Microbiol. 1997 Apr;5(4):156-61 [9141190] Nature. 1997 Jun 12;387(6634):725-9 [9192900] Nature. 1997 Jun 12;387(6634):729-33 [9192901] JAMA. 1997 Jul 16;278(3):234-40 [9218672] Mol Microbiol. 1997 Jun;24(5):1061-70 [9220012] J Infect Dis. 1997 Aug;176(2):464-9 [9237713] Mol Membr Biol. 1997 Apr-Jun;14(2):45-64 [9253764] Mol Med. 1997 Jul;3(7):420-7 [9260154] Int Ophthalmol Clin. 1997 Summer;37(3):69-79 [9279643] Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11623-6 [9326660] Neurotoxicology. 1997;18(3):761-70 [9339823] Hosp Pract (1995). 1997 Nov 15;32(11):57-64, 69-73 [9385314] Biochim Biophys Acta. 1997 Oct 24;1333(2):C1-6 [9395287] Lancet. 1983 Mar 26;1(8326 Pt 1):702 [6132054] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical shift: the artifact and clinical tool revisited. AN - 69679565; 10194784 AB - The chemical shift phenomenon refers to the signal intensity alterations seen in magnetic resonance (MR) imaging that result from the inherent differences in the resonant frequencies of precessing protons. Chemical shift was first recognized as a misregistration artifact of image data. More recently, however, chemical shift has been recognized as a useful diagnostic tool. By exploiting inherent differences in resonant frequencies of lipid and water, fatty elements within tissue can be confirmed with dedicated chemical shift MR pulse sequences. Alternatively, the recognition of chemical shift on images obtained with standard MR pulse sequences may corroborate the diagnosis of lesions with substantial fatty elements. Chemical shift can aid in the diagnosis of lipid-containing lesions of the brain (lipoma, dermoid, and teratoma) or the body (adrenal adenoma, focal fat within the liver, and angiomyolipoma). In addition, chemical shift can be implemented to accentuate visceral margins (e.g., kidney and liver). JF - Radiographics : a review publication of the Radiological Society of North America, Inc AU - Hood, M N AU - Ho, V B AU - Smirniotopoulos, J G AU - Szumowski, J AD - Department of Radiology and Nuclear Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. PY - 1999 SP - 357 EP - 371 VL - 19 IS - 2 SN - 0271-5333, 0271-5333 KW - Lipids KW - 0 KW - Protons KW - Index Medicus KW - Physical Phenomena KW - Physics KW - Artifacts KW - Chemistry, Physical KW - Humans KW - Chemical Phenomena KW - Body Water KW - Magnetic Resonance Imaging -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69679565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiographics+%3A+a+review+publication+of+the+Radiological+Society+of+North+America%2C+Inc&rft.atitle=Chemical+shift%3A+the+artifact+and+clinical+tool+revisited.&rft.au=Hood%2C+M+N%3BHo%2C+V+B%3BSmirniotopoulos%2C+J+G%3BSzumowski%2C+J&rft.aulast=Hood&rft.aufirst=M&rft.date=1999-03-01&rft.volume=19&rft.issue=2&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Radiographics+%3A+a+review+publication+of+the+Radiological+Society+of+North+America%2C+Inc&rft.issn=02715333&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-15 N1 - Date created - 1999-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - External Democracy Promotion in Africa: Another False Start? AN - 61569608; 200002616 AB - Asserts that the wave of democratic elections in sub-Saharan Africa after 1989 was driven largely by external democracy promotion efforts, & it is for this reason that democratic regimes there are now crumbling. Examination of the interaction between external democracy promotion efforts & domestic structural variables leads to the conclusion that, while the international community can induce reform & implant electoral processes in Africa, it cannot force sustainable democratic governance in the absence of capitalist economies, civil societies, & bureaucratic states. Adapted from the source document. JF - Commonwealth and Comparative Politics AU - Lawson, Letitia AD - Naval Postgraduate School, Monterey, CA Y1 - 1999/03// PY - 1999 DA - March 1999 SP - 1 EP - 30 VL - 37 IS - 1 SN - 0306-3631, 0306-3631 KW - Economic Factors KW - Cultural Conflict KW - Geopolitics KW - Sub Saharan Africa KW - Cultural Imperialism KW - Africa KW - International Relations KW - Democracy KW - Political Change KW - Political Development KW - article KW - 0925: political sociology/interactions; sociology of political systems, politics, & power UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61569608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Commonwealth+and+Comparative+Politics&rft.atitle=External+Democracy+Promotion+in+Africa%3A+Another+False+Start%3F&rft.au=Lawson%2C+Letitia&rft.aulast=Lawson&rft.aufirst=Letitia&rft.date=1999-03-01&rft.volume=37&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Commonwealth+and+Comparative+Politics&rft.issn=03063631&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Democracy; Africa; Political Development; Political Change; Cultural Conflict; Cultural Imperialism; International Relations; Sub Saharan Africa; Economic Factors; Geopolitics ER - TY - JOUR T1 - Solutions to equations incorporating the effect of rate-limited contaminant mass transfer on vadose zone remediation by soil vapor extraction AN - 17266842; 4570230 AB - Soil vapor extraction (SVE) is a technique that is frequently used to remediate unsaturated soils in the vadose zone that are contaminated with volatile organic compounds. Laboratory research and field experience have demonstrated that rate-limited mass transfer of a contaminant from aquifer solids and soil water to the gas phase significantly impacts the efficacy and speed of the remediation. An exact analytical solution to equations describing SVE controlled by rate-limited mass transfer is presented. Processes modeled include contaminant advective-dispersive transport in a gas phase converging on an extraction well and rate-limited mass transfer of dissolved and sorbed contaminants into the gas phase, with the rate limitation modeled assuming first-order kinetics. In addition to the exact solution an approximate solution, as well as an exact solution for plug flow (no dispersion), is presented. These analytical solutions may be useful in verifying numerical codes that are being developed to model SVE of volatile organic compounds. JF - Water Resources Research AU - Huang, Junqi AU - Goltz, M N AD - Department of Engineering and Environmental Management, Graduate School of Engineering Air Force Institute of Technology, Wright-Patterson Air Force Base, Ohio, USA Y1 - 1999/03// PY - 1999 DA - Mar 1999 SP - 879 EP - 883 PB - American Geophysical Union VL - 35 IS - 3 SN - 0043-1397, 0043-1397 KW - soil vapor extraction KW - Water Resources Abstracts KW - Remediation KW - Soil contamination KW - Organic compounds KW - Mass transfer KW - Vadose water KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17266842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Research&rft.atitle=Solutions+to+equations+incorporating+the+effect+of+rate-limited+contaminant+mass+transfer+on+vadose+zone+remediation+by+soil+vapor+extraction&rft.au=Huang%2C+Junqi%3BGoltz%2C+M+N&rft.aulast=Huang&rft.aufirst=Junqi&rft.date=1999-03-01&rft.volume=35&rft.issue=3&rft.spage=879&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Research&rft.issn=00431397&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Remediation; Mass transfer; Organic compounds; Soil contamination; Vadose water ER - TY - JOUR T1 - Clinical Management of Carpal Tunnel Syndrome: A 12-Year Review of Outcomes AN - 17240717; 4524572 AB - Carpal tunnel syndrome (CTS) is a disorder frequently encountered by occupational health care specialists. The health care management of this disorder has involved a diverse set of clinical procedures. The present article is a review of the literature related to CTS with an emphasis on occupational-related CTS. MEDLINE, Cumulative Index to Nursing and Allied Health Literature, PsycLIT, and NIOSHTIC databases from 1985-1997 were searched for treatment outcome studies related to CTS. Treatments of interest included surgery, physical therapy, drug therapy, chiropractic treatment, biobehavioral interventions, and occupational rehabilitation. A systematic review of the effects of these interventions on symptoms, medical status, function, return to work, psychological well-being, and patient satisfaction was completed. Compared to other treatments, the majority of studies assessed the effects of surgical interventions. JF - American Journal of Industrial Medicine AU - Feuerstein, M AU - Burrell, L M AU - Miller, VI AU - Lincoln, A AU - Huang, G D AU - Berger, R AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA, mfeuerstein@mxb.usuhs.mil Y1 - 1999/03// PY - 1999 DA - Mar 1999 SP - 232 EP - 245 VL - 35 IS - 3 SN - 0271-3586, 0271-3586 KW - Carpal tunnel syndrome KW - reviews KW - Health & Safety Science Abstracts KW - Medical treatment KW - Human factors KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17240717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Clinical+Management+of+Carpal+Tunnel+Syndrome%3A+A+12-Year+Review+of+Outcomes&rft.au=Feuerstein%2C+M%3BBurrell%2C+L+M%3BMiller%2C+VI%3BLincoln%2C+A%3BHuang%2C+G+D%3BBerger%2C+R&rft.aulast=Feuerstein&rft.aufirst=M&rft.date=1999-03-01&rft.volume=35&rft.issue=3&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human factors; Occupational health; Medical treatment ER - TY - JOUR T1 - Aerobic and anaerobic microbiology of surgical-site infection following spinal fusion AN - 17226538; 4504034 AB - The aerobic and anaerobic microbiology of surgical-site infections (SSI) following spinal fusion was retrospectively studied. This was done by reviewing the clinical and microbiological records at the Naval Hospital in Bethesda, Md., from 1980 to 1992. Aspirates of pus from 25 infection sites showed bacterial growth. Aerobic bacteria only were recovered from 9 (36%) specimens, anaerobic bacteria only were recovered from 4 (16%), and mixed aerobic and anaerobic bacteria were recovered from 12 (48%). Sixty isolates were recovered: 38 aerobes (1.5 isolates per specimen) and 22 anaerobes (0.9 isolate per specimen). The predominant aerobes were Escherichia coli (n = 8) and Proteus sp. (n = 7). The predominant anaerobes were Bacteroides fragilis group (n = 9) and Peptostreptococcus sp. (n = 6) isolates. An increase in recovery of E. coli and B. fragilis was noted in patients with bowel or bladder incontinence. This study highlights the polymicrobial nature of SSI and the importance of anaerobic bacteria in SSI following spinal fusion. JF - Journal of Clinical Microbiology AU - Brook, I AU - Frazier, E H AD - P.O. Box 70412, Chevy Chase, MD 20813-0412, USA, BROOK@MX.AFRRI.USUHS.MIL Y1 - 1999/03// PY - 1999 DA - Mar 1999 SP - 841 EP - 843 VL - 37 IS - 3 SN - 0095-1137, 0095-1137 KW - USA, Maryland, Bethesda KW - etiology KW - Microbiology Abstracts B: Bacteriology KW - Bacteroides fragilis KW - Spine KW - Proteus KW - Surgery KW - Peptostreptococcus KW - Nosocomial infection KW - Escherichia coli KW - Anaerobic bacteria KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17226538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Aerobic+and+anaerobic+microbiology+of+surgical-site+infection+following+spinal+fusion&rft.au=Brook%2C+I%3BFrazier%2C+E+H&rft.aulast=Brook&rft.aufirst=I&rft.date=1999-03-01&rft.volume=37&rft.issue=3&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bacteroides fragilis; Escherichia coli; Peptostreptococcus; Proteus; Nosocomial infection; Surgery; Spine; Anaerobic bacteria ER - TY - JOUR T1 - Stress and Coping in Male and Female Health Care Providers during the Persian Gulf War: The USNS Comfort Hospital Ship AN - 17029838; 4610990 AB - The deployment of the USNS Comfort hospital ship during the Persian Gulf War provided an opportunity to examine the relationship of gender to stress and coping in health care providers exposed to wartime stressors. Just before the outbreak of Operation Desert Storm, medical personnel (N = 250) rated the stressfulness of current wartime experiences and the helpfulness of stress-reducing resources onboard ship in a combat theater. The responses of men and women were compared; to identify the dimensions of these responses, a principal factor analysis (orthogonal rotation) was performed. Generally, men and women ranked stressors and stress reducers similarly; women scored higher on the stress ratings. Two factors, similar for men and women, were identified in the stress ratings: fear of injury and trauma-related work demands. The dimensions of the stress reducers, however, were different for men and women. The findings support retrospective studies and suggest that different mechanisms of stress reduction may be operative even though men and women are performing the same activity. JF - Military Medicine AU - Slusarcick, AL AU - Ursano, R J AU - Fullerton, C S AU - Dinneen, M P AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA Y1 - 1999/03// PY - 1999 DA - Mar 1999 SP - 166 EP - 173 VL - 164 IS - 3 SN - 0026-4075, 0026-4075 KW - hospital ships KW - Persian Gulf KW - Health & Safety Science Abstracts KW - Stress KW - Military KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17029838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Medicine&rft.atitle=Stress+and+Coping+in+Male+and+Female+Health+Care+Providers+during+the+Persian+Gulf+War%3A+The+USNS+Comfort+Hospital+Ship&rft.au=Slusarcick%2C+AL%3BUrsano%2C+R+J%3BFullerton%2C+C+S%3BDinneen%2C+M+P&rft.aulast=Slusarcick&rft.aufirst=AL&rft.date=1999-03-01&rft.volume=164&rft.issue=3&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Military+Medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational health; Stress; Military ER - TY - JOUR T1 - Lactic acid does not directly activate hypothalamic-pituitary corticotroph function. AN - 69567993; 9933504 AB - The role that metabolic products play in regulating the hypothalamic-pituitary-adrenal (HPA) axis during strenuous exercise is speculative. This investigation examined the extent to which lactic acid, a major metabolite of anaerobic exercise, directly affects hypothalamic-pituitary function. Specifically, beta-endorphin secretion was measured from AtT-20 (D-16) mouse corticotroph tumor cells treated either acutely (15 min - 180 min) or chronically (1 day - 3 day) with physiologic levels of lactate (0. 5 x 10-3 M to 5 x 10-2 M) or lactate in combination with the corticotroph releasing factors: corticotroph releasing hormone (CRH), arginine vasopressin (AVP), norepinephrine and/or epinephrine. Findings with AtT-20 cell cultures were shown to be representative of responses in primary cultures of rat anterior pituitary. Lactic acid did not alter the spontaneous release of beta-endorphin by AtT-20 cells under either acute or chronic conditions. While CRH, norepinephrine, and epinephrine evoked significant increases in beta-endorphin release, lactate, in combination with these secretagogues did not alter their effects. Similarly, lactic acid failed to alter basal or stimulated release of beta-endorphin by primary cultures of rat anterior pituitary. The addition of lactate (3 x 103 M) to rat hypothalamic explants did, however, produce a modest but significant reduction in spontaneous CRH release, suggesting that lactate may facilitate the return to basal secretion following exercise. The present findings show that physiologic concentrations of lactate have no effect, either alone or in combination with other pituitary secretagogues, on corticotroph secretion. Whereas a physiologic action for lactate within the hypothalamus is possible, the present findings indicate that lactate is an inhibitor of CRH release. Thus, lactate does not appear to play a direct role in the profound activation of the HPA axis that occurs in response to strenuous exercise. JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) AU - Petrides, J S AU - Deuster, P A AU - Mueller, G P AD - Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1999/02// PY - 1999 DA - February 1999 SP - 100 EP - 105 VL - 220 IS - 2 SN - 0037-9727, 0037-9727 KW - Arginine Vasopressin KW - 113-79-1 KW - Lactic Acid KW - 33X04XA5AT KW - beta-Endorphin KW - 60617-12-1 KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Animals KW - Drug Interactions KW - Norepinephrine -- pharmacology KW - Physical Exertion -- physiology KW - Mice KW - Epinephrine -- administration & dosage KW - Corticotropin-Releasing Hormone -- pharmacology KW - Corticotropin-Releasing Hormone -- secretion KW - Rats KW - Arginine Vasopressin -- pharmacology KW - Rats, Sprague-Dawley KW - Epinephrine -- pharmacology KW - Arginine Vasopressin -- administration & dosage KW - beta-Endorphin -- secretion KW - Corticotropin-Releasing Hormone -- administration & dosage KW - Norepinephrine -- administration & dosage KW - Cell Line KW - Male KW - Hypothalamo-Hypophyseal System -- physiology KW - Hypothalamo-Hypophyseal System -- drug effects KW - Pituitary-Adrenal System -- drug effects KW - Lactic Acid -- administration & dosage KW - Pituitary-Adrenal System -- physiology KW - Lactic Acid -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69567993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine.+Society+for+Experimental+Biology+and+Medicine+%28New+York%2C+N.Y.%29&rft.atitle=Lactic+acid+does+not+directly+activate+hypothalamic-pituitary+corticotroph+function.&rft.au=Petrides%2C+J+S%3BDeuster%2C+P+A%3BMueller%2C+G+P&rft.aulast=Petrides&rft.aufirst=J&rft.date=1999-02-01&rft.volume=220&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Society+for+Experimental+Biology+and+Medicine.+Society+for+Experimental+Biology+and+Medicine+%28New+York%2C+N.Y.%29&rft.issn=00379727&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-25 N1 - Date created - 1999-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of Nicotine and Stress on Startle Amplitude and Sensory Gating Depend on Rat Strain and Sex AN - 17427070; 4647331 AB - We recently reported that 14 days of nicotine administration (12 mg/kg/day) reduced acoustic startle reflex amplitude and impaired prepulse inhibition (PPI) of startle in male and female Long-Evans rats (24). These findings contrasted with reports of nicotine-induced enhancement of startle and PPI in Sprague-Dawley (a different strain) male rats (2-4). The present experiment administered 0, 6, or 12 mg/kg/day nicotine via osmotic minipump for 14 days to 120 Sprague-Dawley rats (male and female) and to 120 Long-Evans rats (male and female) and examined ASR and PPI. Half of the subjects also were stressed by immobilization once each day to examine nicotine-stress interactions. Nicotine enhanced ASR and PPI responses of Sprague-Dawley rats but impaired these responses in Long-Evans rats, regardless of sex. Effects of stress were complex and depended on strain, sex, and drug dose. These findings indicate that effects of nicotine on measures of reactivity (ASR) and sensory gating (PPI) depend on genotype and that nicotine-stress interactions depend on genotype, sex, and nicotine dosage. JF - Pharmacology Biochemistry and Behavior AU - Faraday, M M AU - O'Donoghue, V A AU - Grunberg, N E AD - Department of Medical and Clinical Psychology, Uniformed Services, University of the Health Sciences (USUHS), 4301 Jones Bridge Road, Bethesda, MD 20814, USA Y1 - 1999/02// PY - 1999 DA - Feb 1999 SP - 273 EP - 284 VL - 62 IS - 2 SN - 0091-3057, 0091-3057 KW - rats KW - strains difference KW - dose-response effects KW - sensory gating KW - Toxicology Abstracts; Animal Behavior Abstracts KW - Startle response KW - Acoustic startle response KW - Nicotine KW - Gating KW - Stress KW - Sex differences KW - Y 25517:Mammals (excluding primates) KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17427070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Effects+of+Nicotine+and+Stress+on+Startle+Amplitude+and+Sensory+Gating+Depend+on+Rat+Strain+and+Sex&rft.au=Faraday%2C+M+M%3BO%27Donoghue%2C+V+A%3BGrunberg%2C+N+E&rft.aulast=Faraday&rft.aufirst=M&rft.date=1999-02-01&rft.volume=62&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/10.1016%2FS0091-3057%2898%2900159-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Nicotine; Stress; Acoustic startle response; Gating; Sex differences; Startle response DO - http://dx.doi.org/10.1016/S0091-3057(98)00159-2 ER - TY - JOUR T1 - An experiment using NSCAT winds in the numerical prediction of tropical mesoscale rainfall systems under the influence of terrain AN - 17267005; 4570999 AB - The rich mesoscale information in NSCAT winds over tropical coastal regions is used in numerical simulations of two June 1997 monsoonal cases occurring over Taiwan. It is shown that transient NSCAT mesoscale information over a localized area as small as 120 km x 240 km can result in significant improvement in the 24 h heavy rainfall forecast due to its effect on monsoonal convection and terrain effects. JF - Geophysical Research Letters AU - Chang, C-P AU - Lin, S-C AU - Liou, C-S AU - Liu, W T AD - Dept. of Meteorology, Naval Postgraduate School, Monterey, CA, USA Y1 - 1999/02// PY - 1999 DA - Feb 1999 SP - 311 EP - 314 VL - 26 IS - 3 SN - 0094-8276, 0094-8276 KW - Water Resources Abstracts KW - Rainfall KW - Forecasting KW - Wind KW - Monsoons KW - Coasts KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17267005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=An+experiment+using+NSCAT+winds+in+the+numerical+prediction+of+tropical+mesoscale+rainfall+systems+under+the+influence+of+terrain&rft.au=Chang%2C+C-P%3BLin%2C+S-C%3BLiou%2C+C-S%3BLiu%2C+W+T&rft.aulast=Chang&rft.aufirst=C-P&rft.date=1999-02-01&rft.volume=26&rft.issue=3&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Rainfall; Forecasting; Wind; Coasts; Monsoons ER - TY - JOUR T1 - Reproductive characteristics of migratory Golden Eagles in Denali National Park, Alaska AN - 17248355; 4527645 AB - We describe reproductive characteristics of Golden Eagles (Aquila chrysaetos) breeding in Denali National Park, Alaska during an entire snowshoe hare (Lepus americanus) cycle, 1988-1997. Data on nesting eagles were collected at 58 to 72 nesting areas annually using two aerial surveys. Surveys were conducted during the incubation period to determine occupancy and nesting activities and late in the nestling period to count nestlings and determine nesting success. Annual occupancy rates of nesting areas did not vary significantly, whereas laying rates, success rates, and mean brood size varied significantly over the study period. Fledgling production for the study population varied sevenfold during the ten-year period. Laying rates, mean brood size, and overall population productivity were significantly correlated with abundance of cyclic snowshoe hare and Willow Ptarmigan (Lagopus lagopus) populations. Reproductive rates of Golden Eagles in Denali were similar to those of Golden Eagles from other high latitude study areas in North America, but lower than for Golden Eagles from temperate zone study areas in North America. JF - Condor AU - McIntyre, CL AU - Adams, L G AD - National Park Service, 201 1st. Ave., Fairbanks, AK 99701, USA, carol_mcintyre@nps.gov Y1 - 1999/02// PY - 1999 DA - Feb 1999 SP - 115 EP - 123 VL - 101 IS - 1 SN - 0010-5422, 0010-5422 KW - Golden eagle KW - USA, Alaska KW - Animal Behavior Abstracts; Ecology Abstracts KW - Aquila chrysaetos KW - Reproduction KW - D 04671:Birds KW - Y 25426:Birds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17248355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Condor&rft.atitle=Reproductive+characteristics+of+migratory+Golden+Eagles+in+Denali+National+Park%2C+Alaska&rft.au=McIntyre%2C+CL%3BAdams%2C+L+G&rft.aulast=McIntyre&rft.aufirst=CL&rft.date=1999-02-01&rft.volume=101&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Condor&rft.issn=00105422&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Aquila chrysaetos; Reproduction ER - TY - JOUR T1 - A dynamic model of bioavailability of metals in constructed wetland sediments AN - 16130981; 4547573 AB - Constructed wetlands used for stormwater treatment accumulate metals primarily in their sediment. This sediment has the potential to produce toxic effects in benthic or aquatic organisms. Bioavailability of metals in sediments is directly linked to pore water metal activity. The mechanisms that influence pore water metal activity include physical, chemical, and biological processes. A system dynamics model was developed to represent these processes and the major influences affecting pore water metal activity in a treatment wetland receiving stormwater influent. The model structure and behavior were tested and validated using several system dynamics validation techniques. The model was run using metal specific parameter values typical of metals commonly found in stormwater runoff. Simulation results demonstrate that chemical processes of acid volatile sulfide (AVS) and organic carbon in binding metal in reduced sediments are the greatest influences in controlling metal bioavailability. The effect of bioturbation, as represented in the model, was negligible. The amount of organic carbon in the sediment plays the biggest role in controlling metal bioavailability in the long run. JF - Ecological Engineering AU - Wood, T S AU - Shelley, M L AD - AFIT/ENV, Graduate School of Engineering, Air Force Institute of Technology, 2950 P Street, Wright-Patterson AFB, OH 45433-7765, USA, mshelley@afit.af.mil Y1 - 1999/02// PY - 1999 DA - Feb 1999 SP - 231 EP - 252 PB - Elsevier Sciences B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 12 IS - 3-4 SN - 0925-8574, 0925-8574 KW - acid volatile sulfide KW - bioavailiability KW - constructed wetlands KW - mathematical models KW - Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources; Aqualine Abstracts; Pollution Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality KW - Pore water KW - Storm Runoff KW - Heavy metals KW - Organic carbon KW - Artificial Wetlands KW - Sulphides KW - Bioavailability KW - Water treatment KW - Stormwater runoff KW - Water pollution treatment KW - Sediment Contamination KW - Wetlands KW - Bioturbation KW - Metals KW - Sediment pollution KW - Sediment chemistry KW - Organic Carbon KW - Geochemistry KW - Sulfides KW - Simulation KW - Interstitial Water KW - Toxicity KW - Influents KW - Sediments KW - Model Studies KW - Bioaccumulation KW - Water Pollution Effects KW - Wastewater Treatment KW - AQ 00001:Water Resources and Supplies KW - Q5 08503:Characteristics, behavior and fate KW - Q1 08463:Habitat community studies KW - P 2000:FRESHWATER POLLUTION KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16130981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecological+Engineering&rft.atitle=A+dynamic+model+of+bioavailability+of+metals+in+constructed+wetland+sediments&rft.au=Wood%2C+T+S%3BShelley%2C+M+L&rft.aulast=Wood&rft.aufirst=T&rft.date=1999-02-01&rft.volume=12&rft.issue=3-4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Ecological+Engineering&rft.issn=09258574&rft_id=info:doi/10.1016%2FS0925-8574%2898%2900069-X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 1999-12-01 N1 - Last updated - 2014-05-05 N1 - SubjectsTermNotLitGenreText - Sulphides; Sediment chemistry; Bioavailability; Sediment pollution; Metals; Bioaccumulation; Stormwater runoff; Water pollution treatment; Organic carbon; Wetlands; Influents; Bioturbation; Pore water; Water treatment; Heavy metals; Sulfides; Simulation; Organic Carbon; Water Pollution Effects; Toxicity; Interstitial Water; Artificial Wetlands; Sediments; Model Studies; Storm Runoff; Geochemistry; Sediment Contamination; Wastewater Treatment DO - http://dx.doi.org/10.1016/S0925-8574(98)00069-X ER - TY - JOUR T1 - Nerve growth factor increases stimulus-evoked metabolic activity in acetylcholine-depleted barrel cortex. AN - 69958932; 10449063 AB - Lesions of the basal forebrain deplete the neocortex of cholinergic fibers. Acetylcholine depletion in the somatosensory cortex of rats results in reduced stimulus-evoked activity in response to whisker stimulation. Previous studies demonstrate that embryonic basal forebrain transplants improve functional activity toward normal. It is not clear if the activity increase is due to cholinergic replacement or other factors present in the graft. In this study, we examined the possibility that nerve growth factor (NGF), a neurotrophin known as a survival factor and a specific protectant for cholinergic basal forebrain neurons, can preserve basal forebrain cells after a lesion and restore functional activity in the somatosensory cortex. We report that NGF alone is capable of restoring functional activity in the barrel cortex of animals with basal forebrain lesions, while vehicle injections of saline do not alter activity. Both high (10 microg) and low (5 microg) doses of NGF unilaterally injected into the lateral ventricle improved stimulus-evoked functional activity during bilateral whisker stimulation. The mechanism of NGF action is not clear since the restoration of functional activity in cortex was not accompanied by increased cholinergic activity as detected by acetylcholinesterase fiber staining. NGF may act directly on cortical neurons, although its site of action is not well defined. JF - Somatosensory & motor research AU - Rahimi, O AU - Eslin, D E AU - Hill, G F AU - Juliano, S L AD - Department of Anatomy & Cell Biology, USUHS, Bethesda, MD 20814, USA. Y1 - 1999 PY - 1999 DA - 1999 SP - 151 EP - 162 VL - 16 IS - 2 SN - 0899-0220, 0899-0220 KW - Antimetabolites KW - 0 KW - Nerve Growth Factors KW - Deoxyglucose KW - 9G2MP84A8W KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Rats KW - Antimetabolites -- pharmacology KW - Animals KW - Rats, Sprague-Dawley KW - Prosencephalon -- physiology KW - Deoxyglucose -- pharmacology KW - Image Processing, Computer-Assisted KW - Female KW - Injections, Intraventricular KW - Somatosensory Cortex -- physiology KW - Nerve Growth Factors -- pharmacology KW - Acetylcholine -- deficiency KW - Somatosensory Cortex -- drug effects KW - Nerve Growth Factors -- administration & dosage KW - Somatosensory Cortex -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69958932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Somatosensory+%26+motor+research&rft.atitle=Nerve+growth+factor+increases+stimulus-evoked+metabolic+activity+in+acetylcholine-depleted+barrel+cortex.&rft.au=Rahimi%2C+O%3BEslin%2C+D+E%3BHill%2C+G+F%3BJuliano%2C+S+L&rft.aulast=Rahimi&rft.aufirst=O&rft.date=1999-01-01&rft.volume=16&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Somatosensory+%26+motor+research&rft.issn=08990220&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-10-04 N1 - Date created - 1999-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacologic causes of female incontinence. AN - 69850276; 10384972 AB - The etiology of female urinary incontinence is complex and multifactorial. Many medications have adverse effects on the lower urinary tract, including the promotion of incontinence in certain women. Medications may cause incontinence through three main mechanisms: decreased intraurethral pressure, increased intravesical pressure, and indirect effects on the lower urinary tract. Careful adjustments of a patient's medications based on a knowledge of pharmacologic mechanisms of action may restore continence in some women. JF - International urogynecology journal and pelvic floor dysfunction AU - Steele, A C AU - Kohli, N AU - Mallipeddi, P AU - Karram, M AD - Air Force Institute of Technology, Wright-Patterson AFB, USA. Y1 - 1999 PY - 1999 DA - 1999 SP - 106 EP - 110 VL - 10 IS - 2 KW - Index Medicus KW - Age Factors KW - Urinary Tract -- drug effects KW - Risk Factors KW - Humans KW - Aged KW - Middle Aged KW - Urodynamics -- drug effects KW - Urinary Tract -- innervation KW - Female KW - Medical History Taking KW - Urinary Incontinence -- physiopathology KW - Urinary Incontinence -- diagnosis KW - Urinary Incontinence -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69850276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+urogynecology+journal+and+pelvic+floor+dysfunction&rft.atitle=Pharmacologic+causes+of+female+incontinence.&rft.au=Steele%2C+A+C%3BKohli%2C+N%3BMallipeddi%2C+P%3BKarram%2C+M&rft.aulast=Steele&rft.aufirst=A&rft.date=1999-01-01&rft.volume=10&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=International+urogynecology+journal+and+pelvic+floor+dysfunction&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-29 N1 - Date created - 1999-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NPS 1506, a novel NMDA receptor antagonist and neuroprotectant. Review of preclinical and clinical studies. AN - 69432330; 10668449 AB - NPS 1506 is a moderate affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. NPS 1506 is neuroprotective in rodent models of ischemic stroke, hemorrhagic stroke, and head trauma, with a 2-hr window of opportunity. Neuroprotectant doses of NPS 1506 ranged from approximately 0.1-1.0 mg/kg, with peak plasma concentrations ranging from 8-80 ng/mL. Even at doses producing behavioral toxicity, NPS 1506 did not elicit MK-801-like behaviors, did not generalize to phencyclidine (PCP), and did not elicit neuronal vacuolization. In a Phase I study, intravenous (i.v.) doses of NPS 1506 from 5-100 mg were well tolerated and provided plasma concentrations in excess of those required for neuroprotection in rodents. Adverse events at the 100-mg dose included mild dizziness and lightheadedness, and mild to moderate ataxia. Neither PCP-like psychotomimetic effects nor cardiovascular effects were noted. The long plasma half-life of NPS 1506 (approximately 60 hr) suggests that a single i.v. dose will provide prolonged neuroprotection in humans. JF - Annals of the New York Academy of Sciences AU - Mueller, A L AU - Artman, L D AU - Balandrin, M F AU - Brady, E AU - Chien, Y AU - Delmar, E G AU - George, K AU - Kierstead, A AU - Marriott, T B AU - Moe, S T AU - Newman, M K AU - Raszkiewicz, J L AU - Sanguinetti, E L AU - van Wagenen, B C AU - Wells, D AD - NPS Pharmaceuticals, Inc., Salt Lake City, Utah 84108, USA. amueller@npsp.com Y1 - 1999 PY - 1999 DA - 1999 SP - 450 EP - 457 VL - 890 SN - 0077-8923, 0077-8923 KW - Fluorobenzenes KW - 0 KW - NPS 1506 KW - Neuroprotective Agents KW - Propylamines KW - Receptors, N-Methyl-D-Aspartate KW - 3,3-diphenylpropylamine KW - 5586-73-2 KW - Index Medicus KW - Stroke -- drug therapy KW - Animals KW - Brain Ischemia -- drug therapy KW - Humans KW - Adult KW - Clinical Trials as Topic KW - Propylamines -- pharmacology KW - Adolescent KW - Drug Evaluation, Preclinical KW - Male KW - Neuroprotective Agents -- blood KW - Fluorobenzenes -- pharmacology KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Learning -- drug effects KW - Fluorobenzenes -- therapeutic use KW - Neuroprotective Agents -- therapeutic use KW - Fluorobenzenes -- blood KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69432330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=NPS+1506%2C+a+novel+NMDA+receptor+antagonist+and+neuroprotectant.+Review+of+preclinical+and+clinical+studies.&rft.au=Mueller%2C+A+L%3BArtman%2C+L+D%3BBalandrin%2C+M+F%3BBrady%2C+E%3BChien%2C+Y%3BDelmar%2C+E+G%3BGeorge%2C+K%3BKierstead%2C+A%3BMarriott%2C+T+B%3BMoe%2C+S+T%3BNewman%2C+M+K%3BRaszkiewicz%2C+J+L%3BSanguinetti%2C+E+L%3Bvan+Wagenen%2C+B+C%3BWells%2C+D&rft.aulast=Mueller&rft.aufirst=A&rft.date=1999-01-01&rft.volume=890&rft.issue=&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-15 N1 - Date created - 2000-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term desorption of trichloroethylene from flint clay using multiplexed optical detection AN - 52359441; 2000-037920 JF - Environmental Pollution (1987) AU - Stager, M P AU - Perram, G P Y1 - 1999 PY - 1999 DA - 1999 SP - 397 EP - 400 PB - Elsevier, Barking VL - 104 IS - 3 SN - 0269-7491, 0269-7491 KW - soils KW - chlorinated hydrocarbons KW - desorption KW - monitoring KW - detection limit KW - pollutants KW - pollution KW - techniques KW - bonding KW - powder method KW - volatiles KW - organic compounds KW - infrared spectroscopy KW - optical properties KW - transport KW - volatile organic compounds KW - halogenated hydrocarbons KW - trichloroethylene KW - spectroscopy KW - kinetics KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52359441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Pollution+%281987%29&rft.atitle=Long-term+desorption+of+trichloroethylene+from+flint+clay+using+multiplexed+optical+detection&rft.au=Stager%2C+M+P%3BPerram%2C+G+P&rft.aulast=Stager&rft.aufirst=M&rft.date=1999-01-01&rft.volume=104&rft.issue=3&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Environmental+Pollution+%281987%29&rft.issn=02697491&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/02697491 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 14 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - ENVPAF N1 - SubjectsTermNotLitGenreText - bonding; chlorinated hydrocarbons; desorption; detection limit; halogenated hydrocarbons; infrared spectroscopy; kinetics; monitoring; optical properties; organic compounds; pollutants; pollution; powder method; soils; spectroscopy; techniques; transport; trichloroethylene; volatile organic compounds; volatiles ER - TY - JOUR T1 - Sand bars at Duck, NC, U.S.A.; observations and model predictions AN - 52288557; 2001-001462 AB - Wave and bathymetry data recorded for 18 years (1980-1998) by the Field Research Facility (FRF) of the US Corps of Engineers at Duck, NC are analysed. These observations are compared with predictions from a wave-seabed interaction model (Boczar-Karakiewicz et al. 1995 and 1998) to better understand bar dynamics in a wave-dominated coastal environment. JF - Coastal Sediments: Proceedings of the ... International Symposium on Coastal Engineering and Science of Coastal Sediment Processes AU - Romanczyk, W AU - Boczar-Karakiewicz, B AU - Thornton, Edward B AU - Bona, J L A2 - Kraus, Nicholas C. A2 - McDougal, William G. Y1 - 1999 PY - 1999 DA - 1999 SP - 491 EP - 504 PB - American Society of Civil Engineers, New York, NY VL - 4, Vol. 1 KW - United States KW - sand KW - shore features KW - clastic sediments KW - sedimentation KW - bars KW - Duck North Carolina KW - Dare County North Carolina KW - models KW - North Carolina KW - sediments KW - coastal environment KW - storms KW - geomorphology KW - bathymetry KW - coastal sedimentation KW - Atlantic Coastal Plain KW - 23:Geomorphology KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52288557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Coastal+Sediments%3A+Proceedings+of+the+...+International+Symposium+on+Coastal+Engineering+and+Science+of+Coastal+Sediment+Processes&rft.atitle=Sand+bars+at+Duck%2C+NC%2C+U.S.A.%3B+observations+and+model+predictions&rft.au=Romanczyk%2C+W%3BBoczar-Karakiewicz%2C+B%3BThornton%2C+Edward+B%3BBona%2C+J+L&rft.aulast=Romanczyk&rft.aufirst=W&rft.date=1999-01-01&rft.volume=4%2C+Vol.+1&rft.issue=&rft.spage=491&rft.isbn=0784404364&rft.btitle=&rft.title=Coastal+Sediments%3A+Proceedings+of+the+...+International+Symposium+on+Coastal+Engineering+and+Science+of+Coastal+Sediment+Processes&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 4th international symposium on Coastal engineering and science of coastal sediment processes; Scales of coastal sediment motion and geomorphic change N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 6 N1 - PubXState - NY N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #05350 N1 - SubjectsTermNotLitGenreText - Atlantic Coastal Plain; bars; bathymetry; clastic sediments; coastal environment; coastal sedimentation; Dare County North Carolina; Duck North Carolina; geomorphology; models; North Carolina; sand; sedimentation; sediments; shore features; storms; United States ER - TY - JOUR T1 - Sediment fluxes above a mobile sandy bed in the nearshore AN - 52288456; 2001-001444 AB - Observations of sediment concentration and three component velocity profiles near the bed were made with a small scale coherent acoustic doppler profiler during the SandyDuck experiment. Vertical profiles of both sediment concentration and velocity from coincident 1.7 cm high sample volumes are used to estimate suspended sediment concentrations and sediment flux timeseries for stations over a flat offshore bed and in the trough of a mega-ripple. Differences in mean profiles and temporal intermittency of the suspension events are discussed. JF - Coastal Sediments: Proceedings of the ... International Symposium on Coastal Engineering and Science of Coastal Sediment Processes AU - Stanton, Timothy P AU - Thornton, Edward B A2 - Kraus, Nicholas C. A2 - McDougal, William G. Y1 - 1999 PY - 1999 DA - 1999 SP - 241 EP - 252 PB - American Society of Civil Engineers, New York, NY VL - 4, Vol. 1 KW - sand KW - sediment transport KW - clastic sediments KW - sedimentation KW - nearshore sedimentation KW - techniques KW - altimetry KW - nearshore environment KW - bedforms KW - measurement KW - morphology KW - sediments KW - bathymetry KW - 06A:Sedimentary petrology KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52288456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Coastal+Sediments%3A+Proceedings+of+the+...+International+Symposium+on+Coastal+Engineering+and+Science+of+Coastal+Sediment+Processes&rft.atitle=Sediment+fluxes+above+a+mobile+sandy+bed+in+the+nearshore&rft.au=Stanton%2C+Timothy+P%3BThornton%2C+Edward+B&rft.aulast=Stanton&rft.aufirst=Timothy&rft.date=1999-01-01&rft.volume=4%2C+Vol.+1&rft.issue=&rft.spage=241&rft.isbn=0784404364&rft.btitle=&rft.title=Coastal+Sediments%3A+Proceedings+of+the+...+International+Symposium+on+Coastal+Engineering+and+Science+of+Coastal+Sediment+Processes&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 4th international symposium on Coastal engineering and science of coastal sediment processes; Scales of coastal sediment motion and geomorphic change N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 5 N1 - PubXState - NY N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #05350 N1 - SubjectsTermNotLitGenreText - altimetry; bathymetry; bedforms; clastic sediments; measurement; morphology; nearshore environment; nearshore sedimentation; sand; sediment transport; sedimentation; sediments; techniques ER - TY - JOUR T1 - Vertical and horizontal coherence length scales of suspended sediments AN - 52283817; 2001-001443 AB - Suspended sediments were measured across a barred beach during the SandyDuck experiment. The vertical profiles of suspended sediments were measured acoustically, and the vertical coherence length scale was found to be an order of magnitude greater than the wave boundary layer. The cross-shore horizontal coherence length scale of suspended sediment was determined using a two meter lagged array of six optical backscatter sensors. The horizontal coherence length scale, defined as the e-folding scale of the exponentially decreasing horizontal coherence, was approximately 0.8 times the rms wave orbital excursion length for all cross-shore stations. Both the vertical and horizontal coherence length scales are longest for infragravity waves and decrease with increasing frequency. JF - Coastal Sediments: Proceedings of the ... International Symposium on Coastal Engineering and Science of Coastal Sediment Processes AU - Huck, Michael P AU - Thornton, Edward B AU - Stanton, Timothy P A2 - Kraus, Nicholas C. A2 - McDougal, William G. Y1 - 1999 PY - 1999 DA - 1999 SP - 225 EP - 240 PB - American Society of Civil Engineers, New York, NY VL - 4, Vol. 1 KW - waves KW - statistical analysis KW - sedimentation KW - data processing KW - bars KW - suspension KW - suspended materials KW - marine sedimentation KW - beaches KW - bottom features KW - sediments KW - coastal sedimentation KW - 06A:Sedimentary petrology KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52283817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Coastal+Sediments%3A+Proceedings+of+the+...+International+Symposium+on+Coastal+Engineering+and+Science+of+Coastal+Sediment+Processes&rft.atitle=Vertical+and+horizontal+coherence+length+scales+of+suspended+sediments&rft.au=Huck%2C+Michael+P%3BThornton%2C+Edward+B%3BStanton%2C+Timothy+P&rft.aulast=Huck&rft.aufirst=Michael&rft.date=1999-01-01&rft.volume=4%2C+Vol.+1&rft.issue=&rft.spage=225&rft.isbn=0784404364&rft.btitle=&rft.title=Coastal+Sediments%3A+Proceedings+of+the+...+International+Symposium+on+Coastal+Engineering+and+Science+of+Coastal+Sediment+Processes&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 4th international symposium on Coastal engineering and science of coastal sediment processes; Scales of coastal sediment motion and geomorphic change N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 10 N1 - PubXState - NY N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #05350 N1 - SubjectsTermNotLitGenreText - bars; beaches; bottom features; coastal sedimentation; data processing; marine sedimentation; sedimentation; sediments; statistical analysis; suspended materials; suspension; waves ER - TY - JOUR T1 - Dam removal and channel restoration at Fossil Butte National Monument AN - 50903161; 2001-024068 AB - This paper describes the demolition of two stockpond dams at Fossil Butte National Monument and restoration of associated gullies. The project was part of a plan to remove four man-made stockponds from the Chicken Creek watershed to return the drainage to a properly functioning hydrologic condition and mimic the natural channel geometry. Other human activities have affected the stability of Chicken Creek and its tributaries, including construction of the Oregon Shortline Railroad, domestic livestock grazing, road building, and agricultural activities. Although Chicken Creek is still responding to base level changes caused by railroad construction, most of its headcuts are small and relatively stable. Since the elimination of livestock grazing in 1989 some gullies have begun to heal. The restoration goal was to initiate a trend towards a stable, naturally functioning ecosystem. We describe an innovative approach to gully restoration, discuss project effectiveness, and make suggestions for improvement in project implementation. JF - Technical Publication Series - American Water Resources Association AU - Kyte, Clayton R AU - Santucci, Vincent L AU - Inglis, Richard R, Jr AU - Olsen, Darren S AU - Potyondy, John P Y1 - 1999 PY - 1999 DA - 1999 SP - 309 EP - 316 PB - AWRA - American Water Resources Association, Bethesda, MD VL - 99-3 SN - 0731-9789, 0731-9789 KW - United States KW - hydrology KW - Fossil Butte National Monument KW - reclamation KW - rivers and streams KW - watersheds KW - Wasatch Formation KW - Paleogene KW - southwestern Wyoming KW - Cenozoic KW - Wyoming KW - Tertiary KW - riparian environment KW - Chicken Creek KW - dams KW - streams KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50903161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Publication+Series+-+American+Water+Resources+Association&rft.atitle=Dam+removal+and+channel+restoration+at+Fossil+Butte+National+Monument&rft.au=Kyte%2C+Clayton+R%3BSantucci%2C+Vincent+L%3BInglis%2C+Richard+R%2C+Jr%3BOlsen%2C+Darren+S%3BPotyondy%2C+John+P&rft.aulast=Kyte&rft.aufirst=Clayton&rft.date=1999-01-01&rft.volume=99-3&rft.issue=&rft.spage=309&rft.isbn=1882132475&rft.btitle=&rft.title=Technical+Publication+Series+-+American+Water+Resources+Association&rft.issn=07319789&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Water Resources Association summer specialty conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 7 N1 - PubXState - MD N1 - Document feature - sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Cenozoic; Chicken Creek; dams; Fossil Butte National Monument; hydrology; Paleogene; reclamation; riparian environment; rivers and streams; southwestern Wyoming; streams; Tertiary; United States; Wasatch Formation; watersheds; Wyoming ER - TY - JOUR T1 - Biodegradability and microbial toxicity of aircraft fuel system icing inhibitors AN - 19423322; 4573527 AB - In a pollution prevention and chemical substitution effort, the U.S. Air Force and Navy formed a joint initiative to find safer, more environmentally acceptable jet fuel system icing inhibitors (FSII) for military aircraft. Standard biochemical oxygen demand (BOD) analysis and variations of the BOD procedure were used as simple screening tools to evaluate the potential for aquatic biodegradation and microbial toxicity of proposed FSIIs. This laboratory evaluation of biological properties allows prediction of the biotreatability of the chemicals in wastewater treatment plants, and their potential application as biocides at higher concentrations. The current FSII, diethylene glycol monomethyl ether (DiEGME) was evaluated along with two new candidate compounds, dipropylene glycol and glycerol formal. At a low concentration (3.5 mg/L), DiEGME exerted a BOD sub(5) of about 27% of theoretical oxygen demand. Test concentrations of greater than or equal to 7 mg/L had decreasing oxygen consumption rate and extent, typical of a material with potential aquatic microbial toxicity. Dipropylene glycol began to moderately degrade only after more than 3 weeks exposure to microorganisms obtained from raw sewage. Glycerol formal showed no signs of biodegradation during a 5-week test period. In a simple microbial toxicity test DiEGME was most toxic, dipropylene glycol was moderately toxic, and glycerol formal showed little toxicity. At low concentrations (7 mg/L), none of the chemicals significantly inhibited microbial activity (P=0.34). JF - Environmental Toxicology AU - Meshako, CE AU - Bleckmann, CA AU - Goltz, M N AD - Department of Engineering and Environmental Management, Air Force Institute of Technology, Wright-Patterson Air Force Base, Ohio 45433-7765, USA Y1 - 1999 PY - 1999 DA - 1999 SP - 383 EP - 390 PB - John Wiley & Sons, Inc. VL - 14 IS - 4 SN - 1520-4081, 1520-4081 KW - diethylene glycol monomethyl ether KW - dipropylene glycol KW - glycerol formal KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Aqualine Abstracts; Toxicology Abstracts; Water Resources Abstracts; Pollution Abstracts KW - Fuels KW - Navy KW - Ethers KW - Biocides KW - Fuel KW - Oxygen consumption KW - Micro-organisms KW - Ice KW - Pesticides (see also Bactericides, Weedkillers) KW - Oxygen demand (Biochemical) KW - Microbial activity KW - Water pollution control KW - Sewage KW - Microorganisms KW - Biochemical oxygen demand KW - Toxicity (see also Lethal limits) KW - Toxicity testing KW - Chemicals KW - Biodegradation KW - Wastewater treatment KW - Aircraft KW - Water Pollution Prevention KW - deicing KW - Deicers KW - Toxicity KW - Biochemical Oxygen Demand KW - Biodegradability KW - Joints KW - Biodegradation (see also Biological oxidation) KW - Diethylene glycol KW - Glycerol KW - X 24151:Acute exposure KW - W 30950:Waste Treatment & Pollution Clean-up KW - A 01450:Environmental Pollution & Waste Treatment KW - SW 3070:Water quality control KW - AQ 00002:Water Quality KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19423322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology&rft.atitle=Biodegradability+and+microbial+toxicity+of+aircraft+fuel+system+icing+inhibitors&rft.au=Meshako%2C+CE%3BBleckmann%2C+CA%3BGoltz%2C+M+N&rft.aulast=Meshako&rft.aufirst=CE&rft.date=1999-01-01&rft.volume=14&rft.issue=4&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology&rft.issn=15204081&rft_id=info:doi/10.1002%2F%28SICI%291522-7278%281999%2914%3A43.0.CO%3B2-M LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 1999-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Oxygen consumption; Biodegradation; Fuels; Toxicity; Wastewater treatment; Biodegradability; Joints; Diethylene glycol; Glycerol; Sewage; Aircraft; Microorganisms; Navy; Biochemical oxygen demand; Biocides; Ethers; Toxicity testing; Chemicals; Ice; Microbial activity; Water pollution control; Micro-organisms; Biodegradation (see also Biological oxidation); Pesticides (see also Bactericides, Weedkillers); Oxygen demand (Biochemical); Toxicity (see also Lethal limits); deicing; Water Pollution Prevention; Biochemical Oxygen Demand; Fuel; Deicers DO - http://dx.doi.org/10.1002/(SICI)1522-7278(1999)14:4<383::AID-TOX2>3.0.CO;2-M ER - TY - JOUR T1 - Why Don't Parks and Sanctuaries Protect Marine Fish Too? AN - 18009244; 4695064 AB - Many people believe that marine wilderness--i.e., areas of the sea where human influences are minimized and no extractive uses are allowed--protects biodiversity, restores and sustains fisheries, provides insurance for management errors, and produces tourism industries. In spite of the apparent benefits, and in stark contrast to the proliferation of wilderness designations in the terrestrial environment, very little marine wilderness has been designated worldwide. Marine protected areas (MPAs) abound, but we afford few portions of the sea enough protection from fisheries harvest and other extractive activities to function as wilderness. Why?. JF - George Wright Forum AU - Davis, GE AD - U. S. National Park Service, Channel Islands National Park, 1901 Spinnaker Drive, Ventura, California 93001, USA, gary_davis@nps.gov Y1 - 1999 PY - 1999 DA - 1999 SP - 88 EP - 96 VL - 16 IS - 2 SN - 0732-4715, 0732-4715 KW - ASFA 3: Aquatic Pollution & Environmental Quality KW - Marine KW - INE, USA, California, Channel Is. KW - World Oceans KW - Fishery regulations KW - Fishery resources KW - Pisces KW - Marine fish KW - Protected resources KW - Fishery management KW - Marine environment KW - Marine parks KW - Ecosystem management KW - Nature conservation KW - Sanctuaries KW - Q5 08523:Conservation, wildlife management and recreation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18009244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=George+Wright+Forum&rft.atitle=Why+Don%27t+Parks+and+Sanctuaries+Protect+Marine+Fish+Too%3F&rft.au=Davis%2C+GE&rft.aulast=Davis&rft.aufirst=GE&rft.date=1999-01-01&rft.volume=16&rft.issue=2&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=George+Wright+Forum&rft.issn=07324715&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Marine fish; Protected resources; Fishery management; Marine environment; Nature conservation; Ecosystem management; Marine parks; Fishery regulations; Sanctuaries; Fishery resources; Pisces; INE, USA, California, Channel Is.; World Oceans; Marine ER - TY - JOUR T1 - Analysis of structure activity relationships for LPS-mimetic activities of taxane analogs in murine macrophages AN - 17516381; 4703225 AB - The anti-tumor agent, paclitaxel (active ingredient of Taxol super( registered )), is best recognized for its ability to bind to microtubules and to block cell division. However, it has more recently been demonstrated to mimic the varied effects of bacterial lipopolysaccharide (LPS) in murine macrophages, actions that appear to be dissociable from its well-characterized beta -tubulin binding capacity. Secretion of tumor necrosis factor alpha (TNF alpha ) and induction of TNF alpha gene expression were assessed in macrophages treated with paclitaxel analogs. Two structural modifications resulted in elevated TNF alpha mRNA and protein secretion: (i) the presence of a cyclopropane carboxylate ester at C-4 rather than an acetate; or (ii) deoxygenation of the C-7 position. Certain modifications essentially eliminated activity: derivatization of the side chain 2' hydroxy group to form an ethyl carbonate, the presence of a benzoate at C-4 rather than an acetate, or de-acetylization to leave a free hydroxy group at the C-10 position. Substitution of the phenyl group at the 3' carbon position of the side chain with a 2-furyl group or the presence of a 2- or 3-pyridine carboxylate moiety at C-2 rather than a benzoate also resulted in a significant reduction in TNF alpha . These structure-activity relationships can be distinguished from those that affect the cytotoxic effects of paclitaxel which are attributable to its microtubule binding activity. JF - Journal of Endotoxin Research AU - Perera, P-Y AU - Kadow, J F AU - Fairchild, C R AU - Johnston, KA AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA, vogel@bob.usuf2.usuhs.mil Y1 - 1999 PY - 1999 DA - 1999 SP - 261 EP - 267 VL - 5 IS - 5-6 SN - 0968-0519, 0968-0519 KW - structure-activity relationships KW - mice KW - analogs KW - taxane KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Tumor necrosis factor KW - Lipopolysaccharides KW - Antineoplastic drugs KW - X 24117:Biochemistry KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17516381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=Analysis+of+structure+activity+relationships+for+LPS-mimetic+activities+of+taxane+analogs+in+murine+macrophages&rft.au=Perera%2C+P-Y%3BKadow%2C+J+F%3BFairchild%2C+C+R%3BJohnston%2C+KA%3BVogel%2C+S+N&rft.aulast=Perera&rft.aufirst=P-Y&rft.date=1999-01-01&rft.volume=5&rft.issue=5-6&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Antineoplastic drugs; Macrophages; Tumor necrosis factor; Lipopolysaccharides ER - TY - JOUR T1 - Identification of CD18 as a novel Taxol binding/signaling protein in murine macrophage membranes AN - 17399549; 4628206 AB - The anti-tumor agent, Taxol, is a potent LPS mimetic in murine macrophages, an activity that is dissociable from its well-characterized anti-mitotic activity which is mediated by microtubule hyperstabilization. A photoactivatable Taxol analog was used to identify components of a putative, shared LPS signaling apparatus in murine macrophage membranes. We report here that CD18, the beta chain of the beta sub(2)-integrin, Mac-1, represents a major Taxol binding protein in murine macrophages. JF - Journal of Endotoxin Research AU - Vogel, S N AU - Bhat, N AU - Carboni, J M AU - Mayadas, T N AU - Blanco, J AU - Perera, P-Y AU - Golenbock, D T AD - Department of Microbiology and Immunology, USUHS, Bethesda, MD 20814, USA Y1 - 1999 PY - 1999 DA - 1999 SP - 170 EP - 173 VL - 5 IS - 3 SN - 0968-0519, 0968-0519 KW - CD18 antigen KW - binding KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Membranes KW - Antitumor agents KW - Proteins KW - Lipopolysaccharides KW - Taxol KW - X 24171:Microbial KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17399549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=Identification+of+CD18+as+a+novel+Taxol+binding%2Fsignaling+protein+in+murine+macrophage+membranes&rft.au=Vogel%2C+S+N%3BBhat%2C+N%3BCarboni%2C+J+M%3BMayadas%2C+T+N%3BBlanco%2C+J%3BPerera%2C+P-Y%3BGolenbock%2C+D+T&rft.aulast=Vogel&rft.aufirst=S&rft.date=1999-01-01&rft.volume=5&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lipopolysaccharides; Taxol; Antitumor agents; Macrophages; Membranes; Proteins ER - TY - JOUR T1 - A mechanistic simulation model of a constructed wetland designed to remove organic matter from stormwater runoff AN - 17379607; 4609150 AB - A numerical simulation model is presented for a surface-water-fed constructed wetland with a pretreatment detention pool for flow control. The model combines system hydrology with processes thought to be important in the removal and treatment of low levels of dissolved organic matter typical of stormwater runoff. A mechanistic system dynamics approach is used to explore system behavior under reasonable ranges of values of environmental conditions and potentially important design parameters. Generalized results are presented, giving insight into the importance or unimportance of such factors in influencing treatment efficiency of organic matter. Results demonstrate the importance of factors which control organic loading and available surface area for biofilm development, and the relative unimportance of factors controlling flow velocity, for example. Wetland surface area is an important design parameter with competing effects requiring optimization. Model equations are presented and can be employed in numerical simulation to study optimum design strategies for a specific location with defined environmental conditions. JF - Journal of Environmental Systems AU - Shelley, M L AU - Mudgett, LA AD - Air Force Institute of Technology, Wright Patterson AFB Y1 - 1999 PY - 1999 DA - 1999 SP - 33 EP - 54 VL - 27 IS - 1 SN - 0047-2433, 0047-2433 KW - simulation KW - ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts; Water Resources Abstracts KW - Bioremediation KW - Storm Runoff KW - Detention Reservoirs KW - Organic Loading KW - Artificial Wetlands KW - Wastewater treatment KW - Organic Matter KW - Stormwater runoff KW - Hydrology KW - Wetlands KW - Biofilms KW - Organic matter KW - Simulation KW - Dynamics KW - Model Studies KW - Numerical Analysis KW - Behavior KW - Flow Control KW - Environmental conditions KW - Optimization KW - SW 3040:Wastewater treatment processes KW - P 2000:FRESHWATER POLLUTION KW - Q5 08502:Methods and instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17379607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Systems&rft.atitle=A+mechanistic+simulation+model+of+a+constructed+wetland+designed+to+remove+organic+matter+from+stormwater+runoff&rft.au=Shelley%2C+M+L%3BMudgett%2C+LA&rft.aulast=Shelley&rft.aufirst=M&rft.date=1999-01-01&rft.volume=27&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Systems&rft.issn=00472433&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Bioremediation; Stormwater runoff; Organic matter; Wetlands; Wastewater treatment; Simulation; Hydrology; Biofilms; Environmental conditions; Numerical Analysis; Storm Runoff; Behavior; Organic Matter; Detention Reservoirs; Organic Loading; Flow Control; Artificial Wetlands; Optimization; Dynamics; Model Studies ER - TY - JOUR T1 - Establishment of unipolar localization of IcsA in Shigella flexneri 2a is not dependent on virulence plasmid determinants AN - 17162719; 4456710 AB - Unipolar localization of IcsA on the surface of Shigella flexneri is required for efficient formation of actin tails and protrusions in infected eucaryotic cells. Lipopolysaccharide (LPS) mutations have been demonstrated to affect either the establishment or the maintenance of IcsA in a unipolar location, although the mechanism is unknown. In order to analyze the contribution of virulence plasmid determinants on the unipolar localization of IcsA, we examined the localization of IcsA expressed from a cloned plasmid copy in two different genetic backgrounds. The localization of IcsA was first examined in a virulence plasmid-cured derivative of the wild-type S. flexneri 2a isolate 2457T. This approach examined the contribution of virulence plasmid-borne factors, including the previously identified virulence plasmid-borne protease that is responsible for cleaving IcsA in the outer membrane and releasing the 95-kDa secreted form from the cell surface. IcsA localization in a related but nonpathogenic Escherichia coli strain expressing LPS of the O8 serotype was also examined. IcsA surface presentation in both of these genetic backgrounds continued to be unipolar, demonstrating that virulence plasmid-borne determinants are not responsible for unipolar localization of IcsA. The unipolar localization of IcsA in the E. coli background suggests that a common pathway that allows IcsA to be spatially restricted to one pole on the bacterial cell surface exists in Shigella and E. coli. JF - Infection and Immunity AU - Sandlin, R C AU - Maurelli, A T AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA, AMAURELLI@MXB.USUHS.MIL Y1 - 1999/01// PY - 1999 DA - Jan 1999 SP - 350 EP - 356 VL - 67 IS - 1 SN - 0019-9567, 0019-9567 KW - IcsA protein KW - Proteinase KW - Microbiology Abstracts B: Bacteriology KW - Virulence KW - Gene expression KW - Antigenic determinants KW - Shigella flexneri KW - Outer membranes KW - Escherichia coli KW - Plasmids KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17162719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Establishment+of+unipolar+localization+of+IcsA+in+Shigella+flexneri+2a+is+not+dependent+on+virulence+plasmid+determinants&rft.au=Sandlin%2C+R+C%3BMaurelli%2C+A+T&rft.aulast=Sandlin&rft.aufirst=R&rft.date=1999-01-01&rft.volume=67&rft.issue=1&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Shigella flexneri; Plasmids; Gene expression; Virulence; Outer membranes; Antigenic determinants ER - TY - JOUR T1 - Patterns of human disturbance and response by small mammals and birds in chaparral near urban development AN - 860392702; 13880113 AB - We report on the extent of disturbance (including habitat alteration and road and trail proliferation) in chaparral near urban development and analyze the effects of disturbance on small mammal and resident bird species. Disturbance patterns were evaluated in a 6700 ha study area in southern California: effects on mammals and birds were investigated by analyzing relationships between vegetation structure and animal species richness and abundance. Disturbance was prevalent throughout the study area and included extensive human-altered habitat (from past human activities such as vegetation clearing, human-caused fires, refuse dumping, and vegetation trampling) and 157 km of roads and trails. A nonsignificant trend was found between human-altered habitat and proximity to development, but human-altered habitat was significantly associated with roadway proximity. Trails were also more frequent near urban development and roads. Small mammals responded strongly to disturbance-related vegetation changes, while birds showed little or no response. Mammals endemic to chaparral vegetation were less diverse and abundant in disturbed sites, whereas disturbance-associated species increased in abundance. Close proximity of urban development to natural areas resulted in alteration of natural habitat and proliferation of roads and trails. Variation in life history traits between birds and mammals may affect response to disturbance and influence persistence if disturbance continues. Conservation efforts must recognize the potential for habitat damage and associated declines in native animal species caused by disturbance near urbanization and implement strategies to reduce these threats. JF - Urban Ecosystems AU - Sauvajot, Raymond M AU - Buechner, Marybeth AU - Kamradt, Denise A AU - Schonewald, Christine M AD - Division of Environmental Studies, University of California, Davis, CA, 95616, USA; . ray_sauvajot[AT]nps.gov Y1 - 1998/12// PY - 1998 DA - Dec 1998 SP - 279 EP - 297 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 2 IS - 4 SN - 1083-8155, 1083-8155 KW - Environment Abstracts; Sustainability Science Abstracts; Ecology Abstracts KW - mammals KW - Fires KW - disturbance KW - Urbanization KW - Abundance KW - chaparral KW - life history KW - Vegetation KW - Development KW - Habitat KW - Solid wastes KW - Trampling KW - Aves KW - Urban planning KW - Life history KW - Vegetation changes KW - Chaparral KW - Conservation KW - USA, California KW - Species richness KW - abundance KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies KW - ENA 05:Environmental Design & Urban Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860392702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urban+Ecosystems&rft.atitle=Patterns+of+human+disturbance+and+response+by+small+mammals+and+birds+in+chaparral+near+urban+development&rft.au=Sauvajot%2C+Raymond+M%3BBuechner%2C+Marybeth%3BKamradt%2C+Denise+A%3BSchonewald%2C+Christine+M&rft.aulast=Sauvajot&rft.aufirst=Raymond&rft.date=1998-12-01&rft.volume=2&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Urban+Ecosystems&rft.issn=10838155&rft_id=info:doi/10.1023%2FA%3A1009588723665 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Fires; Urbanization; Abundance; Vegetation; Development; Habitat; Trampling; Solid wastes; Life history; Vegetation changes; Chaparral; Conservation; Species richness; Urban planning; Aves; mammals; disturbance; life history; chaparral; abundance; USA, California DO - http://dx.doi.org/10.1023/A:1009588723665 ER - TY - JOUR T1 - Oxidized resin acids in aerosol derived from rosin core solder. AN - 69095622; 9866169 AB - Exposure to rosin during a variety of uses has been associated with dermal and pulmonary sensitization. Oxidized resin acids are present in many rosin products, and have been regarded as the main sensitizing rosin compounds in cases of dermal sensitization. This research describes oxidized resin acids identified in aerosol produced during soldering with rosin core solder. Oxidized resin acids found were 7-oxodehydroabietic acid, 15-hydroxydehydroabietic acid, and 7-hydroxydehydroabietic acid. The presence of oxidized compounds known to be dermal sensitizers in aerosol from rosin flux soldering supports the hypothesis that resin acid compounds are pulmonary sensitizers as previously proposed. Changes in the composition of resin acid aerosol derived from heated rosin core solder (compared with the parent material) are described. JF - American Industrial Hygiene Association journal AU - Smith, P A AU - Gardner, D R AU - Drown, D B AU - Jederberg, W W AU - Still, K AD - Uniformed Services, University of the Health Sciences, Department of Preventive Medicine and Biometrics, Bethesda, MD, USA. Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 889 EP - 894 VL - 59 IS - 12 SN - 0002-8894, 0002-8894 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Diterpenes KW - Diterpenes, Abietane KW - Phenanthrenes KW - Resins, Plant KW - rosin KW - 88S87KL877 KW - abietic acid KW - V3DHX33184 KW - Index Medicus KW - Oxidation-Reduction KW - Mass Spectrometry KW - Chromatography, Gas KW - Humans KW - Asthma -- chemically induced KW - Phenanthrenes -- analysis KW - Diterpenes -- analysis KW - Resins, Plant -- adverse effects KW - Air Pollutants, Occupational -- analysis KW - Air Pollutants, Occupational -- adverse effects KW - Diterpenes -- adverse effects KW - Phenanthrenes -- adverse effects KW - Resins, Plant -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69095622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Oxidized+resin+acids+in+aerosol+derived+from+rosin+core+solder.&rft.au=Smith%2C+P+A%3BGardner%2C+D+R%3BDrown%2C+D+B%3BJederberg%2C+W+W%3BStill%2C+K&rft.aulast=Smith&rft.aufirst=P&rft.date=1998-12-01&rft.volume=59&rft.issue=12&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-09 N1 - Date created - 1999-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells. AN - 70044852; 9804779 AB - Transcription factors of the Stat family are controlled by protein kinases. Phosphorylation of a positionally conserved tyrosine residue is obligatory for Stat dimerization, nuclear translocation, and specific DNA binding. Studies of Stat1 and Stat3 have suggested that serine phosphorylation may also regulate function. We now identify serine residues located in a conserved PSP motif of Stat5a (Ser725) and Stat5b (Ser730) as major phosphorylation sites, using mutagenesis, phosphoamino acid analysis, and site-specific anti-Stat5-phosphoserine antibodies. Unexpectedly, phosphorylation control of this PSP motif differed between the highly homologous Stat5a and Stat5b proteins. Whereas Ser725 of Stat5a was constitutively phosphorylated both in COS-7 cells and Nb2 lymphocytes, phosphorylation of Ser730 of Stat5b was markedly stimulated by prolactin. The data also suggested the existence of a second major serine phosphorylation site in Stat5a. Interestingly, constitutive phosphorylation of the PSP motif was suppressed by PD98059 but not by staurosporine under conditions in which both agents inhibited mitogen-activated protein kinases. Furthermore, pretreatment of cells with staurosporine, PD98059, H7, or wortmannin did not prevent either Stat5a or Stat5b from becoming maximally serine-phosphorylated after prolactin exposure. We propose that two pathways regulate Stat5 serine phosphorylation, one that is prolactin-activated and PD98059-resistant and one that is constitutively active and PD98059-sensitive and preferentially targets Stat5a. Finally, phosphorylation of the PSP motif of Stat5a or Stat5b was not essential for DNA binding or transcriptional activation of a beta-casein reporter gene in COS-7 cells, suggesting that serine kinase control of Stat5 activity differs from that of Stat1 and Stat3. JF - The Journal of biological chemistry AU - Yamashita, H AU - Xu, J AU - Erwin, R A AU - Farrar, W L AU - Kirken, R A AU - Rui, H AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1998/11/13/ PY - 1998 DA - 1998 Nov 13 SP - 30218 EP - 30224 VL - 273 IS - 46 SN - 0021-9258, 0021-9258 KW - Caseins KW - 0 KW - DNA-Binding Proteins KW - Milk Proteins KW - Phosphoamino Acids KW - STAT5 Transcription Factor KW - Trans-Activators KW - Serine KW - 452VLY9402 KW - Prolactin KW - 9002-62-4 KW - DNA KW - 9007-49-2 KW - Proline KW - 9DLQ4CIU6V KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Animals KW - COS Cells KW - DNA -- metabolism KW - Transcriptional Activation -- drug effects KW - Amino Acid Sequence KW - Structure-Activity Relationship KW - Caseins -- metabolism KW - Caseins -- genetics KW - Phosphorylation KW - Alanine -- metabolism KW - Genes, Reporter KW - Molecular Sequence Data KW - Amino Acid Substitution KW - Phosphoamino Acids -- metabolism KW - Trans-Activators -- metabolism KW - Proline -- metabolism KW - Prolactin -- pharmacology KW - Serine -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70044852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Differential+control+of+the+phosphorylation+state+of+proline-juxtaposed+serine+residues+Ser725+of+Stat5a+and+Ser730+of+Stat5b+in+prolactin-sensitive+cells.&rft.au=Yamashita%2C+H%3BXu%2C+J%3BErwin%2C+R+A%3BFarrar%2C+W+L%3BKirken%2C+R+A%3BRui%2C+H&rft.aulast=Yamashita&rft.aufirst=H&rft.date=1998-11-13&rft.volume=273&rft.issue=46&rft.spage=30218&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-12-08 N1 - Date created - 1998-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Groundwater plume containment through cometabolic biodegradation of trichloroethylene AN - 51741143; 2005-024192 JF - Eos, Transactions, American Geophysical Union AU - McCarty, P L AU - Goltz, M N AU - Hopkins, G D AU - Kawakami, B T AU - Anonymous Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 362 PB - American Geophysical Union, Washington, DC VL - 79 IS - 45, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - halides KW - chlorinated hydrocarbons KW - biodegradation KW - plumes KW - pollutants KW - pollution KW - bromides KW - ground water KW - aquifers KW - California KW - Kern County California KW - organic compounds KW - Southern California KW - Edwards Air Force Base KW - halogenated hydrocarbons KW - trichloroethylene KW - military facilities KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51741143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Groundwater+plume+containment+through+cometabolic+biodegradation+of+trichloroethylene&rft.au=McCarty%2C+P+L%3BGoltz%2C+M+N%3BHopkins%2C+G+D%3BKawakami%2C+B+T%3BAnonymous&rft.aulast=McCarty&rft.aufirst=P&rft.date=1998-11-01&rft.volume=79&rft.issue=45%2C+Suppl.&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1998 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - aquifers; biodegradation; bromides; California; chlorinated hydrocarbons; Edwards Air Force Base; ground water; halides; halogenated hydrocarbons; Kern County California; military facilities; organic compounds; plumes; pollutants; pollution; Southern California; trichloroethylene; United States ER - TY - JOUR T1 - Visualization of megaripples in the foreshore by variance imaging AN - 51735846; 2005-022807 JF - Eos, Transactions, American Geophysical Union AU - Chickadel, C C AU - Holman, Robert A AU - Gallagher, E L AU - Anonymous Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 445 PB - American Geophysical Union, Washington, DC VL - 79 IS - 45, Suppl. SN - 0096-3941, 0096-3941 KW - imagery KW - Global Positioning System KW - experimental studies KW - monitoring KW - erosion KW - SandyDuck KW - sedimentation KW - pixels KW - nearshore environment KW - ripple marks KW - climate change KW - variations KW - visualization KW - bedding plane irregularities KW - coastal environment KW - sedimentary structures KW - climate KW - 06A:Sedimentary petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51735846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Visualization+of+megaripples+in+the+foreshore+by+variance+imaging&rft.au=Chickadel%2C+C+C%3BHolman%2C+Robert+A%3BGallagher%2C+E+L%3BAnonymous&rft.aulast=Chickadel&rft.aufirst=C&rft.date=1998-11-01&rft.volume=79&rft.issue=45%2C+Suppl.&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1998 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - bedding plane irregularities; climate; climate change; coastal environment; erosion; experimental studies; Global Positioning System; imagery; monitoring; nearshore environment; pixels; ripple marks; SandyDuck; sedimentary structures; sedimentation; variations; visualization ER - TY - JOUR T1 - Vertical and horizontal length scales of suspended sediment in the nearshore AN - 51707075; 2005-045198 JF - Eos, Transactions, American Geophysical Union AU - Thornton, Edward B AU - Huck, Michael P AU - Stanton, Timothy P AU - Anonymous Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 416 PB - American Geophysical Union, Washington, DC VL - 79 IS - 45, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - methods KW - optical properties KW - North Carolina KW - sedimentation KW - nearshore sedimentation KW - Duck North Carolina KW - Dare County North Carolina KW - techniques KW - suspended materials KW - acoustical waves KW - 06A:Sedimentary petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51707075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Vertical+and+horizontal+length+scales+of+suspended+sediment+in+the+nearshore&rft.au=Thornton%2C+Edward+B%3BHuck%2C+Michael+P%3BStanton%2C+Timothy+P%3BAnonymous&rft.aulast=Thornton&rft.aufirst=Edward&rft.date=1998-11-01&rft.volume=79&rft.issue=45%2C+Suppl.&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1998 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - acoustical waves; Dare County North Carolina; Duck North Carolina; methods; nearshore sedimentation; North Carolina; optical properties; sedimentation; suspended materials; techniques; United States ER - TY - JOUR T1 - Nicotine Administration Impairs Sensory Gating in Long-Evans Rats AN - 17407126; 4632591 AB - In rats, effects of nicotine administration on sensory gating as indexed by prepulse inhibition (PPI) of the acoustic startle reflex (ASR) are unclear. We have found that nicotine administration enhances ASR and PPI in Sprague-Dawley rats, but other investigators, using Long-Evans rats, have reported no effects or enhancement of PPI only. Numerous methodological differences exist among studies in addition to subject strain, however, making it unclear whether inconsistent behavioral responses are the result of different experimental procedures or indicate a true strain difference. To investigate the role of strain in nicotine's effects on ASR and PPI, 192 male and female Long-Evans rats were administered 12 mg/kg/day nicotine via osmotic minipump for 14 days using identical methodologies employed in studies with Sprague-Dawley subjects. Effects of grouped vs. individual housing on these responses also were examined. Nicotine administration impaired ASR and PPI in Long-Evans subjects. These effects occurred in female rats regardless of housing condition, and interacted with housing in male rats. Results indicate that sex and housing are important variables in nicotine's effects. Results suggest that subject strain may be an important variable in nicotine's effects on sensory gating, and that responses of Sprague-Dawley vs. Long-Evans rats may represent a true strain difference. JF - Pharmacology Biochemistry and Behavior AU - Faraday, M M AU - Rahman, MA AU - Scheufele, P M AU - Grunberg, N E AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences (USUHS), 4301 Jones Bridge Road, Bethesda, MD 20814, USA Y1 - 1998/11// PY - 1998 DA - Nov 1998 SP - 281 EP - 289 VL - 61 IS - 3 SN - 0091-3057, 0091-3057 KW - rats KW - prepulse inhibition KW - Toxicology Abstracts; Animal Behavior Abstracts KW - Sensory stimuli KW - Sense functions KW - Acoustic startle response KW - Nicotine KW - Gating KW - Sex differences KW - Y 25777:Mammals (excluding primates) KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17407126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Nicotine+Administration+Impairs+Sensory+Gating+in+Long-Evans+Rats&rft.au=Faraday%2C+M+M%3BRahman%2C+MA%3BScheufele%2C+P+M%3BGrunberg%2C+N+E&rft.aulast=Faraday&rft.aufirst=M&rft.date=1998-11-01&rft.volume=61&rft.issue=3&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/10.1016%2FS0091-3057%2898%2900094-X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Gating; Sensory stimuli; Nicotine; Sex differences; Sense functions; Acoustic startle response DO - http://dx.doi.org/10.1016/S0091-3057(98)00094-X ER - TY - JOUR T1 - Urinary and serum mutagenicity studies with rats implanted with depleted uranium or tantalum pellets AN - 17343298; 4624254 AB - During the 1991 Persian Gulf War several US military personnel were wounded by shrapnel fragments consisting of depleted uranium. These fragments were treated as conventional shrapnel and were not surgically removed to spare excessive tissue damage. Uranium bioassays conducted over a year after the initial uranium injury indicated a significant increase in urine uranium levels above natural background levels. The potential mutagenic effects of depleted uranium are unknown. To assess the potential mutagenic effects of long-term exposure to internalized depleted uranium, Sprague-Dawley rats were implanted with depleted uranium and their urine and serum were evaluated for mutagenic potential at various times after pellet implantation using the Ames Salmonella reversion assay. Tantalum, an inert metal widely used in prosthetic devices was used for comparison. Enhancement of mutagenic activity in Salmonella typhimurium strain TA98 and the Ames II mixed strains (TA7001-7006) was observed in urine samples from animals implanted with depleted uranium pellets. In contrast, urine samples from animals implanted with tantalum did not show a significant enhancement of mutagenic activity in these strains. In depleted uranium-implanted animals, urine mutagenicity increased in a dose- and time-dependent manner demonstrating a strong positive correlation with urine uranium levels (r = 0.995, P < 0.001). There was no mutagenic enhancement of any bacterial strain detected in the sera of animals implanted with either depleted uranium or tantalum pellets. The results suggest that uranium content in the urine is correlated with urine mutagenicity and that urinary mutagenicity might be used as a biomarker to detect exposure to internalized uranium. JF - Mutagenesis AU - Miller, A C AU - Fuciarelli, A F AU - Jackson, W E AU - Ejnik, E J AU - Emond, C AU - Strocko, S AU - Hogan, J AU - Page, N AU - Pellmar, T AD - Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5603, USA, millera@mx.afrri.usuhs.mil Y1 - 1998/11// PY - 1998 DA - Nov 1998 SP - 643 EP - 648 VL - 13 IS - 6 SN - 0267-8357, 0267-8357 KW - rats KW - serum KW - tantalum KW - urine KW - Genetics Abstracts; Toxicology Abstracts KW - Mutagenicity KW - Uranium KW - X 24165:Biochemistry KW - G 07221:Specific chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17343298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Urinary+and+serum+mutagenicity+studies+with+rats+implanted+with+depleted+uranium+or+tantalum+pellets&rft.au=Miller%2C+A+C%3BFuciarelli%2C+A+F%3BJackson%2C+W+E%3BEjnik%2C+E+J%3BEmond%2C+C%3BStrocko%2C+S%3BHogan%2C+J%3BPage%2C+N%3BPellmar%2C+T&rft.aulast=Miller&rft.aufirst=A&rft.date=1998-11-01&rft.volume=13&rft.issue=6&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=02678357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mutagenicity; Uranium ER - TY - JOUR T1 - Ionizing radiation potentiates the induction of nitric oxide synthase by IFN-gamma and/or LPS in murine macrophage cell lines: role of TNF-alpha. AN - 69952863; 9766626 AB - Macrophages are activated to become cytotoxic by a highly coordinated set of cytokine signals. Ionizing radiation can mimic cytokine signals and lead to enhanced states of activation. We tested the ability of gamma-radiation, alone and with interferon-gamma (IFN-gamma) and/or lipopolysaccharide (LPS), to induce nitric oxide (NO) production in J774.1 and RAW264.7 murine macrophages. NO was induced weakly, moderately, or strongly by IFN-gamma alone, LPS alone, or IFN-gamma + LPS, respectively. Radiation alone (0.5-50 Gy) did not induce NO, but enhanced NO production in a dose-dependent manner (0.5-5 Gy) when cells were exposed to IFN-gamma or LPS 24 h post-irradiation. Immunoblots showed parallel induction of nitric oxide synthase (NOS2). Application of anti-tumor necrosis factor alpha (TNF-alpha) antibody before irradiation blocked induction of NO by IFN-gamma. We conclude (1) that irradiated cells produce more NO in response to either IFN-gamma or LPS and (2) that the increase is mediated by induction of TNF-alpha. JF - Journal of leukocyte biology AU - McKinney, L C AU - Aquilla, E M AU - Coffin, D AU - Wink, D A AU - Vodovotz, Y AD - Department of Radiation Pathophysiology and Toxicology, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA. mckinney@mx.afrri.usuhs.mil Y1 - 1998/10// PY - 1998 DA - October 1998 SP - 459 EP - 466 VL - 64 IS - 4 SN - 0741-5400, 0741-5400 KW - Antibodies KW - 0 KW - Cobalt Radioisotopes KW - Lipopolysaccharides KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Nitric Oxide KW - 31C4KY9ESH KW - Interferon-gamma KW - 82115-62-6 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Index Medicus KW - Animals KW - Artifacts KW - Gamma Rays KW - Mice KW - Nitric Oxide -- biosynthesis KW - Dose-Response Relationship, Radiation KW - Enzyme Induction -- radiation effects KW - Enzyme Induction -- drug effects KW - Kinetics KW - Escherichia coli KW - Cell Line KW - Macrophages -- enzymology KW - Lipopolysaccharides -- pharmacology KW - Tumor Necrosis Factor-alpha -- immunology KW - Interferon-gamma -- pharmacology KW - Tumor Necrosis Factor-alpha -- physiology KW - Macrophages -- drug effects KW - Macrophages -- radiation effects KW - Nitric Oxide Synthase -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69952863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Ionizing+radiation+potentiates+the+induction+of+nitric+oxide+synthase+by+IFN-gamma+and%2For+LPS+in+murine+macrophage+cell+lines%3A+role+of+TNF-alpha.&rft.au=McKinney%2C+L+C%3BAquilla%2C+E+M%3BCoffin%2C+D%3BWink%2C+D+A%3BVodovotz%2C+Y&rft.aulast=McKinney&rft.aufirst=L&rft.date=1998-10-01&rft.volume=64&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-10-26 N1 - Date created - 1998-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pyruvate prevents hydrogen peroxide-induced apoptosis. AN - 69096311; 9860043 AB - Studies were carried out to investigate the protective effects of pyruvate, a key glycolytic intermediate and alpha-keto-monocarboxylate, against oxidative stress-induced apoptosis. Oxidative stress was induced by treating mouse thymocytes with 25 microM hydrogen peroxide for 15 min at 37 degrees C under 5% CO2 in air. Pre- and post-treatment of cells with 10 mM pyruvate inhibited morphological changes, internucleosomal DNA fragmentation, and translocation of phosphatidylserine to the plasma membrane surface, which are characteristic features of apoptosis. L-lactate (10 mM) and acetate (10 mM) were ineffective in inhibiting apoptosis and appeared to be toxic to the cells under similar conditions. The results suggest that pyruvate has therapeutic potential for use in the treatment of oxidative stress-induced disorders associated with increased apoptosis. JF - Free radical research AU - Ramakrishnan, N AU - Chen, R AU - McClain, D E AU - Bünger, R AD - Department of Applied Cellular Radiobiology, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889-5603, USA. Rama@mx.afrri.usuhs.mil Y1 - 1998/10// PY - 1998 DA - October 1998 SP - 283 EP - 295 VL - 29 IS - 4 SN - 1071-5762, 1071-5762 KW - Acetates KW - 0 KW - Annexin A5 KW - Phosphatidylserines KW - Lactic Acid KW - 33X04XA5AT KW - Propidium KW - 36015-30-2 KW - Pyruvic Acid KW - 8558G7RUTR KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Animals KW - T-Lymphocytes -- cytology KW - Cell Membrane -- drug effects KW - Phosphatidylserines -- metabolism KW - Mice KW - Annexin A5 -- metabolism KW - Acetates -- pharmacology KW - Cell Size -- drug effects KW - Mice, Inbred Strains KW - T-Lymphocytes -- metabolism KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Thymus Gland KW - Oxidative Stress -- drug effects KW - DNA Fragmentation -- drug effects KW - Flow Cytometry KW - T-Lymphocytes -- drug effects KW - Cell Membrane -- metabolism KW - Lactic Acid -- pharmacology KW - Male KW - Pyruvic Acid -- pharmacology KW - Hydrogen Peroxide -- pharmacology KW - Apoptosis -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69096311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+research&rft.atitle=Pyruvate+prevents+hydrogen+peroxide-induced+apoptosis.&rft.au=Ramakrishnan%2C+N%3BChen%2C+R%3BMcClain%2C+D+E%3BB%C3%BCnger%2C+R&rft.aulast=Ramakrishnan&rft.aufirst=N&rft.date=1998-10-01&rft.volume=29&rft.issue=4&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Free+radical+research&rft.issn=10715762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-23 N1 - Date created - 1999-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reproductive ecology and early life history of a lacustrine sculpin, Cottus extensus (Teleostei, Cottidae) AN - 17192835; 4483839 AB - Using a variety of sampling techniques and observations we describe aspects of the reproductive ecology and early life-history of Bear Lake sculpin, Cottus extensus, a species endemic to Bear Lake, Utah-Idaho. Adult sculpin spawned in shallow water (0.5-6.0 m depths) in cavities beneath large cobbles and boulders. During 1993, egg mass densities were highest (> 4.0 m super(2)) at 1.0-2.0 m depths. Electivity indices verified substrate selection and also indicated an avoidance of sand- and gravel-embedded materials. During years of low water elevation, suitable spawning substrates were restricted to one or two limited areas of the lake and comprised < 0.004% of the total benthic area. Disturbance from turbulence, as would be produced by storm-induced waves, appeared to initiate hatching. After hatching, embryos passed through a pelagic interval that lasted for approximately one week. Laboratory experiments confirmed the short duration of this surface-swimming behavior. The pelagic behavior of free embryos appears to aid in dispersal of fish Via currents from limited spawning habitats to areas throughout the 282 km super(2) lake. JF - Environmental Biology of Fishes AU - Ruzycki, J R AU - Wurtsbaugh, WA AU - Lay, C AD - National Park Service, Aquatic Resources Center, P.O. Box 168, Yellowstone National Park, WY 82190, USA, jim_ruzycki@nps.gov Y1 - 1998/10// PY - 1998 DA - Oct 1998 SP - 117 EP - 127 VL - 53 IS - 2 SN - 0378-1909, 0378-1909 KW - Bear lake sculpin KW - Animal Behavior Abstracts; Ecology Abstracts KW - Life history KW - Cottus extensus KW - Reproductive behavior KW - D 04668:Fish KW - Y 25425:Fish UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17192835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Biology+of+Fishes&rft.atitle=Reproductive+ecology+and+early+life+history+of+a+lacustrine+sculpin%2C+Cottus+extensus+%28Teleostei%2C+Cottidae%29&rft.au=Ruzycki%2C+J+R%3BWurtsbaugh%2C+WA%3BLay%2C+C&rft.aulast=Ruzycki&rft.aufirst=J&rft.date=1998-10-01&rft.volume=53&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Environmental+Biology+of+Fishes&rft.issn=03781909&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cottus extensus; Life history; Reproductive behavior ER - TY - JOUR T1 - Redox-Dependent Acetyl Transfer Partial Reaction of the Acetyl-CoA Decarbonylase/Synthase Complex: Kinetics and Mechanism AN - 17145042; 4437514 AB - Acetyl-CoA decarbonylase/synthase (ACDS) is a multienzyme complex that plays a central role in energy metabolism in Methanosarcina barkeri grown on acetate. The ACDS complex carries out an unusual reaction involving net cleavage of the acetyl C-C and thioester bonds of acetyl-CoA. The overall reaction is composed of several partial reactions, one of which involves catalysis of acetyl group transfer. To gain insight into the overall reaction, a study was carried out on the kinetics and mechanism of the acetyltransferase partial reaction. Analysis by HPLC was used to quantify rates of acetyl transfer from acetyl-CoA both to 3'-dephospho-CoA and, by isotope exchange, to super(14)C-labeled CoA. Acetyl transfer activity was observed only under strongly reducing conditions, and was half-maximal at -486 mV at pH 6.5. The midpoint activation potential became increasingly more negative as the pH was increased, indicating the involvement of a protonation step. Cooperative dependence on acetyl-CoA concentration was exhibited in reactions that contained incompletely reduced enzyme; however, under redox conditions supporting maximum activity, hyperbolic kinetics were found. A ping-pong steady state kinetic mechanism was established, consistent with formation of an acetyl-enzyme intermediate. Analysis of the inhibitory effects of CoA on acetyl transfer to 3'-dephospho-CoA provided values for K sub(i) super(CoA) of 6.8 mu M and for K sub(i) super(acetyl-CoA) of 45 mu M; isotope exchange analyses yielded values of 32 and 120 mu M, respectively. Two separate measures of stability yielded values for the free energy of hydrolysis of the acetyl-enzyme intermediate of -9.6 and -9.3 kcal/mol, an indication of a high-energy bonding interaction in the acetyl-enzyme species. Implications for the mechanism of C-C bond cleavage are discussed. JF - Biochemistry (Washington) AU - Bhaskar, B AU - DeMoll, E AU - Grahame, DA AD - Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA Y1 - 1998/10// PY - 1998 DA - Oct 1998 SP - 14491 EP - 14499 VL - 37 IS - 41 SN - 0006-2960, 0006-2960 KW - acetyl-CoA decarbonylase/synthase KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - High-performance liquid chromatography KW - Energy KW - Kinetics KW - Methanosarcina barkeri KW - pH effects KW - A 01006:Enzymes & cofactors KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17145042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Redox-Dependent+Acetyl+Transfer+Partial+Reaction+of+the+Acetyl-CoA+Decarbonylase%2FSynthase+Complex%3A+Kinetics+and+Mechanism&rft.au=Bhaskar%2C+B%3BDeMoll%2C+E%3BGrahame%2C+DA&rft.aulast=Bhaskar&rft.aufirst=B&rft.date=1998-10-01&rft.volume=37&rft.issue=41&rft.spage=14491&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Methanosarcina barkeri; Kinetics; pH effects; Energy; High-performance liquid chromatography ER - TY - JOUR T1 - Shigella infection as observed in the experimentally inoculated domestic pig, sus scrofa domestica AN - 17141792; 4442824 AB - The domestic pig, Sus scrofa domestica, was investigated as a potential animal model for shigellosis. We examined the effects of pig age, pig breed and antibiotic pretreatment upon Shigella infection. Shigella dysenteriae, and Shigella flexneri (both virulent and avirulent strains) were utilized. Our results indicated that young (4-week-old), conventionally reared, domestic pigs were routinely, but briefly, colonized (average = 3.5 plus or minus 2.5 days) following oral or gavage administration of S. flexneri, as determined by direct rectal cultures. The duration of S. dysenteriae colonization was significantly shorter. Inoculation of younger (2 days) or older (9 weeks) pigs with S. flexneri had no significant effect on infection duration. Similarly, infection of 4-week-old pigs with virulent and avirulent strains of S. flexneri had no effect upon the duration of infection, nor did the use of a swine-passaged S. flexneri isolate. Marked clinical, histopathological (gross and microscopic) and immuno-histopathological signs of disease were absent in all infections. However, in instances where microscopic histopathological evidence was used to correctly identify infected pigs, tonsillar lesions were the consistently noted criteria. The tonsils are believed to be an important portal of entry for Salmonella choleraesuis, another member of the Enterobacteriaceae and a prevalent pig pathogen. Taken altogether, our results indicate that the domestic pig is unsuitable as a model for shigellosis. JF - Microbial Pathogenesis AU - Maurelli, A T AU - Routh, PR AU - Dillman, R C AU - Ficken, MD AU - Weinstock, D M AU - Almond, G W AU - Orndorff, P E AD - Department of Microbiology and Immunology, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA Y1 - 1998/10// PY - 1998 DA - Oct 1998 SP - 189 EP - 196 VL - 25 IS - 4 SN - 0882-4010, 0882-4010 KW - Microbiology Abstracts B: Bacteriology KW - Salmonella choleraesuis KW - Sus scrofa domestica KW - Tonsil KW - Shigellosis KW - Shigella flexneri KW - Animal models KW - Livestock KW - Shigella dysenteriae KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17141792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Shigella+infection+as+observed+in+the+experimentally+inoculated+domestic+pig%2C+sus+scrofa+domestica&rft.au=Maurelli%2C+A+T%3BRouth%2C+PR%3BDillman%2C+R+C%3BFicken%2C+MD%3BWeinstock%2C+D+M%3BAlmond%2C+G+W%3BOrndorff%2C+P+E&rft.aulast=Maurelli&rft.aufirst=A&rft.date=1998-10-01&rft.volume=25&rft.issue=4&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Salmonella choleraesuis; Shigella dysenteriae; Shigella flexneri; Sus scrofa domestica; Shigellosis; Tonsil; Livestock; Animal models ER - TY - JOUR T1 - Engineering a recombinant Deinococcus radiodurans for organopollutant degradation in radioactive mixed waste environments AN - 16507683; 4415753 AB - Thousands of waste sites around the world contain mixtures of toxic chlorinated solvents, hydrocarbon solvents, and radionuclides. Because of the inherent danger and expense of cleaning up such wastes by physicochemical methods, other methods are being pursued for cleanup of those sites. One alternative is to engineer radiation-resistant microbes that degrade or transform such wastes to less hazardous mixtures. We describe the construction and characterization of recombinant Deinococcus radiodurans, the most radiation-resistant organism known, expressing toluene dioxygenase (TDO). Cloning of the tod genes (which encode the multicomponent TDO) into the chromosome of this bacterium imparted to the strain the ability to oxidize toluene, chlorobenzene, 3,4-dichloro-1-butene, and indole. The recombinant strain was capable of growth and functional synthesis of TDO in the highly irradiating environment (60 Gy/h) of a super(137)Cs irradiator, where 5 x 10 super(8) cells/ml degraded 125 nmol/ml of chlorobenzene in 150 min. D. radiodurans strains were also tolerant to the solvent effects of toluene and trichloroethylene at levels exceeding those of many radioactive waste sites. These data support the prospective use of engineered D. radiodurans for bioremediation of mixed wastes containing both radionuclides and organic solvents. JF - Nature Biotechnology AU - Lange, C C AU - Wackett, L P AU - Minton, K W AU - Daly, MJ AD - Department of Pathology, Uniformed Services, University of the Health Sciences, Bethesda, MD 20814, USA, mdaly@usuhs.mil Y1 - 1998/10// PY - 1998 DA - Oct 1998 SP - 929 EP - 933 VL - 16 IS - 10 SN - 1087-0156, 1087-0156 KW - Deinococcus radiodurans KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Agricultural and Environmental Biotechnology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION KW - J 02901:Soil and plants KW - W2 32580:Fermentation and process engineering KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16507683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Engineering+a+recombinant+Deinococcus+radiodurans+for+organopollutant+degradation+in+radioactive+mixed+waste+environments&rft.au=Lange%2C+C+C%3BWackett%2C+L+P%3BMinton%2C+K+W%3BDaly%2C+MJ&rft.aulast=Lange&rft.aufirst=C&rft.date=1998-10-01&rft.volume=16&rft.issue=10&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages. AN - 73890460; 9725248 AB - Ceramide is a well-known apoptotic agent that has been implicated in LPS signaling. Therefore, we examined whether LPS-induced macrophage cytotoxicity is mediated by mimicking ceramide. Both LPS and the cell-permeable ceramide analogue, C2 ceramide, induced significant cell death in IFN-gamma-activated, thioglycollate-elicited peritoneal macrophages after 48 and 24 h, respectively. Ceramide-induced cell death was neither accompanied by DNA fragmentation nor phosphatidyl serine externalization, characteristics of apoptosis. In contrast, LPS induced a significant fraction of cells to undergo apoptosis, as demonstrated by DNA fragmentation and quantified by DNA analysis on FACS, yet the majority of the cells died in a necrotic fashion. C3H/HeJ Lps(d) macrophages were resistant to LPS-induced cell death and less sensitive to C2 ceramide-evoked cytotoxicity, when compared with Lps(n) macrophages. C2 ceramide plus IFN-gamma failed to activate release of nitric oxide (NO.), whereas LPS-induced cell death, but not C2-induced cytotoxicity, was blocked by an inhibitor of inducible NO. synthase (iNOS), NG-monomethyl-L-arginine. Macrophages from IFN regulatory factor-1 (-/-) mice shown previously to respond marginally to LPS plus IFN-gamma to express iNOS mRNA and NO., were refractory to LPS plus IFN-gamma-induced cytotoxicity and apoptosis. These data suggest that although LPS may mimic certain ceramide effects, signal transduction events that lead to cytotoxicity, as well as the downstream mediators, diverge. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Lakics, V AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 1998/09/01/ PY - 1998 DA - 1998 Sep 01 SP - 2490 EP - 2500 VL - 161 IS - 5 SN - 0022-1767, 0022-1767 KW - DNA-Binding Proteins KW - 0 KW - Interferon Regulatory Factor-1 KW - Irf1 protein, mouse KW - Lipopolysaccharides KW - N-acetylsphingosine KW - Phosphoproteins KW - Tumor Necrosis Factor-alpha KW - Interferon-gamma KW - 82115-62-6 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type II KW - Nos2 protein, mouse KW - Sphingosine KW - NGZ37HRE42 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Phosphoproteins -- physiology KW - Apoptosis -- immunology KW - Interferon-gamma -- pharmacology KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Mice KW - Cell Death -- drug effects KW - Mice, Knockout KW - Necrosis KW - Apoptosis -- drug effects KW - Mice, Inbred C3H KW - DNA-Binding Proteins -- physiology KW - Cytotoxicity, Immunologic -- drug effects KW - Nitric Oxide Synthase -- metabolism KW - Drug Synergism KW - Female KW - Lipopolysaccharides -- pharmacology KW - Signal Transduction -- drug effects KW - Signal Transduction -- immunology KW - Sphingosine -- pharmacology KW - Macrophages, Peritoneal -- immunology KW - Sphingosine -- analogs & derivatives KW - Macrophages, Peritoneal -- pathology KW - Macrophages, Peritoneal -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73890460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Lipopolysaccharide+and+ceramide+use+divergent+signaling+pathways+to+induce+cell+death+in+murine+macrophages.&rft.au=Lakics%2C+V%3BVogel%2C+S+N&rft.aulast=Lakics&rft.aufirst=V&rft.date=1998-09-01&rft.volume=161&rft.issue=5&rft.spage=2490&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-10 N1 - Date created - 1998-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Glucocorticoid-induced apoptosis and regulation of NF-kappaB activity in human leukemic T cells. AN - 73869894; 9724034 AB - Glucocorticoid-induced apoptosis was investigated in glucocorticoid-sensitive 6TG1.1 and resistant ICR27TK.3 human leukemic T cells. Following glucocorticoid treatment of 6TG1.1 cells, chromatin fragmentation was observed after a delay of 24 h. Fragmentation was not observed in ICR27TK.3 cells containing mutant glucocorticoid receptors (L753F) that are activation-deficient but retain the ability to repress AP-1 activity. Nor was fragmentation observed after treatment with RU38486, indicating that repression of AP-1 activity is not involved. As described in other systems, fragmentation required ongoing protein synthesis. However, inhibition of protein synthesis with cycloheximide anytime during the first 18 h of steroid treatment was as effective in blocking chromatin fragmentation as inhibition for the entire period, suggesting that synthesis of a component with a rapid turnover rate is required. Dexamethasone treatment completely blocked 12-O-tetradecanoylphorbol 13-acetate induction of nuclear factor-kappaB (NF-kappaB) activity and elicited an increase in the amount of immunoreactive IkappaB alpha in sensitive 6TG1.1 cells but not in resistant ICR27TK.3 cells. In addition, mild detergent treatment of cell extracts indicated that a substantial amount of cytoplasmic NF-kappaB is complexed with IkappaB alpha or some other inhibitory factor. These results suggest that induction of a labile inhibitory factor such as IkappaB alpha may contribute to glucocorticoid-induced apoptosis. JF - Endocrinology AU - Ramdas, J AU - Harmon, J M AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1998/09// PY - 1998 DA - September 1998 SP - 3813 EP - 3821 VL - 139 IS - 9 SN - 0013-7227, 0013-7227 KW - Chromatin KW - 0 KW - Glucocorticoids KW - NF-kappa B KW - Receptors, Glucocorticoid KW - Mifepristone KW - 320T6RNW1F KW - Dexamethasone KW - 7S5I7G3JQL KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Tumor Cells, Cultured KW - Mutation -- physiology KW - Humans KW - Dexamethasone -- pharmacology KW - Chromatin -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Drug Resistance KW - DNA Fragmentation -- drug effects KW - DNA Fragmentation -- physiology KW - Tetradecanoylphorbol Acetate -- antagonists & inhibitors KW - Receptors, Glucocorticoid -- genetics KW - Mifepristone -- pharmacology KW - Chromatin -- genetics KW - Leukemia -- pathology KW - T-Lymphocytes -- metabolism KW - Leukemia -- metabolism KW - Apoptosis -- physiology KW - T-Lymphocytes -- physiology KW - T-Lymphocytes -- drug effects KW - Leukemia -- physiopathology KW - Glucocorticoids -- pharmacology KW - NF-kappa B -- metabolism KW - NF-kappa B -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73869894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Glucocorticoid-induced+apoptosis+and+regulation+of+NF-kappaB+activity+in+human+leukemic+T+cells.&rft.au=Ramdas%2C+J%3BHarmon%2C+J+M&rft.aulast=Ramdas&rft.aufirst=J&rft.date=1998-09-01&rft.volume=139&rft.issue=9&rft.spage=3813&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-23 N1 - Date created - 1998-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300. AN - 73865246; 9710589 AB - Human T-cell lymphotropic virus type 1 (HTLV-1) transcriptional activation is mediated by the viral transactivator, Tax, and three 21-bp repeats (Tax response element [TxRE]) located in the U3 region of the viral long terminal repeat (LTR). Each TxRE contains a core cyclic AMP response element (CRE) flanked by 5' G-rich and 3' C-rich sequences. The TxRE binds CREB (CRE-binding protein) and Tax to form a ternary complex and confers Tax-dependent transactivation. Recent data indicate that Tax functions as a specific link to connect CREB-binding protein (CBP)/p300 in a phosphorylation-independent manner to CREB/ATF-1 assembled on the viral 21-bp repeats. Glutathione S-transferase pull-down performed with Tax deletion mutants and peptide competition have localized the site in Tax critical for binding CBP/p300 to a highly protease-sensitive region around amino acid residues 81 to 95 (81QRTSKTLKVLTPPIT95) which lies between the domains previously proposed to be important for CREB binding and Tax subunit dimerization. Amino acid residues around the trypsin- and chymotrypsin-sensitive sites (88KVL90) of Tax bear resemblance to those in the kinase-inducible domain of CREB (129SRRPSYRKILNE140) surrounding Ser-133, which undergoes signal-induced phosphorylation to recruit CBP/p300. Site-directed mutagenesis of residues in this domain (R82A, K85A, K88A, and V89A) resulted in proteins which failed to transactivate from the HTLV-1 LTR in vivo. These mutants (K85A, K88A, and V89A) bind CREB with similar affinities as wild-type Tax, yet interaction with CBP/p300 is abrogated in various biochemical assays, indicating that the recruitment of CBP/p300 is crucial for Tax transactivation. A Tax mutant, M47, defective in the COOH-terminal transactivation domain, continued to interact with CBP/p300, suggesting that interactions with additional cellular factors are required for proper Tax function. JF - Molecular and cellular biology AU - Harrod, R AU - Tang, Y AU - Nicot, C AU - Lu, H S AU - Vassilev, A AU - Nakatani, Y AU - Giam, C Z AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1998/09// PY - 1998 DA - September 1998 SP - 5052 EP - 5061 VL - 18 IS - 9 SN - 0270-7306, 0270-7306 KW - Cyclic AMP Response Element-Binding Protein KW - 0 KW - Gene Products, tax KW - Recombinant Fusion Proteins KW - Chloramphenicol O-Acetyltransferase KW - EC 2.3.1.28 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - AIDS/HIV KW - Chloramphenicol O-Acetyltransferase -- biosynthesis KW - HeLa Cells KW - Humans KW - Recombinant Fusion Proteins -- isolation & purification KW - Amino Acid Sequence KW - Recombinant Fusion Proteins -- chemistry KW - Binding Sites KW - Cloning, Molecular KW - Recombinant Fusion Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Polymerase Chain Reaction KW - Sequence Alignment KW - Transfection KW - Escherichia coli KW - Molecular Sequence Data KW - Repetitive Sequences, Nucleic Acid KW - Sequence Deletion KW - Protein Conformation KW - Gene Products, tax -- chemistry KW - Human T-lymphotropic virus 1 -- genetics KW - Gene Products, tax -- metabolism KW - Cyclic AMP Response Element-Binding Protein -- metabolism KW - Human T-lymphotropic virus 1 -- metabolism KW - Gene Products, tax -- isolation & purification KW - Cyclic AMP Response Element-Binding Protein -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73865246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=An+exposed+KID-like+domain+in+human+T-cell+lymphotropic+virus+type+1+Tax+is+responsible+for+the+recruitment+of+coactivators+CBP%2Fp300.&rft.au=Harrod%2C+R%3BTang%2C+Y%3BNicot%2C+C%3BLu%2C+H+S%3BVassilev%2C+A%3BNakatani%2C+Y%3BGiam%2C+C+Z&rft.aulast=Harrod&rft.aufirst=R&rft.date=1998-09-01&rft.volume=18&rft.issue=9&rft.spage=5052&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-10 N1 - Date created - 1998-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1996 Jul 25;382(6589):319-24 [8684459] J Virol. 1998 Aug;72(8):6777-84 [9658126] Nature. 1995 Mar 2;374(6517):81-4 [7870178] J Virol. 1995 Jun;69(6):3420-32 [7745688] J Virol. 1995 Aug;69(8):5077-86 [7609077] J Virol. 1995 Sep;69(9):5806-11 [7637025] Nature. 1995 Aug 17;376(6541):602-5 [7637811] Nature. 1995 Aug 17;376(6541):606-8 [7637812] J Biol Chem. 1995 Dec 1;270(48):28503-6 [7499359] Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415-9 [6261256] Proc Natl Acad Sci U S A. 1982 Mar;79(6):2031-5 [6979048] Proc Natl Acad Sci U S A. 1985 Jan;82(2):488-92 [3881765] Lancet. 1985 Aug 24;2(8452):407-10 [2863442] Ann Neurol. 1987 Feb;21(2):117-22 [2881513] Nature. 1989 Feb 23;337(6209):749-52 [2521922] Cell. 1989 Nov 17;59(4):675-80 [2573431] Genes Dev. 1989 Oct;3(10):1534-44 [2482226] Science. 1990 Mar 2;247(4946):1082-4 [2309119] Genes Dev. 1989 Dec;3(12B):2083-90 [2516827] Genes Dev. 1990 Nov;4(11):1875-85 [2276622] Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11445-9 [1763059] Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7070-4 [1386673] J Virol. 1992 Dec;66(12):7183-92 [1433511] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):610-4 [8421695] Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7303-7 [8346248] Nature. 1993 Oct 28;365(6449):855-9 [8413673] Science. 1993 Oct 15;262(5132):395-9 [8211160] EMBO J. 1993 Nov;12(11):4269-78 [8223437] Mol Cell Biol. 1994 Jan;14(1):456-62 [8264613] Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5642-6 [8202541] Cell. 1994 Jun 17;77(6):799-800 [8004670] Mol Cell Biol. 1994 Jul;14(7):4958-74 [8007991] Nature. 1994 Jul 21;370(6486):177-8 [8028657] Nature. 1994 Jul 21;370(6486):223-6 [7913207] Nature. 1994 Jul 21;370(6486):226-9 [8028671] Nucleic Acids Res. 1994 Aug 11;22(15):3194-201 [8065935] J Biol Chem. 1994 Sep 9;269(36):22466-9 [8077190] J Virol. 1995 Mar;69(3):1827-33 [7853523] Oncogene. 1995 Dec 21;11(12):2509-14 [8545107] Genes Dev. 1996 Mar 1;10(5):528-40 [8598284] Nature. 1996 Apr 18;380(6575):642-6 [8602268] Mol Cell Biol. 1996 May;16(5):2174-82 [8628284] EMBO J. 1996 May 1;15(9):2236-48 [8641289] Oncogene. 1996 May 2;12(9):1961-9 [8649857] Mol Cell Biol. 1996 Jun;16(6):3156-68 [8649426] Nature. 1996 Sep 5;383(6595):22-3 [8779707] J Virol. 1996 Nov;70(11):7478-84 [8892866] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13896-901 [8943032] Cell. 1996 Nov 29;87(5):953-9 [8945521] J Mol Biol. 1996 Nov 22;264(1):20-31 [8950264] Nature. 1996 Dec 19-26;384(6610):641-3 [8967953] J Virol. 1996 Dec;70(12):8368-74 [8970957] Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3662-7 [9108034] Mol Cell Biol. 1997 Sep;17(9):5156-64 [9271393] Mol Cell Biol. 1998 Feb;18(2):721-31 [9447968] Mol Cell Biol. 1998 Apr;18(4):2392-405 [9528808] J Virol. 1995 Mar;69(3):1834-41 [7853524] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Successful treatment of stutter priapism with an antiandrogen. AN - 70012971; 9800902 AB - Recurring periods of prolonged erections in patients with sickle cell disease (stutter priapism) are uncommon, yet troubling sequelae of hemoglobinopathies. Medical or surgical therapy is variably successful in these men. We report a case of stutter priapism successfully treated with an oral antiandrogen. JF - Techniques in urology AU - Costabile, R A AD - Urology Service, Walter Reed Army Medical Center, Uniformed Services University of the Health Sciences, Washington, DC 20307-5001, USA. Y1 - 1998/09// PY - 1998 DA - September 1998 SP - 167 EP - 168 VL - 4 IS - 3 SN - 1079-3259, 1079-3259 KW - Androgen Antagonists KW - 0 KW - Flutamide KW - 76W6J0943E KW - Leuprolide KW - EFY6W0M8TG KW - Index Medicus KW - Headache -- chemically induced KW - Gynecomastia -- radiotherapy KW - Humans KW - Adult KW - Treatment Outcome KW - Gynecomastia -- surgery KW - Gynecomastia -- chemically induced KW - Anemia, Sickle Cell -- complications KW - Radiotherapy KW - Mastectomy KW - Male KW - Leuprolide -- adverse effects KW - Priapism -- etiology KW - Androgen Antagonists -- adverse effects KW - Priapism -- drug therapy KW - Androgen Antagonists -- therapeutic use KW - Flutamide -- therapeutic use KW - Leuprolide -- therapeutic use KW - Flutamide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70012971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Techniques+in+urology&rft.atitle=Successful+treatment+of+stutter+priapism+with+an+antiandrogen.&rft.au=Costabile%2C+R+A&rft.aulast=Costabile&rft.aufirst=R&rft.date=1998-09-01&rft.volume=4&rft.issue=3&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Techniques+in+urology&rft.issn=10793259&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-01-12 N1 - Date created - 1999-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental Science & Technology, ES & T AN - 52111272; 2002-035758 JF - Environmental Science & Technology, ES & T AU - Ball, William P AU - Goltz, Mark N AU - Roberts, Paul V AU - Valocchi, Albert J AU - Brusseau, Mark L AU - Cushey, Mark A AU - Rubin, Yoram Y1 - 1998/09// PY - 1998 DA - September 1998 SP - 2654 EP - 2656 PB - American Chemical Society, Washington, DC VL - 32 IS - 17 SN - 0013-936X, 0013-936X KW - North America KW - sorption KW - Simcoe County Ontario KW - experimental studies KW - pollutants KW - pollution KW - migration of elements KW - simulation KW - equilibrium KW - Ontario KW - ground water KW - aquifers KW - models KW - laboratory studies KW - chemical reactions KW - Canada KW - transport KW - stochastic processes KW - Borden Ontario KW - mass transfer KW - Eastern Canada KW - Borden Aquifer KW - diffusivity KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52111272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Environmental+Science+%26amp%3B+Technology%2C+ES+%26amp%3B+T&rft.au=Ball%2C+William+P%3BGoltz%2C+Mark+N%3BRoberts%2C+Paul+V%3BValocchi%2C+Albert+J%3BBrusseau%2C+Mark+L%3BCushey%2C+Mark+A%3BRubin%2C+Yoram&rft.aulast=Ball&rft.aufirst=William&rft.date=1998-09-01&rft.volume=32&rft.issue=17&rft.spage=2654&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/ L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 33 N1 - PubXState - DC N1 - Document feature - illus. N1 - SuppNotes - For reference to original see Cushey, M. A., Rubin, Y., Environ. Sci. Technol., Vol. 31, p. 1259-1268, 1997 N1 - Last updated - 2012-06-07 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - aquifers; Borden Aquifer; Borden Ontario; Canada; chemical reactions; diffusivity; Eastern Canada; equilibrium; experimental studies; ground water; laboratory studies; mass transfer; migration of elements; models; North America; Ontario; pollutants; pollution; Simcoe County Ontario; simulation; sorption; stochastic processes; transport ER - TY - JOUR T1 - Immunization against natural Helicobacter pylori infection in nonhuman primates AN - 16506240; 4393895 AB - Helicobacter pylori infection is widespread in some breeding groups of a rhesus monkey colony (71% H. pylori positive by 1 year), and the rate of seroconversion is also high. As a result, these groups can be used to test the safety and efficacy of an anti-H. pylori vaccine. Nine-month-old female animals were randomized to receive either 8 mg of recombinant urease (rUre) plus 25 mu g of Escherichia coli heat-labile enterotoxin (LT) (n = 26) or placebo plus LT (n = 29), given four times at 1-week intervals followed by a booster 1 month later. Ten months after the start of the immunization, the animals were subjected to endoscopy and biopsy samples were obtained. H. pylori negativity was defined as no H. pylori growth by culture and no H. pylori observed at histology. By this criterion, 2 (7%) of 29 animals receiving placebo and 8 (31%) of 26 immunized animals were H. pylori negative (P < 0.035). In addition, antral gastritis score was significantly less in H. pylori-negative immunized monkeys than in H. pylori-positive animals, whether they were given rUre plus LT or placebo plus LT (P < 0.02 or P < 0.01, respectively). Interestingly, antral gastritis was also significantly less in H. pylori-positive animals given rUre plus LT than in H. pylori-positive animals given placebo plus LT (P < 0.02). However, quantitative cultures did not demonstrate significant differences between the two latter groups. It is concluded that oral administration of rUre vaccine plus LT significantly protects nonhuman primates against H. pylori infection while not causing undesirable side effects. JF - Infection and Immunity AU - Dubois, A AU - Lee, C K AU - Fiala, N AU - Kleanthous, H AU - Mehlman, P T AU - Monath, T AD - Department of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA, ADUBOIS@USUHS.MIL Y1 - 1998/09// PY - 1998 DA - Sep 1998 SP - 4340 EP - 4346 VL - 66 IS - 9 SN - 0019-9567, 0019-9567 KW - Helicobacter pylori KW - Macaca mulatta KW - Rhesus macaque KW - infection KW - oral administration KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16506240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Immunization+against+natural+Helicobacter+pylori+infection+in+nonhuman+primates&rft.au=Dubois%2C+A%3BLee%2C+C+K%3BFiala%2C+N%3BKleanthous%2C+H%3BMehlman%2C+P+T%3BMonath%2C+T&rft.aulast=Dubois&rft.aufirst=A&rft.date=1998-09-01&rft.volume=66&rft.issue=9&rft.spage=4340&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Asbestos fibers and interleukin-1 upregulate the formation of reactive nitrogen species in rat pleural mesothelial cells. AN - 80060330; 9698594 AB - Nitric oxide radical (.NO) and peroxynitrite anion (ONOO-) have been implicated in lung inflammation and may be important in pleural injury. The present study was undertaken to determine the effects of asbestos exposure and cytokine stimulation on .NO and ONOO- production by rat pleural mesothelial cells. Accordingly, rat parietal pleural mesothelial cells were cultured for 2 to 72 h with or without 50 ng/ml of recombinant interleukin-1beta (IL-1beta) in the presence (1.05 to 8.4 microg/cm2) or absence of crocidolite or chrysotile asbestos fibers. The effects of asbestos were compared with those of carbonyl iron, a nonfibrogenic particulate. Mesothelial cell messenger RNA (mRNA) expression of the inducible form of .NO synthase (iNOS), assessed with the reverse transcription-polymerase chain reaction (RT-PCR), increased progressively from 2 to 12 h in IL-1beta-containing cultures. Nitrite (NO2-), the stable oxidation product of .NO in mesothelial cell conditioned medium, was assayed through the Griess reaction. Both types of asbestos fibers (chrysotile > crocidolite) upregulated the formation of NO2- in mesothelial cells costimulated with IL-1beta in a concentration-dependent and time-dependent fashion. In contrast, carbonyl iron did not upregulate NO2- formation in IL-1beta-stimulated cells. Both types of asbestos fibers also induced iNOS protein expression and the formation of nitrotyrosine in mesothelial cells and greatly induced the formation of nitrate (NO3-), a surrogate marker of ONOO- formation, in IL-1beta-stimulated cells. However, the effects of chrysotile were notably greater than those of crocidolite. These findings may have significance for the induction of pleural injury by asbestos fibers. JF - American journal of respiratory cell and molecular biology AU - Choe, N AU - Tanaka, S AU - Kagan, E AD - Department of Pathology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, Maryland, USA. Y1 - 1998/08// PY - 1998 DA - August 1998 SP - 226 EP - 236 VL - 19 IS - 2 SN - 1044-1549, 1044-1549 KW - Culture Media, Conditioned KW - 0 KW - Free Radicals KW - Interleukin-1 KW - Nitrates KW - Recombinant Proteins KW - Asbestos KW - 1332-21-4 KW - peroxynitric acid KW - 26404-66-0 KW - Nitric Oxide KW - 31C4KY9ESH KW - Cytochalasin B KW - 3CHI920QS7 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type II KW - Nos2 protein, rat KW - Index Medicus KW - Animals KW - Recombinant Proteins -- pharmacology KW - Cytochalasin B -- pharmacology KW - Epithelium -- enzymology KW - Epithelium -- drug effects KW - Nitric Oxide Synthase -- biosynthesis KW - Rats KW - Rats, Inbred F344 KW - Cells, Cultured KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Nitric Oxide Synthase -- genetics KW - Enzyme Induction KW - Epithelium -- metabolism KW - Immunohistochemistry KW - L-Lactate Dehydrogenase -- metabolism KW - Interleukin-1 -- pharmacology KW - Pleura -- enzymology KW - Nitrates -- metabolism KW - Pleura -- drug effects KW - Pleura -- metabolism KW - Nitric Oxide -- biosynthesis KW - Asbestos -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80060330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Asbestos+fibers+and+interleukin-1+upregulate+the+formation+of+reactive+nitrogen+species+in+rat+pleural+mesothelial+cells.&rft.au=Choe%2C+N%3BTanaka%2C+S%3BKagan%2C+E&rft.aulast=Choe&rft.aufirst=N&rft.date=1998-08-01&rft.volume=19&rft.issue=2&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-03 N1 - Date created - 1998-09-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytoplasmic forms of human T-cell leukemia virus type 1 Tax induce NF-kappaB activation. AN - 79999888; 9658126 AB - Human T-cell leukemia virus type 1 (HTLV-1) Tax targets I-kappaB alpha and I-kappaB beta for phosphorylation, ubiquitination, and proteasome-mediated degradation, causing the nuclear translocation of NF-kappaB/Rel proteins and transcription induction of many cellular genes. The mechanism by which a nuclear protein such as Tax stimulates I-kappaB phosphorylation and degradation remains unclear. Here, we describe two cytoplasmic mutants of Tax, designated TaxDeltaN81 and TaxDeltaN109, from which the domains important for cyclic AMP response element binding factor (CREB) and serum response factor (SRF) binding and nuclear transport have been removed. These mutants were unable to trans activate from the HTLV-1 21-bp repeats or the serum response element in the c-fos promoter. In contrast, they activated NF-kappaB reporters, suggesting that activation of NF-kappaB by Tax occurs in the cytoplasm. Incorporation of the nuclear localization signal (NLS) of the simian virus 40 large T antigen into TaxDeltaN81 and TaxDeltaN109 redirected both proteins predominantly to the nucleus yet did not restore trans activation via CREB or SRF. The NLS fusion had little effect on TaxDeltaN81 but reduced NF-kappaB trans activation by TaxDeltaN109, possibly because of its proximity to the NF-kappaB-activating domain of Tax. In contrast to wild-type Tax, the cytoplasmic TaxDeltaN mutants are not cytotoxic. Stable expression of TaxDeltaN109 in HeLa cells resulted in a significant reduction in the intracellular level of I-kappaB alpha, with the constitutive presence of NF-kappaB in the nucleus and concomitant activation of the NF-kappaB enhancer. These results are suggestive of a potential application of the TaxDeltaN109-like mutants in targeting I-kappaB degradation and NF-kappaB activation. Interestingly, a Tax species with a molecular mass similar to that of TaxDeltaN109 was identified in many HTLV-1-transformed T cells, suggesting that TaxDeltaN109-like species might play a role in HTLV-1-induced leukemogenesis. JF - Journal of virology AU - Nicot, C AU - Tie, F AU - Giam, C Z AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1998/08// PY - 1998 DA - August 1998 SP - 6777 EP - 6784 VL - 72 IS - 8 SN - 0022-538X, 0022-538X KW - Gene Products, tax KW - 0 KW - NF-kappa B KW - Index Medicus KW - AIDS/HIV KW - Phenotype KW - HeLa Cells KW - Cytoplasm -- metabolism KW - Humans KW - Gene Expression KW - Cell Line, Transformed KW - Chromosome Mapping KW - Transcriptional Activation KW - Mutagenesis KW - Binding Sites KW - Gene Products, tax -- metabolism KW - Human T-lymphotropic virus 1 -- metabolism KW - Gene Products, tax -- genetics KW - NF-kappa B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79999888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Cytoplasmic+forms+of+human+T-cell+leukemia+virus+type+1+Tax+induce+NF-kappaB+activation.&rft.au=Nicot%2C+C%3BTie%2C+F%3BGiam%2C+C+Z&rft.aulast=Nicot&rft.aufirst=C&rft.date=1998-08-01&rft.volume=72&rft.issue=8&rft.spage=6777&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-08-05 N1 - Date created - 1998-08-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1995 Mar;69(3):1834-41 [7853524] Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7070-4 [1386673] Science. 1995 Mar 10;267(5203):1485-8 [7878466] Annu Rev Cell Biol. 1994;10:405-55 [7888182] Oncogene. 1995 Mar 16;10(6):1199-207 [7700645] Biochem J. 1995 Apr 1;307 ( Pt 1):287-95 [7717987] Mol Cell Biol. 1995 May;15(5):2689-96 [7739549] Mol Cell Biol. 1995 May;15(5):2809-18 [7739562] J Biol Chem. 1995 May 19;270(20):11745-8 [7744820] Genes Dev. 1995 Jul 1;9(13):1586-97 [7628694] Oncogene. 1992 Sep;7(9):1737-42 [1501885] Genes Dev. 1992 Nov;6(11):2066-76 [1427072] Cancer Surv. 1992;15:69-87 [1451115] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):610-4 [8421695] Science. 1993 Mar 26;259(5103):1912-5 [8096091] Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7303-7 [8346248] Curr Opin Cell Biol. 1993 Jun;5(3):477-87 [8352966] Nucleic Acids Res. 1993 Aug 11;21(16):3799-807 [8367298] Science. 1993 Oct 15;262(5132):395-9 [8211160] Genes Dev. 1993 Nov;7(11):2064-70 [8224838] J Virol. 1994 May;68(5):3374-9 [8151796] J Infect Dis. 1994 Mar;169(3):496-503 [8158021] Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3584-8 [8170951] Mol Cell Biol. 1994 Oct;14(10):6443-51 [7935369] Mol Cell Biol. 1994 Nov;14(11):7377-84 [7935451] Oncogene. 1994 Nov;9(11):3099-105 [7936632] J Virol. 1995 Jan;69(1):564-9 [7983756] Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12634-8 [7809091] Oncogene. 1995 Jan 19;10(2):269-77 [7838527] Immunity. 1995 Sep;3(3):263-72 [7552992] Genes Dev. 1995 Nov 15;9(22):2736-46 [7590249] EMBO J. 1996 Feb 15;15(4):873-87 [8631308] J Virol. 1996 May;70(5):2730-5 [8627746] Nature. 1996 Apr 18;380(6575):642-6 [8602268] Mol Cell Biol. 1996 May;16(5):2083-90 [8628274] Mol Cell Biol. 1996 May;16(5):2341-9 [8628301] Nature. 1996 May 23;381(6580):328-31 [8692272] Annu Rev Immunol. 1996;14:649-83 [8717528] Cell. 1996 Oct 4;87(1):13-20 [8858144] Virology. 1996 Nov 1;225(1):52-64 [8918533] J Virol. 1996 Dec;70(12):8368-74 [8970957] Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415-9 [6261256] Proc Natl Acad Sci U S A. 1981 Oct;78(10):6476-80 [7031654] Nature. 1984 Jun 14-20;309(5969):640-2 [6328324] Science. 1985 Mar 8;227(4691):1227-8 [2983419] Lancet. 1985 Aug 24;2(8452):407-10 [2863442] Cell. 1986 Aug 15;46(4):575-82 [3015419] Ann Neurol. 1987 Feb;21(2):117-22 [2881513] J Biol Chem. 1987 Jul 25;262(21):10035-8 [3611052] J Biol Chem. 1989 Sep 15;264(26):15236-41 [2768259] Nucleic Acids Res. 1989 Aug 11;17(15):6420 [2771660] Genes Dev. 1989 Oct;3(10):1534-44 [2482226] Nucleic Acids Res. 1990 Jun 25;18(12):3587-96 [2194165] Genes Dev. 1990 Nov;4(11):1875-85 [2276622] J Virol. 1992 Jan;66(1):139-49 [1727476] Cell. 1991 Dec 20;67(6):1075-87 [1760839] Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11445-9 [1763059] Virology. 1992 Mar;187(1):316-20 [1736534] Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3005-9 [1348363] Cell. 1995 Feb 24;80(4):573-82 [7867065] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational Upper-Extremity-Related Disability: Demographic, Physical, and Psychosocial Factors AN - 17098295; 4403724 AB - Occupational upper-extremity disorders have been associated with prolonged pain and work disability. Using the U.S. Army Physical Disability Agency database, the present case-control studies (n = 434 and n = 342) investigated the contribution of demographic, physical, occupational psychosocial, and individual psychosocial factors to work disability in soldiers with upper-extremity disorders. Age (odds ratio [OR] = 1.11), rank (private E-2: OR = 3.79; private first class: OR = 4.39; specialist or corporal: OR = 2.17), ethnic group (white: OR = 1.54), and occupational stress ("often": OR = 2.46) were found to predict disability. The results highlight the importance of occupational stress as a predictor of disability and the potential utility of addressing this factor in the development of empirically based disability prevention strategies. This investigation also emphasizes the need for research that delineates the biobehavioral mechanisms linking occupational stress to prolonged symptoms and subsequent work disability. JF - Military Medicine AU - Huang, G D AU - Feuerstein, M AU - Berkowitz, S M AU - Peck, CA Jr AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA Y1 - 1998/08// PY - 1998 DA - Aug 1998 SP - 552 EP - 558 VL - 163 IS - 8 SN - 0026-4075, 0026-4075 KW - disabilities KW - extremities KW - Health & Safety Science Abstracts KW - Stress KW - Military KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17098295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Medicine&rft.atitle=Occupational+Upper-Extremity-Related+Disability%3A+Demographic%2C+Physical%2C+and+Psychosocial+Factors&rft.au=Huang%2C+G+D%3BFeuerstein%2C+M%3BBerkowitz%2C+S+M%3BPeck%2C+CA+Jr&rft.aulast=Huang&rft.aufirst=G&rft.date=1998-08-01&rft.volume=163&rft.issue=8&rft.spage=552&rft.isbn=&rft.btitle=&rft.title=Military+Medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational health; Stress; Military ER - TY - JOUR T1 - Pulmonary and hepatic gene expression following cecal ligation and puncture: Monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration AN - 16490072; 4392125 AB - Polymicrobial sepsis induced by cecal ligation and puncture (CLP) reproduces many of the pathophysiologic features of septic shock. In this study, we demonstrate that mRNA for a broad range of pro- and antiinflammatory cytokine and chemokine genes are temporally regulated after CLP in the lung and liver. We also assessed whether prophylactic administration of monophosphoryl lipid A (MPL), a nontoxic derivative of lipopolysaccharide (LPS) that induces endotoxin tolerance and attenuates the sepsis syndrome in mice after CLP, would alter tissue-specific gene expression post-CLP. Levels of pulmonary interleukin-6 (IL-6), tumor necrosis factor alpha (TNF- alpha ), granulocyte colony-stimulating factor (G-CSF), IL-1 receptor antagonist (IL-1ra), and IL-10 mRNA, as well as hepatic IL-1 beta , IL-6, gamma interferon (IFN- gamma ), G-CSF, inducible nitric oxide synthase, and IL-10 mRNA, were reduced in MPL-pretreated mice after CLP compared to control mice. Chemokine mRNA expression was also profoundly mitigated in MPL-pretreated mice after CLP. Specifically, levels of pulmonary and hepatic macrophage inflammatory protein 1 alpha (MIP-1 alpha ), MIP-1 beta , MIP-2, and monocyte chemoattractant protein-1 (MCP-1) mRNA, as well as hepatic IFN- gamma -inducible protein 10 and KC mRNA, were attenuated in MPL-pretreated mice after CLP. Attenuated levels of IL-6, TNF- alpha , MCP-1, MIP-1 alpha , and MIP-2 in serum also were observed in MPL-pretreated mice after CLP. Diminished pulmonary chemokine mRNA production was associated with reduced neutrophil margination and pulmonary myeloperoxidase activity. These data suggest that prophylactic administration of MPL mitigates the sepsis syndrome by reducing chemokine production and the recruitment of inflammatory cells into tissues, thereby attenuating the production of proinflammatory cytokines. JF - Infection and Immunity AU - Salkowski, CA AU - Detore, G AU - Franks, A AU - Falk, M C AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA, vogel@usuhsb.usuhs.mil Y1 - 1998/08// PY - 1998 DA - Aug 1998 SP - 3569 EP - 3578 VL - 66 IS - 8 SN - 0019-9567, 0019-9567 KW - gamma -Interferon KW - interleukin 1 receptor antagonist KW - lipopolysaccharides KW - macrophage inflammatory protein 1 alpha KW - monocyte chemoattractant protein 1 KW - monophosphoryl lipid A KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16490072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Pulmonary+and+hepatic+gene+expression+following+cecal+ligation+and+puncture%3A+Monophosphoryl+lipid+A+prophylaxis+attenuates+sepsis-induced+cytokine+and+chemokine+expression+and+neutrophil+infiltration&rft.au=Salkowski%2C+CA%3BDetore%2C+G%3BFranks%2C+A%3BFalk%2C+M+C%3BVogel%2C+S+N&rft.aulast=Salkowski&rft.aufirst=CA&rft.date=1998-08-01&rft.volume=66&rft.issue=8&rft.spage=3569&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Asbestos inhalation induces reactive nitrogen species and nitrotyrosine formation in the lungs and pleura of the rat. AN - 80007347; 9664087 AB - To determine whether asbestos inhalation induces the formation of reactive nitrogen species, three groups of rats were exposed intermittently over 2 wk to either filtered room air (sham-exposed) or to chrysotile or crocidolite asbestos fibers. The rats were killed at 1 or 6 wk after exposure. At 1 wk, significantly greater numbers of alveolar and pleural macrophages from asbestos-exposed rats than from sham-exposed rats demonstrated inducible nitric oxide synthase protein immunoreactivity. Alveolar macrophages from asbestos-exposed rats also generated significantly greater nitrite formation than did macrophages from sham-exposed rats. Strong immunoreactivity for nitrotyrosine, a marker of peroxynitrite formation, was evident in lungs from chrysotile- and crocidolite-exposed rats at 1 and 6 wk. Staining was most evident at alveolar duct bifurcations and within bronchiolar epithelium, alveolar macrophages, and the visceral and parietal pleural mesothelium. Lungs from sham-exposed rats demonstrated minimal immunoreactivity for nitrotyrosine. Significantly greater quantities of nitrotyrosine were detected by ELISA in lung extracts from asbestos-exposed rats than from sham-exposed rats. These findings suggest that asbestos inhalation can induce inducible nitric oxide synthase activation and peroxynitrite formation in vivo, and provide evidence of a possible alternative mechanism of asbestos-induced injury to that thought to be induced by Fenton reactions. JF - The Journal of clinical investigation AU - Tanaka, S AU - Choe, N AU - Hemenway, D R AU - Zhu, S AU - Matalon, S AU - Kagan, E AD - Department of Pathology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, Maryland 20814-4799, USA. Y1 - 1998/07/15/ PY - 1998 DA - 1998 Jul 15 SP - 445 EP - 454 VL - 102 IS - 2 SN - 0021-9738, 0021-9738 KW - Asbestos, Serpentine KW - 0 KW - Nitrates KW - Reactive Oxygen Species KW - Asbestos, Crocidolite KW - 12001-28-4 KW - peroxynitric acid KW - 26404-66-0 KW - Tyrosine KW - 42HK56048U KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type II KW - Nos2 protein, rat KW - Nitrogen Dioxide KW - S7G510RUBH KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Pleural Effusion KW - Pleura KW - Nitrogen Dioxide -- metabolism KW - Animals KW - Rats, Inbred F344 KW - Cells, Cultured KW - Enzyme-Linked Immunosorbent Assay KW - Bronchoalveolar Lavage KW - Male KW - Nitric Oxide Synthase -- biosynthesis KW - Reactive Oxygen Species -- metabolism KW - Nitrates -- metabolism KW - Lung -- metabolism KW - Lung -- pathology KW - Macrophages -- drug effects KW - Macrophages, Alveolar -- drug effects KW - Macrophages, Alveolar -- metabolism KW - Asbestos, Serpentine -- toxicity KW - Inhalation Exposure KW - Lung -- drug effects KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives KW - Asbestos, Crocidolite -- toxicity KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80007347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Asbestos+inhalation+induces+reactive+nitrogen+species+and+nitrotyrosine+formation+in+the+lungs+and+pleura+of+the+rat.&rft.au=Tanaka%2C+S%3BChoe%2C+N%3BHemenway%2C+D+R%3BZhu%2C+S%3BMatalon%2C+S%3BKagan%2C+E&rft.aulast=Tanaka&rft.aufirst=S&rft.date=1998-07-15&rft.volume=102&rft.issue=2&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-08-20 N1 - Date created - 1998-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Free Radic Res. 1995 Oct;23(4):371-8 [7493043] Eur J Immunol. 1995 Apr;25(4):947-51 [7737298] Exp Toxicol Pathol. 1995 May;47(2-3):207-11 [7580110] Arch Biochem Biophys. 1996 Feb 1;326(1):152-7 [8579364] FEBS Lett. 1996 Apr 29;385(1-2):63-6 [8641468] Am J Public Health. 1996 Feb;86(2):179-86 [8633733] Am J Respir Cell Mol Biol. 1996 Jul;15(1):141-7 [8679218] Arch Biochem Biophys. 1996 Sep 1;333(1):42-8 [8806752] Arch Biochem Biophys. 1996 Sep 1;333(1):282-90 [8806782] Cancer Invest. 1996;14(5):466-80 [8816862] Free Radic Biol Med. 1996;21(2):125-31 [8818626] Circulation. 1996 Oct 1;94(7):1665-73 [8840859] Am J Ind Med. 1996 Sep;30(3):252-66 [8876792] J Clin Invest. 1996 Nov 1;98(9):2050-9 [8903324] Am J Respir Crit Care Med. 1996 Nov;154(5):1511-9 [8912773] Am J Pathol. 1996 Dec;149(6):2005-22 [8952535] J Biol Chem. 1997 Jan 17;272(3):1433-6 [8999808] Am J Respir Cell Mol Biol. 1997 Feb;16(2):105-9 [9032115] J Pediatr Surg. 1997 Feb;32(2):275-82 [9044137] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3211-6 [9096372] Am J Respir Crit Care Med. 1997 May;155(5):1763-9 [9154889] J Neurochem. 1997 Nov;69(5):1945-53 [9349539] Environ Health Perspect. 1997 Sep;105 Suppl 5:1257-60 [9400734] Biochem J. 1998 Mar 1;330 ( Pt 2):795-801 [9480893] Biochemistry. 1966 Nov;5(11):3582-9 [5339594] Am Rev Respir Dis. 1981 Jun;123(6):670-9 [6267971] Arch Pathol Lab Med. 1982 Oct 8;106(11):544-96 [6897166] Environ Res. 1983 Dec;32(2):382-97 [6315391] Clin Exp Immunol. 1984 Mar;55(3):643-50 [6608427] Br J Exp Pathol. 1984 Aug;65(4):467-84 [6087872] Ann Allergy. 1985 Jun;54(6):464-73 [3893229] Biochem Biophys Res Commun. 1988 Jul 15;154(1):332-8 [3395336] Am Rev Respir Dis. 1988 Aug;138(2):278-83 [3143284] Biochem J. 1989 Feb 1;257(3):845-51 [2784672] Am Rev Respir Dis. 1990 May;141(5 Pt 1):1266-71 [2160214] Cancer Res. 1990 Aug 15;50(16):5153-63 [2165857] Thorax. 1990 Sep;45(9):649-54 [2218970] J Biol Chem. 1991 Mar 5;266(7):4244-50 [1847917] Biochim Biophys Acta. 1992 Feb 17;1104(1):87-94 [1550856] Carcinogenesis. 1992 Apr;13(4):637-42 [1315628] Toxicol Pathol. 1991;19(4 Pt 1):412-8 [1667555] Arch Biochem Biophys. 1992 Nov 1;298(2):446-51 [1329657] J Immunol. 1993 May 1;150(9):4188-96 [8473757] Am J Respir Cell Mol Biol. 1993 Oct;9(4):371-7 [7691109] FEBS Lett. 1994 Mar 14;341(1):65-8 [8137924] Biol Chem Hoppe Seyler. 1994 Feb;375(2):81-8 [8192861] Am J Physiol. 1994 Jun;266(6 Pt 1):L628-34 [8023951] Am J Physiol. 1994 Sep;267(3 Pt 1):L242-9 [7943250] Am J Respir Cell Mol Biol. 1994 Dec;11(6):707-15 [7524571] J Clin Invest. 1994 Dec;94(6):2407-13 [7989597] J Leukoc Biol. 1994 Dec;56(6):759-68 [7527832] Mutat Res. 1995 Oct;331(2):197-204 [7500978] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intravenous delivery of 5'-iododeoxyuridine during hyperfractionated radiotherapy for locally advanced head and neck cancers: results of a pilot study. AN - 85405309; pmid-9665262 AB - OBJECTIVES: Locally advanced cancers of the head and neck require aggressive treatment, often with limited effectiveness and significant toxicity and morbidity. This pilot study was designed to assess tolerance using combined hyperfractionated radiotherapy and the halogenated pyrimidine radiosensitizer 5'-iododeoxyuridine (IdUrd). STUDY DESIGN: This was a prospective single-arm study open to patients with advanced head and neck cancers that had a poor chance of control with conventional radiation therapy. Patients were treated with hyperfractionated radiation therapy at standard doses in combination with an IdUrd infusion and observed for tumor response and normal tissue tolerances. METHODS: Radiation therapy was delivered in fractions of 1.2 Gy or 1.5 Gy twice daily to a total dose in the range of 70 to 76 Gy. IdUrd was delivered as an intravenous infusion (1000 mg/m2 per day) for a maximum of 14 days at the beginning and then again during the middle of the radiotherapy. RESULTS: Twelve patients with advanced squamous cell lesions were enrolled and 11 were observed to have complete clinical remissions. Seven patients remained clinically free of local disease at the time of death or most recent follow-up. Acute toxicities, usually hematologic or mucosal, were severe and all patients required treatment modifications and considerable supportive care. CONCLUSIONS: Although a high rate of response was achieved using this regimen, the toxicities are prohibitive. The kinetic profile of IdUrd incorporation suggests the need for future studies using repetitive short courses of IdUrd. JF - The Laryngoscope AU - Epstein, A H AU - Lebovics, R S AU - Van Waes, C AU - Smith, J AU - Okunieff, P AU - Cook, J A AD - Department of Radiology and Nuclear Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 1998/07// PY - 1998 DA - July 1998 SP - 1090 EP - 1094 VL - 108 IS - 7 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Radiation Dosage KW - Disease-Free Survival KW - Prospective Studies KW - Combined Modality Therapy KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Pilot Projects KW - Male KW - Female KW - Remission Induction KW - Dose Fractionation KW - Head and Neck Neoplasms -- radiotherapy KW - Idoxuridine -- therapeutic use KW - Carcinoma, Squamous Cell -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Head and Neck Neoplasms -- drug therapy KW - Radiation-Sensitizing Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85405309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Intravenous+delivery+of+5%27-iododeoxyuridine+during+hyperfractionated+radiotherapy+for+locally+advanced+head+and+neck+cancers%3A+results+of+a+pilot+study.&rft.au=Epstein%2C+A+H%3BLebovics%2C+R+S%3BVan+Waes%2C+C%3BSmith%2C+J%3BOkunieff%2C+P%3BCook%2C+J+A&rft.aulast=Epstein&rft.aufirst=A&rft.date=1998-07-01&rft.volume=108&rft.issue=7&rft.spage=1090&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Inhibition of the cytotoxicity of protein toxins by a novel plant metabolite, mansonone-D. AN - 79917980; 9618143 AB - We have studied the effect of several structurally related mansonones on the cytotoxicity of plant and bacterial toxins in Vero and BER-40, a brefeldin A-resistant mutant of Vero cells. Mansonone-D (MD), a sesquiterpenoid ortho-naphthoquinone, inhibited the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in Vero cells to different extents. The inhibition of ricin cytotoxicity was dose dependent and reversed upon removal of the drug. Protection of ricin cytotoxicity was also observed in the presence of cycloheximide, indicating that de novo protein synthesis is not required for the protective effect. Although MD inhibited the degradation and excretion of ricin, the binding and internalization of ricin was not affected. In contrast, MD strongly reduced the specific binding of diphtheria toxin in Vero cells. Fluorescence microscopic studies show that MD treatment dramatically alters the morphology of the Golgi apparatus in Vero cells. The kinetic studies reveal that the protection of ricin cytotoxicity is the consequence of decreased toxin translocation to the cytosol in MD-treated cells. The reactive ortho-quinone moiety of MD is important for the protective effect as thespesone, a para-naphthoquinone with a heterocyclic ring structure identical to that of MD, did not inhibit the cytotoxicity of toxins. Thespone, a dehydromansonone-D, lacking two hydrogens from the heterocyclic dihydrofuran ring of MD, inhibited the cytotoxicity of ricin, but was albeit less potent than MD. Neither mansonone-E nor mansonone-H with reactive ortho-quinone moiety, but with a different heterocyclic structure, had any effect on the cytotoxicity of ricin indicating that the protective effect of MD is specifically related to the overall structure of the metabolite. JF - Journal of cellular physiology AU - Nambiar, M P AU - Murugesan, R AU - Wu, H C AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. gopi@helix.nih.gov Y1 - 1998/07// PY - 1998 DA - July 1998 SP - 40 EP - 49 VL - 176 IS - 1 SN - 0021-9541, 0021-9541 KW - Antitoxins KW - 0 KW - Diphtheria Toxin KW - Naphthoquinones KW - Plant Extracts KW - Plant Lectins KW - Sesquiterpenes KW - Toxins, Biological KW - mansonone D KW - Ricin KW - 9009-86-3 KW - Cycloheximide KW - 98600C0908 KW - Index Medicus KW - Molecular Structure KW - Animals KW - Golgi Apparatus -- drug effects KW - Diphtheria Toxin -- metabolism KW - Diphtheria Toxin -- antagonists & inhibitors KW - Microscopy, Fluorescence KW - Plants -- chemistry KW - Ricin -- antagonists & inhibitors KW - Ricin -- metabolism KW - Protein Binding -- drug effects KW - Cycloheximide -- pharmacology KW - Kinetics KW - Cercopithecus aethiops KW - Endocytosis -- drug effects KW - Vero Cells KW - Immunohistochemistry KW - Antitoxins -- pharmacology KW - Plant Extracts -- pharmacology KW - Toxins, Biological -- toxicity KW - Naphthoquinones -- pharmacology KW - Sesquiterpenes -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79917980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Inhibition+of+the+cytotoxicity+of+protein+toxins+by+a+novel+plant+metabolite%2C+mansonone-D.&rft.au=Nambiar%2C+M+P%3BMurugesan%2C+R%3BWu%2C+H+C&rft.aulast=Nambiar&rft.aufirst=M&rft.date=1998-07-01&rft.volume=176&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-01 N1 - Date created - 1998-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational upper extremity disorders in the federal workforce. Prevalence, health care expenditures, and patterns of work disability. AN - 79955315; 9636935 AB - Upper extremity disorders (UEDs) account for a significant number of work-related illnesses in the US workforce. Little information exists on the distribution of UEDs, their associated health care and indemnity costs, or patterns of work disability. The study presented is an analysis of upper extremity claims within the federal workforce. In this study, the universe consisted of all claims accepted by the US Department of Labor, Office of Workers' Compensation Programs (OWCP), from October 1, 1993, through September 30, 1994. A total of 185,927 claims of notices of injury were processed during the study period, and of these, 8,147 or 4.4% had an UED diagnosis coded according to the International Classification of Diseases, Clinical Modification (ICD-9-CM). 5,844 claims involved a single UED diagnosis and were the only claims field by these employees between October 1, 1990, and September 30, 1994. These single claims with single diagnoses comprised the sample for further analysis. Mononeuritis and enthesopathies of the upper limb were the most common diagnoses, accounting for 43% and 31% of the claims, respectively. Women had a higher proportion of carpal tunnel syndrome, "unspecified" mononeuritis, and "unspecified" enthesopathies. The majority of claimants for both the mononeuritis- and enthesopathy-related diagnoses were between 31 and 50 years of age, received only health care benefits, and did not incur wage loss. Health care costs for mononeuritis and enthesopathy claims were $12,228,755 (M = $2,849). Carpal tunnel syndrome (CTS) and enthesopathy of the elbow were the most costly diagnoses, accounting for 57% and 16% of the total, respectively. Surgical services represented the highest expenditures in CTS claims. Physical therapy accounted for the majority of health care costs for enthesopathy cases. The mean number of workdays lost for CTS and enthesopathy claims were 84 and 79, and the average indemnity costs were $4,941 and $4,477, respectively. These findings indicate that while UEDs represent a relatively small percentage of all workers' compensation cases, the health care and indemnity costs are considerable. Also mean duration and pattern of work disability revealed that these disorders can result in chronic work disability similar to that observed in low back pain. The results highlight the need to determine whether interventions that account for the majority of costs significantly impact long-term outcomes. There is also a need to identify risk factors for prolonged disability in those who experience problems with delayed recovery. JF - Journal of occupational and environmental medicine AU - Feuerstein, M AU - Miller, V L AU - Burrell, L M AU - Berger, R AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 1998/06// PY - 1998 DA - June 1998 SP - 546 EP - 555 VL - 40 IS - 6 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - Cost of Illness KW - Risk Factors KW - Humans KW - Health Expenditures -- statistics & numerical data KW - Chi-Square Distribution KW - Adult KW - Middle Aged KW - Insurance Claim Review KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Workers' Compensation -- economics KW - Arm Injuries -- epidemiology KW - Occupational Diseases -- economics KW - Arm Injuries -- economics KW - Cumulative Trauma Disorders -- economics KW - Occupational Diseases -- epidemiology KW - Workers' Compensation -- statistics & numerical data KW - Cumulative Trauma Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79955315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Occupational+upper+extremity+disorders+in+the+federal+workforce.+Prevalence%2C+health+care+expenditures%2C+and+patterns+of+work+disability.&rft.au=Feuerstein%2C+M%3BMiller%2C+V+L%3BBurrell%2C+L+M%3BBerger%2C+R&rft.aulast=Feuerstein&rft.aufirst=M&rft.date=1998-06-01&rft.volume=40&rft.issue=6&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-24 N1 - Date created - 1998-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Probability distribution of surface elevation in surf and swash zones AN - 52596182; 1998-038259 JF - Journal of Waterway, Port, Coastal and Ocean Engineering AU - Kobayashi, Nobuhisa AU - Herrman, Michael N AU - Johnson, Bradley D AU - Orzech, Mark D Y1 - 1998/06// PY - 1998 DA - June 1998 SP - 99 EP - 107 PB - American Society of Civil Engineers, Waterway, Port, Coastal and Ocean Division, New York, NY VL - 124 IS - 3 SN - 0733-950X, 0733-950X KW - beaches KW - shore features KW - experimental studies KW - waves KW - shoaling KW - statistical analysis KW - shorelines KW - probability KW - distribution KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52596182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Waterway%2C+Port%2C+Coastal+and+Ocean+Engineering&rft.atitle=Probability+distribution+of+surface+elevation+in+surf+and+swash+zones&rft.au=Kobayashi%2C+Nobuhisa%3BHerrman%2C+Michael+N%3BJohnson%2C+Bradley+D%3BOrzech%2C+Mark+D&rft.aulast=Kobayashi&rft.aufirst=Nobuhisa&rft.date=1998-06-01&rft.volume=124&rft.issue=3&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+Waterway%2C+Port%2C+Coastal+and+Ocean+Engineering&rft.issn=0733950X&rft_id=info:doi/ L2 - http://scitation.aip.org/wwo LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 39 N1 - PubXState - NY N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - JWPED5 N1 - SubjectsTermNotLitGenreText - beaches; distribution; experimental studies; probability; shoaling; shore features; shorelines; statistical analysis; waves ER - TY - JOUR T1 - Objective Diagnosis of Binary Tropical Cyclone Interactions for the Western North Pacific Basin AN - 17274548; 4392937 AB - Objective criteria for distinguishing among three modes of binary tropical cyclone (TC) interactions (TCI) are defined and tested with an eight-year sample of western North Pacific TCs. These objective criteria lead to an approximate 4:1 ratio of hits to misses of the subjectively assigned TCIs. False alarm rates of approximately 20% are also found, which indicate that similar track deflections may occur for other reasons, and the objective identifications must still be carefully validated by a forecaster. JF - Monthly Weather Review AU - Carr, LE III AU - Elsberry, R L AD - Department of Meteorology, Naval Postgraduate School, Code MR/Cr, 589 Dyer Rd., Monterey, CA 93943-5114, USA, carrleps.navy.mil Y1 - 1998/06// PY - 1998 DA - Jun 1998 SP - 1734 EP - 1740 VL - 126 IS - 6 SN - 0027-0644, 0027-0644 KW - North Pacific Ocean KW - ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Cyclones KW - Marine KW - Tropical meteorology KW - Tropical regions KW - Basins KW - INW, North Pacific KW - Oceans KW - Ocean-atmosphere system KW - Weather forecasting KW - Q2 09243:Structure, mechanics and thermodynamics KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17274548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Monthly+Weather+Review&rft.atitle=Objective+Diagnosis+of+Binary+Tropical+Cyclone+Interactions+for+the+Western+North+Pacific+Basin&rft.au=Carr%2C+LE+III%3BElsberry%2C+R+L&rft.aulast=Carr&rft.aufirst=LE&rft.date=1998-06-01&rft.volume=126&rft.issue=6&rft.spage=1734&rft.isbn=&rft.btitle=&rft.title=Monthly+Weather+Review&rft.issn=00270644&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Cyclones; Tropical meteorology; Oceans; Ocean-atmosphere system; Basins; Weather forecasting; Tropical regions; INW, North Pacific; Marine ER - TY - JOUR T1 - Sudden death in young athletes: Screening for the needle in a haystack AN - 16555180; 4397114 AB - Nontraumatic sudden death in young athletes is always disturbing, as apparently invincible athletes, become, without warning, victims of silent heart disease. Despite public perception to the contrary, sudden death in young athletes is exceedingly rare. It most commonly occurs in male athletes, who have estimated death rates nearly fivefold greater than the rates of female athletes. Congenital cardiovascular disease is the leading cause of nontraumatic sudden athletic death, with hypertrophic cardiomyopathy being the most common cause. Screening athletes for disorders capable of provoking sudden death is a challenge because of the low prevalence of disease, and the cost and limitations of available screening tests. Current recommendations for cardiovascular screening call for a careful history and physical examination performed by a knowledgeable health care provider. Specialized testing is recommended only in cases that warrant further evaluation. JF - American Family Physician AU - O'Connor, F G AU - Kugler, J P AU - Oriscello, R G AD - Uniformed Services University of the Health Sciences, Bethesda, MD, USA Y1 - 1998/06// PY - 1998 DA - Jun 1998 SP - 2763 EP - 2774 VL - 57 IS - 11 KW - athletes KW - Health & Safety Science Abstracts KW - Mortality KW - Health care KW - Diseases KW - Cardiovascular diseases KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16555180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Family+Physician&rft.atitle=Sudden+death+in+young+athletes%3A+Screening+for+the+needle+in+a+haystack&rft.au=O%27Connor%2C+F+G%3BKugler%2C+J+P%3BOriscello%2C+R+G&rft.aulast=O%27Connor&rft.aufirst=F&rft.date=1998-06-01&rft.volume=57&rft.issue=11&rft.spage=2763&rft.isbn=&rft.btitle=&rft.title=American+Family+Physician&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mortality; Cardiovascular diseases; Diseases; Health care ER - TY - JOUR T1 - Americans with Disabilities Act litigation and musculoskeletal-related impairments: Implications for work re-entry AN - 16437314; 4336388 AB - The Americans with Disabilities Act (ADA) was designed, in part, to assist in work re-entry for the disabled. ADA-related complaints that are more difficult to resolve and consequently reach the litigation stage may provide useful insights into the challenges associated with the re-integration of disabled workers into the workplace. The present study identified patterns of impairments and areas of dispute from all ADA litigation (n = 189) between 1990 to 1996. While HIV/AIDS was the most common single impairment category (18.8%), combined musculoskeletal-related (i.e., back and upper extremity) impairments comprised the largest group of impairments (23.4% of total) involved in litigation. The top two areas of dispute were termination and alleged failure to provide reasonable accommodation, respectively. The distribution of musculoskeletal- and nonmusculoskeletal-related cases were similar for these two areas of dispute. These findings highlight the direction upon which effective work re-entry strategies for workers with musculoskeletal-related disabilities must focus. Efforts to provide effective accommodation for these workers should improve return-to-work outcomes and reduce the risk of litigation. Specific recommendations for such efforts are provided. JF - Journal of Occupational Rehabilitation AU - Huang, G D AU - Feuerstein, M AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA, mfeuerst@mx3.usuhs.mil Y1 - 1998/06// PY - 1998 DA - Jun 1998 SP - 91 EP - 102 VL - 8 IS - 2 SN - 1053-0487, 1053-0487 KW - Americans With Disabilities Act KW - musculoskeletal system KW - occupational health KW - work re-entry KW - Health & Safety Science Abstracts KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16437314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+Rehabilitation&rft.atitle=Americans+with+Disabilities+Act+litigation+and+musculoskeletal-related+impairments%3A+Implications+for+work+re-entry&rft.au=Huang%2C+G+D%3BFeuerstein%2C+M&rft.aulast=Huang&rft.aufirst=G&rft.date=1998-06-01&rft.volume=8&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Rehabilitation&rft.issn=10530487&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Lipopolysaccharide and its analog antagonists display differential serum factor dependencies for induction of cytokine genes in murine macrophages AN - 16418062; 4322866 AB - Monocytes/macrophages play a central role in mediating the effects of lipopolysaccharide (LPS) derived from gram-negative bacteria by the production of proinflammatory mediators. Recently, it was shown that the expression of cytokine genes for tumor necrosis factor alpha (TNF- alpha ), interleukin-1 beta (IL-1 beta ), and interferon-inducible protein-10 (IP-10) by murine macrophages in response to low concentrations of LPS is entirely CD14 dependent. In this report, we show that murine macrophages respond to low concentrations of LPS ( less than or equal to 2 ng/ml) in the complete absence of serum, leading to the induction of TNF- alpha and IL-1 beta genes. In contrast to the TNF- alpha and IL-1 beta genes, the IP-10 gene is poorly induced in the absence of serum. The addition of recombinant human soluble CD14 (rsCD14) had very little effect on the levels of serum-free, LPS-induced TNF- alpha , IL-1 beta , and IP-10 genes. In contrast, the addition of recombinant human LPS-binding protein (rLBP) had opposing effects on the LPS-induced TNF- alpha or IL-1 beta and IP-10 genes. rLBP inhibited LPS-induced TNF- alpha and IL-1 beta genes, while it reconstituted IP-10 gene expression to levels induced in the presence of serum. These results provide further evidence that the induction of TNF- alpha or IL-1 beta genes occurs via a pathway that is distinct from one that leads to the induction of the IP-10 gene and that the pathways diverge at the level of the initial interaction between LPS and cellular CD14. Additionally, the results presented here indicate that LPS structural analog antagonists Rhodobacter sphaeroides diphosphoryl lipid A and SDZ 880.431 are able to inhibit LPS-induced TNF- alpha and IL-1 beta in the absence of serum, while a synthetic analog of Rhodobacter capsulatus lipid A (B 975) requires both rsCD14 and rLBP to function as an inhibitor. JF - Infection and Immunity AU - Perera, P-Y AU - Qureshi, N AU - Christ, W J AU - Stuetz, P AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Sciences University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA, vogel@usuhsb.usuhs.mil Y1 - 1998/06// PY - 1998 DA - Jun 1998 SP - 2562 EP - 2569 VL - 66 IS - 6 SN - 0019-9567, 0019-9567 KW - lipopolysaccharides KW - mice KW - serum KW - serum factor KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - J 02833:Immune response and immune mechanisms KW - F 06764:Function UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16418062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Lipopolysaccharide+and+its+analog+antagonists+display+differential+serum+factor+dependencies+for+induction+of+cytokine+genes+in+murine+macrophages&rft.au=Perera%2C+P-Y%3BQureshi%2C+N%3BChrist%2C+W+J%3BStuetz%2C+P%3BVogel%2C+S+N&rft.aulast=Perera&rft.aufirst=P-Y&rft.date=1998-06-01&rft.volume=66&rft.issue=6&rft.spage=2562&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Function-structure studies and identification of three enzyme domains involved in the catalytic activity in rat hepatic squalene synthase. AN - 79865758; 9575210 AB - Rat hepatic squalene synthase (RSS, EC 2.5.1.21) contains three conserved sections, A, B, and C, that were proposed to be involved in catalysis (McKenzie, T. L., Jiang, G., Straubhaar, J. R., Conrad, D., and Shechter, I. (1992) J. Biol. Chem. 267, 21368-21374). Here we use the high expression vector pTrxRSS and site-directed mutagenesis to determine the specific residues in these sections that are essential for the two reactions catalyzed by RSS. Section C mutants F288Y, F288L, F286Y, F286W, F286L, Q293N, and Q283E accumulate presqualene diphosphate (PSPP) from trans-farnesyl diphosphate (FPP) with reduced production of squalene. F288L, which retains approximately 50% first step activity, displays only residual activity (0.2%) in the production of squalene from either FPP or PSPP. Substitution of either Phe288 or Phe286 with charged residues completely abolishes the enzyme activity. Thus, F288W, F288D, F288R, F286D, and F286R cannot produce squalene from either FPP or PSPP. All single residue mutants in Section A, except Tyr171, retain most of the RSS activity, with no detectable accumulation of PSPP in an assay mixture complete with NADPH. Y171F, Y171S, and Y171W are all inactive. Section B, which binds the diphosphate moieties of the allylic diphosphate subtrates, contains four negatively charged residues: Glu222, Glu226, Asp219, and Asp223. The two Glu residues can be replaced with neutral or with positively charged residues without signficantly affecting enzyme activity. However, replacement of either Asp residues with Asn eliminates all but a residual level of activity, and substitution with Glu abolishes all activity. These results indicate that 1) Section C, in particular Phe288, may be involved in the second step of catalysis, 2) Tyr171 of Section A is essential for catalysis, most likely for the first reaction, 3) the two Asp residues in Section B are essential for the activity and most likely bind the substrate via magnesium salt bridges. Based on these results, a mechanism for the first reaction is proposed. JF - The Journal of biological chemistry AU - Gu, P AU - Ishii, Y AU - Spencer, T A AU - Shechter, I AD - Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1998/05/15/ PY - 1998 DA - 1998 May 15 SP - 12515 EP - 12525 VL - 273 IS - 20 SN - 0021-9258, 0021-9258 KW - Recombinant Proteins KW - 0 KW - Farnesyl-Diphosphate Farnesyltransferase KW - EC 2.5.1.21 KW - Index Medicus KW - Animals KW - Sequence Homology, Nucleic Acid KW - Humans KW - Amino Acid Sequence KW - Recombinant Proteins -- genetics KW - Structure-Activity Relationship KW - Mutagenesis, Site-Directed KW - Rats KW - Recombinant Proteins -- metabolism KW - Genetic Vectors KW - Molecular Sequence Data KW - Recombinant Proteins -- chemistry KW - Catalysis KW - Liver -- enzymology KW - Farnesyl-Diphosphate Farnesyltransferase -- genetics KW - Farnesyl-Diphosphate Farnesyltransferase -- metabolism KW - Farnesyl-Diphosphate Farnesyltransferase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79865758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Function-structure+studies+and+identification+of+three+enzyme+domains+involved+in+the+catalytic+activity+in+rat+hepatic+squalene+synthase.&rft.au=Gu%2C+P%3BIshii%2C+Y%3BSpencer%2C+T+A%3BShechter%2C+I&rft.aulast=Gu&rft.aufirst=P&rft.date=1998-05-15&rft.volume=273&rft.issue=20&rft.spage=12515&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-06-12 N1 - Date created - 1998-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Biol Chem 1998 Jul 3;273(27):17296 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential transcriptional regulation of the human squalene synthase gene by sterol regulatory element-binding proteins (SREBP) 1a and 2 and involvement of 5' DNA sequence elements in the regulation. AN - 79865336; 9575211 AB - Transcription of the human squalene synthase (HSS) gene is regulated by variations in the level of cellular cholesterol. Three regulatory elements in the HSS promoter region are known to be involved in the regulation: 1) a modified sterol regulatory element (SRE) 1 (HSS-SRE-1), 2) an inverted SRE-3 (Inv-SRE-3), 3) an inverted Y box (Inv-Y-Box). We report here the regulatory role of distinct cis-elements in the HSS promoter by using mutants of an HSS-luciferase promoter reporter. The activity of a wild-type promoter reporter transiently transfected into HepG-2 cells is increased by sterol depletion of the cells or by coexpression of mature forms of the SRE-binding proteins (SREBP) 1a and SREBP-2. Differential activation by SREBP-1a and SREBP-2 of the reporter gene mutated at various regions of the promoter is observed. Mutation of either the HSS-SRE-1 or the Inv-SRE-3 sequence diminished the activation by SREBP-1a and by sterol depletion but did not affect the activation by SREBP-2. Simultaneous mutations of both of these sequences almost completely abolished activation of the promoter by SREBP-1a or by sterol depletion, but activation by SREBP-2 was retained at 70%. Mutation of the Inv-Y-Box sequence element decreased the activity of the promoter by 50% or more, and if mutated together with both SREs, the activation was almost completely abolished. Mutation of any single GC box of the two located at -40 to -57 did not affect activity, whereas simultaneous mutation of the two decreased activation by SREBP-2 by 60%, by lipid depletion by 20%, and had no effect on the activation by SREBP-1a. A Y box motif at -159 to -166 and an SRE-like sequence element (SRE-1(8/10)) at position -101 to -108 are also involved in the sterol regulation. These results indicate that the complex sterol-mediated transcriptional regulation of the HSS gene is due to the presence of multiple copies of diverse cis elements in the HSS promoter. The differential activation of the HSS promoter may point to specific role of the SREBPs in cholesterogenesis. JF - The Journal of biological chemistry AU - Guan, G AU - Dai, P AU - Shechter, I AD - Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1998/05/15/ PY - 1998 DA - 1998 May 15 SP - 12526 EP - 12535 VL - 273 IS - 20 SN - 0021-9258, 0021-9258 KW - CCAAT-Enhancer-Binding Proteins KW - 0 KW - DNA-Binding Proteins KW - Nuclear Proteins KW - SREBF1 protein, human KW - SREBF2 protein, human KW - Sterol Regulatory Element Binding Protein 1 KW - Sterol Regulatory Element Binding Protein 2 KW - Transcription Factors KW - Farnesyl-Diphosphate Farnesyltransferase KW - EC 2.5.1.21 KW - Index Medicus KW - Promoter Regions, Genetic KW - Tumor Cells, Cultured KW - Humans KW - Mutagenesis KW - Gene Expression Regulation, Enzymologic KW - Farnesyl-Diphosphate Farnesyltransferase -- genetics KW - Transcription Factors -- metabolism KW - Transcription, Genetic KW - Nuclear Proteins -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79865336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Differential+transcriptional+regulation+of+the+human+squalene+synthase+gene+by+sterol+regulatory+element-binding+proteins+%28SREBP%29+1a+and+2+and+involvement+of+5%27+DNA+sequence+elements+in+the+regulation.&rft.au=Guan%2C+G%3BDai%2C+P%3BShechter%2C+I&rft.aulast=Guan&rft.aufirst=G&rft.date=1998-05-15&rft.volume=273&rft.issue=20&rft.spage=12526&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-06-12 N1 - Date created - 1998-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The encephalopathy associated with murine acquired immunodeficiency syndrome. AN - 79943817; 9629308 AB - Mice infected with the LP-BM5 murine leukemia virus (MuLV) develop an immune deficiency syndrome together with an encephalopathy characterized by impairments in spatial learning and memory. These cognitive deficits are evident before the appearance of neuron loss and lymphoid cell invasion of the brain. Nonetheless, a prominent gliosis and a variety of neurochemical changes precede the development of cognitive deficits. The neurochemical abnormalities include significant decreases in striatal Met-enkephalin and substance P (but not somatostatin), increases in concentrations of quinolinic acid and platelet-activating factor, and alterations in brain fyn kinase. At this stage of the infection, some of these neurochemical changes can be reversed by glutamate receptor antagonists, cytokine inhibitors, and anti-retroviral agents. In later stages of the infection, however, the infected mice develop irreversible neuronal loss, invasion of hematopoietic cells, and increased viral burden in the CNS. In addition, motor-neuron dysfunction (hindlimb paralysis, weakness, and ataxia) and seizures are sometimes observed during the late stages of infection. Thus, the LP-BM5 MuLV-infected mouse is a useful model for studying the chronology of neurodegenerative changes, ranging from reversible neuron dysfunction to irreversible neuron loss, that are associated with retrovirus-induced immunodeficiency. JF - Annals of the New York Academy of Sciences AU - Sei, Y AU - Kustova, Y AU - Li, Y AU - Morse, H C AU - Skolnick, P AU - Basile, A S AD - Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20892, USA. ysei@mx3.usuhs.mil Y1 - 1998/05/01/ PY - 1998 DA - 1998 May 01 SP - 822 EP - 834 VL - 840 SN - 0077-8923, 0077-8923 KW - Neurotoxins KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Animals KW - Neurotoxins -- metabolism KW - Maze Learning -- physiology KW - Brain -- pathology KW - Brain -- metabolism KW - Brain Diseases -- virology KW - Murine Acquired Immunodeficiency Syndrome -- complications KW - Brain Diseases -- psychology KW - Murine Acquired Immunodeficiency Syndrome -- physiopathology KW - Brain Diseases -- physiopathology KW - Murine Acquired Immunodeficiency Syndrome -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79943817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=The+encephalopathy+associated+with+murine+acquired+immunodeficiency+syndrome.&rft.au=Sei%2C+Y%3BKustova%2C+Y%3BLi%2C+Y%3BMorse%2C+H+C%3BSkolnick%2C+P%3BBasile%2C+A+S&rft.aulast=Sei&rft.aufirst=Y&rft.date=1998-05-01&rft.volume=840&rft.issue=&rft.spage=822&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-09 N1 - Date created - 1998-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gonorrhea among Drug Users: An Alaskan versus a National Sample AN - 61443014; 199902067 AB - Interview data are used to investigate the replicability of gender-specific risk profiles for gonorrhea based on an Anchorage, AK, sample, as compared to a US national sample, of drug users (N = 1,049 & 17,619, respectively) at risk for human immunodeficiency virus (HIV) infection. Subjects comprised cocaine smokers & injection drug users not in drug treatment. A history of gonorrhea infection was self-reported & coded as ever or never. The Anchorage & national risk profile for men included the following factors: (1) history of intranasal or parental cocaine use, (2) being black vs nonblack, (3) being older, (4) income from illegal activity, & (5) history of amphetamine use. The Anchorage & national risk profiles for women included the following factors: (A) trading sex for money, (B) being Native American vs non-Native American, & (C) trading sex for drugs. The Anchorage model for women included perceived homelessness as a factor, but it was not retained in the national model. The extent of the replicability of these models illustrates the generalizability of Alaskan findings to other US drug-using populations. Implications for disease prevention are also discussed. 5 Tables, 40 References. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Paschane, David M AU - Fisher, Dennis G AU - Cagle, Henry H AU - Fenaughty, Andrea M AD - NDU Project U Alaska, Anchorage tel: 907-786-1801 Y1 - 1998/05// PY - 1998 DA - May 1998 SP - 285 EP - 297 VL - 24 IS - 2 SN - 0095-2990, 0095-2990 KW - Sexual Behavior KW - Risk KW - Venereal Diseases KW - Sex Differences KW - United States of America KW - Alaska KW - Drug Abuse KW - article KW - 6129: social welfare KW - 6126: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61443014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Gonorrhea+among+Drug+Users%3A+An+Alaskan+versus+a+National+Sample&rft.au=Paschane%2C+David+M%3BFisher%2C+Dennis+G%3BCagle%2C+Henry+H%3BFenaughty%2C+Andrea+M&rft.aulast=Paschane&rft.aufirst=David&rft.date=1998-05-01&rft.volume=24&rft.issue=2&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Venereal Diseases; Drug Abuse; Risk; Alaska; United States of America; Sexual Behavior; Sex Differences ER - TY - JOUR T1 - Tracking the evolution of a hydrothermal event plume with a RAFOS neutrally buoyant drifter AN - 52606696; 1998-033806 JF - Science AU - Lupton, John E AU - Baker, Edward T AU - Garfield, Newell AU - Massoth, Gary J AU - Feely, Richard A AU - Cowen, James P AU - Greene, Ronald R AU - Rago, Thomas A Y1 - 1998/05// PY - 1998 DA - May 1998 SP - 1052 EP - 1055 PB - American Association for the Advancement of Science, Washington, DC VL - 280 IS - 5366 SN - 0036-8075, 0036-8075 KW - East Pacific KW - concentration KW - sea water KW - Northeast Pacific KW - isotopes KW - RAFOS KW - hydrothermal vents KW - anomalies KW - He-3 KW - hydrochemistry KW - stable isotopes KW - Gorda Rise KW - temperature KW - North Pacific KW - Juan de Fuca Ridge KW - circulation KW - noble gases KW - Pacific Ocean KW - helium KW - ocean floors KW - chemical composition KW - instruments KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52606696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=Tracking+the+evolution+of+a+hydrothermal+event+plume+with+a+RAFOS+neutrally+buoyant+drifter&rft.au=Lupton%2C+John+E%3BBaker%2C+Edward+T%3BGarfield%2C+Newell%3BMassoth%2C+Gary+J%3BFeely%2C+Richard+A%3BCowen%2C+James+P%3BGreene%2C+Ronald+R%3BRago%2C+Thomas+A&rft.aulast=Lupton&rft.aufirst=John&rft.date=1998-05-01&rft.volume=280&rft.issue=5366&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/ L2 - http://www.sciencemag.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 38 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch maps N1 - Last updated - 2012-06-07 N1 - CODEN - SCIEAS N1 - SubjectsTermNotLitGenreText - anomalies; chemical composition; circulation; concentration; East Pacific; Gorda Rise; He-3; helium; hydrochemistry; hydrothermal vents; instruments; isotopes; Juan de Fuca Ridge; noble gases; North Pacific; Northeast Pacific; ocean floors; Pacific Ocean; RAFOS; sea water; stable isotopes; temperature ER - TY - JOUR T1 - Differential early interactions between Salmonella enterica serovar typhi and two other pathogenic Salmonella serovars with intestinal epithelial cells AN - 16482485; 4307621 AB - Salmonella enterica serovar typhi (hereafter referred to as S. typhi) is a host-restricted pathogen that adheres to and invades the distal ileum and subsequently disseminates to cause typhoid fever in humans. However, S. typhi appears to be avirulent in small animals. In contrast, other pathogenic salmonellae, such as S. enterica serovars typhimurium and dublin (S. typhimurium and S. dublin, respectively), typically cause localized gastroenteritis in humans but have been used as models for typhoid fever because these organisms cause a disease in susceptible rodents that resembles human typhoid. In vivo, S. typhi has been demonstrated to attach to and invade murine M cells but is rapidly cleared from the Peyer's patches without destruction of the M cells. In contrast, invasion of M cells by S. typhimurium is accompanied by destruction of these M cells and subsequently sloughing of the epithelium. These data have furthered our view that the early steps in the pathogenesis of typhoidal and nontyphoidal Salmonella serovars are distinct. To extend this concept, we have utilized an in vitro model to evaluate three parameters of initial host-pathogen interactions: adherence of three Salmonella serovars to human and murine small intestinal epithelial cell (IEC) lines, the capacity of these salmonellae to invade IECs, and the ability of the bacteria to induce interleukin-6 (IL-6) in these cell lines as a measure of host cell activation and the host acute-phase response. The results demonstrate that S. typhi adheres to and invades human small IECs better than either S. typhimurium or S. dublin. Interestingly, invA and invE null mutants of S. typhi are able neither to adhere to nor to invade IECs, unlike S. typhimurium invA and invE mutants, which adhere to but cannot invade IECs. S. typhi also induces significantly greater quantities of IL-6 in human small IEC lines than either of the other two Salmonella serovars. These findings suggest that differential host cytokine responses to bacterial pathogens may play an important role in the pathological sequelae that follow infection. Importantly, S. typhimurium did not induce IL-6 in murine IECs. Since S. typhimurium infection in mice is often used as a model of typhoid fever, these findings suggest that, at least in this case, the mouse model does not reflect the human disease. Taken together, our studies indicate that (i) marked differences occur in the initial steps of S. typhi, S. typhimurium, and S. dublin pathogenesis, and (ii) conclusions about S. typhi pathogenesis that have been drawn from the mouse model of typhoid fever should be interpreted conservatively. JF - Infection and Immunity AU - Weinstein, D L AU - O'Neill, B L AU - Hone, D M AU - Metcalf, E S AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814-5799, USA, metcalf@usuhsb.usuhs.mil Y1 - 1998/05// PY - 1998 DA - May 1998 SP - 2310 EP - 2318 VL - 66 IS - 5 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16482485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Differential+early+interactions+between+Salmonella+enterica+serovar+typhi+and+two+other+pathogenic+Salmonella+serovars+with+intestinal+epithelial+cells&rft.au=Weinstein%2C+D+L%3BO%27Neill%2C+B+L%3BHone%2C+D+M%3BMetcalf%2C+E+S&rft.aulast=Weinstein&rft.aufirst=D&rft.date=1998-05-01&rft.volume=66&rft.issue=5&rft.spage=2310&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - NFAT interactions with the vasoactive intestinal peptide cytokine response element. AN - 79809748; 9556032 AB - The vasoactive intestinal peptide cytokine response element (VIP CyRE) is responsible for mediating the transcriptional induction of the VIP gene to the neuropoietic cytokines leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF). In investigating the sequence and function of the CyRE, we found a region of DNA with homology to the distal NFAT site in the IL-2 promoter. In this paper we characterize this sequence and show that the VIP NFAT site recognizes T cell NFAT with similar affinity to the previously characterized IL-2 NFAT site. However, despite its location in the middle of the CyRE, we find no CNTF/LIF induced binding to it. Instead we show that in NBFL neuroblastoma cells, the calcium ionophore A23187 induces a protein to bind to the VIP NFAT site. This A23187-mediated induction of nuclear protein binding to an NFAT oligonucleotide is dependent on extracellular calcium but not dependent on de novo protein synthesis. Thus, this protein has the characteristics of an NFAT-like protein and is recognized by an NFAT3-specific antiserum suggesting that it is indeed an NFAT protein. The location of the NFAT site in the VIP CyRE suggests that this may be one mechanism through which different signaling pathways engage in cross talk to alter VIP gene transcription. JF - Journal of neuroscience research AU - Symes, A AU - Gearan, T AU - Fink, J S AD - Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, USA. Symes@bob.usuf2.usuhs.mil Y1 - 1998/04/01/ PY - 1998 DA - 1998 Apr 01 SP - 93 EP - 104 VL - 52 IS - 1 SN - 0360-4012, 0360-4012 KW - Ciliary Neurotrophic Factor KW - 0 KW - Cytokines KW - DNA Primers KW - DNA-Binding Proteins KW - Growth Inhibitors KW - Interleukin-6 KW - LIF protein, human KW - Leukemia Inhibitory Factor KW - Lymphokines KW - NFATC Transcription Factors KW - Nerve Growth Factors KW - Nerve Tissue Proteins KW - Nuclear Proteins KW - Recombinant Proteins KW - Transcription Factors KW - Vasoactive Intestinal Peptide KW - 37221-79-7 KW - Calcimycin KW - 37H9VM9WZL KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Recombinant Proteins -- pharmacology KW - Recombinant Proteins -- biosynthesis KW - Nerve Growth Factors -- pharmacology KW - DNA -- metabolism KW - Humans KW - Calcimycin -- pharmacology KW - Neuroblastoma KW - Binding Sites KW - Mutagenesis, Site-Directed KW - Regulatory Sequences, Nucleic Acid KW - Base Sequence KW - Tumor Cells, Cultured KW - Transfection KW - DNA -- chemistry KW - Signal Transduction KW - Vasoactive Intestinal Peptide -- biosynthesis KW - Transcription, Genetic -- drug effects KW - Cytokines -- pharmacology KW - Transcription Factors -- metabolism KW - Lymphokines -- pharmacology KW - Growth Inhibitors -- pharmacology KW - Vasoactive Intestinal Peptide -- genetics KW - Nerve Tissue Proteins -- pharmacology KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79809748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=NFAT+interactions+with+the+vasoactive+intestinal+peptide+cytokine+response+element.&rft.au=Symes%2C+A%3BGearan%2C+T%3BFink%2C+J+S&rft.aulast=Symes&rft.aufirst=A&rft.date=1998-04-01&rft.volume=52&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-05-29 N1 - Date created - 1998-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Describing sorption mass transfer by diffusion into a composite particle AN - 52419569; 2000-000843 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Shepherd, David AU - Heyse, Edward C AU - McGowin, Audrey AU - Coulliette, David L AU - Anonymous Y1 - 1998/04// PY - 1998 DA - April 1998 PB - American Chemical Society, Washington, DC VL - 215 IS - 1-2 SN - 0065-7727, 0065-7727 KW - soils KW - sorption KW - experimental studies KW - diffusion KW - pollutants KW - pollution KW - bioavailability KW - models KW - organic compounds KW - transport KW - mass transfer KW - geochemistry KW - hydrophobic materials KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52419569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Describing+sorption+mass+transfer+by+diffusion+into+a+composite+particle&rft.au=Shepherd%2C+David%3BHeyse%2C+Edward+C%3BMcGowin%2C+Audrey%3BCoulliette%2C+David+L%3BAnonymous&rft.aulast=Shepherd&rft.aufirst=David&rft.date=1998-04-01&rft.volume=215&rft.issue=1-2&rft.spage=ENVR+045&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 215th American Chemical Society national meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - bioavailability; diffusion; experimental studies; geochemistry; hydrophobic materials; mass transfer; models; organic compounds; pollutants; pollution; soils; sorption; transport ER - TY - JOUR T1 - A pharmacokinetic study of occupational and environmental benzene exposure with regard to gender AN - 16442280; 4341734 AB - Using physiologically-based pharmacokinetic (PBPK) modeling, occupational, personal, and environmental benzene exposure scenarios are simulated for adult men and women. This research identifies differences in internal exposure due to physiological and biochemical gender differences. Physiological and chemical-specific model parameters were obtained from other studies reported in the literature and medical texts for the subjects of interest. Women were found to have a higher blood/air partition coefficient and maximum velocity of metabolism for benzene than men (the two most sensitive parameters affecting gender-specific differences). Additionally, women generally have a higher body fat percentage than men. These factors influence the internal exposure incurred by the subjects and should be considered when conducting a risk assessment. Results demonstrated that physicochemical gender differences result in women metabolizing 23-26% more benzene than men when subject to the same exposure scenario even though benzene blood concentration levels are generally higher in men. These results suggest that women may be at significantly higher risk for certain effects of benzene exposure. Thus, exposure standards based on data from male subjects may not be protective for the female population. JF - Risk Analysis AU - Brown, E A AU - Shelley, M L AU - Fisher, J W AD - Air Force Institute of Technology, WPAFB, OH, USA Y1 - 1998/04// PY - 1998 DA - Apr 1998 SP - 205 EP - 213 VL - 18 IS - 2 SN - 0272-4332, 0272-4332 KW - benzene KW - man KW - pharmacokinetics KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - R2 23080:Industrial and labor KW - X 24153:Metabolism KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16442280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=A+pharmacokinetic+study+of+occupational+and+environmental+benzene+exposure+with+regard+to+gender&rft.au=Brown%2C+E+A%3BShelley%2C+M+L%3BFisher%2C+J+W&rft.aulast=Brown&rft.aufirst=E&rft.date=1998-04-01&rft.volume=18&rft.issue=2&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - 'Black holes' and bacterial pathogenicity: A large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli AN - 16343982; 4266944 AB - Plasmids, bacteriophages, and pathogenicity islands are genomic additions that contribute to the evolution of bacterial pathogens. For example, Shigella spp., the causative agents of bacillary dysentery, differ from the closely related commensal Escherichia super( ) coli in the presence of a plasmid in Shigella that encodes virulence functions. However, pathogenic bacteria also may lack properties that are characteristic of nonpathogens. Lysine decarboxylase (LDC) activity is present in ~90% of E. coli strains but is uniformly absent in Shigella strains. When the gene for LDC, cadA, was introduced into Shigella flexneri 2a, virulence became attenuated, and enterotoxin activity was inhibited greatly. The enterotoxin inhibitor was identified as cadaverine, a product of the reaction catalyzed by LDC. Comparison of the S. flexneri 2a and laboratory E. coli K-12 genomes in the region of cadA revealed a large deletion in Shigella. Representative strains of Shigella spp. and enteroinvasive E. coli displayed similar deletions of cadA. Our results suggest that, as Shigella spp. evolved from E. coli to become pathogens, they not only acquired virulence genes on a plasmid but also shed genes via deletions. The formation of these 'black holes,' deletions of genes that are detrimental to a pathogenic lifestyle, provides an evolutionary pathway that enables a pathogen to enhance virulence. Furthermore, the demonstration that cadaverine can inhibit enterotoxin activity may lead to more general models about toxin activity or entry into cells and suggests an avenue for antitoxin therapy. Thus, understanding the role of black holes in pathogen evolution may yield clues to new treatments of infectious diseases. JF - Proceedings of the National Academy of Sciences, USA AU - Maurelli, A AU - Fernandez, R AU - Bloch, C AU - Rode, C AU - Fasano, A AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, MD 20814-4799, maurelli@usuhsb.usuhs.mil Y1 - 1998/03/31/ PY - 1998 DA - 1998 Mar 31 SP - 3943 EP - 3948 VL - 95 IS - 7 SN - 0027-8424, 0027-8424 KW - black holes KW - cadA gene KW - cadaverine KW - therapy KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16343982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=%27Black+holes%27+and+bacterial+pathogenicity%3A+A+large+genomic+deletion+that+enhances+the+virulence+of+Shigella+spp.+and+enteroinvasive+Escherichia+coli&rft.au=Maurelli%2C+A%3BFernandez%2C+R%3BBloch%2C+C%3BRode%2C+C%3BFasano%2C+A&rft.aulast=Maurelli&rft.aufirst=A&rft.date=1998-03-31&rft.volume=95&rft.issue=7&rft.spage=3943&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - BUCK ISLAND REEF NATIONAL MONUMENT HAWKSBILL NESTING BEACH STUDY-COULD CONSERVATION BE WORKING? AN - 21080933; 11287647 AB - Sea turtle conservation at Buck Island Reef National Monument (BUIS), which is administered by the National Park Service (NPS), encompasses the protection and management of the nesting habitat, adult female sea turtles nesting at Buck Island, their eggs, and resulting hatchlings. Two federal mandates have guided the conservation of sea turtles at Buck Island. The Endangered Species Act in 1973, which stated that federal agencies shall seek to conserve endangered species (USFWS 1989), and the National Marine Fisheries Service/US Fish and Wildlife Service Hawksbill Recovery Plan which stated the need for long-term protection of important tinue providing a safe area for sea turtles to nest and from which hatchlings can leave the beaches to join the rest of the Caribbean population of hawksbill turtles to maintain the diversity necessary for the species to survive. JF - NOAA Technical Memorandum NMFS SEFSC AU - Hillis-Starr, Z AU - Phillips, B AD - National Park Service, Resource Management, Buck Island Reef National Monument, Danish Customs House, Kings Wharf #100, Christiansted, Virgin Islands 00820-4611, USA, CHRI.Interpretation@nps.gov Y1 - 1998/03/07/ PY - 1998 DA - 1998 Mar 07 SP - 11 IS - 436 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts KW - Marine fisheries KW - Marine KW - Juveniles KW - Fish eggs KW - Aquatic reptiles KW - Rare species KW - ASW, Caribbean Sea KW - ASW, Lesser Antilles, US Virgin Is., Buck I. KW - Nesting KW - Species diversity KW - Governments KW - Reproductive behaviour KW - Q5 08523:Conservation, wildlife management and recreation KW - O 4090:Conservation and Environmental Protection KW - Q1 08423:Behaviour UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21080933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NOAA+Technical+Memorandum+NMFS+SEFSC&rft.atitle=BUCK+ISLAND+REEF+NATIONAL+MONUMENT+HAWKSBILL+NESTING+BEACH+STUDY-COULD+CONSERVATION+BE+WORKING%3F&rft.au=Hillis-Starr%2C+Z%3BPhillips%2C+B&rft.aulast=Hillis-Starr&rft.aufirst=Z&rft.date=1998-03-07&rft.volume=&rft.issue=436&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=NOAA+Technical+Memorandum+NMFS+SEFSC&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Marine fisheries; Juveniles; Fish eggs; Nesting; Species diversity; Aquatic reptiles; Governments; Rare species; Reproductive behaviour; ASW, Caribbean Sea; ASW, Lesser Antilles, US Virgin Is., Buck I.; Marine ER - TY - JOUR T1 - Role of mitochondrial Ca2+ regulation in neuronal and glial cell signalling. AN - 79892844; 9600625 AB - It is becoming increasingly clear that mitochondrial Ca2+ uptake from and release into the cytosol has important consequences for neuronal and glial activity. Ca2+ regulates mitochondrial metabolism, and mitochondrial Ca2+ uptake and release modulate physiological and pathophysiological cytosolic responses. In glial cells, inositol 1,4,5-trisphosphate-dependent Ca2+ responses are faithfully translated into elevations in mitochondrial Ca2+ levels, which modifies cytosolic Ca2+ wave propagation and may activate mitochondrial enzymes. The location of mitochondria within neurones may partially determine their role in Ca2+ signalling. Neuronal death due to NMDA-evoked Ca2+ entry can be delayed by an inhibitor of the mitochondrial permeability transition pore, and mitochondrial dysfunction is being increasingly implicated in a number of neurodegenerative conditions. These findings are illustrative of an emerging realization by neuroscientists of the importance of mitochondrial Ca2+ regulation as a modulator of cellular energetics, endoplasmic reticulum Ca2+ release and neurotoxicity. JF - Brain research. Brain research reviews AU - Simpson, P B AU - Russell, J T AD - Department of Anatomy and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 1998/03// PY - 1998 DA - March 1998 SP - 72 EP - 81 VL - 26 IS - 1 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Humans KW - Neuroglia -- metabolism KW - Signal Transduction -- physiology KW - Neurons -- metabolism KW - Neuroglia -- ultrastructure KW - Calcium -- physiology KW - Mitochondria -- metabolism KW - Neurons -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79892844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research.+Brain+research+reviews&rft.atitle=Role+of+mitochondrial+Ca2%2B+regulation+in+neuronal+and+glial+cell+signalling.&rft.au=Simpson%2C+P+B%3BRussell%2C+J+T&rft.aulast=Simpson&rft.aufirst=P&rft.date=1998-03-01&rft.volume=26&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Brain+research.+Brain+research+reviews&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-07 N1 - Date created - 1998-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutational analysis of the virus and monoclonal antibody binding sites in MHVR, the cellular receptor of the murine coronavirus mouse hepatitis virus strain A59. AN - 79697624; 9499047 AB - The primary cellular receptor for mouse hepatitis virus (MHV), a murine coronavirus, is MHVR (also referred to as Bgp1a or C-CAM), a transmembrane glycoprotein with four immunoglobulin-like domains in the murine biliary glycoprotein (Bgp) subfamily of the carcinoembryonic antigen (CEA) family. Other murine glycoproteins in the Bgp subfamily, including Bgp1b and Bgp2, also can serve as MHV receptors when transfected into MHV-resistant cells. Previous studies have shown that the 108-amino-acid N-terminal domain of MHVR is essential for virus receptor activity and is the binding site for monoclonal antibody (MAb) CC1, an antireceptor MAb that blocks MHV infection in vivo and in vitro. To further elucidate the regions of MHVR required for virus receptor activity and MAb CC1 binding, we constructed chimeras between MHVR and other members of the CEA family and tested them for MHV strain A59 (MHV-A59) receptor activity and MAb CC1 binding activity. In addition, we used site-directed mutagenesis to introduce selected amino acid changes into the N-terminal domains of MHVR and these chimeras and tested the abilities of these mutant glycoproteins to bind MAb CC1 and to function as MHV receptors. Several recombinant glycoproteins exhibited virus receptor activity but did not bind MAb CC1, indicating that the virus and MAb binding sites on the N-terminal domain of MHVR are not identical. Analysis of the recombinant glycoproteins showed that a short region of MHVR, between amino acids 34 and 52, is critical for MHV-A59 receptor activity. Additional regions of the N-terminal variable domain and the constant domains, however, greatly affected receptor activity. Thus, the molecular context in which the amino acids critical for MHV-A59 receptor activity are found profoundly influences the virus receptor activity of the glycoprotein. JF - Journal of virology AU - Wessner, D R AU - Shick, P C AU - Lu, J H AU - Cardellichio, C B AU - Gagneten, S E AU - Beauchemin, N AU - Holmes, K V AU - Dveksler, G S AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1998/03// PY - 1998 DA - March 1998 SP - 1941 EP - 1948 VL - 72 IS - 3 SN - 0022-538X, 0022-538X KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - CD66 antigens KW - Carcinoembryonic Antigen KW - Cell Adhesion Molecules KW - Glycoproteins KW - Receptors, Virus KW - Index Medicus KW - Animals KW - Antibodies, Monoclonal -- metabolism KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - Cell Line KW - Protein Conformation KW - Cricetinae KW - Binding Sites KW - Glycoproteins -- immunology KW - Carcinoembryonic Antigen -- metabolism KW - Murine hepatitis virus -- metabolism KW - Glycoproteins -- metabolism KW - Carcinoembryonic Antigen -- immunology KW - Receptors, Virus -- immunology KW - Receptors, Virus -- metabolism KW - Receptors, Virus -- genetics KW - Murine hepatitis virus -- isolation & purification KW - Glycoproteins -- genetics KW - Carcinoembryonic Antigen -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79697624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Mutational+analysis+of+the+virus+and+monoclonal+antibody+binding+sites+in+MHVR%2C+the+cellular+receptor+of+the+murine+coronavirus+mouse+hepatitis+virus+strain+A59.&rft.au=Wessner%2C+D+R%3BShick%2C+P+C%3BLu%2C+J+H%3BCardellichio%2C+C+B%3BGagneten%2C+S+E%3BBeauchemin%2C+N%3BHolmes%2C+K+V%3BDveksler%2C+G+S&rft.aulast=Wessner&rft.aufirst=D&rft.date=1998-03-01&rft.volume=72&rft.issue=3&rft.spage=1941&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-12 N1 - Date created - 1998-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1716-20 [8383324] Virology. 1997 Mar 17;229(2):336-48 [9126247] J Virol. 1994 Jul;68(7):4525-37 [8207827] Virology. 1994 Sep;203(2):344-56 [7914388] J Virol. 1995 Jan;69(1):543-6 [7983753] Eur J Biochem. 1995 Apr 15;229(2):455-64 [7744068] Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12095-9 [8618851] J Virol. 1996 Apr;70(4):2632-6 [8642698] J Virol. 1996 Jun;70(6):4142-5 [8648757] J Gen Virol. 1996 Aug;77 ( Pt 8):1683-92 [8760415] J Biol Chem. 1996 Dec 20;271(51):33095-104 [8955157] J Virol. 1997 Feb;71(2):1688-91 [8995701] J Immunol. 1975 Jan;114(1 Pt 1):221-5 [163277] Proc Soc Exp Biol Med. 1976 Sep;152(4):499-502 [135262] Arch Virol. 1981;70(1):69-73 [6277284] Curr Top Microbiol Immunol. 1982;99:165-200 [6178564] J Immunol. 1982 Sep;129(3):1275-81 [6286761] J Immunol. 1984 Jul;133(1):428-32 [6327825] Arch Virol. 1984;81(1-2):103-12 [6331343] J Immunol. 1984 Sep;133(3):1609-13 [6146650] J Gen Virol. 1984 Jul;65 ( Pt 7):1165-71 [6205117] Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7 [6096719] Nature. 1984 Dec 20-1985 Jan 2;312(5996):767-8 [6083454] J Neuroimmunol. 1985 Apr;8(1):15-28 [2579095] J Immunol. 1985 Nov;135(5):3151-62 [2995487] J Virol. 1985 Dec;56(3):912-20 [2999444] J Immunol. 1986 Oct 1;137(7):2355-60 [3020124] Cell. 1986 Nov 7;47(3):333-48 [3094962] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8122-6 [3095828] Arch Virol. 1986;91(3-4):247-56 [3022679] J Virol. 1987 Jan;61(1):185-9 [3023696] Cell. 1988 Jul 1;54(1):65-72 [2454749] Nature. 1988 Jul 14;334(6178):159-62 [3260352] Nature. 1988 Sep 22;335(6188):363-6 [2843773] Cell. 1989 Mar 10;56(5):839-47 [2538243] Cell. 1989 Mar 10;56(5):849-53 [2538244] Cell. 1989 Mar 10;56(5):855-65 [2538245] Cell. 1989 May 5;57(3):469-81 [2541915] Proc Natl Acad Sci U S A. 1989 Jul;86(13):4907-11 [2544880] J Virol. 1990 Aug;64(8):3817-23 [2164599] Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5533-6 [1648219] Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):7993-7 [1716769] J Virol. 1991 Dec;65(12):6881-91 [1719235] J Exp Med. 1992 Aug 1;176(2):507-17 [1500858] J Virol. 1992 Oct;66(10):6194-9 [1326665] J Virol. 1992 Dec;66(12):6931-8 [1279194] J Virol. 1993 Jan;67(1):1-8 [8380065] J Biol Chem. 1993 Mar 25;268(9):6139-46 [8454589] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Small-scale morphology across the surf zone AN - 52605885; 1998-031637 AB - Small-scale (<5m horizontal length) nearshore morphologic height variations were measured by combining CRAB surveys with bed elevations acquired with a 1 MHz sonic altimeter mounted on the CRAB during the October Phase of the DUCK94 experiment. Bedform plan views were recorded simultaneously using a 500 kHz side-scan sonar mounted on the CRAB. Waves and currents were measured at the same time. Significant temporal and spatial variations in the small-scale morphology were measured in response to changing waves and currents during the 2 weeks examined. Three cases are examined in detail: (1) mild waves and weak longshore currents resulting in wave ripples throughout the study area; (2) storm waves with strong longshore currents resulting in lunate and straight-crested mega-ripples in the trough of the barred beach; and (3) narrow-band, normally incident waves with a strong rip current resulting in a planar bed except in the throat of the rip where mega-ripples were measured. Wavenumber spectra of the bed were generally broad, indicating newly formed ripples coexisted with residual ripples from the past to form complex, multi-scaled ripple patterns. JF - Marine Geology AU - Thornton, E B AU - Swayne, J L AU - Dingler, John R Y1 - 1998/03// PY - 1998 DA - March 1998 SP - 173 EP - 196 PB - Elsevier, Amsterdam VL - 145 IS - 3-4 SN - 0025-3227, 0025-3227 KW - currents KW - micromorphology KW - geophysical methods KW - longshore currents KW - nearshore environment KW - ripple marks KW - ocean currents KW - bedforms KW - bedding plane irregularities KW - acoustical methods KW - spatial variations KW - marine sediments KW - ocean waves KW - sediments KW - side-scanning methods KW - sedimentary structures KW - sonar methods KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52605885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Geology&rft.atitle=Small-scale+morphology+across+the+surf+zone&rft.au=Thornton%2C+E+B%3BSwayne%2C+J+L%3BDingler%2C+John+R&rft.aulast=Thornton&rft.aufirst=E&rft.date=1998-03-01&rft.volume=145&rft.issue=3-4&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Marine+Geology&rft.issn=00253227&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00253227 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 1998-01-01 N1 - Number of references - 16 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - MAGEA6 N1 - SubjectsTermNotLitGenreText - acoustical methods; bedding plane irregularities; bedforms; currents; geophysical methods; longshore currents; marine sediments; micromorphology; nearshore environment; ocean currents; ocean waves; ripple marks; sedimentary structures; sediments; side-scanning methods; sonar methods; spatial variations ER - TY - JOUR T1 - Resistogram typing of oral Candida albicans isolates from normal subjects in three successive trials AN - 17103360; 4402522 AB - Sixty-six oral strains of Candida albicans, which had been consecutively isolated from 22 normal, young females in three isolation trials at intervals of one to three weeks, were biotyped by their susceptibility to boric acid, cetrimide, silver nitrate, sodium periodate and sodium selenite. The 66 isolates were grouped into 13 resistogram types. An identical biotype strain was found three times and twice in seven and six each of the 22 subjects in the three isolation trials, respectively. In the remaining nine subjects, different strains were found at the three trials. These results suggested that certain strains tended to persist in the oral cavity of the normal subjects although changes in the biotype of oral C. albicans strains occurred to a certain extent. JF - Revista Iberoamericana De Micologia AU - Nakamura, K AU - Ito-Kuwa, S AU - Nakamura, Y AU - Aoki, S AU - Vidotto, V AU - Sinicco, A AD - General Research Institute, Nippon Dental University, 1-8 Hamaura-cho, Niigata 951-8580, Japan, aokis@ngt.ndu.ac.jp Y1 - 1998/03// PY - 1998 DA - Mar 1998 SP - 19 EP - 21 VL - 15 IS - 1 SN - 1130-1406, 1130-1406 KW - man KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Typing KW - Candida albicans KW - Oral cavity KW - K 03087:Fungi: human KW - A 01117:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17103360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Revista+Iberoamericana+De+Micologia&rft.atitle=Resistogram+typing+of+oral+Candida+albicans+isolates+from+normal+subjects+in+three+successive+trials&rft.au=Nakamura%2C+K%3BIto-Kuwa%2C+S%3BNakamura%2C+Y%3BAoki%2C+S%3BVidotto%2C+V%3BSinicco%2C+A&rft.aulast=Nakamura&rft.aufirst=K&rft.date=1998-03-01&rft.volume=15&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Revista+Iberoamericana+De+Micologia&rft.issn=11301406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Candida albicans; Oral cavity; Typing ER - TY - JOUR T1 - Cure of Helicobacter pylori infection by omeprazole-clarithromycin-based therapy in non-human primates. AN - 85418780; pmid-9497216 AB - Rhesus monkeys raised in colonies tend to become naturally infected by Helicobacter pylori early in life. Earlier attempts to cure H. pylori infection with a 10-day triple therapy (metronidazole, amoxicillin, and peptobismol) were only partially (60%) successful, probably because of preexisting metronidazole resistance. This study was carried out to determine the efficacy of an alternative clarithromycin-omeprazole-based therapy for curing H. pylori infection in Rhesus monkeys (Macaca mulatta), and to examine histologic and serologic correlates of curing. Five monkeys were endoscoped under ketamine anesthesia. Histology and culture of gastric biopsies and serologic tests demonstrated that they were H. pylori-positive. Two animals had not received prior anti-H. pylori treatment, while three other animals had failed triple therapy and carried metronidazole-resistant H. pylori strains. Quadruple therapy with omeprazole, clarithromycin, amoxicillin, and bismuth subsalicylate was given for 10 days to these five animals. All five animals were cured of the infection, and remained H. pylori-free, based on histology and culture at regular intervals for the 5 months posttherapy during which they were followed. Gastritis scores and anti-H. pylori IgG levels decreased in each animal during this period to levels characteristic of uninfected animals. These results indicate that an omeprazole-clarithromycin-based regimen can cure H. pylori infection in Rhesus monkeys, with resolution of abnormal histology and serologic responses. They suggest that this preclinical animal model is useful for testing new anti-H. pylori therapies. JF - Journal of gastroenterology AU - Dubois, A AU - Berg, D E AU - Fiala, N AU - Heman-Ackah, L M AU - Perez-Perez, G I AU - Blaser, M J AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 18 EP - 22 VL - 33 IS - 1 SN - 0944-1174, 0944-1174 KW - Index Medicus KW - National Library of Medicine KW - Drug Therapy, Combination KW - Endoscopy, Gastrointestinal KW - Amoxicillin -- therapeutic use KW - Animals KW - Macaca mulatta KW - Penicillins -- therapeutic use KW - Gastritis -- drug therapy KW - Male KW - Anti-Bacterial Agents -- therapeutic use KW - Helicobacter pylori KW - Enzyme Inhibitors -- therapeutic use KW - Bismuth -- therapeutic use KW - Helicobacter Infections -- drug therapy KW - Anti-Ulcer Agents -- therapeutic use KW - Omeprazole -- therapeutic use KW - Salicylates -- therapeutic use KW - Organometallic Compounds -- therapeutic use KW - Clarithromycin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85418780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology&rft.atitle=Cure+of+Helicobacter+pylori+infection+by+omeprazole-clarithromycin-based+therapy+in+non-human+primates.&rft.au=Dubois%2C+A%3BBerg%2C+D+E%3BFiala%2C+N%3BHeman-Ackah%2C+L+M%3BPerez-Perez%2C+G+I%3BBlaser%2C+M+J&rft.aulast=Dubois&rft.aufirst=A&rft.date=1998-02-01&rft.volume=33&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology&rft.issn=09441174&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Quarterly update. AN - 79935954; 9624945 JF - CRNA : the clinical forum for nurse anesthetists AU - McAuliffe, M S AU - Hartshorn, E A AD - Uniformed Services University of the Health Sciences, Graduate School of Nursing, Nurse Anesthesia Program, Bethesda, MD, USA. Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 33 EP - 36 VL - 9 IS - 1 SN - 1048-2687, 1048-2687 KW - Analgesics KW - 0 KW - Anesthetics KW - Nursing KW - Drug Interactions KW - Humans KW - Anesthetics -- pharmacology KW - Analgesics -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79935954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CRNA+%3A+the+clinical+forum+for+nurse+anesthetists&rft.atitle=Quarterly+update.&rft.au=McAuliffe%2C+M+S%3BHartshorn%2C+E+A&rft.aulast=McAuliffe&rft.aufirst=M&rft.date=1998-02-01&rft.volume=9&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=CRNA+%3A+the+clinical+forum+for+nurse+anesthetists&rft.issn=10482687&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-06-25 N1 - Date created - 1998-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A randomized, double-blind crossover trial of sertraline in women with chronic pelvic pain. AN - 79770562; 9532549 AB - The efficacy of antidepressants as analgesics for a range of chronic pain problems is well documented. However, a controlled trial of an antidepressant for women with chronic pelvic pain has not yet been published. We randomized 23 women from a general gynecology clinic to either double-blind sertraline or placebo. Measures of psychological function, pain, and functional disability were taken at baseline and 6 weeks. After a 2-week washout, the groups were crossed-over and the same measures were done over the next 6 weeks. There were no significant improvements in pain or functional disability noted on sertraline compared to placebo. Studies involving larger samples of patients are needed to confirm these findings. JF - Journal of psychosomatic research AU - Engel, C C AU - Walker, E A AU - Engel, A L AU - Bullis, J AU - Armstrong, A AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. cengel@pobox.com Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 203 EP - 207 VL - 44 IS - 2 SN - 0022-3999, 0022-3999 KW - Serotonin Uptake Inhibitors KW - 0 KW - 1-Naphthylamine KW - 9753I242R5 KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - Double-Blind Method KW - Depressive Disorder -- etiology KW - Humans KW - Adult KW - Cross-Over Studies KW - Pain Measurement KW - Middle Aged KW - Chronic Disease KW - Female KW - 1-Naphthylamine -- analogs & derivatives KW - Pelvic Pain -- drug therapy KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Pelvic Pain -- psychology KW - 1-Naphthylamine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79770562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychosomatic+research&rft.atitle=A+randomized%2C+double-blind+crossover+trial+of+sertraline+in+women+with+chronic+pelvic+pain.&rft.au=Engel%2C+C+C%3BWalker%2C+E+A%3BEngel%2C+A+L%3BBullis%2C+J%3BArmstrong%2C+A&rft.aulast=Engel&rft.aufirst=C&rft.date=1998-02-01&rft.volume=44&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychosomatic+research&rft.issn=00223999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-07 N1 - Date created - 1998-07-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Psychosom Res. 1998 Feb;44(2):197-201 [9532548] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental regulation of Salmonella typhi invasion-defective mutants. AN - 79671098; 9453627 AB - Salmonella typhi is the etiologic agent of human typhoid. During infection, S. typhi adheres to and invades epithelial and M cells that line the distal ileum. To survive in the human host, S. typhi must overcome numerous complex extracellular and intracellular environments. Since relatively little is known about S. typhi pathogenesis, studies were initiated to identify S. typhi genes involved in the early steps of interaction with the host and to evaluate the environmental regulation of these genes. In the present study, TnphoA mutagenesis was used to study these early steps. We isolated 16 Salmonella typhi TnphoA mutants that were defective for both adherence and invasion of the human small intestinal epithelial cell line Int407. Twelve of sixteen mutations were identified in genes homologous to the S. typhimurium invG and prgH genes, which are known to be involved in the type III secretion pathway of virulence proteins. Two additional insertions were identified in genes sharing homology with the cpxA and damX genes from Escherichia coli K-12, and two uncharacterized invasion-deficient mutants were nonmotile. Gene expression of TnphoA fusions was examined in response to environmental stimuli. We found that the cpxA, invG, and prgH genes were induced when grown under conditions of high osmolarity (0.3 M NaCl). Expression of invG and prgH genes was optimal at pH 6.5 and strongly reduced at low pH (5.0). Transcription of both invG and prgH TnphoA gene fusions was initiated during the late logarithmic growth phase and was induced under anaerobic conditions. Finally, we show that both invG and prgH genes appear to be regulated by DNA supercoiling, a mechanism influenced by environmental factors. These results are the first to demonstrate that in S. typhi, (i) the prgH and cpxA genes are osmoregulated, (ii) the invG gene is induced under low oxygen conditions, (iii) the invG gene is pH regulated and growth phase dependent, and (iv) the prgH gene appears to be regulated by DNA supercoiling. Since our experimental conditions were designed to mimic the in vivo environmental milieu, our results suggest that specific environmental conditions act as signals to induce the expression of S. typhi invasion genes. JF - Infection and immunity AU - Leclerc, G J AU - Tartera, C AU - Metcalf, E S AD - Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 682 EP - 691 VL - 66 IS - 2 SN - 0019-9567, 0019-9567 KW - DNA Transposable Elements KW - 0 KW - Topoisomerase II Inhibitors KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Oxygen -- pharmacology KW - Hydrogen-Ion Concentration KW - Humans KW - Epithelial Cells -- microbiology KW - Mutation KW - Intestine, Small -- microbiology KW - Gene Expression Regulation, Bacterial KW - Salmonella typhi -- pathogenicity KW - Salmonella typhi -- genetics KW - Salmonella typhi -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79671098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Environmental+regulation+of+Salmonella+typhi+invasion-defective+mutants.&rft.au=Leclerc%2C+G+J%3BTartera%2C+C%3BMetcalf%2C+E+S&rft.aulast=Leclerc&rft.aufirst=G&rft.date=1998-02-01&rft.volume=66&rft.issue=2&rft.spage=682&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-02-12 N1 - Date created - 1998-02-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Microbiol. 1993 Jan;7(1):59-68 [8437520] Mol Microbiol. 1993 Jan;7(1):89-98 [8382333] Infect Immun. 1993 Jul;61(7):3084-9 [8514418] J Bacteriol. 1993 Jul;175(14):4475-84 [8392513] Gene. 1993 Dec 22;136(1-2):227-30 [8294007] Cell. 1994 Feb 25;76(4):717-24 [8124710] Infect Immun. 1990 Jun;58(6):2014-6 [1971262] Proc Natl Acad Sci U S A. 1990 Jun;87(11):4304-8 [2349239] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] Mol Gen Genet. 1990 Aug;223(1):156-8 [2259337] Infect Immun. 1991 Jan;59(1):437-40 [1987056] Infect Immun. 1991 Mar;59(3):745-9 [1997427] Mol Microbiol. 1991 Feb;5(2):401-7 [1645840] J Bacteriol. 1991 Aug;173(16):4994-5009 [1860816] Infect Immun. 1991 Sep;59(9):2901-8 [1879916] J Bacteriol. 1992 Jan;174(1):1-7 [1729202] Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1847-51 [1311853] Microb Pathog. 1992 Feb;12(2):145-51 [1584006] J Bacteriol. 1992 Jun;174(11):3499-507 [1592805] J Bacteriol. 1992 Jul;174(13):4338-49 [1624429] Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5976-80 [1631083] J Bacteriol. 1992 Nov;174(21):6878-85 [1400238] Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10079-83 [1438196] Mol Microbiol. 1992 Nov;6(21):3077-87 [1360615] Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11978-82 [1465428] Mol Microbiol. 1994 Jan;11(1):123-35 [7511772] J Bacteriol. 1994 Aug;176(15):4501-10 [8045880] Infect Immun. 1994 Sep;62(9):3745-52 [8063389] Infect Immun. 1994 Sep;62(9):3984-93 [8063417] Infect Immun. 1994 Oct;62(10):4135-9 [7927667] Mol Microbiol. 1994 Aug;13(4):555-68 [7997169] Annu Rev Microbiol. 1994;48:53-80 [7826018] Genes Dev. 1995 Feb 15;9(4):387-98 [7883164] FEMS Microbiol Lett. 1995 Feb 1;126(1):97-101 [7896085] Mol Microbiol. 1995 Jan;15(1):25-38 [7752894] Res Microbiol. 1995 Jan;146(1):17-20 [7754225] Mol Gen Genet. 1995 Jun 10;247(5):546-54 [7603433] J Bacteriol. 1995 Jul;177(14):3965-71 [7608068] Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7996-8000 [7644527] J Bacteriol. 1995 Sep;177(17):5062-9 [7665485] Mol Microbiol. 1995 Jul;17(1):155-67 [7476202] Mol Microbiol. 1995 Jul;17(1):169-81 [7476203] J Bacteriol. 1995 Dec;177(24):7078-85 [8522512] Mol Microbiol. 1995 Aug;17(3):461-70 [8559065] Mol Microbiol. 1995 Aug;17(4):781-9 [8801431] Cell. 1996 Jan 12;84(1):165-74 [8548821] J Bacteriol. 1996 Feb;178(4):1061-9 [8576039] Infect Immun. 1996 May;64(5):1862-5 [8613405] Infect Immun. 1996 Jun;64(6):2088-94 [8675311] Mol Microbiol. 1996 Apr;20(2):263-71 [8733226] Mol Microbiol. 1988 Nov;2(6):757-66 [2850443] Microb Pathog. 1988 May;4(5):345-57 [3071655] Proc Natl Acad Sci U S A. 1989 Jul;86(13):5173-7 [2662196] Proc Natl Acad Sci U S A. 1989 Aug;86(16):6383-7 [2548211] Mol Gen Genet. 1989 May;217(1):85-96 [2549371] Mol Microbiol. 1989 Jul;3(7):933-42 [2677605] Mol Microbiol. 1989 Sep;3(9):1191-201 [2552264] J Bacteriol. 1990 Feb;172(2):771-8 [2404956] Mol Microbiol. 1989 Dec;3(12):1833-41 [2695752] Nucleic Acids Res. 1990 Mar 25;18(6):1648 [2183200] J Bacteriol. 1990 May;172(5):2433-8 [2185220] Infect Immun. 1990 Jun;58(6):1879-85 [2160435] Mol Plant Microbe Interact. 1992 Sep-Oct;5(5):384-9 [1472716] Mol Microbiol. 1995 Nov;18(3):479-90 [8748032] Mol Microbiol. 1995 Nov;18(4):715-27 [8817493] Mol Microbiol. 1996 Nov;22(4):703-14 [8951817] Mol Microbiol. 1996 Nov;22(4):715-27 [8951818] Infect Immun. 1997 Feb;65(2):395-404 [9009288] Infect Immun. 1998 May;66(5):2310-8 [9573122] EMBO J. 1993 Oct;12(10):3779-87 [8404849] N Engl J Med. 1970 Sep 24;283(13):686-91 [4916913] N Engl J Med. 1970 Oct 1;283(14):739-46 [4916916] Infect Immun. 1974 Oct;10(4):816-22 [4214784] J Infect Dis. 1976 Jan;133(1):72-8 [1107437] Proc Natl Acad Sci U S A. 1976 Dec;73(12):4474-8 [794878] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Infect Immun. 1982 Dec;38(3):948-52 [7152679] Cell. 1983 Nov;35(1):253-63 [6627396] Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 [6546423] Rev Infect Dis. 1986 May-Jun;8(3):329-49 [3726393] Microbiol Immunol. 1986;30(12):1225-37 [3553868] Cell. 1987 Jun 5;49(5):579-81 [3555840] Microbiol Immunol. 1987;31(1):1-11 [2438540] Cell. 1987 Aug 28;50(5):769-78 [3304658] J Bacteriol. 1988 Jun;170(6):2575-83 [2836362] J Bacteriol. 1988 Jun;170(6):2816-26 [2836373] Infect Immun. 1988 Aug;56(8):1967-73 [2840399] Proc Natl Acad Sci U S A. 1988 Dec;85(23):9317-21 [3057506] FEMS Microbiol Lett. 1992 Dec 1;78(2-3):271-6 [1490610] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vertical profiles of longshore currents and related bed shear stress and bottom roughness AN - 52483060; 1999-033958 JF - Journal of Geophysical Research AU - Garcez Faria, A F AU - Thornton, E B AU - Stanton, T P AU - Soares, C V AU - Lippmann, T C Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 3117 EP - 3232 PB - American Geophysical Union, Washington, DC VL - 103 IS - C2 SN - 0148-0227, 0148-0227 KW - United States KW - shear stress KW - nearshore sedimentation KW - longshore currents KW - Dare County North Carolina KW - DUCK94 KW - beaches KW - boundary layer KW - currents KW - sediment transport KW - statistical analysis KW - sedimentation KW - roughness KW - bars KW - Duck North Carolina KW - bottom currents KW - ocean currents KW - depth KW - least-squares analysis KW - North Carolina KW - shear KW - North Atlantic KW - coastal sedimentation KW - regression analysis KW - Atlantic Ocean KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52483060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Vertical+profiles+of+longshore+currents+and+related+bed+shear+stress+and+bottom+roughness&rft.au=Garcez+Faria%2C+A+F%3BThornton%2C+E+B%3BStanton%2C+T+P%3BSoares%2C+C+V%3BLippmann%2C+T+C&rft.aulast=Garcez+Faria&rft.aufirst=A&rft.date=1998-02-01&rft.volume=103&rft.issue=C2&rft.spage=3117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/ L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 52 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; bars; beaches; bottom currents; boundary layer; coastal sedimentation; currents; Dare County North Carolina; depth; Duck North Carolina; DUCK94; least-squares analysis; longshore currents; nearshore sedimentation; North Atlantic; North Carolina; ocean currents; regression analysis; roughness; sediment transport; sedimentation; shear; shear stress; statistical analysis; United States ER - TY - JOUR T1 - Observations of sand bar evolution on a natural beach AN - 50161231; 1999-033957 AB - Waves, currents, and the location of the seafloor were measured on a barred beach for about 2 months at nine locations along a cross-shore transect extending 255 m from 1 to 4 m water depth. The seafloor location was measured nearly continuously, even in the surf zone during storms, with sonar altimeters mounted on fixed frames. The crest of a sand bar initially located about 60 m from the shoreline moved 130 m offshore (primarily when the offshore significant wave height exceeded about 2 m), with 1.5 m of erosion near the initial location and 1 m of accretion at the final location. An energetics-type sediment transport model driven by locally measured near-bottom currents predicts the observed offshore bar migration, but not the slow onshore migration observed during low-energy wave conditions. The predicted offshore bar migration is driven primarily by cross-shore gradients in predicted suspended sediment transport associated with quasi-steady, near-bottom, offshore flows. These strong (> 50 cm/s) currents, intensified near the bar crest by wave breaking, are predicted to cause erosion on the shoreward slope of the bar and deposition on the seaward side. The feedback amoung morphology, waves, circulation, and sediment transport thus forces offshore bar migration during storms. Copyright 1998 by the American Geophysical Union. JF - Journal of Geophysical Research AU - Gallagher, Edith L AU - Elgar, Steve AU - Guza, R T Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 3203 EP - 3215 PB - American Geophysical Union, Washington, DC VL - 103 IS - C2 SN - 0148-0227, 0148-0227 KW - United States KW - slopes KW - Dare County North Carolina KW - suspended materials KW - marine transport KW - storm environment KW - beaches KW - sediments KW - currents KW - sand KW - barrier islands KW - shore features KW - monitoring KW - sediment transport KW - high-energy environment KW - clastic sediments KW - sedimentation KW - bars KW - Duck North Carolina KW - ocean currents KW - models KW - North Carolina KW - geomorphology KW - North Atlantic KW - coastal sedimentation KW - energy KW - Atlantic Ocean KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50161231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Observations+of+sand+bar+evolution+on+a+natural+beach&rft.au=Gallagher%2C+Edith+L%3BElgar%2C+Steve%3BGuza%2C+R+T&rft.aulast=Gallagher&rft.aufirst=Edith&rft.date=1998-02-01&rft.volume=103&rft.issue=C2&rft.spage=3203&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F97JC02765 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 53 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; barrier islands; bars; beaches; clastic sediments; coastal sedimentation; currents; Dare County North Carolina; Duck North Carolina; energy; geomorphology; high-energy environment; marine transport; models; monitoring; North Atlantic; North Carolina; ocean currents; sand; sediment transport; sedimentation; sediments; shore features; slopes; storm environment; suspended materials; United States DO - http://dx.doi.org/10.1029/97JC02765 ER - TY - JOUR T1 - Modeling the normal and neoplastic cell cycle with "realistic Boolean genetic networks": their application for understanding carcinogenesis and assessing therapeutic strategies. AN - 80059347; 9697172 AB - In this paper we show how Boolean genetic networks could be used to address complex problems in cancer biology. First, we describe a general strategy to generate Boolean genetic networks that incorporate all relevant biochemical and physiological parameters and cover all of their regulatory interactions in a deterministic manner. Second, we introduce "realistic Boolean genetic networks" that produce time series measurements very similar to those detected in actual biological systems. Third, we outline a series of essential questions related to cancer biology and cancer therapy that could be addressed by the use of "realistic Boolean genetic network" modeling. JF - Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing AU - Szallasi, Z AU - Liang, S AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. zszallas@mx3.usuhs.mil Y1 - 1998 PY - 1998 DA - 1998 SP - 66 EP - 76 SN - 2335-6936, 2335-6936 KW - Index Medicus KW - Logic KW - Probability KW - Humans KW - Neoplasms -- pathology KW - Computer Simulation KW - Models, Genetic KW - Neoplasms -- prevention & control KW - Neoplasms -- therapy KW - Cell Cycle -- genetics KW - Nerve Net KW - Neoplasms -- genetics KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80059347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pacific+Symposium+on+Biocomputing.+Pacific+Symposium+on+Biocomputing&rft.atitle=Modeling+the+normal+and+neoplastic+cell+cycle+with+%22realistic+Boolean+genetic+networks%22%3A+their+application+for+understanding+carcinogenesis+and+assessing+therapeutic+strategies.&rft.au=Szallasi%2C+Z%3BLiang%2C+S&rft.aulast=Szallasi&rft.aufirst=Z&rft.date=1998-01-01&rft.volume=&rft.issue=&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Pacific+Symposium+on+Biocomputing.+Pacific+Symposium+on+Biocomputing&rft.issn=23356936&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-10-27 N1 - Date created - 1998-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Novel insecticidal peptides from Tegenaria agrestis spider venom may have a direct effect on the insect central nervous system. AN - 79881013; 9589602 AB - Fractionation of venom from an agelenid spider, Tegenaria agrestis, resulted in the isolation of a family of three peptides with potent insecticidal activity. These peptide toxins, TaITX-1, -2, and -3, whose sequences were revealed from cloned cDNAs, each consist of 50 amino acid residues, six of which are cysteines. They appear to be amidated at their C-termini and exhibit greater than 90% sequence identity. Unlike other reported spider toxins, the TaI toxins are processed from precursors containing no propeptide sequences. In lepidopteran larvae and corn rootworm beetles, the insecticidal Tegenaria toxins caused an unusual excitatory symptomatology with 50% paralytic doses ranging from 0.23 to 2.6 nmol/g. In a series of electrophysiological experiments performed in house fly larvae, these toxins caused an elevated rate of firing from central nervous system neurons. No significant effects were found when any peripheral sensory or motor systems were examined. Thus, it appears that the TaI toxins may act in a fashion not previously reported for insecticidal peptide toxins; they may act directly on the insect central nervous system. JF - Archives of insect biochemistry and physiology AU - Johnson, J H AU - Bloomquist, J R AU - Krapcho, K J AU - Kral, R M AU - Trovato, R AU - Eppler, K G AU - Morgan, T K AU - DelMar, E G AD - NPS Pharmaceuticals, Salt Lake City, Utah 84108, USA. jdelmar@npsp.com Y1 - 1998 PY - 1998 DA - 1998 SP - 19 EP - 31 VL - 38 IS - 1 SN - 0739-4462, 0739-4462 KW - DNA, Complementary KW - 0 KW - Insecticides KW - Spider Venoms KW - TaITX-1 KW - TaITX-2 KW - TaITX-3 KW - Index Medicus KW - Insecticides -- toxicity KW - Animals KW - Chemical Fractionation KW - Biological Assay KW - Mice KW - Amino Acid Sequence KW - Electrophysiology KW - Sequence Analysis, DNA KW - Mice, Inbred BALB C KW - Cloning, Molecular KW - Polymerase Chain Reaction KW - Base Sequence KW - Sequence Alignment KW - Molecular Sequence Data KW - Central Nervous System -- drug effects KW - DNA, Complementary -- chemistry KW - Insecticides -- chemistry KW - Insecticides -- isolation & purification KW - Male KW - Moths -- drug effects KW - Spider Venoms -- toxicity KW - Spider Venoms -- chemistry KW - Spider Venoms -- isolation & purification KW - Spiders -- physiology KW - Houseflies -- drug effects KW - Beetles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79881013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+insect+biochemistry+and+physiology&rft.atitle=Novel+insecticidal+peptides+from+Tegenaria+agrestis+spider+venom+may+have+a+direct+effect+on+the+insect+central+nervous+system.&rft.au=Johnson%2C+J+H%3BBloomquist%2C+J+R%3BKrapcho%2C+K+J%3BKral%2C+R+M%3BTrovato%2C+R%3BEppler%2C+K+G%3BMorgan%2C+T+K%3BDelMar%2C+E+G&rft.aulast=Johnson&rft.aufirst=J&rft.date=1998-01-01&rft.volume=38&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Archives+of+insect+biochemistry+and+physiology&rft.issn=07394462&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-06-10 N1 - Date created - 1998-06-10 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AJ224127; GENBANK; AJ224128; AJ224129 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deconstructing equity, autonomy, and ethical analysis. AN - 73918050; 9750981 JF - The Journal of clinical ethics AU - Howe, E G AD - Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Y1 - 1998 PY - 1998 DA - 1998 SP - 99 EP - 107 VL - 9 IS - 2 SN - 1046-7890, 1046-7890 KW - Anti-HIV Agents KW - 0 KW - Zidovudine KW - 4B9XT59T7S KW - Bioethics KW - Index Medicus KW - AIDS/HIV KW - Professional Patient Relationship KW - Ethics, Clinical KW - Vulnerable Populations KW - Dose-Response Relationship, Drug KW - Humans KW - Resource Allocation KW - Infant, Newborn KW - Social Values KW - Paternalism KW - Persons KW - Pregnancy KW - Control Groups KW - Pregnant Women KW - Treatment Outcome KW - Informed Consent -- legislation & jurisprudence KW - Siblings KW - Cultural Diversity KW - Female KW - Mentally Ill Persons KW - Infectious Disease Transmission, Vertical -- prevention & control KW - Randomized Controlled Trials as Topic -- legislation & jurisprudence KW - HIV Infections -- transmission KW - Anti-HIV Agents -- administration & dosage KW - Anti-HIV Agents -- adverse effects KW - Zidovudine -- administration & dosage KW - Pregnancy Complications, Infectious -- drug therapy KW - Zidovudine -- adverse effects KW - HIV Infections -- drug therapy KW - Ethics, Medical KW - Developing Countries KW - Ethical Analysis KW - Personal Autonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73918050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+ethics&rft.atitle=Deconstructing+equity%2C+autonomy%2C+and+ethical+analysis.&rft.au=Howe%2C+E+G&rft.aulast=Howe&rft.aufirst=E&rft.date=1998-01-01&rft.volume=9&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+ethics&rft.issn=10467890&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-12-30 N1 - Date created - 1998-12-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Clin Ethics. 1998 Summer;9(2):167-72 [9750988] J Clin Ethics. 1998 Summer;9(2):156-66 [9750987] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Topical studies in oceanography; studies of the California current system; Part 1 AN - 52485375; 1999-035532 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography Y1 - 1998 PY - 1998 DA - 1998 SP - 1904 PB - Pergamon Press, Oxford - New York VL - 45 IS - 8-9 SN - 0967-0645, 0967-0645 KW - United States KW - East Pacific KW - upwelling KW - ocean circulation KW - California Current KW - Northeast Pacific KW - Central California KW - sedimentation KW - Santa Barbara Basin KW - California KW - marine sediments KW - North Pacific KW - Pacific Ocean KW - sediments KW - Monterey Canyon KW - sediment traps KW - productivity KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52485375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1998-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Topical+studies+in+oceanography%3B+studies+of+the+California+current+system%3B+Part+1&rft.title=Topical+studies+in+oceanography%3B+studies+of+the+California+current+system%3B+Part+1&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Document feature - illus. N1 - SuppNotes - Individual papers within scope are cited separately N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - California; California Current; Central California; East Pacific; marine sediments; Monterey Canyon; North Pacific; Northeast Pacific; ocean circulation; Pacific Ocean; productivity; Santa Barbara Basin; sediment traps; sedimentation; sediments; United States; upwelling ER - TY - JOUR T1 - Silica depletion in the thermocline of the glacial North Pacific; corollaries and implications AN - 52483681; 1999-035536 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Berger, W H AU - Lange, C B Y1 - 1998 PY - 1998 DA - 1998 SP - 1885 EP - 1904 PB - Pergamon Press, Oxford - New York VL - 45 IS - 8-9 SN - 0967-0645, 0967-0645 KW - silicates KW - silica minerals KW - laminations KW - opal KW - Equatorial Pacific KW - Santa Barbara Basin KW - temperature KW - nutrients KW - planar bedding structures KW - marine sediments KW - biogenic processes KW - thermocline KW - North Pacific KW - silica KW - Pacific Ocean KW - glacial environment KW - sediments KW - framework silicates KW - bathymetry KW - sedimentary structures KW - productivity KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52483681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Silica+depletion+in+the+thermocline+of+the+glacial+North+Pacific%3B+corollaries+and+implications&rft.au=Berger%2C+W+H%3BLange%2C+C+B&rft.aulast=Berger&rft.aufirst=W&rft.date=1998-01-01&rft.volume=45&rft.issue=8-9&rft.spage=1885&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 59 N1 - Document feature - illus. incl. geol. sketch map, sects. N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - bathymetry; biogenic processes; Equatorial Pacific; framework silicates; glacial environment; laminations; marine sediments; North Pacific; nutrients; opal; Pacific Ocean; planar bedding structures; productivity; Santa Barbara Basin; sedimentary structures; sediments; silica; silica minerals; silicates; temperature; thermocline ER - TY - JOUR T1 - Particle fluxes in a coastal upwelling zone; sediment trap results from Santa Barbara Basin, California AN - 52483655; 1999-035535 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Thunell, Robert C Y1 - 1998 PY - 1998 DA - 1998 SP - 1863 EP - 1884 PB - Pergamon Press, Oxford - New York VL - 45 IS - 8-9 SN - 0967-0645, 0967-0645 KW - United States KW - upwelling KW - detritus KW - Santa Barbara Basin KW - layered materials KW - California KW - marine sediments KW - mineral composition KW - sediments KW - terrigenous materials KW - particulate materials KW - depositional environment KW - sediment traps KW - ocean circulation KW - California Current KW - time series analysis KW - Central California KW - statistical analysis KW - sedimentation KW - geochemical cycle KW - provenance KW - biogenic processes KW - Southern California KW - coastal environment KW - anaerobic environment KW - bathymetry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52483655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Particle+fluxes+in+a+coastal+upwelling+zone%3B+sediment+trap+results+from+Santa+Barbara+Basin%2C+California&rft.au=Thunell%2C+Robert+C&rft.aulast=Thunell&rft.aufirst=Robert&rft.date=1998-01-01&rft.volume=45&rft.issue=8-9&rft.spage=1863&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 67 N1 - Document feature - illus. incl. sketch maps, 5 tables, block diag. N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - anaerobic environment; bathymetry; biogenic processes; California; California Current; Central California; coastal environment; depositional environment; detritus; geochemical cycle; layered materials; marine sediments; mineral composition; ocean circulation; particulate materials; provenance; Santa Barbara Basin; sediment traps; sedimentation; sediments; Southern California; statistical analysis; terrigenous materials; time series analysis; United States; upwelling ER - TY - JOUR T1 - Spatial and temporal dynamics in marine aggregate abundance, sinking rate and flux; Monterey Bay, central California AN - 52483621; 1999-035533 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Pilskaln, Cynthia H AU - Lehmann, Charlotte AU - Paduan, Jennifer B AU - Silver, Mary W Y1 - 1998 PY - 1998 DA - 1998 SP - 1803 EP - 1837 PB - Pergamon Press, Oxford - New York VL - 45 IS - 8-9 SN - 0967-0645, 0967-0645 KW - United States KW - oxygen KW - suspended materials KW - salinity KW - marine sedimentation KW - California KW - size distribution KW - marine sediments KW - Monterey Bay KW - dynamics KW - sediments KW - sediment traps KW - concentration KW - ocean circulation KW - California Current KW - in situ KW - time series analysis KW - Sea Projector Lamp KW - statistical analysis KW - sedimentation KW - rates KW - distribution KW - remotely operated vehicles KW - deposition KW - seasonal variations KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52483621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Spatial+and+temporal+dynamics+in+marine+aggregate+abundance%2C+sinking+rate+and+flux%3B+Monterey+Bay%2C+central+California&rft.au=Pilskaln%2C+Cynthia+H%3BLehmann%2C+Charlotte%3BPaduan%2C+Jennifer+B%3BSilver%2C+Mary+W&rft.aulast=Pilskaln&rft.aufirst=Cynthia&rft.date=1998-01-01&rft.volume=45&rft.issue=8-9&rft.spage=1803&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 54 N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - California; California Current; concentration; deposition; distribution; dynamics; in situ; marine sedimentation; marine sediments; Monterey Bay; ocean circulation; oxygen; rates; remotely operated vehicles; salinity; Sea Projector Lamp; seasonal variations; sediment traps; sedimentation; sediments; size distribution; statistical analysis; suspended materials; time series analysis; United States ER - TY - JOUR T1 - Exploratory observations of marine aggregates at sub-euphotic depths AN - 52481156; 1999-035534 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Silver, Mary W AU - Coale, Susan L AU - Pilskaln, Cynthia H AU - Chavez, Francisco P Y1 - 1998 PY - 1998 DA - 1998 SP - 1839 EP - 1861 PB - Pergamon Press, Oxford - New York VL - 45 IS - 8-9 SN - 0967-0645, 0967-0645 KW - United States KW - continental margin KW - aggregate KW - phytoplankton KW - sedimentation KW - rates KW - deep-sea environment KW - plankton KW - detritus KW - marine sedimentation KW - California KW - provenance KW - marine sediments KW - Monterey Bay KW - marine environment KW - sediments KW - anaerobic environment KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52481156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Exploratory+observations+of+marine+aggregates+at+sub-euphotic+depths&rft.au=Silver%2C+Mary+W%3BCoale%2C+Susan+L%3BPilskaln%2C+Cynthia+H%3BChavez%2C+Francisco+P&rft.aulast=Silver&rft.aufirst=Mary&rft.date=1998-01-01&rft.volume=45&rft.issue=8-9&rft.spage=1839&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 73 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - aggregate; anaerobic environment; California; continental margin; deep-sea environment; detritus; marine environment; marine sedimentation; marine sediments; Monterey Bay; phytoplankton; plankton; provenance; rates; sedimentation; sediments; United States ER - TY - JOUR T1 - Improvement of estuarine and coastal modeling using high-order difference schemes AN - 52402628; 2000-011393 AB - How to reduce the computational error is a key issue of using sigma -coordinate coastal ocean models. Due to the fact that the higher the order of the difference scheme, the less the truncation error and the more complicated the computation, we introduce three sixth-order difference schemes (ordinary, compact, and combined compact) for the sigma -coordinate coastal models in order to reduce error without increasing much complexity of the computation. After the analytical error estimation, the Semi-Spectral Primitive Equation Model (SPEM) is used to demonstrate the benefit of using these schemes and to compare the difference among the three six-order schemes. Over a wide range of parameter space as well as a great parametric domain of numerical stability, the ordinary sixth-order scheme is shown to have error reductions by factors of 50 comparing to the second-order difference scheme. Among the sixth-order schemes, the compact scheme reduces error by more than 50-55% comparing to the ordinary scheme, and the combined compact scheme reduces error by more than 60% comparing to the compact scheme. JF - Estuarine and Coastal Modeling. Proceedings of the ... International Conference AU - Chu, Peter C AU - Fan, Chenwu A2 - Spaulding, Malcolm L. A2 - Blumberg, Alan F. Y1 - 1998 PY - 1998 DA - 1998 SP - 28 EP - 34 PB - ASCE American Society of Civil Engineers, New York, NY VL - 5 KW - hydrology KW - sea water KW - mathematical methods KW - surface water KW - hydrodynamics KW - coastal environment KW - mathematical models KW - estuarine environment KW - accuracy KW - 21:Hydrogeology KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52402628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuarine+and+Coastal+Modeling.+Proceedings+of+the+...+International+Conference&rft.atitle=Improvement+of+estuarine+and+coastal+modeling+using+high-order+difference+schemes&rft.au=Chu%2C+Peter+C%3BFan%2C+Chenwu&rft.aulast=Chu&rft.aufirst=Peter&rft.date=1998-01-01&rft.volume=5&rft.issue=&rft.spage=28&rft.isbn=0784403503&rft.btitle=&rft.title=Estuarine+and+Coastal+Modeling.+Proceedings+of+the+...+International+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 5th international conference on Estuarine and coastal modeling N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 13 N1 - PubXState - NY N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #03869 N1 - SubjectsTermNotLitGenreText - accuracy; coastal environment; estuarine environment; hydrodynamics; hydrology; mathematical methods; mathematical models; sea water; surface water ER - TY - JOUR T1 - IronEx-I, an in situ iron-enrichment experiment; experimental design, implementation and results AN - 52337787; 2000-053314 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Coale, Kenneth H AU - Johnson, Kenneth S AU - Fitzwater, Steve E AU - Blain, Stephane P G AU - Stanton, Tim P AU - Coley, Teresa L Y1 - 1998 PY - 1998 DA - 1998 SP - 919 EP - 945 PB - Pergamon, Oxford VL - 45 IS - 6 SN - 0967-0645, 0967-0645 KW - East Pacific KW - currents KW - upwelling KW - concentration KW - sea water KW - in situ KW - equatorial region KW - enrichment KW - surface water KW - East Pacific Ocean Islands KW - hydrochemistry KW - ocean currents KW - iron KW - nutrients KW - Galapagos Islands KW - sampling KW - metals KW - Pacific Ocean KW - tracers KW - nitrate ion KW - geochemistry KW - 07:Oceanography KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52337787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=IronEx-I%2C+an+in+situ+iron-enrichment+experiment%3B+experimental+design%2C+implementation+and+results&rft.au=Coale%2C+Kenneth+H%3BJohnson%2C+Kenneth+S%3BFitzwater%2C+Steve+E%3BBlain%2C+Stephane+P+G%3BStanton%2C+Tim+P%3BColey%2C+Teresa+L&rft.aulast=Coale&rft.aufirst=Kenneth&rft.date=1998-01-01&rft.volume=45&rft.issue=6&rft.spage=919&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 74 N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - concentration; currents; East Pacific; East Pacific Ocean Islands; enrichment; equatorial region; Galapagos Islands; geochemistry; hydrochemistry; in situ; iron; metals; nitrate ion; nutrients; ocean currents; Pacific Ocean; sampling; sea water; surface water; tracers; upwelling ER - TY - JOUR T1 - Physical evolution of the IronEx-I open ocean tracer patch AN - 52335553; 2000-053315 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Stanton, Tim P AU - Law, C S AU - Watson, A J Y1 - 1998 PY - 1998 DA - 1998 SP - 947 EP - 975 PB - Pergamon, Oxford VL - 45 IS - 6 SN - 0967-0645, 0967-0645 KW - currents KW - Global Positioning System KW - diffusion KW - sea water KW - sulfur fluorides KW - enrichment KW - statistical analysis KW - Equatorial Pacific KW - advection KW - iron KW - time scales KW - spatial distribution KW - IronEx-1 KW - transport KW - sampling KW - time factor KW - metals KW - Pacific Ocean KW - tracers KW - corrections KW - bathymetry KW - productivity KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52335553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Physical+evolution+of+the+IronEx-I+open+ocean+tracer+patch&rft.au=Stanton%2C+Tim+P%3BLaw%2C+C+S%3BWatson%2C+A+J&rft.aulast=Stanton&rft.aufirst=Tim&rft.date=1998-01-01&rft.volume=45&rft.issue=6&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 13 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - advection; bathymetry; corrections; currents; diffusion; enrichment; Equatorial Pacific; Global Positioning System; iron; IronEx-1; metals; Pacific Ocean; productivity; sampling; sea water; spatial distribution; statistical analysis; sulfur fluorides; time factor; time scales; tracers; transport ER - TY - JOUR T1 - Sulphur hexafluoride as a tracer of biogeochemical and physical processes in an open-ocean iron fertilisation experiment AN - 52332207; 2000-053316 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Law, C S AU - Watson, A J AU - Liddicoat, M I AU - Stanton, Tim P Y1 - 1998 PY - 1998 DA - 1998 SP - 977 EP - 994 PB - Pergamon, Oxford VL - 45 IS - 6 SN - 0967-0645, 0967-0645 KW - solute transport KW - Global Positioning System KW - sea water KW - sulfur hexafluoride KW - in situ KW - biochemistry KW - surface water KW - statistical analysis KW - Equatorial Pacific KW - salinity KW - advection KW - iron KW - nutrients KW - sampling KW - metals KW - marine environment KW - Pacific Ocean KW - tracers KW - nitrate ion KW - chemical ratios KW - productivity KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52332207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Sulphur+hexafluoride+as+a+tracer+of+biogeochemical+and+physical+processes+in+an+open-ocean+iron+fertilisation+experiment&rft.au=Law%2C+C+S%3BWatson%2C+A+J%3BLiddicoat%2C+M+I%3BStanton%2C+Tim+P&rft.aulast=Law&rft.aufirst=C&rft.date=1998-01-01&rft.volume=45&rft.issue=6&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 31 N1 - Document feature - illus. N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - advection; biochemistry; chemical ratios; Equatorial Pacific; Global Positioning System; in situ; iron; marine environment; metals; nitrate ion; nutrients; Pacific Ocean; productivity; salinity; sampling; sea water; solute transport; statistical analysis; sulfur hexafluoride; surface water; tracers ER - TY - JOUR T1 - Lake Tahoe bathymetry from hyperspectral imagery AN - 51922718; 2003-080427 JF - Eos, Transactions, American Geophysical Union AU - Garfield, N AU - Olsen, R C AU - Stuffle, L D AU - Anonymous Y1 - 1998 PY - 1998 DA - 1998 SP - 169 PB - American Geophysical Union, Washington, DC VL - 79 IS - 17, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - hydrology KW - imagery KW - principal components analysis KW - statistical analysis KW - HYDICE data KW - geophysical methods KW - limnology KW - lacustrine environment KW - bathymetry KW - reflectance KW - Lake Tahoe KW - 21:Hydrogeology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51922718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Lake+Tahoe+bathymetry+from+hyperspectral+imagery&rft.au=Garfield%2C+N%3BOlsen%2C+R+C%3BStuffle%2C+L+D%3BAnonymous&rft.aulast=Garfield&rft.aufirst=N&rft.date=1998-01-01&rft.volume=79&rft.issue=17%2C+Suppl.&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1998 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - bathymetry; geophysical methods; HYDICE data; hydrology; imagery; lacustrine environment; Lake Tahoe; limnology; principal components analysis; reflectance; statistical analysis; United States ER - TY - JOUR T1 - Megaripple migration in a natural surf zone AN - 1844921699; 2016-099752 AB - Observations based on the quantitative measurement of migration rate and direction are presented of the surf zone on a beach in North Carolina, USA. These indicate that megaripples (bedform appearing in the surf zone of sandy coasts, and averaging 0.1-0.5 m high, with wavelength of 1-5 m), do not migrate in the direction of the vector sum of the currents, but are aligned so that sediment transport normal to the bedform crest is maximized. Megaripple migration in the surf zone is caused by both mean and wave flows. JF - Nature (London) AU - Gallagher, E L AU - Elgar, S AU - Thornton, E B Y1 - 1998 PY - 1998 DA - 1998 SP - 165 EP - 168 PB - Macmillan Journals, London VL - 394 IS - 6689 SN - 0028-0836, 0028-0836 KW - currents KW - sand KW - surf zones KW - clastic sediments KW - waves KW - numerical analysis KW - ocean currents KW - flume studies KW - bedforms KW - oceanography KW - bedding plane irregularities KW - sediments KW - megaripples KW - sedimentary structures KW - 06A:Sedimentary petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844921699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+%28London%29&rft.atitle=Megaripple+migration+in+a+natural+surf+zone&rft.au=Gallagher%2C+E+L%3BElgar%2C+S%3BThornton%2C+E+B&rft.aulast=Gallagher&rft.aufirst=E&rft.date=1998-01-01&rft.volume=394&rft.issue=6689&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Nature+%28London%29&rft.issn=00280836&rft_id=info:doi/10.1038%2F28139 L2 - http://www.nature.com/nature/index.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 2016-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2016-12-01 N1 - CODEN - NATUAS N1 - SubjectsTermNotLitGenreText - bedding plane irregularities; bedforms; clastic sediments; currents; flume studies; megaripples; numerical analysis; ocean currents; oceanography; sand; sedimentary structures; sediments; surf zones; waves DO - http://dx.doi.org/10.1038/28139 ER - TY - JOUR T1 - Biological Warfare Threats in Perspective AN - 17579945; 4553885 AB - At least ten countries are considered to have current biological weapons programs. These programs differ in scope and size. There is no evidence to suggest proliferation in the number of states parties engaged in biological weapons development. There is legitimate concern, however, that the sophistication of programs may be growing and that terrorist groups could acquire biological weapons. Thus, the threat that biological weapons could be used as agents of terrorism or warfare must be taken seriously. JF - Critical Reviews in Microbiology AU - Carus, W S AD - Center for Counterproliferation Research, National Defense University, Fort Leslie J. McNair, Washington, DC 20319, USA, caruss@ndu.edu Y1 - 1998 PY - 1998 DA - 1998 SP - 149 EP - 155 VL - 24 IS - 3 SN - 1040-841X, 1040-841X KW - biological warfare KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Reviews KW - A 01118:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17579945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Microbiology&rft.atitle=Biological+Warfare+Threats+in+Perspective&rft.au=Carus%2C+W+S&rft.aulast=Carus&rft.aufirst=W&rft.date=1998-01-01&rft.volume=24&rft.issue=3&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Critical+Reviews+in+Microbiology&rft.issn=1040841X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Reviews ER - TY - JOUR T1 - Radioprotective effect of hydroxyphenylethanolamines phenolic hydroxyl esters AN - 17230853; 4511161 AB - Experiments are carried out on 3000 mice, irradiated in dose 8 Gy (LD sub(97/30)). A number of phenolic hydroxyl esters of phenylephrine, norphenylephrine and epinephrine has the high RPE (70-100%) within 1 h before irradiation. 3-esters of 3-hydroxyphenylethanolamines are active in small doses (19-50 mu mol/kg) and protect per os too. RPE of 3-benzoylphenylephrine realizes via alpha sub(1)-adrenoreceptors. JF - Radiatsionnaia Biologiia, Radioekologii AU - Kulinsky, VI AU - Yashunsky, V G AU - Klimova, AD AU - Alpatova, T V AU - Kovtun, VY AD - Irkutsk State Medical University, NPS "Pharmzashchita", Himki, Russia Y1 - 1998 PY - 1998 DA - 1998 SP - 55 EP - 61 VL - 38 IS - 1 SN - 0869-8031, 0869-8031 KW - 3-hydroxyphenylethanolamine KW - epinephrine KW - mice KW - norfenefrine KW - phenolic hydroxyl esters KW - phenylephrine KW - Toxicology Abstracts KW - Radiation KW - Radioprotection KW - Radioprotective agents KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17230853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiatsionnaia+Biologiia%2C+Radioekologii&rft.atitle=Radioprotective+effect+of+hydroxyphenylethanolamines+phenolic+hydroxyl+esters&rft.au=Kulinsky%2C+VI%3BYashunsky%2C+V+G%3BKlimova%2C+AD%3BAlpatova%2C+T+V%3BKovtun%2C+VY&rft.aulast=Kulinsky&rft.aufirst=VI&rft.date=1998-01-01&rft.volume=38&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Radiatsionnaia+Biologiia%2C+Radioekologii&rft.issn=08698031&rft_id=info:doi/ LA - Russian DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Radiation; Radioprotective agents; Radioprotection ER - TY - JOUR T1 - Screening Software for an Innovative In Situ Bioremediation Technology AN - 16560020; 4399705 AB - Innovative in situ treatment technologies show promise as efficient methods for remediating the nation's waste sites. Unfortunately, due to various barriers, some innovative technologies that have been demonstrated at full scale are never transferred for commercial application. The National Research Council (NRC) has recently presented recommendations on how to overcome these barriers. User-friendly screening software, which specifically addresses each of the NRC recommendations, is presented for use by site managers to determine the appropriateness of an innovative remediation technology, in situ aerobic cometabolic bioremediation, to clean up a contaminated site with specified hydrogeologic and contaminant characteristics. The software estimates the performance and cost of the technology at the site. Software, such as the one presented, can be used to aid in the transfer and implementation of innovative remediation technologies. JF - Bioremediation Journal AU - Mandalas, G C AU - Christ, JA AU - Goltz, M N AD - Department of Engineering and Environmental Management, Air Force Institute of Technology, Wright-Patterson Air Force Base, OH 45433-7765, USA Y1 - 1998 PY - 1998 DA - 1998 SP - 7 EP - 15 VL - 2 IS - 1 SN - 1088-9868, 1088-9868 KW - computer programs KW - software KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts; Pollution Abstracts KW - Bioremediation KW - Pollution clean-up KW - Computer programs KW - Waste disposal sites KW - Computer applications KW - Environmental restoration KW - Technology KW - P 9000:ENVIRONMENTAL ACTION KW - W2 32080:Bioinformatics and computer applications KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16560020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioremediation+Journal&rft.atitle=Screening+Software+for+an+Innovative+In+Situ+Bioremediation+Technology&rft.au=Mandalas%2C+G+C%3BChrist%2C+JA%3BGoltz%2C+M+N&rft.aulast=Mandalas&rft.aufirst=G&rft.date=1998-01-01&rft.volume=2&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Bioremediation+Journal&rft.issn=10889868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Environmental restoration; Bioremediation; Waste disposal sites; Pollution clean-up; Computer applications; Technology; Computer programs ER - TY - JOUR T1 - Metabolic inhibition by transition metal ions in a slow-growing, toluene-enriched microbial population AN - 13666772; S199953073 AB - The influence of common, soluble transition metal cations on the metabolic rate of a microbial population was studied. A toluene substrate was used since it was a representative hydrocarbon pollutant and because its aerobic degradation was mediated by a non-specific dioxygenase enzyme system. Metabolic inhibition was measured as the ratio of oxygen consumption of treated samples relative to that of untreated samples. For the treated samples, the respiration rates decreased within 30 seconds of exposure and did not recover within the 80 minute observation period. Toxicity increased with metal-phosphate binding affinities in the phospholipid bilayer membrane of the cells. Results were in agreement with modelled predictions which postulated that metabolic inhibition was proportional to cell membrane damage inherent with transition metal ion chemisorption at phosphatic cell membrane sites. There was evidence that membrane damage was irreversible. JF - Environmental Toxicology & Water Quality AU - Burggraf, L W AU - Hansen, S D AU - Bleckmann, CA AD - Air Force Institute of Technology, WPAFB, Ohio Y1 - 1998 PY - 1998 DA - 1998 SP - 249 EP - 261 VL - 13 IS - 3 KW - Enzymes (see also individual groups below) KW - Modelling (-general-) KW - Reduction KW - Transition metal KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13666772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+%26+Water+Quality&rft.atitle=Metabolic+inhibition+by+transition+metal+ions+in+a+slow-growing%2C+toluene-enriched+microbial+population&rft.au=Burggraf%2C+L+W%3BHansen%2C+S+D%3BBleckmann%2C+CA&rft.aulast=Burggraf&rft.aufirst=L&rft.date=1998-01-01&rft.volume=13&rft.issue=3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+%26+Water+Quality&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Prenatal exposure to nicotine: effects on prepulse inhibition and central nicotinic receptors. AN - 79464613; 9408185 AB - The present experiment examined effects of prenatal nicotine exposure (6 mg/kg/day via osmotic minipump) throughout gestation on prepulse inhibition of the acoustic startle response (PPI) and on the density of nicotinic acetylcholine receptors (nAchRs) in the brains of 5-week-old Sprague-Dawley rats. A total of 117 male and 103 female offspring were used. Prenatal nicotine reduced subsequent percent PPI to a 98 dB stimulus in female but not in male offspring. There was an inverse correlation between the percent of PPI and nAchR density in the cortex of male rats and the striatum of female rats. JF - Pharmacology, biochemistry, and behavior AU - Popke, E J AU - Tizabi, Y AU - Rahman, M A AU - Nespor, S M AU - Grunberg, N E AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 1997/12// PY - 1997 DA - December 1997 SP - 843 EP - 849 VL - 58 IS - 4 SN - 0091-3057, 0091-3057 KW - Nicotinic Agonists KW - 0 KW - Receptors, Cholinergic KW - Receptors, Nicotinic KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Rats KW - Animals KW - Neostriatum -- metabolism KW - Receptors, Cholinergic -- drug effects KW - Sex Characteristics KW - Brain Chemistry -- drug effects KW - Neostriatum -- drug effects KW - Acoustic Stimulation KW - Receptors, Cholinergic -- metabolism KW - Male KW - Female KW - Pregnancy KW - Nicotinic Agonists -- toxicity KW - Reflex, Startle -- drug effects KW - Nicotine -- toxicity KW - Receptors, Nicotinic -- metabolism KW - Nicotine -- metabolism KW - Receptors, Nicotinic -- drug effects KW - Nicotinic Agonists -- metabolism KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79464613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Prenatal+exposure+to+nicotine%3A+effects+on+prepulse+inhibition+and+central+nicotinic+receptors.&rft.au=Popke%2C+E+J%3BTizabi%2C+Y%3BRahman%2C+M+A%3BNespor%2C+S+M%3BGrunberg%2C+N+E&rft.aulast=Popke&rft.aufirst=E&rft.date=1997-12-01&rft.volume=58&rft.issue=4&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-30 N1 - Date created - 1998-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Computer keyboard force and upper extremity symptoms AN - 16339182; 4298754 AB - This case-control study assessed whether office workers who report more severe levels of musculoskeletal symptoms of the upper extremities demonstrate higher levels of keyforce in comparison to controls with less severe symptoms. Office workers reporting working on computer keyboards for four hours per day were classified as cases or controls based upon a median split on a Composite Symptom Severity score (cases = 23, controls = 25). Keyboard force and keying rate were measured during a 15-minute keyboarding task. Measures of task-related discomfort, muscular fatigue, pain, upper extremity symptoms, psychological distress and force were collected at baseline, post-keyboard task, and recovery. Ratings of perceived effort and task credibility were also obtained. Measures of work demands, perceived job stress, and upper extremity strength and flexibility were also collected. The results indicated group equivalence on reported work demands and upper extremity strength. Cases were more likely to receive a medical diagnosis of upper extremity cumulative trauma disorder, awaken from sleep due to symptoms, report higher levels of pain during work, experience greater impact of pain on function, and report higher workload pressure and lower support. Cases generated significantly higher keyboarding forces than controls, although both groups produced forces well above that required to operate the keyboard (4-5 times activation force). Cases reported higher levels of upper extremity symptoms and discomfort than controls, and these measures were highest after the keyboarding task for both groups. No significant correlation between keyforce and key rate was observed in either group. Results suggest that generation of excessive force while working on a computer keyboard may contribute to the severity of upper extremity symptoms. Clinically, the findings suggest that evaluating how an individual worker performs keyboarding tasks, or his or her workstyle, may be helpful in the management of these symptoms and disorders. JF - Journal of Occupational and Environmental Medicine AU - Feuerstein, M AU - Armstrong, T AU - Hickey, P AU - Lincoln, A AD - Uniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA Y1 - 1997/12// PY - 1997 DA - Dec 1997 SP - 1144 EP - 1153 VL - 39 IS - 12 SN - 1076-2752, 1076-2752 KW - ergonomics KW - fatigue KW - keyboards KW - man-machine interactions KW - occupational health KW - Health & Safety Science Abstracts KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16339182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Computer+keyboard+force+and+upper+extremity+symptoms&rft.au=Feuerstein%2C+M%3BArmstrong%2C+T%3BHickey%2C+P%3BLincoln%2C+A&rft.aulast=Feuerstein&rft.aufirst=M&rft.date=1997-12-01&rft.volume=39&rft.issue=12&rft.spage=1144&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Activation of divalent cation influx into S. cerevisiae cells by hypotonic downshift. AN - 79421300; 9351893 AB - Subjecting Saccharomyces cerevisiae cells to a hypotonic downshift by transferring cells form YPD medium containing 0.8 M sorbitol to YPD medium without sorbitol induces a transient rapid influx of Ca2+ and other divalent cations into the cell. For cells grown in YPD at 37 degrees C, this hypotonic downshift increases Ca2+ accumulation 6.7-fold. Hypotonic downshift-induced Ca2+ accumulation and steady-state Ca2+ accumulation in isotonic YPD medium are differentially affected by dodecylamine and Mg2+. The Ca(2+)-influx pathway responsible for hypotonic-induced Ca2+ influx may account for about 10-35% of Ca2+ accumulation by cells growing in YPD. Ca2+ influx is not required for cells to survive a hypotonic downshift. Hypotonic downshift greatly reduces the ability of S. cerevisiae cells to survive a 5-min exposure to 10 mM Cd2+ suggesting that mutants resistant to acute Cd2+ exposure may help identify genes required for hypotonic downshift-induced divalent cation influx. JF - The Journal of membrane biology AU - Beeler, T AU - Gable, K AU - Dunn, T AD - Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1997/11/01/ PY - 1997 DA - 1997 Nov 01 SP - 77 EP - 83 VL - 160 IS - 1 SN - 0022-2631, 0022-2631 KW - Amines KW - 0 KW - Cations, Divalent KW - Hypotonic Solutions KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Amines -- pharmacology KW - Calcium -- metabolism KW - Calcium -- toxicity KW - Saccharomyces cerevisiae -- metabolism KW - Calcium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79421300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+membrane+biology&rft.atitle=Activation+of+divalent+cation+influx+into+S.+cerevisiae+cells+by+hypotonic+downshift.&rft.au=Beeler%2C+T%3BGable%2C+K%3BDunn%2C+T&rft.aulast=Beeler&rft.aufirst=T&rft.date=1997-11-01&rft.volume=160&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+membrane+biology&rft.issn=00222631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-02-19 N1 - Date created - 1998-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nitrogen dynamics of two elevation catchments during spring snowmelt 1966; a comparison of naturally acidified Snake River and non-acidified Deer Creek, Rocky Mountains, Colorado AN - 762682050; 2010-091064 JF - Eos, Transactions, American Geophysical Union AU - Heuer, Kristi AU - Tonnessen, Kathy AU - Brooks, Paul AU - Anonymous Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 195 EP - 196 PB - American Geophysical Union, Washington, DC VL - 78 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - solute transport KW - North America KW - Deer Creek KW - surface water KW - nitrogen KW - geochemical cycle KW - spatial distribution KW - transport KW - time factor KW - snow KW - drainage basins KW - Snake River KW - Colorado KW - Rocky Mountains KW - pH KW - meltwater KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762682050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Nitrogen+dynamics+of+two+elevation+catchments+during+spring+snowmelt+1966%3B+a+comparison+of+naturally+acidified+Snake+River+and+non-acidified+Deer+Creek%2C+Rocky+Mountains%2C+Colorado&rft.au=Heuer%2C+Kristi%3BTonnessen%2C+Kathy%3BBrooks%2C+Paul%3BAnonymous&rft.aulast=Heuer&rft.aufirst=Kristi&rft.date=1997-11-01&rft.volume=78&rft.issue=46%2C+Suppl.&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1997 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Colorado; Deer Creek; drainage basins; geochemical cycle; meltwater; nitrogen; North America; pH; Rocky Mountains; Snake River; snow; solute transport; spatial distribution; surface water; time factor; transport; United States ER - TY - JOUR T1 - SandyDuck perspective AN - 50066923; 2010-024915 JF - Eos, Transactions, American Geophysical Union AU - Thornton, Edward B AU - Anonymous Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 1 PB - American Geophysical Union, Washington, DC VL - 78 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - models KW - marine sediments KW - experimental studies KW - swash zone KW - sediment transport KW - shoaling KW - SandyDuck KW - ocean waves KW - grain size KW - sediments KW - nearshore environment KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50066923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=SandyDuck+perspective&rft.au=Thornton%2C+Edward+B%3BAnonymous&rft.aulast=Thornton&rft.aufirst=Edward&rft.date=1997-11-01&rft.volume=78&rft.issue=46%2C+Suppl.&rft.spage=F332&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1997 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - experimental studies; grain size; marine sediments; models; nearshore environment; ocean waves; SandyDuck; sediment transport; sediments; shoaling; swash zone ER - TY - JOUR T1 - Random wave transformation and sediment transport across barred and terraced sand beaches AN - 50065832; 2010-024973 JF - Eos, Transactions, American Geophysical Union AU - Orzech, Mark D AU - Kobayashi, Nobuhisa AU - Anonymous Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 1 PB - American Geophysical Union, Washington, DC VL - 78 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - currents KW - sand KW - breaking waves KW - time series analysis KW - sediment transport KW - clastic sediments KW - statistical analysis KW - standard deviation KW - bars KW - longshore currents KW - terraces KW - equilibrium KW - ocean currents KW - variations KW - beaches KW - ocean waves KW - sediments KW - beach profiles KW - field studies KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50065832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Random+wave+transformation+and+sediment+transport+across+barred+and+terraced+sand+beaches&rft.au=Orzech%2C+Mark+D%3BKobayashi%2C+Nobuhisa%3BAnonymous&rft.aulast=Orzech&rft.aufirst=Mark&rft.date=1997-11-01&rft.volume=78&rft.issue=46%2C+Suppl.&rft.spage=F342&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1997 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - bars; beach profiles; beaches; breaking waves; clastic sediments; currents; equilibrium; field studies; longshore currents; ocean currents; ocean waves; sand; sediment transport; sediments; standard deviation; statistical analysis; terraces; time series analysis; variations ER - TY - JOUR T1 - Toward the development of strategies to prevent ischemic neuronal injury. In vitro studies. AN - 79418989; 9369988 AB - Cerebellar granule cells in culture, which are extremely vulnerable to excitotoxin glutamate or N-methyl-D-aspartate (NMDA), were used to study mechanisms of neuronal cell death and protection. Paradoxically, pretreatment of these cells with subtoxic concentrations of NMDA markedly blocked the neurotoxicity resulting from subsequent exposure to glutamate or NMDA. The NMDA-mediated neuroprotection can be antagonized by pretreatment of these cells with protein synthesis inhibitors, suggesting an involvement of protein(s) with neuroprotectant properties, most likely neurotrophic factors. Because basic fibroblast growth factor (BFGF) is well known to prevent neuronal cell death following mechanical or chemical injury, we have tested whether NMDA increases the synthesis of bFGF in cerebellar granule cells. NMDA elicited a rapid and time-dependent increase in bFGF mRNA, suggesting that availability of this trophic factor may play a role in the NMDA-mediated neuroprotection. JF - Annals of the New York Academy of Sciences AU - Marini, A M AU - Spiga, G AU - Mocchetti, I AD - Department of Neurology, Walter Reed Army Medical Center, Washington, DC, USA. amarini@usuhs.mil Y1 - 1997/10/15/ PY - 1997 DA - 1997 Oct 15 SP - 209 EP - 219 VL - 825 SN - 0077-8923, 0077-8923 KW - Neuroprotective Agents KW - 0 KW - Neurotoxins KW - Receptors, N-Methyl-D-Aspartate KW - Fibroblast Growth Factor 2 KW - 103107-01-3 KW - Glutamic Acid KW - 3KX376GY7L KW - N-Methylaspartate KW - 6384-92-5 KW - Index Medicus KW - Fibroblast Growth Factor 2 -- biosynthesis KW - Animals KW - Transcription, Genetic -- drug effects KW - Apoptosis KW - Receptors, N-Methyl-D-Aspartate -- drug effects KW - Cell Death KW - Glutamic Acid -- toxicity KW - Cerebellum -- cytology KW - Brain Ischemia -- pathology KW - N-Methylaspartate -- pharmacology KW - Brain Ischemia -- prevention & control KW - Neurons -- drug effects KW - Cerebellum -- drug effects KW - Neurons -- cytology KW - Neurotoxins -- pharmacology KW - Cerebellum -- pathology KW - Neurotoxins -- toxicity KW - Neuroprotective Agents -- pharmacology KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79418989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Toward+the+development+of+strategies+to+prevent+ischemic+neuronal+injury.+In+vitro+studies.&rft.au=Marini%2C+A+M%3BSpiga%2C+G%3BMocchetti%2C+I&rft.aulast=Marini&rft.aufirst=A&rft.date=1997-10-15&rft.volume=825&rft.issue=&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-12-09 N1 - Date created - 1997-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hazardous drugs. AN - 79376452; 9353816 AB - Engineering controls and personal protective equipment are crucial for health care professionals working in situations where cytotoxic agents, pharmaceuticals such as ribavirin and pentamidine, and other potentially hazardous drugs are present. Plans for exposure control, spill clean-up, and medical surveillance must be instituted to protect the employee. JF - Occupational medicine (Philadelphia, Pa.) AU - Black, L A AU - Presson, A C AD - Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, MD, USA. PY - 1997 SP - 669 EP - 685 VL - 12 IS - 4 SN - 0885-114X, 0885-114X KW - Hazardous Substances KW - 0 KW - Index Medicus KW - United States KW - Engineering KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - United States Occupational Safety and Health Administration KW - Pharmacy Service, Hospital KW - Protective Devices KW - Population Surveillance KW - Occupational Exposure -- prevention & control KW - Hazardous Substances -- adverse effects KW - Health Personnel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79376452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.atitle=Hazardous+drugs.&rft.au=Black%2C+L+A%3BPresson%2C+A+C&rft.aulast=Black&rft.aufirst=L&rft.date=1997-10-01&rft.volume=12&rft.issue=4&rft.spage=669&rft.isbn=&rft.btitle=&rft.title=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.issn=0885114X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-12-09 N1 - Date created - 1997-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Politics of Legal Reform in Palestine AN - 61492265; 9902243 AB - After briefly reviewing the legal systems in the West Bank & Gaza from 1948 until the Oslo agreements, major obstacles to creating a viable legal system in Palestine are identified as the difficulties in unifying two distinct legal systems -- the continental, Jordanian system in the West Bank, & the Anglo Saxon, common law system in Gaza -- & the blurred lines of authority. It is argued that the Palestinian legal sector, where decision making has been characterized by uncertainty, diktat, & personalism, can be seen as a microcosm of Palestinian Authority politics. In both the legal sector & in general, this authority has created a "politics of antithesis" to consolidate its own power. Adapted from the source document. JF - Journal of Palestine Studies AU - Robinson, Glenn E AD - US Naval Postgraduate School, Monterey CA 93943 Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 51 EP - 60 VL - 27 SN - 0377-919X, 0377-919X KW - Political Factors KW - Law KW - Palestine KW - Political Power KW - Legal System KW - article KW - 1636: social control; sociology of law UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61492265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Palestine+Studies&rft.atitle=The+Politics+of+Legal+Reform+in+Palestine&rft.au=Robinson%2C+Glenn+E&rft.aulast=Robinson&rft.aufirst=Glenn&rft.date=1997-10-01&rft.volume=27&rft.issue=&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+Palestine+Studies&rft.issn=0377919X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JLPSB2 N1 - SubjectsTermNotLitGenreText - Law; Legal System; Palestine; Political Factors; Political Power ER - TY - JOUR T1 - Approaches to Automating the Dereplication of Bioactive Natural Products-The Key Step in High Throughput Screening of Bioactive Materials From Natural Sources AN - 21212389; 11616952 AB - The rapid identification of the bioactive component(s) of natural product mixtures in high throughput screening programs has become a critical factor to ensure that this source of diverse chemotypes can compete effectively with chemical compound libraries and combinatorial synthetic efforts. The effective use of automated procedures and databases in the isolation, identification and biological profiling of bioactive compounds will be described. In addition, the potential of new technologies to enhance this process will be discussed as well as the possible reintroduction of TLC as a parallel dereplication method. JF - Journal of Biomolecular Screening AU - Hook, Derek J AU - Pack, Edward J AU - Yacobucci, Joseph J AU - Guss, Jeffrey AD - NPS Pharmaceuticals, 420 Chipeta Way, Salt Lake City, UT 84108 Y1 - 1997/10// PY - 1997 DA - Oct 1997 SP - 145 EP - 152 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 2 IS - 3 SN - 1087-0571, 1087-0571 KW - Biotechnology and Bioengineering Abstracts KW - Reintroduction KW - Databases KW - Computer programs KW - natural products KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21212389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Approaches+to+Automating+the+Dereplication+of+Bioactive+Natural+Products-The+Key+Step+in+High+Throughput+Screening+of+Bioactive+Materials+From+Natural+Sources&rft.au=Hook%2C+Derek+J%3BPack%2C+Edward+J%3BYacobucci%2C+Joseph+J%3BGuss%2C+Jeffrey&rft.aulast=Hook&rft.aufirst=Derek&rft.date=1997-10-01&rft.volume=2&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F108705719700200304 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Reintroduction; Computer programs; Databases; natural products DO - http://dx.doi.org/10.1177/108705719700200304 ER - TY - JOUR T1 - Effect of inflammatory and anti-inflammatory stimuli on acyloxyacyl hydrolase gene expression and enzymatic activity in murine macrophages AN - 16277883; 4290002 AB - Acyloxyacyl hydrolase (AOAH) is an enzyme found in macrophages and neutrophils that specifically cleaves the acyloxyacyl moieties of lipopolysaccharide (LPS), thus rendering it non-toxic for human cells. In the present study, we demonstrate that LPS augments AOAH mRNA expression (10-20-fold) in murine macrophages. Following LPS treatment (100 ng/m]), AOAH mRNA was induced by 2 h, peaked at 6 h, and was sustained over 72 h. Optimal induction of AOAH mRNA was observed with as little as 0.1 ng/ml LPS. LPS also induced a concomitant increase in AOAH enzymatic activity in cytosolic extracts from murine macrophages and the ability of macrophages to deacylate LPS was not diminished in endotoxin-tolerized macrophages. LPS-stimulated AOAH mRNA expression was cycloheximide sensitive, indicating that de novo protein synthesis is required for AOAH mRNA production. Moreover, AOAH mRNA expression was also induced by IFN- gamma . LPS-stimulated mRNA expression was not suppressed by either dexamethasone or IL-10. Finally, intraperitoneal challenge of mice with 25 mu g of LPS resulted in increases in AOAH mRNA in both the lung ( similar to 3-fold) and in the liver ( similar to 6-fold). A possible role for LPS-inducible AOAH in the elimination of LPS is discussed. JF - Journal of Endotoxin Research AU - Cody, MJ AU - Salkowski, CA AU - Henricson, B E AU - Detore, G R AU - Munford, R S AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA Y1 - 1997/10// PY - 1997 DA - Oct 1997 SP - 371 EP - 379 VL - 4 IS - 5 SN - 0968-0519, 0968-0519 KW - gamma -Interferon KW - gamma -interferon KW - acyloxyacyl hydrolase KW - endotoxins KW - gene expression KW - immune response KW - lipopolysaccharides KW - macrophages KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - X 24171:Microbial KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16277883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=Effect+of+inflammatory+and+anti-inflammatory+stimuli+on+acyloxyacyl+hydrolase+gene+expression+and+enzymatic+activity+in+murine+macrophages&rft.au=Cody%2C+MJ%3BSalkowski%2C+CA%3BHenricson%2C+B+E%3BDetore%2C+G+R%3BMunford%2C+R+S%3BVogel%2C+S+N&rft.aulast=Cody&rft.aufirst=MJ&rft.date=1997-10-01&rft.volume=4&rft.issue=5&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Short-term effects of salinity reduction and drainage on salt-marsh biogeochemical cycling andSpartina (cordgrass production AN - 968174511; 16466586 AB - To assess the biogeochemical effects of tidal restrictions on salt-marsh sulfur cycling and plant growth, cores of short-formSpartina alterniflora peat were desalinated and kept either waterlogged or drained in greenhouse microcosms. Changes in netSpartina production, and porewater and solid phase chemistry of treated cores were compared to natural conditions in the field collection site over a 21-mo period. Net production among treatments increased significantly in drained and waterlogged peat compared to field conditions during the first growing season. Constantly high sulfide in waterlogged cores accompanied reduced plant growth. Aeration invigorated growth in draimed cores but led to oxidization of sulfide minerals and to lowered pH. During the second growing season, growth declined in the drained treatment, probably because of acidification and decreased dissolved inorganic nitrogen. Results are pertinent to the success of current wetland protection and restoration activities in the coastal zone. JF - Estuaries AU - Portnoy, J W AU - Valiela, I AD - Cape Cod National Seashore, United States Geological Survey, 99 Marconi Road, Wellfleet, 02667, Massachusetts, john_portnoy@nps.gov Y1 - 1997/09// PY - 1997 DA - Sep 1997 SP - 569 EP - 578 PB - Estuarine Research Federation, 490 Chippingwood Dr. Port Republic MD 20676-2140 United States VL - 20 IS - 3 SN - 0160-8347, 0160-8347 KW - Oceanic Abstracts; Ecology Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Sulfur KW - Sulphides KW - Growth KW - Cores KW - Salinity effects KW - Wetlands KW - Microcosms KW - Acidification KW - pH effects KW - Plant Growth KW - Biogeochemistry KW - Drainage KW - Sulfides KW - Estuaries KW - Brackish KW - Solids KW - Interstitial Water KW - Aeration KW - Estuarine chemistry KW - Greenhouses KW - Peat KW - Sulfide KW - Coastal zone KW - Salt marshes KW - Plant growth KW - Minerals KW - Nitrogen KW - Q5 08503:Characteristics, behavior and fate KW - Q1 08463:Habitat community studies KW - O 4090:Conservation and Environmental Protection KW - SW 1010:Saline water conversion KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968174511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuaries&rft.atitle=Short-term+effects+of+salinity+reduction+and+drainage+on+salt-marsh+biogeochemical+cycling+andSpartina+%28cordgrass+production&rft.au=Portnoy%2C+J+W%3BValiela%2C+I&rft.aulast=Portnoy&rft.aufirst=J&rft.date=1997-09-01&rft.volume=20&rft.issue=3&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Estuaries&rft.issn=01608347&rft_id=info:doi/10.2307%2F1352615 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Sulphides; Growth; Salt marshes; Biogeochemistry; Salinity effects; Wetlands; Plant growth; Estuarine chemistry; Peat; Sulfur; Drainage; Estuaries; Aeration; Greenhouses; Sulfide; Coastal zone; Acidification; Microcosms; pH effects; Minerals; Nitrogen; Plant Growth; Cores; Sulfides; Solids; Interstitial Water; Brackish DO - http://dx.doi.org/10.2307/1352615 ER - TY - JOUR T1 - Pleural macrophage recruitment and activation in asbestos-induced pleural injury. AN - 79467093; 9400734 AB - The pathogenesis of asbestos-induced pleural fibrosis is poorly understood. Moreover, there has been a long-standing controversy regarding the relative potential of different commercial types of asbestos to cause pleural disease. We postulated that inhaled asbestos fibers translocate to the pleural space where they stimulate the recruitment and activation of pleural macrophages. To test this hypothesis, and to determine whether there are differences between inhaled amphibole and serpentine asbestos, Fischer 344 rats were exposed by intermittent inhalation (6 hr/day for 5 days/week over 2 weeks) to either National Institute of Environmental Health Sciences (NIEHS) crocidolite (average concentration 7.55 mg/m3) or NIEHS chrysotile fibers (average concentration 8.51 mg/m3). Comparisons were made with sham-exposed rats. The rats were sacrificed at 1 and 6 weeks after the cessation of exposure. More pleural macrophages were recovered at 1 and 6 weeks after crocidolite and chrysotile exposure than after sham exposure. Small numbers of crocidolite fibers (approximately 1 per 4000 cells) were detected in the pleural cell pellet of one crocidolite-exposed rat by scanning electron microscopy. Pleural macrophage supernatants were assayed for production of nitric oxide (NO) (by the Griess reaction) and tumor necrosis factor alpha (TNF-alpha) (by an enzyme-linked immunosorbent assay method). Significantly greater amounts of NO as well as TNF-alpha were generated by pleural macrophages at 1 and 6 weeks after either crocidolite or chrysotile inhalation than after sham exposure. Conceivably, translocation of asbestos fibers to the pleural space may provide a stimulus for persistent pleural space inflammation, cytokine production, and the generation of toxic oxygen and nitrogen radicals. Enhanced cytokine secretion within the pleural space may in turn upregulate adhesion molecule expression and the synthesis of extracellular matrix constituents by pleural mesothelial cells. Thus, our findings may have significance for the development of asbestos-induced pleural injury. JF - Environmental health perspectives AU - Choe, N AU - Tanaka, S AU - Xia, W AU - Hemenway, D R AU - Roggli, V L AU - Kagan, E AD - Department of Pathology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, MD 20814-4799, USA. Y1 - 1997/09// PY - 1997 DA - September 1997 SP - 1257 EP - 1260 VL - 105 Suppl 5 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Tumor Necrosis Factor-alpha KW - Asbestos, Crocidolite KW - 12001-28-4 KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Cell Count KW - Cells, Cultured KW - Particle Size KW - Nitric Oxide -- metabolism KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Male KW - Microscopy, Electron, Scanning KW - Macrophage Activation -- drug effects KW - Pleura -- drug effects KW - Carcinogens -- toxicity KW - Macrophages -- physiology KW - Pleura -- pathology KW - Macrophages -- drug effects KW - Pleura -- cytology KW - Asbestos, Crocidolite -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79467093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Pleural+macrophage+recruitment+and+activation+in+asbestos-induced+pleural+injury.&rft.au=Choe%2C+N%3BTanaka%2C+S%3BXia%2C+W%3BHemenway%2C+D+R%3BRoggli%2C+V+L%3BKagan%2C+E&rft.aulast=Choe&rft.aufirst=N&rft.date=1997-09-01&rft.volume=105+Suppl+5&rft.issue=&rft.spage=1257&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-30 N1 - Date created - 1998-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am Ind Hyg Assoc J. 1982 Dec;43(12):874-9 [7158602] Am J Respir Cell Mol Biol. 1994 Mar;10(3):245-52 [8117443] Arch Environ Health. 1986 Sep-Oct;41(5):282-6 [3026258] J Toxicol Environ Health. 1988;24(1):41-66 [3373564] Am Rev Respir Dis. 1990 Oct;142(4):843-7 [2171386] Chest. 1991 Jan;99(1):191-8 [1984952] Am Rev Respir Dis. 1991 Feb;143(2):408-22 [1990961] J Biol Chem. 1991 Mar 5;266(7):4244-50 [1847917] Br J Ind Med. 1991 Nov;48(11):762-70 [1659443] J Clin Invest. 1992 Apr;89(4):1257-67 [1556187] Ann N Y Acad Sci. 1991 Dec 31;643:27-52 [1809139] Carcinogenesis. 1992 Apr;13(4):637-42 [1315628] Am J Physiol. 1993 Oct;265(4 Pt 1):L382-8 [8238372] Am J Respir Cell Mol Biol. 1994 Feb;10(2):167-76 [8110473] Chest. 1994 Mar;105(3 Suppl):79S-84S [8131620] Am J Respir Cell Mol Biol. 1994 Dec;11(6):707-15 [7524571] Am J Respir Cell Mol Biol. 1995 Jun;12(6):581-8 [7766422] Clin Immunol Immunopathol. 1995 Jun;75(3):231-8 [7768040] Int J Exp Pathol. 1995 Jun;76(3):163-70 [7547426] Mod Pathol. 1995 Aug;8(6):614-21 [8532693] Am J Respir Crit Care Med. 1996 Jan;153(1):444-9 [8542156] Arch Biochem Biophys. 1996 Feb 1;326(1):152-7 [8579364] Environ Health Perspect. 1983 Sep;51:41-7 [6315380] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tachykinergic neurotransmission is enhanced in small intestinal circular muscle in a rabbit model of inflammation. AN - 79313805; 9316849 AB - Previous electrophysiological studies have shown that tachykinin-mediated excitatory junction potentials are enhanced in a ricin model of inflammatory bowel disease. The present study extends these findings by investigating the contractile response to stimulation of noncholinergic nerves and tachykinin agonists. According to rank order potencies, the rabbit ileal circular muscle was neurokinin (NK)1 preferring, and the response to these agonists was down-regulated by acetylcholine and up-regulated by nitric oxide. In ricin-treated tissue, cholinergic and nitridergic modulation was lost; in the presence of atropine and N-nitro-L-arginine methyl ester, or tetrodotoxin, the response to NK1 and NK2 agonists was enhanced. The noncholinergic response to nerve stimulation was predominantly mediated by NK1 receptors, and the enhanced response of ricin-treated tissue to NK1 agonists probably contributes to the increased response to electrical field stimulation observed under these conditions. Increased tachykinin response and loss of control of this response by acetylcholine and nitric oxide are likely to have profound effects on intestinal motility and could contribute to some of the symptomology of inflammatory bowel disease. JF - The Journal of pharmacology and experimental therapeutics AU - Goldhill, J M AU - Shea-Donohue, T AU - Ali, N AU - Piñeiro-Carrero, V M AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 1997/09// PY - 1997 DA - September 1997 SP - 1373 EP - 1378 VL - 282 IS - 3 SN - 0022-3565, 0022-3565 KW - Tachykinins KW - 0 KW - Ricin KW - 9009-86-3 KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Muscle Contraction -- drug effects KW - In Vitro Techniques KW - Rabbits KW - Acetylcholine -- pharmacology KW - Ricin -- pharmacology KW - Male KW - Ileitis -- physiopathology KW - Tachykinins -- pharmacology KW - Synaptic Transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79313805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Tachykinergic+neurotransmission+is+enhanced+in+small+intestinal+circular+muscle+in+a+rabbit+model+of+inflammation.&rft.au=Goldhill%2C+J+M%3BShea-Donohue%2C+T%3BAli%2C+N%3BPi%C3%B1eiro-Carrero%2C+V+M&rft.aulast=Goldhill&rft.aufirst=J&rft.date=1997-09-01&rft.volume=282&rft.issue=3&rft.spage=1373&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-17 N1 - Date created - 1997-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hyperactivity and hypoactivity in a rat model of Huntington's disease: the systemic 3-nitropropionic acid model. AN - 79411691; 9385062 AB - The present study proposes the use of systemic 3-nitropropionic acid (3-NP) treatment in rats as a model of Huntington's disease (HD). The systemic 3-NP model involves chronic injection of low dose intraperitoneal (i.p.) injections of 3-NP to rats once every 4 days over a period of time. Evidence from our experimental studies suggests that manipulating the number of injections can result in either increased nocturnal spontaneous locomotor activity (hyperactivity) or nocturnal akinesia (hypoactivity) [1]. For example, two injections of 3-NP (using the treatment of one injection every 4 days) result in hyperactivity, while four injections or more of 3-NP lead to hypoactivity [1]. The locomotor activity is recorded by Digiscan locomotor activity monitors [11]. The observation of these two types of locomotor activity is unique since no excitotoxin model has replicated a two-stage progression of a HD-like behavioral alteration. Most studies using excitotoxins like quinolinic acid (QA) and kainic acid (KA) have only reproduced the hyperactivity stage [4,5,7]. With the systemic 3-NP model, investigations into at least two stages of the disease are made possible. This allows for better assessment of intervention strategies such as neural transplants across different stages of the disease. The systemic 3-NP rat model is believed to be an improved animal model of HD. JF - Brain research. Brain research protocols AU - Borlongan, C V AU - Koutouzis, T K AU - Freeman, T B AU - Hauser, R A AU - Cahill, D W AU - Sanberg, P R AD - Department of Surgery, University of South Florida College of Medicine, Tampa 33612, USA. cborlong@usuhs.mil Y1 - 1997/08// PY - 1997 DA - August 1997 SP - 253 EP - 257 VL - 1 IS - 3 SN - 1385-299X, 1385-299X KW - Nitro Compounds KW - 0 KW - Propionates KW - 3-nitropropionic acid KW - QY4L0FOX0D KW - Index Medicus KW - Rats KW - Injections, Intraperitoneal KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Drug Administration Schedule KW - Male KW - Huntington Disease -- physiopathology KW - Huntington Disease -- chemically induced KW - Propionates -- pharmacology KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Propionates -- administration & dosage KW - Huntington Disease -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79411691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research.+Brain+research+protocols&rft.atitle=Hyperactivity+and+hypoactivity+in+a+rat+model+of+Huntington%27s+disease%3A+the+systemic+3-nitropropionic+acid+model.&rft.au=Borlongan%2C+C+V%3BKoutouzis%2C+T+K%3BFreeman%2C+T+B%3BHauser%2C+R+A%3BCahill%2C+D+W%3BSanberg%2C+P+R&rft.aulast=Borlongan&rft.aufirst=C&rft.date=1997-08-01&rft.volume=1&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Brain+research.+Brain+research+protocols&rft.issn=1385299X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-12-16 N1 - Date created - 1997-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of sensory afferents in the myoelectric response to acute enteric inflammation in the rabbit. AN - 79260415; 9277424 AB - The role of sensory afferents in inflammation-induced alterations in myoelectric activity in vivo was investigated in the rabbit small intestine. Isolated ileal loops were implanted with serosal electrodes and exposed to ricin or vehicle after pretreatment with 125 mg/kg of subcutaneous (125 mg over 3 days) or intraluminal (640 microM) capsaicin. After 5 h of myoelectric recording, the loops were prepared for histology and for ex vivo generation of eicosanoids. Capsaicin exacerbated mucosal damage after exposure to ricin but did not alter neutrophil infiltration. Subcutaneous capsaicin alone elevated slow-wave frequency and spike events and transiently suppressed the myoelectric response to ricin. In contrast, intraluminal capsaicin alone did not alter myoelectric activity but produced a sustained inhibition of the response to ricin. Eicosanoid production was unchanged by capsaicin alone. Intraluminal capsaicin blocked increases in leukotriene C4 and prostaglandin E2 during inflammation, an effect that paralleled its inhibition of myoelectric activity. Thus the contribution of sensory afferents to altered motility during acute ileitis involves the release of mucosal inflammatory mediators that influence neural control of smooth muscle. JF - The American journal of physiology AU - Shea-Donohue, T AU - Goldhill, J M AU - Montcalm-Mazzilli, E AU - Colleton, C AU - Piñeiro-Carrero, V M AU - Sjogren, R W AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1997/08// PY - 1997 DA - August 1997 SP - G447 EP - G455 VL - 273 IS - 2 Pt 1 SN - 0002-9513, 0002-9513 KW - Eicosanoids KW - 0 KW - Ricin KW - 9009-86-3 KW - Capsaicin KW - S07O44R1ZM KW - Index Medicus KW - Acute Disease KW - Animals KW - In Vitro Techniques KW - Rabbits KW - Eicosanoids -- biosynthesis KW - Electrophysiology KW - Male KW - Capsaicin -- pharmacology KW - Muscle, Smooth -- pathology KW - Ileitis -- physiopathology KW - Ileitis -- chemically induced KW - Ileum -- physiopathology KW - Ileitis -- metabolism KW - Ileum -- metabolism KW - Ileum -- pathology KW - Neurons, Afferent -- physiology KW - Muscle, Smooth -- physiopathology KW - Muscle, Smooth -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79260415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Role+of+sensory+afferents+in+the+myoelectric+response+to+acute+enteric+inflammation+in+the+rabbit.&rft.au=Shea-Donohue%2C+T%3BGoldhill%2C+J+M%3BMontcalm-Mazzilli%2C+E%3BColleton%2C+C%3BPi%C3%B1eiro-Carrero%2C+V+M%3BSjogren%2C+R+W&rft.aulast=Shea-Donohue&rft.aufirst=T&rft.date=1997-08-01&rft.volume=273&rft.issue=2+Pt+1&rft.spage=G447&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-09-24 N1 - Date created - 1997-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages. AN - 79155710; 9234781 AB - Monophosphoryl lipid A (MPL) is a nontoxic derivative of the lipid A region of lipopolysaccharide (LPS) that is being developed as both an adjuvant and prophylactic drug for septic shock. We compared the ability of LPS and MPL to induce interleukin-10 (IL-10), IL-12 p35, IL-12 p40, gamma interferon (IFN-gamma), glucocorticoid receptor (GR), IL-1 receptor antagonist (IL-1ra), and inducible nitric oxide synthase mRNA expression in murine peritoneal macrophages. These genes were chosen for their ability to positively or negatively regulate the host immune response and thus for their potential involvement in MPL-induced adjuvanticity or in its ability to protect against sepsis. LPS was a more potent inducer of IL-12 p35, IL-12 p40, and IFN-gamma mRNA, as well as of IL-12 protein, than MPL. In contrast, MPL induced higher levels of IL-10 mRNA than did LPS from 1 to 1,000 ng/ml. In general, MPL was not a more potent inducer of negative regulatory genes, since MPL and LPS induced similar levels of GR and IL-1ra mRNA. Addition of anti-IL-10 antibody to cultures increased the induction of MPL-induced IL-12 p35, IL-12 p40, and IFN-gamma mRNA, suggesting that the enhanced production of IL-10 by MPL-stimulated macrophages contributes to decreased production of mRNA for IL-12 (p35 and p40) and IFN-gamma. Conversely, the addition of exogenous IL-10 to LPS-treated macrophages reduced the mRNA expression of these cytokine genes. These studies suggest that enhanced production of IL-10 by MPL-stimulated macrophages may contribute to the reduced toxicity of MPL through its negative action on induction of cytokines shown to enhance endotoxicity. JF - Infection and immunity AU - Salkowski, C A AU - Detore, G R AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Services, University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1997/08// PY - 1997 DA - August 1997 SP - 3239 EP - 3247 VL - 65 IS - 8 SN - 0019-9567, 0019-9567 KW - Il1rn protein, mouse KW - 0 KW - Interleukin 1 Receptor Antagonist Protein KW - Lipid A KW - Lipopolysaccharides KW - RNA, Messenger KW - Receptors, Glucocorticoid KW - Sialoglycoproteins KW - Interleukin-10 KW - 130068-27-8 KW - Interleukin-12 KW - 187348-17-0 KW - Interferon-gamma KW - 82115-62-6 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - monophosphoryl lipid A KW - MWC0ET1L2P KW - Index Medicus KW - Animals KW - Sialoglycoproteins -- genetics KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Nitric Oxide Synthase -- genetics KW - RNA, Messenger -- analysis KW - Mice, Inbred C3H KW - Mice KW - Receptors, Glucocorticoid -- genetics KW - Interferon-gamma -- genetics KW - Lipopolysaccharides -- pharmacology KW - Interleukin-10 -- pharmacology KW - Interferon-gamma -- pharmacology KW - Interleukin-10 -- genetics KW - Gene Expression Regulation -- drug effects KW - Macrophages -- drug effects KW - Interleukin-12 -- genetics KW - Lipid A -- pharmacology KW - Lipid A -- analogs & derivatives KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79155710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Lipopolysaccharide+and+monophosphoryl+lipid+A+differentially+regulate+interleukin-12%2C+gamma+interferon%2C+and+interleukin-10+mRNA+production+in+murine+macrophages.&rft.au=Salkowski%2C+C+A%3BDetore%2C+G+R%3BVogel%2C+S+N&rft.aulast=Salkowski&rft.aufirst=C&rft.date=1997-08-01&rft.volume=65&rft.issue=8&rft.spage=3239&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-08-14 N1 - Date created - 1997-08-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1996 Feb 1;156(3):1196-206 [8557998] J Immunother Emphasis Tumor Immunol. 1994 Feb;15(2):129-33 [8136945] Infect Immun. 1996 Jun;64(6):2010-8 [8675301] J Immunol. 1997 Jan 15;158(2):905-12 [8993010] Biochemistry. 1967 Aug;6(8):2363-72 [4867999] Rev Infect Dis. 1984 Jul-Aug;6(4):439-43 [6474003] Science. 1985 Aug 30;229(4716):869-71 [3895437] Infect Immun. 1986 Mar;51(3):891-5 [3949385] Infect Immun. 1986 Apr;52(1):6-11 [3514464] Infect Immun. 1986 Jul;53(1):6-12 [3487507] EMBO J. 1986 Oct;5(10):2513-22 [3780669] Eur J Immunol. 1989 Feb;19(2):301-5 [2784766] J Clin Microbiol. 1989 Aug;27(8):1748-53 [2504774] J Exp Med. 1990 Jun 1;171(6):1853-69 [2112583] Infect Immun. 1990 Aug;58(8):2429-37 [1695201] J Immunol. 1990 Nov 1;145(9):2920-4 [2120341] J Exp Med. 1991 May 1;173(5):1177-82 [2022925] Eur J Immunol. 1991 Sep;21(9):1973-9 [1716205] J Immunol. 1991 Oct 1;147(7):2391-7 [1717559] J Exp Med. 1991 Nov 1;174(5):1209-20 [1940799] Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1890-3 [1371884] J Clin Invest. 1992 May;89(5):1551-7 [1533231] J Exp Med. 1992 Aug 1;176(2):485-94 [1380063] J Immunol. 1992 Sep 1;149(5):1666-70 [1506688] Infect Immun. 1992 Oct;60(10):4285-90 [1398939] J Immunol. 1992 Dec 15;149(12):4041-7 [1360996] J Exp Med. 1993 Feb 1;177(2):523-7 [8426121] J Exp Med. 1993 Feb 1;177(2):547-50 [8426124] Circ Shock. 1993 Mar;39(3):194-8 [8453743] Clin Microbiol Rev. 1993 Jan;6(1):57-68 [8457980] Infect Immun. 1993 Jun;61(6):2325-33 [8388859] J Immunol. 1993 Jul 15;151(2):916-21 [8335919] J Exp Med. 1993 Sep 1;178(3):1041-8 [8102388] J Exp Med. 1993 Nov 1;178(5):1473-81 [8228801] Reg Immunol. 1993 May-Aug;5(3-4):142-50 [7902123] Int Immunol. 1993 Nov;5(11):1383-92 [8260452] Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):271-5 [7506416] J Immunol. 1994 Jan 15;152(2):825-31 [7506736] J Lab Clin Med. 1994 Jan;123(1):89-93 [8288966] J Exp Med. 1994 May 1;179(5):1437-44 [8163930] J Exp Med. 1994 May 1;179(5):1551-61 [7909326] J Exp Med. 1994 May 1;179(5):1731-6 [8163951] J Exp Med. 1994 Sep 1;180(3):907-15 [7914909] Infect Immun. 1994 Oct;62(10):4244-9 [7927680] J Immunol. 1995 Jan 1;154(1):116-27 [7527811] Crit Care Med. 1995 Jan;23(1):9-17 [8001393] Infect Immun. 1995 Jan;63(1):168-74 [7806354] Prog Clin Biol Res. 1994;388:107-24 [7831353] Circ Shock. 1994 Jul;43(3):107-14 [7850930] Eur J Immunol. 1995 Mar;25(3):672-6 [7705395] J Immunol. 1995 Apr 15;154(8):4048-54 [7706743] J Exp Med. 1995 May 1;181(5):1887-92 [7722463] Infect Immun. 1995 May;63(5):1863-9 [7729896] Shock. 1994 Oct;2(4):271-4 [7757520] Cell. 1995 May 19;81(4):641-50 [7538909] J Immunol. 1995 Sep 15;155(6):3168-79 [7673730] Prog Clin Biol Res. 1995;392:567-79 [8524964] Pharm Biotechnol. 1995;6:495-524 [7551233] J Immunol. 1995 Nov 15;155(10):4890-8 [7594493] J Clin Invest. 1995 Nov;96(5):2339-47 [7593621] J Immunol. 1995 Dec 1;155(11):5337-42 [7594548] J Immunol. 1995 Dec 1;155(11):5397-401 [7594556] J Immunol. 1996 Feb 1;156(3):1207-12 [8557999] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DDT, global strategies, and a malaria control crisis in South America. AN - 79276351; 9284373 AB - Malaria is reemerging in endemic-disease countries of South America. We examined the rate of real growth in annual parasite indexes (API) by adjusting APIs for all years to the annual blood examination rate of 1965 for each country. The standardized APIs calculated for Brazil, Peru, Guyana, and for 18 other malaria-endemic countries of the Americas presented a consistent pattern of low rates up through the late 1970s, followed by geometric growth in malaria incidence in subsequent years. True growth in malaria incidence corresponds temporally with changes in global strategies for malaria control. Underlying the concordance of these events is a causal link between decreased spraying of homes with DDT and increased malaria; two regression models defining this link showed statistically significant negative relationships between APIs and house-spray rates. Separate analyses of data from 1993 to 1995 showed that countries that have recently discontinued their spray programs are reporting large increases in malaria incidence. Ecuador, which has increased use of DDT since 1993, is the only country reporting a large reduction (61%) in malaria rates since 1993. DDT use for malaria control and application of the Global Malaria Control Strategy to the Americas should be subjects of urgent national and international debate. We discuss the recent actions to ban DDT, the health costs of such a ban, perspectives on DDT use in agriculture versus malaria control, and costs versus benefits of DDT and alternative insecticides. JF - Emerging infectious diseases AU - Roberts, D R AU - Laughlin, L L AU - Hsheih, P AU - Legters, L J AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. droberts@usuhsb.usuhs.mil PY - 1997 SP - 295 EP - 302 VL - 3 IS - 3 SN - 1080-6040, 1080-6040 KW - Insecticides KW - 0 KW - DDT KW - CIW5S16655 KW - Index Medicus KW - Agriculture KW - Public Health KW - Humans KW - Cost-Benefit Analysis KW - South America -- epidemiology KW - Malaria -- prevention & control KW - Malaria -- epidemiology KW - DDT -- economics KW - Insecticides -- economics KW - DDT -- pharmacology KW - Insecticides -- pharmacology KW - Malaria -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79276351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+infectious+diseases&rft.atitle=DDT%2C+global+strategies%2C+and+a+malaria+control+crisis+in+South+America.&rft.au=Roberts%2C+D+R%3BLaughlin%2C+L+L%3BHsheih%2C+P%3BLegters%2C+L+J&rft.aulast=Roberts&rft.aufirst=D&rft.date=1997-07-01&rft.volume=3&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Emerging+infectious+diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-06 N1 - Date created - 1997-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Entomol. 1976 May 29;13(1):1-25 [781250] Bull Pan Am Health Organ. 1991;25(3):210-7 [1742567] Am J Trop Med Hyg. 1994;50(6 Suppl):21-34 [8024082] Comment In: Emerg Infect Dis. 1999 Mar-Apr;5(2):309-11 [10221895] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systemic, but not intraparenchymal, administration of 3-nitropropionic acid mimics the neuropathology of Huntington's disease: a speculative explanation. AN - 79157094; 9237266 AB - The mitochondrial toxin, 3-nitropropionic acid, has been introduced in recent years as a neurotoxin that can be administered systemically to model the many neurobehavioral correlates of Huntington's disease. In this update article, we discuss some of the many findings from experiments using the systemic 3-nitropropionic model, and provide some speculative explanations supporting this model over those utilizing conventional excitotoxins or direct intrastriatal application of 3-nitropropionic acid. We infer from our own studies and those of others that the slow process of neurodegeneration, probably through apoptotic mechanism, and the progressive locomotor dysfunctions (from dyskinesia to akinesia) inherent in Huntington's disease can be accomplished by chronic, low dose systemic administration of 3-nitropropionic acid in rodents as well as in non-human primates. This 3-nitropropionic acid model offers a new venue for investigating experimental treatment strategies for Huntington's disease. JF - Neuroscience research AU - Borlongan, C V AU - Nishino, H AU - Sanberg, P R AD - Department of Anatomy and Cell Biology, F. Edward Hebert School of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA. cborlong@usuhs.mil Y1 - 1997/07// PY - 1997 DA - July 1997 SP - 185 EP - 189 VL - 28 IS - 3 SN - 0168-0102, 0168-0102 KW - Neurotoxins KW - 0 KW - Nitro Compounds KW - Propionates KW - 3-nitropropionic acid KW - QY4L0FOX0D KW - Index Medicus KW - Rats KW - Nerve Degeneration -- drug effects KW - Animals KW - Neostriatum -- pathology KW - Injections KW - Propionates -- toxicity KW - Huntington Disease -- chemically induced KW - Neurotoxins -- administration & dosage KW - Propionates -- administration & dosage KW - Huntington Disease -- pathology KW - Neurotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79157094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+research&rft.atitle=Systemic%2C+but+not+intraparenchymal%2C+administration+of+3-nitropropionic+acid+mimics+the+neuropathology+of+Huntington%27s+disease%3A+a+speculative+explanation.&rft.au=Borlongan%2C+C+V%3BNishino%2C+H%3BSanberg%2C+P+R&rft.aulast=Borlongan&rft.aufirst=C&rft.date=1997-07-01&rft.volume=28&rft.issue=3&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Neuroscience+research&rft.issn=01680102&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-09-12 N1 - Date created - 1997-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Minimizing upper lip and incisor teeth paresthesias in approaches to transsphenoidal surgery. AN - 85214493; pmid-9215379 AB - Currently popular transsphenoidal approaches to the pituitary include sublabial, external rhinoplasty, alotomy, and transnasal techniques. The conventional sublabial approach remains the workhorse method despite postoperative lip edema, potential difficulty for denture wearers, and troublesome persistent upper lip and incisor teeth numbness. We traced the courses of the nasopalatine, infraorbital, and anterior superior alveolar nerves in 41 cadaveric half-head dissection to determine the exact contribution to upper lip and incisor teeth innervation. We then conducted a retrospective patient survey of 25 sublabial, 28 external rhinoplasty, 23 alotomy, and 12 transnasal approaches to the hypophysis to assess the incidence of upper lip and incisor teeth paresthesias lasting longer than 1 month. We conclude that rhinoplastic techniques are superior to the sublabial approach in limiting upper lip and incisor teeth numbness without compromising neurosurgical exposure for hypophysectomy. JF - Otolaryngology--Head and Neck Surgery AU - Schoem, S R AU - Khan, A AU - Wilson, W R AU - Laws, E R AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. PY - 1997 SP - 656 EP - 661 VL - 116 IS - 6 Pt 1 SN - 0194-5998, 0194-5998 KW - Cadaver KW - Lip KW - Pituitary Gland KW - Postoperative Complications KW - Human KW - Paresthesia KW - Rhinoplasty KW - Incisor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85214493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Minimizing+upper+lip+and+incisor+teeth+paresthesias+in+approaches+to+transsphenoidal+surgery.&rft.au=Schoem%2C+S+R%3BKhan%2C+A%3BWilson%2C+W+R%3BLaws%2C+E+R&rft.aulast=Schoem&rft.aufirst=S&rft.date=1997-06-01&rft.volume=116&rft.issue=6+Pt+1&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Sex differences in effects of predictable and unpredictable footshock on fentanyl self-administration in rats. AN - 79160466; 9234044 AB - An operant conditioning paradigm was used to examine effects of predictable and unpredictable footshock on oral fentanyl (50 micrograms/ml self-administration (SA) in 12 female and 12 male Wistar rats (Rattus norvegicus). Rats were tested for drug SA under a progressive ratio schedule with and without repeated predictable or unpredictable footshock over 8 weeks. Female rats consumed greater amounts of fentanyl than did male rats. Male rats exhibited greater withdrawal behaviors following naloxone challenge. Predictable footshock with repeated exposure (i.e., chronic stress) was accompanied by greater fentanyl SA than was unpredictable footshock, particularly for female rats. Corticosterone levels were positively correlated with fentanyl SA. Predictability of the stressor also had a greater effect on maintenance of fentanyl SA than it did on relapse to fentanyl SA. Results suggest that sex plays an important role in drug-taking behavior by rats. JF - Experimental and clinical psychopharmacology AU - Klein, L C AU - Popke, E J AU - Grunberg, N E AD - Department of Medical and Clinical Psychology, Uniformed Services, University of the Health Sciences (USUHS), Bethesda, Maryland 20814-4799, USA. Y1 - 1997/05// PY - 1997 DA - May 1997 SP - 99 EP - 106 VL - 5 IS - 2 SN - 1064-1297, 1064-1297 KW - Analgesics, Opioid KW - 0 KW - Fentanyl KW - UF599785JZ KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Sex Characteristics KW - Recurrence KW - Stress, Psychological -- blood KW - Rats KW - Behavior, Animal -- drug effects KW - Corticosterone -- blood KW - Rats, Wistar KW - Substance Withdrawal Syndrome -- psychology KW - Extinction, Psychological -- drug effects KW - Female KW - Male KW - Stress, Psychological -- psychology KW - Analgesics, Opioid -- pharmacology KW - Fentanyl -- pharmacology KW - Analgesics, Opioid -- administration & dosage KW - Electroshock KW - Fentanyl -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79160466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Sex+differences+in+effects+of+predictable+and+unpredictable+footshock+on+fentanyl+self-administration+in+rats.&rft.au=Klein%2C+L+C%3BPopke%2C+E+J%3BGrunberg%2C+N+E&rft.aulast=Klein&rft.aufirst=L&rft.date=1997-05-01&rft.volume=5&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-09-12 N1 - Date created - 1997-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tuberculosis skin test conversion among health care workers at a military medical center. AN - 79014628; 9155104 AB - Health care workers (HCW) are at risk of occupationally acquiring Mycobacterium tuberculosis (TB) infection. The Centers for Disease Control and Prevention has published guidelines for health care facilities to protect HCW. One of the recommended elements is TB infection surveillance among HCW using purified protein derivative (PPD) skin testing and analysis of the data by occupational group and work location to determine areas of increased risk of infection. At the military medical center (MMC) we studied, occupational groups with statistically significant (p 1.1%/year) included respiratory therapists (15.6%/year), nursing technicians (2.3%/year), and military personnel (1.6%/year). Maintenance and engineering workers (2.6%/year), food service workers (2.5%/year), laboratory workers (2.0%/year), custodial workers (1.8%/year), and practical nurses (1.7%/year) had above-average, but not statistically significant, risk. The fourth floor of the MMC had 39% (21/54) of the converters. The surveillance program also uncovered 235 individuals who had not completed adequate prophylactic therapy, and a case of active TB in a laboratory worker. JF - Military medicine AU - Ball, R AU - Van Wey, M AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Y1 - 1997/05// PY - 1997 DA - May 1997 SP - 338 EP - 343 VL - 162 IS - 5 SN - 0026-4075, 0026-4075 KW - Index Medicus KW - United States KW - Skin Tests KW - Humans KW - Risk Assessment KW - Allied Health Personnel KW - Infectious Disease Transmission, Patient-to-Professional KW - Occupational Diseases -- epidemiology KW - Tuberculosis -- epidemiology KW - Tuberculosis -- transmission KW - Population Surveillance KW - Military Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79014628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Tuberculosis+skin+test+conversion+among+health+care+workers+at+a+military+medical+center.&rft.au=Ball%2C+R%3BVan+Wey%2C+M&rft.aulast=Ball&rft.aufirst=R&rft.date=1997-05-01&rft.volume=162&rft.issue=5&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-06 N1 - Date created - 1997-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Past mental health or substance use treatment history and psychiatric differential diagnosis in consultation-liaison patients. AN - 79002346; 9136255 AB - The purpose of this study was to determine whether frequencies of any current primary or secondary (organic) psychiatric diagnoses in consultation-liaison (C-L) patients are associated with patient report of past history of mental health or substance use disorder treatment. Clinical information recorded in 134 C-L patients was retrospectively analyzed with the chi-square test, two-tailed, or Fisher's Exact Test when the sample sizes were < or = 5. The results revealed that the overall likelihood of the existence of a secondary psychiatric disorder diagnosis is elevated when there is no treatment history (P = 0.009). A primary psychiatric disorder is more likely to be diagnosed when there is treatment history (P = 0.009). Specific psychiatric diagnoses more likely to be present when there is no treatment history are organic mood disorder, depressed (P = 0.020) and adjustment disorder (P = 0.010). Specific diagnoses more likely to be present when there is treatment history are psychoactive substance-withdrawal syndrome (P = 0.014) and alcohol abuse or dependence (P = 0.028). The authors conclude that psychiatric treatment history can help C-L psychiatrists with differential diagnostic considerations. JF - Psychosomatics AU - Rundell, J R AU - Hall, R C AD - Department of Psychiatry, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland 20814-4799, USA. PY - 1997 SP - 262 EP - 268 VL - 38 IS - 3 SN - 0033-3182, 0033-3182 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Diagnosis, Differential KW - Substance Withdrawal Syndrome -- diagnosis KW - Humans KW - Adult KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Referral and Consultation KW - Psychiatry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79002346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatics&rft.atitle=Past+mental+health+or+substance+use+treatment+history+and+psychiatric+differential+diagnosis+in+consultation-liaison+patients.&rft.au=Rundell%2C+J+R%3BHall%2C+R+C&rft.aulast=Rundell&rft.aufirst=J&rft.date=1997-05-01&rft.volume=38&rft.issue=3&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Psychosomatics&rft.issn=00333182&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-30 N1 - Date created - 1997-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Roles of histidine-103 and tyrosine-235 in the function of the prolipoprotein diacylglyceryl transferase of Escherichia coli. AN - 78970391; 9139912 AB - Phosphatidylglycerol:prolipoprotein diacylglyceryl transferase (Lgt) is the first enzyme in the posttranslational sequence of reactions resulting in the lipid modification of lipoproteins in bacteria. A previous comparison of the primary sequences of the Lgt enzymes from phylogenetically distant bacterial species revealed several highly conserved amino acid sequences throughout the molecule; the most extensive of these was the region 103HGGLIG108 in the Escherichia coli Lgt (H.-Y. Qi, K. Sankaran, K. Gan, and H. C. Wu, J. Bacteriol. 177:6820-6824, 1995). These studies also revealed that the kinetics of inactivation of E. coli Lgt with diethylpyrocarbonate were consistent with the modification of a single essential histidine or tyrosine residue. The current study was conducted in an attempt to identify this essential amino acid residue in order to further define structure-function relationships in Lgt. Accordingly, all of the histidine residues and seven of the tyrosine residues of E. coli Lgt were altered by site-directed mutagenesis, and the in vitro activities of the altered enzymes, as well the abilities of the respective mutant lgt alleles to complement the temperature-sensitive phenotype of E. coli SK634 defective in Lgt activity, were determined. The data obtained from these studies, in conjunction with additional chemical inactivation studies, support the conclusion that His-103 is essential for Lgt activity. These studies also indicated that Tyr-235 plays an important role in the function of this enzyme. Although other histidine and tyrosine residues were not found to be essential for Lgt activity, alterations of His-196 resulted in a significant reduction of in vitro activity. JF - Journal of bacteriology AU - Sankaran, K AU - Gan, K AU - Rash, B AU - Qi, H Y AU - Wu, H C AU - Rick, P D AD - Department of Microbiology and Immunology, The Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1997/05// PY - 1997 DA - May 1997 SP - 2944 EP - 2948 VL - 179 IS - 9 SN - 0021-9193, 0021-9193 KW - Peptide Fragments KW - 0 KW - Recombinant Proteins KW - Tyrosine KW - 42HK56048U KW - Histidine KW - 4QD397987E KW - Transferases KW - EC 2.- KW - phosphatidylglycerol glyceryl transferase KW - EC 2.4.99.- KW - Diethyl Pyrocarbonate KW - LMR3LZG146 KW - Index Medicus KW - Phylogeny KW - Mutagenesis, Site-Directed KW - Peptide Fragments -- chemistry KW - Conserved Sequence KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Point Mutation KW - Molecular Sequence Data KW - Genetic Complementation Test KW - Diethyl Pyrocarbonate -- pharmacology KW - Amino Acid Sequence KW - Recombinant Proteins -- chemistry KW - Structure-Activity Relationship KW - Transferases -- chemistry KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology KW - Transferases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78970391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Roles+of+histidine-103+and+tyrosine-235+in+the+function+of+the+prolipoprotein+diacylglyceryl+transferase+of+Escherichia+coli.&rft.au=Sankaran%2C+K%3BGan%2C+K%3BRash%2C+B%3BQi%2C+H+Y%3BWu%2C+H+C%3BRick%2C+P+D&rft.aulast=Sankaran&rft.aufirst=K&rft.date=1997-05-01&rft.volume=179&rft.issue=9&rft.spage=2944&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-29 N1 - Date created - 1997-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anal Biochem. 1976 Jul;74(1):160-70 [786067] J Bacteriol. 1995 Dec;177(23):6820-4 [7592473] J Biol Chem. 1984 Mar 25;259(6):3825-30 [6368552] Proc Natl Acad Sci U S A. 1985 Feb;82(4):1074-8 [3156376] J Bacteriol. 1989 Jan;171(1):565-8 [2644208] Methods Enzymol. 1992;209:321-30 [1323048] J Biol Chem. 1993 Aug 5;268(22):16544-50 [8344935] J Biol Chem. 1993 Aug 5;268(22):16551-6 [8344936] Adv Protein Chem. 1994;45:53-88 [8154374] J Biol Chem. 1994 Aug 5;269(31):19701-6 [8051048] J Bacteriol. 1995 Apr;177(7):1879-82 [7896715] Methods Enzymol. 1995;249:91-119 [7791629] Science. 1995 Jul 28;269(5223):496-512 [7542800] Methods Enzymol. 1995;250:683-97 [7651187] Methods Enzymol. 1995;248:169-80 [7674920] Science. 1995 Oct 20;270(5235):397-403 [7569993] Methods Enzymol. 1977;47:431-42 [22021] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene. AN - 78913255; 9092581 AB - The expression of human squalene synthase (HSS) gene is transcriptionally regulated in HepG-2 cells, up to 10-fold, by variations in cellular cholesterol homeostasis. An earlier deletion analysis of the 5'-flanking region of the HSS gene demonstrated that most of the HSS promoter activity is detected within a 69-base pair sequence located between nucleotides -131 and -200. ADD1/SREBP-1c, a rat homologue of sterol regulatory element-binding protein (SREBP)-1c binds to sterol regulatory element (SRE)-1-like sequence (HSS-SRE-1) present in this region (Guan, G., Jiang, G., Koch, R. L. and Shechter, I. (1995) J. Biol. Chem. 270, 21958-21965). In our present study, we demonstrate that mutation of this HSS-SRE-1 element significantly reduced, but did not abolish, the response of HSS promoter to change in sterol concentration. Mutation scanning indicates that two additional DNA promoter sequences are involved in sterol-mediated regulation. The first sequence contains an inverted SRE-3 element (Inv-SRE-3) and the second contains an inverted Y-box (Inv-Y-box) sequence. A single mutation in any of these sequences reduced, but did not completely remove, the response to sterols. Combination mutation studies showed that the HSS promoter activity was abolished only when all three elements were mutated simultaneously. Co-expression of SRE-1- or SRE-2-binding proteins (SREBP-1 or SREBP-2) with HSS promoter-luciferase reporter resulted in a dramatic increase of HSS promoter activity. Gel mobility shift studies indicate differential binding of the SREBPs to regulatory sequences in the HSS promoter. These results indicate that the transcription of the HSS gene is regulated by multiple regulatory elements in the promoter. JF - The Journal of biological chemistry AU - Guan, G AU - Dai, P H AU - Osborne, T F AU - Kim, J B AU - Shechter, I AD - Department of Biochemistry, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1997/04/11/ PY - 1997 DA - 1997 Apr 11 SP - 10295 EP - 10302 VL - 272 IS - 15 SN - 0021-9258, 0021-9258 KW - CCAAT-Enhancer-Binding Proteins KW - 0 KW - DNA-Binding Proteins KW - Nuclear Proteins KW - SREBF1 protein, human KW - SREBF2 protein, human KW - Srebf1 protein, rat KW - Sterol Regulatory Element Binding Protein 1 KW - Sterol Regulatory Element Binding Protein 2 KW - Transcription Factors KW - Farnesyl-Diphosphate Farnesyltransferase KW - EC 2.5.1.21 KW - Index Medicus KW - Animals KW - Transcription Factors -- metabolism KW - Humans KW - Leucine Zippers KW - Mutagenesis, Site-Directed KW - Rats KW - Base Sequence KW - Promoter Regions, Genetic KW - Helix-Loop-Helix Motifs KW - Tumor Cells, Cultured KW - Molecular Sequence Data KW - Nuclear Proteins -- metabolism KW - DNA-Binding Proteins -- metabolism KW - Gene Expression Regulation, Enzymologic KW - Farnesyl-Diphosphate Farnesyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78913255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Multiple+sequence+elements+are+involved+in+the+transcriptional+regulation+of+the+human+squalene+synthase+gene.&rft.au=Guan%2C+G%3BDai%2C+P+H%3BOsborne%2C+T+F%3BKim%2C+J+B%3BShechter%2C+I&rft.aulast=Guan&rft.aufirst=G&rft.date=1997-04-11&rft.volume=272&rft.issue=15&rft.spage=10295&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-15 N1 - Date created - 1997-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical manifestations of Plasmodium falciparum malaria experimentally induced by mosquito challenge. AN - 78928728; 9086149 AB - To determine the characteristics of clinical illness accompanying Plasmodium falciparum infection induced by controlled exposure to infected mosquitoes, records of 118 volunteers participating in studies conducted between 1985 and 1992 were reviewed. One hundred fourteen volunteers (97%) reported at least one symptom attributable to malaria, with fatigue, myalgias or arthralgias, headache, and chills most commonly reported. The median duration of symptoms was 3 days. Fever was recorded in 61% of volunteers; 4 volunteers had temperatures >40 degrees C. Neutropenia and thrombocytopenia were present in 9% and 12% of volunteers, respectively. Despite counts as low as 658/microL (neutrophils) or 73,000/microL (platelets), no secondary infectious or hemorrhagic complications occurred. In all cases, volunteers recovered completely and laboratory values returned to baseline after specific antimalarial therapy. Recrudescence did not occur in any volunteer. In this model, mosquito inoculation of P. falciparum is a reliable, safe, and well-tolerated method of experimental challenge. JF - The Journal of infectious diseases AU - Church, L W AU - Le, T P AU - Bryan, J P AU - Gordon, D M AU - Edelman, R AU - Fries, L AU - Davis, J R AU - Herrington, D A AU - Clyde, D F AU - Shmuklarsky, M J AU - Schneider, I AU - McGovern, T W AU - Chulay, J D AU - Ballou, W R AU - Hoffman, S L AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 1997/04// PY - 1997 DA - April 1997 SP - 915 EP - 920 VL - 175 IS - 4 SN - 0022-1899, 0022-1899 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Humans KW - Adult KW - Retrospective Studies KW - Insect Bites and Stings KW - Parasitemia -- etiology KW - Middle Aged KW - Adolescent KW - Male KW - Leukocyte Count KW - Female KW - Platelet Count KW - Insect Vectors -- parasitology KW - Malaria, Falciparum -- blood KW - Malaria, Falciparum -- complications KW - Malaria, Falciparum -- transmission KW - Anopheles -- parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78928728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Clinical+manifestations+of+Plasmodium+falciparum+malaria+experimentally+induced+by+mosquito+challenge.&rft.au=Church%2C+L+W%3BLe%2C+T+P%3BBryan%2C+J+P%3BGordon%2C+D+M%3BEdelman%2C+R%3BFries%2C+L%3BDavis%2C+J+R%3BHerrington%2C+D+A%3BClyde%2C+D+F%3BShmuklarsky%2C+M+J%3BSchneider%2C+I%3BMcGovern%2C+T+W%3BChulay%2C+J+D%3BBallou%2C+W+R%3BHoffman%2C+S+L&rft.aulast=Church&rft.aufirst=L&rft.date=1997-04-01&rft.volume=175&rft.issue=4&rft.spage=915&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-17 N1 - Date created - 1997-04-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Infect Dis. 1998 Jun;177(6):1776-7 [9607876] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hyperbaric dye solution distribution characteristics after pencil-point needle injection in a spinal cord model. AN - 78921933; 9105241 AB - The flow-rate limiting and directional characteristics of caudally directed microcatheters, which lead to intrathecal maldistribution of hyperbaric 5% lidocaine, are believed to have contributed to at least 11 cases of cauda equina syndrome. The authors investigated the distribution characteristics of hyperbaric dye solutions via caudally directed side port needles at various rates of injection in a spinal cord model to determine the potential for maldistribution. Using a digital video image processing technique, we injected a hyperbaric solution of phthalocyanine blue dye through caudally directed side-port needles into a supinely oriented transparent spinal canal model filled with simulated cerebrospinal fluid. Injections via commonly used spinal needles (24-gauge and 25-gauge Sprotte, and 25-gauge and 27-gauge Whitacre) were recorded using five injection rates (2, 4, 6, 8, and 16 ml/min). For all needles tested, injection rate had a significant effect on the peak dye concentration (P or = 6 ml/min (2 ml/20 s) resulted in peak dye concentrations of less than 168 mg/1 (extrapolated concentration of 1% lidocaine). Injection via the 24-gauge Sprotte needle, which has a larger orifice area and internal diameter, resulted in significantly lower peak dye concentrations than via the smaller Whitacre needles tested (P < 0.05). Sacral maldistribution could be minimized by using injection rates > or = 6 ml/min (2 ml/20 s), for all of the side-port spinal needles used in this model study. When very slow injection rates (2 ml/min) are used, peak dye concentrations varied inversely and significantly with needle internal diameter and orifice area. JF - Anesthesiology AU - Holman, S J AU - Robinson, R A AU - Beardsley, D AU - Stewart, S F AU - Klein, L AU - Stevens, R A AD - Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 1997/04// PY - 1997 DA - April 1997 SP - 966 EP - 973 VL - 86 IS - 4 SN - 0003-3022, 0003-3022 KW - Anesthetics, Local KW - 0 KW - Coloring Agents KW - Indoles KW - Organometallic Compounds KW - copper phthalocyanine KW - 3VEX9T7UT5 KW - Lidocaine KW - 98PI200987 KW - Abridged Index Medicus KW - Index Medicus KW - Needles KW - Lidocaine -- adverse effects KW - Injections KW - Lidocaine -- pharmacokinetics KW - Organometallic Compounds -- pharmacokinetics KW - Indoles -- pharmacokinetics KW - Spinal Cord -- metabolism KW - Coloring Agents -- pharmacokinetics KW - Anesthetics, Local -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78921933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Hyperbaric+dye+solution+distribution+characteristics+after+pencil-point+needle+injection+in+a+spinal+cord+model.&rft.au=Holman%2C+S+J%3BRobinson%2C+R+A%3BBeardsley%2C+D%3BStewart%2C+S+F%3BKlein%2C+L%3BStevens%2C+R+A&rft.aulast=Holman&rft.aufirst=S&rft.date=1997-04-01&rft.volume=86&rft.issue=4&rft.spage=966&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-01 N1 - Date created - 1997-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methods of testing and analyzing excito-repellency responses of malaria vectors to insecticides. AN - 79010463; 9152869 AB - A new test system that includes an excito-repellency test box, test procedures, and statistical treatment of data is described. The method consists of enclosing 25 mosquitoes in an exposure chamber lined with insecticide-treated or untreated (control) test papers. Each chamber has a single portal for mosquitoes to escape to a receiving cage, and numbers escaping are manually recorded at 1-min intervals. The exposure chamber accommodates a screened, 2nd chamber that, when placed in the exposure chamber, prevents the mosquitoes from making physical contact with test papers. A full assay utilized one exposure chamber that permits physical contact with insecticide-treated papers, one chamber that permits physical contact with control papers, one chamber that prevents physical contact with insecticide-treated papers, and a 4th chamber that prevents contact with control papers. After insecticide exposure, test populations are held for observations on 24-h mortalities. A survival analysis approach is described for estimating mosquito escape rates and for comparing differences in mosquito escape rates, with or without physical contact with insecticide, among populations, insecticides, and doses of insecticide. JF - Journal of the American Mosquito Control Association AU - Roberts, D R AU - Chareonviriyaphap, T AU - Harlan, H H AU - Hshieh, P AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 1997/03// PY - 1997 DA - March 1997 SP - 13 EP - 17 VL - 13 IS - 1 SN - 8756-971X, 8756-971X KW - Insecticides KW - 0 KW - Index Medicus KW - Animals KW - Insect Vectors KW - Culicidae KW - Mosquito Control -- methods KW - Malaria -- prevention & control KW - Mosquito Control -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79010463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Mosquito+Control+Association&rft.atitle=Methods+of+testing+and+analyzing+excito-repellency+responses+of+malaria+vectors+to+insecticides.&rft.au=Roberts%2C+D+R%3BChareonviriyaphap%2C+T%3BHarlan%2C+H+H%3BHshieh%2C+P&rft.aulast=Roberts&rft.aufirst=D&rft.date=1997-03-01&rft.volume=13&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Mosquito+Control+Association&rft.issn=8756971X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-07-02 N1 - Date created - 1997-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synthetic trehalose dicorynomycolate (S-TDCM): behavioral effects and radioprotection. AN - 79008881; 9164080 AB - This study evaluated synthetic trehalose dicorynomycolate (S-TDCM), an immunomodulator, for its survival enhancing capacity and behavioral toxicity in B6D2F1 female mice. In survival experiments, mice were administered S-TDCM (25-400 micrograms/mouse i.p.) 20-24 hr before 5.6 Gy mixed-field fission-neutron irradiation (n) and gamma-photon irradiation. The 30-day survival rates for mice treated with 100-400 micrograms/mouse S-TDCM were significantly enhanced compared to controls. Toxicity of S-TDCM was measured in nonirradiated mice by locomotor activity, food intake, water consumption, and alterations in body weight. A dose-dependent decrease was noted in all behavioral measures in mice treated with S-TDCM. Doses of 100 and 200 micrograms/mouse S-TDCM significantly reduced motor activity beginning 12 hr postinjection with recovery by 24 hr. A dose of 400 micrograms/mouse significantly decreased activity within the first 4 hr after administration and returned to control levels by 32 hr following injection. Food and water intake were significantly depressed at doses of 200 and 400 micrograms/mouse on the day following drug administration, and were recovered in 24 hr. Body weight was significantly decreased in the 200 micrograms/mouse group for 2 days and in the 400 micrograms/mouse group for 4 days following injection. A dose of 100 micrograms/mouse effectively enhanced survival after fission-neutron irradiation with no adverse effect on food consumption, water intake, or body weight and a minimal, short-term effect on locomotor activity. JF - Journal of radiation research AU - Landauer, M R AU - McChesney, D G AU - Ledney, G D AD - Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5603, USA. landauer@vax.afrri.usuhs.mil Y1 - 1997/03// PY - 1997 DA - March 1997 SP - 45 EP - 54 VL - 38 IS - 1 SN - 0449-3060, 0449-3060 KW - Adjuvants, Immunologic KW - 0 KW - Cord Factors KW - Radiation-Protective Agents KW - 6,6'-dicorynomycolyl trehalose KW - 93379-98-7 KW - Index Medicus KW - Eating -- drug effects KW - Animals KW - Drinking -- radiation effects KW - Drinking -- drug effects KW - Motor Activity -- radiation effects KW - Motor Activity -- drug effects KW - Mice KW - Eating -- radiation effects KW - Female KW - Behavior, Animal -- drug effects KW - Adjuvants, Immunologic -- toxicity KW - Radiation-Protective Agents -- toxicity KW - Cord Factors -- toxicity KW - Radiation-Protective Agents -- pharmacology KW - Behavior, Animal -- radiation effects KW - Adjuvants, Immunologic -- pharmacology KW - Cord Factors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79008881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+radiation+research&rft.atitle=Synthetic+trehalose+dicorynomycolate+%28S-TDCM%29%3A+behavioral+effects+and+radioprotection.&rft.au=Landauer%2C+M+R%3BMcChesney%2C+D+G%3BLedney%2C+G+D&rft.aulast=Landauer&rft.aufirst=M&rft.date=1997-03-01&rft.volume=38&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+radiation+research&rft.issn=04493060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-07-07 N1 - Date created - 1997-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The York Mason approach to repair of iatrogenic rectourinary fistulae. AN - 78918805; 9124629 AB - We report our experience of 8 patients who underwent repair of iatrogenic rectourinary fistulae via the transsphincteric (York Mason) approach. Eight patients developed rectourinary fistulae in the course of treatment of prostate cancer. Three fistulae developed after radiation therapy alone, three after prostatectomy, and two after both surgery and radiation therapy. Five patients underwent fecal diversion in conjunction with repair. All fistulae remained closed after repair. All patients were continent of stool after primary surgery or after colostomy closure if they had been diverted. Two patients had complications associated with urethral catheters that resolved with changing the catheters. The transsphincteric (York Mason) approach in the repair of rectourinary fistulae results in successful closure of the fistulae without impairment of continence to stool. This procedure is much simpler than complicated transabdominal or transperineal approaches to these fistulae. JF - American journal of surgery AU - Fengler, S A AU - Abcarian, H AD - Department of Surgery, F. Edward Herbert School of Medicine, Uniformed Services University of the Health Sciences, Ft. Sam Houston, Texas, USA. Y1 - 1997/03// PY - 1997 DA - March 1997 SP - 213 EP - 217 VL - 173 IS - 3 SN - 0002-9610, 0002-9610 KW - Abridged Index Medicus KW - Index Medicus KW - Prostatectomy -- adverse effects KW - Postoperative Complications KW - Prostatic Neoplasms -- surgery KW - Humans KW - Aged KW - Middle Aged KW - Radiation Injuries -- surgery KW - Surgical Procedures, Operative -- methods KW - Prostatic Neoplasms -- radiotherapy KW - Male KW - Rectal Fistula -- etiology KW - Urinary Fistula -- surgery KW - Rectal Fistula -- surgery KW - Urinary Fistula -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78918805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+surgery&rft.atitle=The+York+Mason+approach+to+repair+of+iatrogenic+rectourinary+fistulae.&rft.au=Fengler%2C+S+A%3BAbcarian%2C+H&rft.aulast=Fengler&rft.aufirst=S&rft.date=1997-03-01&rft.volume=173&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=American+journal+of+surgery&rft.issn=00029610&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-24 N1 - Date created - 1997-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recombination between a resident plasmid and the chromosome following irradiation of the radioresistant bacterium Deinococcus radiodurans AN - 15860420; 4017065 AB - Interplasmidic and intrachromosomal recombination in Deinococcus radiodurans has been studied recently and has been found to occur at high frequency following exposure to ionizing radiation. In the current work, we document plasmid-chromosome recombination following exposure of D. radiodurans to 1.75 Mrad (17.5 kGy) 60Co, when the plasmid is present in the cell at the time of irradiation. Recombination is assayed using both physical and allelic polymorphisms of homologous genes in the plasmid and chromosome. Recombination was found to be largely, but not entirely, recA-dependent. Crossovers occur frequently, and a significant fraction of these are non-reciprocal. JF - Gene AU - Daly, MJ AU - Minton, K W AD - Department of Pathology, F.E. Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799 USA Y1 - 1997/03// PY - 1997 DA - Mar 1997 SP - 225 EP - 229 PB - ELSEVIER SCIENCE B.V. VL - 187 IS - 2 SN - 0378-1119, 0378-1119 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - chromosomes KW - recombination KW - plasmids KW - Deinococcus radiodurans KW - gamma radiation KW - G 07203:Plasmids KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15860420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Recombination+between+a+resident+plasmid+and+the+chromosome+following+irradiation+of+the+radioresistant+bacterium+Deinococcus+radiodurans&rft.au=Daly%2C+MJ%3BMinton%2C+K+W&rft.aulast=Daly&rft.aufirst=MJ&rft.date=1997-03-01&rft.volume=187&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Deinococcus radiodurans; recombination; gamma radiation; plasmids; chromosomes ER - TY - JOUR T1 - Induction of the heat shock response prevents tissue injury during acute inflammation of the rat ileum. AN - 78828425; 9034270 AB - To determine if prior total body hyperthermia protected against subsequent acute ileitis induced by the cytotoxic lectin, ricin, in rats. The time course of heat shock mRNA and protein expression in the ileum was determined. The effects of heat stress on small intestinal mucosal integrity, arachidonic acid metabolism, and neutrophilic infiltrate were compared in heated and nonheated rats receiving vehicle or ricin intraluminally. The effect of hyperthermia on the circulating neutrophil superoxide production was also evaluated. Prospective, randomized, controlled trial. University research laboratory. Forty-one adult, male Sprague-Dawley rats, weighing 150 to 250 g, and 32 adult, inbred, male Fisher 344 rats, weighing 175 to 250 g. Exposure to whole body hyperthermia and production of acute ileitis. Sprague-Dawley rats were divided randomly into four experimental groups: nonheated control group, heated control group, nonheated ricin group (1 mg/mL water, intraluminal), and heated ricin group. Sprague-Dawley rats in a separate study were assigned to seven groups based on the time of removal of the terminal ileum following hyperthermia: 0 min, or 1, 2, 4, 8, 12, and 24 hrs. Inbred Fisher 344 rats were allocated to the heated and nonheated groups for peripheral neutrophil superoxide generation studies. Whole body hyperthermia to a rectal temperature of 41 degrees C to 42 degrees C for 15 to 20 mins: a) was associated with marked mucosal cytoprotection against subsequent ricin-induced ileitis (Injury grade [from 0 = normal to 5 = severe]: 0.4 +/- 0.1 vs. 2.5 +/- 0.2, p < .001); b) prevented the ricin-induced reduction in villus height to crypt depth ratio (2.4 +/- 0.1 vs. 1.9 +/- 0.1, p < .01); and c) significantly reduced the number of infiltrating neutrophils when compared with nonheated ricin-treated rats (11 +/- 2 vs. 32 +/- 3 neutrophils/high-power field, p < .001). The hyperthermia-induced peak increase in heat shock protein (HSP)-70 mRNA at 2 hrs preceded that of HSP 70i at 4 hrs. Heat shock significantly reduced the ricin-induced increase in both basal (8.0 +/- 1.9 vs. 33.0 +/- 8.1 pg of leukotriene B4/mg protein, p < .05) and ionophore-stimulated (16.0 +/- 4.9 vs. 80.0 +/- 15.5 pg of leukotriene B4/mg protein, p < .001) generation of ileal leukotriene B4, but did not alter the cyclooxygenase product, prostaglandin E2. Hyperthermia did not alter peripheral neutrophil superoxide production. This study assessed the effects of heat shock in the normal and acutely inflamed intestine. These data suggest that heat stress and increased expression of HSP 70i protect against acute intestinal inflammation. This protection is associated with significant reductions in ileal leukotriene B4 generation and neutrophilic infiltrate. Hyperthermia did not alter circulating neutrophil superoxide production. Thus, the mechanism of heat stress protection against acute ileitis may involve local intestinal inhibition of leukotriene B4 production and subsequent neutrophilic infiltration without altering the ability of systemic neutrophils to be activated. JF - Critical care medicine AU - Stojadinovic, A AU - Kiang, J AU - Goldhill, J AU - Matin, D AU - Smallridge, R AU - Galloway, R AU - Shea-Donohue, T AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 1997/02// PY - 1997 DA - February 1997 SP - 309 EP - 317 VL - 25 IS - 2 SN - 0090-3493, 0090-3493 KW - Heat-Shock Proteins KW - 0 KW - Ricin KW - 9009-86-3 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Polymerase Chain Reaction KW - Animals KW - Rats, Sprague-Dawley KW - Rats, Inbred F344 KW - Male KW - Ileitis -- chemically induced KW - Ricin -- toxicity KW - Heat-Shock Proteins -- physiology KW - Ileum -- metabolism KW - Heat-Shock Proteins -- biosynthesis KW - Ileitis -- pathology KW - Ileitis -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78828425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+care+medicine&rft.atitle=Induction+of+the+heat+shock+response+prevents+tissue+injury+during+acute+inflammation+of+the+rat+ileum.&rft.au=Stojadinovic%2C+A%3BKiang%2C+J%3BGoldhill%2C+J%3BMatin%2C+D%3BSmallridge%2C+R%3BGalloway%2C+R%3BShea-Donohue%2C+T&rft.aulast=Stojadinovic&rft.aufirst=A&rft.date=1997-02-01&rft.volume=25&rft.issue=2&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Critical+care+medicine&rft.issn=00903493&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-11 N1 - Date created - 1997-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Poetics of Identity AN - 61473742; 9712499 AB - Argues that imaginings influence the construction of identity, based on the Quixotic principle; ie, imaginings stimulated by stories can provide the plot structures for individuals' self-narratives. This principle is illustrated with an autobiographical account & two historical case studies. Analysis is extended to the contemporary concern of domestic terrorism, claiming cultural myths provide the imaginings that serve as a framework for adopting the dramatic role of hero. It is suggested that the plot structure of the deeply entrenched myth of the frontier -- regeneration through violence -- contains the justification for the actions of some domestic terrorists. 37 References. Adapted from the source document. JF - Theory & Psychology AU - Sarbin, Theodore R AD - 25515 Hatton Rd, Carmel CA 93923 5211p@vm1.cc.nps.navy.mil Y1 - 1997/02// PY - 1997 DA - February 1997 SP - 67 EP - 82 VL - 7 IS - 1 SN - 0959-3543, 0959-3543 KW - identity construction, imagining's role, domestic terrorism KW - cultural myths KW - autobiographical account, case studies KW - Terrorism KW - Myths KW - Self Concept KW - Identity KW - Narratives KW - article KW - 0312: social psychology; personality & social roles (individual traits, social identity, adjustment, conformism, & deviance) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61473742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Theory+%26+Psychology&rft.atitle=The+Poetics+of+Identity&rft.au=Sarbin%2C+Theodore+R&rft.aulast=Sarbin&rft.aufirst=Theodore&rft.date=1997-02-01&rft.volume=7&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Theory+%26+Psychology&rft.issn=09593543&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - THPSEJ N1 - SubjectsTermNotLitGenreText - Myths; Identity; Terrorism; Narratives; Self Concept ER - TY - JOUR T1 - Parallel dermal subcompartments for modeling chemical absorption. AN - 79564136; 9501509 AB - Understanding the absorption of chemicals through the skin is of importance to many fields of study. Biologically-based models can be used to simulate the absorption process and predict the rate of absorption and the amount of the chemical in various parts of the body and skin. When these models consist of physiological and biochemical parameters that can be measured, they can be extremely useful. When a model is appropriately validated, the results can be extrapolated across species to predict the effect of human exposure. In this paper we develop two new physiologically-based pharmacokinetic (PBPK) models which predict the concentration of Dibromomethane in the blood of rats after dermal vapor exposure. These two new models expand a previously developed homogeneous skin model by adding parallel skin subcompartments to represent skin appendages and layered subcompartments to represent the distinct layers of the skin. The predictions of these new models match the experimental data better than the original homogeneous model, as well as being more physiologically descriptive. Sensitivity analysis showed us which parameters were the most sensitive to change and thus revealing the parameters we should be most concerned with measuring. After being properly validated, these models could be a great improvement over previous models in the ability to extrapolate results for different species, doses, and durations. JF - SAR and QSAR in environmental research AU - Bookout, R L AU - Quinn, D W AU - McDougal, J N AD - Air Force Institute of Technology, Wright-Patterson AFB, OH 45433, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 259 EP - 279 VL - 7 IS - 1-4 SN - 1062-936X, 1062-936X KW - Hydrocarbons, Brominated KW - 0 KW - Mutagens KW - Xenobiotics KW - methylene bromide KW - V69B659W01 KW - Index Medicus KW - Sensitivity and Specificity KW - Rats KW - Animals KW - Humans KW - Forecasting KW - Models, Biological KW - Hydrocarbons, Brominated -- pharmacokinetics KW - Xenobiotics -- pharmacokinetics KW - Skin Absorption KW - Mutagens -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79564136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SAR+and+QSAR+in+environmental+research&rft.atitle=Parallel+dermal+subcompartments+for+modeling+chemical+absorption.&rft.au=Bookout%2C+R+L%3BQuinn%2C+D+W%3BMcDougal%2C+J+N&rft.aulast=Bookout&rft.aufirst=R&rft.date=1997-01-01&rft.volume=7&rft.issue=1-4&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=SAR+and+QSAR+in+environmental+research&rft.issn=1062936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-26 N1 - Date created - 1998-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biological drivenness: a relative indication for paternalism. AN - 79517590; 9436089 JF - The Journal of clinical ethics AU - Howe, E G AD - Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 307 EP - 312 VL - 8 IS - 3 SN - 1046-7890, 1046-7890 KW - Bioethics KW - Index Medicus KW - Professional Patient Relationship KW - Humans KW - Mental Competency KW - Personal Autonomy KW - Alcoholism -- psychology KW - Male KW - Female KW - Treatment Refusal -- psychology KW - Mentally Ill Persons KW - Ethics, Medical KW - Decision Making KW - Physician-Patient Relations KW - Paternalism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79517590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+ethics&rft.atitle=Biological+drivenness%3A+a+relative+indication+for+paternalism.&rft.au=Howe%2C+E+G&rft.aulast=Howe&rft.aufirst=E&rft.date=1997-01-01&rft.volume=8&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+ethics&rft.issn=10467890&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-06 N1 - Date created - 1998-03-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Clin Ethics. 1997 Fall;8(3):303-6 [9436088] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Musculoskeletal-related disability in US Army personnel: prevalence, gender, and military occupational specialties. AN - 78809338; 9029434 AB - Research on military populations indicates that musculoskeletal-related disorders represent a prevalent source of outpatient visits, lost work time, hospitalization, and disability. Despite the increasing role of women in the military, little is known regarding the association among military occupations, gender, and disability. The study presented here analyzed 41,750 disability cases to determine: (1) prevalence of work-related musculoskeletal disability, (2) specific jobs associated with greater risk of musculoskeletal disability, and (3) association among gender, job-type, and disability. Results indicate: (1) back-related disorders represent the most prevalent sources of disability, (2) certain occupations were associated with higher disability risk, (3) women experienced higher overall, and musculoskeletal, disability risk, and (4) specific jobs were identified in which women experienced higher rates of musculoskeletal disability. These findings highlight the need to consider the interaction between workplace factors and gender on disability in the military work force. JF - Journal of occupational and environmental medicine AU - Feuerstein, M AU - Berkowitz, S M AU - Peck, C A AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 1997/01// PY - 1997 DA - January 1997 SP - 68 EP - 78 VL - 39 IS - 1 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - United States KW - Humans KW - Adult KW - Disability Evaluation KW - Middle Aged KW - Occupations -- classification KW - Sex Distribution KW - Male KW - Female KW - Prevalence KW - Age Distribution KW - Military Personnel KW - Occupational Diseases -- epidemiology KW - Musculoskeletal Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78809338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Musculoskeletal-related+disability+in+US+Army+personnel%3A+prevalence%2C+gender%2C+and+military+occupational+specialties.&rft.au=Feuerstein%2C+M%3BBerkowitz%2C+S+M%3BPeck%2C+C+A&rft.aulast=Feuerstein&rft.aufirst=M&rft.date=1997-01-01&rft.volume=39&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-15 N1 - Date created - 1997-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of retroperitoneal lymphadenectomy in mature teratoma of the testis. AN - 78779579; 8976241 AB - Pure testicular teratoma is rare in adulthood with an incidence of 5%. Pure teratoma is considered less aggressive and less likely to metastasize than other nonseminomatous germ cell tumors. Therefore, patients with mature teratoma have been considered candidates for surveillance protocols. We report our experience with 44 cases of primary pure testicular teratoma. We retrospectively identified 44 patients (5.7%) with primary pure teratoma of the testis of the 772 treated for testicular germ cell tumors at our institutions. Archival tumor blocks were available for pathological reevaluation and serial sections were obtained in all cases. A total of 35 patients (79.5%) who presented with clinical low stage disease, including stage I in 26 (59.1%) and stage IIA/B in 9 (20.4%), underwent radical orchiectomy followed by retroperitoneal lymphadenectomy. Nine patients (20.5%) who presented with clinically advanced disease (stages IIC to IV) were treated with primary chemotherapy and secondary retroperitoneal lymphadenectomy of residual masses. The frequency of lymph node metastases was 19.2% in clinical stage I disease and 66% in stage IIA/B. Histopathological diagnosis of mature teratoma was confirmed in all cases. However, of 20 patients 16 (80%) had scars or calcifications in the adjacent parenchyma, indicating a burned out tumor, and 4 (20%) had microfocal embryonal carcinoma. None of the patients with clinical stage I disease had relapse during followup and the relapse rate in those with stage IIA/B disease was 33%. Median followup was 97 months (range 24 to 250). Overall 43% of patients with pure teratoma presented with metastatic disease. Our data demonstrate the malignant potential of pure testicular mature teratoma. Based on our results metastases in testicular mature teratoma seem to result from metastasizing nongerm cell components undergoing early regression, as demonstrated by the high frequency of burned out tumors. We recommend that serial sections be taken of the orchiectomy specimen in all cases of pure mature teratoma to determine adequate management: retroperitoneal lymphadenectomy in cases of associated scars, calcifications or microfocal malignant germ cell components and surveillance in cases of pure mature teratoma. JF - The Journal of urology AU - Heidenreich, A AU - Moul, J W AU - McLeod, D G AU - Mostofi, F K AU - Engelmann, U H AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 1997/01// PY - 1997 DA - January 1997 SP - 160 EP - 163 VL - 157 IS - 1 SN - 0022-5347, 0022-5347 KW - Abridged Index Medicus KW - Index Medicus KW - Lymphatic Metastasis KW - Humans KW - Retrospective Studies KW - Retroperitoneal Space KW - Follow-Up Studies KW - Male KW - Lymph Node Excision -- methods KW - Testicular Neoplasms -- pathology KW - Testicular Neoplasms -- surgery KW - Teratoma -- secondary KW - Teratoma -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78779579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=The+role+of+retroperitoneal+lymphadenectomy+in+mature+teratoma+of+the+testis.&rft.au=Heidenreich%2C+A%3BMoul%2C+J+W%3BMcLeod%2C+D+G%3BMostofi%2C+F+K%3BEngelmann%2C+U+H&rft.aulast=Heidenreich&rft.aufirst=A&rft.date=1997-01-01&rft.volume=157&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-30 N1 - Date created - 1997-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A mathematical model for intracellular effects of toxins on DNA adduction and repair. AN - 78772487; 8980304 AB - The process by which certain classes of toxins compounds or their metabolites may react with DNA to alter the genetic information contained in subsequent generations of cells or organisms are a major component of hazard associated with exposure to chemicals in the environment. Many classes of chemicals may form DNA adducts and there may or may not be a defined mechanism to remove a particular adduct from DNA independent of replication. Many compounds and metabolites that bind DNA also readily bind existing proteins; some classes of toxins and DNA adducts have the capacity to inactivate a repair enzyme and divert the repair process competitively. This paper formulates an intracellular dynamic model for one aspect of the action of toxins that form DNA adducts, recognizing a capacity for removal of those adducts by a repair enzyme combined with reaction of the toxin and/or the DNA adduct to inactivate the repair enzyme. This paper model illustrates the possible saturation of repair enzyme capacity by the toxin dosage and shows that bistable behavior can occur, with the potential to induce abrupt shifts away from steady state equilibria. The model suggests that bistable behavior, dose and variation between individuals or tissues may combine under certain conditions to amplify the biological effect of dose observed as DNA adduction and its consequences as mutation. A model recognizing stochastic phenomena also indicates that variation in within-cell toxin concentration may promote jumps between stable equilibria. JF - Bulletin of mathematical biology AU - Gaver, D P AU - Jacobs, P A AU - Carpenter, R L AU - Burkhart, J G AD - Department of Operations Research, Naval Postgraduate School, Monterey, CA 93943, USA. Y1 - 1997/01// PY - 1997 DA - January 1997 SP - 89 EP - 106 VL - 59 IS - 1 SN - 0092-8240, 0092-8240 KW - DNA Adducts KW - 0 KW - Toxins, Biological KW - Index Medicus KW - DNA Damage KW - Stochastic Processes KW - Models, Biological KW - Mathematics KW - Toxins, Biological -- toxicity KW - DNA Adducts -- drug effects KW - DNA Repair -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78772487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+mathematical+biology&rft.atitle=A+mathematical+model+for+intracellular+effects+of+toxins+on+DNA+adduction+and+repair.&rft.au=Gaver%2C+D+P%3BJacobs%2C+P+A%3BCarpenter%2C+R+L%3BBurkhart%2C+J+G&rft.aulast=Gaver&rft.aufirst=D&rft.date=1997-01-01&rft.volume=59&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+mathematical+biology&rft.issn=00928240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-13 N1 - Date created - 1997-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preliminary observations of bedforms during SandyDuck AN - 742891190; 2010-033372 JF - Eos, Transactions, American Geophysical Union AU - Gallagher, Edith L AU - Anonymous Y1 - 1997 PY - 1997 DA - 1997 SP - 351 PB - American Geophysical Union, Washington, DC VL - 78 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - currents KW - sand KW - geophysical surveys KW - surf zones KW - clastic sediments KW - SandyDuck KW - geophysical methods KW - longshore currents KW - Duck North Carolina KW - Dare County North Carolina KW - ocean currents KW - bedforms KW - acoustical methods KW - marine sediments KW - North Carolina KW - sediments KW - surveys KW - coastal environment KW - ocean floors KW - 20:Applied geophysics KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742891190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Preliminary+observations+of+bedforms+during+SandyDuck&rft.au=Gallagher%2C+Edith+L%3BAnonymous&rft.aulast=Gallagher&rft.aufirst=Edith&rft.date=1997-01-01&rft.volume=78&rft.issue=46%2C+Suppl.&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1997 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - acoustical methods; bedforms; clastic sediments; coastal environment; currents; Dare County North Carolina; Duck North Carolina; geophysical methods; geophysical surveys; longshore currents; marine sediments; North Carolina; ocean currents; ocean floors; sand; SandyDuck; sediments; surf zones; surveys; United States ER - TY - JOUR T1 - Biodegradation of JP-8; effects of soil types and nutrients AN - 52465738; 1999-043695 JF - The Ohio Journal of Science AU - Bleckmann, C A AU - Baker, J A, III AU - Totten, C T AU - Hovey, P W AU - McGowin, A AU - Anonymous Y1 - 1997 PY - 1997 DA - 1997 SP - 34 PB - Ohio Academy of Science, Columbus, OH VL - 97 IS - 2 SN - 0030-0950, 0030-0950 KW - soils KW - biodegradation KW - oxygen KW - pollutants KW - pollution KW - effects KW - petroleum products KW - simulation KW - carbon dioxide KW - nutrients KW - clays KW - jet fuel KW - oil spills KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52465738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Ohio+Journal+of+Science&rft.atitle=Biodegradation+of+JP-8%3B+effects+of+soil+types+and+nutrients&rft.au=Bleckmann%2C+C+A%3BBaker%2C+J+A%2C+III%3BTotten%2C+C+T%3BHovey%2C+P+W%3BMcGowin%2C+A%3BAnonymous&rft.aulast=Bleckmann&rft.aufirst=C&rft.date=1997-01-01&rft.volume=97&rft.issue=2&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=The+Ohio+Journal+of+Science&rft.issn=00300950&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Ohio Academy of Science 106th annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - PubXState - OH N1 - Last updated - 2012-06-07 N1 - CODEN - OJSCA9 N1 - SubjectsTermNotLitGenreText - biodegradation; carbon dioxide; clays; effects; jet fuel; nutrients; oil spills; oxygen; petroleum products; pollutants; pollution; simulation; soils ER - TY - JOUR T1 - Full-scale demonstration of in situ aerobic cometabolism of trichloroethylene-contaminated groundwater AN - 52328769; 2000-057022 JF - Bioremediation AU - Goltz, Mark N AU - Hopkins, Gary D AU - Allan, Jason P AU - Dolan, Mark E AU - McCarty, Perry L AU - Alleman, Bruce C AU - Leeson, Andrea Y1 - 1997 PY - 1997 DA - 1997 SP - 71 PB - Battelle Press, Columbus, OH VL - 4, Vol. 3 KW - United States KW - chlorinated hydrocarbons KW - aquifer vulnerability KW - contaminant plumes KW - toluene KW - reclamation KW - observation wells KW - remediation KW - ground water KW - aerobic environment KW - California KW - solvents KW - halogenated hydrocarbons KW - biodegradation KW - in situ KW - bioreclamation KW - pollution KW - cometabolism KW - aquifers KW - organic compounds KW - Edwards Air Force Base KW - hydrocarbons KW - trichloroethylene KW - military facilities KW - aromatic hydrocarbons KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52328769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioremediation&rft.atitle=Full-scale+demonstration+of+in+situ+aerobic+cometabolism+of+trichloroethylene-contaminated+groundwater&rft.au=Goltz%2C+Mark+N%3BHopkins%2C+Gary+D%3BAllan%2C+Jason+P%3BDolan%2C+Mark+E%3BMcCarty%2C+Perry+L%3BAlleman%2C+Bruce+C%3BLeeson%2C+Andrea&rft.aulast=Goltz&rft.aufirst=Mark&rft.date=1997-01-01&rft.volume=4%2C+Vol.+3&rft.issue=&rft.spage=71&rft.isbn=1574770284&rft.btitle=&rft.title=Bioremediation&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fourth international symposium on In situ and on-site bioremediation N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - PubXState - OH N1 - Last updated - 2012-06-07 N1 - CODEN - #04467 N1 - SubjectsTermNotLitGenreText - aerobic environment; aquifer vulnerability; aquifers; aromatic hydrocarbons; biodegradation; bioreclamation; California; chlorinated hydrocarbons; cometabolism; contaminant plumes; Edwards Air Force Base; ground water; halogenated hydrocarbons; hydrocarbons; in situ; microorganisms; military facilities; observation wells; organic compounds; pollution; reclamation; remediation; solvents; toluene; trichloroethylene; United States ER - TY - JOUR T1 - The Entomophaga grylli (Fresenius) Batko species complex: Its biology, ecology, and use for biological control of pest grasshoppers AN - 17122525; 4430993 AB - The biology, ecology, disease etiology, and biological control potential of different members of the Entomophaga grylli species complex are discussed. This complex is represented by several pathotypes that include members that produce both conidia and resting spores within a single season, and members that produce only resting spores. This complex is known as a major pathogen of acridids from most areas of the world where populations of these insects are found, including Africa, Asia, Australia, Europe, North America, and South America. Pathogens from this species complex commonly cause disease epizootics in their host populations and are known to reduce significantly outbreaks of grasshoppers, particularly following periods of rain or high humidity. Specific factors that either limit or enhance disease processes and host mortality are discussed in relation to both epizootiology and biological control programmes. Recent biological control efforts are discussed and the potential of using members of the E. grylli species complex in both augmentation and introduction programmes is considered. JF - Memoirs of the Entomological Society of Canada AU - Carruthers, R I AU - Ramos, ME AU - Larkin, T S AU - Hostetter, D L AU - Soper, R S AD - USDA-ARS-NPS, Building 005, Room 220, Beltsville Agriculture Research Centre - West, Beltsville, Maryland, 20705 USA Y1 - 1997 PY - 1997 DA - 1997 SP - 329 EP - 353 VL - 171 SN - 0071-075X, 0071-075X KW - Benin KW - biological control KW - pathogenicity KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Entomology Abstracts KW - Acrididae KW - Orthoptera KW - Entomophaga grylli KW - A 01014:Others KW - Z 05207:Agricultural & general applied entomology KW - K 03092:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17122525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Memoirs+of+the+Entomological+Society+of+Canada&rft.atitle=The+Entomophaga+grylli+%28Fresenius%29+Batko+species+complex%3A+Its+biology%2C+ecology%2C+and+use+for+biological+control+of+pest+grasshoppers&rft.au=Carruthers%2C+R+I%3BRamos%2C+ME%3BLarkin%2C+T+S%3BHostetter%2C+D+L%3BSoper%2C+R+S&rft.aulast=Carruthers&rft.aufirst=R&rft.date=1997-01-01&rft.volume=171&rft.issue=&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Memoirs+of+the+Entomological+Society+of+Canada&rft.issn=0071075X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Acrididae; Entomophaga grylli; Orthoptera ER - TY - JOUR T1 - A Web-based decision support system for waste disposal and recycling AN - 16458824; 4357724 AB - Insufficient recycling of household and industrial waste in the U.S.A. has led to increased fullness and losses in landfills. Decision support systems (DSS) can encourage recycling, by giving consumers better access to information and decision models that maximize their economic incentives for recycling. This paper presents such a model (for optimizing delivery of waste to transfer stations) and describes its implementation in a DSS that is installed on a World Wide Web server and stores detailed data and the decision models. The model determines the transfer stations that are to be visited, items that are to be dropped at each station visited, and the travel route between stations, and makes the best tradeoff between the monetary pay off and travel times. DSS users access the system via standard Web browsers, and can query the database or use the decision models. Providers of recycling services can update, also using a Web browser, data about their site via hypertext mark-up language (HTML) forms. JF - COMPUT., ENVIRON. URBAN SYST. AU - Bhargava, H K AU - Tettelbach, C AD - Naval Postgraduate School, 589 Dyer Rd., Monterey, CA 93943-5100, USA, bhargava@nps.navy.mil Y1 - 1997/01// PY - 1997 DA - Jan 1997 SP - 47 EP - 65 VL - 21 IS - 1 SN - 0198-9715, 0198-9715 KW - Pollution Abstracts KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16458824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=COMPUT.%2C+ENVIRON.+URBAN+SYST.&rft.atitle=A+Web-based+decision+support+system+for+waste+disposal+and+recycling&rft.au=Bhargava%2C+H+K%3BTettelbach%2C+C&rft.aulast=Bhargava&rft.aufirst=H&rft.date=1997-01-01&rft.volume=21&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=COMPUT.%2C+ENVIRON.+URBAN+SYST.&rft.issn=01989715&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Screening technology trains for DNAPL remediation AN - 1524612193; 2014-031421 AB - The Department of Energy (DOE) is conducting a Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) mandated Remedial Investigation/Feasibility Study for a site contaminated with Dense Non-Aqueous Phase Liquid (DNAPL) pollutants. Three key efforts were a hydrogeological modeling approach, the generation of feasible sequences of technologies, and the screening of alternative technologies. This research uses a decision analysis process to provide a quantitative assessment of the candidate technologies. Decision analysis modeling was used to gain insight into each sequence of technologies. Sensitivity analysis was also conducted to assess the impact of key assumptions. The results provided the DOE with an objective and traceable rationale for screening and reducing all of the potential technology combinations to 58 technology combinations and a method for identifying the top scoring combinations. The approach has wide applicability to similar CERCLA remediation efforts. Abstract Copyright (1997), Wiley Periodicals, Inc., A Wiley Company. JF - Remediation (New York, NY) AU - Kloeber, Jack M, Jr AU - Papatyi, Anthony F AU - Deckro, Richard F AU - Parnell, Gregory S AU - Jackson, Jack A Y1 - 1997 PY - 1997 DA - 1997 SP - 87 EP - 105 PB - John Wiley & Sons, New York, NY VL - 8 IS - 1 SN - 1051-5658, 1051-5658 KW - United States KW - chlorinated hydrocarbons KW - aquifer vulnerability KW - technology KW - soil vapor extraction KW - dense nonaqueous phase liquids KW - remediation KW - ground water KW - sensitivity analysis KW - description KW - halogenated hydrocarbons KW - pump-and-treat KW - discharge KW - concentration KW - in situ KW - Superfund KW - pollutants KW - oxidation KW - pollution KW - Rocky Flats Plant KW - porous materials KW - decision-making KW - solubility KW - bioremediation KW - porosity KW - aquifers KW - nonaqueous phase liquids KW - organic compounds KW - permeable treatment zone KW - saturation KW - trichloroethylene KW - hydraulic conductivity KW - Colorado KW - permeability KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524612193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Remediation+%28New+York%2C+NY%29&rft.atitle=Screening+technology+trains+for+DNAPL+remediation&rft.au=Kloeber%2C+Jack+M%2C+Jr%3BPapatyi%2C+Anthony+F%3BDeckro%2C+Richard+F%3BParnell%2C+Gregory+S%3BJackson%2C+Jack+A&rft.aulast=Kloeber&rft.aufirst=Jack&rft.date=1997-01-01&rft.volume=8&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Remediation+%28New+York%2C+NY%29&rft.issn=10515658&rft_id=info:doi/10.1002%2Frem.3440080109 L2 - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291520-6831 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2014-01-01 N1 - Number of references - 22 N1 - PubXState - NY N1 - Document feature - illus. N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - aquifer vulnerability; aquifers; bioremediation; chlorinated hydrocarbons; Colorado; concentration; decision-making; dense nonaqueous phase liquids; description; discharge; ground water; halogenated hydrocarbons; hydraulic conductivity; in situ; nonaqueous phase liquids; organic compounds; oxidation; permeability; permeable treatment zone; pollutants; pollution; porosity; porous materials; pump-and-treat; remediation; Rocky Flats Plant; saturation; sensitivity analysis; soil vapor extraction; solubility; Superfund; technology; trichloroethylene; United States DO - http://dx.doi.org/10.1002/rem.3440080109 ER - TY - JOUR T1 - River basin management in the 21ST century: blending development with economic, ecologic, and cultural sustainability AN - 13624775; 199802067 AB - The benefits and drawbacks of the development of the world's rivers are noted, with the need for sustainable development to allow for future growth without further damage. Recent experiences with river development in the U.S.A. and elsewhere are reviewed. The need for sustainable water development is acknowledged world-wide but would require major efforts from all involved. There are 37 references. JF - Water International AU - Galloway, GE AD - National Defense University, Fort McNair, D.C., U.S.A. Y1 - 1997 PY - 1997 DA - 1997 SP - 82 EP - 89 VL - 22 IS - 2 SN - 0250-8060, 0250-8060 KW - Aqualine Abstracts KW - AQ 00001:Water Resources and Supplies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13624775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+International&rft.atitle=River+basin+management+in+the+21ST+century%3A+blending+development+with+economic%2C+ecologic%2C+and+cultural+sustainability&rft.au=Galloway%2C+GE&rft.aulast=Galloway&rft.aufirst=GE&rft.date=1997-01-01&rft.volume=22&rft.issue=2&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Water+International&rft.issn=02508060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Comparisons of time series from two global models with tide-gauge data AN - 1524399234; 19557029 AB - To understand climate change and to predict changes in climate, both atmospheric and ocean models need to be able to reproduce the responses of the system they are estimating. An evaluation of two related global ocean models, using a nine year time series of model sea surface heights and measurements of sea level from a global tide gauge set, shows that the ocean models satisfactorily reproduce the instantaneous local change in sea level. Sea level can be used as a tool to understand a model's ability to simulate sea surface temperature and thus influence atmospheric flows. The implication for climate modeling is that these ocean models can be used to simulate seasonal to decadal variations in global ocean circulation when coupled to high quality atmospheric models. JF - Geophysical Research Letters AU - Tokmakian, Robin AD - Dept. of Oceanography, Naval Postgraduate School, Monterey, CA. Y1 - 1996/12// PY - 1996 DA - December 1996 SP - 3759 EP - 3762 PB - American Geophysical Union, 2000 Florida Ave., N.W. Washington DC 20009 United States VL - 23 IS - 25 SN - 0094-8276, 0094-8276 KW - Meteorological & Geoastrophysical Abstracts; Sustainability Science Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Sea level KW - Atmospheric flows KW - Decadal variations KW - Ocean models KW - Climate change KW - Time series analysis KW - Atmospheric models KW - Sulfur dioxide KW - Air-sea coupling KW - Seasonal variations KW - Modelling KW - Temperature effects KW - Climate models KW - Temperature KW - Ocean circulation KW - Tides KW - Oceanic circulation KW - Atmosphere-ocean coupled models KW - Long-term changes KW - Tide gauges KW - Oceans KW - Sea level changes KW - O 2010:Physical Oceanography KW - M2 551.583:Variations (551.583) KW - M3 1010:Issues in Sustainable Development KW - Q2 09244:Air-sea coupling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524399234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=Comparisons+of+time+series+from+two+global+models+with+tide-gauge+data&rft.au=Tokmakian%2C+Robin&rft.aulast=Tokmakian&rft.aufirst=Robin&rft.date=1996-12-01&rft.volume=23&rft.issue=25&rft.spage=3759&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/10.1029%2F96GL03583 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Temperature effects; Air-sea coupling; Tide gauges; Long-term changes; Climate change; Ocean circulation; Modelling; Sea level changes; Oceanic circulation; Atmospheric flows; Atmosphere-ocean coupled models; Climate models; Decadal variations; Ocean models; Time series analysis; Atmospheric models; Sulfur dioxide; Sea level; Oceans; Temperature; Seasonal variations; Tides DO - http://dx.doi.org/10.1029/96GL03583 ER - TY - JOUR T1 - Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, a long-acting ester derivative of GBR 12909. AN - 78569211; 8941381 JF - Journal of medicinal chemistry AU - Glowa, J R AU - Fantegrossi, W E AU - Lewis, D B AU - Matecka, D AU - Rice, K C AU - Rothman, R B AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1996/11/22/ PY - 1996 DA - 1996 Nov 22 SP - 4689 EP - 4691 VL - 39 IS - 24 SN - 0022-2623, 0022-2623 KW - Decanoates KW - 0 KW - Dopamine Uptake Inhibitors KW - Piperazines KW - vanoxerine KW - 90X28IKH43 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Molecular Structure KW - Substance-Related Disorders -- therapy KW - Decanoates -- chemical synthesis KW - Behavior, Animal -- drug effects KW - Animals KW - Decanoates -- pharmacology KW - Macaca mulatta KW - Male KW - Piperazines -- chemical synthesis KW - Piperazines -- pharmacology KW - Cocaine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78569211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Sustained+decrease+in+cocaine-maintained+responding+in+rhesus+monkeys+with+1-%5B2-%5Bbis%284-fluorophenyl%29methoxy%5Dethyl%5D-4-%283-hydroxy-3-phenylpropyl%29+piperazinyl+decanoate%2C+a+long-acting+ester+derivative+of+GBR+12909.&rft.au=Glowa%2C+J+R%3BFantegrossi%2C+W+E%3BLewis%2C+D+B%3BMatecka%2C+D%3BRice%2C+K+C%3BRothman%2C+R+B&rft.aulast=Glowa&rft.aufirst=J&rft.date=1996-11-22&rft.volume=39&rft.issue=24&rft.spage=4689&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-06 N1 - Date created - 1997-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anesthetic drug interactions. AN - 78711273; 9077156 JF - CRNA : the clinical forum for nurse anesthetists AU - McAuliffe, M S AU - Hartshorn, E A AD - Uniformed Services University of The Health Sciences, Graduate School of Nursing Nurse Anesthesia Program, Bethesda, MD, USA. Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 216 EP - 218 VL - 7 IS - 4 SN - 1048-2687, 1048-2687 KW - Analgesics KW - 0 KW - Anesthetics KW - Neuromuscular Blocking Agents KW - Nursing KW - Neuromuscular Blocking Agents -- adverse effects KW - Drug Interactions KW - Humans KW - Analgesics -- adverse effects KW - Anesthetics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78711273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CRNA+%3A+the+clinical+forum+for+nurse+anesthetists&rft.atitle=Anesthetic+drug+interactions.&rft.au=McAuliffe%2C+M+S%3BHartshorn%2C+E+A&rft.aulast=McAuliffe&rft.aufirst=M&rft.date=1996-11-01&rft.volume=7&rft.issue=4&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=CRNA+%3A+the+clinical+forum+for+nurse+anesthetists&rft.issn=10482687&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-03 N1 - Date created - 1997-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Revolutionary Origins and Conditional Mobilization AN - 61471846; 9709963 AB - Expands previous research to examine popular expectations' role in political mobilization & the dilemma this poses for nascent revolutionary organizations. It is argued that, in any target population, there exists a small hardcore minority of unconditional supporters of each side. The majority of individuals can be influenced to support either side depending on their predictions of others' behavior & their estimates of each side's prospects. The conditional nature of such support poses an early mobilization problem for revolutionary challengers, who begin the struggle from a position of weakness. The expected returns to membership are quite low, & the costs of association are correspondingly high. Revolutionary groups attempt to overcome this challenge through the use of symbolic violence, which acts as a surrogate variable by would-be supporters to estimate the size & relative prospects of the armed opposition. This process can result in agent expectations become self-confirming, permitting the group to jump start the mobilization process & achieve a self-sustaining level of revolutionary activity. 5 Tables, 5 Figures, 1 Appendix, 25 References. Adapted from the source document. JF - European Journal of Political Economy AU - McCormick, Gordon H AU - Owen, Guillermo AD - Dept National Security Affairs Naval Postgraduate School, Monterey CA 93943 Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 377 EP - 402 VL - 12 IS - 3 SN - 0176-2680, 0176-2680 KW - revolutionary organizations, conditional political mobilization, symbolic violence usage KW - popular expectations KW - Political Movements KW - Revolutions KW - Membership KW - Mobilization KW - article KW - 0925: political sociology/interactions; sociology of political systems, politics, & power KW - 0826: mass phenomena; social movements UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61471846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Political+Economy&rft.atitle=Revolutionary+Origins+and+Conditional+Mobilization&rft.au=McCormick%2C+Gordon+H%3BOwen%2C+Guillermo&rft.aulast=McCormick&rft.aufirst=Gordon&rft.date=1996-11-01&rft.volume=12&rft.issue=3&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Political+Economy&rft.issn=01762680&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - EJECE3 N1 - SubjectsTermNotLitGenreText - Revolutions; Mobilization; Political Movements; Membership ER - TY - JOUR T1 - Northern Gorda Ridge intrusive/eruptive event; remote detections and directed rapid response posters AN - 52492934; 1999-017888 JF - Eos, Transactions, American Geophysical Union AU - Baker, E T AU - Massoth, G J AU - Lupton, J E AU - Walker, S L AU - Tennant, D A AU - Wilson, C AU - Garfield, N AU - Anonymous Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 1 PB - American Geophysical Union, Washington, DC VL - 77 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - East Pacific KW - plumes KW - Northeast Pacific KW - magmatism KW - Gorda Rise KW - depth KW - temperature KW - measurement KW - hydrothermal conditions KW - intrusions KW - thermal anomalies KW - seismicity KW - North Pacific KW - eruptions KW - Pacific Ocean KW - bathymetry KW - ocean floors KW - hydrophones KW - crust KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52492934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Northern+Gorda+Ridge+intrusive%2Feruptive+event%3B+remote+detections+and+directed+rapid+response+posters&rft.au=Baker%2C+E+T%3BMassoth%2C+G+J%3BLupton%2C+J+E%3BWalker%2C+S+L%3BTennant%2C+D+A%3BWilson%2C+C%3BGarfield%2C+N%3BAnonymous&rft.aulast=Baker&rft.aufirst=E&rft.date=1996-11-01&rft.volume=77&rft.issue=46%2C+Suppl.&rft.spage=F1&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1996 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - bathymetry; crust; depth; East Pacific; eruptions; Gorda Rise; hydrophones; hydrothermal conditions; intrusions; magmatism; measurement; North Pacific; Northeast Pacific; ocean floors; Pacific Ocean; plumes; seismicity; temperature; thermal anomalies ER - TY - JOUR T1 - Successful tracking of a hydrothermal event plume with a RAFOS neutrally-buoyant drifter AN - 52492563; 1999-017891 JF - Eos, Transactions, American Geophysical Union AU - Lupton, J E AU - Baker, E T AU - Garfield, N AU - Greene, R AU - Rago, T AU - Anonymous Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 1 PB - American Geophysical Union, Washington, DC VL - 77 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - East Pacific KW - plumes KW - Northeast Pacific KW - geophysical surveys KW - hydrothermal vents KW - satellite methods KW - Gorda Rise KW - hydrothermal conditions KW - detection KW - North Pacific KW - volcanism KW - marine environment KW - Pacific Ocean KW - surveys KW - bathymetry KW - ocean floors KW - remote sensing KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52492563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Successful+tracking+of+a+hydrothermal+event+plume+with+a+RAFOS+neutrally-buoyant+drifter&rft.au=Lupton%2C+J+E%3BBaker%2C+E+T%3BGarfield%2C+N%3BGreene%2C+R%3BRago%2C+T%3BAnonymous&rft.aulast=Lupton&rft.aufirst=J&rft.date=1996-11-01&rft.volume=77&rft.issue=46%2C+Suppl.&rft.spage=F1&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1996 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - bathymetry; detection; East Pacific; geophysical surveys; Gorda Rise; hydrothermal conditions; hydrothermal vents; marine environment; North Pacific; Northeast Pacific; ocean floors; Pacific Ocean; plumes; remote sensing; satellite methods; surveys; volcanism ER - TY - JOUR T1 - Effect of O side-chain length and composition on the virulence of Shigella flexneri 2a. AN - 78500744; 8899709 AB - IcsA of Shigella flexneri is required for intercellular spread and is located in the outer membrane at one pole of the bacterium, where it catalyses the polymerization of host-cell actin. The formation of the a tin tail provides the force to move the bacterium in a unidirectional manner through the host-cell cytoplasm. We have previously demonstrated that rough lipopolysaccharide (LPS) mutants of S. flexneri 2a are avirulent and cannot form plaques in tissue-culture monolayers. This inability to form plaques is associated with non-polar localization of IcsA and loss of host-cell membrane-protrusion formation ("fireworks'). To define the minimal LPS structure required for fireworks formation, we constructed a strain of S. flexneri (BS497) that contains a mutation in rfc, encoding the O side-chain polymerase, and a strain, BS520, that possesses a defective O side-chain ligase due to a mutation in rfaL. BS497 produces a LPS that consists of a core with one repeat unit of the O side-chain, while BS520 produces a LPS consisting of a complete core with no O side-chain. BS497 remained invasive but did not form fireworks or plaques in tissue-culture monolayers and was negative in the Serény test. BS520 was invasive, generated reduced numbers of short fireworks, and made tiny plaques, but it was negative in the Serény test. Analysis of BS497 with anti-IcsA antibody demonstrated that IcsA was distributed over the entire cell surface. The distribution of IcsA on the surface of BS520 was predominantly unipolar, with some trail-back of IcsA label along the sides of the bacterium. A similar pattern was seen when infected monolayers were stained for polymerized actin. These results suggest that both the presence and the length of the O side-chain are important in the proper localization or maintenance of IcsA at the pole which subsequently affects the ability to form actin tails and produce fireworks. This reduced ability to form actin tails and fireworks results in a decreased ability of Shigella to move into adjacent host cells. To determine if the sugar composition of the O side-chain is important in the ability to form fireworks, the rfb region of S. flexneri 2a was replaced with the rfb region from Escherichia coli serotype O8 or O25. Both hybrids were invasive, formed plaques, and gave positive Serény reactions. These results suggest that, unlike LPS length, the sugar composition of the O side-chain is not a critical requirement for the proper localization of IcsA and efficient intercellular movement. JF - Molecular microbiology AU - Sandlin, R C AU - Goldberg, M B AU - Maurelli, A T AD - Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1996/10// PY - 1996 DA - October 1996 SP - 63 EP - 73 VL - 22 IS - 1 SN - 0950-382X, 0950-382X KW - Actins KW - 0 KW - Bacterial Proteins KW - DNA-Binding Proteins KW - Escherichia coli Proteins KW - Membrane Proteins KW - O Antigens KW - RfaL protein, E coli KW - Transcription Factors KW - virG protein, Shigella flexneri KW - Hexosyltransferases KW - EC 2.4.1.- KW - O-antigen polymerase KW - Ligases KW - EC 6.- KW - Index Medicus KW - Ligases -- genetics KW - Animals KW - L Cells (Cell Line) KW - Bacterial Proteins -- genetics KW - HeLa Cells KW - Humans KW - Actins -- metabolism KW - Mice KW - Phenotype KW - Transcription Factors -- isolation & purification KW - Carbohydrate Sequence KW - Molecular Sequence Data KW - DNA-Binding Proteins -- isolation & purification KW - Mutation KW - Mutagenesis, Insertional KW - Hexosyltransferases -- genetics KW - Shigella flexneri -- pathogenicity KW - Shigella flexneri -- cytology KW - Shigella flexneri -- genetics KW - O Antigens -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78500744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Effect+of+O+side-chain+length+and+composition+on+the+virulence+of+Shigella+flexneri+2a.&rft.au=Sandlin%2C+R+C%3BGoldberg%2C+M+B%3BMaurelli%2C+A+T&rft.aulast=Sandlin&rft.aufirst=R&rft.date=1996-10-01&rft.volume=22&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-19 N1 - Date created - 1997-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gastroenterology workforce modeling. AN - 85226278; pmid-8769546 AB - OBJECTIVE: To examine the current supply and distribution of gastroenterologists and project future supply under various scenarios to provide a paradigm for workforce reform. DESIGN: An analysis of current practices and distribution of gastroenterologists and a demographic model, using the 1992 gastroenterology workforce as a baseline. MAIN OUTCOME MEASURE: Comparison of current supply, distribution, and practice profiles with past data and future projections, using analyses of data from the 1993 Area Resource File, 1992 Medicare Part B file, age- and sex-specific death and retirement rates from the Bureau of Health Professions, managed care staffing patterns, the National Survey of Internal Medicine Manpower, and the Bureau of the Census. RESULTS: Rapid growth in the number of US gastroenterologists has resulted in a gastroenterologist-to-population ratio double that used on average by health maintenance organizations. In addition, the work profile of gastroenterologists is shared significantly by primary care physicians and other specialists, with the exception of a few specific and uncommon procedures. CONCLUSIONS: Empirical evidence suggests that, even in the absence of detailed models to describe the desired supply/need balance for gastroenterology, the US health care system and clinicians may benefit from a reduction in gastroenterology training programs. The Gastroenterology Leadership Council endorsed a goal of 25% to 50% reduction in trainee numbers over 5 years, and recent National Resident Matching Program data indicate that a voluntary downsizing process is in full force. This study illustrates a paradigm for workforce planning that could be useful for other medical specialties. JF - JAMA AU - Meyer, G S AU - Jacoby, I AU - Krakauer, H AU - Powell, D W AU - Aurand, J AU - McCardle, P AD - Division of Health Services Administration, Center for Health Care Quality Assessment, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4999, USA. PY - 1996 SP - 689 EP - 694 VL - 276 IS - 9 SN - 0098-7484, 0098-7484 KW - Demography KW - Education, Medical KW - United States KW - Health Care Reform KW - Support, Non-U.S. Gov't KW - Forecasting KW - Models, Statistical KW - Physicians KW - Gastroenterology KW - Health Manpower UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Gastroenterology+workforce+modeling.&rft.au=Meyer%2C+G+S%3BJacoby%2C+I%3BKrakauer%2C+H%3BPowell%2C+D+W%3BAurand%2C+J%3BMcCardle%2C+P&rft.aulast=Meyer&rft.aufirst=G&rft.date=1996-09-01&rft.volume=276&rft.issue=9&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mechanism of enhancement of the antiviral action of interferon against herpes simplex virus-1 by chloroquine. AN - 78474003; 8887057 AB - Using double immunofluorescence, we have shown previously that interferon (IFN) treatment inhibits the transport of herpes simplex virus-1 (HSV-1) gD from the Golgi complex to the plasma membrane in the virus infected and gD cDNA transfected LMtk-cells. In the present study, we quantitated the gD protein on the cell surface and localized the gD protein in the trans-Golgi network (TGN). The results showed 10-fold less fluorescence for the gD protein on the cell surface in IFN-treated LMtk-cells. Subcellular fractionation studies demonstrated that gD was associated with TGN-enriched membranes. Gold labeling for DAMP distribution using electron microscopy showed that IFN raised the pH of TGN. IFNs induced alkalinization of TGN may be related to the block in the transport of HSV-1 gD. Earlier we reported that a subeffective dose of chloroquine (CHL) or IFN does not change the pHi. However, both CHL and IFN together raise the pHi significantly. To study the biologic significance of the finding, the effect of these subeffective doses of IFN and CHL on the antiviral activity and the transport of the gD protein was studied. Results suggested that CHL enhance the antiviral activity of IFN against HSV-1 and concomitantly increase the inhibition of HSV-1 gD transport. This IFN-induced increase in pHi of the TGN may also explain the inhibitory effect of IFN reported on the terminal steps of some of the enveloped viruses. JF - Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research AU - Singh, A K AU - Sidhu, G S AU - Friedman, R M AU - Maheshwari, R K AD - Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Y1 - 1996/09// PY - 1996 DA - September 1996 SP - 725 EP - 731 VL - 16 IS - 9 SN - 1079-9907, 1079-9907 KW - Antiviral Agents KW - 0 KW - Recombinant Proteins KW - Viral Envelope Proteins KW - glycoprotein E, herpes simplex virus type 1 KW - Interferon-beta KW - 77238-31-4 KW - Chloroquine KW - 886U3H6UFF KW - Index Medicus KW - Animals KW - Reference Values KW - Recombinant Proteins -- pharmacology KW - Microscopy, Electron KW - Mice KW - Flow Cytometry KW - Subcellular Fractions -- metabolism KW - Drug Synergism KW - Immunohistochemistry KW - Cell Line KW - Biological Transport -- drug effects KW - Interferon-beta -- pharmacology KW - Chloroquine -- pharmacology KW - Antiviral Agents -- pharmacology KW - Viral Envelope Proteins -- biosynthesis KW - Herpesvirus 1, Human -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78474003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+interferon+%26+cytokine+research+%3A+the+official+journal+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=Mechanism+of+enhancement+of+the+antiviral+action+of+interferon+against+herpes+simplex+virus-1+by+chloroquine.&rft.au=Singh%2C+A+K%3BSidhu%2C+G+S%3BFriedman%2C+R+M%3BMaheshwari%2C+R+K&rft.aulast=Singh&rft.aufirst=A&rft.date=1996-09-01&rft.volume=16&rft.issue=9&rft.spage=725&rft.isbn=&rft.btitle=&rft.title=Journal+of+interferon+%26+cytokine+research+%3A+the+official+journal+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=10799907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-19 N1 - Date created - 1997-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of substance P release from the intermediate area of rat thoracic spinal cord. AN - 78414086; 8855511 AB - Substance P (SP) nerve terminals innervate the intermediolateral cell column (IML) of the thoracic spinal cord, where SP coexists with serotonin (5-HT), neurokinin A (NKA) and thyrotropin-releasing hormone (TRH). Neither the depolarization-induced release of SP nor the presence of other neurochemicals in the regulation of SP release has been directly studied in this system. In the present study, basal and K(+)-stimulated release of SP from the microdissected intermediate area (including the IML, intercalated nucleus and central autonomic nucleus) of the rat thoracic spinal cord, and the regulation of SP release by presynaptic autoreceptors and by coexisting neurochemicals (5-HT, NKA and TRH) were studied using an in vitro superfusion system. Potassium evoked a concentration- and extracellular Ca(2+)-dependent release of SP. In rats pretreated with the serotoninergic neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT), both SP content and the absolute amount of SP released were decreased. However, the fraction of the remaining tissue content of SP released by K+ depolarization was not changed subsequent to 5,7-DHT treatment. Moreover, 5-HT, 5-HT1B agonists (CGS-12066B and RU 24969) and a 5-HT3 agonist (2-methyl-5-HT) did not alter the K(+)-evoked release of SP. These data demonstrate that SP is released from the intermediate area of the rat thoracic spinal cord and some of the SP released comes from serotoninergic nerve terminals. Although 5-HT coexists with SP in the IML, neither endogenous 5-HT nor 5-HT receptor ligands appear to regulate the release of SP. Other colocalized neuropeptides (NKA and TRH) are not involved in the regulation of SP release because neither NKA, a NK2 agonist (GR 64349) nor a TRH analog (MK-771) changed the K(+)-evoked release of SP. A neurokinin-1 (NK1) antagonist (GR 82334) dose-dependently (10(-9)-10(-7) M) increased the K(+)-stimulated release of SP. These data suggest the presence of presynaptic inhibitory NK1 autoreceptors. Whereas, NK1 agonists, [GR 73632 (10(-9)-10(-6) M) and [Sar9, Met (O2)11]SP (10(-8)-10(-6) M)], increased the basal and K(+)-stimulated release of SP, the excitatory effects of GR 73632 were not blocked by the NK1 antagonist. Moreover, GR 73632 increased the efflus of SP to a greater extent in the absence of peptidase inhibitors. Thus, the effect of NK1 agonists on the release of SP may be related to an inhibition of peptide degradation rather than activation of NK1 autoreceptors. JF - Synapse (New York, N.Y.) AU - Yang, L AU - Thomas, N D AU - Helke, C J AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1996/08// PY - 1996 DA - August 1996 SP - 265 EP - 273 VL - 23 IS - 4 SN - 0887-4476, 0887-4476 KW - Neurotoxins KW - 0 KW - Serotonin Agents KW - 5,7-Dihydroxytryptamine KW - 31363-74-3 KW - Serotonin KW - 333DO1RDJY KW - Substance P KW - 33507-63-0 KW - Thyrotropin-Releasing Hormone KW - 5Y5F15120W KW - Neurokinin A KW - 86933-74-6 KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Animals KW - Rats KW - Thyrotropin-Releasing Hormone -- pharmacology KW - Neurokinin A -- agonists KW - Rats, Sprague-Dawley KW - Neurokinin A -- pharmacology KW - Neurokinin A -- antagonists & inhibitors KW - Thorax KW - Potassium -- pharmacology KW - Male KW - Nerve Endings -- metabolism KW - Serotonin -- pharmacology KW - Spinal Cord -- metabolism KW - Serotonin -- physiology KW - Autonomic Fibers, Preganglionic -- metabolism KW - Spinal Cord -- drug effects KW - Substance P -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78414086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Characterization+of+substance+P+release+from+the+intermediate+area+of+rat+thoracic+spinal+cord.&rft.au=Yang%2C+L%3BThomas%2C+N+D%3BHelke%2C+C+J&rft.aulast=Yang&rft.aufirst=L&rft.date=1996-08-01&rft.volume=23&rft.issue=4&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-07 N1 - Date created - 1997-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An alternative pathway of recombination of chromosomal fragments precedes recA-dependent recombination in the radioresistant bacterium Deinococcus radiodurans. AN - 78249150; 8755873 AB - Deinococcus radiodurans R1 and other members of this genus are able to repair and survive extreme DNA damage induced by ionizing radiation and many other DNA-damaging agents. The ability of R1 to repair completely > 100 double-strand breaks in its chromosome without lethality or mutagenesis is recA dependent. However, during the first 1.5 h after irradiation, recA+ and recA cells show similar increases in the average size of chromosomal fragments. In recA+ cells, DNA continues to enlarge to wild-type size within 29 h. However, in recA cells, no DNA repair is observed following the first 1.5 h postirradiation. This recA-independent effect was studied further, using two slightly different Escherichia coli plasmids forming adjacent duplication insertions in the chromosome, providing repetitive sequences suitable for circularization by non-recA-dependent pathways following irradiation. After exposure to 1.75 Mrad (17,500 Gy), circular derivatives of the integration units were detected in both recA+ and recA cells. These DNA circles were formed in the first 1.5 h postirradiation, several hours before the onset of detectable recA-dependent homologous recombination. By comparison, D. radiodurans strains containing the same E. coli plasmids as nonrepetitive direct insertions did not form circular derivatives of the integration units before or after irradiation in recA+ or recA cells. The circular derivatives of the tandemly integrated plasmids were formed before the onset of recA-dependent repair and have structures consistent with the hypothesis that DNA repair occurring immediately postirradiation is by a recA-independent single-strand annealing reaction and may be a preparatory step for further DNA repair in wild-type D. radiodurans. JF - Journal of bacteriology AU - Daly, M J AU - Minton, K W AD - F.E. Hébert Medical School, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1996/08// PY - 1996 DA - August 1996 SP - 4461 EP - 4471 VL - 178 IS - 15 SN - 0021-9193, 0021-9193 KW - DNA, Bacterial KW - 0 KW - Rec A Recombinases KW - EC 2.7.7.- KW - Index Medicus KW - DNA Repair -- genetics KW - Genes, Bacterial KW - Alleles KW - Polymorphism, Genetic KW - DNA Damage KW - DNA, Bacterial -- genetics KW - Escherichia coli -- genetics KW - DNA, Bacterial -- metabolism KW - Chromosome Mapping KW - Radiation Tolerance -- genetics KW - DNA, Bacterial -- radiation effects KW - Chromosomes, Bacterial -- radiation effects KW - Rec A Recombinases -- genetics KW - Micrococcus -- metabolism KW - Recombination, Genetic KW - Micrococcus -- radiation effects KW - Chromosomes, Bacterial -- genetics KW - Micrococcus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78249150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=An+alternative+pathway+of+recombination+of+chromosomal+fragments+precedes+recA-dependent+recombination+in+the+radioresistant+bacterium+Deinococcus+radiodurans.&rft.au=Daly%2C+M+J%3BMinton%2C+K+W&rft.aulast=Daly&rft.aufirst=M&rft.date=1996-08-01&rft.volume=178&rft.issue=15&rft.spage=4461&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-09-26 N1 - Date created - 1996-09-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 1975 Feb;121(2):422-8 [1112771] J Bacteriol. 1996 Jan;178(1):130-5 [8550406] J Theor Biol. 1978 Apr 6;71(3):339-46 [642534] J Bacteriol. 1978 Apr;134(1):71-5 [649572] J Mol Biol. 1983 Jul 5;167(3):539-60 [6308264] Gene. 1984 Feb;27(2):151-60 [6327464] Cell. 1983 May;33(1):25-35 [6380756] J Bacteriol. 1988 May;170(5):2126-35 [2834326] Nucleic Acids Res. 1988 Jul 11;16(13):6015-25 [2840639] Plasmid. 1989 Sep;22(2):132-42 [2695951] J Bacteriol. 1990 Jun;172(6):2955-61 [2160933] Gene. 1991 Feb 1;98(1):45-52 [1849496] Mutat Res. 1991 May;254(3):207-15 [1711150] J Bacteriol. 1991 Oct;173(19):6110-7 [1655698] Curr Opin Cell Biol. 1992 Jun;4(3):401-12 [1323316] Science. 1992 Oct 16;258(5081):480-4 [1411547] Plasmid. 1992 Nov;28(3):258-61 [1461940] Genetics. 1993 Mar;133(3):439-48 [8384141] Mutat Res. 1994 Jan;314(1):87-97 [7504195] Gene. 1994 Apr 8;141(1):31-7 [8163172] Radiat Res. 1994 May;138(2):282-5 [8183999] J Bacteriol. 1994 Jun;176(12):3508-17 [8206827] Mol Microbiol. 1994 Jul;13(1):9-15 [7984097] J Bacteriol. 1994 Dec;176(24):7506-15 [8002574] J Bacteriol. 1995 Apr;177(7):1692-8 [7896689] Bioessays. 1995 Jan;17(1):63-70 [7702595] Bioessays. 1995 May;17(5):457-64 [7786292] J Bacteriol. 1995 Oct;177(19):5495-505 [7559335] Science. 1995 Nov 24;270(5240):1318 [7481818] Mutat Res. 1976 Feb;34(2):175-86 [765808] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of halothane and isoflurane on carbon monoxide-induced relaxations in the rat aorta. AN - 78210550; 8712451 AB - Halothane and isoflurane previously were reported to attenuate endothelium-derived relaxing factor/nitric oxide-mediated vasodilation and cyclic guanosine monophosphate (cGMP) formation in isolated rat aortic rings. Carbon monoxide has many chemical and physiologic similarities to nitric oxide. This study was designed to investigate the effects of halothane and isoflurane on carbon monoxide-induced relaxations and cGMP formation in the isolated rat aorta. Isometric tension was recorded continuously from endothelium denuded rat aortic rings suspended in Krebs-filled organ baths. Rings precontracted with submaximal concentrations of norepinephrine were exposed to cumulative concentrations of carbon monoxide (26-176 microM). This procedure was repeated three times, with anesthetics delivered 10 min before the second procedure. Carbon monoxide responses of rings contracted with the same concentration of norepinephrine (10(-6) M and 2 x 10(-6) M) used in the anesthetic-exposed preparations also were examined. The concentrations of cGMP were determined in denuded rings using radioimmunoassay. The rings were treated with carbon monoxide (176 microM, 30 s) alone, or carbon monoxide after a 10-min incubation with halothane (0.34 mM or 0.72 mM). To determine whether the sequence of anesthetic delivery influenced results, vascular rings pretreated with halothane were compared with nonpretreated rings. Carbon monoxide (26-176 microM) caused a dose-dependent reduction of norepinephrine-induced tension, with a maximal relaxation of 1.51 +/- 0.07 g (85 +/- 7% of norepinephrine-induced contraction). Halothane (0.34 mM and 0.72 mM) significantly attenuated the carbon monoxide-induced relaxations, but only the highest concentration of isoflurane (0.53 mM) significantly attenuated the carbon monoxide-induced relaxations. Carbon monoxide (176 microM) significantly increased cGMP content (+88.1 +/- 7.1%) and preincubation of the aortic rings with halothane (0.34 mM and 0.72 mM) inhibited this increase (-70.7 +/- 6.8% and -108.1 +/- 10.6%, respectively). When aortic rings and carbon monoxide were added simultaneously to Krebs solution equilibrated with halothane (0.72 mM), no inhibition of cGMP formation occurred. Carbon monoxide-induced endothelium-independent relaxations of rat aortic rings were decreased by clinically relevant concentrations of halothane and isoflurane. The carbon monoxide-induced elevations of cGMP were attenuated by halothane only when the anesthetic was incubated with aortic rings before carbon monoxide treatment. The possible clinical significance of the actions of the anesthetics on this endogenous vasodilator is yet to be determined. JF - Anesthesiology AU - Jing, M AU - Bina, S AU - Verma, A AU - Hart, J L AU - Muldoon, S M AD - Department of Anesthesiology, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland 20814-4799, USA. Y1 - 1996/08// PY - 1996 DA - August 1996 SP - 347 EP - 354 VL - 85 IS - 2 SN - 0003-3022, 0003-3022 KW - Anesthetics, Inhalation KW - 0 KW - Vasoconstrictor Agents KW - Carbon Dioxide KW - 142M471B3J KW - Heme KW - 42VZT0U6YR KW - Isoflurane KW - CYS9AKD70P KW - Cyclic GMP KW - H2D2X058MU KW - Halothane KW - UQT9G45D1P KW - Norepinephrine KW - X4W3ENH1CV KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Vasoconstrictor Agents -- pharmacology KW - Drug Interactions KW - Norepinephrine -- pharmacology KW - Aorta, Thoracic -- metabolism KW - Binding Sites KW - Endothelium, Vascular -- physiology KW - Rats KW - Rats, Sprague-Dawley KW - Aorta, Thoracic -- drug effects KW - In Vitro Techniques KW - Isometric Contraction -- drug effects KW - Cyclic GMP -- biosynthesis KW - Heme -- metabolism KW - Male KW - Halothane -- pharmacology KW - Anesthetics, Inhalation -- pharmacology KW - Muscle, Smooth, Vascular -- drug effects KW - Muscle Relaxation -- drug effects KW - Muscle, Smooth, Vascular -- metabolism KW - Isoflurane -- pharmacology KW - Carbon Dioxide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78210550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Effects+of+halothane+and+isoflurane+on+carbon+monoxide-induced+relaxations+in+the+rat+aorta.&rft.au=Jing%2C+M%3BBina%2C+S%3BVerma%2C+A%3BHart%2C+J+L%3BMuldoon%2C+S+M&rft.aulast=Jing&rft.aufirst=M&rft.date=1996-08-01&rft.volume=85&rft.issue=2&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-09-12 N1 - Date created - 1996-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Organizational Construction of Hegemonic Masculinity: The Case of the US Navy AN - 61460968; 9709709 AB - Examines the construction of hegemonic masculinity in the US Navy, drawing on life-history interviews with 27 male officers to explore alternative discourses & identities of officers from the aviation, surface warfare, & supply corps communities. Definitions of masculinity are relationally constructed through associations of difference: aviators tend to draw on themes of autonomy & risk taking; surface warfare officers draw on themes of perseverance & endurance; & supply officers draw on themes of technical rationality. Further, these masculinities depend on various contrasting definitions of femininity. A series of contradictions that threaten the secure construction of masculinity in this military culture are considered. 46 References. Adapted from the source document. JF - Gender, Work and Organization AU - Barrett, Frank J AD - Dept Systems Management Naval Postgraduate School, Monterey CA 93940 Y1 - 1996/07// PY - 1996 DA - July 1996 SP - 129 EP - 142 VL - 3 IS - 3 SN - 0968-6673, 0968-6673 KW - hegemonic masculinity, organizational construction, US Navy, alternative discourses/identities KW - interviews KW - aviation/surface warfare/supply corps officers KW - Masculinity KW - Hegemony KW - Sex Role Identity KW - Organizational Culture KW - Military Officers KW - United States of America KW - Discourse KW - Ideologies KW - Social Constructionism KW - Armed Forces KW - article KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61460968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gender%2C+Work+and+Organization&rft.atitle=The+Organizational+Construction+of+Hegemonic+Masculinity%3A+The+Case+of+the+US+Navy&rft.au=Barrett%2C+Frank+J&rft.aulast=Barrett&rft.aufirst=Frank&rft.date=1996-07-01&rft.volume=3&rft.issue=3&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Gender%2C+Work+and+Organization&rft.issn=09686673&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - GWORF8 N1 - SubjectsTermNotLitGenreText - Armed Forces; Military Officers; Masculinity; Organizational Culture; Social Constructionism; Ideologies; Hegemony; Discourse; Sex Role Identity; United States of America ER - TY - JOUR T1 - Actinomycosis of the paranasal sinuses: a case report and review. AN - 85204506; pmid-8643310 JF - Otolaryngology--Head and Neck Surgery AU - Roth, M AU - Montone, K T AD - Uniformed Services University of the Health Sciences, USA. PY - 1996 SP - 818 EP - 821 VL - 114 IS - 6 SN - 0194-5998, 0194-5998 KW - Dental Implants KW - Penicillins KW - Actinomycosis KW - Human KW - Adult KW - Maxillary Sinusitis KW - Case Report KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85204506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Actinomycosis+of+the+paranasal+sinuses%3A+a+case+report+and+review.&rft.au=Roth%2C+M%3BMontone%2C+K+T&rft.aulast=Roth&rft.aufirst=M&rft.date=1996-06-01&rft.volume=114&rft.issue=6&rft.spage=818&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study. AN - 78234344; 8727138 AB - Polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (poly-ICLC) (10-50 mcg/kg, administered intramuscularly one to three times weekly) was given for < or = 56 months to 38 patients with malignant gliomas. There was minimal or no toxicity. Twenty of 30 patients (66%) receiving at least twice weekly poly-ICLC showed regression or stabilization of gadolinium-enhancing tumor, as revealed by magnetic resonance imaging (median = 65% volume decrease). All but one patient with anaplastic astrocytomas who received continuous poly-ICLC remain alive, with a median progression-free survival of 54 months from diagnosis. Median Kaplan-Meier survival is 19 months for patients with glioblastomas who receive at least twice weekly poly-ICLC treatments. Tumor response was associated with 2',5' -oligoadenylate synthetase activation (P = 0.03) but not with serum interferon. We hypothesize clinical activation by poly-ICLC of a basic host tumor suppressor system. Prolonged, quality survival with tumor stabilization or regression confirmed by magnetic resonance imaging for most patients with anaplastic astrocytomas and glioblastomas suggests that more extensive laboratory and controlled clinical studies are warranted. The concept of long-term, broad spectrum stimulation of host defenses with nontoxic, inexpensive double-stranded ribonucleic acids, such as low-dose poly-ICLC, may be applicable to the treatment of other malignancies. JF - Neurosurgery AU - Salazar, A M AU - Levy, H B AU - Ondra, S AU - Kende, M AU - Scherokman, B AU - Brown, D AU - Mena, H AU - Martin, N AU - Schwab, K AU - Donovan, D AU - Dougherty, D AU - Pulliam, M AU - Ippolito, M AU - Graves, M AU - Brown, H AU - Ommaya, A AD - Uniformed Services University of the Health Sciences, Washington, District of Columbia, USA. Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 1096 EP - 103; discussion 1103-4 VL - 38 IS - 6 SN - 0148-396X, 0148-396X KW - Interferon Inducers KW - 0 KW - Poly I-C KW - 24939-03-5 KW - Polylysine KW - 25104-18-1 KW - Carboxymethylcellulose Sodium KW - K679OBS311 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Drug Administration Schedule KW - Polylysine -- administration & dosage KW - Dose-Response Relationship, Drug KW - Humans KW - Carboxymethylcellulose Sodium -- administration & dosage KW - Aged KW - Pilot Projects KW - Carboxymethylcellulose Sodium -- adverse effects KW - Survival Rate KW - Polylysine -- adverse effects KW - Adult KW - Neoplasm Recurrence, Local -- therapy KW - Middle Aged KW - Follow-Up Studies KW - Chemotherapy, Adjuvant KW - Female KW - Male KW - Neoplasm Recurrence, Local -- pathology KW - Brain Neoplasms -- pathology KW - Astrocytoma -- mortality KW - Brain Neoplasms -- therapy KW - Glioblastoma -- mortality KW - Brain Neoplasms -- mortality KW - Poly I-C -- administration & dosage KW - Glioblastoma -- pathology KW - Astrocytoma -- pathology KW - Interferon Inducers -- administration & dosage KW - Interferon Inducers -- adverse effects KW - Poly I-C -- adverse effects KW - Glioblastoma -- therapy KW - Astrocytoma -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78234344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurosurgery&rft.atitle=Long-term+treatment+of+malignant+gliomas+with+intramuscularly+administered+polyinosinic-polycytidylic+acid+stabilized+with+polylysine+and+carboxymethylcellulose%3A+an+open+pilot+study.&rft.au=Salazar%2C+A+M%3BLevy%2C+H+B%3BOndra%2C+S%3BKende%2C+M%3BScherokman%2C+B%3BBrown%2C+D%3BMena%2C+H%3BMartin%2C+N%3BSchwab%2C+K%3BDonovan%2C+D%3BDougherty%2C+D%3BPulliam%2C+M%3BIppolito%2C+M%3BGraves%2C+M%3BBrown%2C+H%3BOmmaya%2C+A&rft.aulast=Salazar&rft.aufirst=A&rft.date=1996-06-01&rft.volume=38&rft.issue=6&rft.spage=1096&rft.isbn=&rft.btitle=&rft.title=Neurosurgery&rft.issn=0148396X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-10-24 N1 - Date created - 1996-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of enclomiphene and zuclomiphene on basal and gonadotrophin-stimulated progesterone secretion by isolated subpopulations of small and large ovine luteal cells. AN - 78208690; 8671435 AB - We examined the effects of enclomiphene and zuclomiphene, alone and in combination with oestradiol, on basal and gonadotrophin-stimulated progesterone secretion by isolated subpopulations of both large (granulosa-lutein) and small (theca-lutein) ovine luteal cells. Isolated large and small luteal cells derived from intact, enucleated ovine corpora lutea were incubated for 48-120 h with or without 22R-hydroxycholesterol or pregnenolone (2.5 microM) and a range of enclomiphene, zuclomiphene, and/or oestradiol concentrations (3-100 microM), both with and without ovine luteinizing hormone (100 ng/ml). Spent media were assayed in duplicate for progesterone content by radioimmunoassay. Enclomiphene, zuclomiphene, and oestradiol exhibited equivalent dose-dependent inhibitory effects on basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion under all substrate conditions. Both cell types became more sensitive to clomiphene inhibition with increasing time in culture. In combined treatments, the effects of oestradiol and either enclomiphene or zuclomiphene became additive in longer-term cultures and were never antagonistic. In this model system, (i) clomiphene, like oestradiol, appears to inhibit 3beta-hydroxysteroid dehydrogenase activity, (ii) both stereoisomers act as oestrogen agonists, (iii) neither demonstrates any anti-oestrogenic properties, and (iv) both large and small luteal cells become more sensitive to clomiphene inhibition with increasing duration of exposure. JF - Human reproduction (Oxford, England) AU - Opsahl, M S AU - Fitz, T A AU - Rexroad, C E AU - Fritz, M A AD - National Naval Medical Center and Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 1250 EP - 1255 VL - 11 IS - 6 SN - 0268-1161, 0268-1161 KW - Fertility Agents, Female KW - 0 KW - Clomiphene KW - 1HRS458QU2 KW - Progesterone KW - 4G7DS2Q64Y KW - Estradiol KW - 4TI98Z838E KW - Pregnenolone KW - 73R90F7MQ8 KW - Luteinizing Hormone KW - 9002-67-9 KW - Enclomiphene KW - R6D2UI4FLS KW - Index Medicus KW - Animals KW - Drug Interactions KW - Pregnenolone -- metabolism KW - Dose-Response Relationship, Drug KW - Sheep KW - Luteinizing Hormone -- pharmacology KW - In Vitro Techniques KW - Estradiol -- pharmacology KW - Female KW - Corpus Luteum -- cytology KW - Clomiphene -- pharmacology KW - Corpus Luteum -- secretion KW - Corpus Luteum -- drug effects KW - Progesterone -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78208690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+reproduction+%28Oxford%2C+England%29&rft.atitle=Effects+of+enclomiphene+and+zuclomiphene+on+basal+and+gonadotrophin-stimulated+progesterone+secretion+by+isolated+subpopulations+of+small+and+large+ovine+luteal+cells.&rft.au=Opsahl%2C+M+S%3BFitz%2C+T+A%3BRexroad%2C+C+E%3BFritz%2C+M+A&rft.aulast=Opsahl&rft.aufirst=M&rft.date=1996-06-01&rft.volume=11&rft.issue=6&rft.spage=1250&rft.isbn=&rft.btitle=&rft.title=Human+reproduction+%28Oxford%2C+England%29&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-10-10 N1 - Date created - 1996-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Repair of ionizing-radiation damage in the radiation resistant bacterium Deinococcus radiodurans. AN - 78040926; 8632774 AB - Deinococcus radiodurans is extremely resistant to the lethal and mutagenic effects of ionizing-radiation and many other physical and chemical agents that damage DNA. This resistance is known to be due to D. radiodurans' extremely proficient DNA repair processes. However, little is known about the precise mechanisms employed by this organism to achieve its efficient repair. In the past two years there has been substantial progress in studies on the repair and tolerance of ionizing radiation damage. Areas of progress include: 1) studies on the importance of the deinococcal recA-gene in repair; 2) characterization of a large number of new ionizing radiation-sensitive strains; 3) newly discovered genetic loci with novel repair-related mutational phenotypes; 4) demonstration of efficient interplasmidic and interchromosomal recombination occurring postirradiation; and 5) recent speculations on the mechanisms of radiation resistance and the driving forces of natural selection for DNA damage resistance in D. radiodurans. JF - Mutation research AU - Minton, K W AD - Department of Pathology, F.E. Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. minton@usuhsb.usuhs.mil Y1 - 1996/05/15/ PY - 1996 DA - 1996 May 15 SP - 1 EP - 7 VL - 363 IS - 1 SN - 0027-5107, 0027-5107 KW - Index Medicus KW - Radiation, Ionizing KW - DNA Repair KW - DNA Damage KW - Gram-Positive Cocci -- radiation effects KW - Gram-Positive Cocci -- genetics KW - Radiation Tolerance -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78040926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Repair+of+ionizing-radiation+damage+in+the+radiation+resistant+bacterium+Deinococcus+radiodurans.&rft.au=Minton%2C+K+W&rft.aulast=Minton&rft.aufirst=K&rft.date=1996-05-15&rft.volume=363&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-03 N1 - Date created - 1996-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2. AN - 78010058; 8643498 AB - Injection of mineral oils such as pristane into the peritoneal cavities of BALB/c mice results in a chronic peritonitis associated with high tissue levels of interleukin 6 (IL-6). Here we show that increased prostaglandin E2 (PGE2) synthesis causes induction of IL-6 and that expression of an inducible cyclooxygenase, Cox-2, may mediate this process. Levels of both PGE2 and IL-6 are elevated in inflammatory exudates from pristane-treated mice compared with lavage samples from untreated mice. The Cox-2 gene is induced in the peritoneal macrophage fraction isolated from the mice. A cause and effect relationship between increased macrophage PGE2 and IL-6 production is shown in vitro. When peritoneal macrophages are activated with an inflammatory stimulus (polymerized albumin), the Cox-2 gene is induced and secretion of PGE2 and IL-6 increases, with elevated PGE2 appearing before IL-6. Cotreatment with 1 microM indomethacin inhibits PGE2 production by the cells and reduces the induction of IL-6 mRNA but has no effect on Cox-2 mRNA, consistent with the fact that the drug inhibits catalytic activity of the cyclooxygenase but does not affect expression of the gene. Addition of exogenous PGE2 to macrophages induces IL-6 protein and mRNA synthesis, indicating that the eicosanoid stimulates IL-6 production at the level of gene expression. PGE2-stimulated IL-6 production is unaffected by addition of indomethacin. Taken together with the earlier finding that indomethacin diminishes the elevation of IL-6 in pristane-treated mice, the results show that PGE2 can induce IL-6 production in vivo and implicate expression of the Cox-2 gene in the regulation of this cytokine. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Hinson, R M AU - Williams, J A AU - Shacter, E AD - Departmment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 USA. Y1 - 1996/05/14/ PY - 1996 DA - 1996 May 14 SP - 4885 EP - 4890 VL - 93 IS - 10 SN - 0027-8424, 0027-8424 KW - Interleukin-6 KW - 0 KW - Isoenzymes KW - RNA, Messenger KW - Terpenes KW - pristane KW - 26HZV48DT1 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Prostaglandin-Endoperoxide Synthases KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Terpenes -- toxicity KW - Peritonitis -- immunology KW - Animals KW - Peritonitis -- etiology KW - Gene Expression KW - Disease Models, Animal KW - Macrophages, Peritoneal -- immunology KW - Mice KW - RNA, Messenger -- genetics KW - Mice, Inbred BALB C KW - Peritonitis -- enzymology KW - RNA, Messenger -- metabolism KW - Kinetics KW - In Vitro Techniques KW - Macrophages, Peritoneal -- metabolism KW - Female KW - Dinoprostone -- pharmacology KW - Dinoprostone -- biosynthesis KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Interleukin-6 -- genetics KW - Inflammation -- etiology KW - Prostaglandin-Endoperoxide Synthases -- genetics KW - Inflammation -- immunology KW - Interleukin-6 -- biosynthesis KW - Isoenzymes -- genetics KW - Inflammation -- enzymology KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78010058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Elevated+interleukin+6+is+induced+by+prostaglandin+E2+in+a+murine+model+of+inflammation%3A+possible+role+of+cyclooxygenase-2.&rft.au=Hinson%2C+R+M%3BWilliams%2C+J+A%3BShacter%2C+E&rft.aulast=Hinson&rft.aufirst=R&rft.date=1996-05-14&rft.volume=93&rft.issue=10&rft.spage=4885&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-18 N1 - Date created - 1996-07-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gut. 1991 Dec;32(12):1531-4 [1773961] Adv Prostaglandin Thromboxane Leukot Res. 1995;23:125-7 [7794421] Hematol Oncol Clin North Am. 1992 Apr;6(2):211-23 [1582969] Cancer Res. 1966 Apr;26(4):596-9 [5934894] Nature. 1975 Dec 25;258(5537):737-9 [1207758] J Exp Med. 1976 Dec 1;144(6):1554-67 [1003103] J Immunol. 1981 Oct;127(4):1591-5 [7276572] J Pharmacol Exp Ther. 1982 Feb;220(2):229-35 [6948952] Methods Enzymol. 1982;86:467-77 [6290844] Biochem Biophys Res Commun. 1983 May 16;112(3):980-5 [6847692] J Immunol Methods. 1983 Dec 16;65(1-2):55-63 [6606682] J Exp Med. 1985 May 1;161(5):996-1012 [3989472] Proc Natl Acad Sci U S A. 1985 Nov;82(21):7227-31 [2997778] Science. 1986 Aug 1;233(4763):566-9 [3726549] J Immunol Methods. 1987 May 20;99(2):259-70 [3584996] Clin Exp Immunol. 1988 Feb;71(2):320-3 [3349651] J Biol Chem. 1988 May 5;263(13):6177-82 [2452159] Arthritis Rheum. 1988 Jun;31(6):784-8 [3260102] Annu Rev Immunol. 1988;6:485-512 [3289574] Carcinogenesis. 1988 Dec;9(12):2297-304 [2847879] Eur J Immunol. 1988 Oct;18(10):1535-40 [3263920] Int J Immunopharmacol. 1991;13(8):1137-46 [1814850] Eur J Immunol. 1988 Nov;18(11):1797-801 [2462501] J Exp Med. 1989 Jan 1;169(1):333-8 [2783334] J Immunol. 1989 Apr 1;142(7):2321-4 [2784459] Biochem Biophys Res Commun. 1989 Nov 15;164(3):1358-65 [2480117] J Clin Invest. 1989 Dec;84(6):2008-11 [2592570] Biochem Biophys Res Commun. 1990 Feb 14;166(3):1163-70 [2407240] Annu Rev Immunol. 1990;8:253-78 [2188664] FASEB J. 1990 Aug;4(11):2860-7 [2199284] Agents Actions. 1990 Jun;30(3-4):403-11 [2386111] J Exp Med. 1990 Sep 1;172(3):997-1000 [2388041] Leuk Res. 1990;14(8):675-7 [2201818] J Biol Chem. 1990 Oct 5;265(28):16737-40 [2120205] Proc Soc Exp Biol Med. 1990 Nov;195(2):183-91 [2236101] Blood. 1990 Dec 15;76(12):2520-6 [2124934] Biochem Pharmacol. 1991 Mar 15-Apr 1;41(6-7):975-84 [1848981] Dig Dis Sci. 1991 May;36(5):627-33 [2022165] Eur Cytokine Netw. 1990 Oct-Nov;1(4):193-201 [2104241] Clin Immunol Immunopathol. 1992 Jan;62(1 Pt 2):S60-5 [1728989] J Clin Invest. 1992 Jan;89(1):97-108 [1729286] Blood. 1992 Jul 1;80(1):194-202 [1611085] Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7384-8 [1380156] J Biol Chem. 1992 Dec 25;267(36):25934-8 [1464605] Mol Pharmacol. 1993 Jan;43(1):64-9 [8380885] J Biol Chem. 1993 Mar 25;268(9):6610-4 [8454631] Am J Physiol. 1993 Apr;264(4 Pt 1):G601-8 [8476047] Adv Immunol. 1993;54:1-78 [8379461] Blood. 1993 Nov 1;82(9):2853-64 [8219233] J Clin Invest. 1994 Mar;93(3):1095-101 [8132748] Prostaglandins. 1994 Jan;47(1):55-9 [8140262] Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3228-32 [8159730] Inflammation. 1994 Apr;18(2):175-85 [8070901] J Exp Med. 1994 Dec 1;180(6):2365-70 [7525853] Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12013-7 [7991575] Immunol Lett. 1994 Jul;41(2-3):255-60 [8002047] J Immunol. 1995 May 1;154(9):4759-67 [7536779] Mol Cell Biol. 1992 Apr;12(4):1535-45 [1372386] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 3-Hydroxymethylcholanthrene: metabolic formation from 3-methylcholanthrene and stereoselective metabolism by rat liver microsomes. AN - 78188766; 8723742 AB - 3-Hydroxymethylcholanthrene (3-OHMC) was identified as one of the three initial hydroxylation products formed in the metabolism at the aliphatic carbons of 3-methylcholanthrene (3MC) by rat liver microsomes. The 3-OHMC formed in 3MC metabolism by liver microsomes prepared from untreated (control) rats, and rats treated with phenobarbital, 3MC, and polychlorinated biphenyls (Aroclor 1254) was determined by HPLC analysis and the effect of enzyme inducers on its formation was phenobarbital > polychlorinated biphenyls > 3MC > control. Incubation of 3-OHMC with rat liver microsomes produced the following identifiable products: 1-hydroxy-3-hydroxymethylcholanthrene (enriched in 1S-enantiomer, enantiomer excess 14-50%), 2-hydroxy-3-hydroxymethylcholanthrene (enriched in 2S-enantiomer, enantiomer excess 30-92%), 3-hydroxymethylcholanthrene-1-one, 3-hydroxymethylcholanthrene-2-one, 8-hydroxy-3-hydroxymethylcholanthrene, 3-hydroxymethylcholanthrene trans-9,10-dihydrodiol (enriched in 9R,10R-enantiomer, enantiomer excess 64-86%), 3-hydroxymethylcholanthrene trans-7,8-dihydrodiol (enriched in 7R,8R-enantiomer), and 3-hydroxymethylcholanthrene trans-11,12-dihydrodiol (enriched in 11R,12R-enantiomer). The enantiomer compositions were determined by circular dichroism spectral analysis and/or chiral stationary phase HPLC analysis. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Shou, M AU - Yang, S K AD - Department of Pharmacology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 1996/05// PY - 1996 DA - May 1996 SP - 595 EP - 601 VL - 24 IS - 5 SN - 0090-9556, 0090-9556 KW - Benz(a)Anthracenes KW - 0 KW - Carcinogens KW - 3-hydroxymethylcholanthrene KW - 3343-05-3 KW - Methylcholanthrene KW - 56-49-5 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Epoxide Hydrolases KW - EC 3.3.2.- KW - Index Medicus KW - Molecular Structure KW - Animals KW - Epoxide Hydrolases -- metabolism KW - Stereoisomerism KW - Circular Dichroism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Chromatography, High Pressure Liquid KW - Hydroxylation KW - Rats KW - Rats, Sprague-Dawley KW - Enzyme Induction KW - Spectrophotometry KW - Male KW - Methylcholanthrene -- analogs & derivatives KW - Carcinogens -- metabolism KW - Microsomes, Liver -- metabolism KW - Methylcholanthrene -- metabolism KW - Benz(a)Anthracenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78188766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=3-Hydroxymethylcholanthrene%3A+metabolic+formation+from+3-methylcholanthrene+and+stereoselective+metabolism+by+rat+liver+microsomes.&rft.au=Shou%2C+M%3BYang%2C+S+K&rft.aulast=Shou&rft.aufirst=M&rft.date=1996-05-01&rft.volume=24&rft.issue=5&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-11-05 N1 - Date created - 1996-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of Shiga-like toxins by mouse and human intestinal mucus correlates with virulence of enterohemorrhagic Escherichia coli O91:H21 isolates in orally infected, streptomycin-treated mice. AN - 78011588; 8613362 AB - The enterohemorrhagic Escherichia coli (EHEC) O91:H21 isolates B2F1 and H414-36/89 are virulent in an orally infected streptomycin-treated mouse model. Previous studies demonstrated that B2F1 and H414-36/89 grow to high levels in mucus isolated from mouse small intestine and colon and that growth in small-intestine mucus is related to virulence. We measured the levels of Shiga-like toxins (SLTs) SLT-IIvha and SLT-IIvhb produced by B2F1 after growth in Luria-Bertani (LB) broth supplemented with mouse intestinal mucus by assaying the cytotoxicity of culture supernatants on Vero cells. Culture supernatants from B2F1 grown in mouse intestinal mucus, but not EHEC strains that produce SLT-II or SLT-IIc, were approximately 35- to 350-fold more toxic for Vero cells than supernatants from B2F1 grown in LB broth. This increased toxicity was not reflected by a concomitant increase in SLT antigen content. Furthermore, when culture supernatants from B2F1 or K-12 strains carrying plasmids encoding SLTs cloned from H414-36/89 or purified SLT-IIvhb from B2F1 were incubated with mouse intestinal mucus, the samples exhibited greater cytotoxicity than when they were incubated with N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES) buffer alone. These toxin preparations also showed increased cytotoxicity after incubation with human colonic mucus. In contrast, culture supernatants from LB-grown EHEC isolates that produced SLT-I, SLT-II, SLT-IIc or SLT-IIe did not show increased cytotoxicity after incubation with mouse or human intestinal mucus. The A subunits of purified SLT-II and SLT-IIvhb that had been treated with mouse intestinal mucus or trypsin were cleaved to A1 fragments by the mucus, but trypsin-mediated cleavage, unlike treatment with mouse intestinal mucus, did not result in increased Vero cell cytotoxicity activity. This finding implies that the increased cytotoxicity of SLT-IIvhb detected after incubation with mucus is probably not due to cleavage of the A subunit into the A1 and A2 fragments. Taken together, these results indicate that mouse or human intestinal mucus directly activates SLT-II-related toxins from B2F1 and H414-36/89 and suggest that toxin activation may explain the low 50% lethal doses of B2F1 and H414-36/89 in streptomycin-treated mice. JF - Infection and immunity AU - Melton-Celsa, A R AU - Darnell, S C AU - O'Brien, A D AD - Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services, University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1996/05// PY - 1996 DA - May 1996 SP - 1569 EP - 1576 VL - 64 IS - 5 SN - 0019-9567, 0019-9567 KW - Bacterial Toxins KW - 0 KW - Enterotoxins KW - Shiga Toxin 1 KW - Shiga Toxin 2 KW - Streptomycin KW - Y45QSO73OB KW - Index Medicus KW - Mucus -- metabolism KW - Animals KW - Humans KW - Mice KW - Intestines -- metabolism KW - Models, Biological KW - Virulence KW - Streptomycin -- therapeutic use KW - Cercopithecus aethiops KW - In Vitro Techniques KW - Vero Cells KW - Species Specificity KW - Male KW - Bacterial Toxins -- genetics KW - Escherichia coli -- metabolism KW - Enterotoxins -- chemistry KW - Bacterial Toxins -- metabolism KW - Enterotoxins -- metabolism KW - Escherichia coli Infections -- drug therapy KW - Escherichia coli -- pathogenicity KW - Escherichia coli Infections -- metabolism KW - Escherichia coli -- genetics KW - Enterotoxins -- genetics KW - Bacterial Toxins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78011588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Activation+of+Shiga-like+toxins+by+mouse+and+human+intestinal+mucus+correlates+with+virulence+of+enterohemorrhagic+Escherichia+coli+O91%3AH21+isolates+in+orally+infected%2C+streptomycin-treated+mice.&rft.au=Melton-Celsa%2C+A+R%3BDarnell%2C+S+C%3BO%27Brien%2C+A+D&rft.aulast=Melton-Celsa&rft.aufirst=A&rft.date=1996-05-01&rft.volume=64&rft.issue=5&rft.spage=1569&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-06-06 N1 - Date created - 1996-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] Microbiol Immunol. 1993;37(8):591-9 [8246822] J Exp Med. 1986 Jun 1;163(6):1391-404 [3519828] J Biol Chem. 1987 Feb 5;262(4):1779-85 [3543013] J Biol Chem. 1987 Apr 25;262(12):5908-12 [3571242] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] Infect Immun. 1988 Dec;56(12):3099-109 [3053452] Ann Intern Med. 1988 Nov 1;109(9):705-12 [3056169] J Biol Chem. 1989 Jan 5;264(1):596-601 [2642481] Infect Immun. 1990 Mar;58(3):611-8 [2155181] Microb Pathog. 1990 Jan;8(1):47-60 [2185397] Infect Immun. 1990 Aug;58(8):2438-45 [2196227] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] Infect Immun. 1990 Dec;58(12):3959-65 [2254023] Infect Immun. 1991 Mar;59(3):1065-73 [1997410] J Clin Microbiol. 1991 Dec;29(12):2704-9 [1757536] Mol Microbiol. 1991 Aug;5(8):1817-22 [1766367] Infect Immun. 1994 Feb;62(2):623-31 [8300218] Infect Immun. 1994 Nov;62(11):5085-94 [7927791] Mol Microbiol. 1993 Oct;10(1):171-9 [7968513] J Bacteriol. 1995 Jun;177(11):3128-32 [7768810] Infect Immun. 1995 Jul;63(7):2450-8 [7790056] Nat Struct Biol. 1994 Jan;1(1):59-64 [7656009] Zentralbl Bakteriol. 1992 Jan;276(2):189-95 [1559007] Infect Immun. 1993 Feb;61(2):534-43 [8423084] Microb Pathog. 1992 Sep;13(3):225-36 [1291844] J Mol Biol. 1993 Apr 5;230(3):890-918 [8478941] Infect Immun. 1993 Aug;61(8):3392-402 [8335369] Infect Immun. 1993 Sep;61(9):3832-42 [8359904] Microb Pathog. 1993 Jul;15(1):77-82 [8412629] Infect Immun. 1985 Dec;50(3):695-700 [3905611] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Heat shock mimics glucocorticoid effects on IFN-gamma-induced Fc gamma RI and Ia messenger RNA expression in mouse peritoneal macrophages. AN - 77995579; 8617972 AB - Glucocorticoids activate or repress the expression of different genes. In murine macrophages, glucocorticoids exert opposing effects on the IFN-gamma-induced expression of Fc gamma RI and Ia mRNA and cell surface expression; they enhance IFN-gamma-induced Fc gamma RI mRNA and protein expression, yet inhibit IFN-gamma-induced Ia mRNA and protein expression. Recently, in transfected cell lines, heat shock (HS) has been shown to promote nuclear accumulation of the glucocorticoid receptor (GR), resulting in potentiation of certain GR-mediated responses. In this study, we compared the effects of HS and dexamethasone (DEX) treatment on the IFN-gamma induction of Fc gamma RI and Ia mRNA in murine primary peritoneal macrophages. Our results show that HS exerted the same opposing effects on these IFN-gamma-responsive genes as DEX at 37 degrees C. The glucocorticoid antagonist RU 486 blocked both DEX and HS-induced enhancement of IFN-gamma induction of Fc gamma RI, suggesting a common GR-mediated mechanism. While RU 486 also reversed DEX-induced repression of Ia mRNA expression, supporting a GR-mediated action, it did not affect HS-mediated repression, raising the possibility of a ligand-independent HS response pathway. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Sivo, J AU - Harmon, J M AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 1996/05/01/ PY - 1996 DA - 1996 May 01 SP - 3450 EP - 3454 VL - 156 IS - 9 SN - 0022-1767, 0022-1767 KW - Culture Media, Serum-Free KW - 0 KW - Histocompatibility Antigens Class II KW - RNA, Messenger KW - Receptors, Glucocorticoid KW - Receptors, IgG KW - Mifepristone KW - 320T6RNW1F KW - Dexamethasone KW - 7S5I7G3JQL KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Receptors, Glucocorticoid -- drug effects KW - Cells, Cultured KW - Mice, Inbred C3H KW - Mice KW - Gene Expression Regulation -- drug effects KW - Culture Media, Serum-Free -- pharmacology KW - Mifepristone -- pharmacology KW - Female KW - Histocompatibility Antigens Class II -- genetics KW - RNA, Messenger -- drug effects KW - Interferon-gamma -- pharmacology KW - Macrophages, Peritoneal -- drug effects KW - RNA, Messenger -- biosynthesis KW - Receptors, IgG -- biosynthesis KW - Dexamethasone -- toxicity KW - Interferon-gamma -- drug effects KW - Receptors, IgG -- drug effects KW - Dexamethasone -- antagonists & inhibitors KW - Macrophages, Peritoneal -- metabolism KW - Hot Temperature -- adverse effects KW - Receptors, IgG -- genetics KW - Histocompatibility Antigens Class II -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77995579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Heat+shock+mimics+glucocorticoid+effects+on+IFN-gamma-induced+Fc+gamma+RI+and+Ia+messenger+RNA+expression+in+mouse+peritoneal+macrophages.&rft.au=Sivo%2C+J%3BHarmon%2C+J+M%3BVogel%2C+S+N&rft.aulast=Sivo&rft.aufirst=J&rft.date=1996-05-01&rft.volume=156&rft.issue=9&rft.spage=3450&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-06-13 N1 - Date created - 1996-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Holocene aggradation and paleoagriculture in the Southwest Colorado Plateau AN - 52794138; 1996-081491 JF - Program and Abstracts - American Quaternary Association. Conference AU - Lucchitta, Ivo AU - Coder, C M AU - Hasbargen, J AU - Davis, S W AU - Davis, M E AU - Finkel, R C AU - Anonymous Y1 - 1996/05// PY - 1996 DA - May 1996 SP - 101 PB - American Quaternary Association, Seattle, WA VL - 14 SN - 0741-059X, 0741-059X KW - United States KW - terrestrial environment KW - stream transport KW - Quaternary KW - Colorado Plateau KW - isotopes KW - arid environment KW - agriculture KW - aggradation KW - Holocene KW - Cenozoic KW - southwestern Colorado Plateau KW - radioactive isotopes KW - dates KW - carbon KW - absolute age KW - C-14 KW - pH KW - climate KW - changes KW - 24:Quaternary geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52794138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Program+and+Abstracts+-+American+Quaternary+Association.+Conference&rft.atitle=Holocene+aggradation+and+paleoagriculture+in+the+Southwest+Colorado+Plateau&rft.au=Lucchitta%2C+Ivo%3BCoder%2C+C+M%3BHasbargen%2C+J%3BDavis%2C+S+W%3BDavis%2C+M+E%3BFinkel%2C+R+C%3BAnonymous&rft.aulast=Lucchitta&rft.aufirst=Ivo&rft.date=1996-05-01&rft.volume=14&rft.issue=&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Program+and+Abstracts+-+American+Quaternary+Association.+Conference&rft.issn=0741059X&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - AMQUA 1996; 14th biennial meeting of the American Quaternary Association N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - WA N1 - Last updated - 2012-06-07 N1 - CODEN - AMQUAM N1 - SubjectsTermNotLitGenreText - absolute age; aggradation; agriculture; arid environment; C-14; carbon; Cenozoic; changes; climate; Colorado Plateau; dates; Holocene; isotopes; pH; Quaternary; radioactive isotopes; southwestern Colorado Plateau; stream transport; terrestrial environment; United States ER - TY - JOUR T1 - Grapefruit juice alters the systemic bioavailability and cardiac repolarization of terfenadine in poor metabolizers of terfenadine. AN - 78166884; 8728348 AB - A prospective cohort study was conducted to examine the effects of double-strength grapefruit juice on the pharmacokinetics and electrocardiographic repolarization pharmacodynamics of terfenadine in poor metabolizers of terfenadine. Six healthy volunteers who were previously found to be poor metabolizers of terfenadine were studied, with each participant serving as his or her own control. In phase I of the study, terfenadine was given to participants at recommended dosages until steady state was achieved (60 mg twice daily for 7 days). In phase II, participants began receiving concomitant twice-daily, double-strength servings of grapefruit juice for 7 days. Serial pharmacokinetic and pharmacodynamic determinations were made after each phase of the study. The main outcome measures were serum concentrations of terfenadine and terfenadine acid metabolite, and corrected QT intervals as determined by 12-lead electrocardiogram. Significant changes occurred in time to maximum concentration (t(max)) and area under the concentration-time curve (AUC) of terfenadine and terfenadine acid metabolite after addition of grapefruit juice. All participants had detectable concentrations of unmetabolized terfenadine at the end of Phase I, which were quantified in three of the six participants. Further, all participants had increased and quantifiable levels of unmetabolized terfenadine after addition of grapefruit juice that were associated with prolongation of the QT interval relative to the baseline control period without terfenadine. Grapefruit juice did not alter the elimination half-life (t1/2) of terfenadine acid metabolite. Because of the intraindividual variability in the pharmacokinetics of terfenadine, further study is needed to confirm these results. JF - Journal of clinical pharmacology AU - Honig, P K AU - Wortham, D C AU - Lazarev, A AU - Cantilena, L R AD - Division of Clinical Pharmacology of the Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1996/04// PY - 1996 DA - April 1996 SP - 345 EP - 351 VL - 36 IS - 4 SN - 0091-2700, 0091-2700 KW - Histamine H1 Antagonists KW - 0 KW - Terfenadine KW - 7BA5G9Y06Q KW - Index Medicus KW - Phenotype KW - Prospective Studies KW - Humans KW - Cohort Studies KW - Adult KW - Electroencephalography -- drug effects KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Biological Availability KW - Citrus KW - Histamine H1 Antagonists -- pharmacokinetics KW - Beverages KW - Terfenadine -- pharmacokinetics KW - Food-Drug Interactions KW - Terfenadine -- blood KW - Histamine H1 Antagonists -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78166884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Grapefruit+juice+alters+the+systemic+bioavailability+and+cardiac+repolarization+of+terfenadine+in+poor+metabolizers+of+terfenadine.&rft.au=Honig%2C+P+K%3BWortham%2C+D+C%3BLazarev%2C+A%3BCantilena%2C+L+R&rft.aulast=Honig&rft.aufirst=P&rft.date=1996-04-01&rft.volume=36&rft.issue=4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-09-30 N1 - Date created - 1996-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Postmilitary Earnings of Female Veterans AN - 61533433; 9700727 AB - Analysis of standard datasets & responses to a special survey of 60,120 US military reservists reveals that female (F) veterans have better earnings endowments than nonveterans. Although F veterans have higher unadjusted earnings than nonveterans, a wage disadvantage is found for white, but not nonwhite, veterans following control for measured & unmeasured skills. Low returns to military service may result from historically limited military opportunities for women & difficulty in transferring skills to civilian jobs. 4 Tables, 1 Appendix, 31 References. Adapted from the source document. JF - Industrial Relations AU - Mehay, Stephen L AU - Hirsch, Barry T AD - Dept Systems Management US Naval Postgraduate School, Monterey CA 93943 Y1 - 1996/04// PY - 1996 DA - April 1996 SP - 197 EP - 217 VL - 35 IS - 2 SN - 0019-8676, 0019-8676 KW - postservice earnings, female military veterans, racial differences KW - Veterans KW - Military Personnel KW - Income Inequality KW - Racial Differences KW - Females KW - Income KW - article KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61533433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Relations&rft.atitle=The+Postmilitary+Earnings+of+Female+Veterans&rft.au=Mehay%2C+Stephen+L%3BHirsch%2C+Barry+T&rft.aulast=Mehay&rft.aufirst=Stephen&rft.date=1996-04-01&rft.volume=35&rft.issue=2&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Industrial+Relations&rft.issn=00198676&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IDRLAP N1 - SubjectsTermNotLitGenreText - Veterans; Income Inequality; Females; Income; Racial Differences; Military Personnel ER - TY - JOUR T1 - Inhalation of nitrous oxide expands epidural air bubbles. AN - 78088432; 8829407 AB - Epidural air bubbles are known to persist for more than 24 hours after injection. Nitrous oxide may cause expansion of these bubbles. Nine dogs were anesthetized. Ten mL air and 9 mL of iophendylate were injected into the lumbar epidural space. Control animals (n = 3) breathed halothane in 100% oxygen. Experimental animals (n = 6) breathed halothane in 70/30 nitrous oxide/oxygen. Lateral radiographs were taken before and just after injection, and again 3 hours after breathing either 70% nitrous oxide or 100% oxygen. Epidural space pressure was monitored and recorded during these 3 hours. In all experimental animals, an increase in bubble size was observed. In the control animals, bubble size either remained the same or decreased. Epidural space pressure did not change in any animal. Inhalation of nitrous oxide results in expansion of epidural air bubbles. This may cause displacement of epidural local anesthetics it large volumes of air are present in the epidural space. JF - Regional anesthesia AU - Petty, R AU - Stevens, R AU - Erickson, S AU - Lucio, J AU - Kao, T C AD - Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. PY - 1996 SP - 144 EP - 148 VL - 21 IS - 2 SN - 0146-521X, 0146-521X KW - Anesthetics, Inhalation KW - 0 KW - Nitrous Oxide KW - K50XQU1029 KW - Index Medicus KW - Animals KW - Dogs KW - Radiography KW - Male KW - Female KW - Anesthetics, Inhalation -- adverse effects KW - Nitrous Oxide -- adverse effects KW - Epidural Space -- pathology KW - Epidural Space -- diagnostic imaging KW - Anesthesia, Epidural KW - Nitrous Oxide -- administration & dosage KW - Anesthetics, Inhalation -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78088432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regional+anesthesia&rft.atitle=Inhalation+of+nitrous+oxide+expands+epidural+air+bubbles.&rft.au=Petty%2C+R%3BStevens%2C+R%3BErickson%2C+S%3BLucio%2C+J%3BKao%2C+T+C&rft.aulast=Petty&rft.aufirst=R&rft.date=1996-03-01&rft.volume=21&rft.issue=2&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Regional+anesthesia&rft.issn=0146521X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-10-16 N1 - Date created - 1996-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patients with limited-stage small-cell lung cancer treated with concurrent twice-daily chest radiotherapy and etoposide/cisplatin followed by cyclophosphamide, doxorubicin, and vincristine. AN - 77981020; 8622028 AB - A phase II trial in patients with limited-stage small-cell lung cancer treated with induction etoposide/cisplatin plus twice-daily chest radiotherapy was conducted in an attempt to increase response rates and prolong survival. Fifty-four previously untreated patients with limited-stage small-cell cancer were treated with etoposide/cisplatin and concurrent radiotherapy at 1.5 Gy twice daily for 3 weeks to a total dose of 45 Gy. Patients then received three more cycles of etoposide/cisplatin followed by four cycles of vincristine, doxorubicin, and cyclophosphamide or an individualized chemotherapy regimen. Nine patients are alive and free of cancer a median of 4 years (range, 2 to 7) from the start of treatment. Thirty-eight have had progression of their cancer at a median of 1.2 years (range, 0.5 to 5.4) and all have died of small-cell cancer. Thirteen of these 38 patients' (34%) only site of initial relapse was in the CNS and all died of CNS metastases. Five patients died during therapy or from its complications and two patients died of causes other than relapsed small-cell lung cancer and toxicity. The median survival time is 21.3 months, with an actual survival rate of 83% at 1 year, and actuarial survival rates of 43% at 2 years and 19% at 5 years. This combined modality regimen for patients with limited-stage small-cell lung cancer results in a 2-year survival rate of 43%, but the principal cause of death in these patients is still relapse of the original cancer. Isolated CNS metastases caused more than 30% of the cancer deaths. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Johnson, B E AU - Bridges, J D AU - Sobczeck, M AU - Gray, J AU - Linnoila, R I AU - Gazdar, A F AU - Hankins, L AU - Steinberg, S M AU - Edison, M AU - Frame, J N AU - Pass, H AU - Nesbitt, J AU - Holden, D AU - Mulshine, J L AU - Glatstein, E AU - Ihde, D C AD - National Cancer Institute-Navy Medical Oncology, National Naval Medical Center Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Y1 - 1996/03// PY - 1996 DA - March 1996 SP - 806 EP - 813 VL - 14 IS - 3 SN - 0732-183X, 0732-183X KW - Vincristine KW - 5J49Q6B70F KW - Etoposide KW - 6PLQ3CP4P3 KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Doxorubicin -- adverse effects KW - Vincristine -- adverse effects KW - Combined Modality Therapy KW - Humans KW - Vincristine -- administration & dosage KW - Aged KW - Doxorubicin -- administration & dosage KW - Cranial Irradiation KW - Brain Neoplasms -- secondary KW - Cause of Death KW - Cisplatin -- administration & dosage KW - Cyclophosphamide -- adverse effects KW - Etoposide -- administration & dosage KW - Radiotherapy Dosage KW - Adult KW - Brain Neoplasms -- prevention & control KW - Etoposide -- adverse effects KW - Middle Aged KW - Cisplatin -- adverse effects KW - Male KW - Female KW - Remission Induction KW - Carcinoma, Small Cell -- pathology KW - Lung Neoplasms -- radiotherapy KW - Carcinoma, Small Cell -- mortality KW - Lung Neoplasms -- drug therapy KW - Carcinoma, Small Cell -- secondary KW - Carcinoma, Small Cell -- radiotherapy KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Small Cell -- drug therapy KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77981020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Patients+with+limited-stage+small-cell+lung+cancer+treated+with+concurrent+twice-daily+chest+radiotherapy+and+etoposide%2Fcisplatin+followed+by+cyclophosphamide%2C+doxorubicin%2C+and+vincristine.&rft.au=Johnson%2C+B+E%3BBridges%2C+J+D%3BSobczeck%2C+M%3BGray%2C+J%3BLinnoila%2C+R+I%3BGazdar%2C+A+F%3BHankins%2C+L%3BSteinberg%2C+S+M%3BEdison%2C+M%3BFrame%2C+J+N%3BPass%2C+H%3BNesbitt%2C+J%3BHolden%2C+D%3BMulshine%2C+J+L%3BGlatstein%2C+E%3BIhde%2C+D+C&rft.aulast=Johnson&rft.aufirst=B&rft.date=1996-03-01&rft.volume=14&rft.issue=3&rft.spage=806&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-06-20 N1 - Date created - 1996-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multilayered dermal subcompartments for modeling chemical absorption. AN - 78731843; 9114511 AB - Dermal penetration of chemicals and drugs is of concern to both toxicologists and pharmacologists. Environmental professionals try to limit exposure to chemicals using protective clothing and gloves or barrier creams to trap chemicals. Drug developers try to enhance penetration of chemicals through the skin for medical purposes. Both can use predictive biologically-based mathematical models to assist in understanding the processes involved. These models are especially useful when they are based on physiological and biochemical parameters which can be measured in the laboratory. Appropriately validated models based on conservation of mass, diffusion and chemical transport by flow can be predictive of human exposures. In this paper we develop two new physiologically-based pharmacokinetic (PBPK) skin models to predict blood concentrations of dibromomethane in rats after skin-only vapor exposures. These new models improve the predictions of the blood concentrations especially at the beginning of the exposures. Sensitivity analysis shows that the permeability constants followed by partition coefficients have the most impact on blood concentration predictions. With proper validation the new models could be used to improve species, dose, and duration extrapolations of chemical or drug penetration. They could also be used to investigate and predict concentrations of drugs or chemicals in the skin. JF - SAR and QSAR in environmental research AU - Bookout, R L AU - McDaniel, C R AU - Quinn, D W AU - McDougal, J N AD - Air Force Institute of Technology, Wright-Patterson AFB, OH 45433, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 133 EP - 150 VL - 5 IS - 3 SN - 1062-936X, 1062-936X KW - Hydrocarbons, Brominated KW - 0 KW - Mutagens KW - methylene bromide KW - V69B659W01 KW - Index Medicus KW - Rats KW - Permeability KW - Animals KW - Hypersensitivity, Delayed KW - Humans KW - Volatilization KW - Predictive Value of Tests KW - Diffusion KW - Structure-Activity Relationship KW - Hydrocarbons, Brominated -- pharmacokinetics KW - Hydrocarbons, Brominated -- metabolism KW - Skin Absorption -- drug effects KW - Skin -- anatomy & histology KW - Skin -- metabolism KW - Mutagens -- metabolism KW - Mutagens -- pharmacokinetics KW - Models, Biological KW - Skin Absorption -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78731843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SAR+and+QSAR+in+environmental+research&rft.atitle=Multilayered+dermal+subcompartments+for+modeling+chemical+absorption.&rft.au=Bookout%2C+R+L%3BMcDaniel%2C+C+R%3BQuinn%2C+D+W%3BMcDougal%2C+J+N&rft.aulast=Bookout&rft.aufirst=R&rft.date=1996-01-01&rft.volume=5&rft.issue=3&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=SAR+and+QSAR+in+environmental+research&rft.issn=1062936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-13 N1 - Date created - 1997-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deadly sins, continued: treating patients with addictions. AN - 78646006; 8981190 JF - The Journal of clinical ethics AU - Howe, E G AD - Uniformed Services University of the Health Sciences in Bethesda, MD, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 195 EP - 204 VL - 7 IS - 3 SN - 1046-7890, 1046-7890 KW - Bioethics KW - Index Medicus KW - Analytical Approach KW - Professional Patient Relationship KW - Prejudice KW - Emotions KW - Compulsive Behavior KW - Ethicists KW - Morals KW - Attitude of Health Personnel KW - Humans KW - Substance-Related Disorders -- therapy KW - Internal-External Control KW - Ethics, Medical KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78646006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+ethics&rft.atitle=Deadly+sins%2C+continued%3A+treating+patients+with+addictions.&rft.au=Howe%2C+E+G&rft.aulast=Howe&rft.aufirst=E&rft.date=1996-01-01&rft.volume=7&rft.issue=3&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+ethics&rft.issn=10467890&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-18 N1 - Date created - 1997-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of soman (pinacolyl methylphosphonofluoridate) on coronary blood flow and cardiac function in swine. AN - 78386759; 8838649 AB - The effects of soman (pinacolyl methylphosphonofluoridate) on coronary blood flow, the electrocardiogram, and cardiac function were measured in alpha-chloralose-anesthetized swine. Coronary blood flow (CBF), mean arterial blood pressure (MAP), peak systolic left ventricular pressure (IVP), maximum rate of left ventricular pressure development (dP/dtmax), cardiac output, and the ECG were monitored continuously. A dose of 2X LD50 of soman (1 LD50 = 4.6 micrograms/kg) was given at 1 LD50/min in the femoral vein, which produced an increase in coronary sinus plasma acetylcholine (ACh) from a control of 0.7 +/- 0.01 nmol/ml to a maximum 314% of control at 15 min and a decrease in CBF from a control of 99 +/- 13 ml/min/100 g to a minimum 55% of control at 15 min. The increase in ACh in the coronary sinus was significantly correlated with a decrease in CBF (r = -0.87, p < 0.001). The fall in CBF was accompanied by concomitant decreases in IVP, MAP, and dP/dtmax, with S-T segment elevation and ventricular fibrillation. The increase in coronary sinus acetylcholine concentration was significantly correlated with a 10-fold fall in coronary sinus acetylcholinesterase levels from a control of 2.47 +/- 0.97 mol acetylcholine hydrolyzed/ml blood/min and was consistent with the time course for the reduced hemodynamic measurements. These studies support the hypothesis that acetylcholine increases following soman toxicity may decrease coronary blood flow, thereby initiating ischemic electrocardiographic changes and reducing cardiac function. JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - McKenzie, J E AU - Scandling, D M AU - Ahle, N W AU - Bryant, H J AU - Kyle, R R AU - Abbrecht, P H AD - Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1996/01// PY - 1996 DA - January 1996 SP - 140 EP - 146 VL - 29 IS - 1 SN - 0272-0590, 0272-0590 KW - Cholinesterase Inhibitors KW - 0 KW - Soman KW - 96-64-0 KW - Index Medicus KW - Swine KW - Hemodynamics -- drug effects KW - Animals KW - Electrocardiography KW - Neurochemistry KW - Cardiac Output -- drug effects KW - Metabolism KW - Male KW - Heart Function Tests KW - Cholinesterase Inhibitors -- toxicity KW - Soman -- toxicity KW - Heart -- drug effects KW - Coronary Circulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78386759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Effects+of+soman+%28pinacolyl+methylphosphonofluoridate%29+on+coronary+blood+flow+and+cardiac+function+in+swine.&rft.au=McKenzie%2C+J+E%3BScandling%2C+D+M%3BAhle%2C+N+W%3BBryant%2C+H+J%3BKyle%2C+R+R%3BAbbrecht%2C+P+H&rft.aulast=McKenzie&rft.aufirst=J&rft.date=1996-01-01&rft.volume=29&rft.issue=1&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-11 N1 - Date created - 1996-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment. AN - 78365268; 8825358 AB - 1. Morphine produces a plethora of pharmacological effects and its chronic administration induces several side-effects. The cellular mechanisms by which opiates induce these side-effects are not fully understood. Several studies suggest that regulation of adenylyl cyclase activity by opioids and other transmitters plays an important role in the control of neural function. 2. The aim of this study was to evaluate desensitization of mu- and delta- opioid receptors, defined as a reduced ability of opioid agonists to inhibit adenylyl cyclase activity, in four different brain structures known to be involved in opiate drug actions: caudate putamen, nucleus accumbens, thalamus and periaqueductal gray (PAG). Opiate regulation of adenylyl cyclase in these regions has been studied in control and morphine-dependent rats. 3. The chronic morphine treatment used in the present study (subcutaneous administration of 15.4 mg morphine/rat/day for 6 days via osmotic pump) induced significant physical dependence as indicated by naloxone-precipitated withdrawal symptoms. 4. Basal adenylyl cyclase in the four brain regions was not modified by this chronic morphine treatment. In the PAG and the thalamus, a desensitization of mu- and delta-opioid receptors was observed, characterized by a reduced ability of Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol (DAMGO; mu), Tyr-D-Pen-Gly-Phe-D-Pen (DPDPE; delta) and [D-Ala2]-deltorphin-II (DT-II; delta) to inhibit adenylyl cyclase, activity following chronic morphine treatment. 5. The opioid receptor desensitization in PAG and thalamus appeared to be heterologous since the metabotropic glutamate receptor agonists, L-AP4 and glutamate, and the 5-hydroxytryptamine (5-HT)1A receptor agonist, R(+)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT), also showed reduced inhibition of adenylyl cyclase activity following chronic morphine treatment. 6. In the nucleus accumbens and the caudate putamen, desensitization of delta-opioid receptor-mediated inhibition without modification of mu-opioid receptor-mediated inhibition was observed. An indirect mechanism probably involving dopaminergic systems is proposed to explain the desensitization of delta-mediated responses and the lack of mu-opioid receptor desensitization after chronic morphine treatment in caudate putamen and nucleus accumbens. 7. These results suggest that adaptive responses occurring during chronic morphine administration are not identical in all opiate-sensitive neural populations. JF - British journal of pharmacology AU - Noble, F AU - Cox, B M AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 1996/01// PY - 1996 DA - January 1996 SP - 161 EP - 169 VL - 117 IS - 1 SN - 0007-1188, 0007-1188 KW - Aminobutyrates KW - 0 KW - Analgesics KW - Enkephalins KW - Narcotic Antagonists KW - Oligopeptides KW - Receptors, Opioid, delta KW - Receptors, Opioid, mu KW - Serotonin Receptor Agonists KW - Enkephalin, Ala(2)-MePhe(4)-Gly(5)- KW - 100929-53-1 KW - deltorphin II, Ala(2)- KW - 122752-16-3 KW - Naloxone KW - 36B82AMQ7N KW - Glutamic Acid KW - 3KX376GY7L KW - 2-amino-4-phosphonobutyric acid KW - 6323-99-5 KW - Morphine KW - 76I7G6D29C KW - 8-Hydroxy-2-(di-n-propylamino)tetralin KW - 78950-78-4 KW - Enkephalin, D-Penicillamine (2,5)- KW - 88373-73-3 KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - Serotonin Receptor Agonists -- pharmacology KW - Animals KW - Substance Withdrawal Syndrome KW - Periaqueductal Gray -- physiopathology KW - Nucleus Accumbens -- drug effects KW - Analgesics -- pharmacology KW - Caudate Nucleus -- physiopathology KW - Caudate Nucleus -- drug effects KW - Thalamus -- drug effects KW - Periaqueductal Gray -- drug effects KW - Nucleus Accumbens -- physiopathology KW - Glutamic Acid -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Enkephalins -- pharmacology KW - Aminobutyrates -- pharmacology KW - 8-Hydroxy-2-(di-n-propylamino)tetralin -- pharmacology KW - Thalamus -- physiopathology KW - Oligopeptides -- pharmacology KW - Male KW - Brain -- physiopathology KW - Morphine Dependence -- physiopathology KW - Brain -- drug effects KW - Adenylyl Cyclases -- metabolism KW - Receptors, Opioid, mu -- drug effects KW - Receptors, Opioid, delta -- drug effects KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78365268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+pharmacology&rft.atitle=Differential+desensitization+of+mu-+and+delta-+opioid+receptors+in+selected+neural+pathways+following+chronic+morphine+treatment.&rft.au=Noble%2C+F%3BCox%2C+B+M&rft.aulast=Noble&rft.aufirst=F&rft.date=1996-01-01&rft.volume=117&rft.issue=1&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=British+journal+of+pharmacology&rft.issn=00071188&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-11-22 N1 - Date created - 1996-11-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Pharmacol. 1994 Jul 15;268(2):215-21 [7957643] J Pharmacol Exp Ther. 1992 May;261(2):669-77 [1578378] Neuropharmacology. 1994 Mar-Apr;33(3-4):261-73 [7984266] Neurosci Biobehav Rev. 1994 Fall;18(3):373-83 [7984355] Trends Neurosci. 1994 Sep;17(9):379-89 [7817403] Neuroscience. 1994 Aug;61(4):727-32 [7838371] J Neurochem. 1995 Jul;65(1):125-33 [7790855] Neuropharmacology. 1994 Mar-Apr;33(3-4):275-317 [7984267] Behav Brain Res. 1986 Nov;22(2):107-16 [2878670] Pharmacol Biochem Behav. 1986 Dec;25(6):1263-9 [3809229] Life Sci. 1987 Jul 20;41(3):377-83 [3600184] Mol Pharmacol. 1988 Feb;33(2):127-32 [3340078] Mol Pharmacol. 1988 May;33(5):520-7 [2835651] J Pharmacol Exp Ther. 1988 Sep;246(3):1033-9 [2843624] J Neurochem. 1989 Feb;52(2):360-9 [2536070] Brain Res. 1989 Jan 9;476(2):230-9 [2495149] Biochem J. 1971 Feb;121(3):561-2 [4330379] Behav Biol. 1974 Jul;11(3):303-13 [4411999] Proc Natl Acad Sci U S A. 1975 Aug;72(8):3092-6 [1059094] Brain Res. 1976 Feb 27;103(3):501-13 [1252940] Psychopharmacologia. 1976 Mar 16;46(2):141-7 [986052] Anal Biochem. 1977 Dec;83(2):346-56 [603028] Nature. 1978 Nov 9;276(5684):186-8 [216919] Eur J Pharmacol. 1981 Apr 9;70(4):531-40 [6263640] Behav Brain Res. 1982 Jun;5(2):225-9 [7104089] Life Sci. 1982 Jul 19;31(3):241-7 [7121205] Proc Natl Acad Sci U S A. 1983 Oct;80(19):5871-4 [6310598] Annu Rev Neurosci. 1984;7:309-38 [6143527] Peptides. 1984 Nov-Dec;5(6):1159-65 [6397732] J Neurosci. 1992 Jun;12(6):2165-76 [1376774] J Pharmacol Exp Ther. 1992 Jul;262(1):1-9 [1625189] J Neurosci. 1993 Apr;13(4):1372-8 [8463825] Life Sci. 1993;52(21):1685-93 [8388977] Neuron. 1993 Dec;11(6):995-1006 [8274284] J Biol Chem. 1994 Jan 14;269(2):1231-6 [8288585] Synapse. 1993 Sep;15(1):33-8 [8310423] Eur J Pharmacol. 1994 Jan 15;266(2):187-92 [8157072] Brain Res Mol Brain Res. 1994 Mar;22(1-4):236-44 [8015383] Pain. 1994 Jun;57(3):341-9 [7936712] Brain Res. 1994 Jul 25;652(1):9-16 [7953726] Proc Natl Acad Sci U S A. 1989 Jul;86(13):5188-92 [2544892] Psychopharmacology (Berl). 1989;98(4):530-4 [2505294] Eur J Pharmacol. 1989 Oct 4;169(1):153-7 [2599009] Life Sci. 1989;45(20):1937-42 [2557508] Psychopharmacology (Berl). 1990;100(4):451-8 [2320705] J Neurosci. 1990 Jul;10(7):2308-17 [2115910] Neuroscience. 1990;37(3):767-73 [2247222] J Neurochem. 1991 Jul;57(1):344-7 [1675665] Pharmacol Biochem Behav. 1991 Mar;38(3):555-9 [1648748] Brain Res. 1991 May 10;548(1-2):100-10 [1651140] Psychopharmacology (Berl). 1991;104(3):377-85 [1924645] J Neurochem. 1992 May;58(5):1620-5 [1313849] Brain Res. 1994 Aug 8;653(1-2):16-22 [7982048] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression of recA in Deinococcus radiodurans. AN - 77928777; 8550406 AB - Deinococcus (formerly Micrococcus) radiodurans is remarkable for its extraordinary resistance to ionizing and UV irradiation and many other agents that damage DNA. This organism can repair > 100 double-strand breaks per chromosome induced by ionizing radiation without lethality or mutagenesis. We have previously observed that expression of D. radiodurans recA in Escherichia coli appears lethal. We now find that the RecA protein of D. radiodurans is ot detectable in D. radiodurans except in the setting of DNA damage and that termination of its synthesis is associated with the onset of deinococcal growth. The synthesis of Shigella flexneri RecA (protein sequence identical to that of E. coli RecA) in recA-defective D. radiodurans is described. Despite a large accumulation of the S. flexneri RecA in D. radiodurans, there is no complementation of any D. radiodurans recA phenotype, including DNA damage sensitivity, inhibition of natural transformation, or inability to support a plasmid that requires RecA for replication. To ensure that the cloned S. flexneri recA gene was not inactivated, it was rescued from D. radiodurans and was shown to function normally in E. coli. We conclude that neither D. radiodurans nor S. flexneri RecA is functional in the other species, nor are the kinetics of induction and suppression similar to each other, indicating a difference between these two proteins in their modes of action. JF - Journal of bacteriology AU - Carroll, J D AU - Daly, M J AU - Minton, K W AD - Department of Pathology, F. E. Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1996/01// PY - 1996 DA - January 1996 SP - 130 EP - 135 VL - 178 IS - 1 SN - 0021-9193, 0021-9193 KW - RNA, Bacterial KW - 0 KW - RNA, Messenger KW - Rec A Recombinases KW - EC 2.7.7.- KW - Index Medicus KW - Ultraviolet Rays KW - Transformation, Bacterial KW - RNA, Bacterial -- biosynthesis KW - Gamma Rays KW - DNA Damage KW - Shigella flexneri -- genetics KW - Radiation Tolerance KW - Escherichia coli -- genetics KW - Genetic Vectors -- genetics KW - Species Specificity KW - RNA, Messenger -- biosynthesis KW - DNA Replication KW - Rec A Recombinases -- genetics KW - Rec A Recombinases -- biosynthesis KW - Micrococcus -- radiation effects KW - Genes, Bacterial -- genetics KW - Micrococcus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77928777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Expression+of+recA+in+Deinococcus+radiodurans.&rft.au=Carroll%2C+J+D%3BDaly%2C+M+J%3BMinton%2C+K+W&rft.aulast=Carroll&rft.aufirst=J&rft.date=1996-01-01&rft.volume=178&rft.issue=1&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-02-20 N1 - Date created - 1996-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 1975 Feb;121(2):422-8 [1112771] J Bacteriol. 1994 Dec;176(24):7506-15 [8002574] J Bacteriol. 1995 Jan;177(1):86-93 [7798154] J Mol Biol. 1976 Mar 15;101(4):459-77 [57241] Genetics. 1979 Oct;93(2):321-43 [395024] J Mol Biol. 1983 Jul 5;167(3):539-60 [6308264] Microbiol Rev. 1988 Mar;52(1):1-28 [3280962] J Bacteriol. 1988 May;170(5):2126-35 [2834326] Plasmid. 1989 Sep;22(2):132-42 [2695951] J Bacteriol. 1990 Jun;172(6):2955-61 [2160933] Crit Rev Biochem Mol Biol. 1990;25(6):415-56 [2292186] J Bacteriol. 1991 Oct;173(19):6110-7 [1655698] Plasmid. 1992 Nov;28(3):258-61 [1461940] J Bacteriol. 1993 Jun;175(11):3581-90 [8501062] J Bacteriol. 1993 Sep;175(18):5907-15 [7690748] Mutat Res. 1994 Jan;314(1):87-97 [7504195] J Bacteriol. 1994 Apr;176(7):1807-12 [8144445] Gene. 1994 Apr 8;141(1):31-7 [8163172] J Bacteriol. 1994 Jun;176(12):3508-17 [8206827] Mol Microbiol. 1994 Jul;13(1):9-15 [7984097] J Bacteriol. 1971 Mar;105(3):976-83 [4929286] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tax Incentives for Corporate Giving Programs: What Measures Increase Funds Available? AN - 61580742; 199703785 AB - Examines financial implications for various types of corporate giving through a discussion of tax rates & deductions, & presents a model that considers the cost-effectiveness of giving through a foundation rather than directly. It is asserted that the financial aspects of giving play a large role in determining corporate executives' choice of gifts. It is concluded that the success of fund-raising in the social services depends on the management of fund-raising programs, social workers should understand difference in giving incentives when approaching corporations & foundations, & nonprofit agencies must remain current on tax legislation changes that would affect corporate motivation. 1 Table, 19 References. Adapted from the source document. JF - Administration in Social Work AU - Webb, Natalie J AD - DRMI Naval Postgraduate School, 1522 Cunningham Rd Monterey CA 93943 Y1 - 1996///0, PY - 1996 DA - 0, 1996 SP - 39 EP - 56 VL - 20 IS - 3 SN - 0364-3107, 0364-3107 KW - corporate giving programs, tax incentives, foundation-based giving model, social service fund-raising implications KW - Taxation KW - Philanthropy KW - Corporations KW - Contributions (Donations) KW - Social Services KW - Incentives KW - Fund Raising KW - article KW - 6130: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61580742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+in+Social+Work&rft.atitle=Tax+Incentives+for+Corporate+Giving+Programs%3A+What+Measures+Increase+Funds+Available%3F&rft.au=Webb%2C+Natalie+J&rft.aulast=Webb&rft.aufirst=Natalie&rft.date=1996-01-01&rft.volume=20&rft.issue=3&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Administration+in+Social+Work&rft.issn=03643107&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Contributions (Donations); Social Services; Fund Raising; Corporations; Incentives; Taxation; Philanthropy ER - TY - JOUR T1 - Instability and topographic steering effects for dense bottom plumes on continental shelves and slopes in polar oceans AN - 52700619; 1997-054495 JF - Eos, Transactions, American Geophysical Union AU - Lin, Jiang AU - Garwood, Roland W AU - Anonymous Y1 - 1996/01// PY - 1996 DA - January 1996 SP - 106 EP - 107 PB - American Geophysical Union, Washington, DC VL - 77 IS - 3, Suppl. SN - 0096-3941, 0096-3941 KW - currents KW - polar regions KW - plumes KW - ocean circulation KW - continental slope KW - numerical models KW - three-dimensional models KW - Antarctic Ocean KW - data processing KW - bottom currents KW - ocean currents KW - submarine canyons KW - topography KW - bottom features KW - digital simulation KW - Arctic Ocean KW - continental shelf KW - ocean floors KW - mid-ocean ridges KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52700619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Instability+and+topographic+steering+effects+for+dense+bottom+plumes+on+continental+shelves+and+slopes+in+polar+oceans&rft.au=Lin%2C+Jiang%3BGarwood%2C+Roland+W%3BAnonymous&rft.aulast=Lin&rft.aufirst=Jiang&rft.date=1996-01-01&rft.volume=77&rft.issue=3%2C+Suppl.&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union; American Society of Limnology and Oceanography; 1996 ocean sciences meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Antarctic Ocean; Arctic Ocean; bottom currents; bottom features; continental shelf; continental slope; currents; data processing; digital simulation; mid-ocean ridges; numerical models; ocean circulation; ocean currents; ocean floors; plumes; polar regions; submarine canyons; three-dimensional models; topography ER - TY - JOUR T1 - Use of the Social Services for Mental Health Purposes in a Rural and an Urban Area in Norway AN - 1761705481; 199803176 AB - Analysis of help seeking addressed to social services in two different areas of Norway, the rural Lofoten region in northern Norway & an urban borough of Oslo, shows that more people seek help for mental health problems from social workers than from mental health professionals. Seeking help from a social worker for mental health purposes is often done in conjunction with requesting services for help with economic problems. Social workers' extensive contact with people experiencing psychosocial adversities should be reflected in their training. 5 Tables, 22 References. Adapted from the source document. JF - Social Work & Social Sciences Review AU - Sorgaard, Knut W AU - Sorenson, T AU - Sandanger, I AU - Ingebrigtsen, G AU - Dalgard, O S AD - NPS, NL-8001 Bodo Norway Y1 - 1996///0, PY - 1996 DA - 0, 1996 SP - 186 EP - 197 VL - 6 IS - 3 SN - 0953-5225, 0953-5225 KW - Health Professions KW - Help Seeking Behavior KW - Urban Areas KW - Social Workers KW - Social Work Education KW - Delivery Systems KW - Social Services KW - Mental Health Services KW - Norway KW - Rural Areas KW - article KW - 6142: mental & emotional problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761705481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+%26+Social+Sciences+Review&rft.atitle=Use+of+the+Social+Services+for+Mental+Health+Purposes+in+a+Rural+and+an+Urban+Area+in+Norway&rft.au=Sorgaard%2C+Knut+W%3BSorenson%2C+T%3BSandanger%2C+I%3BIngebrigtsen%2C+G%3BDalgard%2C+O+S&rft.aulast=Sorgaard&rft.aufirst=Knut&rft.date=1996-01-01&rft.volume=6&rft.issue=3&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Social+Work+%26+Social+Sciences+Review&rft.issn=09535225&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mental Health Services; Social Services; Help Seeking Behavior; Social Work Education; Social Workers; Health Professions; Delivery Systems; Norway; Urban Areas; Rural Areas ER - TY - JOUR T1 - Wave energy transformation on natural profiles AN - 17072001; 3894623 AB - A wave energy transformation model, which includes wave breaking within the surf zone described by surface rollers, is developed for randomly varying waves over arbitrary bathymetry. The model includes roller energy gradients in the energy flux balance, and further specifies the dissipation function based on roller theory following Svendsen. Root-mean-square wave heights, Hrms, are found across the surf zone by numerical iteration, and compare well with field data acquired on both barred and near-planar beaches. The model has two free parameters, sigma , the mean angle to vertical of the wave/roller interface roughly representing the type of breaker, and gamma , a measure of breaking wave saturation equal to the ratio of Hrms to local depth. Optimal values of both parameters are chosen by model fitting, and show the model to be insensitive to sigma . Although the model is sensitive to the choice of gamma , values are consistent with field data. The surface roller model behaves similarly to the bore dissipation model of Thornton and Guza for a particular parameter choice, and is used to decrease model dependence to one input parameter, gamma . JF - Coastal Engineering AU - Lippmann, T C AU - Brookins, AH AU - Thornton, E B AD - Department of Oceanography, Naval Postgraduate School, Monterey, CA, USA Y1 - 1996 PY - 1996 DA - 1996 SP - 1 EP - 20 PB - ELSEVIER SCIENCE B.V. VL - 27 IS - 1-2 SN - 0378-3839, 0378-3839 KW - surf zone KW - surface water waves KW - wave breaking KW - waves KW - Water Resources Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - energy transfer KW - mathematical models KW - coastal waters KW - surf KW - energy KW - Q2 09168:Wind waves KW - SW 0870:Erosion and sedimentation KW - O 2020:Hydrodynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17072001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Coastal+Engineering&rft.atitle=Wave+energy+transformation+on+natural+profiles&rft.au=Lippmann%2C+T+C%3BBrookins%2C+AH%3BThornton%2C+E+B&rft.aulast=Lippmann&rft.aufirst=T&rft.date=1996-01-01&rft.volume=27&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Coastal+Engineering&rft.issn=03783839&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - wave breaking; coastal waters; energy transfer; mathematical models; surf; surf zone; surface water waves; energy; waves ER - TY - JOUR T1 - Epidemiology, control and treatment of multidrug-resistant tuberculosis AN - 15663690; 3955829 AB - Multidrug resistance, i.e. resistance to at least isoniazid and rifampicin, is the most severe form of bacterial resistance in tuberculosis existing today. Since the early 1990s, several outbreaks of multidrug-resistant (MDR) tuberculosis have been reported in different regions of the world, as a consequence of inappropriate use of essential antituberculosis drugs. The increased prevalence of chronic cases with MDR tuberculosis in the community multiplies the risk of transmission of MDR bacilli to uninfected subjects and, thus, potentially reduces the effectiveness of existing regimens for the treatment of new cases with severe primary resistance. This paper will discuss 3 important questions that still remain to be answered with regard to MDR tuberculosis: 1. What is the precise prevalence of MDR tuberculosis in different countries? 2. Under programme conditions, is it possible to prevent the occurrence of acquired resistance to isoniazid and rifampicin? 3. Which regimens can cure MDR tuberculosis under programme conditions in developing countries? JF - Drugs AU - Chaulet, P AU - Raviglione, M AU - Bustreo, F AD - GTB-NPS WHO, 20, Ave. Appia, CH 1211, Geneva 27, Switzerland Y1 - 1996 PY - 1996 DA - 1996 SP - 103 EP - 108 VL - 52 IS - S2 SN - 0012-6667, 0012-6667 KW - isoniazid KW - rifampin KW - Microbiology Abstracts B: Bacteriology KW - tuberculosis KW - developing countries KW - prophylaxis KW - drug resistance KW - epidemiology KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15663690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drugs&rft.atitle=Epidemiology%2C+control+and+treatment+of+multidrug-resistant+tuberculosis&rft.au=Chaulet%2C+P%3BRaviglione%2C+M%3BBustreo%2C+F&rft.aulast=Chaulet&rft.aufirst=P&rft.date=1996-01-01&rft.volume=52&rft.issue=S2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Drugs&rft.issn=00126667&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - epidemiology; drug resistance; tuberculosis; prophylaxis; developing countries ER - TY - JOUR T1 - Bed shear stress coefficients for longshore currents over a barred profile AN - 15597856; 3929088 AB - Quantitative estimates are obtained of various terms in the momentum equation governing the mean alongshore flow in the surf zone on a barred beach. A movable sled was instrumented with pressure, current, and wind sensors to measure wave and wind forcing during the Superduck experiment. Mean currents and bottom shear stress at various locations across the surf zone were determined. Particular attention is devoted to precise estimation of the cross-shore gradient of the radiation stress. Wind forcing is found to be a first-order term, along with wave forcing, under certain conditions. Time dependence of the mean longshore current is due to variable wave forcing inside the surf zone as the tide modulates the depth of waves breaking on the bar. Bed shear stress coefficients, determined as a residual of the local alongshore momentum balance, tended to decrease in magnitude shoreward. Mean bed shear stress coefficients and estimated error are 0.004 plus or minus 0.0013, 0.003 plus or minus 0.0006, and 0.001 plus or minus 0.0003 for offshore the bar, on top and immediately in front of the bar, and in the trough. JF - Coastal Engineering AU - Whitford, D J AU - Thornton, E B AD - Oceanography Department, Naval Postgraduate School, Monterey, CA 93943, USA Y1 - 1996 PY - 1996 DA - 1996 SP - 243 EP - 262 PB - ELSEVIER SCIENCE B.V. VL - 27 IS - 3-4 SN - 0378-3839, 0378-3839 KW - sand bars KW - sandbars KW - surf zone KW - waves KW - Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - shear stress KW - longshore currents KW - beaches KW - surf KW - O 2010:Physical Oceanography KW - SW 0870:Erosion and sedimentation KW - Q2 09170:Nearshore dynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15597856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Coastal+Engineering&rft.atitle=Bed+shear+stress+coefficients+for+longshore+currents+over+a+barred+profile&rft.au=Whitford%2C+D+J%3BThornton%2C+E+B&rft.aulast=Whitford&rft.aufirst=D&rft.date=1996-01-01&rft.volume=27&rft.issue=3-4&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Coastal+Engineering&rft.issn=03783839&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - beaches; sand bars; shear stress; longshore currents; surf zone; surf; waves; sandbars ER - TY - JOUR T1 - Bar/trough generation on a natural beach AN - 13637433; 199704186 AB - Bar/trough generation mechanisms were examined and the ability of the Bowen/Bailard model to predict sediment transport from velocity measurements were evaluated from experimental data obtained on a beach at a U.S. Army research station. Measurements were obtained from a cross-shore array of 9 electromagnetic current meters spanning the surf zone and from daily bathymetric surveys over 10 d. The model simulated bed and suspended load transport separately based on various velocity measurements. To determine the relative importance of transport mechanisms, the velocities were partitioned into 2 classes: mean currents, low frequency infra-gravity and shear instabilities; high frequency short waves and turbulence. Tidal signatures were apparent in all modes of transport. Predicted transport rates were integrated and compared with daily cross-shore bathymetric profiles. Suspended load terms were about 10 times greater than bed load terms owing to the low fall velocity of the fine-grain sand within the surf zone. The dominant mechanism for bar formation was the mobilization of sediments by strong longshore current and incident short waves within the surf zone followed by sediment transportation. The model correctly predicted the first-order movement of the bar during storms but underpredicted trough development and did not always perform adequately during mild wave conditions. There are 34 references. JF - Journal of Geophysical Research AU - Thornton, E B AU - Humiston, R T AU - Birkemeier, W AD - Naval Postgraduate School, Monterey, Calif. Y1 - 1996 PY - 1996 DA - 1996 SP - 12097 EP - 12110 VL - 101 IS - C5 KW - Modelling (-general-) KW - Signature KW - Surf KW - Suspended KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13637433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Bar%2Ftrough+generation+on+a+natural+beach&rft.au=Thornton%2C+E+B%3BHumiston%2C+R+T%3BBirkemeier%2C+W&rft.aulast=Thornton&rft.aufirst=E&rft.date=1996-01-01&rft.volume=101&rft.issue=C5&rft.spage=12097&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Theoretical. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Experimental, numerical and analytical models of mantle starting plumes AN - 50075719; 1996-011411 AB - The results of a combined experimental, numerical and analytical investigation of starting thermal plumes are described, to obtain a better perspective on plumes within the Earth's mantle. Thermal plumes were generated experimentally in a tank of corn syrup by means of an electrical heater. Viscosity ratios of 400, 30 000, and 10 (super 8) were generated by varying the temperature of the tank. Plumes for the smaller ratios had the traditional "balloon-on-a-string" shape, but that at the highest ratio had a novel morphology. The plume heads in the first two cases were observed to rise at roughly a constant speed, in contrast to most previous studies which found the plume heads to accelerate. Loss of buoyancy from the plume head owing to heat loss is believed to be responsible for this difference. Starting plumes were simulated numerically using an axisymmetric, finite-element code to solve the Boussinesq equations at finite Prandtl numbers. The constant rise speed observed experimentally was confirmed by the numerical simulation for the viscosity ratios of 400 and 30 000, but numerical instability prevented simulation of the case with a viscosity ratio of 10 (super 8) . There was very good agreement between the experimental and numerical rise speeds. An analytical model was developed which reduces to previous models in limiting cases. This parameterization gives better agreement with the experimental and numerical results than does any previous model. JF - Physics of the Earth and Planetary Interiors AU - Coulliette, D L AU - Loper, D E Y1 - 1995/12// PY - 1995 DA - December 1995 SP - 143 EP - 167 PB - Elsevier, Amsterdam VL - 92 IS - 3-4 SN - 0031-9201, 0031-9201 KW - methods KW - experimental studies KW - numerical models KW - mantle KW - equations KW - simulation KW - temperature KW - physical properties KW - plate tectonics KW - errors KW - factors KW - viscosity KW - quantitative analysis KW - mathematical methods KW - velocity KW - mantle plumes KW - 18:Solid-earth geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50075719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physics+of+the+Earth+and+Planetary+Interiors&rft.atitle=Experimental%2C+numerical+and+analytical+models+of+mantle+starting+plumes&rft.au=Coulliette%2C+D+L%3BLoper%2C+D+E&rft.aulast=Coulliette&rft.aufirst=D&rft.date=1995-12-01&rft.volume=92&rft.issue=3-4&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Physics+of+the+Earth+and+Planetary+Interiors&rft.issn=00319201&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00319201 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 1996-01-01 N1 - Number of references - 38 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PEPIAM N1 - SubjectsTermNotLitGenreText - equations; errors; experimental studies; factors; mantle; mantle plumes; mathematical methods; methods; numerical models; physical properties; plate tectonics; quantitative analysis; simulation; temperature; velocity; viscosity ER - TY - JOUR T1 - Protective effect of cell-permeable ceramide analogs against modeccin, ricin, Pseudomonas toxin, and diphtheria toxin. AN - 77622295; 7589233 AB - We investigated the effects of various ceramide (Cer) analogs and related sphingolipids on the cytotoxicities of modeccin, ricin, Pseudomonas toxin, and diphtheria toxin in various cell lines. The most pronounced protective effect by C6Cer, a short-chain cell-permeable Cer analog, was observed in modeccin cytotoxicity in Vero, BER-40, and MDCK cells, whereas the cytotoxicity of diphtheria toxin was not affected by any of the ceramide analogs tested. C6Cer did not affect the binding and internalization of ricin and modeccin in Vero and BER-40 cells. C2Cer and C8Cer also protected against modeccin cytotoxicity, albeit less effectively than C6Cer. However, related sphingolipids including sphingosine, sphingomyelin, lactosylceramide, C18Cer (the naturally occurring ceramide), and dihydro C6Cer had no effect. A correlation was found between the ability of ceramides to inhibit bulk protein secretion and the inhibition of modeccin cytotoxicity by ceramides. Among Cer analogs tested, C6Cer, the most potent inhibitor of modeccin cytotoxicity, strongly inhibited bulk protein secretion in Vero, BER-40, and MDCK cells. PtK1 cells, which were not protected by ceramides against toxins, were resistant to ceramide-induced inhibition of bulk protein secretion. These results confirm that Cer may modulate the intracellular transport of proteins through the Golgi complex. Such Cer-sensitive processes may be involved in the intoxication of cells by plant and bacterial toxins, especially modeccin. JF - Experimental cell research AU - Oda, T AU - Wu, H C AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1995/11// PY - 1995 DA - November 1995 SP - 1 EP - 10 VL - 221 IS - 1 SN - 0014-4827, 0014-4827 KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Toxins KW - Ceramides KW - Cyclopentanes KW - Diphtheria Toxin KW - Lectins KW - Plant Lectins KW - Proteins KW - Ribosome Inactivating Proteins, Type 2 KW - Brefeldin A KW - 20350-15-6 KW - modeccin KW - 65988-88-7 KW - Ricin KW - 9009-86-3 KW - Protein Kinases KW - EC 2.7.- KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Sphingomyelin Phosphodiesterase KW - EC 3.1.4.12 KW - Index Medicus KW - Proteins -- secretion KW - Animals KW - Phosphoprotein Phosphatases -- pharmacology KW - Anti-Bacterial Agents -- pharmacology KW - Cell Line -- physiology KW - Protein Kinases -- pharmacology KW - Sphingomyelin Phosphodiesterase -- pharmacology KW - Protein Binding -- physiology KW - Cyclopentanes -- pharmacology KW - Cell Membrane Permeability -- drug effects KW - Cercopithecus aethiops KW - Dogs KW - Kidney -- cytology KW - Vero Cells -- physiology KW - Pseudomonas -- chemistry KW - Ricin -- toxicity KW - Bacterial Toxins -- metabolism KW - Ricin -- metabolism KW - Diphtheria Toxin -- toxicity KW - Bacterial Toxins -- toxicity KW - Ceramides -- pharmacokinetics KW - Lectins -- toxicity KW - Lectins -- metabolism KW - Ceramides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77622295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Protective+effect+of+cell-permeable+ceramide+analogs+against+modeccin%2C+ricin%2C+Pseudomonas+toxin%2C+and+diphtheria+toxin.&rft.au=Oda%2C+T%3BWu%2C+H+C&rft.aulast=Oda&rft.aufirst=T&rft.date=1995-11-01&rft.volume=221&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-12-14 N1 - Date created - 1995-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bottom shear stresses derived from mean longshore current profiles during Duck94 AN - 52109158; 2002-038576 JF - Eos, Transactions, American Geophysical Union AU - Thornton, E AU - Stanton, T AU - Garcez Faria, A AU - Anonymous Y1 - 1995/11// PY - 1995 DA - November 1995 SP - 285 EP - 286 PB - American Geophysical Union, Washington, DC VL - 76 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - currents KW - waves KW - time factor KW - shear stress KW - roughness KW - surveys KW - coastal environment KW - ocean floors KW - oceanography KW - measurement KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52109158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Bottom+shear+stresses+derived+from+mean+longshore+current+profiles+during+Duck94&rft.au=Thornton%2C+E%3BStanton%2C+T%3BGarcez+Faria%2C+A%3BAnonymous&rft.aulast=Thornton&rft.aufirst=E&rft.date=1995-11-01&rft.volume=76&rft.issue=46%2C+Suppl.&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1995 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - coastal environment; currents; measurement; ocean floors; oceanography; roughness; shear stress; surveys; time factor; waves ER - TY - JOUR T1 - Role of dietary salt in hypertension. AN - 77740328; 8522721 AB - Hypertension is the most common chronic disease in the United States and, untreated, results in disability or death due to stroke, heart failure or kidney failure. Fortunately the results of hypertension can be avoided to a large extent by proper treatment. One treatment which is effective in some cases is the restriction of dietary NaCl intake. This review considers the role of dietary NaCl in the genesis, therapy and prevention of hypertension. Most people can eat as much NaCl as they like; they have good kidneys which, within about 24 hours, excrete the NaCl as fast as it is taken in and nothing happens to blood pressure. A few, especially those with kidney disease, do not excrete it as fast as it is taken in and blood pressure rises. They are "salt sensitive". Once hypertension is established, the proportion who are "NaCl sensitive" is much higher. About 60% of people with hypertension respond to a high NaCl intake with a rise in pressure and to NaCl restriction with a fall in pressure and reduction in the need for antihypertensive medication. These are the same people that respond to diuretics with a fall in blood pressure. Many are black and elderly and have low plasma renin activity (low-renin hypertension) but some have normal or high plasma renin activity (normal or high-renin hypertension). Evidence suggests that very early they have a subtle kidney defect which causes them to excrete NaCl and water more slowly, e.g., even before they become hypertensive, black and elderly subjects excrete intravenously administered NaCl more slowly than white and young subjects. How does NaCl retention raise blood pressure? One possibility is that the NaCl retention causes water retention which releases a digitalis-like substance that increases the contractile activity of heart and blood vessels. Another is that the sodium itself penetrates the vascular smooth muscle cell, causing it to contract. "Salt sensitive" hypertension also responds to increased potassium and calcium intakes, perhaps in part because they increase NaCl urinary excretion. JF - Journal of the American College of Nutrition AU - Haddy, F J AU - Pamnani, M B AD - Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1995/10// PY - 1995 DA - October 1995 SP - 428 EP - 438 VL - 14 IS - 5 SN - 0731-5724, 0731-5724 KW - Calcium, Dietary KW - 0 KW - Potassium, Dietary KW - Sodium Chloride, Dietary KW - Index Medicus KW - Diet, Sodium-Restricted KW - Age Factors KW - Risk Factors KW - Humans KW - Disease Models, Animal KW - Aged KW - Hypertension -- chemically induced KW - Sodium Chloride, Dietary -- adverse effects KW - Sodium Chloride, Dietary -- metabolism KW - Hypertension -- prevention & control KW - African Continental Ancestry Group KW - Hypertension -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77740328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Nutrition&rft.atitle=Role+of+dietary+salt+in+hypertension.&rft.au=Haddy%2C+F+J%3BPamnani%2C+M+B&rft.aulast=Haddy&rft.aufirst=F&rft.date=1995-10-01&rft.volume=14&rft.issue=5&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Nutrition&rft.issn=07315724&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-01-24 N1 - Date created - 1996-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A trichloroethylene risk assessment using a Monte Carlo analysis of parameter uncertainty in conjunction with physiologically-based pharmacokinetic modeling. AN - 77735279; 7501875 AB - A Monte Carlo simulation is incorporated into a risk assessment for trichloroethylene (TCE) using physiologically-based pharmacokinetic (PBPK) modeling coupled with the linearized multistage model to derive human carcinogenic risk extrapolations. The Monte Carlo technique incorporates physiological parameter variability to produce a statistically derived range of risk estimates which quantifies specific uncertainties associated with PBPK risk assessment approaches. Both inhalation and ingestion exposure routes are addressed. Simulated exposure scenarios were consistent with those used by the Environmental Protection Agency (EPA) in their TCE risk assessment. Mean values of physiological parameters were gathered from the literature for both mice (carcinogenic bioassay subjects) and for humans. Realistic physiological value distributions were assumed using existing data on variability. Mouse cancer bioassay data were correlated to total TCE metabolized and area-under-the-curve (blood concentration) trichloroacetic acid (TCA) as determined by a mouse PBPK model. These internal dose metrics were used in a linearized multistage model analysis to determine dose metric values corresponding to 10(-6) lifetime excess cancer risk. Using a human PBPK model, these metabolized doses were then extrapolated to equivalent human exposures (inhalation and ingestion). The Monte Carlo iterations with varying mouse and human physiological parameters produced a range of human exposure concentrations producing a 10(-6) risk. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Cronin, W J AU - Oswald, E J AU - Shelley, M L AU - Fisher, J W AU - Flemming, C D AD - Air Force Institute of Technology, Department of Engineering and Environmental Management, Wright-Patterson Air Force Base, Ohio 45433, USA. Y1 - 1995/10// PY - 1995 DA - October 1995 SP - 555 EP - 565 VL - 15 IS - 5 SN - 0272-4332, 0272-4332 KW - Anesthetics, Inhalation KW - 0 KW - Carcinogens KW - Trichloroethylene KW - 290YE8AR51 KW - Index Medicus KW - United States KW - Administration, Oral KW - Animals KW - United States Environmental Protection Agency KW - Computer Simulation KW - Dose-Response Relationship, Drug KW - Humans KW - Linear Models KW - Mice KW - Neoplasms, Experimental -- chemically induced KW - Neoplasms -- chemically induced KW - Environmental Exposure KW - Administration, Inhalation KW - Female KW - Male KW - Anesthetics, Inhalation -- pharmacokinetics KW - Trichloroethylene -- metabolism KW - Carcinogens -- pharmacokinetics KW - Trichloroethylene -- adverse effects KW - Monte Carlo Method KW - Models, Biological KW - Risk Assessment KW - Anesthetics, Inhalation -- adverse effects KW - Carcinogens -- metabolism KW - Trichloroethylene -- pharmacokinetics KW - Trichloroethylene -- blood KW - Anesthetics, Inhalation -- metabolism KW - Models, Chemical KW - Anesthetics, Inhalation -- blood KW - Carcinogens -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77735279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=A+trichloroethylene+risk+assessment+using+a+Monte+Carlo+analysis+of+parameter+uncertainty+in+conjunction+with+physiologically-based+pharmacokinetic+modeling.&rft.au=Cronin%2C+W+J%3BOswald%2C+E+J%3BShelley%2C+M+L%3BFisher%2C+J+W%3BFlemming%2C+C+D&rft.aulast=Cronin&rft.aufirst=W&rft.date=1995-10-01&rft.volume=15&rft.issue=5&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-01-17 N1 - Date created - 1996-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Opioid-induced increase in [Ca2+]i in ND8-47 neuroblastoma x dorsal root ganglion hybrid cells is mediated through G protein-coupled delta-opioid receptors and desensitized by chronic exposure to opioid. AN - 77535228; 7561856 AB - delta-Receptor agonists induce a concentration-dependent increase in intracellular calcium concentration ([Ca2+]i) in ND8-47 cells by activating dihydropyridine-sensitive Ca2+ channels. The role of G proteins in transducing the opioid effect has been studied. Pretreatment of cells with pertussis toxin (100 ng/ml, 24 h) almost completely blocked [D-Ser2,Leu5]enkephalin-Thr (DSLET)-induced increase in [Ca2+]i. Cholera toxin (10 nM, 24 h) had no effect on DSLET-induced response. Pretreatment of the cells with 1 microM DSLET for 1 h resulted in a 30% inhibition of DSLET-induced increase in [Ca2+]i and a 78% inhibition after exposure for 24 h. After 1 h of exposure to DSLET, there was a decrease in agonist affinity with no significant changes in receptor density. Cells exposed to 1 microM DSLET for 24 h demonstrate a nearly 90% decrease in [3H]diprenorphine binding, with a decrease in affinity for agonist at the remaining binding sites. G protein subunits alpha i2, alpha i3, alpha s, and alpha q were detected in ND8-47 cell membranes by western blot; alpha o and alpha i1 were not present. Chronic DSLET treatment had no significant effect on the quantity of each of the alpha-subunits. These results suggest that the DSLET-induced increase in [Ca2+]i mediated through pertussis toxin-sensitive G proteins (probably Gi2 or Gi3) and the attenuation of this response in chronically treated cells is associated with a relatively rapid reduction in receptor affinity to DSLET and a slow reduction in receptor density. JF - Journal of neurochemistry AU - Tang, T AU - Kiang, J G AU - Cote, T AU - Cox, B M AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 21814-4799, USA. Y1 - 1995/10// PY - 1995 DA - October 1995 SP - 1612 EP - 1621 VL - 65 IS - 4 SN - 0022-3042, 0022-3042 KW - Calcium Channels KW - 0 KW - Dihydropyridines KW - Narcotics KW - Receptors, Opioid KW - Receptors, Opioid, delta KW - Virulence Factors, Bordetella KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - Enkephalin, Leucine KW - 58822-25-6 KW - enkephalin, Ser(2), Leu(5), Thr(6)- KW - 75644-90-5 KW - Cholera Toxin KW - 9012-63-9 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Neuroblastoma -- pathology KW - Osmolar Concentration KW - Calcium Channels -- metabolism KW - Dihydropyridines -- pharmacology KW - Receptors, Opioid -- metabolism KW - Cholera Toxin -- pharmacology KW - Enkephalin, Leucine -- pharmacology KW - Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology KW - Ganglia, Spinal -- cytology KW - Virulence Factors, Bordetella -- pharmacology KW - Tumor Cells, Cultured KW - Calcium Channels -- drug effects KW - Enkephalin, Leucine -- analogs & derivatives KW - Time Factors KW - Hybrid Cells -- metabolism KW - Calcium -- metabolism KW - GTP-Binding Proteins -- metabolism KW - Receptors, Opioid, delta -- physiology KW - Intracellular Membranes -- metabolism KW - Narcotics -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77535228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Opioid-induced+increase+in+%5BCa2%2B%5Di+in+ND8-47+neuroblastoma+x+dorsal+root+ganglion+hybrid+cells+is+mediated+through+G+protein-coupled+delta-opioid+receptors+and+desensitized+by+chronic+exposure+to+opioid.&rft.au=Tang%2C+T%3BKiang%2C+J+G%3BCote%2C+T%3BCox%2C+B+M&rft.aulast=Tang&rft.aufirst=T&rft.date=1995-10-01&rft.volume=65&rft.issue=4&rft.spage=1612&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-10-25 N1 - Date created - 1995-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Central Role of Discourse in Large-Scale Change: A Social Construction Perspective AN - 61418740; 9600611 AB - Reconceptualizes the change process from a rational planning perspective to an interpretive perspective emphasizing the social construction of meaning. Discourse is viewed as the core of the change process through which our basic assumptions about organizing are created, sustained, & transformed. To illustrate the dynamics of meaning systems, examples are provided of organizations shifting from mechanistic assumptions to become more adaptive, responsive, quality-oriented organizations. Implications for researchers & managers are included. 38 References. Adapted from the source document. JF - The Journal of Applied Behavioral Science AU - Barrett, Frank J AU - Thomas, Gail Fann AU - Hocevar, Susan P AD - Dept Systems Management Naval Postgraduate School, Monterey CA 93943 Y1 - 1995/09// PY - 1995 DA - September 1995 SP - 352 EP - 372 VL - 31 IS - 3 SN - 0021-8863, 0021-8863 KW - large-scale organizational change, social construction of meaning, discourse role KW - Social Constructionism KW - Discourse KW - Organizational Change KW - article KW - 0624: complex organization; bureaucratic structure/organizational sociology KW - 1330: sociology of language and the arts; sociology of language/sociolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61418740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Applied+Behavioral+Science&rft.atitle=The+Central+Role+of+Discourse+in+Large-Scale+Change%3A+A+Social+Construction+Perspective&rft.au=Barrett%2C+Frank+J%3BThomas%2C+Gail+Fann%3BHocevar%2C+Susan+P&rft.aulast=Barrett&rft.aufirst=Frank&rft.date=1995-09-01&rft.volume=31&rft.issue=3&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Applied+Behavioral+Science&rft.issn=00218863&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JABHAP N1 - SubjectsTermNotLitGenreText - Organizational Change; Discourse; Social Constructionism ER - TY - JOUR T1 - Modeling ocean circulation AN - 50095807; 1995-064454 JF - Science AU - Semtner, Albert J A2 - Hanson, Brooks A2 - Appenzeller, Tim Y1 - 1995/09// PY - 1995 DA - September 1995 SP - 1379 EP - 1385 PB - American Association for the Advancement of Science, Washington, DC VL - 269 IS - 5229 SN - 0036-8075, 0036-8075 KW - ocean circulation KW - Quaternary KW - numerical models KW - geologic hazards KW - data processing KW - paleo-oceanography KW - paleocirculation KW - global change KW - fluid dynamics KW - Holocene KW - oceanography KW - Cenozoic KW - digital simulation KW - climate effects KW - upper Holocene KW - world ocean KW - remote sensing KW - 24:Quaternary geology KW - 22:Environmental geology KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50095807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=Modeling+ocean+circulation&rft.au=Semtner%2C+Albert+J&rft.aulast=Semtner&rft.aufirst=Albert&rft.date=1995-09-01&rft.volume=269&rft.issue=5229&rft.spage=1379&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/ L2 - http://www.sciencemag.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - Number of references - 35 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch maps N1 - Last updated - 2012-06-07 N1 - CODEN - SCIEAS N1 - SubjectsTermNotLitGenreText - Cenozoic; climate effects; data processing; digital simulation; fluid dynamics; geologic hazards; global change; Holocene; numerical models; ocean circulation; oceanography; paleo-oceanography; paleocirculation; Quaternary; remote sensing; upper Holocene; world ocean ER - TY - JOUR T1 - Ilimaquinone inhibits the cytotoxicities of ricin, diphtheria toxin, and other protein toxins in Vero cells. AN - 77456753; 7543857 AB - Ilimaquinone (IQ), a metabolite from sea sponges, has been shown to cause the breakdown of Golgi membranes into small vesicular structure and to inhibit protein transport without eliciting the retrograde transport of the Golgi enzymes to the endoplasmic reticulum [P. A. Takizawa, J. K. Yucel, B. Viet, D. J. Faulkner, T. Deerinck, G. Soto, M. Ellismann, and V. Malhotra, Cell (1993) 73, 1079-1090]. We have found that incubation of Vero cells with IQ inhibited the cytotoxicity of ricin in a dose-dependent manner. The inhibition was reversed upon the removal of IQ. Neither binding and internalization of 125I-ricin nor the translocation of ricin to the cytosol was affected by IQ. However, IQ significantly inhibited the recycling and degradation of internalized 125I-ricin. Preincubation with IQ also prevented the enhancement of ricin cytotoxicity by NH4Cl or nigericin. The inhibition of ricin cytotoxicity by IQ was observed in the presence of cycloheximide, indicating that de novo protein synthesis is not required for IQ-mediated protection of Vero cells from ricin cytotoxicity. In contrast to perinuclear distribution of TRITC-labeled ricin in Vero cells, TRITC-ricin appeared in numerous small vesicles dispersed throughout the cytoplasm in IQ-treated Vero cells. Double labeling with C6-NBD-ceramide and TRITC-labeled ricin showed that these ricin-containing vesicles were distinct from the IQ-induced breakdown product of the Golgi membranes. Like brefeldin A (BFA), IQ inhibited the cytotoxicities of abrin, modeccin, Pseudomonas toxin, and Shiga-like toxin in Vero cells. Unlike BFA, IQ also inhibited the cytotoxicity of diphtheria toxin (DT). Inhibition of DT cytotoxicity was the consequence of a decreased specific binding of the toxin in the IQ-treated cells. JF - Experimental cell research AU - Nambiar, M P AU - Wu, H C AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1995/08// PY - 1995 DA - August 1995 SP - 671 EP - 678 VL - 219 IS - 2 SN - 0014-4827, 0014-4827 KW - Diphtheria Toxin KW - 0 KW - Quinones KW - Reverse Transcriptase Inhibitors KW - illimaquinone KW - 71678-03-0 KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - Protein Biosynthesis KW - Animals KW - Cercopithecus aethiops KW - Vero Cells KW - Cell Death -- drug effects KW - Ricin -- antagonists & inhibitors KW - Diphtheria Toxin -- pharmacology KW - Quinones -- pharmacology KW - Diphtheria Toxin -- antagonists & inhibitors KW - Ricin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77456753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Ilimaquinone+inhibits+the+cytotoxicities+of+ricin%2C+diphtheria+toxin%2C+and+other+protein+toxins+in+Vero+cells.&rft.au=Nambiar%2C+M+P%3BWu%2C+H+C&rft.aulast=Nambiar&rft.aufirst=M&rft.date=1995-08-01&rft.volume=219&rft.issue=2&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-09-18 N1 - Date created - 1995-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The serine/threonine phosphatase inhibitor, calyculin A, inhibits and dissociates macrophage responses to lipopolysaccharide. AN - 77442606; 7636205 AB - LPS-stimulated macrophages (M phi) produce inflammatory mediators that are largely responsible for the pathophysiology associated with septic shock. M phi respond to LPS with rapid protein phosphorylation and dephosphorylation on serine, threonine, and tyrosine residues. If these events are critical for the cellular response to LPS, the kinases and/or phosphatases involved may be vulnerable targets for pharmacologic intervention. Recent studies demonstrated that tyrosine kinase inhibitors block LPS-induced tyrosine phosphorylation of MAP kinases as well as TNF-alpha and IL-1 beta production. To investigate a role for serine/threonine phosphatases, we evaluated the effect of calyculin A, a potent serine/threonine phosphatase inhibitor, on LPS stimulation of murine M phi. Pretreatment of M phi with calyculin A inhibited LPS-induced expression of six immediate-early genes: TNF-alpha, IL-1 beta, IFN-beta, IP-10, IRF-1, and TNFR-2. Calyculin A added 1.5 h after LPS treatment greatly reduced accumulation of IP-10, IRF-1, and TNFR-2 mRNA, but not TNF-alpha, IL-1 beta, and IFN-beta mRNA. Calyculin A, in the absence or presence of LPS, resulted in sustained tyrosine phosphorylation of the MAP kinases. These findings suggest that an "early" serine/threonine phosphatase activity is essential for LPS stimulation of M phi and that the activation of MAP kinases is not sufficient for the induction of these immediate-early genes. The requirement for a "late" phosphatase activity for expression of a subset of LPS-inducible genes dissociates at least two regulatory pathways in LPS signal transduction. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Barber, S A AU - Perera, P Y AU - McNally, R AU - Vogel, S N AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 1995/08/01/ PY - 1995 DA - 1995 Aug 01 SP - 1404 EP - 1410 VL - 155 IS - 3 SN - 0022-1767, 0022-1767 KW - erk-1 KW - erk-2 KW - Cytokines KW - 0 KW - Lipopolysaccharides KW - Oxazoles KW - calyculin A KW - 7D07U14TK3 KW - Calcium-Calmodulin-Dependent Protein Kinases KW - EC 2.7.11.17 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Abridged Index Medicus KW - Index Medicus KW - Protein Processing, Post-Translational -- drug effects KW - Calcium-Calmodulin-Dependent Protein Kinases -- metabolism KW - Animals KW - Cytokines -- genetics KW - Genes, Immediate-Early -- drug effects KW - Cytokines -- biosynthesis KW - Mice, Inbred C3H KW - Mice KW - Female KW - Phosphorylation -- drug effects KW - Phosphoprotein Phosphatases -- antagonists & inhibitors KW - Phosphoprotein Phosphatases -- physiology KW - Oxazoles -- pharmacology KW - Lipopolysaccharides -- pharmacology KW - Signal Transduction -- drug effects KW - Macrophages, Peritoneal -- drug effects KW - Gene Expression Regulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77442606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=The+serine%2Fthreonine+phosphatase+inhibitor%2C+calyculin+A%2C+inhibits+and+dissociates+macrophage+responses+to+lipopolysaccharide.&rft.au=Barber%2C+S+A%3BPerera%2C+P+Y%3BMcNally%2C+R%3BVogel%2C+S+N&rft.aulast=Barber&rft.aufirst=S&rft.date=1995-08-01&rft.volume=155&rft.issue=3&rft.spage=1404&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-09-12 N1 - Date created - 1995-09-12 N1 - Date revised - 2017-01-13 N1 - Gene symbol - erk-1; erk-2 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transient neurologic deficit after spinal anesthesia: local anesthetic maldistribution with pencil point needles? AN - 77407117; 7618722 AB - Recent reports of transient neurologic deficits have raised concern about the potential toxicity of single-dose spinal 5% lidocaine in 7.5% dextrose. Two cases of volunteers who experienced minor local sensory deficits after slow (60 s) injections of 2 mL 5% lidocaine via Whitacre needles are described. One case was a result of a double injection because of a "failed" block. It seemed possible that the neurologic deficit in these cases resulted from neurotoxicity associated with maldistribution of local anesthetic. Using an in vitro spinal model, we investigated drug distribution resulting from injections through side-port spinal needles to determine whether the use of these needles could result in high local concentrations of hyperbaric solutions. A spinal canal model was fabricated using human magnetic resonance measurements. The model was placed in a surgical supine position and filled with lactated Ringer's solution to simulate the specific gravity of cerebral spinal fluid at 22 degrees C. A hyperbaric solution of phthalocyanine blue dye and dextrose (SG 1.042), simulating the anesthetic, was injected through three different needles (27-gauge 4 11/16-in. Whitacre, 25-gauge 3 1/2-in. Whitacre, 25-gauge 3 1/2-in. Quincke). Triplicate injections were done at rapid (2 mL/10 s) and slow (2 mL/60 s) rates, with needle side ports oriented in a sacral and cephalad direction. At slow rates of injection, using 27- or 25-gauge sacrally directed Whitacre needles, injections showed evidence of maldistribution with extrapolated peak sacral lidocaine concentrations reaching 2.0%. In contrast, distribution after slow injection through sacrally directed Quincke needles was uniform.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Anesthesia and analgesia AU - Beardsley, D AU - Holman, S AU - Gantt, R AU - Robinson, R A AU - Lindsey, J AU - Bazaral, M AU - Stewart, S F AU - Stevens, R A AD - Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 1995/08// PY - 1995 DA - August 1995 SP - 314 EP - 320 VL - 81 IS - 2 SN - 0003-2999, 0003-2999 KW - Coloring Agents KW - 0 KW - Indoles KW - Isotonic Solutions KW - Organometallic Compounds KW - copper phthalocyanine KW - 3VEX9T7UT5 KW - Ringer's lactate KW - 8022-63-7 KW - Lidocaine KW - 98PI200987 KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Injections, Spinal -- methods KW - Models, Structural KW - Nerve Block -- adverse effects KW - Humans KW - Tissue Distribution KW - Sacrum KW - Equipment Design KW - Adult KW - Middle Aged KW - Pressure KW - Glucose -- administration & dosage KW - Male KW - Lidocaine -- administration & dosage KW - Anesthesia, Spinal -- instrumentation KW - Lidocaine -- cerebrospinal fluid KW - Spinal Cord -- metabolism KW - Sensation Disorders -- chemically induced KW - Anesthesia, Spinal -- adverse effects KW - Spinal Cord -- drug effects KW - Lidocaine -- adverse effects KW - Needles -- adverse effects KW - Lidocaine -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77407117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Transient+neurologic+deficit+after+spinal+anesthesia%3A+local+anesthetic+maldistribution+with+pencil+point+needles%3F&rft.au=Beardsley%2C+D%3BHolman%2C+S%3BGantt%2C+R%3BRobinson%2C+R+A%3BLindsey%2C+J%3BBazaral%2C+M%3BStewart%2C+S+F%3BStevens%2C+R+A&rft.aulast=Beardsley&rft.aufirst=D&rft.date=1995-08-01&rft.volume=81&rft.issue=2&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-08-24 N1 - Date created - 1995-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Should the audiometric database analysis method (draft ANSI S12.13-1991) for evaluating the effectiveness of hearing conservation programs be accepted as a US national standard?. AN - 85239311; pmid-7548930 AB - The value of audiometric database analysis (ADBA) procedures for evaluating the effectiveness of hearing conservation programs (HCPs) was studied in a population of 82,195 workers. We rated the HCP using four ADBA procedures. Results showed that the HCP ratings ran the gamut from "unacceptable" to "acceptable" from year to year and from procedure to procedure. A mere 7 percent of the total population was eligible for ADBA analysis. This drastically reduced sample size precludes subgroup analyses of even a large cohort and likely could not be applied to the HCPs of most small- and medium-sized businesses. The low levels of agreement observed (weighted kappa = 15%-25%) between the ADBA procedures reflect poor validity. Generalizability of these results would be inappropriate when so few nonrandomly selected individuals contribute to the evaluation. In view of these problems, acceptance of the ADBA method as a national standard may not be warranted. JF - Journal of the American Academy of Audiology AU - Adera, T AU - Gullickson, G M AU - Helfer, T AU - Wang, L AU - Gardner, J W AD - Uniformed Services University of the Health Sciences, Department of Preventive Medicine and Biometrics, Bethesda, Maryland, USA. PY - 1995 SP - 302 EP - 310 VL - 6 IS - 4 SN - 1050-0545, 1050-0545 KW - United States KW - Human KW - Cohort Studies KW - Support, U.S. Gov't, Non-P.H.S. KW - Female KW - Male KW - Audiology KW - Information Systems KW - Hearing KW - Health Promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85239311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Should+the+audiometric+database+analysis+method+%28draft+ANSI+S12.13-1991%29+for+evaluating+the+effectiveness+of+hearing+conservation+programs+be+accepted+as+a+US+national+standard%3F.&rft.au=Adera%2C+T%3BGullickson%2C+G+M%3BHelfer%2C+T%3BWang%2C+L%3BGardner%2C+J+W&rft.aulast=Adera&rft.aufirst=T&rft.date=1995-07-01&rft.volume=6&rft.issue=4&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Religion and HIV: Implications for Research and Intervention AN - 61533193; 9612106 AB - The extant literature suggests that religion may play complex & varied roles in coping with human immunodeficiency virus (HIV). Such patterns were evident in self-administered questionnaire data from a sample of 422 HIV-seropositive military personnel. Findings highlight the ambivalent ties to organized religion noted elsewhere, as well as ethnic, gender, disease stage, & stressor differences in religious coping. The role of religion in interventions for people with HIV must be evaluated further to determine appropriate applications. 1 Table, 46 References. Adapted from the source document. JF - The Journal of Social Issues AU - Jenkins, Richard A AD - Henry M. Jackson Foundation, 1 Taft Court Suite 250 Rockville MD 20850 rjenkins@usuhsb.usuhs.mil Y1 - 1995/07// PY - 1995 DA - July 1995 SP - 131 EP - 144 VL - 51 IS - 2 SN - 0022-4537, 0022-4537 KW - human immunodeficiency virus (HIV) coping, religion's role KW - questionnaire KW - HIV-positive military personnel KW - Religiosity KW - Acquired Immune Deficiency Syndrome KW - Religious Orientations KW - Coping KW - Religious Beliefs KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care KW - 1535: sociology of religion; sociology of religion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61533193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Social+Issues&rft.atitle=Religion+and+HIV%3A+Implications+for+Research+and+Intervention&rft.au=Jenkins%2C+Richard+A&rft.aulast=Jenkins&rft.aufirst=Richard&rft.date=1995-07-01&rft.volume=51&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Social+Issues&rft.issn=00224537&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSISAF N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Coping; Religious Orientations; Religiosity; Religious Beliefs ER - TY - JOUR T1 - Physician interventions in alcoholism--past and present. AN - 77361724; 7596238 AB - Controversy over how physicians could address the public and private agonies inflicted by alcohol-related disorders has remained active throughout American history. Public and professional attention during the past quarter century has focused primarily on the identification and referral for treatment of the alcohol-dependent or alcoholic individual. Recent controlled research into medical intervention has shown that primary care physicians have an important opportunity to reduce the severity of alcohol-related problems at many points along their course and can provide effective care in the office setting. This article describes how these interventions have developed and highlights their importance in the context of recent changes in health care delivery systems. JF - Maryland medical journal (Baltimore, Md. : 1985) AU - Wright, C AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 1995/06// PY - 1995 DA - June 1995 SP - 447 EP - 452 VL - 44 IS - 6 SN - 0886-0572, 0886-0572 KW - Index Medicus KW - History of medicine KW - United States KW - History, 20th Century KW - Humans KW - Adult KW - Alcoholism -- history KW - Alcoholism -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77361724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maryland+medical+journal+%28Baltimore%2C+Md.+%3A+1985%29&rft.atitle=Physician+interventions+in+alcoholism--past+and+present.&rft.au=Wright%2C+C&rft.aulast=Wright&rft.aufirst=C&rft.date=1995-06-01&rft.volume=44&rft.issue=6&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Maryland+medical+journal+%28Baltimore%2C+Md.+%3A+1985%29&rft.issn=08860572&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-07-28 N1 - Date created - 1995-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Desorption kinetics of trichlorethylene from powdered soils AN - 52824456; 1996-055090 JF - Environmental Science & Technology, ES & T AU - Fares, Abdellatif AU - Kindt, Benjamin T AU - LaPuma, Peter AU - Perram, Glen P Y1 - 1995/06// PY - 1995 DA - June 1995 SP - 1564 EP - 1568 PB - American Chemical Society, Washington, DC VL - 29 IS - 6 SN - 0013-936X, 0013-936X KW - limestone KW - chlorinated hydrocarbons KW - desorption KW - unsaturated zone KW - remediation KW - infrared spectra KW - laboratory studies KW - sedimentary rocks KW - halogenated hydrocarbons KW - spectra KW - kinetics KW - soils KW - experimental studies KW - monitoring KW - gaseous phase KW - pollutants KW - physicochemical properties KW - grain size KW - pollution KW - effects KW - volatiles KW - physical properties KW - organic compounds KW - residence time KW - volatile organic compounds KW - trichloroethylene KW - carbonate rocks KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52824456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Desorption+kinetics+of+trichlorethylene+from+powdered+soils&rft.au=Fares%2C+Abdellatif%3BKindt%2C+Benjamin+T%3BLaPuma%2C+Peter%3BPerram%2C+Glen+P&rft.aulast=Fares&rft.aufirst=Abdellatif&rft.date=1995-06-01&rft.volume=29&rft.issue=6&rft.spage=1564&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/ L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 25 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - carbonate rocks; chlorinated hydrocarbons; desorption; effects; experimental studies; gaseous phase; grain size; halogenated hydrocarbons; infrared spectra; kinetics; laboratory studies; limestone; monitoring; organic compounds; physical properties; physicochemical properties; pollutants; pollution; remediation; residence time; sedimentary rocks; soils; spectra; trichloroethylene; unsaturated zone; volatile organic compounds; volatiles ER - TY - JOUR T1 - A model for repair of radiation-induced DNA double-strand breaks in the extreme radiophile Deinococcus radiodurans. AN - 77347620; 7786292 AB - The bacterium Deinococcus (formerly Micrococcus) radiodurans and other members of the eubacterial family Deinococaceae are extremely resistant to ionizing radiation and many other agents that damage DNA. Stationary phase D. radiodurans exposed to 1.0-1.5 Mrad gamma-irradiation sustains > 120 DNA double-strand breaks (dsbs) per chromosome; these dsbs are mended over a period of hours with 100% survival and virtually no mutagenesis. This contrasts with nearly all other organisms in which just a few ionizing radiation induced-dsbs per chromosome are lethal. In this article we present an hypothesis that resistance of D. radiodurans to ionizing radiation and its ability to mend radiation-induced dsbs are due to a special form of redundancy wherein chromosomes exist in pairs, linked to each other by thousands of four-stranded (Holliday) junctions. Thus, a dsb is not a lethal event because the identical undamaged duplex is nearby, providing an accurate repair template. As addressed in this article, much of what is known about D. radiodurans suggests that it is particularly suited for this proposed novel form of DNA repair. JF - BioEssays : news and reviews in molecular, cellular and developmental biology AU - Minton, K W AU - Daly, M J AD - Department of Pathology, F. E. Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 457 EP - 464 VL - 17 IS - 5 SN - 0265-9247, 0265-9247 KW - Index Medicus KW - X-Rays KW - DNA Damage KW - Models, Biological KW - DNA Repair KW - Micrococcus -- radiation effects KW - Micrococcus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77347620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioEssays+%3A+news+and+reviews+in+molecular%2C+cellular+and+developmental+biology&rft.atitle=A+model+for+repair+of+radiation-induced+DNA+double-strand+breaks+in+the+extreme+radiophile+Deinococcus+radiodurans.&rft.au=Minton%2C+K+W%3BDaly%2C+M+J&rft.aulast=Minton&rft.aufirst=K&rft.date=1995-05-01&rft.volume=17&rft.issue=5&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=BioEssays+%3A+news+and+reviews+in+molecular%2C+cellular+and+developmental+biology&rft.issn=02659247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-07-17 N1 - Date created - 1995-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Changes in enteric neural regulation of smooth muscle in a rabbit model of small intestinal inflammation. AN - 77292305; 7762666 AB - In vitro electrophysiological studies of ileal circular muscle from rabbits with ricin-induced inflammation were performed to investigate whether altered neural control or myogenic activity contributes to previously described changes in in vivo myoelectric activity. Ricin treatment increased mean slow-wave amplitude but not frequency or resting membrane potential. Prolonged electrical field stimulation evoked a hyperpolarization during the stimulus train and a depolarization on cessation of stimulation. In the presence of atropine, the depolarization was larger in ricin-treated tissue than in control tissue, showing that ileitis enhanced noncholinergic excitation. The nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester reduced the hyperpolarization in ricin-treated but not in control tissue, suggesting that inflammation increased nitric oxide-mediated inhibition. Substance P desensitization reduced noncholinergic excitation and mean slow-wave amplitude only in ricin-treated tissue, demonstrating that changes in these parameters during inflammation resulted from increased release of, or sensitivity to, tachykinins. These data suggest that acute ileitis alters tachykinin- and nitric oxide-mediated neurotransmission that may affect the normal pattern of ileal motility and/or sensory reflexes. JF - The American journal of physiology AU - Goldhill, J M AU - Sanders, K M AU - Sjogren, R AU - Shea-Donohue, T AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - G823 EP - G830 VL - 268 IS - 5 Pt 1 SN - 0002-9513, 0002-9513 KW - Tachykinins KW - 0 KW - Nitric Oxide KW - 31C4KY9ESH KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - Animals KW - Nitric Oxide -- metabolism KW - Rabbits KW - Parasympathetic Nervous System -- physiopathology KW - Enteric Nervous System -- physiopathology KW - Neural Inhibition KW - Electrophysiology KW - Electric Stimulation KW - Time Factors KW - Tachykinins -- physiology KW - Male KW - Ileum -- innervation KW - Ileitis -- physiopathology KW - Ileitis -- chemically induced KW - Muscle, Smooth -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77292305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Changes+in+enteric+neural+regulation+of+smooth+muscle+in+a+rabbit+model+of+small+intestinal+inflammation.&rft.au=Goldhill%2C+J+M%3BSanders%2C+K+M%3BSjogren%2C+R%3BShea-Donohue%2C+T&rft.aulast=Goldhill&rft.aufirst=J&rft.date=1995-05-01&rft.volume=268&rft.issue=5+Pt+1&rft.spage=G823&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-06-29 N1 - Date created - 1995-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutational analysis of the ganglioside-binding activity of the type II Escherichia coli heat-labile enterotoxin LT-IIb. AN - 77465121; 7651134 AB - The Escherichia coli type II heat-labile enterotoxin LT-IIb IIb consists of a single A polypeptide and five B polypeptides. The A polypeptide is responsible for the toxic activity, and the B polypeptides function to bind the toxin to gangliosides on the surface of the plasma membrane. Previous studies on the related type II enterotoxin LT-IIa demonstrated the importance of threonine (Thr) residues at positions 13, 14, and 34 in the mature B polypeptide for ganglioside GD1bp-binding activity. In this study, we used sitespecific mutagenesis to investigate ganglioside GD1a-binding activity of the B polypeptide of LT-IIb. We determined that Thr-13 and Thr-14 were involved in binding of ganglioside GD1a by the B polypeptides of LT-IIb but that Thr-34 was not essential. Substitution of serine, but not other amino acids, at position 13 or 14 in the B polypeptide of LT-IIb resulted in retention of ganglioside-binding activity equivalent to that of the wild-type enterotoxin, providing strong evidence that the hydroxyl groups of threonine or serine at positions 13 and 14 are important for the ganglioside-binding activity of LT-IIb. Chimeric genes that expressed hybrids of the B polypeptides of LT-IIb and LT-IIa were also constructed, and analysis of the hybrids showed that the specificity of their ganglioside-binding activity was determined by the N-terminal half of the molecule. JF - Molecular microbiology AU - Connell, T D AU - Holmes, R K AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 21 EP - 31 VL - 16 IS - 1 SN - 0950-382X, 0950-382X KW - LT-IIa KW - LT-IIb KW - Antibodies, Monoclonal KW - 0 KW - Bacterial Toxins KW - Enterotoxins KW - Escherichia coli Proteins KW - Gangliosides KW - Recombinant Fusion Proteins KW - heat-labile enterotoxin, E coli KW - Threonine KW - 2ZD004190S KW - Serine KW - 452VLY9402 KW - Index Medicus KW - Transformation, Bacterial KW - Dose-Response Relationship, Drug KW - Amino Acid Sequence KW - Protein Binding KW - Radioimmunoassay KW - Serine -- metabolism KW - Antibodies, Monoclonal -- immunology KW - Mutagenesis, Site-Directed KW - Recombinant Fusion Proteins -- metabolism KW - Antibody Specificity KW - Base Sequence KW - Sequence Alignment KW - Molecular Sequence Data KW - Bacterial Toxins -- genetics KW - Escherichia coli -- metabolism KW - Bacterial Toxins -- metabolism KW - Threonine -- metabolism KW - Enterotoxins -- metabolism KW - Enterotoxins -- biosynthesis KW - Escherichia coli -- genetics KW - Enterotoxins -- genetics KW - Bacterial Toxins -- biosynthesis KW - Gangliosides -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77465121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Mutational+analysis+of+the+ganglioside-binding+activity+of+the+type+II+Escherichia+coli+heat-labile+enterotoxin+LT-IIb.&rft.au=Connell%2C+T+D%3BHolmes%2C+R+K&rft.aulast=Connell&rft.aufirst=T&rft.date=1995-04-01&rft.volume=16&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-09-25 N1 - Date created - 1995-09-25 N1 - Date revised - 2017-01-13 N1 - Gene symbol - LT-IIa; LT-IIb N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk factors for malaria among expatriates living in Kampala, Uganda: the need for adherence to chemoprophylactic regimens. AN - 77191227; 7694960 AB - This investigation was conducted in response to a report of an increased number of malaria cases among United States Embassy personnel in Kampala, Uganda in the spring of 1992. The objectives of the investigation were to determine if an outbreak had occurred, to identify potential risk factors for malaria in this population, and to assess the effectiveness of various chemoprophylactic regimens. The risk of developing malaria during the first half of 1992 was more than six times greater than during the same time period in 1991 (relative risk [RR] = 6.6, 95% confidence interval [CI] = 1.6-27.8) and almost seven times greater than all the previous six years combined (RR = 6.8, 95% CI = 2.9-15.9). In this outbreak, children and young adults less than 20 years of age had more than a three-fold increase in risk (RR = 3.7, 95% CI = 0.7-19.8) than those in the 20-39-year-old age group. African-Americans had a six-fold increased risk compared with Caucasians (RR = 6.0, 95% CI = 1.6-22.7). Those who did not take any drug prophylaxis were 10 times more likely to develop malaria (RR = 10.0, 95% CI = 2.7-37.0) than those who took mefloquine, doxycycline, or chloroquine plus proguanil. In this setting, weekly mefloquine was 82% more effective, and chloroquine plus proguanil was 92% more effective than weekly chloroquine alone. This outbreak underscores the need for compliance with appropriate chemoprophylactic regimens in preventing malaria infection. JF - The American journal of tropical medicine and hygiene AU - Adera, T AU - Wolfe, M S AU - McGuire-Rugh, K AU - Calhoun, N AU - Marum, L AD - Department of Preventive Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 1995/03// PY - 1995 DA - March 1995 SP - 207 EP - 212 VL - 52 IS - 3 SN - 0002-9637, 0002-9637 KW - Antimalarials KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Travel KW - Age Factors KW - Sex Factors KW - Humans KW - Uganda -- epidemiology KW - African Americans KW - Child KW - United States -- ethnology KW - Employment KW - Disease Outbreaks KW - Marital Status KW - Patient Compliance KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Incidence KW - Adolescent KW - Time Factors KW - African Continental Ancestry Group KW - Male KW - Female KW - Insect Control KW - Malaria, Falciparum -- prevention & control KW - Malaria, Falciparum -- ethnology KW - Antimalarials -- adverse effects KW - Malaria, Falciparum -- epidemiology KW - Antimalarials -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77191227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+tropical+medicine+and+hygiene&rft.atitle=Risk+factors+for+malaria+among+expatriates+living+in+Kampala%2C+Uganda%3A+the+need+for+adherence+to+chemoprophylactic+regimens.&rft.au=Adera%2C+T%3BWolfe%2C+M+S%3BMcGuire-Rugh%2C+K%3BCalhoun%2C+N%3BMarum%2C+L&rft.aulast=Adera&rft.aufirst=T&rft.date=1995-03-01&rft.volume=52&rft.issue=3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+tropical+medicine+and+hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-04-25 N1 - Date created - 1995-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Obesity and therapy-related toxicity in patients treated for small-cell lung cancer. AN - 77137437; 7853417 AB - Obese individuals have altered pharmacokinetics for many medications when compared with the non-obese. For the oncologist treating an obese cancer patient, these changes in drug disposition may potentially cause increased therapy-related toxicity. As a consequence, oncologists frequently treat obese patients with dose reductions in an effort to decrease chemotherapy toxicity. However, little clinical data exist to either support or refute this policy. The clinical course of a cohort of patients treated for small-cell lung cancer (SCLC) was evaluated to determine if the obese patients had an increase in therapy-related toxicity. The study sample included 262 patients with histologically confirmed SCLC treated in clinical trials from 1977 through 1993. Before 1986, patients with limited stage SCLC were treated with a cyclophosphamide-based regimen with (n = 47) or without (n = 46) chest radiotherapy. Subsequent patients with limited stage disease (n = 54) received etoposide and cisplatin plus twice-daily chest radiotherapy. Patients with extensive stage SCLC were randomly treated with standard-dose (n = 46) or high-dose etoposide plus cisplatin (n = 44); poor-risk patients with extensive stage disease (n = 25) were assigned to standard dose etoposide plus cisplatin. For all patients, actual body weight was used when determining initial doses of chemotherapy. The measure of relative weight was the body mass index (BMI), which was calculated from the pretreatment height and weight data. The BMI was evaluated both on a continuum and with patients grouped into BMI levels (normal, obese, and severely obese). Toxicity parameters were collected during induction chemotherapy and were compared with the BMI. In addition, the overall survival of the entire cohort was evaluated, with patients divided into different groups based on their BMI level. We performed 170 comparisons between the BMI as a continuum or the BMI level and the 15 toxicity parameters. There were no consistent associations of significance found between increasing BMI or BMI levels and increasing toxicity from therapy. When survival was evaluated, no statistically significant differences were found between the survival of patients within the different BMI levels. In this group of 262 patients with SCLC, obesity at the start of treatment was not associated with increased toxicity from treatment or a shortened survival. No support for empiric chemotherapy dose reductions based on ideal body weight was evident from this study. JF - Journal of the National Cancer Institute AU - Georgiadis, M S AU - Steinberg, S M AU - Hankins, L A AU - Ihde, D C AU - Johnson, B E AD - National Naval Medical Center, Uniformed Services, University of the Health Sciences, Bethesda, Md. Y1 - 1995/03/01/ PY - 1995 DA - 1995 Mar 01 SP - 361 EP - 366 VL - 87 IS - 5 SN - 0027-8874, 0027-8874 KW - Index Medicus KW - Body Weight KW - Obesity, Morbid -- complications KW - Humans KW - Treatment Outcome KW - Retrospective Studies KW - Body Mass Index KW - Male KW - Female KW - Survival Analysis KW - Lung Neoplasms -- complications KW - Carcinoma, Small Cell -- complications KW - Lung Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Carcinoma, Small Cell -- drug therapy KW - Obesity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77137437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Obesity+and+therapy-related+toxicity+in+patients+treated+for+small-cell+lung+cancer.&rft.au=Georgiadis%2C+M+S%3BSteinberg%2C+S+M%3BHankins%2C+L+A%3BIhde%2C+D+C%3BJohnson%2C+B+E&rft.aulast=Georgiadis&rft.aufirst=M&rft.date=1995-03-01&rft.volume=87&rft.issue=5&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-16 N1 - Date created - 1995-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Natl Cancer Inst. 1995 Mar 1;87(5):333-4 [7853411] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ceramide reverses brefeldin A (BFA) resistance in BFA-resistant cell lines. AN - 77158490; 7876158 AB - We have found that C6 ceramide, a cell-permeable ceramide analog, partially restored the brefeldin A (BFA) sensitivity in a BFA-resistant mutant of Vero cells (BER-40) and in the naturally BFA-resistant Madin-Darby canine kidney (MDCK) cells. Incubation of BER-40 and MDCK cells with low concentrations of C6 ceramide resulted in (i) a pronounced increase in BFA cytotoxicity as measured by the inhibition of [3H]thymidine incorporation and the inhibition of colony formation by BFA, (ii) a significant protection by BFA against ricin cytotoxicity, and (iii) an inhibition of bulk protein secretion by BFA in BER-40 and MDCK cells. Related sphingolipids including sphingosine, sphingomyelin, and lactosylceramide and other unrelated lipid second messengers such as arachidonic acid and 1,2-diacylglycerol did not elicit the protection of BER-40 and MDCK cells against ricin cytotoxicity by BFA. C6 ceramide was the most effective among the ceramides with different acyl chain lengths. Interestingly, dihydro-C6 ceramide, which lacks the trans double bond in the sphingoid base, had no effect. On the other hand, C6 ceramide did not enhance BFA sensitivity in BFA-sensitive Vero cells. The LD50 of C6 ceramide were similar in Vero and BER-40 cells. Fluorescence microscopic studies revealed that C6 ceramide induced the redistribution of beta-COP from the Golgi membranes to a more dispersed localization in both BFA-sensitive and BFA-resistant cell lines, mimicking the effect of BFA. Suboptimal concentration of C6 ceramide also restored the effect of BFA on the beta-COP distribution in BER-40 and MDCK cells. These results indicate that C6 ceramide restores the BFA sensitivity in BFA-resistant BER-40 and MDCK cells. JF - The Journal of biological chemistry AU - Oda, T AU - Chen, C H AU - Wu, H C AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1995/02/24/ PY - 1995 DA - 1995 Feb 24 SP - 4088 EP - 4092 VL - 270 IS - 8 SN - 0021-9258, 0021-9258 KW - Antifungal Agents KW - 0 KW - Ceramides KW - Cyclopentanes KW - Sphingolipids KW - Brefeldin A KW - 20350-15-6 KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - Animals KW - Cell Survival -- drug effects KW - Cercopithecus aethiops KW - Dogs KW - Drug Resistance KW - Vero Cells KW - Ricin -- pharmacology KW - Cell Line KW - Sphingolipids -- metabolism KW - Cyclopentanes -- pharmacology KW - Antifungal Agents -- pharmacology KW - Ceramides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77158490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Ceramide+reverses+brefeldin+A+%28BFA%29+resistance+in+BFA-resistant+cell+lines.&rft.au=Oda%2C+T%3BChen%2C+C+H%3BWu%2C+H+C&rft.aulast=Oda&rft.aufirst=T&rft.date=1995-02-24&rft.volume=270&rft.issue=8&rft.spage=4088&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-31 N1 - Date created - 1995-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - PKC activity and protein phosphorylation in regulation of sIg mediated B cell activation. AN - 77143846; 7863266 AB - The inhibitory and stimulatory elements of cellular signalling associated with activation of protein kinase C (PKC) in murine B lymphocytes were investigated by employing two PKC activators with opposing effects on cell proliferation. Being an inhibitor of anti-Ig mediated proliferation, the phorbol ester PDBU induced a more substantial translocation of cytosolic PKC activity than the alkaloid PKC activator indolactam, which enhances anti-Ig mediated B cell proliferation. PDBU and indolactam were equally effective kinase activators, as determined by 32P incorporation of the substrate proteins. Concentrations of indolactam which induced an inhibition of anti-Ig mediated B cell proliferation also induced a precipitous decline in detergent soluble cellular PKC activity, which was comparable with 1 microM PDBU. The induced phosphoprotein patterns were similar, with an exception of the nuclear envelope protein lamin B, which was prominently phosphorylated by PDBU but not by stimulatory concentrations of indolactam. The enhanced phosphorylation of lamin B was associated with cellular growth arrest: inhibitory concentrations of indolactam induced the phosphorylation of lamin B equal to PDBU, whereas an increased phosphorylation of lamin B was never observed upon stimulation with anti-Ig. Together, inhibition of anti-Ig mediated B cell proliferation was related to down-regulation of cytoplasmic PKC and induction of nuclear PKC-dependent phosphorylation. JF - Scandinavian journal of immunology AU - Lindsberg, M L AU - Feuerstein, N AU - Balapure, A K AU - Mond, J J AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1995/02// PY - 1995 DA - February 1995 SP - 194 EP - 201 VL - 41 IS - 2 SN - 0300-9475, 0300-9475 KW - Indoles KW - 0 KW - Lactams KW - Phosphoproteins KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - indolactam V KW - 8CIY9O1323 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Lymphocyte Activation -- drug effects KW - Animals KW - Electrophoresis, Gel, Two-Dimensional KW - Enzyme Activation -- drug effects KW - Enzyme Activation -- physiology KW - Mice KW - Mice, Inbred DBA KW - Lymphocyte Activation -- physiology KW - Protein Kinase C -- metabolism KW - Protein Kinase C -- drug effects KW - B-Lymphocytes -- drug effects KW - Indoles -- pharmacology KW - B-Lymphocytes -- enzymology KW - B-Lymphocytes -- physiology KW - Lactams -- pharmacology KW - Phosphoproteins -- metabolism KW - Phorbol 12,13-Dibutyrate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77143846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+immunology&rft.atitle=PKC+activity+and+protein+phosphorylation+in+regulation+of+sIg+mediated+B+cell+activation.&rft.au=Lindsberg%2C+M+L%3BFeuerstein%2C+N%3BBalapure%2C+A+K%3BMond%2C+J+J&rft.aulast=Lindsberg&rft.aufirst=M&rft.date=1995-02-01&rft.volume=41&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+immunology&rft.issn=03009475&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-17 N1 - Date created - 1995-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hormone-independent repression of AP-1-inducible collagenase promoter activity by glucocorticoid receptors. AN - 77128344; 7823916 AB - The role of the ligand in glucocorticoid receptor-mediated transactivation and transrepression of gene expression was investigated. Half-maximal transactivation of a mouse mammary tumor virus-chloramphenicol acetyltransferase reporter gene in transfected cells expressing the human glucocorticoid receptor mutant GRL753F, from which the rate of ligand dissociation is four to five times higher than the rate of dissociation from normal receptors, required a 200- to 300-fold-higher concentration of dexamethasone than was required in cells expressing the normal receptor. Immunocytochemical analysis demonstrated that this difference was not the result of a failure of the mutant receptor to accumulate in the nucleus after steroid treatment. In contrast, in cells cotransfected with a reporter gene containing the AP-1-inducible collagenase gene promoter, the concentration of dexamethasone required for 50% transrepression was the same for mutant and normal receptors. Efficient receptor-mediated transrepression was also observed with the double mutant GRL753F/C421Y, in which the first cysteine residue of the proximal zinc finger has been replaced by tyrosine, indicating that neither retention of the ligand nor direct binding of the receptor to DNA is required. RU38486 behaved as a full agonist with respect to transrepression. In addition, receptor-dependent transrepression, but not transactivation, was observed in transfected cells after heat shock in the absence of the ligand. Taken together, these results suggest that unlike transactivation, transrepression of AP-1 activity by the nuclear glucocorticoid receptor is ligand independent. JF - Molecular and cellular biology AU - Liu, W AU - Hillmann, A G AU - Harmon, J M AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1995/02// PY - 1995 DA - February 1995 SP - 1005 EP - 1013 VL - 15 IS - 2 SN - 0270-7306, 0270-7306 KW - DNA-Binding Proteins KW - 0 KW - Ligands KW - Receptors, Glucocorticoid KW - Recombinant Proteins KW - Transcription Factor AP-1 KW - Mifepristone KW - 320T6RNW1F KW - Dexamethasone KW - 7S5I7G3JQL KW - Chloramphenicol O-Acetyltransferase KW - EC 2.3.1.28 KW - Collagenases KW - EC 3.4.24.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Recombinant Proteins -- biosynthesis KW - Chloramphenicol O-Acetyltransferase -- biosynthesis KW - Cell Nucleus -- metabolism KW - Humans KW - Mammary Tumor Virus, Mouse KW - Mifepristone -- pharmacology KW - Mutagenesis, Site-Directed KW - Hot Temperature KW - Transfection KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Cercopithecus aethiops KW - Point Mutation KW - Kidney KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Line KW - Receptors, Glucocorticoid -- biosynthesis KW - Collagenases -- genetics KW - Promoter Regions, Genetic -- drug effects KW - Transcription Factor AP-1 -- metabolism KW - Dexamethasone -- pharmacology KW - DNA-Binding Proteins -- biosynthesis KW - Receptors, Glucocorticoid -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77128344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Hormone-independent+repression+of+AP-1-inducible+collagenase+promoter+activity+by+glucocorticoid+receptors.&rft.au=Liu%2C+W%3BHillmann%2C+A+G%3BHarmon%2C+J+M&rft.aulast=Liu&rft.aufirst=W&rft.date=1995-02-01&rft.volume=15&rft.issue=2&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-16 N1 - Date created - 1995-02-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1991 Jun;11(6):3379-83 [2038339] Biochem Biophys Res Commun. 1991 May 15;176(3):1338-44 [2039516] Science. 1991 Jun 14;252(5012):1546-8 [2047861] Oncogene. 1991 Jul;6(7):1227-34 [1650443] Cancer Res. 1991 Oct 1;51(19):5224-31 [1913646] Biochemistry. 1991 Nov 19;30(46):11140-6 [1932034] Science. 1991 Dec 13;254(5038):1636-9 [1749936] J Biol Chem. 1992 Jan 5;267(1):17-20 [1730584] J Biol Chem. 1992 Feb 15;267(5):2868-71 [1371107] J Biol Chem. 1992 Mar 5;267(7):4281-4 [1537818] EMBO J. 1992 Mar;11(3):1025-33 [1372244] J Biol Chem. 1992 May 15;267(14):9619-21 [1577799] Trends Genet. 1991 Nov-Dec;7(11-12):377-81 [1668190] J Biol Chem. 1992 Sep 5;267(25):17567-73 [1517207] Mol Cell Biol. 1992 Nov;12(11):4960-9 [1406672] Trends Pharmacol Sci. 1992 Aug;13(8):318-23 [1413090] Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11750-4 [1465392] Mol Endocrinol. 1993 May;7(5):631-42 [8316249] Cancer Res. 1993 Sep 1;53(17):4059-65 [8358735] DNA Cell Biol. 1993 Oct;12(8):695-702 [8397827] Endocr Rev. 1993 Oct;14(5):651-8 [8262011] EMBO J. 1993 Dec 15;12(13):5089-96 [8262052] Mol Endocrinol. 1993 Oct;7(10):1266-74 [8264659] J Steroid Biochem Mol Biol. 1993 Dec;47(1-6):55-64 [8274442] Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):752-6 [8290595] J Biol Chem. 1994 Mar 18;269(11):7914-8 [8132510] Steroids. 1994 Feb;59(2):148-52 [8191545] Mol Endocrinol. 1994 Apr;8(4):408-21 [8052262] Mol Endocrinol. 1994 Apr;8(4):422-30 [8052263] EMBO J. 1994 Sep 1;13(17):4087-95 [8076604] J Steroid Biochem Mol Biol. 1993 Sep;46(3):269-79 [9831475] FASEB J. 1991 Apr;5(7):2044-51 [2010057] Cancer Res. 1977 Oct;37(10):3785-91 [269011] J Cell Physiol. 1979 Feb;98(2):267-78 [422656] Proc Natl Acad Sci U S A. 1982 Nov;79(22):6777-81 [6294651] J Biol Chem. 1985 Oct 15;260(23):12398-401 [3900074] J Biol Chem. 1986 Mar 15;261(8):3758-63 [3949789] Genes Dev. 1989 Jun;3(6):760-9 [2744462] J Biol Chem. 1989 Aug 25;264(24):14396-402 [2668288] J Biol Chem. 1989 Aug 25;264(24):14493-7 [2503518] J Exp Med. 1993 Mar 1;177(3):691-8 [8436907] J Clin Invest. 1993 May;91(5):1918-25 [7683692] Mol Cell Biol. 1993 Jun;13(6):3782-91 [8497279] J Biol Chem. 1993 Jul 5;268(19):14026-32 [8314770] Mol Cell Biol. 1989 Dec;9(12):5305-14 [2586521] J Biol Chem. 1990 Feb 15;265(5):2789-96 [2303427] Cell. 1990 Mar 23;60(6):953-62 [2317866] Biochemistry. 1990 Feb 20;29(7):1880-6 [2184891] J Biol Chem. 1990 May 5;265(13):7284-91 [1692020] Mol Endocrinol. 1990 Mar;4(3):455-64 [2160602] J Biol Chem. 1990 Jul 15;265(20):11928-35 [2365707] EMBO J. 1990 Sep;9(9):2827-34 [2118106] Science. 1990 Sep 14;249(4974):1266-72 [2119054] Cell. 1990 Sep 21;62(6):1189-204 [2169351] Cell. 1990 Sep 21;62(6):1205-15 [2169352] Cell. 1990 Sep 21;62(6):1217-26 [2169353] Nature. 1990 Nov 8;348(6297):166-8 [2234079] Biochemistry. 1990 Aug 28;29(34):7958-66 [2261452] J Biol Chem. 1990 Dec 25;265(36):22067-70 [2266108] Science. 1990 Dec 21;250(4988):1740-3 [2176746] J Biol Chem. 1991 Feb 25;266(6):3482-90 [1995612] Cell. 1986 Aug 29;46(5):645-52 [3742595] EMBO J. 1986 Oct;5(10):2513-22 [3780669] Nature. 1986 Dec 18-31;324(6098):688-91 [3025742] J Biol Chem. 1987 May 25;262(15):6986-91 [3294824] Nature. 1987 Aug 13-19;328(6131):624-6 [3614365] J Biol Chem. 1987 Aug 25;262(24):11803-6 [3305495] Mol Cell Biol. 1987 Aug;7(8):2745-52 [3670292] J Biol Chem. 1988 Jan 5;263(1):267-73 [3335498] Mol Cell Biol. 1981 Jun;1(6):512-21 [6965106] J Biol Chem. 1988 Mar 5;263(7):3474-81 [3277971] Dev Biol. 1988 May;127(1):209-19 [2834246] Nature. 1988 Jun 16;333(6174):686-8 [3374615] Science. 1988 Jul 15;241(4863):350-3 [2838908] Cell. 1988 Jul 15;54(2):199-207 [3390864] Gene. 1988 Jul 30;67(2):271-7 [3169576] Cell. 1988 Dec 2;55(5):899-906 [3191531] Genes Dev. 1988 Sep;2(9):1144-54 [3192076] Cell. 1988 Dec 23;55(6):1109-14 [3144438] Mol Endocrinol. 1989 Apr;3(4):734-43 [2725534] Cancer Res. 1989 Aug 15;49(16):4390-5 [2743328] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Forecasting requirements for physical therapists. AN - 85267752; pmid-7809197 AB - In response to the existing undersupply of physical therapists and the projected changes of the health care reform era, it is prudent for the profession to consider implementing a training strategy that would bring the supply of physical therapists in line with requirements. Before such a training strategy could be developed, however, the physical therapy community would need to produce a requirements forecast. This article compares the uses and limitations of the two major methods for generating health professions requirements--the "need-based" and "demand-based" approaches--and recommends a pragmatic, tailored approach to determining physical therapist requirements that uses easily obtainable data on staffing patterns of managed care plans. The proposed method draws from both need-based and demand-based models to produce complementary data on which to base policy formation. JF - Physical Therapy AU - Jacoby, I AD - Department of Preventive Medicine/Biometry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. PY - 1995 SP - 38 EP - 44-discussion 45 VL - 75 IS - 1 SN - 0031-9023, 0031-9023 KW - Physical Therapy Techniques KW - United States KW - Health Services Needs and Demand KW - Human KW - Forecasting KW - Models, Statistical KW - Models, Economic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85267752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+Therapy&rft.atitle=Forecasting+requirements+for+physical+therapists.&rft.au=Jacoby%2C+I&rft.aulast=Jacoby&rft.aufirst=I&rft.date=1995-01-01&rft.volume=75&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Physical+Therapy&rft.issn=00319023&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effects of halogenated and non-halogenated anesthetics on diaspirin cross-linked hemoglobin induced contractions of porcine pulmonary veins. AN - 77663296; 7581834 AB - Diaspirin crosslinked hemoglobin (DCLHb) is a resuscitative fluid presently undergoing clinical trials. Administration of DCLHb is associated with an elevation of mean arterial pressure in vivo and contraction of isolated blood vessels in vitro. The mechanisms for the vascular actions are unknown but may be due to inhibition of nitric oxide (NO). Halothane has been reported to inhibit NO induced relaxation. We examined the effect of anesthetics on DCLHb induced contraction of blood vessels. Porcine pulmonary veins were excised, cut into rings and placed in organ chambers filled with 25 ml Krebs-Ringer solution (37 degrees C). Following equilibration at their optimal length the rings were exposed to increasing concentrations of serotonin(10(-8)M-10(-5)M). Endothelial activity was confirmed by relaxation greater than 80% with ACh (10(-6)M). DCLHb (1.5 x 10(-8)M to 6 x 10(-7)M) contracted porcine pulmonary veins (1.04 +/- 0.17g to 3.45 +/- 0.22g), and halothane (0.5% and 1%) significantly inhibited these DCLHb induced contractions in a dose-related manner (-41.6 +/- 8.1% and -73.3 +/- 8.2%, respectively). At equi-molar concentrations, isoflurane had no inhibitory activity. The relative effect of these volatile anesthetics is consistent with their inhibitory actions on other heme containing proteins. Propofol (10(-5)M) only has inhibitory effects on lower concentrations of DCLHb. Fentanyl did not have inhibitory effects. These results suggest that halogenated anesthetics may interact with the heme iron of DCLHb and inhibit its binding with NO. JF - Artificial cells, blood substitutes, and immobilization biotechnology AU - Jing, M AU - Ledvina, M A AU - Bina, S AU - Hart, J L AU - Muldoon, S M AD - Dept. of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. Y1 - 1995 PY - 1995 DA - 1995 SP - 487 EP - 494 VL - 23 IS - 4 SN - 1073-1199, 1073-1199 KW - Anesthetics, Inhalation KW - 0 KW - Anesthetics, Intravenous KW - Cross-Linking Reagents KW - Hemoglobins KW - Vasoconstrictor Agents KW - succinyldisalicylic acid KW - 578-19-8 KW - Isoflurane KW - CYS9AKD70P KW - Aspirin KW - R16CO5Y76E KW - Fentanyl KW - UF599785JZ KW - Halothane KW - UQT9G45D1P KW - Propofol KW - YI7VU623SF KW - Index Medicus KW - Swine KW - Animals KW - Drug Interactions KW - Aspirin -- analogs & derivatives KW - Male KW - Female KW - Pulmonary Veins -- drug effects KW - Hemoglobins -- pharmacology KW - Vasoconstrictor Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77663296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+cells%2C+blood+substitutes%2C+and+immobilization+biotechnology&rft.atitle=Effects+of+halogenated+and+non-halogenated+anesthetics+on+diaspirin+cross-linked+hemoglobin+induced+contractions+of+porcine+pulmonary+veins.&rft.au=Jing%2C+M%3BLedvina%2C+M+A%3BBina%2C+S%3BHart%2C+J+L%3BMuldoon%2C+S+M&rft.aulast=Jing&rft.aufirst=M&rft.date=1995-01-01&rft.volume=23&rft.issue=4&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Artificial+cells%2C+blood+substitutes%2C+and+immobilization+biotechnology&rft.issn=10731199&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-12-01 N1 - Date created - 1995-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dissection of LPS-induced signaling pathways in murine macrophages using LPS analogs, LPS mimetics, and agents unrelated to LPS. AN - 77574206; 8524949 AB - The model in Figure 3 summarizes the data presented above. Using the induction of the select panel of LPS-inducible genes and the phosphorylation on tyrosine of specific MAP kinases, we have been able to dissociate three signaling pathways shared by LPS and its analogs and mimetics: a pathway that leads to tyrosine phosphorylation, one that leads to the induction of a gene subset including TNF alpha, TNFR-2, and IL-1 beta, and a pathway that results in induction of IP-10, D3, and D8 gene expression. It is still unclear if macrophage activation by non-LPS products occurs entirely through distinct yet redundant pathways or if other signaling receptors ultimately tie into the same intermediate pathways. This approach may identify particular stimuli as tools to induce specific pathways leading to select gene subsets and/or tyrosine kinase activation and, perhaps, identify a pathway deficient in C3H/HeJ macrophages. JF - Progress in clinical and biological research AU - Vogel, S N AU - Manthey, C L AU - Perera, P Y AU - Li, Z Y AU - Henricson, B E AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Y1 - 1995 PY - 1995 DA - 1995 SP - 421 EP - 431 VL - 392 SN - 0361-7742, 0361-7742 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD14 KW - Lipid A KW - Lipopolysaccharides KW - Phosphoproteins KW - Xanthenes KW - Xanthones KW - diphosphoryl lipid A KW - vadimezan KW - 0829J8133H KW - SDZ 880-431 KW - 101662-30-0 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Animals KW - Xanthenes -- pharmacology KW - In Vitro Techniques KW - Mice, Inbred C3H KW - Paclitaxel -- pharmacology KW - Mice KW - Gene Expression Regulation -- drug effects KW - Antigens, CD14 -- immunology KW - Antibodies, Monoclonal -- pharmacology KW - Lipid A -- pharmacology KW - Lipid A -- analogs & derivatives KW - Phosphoproteins -- metabolism KW - Signal Transduction -- physiology KW - Lipopolysaccharides -- antagonists & inhibitors KW - Signal Transduction -- drug effects KW - Macrophages -- physiology KW - Lipopolysaccharides -- toxicity KW - Lipopolysaccharides -- chemistry KW - Macrophages -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77574206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Dissection+of+LPS-induced+signaling+pathways+in+murine+macrophages+using+LPS+analogs%2C+LPS+mimetics%2C+and+agents+unrelated+to+LPS.&rft.au=Vogel%2C+S+N%3BManthey%2C+C+L%3BPerera%2C+P+Y%3BLi%2C+Z+Y%3BHenricson%2C+B+E&rft.aulast=Vogel&rft.aufirst=S&rft.date=1995-01-01&rft.volume=392&rft.issue=&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-01-25 N1 - Date created - 1996-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Avirulence of rough mutants of Shigella flexneri: requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane. AN - 77124716; 7528731 AB - Mutations in the lipopolysaccharide (LPS) of Shigella spp. result in attenuation of the bacteria in both in vitro and in vivo models of virulence, although the precise block in pathogenesis is not known. We isolated defined mutations in two genes, galU and rfe, which directly affect synthesis of the LPS of S. flexneri 2a, in order to determine more precisely the step in virulence at which LPS mutants are blocked. The galU and rfe mutants invaded HeLa cells but failed to generate the membrane protrusions (fireworks) characteristic of intracellular motility displayed by wild-type shigellae. Furthermore, the galU mutant was unable to form plaques on a confluent monolayer of eucaryotic cells and the rfe mutant generated only tiny plaques. These observations indicated that the mutants were blocked in their ability to spread from cell to cell. Western immunoblot analysis of expression of IcsA, the protein essential for intracellular motility and intercellular spread, demonstrated that both mutants synthesized IcsA, although they secreted less of the protein to the extracellular medium than did the wild-type parent. More strikingly, the LPS mutants showed aberrant surface localization of IcsA. Unlike the unipolar localization of IcsA seen in the wild-type parent, the galU mutant expressed the protein in a circumferential fashion. The rfe mutant had an intermediate phenotype in that it displayed some localization of IcsA at one pole while also showing diffuse localization around the bacterium. Given the known structures of the LPS of wild-type S. flexneri 2a, the rfe mutant, and the galU mutant, we hypothesize that the core and O-antigen components of LPS are critical elements in the correct unipolar localization of IcsA. These observations indicate a more precise role for LPS in Shigella pathogenesis. JF - Infection and immunity AU - Sandlin, R C AU - Lampel, K A AU - Keasler, S P AU - Goldberg, M B AU - Stolzer, A L AU - Maurelli, A T AD - Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1995/01// PY - 1995 DA - January 1995 SP - 229 EP - 237 VL - 63 IS - 1 SN - 0019-9567, 0019-9567 KW - galU KW - rfe KW - Actins KW - 0 KW - Bacterial Proteins KW - DNA-Binding Proteins KW - Escherichia coli Proteins KW - Lipopolysaccharides KW - O Antigens KW - Polysaccharides, Bacterial KW - Transcription Factors KW - virG protein, Shigella flexneri KW - UTP-Glucose-1-Phosphate Uridylyltransferase KW - EC 2.7.7.9 KW - Transferases (Other Substituted Phosphate Groups) KW - EC 2.7.8.- KW - wecA protein, E coli KW - Index Medicus KW - HeLa Cells KW - Humans KW - Protein Processing, Post-Translational KW - UTP-Glucose-1-Phosphate Uridylyltransferase -- genetics KW - Actins -- metabolism KW - Lipopolysaccharides -- biosynthesis KW - Amino Acid Sequence KW - Models, Biological KW - Base Sequence KW - Transferases (Other Substituted Phosphate Groups) -- genetics KW - Virulence -- genetics KW - Carbohydrate Sequence KW - Molecular Sequence Data KW - Mutagenesis, Insertional KW - Cell Polarity -- physiology KW - Shigella flexneri -- pathogenicity KW - Transcription Factors -- metabolism KW - Shigella flexneri -- cytology KW - Shigella flexneri -- genetics KW - Polysaccharides, Bacterial -- metabolism KW - Cell Membrane -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77124716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Avirulence+of+rough+mutants+of+Shigella+flexneri%3A+requirement+of+O+antigen+for+correct+unipolar+localization+of+IcsA+in+the+bacterial+outer+membrane.&rft.au=Sandlin%2C+R+C%3BLampel%2C+K+A%3BKeasler%2C+S+P%3BGoldberg%2C+M+B%3BStolzer%2C+A+L%3BMaurelli%2C+A+T&rft.aulast=Sandlin&rft.aufirst=R&rft.date=1995-01-01&rft.volume=63&rft.issue=1&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-02 N1 - Date created - 1995-02-02 N1 - Date revised - 2017-01-13 N1 - Gene symbol - galU; rfe N1 - Genetic sequence - X66848; GENBANK; L32811 N1 - SuppNotes - Cited By: Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 [6546423] Infect Immun. 1984 Jan;43(1):391-6 [6360905] Infect Immun. 1985 Jul;49(1):164-71 [2989179] Cell. 1986 Aug 15;46(4):551-5 [3524856] J Bacteriol. 1991 Jan;173(2):926-8 [1702785] Mol Microbiol. 1991 Jan;5(1):187-95 [1849606] Mol Microbiol. 1991 Mar;5(3):695-713 [1710759] Rev Infect Dis. 1991 Mar-Apr;13 Suppl 4:S279-84 [1710816] Microbiol Rev. 1991 Jun;55(2):206-24 [1886518] J Bacteriol. 1991 Nov;173(21):7042-5 [1938907] J Bacteriol. 1992 Mar;174(5):1454-61 [1537791] Mol Microbiol. 1992 Jun;6(12):1605-16 [1495389] Mol Microbiol. 1992 Aug;6(15):2113-24 [1406252] Mol Microbiol. 1993 Jan;7(1):141-50 [8437516] J Bacteriol. 1993 Apr;175(8):2189-96 [8468279] J Bacteriol. 1993 Jul;175(13):3964-71 [8320212] Mol Microbiol. 1993 Jul;9(2):393-402 [7692219] J Bacteriol. 1993 Nov;175(22):7125-9 [8226658] J Bacteriol. 1994 Apr;176(8):2362-73 [8157605] J Bacteriol. 1994 May;176(9):2611-8 [8169209] J Bacteriol. 1994 May;176(10):2877-84 [7514591] J Med Microbiol. 1987 Jun;23(4):289-302 [2438412] Infect Immun. 1987 Nov;55(11):2681-8 [3312007] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2568-72 [3357883] J Bacteriol. 1989 Jan;171(1):353-9 [2644195] Proc Natl Acad Sci U S A. 1989 May;86(10):3867-71 [2542950] Infect Immun. 1989 Oct;57(10):2963-70 [2674014] Proc Natl Acad Sci U S A. 1990 Jan;87(2):743-7 [1689050] J Biol Chem. 1990 Mar 15;265(8):4646-51 [2155233] Infect Immun. 1990 Apr;58(4):1048-58 [2108086] J Biol Chem. 1990 Aug 15;265(23):13490-7 [2166030] J Bacteriol. 1966 Aug;92(2):518-20 [5330381] J Bacteriol. 1974 Feb;117(2):527-43 [4590475] J Bacteriol. 1977 Feb;129(2):908-15 [320195] Infect Immun. 1977 Jul;17(1):4-8 [328396] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Anal Biochem. 1981 Apr;112(2):195-203 [6266278] Infect Immun. 1982 Mar;35(3):852-60 [6279518] Anal Biochem. 1982 Jan 1;119(1):115-9 [6176137] Infect Immun. 1983 Feb;39(2):505-13 [6187681] J Bacteriol. 1983 Apr;154(1):269-77 [6187729] Infect Immun. 1983 Mar;39(3):1392-402 [6341237] Infect Immun. 1985 Apr;48(1):124-9 [3884506] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Yamba Marriage Systems: Spouses and Their Offspring between Protection and Affliction AN - 61418157; 9508021 AB - Analysis of marriage systems among the Yamba of Cameroon highlights the precarious positions of spouses & their offspring within the Yamba belief system, being a source of both blessing & curse from more powerful kin figures. Particularly, bride-wealth marriage establishes a protective relation from mother's father to daughter's son, while the bride-giver is more ambiguous: a source of protection, but a potential source of affliction if affinal obligations are not met by spouses. Some unorthodox marriage forms & customs are also detailed. 4 Figures, 29 References. Adapted from the source document. JF - ANTHROPOS AU - Gufler, Hermann AD - Catholic Mission Sabongari, PO Ndu NW Province Cameroon Y1 - 1995///0, PY - 1995 DA - 0, 1995 SP - 89 EP - 108 VL - 90 IS - 1-3 SN - 0257-9774, 0257-9774 KW - Yamba marriage system, spouse/offspring relations, Cameroon KW - Family Relations KW - Kinship KW - Traditional Societies KW - Cameroon KW - Marriage KW - Spouses KW - article KW - 0514: culture and social structure; social anthropology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61418157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ANTHROPOS&rft.atitle=Yamba+Marriage+Systems%3A+Spouses+and+Their+Offspring+between+Protection+and+Affliction&rft.au=Gufler%2C+Hermann&rft.aulast=Gufler&rft.aufirst=Hermann&rft.date=1995-01-01&rft.volume=90&rft.issue=1-3&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=ANTHROPOS&rft.issn=02579774&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ANTHB6 N1 - SubjectsTermNotLitGenreText - Marriage; Spouses; Cameroon; Traditional Societies; Kinship; Family Relations ER - TY - JOUR T1 - Land treatment of produced oily sand AN - 52713898; 1997-037398 JF - Bioremediation AU - Bleckmann, Charles A AU - Wilson, Ernest J AU - Hayes, Kelly W AU - Hercyk, Neta L A2 - Hinchee, Robert E. A2 - Kittel, Jeffrey A. A2 - Reisinger, H. James Y1 - 1995 PY - 1995 DA - 1995 SP - 293 EP - 299 PB - Battelle Press, Columbus, OH VL - 3, Vol. 6 KW - United States KW - soils KW - organic materials KW - biodegradation KW - degradation KW - asphalt KW - south-central Oklahoma KW - resins KW - pollutants KW - ammonium ion KW - soil treatment KW - pollution KW - rates KW - petroleum products KW - waste management KW - bitumens KW - organic compounds KW - Oklahoma KW - hydrocarbons KW - crude oil KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52713898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioremediation&rft.atitle=Land+treatment+of+produced+oily+sand&rft.au=Bleckmann%2C+Charles+A%3BWilson%2C+Ernest+J%3BHayes%2C+Kelly+W%3BHercyk%2C+Neta+L&rft.aulast=Bleckmann&rft.aufirst=Charles&rft.date=1995-01-01&rft.volume=3%2C+Vol.+6&rft.issue=&rft.spage=293&rft.isbn=1574770071&rft.btitle=&rft.title=Bioremediation&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Third international In situ and on-site bioreclamation symposia N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 9 N1 - PubXState - OH N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - #04467 N1 - SubjectsTermNotLitGenreText - ammonium ion; asphalt; biodegradation; bitumens; crude oil; degradation; hydrocarbons; Oklahoma; organic compounds; organic materials; petroleum products; pollutants; pollution; rates; resins; soil treatment; soils; south-central Oklahoma; United States; waste management ER - TY - JOUR T1 - Spiral bacteria in the human stomach: the gastric helicobacters. AN - 20665519; 9420654 AB - During the past decade, Helicobacter pylori has become recognized as one of the most common human pathogens, colonizing the gastric mucosa of almost all persons exposed to poor hygienic conditions from childhood. It also is often found, albeit with a lower frequency, in groups of high socioeconomic status. H. pylori causes chronic active gastritis and is a major factor in the pathogenesis of duodenal ulcers and, to a lesser extent, gastric ulcers. In addition, the presence of this bacterium is now recognized as a risk factor for gastric adenocarcinoma and lymphoma. Nevertheless, most infections appear without clinical consequences. In this second decade of intensive research, it is important to understand why H. pylori is sometimes a dangerous pathogen, and to determine how it can be eradicated in those at highest risk for severe disease. JF - Emerging Infectious Diseases AU - Dubois, A AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA., dubois@usuhsb.usuhs.mil Y1 - 1995 PY - 1995 DA - 1995 SP - 79 EP - 85 PB - U.S. National Center for Infectious Diseases, 1600 Clifton Rd VL - 1 IS - 3 SN - 1080-6040, 1080-6040 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Risk Abstracts KW - Helicobacter pylori KW - Gastric mucosa KW - Socioeconomics KW - Pathogens KW - Children KW - Socio-economic aspects KW - Ulcers KW - Risk factors KW - infection KW - Adenocarcinoma KW - Hygiene KW - lymphoma KW - Lymphoma KW - Gastritis KW - Stomach KW - A 01490:Miscellaneous KW - J 02400:Human Diseases KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20665519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Spiral+bacteria+in+the+human+stomach%3A+the+gastric+helicobacters.&rft.au=Dubois%2C+A&rft.aulast=Dubois&rft.aufirst=A&rft.date=1995-01-01&rft.volume=1&rft.issue=3&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Socio-economic aspects; Gastric mucosa; Ulcers; Risk factors; Pathogens; Hygiene; Children; Adenocarcinoma; Gastritis; Lymphoma; Stomach; infection; Socioeconomics; lymphoma; Helicobacter pylori ER - TY - JOUR T1 - Characterization and cloning of insecticidal peptides from the primitive weaving spider Diguetia canities AN - 17052552; 3882962 AB - Three potent insecticidal peptide toxins were purified from the venom of the primitive weaving spider, Diguetia canities. The toxins share significant homology (> 40%) in their amino acid sequences and are of related size (masses of 6371-7080 Da). In lepidopteran larvae, the toxins cause a progressive spastic paralysis, with 50% paralytic doses (PD sub(50)s) ranging from 0.38 to 3.18 nmol/g, suggesting them to be among the most potent insecticidal compounds yet described from arthropod venoms. The most potent of these toxins, DTX9.2, was cloned using a reverse transcription-polymerase chain reaction (RT-PCR). The cDNA encodes a 94 amino acid precursor which is processed to the active 56 amino acid peptide by removal of a signal and propeptide sequence. The gene encoding DTX9.2 was isolated and characterized. The transcriptional unit spans 5.5 kilobases and is segregated into five exons. DNA sequences upstream from the first exon contain a TATA box and two palindromic sequences (one with homology to a CAAT consensus) which together may constitute a functional promoter. The highly segmented gene structure observed for this small peptide suggests that a mechanism such as exon shuffling may have played a role in the evolution of this toxin family. JF - Insect Biochemistry and Molecular Biology AU - Krapcho, K J AU - Kral, RM Jr AU - Vanwagenen, B C AU - Eppler, K G AU - Morgan, T K AD - Dep. Mol. Biol., NPS Pharma.. Inc., 420 Chipeta Way, Salt Lake City, UT 84108, USA Y1 - 1995 PY - 1995 DA - 1995 SP - 991 EP - 1000 VL - 25 IS - 9 SN - 0965-1748, 0965-1748 KW - Diguetia canities KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts; Entomology Abstracts KW - insecticides KW - venom KW - Araneae KW - W2 32070:Animals KW - Z 05183:Toxicology & resistance KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17052552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Insect+Biochemistry+and+Molecular+Biology&rft.atitle=Characterization+and+cloning+of+insecticidal+peptides+from+the+primitive+weaving+spider+Diguetia+canities&rft.au=Krapcho%2C+K+J%3BKral%2C+RM+Jr%3BVanwagenen%2C+B+C%3BEppler%2C+K+G%3BMorgan%2C+T+K&rft.aulast=Krapcho&rft.aufirst=K&rft.date=1995-01-01&rft.volume=25&rft.issue=9&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=Insect+Biochemistry+and+Molecular+Biology&rft.issn=09651748&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - insecticides; venom; Araneae ER - TY - JOUR T1 - LPS-inducible responses in severe combined immunodeficiency (SCID) mice AN - 16999757; 3838869 AB - Lipopolysaccharide (LPS) is a potent bacterial product that has been shown to act on many different cell types both in vivo and in vitro. Injection of immunologically competent mice with LPS results in increased serum cytokine levels, followed by an array of pathophysiologic alterations that can ultimately lead to death. In this study, we examined the response of severe combined immunodeficient (SCID) mice to LPS. These mice lack mature T and B cells and have been shown to be an important model for analyzing the contribution of innate immune responses to infectious agents. Injection of SCID mice with LPS resulted in increases in CSF, TNF, and IFN levels in serum that were similar to the responses of immunocompetent controls. In response to LPS, both SCID and control mice exhibited similar levels of hypoglycemia. LPS-induced toxicity was assessed in D(+)-galactosamine-sensitized animals. SCID mice were comparably sensitive to the lethal effects of LPS as control BALB/c mice. To assess the role of natural killer (NK) cells in LPS-induced cytokine responses, BALB/c and SCID mice were injected with anti-asialo-GM1 antibody prior to injection of LPS. No significant effect on LPS-induced CSF or blood glucose levels were seen, although NK-depleted SCID mice produced somewhat more IFN in response to LPS than normal mice. Thus, NK cells are not a major source of these early LPS-induced cytokines. These data suggest that mature T and B cells and NK cells do not contribute to the initial wave of cytokines produced in response to LPS, but may contribute as secondary producers of cytokines involved in the cytokine cascade elicited by LPS injection. JF - Journal of Endotoxin Research AU - Falk, LA AU - McNally, R AU - Perera, P Y AU - Kenny, J AU - Vogel, S N AD - Dep. Microbiol. and Immun., USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA Y1 - 1995 PY - 1995 DA - 1995 SP - 273 EP - 280 VL - 2 IS - 4 SN - 0968-0519, 0968-0519 KW - lipopolysaccharides KW - mice KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - endotoxins KW - lymphocytes T KW - immunodeficiency KW - natural killer cells KW - lymphocytes B KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16999757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=LPS-inducible+responses+in+severe+combined+immunodeficiency+%28SCID%29+mice&rft.au=Falk%2C+LA%3BMcNally%2C+R%3BPerera%2C+P+Y%3BKenny%2C+J%3BVogel%2C+S+N&rft.aulast=Falk&rft.aufirst=LA&rft.date=1995-01-01&rft.volume=2&rft.issue=4&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - immunodeficiency; lymphocytes T; lymphocytes B; natural killer cells; endotoxins ER - TY - JOUR T1 - Lipopolysaccharide (LPS)-specific monoclonal antibodies regulate LPS uptake and LPS-induced tumor necrosis factor- alpha responses by human monocytes AN - 16994294; 3835713 AB - Lipopolysaccharide (LPS)-monocyte/macrophage interactions are central to the infected host's inflammatory response to gram-negative bacteria. Flow cytometry was used to analyze the regulation by LPS-specific monoclonal antibodies (MAbs) of fluorescein isothiocyanate-conjugated LPS uptake by human peripheral blood monocytes. The uptake of LPS was stimulated by fresh or heat-inactivated serum (NHS or Delta NHS) or by LPS-binding protein and inhibited by alpha -LPS or alpha -CD14 (LPS receptor) MAbs. The inhibition by alpha -LPS MAbs of CD14-mediated LPS uptake was offset in the presence of NHS by a simultaneous MAb-mediated increase in LPS uptake that was blocked by alpha -complement receptor 1. Monocyte tumor necrosis factor- alpha responses to LPS were augmented by NHS and Delta NHS and inhibited by alpha -LPS MAbs. Thus, alpha -LPS MAbs down-regulate the proinflammatory uptake of LPS by human monocytes via membrane-bound CD14 while promoting complement-mediated opsonic uptake through membrane-associated CR1. JF - Journal of Infectious Diseases AU - Pollack, M AU - Espinoza, A M AU - Guelde, G AU - Koles, N L AU - Wahl, L M AU - Ohl, CA AD - Dep. Med., USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA Y1 - 1995 PY - 1995 DA - 1995 SP - 794 EP - 804 VL - 172 IS - 3 SN - 0022-1899, 0022-1899 KW - lipopolysaccharides KW - tumor necrosis factor- alpha KW - CD14 antigen KW - Toxicology Abstracts KW - endotoxins KW - Salmonella minnesota KW - Escherichia coli KW - monocytes KW - monoclonal antibodies KW - man KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16994294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Lipopolysaccharide+%28LPS%29-specific+monoclonal+antibodies+regulate+LPS+uptake+and+LPS-induced+tumor+necrosis+factor-+alpha+responses+by+human+monocytes&rft.au=Pollack%2C+M%3BEspinoza%2C+A+M%3BGuelde%2C+G%3BKoles%2C+N+L%3BWahl%2C+L+M%3BOhl%2C+CA&rft.aulast=Pollack&rft.aufirst=M&rft.date=1995-01-01&rft.volume=172&rft.issue=3&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Salmonella minnesota; endotoxins; monoclonal antibodies; monocytes; man ER - TY - JOUR T1 - Functional properties of isotype-switched immunoglobulin M (IgM) and IgG monoclonal antibodies to Pseudomonas aeruginosa lipopolysaccharide AN - 16972269; 3821206 AB - Controversy exists regarding isotype-related differences in the antibacterial and protective properties of lipopolysaccharide (LPS)-specific antibodies of the immunoglobulin M (IgM) class and various IgG subclasses. To clarify this issue, a murine hybridoma secreting IgM monoclonal antibody (MAb) specific for the O polysaccharide of Pseudomonas aeruginosa serogroup O6 LPS was class switched, by sib selection, to produce an IgG3 MAb with identical specificity and variable region heavy and light chain nucleotide sequences. This IgG3-secreting cell line was further switched to the production of O-specific, variable region-identical IgG1, IgG2b, and IgG2a MAbs. Functional comparisons of these LPS-specific IgM and IgG MAb isotypes revealed similar LPS binding, opsonic, and protective activities. Relatively minor isotype-related differences in levels of efficiency of MAb-mediated, complement-dependent opsonophagocytic killing (IgM > IgG2a > IgG3 > IgG2b > IgG1) were not associated with corresponding differences in in vivo functions. These findings, in conjunction with previously published data, support a cautious approach to generic conclusions regarding the immunotherapeutic superiority of LPS-specific antibodies belonging to either the IgM or IgG class or to a particular IgG subclass. JF - Infection and Immunity AU - Pollack, M AU - Koles, N L AU - Preston, MJ AU - Brown, B J AU - Pier, G B AD - Dep. Med., USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA Y1 - 1995 PY - 1995 DA - 1995 SP - 4481 EP - 4488 VL - 63 IS - 11 SN - 0019-9567, 0019-9567 KW - lipopolysaccharides KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - immunoglobulin M KW - immunoglobulin G KW - Pseudomonas aeruginosa KW - monoclonal antibodies KW - F 06049:IgM KW - W3 33375:Antibodies KW - J 02833:Immune response and immune mechanisms KW - F 06008:Bacteria KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16972269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Functional+properties+of+isotype-switched+immunoglobulin+M+%28IgM%29+and+IgG+monoclonal+antibodies+to+Pseudomonas+aeruginosa+lipopolysaccharide&rft.au=Pollack%2C+M%3BKoles%2C+N+L%3BPreston%2C+MJ%3BBrown%2C+B+J%3BPier%2C+G+B&rft.aulast=Pollack&rft.aufirst=M&rft.date=1995-01-01&rft.volume=63&rft.issue=11&rft.spage=4481&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - immunoglobulin M; immunoglobulin G; monoclonal antibodies; Pseudomonas aeruginosa ER - TY - JOUR T1 - Aquatic toxicity variability for fresh- and saltwater species in refinery wastewater effluent AN - 13653145; 199504973 AB - Freshwater species were used for toxicity reduction or toxicity identification evaluations of refinery wastewater effluents according to U.S. EPA protocols which required marine species to be used. The alternatives were used to examine the situation where an estuary receiving refinery effluent contained a high proportion of freshwater. Four test species were exposed to effluent concentrations of 6.25-100 per cent (volume by volume), the endpoint being mortality. The effluents were also assessed by the Microtox test. Of the 2 freshwater and 2 saltwater species tested, the mysid shrimp Mysidopsis bahia was the most sensitive to unidentified toxicants but no strong correlations of this sensitivity to that of other organisms or to several wastewater constituents were identified. M. bahia and sheepshead minnow (Cyprinodon variegatus), the saltwater species specified by U.S. EPA, were more sensitive to toxicants than Ceriodaphnia dubia and fathead minnow (Pimephales promelas), the tested freshwater species. The Microtox test was also relatively insensitive. There was no advantage in using a freshwater species. JF - Environmental Toxicology and Chemistry AU - Bleckmann, CA AU - Rabe, B AU - Edgmon, S J AU - Fillingame, D AD - Air Force Institute of Technology, Ohio Y1 - 1995 PY - 1995 DA - 1995 SP - 1219 EP - 1223 VL - 14 IS - 7 SN - 0730-7268, 0730-7268 KW - U.s. environmental protection agency KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13653145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Aquatic+toxicity+variability+for+fresh-+and+saltwater+species+in+refinery+wastewater+effluent&rft.au=Bleckmann%2C+CA%3BRabe%2C+B%3BEdgmon%2C+S+J%3BFillingame%2C+D&rft.aulast=Bleckmann&rft.aufirst=CA&rft.date=1995-01-01&rft.volume=14&rft.issue=7&rft.spage=1219&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - The environment, remote sensing, and malaria control. AN - 77704999; 7840472 AB - Results of studies in California, Mexico and Belize demonstrate the value of remote sensing technology for studying vector-borne diseases. These studies have also shown that it is necessary to fully define the environmental factors associated with the presence of vectors and disease transmission, and to be able to detect these environmental factors with image data. These studies, and other published reports, are demonstrating many potential uses of remotely sensed data in managing and targeting vector and disease control measures. JF - Annals of the New York Academy of Sciences AU - Roberts, D R AU - Rodriguez, M H AD - Department of Preventive Medicine/Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1994/12/15/ PY - 1994 DA - 1994 Dec 15 SP - 396 EP - 402 VL - 740 SN - 0077-8923, 0077-8923 KW - Index Medicus KW - Space life sciences KW - Animals KW - Aedes KW - Humans KW - Insect Vectors KW - Malaria -- prevention & control KW - Spacecraft KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77704999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=The+environment%2C+remote+sensing%2C+and+malaria+control.&rft.au=Roberts%2C+D+R%3BRodriguez%2C+M+H&rft.aulast=Roberts&rft.aufirst=D&rft.date=1994-12-15&rft.volume=740&rft.issue=&rft.spage=396&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-24 N1 - Date created - 1995-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Should oral steroids be the primary treatment for allergic fungal sinusitis? AN - 85159266; pmid-7882886 AB - A case of Allergic Fungal Sinusitis successfully controlled with oral corticosteroids followed by endoscopic sinus surgery is presented. The clinical diagnosis of AFS is emphasized. Endoscopic sinus surgery is preferable to open sinus techniques since the underlying mucosal disease is reversible. A prospective study is needed to determine the most appropriate treatment for this unique clinical disorder. JF - Ear, Nose, and Throat Journal AU - Roth, M AD - USUHS, Bethesda, MD. PY - 1994 SP - 928 EP - 930 VL - 73 IS - 12 SN - 0145-5613, 0145-5613 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85159266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear%2C+Nose%2C+and+Throat+Journal&rft.atitle=Should+oral+steroids+be+the+primary+treatment+for+allergic+fungal+sinusitis%3F&rft.au=Roth%2C+M&rft.aulast=Roth&rft.aufirst=M&rft.date=1994-12-01&rft.volume=73&rft.issue=12&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Ear%2C+Nose%2C+and+Throat+Journal&rft.issn=01455613&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Interplasmidic recombination following irradiation of the radioresistant bacterium Deinococcus radiodurans. AN - 76902409; 8002574 AB - Deinococcus radiodurans R1 and other members of the eubacterial family Deinococcaceae are extremely resistant to ionizing radiation and many other agents that damage DNA. For example, after irradiation, D. radiodurans can repair > 100 DNA double-strand breaks per chromosome without lethality or mutagenesis, while most other organisms can survive no more than 2 or 3 double-strand breaks. The unusual resistance of D. radiodurans is recA dependent, but the repair pathway(s) is not understood. Recently, we described how a plasmid present in D. radiodurans (plasmid copy number, approximately 6 per cell; chromosome copy number, approximately 4 per cell) during high-dose irradiation undergoes extreme damage like the chromosome and is retained by the cell without selection and fully repaired with the same efficiency as the chromosome. In the current work, we have investigated the repair of two similar plasmids within the same cell. These two plasmids were designed to provide both restriction fragment polymorphisms and a drug selection indicator of recombination. This study presents a novel system of analysis of in vivo damage and recombinational repair, exploiting the unique ability of D. radiodurans to survive extraordinarily high levels of DNA damage. We report that homologous recombination among plasmids following irradiation is extensive. For example, 2% of Tcs plasmids become Tcr as a result of productive recombination within a 929-bp region of the plasmids after repair. Our results suggest that each plasmid may participate in as many as 6.7 recombinational events during repair, a value that extrapolates to > 700 events per chromosome undergoing repair simultaneously. These results indicate that the study of plasmid recombination within D. radiodurans may serve as an accurate model system for simultaneously occurring repair in the chromosome. JF - Journal of bacteriology AU - Daly, M J AU - Ling, O AU - Minton, K W AD - Department of Pathology, F. E. Hébert School of Medicine, Uniformed Services, University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 7506 EP - 7515 VL - 176 IS - 24 SN - 0021-9193, 0021-9193 KW - Index Medicus KW - DNA Repair KW - Polymorphism, Genetic KW - Restriction Mapping KW - Drug Resistance, Microbial -- genetics KW - Selection, Genetic KW - Plasmids -- genetics KW - Recombination, Genetic KW - Gram-Positive Cocci -- radiation effects KW - Gram-Positive Cocci -- genetics KW - Radiation, Ionizing KW - Radiation Tolerance -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76902409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Interplasmidic+recombination+following+irradiation+of+the+radioresistant+bacterium+Deinococcus+radiodurans.&rft.au=Daly%2C+M+J%3BLing%2C+O%3BMinton%2C+K+W&rft.aulast=Daly&rft.aufirst=M&rft.date=1994-12-01&rft.volume=176&rft.issue=24&rft.spage=7506&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-25 N1 - Date created - 1995-01-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 1975 Feb;121(2):422-8 [1112771] J Bacteriol. 1963 Aug;86:294-8 [14058955] J Bacteriol. 1978 Apr;134(1):71-5 [649572] J Mol Biol. 1983 Jul 5;167(3):539-60 [6308264] Gene. 1984 Feb;27(2):151-60 [6327464] Zentralbl Mikrobiol. 1985;140(3):247-54 [2412365] Urol Int. 1986;41(3):202-6 [3750583] Microbiol Rev. 1987 Jun;51(2):221-71 [2439888] J Bacteriol. 1988 May;170(5):2126-35 [2834326] J Bacteriol. 1989 Jun;171(6):3133-8 [2785985] Plasmid. 1989 Sep;22(2):132-42 [2695951] J Bacteriol. 1990 Jun;172(6):2955-61 [2160933] Radiat Res. 1990 Oct;124(1):57-61 [2236496] Gene. 1991 Feb 1;98(1):45-52 [1849496] Int J Radiat Biol. 1991 Oct;60(4):613-26 [1680142] J Bacteriol. 1991 Oct;173(19):6110-7 [1655698] Plasmid. 1992 Nov;28(3):258-61 [1461940] J Bacteriol. 1994 Jun;176(12):3508-17 [8206827] Proc Natl Acad Sci U S A. 1968 Sep;61(1):176-83 [5303325] J Gen Microbiol. 1971 Apr;66(1):29-35 [4934504] C R Seances Soc Biol Fil. 1973;167(10):1506-10 [4799987] Mol Microbiol. 1994 Jul;13(1):9-15 [7984097] Syst Appl Microbiol. 1989;11:128-34 [11542160] J Mol Biol. 1977 Oct 15;116(1):81-98 [338918] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Manufacturing's Contribution to Pakistan's Economic Expansion: Commodity- or Service-Led Growth? AN - 1761716700; 199502584 AB - The impact of increased manufacturing output on the economic expansion of Pakistan is examined. The relationship between large scale manufacturing & gross domestic product (GDP) varies over time, but overall for 1974-1992, the impact of manufacturing on GDP was very weak. Analysis of relationships between manufacturing & individual sectors reveals: (1) expanded agricultural production resulted in increased manufacturing profitability; (2) expansion in small-scale manufacturing had a negative impact on agriculture; (3) few positive links occurred between large-scale manufacturing & construction or mining, but in recent years a positive linkage appeared between small-scale manufacturing & construction; (4) increases in transport & communications produced only a weak stimulus to large-scale manufacturing; (5) manufacturing had a fairly weak positive impace on commerce; & (6) the primary strong linkages between manufacturing & the economy were found in the areas of public administration, defense, & government services. It is suggested that manufacturing is not a leading sector of Pakistan's economy. 2 Tables, 1 Figure, 20 References. D. Generoli JF - Development Policy Review AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 369 EP - 385 VL - 12 IS - 4 SN - 0950-6764, 0950-6764 KW - economic expansion, Pakistan, 1974-1992 KW - increased manufacturing output KW - Manufacturing Industries KW - Pakistan KW - Agricultural Production KW - Economic Development KW - article KW - 7210: social policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761716700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Development+Policy+Review&rft.atitle=Manufacturing%27s+Contribution+to+Pakistan%27s+Economic+Expansion%3A+Commodity-+or+Service-Led+Growth%3F&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1994-12-01&rft.volume=12&rft.issue=4&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Development+Policy+Review&rft.issn=09506764&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Manufacturing Industries; Pakistan; Economic Development; Agricultural Production ER - TY - JOUR T1 - Functional consequences of posttranslational isomerization of Ser46 in a calcium channel toxin. AN - 76852345; 7973665 AB - The venom of the funnel-web spider Agelenopsis aperta contains several peptides that paralyze prey by blocking voltage-sensitive calcium channels. Two peptides, omega-Aga-IVB (IVB) and omega-Aga-IVC (IVC), have identical amino acid sequences, yet have opposite absolute configurations at serine 46. These toxins had similar selectivities for blocking voltage-sensitive calcium channel subtypes but different potencies for blocking P-type voltage-sensitive calcium channels in rat cerebellar Purkinje cells as well as calcium-45 influx into rat brain synaptosomes. An enzyme purified from venom converts IVC to IVB by isomerizing serine 46, which is present in the carboxyl-terminal tail, from the L to the D configuration. Unlike the carboxyl terminus of IVC, that of IVB was resistant to the major venom protease. These results show enzymatic activities in A. aperta venom being used in an unprecedented strategy for coproduction of necessary neurotoxins that possess enhanced stability and potency. JF - Science (New York, N.Y.) AU - Heck, S D AU - Siok, C J AU - Krapcho, K J AU - Kelbaugh, P R AU - Thadeio, P F AU - Welch, M J AU - Williams, R D AU - Ganong, A H AU - Kelly, M E AU - Lanzetti, A J AD - NPS Pharmaceuticals Incorporated, Salt Lake City, Utah 84108. Y1 - 1994/11/11/ PY - 1994 DA - 1994 Nov 11 SP - 1065 EP - 1068 VL - 266 IS - 5187 SN - 0036-8075, 0036-8075 KW - Agatoxins KW - 0 KW - Calcium Channel Blockers KW - Calcium Channels KW - Spider Venoms KW - omega-agatoxin-Aa4b KW - Serine KW - 452VLY9402 KW - Isomerases KW - EC 5.- KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Calcium -- metabolism KW - Animals KW - Stereoisomerism KW - Isomerases -- metabolism KW - Base Sequence KW - Purkinje Cells -- metabolism KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Synaptosomes -- metabolism KW - Structure-Activity Relationship KW - Spider Venoms -- toxicity KW - Calcium Channels -- metabolism KW - Spider Venoms -- metabolism KW - Calcium Channel Blockers -- metabolism KW - Spider Venoms -- chemistry KW - Protein Processing, Post-Translational KW - Calcium Channel Blockers -- chemistry KW - Spider Venoms -- enzymology KW - Calcium Channel Blockers -- toxicity KW - Serine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76852345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Functional+consequences+of+posttranslational+isomerization+of+Ser46+in+a+calcium+channel+toxin.&rft.au=Heck%2C+S+D%3BSiok%2C+C+J%3BKrapcho%2C+K+J%3BKelbaugh%2C+P+R%3BThadeio%2C+P+F%3BWelch%2C+M+J%3BWilliams%2C+R+D%3BGanong%2C+A+H%3BKelly%2C+M+E%3BLanzetti%2C+A+J&rft.aulast=Heck&rft.aufirst=S&rft.date=1994-11-11&rft.volume=266&rft.issue=5187&rft.spage=1065&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-12-08 N1 - Date created - 1994-12-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Science. 1994 Nov 11;266(5187):996-7 [7973683] Erratum In: Science 1994 Dec 2;266(5190):1464 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Overview: biological processes relevant to drugs of dependence. AN - 77705097; 7841854 AB - Key points are highlighted from five papers that address biological processes underlying the actions of opiates, CNS stimulants, nicotine, alcohol, and benzodiazepines. It is noteworthy that: (1) positive and negative reinforcement are common processes underlying actions of drugs of dependence; (2) dopaminergic systems in the ventral tegmental area of the brain seem to be involved in the positive reinforcement of drugs of dependence; (3) GABA also may be involved in this positive reinforcement; (4) receptor sensitization and desensitization may be involved in the actions of drugs of dependence; (5) noradrenalin, 5-HT, ACh, NMDA and corticosteroids also may be involved in drug dependence; (6) motivational systems and processes in addition to positive and negative reinforcement deserve increased research attention; and (7) there may be genetic-based individual differences in drug dependence processes. JF - Addiction (Abingdon, England) AU - Grunberg, N E AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1994/11// PY - 1994 DA - November 1994 SP - 1443 EP - 1446 VL - 89 IS - 11 SN - 0965-2140, 0965-2140 KW - Neurotransmitter Agents KW - 0 KW - Psychotropic Drugs KW - Receptors, Neurotransmitter KW - Street Drugs KW - Index Medicus KW - Receptors, Neurotransmitter -- physiology KW - Animals KW - Neurotransmitter Agents -- physiology KW - Motivation KW - Humans KW - Receptors, Neurotransmitter -- drug effects KW - Substance-Related Disorders -- physiopathology KW - Brain -- physiopathology KW - Brain -- drug effects KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77705097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Overview%3A+biological+processes+relevant+to+drugs+of+dependence.&rft.au=Grunberg%2C+N+E&rft.aulast=Grunberg&rft.aufirst=N&rft.date=1994-11-01&rft.volume=89&rft.issue=11&rft.spage=1443&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-08 N1 - Date created - 1995-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effects of first- and second-order rate-limited sorption models on contaminant transport AN - 52810570; 1996-067040 JF - Eos, Transactions, American Geophysical Union AU - Coulliette, D L AU - Caspers, J L AU - Anonymous Y1 - 1994/11// PY - 1994 DA - November 1994 SP - 266 PB - American Geophysical Union, Washington, DC VL - 75 IS - 44, Suppl. SN - 0096-3941, 0096-3941 KW - solute transport KW - models KW - hydrology KW - finite element analysis KW - sorption KW - diffusion KW - transport KW - statistical analysis KW - pollution KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52810570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=The+effects+of+first-+and+second-order+rate-limited+sorption+models+on+contaminant+transport&rft.au=Coulliette%2C+D+L%3BCaspers%2C+J+L%3BAnonymous&rft.aulast=Coulliette&rft.aufirst=D&rft.date=1994-11-01&rft.volume=75&rft.issue=44%2C+Suppl.&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1994 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - diffusion; finite element analysis; hydrology; models; pollution; solute transport; sorption; statistical analysis; transport ER - TY - JOUR T1 - Acoustic Doppler measurements of sediment fluxes at Duck 94 AN - 52758032; 1997-014209 JF - Eos, Transactions, American Geophysical Union AU - Stanton, T P AU - Kanhanovich, K AU - Thornton, E B AU - Anonymous Y1 - 1994/11// PY - 1994 DA - November 1994 SP - 335 PB - American Geophysical Union, Washington, DC VL - 75 IS - 44, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - geophysical surveys KW - marine geology KW - nearshore sedimentation KW - Dare County North Carolina KW - turbulence KW - acoustical methods KW - Atlantic Coastal Plain KW - Northwest Atlantic KW - barrier islands KW - sediment transport KW - Doppler effect KW - sedimentation KW - geophysical methods KW - Duck North Carolina KW - case studies KW - Duck 94 field study KW - ocean waves KW - North Carolina KW - surveys KW - North Atlantic KW - backscattering KW - Atlantic Ocean KW - field studies KW - 20:Applied geophysics KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52758032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Acoustic+Doppler+measurements+of+sediment+fluxes+at+Duck+94&rft.au=Stanton%2C+T+P%3BKanhanovich%2C+K%3BThornton%2C+E+B%3BAnonymous&rft.aulast=Stanton&rft.aufirst=T&rft.date=1994-11-01&rft.volume=75&rft.issue=44%2C+Suppl.&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1994 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - acoustical methods; Atlantic Coastal Plain; Atlantic Ocean; backscattering; barrier islands; case studies; Dare County North Carolina; Doppler effect; Duck 94 field study; Duck North Carolina; field studies; geophysical methods; geophysical surveys; marine geology; nearshore sedimentation; North Atlantic; North Carolina; Northwest Atlantic; ocean waves; sediment transport; sedimentation; surveys; turbulence; United States ER - TY - JOUR T1 - Inhibition of LPS-mediated cell activation in vitro and in vivo by gangliosides. AN - 77083468; 7743601 AB - Addition of purified GM1 gangliosides inhibited lipopolysaccharide (LPS)-stimulated proliferation of purified B cells by greater than 90%. Addition of gangliosides to B cells as late as 120 min after the addition of LPS still inhibited B-cell proliferation, suggesting that inhibition did not simply reflect direct binding of LPS to gangliosides. Gangliosides also inhibited proliferation of B cells stimulated by anti-Ig antibodies, albeit to a lesser degree than inhibition of the LPS-stimulated response. The finding that B-cell proliferation stimulated by the combination of PMA+ionomycin was also inhibited by gangliosides suggests that its inhibitory activity did not reflect interference with binding of the B-cell stimuli to membrane receptors. The inhibitory effect of gangliosides was not restricted to B cells, since LPS-induced TNF production by macrophages was also inhibited in vitro. The inhibitory activity of gangliosides was also seen in vivo, and mice injected with soluble gangliosides or implanted with slow-release pellets impregnated with gangliosides showed reduced TNF production in vivo in response to LPS. Mice that were implanted with these slow-release pellets were also protected from LPS-induced lethality. Thus, while only 10% of control mice survived injection with LPS+galactosamine, the experimental group showed a 64% survival. It is likely that this protective effect reflects the ability of gangliosides to suppress LPS-mediated TNF production. This model provides a basis for studying a regulatory role for gangliosides in B-cell activation in vitro and macrophage activation in vitro and in vivo. Furthermore, it suggests new approaches to suppress the toxic effects induced by LPS in vivo. JF - Circulatory shock AU - Mond, J J AU - Witherspoon, K AU - Yu, R K AU - Perera, P Y AU - Vogel, S N AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 57 EP - 62 VL - 44 IS - 2 SN - 0092-6213, 0092-6213 KW - Gangliosides KW - 0 KW - Lipopolysaccharides KW - Sialic Acids KW - Tumor Necrosis Factor-alpha KW - N-Acetylneuraminic Acid KW - GZP2782OP0 KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Tumor Necrosis Factor-alpha -- drug effects KW - Lipopolysaccharides -- pharmacology KW - Sialic Acids -- pharmacology KW - Mice, Inbred C57BL KW - Cell Division -- drug effects KW - Mice KW - Tumor Necrosis Factor-alpha -- metabolism KW - Female KW - B-Lymphocytes -- drug effects KW - Gangliosides -- pharmacology KW - Macrophages -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77083468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulatory+shock&rft.atitle=Inhibition+of+LPS-mediated+cell+activation+in+vitro+and+in+vivo+by+gangliosides.&rft.au=Mond%2C+J+J%3BWitherspoon%2C+K%3BYu%2C+R+K%3BPerera%2C+P+Y%3BVogel%2C+S+N&rft.aulast=Mond&rft.aufirst=J&rft.date=1994-10-01&rft.volume=44&rft.issue=2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Circulatory+shock&rft.issn=00926213&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-06-13 N1 - Date created - 1995-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Voltage-activated potassium currents of rabbit osteoclasts: effects of extracellular calcium. AN - 76777410; 7524343 AB - The effects of increased extracellular Ca2+ concentration ([Ca2+]e) were examined on a delayed-rectifier K+ current (IK) and an inward-rectifier K+ current (IK1) in rabbit osteoclasts. Elevation of [Ca2+]e from 1.8 to 18 mM shifted the half point for IK activation by +11.5 mV and the voltage dependence of inactivation by +9.7 mV and slowed the rate of IK activation and deactivation. These effects of elevated [Ca2+]e on IK are consistent with screening of cell surface negative charge. However, elevation of [Ca2+]e increased the voltage-dependent kinetics of IK inactivation at all potentials tested, inconsistent with that predicted by simple surface charge theory. This finding suggests an additional, regulatory role for [Ca2+]e in the gating of IK channels. Some osteoclasts had an IK1, which was decreased when [Ca2+]e was raised from 1.8 to 18 mM. The physiological function of both types of K+ currents remains to be determined, and it is not clear whether these currents are involved with the coupling of cytosolic [Ca2+] to [Ca2+]e. JF - The American journal of physiology AU - Hammerland, L G AU - Parihar, A S AU - Nemeth, E F AU - Sanguinetti, M C AD - NPS Pharmaceuticals, Salt Lake City, Utah 84108. Y1 - 1994/10// PY - 1994 DA - October 1994 SP - C1103 EP - C1111 VL - 267 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Scorpion Venoms KW - 0 KW - Charybdotoxin KW - 115422-61-2 KW - Hydrogen KW - 7YNJ3PO35Z KW - Magnesium KW - I38ZP9992A KW - Potassium KW - RWP5GA015D KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Osmolar Concentration KW - Hydrogen -- pharmacology KW - Animals KW - Scorpion Venoms -- pharmacology KW - Electric Conductivity KW - Magnesium -- pharmacology KW - Rabbits KW - Osteoclasts -- physiology KW - Calcium -- metabolism KW - Potassium -- physiology KW - Extracellular Space -- metabolism KW - Potassium -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76777410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Voltage-activated+potassium+currents+of+rabbit+osteoclasts%3A+effects+of+extracellular+calcium.&rft.au=Hammerland%2C+L+G%3BParihar%2C+A+S%3BNemeth%2C+E+F%3BSanguinetti%2C+M+C&rft.aulast=Hammerland&rft.aufirst=L&rft.date=1994-10-01&rft.volume=267&rft.issue=4+Pt+1&rft.spage=C1103&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-11-22 N1 - Date created - 1994-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prospective randomized comparison of high-dose and standard-dose etoposide and cisplatin chemotherapy in patients with extensive-stage small-cell lung cancer. AN - 76760818; 7931470 AB - We performed a prospective randomized clinical trial to determine whether higher doses of etoposide and cisplatin (EP) yield more complete responses or longer survival in small-cell lung cancer (SCLC) patients. Ninety patients with previously untreated extensive-stage SCLC fulfilled criteria for randomization to standard-dose versus high-dose EP. Another 25 patients at risk of excessive toxicity from high-dose treatment were given standard-dose therapy. During cycles 1 and 2 of EP, patients on standard-dose treatment received intravenous etoposide 80 mg/m2 on days 1 to 3 and cisplatin 80 mg/m2 on day 1 every 3 weeks; high-dose treatment consisted of etoposide 80 mg/m2 on days 1 to 5 and cisplatin 27 mg/m2 on days 1 to 5 every 3 weeks. All patients received standard-dose EP in cycles 3 and 4. In cycles 5 through 8, completely responding patients continued standard-dose EP; all other patients received either cyclophosphamide, doxorubicin, and vincristine, or (if possible) a combination drug program based on in vitro drug sensitivity testing of tumor-cell lines established from individual patients. Despite 68% higher doses and a 46% higher dose-rate intensity actually given to patients randomized to receive high-dose relative to those randomized to receive standard-dose EP, complete response rates (23% v 22%; P = .99) and median survival durations (10.7 and 11.4 months, respectively; P = .68) were virtually identical. Complete responses occurred in 4% of patients and the median survival duration was 5.8 months in nonrandomized patients. Leukopenia (P < .0001), thrombocytopenia (P < .0001), febrile neutropenia (P = .01), and weight loss (P = .02) were significantly more common in patients randomized to receive high-dose compared with standard-dose EP. No therapeutic benefits resulted from increasing planned doses by 67% for the first two cycles of EP in patients with extensive-stage SCLC. Higher doses were associated with substantially worse toxicities. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Ihde, D C AU - Mulshine, J L AU - Kramer, B S AU - Steinberg, S M AU - Linnoila, R I AU - Gazdar, A F AU - Edison, M AU - Phelps, R M AU - Lesar, M AU - Phares, J C AD - National Cancer Institute-Navy Medical Oncology Branch, Uniformed Services University of the Health Sciences, Bethesda, MD. Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 2022 EP - 2034 VL - 12 IS - 10 SN - 0732-183X, 0732-183X KW - Etoposide KW - 6PLQ3CP4P3 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Drug Administration Schedule KW - Neoplasm Staging KW - Humans KW - Aged KW - Cisplatin -- administration & dosage KW - Prospective Studies KW - Survival Rate KW - Etoposide -- administration & dosage KW - Leukopenia -- chemically induced KW - Adult KW - Weight Loss -- drug effects KW - Thrombocytopenia -- chemically induced KW - Etoposide -- adverse effects KW - Middle Aged KW - Cisplatin -- adverse effects KW - Female KW - Male KW - Remission Induction KW - Proportional Hazards Models KW - Carcinoma, Small Cell -- pathology KW - Carcinoma, Small Cell -- mortality KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Small Cell -- drug therapy KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76760818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Prospective+randomized+comparison+of+high-dose+and+standard-dose+etoposide+and+cisplatin+chemotherapy+in+patients+with+extensive-stage+small-cell+lung+cancer.&rft.au=Ihde%2C+D+C%3BMulshine%2C+J+L%3BKramer%2C+B+S%3BSteinberg%2C+S+M%3BLinnoila%2C+R+I%3BGazdar%2C+A+F%3BEdison%2C+M%3BPhelps%2C+R+M%3BLesar%2C+M%3BPhares%2C+J+C&rft.aulast=Ihde&rft.aufirst=D&rft.date=1994-10-01&rft.volume=12&rft.issue=10&rft.spage=2022&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-11-04 N1 - Date created - 1994-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Construction of a BALB/c congenic mouse, C.C3H-Lpsd, that expresses the Lpsd allele: analysis of chromosome 4 markers surrounding the Lps gene. AN - 76741363; 7927709 AB - Development of a congenic BALB/c mouse strain that contains a segment of chromosome 4 including the Lpsd allele of the lipopolysaccharide (LPS)-hyporesponsive C3H/HeJ strain is presented. On the basis of LPS-induced spleen cell mitogenesis, macrophage tumor necrosis factor secretion, and tyrosine phosphorylation in vitro and lethality in galactosamine-sensitized mice in vivo, the C.C3H-Lpsd strain provides a model of LPS hyporesponsiveness that is comparable to that of the parental C3H/HeJ strain. Analysis of markers in this region indicates that length of the donor fragment is approximately 5.5 centimorgans. Thus, the C.C3H-Lpsd strain provides an important genetic tool for analysis of markers in this region and for examining functional effects of Lpsd expression on the BALB/c background. JF - Infection and immunity AU - Vogel, S N AU - Wax, J S AU - Perera, P Y AU - Padlan, C AU - Potter, M AU - Mock, B A AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 4454 EP - 4459 VL - 62 IS - 10 SN - 0019-9567, 0019-9567 KW - Lps KW - Genetic Markers KW - 0 KW - Lipopolysaccharides KW - Index Medicus KW - Animals KW - Mice KW - Mice, Inbred BALB C KW - Male KW - Female KW - Chromosomes KW - Alleles KW - Mice, Inbred C3H -- genetics KW - Lipopolysaccharides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76741363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Construction+of+a+BALB%2Fc+congenic+mouse%2C+C.C3H-Lpsd%2C+that+expresses+the+Lpsd+allele%3A+analysis+of+chromosome+4+markers+surrounding+the+Lps+gene.&rft.au=Vogel%2C+S+N%3BWax%2C+J+S%3BPerera%2C+P+Y%3BPadlan%2C+C%3BPotter%2C+M%3BMock%2C+B+A&rft.aulast=Vogel&rft.aufirst=S&rft.date=1994-10-01&rft.volume=62&rft.issue=10&rft.spage=4454&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-11-04 N1 - Date created - 1994-11-04 N1 - Date revised - 2017-01-13 N1 - Gene symbol - Lps N1 - SuppNotes - Cited By: Genet Res. 1967 Oct;10(2):195-8 [6064106] Mamm Genome. 1993;4 Spec No:S58-71 [8268685] J Embryol Exp Morphol. 1969 Apr;21(2):285-94 [4309830] Genet Res. 1969 Dec;14(3):329-31 [5367378] J Immunol. 1977 Jun;118(6):2088-93 [325138] J Immunol. 1978 Feb;120(2):422-4 [202651] J Immunol. 1978 Jan;120(1):249-53 [342603] J Exp Med. 1978 Jan 1;147(1):39-49 [342667] J Immunol. 1978 Nov;121(5):1664-70 [101590] J Immunol. 1979 Feb;122(2):619-22 [368244] Proc Natl Acad Sci U S A. 1979 Nov;76(11):5939-43 [293694] Nucleic Acids Res. 1984 Aug 10;12(15):6073-90 [6548015] J Hered. 1987 May-Jun;78(3):143-6 [3475376] J Immunol. 1988 Dec 15;141(12):4196-202 [3143760] J Immunol. 1989 Nov 1;143(9):3001-6 [2572648] J Biol Chem. 1990 Jun 25;265(18):10201-9 [2354997] Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):869-73 [1704135] J Immunol. 1991 Nov 15;147(10):3632-7 [1682379] J Biol Chem. 1992 Jul 25;267(21):14955-62 [1321821] Genetics. 1992 Jun;131(2):423-47 [1353738] Carcinogenesis. 1992 Oct;13(10):1681-97 [1423827] Mamm Genome. 1992;3(11):653-5 [1360280] Genomics. 1993 Apr;16(1):113-22 [8098006] Cell. 1993 Jul 2;73(7):1349-60 [8391931] J Exp Med. 1993 Aug 1;178(2):695-702 [8101863] Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9499-503 [8105477] Science. 1993 Oct 1;262(5130):57-66 [8211130] Biochemistry. 1967 Aug;6(8):2363-72 [4867999] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - District Elections and the Power of Municipal Employee Unions AN - 61379848; 9502739 AB - Explores the effects of the institutional structure of local government on public sector labor markets. Here, the differential effects of the two main systems used to elect city council members -- district vs citywide elections -- are examined. It is hypothesized that in district-election cities, municipal employees, especially those who are unionized, face a lower cost of influencing city council candidates &, consequently, will have greater power to influence employment conditions. Empirical data (1982) on US cities with 25,000+ population (N = 561) are used to estimate both reduced form & structural wage & employment equations. The results are consistent with the basic hypothesis: district elections provide a more fertile ground for municipal employees, especially those organized in unions, to affect their employment conditions. 5 Tables, 26 References. Adapted from the source document. JF - Journal of Labor Research AU - Mehay, Stephen L AU - Gonzalez, Rodolfo A AD - US Naval Postgraduate School, Monterey CA 93943 Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 387 EP - 402 VL - 15 IS - 4 SN - 0195-3613, 0195-3613 KW - public sector labor markets KW - local government structure KW - 1982 empirical data KW - US cities KW - Public Sector KW - Elections KW - Unions KW - Civil Service KW - Labor Market KW - Local Government KW - article KW - 0621: complex organization; jobs, work organization, workplaces, & unions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61379848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Labor+Research&rft.atitle=District+Elections+and+the+Power+of+Municipal+Employee+Unions&rft.au=Mehay%2C+Stephen+L%3BGonzalez%2C+Rodolfo+A&rft.aulast=Mehay&rft.aufirst=Stephen&rft.date=1994-10-01&rft.volume=15&rft.issue=4&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Journal+of+Labor+Research&rft.issn=01953613&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JLRED6 N1 - SubjectsTermNotLitGenreText - Public Sector; Labor Market; Local Government; Civil Service; Elections; Unions ER - TY - JOUR T1 - The Dilemma of Planning in Large-Scale Public Organizations: The Case of the United States Navy AN - 61375497; 9505479 AB - Although planning enables organizations to coordinate their activities, if the requirements of the planning cycle exceed an organization's ability to respond in a timely fashion to its external environment, then the organization is forced to use alternative planning approaches. Alternatives developed in business are outlined, & it is illustrated how similar approaches have been used in the US Navy. Recommendations are offered for planning in other large-scale public organizations that need to compensate for size as they engage in organizational planning. 1 Exhibit, 86 References. Adapted from the source document. JF - Journal of Public Administration Research and Theory AU - Roberts, Nancy C AU - Wargo, Linda AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 469 EP - 491 VL - 4 IS - 4 SN - 1053-1858, 1053-1858 KW - planning, large-scale public organizations KW - illustrative example KW - US Navy KW - Public Sector KW - Planning KW - Armed Forces KW - Public Administration KW - Organizational Development KW - Interorganizational Relations KW - article KW - 0624: complex organization; bureaucratic structure/organizational sociology KW - 2454: policy, planning, forecasting; planning & forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61375497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Administration+Research+and+Theory&rft.atitle=The+Dilemma+of+Planning+in+Large-Scale+Public+Organizations%3A+The+Case+of+the+United+States+Navy&rft.au=Roberts%2C+Nancy+C%3BWargo%2C+Linda&rft.aulast=Roberts&rft.aufirst=Nancy&rft.date=1994-10-01&rft.volume=4&rft.issue=4&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Administration+Research+and+Theory&rft.issn=10531858&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JPRTEC N1 - SubjectsTermNotLitGenreText - Interorganizational Relations; Organizational Development; Public Administration; Planning; Public Sector; Armed Forces ER - TY - JOUR T1 - An analytical solution to equations describing rate-limited soil vapor extraction of contaminants in the vadose zone AN - 50168824; 1997-069135 AB - Soil vapor extraction (SVE) is a technique that is commonly used to remove volatile organic compounds from the vadose zone. Recent research has demonstrated that rate-limited sorption and desorption of these compounds can have a profound impact on the concentration reductions achievable by SVE. In this note, one-dimensional equations presented by Brusseau (1991), which describe rate-limited transport of sorbing organic compounds in the vadose zone, are modified to model a SVE remediation at an idealized site and analytically solved. The analytical model presented herein describes transport of a sorbing organic contaminant in a converging radial flow field in the vadose zone, with sorption rate limitations described by first-order rate expressions. The model equations are solved in the Laplace domain and numerically inverted to simulate contaminant concentrations at an extraction well. A Laplace domain solution for the total contaminant mass remaining in the vadose zone is also derived. It is shown that under certain conditions, rate-limited sorption can have a significant impact upon SVE remediation in the vadose zone. The solutions presented in this note may be useful in verifying numerical codes which are being developed to model organic transport in the vadose zone under conditions of rate-limited sorption. Copyright 1994 by the American Geophysical Union. JF - Water Resources Research AU - Goltz, Mark N AU - Oxley, Mark E Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 2691 EP - 2698 PB - American Geophysical Union, Washington, DC VL - 30 IS - 10 SN - 0043-1397, 0043-1397 KW - sorption KW - desorption KW - numerical models KW - pollutants KW - one-dimensional models KW - soil vapor extraction KW - unsaturated zone KW - pollution KW - techniques KW - remediation KW - volatiles KW - organic compounds KW - transport KW - volatile organic compounds KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50168824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Research&rft.atitle=An+analytical+solution+to+equations+describing+rate-limited+soil+vapor+extraction+of+contaminants+in+the+vadose+zone&rft.au=Goltz%2C+Mark+N%3BOxley%2C+Mark+E&rft.aulast=Goltz&rft.aufirst=Mark&rft.date=1994-10-01&rft.volume=30&rft.issue=10&rft.spage=2691&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Research&rft.issn=00431397&rft_id=info:doi/10.1029%2F94WR01775 L2 - http://www.agu.org/journals/wr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 25 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - WRERAQ N1 - SubjectsTermNotLitGenreText - desorption; numerical models; one-dimensional models; organic compounds; pollutants; pollution; remediation; soil vapor extraction; sorption; techniques; transport; unsaturated zone; volatile organic compounds; volatiles DO - http://dx.doi.org/10.1029/94WR01775 ER - TY - JOUR T1 - Defective transformation of chromosomal markers in DNA polymerase I mutants of the radioresistant bacterium Deinococcus radiodurans. AN - 76678043; 7520974 AB - The transformation efficiency of six independently selected chromosomal markers (four for rifampicin resistance and two for acriflavine resistance) was found to be reduced by about 3 logs in a Deinococcus radiodurans strain that was isogenic with wild type except for an insertional mutation in the pol gene that eliminated DNA polymerase I activity (strain 6R1A). D. radiodurans strains UV17 and 303, previously obtained by chemical mutagenesis, were determined to be partially deficient in DNA Pol I activity as assessed in a permeabilized cell system. Both UV17 and 303 demonstrated intermediate transforming efficiencies that correlated with their levels of residual polymerase activity. The transformation efficiency of strain 6R1A could be greatly restored by expression of cloned E. coli DNA Pol I, but not to wild-type levels. Plasmid transfer and chromosomal duplication insertion were not substantially affected by lack of DNA Pol I activity. D. radiodurans is known to possess extraordinarily efficient repair pathways for DNA damage, and is refractory to DNA damage-induced mutagenesis caused by numerous agents, including several that cause base mispairing. We suggest that D. radiodurans may differ from other naturally transformable bacteria in that DNA Pol I is needed to efficiently convert most drug-resistance markers. This unusual mechanism may be required to accomplish chromosomal conversion prior to correction of donor DNA by this organism's efficient repair pathways. JF - Mutation research AU - Fuchs, P AU - Agostini, H AU - Minton, K W AD - Department of Pathology, F.E. Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1994/09/01/ PY - 1994 DA - 1994 Sep 01 SP - 175 EP - 184 VL - 309 IS - 2 SN - 0027-5107, 0027-5107 KW - pol KW - polA KW - Genetic Markers KW - 0 KW - Acriflavine KW - 1T3A50395T KW - Kanamycin KW - 59-01-8 KW - Chloramphenicol KW - 66974FR9Q1 KW - DNA Polymerase I KW - EC 2.7.7.- KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Genotype KW - Gamma Rays KW - Models, Genetic KW - Plasmids KW - Mutation KW - Mutagenesis, Insertional KW - Ultraviolet Rays KW - Transformation, Bacterial KW - Genes, Bacterial KW - Gram-Positive Cocci -- enzymology KW - DNA Damage KW - DNA Polymerase I -- genetics KW - Gram-Positive Cocci -- radiation effects KW - Gram-Positive Cocci -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76678043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Defective+transformation+of+chromosomal+markers+in+DNA+polymerase+I+mutants+of+the+radioresistant+bacterium+Deinococcus+radiodurans.&rft.au=Fuchs%2C+P%3BAgostini%2C+H%3BMinton%2C+K+W&rft.aulast=Fuchs&rft.aufirst=P&rft.date=1994-09-01&rft.volume=309&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-09-29 N1 - Date created - 1994-09-29 N1 - Date revised - 2017-01-13 N1 - Gene symbol - pol; polA N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DNA repair in the extremely radioresistant bacterium Deinococcus radiodurans. AN - 76863638; 7984097 AB - Deinococcus radiodurans and other members of the same genus share extraordinary resistance to the lethal and mutagenic effects of ionizing and u.v. radiation and to many other agents that damage DNA. While it is known that this resistance is due to exceedingly efficient DNA repair, the molecular mechanisms responsible remain poorly understood. Following very high exposures to u.v. irradiation (e.g. 500 J m-2, which is non-lethal to D. radiodurans), this organism carries out extremely efficient excision repair accomplished by two separate nucleotide excision repair pathways acting simultaneously. One pathway requires the uvrA gene and appears similar to the UvrABC excinuclease pathway defined in Escherichia coli. The other excision repair pathway is specific for u.v. dimeric photoproducts, but is not mediated by a pyrimidine dimer DNA glycosylase. Instead, it is initiated by a second bona fide endonuclease that may recognize both pyrimidine dimers and pyrimidine-(6-4)pyrimidones. After high doses of ionizing-radiation (e.g. 1.5 Mrad), D. radiodurans can mend > 100 double-strand breaks (dsb) per chromosome without lethality or mutagenesis. Both dsb mending and survival are recA-dependent, indicating that efficient dsb mending proceeds via homologous recombination. D. radiodurans contains multiple chromosomes per cell, and it is proposed that dsb mending requires extensive recombination amongst these chromosomes, a novel phenomenon in bacteria. Thus, D. radiodurans may serve as an easily accessible model system for the double-strand-break-initiated interchromosomal recombination that occurs in eukaryotic cells during mitosis and meiosis. JF - Molecular microbiology AU - Minton, K W AD - Department of Pathology, F. E. Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1994/07// PY - 1994 DA - July 1994 SP - 9 EP - 15 VL - 13 IS - 1 SN - 0950-382X, 0950-382X KW - mtcA KW - mtcB KW - pol KW - recA KW - uvrA KW - uvsC KW - uvsD KW - uvsE KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - DNA-Binding Proteins KW - Escherichia coli Proteins KW - Pyrimidine Dimers KW - Rec A Recombinases KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - UvrA protein, E coli KW - EC 3.6.1- KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - Index Medicus KW - Ultraviolet Rays KW - Bacterial Proteins -- genetics KW - Rec A Recombinases -- genetics KW - DNA Damage KW - Plasmids -- genetics KW - Pyrimidine Dimers -- metabolism KW - Bacterial Proteins -- metabolism KW - Adenosine Triphosphatases -- metabolism KW - DNA-Binding Proteins -- genetics KW - Rec A Recombinases -- metabolism KW - DNA, Bacterial -- radiation effects KW - Recombination, Genetic KW - Adenosine Triphosphatases -- genetics KW - DNA-Binding Proteins -- metabolism KW - DNA-Directed DNA Polymerase -- metabolism KW - Radiation Tolerance -- genetics KW - Micrococcaceae -- genetics KW - DNA Repair KW - Micrococcaceae -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76863638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=DNA+repair+in+the+extremely+radioresistant+bacterium+Deinococcus+radiodurans.&rft.au=Minton%2C+K+W&rft.aulast=Minton&rft.aufirst=K&rft.date=1994-07-01&rft.volume=13&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-12-30 N1 - Date created - 1994-12-30 N1 - Date revised - 2017-01-13 N1 - Gene symbol - mtcA; mtcB; pol; recA; uvrA; uvsC; uvsD; uvsE N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Impact of Infrastructure on Pakistan's Agricultural Sector AN - 61614363; 199502583 AB - Investment & infrastructure development are critical to the long-term viability of Pakistan's agricultural sector, which provides 25+% of the gross domestic product & employs 50+% of the labor force. Statistical analysis of investment suggests that Pakistan's rural infrastructure is deteriorating. Results from Granger Causality Tests for the relationship between infrastructure (& investment) & agricultural output reveal that: public investment has been a response to output growth, public rural works can increase output only in combination with other investment, investment is at least as important as infrastructure, & only private investment sparks a reciprocal relationship between investment & growth. These conclusions support the encouragement of more private investment. Better coordination of government programs & projects would be more beneficial than new programs. Intensive vs extensive agricultural development is also advocated. 7 Tables. E. Blackwell JF - Journal of Developing Areas AU - Looney, Robert E AD - National Security Affairs Naval Postgraduate School, Monterey CA 93943 Y1 - 1994/07// PY - 1994 DA - July 1994 SP - 469 EP - 486 VL - 28 IS - 4 SN - 0022-037X, 0022-037X KW - agricultural sector, investment/infrastructural development, Pakistan KW - statistical/test data KW - Pakistan KW - Agricultural Production KW - Agricultural Development KW - Investment KW - article KW - 8350: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61614363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Developing+Areas&rft.atitle=The+Impact+of+Infrastructure+on+Pakistan%27s+Agricultural+Sector&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1994-07-01&rft.volume=28&rft.issue=4&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Journal+of+Developing+Areas&rft.issn=0022037X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Agricultural Production; Pakistan; Agricultural Development; Investment ER - TY - JOUR T1 - Shoreline geomorphology of the Oxnard Plain from early U. S. Coast Survey maps AN - 52642455; 1997-078028 JF - Shore & Beach AU - Thompson, Warren C Y1 - 1994/07// PY - 1994 DA - July 1994 SP - 39 EP - 50 PB - American Shore and Beach Preservation Association, Berkeley, CA VL - 62 IS - 3 SN - 0037-4237, 0037-4237 KW - United States KW - eolian features KW - shore features KW - dunes KW - Ventura County California KW - Point Mugu KW - shorelines KW - Oxnard Plain KW - California KW - Southern California KW - wetlands KW - U. S. Coast Survey KW - Santa Monica Mountains KW - coastal dunes KW - 23:Geomorphology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52642455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Shore+%26+Beach&rft.atitle=Shoreline+geomorphology+of+the+Oxnard+Plain+from+early+U.+S.+Coast+Survey+maps&rft.au=Thompson%2C+Warren+C&rft.aulast=Thompson&rft.aufirst=Warren&rft.date=1994-07-01&rft.volume=62&rft.issue=3&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Shore+%26+Beach&rft.issn=00374237&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 15 N1 - PubXState - CA N1 - Document feature - 1 table, sketch maps N1 - Last updated - 2012-06-07 N1 - CODEN - SHBEAS N1 - SubjectsTermNotLitGenreText - California; coastal dunes; dunes; eolian features; Oxnard Plain; Point Mugu; Santa Monica Mountains; shore features; shorelines; Southern California; U. S. Coast Survey; United States; Ventura County California; wetlands ER - TY - JOUR T1 - Acid-catalyzed ethanolysis of temazepam in anhydrous and aqueous ethanol solutions. AN - 77129970; 9120829 AB - The benzodiazepines are a family of anxiolytic and hypnotic drugs. When taken concurrently with ethanol, a pharmacological interaction may occur, potentiating the central nervous system depression produced by either drug. In addition to this pharmacological interaction, this report describes a novel chemical reaction between temazepam (a 3-hydroxy-1,4-benzodiazepine) and ethanol under acidic conditions similar to those found in vivo, resulting in a 3-ethoxylated product. Optimal conditions, kinetics, equilibrium, and the mechanism of this acid-catalyzed ethanolysis are reported. The results raise the possibility that the ethanolysis reaction may occur in the stomach of people who consume alcohol and 3-hydroxy-1,4-benzodiazepine on a regular basis. The acid-catalyzed ethanol-drug reaction is a relatively unexplored area and may alter the pharmacological action of some drugs. JF - Journal of pharmaceutical sciences AU - Yang, S K AD - Department of Pharmacology, F. Edward Hébert School of Medicine, Uniformed Services, University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 898 EP - 902 VL - 83 IS - 6 SN - 0022-3549, 0022-3549 KW - Anti-Anxiety Agents KW - 0 KW - Ethanol KW - 3K9958V90M KW - Temazepam KW - CHB1QD2QSS KW - Index Medicus KW - Drug Interactions KW - Kinetics KW - Hydrolysis KW - Anti-Anxiety Agents -- metabolism KW - Ethanol -- metabolism KW - Temazepam -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77129970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=Acid-catalyzed+ethanolysis+of+temazepam+in+anhydrous+and+aqueous+ethanol+solutions.&rft.au=Yang%2C+S+K&rft.aulast=Yang&rft.aufirst=S&rft.date=1994-06-01&rft.volume=83&rft.issue=6&rft.spage=898&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=00223549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-24 N1 - Date created - 1997-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Specific DNA probes to detect Escherichia coli strains producing cytotoxic necrotising factor type 1 or type 2. AN - 76547350; 8006936 AB - Cytotoxic necrotising factors type 1 (CNF1) and type 2 (CNF2) are produced by many Escherichia coli strains isolated from man and animals with intestinal or extra-intestinal colibacillosis. In most laboratories, CNF-producing strains are detected by a cell cytotoxicity assay and confirmed with a neutralisation assay or a mouse footpad assay. In this study, we sought to determine whether DNA probes could detect clinical isolates of E. coli producing CNF2 or CNF1, or both, without the need for cell cultures or animal assays. Two internal fragments of the gene encoding CNF2 were used as DNA probes: a 875-bp XhoI-PstI DNA fragment and an adjacent 335-bp PstI-ClaI fragment. A positive response with both DNA probes was associated with CNF2-producing strains, whereas a positive response with only the 335-bp probe was associated with CNF1-producing strains. Results of colony hybridisation experiments with 185 clinical isolates of E. coli demonstrated that these DNA probes detected CNF2-producing strains with a sensitivity and specificity of 100% and CNF1-producing strains with a sensitivity and specificity of 99%. These two DNA probes should greatly facilitate epidemiological studies to assess the importance of CNF-producing strains as agents of diarrhoea and septicaemia. JF - Journal of medical microbiology AU - Oswald, E AU - Pohl, P AU - Jacquemin, E AU - Lintermans, P AU - Van Muylem, K AU - O'Brien, A D AU - Mainil, J AD - Uniformed Services University of the Health Sciences, Department of Microbiology, Bethesda, MD 20814-4799. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 428 EP - 434 VL - 40 IS - 6 SN - 0022-2615, 0022-2615 KW - Bacterial Toxins KW - 0 KW - Cytotoxins KW - DNA Probes KW - DNA, Bacterial KW - Escherichia coli Proteins KW - cytotoxic necrotizing factor type 1 KW - 106803-33-2 KW - Index Medicus KW - Animals KW - Genes, Bacterial KW - HeLa Cells KW - DNA, Bacterial -- chemistry KW - Humans KW - Restriction Mapping KW - Vero Cells KW - Nucleic Acid Hybridization KW - Autoradiography KW - Bacterial Toxins -- genetics KW - Escherichia coli Infections -- microbiology KW - Escherichia coli -- metabolism KW - Escherichia coli -- isolation & purification KW - Cytotoxins -- toxicity KW - Escherichia coli -- genetics KW - Cytotoxins -- genetics KW - Diarrhea -- microbiology KW - Bacterial Toxins -- toxicity KW - Bacterial Toxins -- biosynthesis KW - Cytotoxins -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76547350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+microbiology&rft.atitle=Specific+DNA+probes+to+detect+Escherichia+coli+strains+producing+cytotoxic+necrotising+factor+type+1+or+type+2.&rft.au=Oswald%2C+E%3BPohl%2C+P%3BJacquemin%2C+E%3BLintermans%2C+P%3BVan+Muylem%2C+K%3BO%27Brien%2C+A+D%3BMainil%2C+J&rft.aulast=Oswald&rft.aufirst=E&rft.date=1994-06-01&rft.volume=40&rft.issue=6&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+microbiology&rft.issn=00222615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-07-18 N1 - Date created - 1994-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo damage and recA-dependent repair of plasmid and chromosomal DNA in the radiation-resistant bacterium Deinococcus radiodurans. AN - 76527603; 8206827 AB - Deinococcus radiodurans R1 and other members of this genus share extraordinary resistance to the lethal and mutagenic effects of ionizing radiation. We have recently identified a RecA homolog in strain R1 and have shown that mutation of the corresponding gene causes marked radiosensitivity. We show here that following high-level exposure to gamma irradiation (1.75 megarads, the dose required to yield 37% of CFU for plateau-phase wild-type R1), the wild-type strain repairs > 150 double-strand breaks per chromosome, whereas a recA-defective mutant (rec30) repairs very few or none. A heterologous Escherichia coli-D. radiodurans shuttle plasmid (pMD68) was constructed and found to be retained in surviving D. radiodurans R1 and rec30 following any radiation exposure up to the highest dose tested, 3 megarads. Plasmid repair was monitored in vivo following irradiation with 1.75 megarads in both R1/pMD68 and rec30/pMD68. Immediately after irradiation, plasmids from both strains contained numerous breaks and failed to transform E. coli. While irradiation with 1.75 megarads was lethal to rec30 cultures, a small amount of supercoiled plasmid was regenerated, but it lacked the ability to transform E. coli. In contrast, wild-type cultures showed a cell division arrest of about 10 h, followed by exponential growth. Supercoiled plasmid was regenerated at normal levels, and it readily transformed E. coli. These studies show that D. radiodurans retains a heterologous plasmid following irradiation and repairs it with the same high efficiency as its chromosomal DNA, while the repair defect in rec30 prevents repair of the plasmid. Taken together, the results of this study suggest that plasmid DNA damaged in vivo in D. radiodurans is repaired by recA-dependent mechanisms similar to those employed in the repair of chromosomal DNA. JF - Journal of bacteriology AU - Daly, M J AU - Ouyang, L AU - Fuchs, P AU - Minton, K W AD - Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 3508 EP - 3517 VL - 176 IS - 12 SN - 0021-9193, 0021-9193 KW - recA KW - DNA, Bacterial KW - 0 KW - Rec A Recombinases KW - EC 2.7.7.- KW - Index Medicus KW - Chromosomes, Bacterial -- radiation effects KW - Plasmids -- metabolism KW - Gamma Rays -- adverse effects KW - Plasmids -- genetics KW - Transformation, Genetic KW - Chromosomes, Bacterial -- metabolism KW - Radiation Tolerance KW - Escherichia coli -- genetics KW - Genetic Vectors -- genetics KW - Dose-Response Relationship, Radiation KW - Plasmids -- radiation effects KW - Gram-Positive Cocci -- metabolism KW - DNA Repair KW - DNA Damage KW - Gram-Positive Cocci -- radiation effects KW - Rec A Recombinases -- metabolism KW - DNA, Bacterial -- metabolism KW - DNA, Bacterial -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76527603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=In+vivo+damage+and+recA-dependent+repair+of+plasmid+and+chromosomal+DNA+in+the+radiation-resistant+bacterium+Deinococcus+radiodurans.&rft.au=Daly%2C+M+J%3BOuyang%2C+L%3BFuchs%2C+P%3BMinton%2C+K+W&rft.aulast=Daly&rft.aufirst=M&rft.date=1994-06-01&rft.volume=176&rft.issue=12&rft.spage=3508&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-07-14 N1 - Date created - 1994-07-14 N1 - Date revised - 2017-01-13 N1 - Gene symbol - recA N1 - SuppNotes - Cited By: Nature. 1966 Jan 1;209(5018):49-52 [5925331] Gene. 1994 Apr 8;141(1):31-7 [8163172] J Bacteriol. 1975 Feb;121(2):422-8 [1112771] J Bacteriol. 1978 Apr;134(1):71-5 [649572] J Biochem. 1981 Sep;90(3):877-80 [7309705] Appl Environ Microbiol. 1984 May;47(5):915-8 [6378091] J Bacteriol. 1988 May;170(5):2126-35 [2834326] Radiat Res. 1974 Feb;57(2):260-75 [10874941] Nucleic Acids Res. 1988 Jul 11;16(13):6015-25 [2840639] Biochemistry. 1989 Apr 4;28(7):3120-4 [2742829] Plasmid. 1989 Sep;22(2):132-42 [2695951] J Bacteriol. 1990 Apr;172(4):2029-35 [2318808] J Mol Biol. 1990 Apr 5;212(3):433-6 [2182882] Nucleic Acids Res. 1990 Apr 25;18(8):2045-51 [2186374] J Bacteriol. 1990 Jun;172(6):2955-61 [2160933] Nucleic Acids Res. 1990 Dec 25;18(24):7425-32 [2175436] Gene. 1991 Jan 2;97(1):131-6 [1995425] Crit Rev Biochem Mol Biol. 1990;25(6):415-56 [2292186] Gene. 1991 Feb 1;98(1):45-52 [1849496] Mutat Res. 1991 Jul;249(1):189-93 [1829790] Cell Mol Biol. 1991;37(2):125-37 [1878922] Int J Radiat Biol. 1991 Oct;60(4):613-26 [1680142] J Bacteriol. 1991 Oct;173(19):6110-7 [1655698] Radiat Res. 1991 Aug;127(2):171-6 [1947001] Mol Cell Biol. 1992 Mar;12(3):1292-303 [1545810] Cancer Res. 1992 Oct 15;52(20):5668-73 [1394191] Plasmid. 1992 Nov;28(3):258-61 [1461940] J Bacteriol. 1993 Jan;175(1):277-87 [8416902] Mol Gen Genet. 1992 Dec;236(1):8-16 [1494354] Genetics. 1993 Mar;133(3):439-48 [8384141] Biochim Biophys Acta. 1971 Sep 30;247(1):38-53 [5160755] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of lovastatin on the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in brefeldin A-sensitive and -resistant cell lines. AN - 76482303; 8187826 AB - Lovastatin, a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, inhibits the biosynthesis of cholesterol and the prenylation of proteins. In this study, we have found that lovastatin inhibited the cytotoxicities of modeccin, ricin, Pseudomonas toxin, and diphtheria toxin in Vero and a brefeldin A (BFA)-resistant mutant of Vero cells (BER-40) to different extents. Among these toxins tested, the cytotoxicity of modeccin was most strongly inhibited by lovastatin in a dose-dependent manner. The protective effect of lovastatin was completely reversed by the addition of mevalonic acid, while the addition of cholesterol had no effect on the cytotoxicity of modeccin in lovastatin-treated cells. These results suggest that prenylated proteins are involved in the intoxication process of modeccin. The addition of cycloheximide to the growth medium also reversed the protective effect of lovastatin, suggesting a requirement of de novo protein synthesis for the protection by lovastatin against toxins. In contrast to Vero and BER-40 cells, no significant effect of lovastatin was observed in naturally BFA-resistant cell lines, PtK1 and MDCK cells, even though similar morphological changes and disassembly of the actin microfilaments were induced by lovastatin in these cell lines as observed in Vero and BER-40 cells. Lovastatin did not affect the binding and internalization of ricin and modeccin in Vero and BER-40 cells. Our results suggest that prenylated cellular proteins are involved in intracellular trafficking or processing of protein toxins, especially modeccin. In PtK1 and MDCK cells, such intracellular vesicle trafficking of protein toxins may be regulated by lovastatin-resistant mechanisms. JF - Experimental cell research AU - Oda, T AU - Wu, H C AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 329 EP - 337 VL - 212 IS - 2 SN - 0014-4827, 0014-4827 KW - Bacterial Toxins KW - 0 KW - Cyclopentanes KW - Diphtheria Toxin KW - Exotoxins KW - Lectins KW - Plant Lectins KW - Ribosome Inactivating Proteins, Type 2 KW - Virulence Factors KW - Brefeldin A KW - 20350-15-6 KW - modeccin KW - 65988-88-7 KW - Ricin KW - 9009-86-3 KW - Lovastatin KW - 9LHU78OQFD KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Animals KW - Actin Cytoskeleton -- ultrastructure KW - In Vitro Techniques KW - Dogs KW - Vero Cells KW - Cell Line KW - Ricin -- toxicity KW - Cyclopentanes -- pharmacology KW - Diphtheria Toxin -- toxicity KW - Exotoxins -- toxicity KW - Lovastatin -- pharmacology KW - Lectins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76482303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Effect+of+lovastatin+on+the+cytotoxicity+of+ricin%2C+modeccin%2C+Pseudomonas+toxin%2C+and+diphtheria+toxin+in+brefeldin+A-sensitive+and+-resistant+cell+lines.&rft.au=Oda%2C+T%3BWu%2C+H+C&rft.aulast=Oda&rft.aufirst=T&rft.date=1994-06-01&rft.volume=212&rft.issue=2&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-06-23 N1 - Date created - 1994-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - QBC malaria diagnosis: easily learned and effectively applied in a temporary military field laboratory. AN - 76858699; 7974669 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene AU - Bawden, M AU - Malone, J AU - Slaten, D AD - Uniformed Services University of the Health Sciences, Military Training Network, Maryland. PY - 1994 SP - 302 VL - 88 IS - 3 SN - 0035-9203, 0035-9203 KW - Reagent Kits, Diagnostic KW - 0 KW - Acridine Orange KW - F30N4O6XVV KW - Index Medicus KW - Plasmodium falciparum -- isolation & purification KW - Animals KW - Humans KW - Fluorescent Antibody Technique KW - Malaria, Falciparum -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76858699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+the+Royal+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=QBC+malaria+diagnosis%3A+easily+learned+and+effectively+applied+in+a+temporary+military+field+laboratory.&rft.au=Bawden%2C+M%3BMalone%2C+J%3BSlaten%2C+D&rft.aulast=Bawden&rft.aufirst=M&rft.date=1994-05-01&rft.volume=88&rft.issue=3&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Transactions+of+the+Royal+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=00359203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-12-20 N1 - Date created - 1994-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of mutations that inactivate the diphtheria toxin repressor gene (dtxR). AN - 76457567; 8168920 AB - The diphtheria toxin repressor (DtxR) is an iron-dependent regulator of diphtheria toxin production and iron uptake in Corynebacterium diphtheriae. It is activated in vitro by divalent metal ions including Fe2+, Cd2+, Co2+, Mn2+, Ni2+, and Zn2+. We characterized 20 different mutations in dtxR induced by bisulfite mutagenesis, 18 of which caused single-amino-acid substitutions in DtxR and two of which were chain-terminating mutations. Six of the amino acid replacements were clustered between residues 39 and 52 in a predicted helix-turn-helix motif that exhibits homology with several other repressors and is identified as the putative DNA-binding domain of DtxR. Three substitutions occurred within a predicted alpha-helical region with the sequence His-98-X3-Cys-102-X3-His-106 that resembles metal-binding motifs in several other proteins and is identified as the putative metal-binding site of DtxR. Several purified variants of DtxR with decreased repressor activity failed to bind in gel retardation assays to DNA fragments that contained the tox operator. A quantitative assay for binding of DtxR to 63Ni2+ was also developed. Scatchard analysis revealed that DtxR has a single class of high-affinity 63Ni(2+)-binding sites with a Kd of 2.11 x 10(-6) M and a maximum binding capacity of approximately 1.2 atoms of Ni2+ per DtxR monomer. The P39L, T40I, T44I, and R47H variants of DtxR exhibited normal to slightly decreased 63Ni(2+)-binding activity, but H106Y, which has an amino acid substitution in the presumed metal-binding domain, exhibited markedly decreased 63Ni(2+)-binding activity. JF - Infection and immunity AU - Wang, Z AU - Schmitt, M P AU - Holmes, R K AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1994/05// PY - 1994 DA - May 1994 SP - 1600 EP - 1608 VL - 62 IS - 5 SN - 0019-9567, 0019-9567 KW - dtxR KW - Bacterial Proteins KW - 0 KW - DNA-Binding Proteins KW - DtxR protein, Corynebacterium diphtheriae KW - Nickel KW - 7OV03QG267 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Blotting, Western KW - Base Sequence KW - Alleles KW - DNA -- metabolism KW - Molecular Sequence Data KW - Nickel -- metabolism KW - Amino Acid Sequence KW - DNA-Binding Proteins -- analysis KW - Bacterial Proteins -- genetics KW - DNA-Binding Proteins -- chemistry KW - Bacterial Proteins -- chemistry KW - DNA-Binding Proteins -- genetics KW - Bacterial Proteins -- analysis KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76457567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Characterization+of+mutations+that+inactivate+the+diphtheria+toxin+repressor+gene+%28dtxR%29.&rft.au=Wang%2C+Z%3BSchmitt%2C+M+P%3BHolmes%2C+R+K&rft.aulast=Wang&rft.aufirst=Z&rft.date=1994-05-01&rft.volume=62&rft.issue=5&rft.spage=1600&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-06-02 N1 - Date created - 1994-06-02 N1 - Date revised - 2017-01-13 N1 - Gene symbol - dtxR N1 - SuppNotes - Cited By: Biochemistry. 1989 Mar 7;28(5):2331-9 [2719955] Mol Microbiol. 1993 Jul;9(1):173-81 [8412663] Infect Immun. 1989 Oct;57(10):3221-5 [2506133] Proc Natl Acad Sci U S A. 1990 Aug;87(15):5968-72 [2116013] Annu Rev Biochem. 1977;46:69-94 [20040] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] J Bacteriol. 1978 Aug;135(2):511-6 [98519] J Virol. 1981 Mar;37(3):936-45 [6785449] Proc Natl Acad Sci U S A. 1982 Mar;79(5):1428-32 [6951187] Nature. 1982 Jul 29;298(5873):447-51 [6896364] Infect Immun. 1983 Dec;42(3):914-23 [6196297] Proc Natl Acad Sci U S A. 1985 Jan;82(2):483-7 [3881764] Nucleic Acids Res. 1985 May 10;13(9):3147-59 [3923442] Mol Gen Genet. 1985;200(1):110-3 [2993806] Biochemistry. 1987 Aug 25;26(17):5471-7 [2823881] Methods Enzymol. 1987;154:415-30 [3323815] J Bacteriol. 1988 Dec;170(12):5949-52 [3142864] J Biol Chem. 1989 Feb 5;264(4):1903-6 [2644244] Eur J Biochem. 1991 Apr 10;197(1):29-38 [1849822] Infect Immun. 1991 Jun;59(6):1899-904 [1828057] Microb Pathog. 1990 Oct;9(4):267-73 [2151460] Science. 1991 Jun 28;252(5014):1796-7 [1648261] Biochemistry. 1991 Aug 20;30(33):8201-10 [1868094] Infect Immun. 1991 Nov;59(11):3903-8 [1718867] Nature. 1991 Oct 24;353(6346):715-9 [1944532] Infect Immun. 1992 Jan;60(1):63-70 [1729197] J Bacteriol. 1992 Feb;174(4):1268-72 [1735717] Proc Natl Acad Sci U S A. 1992 May 15;89(10):4500-4 [1584782] Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5897-901 [1631071] EMBO J. 1992 Aug;11(8):3031-8 [1386307] Annu Rev Biochem. 1992;61:1053-95 [1497306] Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7576-80 [1502169] J Biol Chem. 1992 Oct 25;267(30):21761-4 [1400485] Microb Pathog. 1992 Aug;13(2):85-92 [1453929] Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8524-8 [8378326] Biochemistry. 1989 Mar 7;28(5):2340-4 [2497778] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A new class of anti-filariasis compounds: a preliminary look. AN - 76322938; 14620403 AB - Parasitic nematode worms which produce filariasis in humans place approximately one billion people at risk in more than 75 countries. More than 100 million people are infected with these diseases and are recognized as being of significant military importance. During World War II, filariasis was among the leading causes of medical evacuation from the entire South Pacific area. Agents available to treat the diseases exhibit significant toxicity. Better drugs are urgently needed. Data are reported from work using a Mongolian jird animal model on a new class of potential drugs, thiosemicarbazones. These compounds exhibit activity against the parasites which cause both lymphatic filariasis and the "onchocerciasis type" of the disease. JF - Military medicine AU - Kinnamon, K E AU - Engle, R R AU - Poon, B T AU - McCall, J W AU - Dzimianski, M T AD - School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. Y1 - 1994/05// PY - 1994 DA - May 1994 SP - 368 EP - 372 VL - 159 IS - 5 SN - 0026-4075, 0026-4075 KW - Filaricides KW - 0 KW - Index Medicus KW - Gerbillinae KW - Animals KW - Filariasis -- epidemiology KW - Dogs KW - Disease Models, Animal KW - Filariasis -- drug therapy KW - Cricetinae KW - Dipetalonema -- drug effects KW - Filaricides -- pharmacology KW - Brugia pahangi -- drug effects KW - Filaricides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76322938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=A+new+class+of+anti-filariasis+compounds%3A+a+preliminary+look.&rft.au=Kinnamon%2C+K+E%3BEngle%2C+R+R%3BPoon%2C+B+T%3BMcCall%2C+J+W%3BDzimianski%2C+M+T&rft.aulast=Kinnamon&rft.aufirst=K&rft.date=1994-05-01&rft.volume=159&rft.issue=5&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-12-16 N1 - Date created - 2003-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibers. AN - 76466738; 8170993 AB - Cytotoxic necrotizing factor type 2 (CNF2) produced by Escherichia coli strains isolated from intestinal and extraintestinal infections is a dermonecrotic toxin of 110 kDa. We cloned the CNF2 gene from a large plasmid carried by an Escherichia coli strain isolated from a lamb with septicemia. Hydropathy analysis of the deduced amino acid sequence revealed a largely hydrophilic protein with two potential hydrophobic transmembrane domains. The N-terminal half of CNF2 showed striking homology (27% identity and 80% conserved residues) to the N-terminal portion of Pasteurella multocida toxin. Methylamine protection experiments and immunofluorescence studies suggested that CNF2 enters the cytosol of the target cell through an acidic compartment and induces the reorganization of actin into stress fibers. Since the formation of stress fibers in eukaryotic cells involves Rho proteins, we radiolabeled these small GTP-binding proteins from CNF2-treated and control cells with a Rho-specific ADP-ribosyltransferase. The [32P]ADP-ribosylated Rho proteins from CNF2-treated cells migrated slightly more slowly in SDS/PAGE than did the labeled proteins from the control cells. This shift in mobility of Rho proteins in SDS/PAGE was also observed when CNF2 and the RhoA protein were coexpressed in E. coli. We propose that Rho proteins are the targets of CNF2 in mammalian cells. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Oswald, E AU - Sugai, M AU - Labigne, A AU - Wu, H C AU - Fiorentini, C AU - Boquet, P AU - O'Brien, A D AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1994/04/26/ PY - 1994 DA - 1994 Apr 26 SP - 3814 EP - 3818 VL - 91 IS - 9 SN - 0027-8424, 0027-8424 KW - Actins KW - 0 KW - Bacterial Toxins KW - Cytotoxins KW - Escherichia coli Proteins KW - cytotoxic necrotizing factor type 2 KW - cytotoxic necrotizing factor type 1 KW - 106803-33-2 KW - Adenosine Diphosphate Ribose KW - 20762-30-5 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - rho GTP-Binding Proteins KW - EC 3.6.5.2 KW - Index Medicus KW - Genes, Bacterial KW - Base Sequence KW - Sequence Alignment KW - Actin Cytoskeleton -- ultrastructure KW - Humans KW - Restriction Mapping KW - In Vitro Techniques KW - Molecular Sequence Data KW - Sequence Homology, Amino Acid KW - Adenosine Diphosphate Ribose -- metabolism KW - Cell Line KW - Cloning, Molecular KW - Bacterial Toxins -- genetics KW - GTP-Binding Proteins -- metabolism KW - Escherichia coli -- pathogenicity KW - Escherichia coli -- genetics KW - Cytotoxins -- genetics KW - Actins -- metabolism KW - Bacterial Toxins -- pharmacology KW - Cytotoxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76466738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Cytotoxic+necrotizing+factor+type+2+produced+by+virulent+Escherichia+coli+modifies+the+small+GTP-binding+proteins+Rho+involved+in+assembly+of+actin+stress+fibers.&rft.au=Oswald%2C+E%3BSugai%2C+M%3BLabigne%2C+A%3BWu%2C+H+C%3BFiorentini%2C+C%3BBoquet%2C+P%3BO%27Brien%2C+A+D&rft.aulast=Oswald&rft.aufirst=E&rft.date=1994-04-26&rft.volume=91&rft.issue=9&rft.spage=3814&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-06-01 N1 - Date created - 1994-06-01 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - U01097; GENBANK N1 - SuppNotes - Cited By: J Biol Chem. 1989 Jan 5;264(1):10-3 [2491843] Vet Microbiol. 1987 Oct;15(1-2):137-50 [3326246] Toxicon. 1988;26(11):1047-56 [3072687] FEMS Microbiol Lett. 1989 Mar;49(1):95-9 [2656399] EMBO J. 1989 Apr;8(4):1087-92 [2501082] J Clin Microbiol. 1989 May;27(5):983-8 [2663921] Mol Cell Biol. 1989 May;9(5):2058-66 [2501657] Proc Natl Acad Sci U S A. 1990 Jan;87(1):123-7 [2153282] J Clin Microbiol. 1990 Apr;28(4):694-9 [2185259] FEMS Microbiol Lett. 1990 Mar 15;56(3):279-84 [2187741] Mol Microbiol. 1990 May;4(5):821-30 [2201870] J Cell Biol. 1990 Sep;111(3):1001-7 [2118140] Nucleic Acids Res. 1990 Sep 11;18(17):5315-6 [2402474] Res Vet Sci. 1990 Nov;49(3):349-54 [2267427] FEBS Lett. 1990 Dec 17;277(1-2):59-64 [2269370] J Bacteriol. 1991 Mar;173(6):1920-31 [2001995] J Biol Chem. 1992 Feb 5;267(4):2600-4 [1733958] J Clin Microbiol. 1991 Nov;29(11):2522-7 [1774259] Eur J Biochem. 1992 Feb 15;204(1):57-68 [1740156] Mol Biol Cell. 1992 May;3(5):475-9 [1611153] Cell. 1992 Aug 7;70(3):389-99 [1643657] FEMS Microbiol Lett. 1992 Sep 15;75(2-3):155-9 [1398031] Exp Cell Res. 1992 Dec;203(2):321-8 [1459197] J Biol Chem. 1992 Dec 15;267(35):25296-303 [1334089] Nature. 1992 Dec 10;360(6404):540 [1281284] Res Vet Sci. 1993 May;54(3):290-8 [8337478] Infect Immun. 1993 Nov;61(11):4909-14 [8406895] Vet Res. 1993;24(4):311-5 [8220498] Mol Microbiol. 1993 Sep;9(6):1247-54 [7934938] J Gen Microbiol. 1974 Jul;83(0):95-111 [4606141] J Bacteriol. 1980 Feb;141(2):758-69 [6988390] Am J Vet Res. 1980 May;41(5):769-74 [6996544] Infect Immun. 1982 Mar;35(3):852-60 [6279518] J Mol Biol. 1982 May 5;157(1):105-32 [7108955] Infect Immun. 1983 Mar;39(3):1300-6 [6341235] Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 [6546423] Biochem Biophys Res Commun. 1984 Jan 30;118(2):587-93 [6367741] Microbiol Rev. 1984 Sep;48(3):199-221 [6436655] Gene. 1985;36(1-2):105-11 [3905511] Rev Esp Enferm Apar Dig. 1985 Aug;68(2):127-30 [4070734] J Clin Microbiol. 1987 Jan;25(1):146-9 [3539987] Ann Rech Vet. 1989;20(1):39-46 [2648944] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A novel protein, CSG2p, is required for Ca2+ regulation in Saccharomyces cerevisiae. AN - 76388609; 8125941 AB - Nineteen mutants that lost the ability to grow in 100 mM Ca2+ (but remained insensitive to 50 mM Sr2+) were identified in a screen of approximately 60,000 mutagenized yeast colonies. Cells carrying mutations in the CSG2 gene grow normally in low Ca2+ medium but have decreased growth rates when the Ca2+ concentration is above 10 mM. The csg2 mutant cells accumulate much higher levels of Ca2+ in a compartment that is exchangeable with extracellular Ca2+ but the nonexchangeable Ca2+ pool which predominates in wild-type cells is not influenced. Sr2+ influx is not increased in the csg2 mutant cells. Mg2+ decreases the amount of Ca2+ in the non-exchangeable pool without influencing the csg2-induced exchangeable Ca2+ pool. The data indicate that the csg2 mutation causes a selective increase in Ca2+ accumulation into a pool which is distinct from the vacuolar pool. The CSG2 protein consists of 410 amino acids, contains nine putative transmembrane segments, four potential sites for N-linked glycosylation, and a sequence with homology to the EF-hand Ca(2+)-binding site. JF - The Journal of biological chemistry AU - Beeler, T AU - Gable, K AU - Zhao, C AU - Dunn, T AD - Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1994/03/11/ PY - 1994 DA - 1994 Mar 11 SP - 7279 EP - 7284 VL - 269 IS - 10 SN - 0021-9258, 0021-9258 KW - CSG2 KW - CSG2 protein, S cerevisiae KW - 0 KW - Calcium-Binding Proteins KW - DNA, Fungal KW - Fungal Proteins KW - Membrane Proteins KW - Saccharomyces cerevisiae Proteins KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Membrane Proteins -- chemistry KW - Membrane Proteins -- metabolism KW - Amino Acid Sequence KW - Membrane Proteins -- genetics KW - Chromosome Mapping KW - Chromosomes, Fungal KW - Cloning, Molecular KW - Base Sequence KW - Escherichia coli KW - Molecular Sequence Data KW - Mutation KW - Protein Conformation KW - Saccharomyces cerevisiae -- genetics KW - Fungal Proteins -- chemistry KW - Calcium -- metabolism KW - Fungal Proteins -- metabolism KW - Saccharomyces cerevisiae -- metabolism KW - Saccharomyces cerevisiae -- growth & development KW - Fungal Proteins -- genetics KW - Calcium-Binding Proteins -- genetics KW - Calcium-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76388609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=A+novel+protein%2C+CSG2p%2C+is+required+for+Ca2%2B+regulation+in+Saccharomyces+cerevisiae.&rft.au=Beeler%2C+T%3BGable%2C+K%3BZhao%2C+C%3BDunn%2C+T&rft.aulast=Beeler&rft.aufirst=T&rft.date=1994-03-11&rft.volume=269&rft.issue=10&rft.spage=7279&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-04-12 N1 - Date created - 1994-04-12 N1 - Date revised - 2017-01-13 N1 - Gene symbol - CSG2 N1 - Genetic sequence - L24113; GENBANK N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Burden of Trafalgar: Decisive Battle and Naval Strategic Expectations on the Eve of World War I AN - 61398275; 9500472 AB - Considers the place of the "decisive battle" in naval strategic thinking during the two decades or so prior to WWI. Defining the decisive battle concept at the grand-strategic, strategic, & tactical levels of analysis, it is found that few, if any, naval battles merit the label "decisive" in the sense that the outcome of the fighting changed the course of history. This is true even for the turn-of-the-century navalist's apotheosis of decisiveness at sea: the Battle of Trafalgar in 1805. Yet, even though history had repeatedly shown that real war at sea is much more complicated than the ideal of battle, "another Trafalgar" became the dogmatic maxim of the machine age fleet planners a century later. This fixation was at the heart of the belligerents' failure to anticipate the true nature of the great war at sea. AA JF - The Journal of Strategic Studies AU - Breemer, Jan S AD - Dept National Security Affairs US Naval Postgraduate School, Monterey CA 93943 Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 33 EP - 62 VL - 17 IS - 1 SN - 0140-2390, 0140-2390 KW - naval strategic thinking, pre-WWI-era, "decisive battle" concept KW - Thinking KW - War KW - Turn of the Century KW - Military Service KW - United States of America KW - Strategies KW - article KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61398275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Strategic+Studies&rft.atitle=The+Burden+of+Trafalgar%3A+Decisive+Battle+and+Naval+Strategic+Expectations+on+the+Eve+of+World+War+I&rft.au=Breemer%2C+Jan+S&rft.aulast=Breemer&rft.aufirst=Jan&rft.date=1994-03-01&rft.volume=17&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Strategic+Studies&rft.issn=01402390&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSTSD5 N1 - SubjectsTermNotLitGenreText - United States of America; Military Service; Strategies; Thinking; Turn of the Century; War ER - TY - JOUR T1 - Polypharmacy. Pharmacokinetic perspectives. AN - 76444281; 8162659 JF - Clinical pharmacokinetics AU - Honig, P K AU - Cantilena, L R AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 85 EP - 90 VL - 26 IS - 2 SN - 0312-5963, 0312-5963 KW - Nonprescription Drugs KW - 0 KW - Pharmaceutical Preparations KW - Index Medicus KW - Humans KW - Nonprescription Drugs -- pharmacology KW - Pharmacokinetics KW - Nonprescription Drugs -- metabolism KW - Aging -- metabolism KW - Pharmaceutical Preparations -- metabolism KW - Drug Interactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76444281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacokinetics&rft.atitle=Polypharmacy.+Pharmacokinetic+perspectives.&rft.au=Honig%2C+P+K%3BCantilena%2C+L+R&rft.aulast=Honig&rft.aufirst=P&rft.date=1994-02-01&rft.volume=26&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacokinetics&rft.issn=03125963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-05-23 N1 - Date created - 1994-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cloning, sequence, and footprint analysis of two promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron. AN - 76359709; 8106325 AB - DtxR is an iron-dependent sequence-specific DNA-binding protein that binds to the tox operator, an inverted-repeat nucleotide sequence located upstream from the diphtheria toxin gene. In this study, two additional iron-regulated promoter/operator sequences (IRP1 and IRP2) that are controlled by DtxR were cloned from the chromosome of Corynebacterium diphtheriae and characterized. Operon fusions to lacZ were used to analyze expression from IRP1 and IRP2 in Escherichia coli. Transcription from both promoters was strongly repressed in high-iron medium in the presence of the cloned dtxR gene; however, transcription in the absence of dtxR was 50- to 100-fold greater, regardless of the iron concentration. Purified DtxR altered the electrophoretic mobility of DNA fragments carrying IRP1 or IRP2, and the nucleotide sequences of the two promoter/operator regions indicated that they are both homologous with the tox operator. DtxR protected an approximately 30-bp region on both IRP1 and IRP2 from DNase I digestion. A 19-bp consensus DtxR-binding site was derived from a comparison of the various DtxR-regulated operator/promoter sequences. Footprinting experiments using hydroxyl radicals and dimethyl sulfate demonstrated that DtxR interacted with these operators in a symmetrical manner, probably as a dimer or multimer. The deduced amino acid sequence of an open reading frame (ORF1) located downstream from IRP1 was homologous with a family of periplasmic proteins involved in iron transport in gram-negative bacteria and with the ferrichrome receptor, FhuD, from Bacillus subtilis. These findings suggest that ORF1 encodes a membrane-associated lipoprotein that may serve as the receptor for a ferric-siderophore complex in C. diphtheriae. JF - Journal of bacteriology AU - Schmitt, M P AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 1141 EP - 1149 VL - 176 IS - 4 SN - 0021-9193, 0021-9193 KW - dtxR KW - Bacterial Proteins KW - 0 KW - Carrier Proteins KW - Cations KW - DNA-Binding Proteins KW - Diphtheria Toxin KW - DtxR protein, Corynebacterium diphtheriae KW - Escherichia coli Proteins KW - Ferric Compounds KW - Membrane Proteins KW - Membrane Transport Proteins KW - Periplasmic Binding Proteins KW - Sulfuric Acid Esters KW - fhuD protein, E coli KW - 112002-32-1 KW - Hydroxyl Radical KW - 3352-57-6 KW - Deoxyribonuclease I KW - EC 3.1.21.1 KW - dimethyl sulfate KW - JW5CW40Z50 KW - Index Medicus KW - Carrier Proteins -- metabolism KW - Sequence Homology, Nucleic Acid KW - Carrier Proteins -- genetics KW - Ferric Compounds -- metabolism KW - Transcription, Genetic KW - Amino Acid Sequence KW - Ferric Compounds -- pharmacology KW - Membrane Proteins -- genetics KW - Sequence Analysis, DNA KW - Diphtheria Toxin -- genetics KW - Protein Binding KW - Cloning, Molecular KW - Base Sequence KW - Deoxyribonuclease I -- metabolism KW - Molecular Sequence Data KW - Sequence Homology, Amino Acid KW - Cations -- pharmacology KW - Operator Regions, Genetic -- genetics KW - Bacterial Proteins -- pharmacology KW - DNA-Binding Proteins -- pharmacology KW - Bacterial Proteins -- metabolism KW - Gene Expression Regulation, Bacterial -- drug effects KW - Corynebacterium diphtheriae -- genetics KW - Promoter Regions, Genetic -- genetics KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76359709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Cloning%2C+sequence%2C+and+footprint+analysis+of+two+promoter%2Foperators+from+Corynebacterium+diphtheriae+that+are+regulated+by+the+diphtheria+toxin+repressor+%28DtxR%29+and+iron.&rft.au=Schmitt%2C+M+P%3BHolmes%2C+R+K&rft.aulast=Schmitt&rft.aufirst=M&rft.date=1994-02-01&rft.volume=176&rft.issue=4&rft.spage=1141&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-21 N1 - Date created - 1994-03-21 N1 - Date revised - 2017-01-13 N1 - Gene symbol - dtxR N1 - Genetic sequence - U02634; GENBANK; U02617 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5897-901 [1631071] Methods Enzymol. 1991;208:380-413 [1664026] J Biol Chem. 1992 Oct 25;267(30):21761-4 [1400485] Mol Microbiol. 1992 Sep;6(17):2507-16 [1406286] Microb Pathog. 1992 Aug;13(2):85-92 [1453929] Clin Microbiol Rev. 1993 Apr;6(2):137-49 [8472246] J Bacteriol. 1993 May;175(9):2589-98 [8478325] Mol Microbiol. 1993 Apr;8(1):111-21 [8388528] J Bacteriol. 1993 Jun;175(11):3295-302 [8501033] Microbiol Rev. 1993 Jun;57(2):320-46 [8336670] Mol Microbiol. 1993 Jul;9(1):173-81 [8412663] J Virol. 1969 Jun;3(6):586-98 [4978942] Annu Rev Biochem. 1977;46:69-94 [20040] Infect Immun. 1977 Oct;18(1):203-9 [409685] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] J Bacteriol. 1978 Aug;135(2):511-6 [98519] Antimicrob Agents Chemother. 1980 Nov;18(5):814-21 [6255866] J Virol. 1981 Mar;37(3):936-45 [6785449] Anal Biochem. 1981 Jun;114(1):193-7 [6269464] J Bacteriol. 1983 Apr;154(1):245-52 [6403502] Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 [6546423] Microbiol Rev. 1984 Mar;48(1):60-93 [6371470] Infect Immun. 1984 Jul;45(1):143-9 [6429042] Annu Rev Biochem. 1984;53:293-321 [6236744] J Bacteriol. 1985 Sep;163(3):1114-9 [2411714] Proc Natl Acad Sci U S A. 1986 Aug;83(15):5469-73 [3090544] J Bacteriol. 1987 Jun;169(6):2624-30 [3294800] Microbiol Rev. 1987 Dec;51(4):509-18 [2963952] EMBO J. 1988 Jan;7(1):269-75 [3282882] J Mol Biol. 1988 Oct 20;203(4):875-84 [3062182] J Bacteriol. 1990 Jun;172(6):3496-9 [2111810] Annu Rev Biochem. 1990;59:933-69 [2197994] Proc Natl Acad Sci U S A. 1990 Aug;87(15):5968-72 [2116013] Infect Immun. 1991 Jun;59(6):1899-904 [1828057] Microb Pathog. 1990 Oct;9(4):267-73 [2151460] Infect Immun. 1991 Nov;59(11):3903-8 [1718867] J Bacteriol. 1992 Feb;174(4):1268-72 [1735717] Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7576-80 [1502169] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cholinergic basal forebrain transplants restore diminished metabolic activity in the somatosensory cortex of rats with acetylcholine depletion. AN - 76349113; 8301358 AB - It has been known for several years that stimulus-evoked metabolic activity is reduced in the somatosensory cortex of animals with basal forebrain lesions that deplete the neocortex of acetylcholine (ACh). During 2-deoxyglucose (2-DG) experiments, animals with unilateral basal forebrain lesions demonstrate a decreased response to somatic stimulation, while background metabolic activity in the surrounding cortical regions remains normal. In an attempt to ameliorate these deficits, we examined the ability of embryonic cholinergic basal forebrain transplants inserted into neocortex to innervate surrounding cortical regions and restore functional 2-DG activity in adult host rats previously depleted of ACh by basal forebrain lesions. To accomplish this goal, a series of experiments were conducted in which we (1) depleted the cerebral cortex of ACh by injecting an excitotoxin into the rat basal forebrain, (2) transplanted embryonic basal forebrain or embryonic neocortical (control) tissue into the ACh-depleted cortex and, (3) 6-12 months later, used the 2-DG metabolic mapping technique to examine effects of the transplants on metabolic activity evoked by whisker stimulation in rat somatosensory (barrel) cortex. Histochemical analysis revealed that acetylcholinesterase (AChE) staining within 2 mm of the basal forebrain transplants was similar in density to the contralateral normal hemisphere. AChE staining farther than 2 mm from the basal forebrain transplants and throughout hemispheres containing neocortical (control) transplants was greatly reduced, with few AChE-positive fibers present, a finding typical of cerebral cortex in basal forebrain-lesioned animals. Stimulus-evoked 2-DG uptake in barrels adjacent to the basal forebrain transplants, and therefore within AChE-rich territory, was similar to that in corresponding barrels identically activated in the contralateral hemisphere. 2-DG activity was reduced, however, in stimulated barrels outside the region of dense AChE-positive staining, as well as in all activated barrels in hemispheres containing control transplants of embryonic neocortex. These results indicate that transplantation of cell suspensions containing embryonic cholinergic basal forebrain, but not neocortex, can ameliorate basal forebrain lesion-induced deficits in functional activity, and that the restoration of activity is influenced by proximity to the transplant. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Jacobs, S E AU - Fine, A AU - Juliano, S L AD - Department of Anatomy and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 697 EP - 711 VL - 14 IS - 2 SN - 0270-6474, 0270-6474 KW - Carbon Radioisotopes KW - 0 KW - Neurotoxins KW - Ibotenic Acid KW - 2552-55-8 KW - Deoxyglucose KW - 9G2MP84A8W KW - Acetylcholinesterase KW - EC 3.1.1.7 KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Rats KW - Vibrissae -- innervation KW - Animals KW - Rats, Sprague-Dawley KW - Fetal Tissue Transplantation -- physiology KW - Physical Stimulation KW - Ibotenic Acid -- toxicity KW - Autoradiography KW - Neurotoxins -- toxicity KW - Acetylcholine -- metabolism KW - Cerebral Cortex -- drug effects KW - Prosencephalon -- metabolism KW - Cerebral Cortex -- transplantation KW - Cerebral Cortex -- metabolism KW - Acetylcholinesterase -- metabolism KW - Prosencephalon -- transplantation KW - Brain Tissue Transplantation -- physiology KW - Acetylcholinesterase -- analysis KW - Deoxyglucose -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76349113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Cholinergic+basal+forebrain+transplants+restore+diminished+metabolic+activity+in+the+somatosensory+cortex+of+rats+with+acetylcholine+depletion.&rft.au=Jacobs%2C+S+E%3BFine%2C+A%3BJuliano%2C+S+L&rft.aulast=Jacobs&rft.aufirst=S&rft.date=1994-02-01&rft.volume=14&rft.issue=2&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-10 N1 - Date created - 1994-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Neurosci 1994 Mar;14(3 Pt 2):followi N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The specific activities of Shiga-like toxin type II (SLT-II) and SLT-II-related toxins of enterohemorrhagic Escherichia coli differ when measured by Vero cell cytotoxicity but not by mouse lethality. AN - 76339629; 8300218 AB - Characteristically, enterohemorrhagic Escherichia coli (EHEC) strains produce Shiga-like toxin type I (SLT-I), SLT-II, or both of these immunologically distinct cytotoxins. No antigenic or receptor-binding variants of SLT-I have been identified, but a number of SLT-II-related toxins have been described. Because EHEC O91:H21 strain B2F1, which produces two SLT-II-related toxins, is exquisitely virulent in an orally infected, streptomycin-treated mouse model (oral 50% lethal dose [LD50], < 10 organisms), we asked whether the pathogenicity of strain B2F1 was a consequence of SLT-II-related toxin production. For this purpose, we compared the lethality of orally administered E. coli DH5 alpha (Strr) strains that produced different cytotoxic levels of SLT-II, SLT-IIvha (cloned from B2F1), SLT-IIvhb (also cloned from B2F1), or SLT-IIc (cloned from EHEC O157:H7 strain E32511) on Vero cells. We also calculated the specific activities of purified SLT-IIvhb and SLT-II in intraperitoneally injected mice and on Vero cells. The two purified toxins were equally toxic for mice, but SLT-IIvhb was approximately 100-fold less active than SLT-II on Vero cells and bound to the glycolipid receptor Gb3 with lower affinity than did SLT-II. In addition, characterization of SLT-II-related toxin-binding (B) subunit mutants generated in this study revealed that the reduced in vitro cytotoxic levels of the SLT-II-related toxins were due to Asn-16 in the B subunit. Taken together, these findings do not support the idea that B2F1 is uniquely virulent because of the in vivo toxicity of SLT-II-related toxins but do demonstrate differences in in vitro cytotoxic activity among the SLT-II group produced by human EHEC isolates. JF - Infection and immunity AU - Lindgren, S W AU - Samuel, J E AU - Schmitt, C K AU - O'Brien, A D AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 623 EP - 631 VL - 62 IS - 2 SN - 0019-9567, 0019-9567 KW - Bacterial Toxins KW - 0 KW - DNA, Bacterial KW - Enterotoxins KW - Glycolipids KW - Receptors, Cell Surface KW - Shiga Toxin 2 KW - Shiga-like toxin receptor KW - Index Medicus KW - Animals KW - Kidney Cortex -- pathology KW - Escherichia coli Infections -- pathology KW - Mice KW - Receptors, Cell Surface -- metabolism KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Gastrointestinal Hemorrhage -- etiology KW - DNA, Bacterial -- genetics KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Lethal Dose 50 KW - Vero Cells KW - Escherichia coli Infections -- etiology KW - Glycolipids -- metabolism KW - Male KW - Bacterial Toxins -- genetics KW - Bacterial Toxins -- metabolism KW - Enterotoxins -- metabolism KW - Escherichia coli -- pathogenicity KW - Escherichia coli -- genetics KW - Enterotoxins -- genetics KW - Bacterial Toxins -- toxicity KW - Enterotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76339629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=The+specific+activities+of+Shiga-like+toxin+type+II+%28SLT-II%29+and+SLT-II-related+toxins+of+enterohemorrhagic+Escherichia+coli+differ+when+measured+by+Vero+cell+cytotoxicity+but+not+by+mouse+lethality.&rft.au=Lindgren%2C+S+W%3BSamuel%2C+J+E%3BSchmitt%2C+C+K%3BO%27Brien%2C+A+D&rft.aulast=Lindgren&rft.aufirst=S&rft.date=1994-02-01&rft.volume=62&rft.issue=2&rft.spage=623&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-04 N1 - Date created - 1994-03-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1992 Feb 20;355(6362):748-50 [1741063] J Clin Microbiol. 1988 Oct;26(10):2127-31 [3053764] Microb Pathog. 1992 Apr;12(4):245-54 [1630295] Can J Microbiol. 1992 Jul;38(7):734-46 [1393838] Infect Immun. 1993 Feb;61(2):534-43 [8423084] Microb Pathog. 1987 Jul;3(1):21-30 [3143036] Infect Immun. 1989 Apr;57(4):1339-42 [2647636] J Infect Dis. 1989 Apr;159(4):774-7 [2647865] Microb Pathog. 1989 Feb;6(2):113-22 [2654533] J Biol Chem. 1989 Jul 25;264(21):12520-5 [2663859] J Infect Dis. 1989 Sep;160(3):469-75 [2668430] J Infect Dis. 1989 Dec;160(6):994-8 [2685131] J Bacteriol. 1990 Feb;172(2):653-8 [2404947] Infect Immun. 1990 Mar;58(3):611-8 [2155181] Microb Pathog. 1990 Jan;8(1):47-60 [2185397] Infect Immun. 1990 Aug;58(8):2438-45 [2196227] J Gen Microbiol. 1990 Jun;136(6):1125-35 [2200845] Infect Immun. 1990 Dec;58(12):3959-65 [2254023] Infect Immun. 1991 Mar;59(3):1065-73 [1997410] Vet Pathol. 1991 Jan;28(1):66-73 [1826800] FEMS Microbiol Lett. 1991 Mar 15;63(1):27-30 [2044938] J Clin Microbiol. 1991 Jul;29(7):1339-43 [1679436] J Clin Microbiol. 1991 Dec;29(12):2704-9 [1757536] Mol Microbiol. 1991 Aug;5(8):1817-22 [1766367] Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):524-8 [1731324] Microb Pathog. 1992 Sep;13(3):225-36 [1291844] Infect Immun. 1993 Aug;61(8):3392-402 [8335369] Infect Immun. 1993 Sep;61(9):3832-42 [8359904] J Clin Microbiol. 1993 Oct;31(10):2799-801 [8253989] Infect Immun. 1977 Dec;18(3):775-9 [338490] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] Eur J Clin Microbiol. 1982 Jun;1(3):186-92 [6756909] N Engl J Med. 1983 Mar 24;308(12):681-5 [6338386] J Mol Biol. 1983 Jun 5;166(4):557-80 [6345791] Ann Intern Med. 1984 Nov;101(5):624-6 [6385798] J Infect Dis. 1985 May;151(5):775-82 [3886804] Can Med Assoc J. 1985 Jul 1;133(1):37-8 [3891061] Infect Immun. 1986 Jul;53(1):135-40 [3522426] J Infect Dis. 1986 Aug;154(2):338-41 [3522760] J Pediatr. 1986 Aug;109(2):287-91 [3525791] J Biol Chem. 1987 Feb 5;262(4):1779-85 [3543013] J Biol Chem. 1987 Jun 25;262(18):8834-9 [3298243] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] Epidemiol Infect. 1987 Dec;99(3):613-24 [3322851] Methods Enzymol. 1987;154:367-82 [3323813] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] Infect Immun. 1988 Aug;56(8):1926-33 [3294179] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] Zentralbl Bakteriol. 1992 Jan;276(2):176-88 [1559006] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phosphate, nitrendipine and valinomycin increase the Ca2+/ATP coupling ratio of rat skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase. AN - 76336318; 8292624 AB - Nitrendipine and valinomycin act synergistically to stimulate ATP-dependent Ca2+ accumulation by rat skeletal muscle sarcoplasmic reticulum vesicles 3-fold. The stimulation is not caused by activation of the Ca(2+)-ATPase or by inhibition of the sarcoplasmic reticulum Ca2+ channel, but is due to an increased efficiency of transport by Ca(2+)-loaded vesicles. At low Ca2+ concentrations, nitrendipine+valinomycin inhibits Ca2+ uptake by increasing the Ca2+ KM but does not effect equilibrium Ca2+ binding to the Ca(2+)-ATPase (Kd = 0.75 microM). In the presence of 50 mM phosphate, nitrendipine+valinomycin increases the steady-state coupling ratio (Ca2+ accumulated per ATP hydrolyzed) from 0.6 to 1.9 by decreasing the rate of ATP hydrolysis by 72%, while reducing the Ca2+ accumulation rate by only 13%. The rates of both passive and Ca(2+)-ATPase-mediated Ca2+ release are reduced by nitrendipine+valinomycin. The data indicate that nitrendipine and valinomycin act directly on the Ca(2+)-ATPase to decrease the ATP hydrolysis rate, increase the Ca2+ KM, decrease Ca2+ efflux, and increase the Ca2+/ATP coupling ratio of Ca(2+)-loaded vesicles. JF - Biochimica et biophysica acta AU - Beeler, T J AU - Gable, K S AD - Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1994/01/19/ PY - 1994 DA - 1994 Jan 19 SP - 189 EP - 194 VL - 1189 IS - 2 SN - 0006-3002, 0006-3002 KW - Phosphates KW - 0 KW - Valinomycin KW - 2001-95-8 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Nitrendipine KW - 9B627AW319 KW - Calcium-Transporting ATPases KW - EC 3.6.3.8 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Sarcoplasmic Reticulum -- metabolism KW - Sarcoplasmic Reticulum -- drug effects KW - Drug Synergism KW - Calcium -- metabolism KW - Nitrendipine -- pharmacology KW - Valinomycin -- pharmacology KW - Phosphates -- pharmacology KW - Adenosine Triphosphate -- metabolism KW - Muscles -- enzymology KW - Calcium-Transporting ATPases -- metabolism KW - Muscles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76336318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Phosphate%2C+nitrendipine+and+valinomycin+increase+the+Ca2%2B%2FATP+coupling+ratio+of+rat+skeletal+muscle+sarcoplasmic+reticulum+Ca%282%2B%29-ATPase.&rft.au=Beeler%2C+T+J%3BGable%2C+K+S&rft.aulast=Beeler&rft.aufirst=T&rft.date=1994-01-19&rft.volume=1189&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-02-28 N1 - Date created - 1994-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Percentage of embryonal carcinoma and of vascular invasion predicts pathological stage in clinical stage I nonseminomatous testicular cancer. AN - 76326704; 8275469 AB - We analyzed 92 clinical stage I nonseminomatous testicular germ cell tumors for primary tumor histological factors that would distinguish true pathological stage I disease (N = 54) from those patients who harbored occult disease and actually were later found to have pathological stage II disease (N = 38). Primary tumor pathological material was analyzed for vascular invasion, lymphatic invasion, tunical invasion, and quantitative determination of percentage of the primary tumor composed of embryonal carcinoma, yolk sac carcinoma, teratoma, and seminoma. Univariate logistic regression analyses revealed that vascular invasion (P = 0.0001), percentage of embryonal carcinoma (P = 0.0001), lymphatic invasion (P = 0.0001), and tunical invasion (P = 0.0013) were higher in pathological stage II and that percentage of teratoma (P = 0.0001) and of yolk sac carcinoma (P = 0.0174) were higher in stage I. Percentage of seminoma was not significant. Individually, these parameters were able to correctly predict occult disease 66.3 to 80.4% of the time. In multivariate logistic regression analysis, only vascular invasion and percentage of embryonal carcinoma remained significant, and a model using these two variables was able to correctly predict stage 85.9% of the time. Vascular invasion and determination of percentage of embryonal carcinoma should be assessed for all clinical stage I nonseminomatous germ cell tumor patients and the model presented herein can be used clinically to predict the likelihood of occult disease and dictate therapy. JF - Cancer research AU - Moul, J W AU - McCarthy, W F AU - Fernandez, E B AU - Sesterhenn, I A AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1994/01/15/ PY - 1994 DA - 1994 Jan 15 SP - 362 EP - 364 VL - 54 IS - 2 SN - 0008-5472, 0008-5472 KW - Index Medicus KW - Neoplasm Invasiveness KW - Neoplasm Staging KW - Humans KW - Retroperitoneal Space KW - Lymph Node Excision KW - Male KW - Germinoma -- surgery KW - Testicular Neoplasms -- pathology KW - Carcinoma, Embryonal -- secondary KW - Carcinoma, Embryonal -- surgery KW - Germinoma -- pathology KW - Testicular Neoplasms -- surgery KW - Carcinoma, Embryonal -- pathology KW - Germinoma -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76326704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Percentage+of+embryonal+carcinoma+and+of+vascular+invasion+predicts+pathological+stage+in+clinical+stage+I+nonseminomatous+testicular+cancer.&rft.au=Moul%2C+J+W%3BMcCarthy%2C+W+F%3BFernandez%2C+E+B%3BSesterhenn%2C+I+A&rft.aulast=Moul&rft.aufirst=J&rft.date=1994-01-15&rft.volume=54&rft.issue=2&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-02-09 N1 - Date created - 1994-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The surgical and health care innovator: patents and marketing guidelines. AN - 85260753; pmid-8164873 AB - Many physicians and health professionals have had ideas for new devices but are reluctant to pursue the idea to production. Some abandon a sound innovation because of unfamiliarity with the intricate processes from concept to final marketing. The subject of surgical or medical innovation is not taught in medical schools or in residency training and few articles have appeared in the medical literature. This presentation is meant to guide the potential inventor from the concept stage through protection measures and the patent process to the final manufacture of a new device. It is hoped that this article will provide the innovator with a sound footing and stimulate him to contribute to medical technology and medical progress. Other disciplines (scientific, academic, and industry) might also be interested in these guidelines on patents and marketing strategies. JF - Military Medicine AU - Abramson, D J AD - Department of Surgery, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, MD 20814-4799. PY - 1994 SP - 68 EP - 74 VL - 159 IS - 1 SN - 0026-4075, 0026-4075 KW - United States KW - Surgical Equipment KW - Equipment and Supplies KW - Patents KW - Commerce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85260753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Medicine&rft.atitle=The+surgical+and+health+care+innovator%3A+patents+and+marketing+guidelines.&rft.au=Abramson%2C+D+J&rft.aulast=Abramson&rft.aufirst=D&rft.date=1994-01-01&rft.volume=159&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Military+Medicine&rft.issn=00264075&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Diaspirin crosslinked hemoglobin (DCLHb): control of pressor effect with anti-hypertensive agents. AN - 76884043; 7994405 AB - Diaspirin crosslinked hemoglobin (DCLHb) administration elevates mean arterial pressure (MAP). The purpose of this study was to determine whether commonly used antihypertensive agents could control this pressor effect in rats. Awake rats were injected intravenously (i.v.) with 280 mg/kg of DCLHb. Fifteen minutes later when MAP was 25-30% above baseline and heart rate (HR) was reciprocally decreased, prazosin (2 mg/kg;an alpha adrenergic blocker), nitroglycerine (NTG; 10-150 mcg/min; a nitrovasodilator), nicardipine (0.204-0.08 mg/hr; a calcium channel blocker) or labetalol (5 mg/kg; an alpha/beta adrenergic blocker) was administered i.v. All four classes of antihypertensive agents promptly restored MAP to baseline. Coincident with the return of MAP to baseline, HR was restored to baseline in prazosin and NTG treated animals, however, bradycardia persisted in those animals treated with nicardipine and labetalol, most likely due to the negative chronotropic properties of these agents. We conclude that the pressor effect of DCLHb can be readily controlled with at least four different classes of commonly used antihypertensive agents. JF - Artificial cells, blood substitutes, and immobilization biotechnology AU - Bilello, K AU - Schultz, S AU - Powell, C AU - Jaffin, J AU - Cole, F AU - Malcolm, D AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1994 PY - 1994 DA - 1994 SP - 819 EP - 825 VL - 22 IS - 3 SN - 1073-1199, 1073-1199 KW - Antihypertensive Agents KW - 0 KW - Blood Substitutes KW - Hemoglobins KW - diaspirin-cross-linked hemoglobin KW - Nicardipine KW - CZ5312222S KW - Nitroglycerin KW - G59M7S0WS3 KW - Aspirin KW - R16CO5Y76E KW - Labetalol KW - R5H8897N95 KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Rats KW - Animals KW - Nitroglycerin -- pharmacology KW - Prazosin -- pharmacology KW - Hypertension -- etiology KW - Labetalol -- pharmacology KW - Nicardipine -- pharmacology KW - Hypertension -- drug therapy KW - Hemoglobins -- toxicity KW - Aspirin -- analogs & derivatives KW - Aspirin -- toxicity KW - Blood Pressure -- drug effects KW - Antihypertensive Agents -- pharmacology KW - Blood Substitutes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76884043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+cells%2C+blood+substitutes%2C+and+immobilization+biotechnology&rft.atitle=Diaspirin+crosslinked+hemoglobin+%28DCLHb%29%3A+control+of+pressor+effect+with+anti-hypertensive+agents.&rft.au=Bilello%2C+K%3BSchultz%2C+S%3BPowell%2C+C%3BJaffin%2C+J%3BCole%2C+F%3BMalcolm%2C+D&rft.aulast=Bilello&rft.aufirst=K&rft.date=1994-01-01&rft.volume=22&rft.issue=3&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Artificial+cells%2C+blood+substitutes%2C+and+immobilization+biotechnology&rft.issn=10731199&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-17 N1 - Date created - 1995-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of nicotine on body weight and plasma insulin in female and male rats. AN - 76647331; 8057754 AB - There is an inverse relationship between nicotine and body weight. It has been proposed that this inverse relationship is partially mediated by insulinergic actions, but the effect of nicotine on insulin only has been reported for male rats. The present experiment was designed to examine the effect of nicotine administration on body weight and plasma insulin in female and male rats. In addition, the effects of anesthesia prior to sacrifice on plasma insulin were examined. Nicotine reduced body weight and plasma insulin in female and male rats. In addition, the use of an anesthetic prior to sacrifice was associated with higher plasma insulin levels for male rats. These findings are consistent with the interpretation that insulinergic mechanisms play a role in the nicotine-body weight relationship. JF - Life sciences AU - Saah, M I AU - Raygada, M AU - Grunberg, N E AD - Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1994 PY - 1994 DA - 1994 SP - 925 EP - 931 VL - 55 IS - 12 SN - 0024-3205, 0024-3205 KW - Insulin KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Rats KW - Anesthesia -- adverse effects KW - Animals KW - Rats, Sprague-Dawley KW - Analysis of Variance KW - Sex Factors KW - Infusion Pumps, Implantable KW - Male KW - Female KW - Nicotine -- toxicity KW - Insulin -- blood KW - Body Weight -- drug effects KW - Nicotine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76647331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Effects+of+nicotine+on+body+weight+and+plasma+insulin+in+female+and+male+rats.&rft.au=Saah%2C+M+I%3BRaygada%2C+M%3BGrunberg%2C+N+E&rft.aulast=Saah&rft.aufirst=M&rft.date=1994-01-01&rft.volume=55&rft.issue=12&rft.spage=925&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-09-15 N1 - Date created - 1994-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype. AN - 76331095; 8288531 AB - Salmonella typhimurium ST39 exhibits reduced virulence in mice and decreased survival in mouse macrophages compared with the parent strain SL3201. Strain ST39 is nonmotile, carries an indeterminate deletion in and near the flgB operon, and is defective in the mviS (mouse virulence Salmonella) locus. In flagellum-defective strains, the flgM gene product of S. typhimurium negatively regulates flagellar genes by inhibiting the activity of FliA, the flagellin-specific sigma factor. In this study, flgM of wild-type S. typhimurium LT2 was found to complement the mviS defect in ST39 for virulence in mice and for enhanced survival in macrophages. Transduction of flgM::Tn10dCm into the parent strain SL3201 resulted in attenuation of mouse virulence and decreased survival in macrophages. However, a flgM-fliA double mutant was fully virulent in mice and survived in macrophages at wild-type levels. Thus, the absolute level of FliA activity appears to affect the virulence of S. typhimurium SL3201 in mice. DNA hybridization studies showed that flgM-related sequences were present in species other than Salmonella typhimurium and that sequences related to that of fliA were common among members of the family Enterobacteriaceae. Our results demonstrate that flgM and fliA, two genes previously shown to regulate flagellar operons, are also involved in the regulation of expression of virulence of S. typhimurium and that this system may not be unique to the genus Salmonella. JF - Journal of bacteriology AU - Schmitt, C K AU - Darnell, S C AU - Tesh, V L AU - Stocker, B A AU - O'Brien, A D AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1994/01// PY - 1994 DA - January 1994 SP - 368 EP - 377 VL - 176 IS - 2 SN - 0021-9193, 0021-9193 KW - Bacterial Proteins KW - 0 KW - FliA protein, Bacteria KW - Recombinant Fusion Proteins KW - Sigma Factor KW - FlgM protein, Bacteria KW - 142462-45-1 KW - Index Medicus KW - Recombinant Fusion Proteins -- biosynthesis KW - Animals KW - Salmonella Infections, Animal -- genetics KW - Amino Acid Sequence KW - Mice KW - Cell Survival KW - Phenotype KW - Base Sequence KW - Macrophages, Peritoneal -- microbiology KW - Virulence -- genetics KW - Genetic Complementation Test KW - Mice, Inbred C57BL KW - Molecular Sequence Data KW - Promoter Regions, Genetic -- genetics KW - Sequence Homology, Amino Acid KW - Species Specificity KW - Bacteriophage T7 -- genetics KW - Mutagenesis, Insertional KW - Gene Expression Regulation, Bacterial KW - Sigma Factor -- genetics KW - Bacterial Proteins -- genetics KW - Bacterial Proteins -- biosynthesis KW - Salmonella typhimurium -- pathogenicity KW - Flagella -- physiology KW - Salmonella typhimurium -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76331095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Mutation+of+flgM+attenuates+virulence+of+Salmonella+typhimurium%2C+and+mutation+of+fliA+represses+the+attenuated+phenotype.&rft.au=Schmitt%2C+C+K%3BDarnell%2C+S+C%3BTesh%2C+V+L%3BStocker%2C+B+A%3BO%27Brien%2C+A+D&rft.aulast=Schmitt&rft.aufirst=C&rft.date=1994-01-01&rft.volume=176&rft.issue=2&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-02-24 N1 - Date created - 1994-02-24 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - U03631; GENBANK N1 - SuppNotes - Cited By: J Bacteriol. 1992 Jan;174(2):486-91 [1530848] Nature. 1981 May 21;291(5812):238-9 [7015147] Microb Pathog. 1991 Jun;10(6):493-9 [1665537] Mol Microbiol. 1992 Feb;6(4):459-69 [1560774] Infect Immun. 1992 Aug;60(8):3287-95 [1639496] Mol Microbiol. 1992 Nov;6(21):3149-57 [1453955] Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11978-82 [1465428] J Bacteriol. 1993 Jun;175(11):3361-71 [8501040] J Bacteriol. 1993 Jun;175(11):3468-79 [8501051] J Immunol. 1983 Dec;131(6):3006-13 [6358358] Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 [6546423] Gene. 1983 Dec;26(1):101-6 [6323249] Infect Immun. 1984 Dec;46(3):814-8 [6389363] Infect Immun. 1984 Dec;46(3):819-25 [6389364] Proc Natl Acad Sci U S A. 1985 Feb;82(4):1074-8 [3156376] Proc Natl Acad Sci U S A. 1986 Jul;83(14):5189-93 [3523484] J Bacteriol. 1986 Dec;168(3):1315-8 [3536871] J Bacteriol. 1992 Feb;174(3):857-66 [1732219] Proc Natl Acad Sci U S A. 1987 Sep;84(18):6422-4 [3306678] Proc Natl Acad Sci U S A. 1989 Feb;86(3):830-4 [2644646] Science. 1989 Feb 24;243(4894 Pt 1):1059-62 [2646710] Infect Immun. 1989 Nov;57(11):3276-80 [2680969] Infect Immun. 1990 Jan;58(1):137-43 [2152887] J Bacteriol. 1990 Feb;172(2):741-7 [2404955] Mol Microbiol. 1989 Dec;3(12):1833-41 [2695752] J Gen Microbiol. 1989 Sep;135(9):2561-7 [2697751] J Bacteriol. 1990 May;172(5):2485-90 [2185222] Mol Gen Genet. 1990 Apr;221(2):139-47 [2196428] J Bacteriol. 1990 Dec;172(12):7188-99 [2123866] J Bacteriol. 1991 Apr;173(7):2301-10 [1848842] J Bacteriol. 1991 Jul;173(14):4482-92 [1906064] J Bacteriol. 1991 Oct;173(20):6453-9 [1655712] J Exp Med. 1966 Oct 1;124(4):601-19 [5922286] N Engl J Med. 1970 Sep 24;283(13):686-91 [4916913] Proc Natl Acad Sci U S A. 1972 Aug;69(8):2110-4 [4559594] Proc Natl Acad Sci U S A. 1975 Mar;72(3):1184-8 [1055375] Infect Immun. 1982 Dec;38(3):948-52 [7152679] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Restoration of the DNA damage resistance of Deinococcus radiodurans DNA polymerase mutants by Escherichia coli DNA polymerase I and Klenow fragment. AN - 76319035; 7504195 AB - Deinococcus radiodurans and other species of this genus share extreme resistance to ionizing radiation and many other agents that damage DNA. D. radiodurans mutant strains defective in a deinococcal DNA polymerase that is homologous with E. coli DNA polymerase I are highly sensitive to DNA damage. In the current work we have inquired whether E. coli DNA Pol I can substitute for D. radiodurans Pol in partially or fully restoring to pol- D. radiodurans mutants the extreme DNA damage-resistance typical of this organism. The E. coli polA gene or a 5'-truncated polA gene that encodes the Klenow fragment were introduced and expressed in two different D. radiodurans pol- mutants: Strain 303, which is a chemically mutagenized derivative, and strain 6R1A, which is isogenic with wild-type D. radiodurans except for an insertional mutation within the pol gene. Expression of E. coli polA in both of these mutants fully restored wild-type resistance to ionizing- and UV254-radiation and mitomycin-C exposure. Expression of the Klenow fragment-encoding gene restored wild-type resistance to D. radiodurans strain 303, but only partial resistance to strain 6R1A. The observation that E. coli DNA Pol I is as effective as D. radiodurans Pol in restoring damage resistance, indicates that D. radiodurans DNA Pol per se does not have special properties that are essential or prerequisite for expression of the extreme resistance of D. radiodurans. JF - Mutation research AU - Gutman, P D AU - Fuchs, P AU - Minton, K W AD - Department of Pathology, F. E. Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1994/01// PY - 1994 DA - January 1994 SP - 87 EP - 97 VL - 314 IS - 1 SN - 0027-5107, 0027-5107 KW - polA KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - DNA Polymerase I KW - EC 2.7.7.- KW - Index Medicus KW - Bacterial Proteins -- genetics KW - Electrophoresis, Polyacrylamide Gel KW - Sequence Homology, Nucleic Acid KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology KW - Plasmids KW - DNA Damage -- genetics KW - Transformation, Genetic KW - DNA, Bacterial -- genetics KW - Molecular Sequence Data KW - Suppression, Genetic KW - Cell Survival -- radiation effects KW - Sequence Homology, Amino Acid KW - Mutagenesis, Insertional KW - DNA Repair -- genetics KW - Gram-Positive Cocci -- enzymology KW - DNA Polymerase I -- genetics KW - Gram-Positive Cocci -- radiation effects KW - Genes, Bacterial -- genetics KW - Gram-Positive Cocci -- genetics KW - DNA Polymerase I -- chemistry KW - Radiation Tolerance -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76319035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Restoration+of+the+DNA+damage+resistance+of+Deinococcus+radiodurans+DNA+polymerase+mutants+by+Escherichia+coli+DNA+polymerase+I+and+Klenow+fragment.&rft.au=Gutman%2C+P+D%3BFuchs%2C+P%3BMinton%2C+K+W&rft.aulast=Gutman&rft.aufirst=P&rft.date=1994-01-01&rft.volume=314&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-01-03 N1 - Date created - 1994-01-03 N1 - Date revised - 2017-01-13 N1 - Gene symbol - polA N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Mental Health among Army Spouses: A Study of the Relationship between Institutional Factors and Well Being T2 - International Sociological Association AN - 61719105; 94S29402 AB - A large-scale questionnaire survey of US Army spouses worldwide (N = approximately 5,000 respondents [Rs], 97% female, including spouses of both officers & enlisted soldiers) provided data relating to mental health. Analysis indicates that Rs' well-being is strongly related to their perception of Army attitudes toward spouses & families (whether or not this perception is accurate). If the Army is perceived as caring, supportive, & concerned about the military family, the R is more likely to manifest positive mental health as well as general satisfaction with military life. Specific problems & dissatisfaction with certain aspects of military life are less significant than the perception of institutional attitudes. Theoretically, this analysis illuminates the importance of social psychological factors (eg, perception of others' attitudes) in individual feelings of well being & life satisfaction. JF - International Sociological Association AU - Rosenberg, Florence R Y1 - 1994///0, PY - 1994 DA - 0, 1994 KW - Army spouses' mental health/life satisfaction KW - US Army family support perceptions KW - questionnaire survey KW - Social Perception KW - Military Personnel KW - Life Satisfaction KW - Social Support KW - Mental Health KW - Spouses KW - proceeding KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61719105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=International+Sociological+Association&rft.atitle=Mental+Health+among+Army+Spouses%3A+A+Study+of+the+Relationship+between+Institutional+Factors+and+Well+Being&rft.au=Rosenberg%2C+Florence+R&rft.aulast=Rosenberg&rft.aufirst=Florence&rft.date=1994-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 1994 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Broadcasting the USGS scientific visualization workshop over the Internet multicast backbone AN - 50237446; 1994-038870 JF - Open-File Report - U. S. Geological Survey AU - Brutzman, Donald P AU - Lawson, Carol A AU - Bennett, Pauline C Y1 - 1994 PY - 1994 DA - 1994 SP - 19 PB - U. S. Geological Survey, Reston, VA SN - 0196-1497, 0196-1497 KW - data handling KW - data processing KW - computer networks KW - USGS KW - Internet KW - 15:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50237446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open-File+Report+-+U.+S.+Geological+Survey&rft.atitle=Broadcasting+the+USGS+scientific+visualization+workshop+over+the+Internet+multicast+backbone&rft.au=Brutzman%2C+Donald+P%3BLawson%2C+Carol+A%3BBennett%2C+Pauline+C&rft.aulast=Brutzman&rft.aufirst=Donald&rft.date=1994-01-01&rft.volume=&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Open-File+Report+-+U.+S.+Geological+Survey&rft.issn=01961497&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Scientific visualization workshop N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 1994-01-01 N1 - Availability - U. S. Geol. Surv., Denver, CO, United States N1 - PubXState - VA N1 - Last updated - 2014-03-14 N1 - CODEN - XGROAG N1 - SubjectsTermNotLitGenreText - computer networks; data handling; data processing; Internet; USGS ER - TY - JOUR T1 - Use of bathymetry terrain for robotics visualization in an underwater virtual world AN - 50232463; 1994-038869 JF - Open-File Report - U. S. Geological Survey AU - Brutzman, Donald P AU - Lawson, Carol A AU - Bennett, Pauline C Y1 - 1994 PY - 1994 DA - 1994 SP - 18 PB - U. S. Geological Survey, Reston, VA SN - 0196-1497, 0196-1497 KW - visualization KW - underwater methods KW - robots KW - marine methods KW - digital simulation KW - marine geology KW - data processing KW - bathymetry KW - USGS KW - instruments KW - 20:Applied geophysics KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50232463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open-File+Report+-+U.+S.+Geological+Survey&rft.atitle=Use+of+bathymetry+terrain+for+robotics+visualization+in+an+underwater+virtual+world&rft.au=Brutzman%2C+Donald+P%3BLawson%2C+Carol+A%3BBennett%2C+Pauline+C&rft.aulast=Brutzman&rft.aufirst=Donald&rft.date=1994-01-01&rft.volume=&rft.issue=&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Open-File+Report+-+U.+S.+Geological+Survey&rft.issn=01961497&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Scientific visualization workshop N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 1994-01-01 N1 - Availability - U. S. Geol. Surv., Denver, CO, United States N1 - PubXState - VA N1 - Last updated - 2014-03-14 N1 - CODEN - XGROAG N1 - SubjectsTermNotLitGenreText - bathymetry; data processing; digital simulation; instruments; marine geology; marine methods; robots; underwater methods; USGS; visualization ER - TY - JOUR T1 - Sequencing, targeted mutagenesis and expression of a recA gene required for the extreme radioresistance of Deinococcus radiodurans AN - 16778679; 3743628 AB - Deinococcus radiodurans and other members of the same genus share extreme resistance to ionizing radiation and many other agents that damage DNA. A DNA damage-sensitive and natural transformation-deficient strain generated by chemical mutagenesis (strain rec30) was found to be defective in a gene that has extended homology with recA of Escherichia coli. Upon transformation with a chromosomal DNA fragment that contained this deinococcal recA gene from wild-type (wt) D. radiodurans both DNA damage resistance and full transformation competence were restored in the rec30 mutant. Targeted insertional mutagenesis of the deinococcal recA gene was used to construct a mutant isogenic with the wt. The insertional mutant was phenotypically indistinguishable from strain rec30, indicating that the recA defect alone was responsible for observed phenotypic alterations. For example, in the case of ionizing radiation, the D sub(37) of the wt was about 1.75 Mrad, while the D sub(37) of rec30 and the insertional mutant were both 25 krad, a 70-fold decrease. Evidence is presented that expression of the deinococcal recA gene in E. coli is lethal, suggesting that the mode of interaction of the deinococcal RecA protein with nucleic acids or other cellular proteins differs at least in part from RecA of E. coli. JF - Gene AU - Gutman, P D AU - Carroll, J D AU - Masters, C I AU - Minton, K W AD - Dep. Pathol., USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA Y1 - 1994 PY - 1994 DA - 1994 SP - 31 EP - 37 VL - 141 IS - 1 SN - 0378-1119, 0378-1119 KW - recA gene KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - cloning KW - nucleotide sequence KW - mutagenesis KW - Deinococcus radiodurans KW - N 14640:Structure & sequence KW - G 07321:GENERAL KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16778679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Sequencing%2C+targeted+mutagenesis+and+expression+of+a+recA+gene+required+for+the+extreme+radioresistance+of+Deinococcus+radiodurans&rft.au=Gutman%2C+P+D%3BCarroll%2C+J+D%3BMasters%2C+C+I%3BMinton%2C+K+W&rft.aulast=Gutman&rft.aufirst=P&rft.date=1994-01-01&rft.volume=141&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Deinococcus radiodurans; nucleotide sequence; mutagenesis; cloning ER - TY - JOUR T1 - Numerical studies of the beta effect in tropical cyclone motion. Part II: Zonal mean flow effects AN - 16733315; 3715106 AB - The motion of tropical vortices in east-west mean flows is studied with the barotropic vorticity equation on the beta plane. The vorticity equation is integrated numerically from an initially symmetric vortex embedded in (i) a linear shear flow or (ii) a parabolic jet. The first experiment with flow (i) has beta = 0 and it is linearized about the mean flow. The vortex is distorted by the mean flow so that the even Fourier components around the vortex grow, but the vortex does not move. When nonlinear effects are included the distortion is damped in the inner part of the vortex, but wavenumber two grows in the outer region. The addition of the beta effect causes the vortex to move in the same direction as the no mean flow solution provided the mean flow advection is removed from the trajectories. The trajectory for the anticyclonic mean flow is significantly longer than the cyclonic and no mean flow trajectories, which are about equal. For mean flow (ii), with the same absolute vorticity gradient as beta but on an f plane, the vortex has a much shorter trajectory and a more westerly direction of movement than the no mean flow solution with beta. This effect comes from the advective distortion of the vortex, which projects onto wavenumber one in the disturbance vorticity equation. It is shown with other experiments that beta has a stronger effect on vortex motion than the relative vorticity gradient. JF - Journal of the Atmospheric Sciences AU - Williams, R T AU - Chan, JC-L AD - Dep. Meteorol., Nav. Postgrad. Sch., NPS (MR/Wu/pj), Monterey, CA 93943-5100, USA Y1 - 1994 PY - 1994 DA - 1994 SP - 1065 EP - 1076 VL - 51 IS - 8 SN - 0022-4928, 0022-4928 KW - air flow over water KW - flow KW - tropical cyclones KW - tropical meteorology KW - ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Marine KW - numerical analysis KW - mathematical models KW - cyclones KW - atmospheric physics KW - storms KW - Q2 09241:General KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16733315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Atmospheric+Sciences&rft.atitle=Numerical+studies+of+the+beta+effect+in+tropical+cyclone+motion.+Part+II%3A+Zonal+mean+flow+effects&rft.au=Williams%2C+R+T%3BChan%2C+JC-L&rft.aulast=Williams&rft.aufirst=R&rft.date=1994-01-01&rft.volume=51&rft.issue=8&rft.spage=1065&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Atmospheric+Sciences&rft.issn=00224928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - numerical analysis; atmospheric physics; mathematical models; tropical meteorology; storms; cyclones; air flow over water; tropical cyclones; flow; Marine ER - TY - JOUR T1 - Elimination of trace endotoxin protein from rough chemotype LPS AN - 16643182; 3642782 AB - The phenol-chloroform-petroleum ether (PCP) extraction is the method of choice for isolating LPS chemotypes from rough mutant bacteria. However, we have observed that a high percentage of PCP-purified LPS preparations contain trace levels of protein contaminants, and these protein contaminants may exhibit endotoxin-like activity. To obtain protein-free rough LPS, a modified phenol-water extraction procedure was developed for use as a final step to follow PCP extraction. Using this procedure, Salmonella minnesota Ra, Rc, Rd and Re LPS were recovered in yields of 82-100% from the original PCP-extracted preparations. Yields were determined by recovery of KDO and supported by analysis of silver stained SDS-PAGE gels. Although the original PCP-purified chemotypes were contaminated by major 41, 38.5, 29.5, 23, 17 and 14 kDa proteins (detected by Western blotting and gold staining), the repurified LPS contained no detectable protein. The repurified LPS retained all of its original bioactivity as defined by the ability to stimulate normal C3H/OuJ macrophages to secrete TNF. The importance of utilizing repurified LPS in biologic studies was illustrated by the loss of > 99% of activity when repurified LPS was used to stimulate TNF secretion by LPS 'hyporesponsive' C3H/HeJ macrophages. JF - Journal of Endotoxin Research AU - Manthey, CL AU - Vogel, S N AD - Dep. Microbiol. and Immunol., USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA Y1 - 1994 PY - 1994 DA - 1994 SP - 84 EP - 91 VL - 1 IS - 2 SN - 0968-0519, 0968-0519 KW - lipopolysaccharides KW - Microbiology Abstracts B: Bacteriology KW - endotoxins KW - Salmonella minnesota KW - macrophages KW - extraction KW - activation KW - J 02730:Carbohydrates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16643182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=Elimination+of+trace+endotoxin+protein+from+rough+chemotype+LPS&rft.au=Manthey%2C+CL%3BVogel%2C+S+N&rft.aulast=Manthey&rft.aufirst=CL&rft.date=1994-01-01&rft.volume=1&rft.issue=2&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Salmonella minnesota; extraction; endotoxins; activation; macrophages ER - TY - JOUR T1 - Evidence of a turbidity current in Monterey submarine canyon associated with the 1989 Loma Prieta earthquake AN - 13665458; S199851493 AB - Movements of bottom-deployed acoustic transponders used to navigate free-falling oceanographic instruments in the Monterey submarine canyon provided evidence of a turbidity current passing through the canyon following the Loma Prieta earthquake of October 1989. Tectonically-induced sediment transport was detected at measuring sites located along the canyon at distances of 55, 130 and 190 km from the canyon head. At the first site a transponder located in the axis of the canyon was carried 1.9 km down the axis. Other transponders on the sides of the canyon gave evidence of sediment slumping towards the canyon axis. Movements of transponders were interpreted in terms of the inferred turbidity current. JF - Continental Shelf Research AU - Garfield, N AU - Rago, T A AU - Schnebele, K J AU - Collins, CA AD - Naval Postgraduate School, Monterey, Calif. Y1 - 1994 PY - 1994 DA - 1994 SP - 673 EP - 686 VL - 14 IS - 6 SN - 0278-4343, 0278-4343 KW - Instrumentation KW - Submarine KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13665458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Continental+Shelf+Research&rft.atitle=Evidence+of+a+turbidity+current+in+Monterey+submarine+canyon+associated+with+the+1989+Loma+Prieta+earthquake&rft.au=Garfield%2C+N%3BRago%2C+T+A%3BSchnebele%2C+K+J%3BCollins%2C+CA&rft.aulast=Garfield&rft.aufirst=N&rft.date=1994-01-01&rft.volume=14&rft.issue=6&rft.spage=673&rft.isbn=&rft.btitle=&rft.title=Continental+Shelf+Research&rft.issn=02784343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Case Study. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics. AN - 76244722; 8126255 AB - The object of this study was to examine prospectively the effects of itraconazole on the pharmacokinetics and electrocardiographic repolarization pharmacodynamics (QTc intervals) of single-dose terfenadine in six healthy volunteers. It was designed as a prospective cohort study with each subject serving as his own control, set in an outpatient cardiology clinic. The participants were six healthy volunteers (two men, four women; ages 24-35) not taking any prescription or over-the-counter medications. Single-dose terfenadine administration (120 mg) was accompanied by pharmacokinetic profiles and serial determination of the QTc interval for 12 hours. The subjects then began daily oral itraconazole (200 mg each morning) for 7 days. Repeat pharmacokinetic and pharmacodynamic determinations were made after administration of a second dose (120 mg) of terfenadine while receiving itraconazole. The main outcome measures were terfenadine and acid metabolite serum concentrations; corrected QT intervals as determined by 12-lead electrocardiogram (ECG); and presence or absence of late potentials as determined by signal-averaged ECGs over 150 cardiac cycles. There were significant changes in the pharmacokinetic parameters of acid metabolite after treatment with itraconazole. All subjects had detectable levels of unmetabolized terfenadine after addition of itraconazole, which was associated with QT prolongation. There was no evidence of late depolarization as manifested by an increase in QRS duration found using signal-averaged electrocardiography. Itraconazole influences the metabolism of terfenadine in normal volunteers and results in the accumulation of unmetabolized parent drug associated with altered cardiac repolarization. This drug combination should be avoided. JF - Journal of clinical pharmacology AU - Honig, P K AU - Wortham, D C AU - Hull, R AU - Zamani, K AU - Smith, J E AU - Cantilena, L R AD - Division of Clinical Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1993/12// PY - 1993 DA - December 1993 SP - 1201 EP - 1206 VL - 33 IS - 12 SN - 0091-2700, 0091-2700 KW - Itraconazole KW - 304NUG5GF4 KW - Terfenadine KW - 7BA5G9Y06Q KW - Index Medicus KW - Drug Interactions KW - Humans KW - Adult KW - Male KW - Female KW - Itraconazole -- pharmacology KW - Terfenadine -- pharmacology KW - Terfenadine -- pharmacokinetics KW - Heart -- drug effects KW - Electrocardiography -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76244722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Itraconazole+affects+single-dose+terfenadine+pharmacokinetics+and+cardiac+repolarization+pharmacodynamics.&rft.au=Honig%2C+P+K%3BWortham%2C+D+C%3BHull%2C+R%3BZamani%2C+K%3BSmith%2C+J+E%3BCantilena%2C+L+R&rft.aulast=Honig&rft.aufirst=P&rft.date=1993-12-01&rft.volume=33&rft.issue=12&rft.spage=1201&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-04-13 N1 - Date created - 1994-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An epidemiologic method for assessing the effectiveness of hearing conservation programs using audiometric data. AN - 85261388; pmid-8284053 AB - A hearing conservation program (HCP) must include audiometric monitoring. In keeping with this requirement, enormous bodies of audiometric data have been accumulated. However, only a limited number of methods are available for using audiometric data to assess HCP effectiveness. This study illustrates an epidemiologic method. The risk of developing hearing loss (measured by the standard threshold shift) was compared between study and reference populations using the risk ratio. The study population had an increased risk of nearly 3-fold. Epidemiologic risk comparison methods, using reference populations, offer an alternative to current methods for HCP evaluation using audiometric data. JF - Military Medicine AU - Adera, T AU - Donahue, A M AU - Malit, B D AU - Gaydos, J C AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. PY - 1993 SP - 698 EP - 701 VL - 158 IS - 11 SN - 0026-4075, 0026-4075 KW - Hearing Loss, Noise-Induced KW - Epidemiologic Methods KW - Human KW - Adult KW - Aged KW - Middle Age KW - Occupational Diseases KW - Female KW - Male KW - Noise, Occupational KW - Audiometry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85261388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Medicine&rft.atitle=An+epidemiologic+method+for+assessing+the+effectiveness+of+hearing+conservation+programs+using+audiometric+data.&rft.au=Adera%2C+T%3BDonahue%2C+A+M%3BMalit%2C+B+D%3BGaydos%2C+J+C&rft.aulast=Adera&rft.aufirst=T&rft.date=1993-11-01&rft.volume=158&rft.issue=11&rft.spage=698&rft.isbn=&rft.btitle=&rft.title=Military+Medicine&rft.issn=00264075&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mineralogy and related properties of hydrothermal soils of Yellowstone National Park, Wyoming AN - 52827266; 1996-047643 JF - Agronomy Abstracts AU - Wilson, M A AU - Rodman, A W AU - Thoma, D P AU - Shovic, H AU - Anonymous Y1 - 1993/11// PY - 1993 DA - November 1993 SP - 308 PB - American Society of Agronomy, Madison, WI VL - 85 SN - 0375-5495, 0375-5495 KW - United States KW - soils KW - silicates KW - rhyolites KW - volcanic rocks KW - clastic sediments KW - igneous rocks KW - vegetation KW - till KW - solution KW - hydrothermal conditions KW - Wyoming KW - physical properties KW - mineral composition KW - aluminosilicates KW - saturation KW - Yellowstone National Park KW - sediments KW - pH KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52827266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Agronomy+Abstracts&rft.atitle=Mineralogy+and+related+properties+of+hydrothermal+soils+of+Yellowstone+National+Park%2C+Wyoming&rft.au=Wilson%2C+M+A%3BRodman%2C+A+W%3BThoma%2C+D+P%3BShovic%2C+H%3BAnonymous&rft.aulast=Wilson&rft.aufirst=M&rft.date=1993-11-01&rft.volume=85&rft.issue=&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Agronomy+Abstracts&rft.issn=03755495&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Society of Agronomy, Crop Science Society of America and Soil Science Society of America; 1993 annual meetings N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - WI N1 - Last updated - 2012-06-07 N1 - CODEN - AGABBE N1 - SubjectsTermNotLitGenreText - aluminosilicates; clastic sediments; hydrothermal conditions; igneous rocks; mineral composition; pH; physical properties; rhyolites; saturation; sediments; silicates; soils; solution; till; United States; vegetation; volcanic rocks; Wyoming; Yellowstone National Park ER - TY - JOUR T1 - Profile of Escherichia coli O157:H7 pathogen responsible for hamburger-borne outbreak of hemorrhagic colitis and hemolytic uremic syndrome in Washington. AN - 76101600; 8253989 AB - We analyzed Escherichia coli O157:H7 isolates from stool samples of five patients who had bloody diarrhea and were infected during a large food-borne outbreak of hemorrhagic colitis in Washington state. The isolates were assessed for Shiga-like toxin profile, adherence and plasmid traits, mouse virulence, capsule, and enterohemolysin production. The profiles of the five isolates were indistinguishable from each other and similar to that of E. coli O157:H7 strain EDL933, an organism responsible for a similar hamburger-associated food poisoning episode in 1982. JF - Journal of clinical microbiology AU - O'Brien, A D AU - Melton, A R AU - Schmitt, C K AU - McKee, M L AU - Batts, M L AU - Griffin, D E AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1993/10// PY - 1993 DA - October 1993 SP - 2799 EP - 2801 VL - 31 IS - 10 SN - 0095-1137, 0095-1137 KW - Bacterial Toxins KW - 0 KW - Shiga Toxin 2 KW - Index Medicus KW - Virulence KW - Animals KW - Washington KW - Bacterial Toxins -- analysis KW - Humans KW - Adult KW - Mice KW - Child KW - Adolescent KW - Male KW - Female KW - Hemolytic-Uremic Syndrome -- etiology KW - Meat -- poisoning KW - Gastrointestinal Hemorrhage -- etiology KW - Gastrointestinal Hemorrhage -- epidemiology KW - Food Microbiology KW - Escherichia coli -- pathogenicity KW - Hemolytic-Uremic Syndrome -- epidemiology KW - Disease Outbreaks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76101600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Profile+of+Escherichia+coli+O157%3AH7+pathogen+responsible+for+hamburger-borne+outbreak+of+hemorrhagic+colitis+and+hemolytic+uremic+syndrome+in+Washington.&rft.au=O%27Brien%2C+A+D%3BMelton%2C+A+R%3BSchmitt%2C+C+K%3BMcKee%2C+M+L%3BBatts%2C+M+L%3BGriffin%2C+D+E&rft.aulast=O%27Brien&rft.aufirst=A&rft.date=1993-10-01&rft.volume=31&rft.issue=10&rft.spage=2799&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-01-10 N1 - Date created - 1994-01-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 1983 Jan 1;1(8314-5):76 [6129412] Infect Immun. 1993 Sep;61(9):3832-42 [8359904] Lancet. 1983 Mar 26;1(8326 Pt 1):702 [6132054] J Clin Microbiol. 1983 Sep;18(3):512-20 [6355145] J Infect Dis. 1987 Jul;156(1):175-82 [3298451] Infect Immun. 1987 Dec;55(12):3117-25 [3316033] Ann Intern Med. 1988 Nov 1;109(9):705-12 [3056169] Infect Immun. 1989 Apr;57(4):1290-8 [2647635] J Clin Microbiol. 1989 Nov;27(11):2559-64 [2681256] J Infect Dis. 1989 Dec;160(6):994-8 [2685131] Infect Immun. 1990 Dec;58(12):3959-65 [2254023] Infect Immun. 1991 Mar;59(3):1065-73 [1997410] Mol Microbiol. 1992 Feb;6(3):411-7 [1552854] Curr Microbiol. 1992 Jul;25(1):9-17 [1369498] Infect Immun. 1993 Aug;61(8):3392-402 [8335369] N Engl J Med. 1983 Mar 24;308(12):681-5 [6338386] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Processing of lipid-modified prolipoprotein requires energy and sec gene products in vivo. AN - 76025540; 8407783 AB - The kinetics of processing of glyceride-modified prolipoprotein that accumulated in globomycin-treated Escherichia coli has been found to be affected by sec mutations, i.e., secA, secE, secY, secD, and secF, and by metabolic poisons which affect proton motive force (PMF). The effect of sec mutations on processing of glyceride-modified prolipoprotein in vivo was not due to a secondary effect on PMF. Neither a secF mutation nor metabolic poisons affected the processing of previously accumulated proOmpA protein in vivo, suggesting that the requirements for functional sec gene products and PMF are specific to the processing of lipoprotein precursors by signal peptidase II. JF - Journal of bacteriology AU - Kosic, N AU - Sugai, M AU - Fan, C K AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1993/10// PY - 1993 DA - October 1993 SP - 6113 EP - 6117 VL - 175 IS - 19 SN - 0021-9193, 0021-9193 KW - sec KW - secA KW - secD KW - secE KW - secF KW - secY KW - Anti-Bacterial Agents KW - 0 KW - Arsenates KW - Azides KW - Bacterial Outer Membrane Proteins KW - Escherichia coli Proteins KW - Lipoproteins KW - Lpp protein, E coli KW - Peptides KW - Protein Precursors KW - Sulfur Radioisotopes KW - Tritium KW - 10028-17-8 KW - Carbonyl Cyanide m-Chlorophenyl Hydrazone KW - 555-60-2 KW - globomycin KW - 67076-74-8 KW - Sodium Azide KW - 968JJ8C9DV KW - Proline KW - 9DLQ4CIU6V KW - Methionine KW - AE28F7PNPL KW - arsenic acid KW - N7CIZ75ZPN KW - Index Medicus KW - Genotype KW - Proline -- metabolism KW - Anti-Bacterial Agents -- metabolism KW - Arsenates -- pharmacology KW - Kinetics KW - Energy Metabolism -- drug effects KW - Methionine -- metabolism KW - Azides -- pharmacology KW - Mutagenesis KW - Carbonyl Cyanide m-Chlorophenyl Hydrazone -- pharmacology KW - Genes, Bacterial KW - Escherichia coli -- metabolism KW - Protein Precursors -- metabolism KW - Bacterial Outer Membrane Proteins -- biosynthesis KW - Protein Processing, Post-Translational KW - Escherichia coli -- drug effects KW - Escherichia coli -- genetics KW - Bacterial Outer Membrane Proteins -- metabolism KW - Lipoproteins -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76025540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Processing+of+lipid-modified+prolipoprotein+requires+energy+and+sec+gene+products+in+vivo.&rft.au=Kosic%2C+N%3BSugai%2C+M%3BFan%2C+C+K%3BWu%2C+H+C&rft.aulast=Kosic&rft.aufirst=N&rft.date=1993-10-01&rft.volume=175&rft.issue=19&rft.spage=6113&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-11-16 N1 - Date created - 1993-11-16 N1 - Date revised - 2017-01-13 N1 - Gene symbol - sec; secA; secD; secE; secF; secY N1 - SuppNotes - Cited By: Eur J Biochem. 1969 Oct;10(3):426-38 [4899922] J Bacteriol. 1992 Apr;174(8):2511-6 [1556071] J Mol Biol. 1976 Jul 5;104(3):541-55 [781293] J Antibiot (Tokyo). 1978 Nov;31(11):1203-5 [721715] J Biol Chem. 1980 Mar 10;255(5):2123-30 [6986388] J Biol Chem. 1980 Aug 25;255(16):7973-7 [6995457] Cell. 1981 Sep;25(3):765-72 [7026050] J Biol Chem. 1982 May 10;257(9):5177-82 [7040395] Proc Natl Acad Sci U S A. 1982 Apr;79(7):2255-9 [7048314] Cell. 1983 Mar;32(3):789-97 [6339072] J Bacteriol. 1983 Apr;154(1):253-60 [6403503] J Biol Chem. 1984 Sep 10;259(17):11114-20 [6381496] J Biol Chem. 1985 Dec 15;260(29):15925-31 [2999144] J Bacteriol. 1987 Mar;169(3):1286-90 [3029032] J Bacteriol. 1987 Jun;169(6):2373-9 [2438267] Anal Biochem. 1987 Nov 1;166(2):368-79 [2449095] Genetics. 1988 Apr;118(4):571-9 [3284784] J Bacteriol. 1988 Sep;170(9):4001-7 [2842297] J Biol Chem. 1989 Jan 5;264(1):437-42 [2535843] J Bacteriol. 1989 Jan;171(1):585-7 [2644209] Genes Dev. 1989 Jul;3(7):1035-44 [2673920] J Bacteriol. 1989 Oct;171(10):5536-41 [2551889] J Bioenerg Biomembr. 1990 Jun;22(3):291-310 [2202721] J Bioenerg Biomembr. 1990 Jun;22(3):451-71 [2202727] EMBO J. 1990 Oct;9(10):3209-16 [2170107] Proc Natl Acad Sci U S A. 1990 Nov;87(21):8227-31 [2146683] Mol Microbiol. 1991 Jan;5(1):19-22 [1673017] Annu Rev Biochem. 1991;60:101-24 [1831965] J Biol Chem. 1991 Sep 15;266(26):17667-72 [1894646] J Biochem. 1974 Aug;76(2):251-61 [4154322] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cross-shore transport on a naturally barred beach AN - 50151067; 1995-035222 JF - Eos, Transactions, American Geophysical Union AU - Thornton, E AU - Humiston, R AU - Birkemeier, W AU - Anonymous Y1 - 1993/10// PY - 1993 DA - October 1993 SP - 340 EP - 341 PB - American Geophysical Union, Washington, DC VL - 74 IS - 43, Suppl. SN - 0096-3941, 0096-3941 KW - currents KW - bedload KW - beaches KW - shore features KW - sediment transport KW - ocean waves KW - bars KW - velocity KW - bathymetry KW - nearshore environment KW - ocean currents KW - 06A:Sedimentary petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50151067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Cross-shore+transport+on+a+naturally+barred+beach&rft.au=Thornton%2C+E%3BHumiston%2C+R%3BBirkemeier%2C+W%3BAnonymous&rft.aulast=Thornton&rft.aufirst=E&rft.date=1993-10-01&rft.volume=74&rft.issue=43%2C+Suppl.&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1993 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - bars; bathymetry; beaches; bedload; currents; nearshore environment; ocean currents; ocean waves; sediment transport; shore features; velocity ER - TY - JOUR T1 - Conserved sites in the 5'-3' exonuclease domain of Escherichia coli DNA polymerase. AN - 20204676; 8739457 JF - Nucleic Acids Research AU - Gutman, P D AU - Minton, K W AD - Department of Pathology, F.E. Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1993/09/11/ PY - 1993 DA - 1993 Sep 11 SP - 4406 EP - 4407 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 21 IS - 18 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - DNA-directed DNA polymerase KW - Escherichia coli KW - exonuclease KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20204676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Conserved+sites+in+the+5%27-3%27+exonuclease+domain+of+Escherichia+coli+DNA+polymerase.&rft.au=Gutman%2C+P+D%3BMinton%2C+K+W&rft.aulast=Gutman&rft.aufirst=P&rft.date=1993-09-11&rft.volume=21&rft.issue=18&rft.spage=4406&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA-directed DNA polymerase; exonuclease; Escherichia coli ER - TY - JOUR T1 - Calcium channel blockers in the treatment of hypertension. AN - 75926396; 8362695 AB - Physicians need to weigh the efficacy, adverse effects and cost of first-line antihypertensive agents. Calcium channel blockers lower blood pressure, improve coronary blood flow and depress cardiac contractility by relaxing smooth muscle and cardiac muscle. They have beneficial or neutral effects in hypertensive patients with angina, asthma, chronic obstructive pulmonary disease, postural hypotension, peripheral vascular disease, depression, sexual dysfunction, diabetes and hyperlipidemia. The major adverse effect of some calcium channel blockers is that they may worsen congestive heart failure in some patients. Because calcium channel blockers are metabolized in the liver, the dosage must be lowered in the elderly and in patients with hepatic disease. Diltiazem, verapamil and nifedipine represent prototypes of the three classes of calcium channel blockers, each with slightly different effects. JF - American family physician AU - Raspa, R F AU - Wilson, C C AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1993/09/01/ PY - 1993 DA - 1993 Sep 01 SP - 461 EP - 470 VL - 48 IS - 3 SN - 0002-838X, 0002-838X KW - Calcium Channel Blockers KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Calcium Channel Blockers -- adverse effects KW - Calcium Channel Blockers -- therapeutic use KW - Calcium Channel Blockers -- pharmacokinetics KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75926396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=Calcium+channel+blockers+in+the+treatment+of+hypertension.&rft.au=Raspa%2C+R+F%3BWilson%2C+C+C&rft.aulast=Raspa&rft.aufirst=R&rft.date=1993-09-01&rft.volume=48&rft.issue=3&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-09-27 N1 - Date created - 1993-09-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Am Fam Physician 1993 Nov 15;48(7):1236 Am Fam Physician 1994 Feb 1;49(2):339 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Virulence of enterohemorrhagic Escherichia coli O91:H21 clinical isolates in an orally infected mouse model. AN - 75920717; 8359904 AB - Escherichia coli K-12 strains producing high levels of Shiga-like toxin type II (SLT-II) but not SLT-I were previously shown to be virulent in an orally infected, streptomycin-treated mouse model. In this investigation, we tested the virulence of several SLT-II-producing enterohemorrhagic E. coli (EHEC) isolates from patients with hemorrhagic colitis or hemolytic uremic syndrome. All of the strains tested were able to colonize the mouse intestine. However, only two strains were consistently virulent for mice: O91:H21 strain B2F1 (Strr), which was previously shown to carry two copies of slt-II-related toxins, and O91:H21 strain H414-36/89 (Strr), which was found in this study to contain three genes from the slt-II group. The oral 50% lethal doses of strains B2F1 (Strr) and H414-36/89 (Strr) when fed to streptomycin-treated mice were less than 10 bacteria. Histological sections from moribund mice fed the O91:H21 strains demonstrated extensive renal tubular necrosis; however, hematological results were not consistent with a diagnosis of hemolytic uremic syndrome. The central role of SLT in the virulence of the O91:H21 EHEC strains was supported by the finding that streptomycin-treated mice preinoculated with monoclonal antibody specific for SLT-II survived oral challenge with either B2F1 (Strr) or H414-36/89 (Strr). The basis for the variation in virulence among the SLT-II-producing EHEC strains tested was not determined. However, a correlation between the capacity of an EHEC strain to grow in small intestinal mucus and lethality in the streptomycin-treated mice was observed. JF - Infection and immunity AU - Lindgren, S W AU - Melton, A R AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1993/09// PY - 1993 DA - September 1993 SP - 3832 EP - 3842 VL - 61 IS - 9 SN - 0019-9567, 0019-9567 KW - slt-II KW - Bacterial Toxins KW - 0 KW - Enterotoxins KW - Shiga Toxin 2 KW - Index Medicus KW - Virulence KW - Animals KW - Humans KW - Immunization, Passive KW - Lethal Dose 50 KW - Mice KW - Mouth -- microbiology KW - Male KW - Bacterial Toxins -- genetics KW - Escherichia coli Infections -- microbiology KW - Escherichia coli Infections -- immunology KW - Escherichia coli -- pathogenicity KW - Escherichia coli -- genetics KW - Escherichia coli Infections -- pathology KW - Escherichia coli Infections -- blood KW - Bacterial Toxins -- toxicity KW - Enterotoxins -- toxicity KW - Escherichia coli -- growth & development KW - Bacterial Toxins -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75920717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Virulence+of+enterohemorrhagic+Escherichia+coli+O91%3AH21+clinical+isolates+in+an+orally+infected+mouse+model.&rft.au=Lindgren%2C+S+W%3BMelton%2C+A+R%3BO%27Brien%2C+A+D&rft.aulast=Lindgren&rft.aufirst=S&rft.date=1993-09-01&rft.volume=61&rft.issue=9&rft.spage=3832&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-09-29 N1 - Date created - 1993-09-29 N1 - Date revised - 2017-01-13 N1 - Gene symbol - slt-II N1 - SuppNotes - Cited By: N Engl J Med. 1983 Mar 24;308(12):681-5 [6338386] J Clin Microbiol. 1990 Mar;28(3):540-5 [2182671] Ann Intern Med. 1984 Nov;101(5):624-6 [6385798] Science. 1984 Nov 9;226(4675):694-6 [6387911] J Infect Dis. 1985 May;151(5):775-82 [3886804] Can Med Assoc J. 1985 Jul 1;133(1):37-8 [3891061] Lancet. 1967 Nov 25;2(7526):1123-5 [4168560] J Biol Chem. 1973 Apr 10;248(7):2536-41 [4698230] J Biol Chem. 1980 Jan 10;255(1):284-9 [7350160] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] Infect Immun. 1985 Dec;50(3):695-700 [3905611] J Clin Microbiol. 1986 May;23(5):869-72 [3519658] Infect Immun. 1986 Jul;53(1):135-40 [3522426] J Infect Dis. 1986 Aug;154(2):338-41 [3522760] Infect Immun. 1987 Feb;55(2):455-61 [2879796] J Infect Dis. 1987 Mar;155(3):377-89 [3543152] J Infect Dis. 1987 Jul;156(1):175-82 [3298451] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] J Gen Microbiol. 1987 May;133(5):1309-17 [3655740] Infect Immun. 1987 Dec;55(12):3117-25 [3316033] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] Infect Immun. 1988 Aug;56(8):1926-33 [3294179] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] J Clin Microbiol. 1988 Jul;26(7):1292-7 [2842369] Microb Pathog. 1990 Jan;8(1):47-60 [2185397] Infect Immun. 1990 Aug;58(8):2438-45 [2196227] J Gen Microbiol. 1990 Jun;136(6):1125-35 [2200845] J Bacteriol. 1990 Nov;172(11):6386-95 [2228965] Proc Natl Acad Sci U S A. 1990 Oct;87(20):7839-43 [2172966] Infect Immun. 1990 Dec;58(12):3959-65 [2254023] Infect Immun. 1991 Mar;59(3):1065-73 [1997410] FEMS Microbiol Lett. 1991 Mar 15;63(1):27-30 [2044938] J Clin Microbiol. 1991 Jul;29(7):1339-43 [1679436] J Clin Microbiol. 1991 Dec;29(12):2704-9 [1757536] Mol Microbiol. 1991 Aug;5(8):1817-22 [1766367] J Clin Microbiol. 1991 Sep;29(9):1910-4 [1774316] Mol Microbiol. 1992 Feb;6(3):411-7 [1552854] Zentralbl Bakteriol. 1992 Jan;276(2):189-95 [1559007] J Infect Dis. 1992 May;165(5):979-80 [1569356] Microb Pathog. 1992 Apr;12(4):245-54 [1630295] Can J Microbiol. 1992 Jul;38(7):734-46 [1393838] Infect Immun. 1992 Oct;60(10):3953-61 [1398907] Appl Environ Microbiol. 1992 Dec;58(12):3809-15 [1476425] J Clin Microbiol. 1993 Feb;31(2):296-301 [8432815] Microb Pathog. 1992 Sep;13(3):225-36 [1291844] Infect Immun. 1993 Aug;61(8):3392-402 [8335369] J Clin Microbiol. 1988 Oct;26(10):2127-31 [3053764] Clin Microbiol Rev. 1989 Jan;2(1):15-38 [2644022] Adv Pediatr Infect Dis. 1989;4:51-81 [2645902] J Clin Microbiol. 1989 Jun;27(6):1180-6 [2666436] J Infect Dis. 1989 Sep;160(3):469-75 [2668430] Microb Pathog. 1989 May;6(5):381-90 [2671581] Infect Immun. 1990 Mar;58(3):611-8 [2155181] Lancet. 1983 Jul 23;2(8343):216 [6135046] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cross-shelf sediment transport by an anticyclonic eddy off Northern California AN - 50307955; 1993-038315 JF - Science AU - Washburn, Libe AU - Swenson, Mark S AU - Largier, John L AU - Korso, P Michael AU - Ramp, Steven R Y1 - 1993/09// PY - 1993 DA - September 1993 SP - 1560 EP - 1564 PB - American Association for the Advancement of Science, Washington, DC VL - 261 IS - 5128 SN - 0036-8075, 0036-8075 KW - United States KW - East Pacific KW - ocean circulation KW - imagery KW - Northeast Pacific KW - time series analysis KW - sediment transport KW - statistical analysis KW - sedimentation KW - suspended materials KW - marine transport KW - North American Pacific KW - California KW - North Pacific KW - eddies KW - Pacific Ocean KW - continental shelf KW - Northern California KW - color imagery KW - remote sensing KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50307955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=Cross-shelf+sediment+transport+by+an+anticyclonic+eddy+off+Northern+California&rft.au=Washburn%2C+Libe%3BSwenson%2C+Mark+S%3BLargier%2C+John+L%3BKorso%2C+P+Michael%3BRamp%2C+Steven+R&rft.aulast=Washburn&rft.aufirst=Libe&rft.date=1993-09-01&rft.volume=261&rft.issue=5128&rft.spage=1560&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 25 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch maps N1 - Last updated - 2012-06-07 N1 - CODEN - SCIEAS N1 - SubjectsTermNotLitGenreText - California; color imagery; continental shelf; East Pacific; eddies; imagery; marine transport; North American Pacific; North Pacific; Northeast Pacific; Northern California; ocean circulation; Pacific Ocean; remote sensing; sediment transport; sedimentation; statistical analysis; suspended materials; time series analysis; United States ER - TY - JOUR T1 - Dermorphin analog Tyr-D-Arg2-Phe-sarcosine-induced opioid analgesia and respiratory stimulation: the role of mu 1-receptors? AN - 75900381; 8394909 AB - Tyr-D-Arg2-Phe-sarcosine4 (TAPS), a mu-selective tetrapeptide analog of dermorphin, induced sustained antinociception and stimulated ventilatory minute volume (MV) at the doses of 3 to 100 pmol i.c.v. The doses of 30 and 100 pmol i.c.v. induced catalepsy. The effect of TAPS on MV was in negative correlation with the dose and the maximal response was achieved by the lowest (3 pmol) dose (+63 +/- 23%, P < .05). Morphine, an agonist at both mu 1 and mu 2 sites, at a dose of 150 nmol i.c.v. (equianalgesic to 100 pmol of TAPS decreased the MV by 30%, due to a decrease in ventilatory tidal volume. The antinociceptive effect of TAPS was antagonized by naloxone and the mu 1 receptor antagonist, naloxonazine. Naloxonazine also attenuated the catalepsy produced by 100 pmol of TAPS i.c.v. and the respiratory stimulation produced by 3 pmol of TAPS i.c.v. Pretreatment with 30 pmol of TAPS antagonized the respiratory depression induced by the mu opioid agonist dermorphin (changes in MV after dermorphin alone at 1 or 3 nmol were -22 +/- 10% and -60 +/- 9% and, after pretreatment with TAPS, +44 +/- 11% and -18 +/- 5%, respectively). After combined pretreatment with naloxonazine and TAPS, 1 nmol of dermorphin had no significant effect on ventilation. In contrast, pretreatment with a low respiratory stimulant dose (10 pmol i.c.v.) of dermorphin did not modify the effect of 1 nmol of dermorphin. In conclusion, the antinociceptive, cataleptic and respiratory stimulant effects of TAPS appear to be a related to its agonist action at the mu 1 opioid receptors.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Paakkari, P AU - Paakkari, I AU - Vonhof, S AU - Feuerstein, G AU - Sirén, A L AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1993/08// PY - 1993 DA - August 1993 SP - 544 EP - 550 VL - 266 IS - 2 SN - 0022-3565, 0022-3565 KW - Analgesics KW - 0 KW - Oligopeptides KW - Opioid Peptides KW - Receptors, Opioid, mu KW - dermorphin KW - 2SEC01B703 KW - Naloxone KW - 36B82AMQ7N KW - naloxonazine KW - 82824-01-9 KW - tyrosyl-arginyl-phenylalanyl-sarcosine KW - 90549-86-3 KW - Index Medicus KW - Rats KW - Naloxone -- pharmacology KW - Animals KW - Rats, Sprague-Dawley KW - Catalepsy -- chemically induced KW - Dose-Response Relationship, Drug KW - Naloxone -- analogs & derivatives KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Male KW - Receptors, Opioid, mu -- physiology KW - Respiration -- drug effects KW - Analgesics -- pharmacology KW - Receptors, Opioid, mu -- drug effects KW - Oligopeptides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75900381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Dermorphin+analog+Tyr-D-Arg2-Phe-sarcosine-induced+opioid+analgesia+and+respiratory+stimulation%3A+the+role+of+mu+1-receptors%3F&rft.au=Paakkari%2C+P%3BPaakkari%2C+I%3BVonhof%2C+S%3BFeuerstein%2C+G%3BSir%C3%A9n%2C+A+L&rft.aulast=Paakkari&rft.aufirst=P&rft.date=1993-08-01&rft.volume=266&rft.issue=2&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-09-17 N1 - Date created - 1993-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term ouabain administration produces hypertension in rats. AN - 75871166; 8340153 AB - Ouabain has recently been identified as an endogenous Na(+)-K+ pump inhibitor. We administered ouabain chronically to normotensive rats with varying degrees of reduced renal mass (RRM) and to normal two-kidney rats to see whether hypertension could be produced. Normal male Wistar rats and rats with 25%, 60%, and 70% RRM received ouabain (13.9 micrograms/kg per day IP) in normal saline for 4 weeks followed by ouabain (27.8 micrograms/kg per day IP) for 3 to 4 more weeks. Respective control animals received vehicle only. Blood pressure was recorded weekly by tail plethysmography. Animals received tap water and standard rat chow, except for 70% RRM rats, which received distilled water and sodium-free chow. After 6 to 8 weeks of treatment, with rats under thiobutabarbital anesthesia, direct blood pressure was determined. Plasma, tissue, and urinary ouabain levels were measured with a specific radioimmunoassay. Animals receiving ouabain developed significant increases in mean blood pressure compared with control animals (70% RRM, 147 +/- 4 vs 116 +/- 4 mm Hg; 60% RRM, 140 +/- 4 vs 107 +/- 3 mm Hg; 25% RRM, 131 +/- 5 vs 100 +/- 2 mm Hg; no RRM, 116 +/- 4 vs 98 +/- 5 mm Hg). Plasma ouabain levels measured 24 hours after the last ouabain dose were not different in animals receiving ouabain vs those receiving vehicle. However, kidney tissue ouabain levels were significantly greater (6.39 +/- 1.17 vs 2.36 +/- 0.52 micrograms/kg, P < .05) in animals receiving ouabain. In conclusion, ouabain, given chronically, is associated with the development of hypertension in RRM rats as well as in normal rats. Blood pressure was greater in animals with greater degrees of RRM for a given ouabain dose. JF - Hypertension (Dallas, Tex. : 1979) AU - Yuan, C M AU - Manunta, P AU - Hamlyn, J M AU - Chen, S AU - Bohen, E AU - Yeun, J AU - Haddy, F J AU - Pamnani, M B AD - Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Md. Y1 - 1993/08// PY - 1993 DA - August 1993 SP - 178 EP - 187 VL - 22 IS - 2 SN - 0194-911X, 0194-911X KW - Ouabain KW - 5ACL011P69 KW - Index Medicus KW - Rats KW - Injections, Intraperitoneal KW - Hemodynamics -- drug effects KW - Animals KW - Drug Administration Schedule KW - Nephrectomy KW - Dose-Response Relationship, Drug KW - Rats, Wistar KW - Blood Pressure -- drug effects KW - Time Factors KW - Male KW - Ouabain -- metabolism KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Ouabain -- pharmacology KW - Ouabain -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75871166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Long-term+ouabain+administration+produces+hypertension+in+rats.&rft.au=Yuan%2C+C+M%3BManunta%2C+P%3BHamlyn%2C+J+M%3BChen%2C+S%3BBohen%2C+E%3BYeun%2C+J%3BHaddy%2C+F+J%3BPamnani%2C+M+B&rft.aulast=Yuan&rft.aufirst=C&rft.date=1993-08-01&rft.volume=22&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=0194911X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-09-02 N1 - Date created - 1993-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of the relative toxicities of Shiga-like toxins type I and type II for mice. AN - 75833227; 8335369 AB - In earlier studies using a streptomycin-treated mouse model of infection caused by enterohemorrhagic Escherichia coli (EHEC), animals fed Shiga-like toxin type II (SLT-II)-producing strains developed acute renal cortical necrosis and died, while mice fed Shiga-like toxin type I (SLT-I)-producing clones did not die (E. A. Wadolkowski, L. M. Sung, J. A. Burris, J. E. Samuel, and A. D. O'Brien, Infect. Immun. 58:3959-3965, 1990). To examine the bases for the differences we noted between the two toxins in the murine infection model, we injected mice with purified toxins and carried out histopathological examinations. Despite the genetic and structural similarities between the two toxins, SLT-II had a 50% lethal dose (LD50) which was approximately 400 times lower than that of SLT-I when injected intravenously or intraperitoneally into mice. Histopathologic examination of toxin-injected mice revealed that detectable damage was limited to renal cortical tubule epithelial cells. Passive administration of anti-SLT-II antibodies protected mice from SLT-II-mediated kidney damage and death. Immunofluorescence staining of normal murine kidney sections incubated with purified SLT-I or SLT-II demonstrated that both toxins bound to cortical tubule and medullary duct epithelial cells. Compared with SLT-I, SLT-II was more heat and pH stable, suggesting that SLT-II is a relatively more stable macromolecule. Although both toxins bound to globotriaosylceramide, SLT-I bound with a higher affinity in a solid-phase binding assay. Differences in enzymatic activity between the two toxins were not detected. These data suggest that structural/functional differences between the two toxins, possibly involving holotoxin stability and/or receptor affinity, may contribute to the differential LD50s in mice. JF - Infection and immunity AU - Tesh, V L AU - Burris, J A AU - Owens, J W AU - Gordon, V M AU - Wadolkowski, E A AU - O'Brien, A D AU - Samuel, J E AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1993/08// PY - 1993 DA - August 1993 SP - 3392 EP - 3402 VL - 61 IS - 8 SN - 0019-9567, 0019-9567 KW - Antibodies, Monoclonal KW - 0 KW - Bacterial Toxins KW - Enterotoxins KW - Shiga Toxin 1 KW - Shiga Toxin 2 KW - Trihexosylceramides KW - globotriaosylceramide KW - 71965-57-6 KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - Kidney -- pathology KW - Hydrogen-Ion Concentration KW - Trihexosylceramides -- metabolism KW - Kidney -- drug effects KW - Mice KW - Antibodies, Monoclonal -- immunology KW - Hot Temperature KW - Lethal Dose 50 KW - Trihexosylceramides -- analysis KW - Male KW - Bacterial Toxins -- metabolism KW - Escherichia coli -- pathogenicity KW - Bacterial Toxins -- toxicity KW - Enterotoxins -- toxicity KW - Bacterial Toxins -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75833227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Comparison+of+the+relative+toxicities+of+Shiga-like+toxins+type+I+and+type+II+for+mice.&rft.au=Tesh%2C+V+L%3BBurris%2C+J+A%3BOwens%2C+J+W%3BGordon%2C+V+M%3BWadolkowski%2C+E+A%3BO%27Brien%2C+A+D%3BSamuel%2C+J+E&rft.aulast=Tesh&rft.aufirst=V&rft.date=1993-08-01&rft.volume=61&rft.issue=8&rft.spage=3392&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-26 N1 - Date created - 1993-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1988 Aug 15;42(2):185-94 [2456994] J Gen Microbiol. 1983 Oct;129(10):3121-37 [6418852] J Clin Microbiol. 1988 Oct;26(10):2127-31 [3053764] Microb Pathog. 1988 Feb;4(2):127-35 [3059137] J Biol Chem. 1989 Jan 5;264(1):596-601 [2642481] Clin Microbiol Rev. 1989 Jan;2(1):15-38 [2644022] Nephron. 1989;51(2):207-10 [2644572] Infect Immun. 1989 Dec;57(12):3743-50 [2807546] J Infect Dis. 1989 Dec;160(6):994-8 [2685131] Infect Immun. 1990 Mar;58(3):611-8 [2155181] J Infect Dis. 1990 May;161(5):961-5 [2324546] Microb Pathog. 1990 Jan;8(1):47-60 [2185397] Infect Immun. 1990 Aug;58(8):2438-45 [2196227] J Gen Microbiol. 1990 Jun;136(6):1125-35 [2200845] Arch Dis Child. 1990 Jul;65(7):722-7 [2201262] J Bacteriol. 1990 Nov;172(11):6386-95 [2228965] J Exp Med. 1984 Dec 1;160(6):1767-81 [6392471] Proc Natl Acad Sci U S A. 1985 Feb;82(4):1074-8 [3156376] Infect Immun. 1985 Dec;50(3):695-700 [3905611] J Exp Med. 1986 Jun 1;163(6):1391-404 [3519828] Infect Immun. 1986 Jul;53(1):135-40 [3522426] FEBS Lett. 1980 Aug 11;117(1):84-8 [6893307] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] J Biol Chem. 1981 Aug 25;256(16):8732-8 [7021550] Infect Immun. 1983 Dec;42(3):914-23 [6196297] J Infect Dis. 1987 Jun;155(6):1249-53 [3553350] J Biol Chem. 1987 Jun 25;262(18):8834-9 [3298243] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] Kidney Int. 1987 Aug;32(2):292-308 [3309432] Infect Immun. 1987 Nov;55(11):2675-80 [2822579] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] Epidemiol Infect. 1987 Dec;99(3):613-24 [3322851] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] Biochem Biophys Res Commun. 1988 Apr 29;152(2):674-9 [3284526] Infect Immun. 1988 Aug;56(8):1926-33 [3294179] Infect Immun. 1990 Dec;58(12):3959-65 [2254023] Microb Pathog. 1990 Aug;9(2):95-103 [2277589] J Biol Chem. 1991 Feb 25;266(6):3617-21 [1847382] Infect Immun. 1991 Mar;59(3):1065-73 [1997410] Int Immunol. 1990;2(1):1-8 [1965141] J Infect Dis. 1991 Aug;164(2):344-52 [1649877] Kidney Int. 1991 Aug;40(2):203-11 [1942768] Infect Immun. 1992 Feb;60(2):485-90 [1730480] Mol Microbiol. 1991 Aug;5(8):1817-22 [1766367] Nature. 1992 Feb 20;355(6362):748-50 [1741063] Infect Immun. 1992 Apr;60(4):1536-43 [1548077] Microb Pathog. 1992 Apr;12(4):245-54 [1630295] Br J Exp Pathol. 1955 Oct;36(5):439-46 [13269655] Br J Exp Pathol. 1955 Oct;36(5):447-53 [13269656] J Infect Dis. 1987 Mar;155(3):377-89 [3543152] Hum Pathol. 1988 Sep;19(9):1102-8 [3047052] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of diphtheria toxin repressor-operator interactions and characterization of a mutant repressor with decreased binding activity for divalent metals. AN - 75998589; 8412663 AB - The diphtheria toxin repressor (DtxR) is an Fe(2+)-activated protein with sequence-specific DNA-binding activity for the diphtheria toxin (tox) operator. Under high-iron conditions in Corynebacterium diphtheriae, DtxR represses toxin and siderophore biosynthesis as well as iron uptake. DtxR and a mutant repressor with His-47 substituted for Arg-47, designated DtxR-R47H, were purified and compared. Six different divalent cations (Cd2+, Co2+, Fe2+, Mn2+, Ni2+, and Zn2+) activated the sequence-specific DNA-binding activity of DtxR and enabled it to protect the tox operator from DNase I digestion, but Cu2+ failed to activate DtxR. Hydroxyl radical footprinting experiments indicated that DtxR binds symmetrically about the dyad axis of the tox operator. Methylation protection experiments demonstrated that DtxR binding alters the susceptibility to methylation of three G residues within the AT-rich tox operator. These findings suggest that two or more monomers of DtxR are involved in binding to the tox operator, with symmetrical DNA-protein interactions occurring at each end of the palindromic operator. In this regard, DtxR resembles several other well-characterized prokaryotic repressor proteins but differs dramatically from the Fe(2+)-activated ferric uptake repressor protein (Fur) of Escherichia coli. The concentration of Co2+ required to activate DtxR-R47H was at least 10-fold greater than that needed to activate DtxR, but the sequence-specific DNA binding of activated DtxR-R47H was indistinguishable from that of wild-type DtxR. The markedly deficient repressor activity of DtxR-R47H is consistent with a significant decrease in its binding activity for divalent cations. JF - Molecular microbiology AU - Schmitt, M P AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 173 EP - 181 VL - 9 IS - 1 SN - 0950-382X, 0950-382X KW - dtxR KW - tox KW - Bacterial Proteins KW - 0 KW - Cations KW - DNA, Bacterial KW - DNA-Binding Proteins KW - Diphtheria Toxin KW - DtxR protein, Corynebacterium diphtheriae KW - Repressor Proteins KW - ferric uptake regulating proteins, bacterial KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Base Sequence KW - Iron -- pharmacology KW - Repressor Proteins -- metabolism KW - Molecular Sequence Data KW - Gene Expression Regulation, Bacterial -- drug effects KW - Escherichia coli -- genetics KW - Diphtheria Toxin -- genetics KW - Species Specificity KW - Protein Binding KW - Methylation KW - Bacterial Proteins -- genetics KW - Operator Regions, Genetic KW - Corynebacterium diphtheriae -- metabolism KW - Bacterial Proteins -- metabolism KW - DNA-Binding Proteins -- genetics KW - Corynebacterium diphtheriae -- genetics KW - DNA, Bacterial -- metabolism KW - DNA-Binding Proteins -- metabolism KW - Cations -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75998589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Analysis+of+diphtheria+toxin+repressor-operator+interactions+and+characterization+of+a+mutant+repressor+with+decreased+binding+activity+for+divalent+metals.&rft.au=Schmitt%2C+M+P%3BHolmes%2C+R+K&rft.aulast=Schmitt&rft.aufirst=M&rft.date=1993-07-01&rft.volume=9&rft.issue=1&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-11-04 N1 - Date created - 1993-11-04 N1 - Date revised - 2017-01-13 N1 - Gene symbol - dtxR; tox N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cerulenin inhibits the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in brefeldin A-resistant cell lines. AN - 75767245; 8509400 AB - We have found that cerulenin, an antibiotic that inhibits de novo fatty acid and cholesterol biosynthesis and fatty acylation of proteins, strongly inhibited the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in a brefeldin A (BFA)-resistant mutant of Vero cells (BER-40). The protective effect of cerulenin against ricin was also observed in two other BFA-resistant cell lines, Madin-Darby canine kidney, and PtK1 cells. In contrast to BER-40 cells, no significant effect of cerulenin was observed in Vero cells. Cerulenin did not affect the binding of ricin to the cell-surface receptors, but reduced significantly the internalization of ricin in BER-40 cells; no effect of cerulenin on the binding or internalization of ricin was observed in Vero, PtK1, and Madin-Darby canine kidney cells. Endocytic uptake of fluid-phase markers such as horseradish peroxidase and lucifer yellow was inhibited by cerulenin in BER-40 cells, but the endocytosis of transferrin via the coated pit/coated vesicle pathway was slightly increased. Cerulenin inhibited the degradation and excretion of ricin in BER-40 cells, and this effect of cerulenin was not observed in Vero cells. Furthermore, cerulenin inhibited the bulk protein secretion in a dose-dependent manner, with BER-40 cells being more susceptible than Vero cells. These results suggest that in addition to its effect on endocytosis, cerulenin interferes with the intracellular trafficking or processing of toxin molecules, and the vesicle transport system in BER-40 cells appears to be cerulenin-sensitive. Since addition of fatty acids and cholesterol did not reverse the effects of cerulenin, the protective effect of cerulenin against protein toxins is not due to an inhibition of de novo fatty acids and cholesterol biosynthesis. JF - The Journal of biological chemistry AU - Oda, T AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1993/06/15/ PY - 1993 DA - 1993 Jun 15 SP - 12596 EP - 12602 VL - 268 IS - 17 SN - 0021-9258, 0021-9258 KW - Bacterial Toxins KW - 0 KW - Cyclopentanes KW - Diphtheria Toxin KW - Exotoxins KW - Lectins KW - Plant Lectins KW - Ribosome Inactivating Proteins, Type 2 KW - Toxins, Biological KW - Virulence Factors KW - Cerulenin KW - 17397-89-6 KW - Brefeldin A KW - 20350-15-6 KW - modeccin KW - 65988-88-7 KW - Ricin KW - 9009-86-3 KW - Ethyl Methanesulfonate KW - 9H154DI0UP KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Animals KW - Toxins, Biological -- toxicity KW - Ethyl Methanesulfonate -- pharmacology KW - Endocytosis -- drug effects KW - Drug Resistance KW - Vero Cells KW - Cell Death -- drug effects KW - Models, Biological KW - Cell Line KW - Mutagenesis KW - Exotoxins -- antagonists & inhibitors KW - Cerulenin -- pharmacology KW - Diphtheria Toxin -- toxicity KW - Diphtheria Toxin -- antagonists & inhibitors KW - Lectins -- antagonists & inhibitors KW - Ricin -- toxicity KW - Ricin -- antagonists & inhibitors KW - Cyclopentanes -- toxicity KW - Cyclopentanes -- antagonists & inhibitors KW - Exotoxins -- toxicity KW - Lectins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75767245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Cerulenin+inhibits+the+cytotoxicity+of+ricin%2C+modeccin%2C+Pseudomonas+toxin%2C+and+diphtheria+toxin+in+brefeldin+A-resistant+cell+lines.&rft.au=Oda%2C+T%3BWu%2C+H+C&rft.aulast=Oda&rft.aufirst=T&rft.date=1993-06-15&rft.volume=268&rft.issue=17&rft.spage=12596&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-13 N1 - Date created - 1993-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Implications of psychological research on stress and technological accidents. AN - 75859517; 8328731 AB - Psychological research on stress, disasters, and human-made technological accidents have important implications for policy, planning, and legal resolution of situations caused by environmental hazards. The incidence of technological accidents and catastrophes seems to have increased, and the biobehavioral sequelae of such accidents among victims have implications for mental and physical health as well as for intervention and prevention. In this article, research on the long-term effects of human-made disasters is discussed in the context of contributions that psychological research and theory can make in decisions regarding where potential hazards are located, how they are managed, and how accidents are handled. Unique psychophysiological processes associated with toxic accidents make these stressors more potent and likely to cause long-term uncertainty and chronic stress. JF - The American psychologist AU - Baum, A AU - Fleming, I AD - Department of Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 665 EP - 672 VL - 48 IS - 6 SN - 0003-066X, 0003-066X KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Humans KW - Public Policy KW - Public Opinion KW - Stress Disorders, Post-Traumatic -- psychology KW - Disasters KW - Accidents -- psychology KW - Technology KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75859517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+psychologist&rft.atitle=Implications+of+psychological+research+on+stress+and+technological+accidents.&rft.au=Baum%2C+A%3BFleming%2C+I&rft.aulast=Baum&rft.aufirst=A&rft.date=1993-06-01&rft.volume=48&rft.issue=6&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=The+American+psychologist&rft.issn=0003066X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-12 N1 - Date created - 1993-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The risks and benefits of withdrawing antiepileptic therapy. AN - 75838416; 8329145 JF - Drug safety AU - Scherokman, B AU - Jabbari, B AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 399 EP - 403 VL - 8 IS - 6 SN - 0114-5916, 0114-5916 KW - Anticonvulsants KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Child KW - Recurrence KW - Anticonvulsants -- adverse effects KW - Anticonvulsants -- administration & dosage KW - Epilepsy -- drug therapy KW - Anticonvulsants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75838416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=The+risks+and+benefits+of+withdrawing+antiepileptic+therapy.&rft.au=Scherokman%2C+B%3BJabbari%2C+B&rft.aulast=Scherokman&rft.aufirst=B&rft.date=1993-06-01&rft.volume=8&rft.issue=6&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-17 N1 - Date created - 1993-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of fluconazole on the steady-state pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine in humans. AN - 75787228; 8513654 AB - Terfenadine is rapidly and nearly completely biotransformed during a first pass to an active acid metabolite. Accumulation of unmetabolized terfenadine has been associated with altered cardiac repolarization. Drug-drug interactions resulting in the accumulation of terfenadine have been reported for ketoconazole and erythromycin. Six subjects were given the recommended dose of terfenadine (60 mg every 12 hours) for 7 days before initiation of oral fluconazole (200 mg once daily). The mean metabolite area under the concentration-time curve increased by 34% and the time to maximum concentration of the metabolite was delayed from 2.3 to 4 hours by concurrent fluconazole. Unmetabolized terfenadine was not present in any subject, and cardiac repolarization was not significantly changed from baseline during any phase of the study. We conclude that a pharmacokinetic interaction between terfenadine and fluconazole exists; however, the absence of accumulation of parent terfenadine in plasma suggests that a clinically significant interaction is unlikely. JF - Clinical pharmacology and therapeutics AU - Honig, P K AU - Worham, D C AU - Zamani, K AU - Mullin, J C AU - Conner, D P AU - Cantilena, L R AD - Division of Clinical Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 630 EP - 636 VL - 53 IS - 6 SN - 0009-9236, 0009-9236 KW - Terfenadine KW - 7BA5G9Y06Q KW - Fluconazole KW - 8VZV102JFY KW - Abridged Index Medicus KW - Index Medicus KW - Drug Interactions KW - Prospective Studies KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Electrocardiography -- drug effects KW - Terfenadine -- pharmacokinetics KW - Terfenadine -- blood KW - Fluconazole -- pharmacology KW - Terfenadine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75787228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=The+effect+of+fluconazole+on+the+steady-state+pharmacokinetics+and+electrocardiographic+pharmacodynamics+of+terfenadine+in+humans.&rft.au=Honig%2C+P+K%3BWorham%2C+D+C%3BZamani%2C+K%3BMullin%2C+J+C%3BConner%2C+D+P%3BCantilena%2C+L+R&rft.aulast=Honig&rft.aufirst=P&rft.date=1993-06-01&rft.volume=53&rft.issue=6&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-21 N1 - Date created - 1993-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification, sequencing, and targeted mutagenesis of a DNA polymerase gene required for the extreme radioresistance of Deinococcus radiodurans. AN - 75736584; 8501062 AB - Deinococcus radiodurans and other species of the same genus share extreme resistance to ionizing radiation and many other agents that damage DNA. Two different DNA damage-sensitive strains generated by chemical mutagenesis were found to be defective in a gene that has extended DNA and protein sequence homology with polA of Escherichia coli. Both mutant strains lacked DNA polymerase, as measured in activity gels. Transformation of this gene from wild-type D. radiodurans restored to the mutants both polymerase activity and DNA damage resistance. A technique for targeted insertional mutagenesis in D. radiodurans is presented. This technique was employed to construct a pol mutant isogenic with the wild type (the first example of targeted mutagenesis in this eubacterial family). This insertional mutant lacked DNA polymerase activity and was even more sensitive to DNA damage than the mutants derived by chemical mutagenesis. In the case of ionizing radiation, the survival of the wild type after receiving 1 Mrad was 100% while survival of the insertional mutant extrapolated to 10(-24). These results demonstrate that the gene described here encodes a DNA polymerase and that defects in this pol gene cause a dramatic loss of resistance of D. radiodurans to DNA damage. JF - Journal of bacteriology AU - Gutman, P D AU - Fuchs, P AU - Ouyang, L AU - Minton, K W AD - Department of Pathology, F. E. Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 3581 EP - 3590 VL - 175 IS - 11 SN - 0021-9193, 0021-9193 KW - polA KW - DNA Polymerase I KW - EC 2.7.7.- KW - Index Medicus KW - X-Rays KW - Ultraviolet Rays KW - Base Sequence KW - Gamma Rays KW - Transformation, Genetic KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Sequence Analysis, DNA KW - Mutagenesis, Insertional KW - Cloning, Molecular KW - DNA Polymerase I -- genetics KW - Gram-Positive Cocci -- radiation effects KW - Genes, Bacterial -- genetics KW - Gram-Positive Cocci -- genetics KW - Radiation Tolerance -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75736584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Identification%2C+sequencing%2C+and+targeted+mutagenesis+of+a+DNA+polymerase+gene+required+for+the+extreme+radioresistance+of+Deinococcus+radiodurans.&rft.au=Gutman%2C+P+D%3BFuchs%2C+P%3BOuyang%2C+L%3BMinton%2C+K+W&rft.aulast=Gutman&rft.aufirst=P&rft.date=1993-06-01&rft.volume=175&rft.issue=11&rft.spage=3581&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-01 N1 - Date created - 1993-07-01 N1 - Date revised - 2017-01-13 N1 - Gene symbol - polA N1 - SuppNotes - Cited By: Radiat Res. 1974 Feb;57(2):260-75 [10874941] Biochim Biophys Acta. 1978 Aug 23;520(1):122-30 [698224] J Gen Microbiol. 1967 Nov;49(2):293-300 [6077931] J Bacteriol. 1969 Feb;97(2):647-52 [5773016] Nature. 1969 Dec 20;224(5225):1166-8 [4902143] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Mutat Res. 1991 May;254(3):207-15 [1711150] Nucleic Acids Res. 1991 Aug 11;19(15):4127-32 [1651477] Int J Radiat Biol. 1991 Oct;60(4):613-26 [1680142] J Bacteriol. 1991 Oct;173(19):6110-7 [1655698] Plasmid. 1992 Nov;28(3):258-61 [1461940] Biochim Biophys Acta. 1964 Aug 12;87:664-8 [14220696] Genetics. 1979 Oct;93(2):321-43 [395024] Mol Gen Genet. 1980;179(1):191-9 [6935492] Gene. 1980 Nov;11(3-4):291-8 [6260575] J Biol Chem. 1982 Feb 25;257(4):1958-64 [6276402] J Bacteriol. 1983 Nov;156(2):576-83 [6313608] J Gen Microbiol. 1983 Aug;129(8):2437-45 [6415229] Anal Biochem. 1983 Dec;135(2):423-30 [6362484] Mutat Res. 1985 May;145(3):119-28 [3838572] Arch Microbiol. 1985 Feb;141(1):91-4 [2986569] Gene. 1985;33(3):305-11 [2989093] J Mol Biol. 1985 Nov 20;186(2):283-93 [3910840] Science. 1988 Apr 8;240(4849):199-201 [2832946] Mutat Res. 1988 Mar-Apr;207(3-4):117-9 [3357488] J Biol Chem. 1989 Apr 15;264(11):6427-37 [2649500] J Bacteriol. 1989 May;171(5):2480-4 [2651403] Plasmid. 1989 Sep;22(2):132-42 [2695951] J Bacteriol. 1990 Jun;172(6):2955-61 [2160933] Protein Eng. 1990 May;3(6):461-7 [2196557] EMBO J. 1991 Jan;10(1):17-24 [1989882] EMBO J. 1991 Jan;10(1):25-33 [1989886] Gene. 1991 Feb 1;98(1):45-52 [1849496] J Bacteriol. 1971 Mar;105(3):976-83 [4929286] Science. 1971 May 21;172(3985):851-4 [4929534] J Bacteriol. 1973 Apr;114(1):121-7 [4572706] J Bacteriol. 1975 Feb;121(2):422-8 [1112771] Bacteriol Rev. 1976 Mar;40(1):168-89 [1267736] Biochim Biophys Acta. 1977 Mar 2;475(1):23-31 [14686] J Mol Biol. 1977 Oct 15;116(1):81-98 [338918] J Bacteriol. 1978 Apr;134(1):71-5 [649572] Mol Gen Genet. 1978 Apr 17;160(3):331-7 [672894] J Mol Biol. 1966 May;17(1):237-54 [4289765] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of digitalis-like substance in the hypertension of streptozotocin-induced diabetes in reduced renal mass rats. AN - 75788835; 8390268 AB - We have previously reported that chronic hypertension develops consistently in Wistar rats with a 25% reduction in renal mass (RRM) following the induction of insulin dependent diabetes mellitus (IDDM) with streptozotocin (STZ, 65 mg/kg body weight, intravenously). In this study, we examined the role of the endogenous digitalis-like substance in the development of hypertension. Four groups of rats were studied: 1) 25% RRM rats with STZ-induced IDDM (25-DM), 2) normal rats with STZ-induced IDDM (2K-DM), 3) 25% RRM rats with vehicle treatment (25-V), and 4) normal rats with vehicle treatment (2K-V). In 25-DM rats, blood pressure progressively increased during the 3 weeks after STZ treatment and was associated with microalbuminuria, low plasma renin activity, and extracellular volume expansion. In contrast, the 2K-DM, 25-V, and 2K-V rats remained normotensive. Furthermore, the plasma and urine levels of digoxin-like immunoreactive factor (DIF), determined by digoxin radioimmunoassay (Baxter), were significantly higher in hypertensive 25-DM rats than in their controls. The same was the case for plasma digitalis-like substance (DLS), determined by exposing canine Na+,K(+)-ATPase to plasma fractions and observing the percent inhibition. Increased DIF and DLS in hypertensive 25-DM rats was associated with a significant decrease in Na+,K(+)-ATPase activity of microsomes prepared from the left and right ventricles, when compared with microsomes from normotensive 2K-DM animals. Microsomal 5'-nucleotidase, a plasma membrane marker, was unchanged. The DIF and DLS correlated significantly with each other and with myocardial Na+,K(+)-ATPase activity and mean blood pressure. These results suggest that increased endogenous digitalis-like substance, which inhibits cardiovascular muscle cell Na(+)-K(+)-pump activity, may be involved in the mechanism of hypertension associated with IDDM in 25% RRM rats. JF - American journal of hypertension AU - Chen, S AU - Yuan, C AU - Clough, D AU - Schooley, J AU - Haddy, F J AU - Pamnani, M B AD - Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 397 EP - 406 VL - 6 IS - 5 Pt 1 SN - 0895-7061, 0895-7061 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Index Medicus KW - Rats KW - Animals KW - Sodium-Potassium-Exchanging ATPase -- metabolism KW - Myocardium -- enzymology KW - Rats, Wistar KW - Microsomes -- enzymology KW - Radioimmunoassay KW - Urine -- chemistry KW - Male KW - Plants, Toxic KW - Digitalis KW - Hypertension -- physiopathology KW - Nephrectomy KW - Hypertension -- blood KW - Diabetic Angiopathies -- blood KW - Plants, Medicinal KW - Diabetic Angiopathies -- physiopathology KW - Hypertension -- etiology KW - Diabetes Mellitus, Experimental -- complications KW - Diabetic Angiopathies -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75788835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hypertension&rft.atitle=Role+of+digitalis-like+substance+in+the+hypertension+of+streptozotocin-induced+diabetes+in+reduced+renal+mass+rats.&rft.au=Chen%2C+S%3BYuan%2C+C%3BClough%2C+D%3BSchooley%2C+J%3BHaddy%2C+F+J%3BPamnani%2C+M+B&rft.aulast=Chen&rft.aufirst=S&rft.date=1993-05-01&rft.volume=6&rft.issue=5+Pt+1&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hypertension&rft.issn=08957061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-21 N1 - Date created - 1993-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of early gene expression in murine macrophages by synthetic lipid A analogs with differing endotoxic potentials. AN - 75692835; 7683001 AB - Numerous lipid A analogs have been synthesized in an attempt to dissociate endotoxic activities from beneficial immunomodulatory activities. In the present study, we have evaluated select lipid A analogs in macrophages for their ability to induce a panel of lipopolysaccharide (LPS)-inducible genes to gain insights into the molecular mechanisms which underlie endotoxicity. We evaluated three monosaccharide lipid A analogs: SDZ MRL 953, an agonist with an improved therapeutic margin over endotoxin; SDZ 281.288, a more toxic analog; and SDZ 880.431, an analog with proven LPS-inhibitory activity. In addition, three disaccharide lipid A analogs (i.e., lipid IVA, SDZ 880.611, and SDZ 880.924) that differ in acylation and phosphorylation patterns were also examined and compared with synthetic lipid A. With the exception of SDZ 880.431, each of these structurally diverse analogs was able to induce the complete panel of LPS-inducible genes, specifically genes which encode tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta, 75-kDa type 2 TNF receptor (D7), IP-10, D3, and D8. These results underscore that macrophage stimulation by lipid A analogs is permissive to considerable structural diversity. Structures with favorable therapeutic indices (SDZ MRL 953, SDZ 880.611, and SDZ 880.924) were not different from structures with poor therapeutic indices (lipid A, lipid IVA, and SDZ 281.288) with regard to gene induction. Nonetheless, the nontoxic SDZ MRL 953 was approximately 1,000-fold less potent than synthetic lipid A at inducing TNF-alpha secretion, and perhaps this contributes to the lack of toxicity exhibited by this compound. The ability of compound SDZ 880.431 to inhibit TNF-alpha secretion induced by both SDZ MRL 953 and smooth LPS suggests that the monosaccharide and smooth LPS share a receptor or a portion thereof. A pattern of protein tyrosine phosphorylation similar to that induced by LPS was stimulated by the monosaccharide SDZ MRL 953 and SDZ 281.288 and disaccharides lipid IVA, SDZ 880.924, and SDZ 880.611, providing evidence for a common signalling pathway. JF - Infection and immunity AU - Perera, P Y AU - Manthey, C L AU - Stütz, P L AU - Hildebrandt, J AU - Vogel, S N AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4788. Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 2015 EP - 2023 VL - 61 IS - 5 SN - 0019-9567, 0019-9567 KW - Endotoxins KW - 0 KW - Glycolipids KW - Interleukin-1 KW - Lipid A KW - Lipopolysaccharides KW - RNA, Messenger KW - Tumor Necrosis Factor-alpha KW - SDZ 880-431 KW - 101662-30-0 KW - SDZ MRL 953 KW - 123136-61-8 KW - SDZ 281-288 KW - 143060-83-7 KW - Phosphotyrosine KW - 21820-51-9 KW - Tyrosine KW - 42HK56048U KW - lipid X KW - 86559-73-1 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Index Medicus KW - Animals KW - Interleukin-1 -- pharmacology KW - Mice KW - Protein-Tyrosine Kinases -- metabolism KW - RNA, Messenger -- genetics KW - Tumor Necrosis Factor-alpha -- genetics KW - Structure-Activity Relationship KW - In Vitro Techniques KW - Carbohydrate Sequence KW - Mice, Inbred C3H KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives KW - Glycolipids -- pharmacology KW - Time Factors KW - Female KW - Gene Expression -- drug effects KW - Lipopolysaccharides -- pharmacology KW - Lipid A -- chemistry KW - Macrophages -- physiology KW - Lipid A -- pharmacology KW - Endotoxins -- pharmacology KW - Lipid A -- analogs & derivatives KW - Endotoxins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75692835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Induction+of+early+gene+expression+in+murine+macrophages+by+synthetic+lipid+A+analogs+with+differing+endotoxic+potentials.&rft.au=Perera%2C+P+Y%3BManthey%2C+C+L%3BSt%C3%BCtz%2C+P+L%3BHildebrandt%2C+J%3BVogel%2C+S+N&rft.aulast=Perera&rft.aufirst=P&rft.date=1993-05-01&rft.volume=61&rft.issue=5&rft.spage=2015&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-24 N1 - Date created - 1993-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1992 Jul;60(7):2694-701 [1535339] J Immunol. 1992 Jul 1;149(1):359-66 [1318905] Ann Intern Med. 1964 Mar;60:384-400 [14128219] Biochemistry. 1967 Aug;6(8):2363-72 [4867999] Biochemistry. 1979 Nov 27;18(24):5294-9 [518835] Proc Natl Acad Sci U S A. 1979 Nov;76(11):5939-43 [293694] Proc Natl Acad Sci U S A. 1983 Aug;80(15):4624-8 [6348772] Proc Natl Acad Sci U S A. 1985 Jan;82(2):282-6 [3881760] Infect Immun. 1985 Jul;49(1):225-37 [3891627] Infect Immun. 1985 Aug;49(2):286-90 [3894231] Proc Natl Acad Sci U S A. 1985 Sep;82(18):6060-4 [3898078] J Biochem. 1985 Aug;98(2):395-406 [4066647] Nucleic Acids Res. 1986 Mar 25;14(6):2829 [3754329] Infect Immun. 1986 Jun;52(3):905-7 [3519466] Infect Immun. 1986 Dec;54(3):673-82 [3781622] J Immunol. 1987 May 1;138(9):2935-40 [3106494] J Immunol. 1988 May 15;140(10):3640-5 [2452194] Infect Immun. 1989 Apr;57(4):1336-8 [2784418] J Immunol. 1989 Apr 1;142(7):2325-31 [2494257] Crit Rev Microbiol. 1989;16(6):477-523 [2663021] J Biol Chem. 1989 Oct 15;264(29):17182-9 [2477366] Pharm Res. 1990 Mar;7(3):260-3 [2160074] J Biol Chem. 1990 Jun 5;265(16):9159-64 [2345168] Biochem Biophys Res Commun. 1990 May 16;168(3):1261-7 [2189406] J Exp Med. 1990 Jul 1;172(1):77-84 [2193101] J Immunol. 1990 Nov 15;145(10):3333-9 [2172382] Proc Natl Acad Sci U S A. 1991 May 15;88(10):4148-52 [1709735] Antimicrob Agents Chemother. 1991 Mar;35(3):500-5 [2039200] Infect Immun. 1991 Jul;59(7):2351-8 [1646770] J Biol Chem. 1991 Oct 15;266(29):19490-8 [1918061] J Immunol. 1992 Oct 1;149(7):2459-65 [1356126] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of radiation therapy in management of pulmonary Kaposi's sarcoma. AN - 75636361; 7680826 AB - Although the incidence of AIDS-related Kaposi's sarcoma (KS) has been declining in recent years, the uncommon and unfortunate progression to symptomatic pulmonary KS still represents a significant therapeutic challenge. Pulmonary KS generally occurs in the late stages of the disease. Review of the literature and of the experience of the Walter Reed Army Medical Center Radiation Oncology Service suggests that early intervention with radiation therapy may provide palliation of the often distressing symptoms that herald KS-induced respiratory failure and may have a favorable impact on quality of life and survival time. JF - Southern medical journal AU - Doyle, M AU - Johnstone, P A AU - Watkins, E B AD - Uniformed Services University of the Health Sciences, Bethesda, Md. Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 285 EP - 288 VL - 86 IS - 3 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Respiratory Function Tests KW - Radiation Dosage KW - AIDS-Related Opportunistic Infections -- complications KW - Hospitals, Military KW - Humans KW - Retrospective Studies KW - Quality of Life KW - CD4-Positive T-Lymphocytes KW - Leukocyte Count KW - Survival Rate KW - Treatment Outcome KW - Incidence KW - Maryland -- epidemiology KW - Female KW - Male KW - Acquired Immunodeficiency Syndrome -- complications KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- radiotherapy KW - Lung Neoplasms -- epidemiology KW - Acquired Immunodeficiency Syndrome -- blood KW - Sarcoma, Kaposi -- epidemiology KW - Palliative Care -- standards KW - Palliative Care -- methods KW - Sarcoma, Kaposi -- radiotherapy KW - Sarcoma, Kaposi -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75636361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Role+of+radiation+therapy+in+management+of+pulmonary+Kaposi%27s+sarcoma.&rft.au=Doyle%2C+M%3BJohnstone%2C+P+A%3BWatkins%2C+E+B&rft.aulast=Doyle&rft.aufirst=M&rft.date=1993-03-01&rft.volume=86&rft.issue=3&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-15 N1 - Date created - 1993-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences. AN - 75616210; 8445813 AB - To examine prospectively the effects of ketoconazole on the pharmacokinetics and electrocardiographic repolarization pharmacodynamics (corrected QT intervals) of terfenadine in men and women. Prospective cohort study with each subject serving as his or her own control. Outpatient cardiology clinic and inpatient telemetry unit for monitoring period. Six healthy volunteers (four men and two women, aged 24 to 35 years) not taking any prescription or over-the-counter medications. After achieving a steady state while taking terfenadine (60 mg every 12 hours for 7 days), daily concomitant oral ketoconazole (200 mg every 12 hours) was added to the subjects' regimen. Pharmacokinetic profiles were obtained while subjects were taking terfenadine alone and after the addition of ketoconazole. Electrocardiograms were obtained at baseline, after 1 week of taking terfenadine alone, and at the time of the second pharmacokinetic profile after the addition of ketoconazole to the regimen. Terfenadine and its acid metabolite serum concentrations and corrected QT intervals. All subjects had detectable levels of unmetabolized terfenadine after the addition of ketoconazole, which was associated with QT prolongation. Only two of the six subjects could complete the entire course of ketoconazole coadministration. Four subjects received a shortened duration of ketoconazole therapy because of significant electrocardiographic repolarization abnormalities. There was a significant change in the area under the curve of the acid metabolite of terfenadine after the addition of ketoconazole administration. Ketoconazole alters the metabolism of terfenadine in normal men and women and results in the accumulation of unmetabolized parent drug, which is associated with significant prolongation of the corrected QT interval. This drug combination should be avoided. JF - JAMA AU - Honig, P K AU - Wortham, D C AU - Zamani, K AU - Conner, D P AU - Mullin, J C AU - Cantilena, L R AD - Division of Clinical Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Md. 20814-4799. PY - 1993 SP - 1513 EP - 1518 VL - 269 IS - 12 SN - 0098-7484, 0098-7484 KW - Terfenadine KW - 7BA5G9Y06Q KW - Ketoconazole KW - R9400W927I KW - Abridged Index Medicus KW - Index Medicus KW - Drug Interactions KW - Prospective Studies KW - Humans KW - Adult KW - Male KW - Female KW - Electrocardiography -- drug effects KW - Terfenadine -- pharmacology KW - Terfenadine -- pharmacokinetics KW - Heart -- drug effects KW - Ketoconazole -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75616210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Terfenadine-ketoconazole+interaction.+Pharmacokinetic+and+electrocardiographic+consequences.&rft.au=Honig%2C+P+K%3BWortham%2C+D+C%3BZamani%2C+K%3BConner%2C+D+P%3BMullin%2C+J+C%3BCantilena%2C+L+R&rft.aulast=Honig&rft.aufirst=P&rft.date=1993-03-01&rft.volume=269&rft.issue=12&rft.spage=1513&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-05 N1 - Date created - 1993-04-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 1993 Mar 24-31;269(12):1550-2 [8445821] Erratum In: JAMA 1993 Apr 28;269(16):2088 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Computerized task battery assessment of cognitive and performance effects of acute phenytoin motion sickness therapy. AN - 75614803; 8447800 AB - Phenytoin was previously evaluated as an efficacious anti-motion sickness therapy in more than 24 individuals. To be effective, this short-term, novel therapy requires serum levels in the anticonvulsant range; therefore, it became imperative that the effects of phenytoin upon cognition and performance be quantified. Each subject was tested on a performance battery (Criterion Task Set) on two occasions while on either phenytoin treatment or placebo for subsequent statistical comparison. We evaluated 23 subjects with phenytoin serum levels ranging from 8.9 to 23.9 micrograms/L. While subjects with the higher serum levels consistently reported subjective side effects, there was no statistically significant degradation of sensory, cognitive, or performance capabilities compared to placebo. JF - Aviation, space, and environmental medicine AU - Chelen, W AU - Ahmed, N AU - Kabrisky, M AU - Rogers, S AD - Air Force Institute of Technology and Aerospace Medical Research Laboratory, Wright-Patterson AFB, Dayton, OH. Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 201 EP - 205 VL - 64 IS - 3 Pt 1 SN - 0095-6562, 0095-6562 KW - Phenytoin KW - 6158TKW0C5 KW - Index Medicus KW - Space life sciences KW - Double-Blind Method KW - Humans KW - Adult KW - Male KW - Psychomotor Performance -- drug effects KW - Motion Sickness -- drug therapy KW - Cognition -- drug effects KW - Phenytoin -- therapeutic use KW - Phenytoin -- blood KW - Phenytoin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75614803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+space%2C+and+environmental+medicine&rft.atitle=Computerized+task+battery+assessment+of+cognitive+and+performance+effects+of+acute+phenytoin+motion+sickness+therapy.&rft.au=Chelen%2C+W%3BAhmed%2C+N%3BKabrisky%2C+M%3BRogers%2C+S&rft.aulast=Chelen&rft.aufirst=W&rft.date=1993-03-01&rft.volume=64&rft.issue=3+Pt+1&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+space%2C+and+environmental+medicine&rft.issn=00956562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-07 N1 - Date created - 1993-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Laryngeal reconstruction following vertical partial laryngectomy. AN - 85194636; pmid-8426502 AB - Laryngeal reconstruction following vertical partial laryngectomy (VPL) with arytenoidectomy was studied in 30 dogs. Variations of a superiorly based thyroid cartilage flap (TCF) were used for reconstruction. In addition, sternohyoid muscle reconstruction and endolaryngeal muscle coverage were studied. Larynges were recovered after a 6-month period in 28 surviving dogs and were analyzed by endoscopic photographs and axial whole-organ sections. Endoscopic assessment (n = 18) demonstrated good results for arytenoid replacement (100%), pseudocord position (94%), pseudocord development (94%), and airway patency (100%). Arytenoid replacement was judged as completely (78%) or partially (22%) replaced. This was accomplished by a pseudocord extending to the cricoid in the horizontal plane. Pseudocord position was judged as normal (83%) or paramedian (11%), with the remainder lateralized (6%). Pseudocord development was judged as complete (72%) or partial (22%), with the remainder poor (6%). Reviewing both endoscopic photographs and gross sections (n = 28), airways were all normal without laryngeal or tracheal stenosis. Histologic assessment (n = 24) also demonstrated good results for arytenoid replacement (79%), pseudocord position (87%), and TCF survival in the glottic plane (79%). Arytenoid replacement was judged as complete (62%) or partial (17%), with the remainder poor (21%). Pseudocord position was judged as normal (50%) or paramedian (37%), with the remainder lateralized (13%). TCF survival was judged as total (63%) or partial (16%). Although not present in the glottic plane in the remaining cases (21%), a portion of the TCF was always present in the supraglottic region. The TCF was largely replaced by bone in the region of the pseudocord, and was covered by nonkeratinizing stratified squamous epithelium and a thick fibrous layer. Breakdown over the TCF was infrequent, with a small focus of granulation tissue over cartilage present in 1 (4%) of 24 cases. Clinically insignificant granulation tissue was present in a total of 6 (25%) cases. In the other 5 cases, this was over muscle or over permanent sutures. Focal cartilage necrosis was present in 2 (8%) of 24 cases, and was localized, self limiting, and deep to the endolaryngeal surface. When the TCF failed to survive histologically, poorer results for arytenoid replacement and pseudocord position generally resulted. However, this apparent difference was not statistically significant due to small sample sizes and variability in results. Other factors that may have kept this difference from becoming larger were thought to be contraction of th e normal cord towards the operated side with fore-shortening of the glottis, and medial rotation and ossification of the posterior thyroid ala remnant.(ABSTRACT TRUNCATED AT 400 WORDS) JF - The Laryngoscope AU - Burgess, L P AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Md. PY - 1993 SP - 109 EP - 132 VL - 103 IS - 2 SN - 0023-852X, 0023-852X KW - Thyroid Cartilage KW - Neck Muscles KW - Graft Survival KW - Laryngectomy KW - Animal KW - Dogs KW - Larynx KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Laryngoscopy KW - Surgical Flaps UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85194636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Laryngeal+reconstruction+following+vertical+partial+laryngectomy.&rft.au=Burgess%2C+L+P&rft.aulast=Burgess&rft.aufirst=L&rft.date=1993-02-01&rft.volume=103&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Involvement of the Golgi region in the intracellular trafficking of cholera toxin. AN - 75568937; 8425904 AB - The intracellular pathway following receptor-mediated endocytosis of cholera toxin was studied using brefeldin A (BFA), which inhibited protein secretion and induced dramatic morphological changes in the Golgi region. In both mouse Y1 adrenal cells and CHO cells, BFA at 1 micrograms/ml caused a 80-90% inhibition of the cholera toxin (CT)-induced elevation of intracellular cAMP. The inhibition of the cytotoxicity of CT by BFA was also observed in a rounding assay of Y1 adrenal cells. The inhibition of CT cytotoxicity by BFA was dose dependent, with the ID50 value similar to the LD50 of BFA in Y1 adrenal cells. Binding and internalization of [125I]-labeled cholera toxin in Y1 adrenal cells was not affected by BFA. Unlike the BFA-sensitive cell lines such as Y1 adrenal and CHO cells, BFA at 1 micrograms/ml did not inhibit the cytotoxicity of CT in PtK1 cells, of which the Golgi structure was BFA-resistant. These results strongly suggest that a BFA-sensitive Golgi is required for the protection of CT cytotoxicity by BFA. In contrast, elevation of the intracellular cAMP by forskolin, which acts directly on the plasma membrane adenylate cyclase, was not affected by BFA. These observations indicate that the intoxication of target cells by CT requires an intact Golgi region for its intracellular trafficking and/or processing. In this respect, CT shares a common intracellular pathway with ricin, Pseudomonas toxin, and modeccin, even though their structures and modes of action are very different. JF - Journal of cellular physiology AU - Nambiar, M P AU - Oda, T AU - Chen, C AU - Kuwazuru, Y AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 222 EP - 228 VL - 154 IS - 2 SN - 0021-9541, 0021-9541 KW - Cyclopentanes KW - 0 KW - Brefeldin A KW - 20350-15-6 KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Kinetics KW - Dipodomys KW - Mice KW - Cell Line KW - Cyclopentanes -- pharmacology KW - Golgi Apparatus -- ultrastructure KW - Golgi Apparatus -- drug effects KW - Cholera Toxin -- antagonists & inhibitors KW - Cholera Toxin -- toxicity KW - Golgi Apparatus -- metabolism KW - Cholera Toxin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75568937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Involvement+of+the+Golgi+region+in+the+intracellular+trafficking+of+cholera+toxin.&rft.au=Nambiar%2C+M+P%3BOda%2C+T%3BChen%2C+C%3BKuwazuru%2C+Y%3BWu%2C+H+C&rft.aulast=Nambiar&rft.aufirst=M&rft.date=1993-02-01&rft.volume=154&rft.issue=2&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-01 N1 - Date created - 1993-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of ouabain-like factors in hypertension: effects of ouabain and certain endogenous ouabain-like factors in hypertension. AN - 76215341; 7508010 AB - Several reports suggest the presence of sodium-potassium pump inhibitor in plasma and various tissues, particularly during volume-expanded state and low-renin hypertension. It has been hypothesized that by inhibiting the cardiovascular muscle-cell Na(+)-K+ pump, this inhibitor can constrict blood vessels, enhance vasoconstriction, and increase cardiac contractility, thereby raising blood pressure. Only two such endogenous inhibitors have been chemically characterized: the bufodienolide derivative, resibufogenin, obtained from toad skin and plasma; and a factor with the same structure (based on mass spectral analysis) as ouabain, from human plasma. However, unlike bufalin (aglycone), which is almost structurally identical to resibufogenin, neither ouabain nor ouabagenin (aglycone of ouabain) caused a sustained increase in blood pressure when infused in equimolar doses during a 30-min period in rats. Because the rat is 10(4)-fold less sensitive to ouabain than the human is, we wondered whether the absence of a response to ouabain was due to the short infusion time. Therefore, in new experiments ouabain was administered chronically during a 6- to 7-week period to two-kidney normal rats and rats with 70, 60, and 25% reduced renal mass. Reduced renal mass rats were used because these rats have decreased sodium excretion capacity, and thus we hoped the action of exogenous ouabain would be potentiated in these volume-expanded rats.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of cardiovascular pharmacology AU - Yuan, C AU - Manunta, P AU - Chen, S AU - Hamlyn, J M AU - Haddy, F J AU - Pamnani, M B AD - Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1993 PY - 1993 DA - 1993 SP - S10 EP - S12 VL - 22 Suppl 2 SN - 0160-2446, 0160-2446 KW - Ouabain KW - 5ACL011P69 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Index Medicus KW - Rats KW - Injections, Intraperitoneal KW - Animals KW - Kidney -- metabolism KW - Diet, Sodium-Restricted KW - Rats, Wistar KW - Kidney -- drug effects KW - Enzyme-Linked Immunosorbent Assay KW - Vasoconstriction -- drug effects KW - Cardiac Output -- drug effects KW - Radioimmunoassay KW - Male KW - Sodium-Potassium-Exchanging ATPase -- antagonists & inhibitors KW - Ouabain -- metabolism KW - Hypertension -- chemically induced KW - Ouabain -- blood KW - Blood Pressure -- drug effects KW - Ouabain -- pharmacology KW - Ouabain -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76215341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology&rft.atitle=Role+of+ouabain-like+factors+in+hypertension%3A+effects+of+ouabain+and+certain+endogenous+ouabain-like+factors+in+hypertension.&rft.au=Yuan%2C+C%3BManunta%2C+P%3BChen%2C+S%3BHamlyn%2C+J+M%3BHaddy%2C+F+J%3BPamnani%2C+M+B&rft.aulast=Yuan&rft.aufirst=C&rft.date=1993-01-01&rft.volume=22+Suppl+2&rft.issue=&rft.spage=S10&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology&rft.issn=01602446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-10 N1 - Date created - 1994-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of concomitant administration of cimetidine and ranitidine on the pharmacokinetics and electrocardiographic effects of terfenadine. AN - 75985497; 8405028 AB - Terfenadine is a widely prescribed non-sedating antihistamine which undergoes rapid and almost complete first pass biotransformation to an active carboxylic acid metabolite. It is unusual to find unmetabolised terfenadine in the plasma of patients taking the drug. Terfenadine in vitro is a potent blocker of the myocardial potassium channel. Overdose, hepatic compromise and the coadministration of ketoconazole and erythromycin result in the accumulation of terfenadine, which is thought to be responsible of QT prolongation and Torsades de Pointes ventricular arrhythmia in susceptible individuals. Cimetidine and ranitidine are two popular H2 antagonists which are often taken with terfenadine. The effects of cimetidine and ranitidine on terfenadine metabolism were studied in two cohorts of 6 normal volunteers given the recommended dose of terfenadine (60 mg every 12 h) for 1 week prior to initiation of cimetidine 600 mg every 12 h or ranitidine 150 mg every 12 h. Pharmacokinetic profiles and morning pre-dose electrocardiograms were obtained whilst the patients were on terfenadine alone and after the addition of cimetidine or rantidine. One of the subjects in each cohort had a detectable plasma level of parent compound after 1 week of terfenadine therapy alone; it did not accumulate further after addition of the H2 antagonist. The pharmacokinetics of the carboxylic acid metabolite of terfenadine (Cmax, tmax, AUC) were not significantly changed after co-administration of either H2 antagonist. None of the remaining 5 subjects in either cohort demonstrated accumulation of unmetabolised terfenadine after addition of the respective H2 antagonist and electrocardiographic QT intervals and T-U morphology in them was not changed during the course of the study.(ABSTRACT TRUNCATED AT 250 WORDS) JF - European journal of clinical pharmacology AU - Honig, P K AU - Wortham, D C AU - Zamani, K AU - Conner, D P AU - Mullin, J C AU - Cantilena, L R AD - Division of Clinical Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1993 PY - 1993 DA - 1993 SP - 41 EP - 46 VL - 45 IS - 1 SN - 0031-6970, 0031-6970 KW - Terfenadine KW - 7BA5G9Y06Q KW - Cimetidine KW - 80061L1WGD KW - Ranitidine KW - 884KT10YB7 KW - Index Medicus KW - Drug Interactions KW - Drug Administration Schedule KW - Prospective Studies KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Ranitidine -- pharmacology KW - Ranitidine -- administration & dosage KW - Terfenadine -- antagonists & inhibitors KW - Terfenadine -- pharmacokinetics KW - Cimetidine -- administration & dosage KW - Cimetidine -- pharmacology KW - Electrocardiography -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75985497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+clinical+pharmacology&rft.atitle=Effect+of+concomitant+administration+of+cimetidine+and+ranitidine+on+the+pharmacokinetics+and+electrocardiographic+effects+of+terfenadine.&rft.au=Honig%2C+P+K%3BWortham%2C+D+C%3BZamani%2C+K%3BConner%2C+D+P%3BMullin%2C+J+C%3BCantilena%2C+L+R&rft.aulast=Honig&rft.aufirst=P&rft.date=1993-01-01&rft.volume=45&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=European+journal+of+clinical+pharmacology&rft.issn=00316970&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-11-04 N1 - Date created - 1993-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of substrate supplementation with hydroxycholesterol analogues and serum lipoproteins on ovine luteal cell progesterone secretion in vitro: demonstration of prostaglandin F2 alpha luteolytic actions in a defined model system. AN - 75664765; 8464026 AB - In an attempt to establish a defined model system for studies aimed at elucidating the mechanism of PGF2 alpha action, we examined the effects of medium supplementation with soluble hydroxycholesterol analogues, alone and in combination with ovine luteinizing hormone (oLH) in the presence and absence of PGF2 alpha, on progesterone secretion by mixed ovine luteal cells in vitro. In short-term cultures (2-6 h), supplementary 22R-hydroxycholesterol (22R-OHC; 0.16-20 micrograms ml-1) increased (P < 0.05) progesterone production in a dose-dependent manner, whereas similar concentrations of 22S-hydroxycholesterol (22S-OHC) and 25-hydroxycholesterol (25-OHC) had little effect. In incubations of < or = 24 h duration, 22R-OHC (1 micrograms ml-1) dramatically increased progesterone secretion, whereas oLH (100 ng ml-1) in the presence or absence of PGF2 alpha (250 ng ml-1) had no consistent effects, alone or in combination with 22R-OHC. In contrast, 22R-OHC (1 micrograms ml-1) alone had no effect in long-term incubations (72-192 h), nor did treatment with oLH (100 ng ml-1) in the presence or absence of PGF2 alpha (250 ng ml-1) in the absence of 22R-OHC. Together, however, 22R-OHC and oLH stimulated (P < 0.05) progesterone secretion, a synergistic effect consistently inhibited (P < 0.05) by PGF2 alpha. Equimolar (2.5 mumol l-1) concentrations of 22R-OHC and homologous serum low- or high-density lipoprotein cholesterol exhibited comparable capacities to maintain progesterone secretion in long-term cultures (24-168 h), with and without gonadotrophin (oLH or human chorionic gonadotrophin, 100 ng ml-1) stimulation.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of reproduction and fertility AU - Fitz, T A AU - Contois, D F AU - Marr, M M AU - Rexroad, C E AU - Fritz, M A AD - Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 57 EP - 63 VL - 97 IS - 1 SN - 0022-4251, 0022-4251 KW - Culture Media KW - 0 KW - Hydroxycholesterols KW - Lipoproteins KW - 22-hydroxycholesterol KW - 17711-16-9 KW - Progesterone KW - 4G7DS2Q64Y KW - Luteinizing Hormone KW - 9002-67-9 KW - Dinoprost KW - B7IN85G1HY KW - Index Medicus KW - Stimulation, Chemical KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Sheep KW - Luteinizing Hormone -- pharmacology KW - Drug Synergism KW - Time Factors KW - Models, Biological KW - Female KW - Culture Media -- metabolism KW - Corpus Luteum -- cytology KW - Lipoproteins -- pharmacology KW - Hydroxycholesterols -- pharmacology KW - Dinoprost -- metabolism KW - Corpus Luteum -- metabolism KW - Progesterone -- biosynthesis KW - Luteolysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75664765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+reproduction+and+fertility&rft.atitle=Effects+of+substrate+supplementation+with+hydroxycholesterol+analogues+and+serum+lipoproteins+on+ovine+luteal+cell+progesterone+secretion+in+vitro%3A+demonstration+of+prostaglandin+F2+alpha+luteolytic+actions+in+a+defined+model+system.&rft.au=Fitz%2C+T+A%3BContois%2C+D+F%3BMarr%2C+M+M%3BRexroad%2C+C+E%3BFritz%2C+M+A&rft.aulast=Fitz&rft.aufirst=T&rft.date=1993-01-01&rft.volume=97&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+reproduction+and+fertility&rft.issn=00224251&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-03 N1 - Date created - 1993-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Successful treatment of an episode of malignant hyperthermia using a large dose of dantrolene. AN - 75611094; 8442973 AB - This clinical case report describes the use of extremely high doses of dantrolene in the management of an episode of malignant hyperthermia (MH). A 6-year-old, 25 kg girl underwent anesthetic induction with halothane for an elective inguinal herniorrhaphy. Tachydysrhythmias, laryngospasm, opisthotonos, rhabdomyolysis, and profound metabolic acidosis ensued as features of an MH crisis. Initial dantrolene administration did not alleviate the symptoms. Increasing doses of dantrolene eventually totaling 42 mg/kg, along with symptomatic supportive care, were administered successfully to treat the event. It is postulated that the severe muscle rigidity may have precluded the circulation of dantrolene to its site of action. The role of the Malignant Hyperthermia Association of the United States (MHAUS) Hotline as a 24-hour consultative service is noted. JF - Journal of clinical anesthesia AU - Blank, J W AU - Boggs, S D AD - Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD. PY - 1993 SP - 69 EP - 72 VL - 5 IS - 1 SN - 0952-8180, 0952-8180 KW - Isoflurane KW - CYS9AKD70P KW - Dantrolene KW - F64QU97QCR KW - Halothane KW - UQT9G45D1P KW - Index Medicus KW - Humans KW - Rhabdomyolysis -- chemically induced KW - Halothane -- adverse effects KW - Child KW - Rhabdomyolysis -- drug therapy KW - Anesthesia, Inhalation -- adverse effects KW - Myoglobinuria -- chemically induced KW - Isoflurane -- adverse effects KW - Myoglobinuria -- drug therapy KW - Masseter Muscle -- drug effects KW - Muscle Rigidity -- drug therapy KW - Female KW - Muscle Rigidity -- chemically induced KW - Malignant Hyperthermia -- drug therapy KW - Dantrolene -- administration & dosage KW - Dantrolene -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75611094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+anesthesia&rft.atitle=Successful+treatment+of+an+episode+of+malignant+hyperthermia+using+a+large+dose+of+dantrolene.&rft.au=Blank%2C+J+W%3BBoggs%2C+S+D&rft.aulast=Blank&rft.aufirst=J&rft.date=1993-01-01&rft.volume=5&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+anesthesia&rft.issn=09528180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-06 N1 - Date created - 1993-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Farallones moored array data report AN - 50365805; 1993-008823 JF - Open-File Report - U. S. Geological Survey AU - Kinoshita, Kaye L AU - Noble, Marlene A AU - Ramp, Steven R Y1 - 1993 PY - 1993 DA - 1993 SP - 108 PB - U. S. Geological Survey, Reston, VA SN - 0196-1497, 0196-1497 KW - United States KW - East Pacific KW - continental slope KW - Northeast Pacific KW - site exploration KW - Central California KW - sedimentation KW - suspended materials KW - marine transport KW - dredged materials KW - North American Pacific KW - California KW - San Francisco Bay region KW - Gulf of the Farallones KW - North Pacific KW - Pacific Ocean KW - continental shelf KW - waste disposal KW - USGS KW - 22:Environmental geology KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50365805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open-File+Report+-+U.+S.+Geological+Survey&rft.atitle=The+Farallones+moored+array+data+report&rft.au=Kinoshita%2C+Kaye+L%3BNoble%2C+Marlene+A%3BRamp%2C+Steven+R&rft.aulast=Kinoshita&rft.aufirst=Kaye&rft.date=1993-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Open-File+Report+-+U.+S.+Geological+Survey&rft.issn=01961497&rft_id=info:doi/ L2 - http://walrus.wr.usgs.gov/reports/ofr93-11/ https://pubs.er.usgs.gov/browse/usgs-publications/OFR LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 3 N1 - Availability - U. S. Geol. Surv., Denver, CO, United States N1 - PubXState - VA N1 - Document feature - illus. incl. 13 tables, sketch maps N1 - Last updated - 2016-09-16 N1 - CODEN - XGROAG N1 - SubjectsTermNotLitGenreText - California; Central California; continental shelf; continental slope; dredged materials; East Pacific; Gulf of the Farallones; marine transport; North American Pacific; North Pacific; Northeast Pacific; Pacific Ocean; San Francisco Bay region; sedimentation; site exploration; suspended materials; United States; USGS; waste disposal ER - TY - JOUR T1 - Apparent changes in the abundance and distribution of Anopheles species on Grenada Island AN - 16857127; 3568378 AB - Results of a recent survey of the 3 species of Anopheles mosquitoes, Anopheles (Nyssorhynchus) aquasalis, Anopheles (Nyssorhynchus) argyritarsis, and Anopheles (Anopheles) pseudopunctipennis, on the island of Grenada are contrasted with the only other published survey of these species on Grenada, which was published in 1938. Results suggest that a significant change in the abundance and distribution of each species has occurred over this period. Physical characteristics of the aquatic habitats for each species are described and compared. JF - Journal of the American Mosquito Control Association AU - Manguin, S AU - Peyton, EL AU - James, A C AU - Roberts AD - Dep. Prev. Med. and Biom., USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA Y1 - 1993 PY - 1993 DA - 1993 SP - 403 EP - 407 VL - 9 IS - 4 SN - 8756-971X, 8756-971X KW - Lesser Antilles, Grenada I. KW - West Indies, Grenada KW - aquatic insects KW - population changes KW - population number KW - ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts; Entomology Abstracts KW - geographical distribution KW - Culicidae KW - Freshwater KW - Anopheles aquasalis KW - habitat KW - Anopheles argyritarsis KW - surveys KW - Anopheles pseudopunctipennis KW - Diptera KW - abundance KW - Z 05230:Neotropical region KW - D 04659:Insects KW - Q1 08442:Population dynamics KW - Q1 08301:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16857127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Mosquito+Control+Association&rft.atitle=Apparent+changes+in+the+abundance+and+distribution+of+Anopheles+species+on+Grenada+Island&rft.au=Manguin%2C+S%3BPeyton%2C+EL%3BJames%2C+A+C%3BRoberts&rft.aulast=Manguin&rft.aufirst=S&rft.date=1993-01-01&rft.volume=9&rft.issue=4&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Mosquito+Control+Association&rft.issn=8756971X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - population number; habitat; geographical distribution; surveys; aquatic insects; abundance; population changes; Anopheles argyritarsis; Culicidae; Diptera; Anopheles pseudopunctipennis; Anopheles aquasalis; Freshwater ER - TY - JOUR T1 - Comparison of wind and wave forcing of longshore currents AN - 13674610; S199649697 AB - A simple model was used to integrate wave and wind forcing terms in the alongshore momentum equation across the surf zone. Waves were assumed to be generated by local winds and fully arisen, and the finite-depth TMA spectral wave energy spectrum (developed from TEXEL, MARSEN and ARSLOE sub-data sets) were used to describe wave force in terms of radiation stress. Results for different wind and wave conditions showed that wind force was proportional to surf zone width and inversely proportional to beach slope. Wind force increased more rapidly than wave force with increasing wind speed or increasing wind and wave incident angle and was considered negligible for obliquely onshore winds and steep beach slope (tan beta 0.10). For obliquely onshore winds and gentle beach slope (tan beta 0.01) wind force could be significant with wind to wave ratios of 10-100 per cent for winds of 10-30 m per second and wave directions of 10-80 degrees. Wind force could be a first-order term in the longshore momentum balance and for offshore winds longshore currents were totally wind driven. JF - Continental Shelf Research AU - Whitford, D J AU - Thornton, E B AD - Naval Postgraduate School, Monterey, Calif. Y1 - 1993 PY - 1993 DA - 1993 SP - 1205 EP - 1218 VL - 13 IS - 11 SN - 0278-4343, 0278-4343 KW - Modelling (-general-) KW - Steepness KW - Surf KW - Wind KW - Aqualine Abstracts KW - AQ 00001:Water Resources and Supplies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13674610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Continental+Shelf+Research&rft.atitle=Comparison+of+wind+and+wave+forcing+of+longshore+currents&rft.au=Whitford%2C+D+J%3BThornton%2C+E+B&rft.aulast=Whitford&rft.aufirst=D&rft.date=1993-01-01&rft.volume=13&rft.issue=11&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=Continental+Shelf+Research&rft.issn=02784343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Theoretical. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Ultraviolet-induced dimerization of non-adjacent pyrimidines in poly[d(A-T)]. AN - 73391620; 1460000 AB - The DNA photoproduct responsible for the ultraviolet (UV) light-induced -1 frameshift mutation remains unknown. We recently identified a UV photoproduct consisting of a cyclobutane dimer occurring between non-adjacent thymine residues in the same strand, [sequence: see text] and proposed that replication across this unrepaired photoproduct might result in a -1 frameshift mutation since the intervening base is extrahelical. Until now this novel photoproduct has only been identified in single-stranded DNA polymers and does not occur in UV-irradiated double-stranded polymers due to conformational restraint. This observation suggested that this photoproduct could only occur in vivo in chromosomal sites that were single-stranded. In the current work the cis-syn dithymine cyclobutane dimer has been identified in the self-complementary polymer poly[d(A-T)] when UV irradiated in solution conditions (concentrated manganese chloride or 60% ethanol plus trace salts) wherein this polymer remains double-stranded but the double-helix is partially destabilized. Taken together, the current findings suggest that dipyrimidine photoproducts between non-adjacent residues on the same strand could occur in vivo in double-stranded, but partially destabilized, DNA. JF - The Journal of biological chemistry AU - Love, J D AU - Minton, K W AD - Department of Pathology, F. E. Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1992/12/15/ PY - 1992 DA - 1992 Dec 15 SP - 24953 EP - 24959 VL - 267 IS - 35 SN - 0021-9258, 0021-9258 KW - Pyrimidine Dimers KW - 0 KW - Pyrimidines KW - Poly dA-dT KW - 26966-61-0 KW - Index Medicus KW - Base Sequence KW - Isomerism KW - Electrophoresis, Agar Gel KW - Dose-Response Relationship, Radiation KW - Frameshift Mutation KW - Ultraviolet Rays KW - DNA Damage KW - Poly dA-dT -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73391620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Ultraviolet-induced+dimerization+of+non-adjacent+pyrimidines+in+poly%5Bd%28A-T%29%5D.&rft.au=Love%2C+J+D%3BMinton%2C+K+W&rft.aulast=Love&rft.aufirst=J&rft.date=1992-12-15&rft.volume=267&rft.issue=35&rft.spage=24953&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-12 N1 - Date created - 1993-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of stimulated tissue factor expression by brain microvascular endothelial cells from normotensive (WKY) and hypertensive (SHR) rats. AN - 73405005; 1473006 AB - The amounts of tissue factor (TF) expressed by brain microvascular endothelial cells (BMECs) from normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were compared after stimulating the cells with different doses of lipopolysaccharide (LPS), thrombin, phorbol myristic acid (PMA), Ca(2+)-ionophore (A23187), or tumor necrosis factor (TNF) and interleukin-1 (IL-1). Treatment of cultured BMECs from WKY and SHR with all of these factors dose-dependently increased their total amount of TF; no substantive differences in the levels of enhanced TF expression were observed between WKY and SHR BMECs. We conclude that stimulated endothelium from rats with hypertension, a major stroke risk factor, is not hyperresponsive with respect to TF expression when compared to normotensive controls. JF - Brain research AU - Doron, D A AU - McCarron, R M AU - Heldman, E AU - Sirén, A L AU - Spatz, M AU - Feuerstein, G AU - Pollard, H B AU - Hallenbeck, J M AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1992/12/04/ PY - 1992 DA - 1992 Dec 04 SP - 346 EP - 349 VL - 597 IS - 2 SN - 0006-8993, 0006-8993 KW - Interleukin-1 KW - 0 KW - Lipopolysaccharides KW - Tumor Necrosis Factor-alpha KW - Calcimycin KW - 37H9VM9WZL KW - Thromboplastin KW - 9035-58-9 KW - Thrombin KW - EC 3.4.21.5 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Rats KW - Animals KW - Interleukin-1 -- pharmacology KW - Rats, Inbred WKY KW - Rats, Inbred SHR KW - Thrombin -- pharmacology KW - Microcirculation -- drug effects KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Lipopolysaccharides -- toxicity KW - Calcimycin -- pharmacology KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Brain -- drug effects KW - Brain -- blood supply KW - Brain -- metabolism KW - Thromboplastin -- biosynthesis KW - Hypertension -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73405005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Comparison+of+stimulated+tissue+factor+expression+by+brain+microvascular+endothelial+cells+from+normotensive+%28WKY%29+and+hypertensive+%28SHR%29+rats.&rft.au=Doron%2C+D+A%3BMcCarron%2C+R+M%3BHeldman%2C+E%3BSir%C3%A9n%2C+A+L%3BSpatz%2C+M%3BFeuerstein%2C+G%3BPollard%2C+H+B%3BHallenbeck%2C+J+M&rft.aulast=Doron&rft.aufirst=D&rft.date=1992-12-04&rft.volume=597&rft.issue=2&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-03 N1 - Date created - 1993-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Isolation and characterization of a brefeldin A-resistant mutant of monkey kidney Vero cells. AN - 73395497; 1459197 AB - Brefeldin A (BFA) is a fungal antibiotic which disrupts protein transport between the endoplasmic reticulum and the Golgi. A BFA-resistant mutant of monkey kidney Vero cells, BER-40, which exhibited about a 90-fold increase in the LD50 of BFA (5.2 ng/ml for Vero cells versus 460 ng/ml for BER-40 cells), has been isolated. The increased resistance of BER-40 cells toward BFA was also manifested in a greatly reduced inhibition of protein secretion by BFA in the mutant and a lack of protection by BFA of the mutant cells from ricin cytotoxicity. Somatic cell hybridization between the Vero and BER-40 cells showed that the BFA-resistance in BER-40 behaved as a codominant trait. The structure of the Golgi region, as examined by immunofluorescence microscopy with antibodies against Golgi markers (the 110-kDa protein and mannosidase II) or with fluorescent lipid NBD-ceramide, was unchanged in the mutant cells as compared to that in the wild-type cells. Treatment of Vero cells with BFA (1 micrograms/ml) or with 2-deoxyglucose plus sodium azide resulted in a rapid release of the 110-kDa protein, mannosidase II, and NBD-ceramide from the Golgi membrane to a more diffuse distribution in the cytosol. In contrast, these three Golgi markers remained to be Golgi-associated following treatment of BER-40 cells with BFA or with 2-deoxyglucose plus sodium azide. Immunoblotting of cell extracts from Vero and BER-40 cells with monoclonal antibody against the 110-kDa protein did not reveal any significant difference in the level of this Golgi marker in the mutant cells. These data suggest that the BFA-resistance mutation in BER-40 has rendered the cyclic pathway of the 110-kDa protein assembly to the Golgi membrane resistant to both BFA and 2-deoxyglucose plus sodium azide. JF - Experimental cell research AU - Chen, C H AU - Kuwazuru, Y AU - Yoshida, T AU - Nambiar, M AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 321 EP - 328 VL - 203 IS - 2 SN - 0014-4827, 0014-4827 KW - Antifungal Agents KW - 0 KW - Azides KW - Cyclopentanes KW - Proteins KW - Brefeldin A KW - 20350-15-6 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Ricin KW - 9009-86-3 KW - Sodium Azide KW - 968JJ8C9DV KW - Deoxyglucose KW - 9G2MP84A8W KW - Mannosidases KW - EC 3.2.1.- KW - mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidase KW - EC 3.2.1.114 KW - Index Medicus KW - Animals KW - Ricin -- toxicity KW - Genes, Dominant KW - Adenosine Triphosphate -- metabolism KW - Azides -- pharmacology KW - Drug Resistance KW - Mannosidases -- metabolism KW - Deoxyglucose -- pharmacology KW - Mutation KW - Proteins -- secretion KW - Cyclopentanes -- pharmacology KW - Antifungal Agents -- pharmacology KW - Vero Cells -- metabolism KW - Vero Cells -- drug effects KW - Golgi Apparatus -- drug effects KW - Proteins -- metabolism KW - Golgi Apparatus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73395497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Isolation+and+characterization+of+a+brefeldin+A-resistant+mutant+of+monkey+kidney+Vero+cells.&rft.au=Chen%2C+C+H%3BKuwazuru%2C+Y%3BYoshida%2C+T%3BNambiar%2C+M%3BWu%2C+H+C&rft.aulast=Chen&rft.aufirst=C&rft.date=1992-12-01&rft.volume=203&rft.issue=2&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-12 N1 - Date created - 1993-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human glucocorticoid receptor gene deletion following exposure to cancer chemotherapeutic drugs and chemical mutagens. AN - 73308857; 1384968 AB - The sensitivity of the human glucocorticoid receptor (hGR) gene to mutagenesis by the cancer chemotherapeutic drugs adriamycin, bleomycin, and chlorambucil was evaluated using glucocorticoid-sensitive (dexs) subclones of the human leukemic cell line CEM-C7. Treatment of cells with either bleomycin or chlorambucil increased the frequency of glucocorticoid-resistant (dexr) clones 3.3- and 10-fold, respectively. Measurement of steroid-binding activity in intact dexr cells demonstrated that the predominant phenotype of drug-induced dexr clones was receptorless (r-). dexs CEM cells express only one functional hGR allele and, in addition, are heterozygous for a BclI restriction fragment length polymorphism in the hGR gene (L. A. Palmer and J. M. Harmon, Cancer Res., 51:5224-5231, 1991). To determine the basis of the r- phenotype, BclI digests of genomic DNA isolated from r+ and r- cell lines were examined for the presence of the polymorphic 2.4- and 4.4-kilobase digestion products. A deletion of all or part of the hGR gene was demonstrated by the absence of the 4.4-kilobase fragment in one of two bleomycin-induced dexr clones, as well as the ICR191-induced dexr cell line ICR27TK.3. Cytogenetic analysis of ICR27TK.3 showed that the distal portion of the long arm of one chromosome 5 had been replaced with a portion of chromosome 15. Thus, in at least two dexr cell lines, deletions and/or chromosome breaks in the hGR locus appear to account for the r- phenotype. JF - Cancer research AU - Palmer, L A AU - Hukku, B AU - Harmon, J M AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1992/12/01/ PY - 1992 DA - 1992 Dec 01 SP - 6612 EP - 6618 VL - 52 IS - 23 SN - 0008-5472, 0008-5472 KW - RNA, Messenger KW - 0 KW - Receptors, Glucocorticoid KW - Bleomycin KW - 11056-06-7 KW - Chlorambucil KW - 18D0SL7309 KW - Dexamethasone KW - 7S5I7G3JQL KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Phenotype KW - Karyotyping KW - Dexamethasone -- metabolism KW - Cells, Cultured KW - Humans KW - Bleomycin -- pharmacology KW - Receptors, Glucocorticoid -- drug effects KW - Alleles KW - Doxorubicin -- pharmacology KW - RNA, Messenger -- analysis KW - Chlorambucil -- pharmacology KW - Receptors, Glucocorticoid -- metabolism KW - Receptors, Glucocorticoid -- genetics KW - Gene Deletion KW - Chromosomes, Human, Pair 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73308857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Human+glucocorticoid+receptor+gene+deletion+following+exposure+to+cancer+chemotherapeutic+drugs+and+chemical+mutagens.&rft.au=Palmer%2C+L+A%3BHukku%2C+B%3BHarmon%2C+J+M&rft.aulast=Palmer&rft.aufirst=L&rft.date=1992-12-01&rft.volume=52&rft.issue=23&rft.spage=6612&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-16 N1 - Date created - 1992-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Muslim-Christian Encounters: Perceptions and Misperceptions AN - 61302714; 93a89766 JF - Review of Religious Research AU - Robinson, Glenn AU - Robinson, Glenn AD - Naval Postgraduate School Y1 - 1992/12// PY - 1992 DA - December 1992 SP - 189 EP - 190 VL - 34 IS - 2 SN - 0034-673X, 0034-673X KW - article KW - 1535: sociology of religion; sociology of religion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61302714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Review+of+Religious+Research&rft.atitle=Muslim-Christian+Encounters%3A+Perceptions+and+Misperceptions&rft.au=Robinson%2C+Glenn%3BWatt%2C+William+Montgomery&rft.aulast=Robinson&rft.aufirst=Glenn&rft.date=1992-12-01&rft.volume=34&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Review+of+Religious+Research&rft.issn=0034673X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - SuppNotes - Edition date: 1991. N1 - Last updated - 2016-09-28 N1 - CODEN - RVRRAU ER - TY - JOUR T1 - A psychophysical task to quantify smoking cessation-induced irritability: the reactive irritability scale (RIS). AN - 73443217; 1488939 AB - A psychophysical rating scale using magnitude estimation was developed as a tool to quantify irritability as one index of drug withdrawal. The scale measures reactive irritability by using environmental sounds as probes. Three studies are described in which target and reference stimuli are selected, tested for reliability, and presented to cigarette smokers abstaining from smoking, cigarette smokers who are not abstaining, and nonsmokers. This reactive irritability scale (RIS) was found to have test/re-test reliability and content validity. The RIS significantly differentiated abstaining smokers from nonsmokers and from smokers allowed to smoke, whereas the commonly used self-report measures of irritability failed to distinguish the two groups of smokers. By measuring irritability as a type of reactivity rather than as a static attribute, a different type of irritability is measured than that which is assessed by self-report questionnaires. The RIS should be used in the study of withdrawal from nicotine and other drugs of abuse. JF - Addictive behaviors AU - Acri, J B AU - Grunberg, N E AD - Department of Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. PY - 1992 SP - 587 EP - 601 VL - 17 IS - 6 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Environment KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Depressive Disorder -- diagnosis KW - Personality Inventory KW - Acoustic Stimulation KW - Hearing KW - Research Design KW - Male KW - Female KW - Irritable Mood KW - Smoking Cessation KW - Noise UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73443217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=A+psychophysical+task+to+quantify+smoking+cessation-induced+irritability%3A+the+reactive+irritability+scale+%28RIS%29.&rft.au=Acri%2C+J+B%3BGrunberg%2C+N+E&rft.aulast=Acri&rft.aufirst=J&rft.date=1992-11-01&rft.volume=17&rft.issue=6&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-25 N1 - Date created - 1993-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The varicella-zoster virus immediate early protein, IE62, can positively regulate its cognate promoter. AN - 73262356; 1329324 AB - Varicella-Zoster virus (VZV) is a neurotropic alphaherpes virus closely related to herpes simplex virus (HSV). However, unlike its close relative HSV, VZV lacks a functional alpha-TIF (alpha-gene transinducing factor) that activates the transcription of immediate early genes during the initial events of the virus life cycle. Hence, in the absence of a functional alpha-TIF, the mechanism triggering the expression of immediate early genes in VZV at present remains unclear. Accumulating evidence indicates that the gene product of the putative immediate early gene ORF62 (IE62) plays a pivotal role in activating VZV genes of all three putative kinetic classes, namely immediate early (alpha), early (beta), and late (gamma) classes of VZV genes. In the present study, we show that IE62 can positively autoregulate its cognate promoter using a transient transfection assay, both in lymphocytes and in neural cells. In the same system, we can also demonstrate activation of the VZV IE62 promoter by HSV ICP4. By deletion analysis and oligonucleotide-directed site-specific mutagenesis we have localized specific regions in the IE62 promoter/upstream sequences that mediate inducibility by IE62 and HSV ICP4, and provide evidence that this promoter activation by these two proteins may be through different mechanisms. These data, taken together with the recent demonstration of the presence of IE62 in the VZ virion tegument (Kinchington, P.R., Hoagland, J.K., Arvin, A.M., Ruyechan, W.T., and Hay, J. 1992. J. Virol. 66, 359-366) provides a possible mechanism by which the triggering of VZV gene expression occurs in the absence of a functional alpha-TIF protein. JF - Virology AU - Perera, L P AU - Mosca, J D AU - Sadeghi-Zadeh, M AU - Ruyechan, W T AU - Hay, J AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 346 EP - 354 VL - 191 IS - 1 SN - 0042-6822, 0042-6822 KW - DNA, Viral KW - 0 KW - IE62 protein, Human herpesvirus 3 KW - Immediate-Early Proteins KW - Trans-Activators KW - Viral Envelope Proteins KW - Viral Regulatory and Accessory Proteins KW - herpes simplex virus, type 1 protein ICP4 KW - Index Medicus KW - Animals KW - Base Sequence KW - Vero Cells -- microbiology KW - Neurons -- microbiology KW - T-Lymphocytes -- microbiology KW - Humans KW - Simplexvirus -- genetics KW - Molecular Sequence Data KW - Viral Regulatory and Accessory Proteins -- metabolism KW - Simplexvirus -- metabolism KW - Cell Line KW - Viral Regulatory and Accessory Proteins -- genetics KW - Promoter Regions, Genetic KW - Gene Expression Regulation, Viral KW - Viral Envelope Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73262356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=The+varicella-zoster+virus+immediate+early+protein%2C+IE62%2C+can+positively+regulate+its+cognate+promoter.&rft.au=Perera%2C+L+P%3BMosca%2C+J+D%3BSadeghi-Zadeh%2C+M%3BRuyechan%2C+W+T%3BHay%2C+J&rft.aulast=Perera&rft.aufirst=L&rft.date=1992-11-01&rft.volume=191&rft.issue=1&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-16 N1 - Date created - 1992-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras. AN - 73236241; 1399002 AB - Cholera enterotoxin (CT) is produced by Vibrio cholerae and excreted into the culture medium as an extracellular protein. CT consists of one A polypeptide and five B polypeptides associated by noncovalent bonds, and CT-B interacts with CT-A primarily via the A2 domain. Treatment of CT with trypsin cleaves CT-A into A1 and A2 fragments that are linked by a disulfide bond. CT-B binds to ganglioside GM1, which functions as the plasma membrane receptor for CT, and the enzymatic activity of A1 causes the toxic effects of CT on target cells. We constructed translational fusions that joined foreign proteins via their carboxyl termini to the A2 domain of CT-A, and we studied the interactions of the fusion proteins with CT-B. The A2 domain was necessary and sufficient to enable bacterial alkaline phosphatase (BAP), maltose-binding protein (MBP) or beta-lactamase (BLA) to associate with CT-B to form stable, immunoreactive, holotoxin-like chimeras. Each holotoxin-like chimera was able to bind to ganglioside GM1. Holotoxin-like chimeras containing the BAP-A2 and BLA-A2 fusion proteins had BAP activity and BLA activity, respectively. We constructed BAP-A2 mutants with altered carboxyl-terminal sequences and tested their ability to assemble into holotoxin-like chimeras. Although the carboxyl-terminal QDEL sequence of the BAP-A2 fusion protein was not required for interaction with CT-B, most BAP-A2 mutants with altered carboxyl termini did not form holotoxin-like chimeras. When holotoxin-like chimeras containing BAP-A2, MBP-A2, or BLA-A2 were synthesized in V. cholerae, they were found predominantly in the periplasm. The toxin secretory apparatus of V. cholerae was not able, therefore, to translocate these holotoxin-like chimeras across the outer membrane. JF - Infection and immunity AU - Jobling, M G AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 4915 EP - 4924 VL - 60 IS - 11 SN - 0019-9567, 0019-9567 KW - ctxB KW - Macromolecular Substances KW - 0 KW - Oligonucleotides KW - Recombinant Fusion Proteins KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Base Sequence KW - Oligonucleotides -- chemistry KW - Molecular Sequence Data KW - Biological Transport KW - Amino Acid Sequence KW - Mutation KW - Structure-Activity Relationship KW - Cloning, Molecular KW - Cholera Toxin -- immunology KW - Recombinant Fusion Proteins -- immunology KW - Cholera Toxin -- chemistry KW - Recombinant Fusion Proteins -- chemistry KW - Cholera Toxin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73236241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Fusion+proteins+containing+the+A2+domain+of+cholera+toxin+assemble+with+B+polypeptides+of+cholera+toxin+to+form+immunoreactive+and+functional+holotoxin-like+chimeras.&rft.au=Jobling%2C+M+G%3BHolmes%2C+R+K&rft.aulast=Jobling&rft.aufirst=M&rft.date=1992-11-01&rft.volume=60&rft.issue=11&rft.spage=4915&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-25 N1 - Date created - 1992-11-25 N1 - Date revised - 2017-01-24 N1 - Gene symbol - ctxB N1 - SuppNotes - Cited By: Nature. 1992 Feb 6;355(6360):561-4 [1741035] Science. 1983 Jul 15;221(4607):289-91 [6857285] Mol Microbiol. 1991 Jul;5(7):1755-67 [1943708] Nucleic Acids Res. 1990 Feb 25;18(4):1069 [2179864] FEMS Microbiol Lett. 1990 Mar 1;56(1-2):149-54 [2332153] Arch Biochem Biophys. 1985 Jun;239(2):549-55 [2408574] Biochemistry. 1989 Feb 7;28(3):1333-40 [2713368] Proc Natl Acad Sci U S A. 1985 Dec;82(23):8129-33 [2999794] Trends Biochem Sci. 1988 Jul;13(7):265-9 [3076724] Gene. 1987;56(2-3):309-12 [3315864] Nature. 1984 Apr 12-18;308(5960):655-8 [6324005] Proc Natl Acad Sci U S A. 1984 Dec;81(24):7752-6 [6393126] Science. 1991 Jul 26;253(5018):382-3 [1862340] J Clin Invest. 1991 May;87(5):1780-6 [1902492] Gene. 1991 Apr;100:189-94 [1905257] Gene. 1991 Mar 15;99(2):255-9 [2022336] Nature. 1991 May 30;351(6325):371-7 [2034287] J Biol Chem. 1990 Jan 15;265(2):1225-30 [2295609] Nucleic Acids Res. 1990 Sep 11;18(17):5315-6 [2402474] FEBS Lett. 1986 Nov 24;208(2):194-8 [2430831] Rev Infect Dis. 1987 May-Jun;9(3):544-61 [2440089] Gene. 1988 Apr 29;64(2):265-75 [2841198] Proc Natl Acad Sci U S A. 1988 Oct;85(19):7109-13 [3050987] FEBS Lett. 1988 Dec 5;241(1-2):110-4 [3058509] Infect Immun. 1988 Jul;56(7):1748-53 [3290106] J Biol Chem. 1967 Apr 10;242(7):1604-11 [5337047] DNA. 1984;3(2):173-82 [6327214] J Mol Biol. 1983 Jun 5;166(4):557-80 [6345791] Erratum In: Infect Immun. 1993 Mar;61(3):1168 [8094381] N1 - Last updated - 2017-01-25 ER - TY - JOUR T1 - Rhodopseudomonas sphaeroides lipid A derivatives block in vitro induction of tumor necrosis factor and endotoxin tolerance by smooth lipopolysaccharide and monophosphoryl lipid A. AN - 73234465; 1398939 AB - Rhodopseudomonas (Rhodobacter) sphaeroides diphosphoryl lipid A is a relatively inert species of lipid A but has been shown to antagonize the effects of toxic lipopolysaccharide (LPS) both in vivo and in vitro. The antagonist and its monophosphoryl derivative were examined for the ability to block tumor necrosis factor synthesis and reverse tolerance induction in vitro in macrophage cultures stimulated with bioactive preparations of smooth LPS, rough LPS, diphosphoryl lipid A, and monophosphoryl lipid A. Inhibition of agonist activity and reversal of tolerance by these novel penta-acylated lipid A antagonists provides new insight into macrophage-LPS interactions. JF - Infection and immunity AU - Henricson, B E AU - Perera, P Y AU - Qureshi, N AU - Takayama, K AU - Vogel, S N AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1992/10// PY - 1992 DA - October 1992 SP - 4285 EP - 4290 VL - 60 IS - 10 SN - 0019-9567, 0019-9567 KW - Lipid A KW - 0 KW - Lipopolysaccharides KW - Tumor Necrosis Factor-alpha KW - diphosphoryl lipid A KW - monophosphoryl lipid A KW - MWC0ET1L2P KW - Index Medicus KW - Animals KW - Mice, Inbred C3H KW - Mice KW - Macrophages -- drug effects KW - Structure-Activity Relationship KW - Lipid A -- toxicity KW - Rhodopseudomonas -- chemistry KW - Lipopolysaccharides -- toxicity KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Lipid A -- pharmacology KW - Lipid A -- analogs & derivatives KW - Rhodopseudomonas -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73234465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Rhodopseudomonas+sphaeroides+lipid+A+derivatives+block+in+vitro+induction+of+tumor+necrosis+factor+and+endotoxin+tolerance+by+smooth+lipopolysaccharide+and+monophosphoryl+lipid+A.&rft.au=Henricson%2C+B+E%3BPerera%2C+P+Y%3BQureshi%2C+N%3BTakayama%2C+K%3BVogel%2C+S+N&rft.aulast=Henricson&rft.aufirst=B&rft.date=1992-10-01&rft.volume=60&rft.issue=10&rft.spage=4285&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-26 N1 - Date created - 1992-10-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1990 Aug;58(8):2429-37 [1695201] J Clin Invest. 1942 Sep;21(5):589-99 [16694949] FASEB J. 1991 Sep;5(12):2652-60 [1916089] J Biol Chem. 1991 Oct 15;266(29):19490-8 [1918061] Infect Immun. 1991 Jan;59(1):441-4 [1987057] J Biol Chem. 1991 Apr 5;266(10):6532-8 [2007601] J Biol Chem. 1989 Dec 25;264(36):21951-6 [2480960] Crit Rev Microbiol. 1989;16(6):477-523 [2663021] Infect Immun. 1989 Apr;57(4):1336-8 [2784418] J Biol Chem. 1988 Aug 25;263(24):11971-6 [3136169] J Immunol. 1988 Dec 15;141(12):4196-202 [3143760] J Biol Chem. 1988 Apr 25;263(12):5502-4 [3258599] Prog Clin Biol Res. 1988;272:17-45 [3293075] Eur J Biochem. 1987 Nov 16;169(1):27-31 [3315662] Infect Immun. 1986 Apr;52(1):6-11 [3514464] Prog Clin Biol Res. 1987;231:25-53 [3588622] J Immunol. 1985 Dec;135(6):3763-71 [3905964] Biochemistry. 1967 Aug;6(8):2363-72 [4867999] Eur J Biochem. 1972 Jul 13;28(2):166-73 [5069711] Eur J Biochem. 1969 Jun;9(2):245-9 [5804498] J Biol Chem. 1983 Nov 10;258(21):12947-51 [6355099] Infect Immun. 1984 Aug;45(2):350-5 [6378795] J Bacteriol. 1983 Jul;155(1):153-8 [6602801] Eur J Biochem. 1983 Oct 17;136(1):195-200 [6604629] J Biol Response Mod. 1984;3(1):1-9 [6707694] J Biol Chem. 1982 Oct 10;257(19):11808-15 [6749846] Scand J Infect Dis Suppl. 1982;31:8-21 [7048515] J Exp Med. 1965 Jun 1;121:911-33 [14319407] Infect Immun. 1991 Jan;59(1):131-6 [1898897] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cross-shore transport during DELILAH AN - 52839641; 1996-045532 JF - Eos, Transactions, American Geophysical Union AU - Humiston, R AU - Thornton, E AU - Anonymous Y1 - 1992/10// PY - 1992 DA - October 1992 SP - 255 PB - American Geophysical Union, Washington, DC VL - 73 IS - 43, Suppl. SN - 0096-3941, 0096-3941 KW - bedload KW - ocean circulation KW - experimental studies KW - DELILAH KW - sediment transport KW - suspended materials KW - nearshore environment KW - marine transport KW - tides KW - beaches KW - velocity KW - bathymetry KW - ocean floors KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52839641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Cross-shore+transport+during+DELILAH&rft.au=Humiston%2C+R%3BThornton%2C+E%3BAnonymous&rft.aulast=Humiston&rft.aufirst=R&rft.date=1992-10-01&rft.volume=73&rft.issue=43%2C+Suppl.&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1992 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - bathymetry; beaches; bedload; DELILAH; experimental studies; marine transport; nearshore environment; ocean circulation; ocean floors; sediment transport; suspended materials; tides; velocity ER - TY - JOUR T1 - Neither lipid modification nor processing of prolipoprotein is essential for the formation of murein-bound lipoprotein in Escherichia coli. AN - 73197936; 1527082 AB - The relationship between the modification and processing of prolipoprotein and the formation of murein-bound lipoprotein has been investigated using Escherichia coli mutants altered in the signal sequence of prolipoprotein and an E. coli strain producing OmpF-Lpp hybrid protein. The glyceride-modified prolipoprotein in mutant lppT20 and in globomycin-treated wild-type strain were covalently attached to the peptidoglycan. Likewise, the unmodified prolipoproteins in mutants lppL20, lppV20, and lppG21 were attached to the peptidoglycan. The OmpF-Lpp hybrid protein that is processed but not modified with lipid due to the absence of the cysteine-containing modification site in the hybrid protein was also covalently linked to the peptidoglycan. These results indicate that neither lipid modification nor the processing of prolipoprotein is essential for the formation of murein-bound lipoprotein in E. coli. In contrast, introduction of a charged amino acid residue such as Asp or Arg at the 14th position of prolipoprotein affected not only the lipid modification and processing of the mutant prolipoprotein but also the formation of murein-bound lipoprotein. Replacement of the Gly14 with Glu or Lys partially affected the lipid modification and processing of prolipoprotein; the peptidoglycan of the lppE14 and lppK14 mutants contained a reduced amount of mature lipoprotein but no mutant prolipoprotein. In addition, lpp mutants A20I23I24 and A20I23K24 were found to be defective in both lipid modification/processing of prolipoprotein and the formation of murein-bound lipoprotein. The defective formation of murein-bound lipoprotein in the latter mutants may be related to an alteration in the secondary structure at the modification/processing site of the mutant prolipoproteins. JF - The Journal of biological chemistry AU - Zhang, W Y AU - Inouye, M AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1992/09/25/ PY - 1992 DA - 1992 Sep 25 SP - 19631 EP - 19635 VL - 267 IS - 27 SN - 0021-9258, 0021-9258 KW - lpp KW - ompF KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Proteins KW - Lipoproteins KW - Peptides KW - Peptidoglycan KW - Protein Precursors KW - globomycin KW - 67076-74-8 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Processing, Post-Translational -- drug effects KW - Base Sequence KW - Protein Precursors -- metabolism KW - Bacterial Proteins -- metabolism KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Peptides -- pharmacology KW - Structure-Activity Relationship KW - Protein Conformation KW - Lipoproteins -- metabolism KW - Escherichia coli -- metabolism KW - Peptidoglycan -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73197936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Neither+lipid+modification+nor+processing+of+prolipoprotein+is+essential+for+the+formation+of+murein-bound+lipoprotein+in+Escherichia+coli.&rft.au=Zhang%2C+W+Y%3BInouye%2C+M%3BWu%2C+H+C&rft.aulast=Zhang&rft.aufirst=W&rft.date=1992-09-25&rft.volume=267&rft.issue=27&rft.spage=19631&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-22 N1 - Date created - 1992-10-22 N1 - Date revised - 2017-01-13 N1 - Gene symbol - lpp; ompF N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alterations of the carboxyl-terminal amino acid residues of Escherichia coli lipoprotein affect the formation of murein-bound lipoprotein. AN - 73184736; 1527073 AB - Mutations in the Escherichia coli lpp gene resulting in the alterations of the COOH-terminal region of the lipoprotein have been isolated by oligonucleotide-directed mutagenesis. As might be expected, substitution of Lys78 with Arg78 completely abolished the formation of murein-bound lipoprotein. Each of the following single amino acid substitutions did not significantly affect the formation of bound-form lipoprotein: Asp70 to Glu70 or Gly70; Lys75 to Thr75; and Tyr76 to His76, Ile76, or Leu76. In contrast, mutational alterations of Tyr76 to Cys76, Gly76, Asn76, Pro76, or Ser76 resulted in a reduction of the bound-form lipoprotein to levels of 14-32% of that in the wild-type strain. A common feature of these lpp COOH-terminal mutations affecting the formation of bound-form lipoprotein is the presence of a beta-turn secondary structure at the COOH-terminal region of all these mutant lipoproteins. In addition, substitution of Tyr76 to Asp76 or Glu76, and Arg77 to Asp77 or Leu77 also resulted in a reduced formation of the bound-form lipoprotein. These results suggest that the formation of murein-bound lipoprotein requires a COOH-terminal Lys residue and a positively charged COOH-terminal region. Furthermore, a beta-turn secondary structure in the COOH-terminal random coil region interferes with the attachment of the lipoprotein to the peptidoglycan. JF - The Journal of biological chemistry AU - Zhang, W Y AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1992/09/25/ PY - 1992 DA - 1992 Sep 25 SP - 19560 EP - 19564 VL - 267 IS - 27 SN - 0021-9258, 0021-9258 KW - lpp KW - Lipoproteins KW - 0 KW - Oligodeoxyribonucleotides KW - Peptidoglycan KW - Protein Precursors KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Protein Precursors -- metabolism KW - Sequence Alignment KW - Oligodeoxyribonucleotides -- chemistry KW - Protein Processing, Post-Translational KW - Isoelectric Point KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Structure-Activity Relationship KW - Lipoproteins -- metabolism KW - Escherichia coli -- metabolism KW - Peptidoglycan -- metabolism KW - Lipoproteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73184736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Alterations+of+the+carboxyl-terminal+amino+acid+residues+of+Escherichia+coli+lipoprotein+affect+the+formation+of+murein-bound+lipoprotein.&rft.au=Zhang%2C+W+Y%3BWu%2C+H+C&rft.aulast=Zhang&rft.aufirst=W&rft.date=1992-09-25&rft.volume=267&rft.issue=27&rft.spage=19560&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-22 N1 - Date created - 1992-10-22 N1 - Date revised - 2017-01-13 N1 - Gene symbol - lpp N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Intravenous glutamine fails to improve gut morphology after radiation injury. AN - 73308705; 1433777 AB - Male Sprague-Dawley rats housed in individual metabolic cages received total parenteral nutrients via chronic indwelling internal jugular catheters to determine whether supplementing parenteral nutrition with glutamine would accelerate recovery of small-bowel morphology after abdominal radiation. After recovering from catheter insertion for 3 days they received either 1000 cGy gamma radiation to the abdomen only or no radiation and immediately thereafter received isonitrogenous and isocaloric intravenous solutions containing either 0% or 2% glutamine at 1.58 mL/h for the next 5 days. Intestinal segments were then assayed for whole-bowel deoxyribose nucleic acid content and villus height. Irradiation caused a 40% decrement in these parameters, which were not restored by glutamine supplementation. Therefore, intravenous glutamine supplementation failed to accelerate recovery of small-bowel morphology in this model of combined surgical and radiation injury. JF - JPEN. Journal of parenteral and enteral nutrition AU - Scott, T E AU - Moellman, J R AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland. PY - 1992 SP - 440 EP - 444 VL - 16 IS - 5 SN - 0148-6071, 0148-6071 KW - Glutamine KW - 0RH81L854J KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Rats KW - Parenteral Nutrition, Total KW - Animals KW - Rats, Sprague-Dawley KW - Injections, Intravenous KW - DNA -- analysis KW - Time Factors KW - Male KW - Radiation Injuries, Experimental -- pathology KW - Intestines -- pathology KW - Radiation Injuries, Experimental -- therapy KW - Intestines -- injuries KW - Glutamine -- therapeutic use KW - Intestines -- radiation effects KW - Glutamine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73308705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JPEN.+Journal+of+parenteral+and+enteral+nutrition&rft.atitle=Intravenous+glutamine+fails+to+improve+gut+morphology+after+radiation+injury.&rft.au=Scott%2C+T+E%3BMoellman%2C+J+R&rft.aulast=Scott&rft.aufirst=T&rft.date=1992-09-01&rft.volume=16&rft.issue=5&rft.spage=440&rft.isbn=&rft.btitle=&rft.title=JPEN.+Journal+of+parenteral+and+enteral+nutrition&rft.issn=01486071&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-22 N1 - Date created - 1992-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The protein-phosphatase inhibitor okadaic acid mimics MSH-induced and melatonin-reversible melanosome dispersion in Xenopus laevis melanophores. AN - 73251421; 1329076 AB - The present study describes the ability of 315 nM okadaic acid to induce melanosome dispersion in cultured Xenopus laevis melanophores. This effect of okadaic acid is similar to that of a-melanocyte stimulating hormone (MSH) and can be reversed by melatonin treatment; it indicates that a member of the protein-phosphatase 1 or 2A families must be active for maintenance of the aggregated state. Higher concentrations of okadaic acid (1 microM) attenuate the response of Xenopus melanophores to melatonin leading to the hypothesis that melatonin action is mediated by the calcium/calmodulin activated phosphatase 2B. This hypothesis seems unlikely, however, since the calcium/calmodulin inhibitors TFP and W7 do not prevent melatonin-induced pigment aggregation, but instead induce aggregation on their own. JF - Pigment cell research AU - Cozzi, B AU - Rollag, M D AD - Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1992/09// PY - 1992 DA - September 1992 SP - 148 EP - 154 VL - 5 IS - 3 SN - 0893-5785, 0893-5785 KW - Calmodulin KW - 0 KW - Ethers, Cyclic KW - Sulfonamides KW - Okadaic Acid KW - 1W21G5Q4N2 KW - W 7 KW - 65595-90-6 KW - Melanocyte-Stimulating Hormones KW - 9002-79-3 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Melatonin KW - JL5DK93RCL KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calmodulin -- metabolism KW - Calcium -- metabolism KW - Xenopus laevis KW - Melatonin -- pharmacology KW - Animals KW - Cells, Cultured -- drug effects KW - Melanocyte-Stimulating Hormones -- antagonists & inhibitors KW - Melanocyte-Stimulating Hormones -- pharmacology KW - Phosphoprotein Phosphatases -- antagonists & inhibitors KW - Melanocytes -- drug effects KW - Ethers, Cyclic -- pharmacology KW - Melanophores -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73251421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pigment+cell+research&rft.atitle=The+protein-phosphatase+inhibitor+okadaic+acid+mimics+MSH-induced+and+melatonin-reversible+melanosome+dispersion+in+Xenopus+laevis+melanophores.&rft.au=Cozzi%2C+B%3BRollag%2C+M+D&rft.aulast=Cozzi&rft.aufirst=B&rft.date=1992-09-01&rft.volume=5&rft.issue=3&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Pigment+cell+research&rft.issn=08935785&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-12 N1 - Date created - 1992-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin. AN - 73180705; 1526078 AB - Terfenadine is a nonsedating H1-antagonist that when overdosed, used with hepatic compromise, or when given with ketoconazole results in accumulation of parent terfenadine, prolongation of the QT interval, and torsades de pointes in susceptible patients. Nine subjects were given the recommended dose of terfenadine (60 mg every 12 hours) for 7 days before initiation of oral erythromycin (500 mg every 8 hours). All subjects increased metabolite concentrations after the addition of erythromycin for 1 week. The maximum concentration of metabolite increased by a mean of 107% and the mean metabolite area under the concentration-time curve increased by 170%. Three subjects accumulated unmetabolized terfenadine after administration of erythromycin for 1 week. Electrocardiographic data revealed changes in QT intervals and ST-U complexes in a subset of subjects who accumulated terfenadine. We conclude that erythromycin alters the metabolism of terfenadine, leading to accumulation of terfenadine in certain individuals that is associated with altered cardiac repolarization. JF - Clinical pharmacology and therapeutics AU - Honig, P K AU - Woosley, R L AU - Zamani, K AU - Conner, D P AU - Cantilena, L R AD - Division of Clinical Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1992/09// PY - 1992 DA - September 1992 SP - 231 EP - 238 VL - 52 IS - 3 SN - 0009-9236, 0009-9236 KW - Erythromycin KW - 63937KV33D KW - Terfenadine KW - 7BA5G9Y06Q KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Administration, Oral KW - Drug Interactions KW - Humans KW - Adult KW - Heart -- physiology KW - Heart -- drug effects KW - Myocardium -- metabolism KW - Male KW - Female KW - Terfenadine -- pharmacology KW - Terfenadine -- pharmacokinetics KW - Erythromycin -- pharmacology KW - Erythromycin -- administration & dosage KW - Electrocardiography -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73180705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Changes+in+the+pharmacokinetics+and+electrocardiographic+pharmacodynamics+of+terfenadine+with+concomitant+administration+of+erythromycin.&rft.au=Honig%2C+P+K%3BWoosley%2C+R+L%3BZamani%2C+K%3BConner%2C+D+P%3BCantilena%2C+L+R&rft.aulast=Honig&rft.aufirst=P&rft.date=1992-09-01&rft.volume=52&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-22 N1 - Date created - 1992-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Purification and characterization of the diphtheria toxin repressor. AN - 73132173; 1502169 AB - The diphtheria toxin repressor gene (dtxR) encodes a protein (DtxR) that regulates transcription of the diphtheria toxin gene (tox) by an iron-dependent mechanism. Cloned dtxR was expressed in Escherichia coli from the phage T7 gene 10 promoter, and DtxR was purified. Specific binding of DtxR to the tox+ operator was dependent on reduction of DtxR and the presence of ferrous ions. DtxR protected a sequence of approximately 30 nucleotide pairs, partially overlapping the tox promoter and containing a region of dyad symmetry, from digestion by DNase I. DtxR exhibited very little binding to the mutant tox-201 operator region and failed to bind to the promoter/operator region of the ferric uptake regulation (fur) gene of E. coli. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Schmitt, M P AU - Twiddy, E M AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4977. Y1 - 1992/08/15/ PY - 1992 DA - 1992 Aug 15 SP - 7576 EP - 7580 VL - 89 IS - 16 SN - 0027-8424, 0027-8424 KW - dtxR KW - fur KW - tox KW - tox-201 KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - DNA-Binding Proteins KW - Diphtheria Toxin KW - DtxR protein, Corynebacterium diphtheriae KW - Oligodeoxyribonucleotides KW - Recombinant Fusion Proteins KW - Index Medicus KW - DNA, Bacterial -- isolation & purification KW - Recombinant Fusion Proteins -- isolation & purification KW - Cloning, Molecular KW - Recombinant Fusion Proteins -- metabolism KW - Oxidation-Reduction KW - Polymerase Chain Reaction KW - Alleles KW - Base Sequence KW - Promoter Regions, Genetic KW - Chromatography, DEAE-Cellulose KW - DNA, Bacterial -- genetics KW - Restriction Mapping KW - Molecular Sequence Data KW - Gene Expression Regulation, Bacterial KW - Bacterial Proteins -- genetics KW - Genes, Bacterial KW - Corynebacterium diphtheriae -- metabolism KW - Operon KW - Bacterial Proteins -- metabolism KW - DNA-Binding Proteins -- genetics KW - Bacterial Proteins -- isolation & purification KW - Corynebacterium diphtheriae -- genetics KW - Escherichia coli -- genetics KW - Transcription, Genetic KW - Diphtheria Toxin -- genetics KW - DNA-Binding Proteins -- isolation & purification KW - Genes, Regulator KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73132173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Purification+and+characterization+of+the+diphtheria+toxin+repressor.&rft.au=Schmitt%2C+M+P%3BTwiddy%2C+E+M%3BHolmes%2C+R+K&rft.aulast=Schmitt&rft.aufirst=M&rft.date=1992-08-15&rft.volume=89&rft.issue=16&rft.spage=7576&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-15 N1 - Date created - 1992-09-15 N1 - Date revised - 2017-01-13 N1 - Gene symbol - dtxR; fur; tox; tox-201 N1 - SuppNotes - Cited By: Nat New Biol. 1971 Sep 1;233(35):8-11 [4999827] J Virol. 1976 Apr;18(1):235-44 [815566] Proc Natl Acad Sci U S A. 1983 Nov;80(22):6853-7 [6316330] J Bacteriol. 1983 Apr;154(1):245-52 [6403502] Infect Immun. 1981 Jun;32(3):1034-44 [7019086] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Infect Immun. 1977 Oct;18(1):203-9 [409685] Infect Immun. 1978 Mar;19(3):785-91 [417030] Infect Immun. 1991 Nov;59(11):3903-8 [1718867] Proc Natl Acad Sci U S A. 1990 Aug;87(15):5968-72 [2116013] Microb Pathog. 1990 Oct;9(4):267-73 [2151460] J Bacteriol. 1985 Sep;163(3):1114-9 [2411714] Eur J Biochem. 1988 May 2;173(3):537-46 [2836193] Microbiol Rev. 1987 Dec;51(4):509-18 [2963952] Mol Gen Genet. 1985;200(1):110-3 [2993806] J Bacteriol. 1988 Dec;170(12):5949-52 [3142864] J Bacteriol. 1987 Jun;169(6):2624-30 [3294800] J Bacteriol. 1987 Oct;169(10):4759-64 [3308853] J Virol. 1969 Jun;3(6):586-98 [4978942] Infect Immun. 1983 Dec;42(3):914-23 [6196297] Nucleic Acids Res. 1983 Jan 11;11(1):141-58 [6306561] Nucleic Acids Res. 1983 Oct 11;11(19):6589-95 [6314249] Science. 1983 Aug 26;221(4613):855-8 [6348945] J Hyg (Lond). 1984 Dec;93(3):405-17 [6439780] J Virol. 1981 Mar;37(3):936-45 [6785449] Br J Exp Pathol. 1953 Apr;34(2):221-9 [13051533] Infect Immun. 1991 Jun;59(6):1899-904 [1828057] Annu Rev Biochem. 1990;59:933-69 [2197994] Infect Immun. 1989 Oct;57(10):3221-5 [2506133] Biol Met. 1988;1(1):62-8 [2856356] Infect Immun. 1988 Sep;56(9):2430-6 [3044999] Proc Natl Acad Sci U S A. 1985 Feb;82(4):1074-8 [3156376] Proc Natl Acad Sci U S A. 1974 Jan;71(1):11-5 [4204202] Annu Rev Biochem. 1977;46:69-94 [20040] Methods Enzymol. 1980;65(1):499-560 [6246368] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transcription analysis and nucleotide sequence of tox promoter/operator mutants of corynebacteriophage beta. AN - 73320428; 1453929 AB - The production of diphtheria toxin (DT) by Corynebacterium diphtheriae C7 (beta) is transcriptionally regulated by the iron-dependent diphtheria toxin repressor, DtxR. Transcription of the tox gene was studied in wild-type C. diphtheriae C7 (beta) and in lysogens carrying mutants of beta that determine insensitivity to inhibition of DT production by iron. Under low iron conditions in all strains, tox-specific mRNA appeared and DT production began during late-log phase, and they increased to maximal levels at stationary phase. Under high iron conditions, tox-specific mRNA and DT production were strongly repressed in C7 (beta) but only partially repressed in C7 (beta tox-202) and C7 (beta tox-201). Under high and low iron conditions, DT production and tox-specific mRNA levels were greater in C7 (beta tox-201) and C7 (beta tox-202) than in wild-type C7 (beta). Addition of iron or rifampicin to low iron cultures of C. diphtheriae C7 (beta) repressed tox-mRNA production promptly and with a similar time course. In contrast, repression of tox-mRNA synthesis in C. diphtheriae C7 (beta tox-201) occurred promptly after addition of rifampicin but more slowly after addition of iron. Nucleotide sequence analysis revealed single G to A mutations at positions -47 and -48, within the preferred '-10' sequence of the tox promoter, in beta tox-201 and beta tox-202, respectively. The single nucleotide substitutions in the tox-201 and tox-202 regulatory alleles, therefore, have pleiotropic effects, causing increased activity of the promoter and partial resistance of the operator to iron-dependent repression. JF - Microbial pathogenesis AU - Krafft, A E AU - Tai, S P AU - Coker, C AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 85 EP - 92 VL - 13 IS - 2 SN - 0882-4010, 0882-4010 KW - dtxR KW - tox KW - Bacterial Proteins KW - 0 KW - DNA, Single-Stranded KW - DNA-Binding Proteins KW - Diphtheria Toxin KW - DtxR protein, Corynebacterium diphtheriae KW - RNA, Messenger KW - Siderophores KW - Index Medicus KW - Base Sequence KW - Siderophores -- metabolism KW - Bacterial Proteins -- metabolism KW - Molecular Sequence Data KW - RNA, Messenger -- genetics KW - Mutagenesis KW - DNA-Binding Proteins -- metabolism KW - Promoter Regions, Genetic KW - Operator Regions, Genetic KW - Bacteriophages -- genetics KW - Corynebacterium diphtheriae -- genetics KW - Transcription, Genetic KW - Diphtheria Toxin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73320428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+pathogenesis&rft.atitle=Transcription+analysis+and+nucleotide+sequence+of+tox+promoter%2Foperator+mutants+of+corynebacteriophage+beta.&rft.au=Krafft%2C+A+E%3BTai%2C+S+P%3BCoker%2C+C%3BHolmes%2C+R+K&rft.aulast=Krafft&rft.aufirst=A&rft.date=1992-08-01&rft.volume=13&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Microbial+pathogenesis&rft.issn=08824010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-06 N1 - Date created - 1993-01-06 N1 - Date revised - 2017-01-13 N1 - Gene symbol - dtxR; tox N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neurovascular effects of reactive oxygen intermediates produced by photoradiation. AN - 73196396; 1528407 AB - These experiments examined the effect of reactive oxygen intermediates, produced by laser illumination of the photosensitizer hematoporphyrin derivative, on the accumulation and release of norepinephrine from sympathetic nerve terminals. Using an isolated, spirally cut, superfused caudal artery of the rat, basal overflow of norepinephrine (NE) was significantly increased both during and after generation of reactive oxygen intermediates. Generation of reactive oxygen intermediates increased overflow of NE in vascular preparations in which release of NE had previously been elevated by the continuous superfusion of Krebs' solution, containing high concentrations of potassium (40 mM). Calcium free solutions did not block the overflow of norepinephrine augmented by reactive oxygen intermediates. This increase in overflow was due both to an increase in release of NE and an inhibition of accumulation of NE. JF - Neuropharmacology AU - Freas, W AU - Llave, R AU - Hart, J L AU - Kobayashi, Y AU - Nagel, J AU - Muldoon, S M AD - Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 809 EP - 815 VL - 31 IS - 8 SN - 0028-3908, 0028-3908 KW - Free Radicals KW - 0 KW - Hematoporphyrins KW - Potassium Chloride KW - 660YQ98I10 KW - Cocaine KW - I5Y540LHVR KW - Oxygen KW - S88TT14065 KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Space life sciences KW - Animals KW - Hematoporphyrins -- radiation effects KW - Perfusion KW - Hematoporphyrins -- metabolism KW - Potassium Chloride -- pharmacology KW - Rats, Inbred Strains KW - Rats KW - Nerve Endings -- physiology KW - In Vitro Techniques KW - Lasers KW - Cocaine -- pharmacology KW - Male KW - Nerve Endings -- drug effects KW - Oxygen -- toxicity KW - Norepinephrine -- metabolism KW - Sympathetic Nervous System -- drug effects KW - Muscle, Smooth, Vascular -- drug effects KW - Muscle, Smooth, Vascular -- metabolism KW - Oxygen -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73196396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Neurovascular+effects+of+reactive+oxygen+intermediates+produced+by+photoradiation.&rft.au=Freas%2C+W%3BLlave%2C+R%3BHart%2C+J+L%3BKobayashi%2C+Y%3BNagel%2C+J%3BMuldoon%2C+S+M&rft.aulast=Freas&rft.aufirst=W&rft.date=1992-08-01&rft.volume=31&rft.issue=8&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-19 N1 - Date created - 1992-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Unnecessary mastectomy for gynecomastia in testicular cancer patient. AN - 73195842; 1382250 AB - A young man presented with a 4-month history of progressive, bilateral tender gynecomastia and underwent a bilateral subcutaneous mastectomy without regard for a possible occult testicular tumor. Following the mastectomy, metastatic testicular cancer was discovered; the patient had an overlooked scrotal mass and a very elevated serum human chorionic gonadotropin tumor marker. The possibility of testicular tumor must be considered in any male, especially those in the younger age group, who present with gynecomastia. JF - Military medicine AU - Moul, J W AU - Moellman, J R AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 433 EP - 434 VL - 157 IS - 8 SN - 0026-4075, 0026-4075 KW - Chorionic Gonadotropin KW - 0 KW - Bleomycin KW - 11056-06-7 KW - Etoposide KW - 6PLQ3CP4P3 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - United States KW - Bleomycin -- administration & dosage KW - Combined Modality Therapy KW - Humans KW - Retroperitoneal Neoplasms -- drug therapy KW - Cisplatin -- administration & dosage KW - Orchiectomy KW - Chorionic Gonadotropin -- blood KW - Retroperitoneal Neoplasms -- secondary KW - Etoposide -- administration & dosage KW - Adult KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Testicular Neoplasms -- therapy KW - Gynecomastia -- etiology KW - Mastectomy, Subcutaneous KW - Military Personnel KW - Teratoma -- therapy KW - Gynecomastia -- surgery KW - Choriocarcinoma -- therapy KW - Teratoma -- secondary KW - Choriocarcinoma -- secondary KW - Testicular Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73195842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Unnecessary+mastectomy+for+gynecomastia+in+testicular+cancer+patient.&rft.au=Moul%2C+J+W%3BMoellman%2C+J+R&rft.aulast=Moul&rft.aufirst=J&rft.date=1992-08-01&rft.volume=157&rft.issue=8&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-22 N1 - Date created - 1992-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cardio-respiratory changes and mortality in the conscious rat induced by (+)- and (+/-)-anatoxin-a. AN - 73194383; 1523681 AB - Anatoxin-a (AnTx-a) is a potent nicotinic cholinergic receptor agonist. The relative potencies of the (+)-AnTx-a and the racemic mixture (+/-)-AnTx-a were investigated in the conscious rat by comparing their effects on mean arterial blood pressure (BP), heart rate (HR), blood oxygen and carbon dioxide pressures (pO2 and pCO2, respectively), acid-base balance (pH) and mortality. The present experiments show that while both forms of AnTx-a produce dose-dependent increases in BP and decreases in HR, (+)-AnTx-a is about 10-fold more potent than the optically inactive isomer. (+)-AnTx-a was also 6-fold more potent than (+/-)-AnTx-a in producing severe hypoxemia, and more than 4-fold as potent as the (+/-)-AnTx-a in producing significant hypercapnia accompanied with severe acidosis. The approximate median lethal dose (LD50) of (+)-AnTx-a was about 5-fold less than that of (+/-)-AnTx-a. We conclude that (+)-AnTx-a is more potent than the (+/-)-AnTx-a racemic mixture in causing detrimental cardio-respiratory changes and therefore increased mortality in the rat. JF - Toxicon : official journal of the International Society on Toxinology AU - Adeyemo, O M AU - Sirén, A L AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD 20889-4799. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 899 EP - 905 VL - 30 IS - 8 SN - 0041-0101, 0041-0101 KW - Bacterial Toxins KW - 0 KW - Marine Toxins KW - Microcystins KW - Tropanes KW - cyanobacterial toxin KW - anatoxin a KW - 80023A73NK KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Heart Rate -- drug effects KW - Lethal Dose 50 KW - Hypercapnia -- chemically induced KW - Hypoxia -- chemically induced KW - Blood Gas Analysis KW - Blood Pressure -- drug effects KW - Male KW - Heart Diseases -- chemically induced KW - Marine Toxins -- administration & dosage KW - Bacterial Toxins -- toxicity KW - Bacterial Toxins -- administration & dosage KW - Respiration Disorders -- chemically induced KW - Marine Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73194383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Cardio-respiratory+changes+and+mortality+in+the+conscious+rat+induced+by+%28%2B%29-+and+%28%2B%2F-%29-anatoxin-a.&rft.au=Adeyemo%2C+O+M%3BSir%C3%A9n%2C+A+L&rft.aulast=Adeyemo&rft.aufirst=O&rft.date=1992-08-01&rft.volume=30&rft.issue=8&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-10-09 N1 - Date created - 1992-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Psychological responses of rescue workers: fire fighters and trauma. AN - 73110934; 1497102 AB - The psychological responses of two groups of fire fighters were examined following the performance of rescue work. Four types of responses were reported: identification with the victims, feelings of helplessness and guilt, fear of the unknown, and physiological reactions. Stress was found to be mediated by availability of social support, type of leadership, level of training, and use of rituals. Implications of these findings for preventive intervention measures are discussed. JF - The American journal of orthopsychiatry AU - Fullerton, C S AU - McCarroll, J E AU - Ursano, R J AU - Wright, K M AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Md. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 371 EP - 378 VL - 62 IS - 3 SN - 0002-9432, 0002-9432 KW - Index Medicus KW - Psychotherapy, Group KW - Identification (Psychology) KW - Helplessness, Learned KW - Fear KW - Humans KW - Attitude to Death KW - Adult KW - Middle Aged KW - Iowa KW - Male KW - Multiple Trauma -- psychology KW - Fires KW - Stress Disorders, Post-Traumatic -- psychology KW - Arousal KW - Adaptation, Psychological KW - Relief Work KW - Accidents, Aviation -- psychology KW - Occupational Diseases -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73110934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+orthopsychiatry&rft.atitle=Psychological+responses+of+rescue+workers%3A+fire+fighters+and+trauma.&rft.au=Fullerton%2C+C+S%3BMcCarroll%2C+J+E%3BUrsano%2C+R+J%3BWright%2C+K+M&rft.aulast=Fullerton&rft.aufirst=C&rft.date=1992-07-01&rft.volume=62&rft.issue=3&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+orthopsychiatry&rft.issn=00029432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-10 N1 - Date created - 1992-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The status of the p53 gene in human papilloma virus positive or negative cervical carcinoma cell lines. AN - 73089376; 1322252 AB - We have analyzed p53 gene alterations in five cervical cancer derived cell lines. Two of the five cervical cancer cell lines, HTB31 (C-33A) and 32 (HT-3), harbored missense mutations in codons 273 and 245 respectively, whereas the other three tumor cell lines, HTB33 (ME180), 34 (MS751) and 35 (SIHA), did not reveal any mutation in the p53 coding sequence spanning codons 126-307. Although all the tumor cell lines express comparable levels of p53 RNA, only HTB31 and HTB32 contain high or detectable levels respectively of p53 protein. The other three tumor cell lines, where neither p53 mutation nor the expression of p53 protein could be detected, were found to harbor human papilloma virus (HPV) 16 or 18. The inactivation of the wild-type p53 function resulting from a missense mutation, or the lack of detectable wild-type p53 protein due to the translational/post-translational deregulation of p53 protein levels may be the contributing factor in the tumorigenicity of these five cases of cervical cancer. The lack of detectable p53 protein in HTB33, 34 and 35 associates with the presence of either HPV16 or -18 in these cell lines. JF - Carcinogenesis AU - Srivastava, S AU - Tong, Y A AU - Devadas, K AU - Zou, Z Q AU - Chen, Y AU - Pirollo, K F AU - Chang, E H AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 1273 EP - 1275 VL - 13 IS - 7 SN - 0143-3334, 0143-3334 KW - p53 KW - Codon KW - 0 KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Base Sequence KW - Humans KW - Amino Acid Sequence KW - Female KW - Genes, p53 KW - Tumor Suppressor Protein p53 -- isolation & purification KW - Papillomaviridae -- isolation & purification KW - Uterine Cervical Neoplasms -- microbiology KW - Uterine Cervical Neoplasms -- genetics KW - Tumor Suppressor Protein p53 -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73089376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+status+of+the+p53+gene+in+human+papilloma+virus+positive+or+negative+cervical+carcinoma+cell+lines.&rft.au=Srivastava%2C+S%3BTong%2C+Y+A%3BDevadas%2C+K%3BZou%2C+Z+Q%3BChen%2C+Y%3BPirollo%2C+K+F%3BChang%2C+E+H&rft.aulast=Srivastava&rft.aufirst=S&rft.date=1992-07-01&rft.volume=13&rft.issue=7&rft.spage=1273&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-28 N1 - Date created - 1992-08-28 N1 - Date revised - 2017-01-13 N1 - Gene symbol - p53 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Serotonin-stimulated release of [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens: a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine. AN - 73058490; 1352552 AB - Release of preloaded radiolabeled dopamine ([3H]DA) elicited by several agents from terminal fields of mesolimbic and nigrostriatal projections in rats was compared. Several similarities between the two areas were observed. For example, potassium, which stimulates release both directly, through altering the potential across the membrane of the dopaminergic neuron, as well as indirectly, presumably by releasing endogenous excitatory neurotransmitters, exhibited some similarities to release stimulated by L-glutamate and N-methyl-D-aspartic acid. These included sensitivity to tetrodotoxin (TTX), Mg++ and Ca++. In contrast, release of [3H]DA stimulated by serotonin (5-HT), like that stimulated by D-amphetamine, depended upon a functional dopamine transport system and was less sensitive to TTX, Mg++ and Ca++. 5-HT-stimulated [3H]DA release in striatum (STR) and nucleus accumbens (NACC) was not modified by antagonists at 5-HT2 or 5-HT3 receptors. Differences were observed in release of [3H]DA from STR and NACC. Elevated potassium (20 mM) released about twice as much [3H]DA from NACC as it did from STR. 5-HT was also able to release more [3H]DA from NACC than from STR. Conversely, D-amphetamine released more [3H]DA from STR than from NACC. TTX increased release stimulated by potassium in STR, but decreased release stimulated by potassium in NACC. These observations suggest that receptor- and non-receptor-mediated mechanisms may contribute to regulation of [3H]DA release in mesolimbic and nigrostriatal areas of the brain. It is possible that endogenous 5-HT in STR or NACC acts as a local regulator of DA release acting via a transport-dependent mechanism.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Jacocks, H M AU - Cox, B M AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 356 EP - 364 VL - 262 IS - 1 SN - 0022-3565, 0022-3565 KW - Glutamates KW - 0 KW - Neurotransmitter Uptake Inhibitors KW - Piperazines KW - Serotonin Antagonists KW - Glutamic Acid KW - 3KX376GY7L KW - N-Methylaspartate KW - 6384-92-5 KW - vanoxerine KW - 90X28IKH43 KW - Amphetamine KW - CK833KGX7E KW - Potassium KW - RWP5GA015D KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Drug Interactions KW - Serotonin Antagonists -- pharmacology KW - Neurotransmitter Uptake Inhibitors -- pharmacology KW - Piperazines -- pharmacology KW - Male KW - N-Methylaspartate -- pharmacology KW - Glutamates -- pharmacology KW - Brain -- drug effects KW - Potassium -- pharmacology KW - Dopamine -- metabolism KW - Brain -- metabolism KW - Amphetamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73058490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Serotonin-stimulated+release+of+%5B3H%5Ddopamine+via+reversal+of+the+dopamine+transporter+in+rat+striatum+and+nucleus+accumbens%3A+a+comparison+with+release+elicited+by+potassium%2C+N-methyl-D-aspartic+acid%2C+glutamic+acid+and+D-amphetamine.&rft.au=Jacocks%2C+H+M%3BCox%2C+B+M&rft.aulast=Jacocks&rft.aufirst=H&rft.date=1992-07-01&rft.volume=262&rft.issue=1&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-11 N1 - Date created - 1992-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Economic Development in Iraq: Factors Underlying the Relative Deterioration of Human Capital Formation AN - 61656935; 199301512 AB - Evidence is presented that demonstrates the drastic decline in human development in Iraq during the 1980s. In contrast, Iran was able to expand its human capital during the 1980s by allocating a large proportion of its assets to human capital development. It is suggested that an important aspect of human capital development -- improvements in literacy -- has been helped by the high rate of participation in Iraq's military. 9 References. W. Howard JF - Journal of Economic Issues AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1992/06// PY - 1992 DA - June 1992 SP - 615 EP - 622 VL - 26 IS - 2 SN - 0021-3624, 0021-3624 KW - human capital development, Iraq, 1980s KW - Human Capital KW - Economic Development KW - Iraq KW - article KW - 8370: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61656935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Economic+Issues&rft.atitle=Economic+Development+in+Iraq%3A+Factors+Underlying+the+Relative+Deterioration+of+Human+Capital+Formation&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1992-06-01&rft.volume=26&rft.issue=2&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Journal+of+Economic+Issues&rft.issn=00213624&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Human Capital; Iraq; Economic Development ER - TY - JOUR T1 - Manpower Options in a Small Labor-Importing State: The Influence of Ethnic Composition on Kuwait's Development AN - 61305120; 9300681 AB - The impact of using Arab vs Asian expatriate workers on Kuwait's development is examined through application of the Dutch disease model & regression analysis of Kuwait's economic sectoral outputs. Results suggest that Asian workers made weak positive contributions to agricultural output & fishing while Arab workers made strong contributions to food production, textiles, paper products, petroleum refining, & private services. Overall, the Asian expatriate workforce made much less positive contributions to the country's expansion than Arab expatriate workers, indicating that Arabization coincides with Kuwait's economic objectives. 8 Tables. JF - International Migration/Migrations Internationales/Migraciones Internationales AU - Looney, R E AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1992/06// PY - 1992 DA - June 1992 SP - 175 EP - 200 VL - 30 IS - 2 SN - 0020-7985, 0020-7985 KW - Kuwait's development KW - Arab vs Asian expatriate workers KW - Asian Cultural Groups KW - Foreign Workers KW - Arab Cultural Groups KW - Economic Development KW - Labor Supply KW - Kuwait KW - article KW - 0749: social change and economic development; market structures & consumer behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61305120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Migration%2FMigrations+Internationales%2FMigraciones+Internationales&rft.atitle=Manpower+Options+in+a+Small+Labor-Importing+State%3A+The+Influence+of+Ethnic+Composition+on+Kuwait%27s+Development&rft.au=Looney%2C+R+E&rft.aulast=Looney&rft.aufirst=R&rft.date=1992-06-01&rft.volume=30&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=International+Migration%2FMigrations+Internationales%2FMigraciones+Internationales&rft.issn=00207985&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IMIGAS N1 - SubjectsTermNotLitGenreText - Labor Supply; Foreign Workers; Kuwait; Economic Development; Arab Cultural Groups; Asian Cultural Groups ER - TY - JOUR T1 - Breast cancer detection in relation to oral contraception. AN - 72950124; 1588351 AB - Analyses of tumor size and breast cancer stage were used to determine whether biased detection of breast cancer could have materially influenced estimates of risk associated with use of oral contraceptives. In a population-based case-control study conducted from 1980-1982, surveillance for breast cancer by breast exams, but not mammography, was found to be strongly linked to use of oral contraceptives. Tumors were slightly smaller and less likely to be late-stage (TNM stage III or IV) in patients who had used oral contraceptives. The net effect of any diagnostic bias on advancing the date of cancer diagnosis, whether from breast exams or other sources, was estimated to be less than 8 weeks. This corresponds to spuriously increasing the risk of early-occurring breast cancer in oral contraceptive users by at most 2.4% (relative risk = 1.024). JF - Journal of clinical epidemiology AU - Schlesselman, J J AU - Stadel, B V AU - Korper, M AU - Yu, W AU - Wingo, P A AD - Department of Preventive Medicine & Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 449 EP - 459 VL - 45 IS - 5 SN - 0895-4356, 0895-4356 KW - Contraceptives, Oral KW - 0 KW - Index Medicus KW - Population KW - United States KW - Age Factors KW - Research Methodology KW - Breast Cancer KW - Oral Contraceptives KW - Contraceptive Methods KW - Developed Countries KW - Population Characteristics KW - Demographic Factors KW - Diseases KW - Family Planning KW - Contraceptive Usage--statistics KW - Size KW - North America KW - Americas KW - Studies KW - Cancer KW - Case Control Studies KW - Signs And Symptoms KW - Northern America KW - Neoplasms KW - Contraception KW - Risk Factors KW - Examinations And Diagnoses KW - Biology KW - Self-Examination KW - Mammography KW - Humans KW - Adult KW - Case-Control Studies KW - Breast -- pathology KW - Middle Aged KW - Bias (Epidemiology) KW - Time Factors KW - Menopause KW - Female KW - Contraceptives, Oral -- adverse effects KW - Breast Neoplasms -- pathology KW - Breast Neoplasms -- diagnosis KW - Breast Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72950124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=Breast+cancer+detection+in+relation+to+oral+contraception.&rft.au=Schlesselman%2C+J+J%3BStadel%2C+B+V%3BKorper%2C+M%3BYu%2C+W%3BWingo%2C+P+A&rft.aulast=Schlesselman&rft.aufirst=J&rft.date=1992-05-01&rft.volume=45&rft.issue=5&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-19 N1 - Date created - 1992-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Symptoms of Chronic Stress Following a Natural Disaster and Discovery of a Human-Made Hazard AN - 34823479; 200910-B7-0082476 (MB); 200910-30-0135453 (CE); 10903693 (EN) AB - Research on the acute and chronic effects of victimization by disaster has found that some patterns of response generalize across disasters of different origin and type. However, it is likely that variation in the nature of the victimizing event can affect long-term psychophysiological reactions. This study compared 23 flood victims with 27 people living near a leaking hazardous toxic waste dump and 27 control subjects. Self-report, behavioral, and physiological measures of stress were collected, all of which showed that 9 months after the announcement of the toxic hazard and the destructive flood, subjects living near the waste dump were more anxious, depressed, and alienated, less able to perform challenging tasks, and more aroused than were flood victims or control subjects. Residents of the landfill neighborhood also reported more feelings of helplessness than did any other subjects, and these feelings were significantly correlated with stress. Victimization associated with the toxic landfill appeared more likely to pose threats to victims' sense of control and to cause chronic emotional and psychophysiological problems than did the natural disaster. JF - Environment & Behavior AU - Baum, Andrew AU - Fleming, India AU - Israel, Ann AU - O'Keeffe, Mary K AD - Military Stress Studies Center at the Uniformed Services University of the Health Sciences in Bethesda, Maryland PY - 1992 SP - 347 EP - 365 PB - Sage Publications, 2455 Teller Road, Thousand Oaks, CA, 91320, USA, [mailto:sagesciencesagepub.com], [URL:http://www.sagepub.com] VL - 24 IS - 3 SN - 0013-9165, 0013-9165 KW - Materials Business File (MB); Civil Engineering (CE); Environmental Engineering (EN) KW - Floods KW - Stresses KW - Landfills KW - Natural disasters KW - Toxicology KW - Disasters KW - Waste dumps KW - Toxic KW - Article KW - EE 60:Waste Management (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/34823479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+%26+Behavior&rft.atitle=Symptoms+of+Chronic+Stress+Following+a+Natural+Disaster+and+Discovery+of+a+Human-Made+Hazard&rft.au=Baum%2C+Andrew%3BFleming%2C+India%3BIsrael%2C+Ann%3BO%27Keeffe%2C+Mary+K&rft.aulast=Baum&rft.aufirst=Andrew&rft.date=1992-05-01&rft.volume=24&rft.issue=3&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Environment+%26+Behavior&rft.issn=00139165&rft_id=info:doi/10.1177%2F0013916592243004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Number of references - 30 N1 - Last updated - 2011-11-14 DO - http://dx.doi.org/10.1177/0013916592243004 ER - TY - JOUR T1 - Characterization of hybrid toxins produced in Escherichia coli by assembly of A and B polypeptides from type I and type II heat-labile enterotoxins. AN - 72844467; 1548088 AB - The genes encoding the individual A and B polypeptides of the type I enterotoxin LTp-I and type II enterotoxins LT-IIa and LT-IIb were cloned and tested for complementation in Escherichia coli. Each gene encoding an A polypeptide was cloned into pACYC184, and each gene encoding a B polypeptide was cloned into the compatible plasmid Bluescript KS+. In addition, operon fusions representing all combinations of A and B genes were constructed in Bluescript KS+. Extracts from strains of E. coli expressing each combination of A and B genes, either from compatible plasmids or from operon fusions, were tested for immunoreactive holotoxin by radioimmunoassays and for toxicity by Y1 adrenal cell assays. Biologically active holotoxin was detected in each case, but the toxicity of extracts containing the hybrid toxins was usually less than that of extracts containing the wild-type holotoxins. The ganglioside-binding activity of each holotoxin was tested, and in each case, the B polypeptide determined the ganglioside-binding specificity. The A and B polypeptides of the type II heat-labile enterotoxins were also shown to form holotoxin in vitro without exposure to denaturing conditions, in contrast to the polypeptides of the type I enterotoxins that failed to form holotoxin in vitro under comparable conditions. These findings suggest that type I and type II enterotoxins have conserved structural features that permit their A and B polypeptides to form hybrid holotoxins, although the B polypeptides of the type I and type II enterotoxins have very little amino acid sequence homology. JF - Infection and immunity AU - Connell, T D AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 1653 EP - 1661 VL - 60 IS - 4 SN - 0019-9567, 0019-9567 KW - Bacterial Toxins KW - 0 KW - Enterotoxins KW - Escherichia coli Proteins KW - Gangliosides KW - Glycosides KW - Triterpenes KW - heat-labile enterotoxin, E coli KW - stichoposide KW - 37341-37-0 KW - Index Medicus KW - Glycosides -- toxicity KW - Triterpenes -- chemical synthesis KW - Triterpenes -- metabolism KW - Plasmids KW - Glycosides -- chemical synthesis KW - Radioimmunoassay KW - Cloning, Molecular KW - Glycosides -- metabolism KW - In Vitro Techniques KW - Recombination, Genetic KW - Triterpenes -- toxicity KW - Escherichia coli KW - Genetic Complementation Test KW - Gangliosides -- metabolism KW - Bacterial Toxins -- toxicity KW - Enterotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72844467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Characterization+of+hybrid+toxins+produced+in+Escherichia+coli+by+assembly+of+A+and+B+polypeptides+from+type+I+and+type+II+heat-labile+enterotoxins.&rft.au=Connell%2C+T+D%3BHolmes%2C+R+K&rft.aulast=Connell&rft.aufirst=T&rft.date=1992-04-01&rft.volume=60&rft.issue=4&rft.spage=1653&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-23 N1 - Date created - 1992-04-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1986 Nov;54(2):587-9 [3533784] J Bacteriol. 1986 Feb;165(2):348-52 [3511028] Infect Immun. 1983 Dec;42(3):914-23 [6196297] Biochem J. 1986 Sep 1;238(2):313-22 [3541910] Infect Immun. 1985 Apr;48(1):73-7 [3884513] Infect Immun. 1981 Nov;34(2):337-40 [6171517] Nucleic Acids Res. 1981 Jul 10;9(13):2989-98 [6269067] FEBS Lett. 1984 Apr 24;169(2):241-6 [6325242] Infect Immun. 1984 Mar;43(3):1027-32 [6365779] Microbiol Rev. 1984 Sep;48(3):199-221 [6436655] Nature. 1980 Dec 4;288(5790):499-501 [7003397] Infect Immun. 1981 Sep;33(3):677-82 [7026442] Infect Immun. 1983 May;40(2):647-52 [6302001] Proc Natl Acad Sci U S A. 1984 Dec;81(24):7752-6 [6393126] Nature. 1983 Dec 8-14;306(5943):551-7 [6646234] Infect Immun. 1981 Nov;34(2):341-6 [7309227] J Bacteriol. 1979 Sep;139(3):850-8 [383697] J Clin Invest. 1991 May;87(5):1780-6 [1902492] J Infect Dis. 1990 Feb;161(2):343-7 [1967623] Nature. 1991 May 30;351(6325):371-7 [2034287] Infect Immun. 1986 Nov;54(2):529-36 [2429930] Science. 1989 Aug 25;245(4920):857-9 [2549637] J Bacteriol. 1989 Sep;171(9):4945-52 [2670900] J Bacteriol. 1987 Nov;169(11):5180-7 [2822667] Nucleic Acids Res. 1988 Aug 11;16(15):7583-600 [2970625] Proc Natl Acad Sci U S A. 1988 Oct;85(19):7109-13 [3050987] J Bacteriol. 1978 Jun;134(3):1141-56 [149110] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] Mol Microbiol. 1991 Jul;5(7):1755-67 [1943708] J Immunol. 1990 Nov 15;145(10):3162-9 [2172379] Rev Infect Dis. 1987 Sep-Oct;9 Suppl 5:S490-502 [2446368] Annu Rev Genet. 1989;23:289-310 [2694933] Infect Immun. 1988 May;56(5):1158-61 [2833443] Infect Immun. 1986 Sep;53(3):464-73 [3017862] Proc Natl Acad Sci U S A. 1987 Nov;84(21):7418-22 [3478701] Infect Immun. 1988 Jul;56(7):1748-53 [3290106] J Bacteriol. 1984 Sep;159(3):1086-9 [6090390] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cyclic AMP-independent effects of cholera toxin on B cell activation. II. Binding of ganglioside GM1 induces B cell activation. AN - 72840874; 1312102 AB - Although the physiologic function of gangliosides is unknown, evidence suggests they play a role in the regulation of cell growth. The binding of ganglioside GM1 by recombinant B subunit of cholera toxin (rCT-B) inhibited mitogen-stimulated B cell proliferation without elevating intracellular cAMP. CT-B paradoxically enhanced the expression of MHC class II (Ia) molecules and minor lymphocyte-stimulating determinants without altering the expression of some other immunologically relevant B cell surface Ag. Increased expression of Ia was not detected until 4 h after stimulation, kinetics similar to those seen when B cells are stimulated with anti-Ig antibody or IL-4, suggesting that the enhancement was not the result of redistribution of existing cell surface markers but rather the result of a new metabolic event. Both the inhibitory and stimulatory effects of CT-B could be blocked by incubation of CT-B with ganglioside GM1. Furthermore, enhancement of the CT-B-mediated effect was seen when additional ganglioside GM1 was incorporated into the B cell membrane. rCT-B with a mutation that interfered with its binding to ganglioside GM1 did not enhance Ia expression. Taken together, these results indicate that the observed effects of CT-B were most likely mediated through the binding of cell surface ganglioside GM1. CT-B-mediated stimulation of Ia expression provides a potential explanation for the previously described ability of CT-B to act as an immunoadjuvant. These results suggest that the binding of ganglioside GM1 has multiple B cell growth-regulating effects. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Francis, M L AU - Ryan, J AU - Jobling, M G AU - Holmes, R K AU - Moss, J AU - Mond, J J AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1992/04/01/ PY - 1992 DA - 1992 Apr 01 SP - 1999 EP - 2005 VL - 148 IS - 7 SN - 0022-1767, 0022-1767 KW - Histocompatibility Antigens Class II KW - 0 KW - Minor Lymphocyte Stimulatory Antigens KW - G(M1) Ganglioside KW - 37758-47-7 KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Minor Lymphocyte Stimulatory Antigens -- immunology KW - Mice KW - Histocompatibility Antigens Class II -- analysis KW - Mice, Inbred BALB C KW - Female KW - Mice, Inbred DBA KW - Lymphocyte Activation -- drug effects KW - B-Lymphocytes -- drug effects KW - G(M1) Ganglioside -- pharmacology KW - Cholera Toxin -- pharmacology KW - G(M1) Ganglioside -- metabolism KW - B-Lymphocytes -- immunology KW - Cyclic AMP -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72840874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Cyclic+AMP-independent+effects+of+cholera+toxin+on+B+cell+activation.+II.+Binding+of+ganglioside+GM1+induces+B+cell+activation.&rft.au=Francis%2C+M+L%3BRyan%2C+J%3BJobling%2C+M+G%3BHolmes%2C+R+K%3BMoss%2C+J%3BMond%2C+J+J&rft.aulast=Francis&rft.aufirst=M&rft.date=1992-04-01&rft.volume=148&rft.issue=7&rft.spage=1999&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-15 N1 - Date created - 1992-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Public Entrepreneurship and Innovation AN - 61325571; 9402984 AB - A conceptual framework of public entrepreneurship -- defined as the generation of an innovative idea, & its design & implementation into public sector practice -- is used to distinguish between public entrepreneurs & other actors in the policy process, & to clarify the differences between policy, political, executive, & bureaucratic entrepreneurs. A functionalist perspective is taken to differentiate between individual & collective entrepreneurship & generate propositions leading to a theory of public entrepreneurship. 5 Figures, 75 References. Adapted from the source document. JF - Policy Studies Review AU - Roberts, Nancy C AD - Dept Administrative Sciences Naval Postgraduate School, Monterey CA 93943 Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 55 EP - 74 VL - 11 IS - 1 KW - public entrepreneurship, innovative idea generation/design/implementation, public sector KW - Entrepreneurship KW - Policy Making KW - Public Sector KW - Technological Innovations KW - article KW - 0671: complex organization; sociology of business & entrepreneurism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61325571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Policy+Studies+Review&rft.atitle=Public+Entrepreneurship+and+Innovation&rft.au=Roberts%2C+Nancy+C&rft.aulast=Roberts&rft.aufirst=Nancy&rft.date=1992-04-01&rft.volume=11&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Policy+Studies+Review&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - PSRWD5 N1 - SubjectsTermNotLitGenreText - Entrepreneurship; Public Sector; Technological Innovations; Policy Making ER - TY - JOUR T1 - Effect of stress on oral morphine and fentanyl self-administration in rats. AN - 72945372; 1584842 AB - The effect of immobilization stress (15 min/day) or no stress on oral morphine (0.25-0.5 mg/ml) or fentanyl (5-20 micrograms/ml) self-administration was examined in rats. Animals had access to a morphine or fentanyl solution for 4 days, followed by a single-choice day of access to the opioid solution and a separate water bottle. This 5-day cycle was repeated five times for 7 h/day in home cages. Morphine consumption and preference were assessed for an additional 30 days (i.e., six more cycles) in a subgroup of subjects. Plasma corticosterone levels in the stress groups indicated that the stress manipulation was effective. Over the course of the experiment, animals in the stress groups significantly increased their preference for the opioid solutions during choice days compared to nonstress controls. Morphine preference after 55 days was twice as high in the stress group (70% morphine/30% water) in comparison to controls (34% morphine/66% water). These results indicate that stress increases oral opioid self-administration in rats. Future directions and the implications of this work are discussed. JF - Pharmacology, biochemistry, and behavior AU - Shaham, Y AU - Alvares, K AU - Nespor, S M AU - Grunberg, N E AD - Medical Psychology Department, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 615 EP - 619 VL - 41 IS - 3 SN - 0091-3057, 0091-3057 KW - Morphine KW - 76I7G6D29C KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Administration, Oral KW - Animals KW - Self Administration KW - Substance-Related Disorders -- etiology KW - Male KW - Stress, Physiological -- complications KW - Stress, Physiological -- psychology KW - Morphine -- administration & dosage KW - Fentanyl -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72945372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Effect+of+stress+on+oral+morphine+and+fentanyl+self-administration+in+rats.&rft.au=Shaham%2C+Y%3BAlvares%2C+K%3BNespor%2C+S+M%3BGrunberg%2C+N+E&rft.aulast=Shaham&rft.aufirst=Y&rft.date=1992-03-01&rft.volume=41&rft.issue=3&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-06-18 N1 - Date created - 1992-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Autoradiographic localization of 5HT1 binding sites in the medulla oblongata of the rat. AN - 72868973; 1532676 AB - Serotonin (5HT) binding sites in the medulla oblongata of the rat were localized using autoradiographic techniques with radioactive ligands that express high affinity for the 5HT1 (3H-5HT), 5HT1A (3H-80H-DPAT), or 5HT1B (125I-CYP with isoproterenol) receptor subtypes. 5HT1A sites were concentrated primarily in certain sensory regions of the medulla and in regions that contain serotonergic neurons. 5HT1B sites were diffusely distributed throughout the reticular formation and motor regions as well as being localized to certain sensory regions. A surprising finding was an association of 5HT1B binding sites with the corticospinal tract. 3H-5HT binding generally reflected the combined pattern of 5HT1A and 5HT1B sites but was also extremely dense in the choroid plexus, which exhibited virtually no 5HT1A or 5HT1B ligand binding. Presumably this binding, which was blocked by ketanserin, corresponds to 5HT1C sites. Administration of the serotonergic neurotoxin 5,7-dihydroxytryptamine reduced 5HT1A binding sites in regions of the medulla that contain serotonergic neuronal cell bodies. 5HT1B binding was not significantly altered in any area of the medulla. These studies indicate an important role for 5HT1A ligands in the processing of visceral and somatic sensory information, in regulation of certain cerebellar afferent projections, and in the regulation of serotonergic neuronal activity. 5HT1B ligands would be expected to regulate visceral and somatic efferent activity, as well as sensory information and reticular efferent activity, and might presynaptically regulate cortical inputs to the brain stem and spinal cord. JF - Synapse (New York, N.Y.) AU - Thor, K B AU - Blitz-Siebert, A AU - Helke, C J AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 185 EP - 205 VL - 10 IS - 3 SN - 0887-4476, 0887-4476 KW - Iodine Radioisotopes KW - 0 KW - Receptors, Serotonin KW - Tetrahydronaphthalenes KW - Tritium KW - 10028-17-8 KW - Serotonin KW - 333DO1RDJY KW - 8-Hydroxy-2-(di-n-propylamino)tetralin KW - 78950-78-4 KW - Iodocyanopindolol KW - 83498-72-0 KW - Pindolol KW - BJ4HF6IU1D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Tetrahydronaphthalenes -- metabolism KW - Organ Specificity KW - Autoradiography -- methods KW - Male KW - Pindolol -- metabolism KW - Brain -- metabolism KW - Serotonin -- metabolism KW - Receptors, Serotonin -- metabolism KW - Pindolol -- analogs & derivatives KW - Medulla Oblongata -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72868973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Autoradiographic+localization+of+5HT1+binding+sites+in+the+medulla+oblongata+of+the+rat.&rft.au=Thor%2C+K+B%3BBlitz-Siebert%2C+A%3BHelke%2C+C+J&rft.aulast=Thor&rft.aufirst=K&rft.date=1992-03-01&rft.volume=10&rft.issue=3&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-04 N1 - Date created - 1992-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The onset of postischemic hypoperfusion in rats is precipitous and may be controlled by local neurons. AN - 72832129; 1542903 AB - Reperfusion following transient global cerebral ischemia is characterized by an initial hyperemic phase, which precedes hypoperfusion. The pathogenesis of these flow derangements remains obscure. Our study investigates the dynamics of postischemic cerebral blood flow changes, with particular attention to the role of local neurons. We assessed local cortical blood flow continuously by laser Doppler flowmetry to permit observation of any rapid flow changes after forebrain ischemia induced by four-vessel occlusion for 20 minutes in rats. To investigate the role of local cortical neurons in the regulation of any blood flow fluctuations, five rats received intracortical microinjections of a neurotoxin (10 micrograms ibotenic acid in 1 microliter; 1.5-mm-depth parietal cortex) 24 hours before ischemia to induce selective and localized neuronal depletion in an area corresponding to the sample volume of the laser Doppler probe (1 mm3). Local cerebral blood flow was measured within the injection site and at an adjacent control site. Ischemia was followed by marked hyperemia (235 +/- 23% of control, n = 7), followed by secondary hypoperfusion (45 +/- 3% of control, n = 7). The transition from hyperemia to hypoperfusion occurred not gradually but precipitously (maximal slope of flow decay: 66 +/- 6%/min; n = 7). In ibotenic acid-injected rats, hyperemia was preserved at the injection site, but the sudden decline of blood flow was abolished (maximal slope of flow decay: 5 +/- 3%/min compared with 53 +/- 8%/min at the control site; n = 5, p less than 0.001) and no significant hypoperfusion developed (103 +/- 20% of control at 60 minutes). These data suggest that the rapid transition to cortical hypoperfusion after forebrain ischemia may be triggered locally by a neuronal mechanism but that this mechanism does not underlie the initial hyperemia. JF - Stroke AU - Frerichs, K U AU - Sirén, A L AU - Feuerstein, G Z AU - Hallenbeck, J M AD - Department of Neurology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md. Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 399 EP - 406 VL - 23 IS - 3 SN - 0039-2499, 0039-2499 KW - Ibotenic Acid KW - 2552-55-8 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Blood Pressure KW - Lasers KW - Ultrasonography KW - Male KW - Ibotenic Acid -- pharmacology KW - Brain -- physiopathology KW - Brain Ischemia -- pathology KW - Neurons -- drug effects KW - Brain -- pathology KW - Neurons -- physiology KW - Cerebrovascular Circulation KW - Brain Ischemia -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72832129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=The+onset+of+postischemic+hypoperfusion+in+rats+is+precipitous+and+may+be+controlled+by+local+neurons.&rft.au=Frerichs%2C+K+U%3BSir%C3%A9n%2C+A+L%3BFeuerstein%2C+G+Z%3BHallenbeck%2C+J+M&rft.aulast=Frerichs&rft.aufirst=K&rft.date=1992-03-01&rft.volume=23&rft.issue=3&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=00392499&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-08 N1 - Date created - 1992-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An enzymatic mutant of Shiga-like toxin II variant is a vaccine candidate for edema disease of swine. AN - 72777583; 1730480 AB - Edema disease (ED) of weanling pigs is caused by an infection with Escherichia coli that produces Shiga-like toxin II variant (SLT-IIv). Pathology identical to that caused by ED can be duplicated in pigs that are injected with less than 10 ng of purified SLT-IIv per kg of body weight. Therefore, SLT-IIv was mutated to create an immunoreactive form of the toxin that was significantly reduced in enzymatic activity. Initially, purified SLT-IIv was treated with formaldehyde which abrogated cytotoxic activity. Pigs were vaccinated with the toxoid (100 micrograms) to determine whether a toxoid was a viable vaccine candidate and whether young pigs were capable of mounting an immune response. Although the pigs developed a neutralizing antibody titer (1:128 to 1:512) 28 days postinjection, they also lost weight and developed ED lesions. The deleterious effect of the toxoid appeared to result from residual enzymatic activity or a reversion to a toxic form. An alternative method, site-directed mutagenesis, was employed to consistently reduce the enzymatic activity of SLT-IIv. Glutamate at position 167 of the mature A subunit was replaced by aspartate (E167D), and arginine at position 170 was replaced by lysine (R170K). These mutations reduced cytotoxic activity 10(4)-fold and 10-fold, respectively, while the enzymatic activities were decreased 400-fold and 5-fold, respectively. The activity of a toxin that contained both mutations (SLT-IIvE167D/R170K) closely resembled that of SLT-IIvE167D. When position 167 was replaced by glutamine (E167Q), the cytotoxic activity decreased 10(6)-fold and the enzymatic activity decreased approximately 1,500-fold. Pigs that were vaccinated with purified, mutant toxin designated SLT-IIvE167Q developed a neutralizing antibody titer of 1:512 21 days postinjection, and their tissues were free of ED lesions. These data suggest that SLT-IIvE167Q may represent an effective vaccine against ED. JF - Infection and immunity AU - Gordon, V M AU - Whipp, S C AU - Moon, H W AU - O'Brien, A D AU - Samuel, J E AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 22908. Y1 - 1992/02// PY - 1992 DA - February 1992 SP - 485 EP - 490 VL - 60 IS - 2 SN - 0019-9567, 0019-9567 KW - Bacterial Toxins KW - 0 KW - Bacterial Vaccines KW - Enterotoxins KW - Shiga Toxin 2 KW - Toxoids KW - Index Medicus KW - Swine KW - Animals, Newborn KW - Animals KW - Toxoids -- immunology KW - Mutation KW - Structure-Activity Relationship KW - Enterotoxins -- immunology KW - Bacterial Vaccines -- immunology KW - Bacterial Toxins -- immunology KW - Edema Disease of Swine -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72777583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=An+enzymatic+mutant+of+Shiga-like+toxin+II+variant+is+a+vaccine+candidate+for+edema+disease+of+swine.&rft.au=Gordon%2C+V+M%3BWhipp%2C+S+C%3BMoon%2C+H+W%3BO%27Brien%2C+A+D%3BSamuel%2C+J+E&rft.aulast=Gordon&rft.aufirst=V&rft.date=1992-02-01&rft.volume=60&rft.issue=2&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-18 N1 - Date created - 1992-02-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Infect Dis. 1985 May;151(5):775-82 [3886804] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] Mol Cell Biol. 1989 Feb;9(2):415-20 [2469000] Mol Cell Biol. 1989 Nov;9(11):5012-21 [2689871] Infect Immun. 1990 Mar;58(3):611-8 [2155181] J Bacteriol. 1990 Jun;172(6):3346-50 [2345150] Infect Immun. 1983 May;40(2):675-83 [6341244] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 [388439] J Infect Dis. 1970 Sep;122(3):170-80 [4915510] Can J Comp Med. 1974 Jan;38(1):34-43 [4272956] Infect Immun. 1991 Mar;59(3):750-7 [1705242] Vet Pathol. 1991 Jan;28(1):66-73 [1826800] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Mol Cell Biol. 1990 Dec;10(12):6257-63 [1978925] Clin Microbiol Rev. 1989 Jan;2(1):15-38 [2644022] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2568-72 [3357883] Am J Clin Pathol. 1986 Jul;86(1):108-12 [3524192] J Infect Dis. 1986 Aug;154(2):338-41 [3522760] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] Pediatr Infect Dis J. 1988 Sep;7(9):637-45 [3050858] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diagnosis and management of anaerobic infections of the head and neck. AN - 85422042; pmid-1728904 AB - Anaerobic bacteria are important pathogens in head and neck infections such as chronic otitis media, chronic sinusitis, chronic mastoiditis, head and neck abscesses, cervical adenitis, parotitis, and postoperative infection. Bacteroides sp (Bacteroides melaninogenicus group, Bacteroides oralis, and Bacteroides fragilis group), Peptostreptococcus sp, and Fusobacterium sp predominate. The observed recent increase in the number of beta-lactamase-producing strains of Bacteroides sp isolated in head and neck infections has been associated with increased failure rates of the penicillins in the management of these infections. The pathogenicity of these organisms is expressed through their ability not only to survive penicillin therapy but also to shield penicillin-susceptible pathogens from the drug. Because of these direct and indirect virulent characteristics of anaerobic bacteria, appropriate antimicrobial therapy must be directed against all pathogens in mixed infections. JF - The Annals of otology, rhinology & laryngology. Supplement AU - Brook, I AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 9 EP - 15 VL - 155 SN - 0096-8056, 0096-8056 KW - Index Medicus KW - National Library of Medicine KW - Otorhinolaryngologic Diseases -- drug therapy KW - Humans KW - Otorhinolaryngologic Diseases -- diagnosis KW - Head KW - Bacteria, Anaerobic KW - Neck KW - Bacterial Infections -- drug therapy KW - Bacterial Infections -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85422042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology+%26+laryngology.+Supplement&rft.atitle=Diagnosis+and+management+of+anaerobic+infections+of+the+head+and+neck.&rft.au=Brook%2C+I&rft.aulast=Brook&rft.aufirst=I&rft.date=1992-01-01&rft.volume=155&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology+%26+laryngology.+Supplement&rft.issn=00968056&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-02-28 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effects of aerosolized dexamethasone on acute subglottic injury. AN - 85173574; pmid-1728893 AB - Aerosolized dexamethasone was used in a two-phase study to determine the possible effects on acute subglottic injury in the ferret animal model. In phase 1, equivalent subglottic injuries were made in 10 animals by using the brush technique, and the animals were divided into two groups. The treatment group received aerosolized dexamethasone at 2, 4, and 6 hours postinjury. All animals were examined 2, 4, 6, and 24 hours after the injury. The clinical condition of each animal was evaluated and their airways were measured. The animals were then painlessly killed and the larynges were frozen, sectioned, and photographed at 1-mm intervals. A computer-linked digitizer pad was used to measure the subglottic dimensions. The results show a trend for the treated animals to have a larger subglottic airway as compared to the untreated (control) group. The phase 1 study suggests that there may be an improvement in the subglottic airway when treated acutely with aerosolized dexamethasone. In phase 2, 20 additional animals were studied by using the same methods of injury and treatment as in phase 1. The subglottic airways of these animals were evaluated with histomorphometric analysis on fixed histologic sections. A statistically significant difference was found between the subglottic airways of the treated and untreated animals favoring treatment with aerosolized dexamethasone. Aerosolized dexamethasone appears to be beneficial in preserving the subglottic airway after injury, possibly secondary to decreasing the edema associated with injury. JF - The Annals of Otology, Rhinology, and Laryngology AU - Kryzer, T C AU - Gonzalez, C AU - Burgess, L P AD - Department of Surgery, Uniformed Services University of the Health Sciences, Washington, DC. PY - 1992 SP - 95 EP - 99 VL - 101 IS - 1 SN - 0003-4894, 0003-4894 KW - Acute Disease KW - Dexamethasone KW - Laryngeal Edema KW - Research Support, Non-U.S. Gov't KW - Animals KW - Glottis KW - Ferrets KW - Larynx KW - Laryngoscopy KW - Administration, Inhalation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85173574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Effects+of+aerosolized+dexamethasone+on+acute+subglottic+injury.&rft.au=Kryzer%2C+T+C%3BGonzalez%2C+C%3BBurgess%2C+L+P&rft.aulast=Kryzer&rft.aufirst=T&rft.date=1992-01-01&rft.volume=101&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The use of human drug discrimination studies in medication development. AN - 73338866; 1435976 JF - NIDA research monograph AU - Johanson, C E AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1992 PY - 1992 DA - 1992 SP - 180 EP - 184 VL - 119 SN - 1046-9516, 1046-9516 KW - Index Medicus KW - Humans KW - Discrimination (Psychology) -- drug effects KW - Substance-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73338866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=The+use+of+human+drug+discrimination+studies+in+medication+development.&rft.au=Johanson%2C+C+E&rft.aulast=Johanson&rft.aufirst=C&rft.date=1992-01-01&rft.volume=119&rft.issue=&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-07 N1 - Date created - 1992-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Resolution of terfenadine enantiomers by beta-cyclodextrin chiral stationary phase high-performance liquid chromatography. AN - 73213877; 1389964 AB - Enantiomers of terfenadine were resolved by high-performance liquid chromatography (HPLC) using a chiral stationary phase (CSP) column packed with beta-cyclodextrin (beta-CD) covalently bound to silica. Separation was achieved in both the reverse phase and normal phase modes. Resolution of enantiomers was confirmed by ultraviolet-visible absorption, circular dichroism, and mass spectral analysis. JF - Chirality AU - Weems, H AU - Zamani, K AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, Maryland 20814-4799. Y1 - 1992 PY - 1992 DA - 1992 SP - 268 EP - 272 VL - 4 IS - 4 SN - 0899-0042, 0899-0042 KW - Cyclodextrins KW - 0 KW - beta-Cyclodextrins KW - Terfenadine KW - 7BA5G9Y06Q KW - betadex KW - JV039JZZ3A KW - Index Medicus KW - Stereoisomerism KW - Hydrogen-Ion Concentration KW - Spectrophotometry, Ultraviolet KW - Chromatography, High Pressure Liquid KW - Terfenadine -- metabolism KW - Terfenadine -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73213877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chirality&rft.atitle=Resolution+of+terfenadine+enantiomers+by+beta-cyclodextrin+chiral+stationary+phase+high-performance+liquid+chromatography.&rft.au=Weems%2C+H%3BZamani%2C+K&rft.aulast=Weems&rft.aufirst=H&rft.date=1992-01-01&rft.volume=4&rft.issue=4&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Chirality&rft.issn=08990042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-11-25 N1 - Date created - 1992-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mercury clearance from human plasma during in vitro dialysis: screening systems for chelating agents. AN - 73151951; 1512815 AB - Two in vitro systems were evaluated as potential screening methods for determining the most effective chelating agents for use in patients with inorganic mercury poisoning undergoing hemodialysis. The first system consisted of an in vitro clinical hemodialysis unit and the second system consisted of an in vitro equilibrium dialysis procedure. Both systems utilized pooled human plasma. Ten chelating agents were evaluated in these systems to determine their ability to enhance mercury clearance from human plasma. In the absence of chelators, plasma clearance of mercury was negligible. Of the chelating agents tested, 2,3-dimercaptopropanolol, which enhances biliary and fecal excretion of mercury poisoning, and dithiothreitol did not enhance mercury clearance at 90 min in the hemodialysis system. N-acetylcysteine appeared to be the most effective chelating agent of those tested in the hemodialysis system. N-acetylcysteine produced a 73% decrease in perfusate mercury concentration at 90 min. The results of equilibrium dialysis mirrored those of the hemodialysis in that N-acetylcysteine significantly enhanced mercury transfer across the dialysis membrane into the dialysate whereas dithiothreitol did not. If in vivo experiments confirm the present findings, then in vitro dialysis from pooled human plasma either using a standard clinical hemodialyzer or equilibrium dialysis system will be useful screening tools. Our results suggest that equilibrium dialysis may be a convenient and cost effective method to screen potential chelating agents as complementary to hemodialysis for the treatment of inorganic mercury poisoning. JF - Journal of toxicology. Clinical toxicology AU - Ferguson, C L AU - Cantilena, L R AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1992 PY - 1992 DA - 1992 SP - 423 EP - 441 VL - 30 IS - 3 SN - 0731-3810, 0731-3810 KW - Chelating Agents KW - 0 KW - Mercuric Chloride KW - 53GH7MZT1R KW - Abridged Index Medicus KW - Index Medicus KW - Dialysis KW - Humans KW - Spectrophotometry, Atomic KW - Renal Dialysis KW - Mercuric Chloride -- pharmacokinetics KW - Plasma -- metabolism KW - Chelating Agents -- metabolism KW - Drug Evaluation, Preclinical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73151951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology.+Clinical+toxicology&rft.atitle=Mercury+clearance+from+human+plasma+during+in+vitro+dialysis%3A+screening+systems+for+chelating+agents.&rft.au=Ferguson%2C+C+L%3BCantilena%2C+L+R&rft.aulast=Ferguson&rft.aufirst=C&rft.date=1992-01-01&rft.volume=30&rft.issue=3&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology.+Clinical+toxicology&rft.issn=07313810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-29 N1 - Date created - 1992-09-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Toxicol Clin Toxicol. 1993;31(2):365-6 [8492350] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Retroperitoneal fibrosis following radiotherapy for stage I testicular seminoma. AN - 72729186; 1729501 AB - Retroperitoneal fibrosis, proved by surgical exploration and pathology, was discovered in a patient 13 years after 3,000 rad external beam cobalt retroperitoneal radiation therapy for stage I testicular seminoma. Ureteral obstruction resulted in the loss of 1 kidney, necessitating ipsilateral nephrectomy and contralateral ureterolysis. To my knowledge this is the first reported case of retroperitoneal fibrosis occurring after radiotherapy for testicular cancer. JF - The Journal of urology AU - Moul, J W AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 124 EP - 126 VL - 147 IS - 1 SN - 0022-5347, 0022-5347 KW - Abridged Index Medicus KW - Index Medicus KW - Hydronephrosis -- etiology KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Tomography, X-Ray Computed KW - Male KW - Hydronephrosis -- diagnostic imaging KW - Testicular Neoplasms -- radiotherapy KW - Retroperitoneal Fibrosis -- etiology KW - Dysgerminoma -- radiotherapy KW - Retroperitoneal Fibrosis -- diagnostic imaging KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72729186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Retroperitoneal+fibrosis+following+radiotherapy+for+stage+I+testicular+seminoma.&rft.au=Moul%2C+J+W&rft.aulast=Moul&rft.aufirst=J&rft.date=1992-01-01&rft.volume=147&rft.issue=1&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-10 N1 - Date created - 1992-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Molecular genetic analysis of ganglioside GD1b-binding activity of Escherichia coli type IIa heat-labile enterotoxin by use of random and site-directed mutagenesis. AN - 72722680; 1729197 AB - Mutagenesis of the B-subunit gene of Escherichia coli heat-labile enterotoxin LT-IIa was performed in vitro with sodium bisulfite. Mutants were screened initially by radial passive immune hemolysis assays for loss of binding to erythrocytes. Mutant B polypeptides were characterized for immunoreactivity; for binding to gangliosides GD1b, GD1a, and GM1; for formation of holotoxin; and for biological activity. Mutant alleles that determined altered binding specificities were sequenced. Three such mutant alleles encoded Thr-to-Ile substitutions at residues 13, 14, and 34 in the mature B polypeptide of LT-IIa. Each mutant protein failed to bind to ganglioside GD1b, although the Ile-14 mutant retained the ability to bind to ganglioside GM1. Site-specific mutagenesis was used to construct mutants with various amino acid substitutions at residue 13, 14, or 34. Only those mutant proteins with Ser substituted for Thr at position 13, 14, or 34 retained the ability to bind to ganglioside GD1b, thereby suggesting a role for the hydroxyl group of Thr or Ser in ganglioside GD1b binding. JF - Infection and immunity AU - Connell, T D AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 63 EP - 70 VL - 60 IS - 1 SN - 0019-9567, 0019-9567 KW - Bacterial Toxins KW - 0 KW - Enterotoxins KW - Escherichia coli Proteins KW - Gangliosides KW - Glycosides KW - Oligonucleotide Probes KW - Sulfites KW - Triterpenes KW - heat-labile enterotoxin, E coli KW - ganglioside, GD1a KW - 12707-58-3 KW - ganglioside, GD1b KW - 19553-76-5 KW - stichoposide KW - 37341-37-0 KW - G(M1) Ganglioside KW - 37758-47-7 KW - hydrogen sulfite KW - OJ9787WBLU KW - Index Medicus KW - Animals KW - Mutagenesis -- drug effects KW - Oligonucleotide Probes -- genetics KW - Biological Assay KW - Triterpenes -- metabolism KW - Amino Acid Sequence KW - Plasmids KW - Radioimmunoassay KW - Glycosides -- metabolism KW - In Vitro Techniques KW - Hemolysis KW - Molecular Sequence Data KW - Enterotoxins -- physiology KW - Bacterial Toxins -- metabolism KW - Escherichia coli -- pathogenicity KW - G(M1) Ganglioside -- metabolism KW - Gangliosides -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72722680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Molecular+genetic+analysis+of+ganglioside+GD1b-binding+activity+of+Escherichia+coli+type+IIa+heat-labile+enterotoxin+by+use+of+random+and+site-directed+mutagenesis.&rft.au=Connell%2C+T+D%3BHolmes%2C+R+K&rft.aulast=Connell&rft.aufirst=T&rft.date=1992-01-01&rft.volume=60&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-12 N1 - Date created - 1992-02-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Microbiol. 1991 Jul;5(7):1755-67 [1943708] Nature. 1991 May 30;351(6325):371-7 [2034287] Microb Pathog. 1990 Nov;9(5):315-29 [2099384] Biochem J. 1986 Sep 1;238(2):313-22 [3541910] Proc Natl Acad Sci U S A. 1988 Oct;85(19):7109-13 [3050987] Gene. 1986;45(3):333-8 [3026919] J Biol Chem. 1985 Oct 15;260(23):12528-34 [2413025] J Bacteriol. 1987 Nov;169(11):5180-7 [2822667] Infect Immun. 1986 Sep;53(3):464-73 [3017862] Rev Infect Dis. 1987 Sep-Oct;9 Suppl 5:S490-502 [2446368] Infect Immun. 1986 Nov;54(2):529-36 [2429930] J Bacteriol. 1989 Sep;171(9):4945-52 [2670900] Gene. 1989 Feb 20;75(2):243-51 [2653963] Infect Immun. 1989 Apr;57(4):1165-9 [2925244] Infect Immun. 1984 Dec;46(3):759-64 [6209224] Microbiol Rev. 1984 Sep;48(3):199-221 [6436655] Methods Enzymol. 1987;154:415-30 [3323815] Infect Immun. 1986 Nov;54(2):587-9 [3533784] J Bacteriol. 1986 Feb;165(2):348-52 [3511028] J Biol Chem. 1985 Jul 15;260(14):8552-8 [3924916] Nature. 1983 Dec 8-14;306(5943):551-7 [6646234] J Biol Chem. 1981 Jun 10;256(11):5481-8 [6787042] Infect Immun. 1983 Dec;42(3):914-23 [6196297] J Biol Chem. 1984 Apr 25;259(8):5037-44 [6325417] FEBS Lett. 1984 Apr 24;169(2):241-6 [6325242] Infect Immun. 1984 Mar;43(3):1027-32 [6365779] Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 [6546423] Infect Immun. 1981 Sep;33(3):677-82 [7026442] Infect Immun. 1981 Jun;32(3):1034-44 [7019086] Nature. 1980 Dec 4;288(5790):499-501 [7003397] Infect Immun. 1981 Nov;34(2):341-6 [7309227] Biochem Biophys Res Commun. 1979 Dec 14;91(3):1005-10 [118748] J Clin Microbiol. 1978 Aug;8(2):252-5 [359590] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] J Immunol. 1974 Jul;113(1):145-50 [4208916] J Immunol. 1966 Mar;96(3):440-9 [4956587] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Latrodectism: bite of the black widow spider. AN - 72722358; 1728088 AB - Latrodectism, the clinical syndrome that follows envenomation by the black widow spider, may easily be confused with more common conditions. Acute manifestations are characterized by agonizing pain and muscle spasm. Prolonged symptoms, primarily related to neurologic dysfunction, may occur. Familiarity with the manifestations of latrodectism is the key to diagnosis. Family physicians should consider latrodectism in patients presenting with severe pain and muscle cramps, particularly if the setting and history are consistent with a possible spider bite. Optimal therapy remains controversial. Early use of specific antivenin in severely envenomated patients may prevent the development of lingering symptoms, usually related to neurologic dysfunction. JF - American family physician AU - Miller, T A AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1992/01// PY - 1992 DA - January 1992 SP - 181 EP - 187 VL - 45 IS - 1 SN - 0002-838X, 0002-838X KW - Antivenins KW - 0 KW - Muscle Relaxants, Central KW - Calcium Gluconate KW - SQE6VB453K KW - Abridged Index Medicus KW - Index Medicus KW - Clinical Protocols -- standards KW - Animals KW - Diagnosis, Differential KW - Humans KW - Muscle Relaxants, Central -- therapeutic use KW - Adult KW - Calcium Gluconate -- therapeutic use KW - Female KW - Antivenins -- therapeutic use KW - Spider Bites -- physiopathology KW - Spider Bites -- diagnosis KW - Black Widow Spider KW - Family Practice -- methods KW - Spider Bites -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72722358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=Latrodectism%3A+bite+of+the+black+widow+spider.&rft.au=Miller%2C+T+A&rft.aulast=Miller&rft.aufirst=T&rft.date=1992-01-01&rft.volume=45&rft.issue=1&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-30 N1 - Date created - 1992-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Current patterns over the shelf and slope adjacent to the Gulf of the Farallones; executive summary AN - 50363458; 1993-004177 JF - Open-File Report - U. S. Geological Survey AU - Noble, Marlene A AU - Ramp, Steven R AU - Kinoshita, Kaye L Y1 - 1992 PY - 1992 DA - 1992 SP - 26 PB - U. S. Geological Survey, Reston, VA SN - 0196-1497, 0196-1497 KW - United States KW - East Pacific KW - currents KW - Gulf of Farallones KW - ocean circulation KW - continental slope KW - Northeast Pacific KW - site exploration KW - waste disposal sites KW - ocean currents KW - dredged materials KW - North American Pacific KW - California KW - San Francisco Bay KW - North Pacific KW - Pacific Ocean KW - continental shelf KW - waste disposal KW - USGS KW - 22:Environmental geology KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50363458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open-File+Report+-+U.+S.+Geological+Survey&rft.atitle=Current+patterns+over+the+shelf+and+slope+adjacent+to+the+Gulf+of+the+Farallones%3B+executive+summary&rft.au=Noble%2C+Marlene+A%3BRamp%2C+Steven+R%3BKinoshita%2C+Kaye+L&rft.aulast=Noble&rft.aufirst=Marlene&rft.date=1992-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Open-File+Report+-+U.+S.+Geological+Survey&rft.issn=01961497&rft_id=info:doi/ L2 - http://walrus.wr.usgs.gov/reports/ofr92-382/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 39 N1 - Availability - U. S. Geol. Surv., Denver, CO, United States N1 - PubXState - VA N1 - Document feature - illus. incl. 1 table, sketch maps N1 - Last updated - 2016-10-25 N1 - CODEN - XGROAG N1 - SubjectsTermNotLitGenreText - California; continental shelf; continental slope; currents; dredged materials; East Pacific; Gulf of Farallones; North American Pacific; North Pacific; Northeast Pacific; ocean circulation; ocean currents; Pacific Ocean; San Francisco Bay; site exploration; United States; USGS; waste disposal; waste disposal sites ER - TY - JOUR T1 - Fire temperature monitoring during experimental burns at Indiana Dunes National Lakeshore. AN - 16353194; 2850750 AB - Fire temperature was measured during several prescribed fires in a mosaic of prairies and oak woods within the Indiana Dunes National Lakeshore using temperature sensitive paints on aluminum tags and mica sheets. Aboveground temperatures were highest in the prairies, often exceeding the melting point of the aluminum tags, and lower in the oak woods. Belowground temperatures, measured by painted mica sheets, were higher in the oak woods than in the prairies. Tree crown mortality was correlated with fire temperature and tree diameter. The results demonstrate high spatial variability in temperature during single burns in this mosaic of plant communities. This variation results from differences in fuel characteristics and the pattern of fire spread. While each community type had its own distinctive temperature profile, temperatures were highly variable among plots within the same community type. JF - Natural Areas Journal AU - Cole, K L AU - Klick, K F AU - Pavlovic, N B AD - NPS-CPSU, Dep. Forest Resour., 115 Green Hall, Univ. Minnesota, St. Paul, MN 55108, USA Y1 - 1992 PY - 1992 DA - 1992 SP - 177 EP - 183 VL - 12 IS - 4 SN - 0885-8608, 0885-8608 KW - temperature KW - USA, Indiana, Dunes Natl. Lakeshore KW - Ecology Abstracts KW - fires KW - spatial distribution KW - monitoring KW - prairies KW - methodology KW - D 04700:Management KW - D 04001:Methodology - general UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16353194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Natural+Areas+Journal&rft.atitle=Fire+temperature+monitoring+during+experimental+burns+at+Indiana+Dunes+National+Lakeshore.&rft.au=Cole%2C+K+L%3BKlick%2C+K+F%3BPavlovic%2C+N+B&rft.aulast=Cole&rft.aufirst=K&rft.date=1992-01-01&rft.volume=12&rft.issue=4&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Natural+Areas+Journal&rft.issn=08858608&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - fires; monitoring; prairies; spatial distribution; methodology ER - TY - JOUR T1 - Echinostomiasis--a snail-borne intestinal trematode zoonosis. AN - 72763218; 1822887 AB - Numerous echinostome trematodes are found in the intestines of birds and mammals throughout the world, and echinostomiasis in humans has been attributed to approximately 16 different species. In humans it is usually regarded as a rare intestinal parasite of little clinical importance except in heavy infections. Diagnosis of echinostomiasis is made by identification of eggs during fecal examination; however, speciation of echinostomes requires morphological study of adult worms following anthelminthic treatment. The complex life cycles of echinostomes are all linked to freshwater habitats. A mammalian or avian definitive host, one or two molluscan hosts, and one or two freshwater stages are usually required to complete the life cycle. In addition, amphibians and fish have been implicated in the transmission of some species. Prevention of human cases is dependent on eating habits, since raw or insufficiently cooked molluses, and to a lesser extent fish and amphibians, are sources of infection for humans. Human cases have been effectively, albeit accidentally, controlled by the introduction of fish which prey on the larval stages of the essential molluscan hosts. JF - The Southeast Asian journal of tropical medicine and public health AU - Carney, W P AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 206 EP - 211 VL - 22 Suppl SN - 0125-1562, 0125-1562 KW - Index Medicus KW - Far East -- epidemiology KW - Animals KW - Echinostoma -- growth & development KW - Humans KW - Food Parasitology KW - Asia, Southeastern -- epidemiology KW - Echinostomiasis -- prevention & control KW - Zoonoses KW - Echinostomiasis -- drug therapy KW - Echinostomiasis -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72763218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.atitle=Echinostomiasis--a+snail-borne+intestinal+trematode+zoonosis.&rft.au=Carney%2C+W+P&rft.aulast=Carney&rft.aufirst=W&rft.date=1991-12-01&rft.volume=22+Suppl&rft.issue=&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.issn=01251562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-10 N1 - Date created - 1992-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cardiovascular effects of platelet-activating factor. AN - 72750744; 1819712 AB - Sudden release of platelet-activating factor (PAF) into the circulation can cause hypotension, tachycardia, and circulatory collapse. To further examine this response, we performed detailed studies of cardiovascular function after PAF administration to young domestic pigs and newborn piglets. Our results indicate that circulatory dysfunction after PAF reflects severe constriction of pulmonary resistance vessels and consequent acute right ventricular failure. Although PAF-induced coronary artery constriction and contractile depression may be complicating problems, left ventricular underperfusion and dysfunction after PAF are mainly the result of systemic arterial hypotension and diminished left ventricular filling. The adverse hemodynamic effects of PAF are accompanied by substantial release of thromboxane A2 (TxA2). These effects are mimicked by the TxA2 agonist U-46619 and partially blocked by specific and nonspecific inhibitors of TxA2 synthesis (OKY-046 and indomethacin). Even more potent blockade of PAF action is exerted by the TxA2 receptor blocker, SQ 29,548. Taken together, these findings indicate that severe pulmonary vascular constriction and hemodynamic collapse soon after intravenous PAF are at least partially mediated by PAF-induced TxA2 release. Tachyphylaxis to PAF influence has been observed in studies of leukocyte and platelet function. We hypothesized that tachyphylaxis to PAF might also occur in our studies of constrictor responses in pulmonary vessels. Recently, we have examined the capacity of PAF to produce sustained pulmonary vasoconstriction in open-chested, anesthetized newborn piglets. Infusions sufficient to produce 100% increase in mean pulmonary artery pressure after 3 min showed no loss of efficacy when sustained for 30 min.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Lipids AU - Goldstein, R E AU - Feuerstein, G Z AU - Bradley, L M AU - Stambouly, J J AU - Laurindo, F R AU - Davenport, N J AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1250 EP - 1256 VL - 26 IS - 12 SN - 0024-4201, 0024-4201 KW - Platelet Activating Factor KW - 0 KW - Thromboxane A2 KW - 57576-52-0 KW - Index Medicus KW - Swine KW - Animals KW - Cardiovascular Physiological Phenomena KW - Thromboxane A2 -- antagonists & inhibitors KW - Hemodynamics -- drug effects KW - Platelet Activating Factor -- pharmacology KW - Platelet Activating Factor -- toxicity KW - Cardiovascular System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72750744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lipids&rft.atitle=Cardiovascular+effects+of+platelet-activating+factor.&rft.au=Goldstein%2C+R+E%3BFeuerstein%2C+G+Z%3BBradley%2C+L+M%3BStambouly%2C+J+J%3BLaurindo%2C+F+R%3BDavenport%2C+N+J&rft.aulast=Goldstein&rft.aufirst=R&rft.date=1991-12-01&rft.volume=26&rft.issue=12&rft.spage=1250&rft.isbn=&rft.btitle=&rft.title=Lipids&rft.issn=00244201&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-07-30 N1 - Date created - 1992-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Imipramine as a discriminative stimulus. AN - 72577793; 1762063 AB - The tricyclic antidepressant imipramine was established as a discriminative stimulus in pigeons at two doses (3.0 or 5.6 mg/kg). Because imipramine has multiple effects on different neurotransmitter systems, a range of compounds from several pharmacological classes were tested for substitution. The tricyclic antidepressants desipramine, amitriptyline and doxepin, all of which block serotonin (5-HT) and norepinephrine (NE) reuptake, resulted in imipramine-key responding. The psychomotor stimulants cocaine and d-amphetamine also occasioned responding on the imipramine key, as did the NE reuptake inhibitor tomoxetine; nomifensine, which blocks the reuptake of both NE and dopamine (DA), also resulted in responding on the key correlated with imipramine injections. Bupropion, a DA reuptake inhibitor, resulted in drug key responding but substitution did not occur with another DA uptake inhibitor GBR 12909. The alpha-2 agonist clonidine, the 5-HT2 antagonist ritanserin or the 5-HT reuptake inhibitor fluoxetine also did not occasion drug-key responding. Drug-appropriate responding occurred in pigeons trained at the lower dose of imipramine with the 5-HT1A compounds 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide and gepirone; partial substitution occurred in pigeons trained with the higher dose of imipramine. Substitution for the imipramine stimulus by gepirone, an antidepressant with actions mediated by the 5-HT1A receptor, as well as with 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, suggests that imipramine may have effects at this receptor site and confirms reports that compounds active at this receptor may have antidepressant activity. This appears to be the first report of the successful, long-term establishment of imipramine as a discriminative stimulus without the development of toxicity.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Zhang, L AU - Barrett, J E AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 1088 EP - 1093 VL - 259 IS - 3 SN - 0022-3565, 0022-3565 KW - Bupropion KW - 01ZG3TPX31 KW - Amitriptyline KW - 1806D8D52K KW - Amphetamine KW - CK833KGX7E KW - Cocaine KW - I5Y540LHVR KW - Imipramine KW - OGG85SX4E4 KW - Index Medicus KW - Animals KW - Amitriptyline -- pharmacology KW - Dose-Response Relationship, Drug KW - Columbidae KW - Cocaine -- pharmacology KW - Amphetamine -- pharmacology KW - Bupropion -- pharmacology KW - Discrimination Learning -- drug effects KW - Imipramine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72577793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Imipramine+as+a+discriminative+stimulus.&rft.au=Zhang%2C+L%3BBarrett%2C+J+E&rft.aulast=Zhang&rft.aufirst=L&rft.date=1991-12-01&rft.volume=259&rft.issue=3&rft.spage=1088&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-07 N1 - Date created - 1992-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Anesthesia for Dupuytren's contracture. AN - 72616350; 1769991 AB - Despite the potential complications of brachial plexus blockade, it remains a reliable and safe form of anesthesia for surgery of the upper extremity. The site of the surgery dictates which of the four approaches to the brachial plexus should be used. When the choice matches the site of surgery, the blocks should be successful in approximately 80% of cases. When supplemented with an additional peripheral block, the success rate is greater than 90% using the axillary and supraclavicular approaches. The duration of the blocks varies from 1 to 12 hours, depending on the choice of anesthetic agent. The addition of epinephrine to the anesthetic agent decreases the rate of tissue uptake of the drug, thereby both lengthening the duration of the block and decreasing the toxicity of the agent. Alkalinizing lidocaine with sodium bicarbonate decreases the latency time and increases the intensity and spread of the block. Surgeons should be aware of the advantages and capabilities of regional anesthesia and should discuss anesthesia options with patients and anesthesiologists. JF - Hand clinics AU - Gandy, C L AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 695 EP - 704; discussion 705-6 VL - 7 IS - 4 SN - 0749-0712, 0749-0712 KW - Lidocaine KW - 98PI200987 KW - Bupivacaine KW - Y8335394RO KW - Index Medicus KW - Humans KW - Brachial Plexus KW - Anesthesia, General KW - Nerve Block -- adverse effects KW - Nerve Block -- methods KW - Nerve Block -- contraindications KW - Dupuytren Contracture -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72616350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hand+clinics&rft.atitle=Anesthesia+for+Dupuytren%27s+contracture.&rft.au=Gandy%2C+C+L&rft.aulast=Gandy&rft.aufirst=C&rft.date=1991-11-01&rft.volume=7&rft.issue=4&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Hand+clinics&rft.issn=07490712&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-26 N1 - Date created - 1992-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of a defective diphtheria toxin repressor (dtxR) allele and analysis of dtxR transcription in wild-type and mutant strains of Corynebacterium diphtheriae. AN - 72442440; 1718867 AB - The production of diphtheria toxin and siderophore by the Corynebacterium diphtheriae regulatory mutant C7(beta)hm723 is resistant to the inhibitory effects of iron, and the mutant strain is defective for function of the regulatory gene dtxR. A 2.8-kb HindIII fragment carrying the C7(beta)hm723 dtxR allele was cloned and characterized in Escherichia coli. The restriction endonuclease maps of the 2.8-kb HindIII fragment from C7(beta)hm723 and the corresponding fragment from wild-type C. diphtheriae C7 were identical. RNA dot blot analysis with total RNA isolated from wild-type C. diphtheriae C7 and C7(beta)hm723 indicated that the dtxR gene was transcribed at very low but equivalent levels in both strains and was not regulated by iron. beta-Galactosidase synthesis from a tox-lacZ translational fusion construct in E. coli in high-iron medium was not repressed by the C7(beta)hm723dtxR allele, but was strongly repressed by the wild-type dtxR gene. The 28- to 29-kDa polypeptide expressed from the mutant dtxR allele in E. coli had the same electrophoretic mobility as the wild-type dtxR gene product in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The nucleotide sequence of the coding region and the 5' upstream region of the C7(beta)hm723 dtxR allele was determined and compared with the wild-type nucleotide sequence. The dtxR allele from C7(beta)hm723 contained a single-base change located 140 nucleotides from the 5' start of the gene, which resulted in replacement of arginine in the wild-type sequence by histidine in the mutant protein. These data demonstrate that C7(beta)hm723 expresses a mutant DtxR repressor protein that is severely defective in repressor activity. JF - Infection and immunity AU - Schmitt, M P AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 3903 EP - 3908 VL - 59 IS - 11 SN - 0019-9567, 0019-9567 KW - dtxR KW - DNA, Bacterial KW - 0 KW - Diphtheria Toxin KW - RNA, Bacterial KW - RNA, Messenger KW - Recombinant Fusion Proteins KW - Repressor Proteins KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Gene Expression Regulation, Bacterial KW - Iron -- physiology KW - Transcription, Genetic KW - Amino Acid Sequence KW - RNA, Bacterial -- genetics KW - RNA, Messenger -- genetics KW - Molecular Weight KW - Base Sequence KW - Blotting, Southern KW - DNA, Bacterial -- genetics KW - Restriction Mapping KW - Molecular Sequence Data KW - Genes, Bacterial KW - Corynebacterium diphtheriae -- genetics KW - Diphtheria Toxin -- genetics KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72442440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Characterization+of+a+defective+diphtheria+toxin+repressor+%28dtxR%29+allele+and+analysis+of+dtxR+transcription+in+wild-type+and+mutant+strains+of+Corynebacterium+diphtheriae.&rft.au=Schmitt%2C+M+P%3BHolmes%2C+R+K&rft.aulast=Schmitt&rft.aufirst=M&rft.date=1991-11-01&rft.volume=59&rft.issue=11&rft.spage=3903&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-27 N1 - Date created - 1991-11-27 N1 - Date revised - 2017-01-13 N1 - Gene symbol - dtxR N1 - SuppNotes - Cited By: J Bacteriol. 1983 Apr;154(1):245-52 [6403502] Antimicrob Agents Chemother. 1980 Nov;18(5):814-21 [6255866] Appl Environ Microbiol. 1981 Dec;42(6):1130-1 [6797351] J Virol. 1981 Mar;37(3):946-54 [6785450] J Virol. 1981 Mar;37(3):936-45 [6785449] Mol Gen Genet. 1981;182(2):288-92 [7026976] Annu Rev Biochem. 1977;46:69-94 [20040] Infect Immun. 1979 Dec;26(3):1065-70 [118927] J Bacteriol. 1978 Aug;135(2):511-6 [98519] Infect Immun. 1977 Oct;18(1):203-9 [409685] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Proc Natl Acad Sci U S A. 1974 Jan;71(1):11-5 [4204202] J Virol. 1969 Jun;3(6):586-98 [4978942] J Virol. 1976 Apr;18(1):235-44 [815566] Infect Immun. 1973 Mar;7(3):445-56 [16558077] Microb Pathog. 1990 Oct;9(4):267-73 [2151460] Infect Immun. 1991 Jun;59(6):1899-904 [1828057] J Bacteriol. 1987 Oct;169(10):4759-64 [3308853] Gene. 1988 Oct 15;70(1):191-7 [2853689] Mol Gen Genet. 1987 Nov;210(1):135-9 [3323834] Microbiol Rev. 1987 Dec;51(4):509-18 [2963952] Proc Natl Acad Sci U S A. 1985 Feb;82(4):1074-8 [3156376] Eur J Biochem. 1988 May 2;173(3):537-46 [2836193] J Bacteriol. 1988 Oct;170(10):4477-83 [3139628] Infect Immun. 1988 Sep;56(9):2430-6 [3044999] J Bacteriol. 1985 Sep;163(3):1114-9 [2411714] J Hyg (Lond). 1984 Dec;93(3):405-17 [6439780] Proc Natl Acad Sci U S A. 1990 Aug;87(15):5968-72 [2116013] FEMS Microbiol Lett. 1990 Jan 1;54(1-3):119-23 [2108894] Anal Biochem. 1981 Jun;114(1):193-7 [6269464] J Mol Biol. 1983 Jun 5;166(4):557-80 [6345791] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Interferon in combination with antitumourigenic phenyl derivatives: potentiation of IFN alpha activity in-vitro. AN - 72167051; 1931716 AB - Any attempt to eradicate the heterogeneous cell population of a tumour mass would require the use of appropriate combination treatment protocols. The antitumour effects of interferon alpha (IFN alpha) in combination with AS2-1, the hydrolysis product of 3-phenylacetyl-amino-2,6-piperidinedione, were examined using several human tumour cell lines as a model. These included the malignant melanoma A375, adenocarcinoma of the prostate PC3 (hormone-insensitive bone metastasis), and the erythroleukaemia line K562. AS2-1 suppressed tumour growth through non-toxic mechanisms, with 1 mg/ml causing approximately 50% inhibition of the melanoma and prostate tumour cell proliferation. By contrast, primary normal human skin fibroblasts were significantly less sensitive to the antiproliferative effect of AS2-1. Suppression of tumour growth was seen also with AS2-1 treatment of the erythroleukaemia K562; in these cultures the drug also induced dose-dependent differentiation, as indicated by the increased haemoglobin production. Interestingly, addition of low doses of IFN alpha markedly enhanced the antitumour and differentiating effects observed with AS2-1. Treatment with 200-300 IU/ml of IFN (which caused about 20% inhibition of growth) together with 1 mg/ml of AS2-1 resulted in over 80% inhibition of the melanoma and prostate cancer cell proliferation, suggesting a synergistic activity of the two agents. This was substantiated by quantitative analysis of the differentiation induced in K562 erythroleukaemia. It appears, therefore, that IFN alpha and AS2-1 may act through synergistic mechanisms to effectively inhibit tumour growth and promote differentiation in a variety of human malignant cell lines. JF - British journal of haematology AU - Samid, D AU - Yeh, T J AU - Shack, S AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 81 EP - 83 VL - 79 Suppl 1 SN - 0007-1048, 0007-1048 KW - Interferon-alpha KW - 0 KW - Phenylacetates KW - Glutamine KW - 0RH81L854J KW - phenylacetylglutamine KW - 28047-15-6 KW - phenylacetic acid KW - ER5I1W795A KW - Index Medicus KW - Humans KW - In Vitro Techniques KW - Cell Division -- drug effects KW - Drug Synergism KW - Cell Line KW - Interferon-alpha -- pharmacology KW - Glutamine -- pharmacology KW - Glutamine -- analogs & derivatives KW - Phenylacetates -- pharmacology KW - Tumor Cells, Cultured -- drug effects KW - Tumor Cells, Cultured -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72167051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=Interferon+in+combination+with+antitumourigenic+phenyl+derivatives%3A+potentiation+of+IFN+alpha+activity+in-vitro.&rft.au=Samid%2C+D%3BYeh%2C+T+J%3BShack%2C+S&rft.aulast=Samid&rft.aufirst=D&rft.date=1991-10-01&rft.volume=79+Suppl+1&rft.issue=&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=00071048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-19 N1 - Date created - 1991-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of bufalin on norepinephrine turnover in canine saphenous vein. AN - 72135814; 1655648 AB - Abundant experimental data suggest that an endogenous digitalislike factor is responsible for some essential hypertension. Some forms of hypertension have also been associated with increased levels of catecholamines. We therefore designed experiments to investigate the role of digitalislike factors in the regulation of norepinephrine turnover in the neurovascular junction. We chose bufalin, an amphibian-derived compound that shares many of the physiological properties postulated as characteristic of digitalislike compounds, as a model of the mammalian compound. In vitro experiments in canine saphenous veins showed that, in addition to inhibiting norepinephrine uptake, bufalin increased norepinephrine overflow by an amount larger than could be explained solely by uptake inhibition. The effect of bufalin on norepinephrine overflow is inhibited by tetrodotoxin, which suggests a dependence of this response on Na+ influx through the neuronal membranes. We propose that Na+,K(+)-ATPase inhibition resulting in neuronal depolarization is responsible for the augmented norepinephrine turnover caused by bufalin and that these indirect effects of norepinephrine on the cardiovascular system may play a role in the etiology of hypertension. JF - Hypertension (Dallas, Tex. : 1979) AU - Cress, L W AU - Freas, W AU - Haddy, F AU - Muldoon, S M AD - Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 516 EP - 522 VL - 18 IS - 4 SN - 0194-911X, 0194-911X KW - Bufanolides KW - 0 KW - Tetrodotoxin KW - 4368-28-9 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Potassium KW - RWP5GA015D KW - bufalin KW - U549S98QLW KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Animals KW - Saphenous Vein -- metabolism KW - In Vitro Techniques KW - Dogs KW - Potassium -- pharmacology KW - Tetrodotoxin -- pharmacology KW - Electric Stimulation KW - Sodium-Potassium-Exchanging ATPase -- antagonists & inhibitors KW - Norepinephrine -- metabolism KW - Blood Vessels -- metabolism KW - Bufanolides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72135814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Effects+of+bufalin+on+norepinephrine+turnover+in+canine+saphenous+vein.&rft.au=Cress%2C+L+W%3BFreas%2C+W%3BHaddy%2C+F%3BMuldoon%2C+S+M&rft.aulast=Cress&rft.aufirst=L&rft.date=1991-10-01&rft.volume=18&rft.issue=4&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=0194911X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-15 N1 - Date created - 1991-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Progress toward Development in Latin America: From Prebisch to Technological Autonomy AN - 61496048; 199203158 JF - Journal of Developing Areas AU - Looney, Robert E AU - Looney, Robert E AD - US Naval Postgraduate School Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 106 EP - 108 VL - 26 IS - 1 SN - 0022-037X, 0022-037X KW - article KW - 8309: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61496048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+Developing+Areas&rft.atitle=Progress+toward+Development+in+Latin+America%3A+From+Prebisch+to+Technological+Autonomy&rft.au=Looney%2C+Robert+E%3BDietz%2C+James+L&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1991-10-01&rft.volume=26&rft.issue=1&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Journal+of+Developing+Areas&rft.issn=0022037X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - SuppNotes - Edition date: 1990. N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - The Impact of Defence Expenditures on Arab Industrial Development AN - 61641273; 199301511 AB - Data from the US Arms Control Disarmament Agency are used to determine whether military expenditures have stimulated increased levels of Arab industrial production, or whether they have depressed the growth of the region's industrial diversification. Factor & regression analysis reveals that defense expenditures in the Arab world have had little impact on industrial output, while nondefense expenditures have tended to obstruct the region's industrial diversification efforts. It is suggested that the process of Arab industrialization can be better understood by focusing on the relative skill intensities of civilian & defense expenditures. 4 Tables. W. Howard JF - Arms Control AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1991/09// PY - 1991 DA - September 1991 SP - 304 EP - 324 VL - 12 IS - 2 SN - 0144-0381, 0144-0381 KW - Arab industrial production KW - military expenditures KW - government data KW - Expenditures KW - Industrial Production KW - National Security KW - Arab Countries KW - article KW - 8370: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61641273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arms+Control&rft.atitle=The+Impact+of+Defence+Expenditures+on+Arab+Industrial+Development&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1991-09-01&rft.volume=12&rft.issue=2&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Arms+Control&rft.issn=01440381&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Industrial Production; Arab Countries; National Security; Expenditures ER - TY - JOUR T1 - Manic psychosis after coffee and phenylpropanolamine. AN - 72110246; 1912131 JF - Biological psychiatry AU - Lake, C R AD - Department of Psychiatry, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991/08/15/ PY - 1991 DA - 1991 Aug 15 SP - 401 EP - 404 VL - 30 IS - 4 SN - 0006-3223, 0006-3223 KW - Coffee KW - 0 KW - Phenylpropanolamine KW - 33RU150WUN KW - Index Medicus KW - Drug Interactions KW - Humans KW - Adult KW - Female KW - Phenylpropanolamine -- adverse effects KW - Coffee -- adverse effects KW - Bipolar Disorder -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72110246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Manic+psychosis+after+coffee+and+phenylpropanolamine.&rft.au=Lake%2C+C+R&rft.aulast=Lake&rft.aufirst=C&rft.date=1991-08-15&rft.volume=30&rft.issue=4&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cross-linkage of Ly-6A/E induces Ca2+ translocation in the absence of phosphatidylinositol turnover and mediates proliferation of normal murine B lymphocytes. AN - 72027582; 1907991 AB - Ly-6A/E is a phosphatidylinositol (PI)-linked membrane protein whose expression is induced or upregulated on normal murine T and B cells by IFN-gamma. Cross-linkage of Ly-6A/E expressed on normal murine T cells stimulates Ca2+ translocation, and in the presence of a protein kinase C (PKC) activator, lymphokine secretion, and cellular proliferation. Utilizing an anti-Ly-6A/E mAb, we studied the effect of cross-linking Ly-6A/E on IFN-gamma-treated resting B cells, for Ca2+ translocation, PI turnover, and cellular proliferation. Since these events are known to be stimulated by cross-linkage of B cell membrane (m)Ig, we compared the changes mediated through these respective membrane proteins. We show that cross-linkage of B cell Ly-6A/E stimulates a large, rapid, and sustained increase in the concentration of intracellular free calcium ([Ca2+]i) comparable in magnitude, though somewhat delayed, relative to that observed after cross-linking of mIg. Cross-linkage of B cell Ly-6A/E does not, however, stimulate detectable PI turnover, in contrast to PI turnover induced by ligation of mIg. Both the Ly-6A/E- and mIg-mediated increase in [Ca2+]i occur through mobilization of internal Ca2+ stores as well as entry of Ca2+ into the cell from the extracellular compartment. Ly-6A/E-mediated Ca2+ translocation appears to be under the regulation of PKC in that short term pretreatment of B cells with the PKC activator, PMA, inhibits the Ly-6A/E- as well as the mIg-mediated increase in [Ca2+]i, whereas prolonged exposure to PMA, under conditions that lead to depletion of PKC, results in an augmentation in Ca2+ translocation after ligation of either Ly-6A/E or mIg. Co-capping studies indicate that Ly-6A/E and mIg cap independently in the B cell membrane, thus suggesting that the Ly-6A/E-induced effects on Ca2+ translocation are not mediated through simultaneous modulation of mIg. Anti-Ly6A/E, by itself, does not stimulate an increase in [3H]thymidine incorporation by IFN-gamma-treated resting B cells, but induces a striking increase in the presence of PMA. By contrast, anti-Ig by itself stimulates significant increases in [3H]thymidine incorporation that is inhibited by PMA. Thus, Ly-6A/E is a potent mediator of B cell activation that may use a signal transduction system in quiescent B cells that is distinct from that of the Ag receptor. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Snapper, C M AU - Yamada, H AU - Mond, J J AU - June, C H AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1991/08/15/ PY - 1991 DA - 1991 Aug 15 SP - 1171 EP - 1179 VL - 147 IS - 4 SN - 0022-1767, 0022-1767 KW - Antigens, Ly KW - 0 KW - Immunoglobulin D KW - Metals, Rare Earth KW - Phosphatidylinositols KW - Interferon-gamma KW - 82115-62-6 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Immunoglobulin D -- physiology KW - Animals KW - Metals, Rare Earth -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Interferon-gamma -- pharmacology KW - Mice KW - Protein Kinase C -- physiology KW - Mice, Inbred BALB C KW - Mice, Inbred AKR KW - Lymphocyte Activation -- drug effects KW - Calcium -- metabolism KW - Phosphatidylinositols -- metabolism KW - Antigens, Ly -- analysis KW - B-Lymphocytes -- immunology KW - Antigens, Ly -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72027582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Cross-linkage+of+Ly-6A%2FE+induces+Ca2%2B+translocation+in+the+absence+of+phosphatidylinositol+turnover+and+mediates+proliferation+of+normal+murine+B+lymphocytes.&rft.au=Snapper%2C+C+M%3BYamada%2C+H%3BMond%2C+J+J%3BJune%2C+C+H&rft.aulast=Snapper&rft.aufirst=C&rft.date=1991-08-15&rft.volume=147&rft.issue=4&rft.spage=1171&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-16 N1 - Date created - 1991-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Evaluation of the role of Shiga and Shiga-like toxins in mediating direct damage to human vascular endothelial cells. AN - 80700981; 1649877 AB - Infection with Shiga toxin- and Shiga-like toxin-producing strains of Shigella dysenteriae and Escherichia coli, respectively, can progress to the hemolytic-uremic syndrome. It has been hypothesized that circulating Shiga toxin, Shiga-like toxins, and endotoxins may contribute to the disease by directly damaging glomerular endothelial cells. The effects of these toxins on HeLa, Vero, and human vascular endothelial cells (EC) were examined. Confluent EC were sensitive to Shiga toxin but were at least 10(6)-fold less sensitive to the toxins than were Vero cells. Shiga toxin was the predominant cytotoxic factor. Lipopolysaccharides were not cytotoxic and did not augment Shiga toxin-mediated toxicity. Lower doses of Shiga toxin caused cytotoxicity when coincubated with tumor necrosis factor. The relative resistance of EC to Shiga toxin and Shiga-like toxins may be due to reduced toxin binding, as low levels of globotriaosylceramide (Gb3), the toxin-specific receptor, were found in EC membranes. JF - The Journal of infectious diseases AU - Tesh, V L AU - Samuel, J E AU - Perera, L P AU - Sharefkin, J B AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 344 EP - 352 VL - 164 IS - 2 SN - 0022-1899, 0022-1899 KW - Bacterial Toxins KW - 0 KW - Cytotoxins KW - Enterotoxins KW - Glycolipids KW - Lipopolysaccharides KW - Receptors, Cell Surface KW - Receptors, Peptide KW - Recombinant Proteins KW - Shiga Toxin 2 KW - Shiga Toxins KW - Tumor Necrosis Factor-alpha KW - Guanylate Cyclase KW - EC 4.6.1.2 KW - Receptors, Guanylate Cyclase-Coupled KW - enterotoxin receptor KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - HeLa Cells -- drug effects KW - Cytotoxins -- toxicity KW - Vero Cells -- drug effects KW - Humans KW - Receptors, Cell Surface -- analysis KW - Shigella KW - Cell Survival KW - Recombinant Proteins -- toxicity KW - Tumor Necrosis Factor-alpha -- toxicity KW - Cells, Cultured KW - Binding, Competitive KW - Escherichia coli KW - Lipopolysaccharides -- toxicity KW - Glycolipids -- metabolism KW - Bacterial Toxins -- metabolism KW - Enterotoxins -- metabolism KW - Endothelium, Vascular -- cytology KW - Bacterial Toxins -- toxicity KW - Enterotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80700981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Evaluation+of+the+role+of+Shiga+and+Shiga-like+toxins+in+mediating+direct+damage+to+human+vascular+endothelial+cells.&rft.au=Tesh%2C+V+L%3BSamuel%2C+J+E%3BPerera%2C+L+P%3BSharefkin%2C+J+B%3BO%27Brien%2C+A+D&rft.aulast=Tesh&rft.aufirst=V&rft.date=1991-08-01&rft.volume=164&rft.issue=2&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-23 N1 - Date created - 1991-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The pathogenic mechanisms of Shiga toxin and the Shiga-like toxins. AN - 72596505; 1766367 AB - It is now well documented that some enteric bacteria which cause diarrhoeal and/or dysenteric disease produce, at high levels, one or more of a family of protein toxins referred to as Shiga toxin and Shiga-like toxins (SLTs; alternatively called verocytotoxins or VTs). Within the past few years, there have been considerable advancements made in our understanding of the biochemistry and molecular biology of Shiga toxin and SLTs. However, the precise role of the toxins in mediating colonic disease, as well as their contribution to the development of extra-intestinal sequelae (e.g. the haemolytic uraemic syndrome and neurological disorders), remain less clear. In this MicroReview, we will briefly summarize recent progress in Shiga toxin- and SLT-related research and present evidence supporting the concept that these toxins contribute to pathogenesis by directly damaging vascular endothelial cells, thereby disrupting the homeostatic properties of these cells. We will also discuss data which suggest that toxin-mediated damage in the kidney may not be limited to glomerular endothelial cells but may include tubular epithelial cells. Thus, the role of the toxins in renal disease may not be limited to the glomeruli, as was initially hypothesized when the association of infection with toxin-producing strains and the development of acute renal failure was established. JF - Molecular microbiology AU - Tesh, V L AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services, University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 1817 EP - 1822 VL - 5 IS - 8 SN - 0950-382X, 0950-382X KW - Bacterial Toxins KW - 0 KW - Shiga Toxin 1 KW - Shiga Toxin 2 KW - Shiga Toxins KW - Index Medicus KW - Hemolytic-Uremic Syndrome -- microbiology KW - Dysentery, Bacillary -- microbiology KW - Animals KW - Dysentery, Bacillary -- pathology KW - Humans KW - Enterobacteriaceae Infections -- microbiology KW - Enterobacteriaceae Infections -- pathology KW - Escherichia coli KW - Bacterial Toxins -- toxicity KW - Shigella dysenteriae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72596505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=The+pathogenic+mechanisms+of+Shiga+toxin+and+the+Shiga-like+toxins.&rft.au=Tesh%2C+V+L%3BO%27Brien%2C+A+D&rft.aulast=Tesh&rft.aufirst=V&rft.date=1991-08-01&rft.volume=5&rft.issue=8&rft.spage=1817&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-14 N1 - Date created - 1992-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Platelet-activating factor in stroke and brain injury. AN - 72113076; 1897906 AB - Platelet-activating factor, an endogenous phospholipid of proinflammatory, hemostatic, and vasoactive properties, is synthesized by neurons and in injured brain. Platelet-activating factor is released together with eicosanoids such as thromboxane A2, prostacyclin, and leukotrienes. Its effects in neurons are mediated through a specific receptor coupled to phospholipase C and phosphoinositol metabolism. The cerebrovascular effects of platelet-activating factor include disruption of the blood-brain barrier, edema formation, and vasospasm. It has also been described to possess direct toxicity to neuronal cells in culture. Discovery and development of several highly potent and selective antagonists to platelet-activating factor receptors facilitated experimental studies underscoring the role of this factor as an endogenous mediator in cerebral disorders, particularly cerebral ischemia and trauma. Significant biochemical, microvascular, functional, and behavioral recovery has been demonstrated using these antagonists in an array of experimental models of focal and global ischemia in the central nervous system (CNS). Clearly, studies of platelet-activating factor in experimental models of CNS ischemia and reperfusion injury open a new perspective on phospholipid metabolism in stroke and offer an exceptionally promising therapeutic prospect. Data supporting this factor as a mediator of specific pathological sequelae in stroke and neuroinjury are surveyed in this review. We discuss the mechanisms and significance of platelet-activating factor-mediated effects and propose directions for future studies. JF - Annals of neurology AU - Lindsberg, P J AU - Hallenbeck, J M AU - Feuerstein, G AD - Department of Neurology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 117 EP - 129 VL - 30 IS - 2 SN - 0364-5134, 0364-5134 KW - Platelet Activating Factor KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Platelet Activating Factor -- antagonists & inhibitors KW - Brain Injuries -- physiopathology KW - Platelet Activating Factor -- physiology KW - Brain Ischemia -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72113076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+neurology&rft.atitle=Platelet-activating+factor+in+stroke+and+brain+injury.&rft.au=Lindsberg%2C+P+J%3BHallenbeck%2C+J+M%3BFeuerstein%2C+G&rft.aulast=Lindsberg&rft.aufirst=P&rft.date=1991-08-01&rft.volume=30&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Annals+of+neurology&rft.issn=03645134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-24 N1 - Date created - 1991-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Roles of interleukin-1 and tumor necrosis factor in lipopolysaccharide-induced hypoglycemia. AN - 80618189; 1828792 AB - In this study, hypoglycemia induced by injection of lipopolysaccharide (LPS) or the recombinant cytokine interleukin-1 alpha or tumor necrosis factor alpha (administered alone or in combination) was compared. LPS-induced hypoglycemia was reversed significantly by recombinant interleukin-1 receptor antagonist. JF - Infection and immunity AU - Vogel, S N AU - Henricson, B E AU - Neta, R AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 2494 EP - 2498 VL - 59 IS - 7 SN - 0019-9567, 0019-9567 KW - Il1rn protein, mouse KW - 0 KW - Interleukin 1 Receptor Antagonist Protein KW - Interleukin-1 KW - Lipopolysaccharides KW - Proteins KW - Receptors, Immunologic KW - Receptors, Interleukin-1 KW - Recombinant Proteins KW - Sialoglycoproteins KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Proteins -- pharmacology KW - Animals KW - Recombinant Proteins -- pharmacology KW - Mice KW - Receptors, Immunologic -- antagonists & inhibitors KW - Female KW - Interleukin-1 -- physiology KW - Lipopolysaccharides -- pharmacology KW - Tumor Necrosis Factor-alpha -- physiology KW - Hypoglycemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80618189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Roles+of+interleukin-1+and+tumor+necrosis+factor+in+lipopolysaccharide-induced+hypoglycemia.&rft.au=Vogel%2C+S+N%3BHenricson%2C+B+E%3BNeta%2C+R&rft.aulast=Vogel&rft.aufirst=S&rft.date=1991-07-01&rft.volume=59&rft.issue=7&rft.spage=2494&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-24 N1 - Date created - 1991-07-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 1988 Mar 1;167(3):1086-99 [3258350] Infect Immun. 1988 Oct;56(10):2650-7 [3262089] Am J Physiol. 1987 Nov;253(5 Pt 2):R794-8 [3318508] J Immunol. 1987 Apr 1;138(7):2143-8 [3494061] J Exp Med. 1986 Jun 1;163(6):1433-50 [3486936] Infect Immun. 1987 Jul;55(7):1622-5 [3596805] Science. 1986 Oct 24;234(4775):470-4 [3764421] Infect Immun. 1990 Jul;58(7):2397-400 [1694829] Infect Immun. 1990 Aug;58(8):2429-37 [1695201] J Clin Invest. 1990 May;85(5):1694-7 [2139669] Nature. 1990 Jan 25;343(6256):341-6 [2137201] Nature. 1990 Jan 25;343(6256):336-40 [2137200] FASEB J. 1990 Aug;4(11):2860-7 [2199284] J Biol Chem. 1990 Aug 15;265(23):13578-83 [2380175] Am J Physiol. 1977 Feb;232(2):E180-5 [320877] Infect Immun. 1971 Aug;4(2):138-42 [4949483] Biochemistry. 1967 Aug;6(8):2363-72 [4867999] Infect Immun. 1991 Mar;59(3):1188-91 [1825485] Infect Immun. 1989 Jul;57(7):2072-8 [2731984] J Immunol. 1986 Aug 1;137(3):858-62 [3487590] Circ Shock. 1987;22(2):155-71 [3297379] Prog Clin Biol Res. 1988;264:355-60 [3289031] Proc Natl Acad Sci U S A. 1989 Oct;86(20):8034-8 [2530580] Proc Natl Acad Sci U S A. 1989 Aug;86(15):5943-7 [2668949] Prog Clin Biol Res. 1989;286:203-18 [2648411] Circ Shock. 1988 Feb;24(2):111-21 [3370760] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Formation of single and double strand breaks in DNA ultraviolet irradiated at high intensity. AN - 72463915; 1946694 AB - The induction of single-strand breaks (SSB) by two quantum processes in DNA is well established. We now report that biphotonic processes result in double-strand breaks (DSB) as well. pUC19 and bacteriophage M13 RF DNA were irradiated using an excimer laser (248 nm) at intensities of 10(7), 10(9), 10(10) and 10(11) W/m2 and doses up to 30 kJ/m2. The proportion of DNA as supercoil, open circular, linear and short fragments was determined by gel electrophoresis. Linear molecules were noted at fluences where supercoiled DNA was still present. The random occurrence of independent SSB in proximity to each other on opposite strands (producing linear DNA) implies introduction of numerous SSB per molecule in the sample. If so, supercoiled DNA that has sustained no SSB should not be observed. A model accounting for the amounts of supercoiled, open circular, linear and shorter fragments of DNA due to SSB, DSB and Scissions (opposition of two independently occurring SSB producing an apparent DSB) was developed, our experimental data and those of others were fit to the model, and quantum yields determined for SSB and DSB formation at each intensity. Results showed that high intensity laser radiation caused an increase in the quantum yields for both SSB and DSB formation. The mechanism of DSB formation is unknown, and may be due to simultaneous cleavage of both strands in one biphotonic event or the biased introduction of an SSB opposite a preexisting SSB, requiring two biphotonic events. JF - Photochemistry and photobiology AU - Masnyk, T W AU - Minton, K W AD - Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889-4799. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 99 EP - 107 VL - 54 IS - 1 SN - 0031-8655, 0031-8655 KW - DNA, Single-Stranded KW - 0 KW - DNA, Viral KW - Deoxyribonuclease I KW - EC 3.1.21.1 KW - Index Medicus KW - Kinetics KW - Escherichia coli -- genetics KW - Coliphages -- genetics KW - Dose-Response Relationship, Radiation KW - Models, Theoretical KW - Mathematics KW - Ultraviolet Rays KW - DNA Damage KW - Plasmids -- radiation effects KW - DNA, Viral -- radiation effects KW - DNA, Single-Stranded -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72463915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Formation+of+single+and+double+strand+breaks+in+DNA+ultraviolet+irradiated+at+high+intensity.&rft.au=Masnyk%2C+T+W%3BMinton%2C+K+W&rft.aulast=Masnyk&rft.aufirst=T&rft.date=1991-07-01&rft.volume=54&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-13 N1 - Date created - 1991-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Analysis of structure and function of the B subunit of cholera toxin by the use of site-directed mutagenesis. AN - 72461130; 1943708 AB - Oligonucleotide-directed mutagenesis of ctxB was used to produce mutants of cholera toxin B subunit (CT-B) altered at residues Cys-9, Gly-33, Lys-34, Arg-35, Cys-86 and Trp-88. Mutants were identified phenotypically by radial passive immune haemolysis assays and genotypically by colony hybridization with specific oligonucleotide probes. Mutant CT-B polypeptides were characterized for immunoreactivity, binding to ganglioside GM1, ability to associate with the A subunit, ability to form holotoxin, and biological activity. Amino acid substitutions that caused decreased binding of mutant CT-B to ganglioside GM1 and abolished toxicity included negatively charged or large hydrophobic residues for Gly-33 and negatively or positively charged residues for Trp-88. Substitution of lysine or arginine for Gly-33 did not affect immunoreactivity or GM1-binding activity of CT-B but abolished or reduced toxicity of the mutant holotoxins, respectively. Substitutions of Glu or Asp for Arg-35 interfered with formation of holotoxin, but none of the observed substitutions for Lys-34 or Arg-35 affected binding of CT-B to GM1. The Cys-9, Cys-86 and Trp-88 residues were important for establishing or maintaining the native conformation of CT-B or protecting the CT-B polypeptide from rapid degradation in vivo. JF - Molecular microbiology AU - Jobling, M G AU - Holmes, R K AD - Department of Microbiology, F. Edward Herbert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 1755 EP - 1767 VL - 5 IS - 7 SN - 0950-382X, 0950-382X KW - Enterotoxins KW - 0 KW - Gangliosides KW - stN protein, Vibrio cholerae KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Biosynthesis KW - Base Sequence KW - Hemolysis -- immunology KW - DNA Mutational Analysis KW - Molecular Sequence Data KW - Gene Expression KW - Transcription, Genetic KW - Binding Sites -- genetics KW - Plasmids KW - Structure-Activity Relationship KW - Immunoassay KW - Cloning, Molecular KW - Enterotoxins -- chemistry KW - Enterotoxins -- genetics KW - Gangliosides -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72461130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Analysis+of+structure+and+function+of+the+B+subunit+of+cholera+toxin+by+the+use+of+site-directed+mutagenesis.&rft.au=Jobling%2C+M+G%3BHolmes%2C+R+K&rft.aulast=Jobling&rft.aufirst=M&rft.date=1991-07-01&rft.volume=5&rft.issue=7&rft.spage=1755&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-13 N1 - Date created - 1991-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Back pain after epidural anesthesia with chloroprocaine in volunteers: preliminary report. AN - 72109435; 1832945 AB - The incidence, character and treatment of backache associated with epidural anesthesia (EA) using 3% chloroprocaine (2-CP, Nesacaine-MPF) were observed in ten volunteers undergoing a study of the effects of EA upon plasma catecholamines. Three levels of epidural analgesia were sequentially sought, T10, T4 and C8, in ascending order. Each block was allowed to fully dissipate prior to the next injection. For the first, second and third injections, 15-20 ml, 25-35 ml and 52-60 ml, respectively, of 3% 2-CP were injected via an epidural catheter. Mean total volume of 2-CP injected was 103 ml (range, 92-115 ml) over seven hours. Back pain was first reported after as little as 15 ml (mean +/- SEM, 24.0 +/- 3.9 ml; range, 15-45 ml). The pain was described as a dull ache deep in the lumbar back, ranging in severity from mild to severe. No profound spasm of the erector spinae muscles was observed. Mean verbal analog scale pain scores after regression of the first, second and third blocks were 2.2, 4.3 and 6.5, respectively. Epidural fentanyl (100-200 micrograms) was effective in providing rapid relief of the pain. Large doses or possibly repeated injections of epidural Nesacaine-MPF are associated with an increased incidence and severity of postanesthesia lumbar back pain. JF - Regional anesthesia AU - Stevens, R A AU - Chester, W L AU - Artuso, J D AU - Bray, J G AU - Nellestein, J A AD - Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. PY - 1991 SP - 199 EP - 203 VL - 16 IS - 4 SN - 0146-521X, 0146-521X KW - Anesthetics, Local KW - 0 KW - Procaine KW - 4Z8Y51M438 KW - chloroprocaine KW - 5YVB0POT2H KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Humans KW - Adult KW - Fentanyl -- therapeutic use KW - Male KW - Injections, Epidural KW - Fentanyl -- administration & dosage KW - Female KW - Procaine -- analogs & derivatives KW - Back Pain -- etiology KW - Anesthetics, Local -- adverse effects KW - Anesthesia, Epidural -- adverse effects KW - Back Pain -- drug therapy KW - Procaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72109435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regional+anesthesia&rft.atitle=Back+pain+after+epidural+anesthesia+with+chloroprocaine+in+volunteers%3A+preliminary+report.&rft.au=Stevens%2C+R+A%3BChester%2C+W+L%3BArtuso%2C+J+D%3BBray%2C+J+G%3BNellestein%2C+J+A&rft.aulast=Stevens&rft.aufirst=R&rft.date=1991-07-01&rft.volume=16&rft.issue=4&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Regional+anesthesia&rft.issn=0146521X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-21 N1 - Date created - 1991-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The inheritance of conotruncal malformations: a review and report of two siblings with tetralogy of Fallot with pulmonary atresia. AN - 72070185; 1884513 AB - Congenital heart defects (CHD) are a group of structural abnormalities that in humans have a combined incidence of approximately 1%. It is estimated that 4-5% of CHD are associated with chromosome abnormalities, 1-2% are associated with single gene syndromes, 1-2% are due to known teratogens, with the rest presumably determined multifactorially. We report on a brother and sister with tetralogy of Fallot with pulmonary atresia, and review the inheritance of familial conotruncal anomalies. We feel the small number of family clusters and the rare instances of consanguinity in non-syndromal conotruncal defects are consistent with multifactorial determination. While it is prudent in counseling families with 2 or more individuals with conotruncal CHD to raise the possibility of single gene inheritance, we believe that current empiric recurrence risk estimates most accurately reflect their risks. JF - Clinical genetics AU - Wulfsberg, E A AU - Zintz, E J AU - Moore, J W AD - Medical Genetics/Dysmorphology, National Naval Medical Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 12 EP - 16 VL - 40 IS - 1 SN - 0009-9163, 0009-9163 KW - Index Medicus KW - Pedigree KW - Risk Factors KW - Humans KW - Infant, Newborn KW - Incidence KW - Genetic Counseling KW - Cluster Analysis KW - Recurrence KW - Male KW - Female KW - Abnormalities, Multiple -- genetics KW - Tetralogy of Fallot -- epidemiology KW - Pulmonary Artery -- abnormalities KW - Abnormalities, Multiple -- epidemiology KW - Tetralogy of Fallot -- prevention & control KW - Tetralogy of Fallot -- genetics KW - Abnormalities, Multiple -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72070185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+genetics&rft.atitle=The+inheritance+of+conotruncal+malformations%3A+a+review+and+report+of+two+siblings+with+tetralogy+of+Fallot+with+pulmonary+atresia.&rft.au=Wulfsberg%2C+E+A%3BZintz%2C+E+J%3BMoore%2C+J+W&rft.aulast=Wulfsberg&rft.aufirst=E&rft.date=1991-07-01&rft.volume=40&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Clinical+genetics&rft.issn=00099163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-10 N1 - Date created - 1991-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enlistment Motivations of Army Reservists: Money, Self-Improvement, or Patriotism? AN - 61302564; 92Y5605 AB - Self-reported motives for enlistment in the US Army Reserve are examined as a function of age, educational attainment & proficiency, & plans to transfer to the active Army, drawing on survey data obtained from 1,364 male recruits in 1987. Several differently motivated subgroups of reserve recruits are suggested: those of traditional college age & more intellectually gifted tend to join seeking money, primarily for college; this trend is most pronounced for the youngest high school graduate recruits. Older recruits or those less intellectualy predisposed joined for self-improvement or skills training. The youngest recruits joined largely to transfer to the active Army. 3 Tables. Adapted from the source document. JF - Armed Forces and Society AU - Gorman, Linda AU - Thomas, George W AD - Dept Administrative Sciences Naval Postgraduate School, Monterey CA 93943 Y1 - 1991/07// PY - 1991 DA - July 1991 SP - 589 EP - 599 VL - 17 IS - 4 SN - 0095-327X, 0095-327X KW - enlistment motivations, US Army Reserve KW - age/education KW - survey KW - male recruits KW - Motivation KW - Males KW - Psychosocial Factors KW - Recruitment KW - United States of America KW - Educational Attainment KW - Armed Forces KW - Age Differences KW - article KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61302564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Armed+Forces+and+Society&rft.atitle=Enlistment+Motivations+of+Army+Reservists%3A+Money%2C+Self-Improvement%2C+or+Patriotism%3F&rft.au=Gorman%2C+Linda%3BThomas%2C+George+W&rft.aulast=Gorman&rft.aufirst=Linda&rft.date=1991-07-01&rft.volume=17&rft.issue=4&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Armed+Forces+and+Society&rft.issn=0095327X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AFSOD2 N1 - SubjectsTermNotLitGenreText - Recruitment; United States of America; Armed Forces; Age Differences; Educational Attainment; Males; Motivation; Psychosocial Factors ER - TY - JOUR T1 - Potentiation of the toxicity of model hepatotoxicants by acetaminophen. AN - 80678477; 2068730 AB - A 24-hr oral pretreatment of rats with 1.6 g/kg acetaminophen potentiated hepatotoxicity of allyl alcohol, bromobenzene, carbon tetrachloride, 1,1-dichloroethylene, and thioacetamide, as assessed by elevation of serum alanine aminotransferase activity and histopathological examination. Doses, of these hepatotoxicants, which did not cause hepatocellular necrosis, became necrogenic after acetaminophen pretreatment with all toxicants except thioacetamide. Acetaminophen pretreatment did not decrease the threshold dose of toxicity for thioacetamide but did accentuate hepatotoxic doses. Acetaminophen pretreatment potentiated lethality of allyl alcohol and 1,1-dichloroethylene. Upon necropsy, these rats had congested livers and appeared to suffer from hypovolemic shock. We conclude that while acetaminophen was not necrogenic at the doses used in this study, it produced alterations that make hepatocytes much more susceptible to hepatotoxic insult. JF - Toxicology and applied pharmacology AU - Wright, P B AU - Moore, L AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991/06/15/ PY - 1991 DA - 1991 Jun 15 SP - 327 EP - 335 VL - 109 IS - 2 SN - 0041-008X, 0041-008X KW - Bromobenzenes KW - 0 KW - Dichloroethylenes KW - Propanols KW - Thioacetamide KW - 075T165X8M KW - vinylidene chloride KW - 21SK105J9D KW - Acetaminophen KW - 362O9ITL9D KW - allyl alcohol KW - 3W678R12M0 KW - 1-Propanol KW - 96F264O9SV KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - bromobenzene KW - CO4D5J547L KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Animals KW - Bromobenzenes -- toxicity KW - Alanine Transaminase -- metabolism KW - Carbon Tetrachloride -- toxicity KW - Models, Biological KW - Dichloroethylenes -- toxicity KW - Rats KW - Rats, Inbred Strains KW - Thioacetamide -- toxicity KW - 1-Propanol -- toxicity KW - Drug Synergism KW - Time Factors KW - Male KW - Liver -- drug effects KW - Acetaminophen -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80678477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Potentiation+of+the+toxicity+of+model+hepatotoxicants+by+acetaminophen.&rft.au=Wright%2C+P+B%3BMoore%2C+L&rft.aulast=Wright&rft.aufirst=P&rft.date=1991-06-15&rft.volume=109&rft.issue=2&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-09 N1 - Date created - 1991-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Iron-dependent regulation of diphtheria toxin and siderophore expression by the cloned Corynebacterium diphtheriae repressor gene dtxR in C. diphtheriae C7 strains. AN - 80578913; 1828057 AB - A regulatory gene (dtxR) responsible for iron-dependent repression of the toxin (tox) and siderophore genes in Corynebacterium diphtheriae was cloned and characterized. A DNA fragment carrying dtxR repressed expression of a tox-lacZ gene fusion in Escherichia coli DH5 alpha in a high-iron environment but not under low-iron conditions. A protein with mobility corresponding to approximately 28 to 29 kDa was identified as the product of the dtxR gene by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A shuttle vector designated pCM2.6 was constructed which carries the origin of replication from C. diphtheriae plasmid pNG2 and confers resistance to chloramphenicol in E. coli and C. diphtheriae. DNA fragments carrying dtxR were cloned into pCM2.6, and the hybrid shuttle plasmids were transformed by electroporation into wild-type C. diphtheriae C7(beta) and the regulatory mutant C7(beta)hm723, which produces toxin and siderophore constitutively under high-iron conditions. Expression of the cloned dtxR determinant did not affect the phenotype of C. diphtheriae C7(beta). In C. diphtheriae C7(beta)hm723, expression of cloned dtxR restored full repression of siderophore production and partial repression of diphtheria toxin production during growth in a high-iron environment. JF - Infection and immunity AU - Schmitt, M P AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991/06// PY - 1991 DA - June 1991 SP - 1899 EP - 1904 VL - 59 IS - 6 SN - 0019-9567, 0019-9567 KW - dtxR KW - tox KW - DNA, Bacterial KW - 0 KW - Diphtheria Toxin KW - Iron Chelating Agents KW - Repressor Proteins KW - Siderophores KW - Chloramphenicol KW - 66974FR9Q1 KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Chloramphenicol -- pharmacology KW - Plasmids -- genetics KW - Electrophoresis, Polyacrylamide Gel KW - Transfection -- genetics KW - Escherichia coli -- drug effects KW - Drug Resistance, Microbial KW - Escherichia coli -- genetics KW - DNA, Bacterial -- analysis KW - Cloning, Molecular KW - Iron -- pharmacology KW - Diphtheria Toxin -- metabolism KW - Iron Chelating Agents -- metabolism KW - Gene Expression Regulation, Bacterial -- drug effects KW - Corynebacterium diphtheriae -- genetics KW - Corynebacterium diphtheriae -- drug effects KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80578913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Iron-dependent+regulation+of+diphtheria+toxin+and+siderophore+expression+by+the+cloned+Corynebacterium+diphtheriae+repressor+gene+dtxR+in+C.+diphtheriae+C7+strains.&rft.au=Schmitt%2C+M+P%3BHolmes%2C+R+K&rft.aulast=Schmitt&rft.aufirst=M&rft.date=1991-06-01&rft.volume=59&rft.issue=6&rft.spage=1899&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-28 N1 - Date created - 1991-06-28 N1 - Date revised - 2017-01-13 N1 - Gene symbol - dtxR; tox N1 - SuppNotes - Cited By: Microb Pathog. 1990 Oct;9(4):267-73 [2151460] J Virol. 1976 Apr;18(1):235-44 [815566] Microbiol Rev. 1987 Dec;51(4):509-18 [2963952] Proc Natl Acad Sci U S A. 1985 Feb;82(4):1074-8 [3156376] Mol Gen Genet. 1985;200(1):110-3 [2993806] Proc Natl Acad Sci U S A. 1987 Jul;84(14):4964-8 [3110777] Infect Immun. 1988 Sep;56(9):2430-6 [3044999] Nature. 1988 Nov 24;336(6197):392-5 [2904127] Proc Natl Acad Sci U S A. 1990 Aug;87(15):5968-72 [2116013] FEMS Microbiol Lett. 1990 Jan 1;54(1-3):119-23 [2108894] Infect Immun. 1984 Jul;45(1):143-9 [6429042] J Bacteriol. 1980 Aug;143(2):971-80 [6162838] Gene. 1983 Dec;26(1):101-6 [6323249] Anal Biochem. 1981 Jun;114(1):193-7 [6269464] Antimicrob Agents Chemother. 1980 Nov;18(5):814-21 [6255866] J Bacteriol. 1983 Apr;154(1):245-52 [6403502] J Bacteriol. 1983 Sep;155(3):1439-42 [6411692] J Mol Biol. 1983 Jun 5;166(4):557-80 [6345791] Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 [6546423] J Virol. 1981 Mar;37(3):936-45 [6785449] Annu Rev Biochem. 1977;46:69-94 [20040] J Bacteriol. 1978 Jun;134(3):1141-56 [149110] Infect Immun. 1977 Oct;18(1):203-9 [409685] Proc Natl Acad Sci U S A. 1974 Jan;71(1):11-5 [4204202] J Virol. 1969 Jun;3(6):586-98 [4978942] Anal Biochem. 1987 Jan;160(1):47-56 [2952030] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Conceptual and methodological considerations for tobacco addiction research. AN - 80709248; 1859932 AB - The 1988 Surgeon General's Report on nicotine addiction has research and treatment implications. It focuses clinical treatments on tobacco use as an addiction and highlights the importance of examining actions of nicotine relevant to dependence. It also indicates the value of comparing the pharmacologic and behavioral processes underlying use of nicotine with other addictive drugs. This essay points out gaps that remain in our understanding of nicotine addiction. For example, the exact mechanisms underlying nicotine addiction are unknown. Also, the reasons for individual differences in initiation, withdrawal, relapse and reinforcing effects of tobacco use are not understood. Research designed to address these issues should be problem-driven and multidisciplinary. Parallel human and animal studies that include unconditioned as well as conditioned behaviors are particularly valuable. JF - British journal of addiction AU - Grunberg, N E AU - Acri, J B AD - Uniformed Services University of the Health Sciences, Department of Medical Psychology, Bethesda, Maryland. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 637 EP - 641 VL - 86 IS - 5 SN - 0952-0481, 0952-0481 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Brain -- physiopathology KW - Animals KW - Psychophysiology KW - Arousal -- drug effects KW - Risk Factors KW - Humans KW - Brain -- drug effects KW - Arousal -- physiology KW - Substance-Related Disorders -- physiopathology KW - Smoking -- physiopathology KW - Nicotine -- adverse effects KW - Smoking -- psychology KW - Smoking -- prevention & control KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80709248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+addiction&rft.atitle=Conceptual+and+methodological+considerations+for+tobacco+addiction+research.&rft.au=Grunberg%2C+N+E%3BAcri%2C+J+B&rft.aulast=Grunberg&rft.aufirst=N&rft.date=1991-05-01&rft.volume=86&rft.issue=5&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=British+journal+of+addiction&rft.issn=09520481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-05 N1 - Date created - 1991-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased radiation resistance in transformed and nontransformed cells with elevated ras proto-oncogene expression. AN - 80538349; 2023995 AB - The cellular Ha-ras oncogene, activated by missense mutations, has been implicated in intrinsic resistance to ionizing radiation. This study shows that the overexpression of the unmutated gene (proto-oncogene) may also be involved in how the cells respond to radiation. The experimental system consisted of mouse NIH 3T3-derived cell lines which carry multiple copies of a transcriptionally activated human c-Ha-ras proto-oncogene. Both tumorigenic (RS485) and revertant nontumorigenic subclones (PR4 and 4C3) which have high levels of ras expression exhibited a marked increase in radioresistance as measured by D0 compared to control NIH 3T3 cells. Other nontransformed cells with elevated levels of ras (phenotypically revertant line 4C8-A10) also had a significantly increased resistance to radiation, further indicating an association between ras and radioresistance. The increased radioresistance of the RS485 and phenotypic revertants could not be explained by a differential expression of the myc or metallothionein I genes or by variations in cell cycle. The correlation between increased ras proto-oncogene expression and radioresistance suggests that the ras encoded p21, a plasma membrane protein, may participate in the cellular responses to ionizing radiation. JF - Radiation research AU - Samid, D AU - Miller, A C AU - Rimoldi, D AU - Gafner, J AU - Clark, E P AD - Pathology Department, Uniformed Services University of The Health Sciences, Bethesda, Maryland. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 244 EP - 250 VL - 126 IS - 2 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Animals KW - Mice KW - Dose-Response Relationship, Radiation KW - Cell Survival -- radiation effects KW - Genes, ras KW - Proto-Oncogenes KW - Cell Transformation, Neoplastic -- genetics KW - Radiation Tolerance -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80538349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Increased+radiation+resistance+in+transformed+and+nontransformed+cells+with+elevated+ras+proto-oncogene+expression.&rft.au=Samid%2C+D%3BMiller%2C+A+C%3BRimoldi%2C+D%3BGafner%2C+J%3BClark%2C+E+P&rft.aulast=Samid&rft.aufirst=D&rft.date=1991-05-01&rft.volume=126&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-06 N1 - Date created - 1991-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A goldfish model for evaluation of the neurotoxicity of omega-conotoxin GVI A and screening of monoclonal antibodies. AN - 80527425; 1850561 AB - The neurotoxicity of omega-conotoxin (omega-CgTx), a potent neuronal voltage-sensitive calcium channel blocker, was measured using a new bioassay. omega-CgTx was administered intraperitoneally (ip) to goldfish weighing approximately 1.6 g, and dose-related changes were observed over a 2-hr period. omega-CgTx induced time- and dose-dependent abnormal swimming behavior (ASB) and mortality. The antitoxin activity of the antibodies was investigated in vivo by either (1) preincubation of the antibody with omega-CgTx at 4 degrees C overnight, or (2) pretreatment with antibody, 30 min before omega-CgTx injection in a 10:1 antibody/omega-CgTx molar ratio. The LD50 dose of omega-CgTx in goldfish was 5 nmol/kg ip, and preincubation of monoclonal antibody (50 nmol/kg ip) with omega-CgTx (5 nmol/kg ip) significantly (p less than 0.05) reduced mortality, ASB, and toxicity time. The antitoxin activity of the monoclonal antibodies evidenced in the goldfish bioassay was further tested in the conscious rat. In the rat, the increases in mean arterial pressure and heart rate induced by omega-CgTx (0.03 nmol/rat icv) were significantly (p less than 0.02 and p less than 0.01, respectively) attenuated by preincubation of the toxin with the antibody (0.3 nmol/rat). We conclude that the goldfish bioassay provides a simple, accurate, and inexpensive in vivo model for the study of the toxicity of omega-CgTx. JF - Toxicology and applied pharmacology AU - Adeyemo, O M AU - Shapira, S AU - Tombaccini, D AU - Pollard, H B AU - Feuerstein, G AU - Sirén, A L AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 489 EP - 496 VL - 108 IS - 3 SN - 0041-008X, 0041-008X KW - Antibodies, Monoclonal KW - 0 KW - Calcium Channels KW - Peptides, Cyclic KW - omega-Conotoxin GVIA KW - 92078-76-7 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Hemodynamics -- drug effects KW - Animals KW - Calcium Channels -- drug effects KW - Goldfish KW - Male KW - Peptides, Cyclic -- antagonists & inhibitors KW - Neurons -- drug effects KW - Peptides, Cyclic -- toxicity KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80527425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=A+goldfish+model+for+evaluation+of+the+neurotoxicity+of+omega-conotoxin+GVI+A+and+screening+of+monoclonal+antibodies.&rft.au=Adeyemo%2C+O+M%3BShapira%2C+S%3BTombaccini%2C+D%3BPollard%2C+H+B%3BFeuerstein%2C+G%3BSir%C3%A9n%2C+A+L&rft.aulast=Adeyemo&rft.aufirst=O&rft.date=1991-05-01&rft.volume=108&rft.issue=3&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-30 N1 - Date created - 1991-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enhancement of the cytotoxicity of mistletoe lectin-1 (ML-1) by high pH or perturbation in Golgi functions. AN - 72113835; 1910176 AB - We have studied the cytotoxicity of Mistletoe lectin-1 (ML-1), a cytotoxic protein produced by Viscum album, in CHO and V79 cells and in mutant cell lines altered in Golgi functions or in endosomal acidification. In wild-type CHO cells, cytotoxicity of ML-1 was greatly enhanced by ammonium chloride or nigericin. A CHO mutant defective in endosomal acidification (DMPR-2), which is resistant to diphtheria toxin, modeccin and Pseudomonas aeruginosa exotoxin A and hypersensitive to ricin, showed increased sensitivity to ML-1. MonR-31 and MF-1 are monensin- and compactin-resistant mutants derived from CHO and V79 cell lines, respectively, and are presumably altered in Golgi functions. The cytotoxicity of ML-1 was found to be increased in both MonR-31 and MF-1 cells as compared with their parental cells. These results indicate that the effects of chemicals or mutations altering endosomal acidification and Golgi functions on the cytotoxicity of ML-1 are similar to those on ricin cytotoxicity. Our results suggest that the cytotoxicity of ML-1 is enhanced by an increase in endosomal pH, as well as by chemicals or mutations altering the structure/functions of the Golgi regions. Like ricin, the intoxication process of ML-1 may involve the Golgi regions. JF - Die Pharmazie AU - Yoshida, T AU - Zhang, M AU - Chen, C AU - Franz, H AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 349 EP - 351 VL - 46 IS - 5 SN - 0031-7144, 0031-7144 KW - Plant Preparations KW - 0 KW - Plant Proteins KW - Ribosome Inactivating Proteins, Type 2 KW - Toxins, Biological KW - ribosome inactivating protein, Viscum KW - Ammonium Chloride KW - 01Q9PC255D KW - Ricin KW - 9009-86-3 KW - Nigericin KW - RRU6GY95IS KW - Index Medicus KW - Animals KW - Cricetulus KW - Vero Cells -- drug effects KW - Hydrogen-Ion Concentration KW - Ammonium Chloride -- pharmacology KW - Nigericin -- pharmacology KW - Ricin -- toxicity KW - Ovary -- cytology KW - Pseudomonas aeruginosa -- drug effects KW - Mutation KW - Female KW - Cricetinae KW - Cell Survival -- drug effects KW - Golgi Apparatus -- drug effects KW - Toxins, Biological -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72113835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Die+Pharmazie&rft.atitle=Enhancement+of+the+cytotoxicity+of+mistletoe+lectin-1+%28ML-1%29+by+high+pH+or+perturbation+in+Golgi+functions.&rft.au=Yoshida%2C+T%3BZhang%2C+M%3BChen%2C+C%3BFranz%2C+H%3BWu%2C+H+C&rft.aulast=Yoshida&rft.aufirst=T&rft.date=1991-05-01&rft.volume=46&rft.issue=5&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Die+Pharmazie&rft.issn=00317144&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-18 N1 - Date created - 1991-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Ifosfamide vs cyclophosphamide in cancer therapy. AN - 72075663; 1653004 AB - Ifosfamide is a newly available analog of cyclophosphamide in the oxazaphosphorine drug class. Cyclophosphamide has been marketed for 32 years, and it remains a highly effective agent for a wide cross-section of malignancies. Ifosfamide has a similar spectrum of antitumor activity but has different pharmacokinetics that could provide advantages in efficacy. Although ifosfamide has been substituted for cyclophosphamide in many therapeutic regimens, it has not been proven superior to cyclophosphamide in any cancer. Its current use in non-investigational therapy is for metastatic testicular carcinoma and sarcomas. Ifosfamide has a disadvantageous toxicity spectrum compared to cyclophosphamide and a greater financial cost and cost of patient inconvenience for administration. For most malignancies responsive to an oxazaphosphorine, the analog of choice will remain cyclophosphamide. JF - Oncology (Williston Park, N.Y.) AU - Weiss, R B AD - Uniformed Services University of the Health Sciences, Bethesda, MD. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 67 EP - 76; discussion 76-82, 84-6 VL - 5 IS - 5 SN - 0890-9091, 0890-9091 KW - Cyclophosphamide KW - 8N3DW7272P KW - Ifosfamide KW - UM20QQM95Y KW - Index Medicus KW - Testicular Neoplasms -- drug therapy KW - Humans KW - Lung Neoplasms -- drug therapy KW - Soft Tissue Neoplasms -- drug therapy KW - Sarcoma -- drug therapy KW - Carcinoma, Small Cell -- drug therapy KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Male KW - Female KW - Genital Neoplasms, Female -- drug therapy KW - Cyclophosphamide -- administration & dosage KW - Neoplasms -- drug therapy KW - Cyclophosphamide -- therapeutic use KW - Ifosfamide -- adverse effects KW - Ifosfamide -- therapeutic use KW - Ifosfamide -- administration & dosage KW - Cyclophosphamide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72075663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+%28Williston+Park%2C+N.Y.%29&rft.atitle=Ifosfamide+vs+cyclophosphamide+in+cancer+therapy.&rft.au=Weiss%2C+R+B&rft.aulast=Weiss&rft.aufirst=R&rft.date=1991-05-01&rft.volume=5&rft.issue=5&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Williston+Park%2C+N.Y.%29&rft.issn=08909091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-07 N1 - Date created - 1991-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Policy Entrepreneurs: Their Activity Structure and Function in the Policy Process AN - 61628135; 199202002 AB - Public entrepreneurship is the process of introducing innovation -- the generation, translation, & implementation of new ideas -- into the public sector. Here, focusing on the educational policy arena, examined are the activities & behavioral patterns of "policy entrepreneurs," ie, public entrepreneurs who, from outside the formal positions of government, introduce, translate, & help implement new ideas into public practice. Analysis is based on interviews conducted with policy entrepreneurs, governor & staff, & legislators, among others (total N = 134). These data were supplemented by archival research, observations, & background surveys. 2 Figures, 73 References. Adapted from the source document. JF - Journal of Public Administration Research and Theory AU - Roberts, Nancy C AU - King, Paula J AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 147 EP - 175 VL - 1 IS - 2 SN - 1053-1858, 1053-1858 KW - policy entrepreneurs (innovators), education sector, activities/behavior patterns KW - interview/archival/observational/survey data KW - Entrepreneurship KW - Policy Making KW - Educational Policy KW - article KW - 7230: social planning/policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61628135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Administration+Research+and+Theory&rft.atitle=Policy+Entrepreneurs%3A+Their+Activity+Structure+and+Function+in+the+Policy+Process&rft.au=Roberts%2C+Nancy+C%3BKing%2C+Paula+J&rft.aulast=Roberts&rft.aufirst=Nancy&rft.date=1991-04-01&rft.volume=1&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Administration+Research+and+Theory&rft.issn=10531858&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Educational Policy; Policy Making; Entrepreneurship ER - TY - JOUR T1 - Use of a physical box model to examine the role of rate-limited sorption on aquifer remediation AN - 50486327; 1992-010007 JF - Eos, Transactions, American Geophysical Union AU - Burris, D R AU - Goltz, M N AU - Anonymous Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 123 PB - American Geophysical Union, Washington, DC VL - 72 IS - 17 SN - 0096-3941, 0096-3941 KW - organic materials KW - sorption KW - organic compounds KW - experimental studies KW - pollution KW - mass transfer KW - physical models KW - ground water KW - aquifers KW - 21:Hydrogeology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50486327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Use+of+a+physical+box+model+to+examine+the+role+of+rate-limited+sorption+on+aquifer+remediation&rft.au=Burris%2C+D+R%3BGoltz%2C+M+N%3BAnonymous&rft.aulast=Burris&rft.aufirst=D&rft.date=1991-04-01&rft.volume=72&rft.issue=17&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union--Mineralogical Society of America 1991 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1992-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - aquifers; experimental studies; ground water; mass transfer; organic compounds; organic materials; physical models; pollution; sorption ER - TY - JOUR T1 - Two copies of Shiga-like toxin II-related genes common in enterohemorrhagic Escherichia coli strains are responsible for the antigenic heterogeneity of the O157:H- strain E32511. AN - 80456051; 1997410 AB - Thirty-two clinical isolates of Shiga-like toxin (SLT)-producing Escherichia coli associated with single cases or outbreaks of bloody diarrhea, hemorrhagic colitis, the hemolytic uremic syndrome, or edema disease of swine were examined for multiple copies of genes belonging to the slt-I or slt-II toxin families. Five of 19 strains that were known to produce SLT-II or to hybridize to slt-II-specific probes by colony blot were found by Southern hybridization to contain two copies of toxin genes related to slt-II. The genes for two toxins closely related to slt-II were cloned from one of the isolates, Escherichia coli O157:H- strain E32511. One copy of the operon was found to be essentially identical to slt-II; it differed from slt-II by only one nucleotide base. This single nucleotide difference did not affect the predicted amino acid sequence. The predicted amino acid sequence of the A subunit of the second operon was identical to that of SLT-II, but the predicted amino acid sequence of the B subunit was identical to that of the B2F1 toxin VT2ha. We designated this second operon slt-IIc. Neutralization assays using several monoclonal antibodies and polyclonal antiserum prepared against SLT-II showed that SLT-IIc was antigenically related to but distinct from SLT-II. JF - Infection and immunity AU - Schmitt, C K AU - McKee, M L AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 1065 EP - 1073 VL - 59 IS - 3 SN - 0019-9567, 0019-9567 KW - slt-I KW - slt-II KW - slt-IIc KW - slt-IIv KW - vtx2ha KW - vtx2hb KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - DNA, Bacterial KW - Shiga Toxin 2 KW - Index Medicus KW - Animals KW - HeLa Cells KW - Sequence Homology, Nucleic Acid KW - Humans KW - Multigene Family KW - Amino Acid Sequence KW - Nucleic Acid Hybridization KW - Cloning, Molecular KW - Base Sequence KW - Blotting, Southern KW - Molecular Sequence Data KW - Vero Cells KW - Species Specificity KW - Bacterial Toxins -- genetics KW - Genes, Bacterial KW - Escherichia coli -- immunology KW - Escherichia coli -- pathogenicity KW - Escherichia coli -- genetics KW - Bacterial Toxins -- toxicity KW - Antigens, Bacterial -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80456051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Two+copies+of+Shiga-like+toxin+II-related+genes+common+in+enterohemorrhagic+Escherichia+coli+strains+are+responsible+for+the+antigenic+heterogeneity+of+the+O157%3AH-+strain+E32511.&rft.au=Schmitt%2C+C+K%3BMcKee%2C+M+L%3BO%27Brien%2C+A+D&rft.aulast=Schmitt&rft.aufirst=C&rft.date=1991-03-01&rft.volume=59&rft.issue=3&rft.spage=1065&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-02 N1 - Date created - 1991-04-02 N1 - Date revised - 2017-01-13 N1 - Gene symbol - slt-I; slt-II; slt-IIc; slt-IIv; vtx2ha; vtx2hb N1 - Genetic sequence - M59432; GENBANK N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1975 Mar;72(3):1184-8 [1055375] J Infect Dis. 1986 Aug;154(2):338-41 [3522760] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] J Mol Biol. 1979 Mar 25;129(1):169-72 [448736] Gene. 1980 Nov;11(3-4):291-8 [6260575] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] Anal Biochem. 1980 Dec;109(2):399-402 [7224165] Anal Biochem. 1981 Jun;114(1):193-7 [6269464] Infect Immun. 1982 Mar;35(3):1151-4 [7040247] Lancet. 1983 Jan 1;1(8314-5):76 [6129412] Lancet. 1983 Mar 19;1(8325):619-20 [6131302] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] Lancet. 1988 Sep 24;2(8613):751 [2901605] J Clin Microbiol. 1988 Oct;26(10):2127-31 [3053764] Microb Pathog. 1987 Jul;3(1):21-30 [3143036] Clin Microbiol Rev. 1989 Jan;2(1):15-38 [2644022] J Infect Dis. 1989 Feb;159(2):344-7 [2644374] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] J Gen Microbiol. 1987 May;133(5):1309-17 [3655740] Infect Immun. 1987 Nov;55(11):2675-80 [2822579] Epidemiol Infect. 1987 Dec;99(3):613-24 [3322851] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] J Med Microbiol. 1988 Jun;26(2):77-85 [3290494] Infect Immun. 1988 Aug;56(8):1926-33 [3294179] Gene. 1988 Oct 15;70(1):191-7 [2853689] Microb Pathog. 1989 Feb;6(2):113-22 [2654533] J Clin Microbiol. 1989 Sep;27(9):1973-8 [2674193] J Infect Dis. 1989 Dec;160(6):994-8 [2685131] Infect Immun. 1990 Mar;58(3):611-8 [2155181] Infect Immun. 1990 May;58(5):1232-9 [2182539] J Gen Microbiol. 1989 Aug;135(8):2307-18 [2699332] Microb Pathog. 1990 Jan;8(1):47-60 [2185397] Infect Immun. 1990 Aug;58(8):2438-45 [2196227] J Gen Microbiol. 1990 Jun;136(6):1125-35 [2200845] Arch Dis Child. 1990 Jul;65(7):716-21 [2201261] Arch Dis Child. 1990 Jul;65(7):722-7 [2201262] Infect Immun. 1990 Dec;58(12):3959-65 [2254023] N Engl J Med. 1983 Mar 24;308(12):681-5 [6338386] Lancet. 1983 Mar 26;1(8326 Pt 1):702 [6132054] Infect Immun. 1983 May;40(2):675-83 [6341244] Lancet. 1983 Sep 3;2(8349):573 [6136724] Gene. 1983 Dec;26(1):101-6 [6323249] Lancet. 1984 Jun 2;1(8388):1242-3 [6144957] Lancet. 1985 Oct 19;2(8460):885-6 [2864594] Infect Immun. 1985 Dec;50(3):695-700 [3905611] J Gen Microbiol. 1985 Nov;131(11):3047-53 [3005476] Br Med J (Clin Res Ed). 1986 Jun 7;292(6534):1513-6 [3087499] Infect Immun. 1986 Jul;53(1):135-40 [3522426] Infect Immun. 1977 Dec;18(3):775-9 [338490] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mapping the minimal contiguous gene segment that encodes functionally active Shiga-like toxin II. AN - 80454109; 1997433 AB - Shiga-like toxin type II (SLT-II) is one of two antigenically distinct cytotoxins produced by enterohemorrhagic Escherichia coli that are believed to play a central role in the pathogenesis of enterohemorrhagic E. coli-induced disease. SLT-II is a bipartite toxin with an enzymatically active A subunit that inhibits protein synthesis and an oligomeric B subunit that binds to the glycolipid globotriaosylceramide on eukaryotic cells. In this study, functional boundaries of the slt-II operon were mapped. Mutant proteins lacking the last four amino acids from the carboxy terminus of the 70-amino-acid mature SLT-II B polypeptide had no cytotoxic activity. However, when only two amino acids were removed from the carboxy terminus of the B subunit, the cytotoxic activity of the holotoxin was not altered drastically. Furthermore, a 21-amino-acid extension to the carboxy terminus of the SLT-II B polypeptide was tolerated with a minimum reduction in cytotoxic activity of the holotoxin. Deletion of the region coding for amino acids 3 through 18 of the 296-amino-acid mature SLT-II A polypeptide resulted in complete ablation of the cytotoxic activity of the holotoxin as well as abolition of the enzymatic activity of the A subunit. Thus, it appears that both 5'- and 3'-terminal coding sequences are essential for function of the slt-II operon. JF - Infection and immunity AU - Perera, L P AU - Samuel, J E AU - Holmes, R K AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 829 EP - 835 VL - 59 IS - 3 SN - 0019-9567, 0019-9567 KW - Bacterial Toxins KW - 0 KW - DNA, Bacterial KW - Oligonucleotide Probes KW - Shiga Toxin 2 KW - Endodeoxyribonucleases KW - EC 3.1.- KW - exonuclease Bal 31 KW - EC 3.1.11.- KW - Index Medicus KW - Protein Biosynthesis KW - Animals KW - Chromosome Deletion KW - HeLa Cells KW - Humans KW - Operon -- genetics KW - Amino Acid Sequence KW - Plasmids KW - Chromosome Mapping KW - Structure-Activity Relationship KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Molecular Sequence Data KW - Vero Cells KW - Chromatography, Thin Layer KW - Bacterial Toxins -- genetics KW - Genes, Bacterial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80454109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Mapping+the+minimal+contiguous+gene+segment+that+encodes+functionally+active+Shiga-like+toxin+II.&rft.au=Perera%2C+L+P%3BSamuel%2C+J+E%3BHolmes%2C+R+K%3BO%27Brien%2C+A+D&rft.aulast=Perera&rft.aufirst=L&rft.date=1991-03-01&rft.volume=59&rft.issue=3&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-02 N1 - Date created - 1991-04-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] J Bacteriol. 1990 Jun;172(6):3346-50 [2345150] N Engl J Med. 1983 Mar 24;308(12):681-5 [6338386] Lancet. 1983 Mar 26;1(8326 Pt 1):702 [6132054] Lancet. 1985 Oct 19;2(8460):885-6 [2864594] Infect Immun. 1986 Jul;53(1):135-40 [3522426] Gene. 1986;45(3):333-8 [3026919] J Biol Chem. 1987 Feb 5;262(4):1779-85 [3543013] J Biol Chem. 1987 Apr 15;262(11):5398-403 [3558397] J Biol Chem. 1987 Jun 25;262(18):8834-9 [3298243] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] Infect Immun. 1987 Nov;55(11):2675-80 [2822579] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] Methods Enzymol. 1987;154:367-82 [3323813] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2568-72 [3357883] J Med Microbiol. 1988 Jun;26(2):77-85 [3290494] Infect Immun. 1988 Aug;56(8):1926-33 [3294179] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] Gene. 1988 Jul 30;67(2):213-21 [3049254] J Clin Microbiol. 1988 Oct;26(10):2127-31 [3053764] Clin Microbiol Rev. 1989 Jan;2(1):15-38 [2644022] EMBO J. 1989 Jan;8(1):301-8 [2714255] J Biol Chem. 1989 Aug 25;264(24):14256-61 [2503515] Infect Immun. 1989 Dec;57(12):3743-50 [2807546] Mol Cell Biol. 1989 Nov;9(11):5012-21 [2689871] J Bacteriol. 1990 Feb;172(2):653-8 [2404947] Infect Immun. 1990 Mar;58(3):611-8 [2155181] Lancet. 1983 Jan 1;1(8314-5):76 [6129412] N1 - Last updated - 2017-01-17 ER - TY - CONF T1 - The 33rd SEAMEO-TROPMED Regional Seminar on Emerging Problems in Food-Borne Parasitic Zoonoses: Impact on Agriculture and Public Health. AN - 72476139; 1683009 JF - The Southeast Asian journal of tropical medicine and public health AU - Cross, J H AU - Murrell, K D Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 4 EP - 15 VL - 22 IS - 1 KW - Index Medicus KW - Animals KW - Humans KW - Asia, Southeastern KW - Agriculture -- economics KW - Zoonoses KW - Parasitic Diseases -- economics KW - Parasitic Diseases -- prevention & control KW - Food Parasitology KW - Public Health -- economics KW - Parasitic Diseases -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72476139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.atitle=The+33rd+SEAMEO-TROPMED+Regional+Seminar+on+Emerging+Problems+in+Food-Borne+Parasitic+Zoonoses%3A+Impact+on+Agriculture+and+Public+Health.&rft.au=Cross%2C+J+H%3BMurrell%2C+K+D&rft.aulast=Cross&rft.aufirst=J&rft.date=1991-03-01&rft.volume=22&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=The+Southeast+Asian+journal+of+tropical+medicine+and+public+health&rft.issn=01251562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-12-13 N1 - Date created - 1991-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Surface immunoglobulin crosslinking activates a tyrosine kinase pathway in B cells that is independent of protein kinase C. AN - 80449489; 1705033 AB - It has been found that the principal biochemical pathway activated in B cells stimulated by antigen- or anti-immunoglobulin-mediated crosslinking of surface immunoglobulin is that resulting in hydrolysis of phosphatidylinositol bisphosphate with generation of diacylglycerol and inositol trisphosphate. Recent evidence suggests that surface immunoglobulin-mediated B-cell activation can proceed without detectable increases in the concentration of either diacylglycerol or intracellular Ca2+ concentration, implicating involvement of other non-protein-kinase-C/Ca2(+)-dependent signal-transduction pathways. Therefore, we sought evidence for activation of a signaling pathway that is associated with growth regulation in other cell types--i.e., the protein-tyrosine kinases. We now show that crosslinking of membrane immunoglobulin by mitogenic antibodies leads to rapid tyrosine phosphorylation of several cellular substrates, consistent with the induction of a tyrosine kinase activity. This increase in tyrosine phosphorylation is weakly (if at all) stimulated by other B-cell mitogens, including phorbol esters and ionophores, and does not require the presence of detectable protein kinase C. Furthermore, inhibition of anti-immunoglobulin-stimulated phosphatidylinositol bisphosphate hydrolysis does not inhibit activation of this tyrosine kinase-dependent pathway. These findings suggest that occupancy of the membrane immunoglobulin receptor may induce multiple pathways of activation. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Brunswick, M AU - Samelson, L E AU - Mond, J J AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1991/02/15/ PY - 1991 DA - 1991 Feb 15 SP - 1311 EP - 1314 VL - 88 IS - 4 SN - 0027-8424, 0027-8424 KW - Antibodies, Monoclonal KW - 0 KW - Cross-Linking Reagents KW - Lipopolysaccharides KW - Phosphoproteins KW - Receptors, Antigen, B-Cell KW - Phosphotyrosine KW - 21820-51-9 KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Tyrosine KW - 42HK56048U KW - Ionomycin KW - 56092-81-0 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Animals KW - Lipopolysaccharides -- pharmacology KW - Ionomycin -- pharmacology KW - Mice KW - Tyrosine -- analysis KW - Mice, Inbred DBA KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Mice, Inbred Strains KW - Blotting, Western KW - Mice, Inbred C57BL KW - Spleen -- immunology KW - Tyrosine -- analogs & derivatives KW - Phosphoproteins -- isolation & purification KW - Male KW - Protein Kinase C -- metabolism KW - B-Lymphocytes -- drug effects KW - B-Lymphocytes -- immunology KW - Receptors, Antigen, B-Cell -- physiology KW - Protein-Tyrosine Kinases -- metabolism KW - B-Lymphocytes -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80449489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Surface+immunoglobulin+crosslinking+activates+a+tyrosine+kinase+pathway+in+B+cells+that+is+independent+of+protein+kinase+C.&rft.au=Brunswick%2C+M%3BSamelson%2C+L+E%3BMond%2C+J+J&rft.aulast=Brunswick&rft.aufirst=M&rft.date=1991-02-15&rft.volume=88&rft.issue=4&rft.spage=1311&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-27 N1 - Date created - 1991-03-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Immunol. 1988 Apr 1;112(2):329-42 [3281760] Immunol Rev. 1983;74:29-56 [6195085] Proc Natl Acad Sci U S A. 1989 Sep;86(17):6724-8 [2549544] J Immunol. 1989 Sep 1;143(5):1414-21 [2474595] Biochem Biophys Res Commun. 1985 Aug 30;131(1):484-91 [2994665] J Immunol. 1986 Jul 15;137(2):708-14 [3014002] J Immunol. 1987 Aug 15;139(4):1054-9 [3038996] J Immunol. 1987 Jun 1;138(11):3935-42 [3035017] Eur J Immunol. 1988 Nov;18(11):1811-7 [3144454] Cold Spring Harb Symp Quant Biol. 1988;53 Pt 1:131-42 [3076078] Anal Biochem. 1988 Jul;172(1):1-7 [2461110] Proc Natl Acad Sci U S A. 1988 Jul;85(14):5190-4 [2455897] J Immunol. 1988 May 15;140(10):3364-72 [2452184] Oncogene. 1988 Apr;2(4):305-15 [2452398] J Immunol. 1986 Apr 1;136(7):2382-92 [2419432] Nature. 1984 Apr 19-25;308(5961):693-8 [6232463] J Immunol. 1984 Feb;132(2):787-95 [6690619] J Immunol. 1980 Sep;125(3):1066-70 [6774013] J Immunol. 1981 Nov;127(5):1953-8 [6975305] J Exp Med. 1980 Jul 1;152(1):138-50 [6967509] Immunol Rev. 1979;47:63-90 [398327] Biochem J. 1975 Jan;146(1):247-52 [167716] Cell. 1985 Jul;41(3):999-1006 [2408764] Nature. 1989 Mar 16;338(6212):257-9 [2784195] J Biol Chem. 1989 Jun 25;264(18):10836-42 [2786526] Cell. 1988 Oct 21;55(2):301-8 [3262426] Nature. 1984 Nov 22-28;312(5992):315-21 [6095092] J Immunol. 1984 Nov;133(5):2333-42 [6207226] Proc Natl Acad Sci U S A. 1987 Dec;84(23):8588-92 [3500475] Eur J Immunol. 1986 Jan;16(1):92-7 [3485050] Cell Immunol. 1986 Oct 15;102(2):364-73 [3492280] Hybridoma. 1982;1(2):125-31 [6821397] Science. 1990 Mar 30;247(4950):1584-7 [2138816] J Immunol. 1990 Jan 15;144(2):451-5 [2153169] Nature. 1990 Jun 28;345(6278):810-3 [1694265] Eur J Immunol. 1990 Apr;20(4):855-61 [1693337] J Immunol. 1990 Mar 1;144(5):1591-9 [1689750] Proc Natl Acad Sci U S A. 1990 Jun;87(11):4358-62 [2190221] Science. 1990 Jan 19;247(4940):332-6 [2404338] EMBO J. 1990 Jul;9(7):2125-31 [2357961] Cell Immunol. 1987 Sep;108(2):473-82 [2957071] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Internal maxillary artery variability in the pterygopalatine fossa. AN - 85203661; pmid-1901148 AB - The third segment or pterygopalatine branch of the internal maxillary artery has variable branching in the pterygopalatine fossa. This variability in branching can lead to failure in controlling persistent nasal epistaxis by transantral ligation. Although the surgical approach has been previously studied, a systematic classification of this branching has not been previously reported. Through the performance of serial cadaver dissections in the PPF, we have demonstrated the anatomic course and variations of this third segment and offer a relatively simple classification system. JF - Otolaryngology--Head and Neck Surgery AU - Morton, A L AU - Khan, A AD - Department of Otolaryngology-Head and Neck Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD. PY - 1991 SP - 204 EP - 209 VL - 104 IS - 2 SN - 0194-5998, 0194-5998 KW - Maxillary Sinus KW - Orbit KW - Arteries KW - Human KW - Maxillary Artery KW - Sphenoid Bone KW - Adipose Tissue KW - Palate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85203661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Internal+maxillary+artery+variability+in+the+pterygopalatine+fossa.&rft.au=Morton%2C+A+L%3BKhan%2C+A&rft.aulast=Morton&rft.aufirst=A&rft.date=1991-02-01&rft.volume=104&rft.issue=2&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Identification of three amino acid residues in the B subunit of Shiga toxin and Shiga-like toxin type II that are essential for holotoxin activity. AN - 80431443; 1991714 AB - Shiga toxin of Shigella dysenteriae type I and Shiga-like toxins I and II (SLT-I and SLT-II, respectively) of enterohemorrhagic Escherichia coli are functionally similar protein cytotoxins. These toxin molecules have a bipartite molecular structure which consists of an enzymatically active A subunit that inhibits protein synthesis in eukaryotic cells and an oligomeric B subunit that binds to globotriaosylceramide glycolipid receptors on eukaryotic cells. Regionally directed chemical mutagenesis of the B subunit of SLT-II was used to identify amino acids in the B subunit that are critical for SLT-II holotoxin cytotoxic activity. Three noncytotoxic mutants were isolated, and their mutations were mapped. The substitutions of arginine with cysteine at codon 32, alanine with threonine at codon 42, and glycine with aspartic acid at codon 59 in the 70-amino-acid mature SLT-II B polypeptide resulted in the complete abolition of cytotoxicity. The analogous arginine, alanine, and glycine residues were conserved at codons 33, 43, and 60 in the 69-amino-acid mature B polypeptide of Shiga toxin. Comparable mutations induced in the B-subunit gene of Shiga toxin by oligonucleotide-directed, site-specific mutagenesis resulted in drastically decreased cytotoxicity (10(3)- to 10(6)-fold) as compared with that of wild-type Shiga toxin. The mutant SLT-II and Shiga toxin B subunits were characterized for stability, receptor binding, immunoreactivity, and ability to be assembled into holotoxin. JF - Journal of bacteriology AU - Perera, L P AU - Samuel, J E AU - Holmes, R K AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 1151 EP - 1160 VL - 173 IS - 3 SN - 0021-9193, 0021-9193 KW - Amino Acids KW - 0 KW - Bacterial Toxins KW - Cytotoxins KW - Mutagens KW - Shiga Toxin 2 KW - Shiga Toxins KW - Sulfites KW - sodium bisulfite KW - TZX5469Z6I KW - Index Medicus KW - Animals KW - Sulfites -- pharmacology KW - HeLa Cells KW - Humans KW - Mice KW - Rabbits KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Molecular Sequence Data KW - Enzyme-Linked Immunosorbent Assay KW - Vero Cells KW - Chromatography, Thin Layer KW - Fluorescent Antibody Technique KW - Bacterial Toxins -- genetics KW - Escherichia coli -- metabolism KW - Cytotoxins -- chemistry KW - Cytotoxins -- metabolism KW - Bacterial Toxins -- metabolism KW - Cytotoxins -- toxicity KW - Amino Acids -- chemistry KW - Escherichia coli -- genetics KW - Cytotoxins -- genetics KW - Bacterial Toxins -- chemistry KW - Bacterial Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80431443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Identification+of+three+amino+acid+residues+in+the+B+subunit+of+Shiga+toxin+and+Shiga-like+toxin+type+II+that+are+essential+for+holotoxin+activity.&rft.au=Perera%2C+L+P%3BSamuel%2C+J+E%3BHolmes%2C+R+K%3BO%27Brien%2C+A+D&rft.aulast=Perera&rft.aufirst=L&rft.date=1991-02-01&rft.volume=173&rft.issue=3&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-11 N1 - Date created - 1991-03-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 1986 Jun 1;163(6):1391-404 [3519828] Infect Immun. 1990 Mar;58(3):611-8 [2155181] J Biol Chem. 1987 Feb 5;262(4):1779-85 [3543013] Science. 1987 Jun 5;236(4806):1252-8 [3296192] J Biol Chem. 1987 Jun 25;262(18):8834-9 [3298243] Infect Immun. 1987 Nov;55(11):2675-80 [2822579] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] Methods Enzymol. 1987;154:367-82 [3323813] J Bacteriol. 1979 Jan;137(1):692-3 [368040] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] J Mol Biol. 1981 May 5;148(1):45-62 [6273577] Infect Immun. 1983 Jul;41(1):430-3 [6345399] Methods Enzymol. 1983;100:457-68 [6312263] Infect Immun. 1985 Dec;50(3):695-700 [3905611] J Infect Dis. 1986 Feb;153(2):238-48 [3003205] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] J Infect Dis. 1988 May;157(5):1023-31 [3283253] Infect Immun. 1988 Jun;56(6):1618-24 [3286503] Infect Immun. 1988 Aug;56(8):1926-33 [3294179] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] J Clin Microbiol. 1988 Oct;26(10):2127-31 [3053764] J Biol Chem. 1989 May 5;264(13):7596-602 [2651443] Biochem Biophys Res Commun. 1989 Apr 14;160(1):126-32 [2653314] J Immunol Methods. 1989 Sep 29;123(1):9-18 [2507644] Mol Microbiol. 1989 Sep;3(9):1231-6 [2677606] Infect Immun. 1989 Dec;57(12):3743-50 [2807546] J Infect Dis. 1990 Jan;161(1):134-7 [2295845] J Bacteriol. 1990 Feb;172(2):653-8 [2404947] Infect Immun. 1986 Jul;53(1):135-40 [3522426] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin. AN - 80418438; 1899070 AB - We have studied the cytotoxicity of ricin in cells treated with brefeldin A (BFA), which dramatically disrupts the structure of the Golgi apparatus causing Golgi content and membrane to redistribute to the ER. BFA inhibits the cytotoxicity of ricin in Chinese hamster ovary, normal rat kidney, and Vero cells and abolishes the enhancement of ricin cytotoxicity by NH4Cl, nigericin, swainsonine, and tunicamycin or by a mutation in endosomal acidification. BFA protects cells from the cytotoxicities of modeccin and Pseudomonas toxin, but has no effect on the intoxication by diphtheria toxin. Pretreatment of BFA does not protect cells from ricin treatment in the absence of BFA. Our results suggest that ricin, modeccin, and Pseudomonas toxin share a common pathway of intracellular transport from endosomes to the Golgi region where they are released into the cytosol. In contrast, the lack of protection of Vero cells from diphtheria toxin by BFA indicates that diphtheria toxin is released from acidified endosomes without involving the Golgi region. JF - Experimental cell research AU - Yoshida, T AU - Chen, C C AU - Zhang, M S AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991/02// PY - 1991 DA - February 1991 SP - 389 EP - 395 VL - 192 IS - 2 SN - 0014-4827, 0014-4827 KW - Alkaloids KW - 0 KW - Bacterial Toxins KW - Cyclopentanes KW - Cytotoxins KW - Exotoxins KW - Lectins KW - Plant Lectins KW - Ribosome Inactivating Proteins, Type 2 KW - Virulence Factors KW - Ammonium Chloride KW - 01Q9PC255D KW - Tunicamycin KW - 11089-65-9 KW - Brefeldin A KW - 20350-15-6 KW - modeccin KW - 65988-88-7 KW - Ricin KW - 9009-86-3 KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Swainsonine KW - RSY4RK37KQ KW - Index Medicus KW - Animals KW - Exotoxins -- pharmacology KW - Tunicamycin -- pharmacology KW - Ammonium Chloride -- pharmacology KW - Ricin -- pharmacology KW - Lectins -- pharmacology KW - Ricin -- metabolism KW - Kinetics KW - Endocytosis -- drug effects KW - Alkaloids -- pharmacology KW - Mutation KW - Cell Line KW - Cyclopentanes -- pharmacology KW - Golgi Apparatus -- drug effects KW - Cytotoxins -- antagonists & inhibitors KW - Cytotoxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80418438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Disruption+of+the+Golgi+apparatus+by+brefeldin+A+inhibits+the+cytotoxicity+of+ricin%2C+modeccin%2C+and+Pseudomonas+toxin.&rft.au=Yoshida%2C+T%3BChen%2C+C+C%3BZhang%2C+M+S%3BWu%2C+H+C&rft.aulast=Yoshida&rft.aufirst=T&rft.date=1991-02-01&rft.volume=192&rft.issue=2&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-25 N1 - Date created - 1991-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effects of nicotine on the acoustic startle reflex amplitude in rats. AN - 85255904; pmid-1876669 AB - The acoustic startle reflex was used to measure changes in sensorimotor reactivity in response to nicotine administration and cessation. Male rats received saline, 6 mg/kg/day or 12 mg/kg/day nicotine delivered subcutaneously by osmotic minipumps. The pumps delivered their contents during a 10-day period of implantation, after which time they were explanted. Animals were tested for startle reflex amplitudes using two levels of white noise bursts prior to pump implantation, on days 1 and 7 of nicotine or saline administration, and on several days following drug cessation. Nicotine produced a dose-dependent increase in startle amplitude during the period of administration that decreased during cessation. Results are interpreted in terms of nicotine's actions to enhance attentional processes. JF - Psychopharmacology AU - Acri, J B AU - Grunberg, N E AU - Morse, D E AD - Department of Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. PY - 1991 SP - 244 EP - 248 VL - 104 IS - 2 SN - 0033-3158, 0033-3158 KW - Rats KW - Rats, Inbred Strains KW - Startle Reaction KW - Dose-Response Relationship, Drug KW - Nicotine KW - Animal KW - Support, U.S. Gov't, Non-P.H.S. KW - Acoustic Stimulation KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85255904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Effects+of+nicotine+on+the+acoustic+startle+reflex+amplitude+in+rats.&rft.au=Acri%2C+J+B%3BGrunberg%2C+N+E%3BMorse%2C+D+E&rft.aulast=Acri&rft.aufirst=J&rft.date=1991-01-01&rft.volume=104&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Diltiazem increases late-onset congestive heart failure in postinfarction patients with early reduction in ejection fraction. The Adverse Experience Committee; and the Multicenter Diltiazem Postinfarction Research Group. AN - 80364287; 1984898 AB - The Multicenter Diltiazem Postinfarction Trial (MDPIT) reported no consistent diltiazem effect on new or worsened congestive heart failure (CHF) during 12-52 months' follow-up after acute myocardial infarction. This was puzzling in light of the observation that patients with findings suggesting left ventricular dysfunction (LVD) at baseline on diltiazem had more cardiac events (cardiac mortality or recurrent nonfatal infarction) than such patients on placebo. We hypothesized that diltiazem increased the frequency of late CHF as well as of cardiac events, but only in patients predisposed by LVD. Using the same characterizing variables as the primary MDPIT analysis, we found that patients with pulmonary congestion, anterolateral Q wave infarction, or reduced ejection fraction (EF) at baseline were more likely to have CHF during follow-up than those without these markers of LVD. CHF was particularly frequent in the patients with LVD who were randomized to diltiazem. Among those with a baseline EF of less than 0.40, late CHF appeared in 12% (39/326) receiving placebo and 21% (61/297) receiving diltiazem (p = 0.004). Life table analysis in patients with an EF of less than 0.40 confirmed more frequent late CHF in those taking diltiazem (p = 0.0017). In addition, the diltiazem-associated rise in the frequency of late CHF was progressively greater with increasingly severe decrements in baseline EF. This diltiazem effect was absent in patients with pulmonary congestion at baseline but an EF of 0.40 or more, suggesting a unique association between diltiazem-related late CHF and systolic LVD.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Circulation AU - Goldstein, R E AU - Boccuzzi, S J AU - Cruess, D AU - Nattel, S AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md. 20814-4799. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 52 EP - 60 VL - 83 IS - 1 SN - 0009-7322, 0009-7322 KW - Diltiazem KW - EE92BBP03H KW - Abridged Index Medicus KW - Index Medicus KW - Life Tables KW - Double-Blind Method KW - Humans KW - Ventricular Function, Left -- physiology KW - Follow-Up Studies KW - Stroke Volume -- physiology KW - Heart Failure -- epidemiology KW - Heart Failure -- chemically induced KW - Diltiazem -- therapeutic use KW - Myocardial Infarction -- drug therapy KW - Diltiazem -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80364287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Diltiazem+increases+late-onset+congestive+heart+failure+in+postinfarction+patients+with+early+reduction+in+ejection+fraction.+The+Adverse+Experience+Committee%3B+and+the+Multicenter+Diltiazem+Postinfarction+Research+Group.&rft.au=Goldstein%2C+R+E%3BBoccuzzi%2C+S+J%3BCruess%2C+D%3BNattel%2C+S&rft.aulast=Goldstein&rft.aufirst=R&rft.date=1991-01-01&rft.volume=83&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=00097322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-04 N1 - Date created - 1991-02-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Circulation. 1991 Jan;83(1):336-8 [1984891] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Emergency department approach to managing seizures in pregnancy. AN - 80363698; 1984736 AB - Seizures in pregnancy pose risks for both the mother and the fetus and must be managed aggressively. Antiepileptic drugs have some teratogenic potential, but the risks are not as profound as reported in earlier literature. There is definitely less risk to the fetus from anticonvulsant exposure than from uncontrolled seizures. The evaluation of a pregnant woman with new-onset seizures is the same as for the nonpregnant patient, including head computed tomography with appropriate abdominal shielding. Status epilepticus management is based on IV benzodiazepines, phenytoin, or phenobarbital. Good fetal outcome is dependent on rapid seizure control. Management of eclampsia is controversial. There is little evidence that magnesium sulfate has anticonvulsant properties, and its use as such will probably decline steadily in the future. At present, it is reasonable to manage eclamptic seizures in the same way that status epilepticus is managed. JF - Annals of emergency medicine AU - Jagoda, A AU - Riggio, S AD - Division of Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 80 EP - 85 VL - 20 IS - 1 SN - 0196-0644, 0196-0644 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Eclampsia -- drug therapy KW - Female KW - Pregnancy KW - Emergency Medical Services -- methods KW - Pregnancy Complications -- therapy KW - Epilepsy -- therapy KW - Seizures -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80363698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+emergency+medicine&rft.atitle=Emergency+department+approach+to+managing+seizures+in+pregnancy.&rft.au=Jagoda%2C+A%3BRiggio%2C+S&rft.aulast=Jagoda&rft.aufirst=A&rft.date=1991-01-01&rft.volume=20&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Annals+of+emergency+medicine&rft.issn=01960644&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-31 N1 - Date created - 1991-01-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Emerg Med. 1991 Nov;20(11):1277 [1952321] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Methadone maintenance and clonidine detoxification in the treatment of opiate addicts in Israel: suggesting evidence for cultural differences in the effectiveness of treatment modalities for opiate addiction. AN - 72677803; 1666067 AB - A 13-month longitudinal study examined two treatment programs in Israel: Methadone Maintenance (MM) with adjunct psychotherapy, and Clonidine Detoxification (CD) with adjunct psychotherapy and antidepressants. A lower 3-month drop-out rate was found in the CD clinic in comparison to the MM clinic. After 13 months of treatment, approximately 50% of the patients in the treatment groups relapsed to heroin and the rest were either drug-free (in the CD clinic) or mainly maintained on methadone (in the MM clinic). No significant differences were observed in employment status, patient attitudes toward their therapists, and patient and therapist attitudes toward their respective treatment modalities. The effectiveness of these two treatment modalities was further compared to results obtained in the United States and other western countries. The results indicate that MM is less effective in Israel than in the United States. No clear-cut conclusion concerning the relative efficacy of CD treatment in Israel in comparison to other western countries can be inferred. The pattern of heroin use among heroin addicts, the popularity of methadone as an illegal drug in Israel, and the application of MM treatment modality in Israel may explain these results. JF - The Israel journal of psychiatry and related sciences AU - ShahamY AU - Shufman AU - Scher AU - Barel AU - Zlotogorski AU - Cohen AD - Medical Psychology Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1991 PY - 1991 DA - 1991 SP - 45 EP - 57 VL - 28 IS - 3 SN - 0333-7308, 0333-7308 KW - Antidepressive Agents KW - 0 KW - Clonidine KW - MN3L5RMN02 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - United States KW - Substance Abuse Treatment Centers KW - Psychotherapy KW - Combined Modality Therapy KW - Patient Dropouts KW - Cross-Cultural Comparison KW - Heroin Dependence -- rehabilitation KW - Antidepressive Agents -- therapeutic use KW - Israel KW - Employment KW - Longitudinal Studies KW - Recurrence KW - Culture KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Clonidine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72677803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Israel+journal+of+psychiatry+and+related+sciences&rft.atitle=Methadone+maintenance+and+clonidine+detoxification+in+the+treatment+of+opiate+addicts+in+Israel%3A+suggesting+evidence+for+cultural+differences+in+the+effectiveness+of+treatment+modalities+for+opiate+addiction.&rft.au=ShahamY%3BShufman%3BScher%3BBarel%3BZlotogorski%3BCohen&rft.aulast=ShahamY&rft.aufirst=&rft.date=1991-01-01&rft.volume=28&rft.issue=3&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=The+Israel+journal+of+psychiatry+and+related+sciences&rft.issn=03337308&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-17 N1 - Date created - 1992-04-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Isr J Psychiatry Relat Sci. 1992;29(2):128-30 [1526758] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - International Monterey colloquium on Deep convection and deep water formation in the oceans AN - 50355564; 1993-011454 JF - Elsevier Oceanography Series A2 - Chu, P. C. A2 - Gascard, Jean-Claude Y1 - 1991 PY - 1991 DA - 1991 SP - 382 PB - Elsevier, Amsterdam VL - 57 SN - 0422-9894, 0422-9894 KW - ocean circulation KW - symposia KW - marine environment KW - deep-sea environment KW - convection KW - oceanography KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50355564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Elsevier+Oceanography+Series&rft.atitle=International+Monterey+colloquium+on+Deep+convection+and+deep+water+formation+in+the+oceans&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-01-01&rft.volume=57&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Elsevier+Oceanography+Series&rft.issn=04229894&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - International Monterey colloquium on Deep convection and deep water formation in the oceans N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Document feature - illus. incl. sketch map N1 - SuppNotes - Individual papers are not cited separately N1 - Last updated - 2012-06-07 N1 - CODEN - ELOSA9 N1 - SubjectsTermNotLitGenreText - convection; deep-sea environment; marine environment; ocean circulation; oceanography; symposia ER - TY - JOUR T1 - The pH dependence of transient changes in the curvature of the purple membrane. AN - 16254924; 2778096 AB - We have observed transient changes in the curvature of purple membrane fragments upon photoexcitation as a function of the pH of the suspending medium. The room temperature suspensions have low ionic strengths, and the bending is observed by changes in the scattered light at 320 nm. The photoexcitation is from a 20 ns laser pulse at 532 nm. We use a simple first-order approximation to subtract any changes in the scattered light associated with transient adsorption changes during the photocycle. The resultant scattering curves are then fitted to the sum of three fundamental bending processes. Each process has an exponential rise, an exponential decay and an amplitude. We model two of the processes as transient forces correlated with the charge motion during the photocycle. The third process is probably caused by local changes of the pH as the protein pumps protons. JF - Photochemistry and Photobiology AU - Czege, J AU - Reinisch, L AD - Laser Biophys. Cent., USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20899, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 923 EP - 930 VL - 54 IS - 6 SN - 0031-8655, 0031-8655 KW - Halobacterium halobium KW - U.V. spectroscopy KW - conformation KW - light scattering KW - mathematical models KW - pH KW - purple membranes KW - Biochemistry Abstracts 1: Biological Membranes (till 1993); Microbiology Abstracts B: Bacteriology KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16254924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+Photobiology&rft.atitle=The+pH+dependence+of+transient+changes+in+the+curvature+of+the+purple+membrane.&rft.au=Czege%2C+J%3BReinisch%2C+L&rft.aulast=Czege&rft.aufirst=J&rft.date=1991-01-01&rft.volume=54&rft.issue=6&rft.spage=923&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+Photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Halobacterium halobium; U.V. spectroscopy; purple membranes; pH; light scattering; mathematical models; conformation ER - TY - JOUR T1 - Central ventilatory effects of thyrotropin-releasing hormone in the conscious rat. AN - 16016384; 2590906 AB - We investigated the effect of TRH on ventilation rate, relative tidal volume, relative respiratory minute volume, CO sub(2) production CO sub(2) consumption, and locomotor activity in the conscious, unrestrained rat. Intracerebroventricular application of TRH induced a dose-dependent, sustained increase in ventilation rate, relative tidal volume, and relative respiratory minute volume of maximally 128%, 890%, and 235%, respectively. In addition, CO sub(2) production and O sub(2) consumption were elevated by 4.6 and 11.7 fold, while no significant changes in locomotor activity were observed. The results suggest that TRH stimulates ventilation by a mechanism independent of its analeptic properties. JF - Neuropeptides AU - Vonhof, S AU - Siren, A-L AU - Feuerstein, G Z AD - Dep. Neurol., USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20889-4799, USA Y1 - 1991 PY - 1991 DA - 1991 SP - 93 EP - 98 VL - 18 IS - 2 SN - 0143-4179, 0143-4179 KW - effects on KW - intracerebroventricular administration KW - locomotor activity KW - rats KW - stimulation KW - thyroid-hormone releasing-hormone KW - ventilation KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - N3 11080:Neuroendocrinology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16016384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropeptides&rft.atitle=Central+ventilatory+effects+of+thyrotropin-releasing+hormone+in+the+conscious+rat.&rft.au=Vonhof%2C+S%3BSiren%2C+A-L%3BFeuerstein%2C+G+Z&rft.aulast=Vonhof&rft.aufirst=S&rft.date=1991-01-01&rft.volume=18&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Neuropeptides&rft.issn=01434179&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - locomotor activity; ventilation ER - TY - JOUR T1 - Extremal wave statistics using three hindcasts AN - 13737605; S199137139 AB - Deep-water design wave estimates for Monterey bay, California, were calculated on the basis of extreme wave statistics from 3 different databases containing deep-water wave data for the central California coast region. Significant wave heights were fitted to 2 probability distributions, the Fisher Tippet (type I) and the Weibull (type III), to obtain the design estimates. Fifty- and 100-year significant wave-height estimates, together with distribution and sampling parameters were used to compare the data-sets. The U.S. Navy spectral ocean wave model data appeared to overestimated the extreme wave statistics, while similar design-wave heights were predicted by U.S. Army Corps of Engineers and Pacific Weather Analysis model data. JF - Journal of Waterway, Port, Coastal and Ocean Engineering AU - Wyland, R M AU - Thornton, E B AD - Naval Postgraduate School, Monterey, Calif. Y1 - 1991 PY - 1991 DA - 1991 SP - 60 EP - 74 VL - 117 IS - 1 SN - 0733-950X, 0733-950X KW - Modelling (-general-) KW - Navy KW - Sea water (see also marine -----) KW - Aqualine Abstracts KW - AQ 00001:Water Resources and Supplies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13737605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Waterway%2C+Port%2C+Coastal+and+Ocean+Engineering&rft.atitle=Extremal+wave+statistics+using+three+hindcasts&rft.au=Wyland%2C+R+M%3BThornton%2C+E+B&rft.aulast=Wyland&rft.aufirst=R&rft.date=1991-01-01&rft.volume=117&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Journal+of+Waterway%2C+Port%2C+Coastal+and+Ocean+Engineering&rft.issn=0733950X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Analytical modelling of aquifer decontamination by pumping when transport is affected by rate-limited sorption AN - 13731641; S199238567 AB - An analytical model is described which accounted for rate-limited desorption of an organic solute during cleanup at a contaminated site. Model equations describing transport of a sorbing contaminant in a converging radial flow field and equilibrium, first-order rate and Fickian diffusion expressions to describe sorption, were solved using Laplace domain analysis and numerically inverted to simulate contaminant concentrations at an extraction well. A Laplace domain solution for the total contaminant mass remaining in the aquifer was also derived. Rate-limited sorption could significantly effect aquifer remediation. The various rate-limited models were approximately equivalent. There are 34 references. JF - Water Resources Research AU - Goltz, M N AU - Oxley, ME AD - Air Force Institute of Technology, Ohio Y1 - 1991 PY - 1991 DA - 1991 SP - 547 EP - 556 VL - 27 IS - 4 SN - 0043-1397, 0043-1397 KW - Analysis KW - Modelling (-general-) KW - Aqualine Abstracts KW - AQ 00001:Water Resources and Supplies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13731641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Research&rft.atitle=Analytical+modelling+of+aquifer+decontamination+by+pumping+when+transport+is+affected+by+rate-limited+sorption&rft.au=Goltz%2C+M+N%3BOxley%2C+ME&rft.aulast=Goltz&rft.aufirst=M&rft.date=1991-01-01&rft.volume=27&rft.issue=4&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Research&rft.issn=00431397&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Theoretical. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - The inflammatory actions of platelet activating factor are blocked by levorotatory terbutaline. AN - 80364925; 1965987 AB - Platelet activating factor (PAF), a potent vasoactive lipid, may play an important role in the inflammatory process. In this study, we infused PAF intra-arterially to characterize its edematogenic potency in the canine forelimb. We have also assessed the ability of the beta 2-receptor agonist l-terbutaline to block PAF-mediated edema formation. The infusion of PAF at .25 micrograms/min, .5 micrograms/min and 1 micrograms/min increased forelimb arterial pressures and, at the two higher dosages, significantly decreased systemic arterial pressure. PAF infusions increased transvascular fluid and macromolecular flux as indicated by significant increases in skin lymph flow, protein concentration and protein transport. The intra-arterial infusion of l-terbutaline at 1 micrograms/min significantly decreased forelimb arterial pressures but did not affect small vein pressure, systemic pressure or forelimb lymph parameters. The subsequent infusion of PAF at .5 micrograms/min, during the continued infusion of l-terbutaline, failed to significantly affect forelimb lymph parameters. These data indicate that PAF is significantly more potent as an edematogenic agent in the forelimb than histamine or bradykinin. Furthermore, the blockade of PAF-mediated edema formation by l-terbutaline suggests that beta 2-receptor agonists may be capable of antagonizing the inflammatory actions of a wide variety of putative inflammatory mediators. JF - Microcirculation, endothelium, and lymphatics AU - Dobbins, D E AU - Buehn, M J AU - Dabney, J M AD - Department of Physiology Uniformed Services University of the Health Sciences Bethesda, Maryland 20814-4799. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 437 EP - 455 VL - 6 IS - 6 SN - 0740-9451, 0740-9451 KW - Platelet Activating Factor KW - 0 KW - Receptors, Adrenergic, beta KW - Histamine KW - 820484N8I3 KW - Terbutaline KW - N8ONU3L3PG KW - Bradykinin KW - S8TIM42R2W KW - Index Medicus KW - Edema -- chemically induced KW - Animals KW - Lymph -- chemistry KW - Edema -- prevention & control KW - Histamine -- pharmacology KW - Injections, Intra-Arterial KW - Dogs KW - Receptors, Adrenergic, beta -- physiology KW - Receptors, Adrenergic, beta -- drug effects KW - Bradykinin -- pharmacology KW - Molecular Conformation KW - Blood Pressure -- drug effects KW - Platelet Activating Factor -- antagonists & inhibitors KW - Inflammation -- prevention & control KW - Platelet Activating Factor -- toxicity KW - Lymphatic System -- drug effects KW - Inflammation -- chemically induced KW - Terbutaline -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80364925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microcirculation%2C+endothelium%2C+and+lymphatics&rft.atitle=The+inflammatory+actions+of+platelet+activating+factor+are+blocked+by+levorotatory+terbutaline.&rft.au=Dobbins%2C+D+E%3BBuehn%2C+M+J%3BDabney%2C+J+M&rft.aulast=Dobbins&rft.aufirst=D&rft.date=1990-12-01&rft.volume=6&rft.issue=6&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Microcirculation%2C+endothelium%2C+and+lymphatics&rft.issn=07409451&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-08 N1 - Date created - 1991-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Reversal of intracellular toxicity of the trichothecene mycotoxin T-2 with monoclonal antibody. AN - 80183604; 2262901 AB - The trichothecene mycotoxin T-2 is a potent inhibitor of intracellular protein synthesis. We have previously shown that a mouse immunoglobulin G1 monoclonal antibody (15H6) specific for T-2 toxin can neutralize the in vitro protein synthesis inhibitory effect of the toxin in human B-lymphoblastoid cultures, and protect rats from lethal toxemia. We now report that these monoclonal antibodies can induce the net efflux of [3H]-T-2 toxin from poisoned human B-lymphoblastoid cells in vitro, and restore protein synthesis. Administration of the monoclonal antibodies (250 mg/kg) 30 min before infusion of a lethal dose (1 mg/kg) of T-2 toxin causes the sequestration of the toxin in the plasma compartment. When administered 35 min after T-2 toxin, a time when the bulk of toxin is in the tissues, the monoclonal antibodies facilitate the migration of toxin back into the plasma compartment. These data demonstrate that monoclonal antibodies can be of therapeutic value against an intracellular toxin. JF - The Journal of pharmacology and experimental therapeutics AU - Hunter, K W AU - Brimfield, A A AU - Knower, A T AU - Powell, J A AU - Feuerstein, G Z AD - Department of Pediatrics, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 1183 EP - 1187 VL - 255 IS - 3 SN - 0022-3565, 0022-3565 KW - Antibodies, Monoclonal KW - 0 KW - Antitoxins KW - T-2 Toxin KW - I3FL5NM3MO KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Antitoxins -- pharmacology KW - Protein Biosynthesis KW - Animals KW - Antitoxins -- therapeutic use KW - Mice KW - Drug Synergism KW - Time Factors KW - Male KW - T-2 Toxin -- pharmacokinetics KW - Intracellular Fluid -- metabolism KW - Intracellular Fluid -- drug effects KW - Antibodies, Monoclonal -- pharmacology KW - T-2 Toxin -- toxicity KW - T-2 Toxin -- immunology KW - T-2 Toxin -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80183604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Reversal+of+intracellular+toxicity+of+the+trichothecene+mycotoxin+T-2+with+monoclonal+antibody.&rft.au=Hunter%2C+K+W%3BBrimfield%2C+A+A%3BKnower%2C+A+T%3BPowell%2C+J+A%3BFeuerstein%2C+G+Z&rft.aulast=Hunter&rft.aufirst=K&rft.date=1990-12-01&rft.volume=255&rft.issue=3&rft.spage=1183&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-07 N1 - Date created - 1991-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. AN - 80176413; 2259385 AB - Tumour suppressor genes, whose usual function seems to be controlling normal cell proliferation, have been implicated in many inherited and sporadic forms of malignancies Much evidence supports the concept of tumour formation by loss-of-function mutations in suppressor genes, as predicted by the two-hit model of Knudson and DeMars. The suppressor gene, p53, is affected in such a manner by numerous mutations, which occur in a variety of human tumours. These mutations usually represent the loss of one allele and the substitution of a single base in the other. We have now analysed the p53 gene in a family affected by Li-Fraumeni syndrome, a rare autosomal dominant syndrome characterized by the occurrence of diverse mesenchymal and epithelial neoplasms at multiple sites. In some instances the neoplasms seem to be related to exposure to carcinogens, including ionizing radiation. The Li-Fraumeni family that we studied had noncancerous skin fibroblasts (NSF) with an unusual radiation-resistant phenotype. DNA derived from the NSF cells of four family members, spanning two generations, had the same point mutation in codon 245 (GGC----GAC) of the p53 gene. This mutation leads to substitution of aspartic acid for glycine in one of the regions identified as a frequent target of point mutations in p53. The NSF cell lines with the mutation also retained the normal p53 allele. This inherited p53 mutation may predispose the members of this family to increased susceptibility to cancer. JF - Nature AU - Srivastava, S AU - Zou, Z Q AU - Pirollo, K AU - Blattner, W AU - Chang, E H AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. PY - 1990 SP - 747 EP - 749 VL - 348 IS - 6303 SN - 0028-0836, 0028-0836 KW - p53 KW - Codon KW - 0 KW - DNA, Neoplasm KW - Index Medicus KW - Phenotype KW - Polymerase Chain Reaction KW - Base Sequence KW - Humans KW - Fibroblasts -- chemistry KW - Molecular Sequence Data KW - DNA, Neoplasm -- genetics KW - Fibroblasts -- radiation effects KW - Male KW - Female KW - Germ Cells KW - Neoplastic Syndromes, Hereditary -- genetics KW - Genes, p53 KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80176413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Germ-line+transmission+of+a+mutated+p53+gene+in+a+cancer-prone+family+with+Li-Fraumeni+syndrome.&rft.au=Srivastava%2C+S%3BZou%2C+Z+Q%3BPirollo%2C+K%3BBlattner%2C+W%3BChang%2C+E+H&rft.aulast=Srivastava&rft.aufirst=S&rft.date=1990-12-01&rft.volume=348&rft.issue=6303&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-28 N1 - Date created - 1991-01-28 N1 - Date revised - 2017-01-13 N1 - Gene symbol - p53 N1 - SuppNotes - Comment In: Nature. 1990 Dec 20-27;348(6303):681-2 [2259380] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Acute renal tubular necrosis and death of mice orally infected with Escherichia coli strains that produce Shiga-like toxin type II. AN - 80160683; 2254023 AB - Escherichia coli O157:H7 strains have been implicated as etiologic agents in food-borne outbreaks of hemorrhagic colitis and the hemolytic-uremic syndrome. A prototype E. coli O157:H7 strain, designated 933, produces Shiga-like toxin I (SLT-I) and SLT-II and harbors a 60-MDa plasmid. In a previous study, streptomycin-treated mice were fed 933 together with a derivative cured of the 60-MDa plasmid (designated 933cu). Strain 933cu colonized poorly, but in approximately one-third of the animals, an isolate of 933cu was obtained from the feces that had regained the ability to colonize well. This isolate, designated 933cu-rev, killed all of the animals when fed alone to mice. In this investigation, two types of experiments were done to assess whether SLT-I, SLT-II, or both contributed to the death of mice fed 933cu-rev. (i) Mice were pretreated with monoclonal antibodies to SLT-I, SLT-II, SLT-I and SLT-II, or cholera toxin (as a control) before infection with 933cu-rev. (ii) Mice were fed either an E. coli K-12 strain carrying cloned SLT-I genes or the same K-12 strain carrying cloned SLT-II genes. The results of both types of experiments indicated that the deaths of the orally infected mice were due solely to SLT-II. Extensive histological and selected electron microscopic examinations of various tissues from the infected animals suggested that death was due to acute renal cortical tubular necrosis consistent with toxic renal damage. These data indicate a critical role for SLT-II, but not SLT-I, in renal damage associated with E. coli O157:H7 infection of streptomycin-treated mice. JF - Infection and immunity AU - Wadolkowski, E A AU - Sung, L M AU - Burris, J A AU - Samuel, J E AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1990/12// PY - 1990 DA - December 1990 SP - 3959 EP - 3965 VL - 58 IS - 12 SN - 0019-9567, 0019-9567 KW - Antibodies, Monoclonal KW - 0 KW - Bacterial Toxins KW - Glycolipids KW - Shiga Toxin 2 KW - Iron KW - E1UOL152H7 KW - Streptomycin KW - Y45QSO73OB KW - Index Medicus KW - Animals KW - Kidney -- pathology KW - Iron -- physiology KW - Streptomycin -- pharmacology KW - Mice KW - Escherichia coli Infections -- pathology KW - Kidney -- ultrastructure KW - Glycolipids -- metabolism KW - Escherichia coli Infections -- complications KW - Antibodies, Monoclonal -- immunology KW - Bacterial Toxins -- genetics KW - Escherichia coli -- metabolism KW - Bacterial Toxins -- metabolism KW - Escherichia coli -- pathogenicity KW - Bacterial Toxins -- toxicity KW - Kidney Tubular Necrosis, Acute -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80160683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Acute+renal+tubular+necrosis+and+death+of+mice+orally+infected+with+Escherichia+coli+strains+that+produce+Shiga-like+toxin+type+II.&rft.au=Wadolkowski%2C+E+A%3BSung%2C+L+M%3BBurris%2C+J+A%3BSamuel%2C+J+E%3BO%27Brien%2C+A+D&rft.aulast=Wadolkowski&rft.aufirst=E&rft.date=1990-12-01&rft.volume=58&rft.issue=12&rft.spage=3959&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-22 N1 - Date created - 1991-01-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1987 Nov;55(11):2675-80 [2822579] Infect Immun. 1990 Aug;58(8):2438-45 [2196227] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] Biochem Biophys Res Commun. 1988 Apr 29;152(2):674-9 [3284526] Infect Immun. 1988 Aug;56(8):1926-33 [3294179] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] Hum Pathol. 1988 Sep;19(9):1102-8 [3047052] J Clin Microbiol. 1988 Oct;26(10):2127-31 [3053764] J Pediatr. 1988 Dec;113(6):1008-14 [3057156] J Biol Chem. 1989 Jan 5;264(1):596-601 [2642481] Nephron. 1989;51(2):207-10 [2644572] J Infect Dis. 1989 Apr;159(4):774-7 [2647865] Arch Biochem Biophys. 1989 Apr;270(1):391-7 [2648997] Biochem Biophys Res Commun. 1989 Apr 14;160(1):126-32 [2653314] Infect Immun. 1989 Dec;57(12):3743-50 [2807546] J Infect Dis. 1989 Dec;160(6):994-8 [2685131] Infect Immun. 1990 Mar;58(3):611-8 [2155181] Proc Natl Acad Sci U S A. 1977 Apr;74(4):1417-20 [323852] Infect Immun. 1980 Oct;30(1):170-9 [7002787] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] Anal Biochem. 1980 Dec;109(2):399-402 [7224165] Recomb DNA Tech Bull. 1982 Mar;5(1):1-5 [7041199] Gene. 1982 Jan;17(1):79-89 [6281139] Methods Enzymol. 1982;83:139-91 [7047999] N Engl J Med. 1983 Mar 24;308(12):681-5 [6338386] Lancet. 1983 Mar 26;1(8326 Pt 1):702 [6132054] Lancet. 1983 Sep 3;2(8349):573 [6136724] J Clin Microbiol. 1983 Sep;18(3):512-20 [6355145] Infect Immun. 1983 Dec;42(3):914-23 [6196297] Science. 1984 Nov 9;226(4675):694-6 [6387911] J Exp Med. 1984 Dec 1;160(6):1767-81 [6392471] Mol Gen Genet. 1984;197(2):337-41 [6097798] J Infect Dis. 1985 May;151(5):775-82 [3886804] Infect Immun. 1985 Dec;50(3):695-700 [3905611] Infect Immun. 1986 Jan;51(1):16-23 [3510166] J Exp Med. 1986 Jun 1;163(6):1391-404 [3519828] Infect Immun. 1986 Jul;53(1):135-40 [3522426] J Infect Dis. 1986 Aug;154(2):338-41 [3522760] Infect Immun. 1987 Feb;55(2):455-61 [2879796] J Biol Chem. 1987 Feb 5;262(4):1779-85 [3543013] J Biol Chem. 1987 Jun 25;262(18):8834-9 [3298243] Infect Immun. 1988 Jan;56(1):106-11 [3121508] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - cAMP-independent effects of cholera toxin on B cell activation. I. A possible role for cell surface ganglioside GM1 in B cell activation. AN - 80089659; 2172379 AB - Cholera toxin has been used as a tool to study the effects of cAMP on the activation of B cells but may have effects independent of its ability to elevate cAMP. We found five lines of evidence which suggested that cholera toxin suppressed mitogen-stimulated B cell activation through a cAMP-independent pathway. 1) Cholera toxin (1 microgram/ml) was consistently more suppressive than forskolin (100 microM) despite the induction of higher intracellular cAMP levels by forskolin. 2) Cholera toxin was more suppressive at 1 microgram/ml than at 0.1 microgram/ml despite equivalent elevations of cAMP. 3) Washing B cells following their incubation with cholera toxin reversed much of the inhibition without altering intracellular cAMP levels. 4) The A subunit of cholera toxin, which at high concentrations (10 micrograms/ml) induced levels of cAMP comparable to those induced by cholera toxin (1 and 0.1 microgram/ml), did not inhibit B cell activation. 5) cAMP derivatives at high concentrations were much less effective than was cholera toxin in suppressing B cell activation. Although the elevation of cAMP may cause a mild inhibition of B cell proliferation, we found that even a marked elevation of cAMP did not suppress B cell proliferation, unless the elevation was persistent. We did, however, observe that the degree of toxin inhibition more closely paralleled binding of the toxin to B cells than toxin stimulation of cAMP. This result raised the possibility that binding of cholera toxin to its ganglioside GM1 receptor mediated an inhibitory signal which suppressed B cell proliferation. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Francis, M L AU - Moss, J AU - Fitz, T A AU - Mond, J J AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1990/11/15/ PY - 1990 DA - 1990 Nov 15 SP - 3162 EP - 3169 VL - 145 IS - 10 SN - 0022-1767, 0022-1767 KW - Colforsin KW - 1F7A44V6OU KW - 8-Bromo Cyclic Adenosine Monophosphate KW - 23583-48-4 KW - G(M1) Ganglioside KW - 37758-47-7 KW - Bucladesine KW - 63X7MBT2LQ KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Colforsin -- pharmacology KW - Mice KW - Bucladesine -- pharmacology KW - 8-Bromo Cyclic Adenosine Monophosphate -- pharmacology KW - Female KW - Mice, Inbred DBA KW - Lymphocyte Activation -- drug effects KW - B-Lymphocytes -- drug effects KW - G(M1) Ganglioside -- physiology KW - Cholera Toxin -- pharmacology KW - Cyclic AMP -- analysis KW - B-Lymphocytes -- immunology KW - Cyclic AMP -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80089659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=cAMP-independent+effects+of+cholera+toxin+on+B+cell+activation.+I.+A+possible+role+for+cell+surface+ganglioside+GM1+in+B+cell+activation.&rft.au=Francis%2C+M+L%3BMoss%2C+J%3BFitz%2C+T+A%3BMond%2C+J+J&rft.aulast=Francis&rft.aufirst=M&rft.date=1990-11-15&rft.volume=145&rft.issue=10&rft.spage=3162&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-12 N1 - Date created - 1990-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolism of 2S-hydroxy-3-methylcholanthrene by rat liver microsomes. AN - 80072906; 2225338 AB - Products formed in the metabolism of 2S-hydroxy-3-methylcholanthrene (2S-OH-3MC) by liver microsomes prepared from phenobarbital-treated rats were isolated by sequential use of reversed-phase and normal-phase HPLC. Metabolites of 2S-OH-3MC were characterized by UV-visible absorption, mass and circular dichroic spectra, and chiral stationary phase HPLC analyses. The metabolites that had been identified were 2S-hydroxy-3-hydroxymethylcholanthrene (2S-OH-3-OHMC), 3MC-2-one, 3MC-2-one 9,10-dihydrodiol, 8-hydroxy-2S-OH-3MC, a pair of stereoisomers 3MC (trans)-1R,2R-diol and (cis)-1S,2R-diol in a ratio of approximately 11:89, a pair of diastereomers 2S-OH-3MC 9R,10R-dihydrodiol and 2S-OH-3MC 9S,10S-dihydrodiol in a ratio of approximately 9:1, and a pair of diastereomers 2S-OH-3MC 11R,12R-dihydrodiol and 2S-OH-3MC 11S,12S-dihydrodiol in a ratio of approximately 77:23. A few tentatively identified minor metabolites were 3-OHMC trans-1R,2R-diol, 10-hydroxy-2S-OH-3MC, a 9,10-dihydrodiol derived from 3MC cis-1S,2R-diol, and a 11,12-dihydrodiol and two diastereomeric 9,10-dihydrodiols derived from 2S-OH-3-OHMC. Since the racemic 2-OH-3MC is a known potent carcinogen and 2S-OH-3MC is the most abundant metabolite of 3MC, some of the 2S-OH-3MC metabolites identified in this study may be further converted to proximate and ultimate carcinogens which may contribute to the overall carcinogenicity exhibited by 3MC. JF - Carcinogenesis AU - Shou, M G AU - Yang, S K AD - Department of Pharmacology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889-4799. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 2037 EP - 2045 VL - 11 IS - 11 SN - 0143-3334, 0143-3334 KW - Methylcholanthrene KW - 56-49-5 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Phenobarbital -- pharmacology KW - Spectrophotometry, Ultraviolet KW - Mice KW - Male KW - Chromatography, High Pressure Liquid KW - Hydroxylation KW - Microsomes, Liver -- metabolism KW - Methylcholanthrene -- metabolism KW - Methylcholanthrene -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80072906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Metabolism+of+2S-hydroxy-3-methylcholanthrene+by+rat+liver+microsomes.&rft.au=Shou%2C+M+G%3BYang%2C+S+K&rft.aulast=Shou&rft.aufirst=M&rft.date=1990-11-01&rft.volume=11&rft.issue=11&rft.spage=2037&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-27 N1 - Date created - 1990-12-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Coordinate regulation of siderophore and diphtheria toxin production by iron in Corynebacterium diphtheriae. AN - 80348624; 2151460 AB - Iron is an environmental signal which regulates the coordinate expression of genes associated with virulence in many pathogenic bacteria. In response to iron-deprivation, lysogenic Corynebacterium diphtheriae C7 (beta) synthesizes and secretes diphtheria toxin and siderophore and induces a high-affinity iron uptake system. Diphtheria toxin is encoded by beta phage, but genes for siderophore production are encoded on the bacterial chromosome. Diphtheria toxin and siderophore production were shown to be coordinately induced during late logarithmic phase growth of wild-type C7(beta) in iron-limited medium. C. diphtheriae mutant C7hm723 produced siderophore and toxin constitutively under low-iron and high-iron conditions, but in mutants HC1, HC3, HC4, and HC5 their synthesis was partially repressed under high-iron conditions. The phenotypes of HC1, HC3, HC4, and HC5 are consistent with their severe defects in iron uptake, but the phenotype of C7hm723 is more likely to be explained by inactivation of the repressor for the iron regulon of C. diphtheriae. JF - Microbial pathogenesis AU - Tai, S P AU - Krafft, A E AU - Nootheti, P AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 267 EP - 273 VL - 9 IS - 4 SN - 0882-4010, 0882-4010 KW - Cetrimonium Compounds KW - 0 KW - Diphtheria Toxin KW - Hydroxybenzoates KW - Iron Chelating Agents KW - Piperazines KW - Repressor Proteins KW - Siderophores KW - chrome azurol S KW - 1667-99-8 KW - EDDA KW - 5657-17-0 KW - Edetic Acid KW - 9G34HU7RV0 KW - Iron KW - E1UOL152H7 KW - cetrimonium KW - Z7FF1XKL7A KW - Index Medicus KW - Virulence KW - Promoter Regions, Genetic KW - Edetic Acid -- pharmacology KW - Iron -- pharmacology KW - Diphtheria Toxin -- biosynthesis KW - Repressor Proteins -- drug effects KW - Iron Chelating Agents -- metabolism KW - Hydroxybenzoates -- analysis KW - Gene Expression Regulation, Bacterial -- drug effects KW - Corynebacterium diphtheriae -- genetics KW - Corynebacterium diphtheriae -- pathogenicity KW - Diphtheria Toxin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80348624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+pathogenesis&rft.atitle=Coordinate+regulation+of+siderophore+and+diphtheria+toxin+production+by+iron+in+Corynebacterium+diphtheriae.&rft.au=Tai%2C+S+P%3BKrafft%2C+A+E%3BNootheti%2C+P%3BHolmes%2C+R+K&rft.aulast=Tai&rft.aufirst=S&rft.date=1990-10-01&rft.volume=9&rft.issue=4&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Microbial+pathogenesis&rft.issn=08824010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-25 N1 - Date created - 1991-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oral contraceptives and breast cancer. AN - 80065010; 2220962 AB - Among women in general the risk of breast cancer through 59 years of age does not appear to be affected appreciably by the use of oral contraceptives. Nonetheless, concern continues to be expressed about the effects of early age at first use, long-term duration of use, formulation, and a variety of other factors thought to influence breast cancer risk in the presence of oral contraception. A number of recent studies restricted to young women suggest that long-term use may increase the risk of disease occurring very early, but the present lack of consistent findings in well-conducted epidemiologic studies prevents any certain conclusion with regard to cause-and-effect. However, if an increased risk were indeed present, the most plausible interpretation is that long-term oral contraception promotes earlier clinical manifestation of breast cancer in some women while having no net impact on their lifetime risk of the disease. JF - American journal of obstetrics and gynecology AU - Schlesselman, J J AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1990/10// PY - 1990 DA - October 1990 SP - 1379 EP - 1387 VL - 163 IS - 4 Pt 2 SN - 0002-9378, 0002-9378 KW - Contraceptives, Oral KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Population KW - Age Factors KW - Population Dynamics KW - Contraceptive Methods--side effects KW - Breast Cancer KW - Research Report KW - Oral Contraceptives--side effects KW - Longterm Effects KW - Cancer KW - Neoplasms KW - Population Characteristics KW - Contraception KW - Risk Factors KW - Demographic Factors KW - Diseases KW - Literature Review KW - Family Planning KW - Time Factors KW - Biology KW - Humans KW - Adult KW - Female KW - Contraceptives, Oral -- adverse effects KW - Contraceptives, Oral -- administration & dosage KW - Breast Neoplasms -- epidemiology KW - Breast Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80065010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Oral+contraceptives+and+breast+cancer.&rft.au=Schlesselman%2C+J+J&rft.aulast=Schlesselman&rft.aufirst=J&rft.date=1990-10-01&rft.volume=163&rft.issue=4+Pt+2&rft.spage=1379&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=00029378&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-11-19 N1 - Date created - 1990-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Note on the Attenuation of Surface Gravity Waves by Rainfall AN - 19115867; 9104298 AB - Rainfall has long been associated with damping of short surface gravity waves. A theory is presented which uses a thin rain-induced turbulent surface layer to explain the enhanced attenuation. In the presence of a thin turbulent surface layer, the e-folding attenuation time for the 30 cm wavelength surface gravity waves needed for remote sensing of the ocean surface using synthetic aperture radar (SAR) is reduced from several minutes to several seconds. This explains the observation of low SAR radar return from regions of high rainfall. Longer wavelengths are also affected depending on the strength of the mixing and the thickness of the turbulent layer. (Author 's abstract) JF - Journal of Geophysical Research (C) Oceans JGRCEY, Vol. 95, No. 10, p 18,353-18,355, October 15, 1990. 1 fig, 13 ref. AU - Nystuen, JA AD - Naval Postgraduate School Y1 - 1990/10// PY - 1990 DA - Oct 1990 KW - Water Resources Abstracts KW - Gravity waves Ocean waves Radar Rainfall Surface water Water KW - surface profiles Attenuation Mathematical models Remote sensing KW - Turbulent flow Wavelengths KW - SW 5080:Evaluation, processing and publication KW - SW 0815:Precipitation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19115867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Note+on+the+Attenuation+of+Surface+Gravity+Waves+by+Rainfall&rft.au=Nystuen%2C+JA&rft.aulast=Nystuen&rft.aufirst=JA&rft.date=1990-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Snow/Cloud Discrimination with Multispectral Satellite Measurements AN - 19107413; 9105853 AB - One of the most significant problems that has plagued automated cloud classification systems is discrimination between low clouds and snow cover; in the visible and infrared regions of the electromagnetic spectrum that are used most often in satellite analysis, low clouds and snow cover have similar radiometric properties. An algorithm has been developed and evaluated for discriminating between clouds, snow-covered land, and snow-free land in satellite image data. The multispectral technique uses daytime images of NOAA AVHRR channels 1 (0.63 micrometers), 3 (3.7 micrometers), and 4 (11.0 micrometers). Reflectance was derived for channel 3 by using the channel 4 emission temperature to estimate and remove the channel 3 thermal emission. Separation of clouds from snow and land was based primarily on the derived channel 3 reflectance. Observed reflectance in channel 3 was 0.02 to 0.04 for snow, 0.03 to 0.10 for land, 0.02 to 0.27 for ice clouds and 0.08 to 0.36 for liquid clouds. These ranges overlap for thin cirrus and snow, so the routine attempts analysis of cirrus based on differences in transmission between channels 3 and 4. Six cases were analyzed and the total cloud cover was verified against a total of 110 surface observations in the standard categories of clear, scattered, broken, and overcast. One of the cases was examined in detail using the algorithm procedures and results. Analysis of cloud cover from the satellite algorithm matched surface observations at 55% of the stations, and was one category different at 33% of the stations. The algorithm differed from the surface observations by two categories at 9% of the stations and by three categories at 4% of the stations. A major remaining problem is discrimination between ice clouds and snow cover. (Author 's abstract) JF - Journal of Applied Meteorology JAMOAX, Vol. 29, No. 10, p 994-1004, October 1990. 9 fig, 5 tab, 17 ref. AU - Wash, CH AU - Durkee, P A AU - Allen, R C AD - Naval Postgraduate School Y1 - 1990/10// PY - 1990 DA - Oct 1990 KW - Water Resources Abstracts KW - Algorithms Cloud cover Data interpretation Meteorological data KW - collection Remote sensing Satellite technology Snow cover Clouds KW - Infrared imagery Landsat images Radiometry Reflectance Ice KW - SW 5040:Data acquisition KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19107413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Snow%2FCloud+Discrimination+with+Multispectral+Satellite+Measurements&rft.au=Wash%2C+CH%3BDurkee%2C+P+A%3BAllen%2C+R+C&rft.aulast=Wash&rft.aufirst=CH&rft.date=1990-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Oxidation of sulfhydryl groups and inhibition of the (Ca2+ + Mg2+)-ATPase by arsenazo III. AN - 79987470; 2144457 AB - In the presence of divalent cations, the metallochromic Ca2+ indicator arsenazo III is reduced by sulfhydryl groups to form an azo anion radical. Reduced arsenazo III is reoxidized back to its original state by oxygen. The formation of the arsenazo III azo anion radical in the presence of sarcoplasmic reticulum vesicles leads to the rapid inhibition of the (Ca2+ + Mg2+)-ATPase. These data indicate that several factors should be considered when arsenazo III is used as a Ca2+ indicator; (1) Functionally important sulfhydryl groups may be oxidized by arsenazo III; (2) the generation of free radicals by arsenazo III reduction may be toxic to the system being studied; (3) the absorbance spectrum of arsenazo III is altered when reduced by sulfhydryl groups. JF - Biochimica et biophysica acta AU - Beeler, T AD - Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1990/09/07/ PY - 1990 DA - 1990 Sep 07 SP - 264 EP - 267 VL - 1027 IS - 3 SN - 0006-3002, 0006-3002 KW - Azo Compounds KW - 0 KW - Free Radicals KW - Sulfhydryl Compounds KW - Arsenazo III KW - 1668-00-4 KW - Ca(2+) Mg(2+)-ATPase KW - EC 3.6.1.- KW - Calcium-Transporting ATPases KW - EC 3.6.3.8 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Oxidation-Reduction KW - Animals KW - Kinetics KW - Enzyme Activation -- drug effects KW - Sulfhydryl Compounds -- metabolism KW - Sarcoplasmic Reticulum -- drug effects KW - Sarcoplasmic Reticulum -- enzymology KW - Ca(2+) Mg(2+)-ATPase -- antagonists & inhibitors KW - Azo Compounds -- pharmacology KW - Calcium-Transporting ATPases -- antagonists & inhibitors KW - Arsenazo III -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79987470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Oxidation+of+sulfhydryl+groups+and+inhibition+of+the+%28Ca2%2B+%2B+Mg2%2B%29-ATPase+by+arsenazo+III.&rft.au=Beeler%2C+T&rft.aulast=Beeler&rft.aufirst=T&rft.date=1990-09-07&rft.volume=1027&rft.issue=3&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-16 N1 - Date created - 1990-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Integrated autonomic and behavioral responses to L/N Ca2(+)-channel blocker omega-conotoxin in conscious rats. AN - 79988544; 1697739 AB - omega-Conotoxin (omega-ctx) was used as a probe for studying the putative role of brain L/N-type Ca2+ channels in regulation of autonomic functions. Rats were injected intracerebroventricularly (icv) with omega-ctx, and hemodynamic, biochemical and behavioral variables were monitored. omega-Ctx (0.032-10 nmol/kg) caused a persistent, dose-dependent shaking behavior, complex thermoregulatory changes, and motor deficits lasting up to 48 h. Cardiovascular responses to omega-ctx included tachycardia (+71 +/- 16%, P less than 0.01) and elevated arterial blood pressure (+16 +/- 1%, P less than 0.05) associated with increased circulating levels of norepinephrine and epinephrine. Higher doses, 1 or 10 nmol/kg, resulted in circulatory shock and death. Central administration of 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester (TMB-8), diltiazem (100 or 1,000 nmol/kg), neomycin (100 nmol/kg, each), nifedipine (10 nmol/kg), and CdCl2 (100 nmol/kg), which represent intracellular, non-specific N-, L-, and L/N-type Ca2(+)-channel blockers, respectively, did not cause any behavioral or hemodynamic effects, whereas the L-channel agonist BAY K 8644 (100 nmol/kg icv) caused a mild transient pressor response. Pretreatment with the gamma-aminobutyric acid (GABA) agonist muscimol (icv) or a combined intravenous pretreatment with propranolol and N-methylatropine blocked the omega-ctx effects. Our data suggest that omega-ctx actions in the brain involve central GABAergic mechanisms modulated by yet a different type of Ca2+ channels not characterized by any of the known voltage-operated Ca2+ channels. JF - The American journal of physiology AU - Shapira, S AU - Adeyemo, O M AU - Feuerstein, G AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - R427 EP - R438 VL - 259 IS - 3 Pt 2 SN - 0002-9513, 0002-9513 KW - Calcium Channel Blockers KW - 0 KW - Catecholamines KW - Peptides, Cyclic KW - omega-Conotoxins KW - Conus magus toxin KW - 107407-86-3 KW - 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester KW - 71145-03-4 KW - Diltiazem KW - EE92BBP03H KW - Index Medicus KW - Hemodynamics -- drug effects KW - Animals KW - Blood Chemical Analysis KW - Body Temperature -- drug effects KW - Nervous System -- drug effects KW - 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester -- pharmacology KW - Injections, Intraventricular KW - Rats, Inbred Strains KW - Rats KW - Catecholamines -- blood KW - Diltiazem -- pharmacology KW - Motor Activity -- drug effects KW - Male KW - Behavior, Animal -- drug effects KW - Calcium Channel Blockers -- pharmacology KW - Autonomic Nervous System -- drug effects KW - Peptides, Cyclic -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79988544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Integrated+autonomic+and+behavioral+responses+to+L%2FN+Ca2%28%2B%29-channel+blocker+omega-conotoxin+in+conscious+rats.&rft.au=Shapira%2C+S%3BAdeyemo%2C+O+M%3BFeuerstein%2C+G&rft.aulast=Shapira&rft.aufirst=S&rft.date=1990-09-01&rft.volume=259&rft.issue=3+Pt+2&rft.spage=R427&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-11 N1 - Date created - 1990-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Increased cytotoxicity of ricin in a putative Golgi-defective mutant of Chinese hamster ovary cell. AN - 79945885; 2117543 AB - We have studied the cytotoxicity of ricin in a monensin-resistant mutant (MonR-31) of Chinese hamster ovary (CHO) cell line which is presumably altered in Golgi functions/structures. The cytotoxicity of ricin was increased in MonR-31 mutant cells compared with that in its parental CHO cells. In wild-type CHO cells, the cytotoxicity of ricin was enhanced by HN4Cl, bafilomycin A1, or nigericin. The enhancement of ricin cytotoxicity by these compounds was greatly reduced in MonR-31 mutant cells. Brefeldin A (BFA), which disrupts the structure of the Golgi apparatus, inhibits the cytotoxicity of ricin in both CHO and MonR-31 cells. We have also examined the effects of glycosylation inhibitors and the removal of high mannose oligosaccharide chains in ricin on the ricin hypersensitivity in MonR-31 cells. The hypersensitivity of MonR-31 cells to ricin is apparently not due to any difference in glycosylation between CHO and MonR-31 cells or in the processing of oligosaccharides on ricin by the target cells. Nigericin at low concentration (10 nM), which has no effect on the cytotoxicity of diphtheria toxin, enhances the ricin cytotoxicity, but inhibits the modeccin cytotoxicity. Our results suggest that important step(s) in the intoxication process of CHO cells by ricin and modeccin take place in the Golgi region. JF - Experimental cell research AU - Yoshida, T AU - Chen, C H AU - Zhang, M S AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 11 EP - 16 VL - 190 IS - 1 SN - 0014-4827, 0014-4827 KW - Alkaloids KW - 0 KW - Anti-Bacterial Agents KW - Cyclopentanes KW - Diphtheria Toxin KW - Lectins KW - Macrolides KW - Plant Lectins KW - Ribosome Inactivating Proteins, Type 2 KW - Toxins, Biological KW - Ammonium Chloride KW - 01Q9PC255D KW - Brefeldin A KW - 20350-15-6 KW - modeccin KW - 65988-88-7 KW - bafilomycin A1 KW - 88899-55-2 KW - Ricin KW - 9009-86-3 KW - Nigericin KW - RRU6GY95IS KW - Swainsonine KW - RSY4RK37KQ KW - Index Medicus KW - Animals KW - Anti-Bacterial Agents -- pharmacology KW - Glycosylation KW - Ammonium Chloride -- pharmacology KW - Lectins -- pharmacology KW - Nigericin -- pharmacology KW - Cyclopentanes -- pharmacology KW - Toxins, Biological -- pharmacology KW - Diphtheria Toxin -- pharmacology KW - Alkaloids -- pharmacology KW - Mutation KW - Cell Line KW - Protein Biosynthesis -- drug effects KW - Golgi Apparatus -- physiology KW - Ricin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79945885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Increased+cytotoxicity+of+ricin+in+a+putative+Golgi-defective+mutant+of+Chinese+hamster+ovary+cell.&rft.au=Yoshida%2C+T%3BChen%2C+C+H%3BZhang%2C+M+S%3BWu%2C+H+C&rft.aulast=Yoshida&rft.aufirst=T&rft.date=1990-09-01&rft.volume=190&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-21 N1 - Date created - 1990-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Psychometric Theory and the Problem of Relating Prior and Subsequent Absences AN - 61248210; 91X6385 AB - Absence researchers have interpreted the correlation between two consecutive periods of absence as both a coefficient of stability & as an instance of predictive validation. Using parallel test theory as its psychometric framework, the measure equivalence assumption underlying the stability interpretation of pairs of absence measures is evaluated. Analysis of data from five published absence studies indicates that contiguous periods of absenteeism rarely meet the measure equivalence assumptions of stability analysis. 1 Table, 20 References. AA JF - Journal of Organizational Behavior AU - Steel, Robert P AD - AFIT/LSR Wright-Patterson Air Force Base, OH 45433-6583 Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 407 EP - 411 VL - 11 IS - 5 SN - 0894-3796, 0894-3796 KW - prior-subsequent absence correlation, measure equivalence assumption evaluated KW - secondary data KW - Measurement KW - Psychological Factors KW - Psychometric Analysis KW - Absenteeism KW - article KW - 0621: complex organization; jobs, work organization, workplaces, & unions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61248210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Organizational+Behavior&rft.atitle=Psychometric+Theory+and+the+Problem+of+Relating+Prior+and+Subsequent+Absences&rft.au=Steel%2C+Robert+P&rft.aulast=Steel&rft.aufirst=Robert&rft.date=1990-09-01&rft.volume=11&rft.issue=5&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Journal+of+Organizational+Behavior&rft.issn=08943796&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JORBEJ N1 - SubjectsTermNotLitGenreText - Absenteeism; Psychological Factors; Measurement; Psychometric Analysis ER - TY - JOUR T1 - Biological responses to liposome-encapsulated hemoglobin (LEH) are improved by a PAF antagonist. AN - 79983529; 2397568 AB - Liposome-encapsulated hemoglobin (LEH) is an experimental oxygen-carrying blood substitute. Previous studies in our laboratory with hydrogenated soy lecithin-based LEH indicated that while this solution maintained some physicochemical and oxygen-carrying properties of red blood cells, it evoked several transient (30-120 min) untoward biological responses, such as hypertension, tachycardia, thrombocytopenia, hemoconcentration, and elevation of plasma thromboxane B2 (TXB2). Such biochemical, hematological, and hemodynamic derangements are also produced by platelet-activating factor (PAF). The purpose of this study was to test the biological responses to administration of a newly produced synthetic distearoyl phosphatidylcholine-based LEH (s-DSPC-LEH) in the normal conscious rat (n = 6-11) and to examine the role of PAF in these processes. Systemic (IV) administration of S-DSPC-LEH caused transient hypotension (-23 +/- 8 mmHg, P less than 0.05), bradycardia (-24 +/- 11 bpm, P less than 0.05) followed by tachycardia (+62 +/- 21 bpm, P less than 0.05), decreased cardiac index (217 +/- 21 ml/min/kg, P less than 0.01), increased peripheral resistance (0.570 +/- 0.003 mmHg/ml/min/kg, P less than 0.01), transient leukocytosis (+6,870 +/- 1,801/microliters, P less than 0.05), hemoconcentration (+5.2 +/- 0.4%, P less than 0.01), thrombocytopenia (-160 +/- 18 X 10(3)/microliters, P less than 0.01), and increase in plasma TXB2 (45.0 +/- 1.9 pg/100 microliters, P less than 0.01). Separate infusion of the liposome vehicle or free hemoglobin, the two components of s-DSPC-LEH, did not evoke any consistent responses. Administration of the PAF antagonist BN 50739 (10 mg/kg, i.p.) 30 min prior to LEH prevented the hemodynamic changes and hemoconcentration induced by s-DSPC-LEH. These data suggest that hemoglobin/phospholipid interactions might account for the transient side effects of s-DSPC-LEH, possibly through interactions with blood elements and the resultant production of PAF and TXA2. Furthermore, PAF antagonists incorporated into or co-administered with LEH might enhance its biological applications. JF - Circulatory shock AU - Rabinovici, R AU - Rudolph, A S AU - Yue, T L AU - Feuerstein, G AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 431 EP - 445 VL - 31 IS - 4 SN - 0092-6213, 0092-6213 KW - Azepines KW - 0 KW - Blood Substitutes KW - Hemoglobins KW - Liposomes KW - Phosphatidylcholines KW - Platelet Activating Factor KW - Triazoles KW - 1,2-distearoyllecithin KW - 043IPI2M0K KW - BN 50739 KW - 128672-07-1 KW - Thromboxane B2 KW - 54397-85-2 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Hemodynamics -- drug effects KW - Animals KW - Drug Interactions KW - Chemistry, Physical KW - Platelet Count -- drug effects KW - Thromboxane B2 -- blood KW - Rats KW - Rats, Inbred Strains KW - Leukocyte Count -- drug effects KW - Oxygen -- blood KW - Chemical Phenomena KW - Male KW - Platelet Activating Factor -- antagonists & inhibitors KW - Azepines -- adverse effects KW - Blood Substitutes -- pharmacology KW - Hemoglobins -- administration & dosage KW - Triazoles -- pharmacology KW - Hemoglobins -- pharmacology KW - Triazoles -- adverse effects KW - Blood Substitutes -- adverse effects KW - Azepines -- pharmacology KW - Hemoglobins -- therapeutic use KW - Azepines -- administration & dosage KW - Liposomes -- adverse effects KW - Triazoles -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79983529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulatory+shock&rft.atitle=Biological+responses+to+liposome-encapsulated+hemoglobin+%28LEH%29+are+improved+by+a+PAF+antagonist.&rft.au=Rabinovici%2C+R%3BRudolph%2C+A+S%3BYue%2C+T+L%3BFeuerstein%2C+G&rft.aulast=Rabinovici&rft.aufirst=R&rft.date=1990-08-01&rft.volume=31&rft.issue=4&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Circulatory+shock&rft.issn=00926213&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-18 N1 - Date created - 1990-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Adverse drug effects attributed to phenylpropanolamine: a review of 142 case reports. AN - 79925489; 2200264 AB - Phenylpropanolamine (PPA) is contained in about 106 products, over half of which are available over-the-counter (OTC). Most are cough/cold remedies; nine are OTC diet aids. More than nine million Americans were using OTC diet aids in 1981, making PPA the fifth most used drug in the United States, responsible for over $200 million in revenues. The safety of PPA remains controversial. Although most controlled studies indicate minimal pressor effects with recommended doses, adverse drug reactions (ADRs) continue to be documented. Since 1965, 142 ADRs have been reported in 85 studies, 69% of these in North America. Many such cases may go unrecognized. About two thirds of all ADRs occurred in females and in patients under 30. Of ADRs attributed to legitimately sold PPA products, 85% occurred after consumption of OTC products versus only 15% after prescription drugs. The PPA product often contained combination ingredients, or PPA was consumed along with additional drugs. An overdose of PPA was taken in about a third of the cases. After ingestion of non-overdose amounts, 82% of the ADRs were severe. The most frequent side effects involved symptoms compatible with acute hypertension, with severe headache the most common complaint. Twenty-four intracranial hemorrhages, eight seizures, and eight deaths (most due to stroke) were associated with PPA ingestion. We have summarized these data in an effort to alert clinicians to the prevalence of usage of PPA products and the potential for adverse effects. In patients who present with elevated blood pressure or signs of acute hypertension, especially hypertensive encephalopathy of undetermined origin, we recommend inquiry about recent ingestion of PPA-containing diet aids and cough/cold products and suggest having such patients remain upright rather than supine. JF - The American journal of medicine AU - Lake, C R AU - Gallant, S AU - Masson, E AU - Miller, P AD - Department of Psychiatry, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 195 EP - 208 VL - 89 IS - 2 SN - 0002-9343, 0002-9343 KW - Drug Combinations KW - 0 KW - Phenylpropanolamine KW - 33RU150WUN KW - Abridged Index Medicus KW - Index Medicus KW - Stereoisomerism KW - Drug Interactions KW - Humans KW - Phenylpropanolamine -- adverse effects KW - Phenylpropanolamine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79925489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Adverse+drug+effects+attributed+to+phenylpropanolamine%3A+a+review+of+142+case+reports.&rft.au=Lake%2C+C+R%3BGallant%2C+S%3BMasson%2C+E%3BMiller%2C+P&rft.aulast=Lake&rft.aufirst=C&rft.date=1990-08-01&rft.volume=89&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-12 N1 - Date created - 1990-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Differential cytokine induction by doses of lipopolysaccharide and monophosphoryl lipid A that result in equivalent early endotoxin tolerance. AN - 79878946; 1695201 AB - The phenomenon of early endotoxin tolerance, which is induced by sublethal injection of lipopolysaccharide (LPS), results in a protracted period of hyporesponsiveness that is most profound at 3 to 4 days after injection and is marked by reduced cytokine production after a challenge injection of LPS. Early endotoxin tolerance is also induced by the nontoxic LPS derivative monophosphoryl lipid A (MPL), although much more of the monophosphoryl derivative is required to produce a state of tolerance equivalent to that evoked by LPS. In this study, equivalent tolerance-inducing doses of LPS and MPL were tested, and the levels of cytokines induced by LPS and MPL were compared. Although induced levels of colony-stimulating factor were comparable following doses of LPS and MPL that elicited an equivalent state of early endotoxin tolerance, levels of tumor necrosis factor, interleukin-6, and interferon were significantly lower in MPL-injected animals. These results suggest that the lowered toxicity of MPL may be related to its elicitation of significantly lower levels of potentially toxic intermediaries such as tumor necrosis factor, interferon, and interleukin-6. JF - Infection and immunity AU - Henricson, B E AU - Benjamin, W R AU - Vogel, S N AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 2429 EP - 2437 VL - 58 IS - 8 SN - 0019-9567, 0019-9567 KW - Biological Factors KW - 0 KW - Blood Glucose KW - Colony-Stimulating Factors KW - Cytokines KW - Endotoxins KW - Interleukin-6 KW - Lipid A KW - Lipopolysaccharides KW - Tumor Necrosis Factor-alpha KW - Interferons KW - 9008-11-1 KW - monophosphoryl lipid A KW - MWC0ET1L2P KW - Index Medicus KW - Interferons -- biosynthesis KW - Animals KW - Blood Glucose -- metabolism KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Colony-Stimulating Factors -- biosynthesis KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Mice KW - Interleukin-6 -- biosynthesis KW - Female KW - Biological Factors -- biosynthesis KW - Lipopolysaccharides -- administration & dosage KW - Lipid A -- administration & dosage KW - Lipopolysaccharides -- pharmacology KW - Immune Tolerance -- immunology KW - Endotoxins -- immunology KW - Lipid A -- pharmacology KW - Lipid A -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79878946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Differential+cytokine+induction+by+doses+of+lipopolysaccharide+and+monophosphoryl+lipid+A+that+result+in+equivalent+early+endotoxin+tolerance.&rft.au=Henricson%2C+B+E%3BBenjamin%2C+W+R%3BVogel%2C+S+N&rft.aulast=Henricson&rft.aufirst=B&rft.date=1990-08-01&rft.volume=58&rft.issue=8&rft.spage=2429&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-21 N1 - Date created - 1990-08-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1988 Oct;56(10):2650-7 [3262089] Trans Assoc Am Physicians. 1968;81:334-44 [5721410] Infect Immun. 1986 Apr;52(1):6-11 [3514464] J Immunol. 1987 Apr 1;138(7):2143-8 [3494061] J Exp Med. 1986 Jun 1;163(6):1433-50 [3486936] Infect Immun. 1986 Sep;53(3):707-10 [3488965] Infect Immun. 1987 Jul;55(7):1622-5 [3596805] Prog Clin Biol Res. 1987;231:25-53 [3588622] J Immunol. 1985 Dec;135(6):3763-71 [3905964] Science. 1985 Aug 30;229(4716):869-71 [3895437] Science. 1985 Apr 12;228(4696):149-54 [3856324] J Virol. 1981 Feb;37(2):755-8 [6163873] J Clin Invest. 1942 Sep;21(5):589-99 [16694949] J Exp Med. 1965 Jun 1;121:911-33 [14319407] Eur J Immunol. 1987 Oct;17(10):1411-6 [3500054] J Immunol. 1986 Aug 1;137(3):858-62 [3487590] J Immunol. 1986 Nov 15;137(10):3189-94 [3021848] J Immunol. 1985 Jun;134(6):3868-75 [2985700] Proc Natl Acad Sci U S A. 1986 Dec;83(24):9679-83 [2948184] J Immunol. 1988 Dec 15;141(12):4196-202 [3143760] Prog Clin Biol Res. 1988;272:17-45 [3293075] J Immunol. 1986 Apr 15;136(8):2883-91 [2420874] Infect Immun. 1984 Aug;45(2):350-5 [6378795] Infect Immun. 1983 Jul;41(1):1-5 [6602767] Proc Natl Acad Sci U S A. 1983 Aug;80(15):4624-8 [6348772] J Biol Response Mod. 1984;3(1):1-9 [6707694] Scand J Infect Dis Suppl. 1982;31:8-21 [7048515] J Neurochem. 1981 Sep;37(3):702-8 [7276950] CRC Crit Rev Toxicol. 1977 Nov;5(3):239-318 [411630] N Engl J Med. 1978 Mar 16;298(11):607-12 [342955] J Reticuloendothel Soc. 1976 Mar;19(3):187-97 [1083433] Infect Immun. 1973 Oct;8(4):534-9 [4200540] Infect Immun. 1972 Nov;6(5):766-72 [4629205] Immunology. 1971 Sep;21(3):427-36 [4936184] Biochemistry. 1967 Aug;6(8):2363-72 [4867999] N Engl J Med. 1987 Feb 12;316(7):379-85 [3543677] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mouse model for colonization and disease caused by enterohemorrhagic Escherichia coli O157:H7. AN - 79875391; 2196227 AB - Enterohemorrhagic Escherichia coli O157:H7 isolates produce Shiga-like toxins and carry a 60-megadalton plasmid which encodes an adhesin for Henle 407 intestinal cells. A streptomycin-treated mouse model was used to compare the intestinal colonizing capacity of E. coli O157:H7 strain 933 with that of its 60-megadalton plasmid-cured derivative, strain 933cu. When fed individually to mice, both 933 and 933cu maintained a stable number of organisms per gram of feces, and the greatest numbers of 933 or 933cu were isolated from cecal and proximal colonic epithelial cells. When 933 and 933cu were simultaneously fed to mice, 933cu was unable to maintain a stable level of colonization in about two-thirds of the mice tested. However, in one-third of the mice, the number of 933cu in feces began to increase rapidly until a stable level of co-colonization with 933 was attained. The isolate from these mice, 933cu-rev, was excreted in high numbers when fed alone to mice and was found on epithelial cells throughout the entire large bowel and distal small intestine. Moreover, 933cu-rev grew in mucus from all segments of the intestine and at higher levels than strain 933 or 933cu. Only mice fed strain 933cu-rev died. Histopathological studies confirmed that mice fed 933cu-rev died from bilateral renal cortical tubular necrosis consistent with toxic insult, perhaps due to Shiga-like toxins. The virulence of 933cu-rev may reflect its ability to grow well in mucus and colonize the small as well as large bowel. JF - Infection and immunity AU - Wadolkowski, E A AU - Burris, J A AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1990/08// PY - 1990 DA - August 1990 SP - 2438 EP - 2445 VL - 58 IS - 8 SN - 0019-9567, 0019-9567 KW - Bacterial Outer Membrane Proteins KW - 0 KW - Streptomycin KW - Y45QSO73OB KW - Index Medicus KW - Animals KW - Kidney Tubular Necrosis, Acute -- pathology KW - Disease Models, Animal KW - Intestine, Large -- microbiology KW - Mice KW - Streptomycin -- administration & dosage KW - Intestine, Small -- microbiology KW - Mucus -- microbiology KW - Virulence -- genetics KW - Bacterial Outer Membrane Proteins -- genetics KW - Bacterial Outer Membrane Proteins -- administration & dosage KW - Species Specificity KW - Male KW - Escherichia coli Infections -- microbiology KW - Escherichia coli -- isolation & purification KW - Escherichia coli -- pathogenicity KW - Escherichia coli Infections -- mortality KW - Escherichia coli -- genetics KW - Escherichia coli Infections -- pathology KW - Plasmids KW - Escherichia coli -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79875391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Mouse+model+for+colonization+and+disease+caused+by+enterohemorrhagic+Escherichia+coli+O157%3AH7.&rft.au=Wadolkowski%2C+E+A%3BBurris%2C+J+A%3BO%27Brien%2C+A+D&rft.aulast=Wadolkowski&rft.aufirst=E&rft.date=1990-08-01&rft.volume=58&rft.issue=8&rft.spage=2438&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-21 N1 - Date created - 1990-08-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1970 Aug 15;227(5259):680-5 [5432063] Biochem Biophys Res Commun. 1988 Apr 29;152(2):674-9 [3284526] J Bacteriol. 1977 Aug;131(2):598-607 [328488] Infect Immun. 1978 Nov;22(2):462-72 [365759] Infect Immun. 1981 May;32(2):484-9 [6114035] Eur J Clin Microbiol. 1982 Jun;1(3):186-92 [6756909] N Engl J Med. 1983 Mar 24;308(12):681-5 [6338386] Lancet. 1983 Mar 26;1(8326 Pt 1):702 [6132054] Lancet. 1983 Sep 3;2(8349):573 [6136724] J Gen Microbiol. 1983 May;129(5):1549-58 [6352858] J Clin Microbiol. 1983 Sep;18(3):512-20 [6355145] Infect Immun. 1988 Sep;56(9):2373-8 [3044997] Hum Pathol. 1988 Sep;19(9):1102-8 [3047052] Infect Immun. 1989 Apr;57(4):1142-50 [2647633] J Clin Microbiol. 1990 Feb;28(2):293-5 [1968907] J Biol Chem. 1951 Nov;193(1):265-75 [14907713] Science. 1984 Nov 9;226(4675):694-6 [6387911] Infect Immun. 1985 Apr;48(1):139-45 [3920146] J Infect Dis. 1985 May;151(5):775-82 [3886804] Infect Immun. 1986 Jan;51(1):16-23 [3510166] Infect Immun. 1986 Mar;51(3):953-6 [3512443] J Infect Dis. 1986 Oct;154(4):712-6 [3528323] Infect Immun. 1987 Feb;55(2):455-61 [2879796] J Biol Chem. 1987 Jun 25;262(18):8834-9 [3298243] J Infect Dis. 1987 Jul;156(1):175-82 [3298451] Infect Immun. 1987 Aug;55(8):1824-9 [2886431] Infect Immun. 1987 Dec;55(12):3117-25 [3316033] Infect Immun. 1988 May;56(5):1030-5 [3281898] J Biol Chem. 1973 Apr 10;248(7):2536-41 [4698230] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Phenylpropanolamine and caffeine use among diet center clients. AN - 80079370; 2228392 AB - We surveyed phenylpropanolamine (PPA) use and overuse among 309 diet center clients. Fifty-one percent of all subjects surveyed reported using PPA drugs: 44 percent used cold medicines and 16 percent used diet aids. Twenty-two percent of diet aid users and 7 percent of cold medicine users reported that they deliberately used more than the dosage recommended to improve efficacy. Among diet aid users, 59 percent also regularly consumed caffeine. Despite package warnings, individuals who had been told by their doctors that they were hypertensive used PPA products as often as normotensive individuals. PPA, the fifth most frequently used drug in the USA, is contained in over-the-counter (OTC) diet aids as well as OTC and prescription cold medicines. Severe adverse drug reactions (ADRs) including hypertensive crisis, stroke and death have been attributed to PPA products. Clinical studies have shown that using greater than recommended doses of PPA and using PPA in combination with caffeine may increase the risk of ADRs. Overweight patients may be particularly at risk for ADRs to PPA because they are likely to be hypertensive and to use diet aids. We recommend informing diet center clients of the potential dangers of consuming PPA products, especially more than the recommended dose, in the presence of hypertension, and when other sympathomimetic drugs are being taken. JF - International journal of obesity AU - Lake, C R AU - Rosenberg, D AU - Quirk, R AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, MD 20814-4799. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 575 EP - 582 VL - 14 IS - 7 KW - Sympathomimetics KW - 0 KW - Phenylpropanolamine KW - 33RU150WUN KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Sympathomimetics -- adverse effects KW - Hypertension -- chemically induced KW - Substance-Related Disorders KW - Hypertension -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80079370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+obesity&rft.atitle=Phenylpropanolamine+and+caffeine+use+among+diet+center+clients.&rft.au=Lake%2C+C+R%3BRosenberg%2C+D%3BQuirk%2C+R&rft.aulast=Lake&rft.aufirst=C&rft.date=1990-07-01&rft.volume=14&rft.issue=7&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=International+journal+of+obesity&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-11 N1 - Date created - 1990-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cholinergic manipulation alters stimulus-evoked metabolic activity in cat somatosensory cortex. AN - 79901493; 2376628 AB - The role of acetylcholine (ACh) in cerebral cortical activity has recently been reevaluated. It now seems clear that this neurotransmitter increases the magnitude of cortical responses. Although substantial information has been gathered regarding the role of ACh in sensory information processing, little is known about the participation of ACh in the organization of maps in the cerebral cortex. To address this issue, we used 2 methods to manipulate the supply of ACh in the somatosensory cortex of cats: 1) unilateral neurotoxic lesions of the basal forebrain and 2) unilateral topical applications of the cholinergic antagonist, atropine. For each experimental condition, the animal received an injection of 2-deoxyglucose (2DG) while identical somatic stimuli were delivered to the right and left forepaws. In the somatosensory cortex, the 2DG uptake most often occurred in the form of patches that extended from layer II to IV. When the patches were reconstructed into 2-dimensional maps of activity throughout the somatosensory cortex, they formed strips that ran in the rostrocaudal direction. The reconstructed maps revealed that the 2DG patterns in ACh-depleted and the normal cortex were similar in their overall topographic distribution. Depletion or antagonism of ACh, however, caused the stimulus-evoked metabolic label to be reduced in dimension and density. Measurements of background activity levels were obtained by using 1) cytochrome oxidase histochemistry or 2) metabolic activity values in regions of somatosensory cortex that were not specifically stimulated. This analysis indicated that background values in the ACh-depleted hemispheres were not different from those in the normal hemispheres. The absence of ACh therefore appears to reduce the cortical response to stimulation, while background activity values do not change. These observations indicate that ACh plays a significant role in the processing of sensory information and the organization of somatosensory cortical maps. JF - The Journal of comparative neurology AU - Juliano, S L AU - Ma, W AU - Bear, M F AU - Eslin, D AD - Department of Anatomy, USUHS, Bethesda, Maryland 20814. Y1 - 1990/07/01/ PY - 1990 DA - 1990 Jul 01 SP - 106 EP - 120 VL - 297 IS - 1 SN - 0021-9967, 0021-9967 KW - Atropine KW - 7C0697DR9I KW - Deoxyglucose KW - 9G2MP84A8W KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Stimulation, Chemical KW - Osmolar Concentration KW - Acetylcholine -- physiology KW - Animals KW - Cats KW - Neuronal Plasticity KW - Autoradiography KW - Atropine -- pharmacology KW - Male KW - Female KW - Parasympathetic Nervous System -- physiology KW - Somatosensory Cortex -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79901493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+comparative+neurology&rft.atitle=Cholinergic+manipulation+alters+stimulus-evoked+metabolic+activity+in+cat+somatosensory+cortex.&rft.au=Juliano%2C+S+L%3BMa%2C+W%3BBear%2C+M+F%3BEslin%2C+D&rft.aulast=Juliano&rft.aufirst=S&rft.date=1990-07-01&rft.volume=297&rft.issue=1&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+comparative+neurology&rft.issn=00219967&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-06 N1 - Date created - 1990-09-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Metabolism of the potent carcinogen 3-methylcholanthrylene by rat liver microsomes. AN - 79884874; 2372877 AB - The products formed in the metabolism of 3-methylcholanthrylene (3MCE), either in the presence or in the absence of an epoxide hydrolase inhibitor, 3,3,3-trichloropropylene 1,2-oxide (TCPO), with an NADPH-regenerating system and liver microsomes from 3-methylcholanthrene (3MC)-treated male Sprague-Dawley rats were separated by reversed-phase and normal-phase HPLC. The metabolites were characterized by UV-visible absorption spectral analysis, and by comparing their retention times on reversed-phase and normal-phase HPLC with authentic 3MC derivatives whenever available. In addition to 3MC trans-1,2-diol, 3MC-1-one, and 3MC-2-one reported earlier by other investigators, 3-hydroxymethylcholanthrylene (3-OHMCE), 3-OHMCE trans-11,12-dihydrodiol, 3MCE trans-11,12-dihydrodiol, 3MCE trans-9, 10-dihydrodiol. 9- and 10-hydroxy-3MCE. 3MC-2-one trans-9,10-dihydrodiol, and a chemically unstable 3MCE 1,2-epoxide were identified as metabolites of 3MCE. 3MC cis-1,2-diol, a previously reported metabolite of 3MCE, was not detectable. In the presence of TCPO, metabolites that have been identified include 3-OHMCE, 3-OHMCE 11,12-epoxide. 3MCE 11,12-epoxide, 3MC-2-one, 3MC-1-one, 9-hydroxy-3MCE, 10-hydroxy-3MCE, and an unstable metabolic intermediate 3MCE 1,2-epoxide. The results suggest that 3MCE 1,2-epoxide, 3MCE 9,10-diol-7,8-epoxide, and 3MC-2-one 9,10-diol-7,8-epoxide may be involved in the metabolic activation of 3MCE to carcinogenic form. JF - Carcinogenesis AU - Yang, S K AU - Prasanna, P AU - Weems, H B AU - Jacobs, M M AU - Fu, P P AD - Department of Pharmacology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 1195 EP - 1201 VL - 11 IS - 7 SN - 0143-3334, 0143-3334 KW - NADP KW - 53-59-8 KW - Methylcholanthrene KW - 56-49-5 KW - Index Medicus KW - Rats KW - Animals KW - Chemistry KW - Spectrum Analysis KW - Chemical Phenomena KW - NADP -- metabolism KW - Chromatography, High Pressure Liquid KW - Microsomes, Liver -- metabolism KW - Methylcholanthrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79884874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Metabolism+of+the+potent+carcinogen+3-methylcholanthrylene+by+rat+liver+microsomes.&rft.au=Yang%2C+S+K%3BPrasanna%2C+P%3BWeems%2C+H+B%3BJacobs%2C+M+M%3BFu%2C+P+P&rft.aulast=Yang&rft.aufirst=S&rft.date=1990-07-01&rft.volume=11&rft.issue=7&rft.spage=1195&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-29 N1 - Date created - 1990-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - An Economic Assessment of the UAE's Development Strategy: The Effectiveness of Government Expenditure in Stimulating Industrial Development AN - 61665238; 199201415 AB - The direction of industrial development in the United Arab Emirates (UAE) since the early 1970s is examined. After outlining the UAE's economic structure -- which is based directly or indirectly on oil & gas -- a factor analysis of the major economic structural characteristics of the Arab countries & the UAE's sectoral change over the period following the initial oil price increases is presented to illuminate how the UAE economy has evolved. Results reveal that the UAE's industry has not been successful in stimulating diversification away from the oil sector, primarily because of government industrial policy & high rates of investment in industry before preconditions for successful industrialization were established. 11 Tables. Adapted from the source document. JF - Journal of Developing Societies AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 182 EP - 202 VL - 6 IS - 2 SN - 0169-796X, 0169-796X KW - industrial development, post-1970 United Arab Emirates KW - government expenditure KW - United Arab Emirates KW - Industrial Development KW - Government Spending KW - Development Strategies KW - Economic Structure KW - article KW - 7250: social planning/policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61665238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Developing+Societies&rft.atitle=An+Economic+Assessment+of+the+UAE%27s+Development+Strategy%3A+The+Effectiveness+of+Government+Expenditure+in+Stimulating+Industrial+Development&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1990-07-01&rft.volume=6&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Journal+of+Developing+Societies&rft.issn=0169796X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Industrial Development; United Arab Emirates; Development Strategies; Government Spending; Economic Structure ER - TY - JOUR T1 - The Policy Relevance of Recent Research on the Economics of Third World Military Expenditures AN - 61637303; 199101454 AB - An overview of quantitative research on Third World defense expenditures & their relationship to economic growth. Contradictory findings on the effects of defense spending from research conducted in the 1970s & 1980s were of little use to Third World policymakers. However, mounting evidence suggests that military expenditures can stabilize domestic economic performance. A consistent pattern emerging from quantitative research shows that about 20 Third World states -- in general, those that produce arms, are more economically successful, & have access to foreign exchange -- derive positive effects from military spending. The remaining 40 countries do not derive positive economic impacts from defense expenditures. 3 Tables, 18 References. C. Grindle JF - Journal of Social, Political and Economic Studies AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1990/07// PY - 1990 DA - July 1990 SP - 213 EP - 223 VL - 15 IS - 2 SN - 0193-5941, 0193-5941 KW - defense expenditures-economic growth relationship, Third World countries KW - research review KW - Expenditures KW - Armaments KW - Economic Development KW - Developing Countries KW - National Security KW - article KW - 8309: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61637303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social%2C+Political+and+Economic+Studies&rft.atitle=The+Policy+Relevance+of+Recent+Research+on+the+Economics+of+Third+World+Military+Expenditures&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1990-07-01&rft.volume=15&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social%2C+Political+and+Economic+Studies&rft.issn=01935941&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Developing Countries; National Security; Economic Development; Armaments; Expenditures ER - TY - JOUR T1 - Fungal infections in the pediatric cancer patient. AN - 79824051; 2191445 AB - Chemotherapy, while undeniably effective in controlling or eradicating a variety of neoplasms, is also accompanied by a number of toxicities. Foremost among these is neutropenia, which places the pediatric cancer patient at risk for serious fungal infections. The fungal organisms most commonly responsible for infection in neutropenic children are Candida, Aspergillus, Mucor, and the Phycomycetes. Common sites of infection include the oral cavity, sinuses, lung, and bloodstream. Recently, candidal infection of the liver was recognized as a growing problem. Diagnosis of deep-seated fungal infections, such as pneumonia and hepatic candidiasis, is extremely difficult, often requiring open-lung or liver biopsy, which a patient's hematologic status may not permit. Because early treatment significantly improves prognosis, empirical antifungal therapy may be indicated in selected patients. Amphotericin B is currently the antifungal agent of choice against most fungal organisms. Antifungal efficacy studies based on animal models of disseminated candidal infection suggest that amphotericin B combined with 5-fluorocytosine (5-FC) is more effective than amphotericin B alone against most deep-seated Candida infections. The investigational drug, fluconazole, appears as effective as amphotericin B plus 5-FC in the prevention and early treatment of disseminated candidiasis, and clinical trials to assess this potentially important role for the new antifungal agent are now being initiated. JF - Seminars in oncology AU - Pizzo, P A AU - Walsh, T J AD - Infectious Disease Section, National Cancer Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20892. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 6 EP - 9 VL - 17 IS - 3 Suppl 6 SN - 0093-7754, 0093-7754 KW - Antifungal Agents KW - 0 KW - Index Medicus KW - Candidiasis -- drug therapy KW - Humans KW - Candidiasis -- pathology KW - Adult KW - Child, Preschool KW - Antifungal Agents -- therapeutic use KW - Neoplasms -- complications KW - Mycoses -- diagnosis KW - Mycoses -- drug therapy KW - Mycoses -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79824051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+oncology&rft.atitle=Fungal+infections+in+the+pediatric+cancer+patient.&rft.au=Pizzo%2C+P+A%3BWalsh%2C+T+J&rft.aulast=Pizzo&rft.aufirst=P&rft.date=1990-06-01&rft.volume=17&rft.issue=3+Suppl+6&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Seminars+in+oncology&rft.issn=00937754&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-19 N1 - Date created - 1990-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 1-Hydroxy- and 2-hydroxy-3-methylcholanthrene: regioselective and stereoselective formations in the metabolism of 3-methylcholanthrene and enantioselective disposition in rat liver microsomes. AN - 79801005; 2347067 AB - Absolute configurations of enantiomeric 1-hydroxy-3-methylcholanthrene (1-OH-3MC) and 2-hydroxy-3-methyl-cholanthrene (2-OH-3MC) were determined by the exciton chirality circular dichroism (CD) method as their p-nitrobenzoate derivatives. Enantiomers of 1-OH-3MC were resolved by HPLC using a column packed with chiral stationary phase (CSP) (R)-N-(3,5-dinitrobenzoyl)phenylglycine covalently bonded to gamma-aminopropylsilanized silica. Enantiomers of 2-OH-3MC were resolved as diastereomeric (-)-methoxyacetates by normal-phase HPLC. 1-OH-3MC and 2-OH-3MC, formed in the metabolism of 3MC by liver microsomes from untreated, phenobarbital (PB)-treated and 3MC-treated male Sprague-Dawley rats, were first isolated as a mixture by reversed-phase HPLC and subsequently separated by normal-phase HPLC. Concentration ratios of [1-OH-3MC]:[2-OH-3MC] formed in the metabolism of 3MC by three rat liver microsomal preparations (at 0.5 mg protein per ml of incubation mixture and an incubation time of 10 min) were found to be: 30:70 (control), 21:79 (PB treated) and 10:90 (3MC treated) respectively. R/S enantiomer ratios of 1-OH-3MC formed in the metabolism of 3MC by three rat liver microsomal preparations were determined by CSP HPLC: 35:65 (control), 39:61 (PB treated) and 46:54 (3MC treated) respectively. R/S enantiomer ratios of 2-OH-3MC formed in the metabolism of 3MC by three rat liver microsomal preparations were determined by CD spectral data: 14:86 (control), 6:94 (PB treated) and 6:94 (3MC treated) respectively. Metabolism of racemic 1-OH-3MC and 2-OH-3MC by all three rat liver microsomal preparations was found to be substrate enantioselective; the rate of 1S-OH-3MC metabolism was faster than that of 1R-OH-3MC, whereas the rate of 2R-OH-3MC metabolism was faster than that of 2S-OH-3MC. JF - Carcinogenesis AU - Shou, M AU - Yang, S K AD - Department of Pharmacology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 933 EP - 940 VL - 11 IS - 6 SN - 0143-3334, 0143-3334 KW - 2-hydroxy-3-methylcholanthrene KW - 3308-64-3 KW - 1-hydroxy-3-methylcholanthrene KW - 3342-98-1 KW - Methylcholanthrene KW - 56-49-5 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Phenobarbital -- pharmacology KW - Biotransformation KW - Isomerism KW - Circular Dichroism KW - Organ Specificity KW - Male KW - Chromatography, High Pressure Liquid KW - Methylcholanthrene -- pharmacology KW - Microsomes, Liver -- metabolism KW - Microsomes, Liver -- drug effects KW - Methylcholanthrene -- isolation & purification KW - Methylcholanthrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79801005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=1-Hydroxy-+and+2-hydroxy-3-methylcholanthrene%3A+regioselective+and+stereoselective+formations+in+the+metabolism+of+3-methylcholanthrene+and+enantioselective+disposition+in+rat+liver+microsomes.&rft.au=Shou%2C+M%3BYang%2C+S+K&rft.aulast=Shou&rft.aufirst=M&rft.date=1990-06-01&rft.volume=11&rft.issue=6&rft.spage=933&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-12 N1 - Date created - 1990-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Mutational analysis of the Shiga toxin and Shiga-like toxin II enzymatic subunits. AN - 79793323; 2345150 AB - The A-subunit polypeptides of Shiga toxin, the Shiga-like toxins (SLTs), and the plant lectin ricin inactivate eucaryotic ribosomes by enzymatically depurinating 28S rRNA. Comparison of the amino acid sequences of the members of the Shiga toxin family and ricin revealed two regions of significant homology that lie within a proposed active-site cleft of the ricin A chain. In previous studies, these conserved sequences of the SLT-I and ricin A subunits have been implicated as active sites. To establish the importance of these regions of homology, we used site-directed mutagenesis to alter the A-subunit sequences of two members of the Shiga toxin family. Substitution of an aspartic acid for glutamic acid 166 of the Slt-IIA subunit decreased the capacity of the polypeptides to inhibit protein synthesis at least 100-fold in a cell-free translation system. However, this mutation did not prevent the expression of immunoreactive, full-length Slt-IIA. In addition, SLT-II holotoxin containing the mutated A subunit was 1,000-fold less toxic to Vero cells. Finally, site-directed mutagenesis was used to delete sequences encoding amino acids 202 through 213 of the Shiga toxin A subunit. Although this deletion did not prevent holotoxin assembly, it abolished cytotoxic activity. JF - Journal of bacteriology AU - Jackson, M P AU - Deresiewicz, R L AU - Calderwood, S B AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 3346 EP - 3350 VL - 172 IS - 6 SN - 0021-9193, 0021-9193 KW - Bacterial Toxins KW - 0 KW - Enterotoxins KW - Shiga Toxin 2 KW - Shiga Toxins KW - Index Medicus KW - Amino Acid Sequence KW - Mutation KW - Binding Sites KW - Bacterial Toxins -- analysis KW - Enterotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79793323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Mutational+analysis+of+the+Shiga+toxin+and+Shiga-like+toxin+II+enzymatic+subunits.&rft.au=Jackson%2C+M+P%3BDeresiewicz%2C+R+L%3BCalderwood%2C+S+B&rft.aulast=Jackson&rft.aufirst=M&rft.date=1990-06-01&rft.volume=172&rft.issue=6&rft.spage=3346&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-03 N1 - Date created - 1990-07-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1985 Dec;50(3):695-700 [3905611] Microb Pathog. 1987 Feb;2(2):147-53 [3333796] J Infect Dis. 1986 Aug;154(2):338-41 [3522760] J Biol Chem. 1987 Apr 15;262(11):5398-403 [3558397] J Biol Chem. 1987 Apr 25;262(12):5908-12 [3571242] Science. 1987 Jun 5;236(4806):1252-8 [3296192] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] J Bacteriol. 1987 Sep;169(9):4313-9 [3040689] Mol Cell Biol. 1989 Feb;9(2):415-20 [2469000] EMBO J. 1989 Jan;8(1):301-8 [2714255] Microb Pathog. 1989 Feb;6(2):113-22 [2654533] Infect Immun. 1989 Dec;57(12):3743-50 [2807546] Mol Cell Biol. 1989 Nov;9(11):5012-21 [2689871] Cell. 1977 Mar;10(3):521-36 [403011] J Bacteriol. 1978 Jun;134(3):1141-56 [149110] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] J Biol Chem. 1981 Aug 25;256(16):8732-8 [7021550] Infect Immun. 1983 Jul;41(1):430-3 [6345399] Methods Enzymol. 1983;101:20-78 [6310323] DNA. 1984 Dec;3(6):479-88 [6096101] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2568-72 [3357883] Infect Immun. 1988 Aug;56(8):1926-33 [3294179] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] J Biol Chem. 1989 Jan 5;264(1):596-601 [2642481] Infect Immun. 1986 Jul;53(1):135-40 [3522426] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Demographic Change in the Arab Gulf States: Recent Trends and Implications for the Future AN - 61259587; 91Y1540 AB - Census & government survey data from major Persian Gulf states -- Saudi Arabia, Bahrain, Oman, Qatar, & Kuwait -- are used to investigate the political & economic implications of demographic change in the region. After briefly outlining the composition of the work force, it is suggested that the Gulf states are characterized by low participation by nationals & a substantial dependence on foreign workers. It is argued that the lack of clearly defined work force localization policies, the ability of employers to reduce labor costs by contracting non-nationals, decreased income in the private sector, & a civil service system that minimizes competition have hindered efforts to localize the work force. While Gulf governments have attempted increased "Arabization" of the Gulf labor market -- hiring non-national Arabs -- this policy has caused economic & political problems: conservative governments must contend with potentially radical Arab populations, & Arab migrants bring dependents, thus increasing social costs. Future Gulf trends include a decrease in the demand for unskilled & semiskilled workers & an increased need for professional & higher skilled workers for service & maintenance sectors. It is suggested that these trends will result in a high rate of retention of foreign labor, accompanied by a decline in immigrant work flows & heightened mobility of non-nationals within the individual Gulf states. 4 Tables. L. Baker JF - Scandinavian Journal of Development Alternatives AU - Looney, Robert E AD - National Security Affairs Naval Postgraduate School, Monterey CA 93943 Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 103 EP - 115 VL - 9 SN - 0280-2791, 0280-2791 KW - demographic change, Arab Gulf states, political/economic implications KW - census/government survey data KW - Qatar KW - Saudi Arabia KW - Foreign Workers KW - Bahrain KW - Demographic Change KW - Oman KW - Labor Force Participation KW - Labor Migration KW - Kuwait KW - article KW - 1837: demography and human biology; demography (population studies) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61259587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Development+Alternatives&rft.atitle=Demographic+Change+in+the+Arab+Gulf+States%3A+Recent+Trends+and+Implications+for+the+Future&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1990-06-01&rft.volume=9&rft.issue=&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Development+Alternatives&rft.issn=02802791&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SJDAEA N1 - SubjectsTermNotLitGenreText - Demographic Change; Labor Force Participation; Foreign Workers; Saudi Arabia; Oman; Kuwait; Qatar; Bahrain; Labor Migration ER - TY - JOUR T1 - In vitro tumor necrosis factor induction assay for analysis of febrile toxicity associated with amphotericin B preparations. AN - 79848749; 2360827 AB - Amphotericin B can stimulate macrophages to produce tumor necrosis factor alpha (TNF alpha), one of the inflammatory mediators that may be responsible for the febrile toxicity associated with drug administration. The purpose of this study was to compare the in vitro TNF-inducing activity of one recalled lot of an amphotericin B preparation which was associated with more frequent febrile reactions in patients with a preparation not associated with a greater incidence of febrile reaction. We found that the former preparation induced significantly more TNF than the latter preparation, and the in vitro data correlated with the results of rabbit pyrogen testing. The in vitro TNF induction assay may serve as a screening tool for the selection of the least pyrogenic lots of amphotericin B preparation. JF - Antimicrobial agents and chemotherapy AU - Chia, J K AU - McManus, E J AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20892. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 906 EP - 908 VL - 34 IS - 5 SN - 0066-4804, 0066-4804 KW - Tumor Necrosis Factor-alpha KW - 0 KW - amphotericin A KW - 6KQ75HL677 KW - Amphotericin B KW - 7XU7A7DROE KW - Index Medicus KW - Animals KW - Drug Contamination KW - Rabbits KW - Mice KW - Female KW - Fever -- chemically induced KW - Amphotericin B -- analogs & derivatives KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Amphotericin B -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79848749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=In+vitro+tumor+necrosis+factor+induction+assay+for+analysis+of+febrile+toxicity+associated+with+amphotericin+B+preparations.&rft.au=Chia%2C+J+K%3BMcManus%2C+E+J&rft.aulast=Chia&rft.aufirst=J&rft.date=1990-05-01&rft.volume=34&rft.issue=5&rft.spage=906&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-02 N1 - Date created - 1990-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 1986 Apr;29(4):584-8 [3707107] J Infect Dis. 1989 Jan;159(1):113-6 [2909629] Am Rev Respir Dis. 1963 Feb;87:264-8 [13995039] J Clin Microbiol. 1984 Sep;20(3):323-9 [6386853] Life Sci. 1984 Mar 26;34(13):1249-52 [6708728] J Pharm Sci. 1984 Jun;73(6):835-8 [6737275] J Immunol. 1980 Oct;125(4):1671-7 [6997383] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oral ciprofloxacin versus ceftriaxone for the treatment of urethritis from resistant Neisseria gonorrhoeae in Zambia. AN - 79848259; 2113796 AB - Neisseria gonorrhoeae strains resistant to treatment with penicillin, tetracycline, and/or spectinomycin are increasing in prevalence in many parts of the world. In Zambia, 52% of N. gonorrhoeae isolates produced beta-lactamase in 1986. Few oral regimens have proven effective for treatment of resistant N. gonorrhoeae. We conducted a prospective, double-blind, randomized clinical trial of 250 mg of ciprofloxacin given orally versus 250 mg of ceftriaxone given intramuscularly for treatment of uncomplicated gonococcal urethritis in adult males. Two hundred men were enrolled and treated. The two groups were comparable in age (27.5 years), prevalence of latent syphilis (14 and 10%), and human immunodeficiency virus infection (32 and 38%). Of 165 patients with cultures positive for N. gonorrhoeae who returned for follow-up, ciprofloxacin cured 83 of 83 (100%), including 26 with penicillinase-producing N. gonorrhoeae (PPNG) and 21 with N. gonorrhoeae with chromosomally mediated resistance to multiple antibiotics (CMRNG), and ceftriaxone cured 81 of 82 (98.7%), including 30 with PPNG and 19 with CMRNG. Both treatment regimens were well tolerated. Chlamydia trachomatis in urethral exudate was found by direct fluorescent-antibody microscopic examination or by culture in 10 (5%) participants. All N. gonorrhoeae isolates were inhibited by ceftriaxone at 0.06 micrograms/ml, except one which was inhibited at 0.125 micrograms/ml, while ciprofloxacin inhibited all isolates at 0.03 micrograms/ml. Ciprofloxacin is a safe and effective therapy for uncomplicated gonococcal urethritis, including that caused by PPNG and CMRNG in human immunodeficiency virus-infected men. JF - Antimicrobial agents and chemotherapy AU - Bryan, J P AU - Hira, S K AU - Brady, W AU - Luo, N AU - Mwale, C AU - Mpoko, G AU - Krieg, R AU - Siwiwaliondo, E AU - Reichart, C AU - Waters, C AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 819 EP - 822 VL - 34 IS - 5 SN - 0066-4804, 0066-4804 KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Ceftriaxone KW - 75J73V1629 KW - Index Medicus KW - Population KW - AIDS/HIV KW - Laboratory Examinations And Diagnoses KW - Research Methodology KW - Physiology KW - Eastern Africa KW - Urogenital Effects KW - Evaluation KW - Drugs--administraction and dosage KW - Double-blind Studies KW - Diseases KW - Infections KW - Chlamydia KW - Reproductive Tract Infections KW - Treatment--beneficial effects KW - Antibiotics--administraction and dosage KW - Studies KW - Prospective Studies KW - English Speaking Africa KW - Zambia KW - Urogenital System KW - Sexually Transmitted Diseases KW - Examinations And Diagnoses KW - Africa KW - Gonorrhea KW - Developing Countries KW - Africa South Of The Sahara KW - Biology KW - Randomized Controlled Trials as Topic KW - Double-Blind Method KW - Humans KW - Adult KW - Drug Resistance, Microbial KW - Middle Aged KW - Chlamydia trachomatis -- drug effects KW - Microbial Sensitivity Tests KW - Male KW - Neisseria gonorrhoeae -- drug effects KW - Urethritis -- microbiology KW - Ciprofloxacin -- therapeutic use KW - Ciprofloxacin -- adverse effects KW - Gonorrhea -- microbiology KW - Ceftriaxone -- adverse effects KW - Urethritis -- drug therapy KW - Gonorrhea -- drug therapy KW - Ceftriaxone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79848259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Oral+ciprofloxacin+versus+ceftriaxone+for+the+treatment+of+urethritis+from+resistant+Neisseria+gonorrhoeae+in+Zambia.&rft.au=Bryan%2C+J+P%3BHira%2C+S+K%3BBrady%2C+W%3BLuo%2C+N%3BMwale%2C+C%3BMpoko%2C+G%3BKrieg%2C+R%3BSiwiwaliondo%2C+E%3BReichart%2C+C%3BWaters%2C+C&rft.aulast=Bryan&rft.aufirst=J&rft.date=1990-05-01&rft.volume=34&rft.issue=5&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-02 N1 - Date created - 1990-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bull World Health Organ. 1984;62(1):89-94 [6232015] N Engl J Med. 1985 Sep 5;313(10):607-11 [3160949] Ann Intern Med. 1986 Apr;104(4):524-6 [3006569] Sex Transm Dis. 1986 Jul-Sep;13(3):169-71 [3764628] Antimicrob Agents Chemother. 1986 Aug;30(2):267-9 [3094439] J Infect Dis. 1987 Apr;155(4):819-22 [3102635] Genitourin Med. 1987 Jun;63(3):214 [3475249] J Infect Dis. 1987 Dec;156(6):1002-4 [2960748] Genitourin Med. 1988 Apr;64(2):134 [3384431] Antimicrob Agents Chemother. 1988 May;32(5):723-5 [3293526] Pathol Biol (Paris). 1988 May;36(5):482-7 [3043344] J Infect Dis. 1988 Oct;158(4):881-4 [3171231] Ann Intern Med. 1989 Jan 1;110(1):5-7 [2491746] Sex Transm Dis. 1988 Oct-Dec;15(4):186-91 [3147522] Sex Transm Dis. 1988 Oct-Dec;15(4):211-6 [3147525] Sex Transm Dis. 1988 Oct-Dec;15(4):225-33 [3147527] Sex Transm Dis. 1988 Oct-Dec;15(4):234-43 [3147528] Antimicrob Agents Chemother. 1989 Feb;33(2):167-70 [2719459] Antimicrob Agents Chemother. 1989 May;33(5):612-4 [2502065] Sex Transm Dis. 1989 Jul-Sep;16(3):148-51 [2510329] Antimicrob Agents Chemother. 1989 Oct;33(10):1655-61 [2686545] Antimicrob Agents Chemother. 1989 Oct;33(10):1662-7 [2686546] Antimicrob Agents Chemother. 1989 Oct;33(10):1721-3 [2511799] Lancet. 1990 Jan 20;335(8682):165 [1967452] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - 9,10-Dihydroxy-9,10-dihydro-3-methylcholanthrene-2-one: a principal metabolite of the potent carcinogen 3-methylcholanthrene-2-one by rat liver microsomes. AN - 79716759; 2323008 AB - A principal metabolite, formed in the metabolism of the potent carcinogen 3-methylcholanthrene-2-one (3MC-2-one) by liver microsomes from either untreated, or phenobarbital-treated or 3-methylcholanthrene (3MC)-treated rats, was isolated by reversed-phase HPLC. This metabolite has been identified as a 9,10-dihydrodiol with a (9R,10R):(9S,10S) enantiomer ratio of approximately 84:16 by all three rat liver microsomal preparations. The 9,10-dihydrodiol metabolite and its NaBH4 reduction products [a pair of diastereomeric 9,10-dihydroxy-9, 10-dihydro-2-OH-3MC (2-OH-3MC 9,10-dihydrodiols)] were characterized by UV-visible absorption, mass, and circular dichroic spectral, and chiral stationary phase HPLC analyses. Identification of 9,10-dihydroxy-9,10-dihydro-3MC-2-one (3MC-2-one 9,10-dihydrodiol) as the predominant metabolite of the potent carcinogen 3MC-2-one suggests that 3MC-2-one may be metabolically activated to a bay region 9,10-diol-7,8-epoxide, similar to the previously established metabolic activation pathways of 3MC and 1-hydroxy-3-methylcholanthrene (1-OH-3MC). JF - Carcinogenesis AU - Shou, M AU - Yang, S K AD - Department of Pharmacology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 689 EP - 695 VL - 11 IS - 4 SN - 0143-3334, 0143-3334 KW - 9,10-dihydroxy-9,10-dihydro-3-methylcholanthrene-2-one KW - 127861-40-9 KW - 3-methylcholanthrene-2-one KW - 3343-08-6 KW - Methylcholanthrene KW - 56-49-5 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Molecular Structure KW - Animals KW - Chemistry KW - Biotransformation KW - Chemical Phenomena KW - Spectrophotometry, Ultraviolet KW - Enzyme Induction KW - Male KW - Chromatography, High Pressure Liquid KW - Microsomes, Liver -- metabolism KW - Methylcholanthrene -- isolation & purification KW - Methylcholanthrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79716759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=9%2C10-Dihydroxy-9%2C10-dihydro-3-methylcholanthrene-2-one%3A+a+principal+metabolite+of+the+potent+carcinogen+3-methylcholanthrene-2-one+by+rat+liver+microsomes.&rft.au=Shou%2C+M%3BYang%2C+S+K&rft.aulast=Shou&rft.aufirst=M&rft.date=1990-04-01&rft.volume=11&rft.issue=4&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-21 N1 - Date created - 1990-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Paraquat toxicity is increased in Escherichia coli defective in the synthesis of polyamines. AN - 79700665; 2181453 AB - We have shown that toxicity of paraquat for Escherichia coli is increased over 10-fold in strains defective in the biosynthesis of spermidine compared to isogenic strains containing spermidine. The increased sensitivity of these spermidine-deficient mutants to paraquat is eliminated by growth in medium containing spermidine or by endogenous supplementation of spermidine by the use of a speE+D+ plasmid. No paraquat toxicity is seen in the absence of oxygen, even in amine-deficient strains, indicating that superoxide is the agent responsible for the increased toxicity. However, the specific mechanisms responsible for the increased paraquat toxicity in the spermidine-deficient mutants remain to be determined. The marked sensitivity to paraquat of E. coli deficient in spermidine is of particular interest, since such mutants have no other phenotypic properties that can be easily assayed. This increased sensitivity has been used as the basis of a convenient method for scoring for mutants in polyamine biosynthesis and for the detection of plasmids containing the biosynthetic genes. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Minton, K W AU - Tabor, H AU - Tabor, C W AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 2851 EP - 2855 VL - 87 IS - 7 SN - 0027-8424, 0027-8424 KW - Polyamines KW - 0 KW - Paraquat KW - PLG39H7695 KW - Spermidine KW - U87FK77H25 KW - Putrescine KW - V10TVZ52E4 KW - Index Medicus KW - Genotype KW - Kinetics KW - Spermidine -- pharmacology KW - Aerobiosis KW - Putrescine -- pharmacology KW - Time Factors KW - Mutation KW - Anaerobiosis KW - Paraquat -- pharmacology KW - Escherichia coli -- drug effects KW - Polyamines -- metabolism KW - Escherichia coli -- genetics KW - Escherichia coli -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79700665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Paraquat+toxicity+is+increased+in+Escherichia+coli+defective+in+the+synthesis+of+polyamines.&rft.au=Minton%2C+K+W%3BTabor%2C+H%3BTabor%2C+C+W&rft.aulast=Minton&rft.aufirst=K&rft.date=1990-04-01&rft.volume=87&rft.issue=7&rft.spage=2851&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-04 N1 - Date created - 1990-05-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1989 May 15;264(14):7761-4 [2542241] Science. 1988 Jun 3;240(4857):1302-9 [3287616] J Biol Chem. 1956 Jan;218(1):97-106 [13278318] Science. 1985 Mar 22;227(4693):1485-7 [3883489] J Biol Chem. 1975 Apr 10;250(7):2648-54 [1091640] J Biol Chem. 1978 May 25;253(10):3671-6 [348695] J Biol Chem. 1978 Nov 25;253(22):8143-8 [213429] J Biol Chem. 1979 Nov 10;254(21):10846-52 [227855] J Biol Chem. 1966 Aug 25;241(16):3714-23 [5330964] J Biol Chem. 1979 Dec 25;254(24):12419-26 [159306] Methods Enzymol. 1983;94:83-91 [6413821] Biochem Biophys Res Commun. 1984 Jul 31;122(2):550-5 [6466327] Annu Rev Biochem. 1984;53:749-90 [6206782] Microbiol Rev. 1985 Mar;49(1):81-99 [3157043] J Biol Chem. 1985 Sep 5;260(19):10478-81 [3897218] J Bacteriol. 1986 Mar;165(3):972-7 [3005244] J Bacteriol. 1986 Jul;167(1):346-9 [3522550] Proc Natl Acad Sci U S A. 1986 Aug;83(16):6040-4 [3526348] J Bacteriol. 1986 Nov;168(2):1026-9 [3536846] Chem Biol Interact. 1987 Feb;61(2):139-49 [3829140] Am J Physiol. 1987 Jun;252(6 Pt 1):C663-9 [3109250] J Biol Chem. 1987 Nov 25;262(33):16037-40 [3316212] J Biol Chem. 1988 Feb 5;263(4):1910-4 [2828357] Life Sci. 1989;45(1):63-9 [2501609] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Benign cystic mesothelioma in a male. AN - 85222252; pmid-2178402 AB - We present a case of a male with benign cystic mesothelioma of the peritoneum. The literature is reviewed for previous case reports of this rare lesion in males. Benign cystic mesotheliomas occur predominantly in females. Despite a marked tendency to recur, no malignant degeneration has ever been demonstrated, and only one mortality has ever been attributed directly to this lesion. The diagnosis of this entity is made by confirming the benign mesothelial nature of the cells lining the cysts with electron microscopy or immunohistochemical staining. No significant difference in the clinicopathologic presentation of cystic mesotheliomas in men and women is found. JF - The American Journal of Gastroenterology AU - Canty, M D AU - Williams, J AU - Volpe, R J AU - Yunan, E AD - Department of Internal Medicine, National Naval Medical Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland. PY - 1990 SP - 311 EP - 315 VL - 85 IS - 3 SN - 0002-9270, 0002-9270 KW - Human KW - Adult KW - Tomography, X-Ray Computed KW - Mesothelioma KW - Case Report KW - Peritoneal Neoplasms KW - Ultrasonography KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85222252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Benign+cystic+mesothelioma+in+a+male.&rft.au=Canty%2C+M+D%3BWilliams%2C+J%3BVolpe%2C+R+J%3BYunan%2C+E&rft.aulast=Canty&rft.aufirst=M&rft.date=1990-03-01&rft.volume=85&rft.issue=3&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Comparison of the glycolipid receptor specificities of Shiga-like toxin type II and Shiga-like toxin type II variants. AN - 79648619; 2155181 AB - The antigenically distinct Shiga-like toxins (SLTs) SLT-1 and SLT-II are cytotoxic for both Vero and HeLa cells and use Gal alpha 1-4Gal beta 1-4Glc beta 1-1Cer (Gb3) molecules as functional receptors. SLT-II-related variants SLT-IIvp and SLT-IIvh, produced by a porcine isolate and a human isolate, respectively, are cytotoxic for Vero but not HeLa cells. To investigate the basis for these differences in cytotoxic specificity among SLTs, the nature of the receptor for the SLT-II variants was examined. First, the patterns of binding of SLT-II and the SLT-II variants to Gb3 receptor analogs Gal alpha 1-4Gal-bovine serum albumin and Gal alpha 1-4Gal beta 1-4Glc-bovine serum albumin were compared. SLT-IIvp bound the trisaccharide neoglycoprotein preferentially, while SLT-IIvh bound both analogs equally but with less affinity than did SLT-II. Next, the glycolipids to which the SLT-II variants bound in Vero and HeLa cells were identified by thin-layer chromatography. SLT-IIvp bound to Gb3, GalNAc beta 1-3Gal alpha 1-4Gal beta 1-4Glc beta 1-1Cer (Gb4), and Gal beta 1-3GalNAc beta 1-3Gal alpha 1-4Gal beta 1-4Glc beta 1-1Cer (Gb5) in Vero cells but only Gb3 in HeLa cells. However, SLT-IIvh bound to Gal alpha 1-4Gal beta 1-1Cer (Gb2) and Gb3 in HeLa cells but only Gb3 in Vero cells. In addition, hybrid toxins (SLT-IIvp subunit A with SLT-II subunit B or SLT-II subunit A with SLT-IIvp subunit B) were used to show that the receptor specificities of the SLTs was B subunit specific. These differences in receptor specificities are important in vivo, as evidenced by a 400-fold difference in the 50% lethal doses of purified SLT-IIvp and SLT-II (200 versus 0.5 ng, respectively) for mice. These data indicate that SLT-II-cytotoxic variants can occur as a consequence of differences in receptor specificity and affinity. JF - Infection and immunity AU - Samuel, J E AU - Perera, L P AU - Ward, S AU - O'Brien, A D AU - Ginsburg, V AU - Krivan, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 611 EP - 618 VL - 58 IS - 3 SN - 0019-9567, 0019-9567 KW - Bacterial Toxins KW - 0 KW - Enterotoxins KW - Glycoconjugates KW - Glycolipids KW - Receptors, Cell Surface KW - Receptors, Peptide KW - Shiga Toxin 1 KW - Shiga Toxin 2 KW - Guanylate Cyclase KW - EC 4.6.1.2 KW - Receptors, Guanylate Cyclase-Coupled KW - enterotoxin receptor KW - Index Medicus KW - Glycoconjugates -- metabolism KW - Animals KW - HeLa Cells KW - Lethal Dose 50 KW - Enzyme-Linked Immunosorbent Assay KW - Vero Cells KW - Mice KW - Mice, Inbred BALB C KW - Female KW - Receptors, Cell Surface -- metabolism KW - Bacterial Toxins -- metabolism KW - Enterotoxins -- metabolism KW - Glycolipids -- analysis KW - Escherichia coli -- pathogenicity KW - Receptors, Cell Surface -- analysis KW - Bacterial Toxins -- toxicity KW - Glycolipids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79648619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Comparison+of+the+glycolipid+receptor+specificities+of+Shiga-like+toxin+type+II+and+Shiga-like+toxin+type+II+variants.&rft.au=Samuel%2C+J+E%3BPerera%2C+L+P%3BWard%2C+S%3BO%27Brien%2C+A+D%3BGinsburg%2C+V%3BKrivan%2C+H+C&rft.aulast=Samuel&rft.aufirst=J&rft.date=1990-03-01&rft.volume=58&rft.issue=3&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-30 N1 - Date created - 1990-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1986 Jul;53(1):135-40 [3522426] Infect Immun. 1989 Dec;57(12):3743-50 [2807546] J Biol Chem. 1987 Feb 5;262(4):1779-85 [3543013] J Biol Chem. 1987 Jun 25;262(18):8834-9 [3298243] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] Infect Immun. 1987 Nov;55(11):2675-80 [2822579] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Methods Enzymol. 1974;32:345-67 [4374628] Am J Vet Res. 1976 Jan;37(1):15-24 [1108715] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] Anal Biochem. 1980 Dec;109(2):399-402 [7224165] J Recept Res. 1980;1(2):199-213 [6895387] Methods Enzymol. 1982;83:139-91 [7047999] J Infect Dis. 1982 Dec;146(6):763-9 [6754826] Infect Immun. 1983 May;40(2):675-83 [6341244] J Exp Med. 1984 Dec 1;160(6):1767-81 [6392471] J Infect Dis. 1985 May;151(5):775-82 [3886804] Biochem Biophys Res Commun. 1985 Jul 31;130(2):879-84 [3839673] J Exp Med. 1986 Jun 1;163(6):1391-404 [3519828] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] Biochem Biophys Res Commun. 1988 Apr 29;152(2):674-9 [3284526] Proc Natl Acad Sci U S A. 1988 Jun;85(12):4441-5 [2837767] Infect Immun. 1988 Aug;56(8):1926-33 [3294179] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] Infect Immun. 1989 Apr;57(4):1339-42 [2647636] Arch Biochem Biophys. 1989 Apr;270(1):391-7 [2648997] J Infect Dis. 1989 May;159(5):881-9 [2651533] Microb Pathog. 1989 Feb;6(2):113-22 [2654533] J Biol Chem. 1989 Jul 25;264(21):12520-5 [2663859] Microb Pathog. 1989 May;6(5):381-90 [2671581] Infect Immun. 1986 Aug;53(2):372-7 [3755421] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavior and Prevention of AIDS. Bases of Research and Intervention AN - 746086548; 13127787 AB - At present, modification of specific, typically social behaviors to reduce or eliminate risk of AIDS is the only way to control spread of the disease. Social psychological research that has implications for the prevention of AIDS and HIV infection, including research concerning group and normative pressures, attitude formation and change, and social context, is reviewed Some ongoing AIDS intervention efforts are also discussed. By applying social psychological findings to AIDS education and prevention efforts, we may learn more about the dynamics associated with being at risk for HIV infection and perhaps further our knowledge of social pressures in general. Until a vaccine or cure is developed for this diseased our knowledge of social behavior will play a large role in both changing the public's attitudes toward AIDS and its victims and modifying or eliminating risk behaviors that lead to HIV infection and spread JF - Personality and Social Psychology Bulletin AU - O'Keeffe, Mary K AU - Nesselhof-Kendall, Sarah AU - Baum, Andrew AD - Uniformed Services University of the Health Sciences Y1 - 1990/03// PY - 1990 DA - Mar 1990 SP - 166 EP - 180 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 16 IS - 1 SN - 0146-1672, 0146-1672 KW - Risk Abstracts KW - vaccines KW - Acquired immune deficiency syndrome KW - Psychology KW - personality KW - attitudes KW - intervention KW - prevention KW - infection KW - social behavior KW - Education KW - Behavior KW - Human immunodeficiency virus KW - Reviews KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746086548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Social+Psychology+Bulletin&rft.atitle=Behavior+and+Prevention+of+AIDS.+Bases+of+Research+and+Intervention&rft.au=O%27Keeffe%2C+Mary+K%3BNesselhof-Kendall%2C+Sarah%3BBaum%2C+Andrew&rft.aulast=O%27Keeffe&rft.aufirst=Mary&rft.date=1990-03-01&rft.volume=16&rft.issue=1&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Personality+and+Social+Psychology+Bulletin&rft.issn=01461672&rft_id=info:doi/10.1177%2F0146167290161012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; vaccines; Psychology; social behavior; personality; attitudes; Education; Behavior; Human immunodeficiency virus; intervention; Reviews; infection; prevention DO - http://dx.doi.org/10.1177/0146167290161012 ER - TY - JOUR T1 - Humans and animals: increasing contacts, increasing infections. AN - 79620444; 2105969 AB - Changes in the zoonotic infections that affect Americans stem primarily from shifting patterns of animal-human interaction, the crossover of species-specific organisms, and the importation or identification of new organisms. Although Lyme disease is not, strictly speaking, zoonotic, it leads off this review by virtue of its epidemic or near-epidemic prevalence in many areas. JF - Hospital practice (Office ed.) AU - Sanford, J P AD - Uniformed Services University of the Health Sciences, Bethesda. Y1 - 1990/02/15/ PY - 1990 DA - 1990 Feb 15 SP - 123 EP - 30, 133-4, 137-40 VL - 25 IS - 2 SN - 8750-2836, 8750-2836 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Animals, Domestic KW - Animals KW - Humans KW - Lyme Disease KW - Food Contamination KW - Occupational Diseases KW - Disease Outbreaks KW - Zoonoses -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79620444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hospital+practice+%28Office+ed.%29&rft.atitle=Humans+and+animals%3A+increasing+contacts%2C+increasing+infections.&rft.au=Sanford%2C+J+P&rft.aulast=Sanford&rft.aufirst=J&rft.date=1990-02-15&rft.volume=25&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Hospital+practice+%28Office+ed.%29&rft.issn=87502836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-19 N1 - Date created - 1990-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of increased dietary calcium on the development of reduced renal mass saline hypertension in rats. AN - 79653691; 2307805 AB - A diet fortified with calcium carbonate has been reported to reduce blood pressure in low-renin and salt-sensitive hypertensive patients. We have therefore examined the effect of increased dietary calcium on the development of reduced renal mass-saline hypertension in rats, a classical, low-renin, volume, and sodium-dependent model of hypertension. Rats with 70-75% reduction in renal mass were divided into experimental and control groups. The experimental rats were fed a sodium-free diet supplemented with calcium carbonate (2.0% calcium) and drank 1% saline for 5 weeks. Control rats consumed the salt-free diet and drank 1% saline for the same period. In control rats, as previously observed, blood pressure progressive increased from a control value of 120.0 +/- 1.2 to 174.2 +/- 1.2 mm Hg by the fifth week. In contrast, in the calcium-supplemented rats the development of hypertension was significantly attenuated; the blood pressure only increased from 117.0 +/- 1.2 to 134.0 +/- 3.8 mm Hg by the fifth week. This was associated with a 30% decrease in saline intake by the fifth week, with proportionate decreases in urine volume and sodium excretion but not potassium excretion. Urinary magnesium excretion increased. No such changes were seen in control rats. At the end of the treatment period, plasma levels of sodium, potassium, calcium, creatinine, BUN, and protein were not different, but plasma chloride and magnesium were lower in experimental rats; vascular smooth muscle cell membrane potentials were also not different. These data show that dietary calcium carbonate can attenuate the development of reduced renal mass-saline hypertension in the rat, possibly in part by altering sodium and water intake. JF - Journal of the American College of Nutrition AU - Pamnani, M B AU - Chen, S AU - Bryant, H J AU - Schooley, J F AU - Haddy, F J AD - Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 35 EP - 43 VL - 9 IS - 1 SN - 0731-5724, 0731-5724 KW - Calcium, Dietary KW - 0 KW - Sodium KW - 9NEZ333N27 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Blood Pressure -- drug effects KW - Sodium -- administration & dosage KW - Sodium -- urine KW - Male KW - Sodium -- metabolism KW - Calcium, Dietary -- blood KW - Hypertension, Renal -- prevention & control KW - Calcium, Dietary -- pharmacology KW - Hypertension, Renal -- chemically induced KW - Calcium, Dietary -- administration & dosage KW - Hypertension, Renal -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79653691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Nutrition&rft.atitle=Effect+of+increased+dietary+calcium+on+the+development+of+reduced+renal+mass+saline+hypertension+in+rats.&rft.au=Pamnani%2C+M+B%3BChen%2C+S%3BBryant%2C+H+J%3BSchooley%2C+J+F%3BHaddy%2C+F+J&rft.aulast=Pamnani&rft.aufirst=M&rft.date=1990-02-01&rft.volume=9&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Nutrition&rft.issn=07315724&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-06 N1 - Date created - 1990-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Behavioral and psychological responses to chemical and biological warfare. AN - 79651935; 2106650 AB - Understanding the behavioral and psychological responses in a chemical environment is critical to individual health and unit functioning. Reports of incidents of acute nerve agent and other organophosphate exposures and of repeated low-dose toxic exposures can provide information about psychiatric symptomatology, performance disruption, and recovery. This paper presents a review of the literature on the longer term consequences of acute and chronic exposure to nerve agents and other organophosphates. In addition, reports on psychological responses during chemical warfare training are reanalyzed to identify behavioral and psychological casualties attributed to the unique stressors of the CBW environment. JF - Military medicine AU - Fullerton, C S AU - Ursano, R J AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 54 EP - 59 VL - 155 IS - 2 SN - 0026-4075, 0026-4075 KW - Organophosphorus Compounds KW - 0 KW - Index Medicus KW - Humans KW - Gas Poisoning KW - Stress, Psychological -- psychology KW - Chemical Warfare KW - Military Personnel -- psychology KW - Biological Warfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79651935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Behavioral+and+psychological+responses+to+chemical+and+biological+warfare.&rft.au=Fullerton%2C+C+S%3BUrsano%2C+R+J&rft.aulast=Fullerton&rft.aufirst=C&rft.date=1990-02-01&rft.volume=155&rft.issue=2&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-04-09 N1 - Date created - 1990-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Functional analysis of the Shiga toxin and Shiga-like toxin type II variant binding subunits by using site-directed mutagenesis. AN - 79595025; 2404947 AB - The B subunit of Shiga toxin and the Shiga-like toxins (SLTs) mediates receptor binding, cytotoxic specificity, and extracellular localization of the holotoxin. While the functional receptor for Shiga toxin, SLT type I (SLT-I), and SLT-II is the glycolipid designated Gb3, SLT-II variant (SLT-IIv) may use a different glycolipid receptor. To identify the domains responsible for receptor binding, localization in Escherichia coli, and recognition by neutralizing monoclonal antibodies, oligonucleotide-directed site-specific mutagenesis was used to alter amino acid residues in the B subunits of Shiga toxin and SLT-IIv. Mutagenesis of a well-conserved hydrophilic region near the amino terminus of the Shiga toxin B subunit rendered the molecule nontoxic but did not affect immunoreactivity or holotoxin assembly. In addition, elimination of one cysteine residue, as well as truncation of the B polypeptide by 5 amino acids, caused a total loss of activity. Changing a glutamate to a glutamine at the carboxyl terminus of the Shiga toxin B subunit resulted in the loss of receptor binding and immunoreactivity. However, the corresponding mutation in the SLT-IIv B subunit (glutamine to glutamate) did not reduce the levels of cytotoxicity but did affect extracellular localization of the holotoxin in E. coli. JF - Journal of bacteriology AU - Jackson, M P AU - Wadolkowski, E A AU - Weinstein, D L AU - Holmes, R K AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 653 EP - 658 VL - 172 IS - 2 SN - 0021-9193, 0021-9193 KW - Bacterial Toxins KW - 0 KW - Macromolecular Substances KW - Oligonucleotide Probes KW - Receptors, Cell Surface KW - Receptors, Immunologic KW - Shiga Toxins KW - shigella toxin receptor KW - Index Medicus KW - Animals KW - HeLa Cells -- drug effects KW - Humans KW - Operon KW - Amino Acid Sequence KW - Plasmids KW - HeLa Cells -- cytology KW - Binding Sites KW - Base Sequence KW - Cell Survival -- drug effects KW - Restriction Mapping KW - Molecular Sequence Data KW - Cell Line KW - Bacterial Toxins -- genetics KW - Genetic Variation KW - Bacterial Toxins -- metabolism KW - Shigella dysenteriae -- genetics KW - Receptors, Immunologic -- metabolism KW - Bacterial Toxins -- pharmacology KW - Mutation KW - Shigella dysenteriae -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79595025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Functional+analysis+of+the+Shiga+toxin+and+Shiga-like+toxin+type+II+variant+binding+subunits+by+using+site-directed+mutagenesis.&rft.au=Jackson%2C+M+P%3BWadolkowski%2C+E+A%3BWeinstein%2C+D+L%3BHolmes%2C+R+K%3BO%27Brien%2C+A+D&rft.aulast=Jackson&rft.aufirst=M&rft.date=1990-02-01&rft.volume=172&rft.issue=2&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-14 N1 - Date created - 1990-03-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Infect Dis. 1986 Aug;154(2):338-41 [3522760] Infect Immun. 1983 Jul;41(1):430-3 [6345399] J Biol Chem. 1987 Feb 5;262(4):1779-85 [3543013] J Biol Chem. 1987 Apr 15;262(11):5398-403 [3558397] J Mol Biol. 1965 Dec;14(2):528-33 [5880864] Nature. 1970 Aug 15;227(5259):680-5 [5432063] J Immunol. 1975 Dec;115(6):1617-24 [1102604] J Mol Biol. 1976 Jul 5;104(3):541-55 [781293] Cell. 1977 Mar;10(3):521-36 [403011] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] Science. 1987 Jun 5;236(4806):1252-8 [3296192] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] Biochem Biophys Res Commun. 1988 Apr 29;152(2):674-9 [3284526] J Mol Biol. 1980 Oct 25;143(2):161-78 [6260957] Infect Immun. 1989 Dec;57(12):3743-50 [2807546] DNA. 1984 Dec;3(6):479-88 [6096101] Infect Immun. 1985 Dec;50(3):695-700 [3905611] Infect Immun. 1988 Jun;56(6):1618-24 [3286503] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] J Biol Chem. 1989 Jan 5;264(1):596-601 [2642481] Biochem Biophys Res Commun. 1989 Apr 14;160(1):126-32 [2653314] J Biol Chem. 1989 Jul 25;264(21):12520-5 [2663859] J Biol Chem. 1986 Oct 25;261(30):13928-31 [3771511] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Discrete localization of high-density 5-HT1A binding sites in the midline raphe and parapyramidal region of the ventral medulla oblongata of the rat. AN - 79623590; 2137565 AB - Serotonergic agonists that interact with the 5-HT1A receptor subtype cause marked decreases in blood pressure when administered to the medulla oblongata. In the present study, specific binding of the 5-HT1A-specific ligand, [3H]8-OH-DPAT, was determined in sections of the rat medulla oblongata using autoradiographic techniques. The highest density of binding was associated with the midline raphe nuclei and the parapyramidal regions of the rostral ventral medulla, areas that contain serotonergic neurons. Administration of the serotonergic neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT), 2 weeks prior to sacrifice, resulted in a marked loss of binding in the medullary raphe nuclei and the parapyramidal region. These results demonstrate the presence of 5-HT1A binding sites in discrete regions of the ventral medulla and are consistent with the hypothesis that 5-HT1A agonists reduce blood pressure by directly suppressing the activity of serotonergic neurons in the ventral medulla. JF - Neuroscience letters AU - Thor, K B AU - Blitz-Siebert, A AU - Helke, C J AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1990/01/22/ PY - 1990 DA - 1990 Jan 22 SP - 249 EP - 254 VL - 108 IS - 3 SN - 0304-3940, 0304-3940 KW - Naphthalenes KW - 0 KW - Receptors, Serotonin KW - Tetrahydronaphthalenes KW - 5,7-Dihydroxytryptamine KW - 31363-74-3 KW - 8-Hydroxy-2-(di-n-propylamino)tetralin KW - 78950-78-4 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - 5,7-Dihydroxytryptamine -- pharmacology KW - Male KW - Naphthalenes -- metabolism KW - Tetrahydronaphthalenes -- metabolism KW - Receptors, Serotonin -- metabolism KW - Raphe Nuclei -- metabolism KW - Medulla Oblongata -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79623590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Discrete+localization+of+high-density+5-HT1A+binding+sites+in+the+midline+raphe+and+parapyramidal+region+of+the+ventral+medulla+oblongata+of+the+rat.&rft.au=Thor%2C+K+B%3BBlitz-Siebert%2C+A%3BHelke%2C+C+J&rft.aulast=Thor&rft.aufirst=K&rft.date=1990-01-22&rft.volume=108&rft.issue=3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-26 N1 - Date created - 1990-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protein kinase C activation in B cells by indolactam inhibits anti-Ig-mediated phosphatidylinositol bisphosphate hydrolysis but not B cell proliferation. AN - 79544108; 2153169 AB - In order to examine the role of phosphatidylinositol bisphosphate (PIP2) hydrolysis in B cell activation, we studied the effect of various classes of protein kinase C (PKC) activators on anti-Ig-mediated B cell stimulation. Anti-Ig-stimulated PIP2 hydrolysis, elevations in [Ca2+]i, and induction of DNA synthesis were inhibited by PMA (a phorbol ester) as previously reported. In contrast, indolactam (an alkaloid PKC activator) inhibited PIP2 hydrolysis and elevations in [Ca2+]i, but stimulated rather than inhibited cellular proliferation. In order to examine whether the binding avidity of the PKC activators to PKC played a role in determining their activity to stimulate or inhibit B cell activation, we studied two other PKC activators, bryostatin and mezerein. Again, both inhibited anti-Ig mediated PIP2 hydrolysis and elevations in [Ca2+]i, whereas only the former inhibited induction of DNA synthesis. These data suggest that a) high levels of PIP2 hydrolysis and elevations in [Ca2+]i are not essential for anti-Ig-mediated induction of B cell DNA synthesis and b) activation of PKC may induce both stimulatory and inhibitory pathways of B cell activation, and whether stimulation or inhibition of cell activation is observed may depend on the combined intensity of these two signals. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Mond, J J AU - Balapure, A AU - Feuerstein, N AU - June, C H AU - Brunswick, M AU - Lindsberg, M L AU - Witherspoon, K AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1990/01/15/ PY - 1990 DA - 1990 Jan 15 SP - 451 EP - 455 VL - 144 IS - 2 SN - 0022-1767, 0022-1767 KW - Antibodies, Anti-Idiotypic KW - 0 KW - Bryostatins KW - Diterpenes KW - Immunoglobulin delta-Chains KW - Indoles KW - Lactams KW - Lactones KW - Macrolides KW - Phosphatidylinositol 4,5-Diphosphate KW - Phosphatidylinositols KW - Receptors, Antigen, B-Cell KW - Terpenes KW - mezerein KW - 34807-41-5 KW - bryostatin 1 KW - 37O2X55Y9E KW - Ionomycin KW - 56092-81-0 KW - indolactam V KW - 8CIY9O1323 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Phosphatidylinositols -- metabolism KW - Animals KW - Ionomycin -- pharmacology KW - Mice KW - Immunoglobulin delta-Chains -- immunology KW - Lactones -- pharmacology KW - Mice, Inbred DBA KW - Calcium -- metabolism KW - In Vitro Techniques KW - Antibodies, Anti-Idiotypic -- immunology KW - Enzyme Activation -- drug effects KW - Terpenes -- pharmacology KW - Receptors, Antigen, B-Cell -- physiology KW - Signal Transduction KW - Protein Kinase C -- metabolism KW - Lymphocyte Activation -- drug effects KW - Indoles -- pharmacology KW - B-Lymphocytes -- physiology KW - Lactams -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79544108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Protein+kinase+C+activation+in+B+cells+by+indolactam+inhibits+anti-Ig-mediated+phosphatidylinositol+bisphosphate+hydrolysis+but+not+B+cell+proliferation.&rft.au=Mond%2C+J+J%3BBalapure%2C+A%3BFeuerstein%2C+N%3BJune%2C+C+H%3BBrunswick%2C+M%3BLindsberg%2C+M+L%3BWitherspoon%2C+K&rft.aulast=Mond&rft.aufirst=J&rft.date=1990-01-15&rft.volume=144&rft.issue=2&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-09 N1 - Date created - 1990-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Comparison of the erbium-yttrium aluminum garnet and carbon dioxide lasers for in vitro bone and cartilage ablation. AN - 85188733; pmid-2104551 AB - The in vitro bone- and cartilage-ablation characteristics of the solid-state erbium:yttrium aluminum garnet laser were compared to those of the carbon dioxide laser. Ablations of fresh, frozen cadaver septal cartilage and maxillary sinus bone were performed using total energies between 1 and 6 J. Specimens were studied using hematoxylin and eosin stain and digitized, computer-assisted measurements of 35-mm photographs. Erbium-yttrium aluminum garnet-ablated bone averaged 5 microns of adjacent tissue thermal injury, compared with 67 microns with carbon dioxide-ablated bone. Erbium-yttrium aluminum garnet-ablated cartilage averaged 2 microns of adjacent tissue thermal injury, compared with 21 microns with the carbon dioxide-ablated cartilage. The tissue-ablation characteristics of the erbium-yttrium aluminum garnet laser are promising for future otolaryngologic applications. JF - The Laryngoscope AU - Gonzalez, C AU - van de Merwe W P AU - Smith, M AU - Reinisch, L AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Md. 20814-4799. PY - 1990 SP - 14 EP - 17 VL - 100 IS - 1 SN - 0023-852X, 0023-852X KW - Bone and Bones KW - Comparative Study KW - Cartilage KW - Human KW - Aluminum KW - Yttrium KW - Carbon Dioxide KW - Erbium KW - Laser Surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85188733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Comparison+of+the+erbium-yttrium+aluminum+garnet+and+carbon+dioxide+lasers+for+in+vitro+bone+and+cartilage+ablation.&rft.au=Gonzalez%2C+C%3Bvan+de+Merwe+W+P%3BSmith%2C+M%3BReinisch%2C+L&rft.aulast=Gonzalez&rft.aufirst=C&rft.date=1990-01-01&rft.volume=100&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Absolute configuration of cis-5,6-dihydrodiol enantiomers derived from helical conformers of 1,12-dimethylbenz[a]anthracene. AN - 79998973; 2119208 AB - 1,12-Dimethylbenz[a]anthracene (1,12-DMBA) cis-5,6-dihydrodiol was synthesized by oxidation of 1,12-DMBA with osmium tetroxide in pyridine in low yield (less than or equal to 3%) and was purified by sequential use of reversed-phase and normal-phase HPLC. Two pairs of 1,12-DMBA cis-5,6-dihydrodiol enantiomers, derived from P (right-handed helix) and M (left-handed helix) conformers, were eluted as a single chromatographic peak on both reversed-phase and normal-phase HPLC. However, these four enantiomers were resolved by sequential use of two chiral stationary phase (CSP) HPLC columns. CSP (Pirkle type I) columns were packed with either (R)-N-(3,5-dinitrobenzoyl)phenylglycine or (S)-N-(3,5-dinitrobenzoyl)leucine, which is ionically bonded to gamma-aminopropylsilanized silica. Absolute configurations of enantiomers were determined by comparing their circular dichroism spectra with those of conformationally similar cis-5,6-dihydrodiol enantiomers of 4-methylbenz[a]anthracene and 7,12-dimethylbenz[a]anthracene with known absolute stereochemistry. JF - Chirality AU - Yang, S K AU - Mushtaq, M AU - Fu, P P AD - Department of Pharmacology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1990 PY - 1990 DA - 1990 SP - 58 EP - 64 VL - 2 IS - 1 SN - 0899-0042, 0899-0042 KW - 7,12-dimethylbenz(a)anthracene-dihydrodiol KW - 2518-00-5 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Index Medicus KW - Mass Spectrometry KW - Stereoisomerism KW - Spectrophotometry, Ultraviolet KW - Circular Dichroism KW - Molecular Conformation KW - 9,10-Dimethyl-1,2-benzanthracene -- analysis KW - Chromatography, High Pressure Liquid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79998973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chirality&rft.atitle=Absolute+configuration+of+cis-5%2C6-dihydrodiol+enantiomers+derived+from+helical+conformers+of+1%2C12-dimethylbenz%5Ba%5Danthracene.&rft.au=Yang%2C+S+K%3BMushtaq%2C+M%3BFu%2C+P+P&rft.aulast=Yang&rft.aufirst=S&rft.date=1990-01-01&rft.volume=2&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Chirality&rft.issn=08990042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-19 N1 - Date created - 1990-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The evaluation of the abuse liability of drugs. AN - 79705979; 2182063 AB - In order to place appropriate restrictions upon the availability of certain therapeutic agents to limit their abuse, it is important to assess abuse liability, an important aspect of drug safety evaluation. However, the negative consequences of restriction must also be considered. Drugs most likely to be tested are psychoactive compounds with therapeutic indications similar to known drugs of abuse. Methods include assays of pharmacological profile, drug discrimination procedures, self-administration procedures, and measures of drug-induced toxicity including evaluations of tolerance and physical dependence. Furthermore, the evaluation of toxicity using behavioural end-points is an important component of the assessment, and it is generally believed that the most valid procedure in this evaluation is the measurement of drug self-administration. However, even this method rarely predicts the extent of abuse of a specific drug. Although methods are available which appear to measure relative abuse liability, these procedures are not validated for all drug classes. Thus, additional strategies, including abuse liability studies in humans, modelled after those used with animals, must be used in order to make a more informed prediction. Although there is pressure to place restrictions on new drugs at the time of marketing, in light of the difficulty of predicting relative abuse potential, a better strategy might be to market a drug without restrictions, but require postmarketing surveillance in order to obtain more accurate information on which to base a final decision. JF - Drug safety AU - Johanson, C E AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1990 PY - 1990 DA - 1990 SP - 46 EP - 57 VL - 5 Suppl 1 SN - 0114-5916, 0114-5916 KW - Index Medicus KW - Animals KW - Self Administration KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79705979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=The+evaluation+of+the+abuse+liability+of+drugs.&rft.au=Johanson%2C+C+E&rft.aulast=Johanson&rft.aufirst=C&rft.date=1990-01-01&rft.volume=5+Suppl+1&rft.issue=&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-05-16 N1 - Date created - 1990-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cardiovascular effects of anatoxin-A in the conscious rat. AN - 79587759; 2104994 AB - The effects of anatoxin-A on mean arterial pressure (MAP), heart rate, cardiac index (CI), and blood flow (BF) in hindquarter (HQ), renal (R), and mesenteric (M) vascular beds were studied after intravenous (iv) and intracerebroventricular (icv) administration in the conscious rat. The pharmacological profile of anatoxin-A was further compared to nicotine administered iv and icv. MAP and heart rate were measured from femoral artery, CI by thermodilution method, and blood flow by Doppler velocimetry. Anatoxin-A and nicotine (30, 100 and 300 micrograms/kg iv) produced an increase in MAP with concomitant bradycardia. The highest doses increased CI. MBF and RBF decreased due to a vasoconstriction in M and R vasculature. These effects were attenuated by the ganglion blocker chlorisondamine (5 mg/kg, iv). Anatoxin-A (100 micrograms/kg, iv) increased plasma epinephrine levels by 2-fold with virtually no effect on norepinephrine whereas nicotine (100 micrograms/kg, iv) increased plasma epinephrine and norepinephrine by 20- to 30-fold. Central administration of anatoxin-A and nicotine (30-100 micrograms/kg icv) increased MAP with no effect on heart rate and produced M and R vasoconstriction. In summary, the present study demonstrates that anatoxin-A acts as a nicotinic cholinergic agonist in the conscious rat after both systemic and central administration. Anatoxin-A and nicotine produced pressor and reno-splanchnic vasoconstrictor responses and at high doses increased cardiac output. These effects were mediated by activation of the nicotinic receptors in the adrenal medulla and sympathetic ganglia. However, marked differences were found in the potency of anatoxin-A versus nicotine to stimulate the sympathoadrenomedullary axis. JF - Toxicology and applied pharmacology AU - Sirén, A L AU - Feuerstein, G AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1990/01// PY - 1990 DA - January 1990 SP - 91 EP - 100 VL - 102 IS - 1 SN - 0041-008X, 0041-008X KW - Bacterial Toxins KW - 0 KW - Catecholamines KW - Marine Toxins KW - Microcystins KW - Tropanes KW - cyanobacterial toxin KW - Nicotine KW - 6M3C89ZY6R KW - anatoxin a KW - 80023A73NK KW - Index Medicus KW - Animals KW - Renal Circulation -- drug effects KW - Splanchnic Circulation -- drug effects KW - Regional Blood Flow -- drug effects KW - Vascular Resistance -- drug effects KW - Cardiac Output -- drug effects KW - Injections, Intraventricular KW - Rats KW - Rats, Inbred Strains KW - Cardiac Output -- physiology KW - Hindlimb -- blood supply KW - Cardiovascular Physiological Phenomena KW - Catecholamines -- blood KW - Nicotine -- pharmacology KW - Renal Circulation -- physiology KW - Splanchnic Circulation -- physiology KW - Vascular Resistance -- physiology KW - Regional Blood Flow -- physiology KW - Male KW - Marine Toxins -- pharmacology KW - Cyanobacteria KW - Wakefulness -- physiology KW - Wakefulness -- drug effects KW - Cardiovascular System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79587759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Cardiovascular+effects+of+anatoxin-A+in+the+conscious+rat.&rft.au=Sir%C3%A9n%2C+A+L%3BFeuerstein%2C+G&rft.aulast=Sir%C3%A9n&rft.aufirst=A&rft.date=1990-01-01&rft.volume=102&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-02-22 N1 - Date created - 1990-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The mitochondrial ATP synthase of Trypanosoma brucei : isolation and characterization of the intact F sub(1) moiety. AN - 15867971; 2461885 AB - This report describes the first isolation and molecular characterization of the mitochondrial F sub(1)-ATPase from Trypanosoma brucei). The isolation procedure utilized is a modified chloroform extraction procedure. In contrast to earlier reports on the F sub(1)-ATPase from other trypanosomatids, the F sub(1)-ATPase we have isolated from the procyclic form of T. brucei) a complex composed of five distinct subunits. Apparent molecular weights of these subunits are 55 000 ( alpha ), 42 000 ( beta ), 32 000 ( gamma ) 22 000 ( delta ), and 17 000 ( epsilon ). the F sub(1) moiety which possesses the active site of the H super(+)-ATPase has an ATPase activity in the standard Tris-HCl coupled enzyme assay with a V sub(max) of 22.96 mu mol/min/(mg protein) and a K sub(m) value of 0.60 mM. This ATPase activity is cold labile and is not susceptible to oligomycin inhibition as is the membrane bound enzyme. Upon reconstitution with F sub(1)-ATPase depleted membranes (urea particles) the ATPase regains oligomycin sensitivity to the same extent as the found in the intact inner membrane vesicles. ATP synthesis is also restored to these particles upon reconstitution with F sub(1). This F sub(1)-ATPase as isolated is intact with respect to all the critical H super(+)-ATPase functions. JF - Molecular and Biochemical Parasitology AU - Williams, N AU - Frank, PH AD - USUHS, Dep. Biochem., 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA Y1 - 1990 PY - 1990 DA - 1990 SP - 125 EP - 132 VL - 43 IS - 1 SN - 0166-6851, 0166-6851 KW - ATP synthase KW - Trypanosoma brucei KW - kinetics KW - mitochondria KW - molecular weight KW - purification KW - subunits KW - trypanosomiasis KW - Biochemistry Abstracts 3: Amino Acids, Peptides & Proteins (till 1993); Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - K 03022:Protozoa UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15867971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Biochemical+Parasitology&rft.atitle=The+mitochondrial+ATP+synthase+of+Trypanosoma+brucei+%3A+isolation+and+characterization+of+the+intact+F+sub%281%29+moiety.&rft.au=Williams%2C+N%3BFrank%2C+PH&rft.aulast=Williams&rft.aufirst=N&rft.date=1990-01-01&rft.volume=43&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Biochemical+Parasitology&rft.issn=01666851&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - mitochondria; molecular weight; trypanosomiasis ER - TY - JOUR T1 - Extensive photodimerization of non-adjacent pyrimidines. AN - 79443833; 2614847 AB - In a prior study we found that non-adjacent thymidyl residues in the single-stranded alternating copolymer poly[d(G-T)] are subject to photodimerization by germicidal lamp irradiation (lambda max 254 nm). The maximum yield of this photoproduct was 1% of the total thymine of poly[d(G-T)]. We now report that dimer formation in this polymer is increased to 10 to 40% thymine as dimer between non-adjacent pyrimidines, using near-ultraviolet irradiation (lambda max 310 nm) with or without acetone triplet-sensitization. As previously observed for 254 nm irradiation, dimer formation was nearly absent in double-stranded poly[d(G-T).d(C-A)]. These observations extend prior findings by demonstrating high-yield dimerization between non-adjacent pyrimidines via direct irradiation at environmentally relevant wavelengths (greater than or equal to 280 nm), and are potentially relevant to the mechanism of the ultraviolet light-induced targeted -1 frameshift mutation. JF - Journal of molecular biology AU - Nguyen, H T AU - Minton, K W AD - Department of Pathology, F. E. Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1989/12/20/ PY - 1989 DA - 1989 Dec 20 SP - 869 EP - 874 VL - 210 IS - 4 SN - 0022-2836, 0022-2836 KW - Polydeoxyribonucleotides KW - 0 KW - Pyrimidine Dimers KW - Acetone KW - 1364PS73AF KW - poly(d(G-T).d(C-A)) KW - 85824-40-4 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Ultraviolet Rays KW - Polydeoxyribonucleotides -- radiation effects KW - Dose-Response Relationship, Radiation KW - DNA -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79443833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Extensive+photodimerization+of+non-adjacent+pyrimidines.&rft.au=Nguyen%2C+H+T%3BMinton%2C+K+W&rft.aulast=Nguyen&rft.aufirst=H&rft.date=1989-12-20&rft.volume=210&rft.issue=4&rft.spage=869&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-14 N1 - Date created - 1990-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The safety of phenylpropanolamine in patients with stable hypertension. AN - 79376189; 2688505 JF - Annals of internal medicine AU - Kroenke, K AU - Omori, D M AU - Simmons, J O AU - Wood, D R AU - Meier, N J AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1989/12/15/ PY - 1989 DA - 1989 Dec 15 SP - 1043 EP - 1044 VL - 111 IS - 12 SN - 0003-4819, 0003-4819 KW - Phenylpropanolamine KW - 33RU150WUN KW - Abridged Index Medicus KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Phenylpropanolamine -- adverse effects KW - Hypertension -- physiopathology KW - Blood Pressure -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79376189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=The+safety+of+phenylpropanolamine+in+patients+with+stable+hypertension.&rft.au=Kroenke%2C+K%3BOmori%2C+D+M%3BSimmons%2C+J+O%3BWood%2C+D+R%3BMeier%2C+N+J&rft.aulast=Kroenke&rft.aufirst=K&rft.date=1989-12-15&rft.volume=111&rft.issue=12&rft.spage=1043&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-12 N1 - Date created - 1990-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - In vivo formation of hybrid toxins comprising Shiga toxin and the Shiga-like toxins and role of the B subunit in localization and cytotoxic activity. AN - 79282082; 2807546 AB - Shiga toxin, Shiga-like toxin I (SLT-I) and Shiga-like toxin II (SLT-II) are cell-associated cytotoxins that kill both Vero cells and HeLa cells, whereas Shiga-like toxin II variant (SLT-IIv) is an extracellular cytotoxin that is more cytotoxic for Vero cells than for HeLa cells. The basis for these differences in cytotoxin localization and host cell specificity were examined in this study. The A and B subunit genes of Shiga toxin and the SLTs were recombined by two methods so that hybrid toxins would be formed in vivo. Complementation of heterologous subunits was accomplished by cloning the individual A and B subunit genes of SLT-I, SLT-II, and SLT-IIv on plasmid vectors of different incompatibility groups so that they could be maintained in double transformants of Escherichia coli. In addition, six operon fusions were constructed so that the A and B subunit genes of Shiga toxin, SLT-II, and SLT-IIv could be expressed as a single operon. The activities of the hybrid cytotoxins were assessed in three ways: (i) level of cytotoxicity, (ii) ratio of HeLa to Vero cell cytotoxicity, and (iii) ratio of extracellular to cell-associated cytotoxicity. Neither the A subunit of Shiga toxin nor SLT-I associated with a heterologous B subunit to form an active cytotoxin. However, in all other cases the hybrid molecules formed by subunit complementation or operon fusion were cytotoxic. Furthermore, the cytotoxic specificity and localization of the hybrid cytotoxins always corresponded to the activities of the native toxin possessing the same B subunit. JF - Infection and immunity AU - Weinstein, D L AU - Jackson, M P AU - Perera, L P AU - Holmes, R K AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 3743 EP - 3750 VL - 57 IS - 12 SN - 0019-9567, 0019-9567 KW - Bacterial Toxins KW - 0 KW - Macromolecular Substances KW - Recombinant Proteins KW - Shiga Toxin 1 KW - Shiga Toxin 2 KW - Shiga Toxins KW - Index Medicus KW - DNA Mutational Analysis KW - Humans KW - Shigella KW - Cells, Cultured -- drug effects KW - Structure-Activity Relationship KW - Cell Survival -- drug effects KW - In Vitro Techniques KW - Restriction Mapping KW - Genetic Complementation Test KW - Bacterial Toxins -- genetics KW - Bacterial Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79282082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=In+vivo+formation+of+hybrid+toxins+comprising+Shiga+toxin+and+the+Shiga-like+toxins+and+role+of+the+B+subunit+in+localization+and+cytotoxic+activity.&rft.au=Weinstein%2C+D+L%3BJackson%2C+M+P%3BPerera%2C+L+P%3BHolmes%2C+R+K%3BO%27Brien%2C+A+D&rft.aulast=Weinstein&rft.aufirst=D&rft.date=1989-12-01&rft.volume=57&rft.issue=12&rft.spage=3743&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1987 Feb 5;262(4):1779-85 [3543013] J Infect Dis. 1986 Aug;154(2):338-41 [3522760] J Biol Chem. 1987 Jun 25;262(18):8834-9 [3298243] Infect Immun. 1987 Nov;55(11):2675-80 [2822579] Eur J Biochem. 1988 Jan 15;171(1-2):45-50 [3276522] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] Biochem Biophys Res Commun. 1988 Apr 29;152(2):674-9 [3284526] Infect Immun. 1988 Aug;56(8):1926-33 [3294179] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] J Clin Microbiol. 1988 Oct;26(10):2127-31 [3053764] J Biol Chem. 1989 Jan 5;264(1):596-601 [2642481] Microb Pathog. 1988 Sep;5(3):189-95 [3063913] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] J Bacteriol. 1978 Jun;134(3):1141-56 [149110] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] J Mol Biol. 1980 Oct 25;143(2):161-78 [6260957] J Biol Chem. 1981 Aug 25;256(16):8732-8 [7021550] J Biol Chem. 1981 Aug 25;256(16):8739-44 [6894922] Gene. 1982 Jan;17(1):79-89 [6281139] J Infect Dis. 1982 Dec;146(6):763-9 [6754826] Infect Immun. 1983 May;40(2):675-83 [6341244] Proc Natl Acad Sci U S A. 1983 Jul;80(13):3963-5 [6575390] DNA. 1984 Dec;3(6):479-88 [6096101] J Exp Med. 1984 Dec 1;160(6):1767-81 [6392471] Eur J Biochem. 1985 Apr 15;148(2):265-70 [3838723] Science. 1985 Oct 11;230(4722):179-81 [2994228] Infect Immun. 1985 Dec;50(3):695-700 [3905611] J Gen Microbiol. 1985 Nov;131(11):3047-53 [3005476] J Exp Med. 1986 Jun 1;163(6):1391-404 [3519828] Infect Immun. 1986 Jul;53(1):135-40 [3522426] J Biol Chem. 1987 Jun 15;262(17):8128-30 [3036799] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Is terminal deoxynucleotidyl transferase an intracellular mutagen? AN - 79356521; 2590226 AB - We have established stably transformed mammalian cell lines expressing recombinant human terminal deoxynucleotidyl transferase. A 58 kDa, enzymatically active protein is produced by these cell lines. Using the lacI gene of pJYMib shuttle vector as mutagenic target, we found no increase in mutation rates in cells expressing terminal deoxynucleotidyl transferase compared to controls. Our results suggest that the presence of terminal deoxynucleotidyl transferase alone in mammalian cells does not increase mutation rates. JF - Biochemical and biophysical research communications AU - Chang, L M AU - Rusquet-Valerius, R AU - Roy, N K AU - Cheung, L C AU - Bollum, F J AD - Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1989/11/30/ PY - 1989 DA - 1989 Nov 30 SP - 271 EP - 277 VL - 165 IS - 1 SN - 0006-291X, 0006-291X KW - Mutagens KW - 0 KW - DNA Nucleotidylexotransferase KW - EC 2.7.7.31 KW - Index Medicus KW - Animals KW - Genes KW - Humans KW - Gene Expression KW - Mice KW - Mammary Neoplasms, Experimental -- enzymology KW - Plasmids KW - Cell Line KW - Transfection KW - DNA Nucleotidylexotransferase -- metabolism KW - Tumor Cells, Cultured -- enzymology KW - DNA Nucleotidylexotransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79356521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Is+terminal+deoxynucleotidyl+transferase+an+intracellular+mutagen%3F&rft.au=Chang%2C+L+M%3BRusquet-Valerius%2C+R%3BRoy%2C+N+K%3BCheung%2C+L+C%3BBollum%2C+F+J&rft.aulast=Chang&rft.aufirst=L&rft.date=1989-11-30&rft.volume=165&rft.issue=1&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-11 N1 - Date created - 1990-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Lesions of the basal forebrain alter stimulus-evoked metabolic activity in mouse somatosensory cortex. AN - 79231815; 2551936 AB - The role that acetylcholine plays in processing sensory stimuli is beginning to be characterized; however, morphological correlates of cholinergic effects on activity patterns in sensory cortex are not available. To study this problem, unilateral neurotoxic lesions that depleted the necortex of acetylcholine were made in the basal forebrains of mice. The aim of these experiments was to study the effect of cholinergic depletion on stimulus-evoked activity in the barrel field of the mouse somatosensory cortex. One month following the lesion, 2-deoxyglucose (2DG) experiments were conducted on the lesioned and on normal mice while the animal received bilateral stimulation to the C3 whisker. The tissue was processed for acetylcholinesterase and cytochrome oxidase histochemistry and 2DG autoradiography. Evaluation of the column-like 2DG label evoked in the somatosensory cortex revealed that the activity on the lesioned side was significantly reduced in dimension and intensity from that in the normal hemisphere. On the normal side, the activated barrels averaged 641 microns in tangential width, were 76.5% above background in density, and extended from lamina I-V. On the lesioned side, the activated barrels were 485 microns in tangential width, 65.4% above background in density, and extended from lamina II-V. In other cortical regions, outside the stimulus-evoked barrel field, 2DG activity values were similar on the normal and lesioned side. Additionally, both the pattern and intensity of the cytochrome oxidase staining within the barrel field displayed no differences in either hemisphere. These studies suggest that acetylcholine plays a significant role in the processing of somatosensory information. Neurotoxic lesions that diminish cortical cholinergic innervation cause a reduction of stimulus-evoked activity levels, while underlying metabolic activity is either not affected or recovers over time. JF - The Journal of comparative neurology AU - Ma, W AU - Höhmann, C F AU - Coyle, J T AU - Juliano, S L AD - Department of Anatomy, USUHS, Bethesda, Maryland 20814. Y1 - 1989/10/15/ PY - 1989 DA - 1989 Oct 15 SP - 414 EP - 427 VL - 288 IS - 3 SN - 0021-9967, 0021-9967 KW - Deoxyglucose KW - 9G2MP84A8W KW - Electron Transport Complex IV KW - EC 1.9.3.1 KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Animals KW - Mice KW - Male KW - Acetylcholine -- physiology KW - Olivary Nucleus -- physiology KW - Mice, Inbred BALB C -- metabolism KW - Somatosensory Cortex -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79231815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+comparative+neurology&rft.atitle=Lesions+of+the+basal+forebrain+alter+stimulus-evoked+metabolic+activity+in+mouse+somatosensory+cortex.&rft.au=Ma%2C+W%3BH%C3%B6hmann%2C+C+F%3BCoyle%2C+J+T%3BJuliano%2C+S+L&rft.aulast=Ma&rft.aufirst=W&rft.date=1989-10-15&rft.volume=288&rft.issue=3&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+comparative+neurology&rft.issn=00219967&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-22 N1 - Date created - 1989-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Pathogenicity of the Bacteroides fragilis group. AN - 79261058; 2679351 AB - The Bacteroides fragilis group is one of the most important pathogens in polymicrobial infections. The distribution of the different members of the B. fragilis group in clinical infections varies. Bacteroides fragilis accounts for 63 percent of all the group isolates, Bacteroides thetaiotaomicron for 14 percent, Bacteroides vulgatus and Bacteroides ovatus for seven percent each, Bacteroides distasonis for six percent and Bacteroides uniformis for two percent. All members of the group induced bacteremia that was associated with an average mortality of 27 percent. The B. fragilis group resist beta lactam antibiotics by producing the enzyme beta-lactamase. This enzyme can be detected in abscess fluid, and can interfere with the eradication of other bacteria that are susceptible to penicillins and cephalosporins. All members of the B. fragilis group can become encapsulated during an inflammatory process as was demonstrated in a subcutaneous abscess model in mice. Non-encapsulated strains can become encapsulated with the assistance of their aerobic counterparts. These encapsulated strains are more virulent to the host than non-encapsulated strains. This increased virulence can be demonstrated by a higher rate of induction of bacteremia, and a greater enhancement of growth of other bacteria in mixed infection. Antimicrobial therapy directed only at the eradication of the aerobic bacteria did not prevent encapsulation, or reduce the number of Bacteroides species. The virulence of all members of the B. fragilis group highlights the need to direct antimicrobial therapy against all members of this group. JF - Annals of clinical and laboratory science AU - Brook, I AD - Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-5145. PY - 1989 SP - 360 EP - 376 VL - 19 IS - 5 SN - 0091-7370, 0091-7370 KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Virulence KW - Penicillin Resistance KW - Animals KW - beta-Lactamases -- biosynthesis KW - Humans KW - Abscess -- microbiology KW - Lethal Dose 50 KW - Sepsis -- microbiology KW - Bacteroides Infections -- microbiology KW - Species Specificity KW - Bacteroides fragilis -- enzymology KW - Bacteroides fragilis -- isolation & purification KW - Bacteroides fragilis -- pathogenicity KW - Bacteroides fragilis -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79261058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+clinical+and+laboratory+science&rft.atitle=Pathogenicity+of+the+Bacteroides+fragilis+group.&rft.au=Brook%2C+I&rft.aulast=Brook&rft.aufirst=I&rft.date=1989-09-01&rft.volume=19&rft.issue=5&rft.spage=360&rft.isbn=&rft.btitle=&rft.title=Annals+of+clinical+and+laboratory+science&rft.issn=00917370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-01 N1 - Date created - 1989-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calculating the hazard function and probability of tumor for cancer risk assessment when the parameters are time-dependent. AN - 79255280; 2798985 AB - The probability of tumor and hazard function are calculated in a stochastic two-stage model for carcinogenesis when the parameters of the mode are time-dependent. The method used is called the method of characteristics. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Quinn, D W AD - Department of Mathematics and Computer Science, Air Force Institute of Technology, Wright-Patterson Air Force Base, Ohio 45433. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 407 EP - 413 VL - 9 IS - 3 SN - 0272-4332, 0272-4332 KW - Index Medicus KW - Probability KW - Risk Factors KW - Humans KW - Time Factors KW - Models, Biological KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79255280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Calculating+the+hazard+function+and+probability+of+tumor+for+cancer+risk+assessment+when+the+parameters+are+time-dependent.&rft.au=Quinn%2C+D+W&rft.aulast=Quinn&rft.aufirst=D&rft.date=1989-09-01&rft.volume=9&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=02724332&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-22 N1 - Date created - 1989-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Characterization of diphtheria toxin-induced lesions in liposomal membranes. An evaluation of the relationship between toxin insertion and "channel" formation. AN - 79125979; 2474531 AB - Diphtheria toxin interaction with membranes has been studied by following the release of a fluorescent dye (calcein) encapsulated within large unilamellar vesicles. Results showed that diphtheria toxin induced temperature- as well as pH-dependent permeability changes in these model membranes. Interestingly, insertion of the "channel-forming" B domain was not sufficient for calcein release, since dye release from vesicles composed of dimyristoyllecithin:cholesterol:dicetylphosphate 4:3:0.8) was completely inhibited at low temperatures which permitted B insertion. Rather, the temperature dependence of calcein release from and A domain insertion into dimyristoyllecithin:cholesterol:dicetyl phosphate vesicles suggest some relationship between "channel formation" and fragment A translocation across membranes. However, the nature of the toxin channel is called into question by our observations that channel size, in addition to activity, was pH-dependent. On the basis of these experiments, it is proposed that the toxin "channel" is the result of localized perturbations in the lipid bilayer at the interface between lipids and inserted toxin molecules that are sufficiently large in fluid membranes at low pH to allow the translocation of fragment A across the bilayer. JF - The Journal of biological chemistry AU - Jiang, G S AU - Solow, R AU - Hu, V W AD - Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1989/08/15/ PY - 1989 DA - 1989 Aug 15 SP - 13424 EP - 13429 VL - 264 IS - 23 SN - 0021-9258, 0021-9258 KW - Dextrans KW - 0 KW - Diphtheria Toxin KW - Fluoresceins KW - Indicators and Reagents KW - Ion Channels KW - Liposomes KW - Inulin KW - 9005-80-5 KW - Dimyristoylphosphatidylcholine KW - U86ZGC74V5 KW - fluorexon KW - V0YM2B16TS KW - Index Medicus KW - Spectrometry, Fluorescence KW - Kinetics KW - Hydrogen-Ion Concentration KW - Ion Channels -- physiology KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79125979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Characterization+of+diphtheria+toxin-induced+lesions+in+liposomal+membranes.+An+evaluation+of+the+relationship+between+toxin+insertion+and+%22channel%22+formation.&rft.au=Jiang%2C+G+S%3BSolow%2C+R%3BHu%2C+V+W&rft.aulast=Jiang&rft.aufirst=G&rft.date=1989-08-15&rft.volume=264&rft.issue=23&rft.spage=13424&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-11 N1 - Date created - 1989-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Deliberate epidural air injection in dogs: a radiographic study. AN - 79570549; 2491280 AB - To investigate whether and to what extent air bubbles are present in the epidural space after injections of air, the authors designed an experiment using a chronic dog model. The epidural space was entered at the sixth or seventh lumbar interspace in six mongrel dogs (weight, 20 to 27 kg). Loss-of-resistance (LOR) to saline was tested to identify the epidural space. Three milliliters of air were injected via a Tuohy needle, followed by 5 ml of contrast material (Isovue 300, Squibb Diagnostics). Anterior-posterior (AP) and lateral radiographs were taken on day 1. On days 2, 4, and 8, the procedure was repeated, omitting the air injection. Radiographs were read by a neuroradiologist. Air bubbles were radiographically demonstrated in all six dogs on day 1, and in three of six dogs on day 2. No air was seen on later films. The air bubbles seen were small and few in number but often located near intervertebral spaces. The authors' findings suggest that injection of large volumes of epidural air should be avoided, particularly when N2O is used as part of the anesthetic or when performing diagnostic peridurography since N2O may expand the volume of existing bubbles and interfere with filling of the epidural space by local anesthetics or contrast material. JF - Regional anesthesia AU - Stevens, R AU - Mikat-Stevens, M AU - Van Clief, M AU - Schubert, A AU - Weinstein, Z AD - Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. PY - 1989 SP - 180 EP - 182 VL - 14 IS - 4 SN - 0146-521X, 0146-521X KW - Index Medicus KW - Animals KW - Dogs KW - Radiography KW - Injections, Epidural -- adverse effects KW - Female KW - Epidural Space -- diagnostic imaging KW - Air UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79570549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regional+anesthesia&rft.atitle=Deliberate+epidural+air+injection+in+dogs%3A+a+radiographic+study.&rft.au=Stevens%2C+R%3BMikat-Stevens%2C+M%3BVan+Clief%2C+M%3BSchubert%2C+A%3BWeinstein%2C+Z&rft.aulast=Stevens&rft.aufirst=R&rft.date=1989-07-01&rft.volume=14&rft.issue=4&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Regional+anesthesia&rft.issn=0146521X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-11 N1 - Date created - 1991-04-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Reg Anesth. 1990 May-Jun;15(3):150-1 [2265171] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cancer of the breast and reproductive tract in relation to use of oral contraceptives. AN - 79195519; 2673658 AB - Effects of oral contraception on cancers of the female breast and reproductive tract are critically reviewed from human studies reported since 1980. The cumulative risk of breast cancer through 59 years of age appears to bear no relationship to oral contraceptive (OC) use whatsoever. Studies restricted to women under age 45, however, raise concern about a possible adverse effect from OC use before a first-term pregnancy. A duration-related protective effect against endometrial cancer occurs from use of combined OCs. The risk is reduced by about 40% with 2 years of use, and by about 60% with 4 or more years of oral contraception. Oral contraception in excess of 3 years protects against ovarian cancer. Four years of use confers a 50% reduction in risk and 7 or more years of use confers a 60%-80% reduction in ovarian cancer risk. Studies of cervical dysplasia and carcinoma in situ suggest elevated risks with 2 or more years of OC use, although results are difficult to interpret in view of numerous factors that might distort the findings. The risk of invasive cervical cancer appear to be unaffected by up to 5 years of oral contraception. Beyond this, there is evidence suggesting an elevated risk which approaches a 2-fold increase at 10 years of use. Cancers of the vagina and fallopian tube are extremely rare. Their risks have yet to be characterized in relation to oral contraception. JF - Contraception AU - Schlesselman, J J AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 1 EP - 38 VL - 40 IS - 1 SN - 0010-7824, 0010-7824 KW - Contraceptives, Oral KW - 0 KW - Index Medicus KW - Population KW - Measurement KW - Fertility KW - Age Factors KW - Contraception Continuation KW - Research Methodology KW - Population Dynamics KW - Physiology KW - Contraceptive Methods--side effects KW - Estrogens--side effects KW - Breast Cancer KW - Endometrial Cancer KW - Oral Contraceptives--side effects KW - Hormones KW - Cervical Effects KW - Body Weight KW - Genitalia, Female KW - Population Characteristics KW - Ovarian Cancer KW - Demographic Factors KW - Diseases KW - Literature Review KW - Family Planning KW - Parity KW - Obesity KW - Uterus KW - Contraceptive Methods--beneficial effects KW - Cervical Cancer KW - Oral Contraceptives--beneficial effects KW - Endocrine System KW - Genitalia KW - Cancer KW - Age Distribution KW - Neoplasms KW - Contraception KW - Risk Factors KW - Urogenital System KW - Incidence KW - Fertility Measurements KW - Contraceptive Usage KW - Cervix KW - Biology KW - Humans KW - Cohort Studies KW - Adult KW - Middle Aged KW - Neoplasms, Hormone-Dependent -- chemically induced KW - Adolescent KW - Female KW - Contraceptives, Oral -- adverse effects KW - Breast Neoplasms -- genetics KW - Genitalia, Female -- drug effects KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- chemically induced KW - Genital Neoplasms, Female -- genetics KW - Genital Neoplasms, Female -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79195519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contraception&rft.atitle=Cancer+of+the+breast+and+reproductive+tract+in+relation+to+use+of+oral+contraceptives.&rft.au=Schlesselman%2C+J+J&rft.aulast=Schlesselman&rft.aufirst=J&rft.date=1989-07-01&rft.volume=40&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Contraception&rft.issn=00107824&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-17 N1 - Date created - 1989-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bacteriology of chronic maxillary sinusitis in adults. AN - 85181051; pmid-2729825 AB - Aspirates of 72 chronically inflamed maxillary sinuses were processed for aerobic and anaerobic bacteria. Bacterial growth was present in 66 of the 72 specimens (92%). Anaerobic bacteria were isolated in 58 of the 66 culture-positive specimens (88%). Anaerobes only were recovered in 37 cases (56%) and in 21 (32%) they were mixed with aerobic or facultative bacteria. Aerobic or facultative bacteria were present in eight cases (12%). A total of 185 isolates (2.8 per specimen)--131 (2.0 per specimen) anaerobes and 54 (0.8 per specimen) aerobes or facultatives--were isolated. The predominant anaerobic organisms were anaerobic cocci and Bacteroides sp, and the predominant aerobes or facultatives were Streptococcus sp and Staphylococcus aureus. Twelve of the 27 Bacteroides sp that were tested for beta-lactamase (44%) produced the enzyme. These findings indicate the major role of anaerobic organisms in chronic sinusitis. JF - The Annals of Otology, Rhinology, and Laryngology AU - Brook, I AD - Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland. PY - 1989 SP - 426 EP - 428 VL - 98 IS - 6 SN - 0003-4894, 0003-4894 KW - Bacterial Infections KW - Maxillary Sinus KW - Bacteria, Anaerobic KW - Humans KW - Adult KW - Chronic Disease KW - Middle Aged KW - Sinusitis KW - Bacteria, Aerobic KW - Female KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85181051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Bacteriology+of+chronic+maxillary+sinusitis+in+adults.&rft.au=Brook%2C+I&rft.aulast=Brook&rft.aufirst=I&rft.date=1989-06-01&rft.volume=98&rft.issue=6&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mechanisms of hypotension produced by platelet-activating factor. AN - 79076845; 2745330 AB - Platelet-activating factor (PAF) is a phospholipid mediator that induces cardiovascular collapse and release of the secondary mediator thromboxane A2 (TxA2). To clarify mechanisms involved in this collapse and, specifically, the relative contribution of left ventricular and right ventricular dysfunction, we studied 12 open-chest pigs. PAF infusion (0.04-0.28 nmol.kg-1.min-1) induced a 5- to 120-fold increase in pulmonary vascular resistance, a 75-98% fall in cardiac output, and systemic arterial hypotension. Right ventricular failure was indicated by chamber enlargement, decreased shortening, and increased right atrial pressures. In contrast, left ventricular dysfunction was accompanied by decreases in chamber dimensions and filling pressures that were unresponsive to volume expansion. U 46619 (a stable TxA2 analogue) and mechanical pulmonary artery constriction induced changes similar to PAF. In 11 additional closed-chest pigs, TxA2 blockade with indomethacin attenuated the PAF-induced rise in pulmonary vascular resistance, right ventricular dysfunction, and systemic hypotension. A specific TxA2 synthase inhibitor, OKY-046, also diminished hemodynamic effects of PAF in six other pigs. Tachyphylaxis was not observed in five pigs repeatedly given PAF. We conclude that acute right ventricular failure as the result of severe increase in pulmonary vascular resistance is the primary mechanism early in the course of PAF-induced shock in the pig. PAF-induced release of TxA2 may contribute significantly to these events. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Laurindo, F R AU - Goldstein, R E AU - Davenport, N J AU - Ezra, D AU - Feuerstein, G Z AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 2681 EP - 2690 VL - 66 IS - 6 SN - 8750-7587, 8750-7587 KW - Methacrylates KW - 0 KW - Platelet Activating Factor KW - Prostaglandin Endoperoxides, Synthetic KW - Thromboxane A2 KW - 57576-52-0 KW - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid KW - 76898-47-0 KW - Thromboxane-A Synthase KW - EC 5.3.99.5 KW - ozagrel KW - L256JB984D KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Swine KW - Animals KW - Prostaglandin Endoperoxides, Synthetic -- pharmacology KW - Thromboxane-A Synthase -- antagonists & inhibitors KW - Methacrylates -- pharmacology KW - Male KW - Female KW - Indomethacin -- pharmacology KW - Hypotension -- chemically induced KW - Platelet Activating Factor -- pharmacology KW - Thromboxane A2 -- pharmacology KW - Hypotension -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79076845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Mechanisms+of+hypotension+produced+by+platelet-activating+factor.&rft.au=Laurindo%2C+F+R%3BGoldstein%2C+R+E%3BDavenport%2C+N+J%3BEzra%2C+D%3BFeuerstein%2C+G+Z&rft.aulast=Laurindo&rft.aufirst=F&rft.date=1989-06-01&rft.volume=66&rft.issue=6&rft.spage=2681&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-22 N1 - Date created - 1989-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Human and animal bite infections. AN - 79015180; 2656906 AB - Although often innocuous initially, human and animal bites can cause serious local and systemic infections as well as other complications. Bites to a site where joints or bones are close to the skin are especially prone to severe complications. Bites to the hand, therefore, require meticulous radiographic and surgical evaluation if a puncture or a severe laceration has occurred. Since the normal human oral flora harbors more pathogens than that of animals, human bites have a higher incidence of serious infections and complications. The oral flora of both humans and animals is anaerobic-aerobic, and initial empiric treatment requires the most broad spectrum antimicrobial therapy available, in addition to scrupulous wound management and, when required, immunization against rabies and tetanus. JF - The Journal of family practice AU - Brook, I AD - Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 713 EP - 718 VL - 28 IS - 6 SN - 0094-3509, 0094-3509 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Bacterial Infections -- microbiology KW - Humans KW - Cats KW - Dogs KW - Animals, Domestic KW - Wound Infection -- microbiology KW - Bites, Human -- complications KW - Bites and Stings -- complications KW - Bites, Human -- microbiology KW - Bites and Stings -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79015180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+family+practice&rft.atitle=Human+and+animal+bite+infections.&rft.au=Brook%2C+I&rft.aulast=Brook&rft.aufirst=I&rft.date=1989-06-01&rft.volume=28&rft.issue=6&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+family+practice&rft.issn=00943509&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-11 N1 - Date created - 1989-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Oral contraceptive use in women with a family history of breast cancer. AN - 78996891; 2726118 AB - To evaluate the effect of oral contraceptive use on the risk of breast cancer from 20-54 years of age in women with a family history of the disease, we analyzed data from the Cancer and Steroid Hormone Study of the Centers for Disease Control and the National Institute of Child Health and Human Development. For 2 years, beginning December 1980, the study enrolled from eight geographical areas in the United States 4730 women with breast cancer and 4646 controls who were breast cancer-free. For women with a first-degree family history of breast cancer, 554 cases and 280 controls, there was no evidence that use of oral contraceptives, even long-term, contributed to their risk of the disease. Neither total duration of use nor duration of use before first term pregnancy bore any relationship with breast cancer risk. Analyses designed to reveal a potential latent effect also showed no evidence of an adverse effect. For women with a second-degree family history of breast cancer, 777 cases and 595 controls, some isolated elevations in risk were observed for selected subgroups of oral contraceptive users. Detailed analyses of oral contraceptive formulation, the characteristics of the women involved, and the patterns of risk observed by latent period and duration of use suggest that these results, most within the limits of chance variation, are not likely to be a consequence of oral contraception. JF - Obstetrics and gynecology AU - Murray, P P AU - Stadel, B V AU - Schlesselman, J J AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 977 EP - 983 VL - 73 IS - 6 SN - 0029-7844, 0029-7844 KW - Contraceptives, Oral KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Epidemiologic Methods KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Time Factors KW - Female KW - Pregnancy KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78996891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Oral+contraceptive+use+in+women+with+a+family+history+of+breast+cancer.&rft.au=Murray%2C+P+P%3BStadel%2C+B+V%3BSchlesselman%2C+J+J&rft.aulast=Murray&rft.aufirst=P&rft.date=1989-06-01&rft.volume=73&rft.issue=6&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-28 N1 - Date created - 1989-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Diagnostic and operative arthroscopy of the knee under local anesthesia with parenteral medication AN - 20078329; 10093296 AB - Arthroscopy of the knee under local anesthesia was performed on 102 patients for operative and diagnostic purposes between January and December of 1985. The procedures were performed on a same day basis without a pneumatic tourniquet. The operative record of each patient was reviewed to determine postopera tive diagnosis and treatment. The data was matched to a patient questionnaire that measured individual reaction to local anesthesia. The effectiveness and level of patient acceptance of this anesthetic technique for operative arthroscopy was then evaluated.Ninety-one patients responded to the questionnaire, 82 of whom had prior anesthetic experience. Ninety- five percent of the patients had minimal or no discomfort during the procedure. Eighty percent indicated a pref erence for local anesthesia in the event of subsequent arthroscopy. No complications relating to the anesthetic agent were noted.Arthroscopy of the knee under local anesthesia for routine operative arthroscopy was found to be safe, reliable, practical, and to have a high patient acceptance rate. JF - American Journal of Sports Medicine AU - Martin, Robert C AU - Brown, David E AU - Zell, Brian K AU - Lichtman, David M AD - Division of Sports Medicine, Department of Orthopaedic Surgery, Naval Hospital, and the Department of Surgery, F. Edward Hebert SOM, Uniformed Services University of the Health Sciences, Bethesda, Maryland Y1 - 1989/06// PY - 1989 DA - Jun 1989 SP - 436 EP - 439 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 17 IS - 3 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Evaluation KW - Anesthesia KW - Surgery KW - Knees KW - Recruiting KW - Surveys KW - Techniques KW - Patients KW - Sports medicine KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20078329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Diagnostic+and+operative+arthroscopy+of+the+knee+under+local+anesthesia+with+parenteral+medication&rft.au=Martin%2C+Robert+C%3BBrown%2C+David+E%3BZell%2C+Brian+K%3BLichtman%2C+David+M&rft.aulast=Martin&rft.aufirst=Robert&rft.date=1989-06-01&rft.volume=17&rft.issue=3&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658901700320 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Evaluation; Anesthesia; Surgery; Recruiting; Knees; Techniques; Surveys; Patients; Sports medicine DO - http://dx.doi.org/10.1177/036354658901700320 ER - TY - JOUR T1 - Microbiology of wound infection after head and neck cancer surgery. AN - 85182369; pmid-2785783 AB - Specimens of pus were obtained from 24 patients who developed postoperative wound infection after head and neck cancer surgery. Aerobic bacteria only were isolated in two instances (8%), anaerobic bacteria only in one (4%), and mixed aerobic and anaerobic bacteria in 21 (88%). A total of 146 isolates were recovered (66 aerobic and 80 anaerobic), an average of six isolates per specimen (2.7 aerobic and 3.3 anaerobic). The most frequently recovered isolates were Peptostreptococcus sp, Staphylococcus aureus, Bacteroides sp, Fusobacterium, and enteric gram-negative rods. Twenty-two isolates recovered from 17 wounds (71%) produced beta-lactamase. These included all five isolates of S aureus and nine of 17 (53%) of the Bacteroides melaninogenicus group. The polymicrobial aerobic/anaerobic nature of postoperative wound infections after head and neck cancer surgery and the presence of beta-lactamase-producing bacteria may have important implications for the management of these infections. JF - The Annals of Otology, Rhinology, and Laryngology AU - Brook, I AU - Hirokawa, R AD - Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland. PY - 1989 SP - 323 EP - 325 VL - 98 IS - 5 Pt 1 SN - 0003-4894, 0003-4894 KW - Bacterial Infections KW - Bacteria, Anaerobic KW - Humans KW - Aged KW - Surgical Wound Infection KW - beta-Lactamases KW - Head and Neck Neoplasms KW - Adult KW - Suppuration KW - Middle Aged KW - Bacteria, Aerobic KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85182369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Microbiology+of+wound+infection+after+head+and+neck+cancer+surgery.&rft.au=Brook%2C+I%3BHirokawa%2C+R&rft.aulast=Brook&rft.aufirst=I&rft.date=1989-05-01&rft.volume=98&rft.issue=5+Pt+1&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Evaluations of permethrin-impregnated clothing and three topical repellent formulations of deet against tsetse flies in Zambia. AN - 79588175; 2519659 AB - Permethrin-impregnated clothing and three topical repellent formulations of deet (diethyltoluamide) were field tested against natural populations of tsetse flies, mostly Glossina morsitans centralis Machado, in central Zambia. Volunteers wore different combinations of clothing impregnated with permethrin 0.125 mg ai/cm2 and repellents while riding in a vehicle that was driven slowly (4-6 km/h), with the windows and rear door open, through fly-infested areas. The mean rate of tsetse bites was about twenty per 75 min for unprotected people. The treatment combination of permethrin-impregnated clothing (blue cotton coveralls) and either of two controlled-release deet formulations on exposed skin of face and arms provided 91% mean protection, but this was not significantly better (P greater than 0.05) than wearing deet repellent alone (76-87% protection). No significant differences of protection were observed between the three repellent treatments, although the two controlled-release formulations (intended to be more persistent) were applied at approximately half the dosage of the standard 75% deet. Wearing permethrin-impregnated coveralls alone provided relatively poor protection (34%) for the untreated and exposed skin of head and hands. However, olive drab mesh jackets treated with permethrin reduced the tsetse biting rate by 75%. JF - Medical and veterinary entomology AU - Sholdt, L L AU - Schreck, C E AU - Mwangelwa, M I AU - Nondo, J AU - Siachinji, V J AD - Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 153 EP - 158 VL - 3 IS - 2 SN - 0269-283X, 0269-283X KW - Insect Repellents KW - 0 KW - Insecticides KW - Pyrethrins KW - DEET KW - 134-62-3 KW - Permethrin KW - 509F88P9SZ KW - Index Medicus KW - Animals KW - Zambia KW - Protective Clothing KW - Humans KW - Insect Bites and Stings -- prevention & control KW - Male KW - Female KW - Tsetse Flies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79588175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+and+veterinary+entomology&rft.atitle=Evaluations+of+permethrin-impregnated+clothing+and+three+topical+repellent+formulations+of+deet+against+tsetse+flies+in+Zambia.&rft.au=Sholdt%2C+L+L%3BSchreck%2C+C+E%3BMwangelwa%2C+M+I%3BNondo%2C+J%3BSiachinji%2C+V+J&rft.aulast=Sholdt&rft.aufirst=L&rft.date=1989-04-01&rft.volume=3&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Medical+and+veterinary+entomology&rft.issn=0269283X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-12 N1 - Date created - 1992-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Alcoholism in the workplace. AN - 79004008; 2658146 JF - Occupational medicine (Philadelphia, Pa.) AU - Harig, P T AD - School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland. PY - 1989 SP - 213 EP - 221 VL - 4 IS - 2 SN - 0885-114X, 0885-114X KW - Index Medicus KW - Risk Factors KW - Humans KW - Alcoholism -- rehabilitation KW - Alcoholism -- etiology KW - Attitude to Health KW - Alcoholism -- diagnosis KW - Occupational Health Services -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79004008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.atitle=Alcoholism+in+the+workplace.&rft.au=Harig%2C+P+T&rft.aulast=Harig&rft.aufirst=P&rft.date=1989-04-01&rft.volume=4&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Occupational+medicine+%28Philadelphia%2C+Pa.%29&rft.issn=0885114X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-07-03 N1 - Date created - 1989-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Transient hypertension after two phenylpropanolamine diet aids and the effects of caffeine: a placebo-controlled follow-up study. AN - 78896915; 2929629 AB - Reports of severe adverse reactions following the ingestion of single (75 mg) or double doses of the sympathomimetic drug phenylpropanolamine (PPA), with and without caffeine, prompted us to undertake a study of the effects of five drug preparations (75 mg PPA, 150 mg PPA, 75 mg PPA plus 400 mg caffeine, 400 mg caffeine, and placebo) in 16 resting, normotensive subjects. The study was of a double-blind, randomized, crossover design. Each subject consented to take the five drug preparations on different study days, which were separated by at least 48 hours. Compared with blood pressure (BP) values obtained after placebo ingestion, significant BP increases occurred over several hours following 150 mg PPA and after 75 mg PPA plus 400 mg caffeine. Significant BP increases after ingestion of 75 mg PPA and after 400 mg caffeine were less frequent. The mean peak BP following 150 mg PPA was 173 +/- 9/103 +/- 4 mm Hg, compared with 148 +/- 4/97 +/- 3 mm Hg after the other three active preparations; after placebo, peak BP reached 137 +/- 8/85 +/- 5 mm Hg. These results indicate that 150 mg PPA (the amount in two diet aids) substantially elevates BP. Our findings may explain some of the recent case reports of nontraumatic intracranial hemorrhage in young, healthy persons ingesting PPA at recommended or minimally greater dosages. We suggest physicians inform patients who are likely consumers of PPA (i.e., those with allergies, those with eating disorders, overweight persons, women during the postpartum period) and patients at risk for stroke (i.e., the elderly and hypertensive patients) of the risks of taking more than the recommended amounts of PPA and of combining caffeine with PPA. JF - The American journal of medicine AU - Lake, C R AU - Zaloga, G AU - Bray, J AU - Rosenberg, D AU - Chernow, B AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland 20814-4799. Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 427 EP - 432 VL - 86 IS - 4 SN - 0002-9343, 0002-9343 KW - Placebos KW - 0 KW - Phenylpropanolamine KW - 33RU150WUN KW - Caffeine KW - 3G6A5W338E KW - Abridged Index Medicus KW - Index Medicus KW - Heart Rate KW - Drug Interactions KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Electrocardiography KW - Adult KW - Follow-Up Studies KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Phenylpropanolamine -- adverse effects KW - Hypertension -- chemically induced KW - Caffeine -- administration & dosage KW - Caffeine -- adverse effects KW - Phenylpropanolamine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78896915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Transient+hypertension+after+two+phenylpropanolamine+diet+aids+and+the+effects+of+caffeine%3A+a+placebo-controlled+follow-up+study.&rft.au=Lake%2C+C+R%3BZaloga%2C+G%3BBray%2C+J%3BRosenberg%2C+D%3BChernow%2C+B&rft.aulast=Lake&rft.aufirst=C&rft.date=1989-04-01&rft.volume=86&rft.issue=4&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-02 N1 - Date created - 1989-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Military Keynesianism in the Third World: An Assessment of Non-Military Motivations for Arms Production AN - 61019835; 90V9883 AB - A modernization perspective is taken to examine the strengths & implications of using a military Keynesianism model (combining elements of classical, Marxist, & Keynesian models) for researching the economic effects of military production & expenses in less developed countries (LDCs). A review of recent literature establishes that Third World countries increased their defense spending by 50% between 1975 & 1985, in comparison to the general worldwide increase of 30%, & that many of these produce their own arms. Both favorable & unfavorable economic consequences of military spending in LDCs are examined, in terms of the impact on consumption, investment, production, industrial output, & inflation. It is concluded that for Third World arms producers, an increase in military spending generally results in economic growth, while an increase in the military budget for nonproducers usually induces slower economic growth. 1 Table, 53 References. E. Swank JF - Journal of Political and Military Sociology AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1989/04// PY - 1989 DA - April 1989 SP - 43 EP - 64 VL - 17 IS - 1 SN - 0047-2697, 0047-2697 KW - military production/expenses, less developed countries, economic effects KW - literature review KW - Military Sociology KW - Keynesian Economics KW - Defense Spending KW - Armaments KW - Economic Development KW - Developing Countries KW - article KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61019835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Political+and+Military+Sociology&rft.atitle=Military+Keynesianism+in+the+Third+World%3A+An+Assessment+of+Non-Military+Motivations+for+Arms+Production&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1989-04-01&rft.volume=17&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Journal+of+Political+and+Military+Sociology&rft.issn=00472697&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JPMSCG N1 - SubjectsTermNotLitGenreText - Developing Countries; Keynesian Economics; Military Sociology; Defense Spending; Armaments; Economic Development ER - TY - JOUR T1 - Stereoselective formations of enantiomeric K-region epoxide and trans-dihydrodiols in dibenz[a,h]anthracene metabolism. AN - 79587348; 2519714 AB - Metabolism of dibenz[a,h]anthracene (DBA) to optically active epoxide and dihydrodiol products by rat liver microsomes was investigated. Enantiomeric separation of K-region 5,6-epoxide, trans- and cis-5,6-dihydrodiols, non-K-region trans-1,2- and trans-3, 4-dihydrodiols, and O-methyl ethers derived from methoxylation of racemic and enantiomeric K-region 5,6-epoxides was performed on HPLC columns packed with Pirkle chiral stationary-phase (CSP) (R)-N-(3,5-dinitrobenzoyl)phenylglycine (R-DNBPG) or (S)-N-(3,5-dinitrobenzoyl) leucine (S-DNBL), which was either ionically or covalently bonded to a silica gel support. Enantiomers of DBA 5,6-epoxide, trans-5,6-dihydrodiol, and its two isomeric O-methyl ethers were efficiently separated on the ionically bonded R-DNBPG column. Enantiomers of DBA cis-5, 6-dihydrodiol were resolved on both ionically and covalently bonded S-DNBL columns. Enantiomeric pairs of the non-K-region trans-1,2- and 3,4-dihydrodiols were poorly resolved on all CSPs tested. DBA was incubated with a NADPH-regenerating system and liver microsomes from untreated, phenobarbital- (PB) treated, 3-methylcholanthrene- (MC) treated, and polychlorinated biphenyl (PCB, Aroclor 1254) treated rats either in the absence or in the presence of an epoxide hydrolase inhibitor, 3,3,3-trichloropropylene 1,2-oxide (TCPO). Metabolites formed were analyzed by reversed-phase, normal-phase, and CSP HPLC. CD spectral and CSP-HPLC analyses of metabolically formed trans-dihydrodiols indicated that the dihydrodiols are highly enriched in the R,R-enantiomers.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Chemical research in toxicology AU - Mushtaq, M AU - Weems, H B AU - Yang, S K AD - Department of Pharmacology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. PY - 1989 SP - 84 EP - 93 VL - 2 IS - 2 SN - 0893-228X, 0893-228X KW - Benz(a)Anthracenes KW - 0 KW - Epoxy Compounds KW - Phenols KW - Hydrogen KW - 7YNJ3PO35Z KW - Epoxide Hydrolases KW - EC 3.3.2.- KW - 1,2,5,6-dibenzanthracene KW - T30ELH3D5X KW - Index Medicus KW - Animals KW - Epoxide Hydrolases -- metabolism KW - Stereoisomerism KW - Microsomes, Liver -- metabolism KW - Phenols -- metabolism KW - Circular Dichroism KW - Chromatography, High Pressure Liquid KW - Rats, Inbred Strains KW - Rats KW - In Vitro Techniques KW - Phenols -- isolation & purification KW - Hydrogen -- metabolism KW - Molecular Conformation KW - Male KW - Epoxy Compounds -- metabolism KW - Benz(a)Anthracenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79587348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Stereoselective+formations+of+enantiomeric+K-region+epoxide+and+trans-dihydrodiols+in+dibenz%5Ba%2Ch%5Danthracene+metabolism.&rft.au=Mushtaq%2C+M%3BWeems%2C+H+B%3BYang%2C+S+K&rft.aulast=Mushtaq&rft.aufirst=M&rft.date=1989-03-01&rft.volume=2&rft.issue=2&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-02-21 N1 - Date created - 1992-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The pharmacology of cocaine related to its abuse. AN - 79305115; 2682679 JF - Pharmacological reviews AU - Johanson, C E AU - Fischman, M W AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1989/03// PY - 1989 DA - March 1989 SP - 3 EP - 52 VL - 41 IS - 1 SN - 0031-6997, 0031-6997 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Humans KW - Substance-Related Disorders -- physiopathology KW - Substance-Related Disorders -- psychology KW - Cocaine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79305115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+reviews&rft.atitle=The+pharmacology+of+cocaine+related+to+its+abuse.&rft.au=Johanson%2C+C+E%3BFischman%2C+M+W&rft.aulast=Johanson&rft.aufirst=C&rft.date=1989-03-01&rft.volume=41&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Pharmacological+reviews&rft.issn=00316997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-04 N1 - Date created - 1989-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Precipitation in the Canadian Atlantic Storms Program: Measurements of the Acoustic Signature AN - 19090506; 9001215 AB - The Canadian Atlantic Storms Program (CASP) provided an opportunity for comparing two quite different remote-sensing approaches to the detection of precipitation: radar backscatter and ambient ocean sound. Several of the gales passing the observation area during CASP produced substantial precipitation with the periods of radar backscatter showing close coincidence with simultaneous acoustic signals. The ambient sound record most readily yield an indication of precipitation from shifts in spectral slope. An important result of the experiment is the demonstration that an identifiable precipitation signal occurs even in strong wind conditions. The surface bubble layer formed during strong winds only partially attenuates the higher frequency acoustic components generated by precipitation. During rain-free periods the attenuation can be interpreted in terms of the bubble size distribution. (Author 's abstract) JF - Atmosphere-Ocean ATOCDA Vol. 27, No. 1, p 237-257, March 1989. 14 fig, 1 tab, 22 ref. AU - Nystuen, JA AU - Farmer, D M AD - Naval Postgraduate School Monterey, CA. Dept. of Oceanography Y1 - 1989/03// PY - 1989 DA - Mar 1989 KW - Water Resources Abstracts KW - Canada KW - Precipitation KW - Storms KW - Weather KW - Remote sensing KW - Meteorology KW - Radar KW - Weather data collections KW - Meteorological data collection KW - Rainfall KW - Atmospheric water KW - Wind KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19090506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Precipitation+in+the+Canadian+Atlantic+Storms+Program%3A+Measurements+of+the+Acoustic+Signature&rft.au=Nystuen%2C+JA%3BFarmer%2C+D+M&rft.aulast=Nystuen&rft.aufirst=JA&rft.date=1989-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Reduced formation of bipyrimidine photoproducts in DNA UV irradiated at high intensity. AN - 78833887; 2914917 AB - DNA was irradiated using an excimer laser (248 nm) at low intensity (3.15 x 10(7) watts/m2) or high intensity (1.25 x 10(11) watts/m2). Fluences up to 30 kJ/m2 were delivered at either intensity. Following irradiation, DNA damage products were measured, yielding the following findings: 1) the rate of formation of thymine-thymine and thymine-cytosine cyclobutane dimers and the bipyrimidine photoadduct 6-4'-[pyrimidine-2'-one]thymine were reduced at high intensity by about 2-fold and 2) extensive release of free thymine and thymine decomposition fragments occurred at high intensity, but not at low intensity. The effects of high intensity UV are due to promotion of low-lying excited state(s) by absorption of a second photon, producing higher excited state(s) with consequent ionization and base loss. Possible excited state intermediates in this process are the lowest triplet state of DNA bases and prolonged singlet states associated with excimer formation. The depletion of these excited states via promotion may be the cause of the diminished yield of bimolecular pyrimidine photoproducts, suggesting that these photoproducts are formed at low UV intensity in part from long-lived excited states. Long-lived excited states present at conventional UV intensities may contribute to formation of some photoproducts that occur rarely, but are of potential biologic importance, such as dimers between nonadjacent pyrimidines on the same strand and interstrand dimers forming DNA cross-links. JF - The Journal of biological chemistry AU - Masnyk, T W AU - Nguyen, H T AU - Minton, K W AD - Department of Pathology, Uniformed Services University of the Health Sciences, F. Edward Herbert School of Medicine, Bethesda, Maryland 20814-4799. Y1 - 1989/02/15/ PY - 1989 DA - 1989 Feb 15 SP - 2482 EP - 2488 VL - 264 IS - 5 SN - 0021-9258, 0021-9258 KW - Pyrimidine Dimers KW - 0 KW - DNA KW - 9007-49-2 KW - Thymine KW - QR26YLT7LT KW - Index Medicus KW - Thymine -- isolation & purification KW - Photolysis KW - DNA Damage KW - Lasers KW - Dose-Response Relationship, Radiation KW - Thymine -- radiation effects KW - Ultraviolet Rays KW - Pyrimidine Dimers -- isolation & purification KW - DNA -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78833887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Reduced+formation+of+bipyrimidine+photoproducts+in+DNA+UV+irradiated+at+high+intensity.&rft.au=Masnyk%2C+T+W%3BNguyen%2C+H+T%3BMinton%2C+K+W&rft.aulast=Masnyk&rft.aufirst=T&rft.date=1989-02-15&rft.volume=264&rft.issue=5&rft.spage=2482&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-21 N1 - Date created - 1989-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Halocarbon hepatotoxicity is not initiated by Ca2+-stimulated endonuclease activation. AN - 78882167; 2538008 AB - Previous studies from this laboratory have demonstrated that cytosolic Ca2+ rapidly rises to supraphysiologic levels in liver cells exposed to the hepatotoxins carbon tetrachloride (CCl4) and 1,1-dichloroethylene (DCE) in vivo and in vitro. The present study examines whether this increase in intracellular Ca2+ activates endonucleases that could initiate or contribute to the ensuing hepatotoxic events. Initial experiments demonstrated that there was no generalized breakdown of hepatic DNA in intact rats exposed to CCl4 and DCE, as assessed by the appearance of nucleosomal fragments in liver nuclear DNA separated on agarose gels. Nor was generalized fragmentation observed in DNA isolated from primary hepatocyte cultures exposed to halocarbons, except at very late times following loss of plasma membrane integrity. Endonuclease activation was further examined at a more sensitive level by specifically monitoring hypersensitive sites (HSS) in serum albumin gene. Actively transcribed genes, such as albumin in liver tissue, are extremely sensitive to attack by exogenous nucleolytic enzymes at discrete sites. We speculated that subtle halocarbon-induced endonuclease activation would first become evident at these sites. To locate HSS, DNA was digested with restriction enzymes Eco R1 or Hind III, electrophoresed on agarose gels, blotted onto nitrocellulose, and hybridized to a 32P-labeled 1400 bp rat albumin genomic clone. No cleavage at hypersensitive sites was detected in DNA isolated from rat liver or hepatocyte DNA at early times when elevations of Ca2+ were developing. Thus, these data indicate that endonuclease activation by intracellular Ca2+ and resultant nucleolytic destruction of DNA is not an early event in the hepatotoxicity produced by halocarbons. JF - Toxicology and applied pharmacology AU - Long, R M AU - Moore, L AU - Schoenberg, D R AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 350 EP - 359 VL - 97 IS - 2 SN - 0041-008X, 0041-008X KW - Dichloroethylenes KW - 0 KW - Hydrocarbons, Chlorinated KW - DNA KW - 9007-49-2 KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Endonucleases KW - EC 3.1.- KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Enzyme Activation KW - DNA Damage KW - DNA -- metabolism KW - Male KW - Dichloroethylenes -- toxicity KW - Endonucleases -- physiology KW - Hydrocarbons, Chlorinated -- toxicity KW - Liver -- drug effects KW - Calcium -- physiology KW - Carbon Tetrachloride -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78882167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Halocarbon+hepatotoxicity+is+not+initiated+by+Ca2%2B-stimulated+endonuclease+activation.&rft.au=Long%2C+R+M%3BMoore%2C+L%3BSchoenberg%2C+D+R&rft.aulast=Long&rft.aufirst=R&rft.date=1989-02-01&rft.volume=97&rft.issue=2&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-07 N1 - Date created - 1989-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Internal and External Factors in Effecting Third World Military Expenditures AN - 61549777; 199001427 AB - The effects of economic conditions on the level of Third World military expenditures, especially indigenous arms production, are examined based on cross-sectional data for the early 1980s. A review of the economic impact & economic determinants literature provides variables & implications for a mathematical model accounting for all phases of military expenditures, such as arms imports & share of defense expenditures in the government budget, as well as for total imports & external debt. The relative impact of internal (economic) & external (threat) forces on military expenditures is estimated from the model, supporting the hypothesis that military expenditure levels are determined largely by economic constraints. A reduction in Third World arms production may decrease the level of military expenditures, since countries without an arms industry are less affected by economic factors. 53 References. M. Malas JF - Journal of Peace Research AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1989/02// PY - 1989 DA - February 1989 SP - 33 EP - 46 VL - 26 IS - 1 SN - 0022-3433, 0022-3433 KW - military expenditures, Third World, economic conditions KW - cross-sectional data KW - literature review KW - 1980s KW - Economic Factors KW - Defense Spending KW - International Relations KW - Developing Countries KW - article KW - 8309: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61549777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Peace+Research&rft.atitle=Internal+and+External+Factors+in+Effecting+Third+World+Military+Expenditures&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1989-02-01&rft.volume=26&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+Peace+Research&rft.issn=00223433&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Developing Countries; Economic Factors; Defense Spending; International Relations ER - TY - JOUR T1 - Gastrin-releasing peptide (GRP, mammalian bombesin) in the pathogenesis of lung cancer. AN - 79581712; 2491257 AB - Established human lung cancer exhibits a complex pattern of genetic changes as well as several distinct autocrine growth factor loops for regulatory peptides. The best studied example is that of gastrin-releasing peptide (GRP), the mammalian homolog of the amphibian bombesin. It is produced by up to 70% of small cell lung cancers and 10-20% of non-small cell lung cancers. GRP stimulates the growth of normal bronchial epithelium as well as that of small cell lung cancer, and its blockade with the use of antibodies or synthetic antagonists inhibits the growth of these tumors. Study of its molecular biology has revealed a complex pattern of mRNA processing which has lead to the recent isolation of a novel family of peptides termed gastrin-releasing peptide gene-associated peptides (GGAPs), present in normal and malignant human tissues. Additional efforts have been directed at characterizing the GRP receptor as well as its intracellular signaling pathways which have been reported both as G protein phospholipase C coupled events as well as activation of a membrane associated tyrosine kinase. In view of its expression in normal bronchial epithelium and its mitogenic effects on this tissue, GRP appears to play a central role in the early events of pulmonary carcinogenesis. JF - Progress in growth factor research AU - Viallet, J AU - Minna, J D AD - NCI-Navy Medical Oncology Branch, National Cancer Institute and Uniformed Services, University of the Health Sciences, Bethesda, MD 20814. Y1 - 1989 PY - 1989 DA - 1989 SP - 89 EP - 97 VL - 1 IS - 2 SN - 0955-2235, 0955-2235 KW - Peptides KW - 0 KW - Gastrin-Releasing Peptide KW - 80043-53-4 KW - Bombesin KW - PX9AZU7QPK KW - Index Medicus KW - Animals KW - Humans KW - Lung Neoplasms -- etiology KW - Bombesin -- genetics KW - Peptides -- genetics KW - Peptides -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79581712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+growth+factor+research&rft.atitle=Gastrin-releasing+peptide+%28GRP%2C+mammalian+bombesin%29+in+the+pathogenesis+of+lung+cancer.&rft.au=Viallet%2C+J%3BMinna%2C+J+D&rft.aulast=Viallet&rft.aufirst=J&rft.date=1989-01-01&rft.volume=1&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Progress+in+growth+factor+research&rft.issn=09552235&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-01 N1 - Date created - 1991-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Assessing the reinforcing properties of drugs. AN - 79553294; 2701296 JF - NIDA research monograph AU - Johanson, C E AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1989 PY - 1989 DA - 1989 SP - 135 EP - 145 VL - 95 SN - 1046-9516, 1046-9516 KW - Psychotropic Drugs KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Reinforcement (Psychology) KW - Self Administration -- psychology KW - Drug Evaluation, Preclinical KW - Substance-Related Disorders -- psychology KW - Psychotropic Drugs -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79553294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Assessing+the+reinforcing+properties+of+drugs.&rft.au=Johanson%2C+C+E&rft.aulast=Johanson&rft.aufirst=C&rft.date=1989-01-01&rft.volume=95&rft.issue=&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-20 N1 - Date created - 1990-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Smoking. AN - 79524782; 2637864 JF - Health psychology : official journal of the Division of Health Psychology, American Psychological Association AU - Grunberg, N E AU - Evans, R I AU - Curry, S AU - DiClemente, C AU - Epstein, L H AU - Horton, A M AU - Lichtenstein, E AU - McCaul, K AU - Perkins, K AU - Wallston, K A AD - Department of Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1989 PY - 1989 DA - 1989 SP - 767 EP - 771 VL - 8 IS - 6 SN - 0278-6133, 0278-6133 KW - Index Medicus KW - Humans KW - Forecasting KW - Research -- trends KW - Tobacco Use Disorder -- therapy KW - Tobacco Use Disorder -- psychology KW - Tobacco Use Disorder -- prevention & control KW - Smoking -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79524782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+psychology+%3A+official+journal+of+the+Division+of+Health+Psychology%2C+American+Psychological+Association&rft.atitle=Smoking.&rft.au=Grunberg%2C+N+E%3BEvans%2C+R+I%3BCurry%2C+S%3BDiClemente%2C+C%3BEpstein%2C+L+H%3BHorton%2C+A+M%3BLichtenstein%2C+E%3BMcCaul%2C+K%3BPerkins%2C+K%3BWallston%2C+K+A&rft.aulast=Grunberg&rft.aufirst=N&rft.date=1989-01-01&rft.volume=8&rft.issue=6&rft.spage=767&rft.isbn=&rft.btitle=&rft.title=Health+psychology+%3A+official+journal+of+the+Division+of+Health+Psychology%2C+American+Psychological+Association&rft.issn=02786133&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-26 N1 - Date created - 1990-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cardiovascular reactivity, mood, and task performance in deprived and nondeprived coffee drinkers. AN - 79332963; 2583079 AB - Forty habitual, heavy coffee drinkers (M = 5.7 cups/day) participated in two experimental sessions. Participants were deprived of their morning coffee for one of the laboratory sessions, not deprived the other. During each session, subjects consumed 12 oz of caffeinated coffee, decaffeinated coffee, or caffeine-free herbal tea. Measurements of heart rate, blood pressure, mood, and catecholamine response to deprivation and consumption of the beverage, alone and in combination with challenging tasks, were made. This study found that caffeine continues to cause blood pressure increases with chronic, heavy consumption and that these effects do not appear to habituate with regular use. Subjects reacted to behavioral challenge with fewer negative mood effects if they had consumed caffeine or coffee. Mild caffeine deprivation was associated with symptoms of stress. JF - Health psychology : official journal of the Division of Health Psychology, American Psychological Association AU - Ratliff-Crain, J AU - O'Keeffe, M K AU - Baum, A AD - Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1989 PY - 1989 DA - 1989 SP - 427 EP - 447 VL - 8 IS - 4 SN - 0278-6133, 0278-6133 KW - Coffee KW - 0 KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Pattern Recognition, Visual -- drug effects KW - Discrimination Learning -- drug effects KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Problem Solving -- drug effects KW - Color Perception -- drug effects KW - Male KW - Female KW - Affect -- drug effects KW - Arousal -- drug effects KW - Caffeine -- adverse effects KW - Coffee -- adverse effects KW - Substance Withdrawal Syndrome -- psychology KW - Attention -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79332963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+psychology+%3A+official+journal+of+the+Division+of+Health+Psychology%2C+American+Psychological+Association&rft.atitle=Cardiovascular+reactivity%2C+mood%2C+and+task+performance+in+deprived+and+nondeprived+coffee+drinkers.&rft.au=Ratliff-Crain%2C+J%3BO%27Keeffe%2C+M+K%3BBaum%2C+A&rft.aulast=Ratliff-Crain&rft.aufirst=J&rft.date=1989-01-01&rft.volume=8&rft.issue=4&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Health+psychology+%3A+official+journal+of+the+Division+of+Health+Psychology%2C+American+Psychological+Association&rft.issn=02786133&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-28 N1 - Date created - 1989-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Neuroendocrine responses to nicotine and stress: enhancement of peripheral stress responses by the administration of nicotine. AN - 79200873; 2505296 AB - Habitual smokers frequently report that when they are stressed smoking helps them to relax. One potential explanation for the reported stress ameliorating effect of smoking is that cigarette consumption (nicotine self-administration) may decrease the sympathetic autonomic nervous system activity which is associated with the stress response. In the present study, rabbits prepared with chronic vascular cannulae were used to study the effects of nicotine administration on plasma corticosterone, catecholamine (epinephrine, norepinephrine and dopamine) and glucose responses to physical restraint stress. Nicotine (0.025, 0.05 or 0.10 mg nicotine base/kg body weight) was administered for 10 days prior to the "stress test" to allow for the development of habituation/tolerance to its acute toxic effects. Independent administration of nicotine, or the application of the physical restraint stressor, resulted in increases in the plasma concentrations of corticosterone, epinephrine, norepinephrine, and glucose. Nicotine administration during restraint stress enhanced the increase in plasma corticosterone and epinephrine, as compared to the responses induced by either factor alone. The results suggest that the stress ameliorating effect of continued cigarette smoking, as reported by habitual smokers, is not due to a reduction in the activity of the peripheral sympathetic autonomic nervous system. JF - Psychopharmacology AU - Morse, D E AD - Department of Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1989 PY - 1989 DA - 1989 SP - 539 EP - 543 VL - 98 IS - 4 SN - 0033-3158, 0033-3158 KW - Blood Glucose KW - 0 KW - Catecholamines KW - Nicotine KW - 6M3C89ZY6R KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Animals KW - Catecholamines -- blood KW - Blood Glucose -- metabolism KW - Corticosterone -- blood KW - Rabbits KW - Male KW - Stress, Psychological -- physiopathology KW - Nicotine -- pharmacology KW - Neurosecretory Systems -- drug effects KW - Nicotine -- blood KW - Neurosecretory Systems -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79200873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Neuroendocrine+responses+to+nicotine+and+stress%3A+enhancement+of+peripheral+stress+responses+by+the+administration+of+nicotine.&rft.au=Morse%2C+D+E&rft.aulast=Morse&rft.aufirst=D&rft.date=1989-01-01&rft.volume=98&rft.issue=4&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-29 N1 - Date created - 1989-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Psychiatric responses to trauma. AN - 78851153; 2643553 AB - Controlled studies examining the relationship between psychiatric disorders and war and other traumatic events are reviewed. Several studies have found a correlation between the severity of posttraumatic stress disorder symptoms and the degree of trauma. Other disorders associated with trauma include depression, substance abuse disorders, adjustment disorders, psychosomatic disorders, and antisocial behavior. No relationship has been found between trauma and subsequent violent behavior. The authors identify areas for further research, including examination of why the majority of persons exposed to trauma do not develop psychiatric illness. JF - Hospital & community psychiatry AU - Rundell, J R AU - Ursano, R J AU - Holloway, H C AU - Silberman, E K AD - Department of psychiatry, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 68 EP - 74 VL - 40 IS - 1 SN - 0022-1597, 0022-1597 KW - Index Medicus KW - Stress Disorders, Post-Traumatic -- etiology KW - Depressive Disorder -- etiology KW - Humans KW - Substance-Related Disorders -- etiology KW - Violence KW - Male KW - Life Change Events KW - Mental Disorders -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78851153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hospital+%26+community+psychiatry&rft.atitle=Psychiatric+responses+to+trauma.&rft.au=Rundell%2C+J+R%3BUrsano%2C+R+J%3BHolloway%2C+H+C%3BSilberman%2C+E+K&rft.aulast=Rundell&rft.aufirst=J&rft.date=1989-01-01&rft.volume=40&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Hospital+%26+community+psychiatry&rft.issn=00221597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-03-01 N1 - Date created - 1989-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Economic Impact of Rent Seeking and Military Expenditures: A Comparison of Third World Military and Civilian Regimes AN - 60963007; 89U5929 AB - The general stereotype of modern Third World military regimes is that of ultra-conservatism combined with military force to dismantle organizations of popular expression. It has been assumed that, through their rent-seeking activities, these organizations have reduced overall rates of economic growth. Though some empirical support for this line of argument is found, using 1981 statistics from the World Bank & the US Arms Control & Disarmament Agency, it is apparent that the traditional stereotypes are inappropriate. The two regime types differ largely in terms of contrasting styles of economic management. Military regimes create an environment where military expenditures tend to have a positive overall impact on economic growth. Civilian regimes, having less control over rent-seeking groups, do not appear to be able to combine rent-seeking activities & military expenditures in a manner conducive to overall economic growth. 6 Tables. Modified HA JF - The American Journal of Economics and Sociology AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 11 EP - 29 VL - 48 IS - 1 SN - 0002-9246, 0002-9246 KW - economic growth impacts, military vs civilian regimes, Third World KW - World Bank/US government statistics KW - Political Systems KW - Economic Development KW - Developing Countries KW - Military Regimes KW - article KW - 0715: social change and economic development; social change & economic development KW - 0925: political sociology/interactions; voting, parties, political systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60963007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Economics+and+Sociology&rft.atitle=The+Economic+Impact+of+Rent+Seeking+and+Military+Expenditures%3A+A+Comparison+of+Third+World+Military+and+Civilian+Regimes&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1989-01-01&rft.volume=48&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Economics+and+Sociology&rft.issn=00029246&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJESA3 N1 - SubjectsTermNotLitGenreText - Developing Countries; Economic Development; Military Regimes; Political Systems ER - TY - JOUR T1 - Arms Races in the Third World: Argentina and Brazil AN - 1761720210; 199000804 AB - An examination of whether a significant part of Argentina's military budget over 1961-1982 can be attributed to an arms race with Brazil. Multiple regression equations are estimated, taking into account Brazil's military spending, changes in political regimes in Argentina, & the availability of economic resources allocated to the government. Results indicate that the arms rivalry existed until the mid-1970s. As a result of increased economic cooperation beween the two countries since then, the arms race has gradually diminished, & other factors have become more important in determining defense spending levels in Argentina. 1 Table. HA JF - Armed Forces and Society AU - Frederiksen, Peter C AU - Looney, Robert E AD - Defense Resources Management Education Center US Naval Postgraduate School, Monterey CA 93940 Y1 - 1989/01// PY - 1989 DA - January 1989 SP - 263 EP - 270 VL - 15 IS - 2 SN - 0095-327X, 0095-327X KW - military budget, Argentina KW - Brazilian arms race KW - 1961-1982 KW - Defense Spending KW - Argentina KW - Armaments KW - International Relations KW - article KW - 8309: international issues in social work UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761720210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Armed+Forces+and+Society&rft.atitle=Arms+Races+in+the+Third+World%3A+Argentina+and+Brazil&rft.au=Frederiksen%2C+Peter+C%3BLooney%2C+Robert+E&rft.aulast=Frederiksen&rft.aufirst=Peter&rft.date=1989-01-01&rft.volume=15&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Armed+Forces+and+Society&rft.issn=0095327X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Argentina; Armaments; International Relations; Defense Spending ER - TY - JOUR T1 - Lethal ischemia due to intracoronary endothelin in pigs. AN - 15840773; 2435166 AB - Endothelin is a recently discovered endothelium-derived peptide with potent coronary constrictor properties in vitro. To evaluate endothelin's cardiac actions in vivo, we measured coronary flow and regional myocardial shortening when intracoronary porcine endothelin was given to anesthetized open-chested pigs. Unlike intracoronary delivery of other potent coronary constrictors, intracoronary administration of endothelin did not lead to rapid escape from the peptide's deleterious influence. Coronary exposure to endothelin under pathophysiological circumstances could result in uniquely persistent decrements in myocardial perfusion and contractile function. JF - American Journal of Physiology AU - Ezra, D AU - Goldstein, R E AU - Czaja, J F AU - Feuerstein, G Z AD - Rm. A-3060, USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA Y1 - 1989 PY - 1989 DA - 1989 SP - H339 EP - H343 VL - 257 IS - 1 SN - 0363-6143, 0363-6143 KW - endothelin KW - pigs KW - Toxicology Abstracts KW - ischemia KW - X 24240:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15840773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology&rft.atitle=Lethal+ischemia+due+to+intracoronary+endothelin+in+pigs.&rft.au=Ezra%2C+D%3BGoldstein%2C+R+E%3BCzaja%2C+J+F%3BFeuerstein%2C+G+Z&rft.aulast=Ezra&rft.aufirst=D&rft.date=1989-01-01&rft.volume=257&rft.issue=1&rft.spage=H339&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology&rft.issn=03636143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - ischemia ER - TY - JOUR T1 - Orthopedic history and examination in the etiology of overuse injuries. AN - 15804913; 2414504 AB - Overuse injuries, and stress fractures in particular, afflict many runners and military recruits. This investigation sought to identify pretraining factors which may predispose to overuse injuries. Orthopedic and running history questionnaires and an orthopedic examination were administered to 505 trainees entering an intensive military training school. A novel method for evaluating ankle dorsiflexion was developed, and alignment measures, in units of centimeters rather than degrees, were obtained. Over 10% of the trainees were removed from the school for overuse-related injuries, and over half of these were tibial stress fractures. The incidence of clinically diagnosed stress fractures was 6.3%. No single orthopedic history question or combination of questions could discriminate between trainees who did or did not subsequently incur overuse injuries. JF - Medicine & Science in Sports & Exercise AU - Montgomery, L C AU - Nelson, FRT AU - Norton, J P AU - Deuster, P A AD - USUHS-MIM, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 237 EP - 243 VL - 21 IS - 3 SN - 0195-9131, 0195-9131 KW - aetiology KW - running KW - fracture KW - sports medicine KW - Health & Safety Science Abstracts KW - stress KW - H SM9.29:BONE INJURIES KW - H SM9.45:SPORTS RELATED INJURIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15804913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine+%26+Science+in+Sports+%26+Exercise&rft.atitle=Orthopedic+history+and+examination+in+the+etiology+of+overuse+injuries.&rft.au=Montgomery%2C+L+C%3BNelson%2C+FRT%3BNorton%2C+J+P%3BDeuster%2C+P+A&rft.aulast=Montgomery&rft.aufirst=L&rft.date=1989-01-01&rft.volume=21&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Medicine+%26+Science+in+Sports+%26+Exercise&rft.issn=01959131&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - stress ER - TY - JOUR T1 - Enzyme-linked immunosorbent assays (ELISA) for the diagnosis of enteric fever. AN - 15563475; 2223750 AB - Serum samples from 10 patients with culture positive Salmonella typhi infection, 30 febrile non-typhoidal patients, and 22 healthy subjects were tested for both Salmonella common structural antigen (CSA) and antibody to pathogenic species of Salmonella . Serum, urine and stool specimens from these patients were used to detect Salmonella antigen(s). Antigen detection in urine was less sensitive and specific compared with assays of stool and blood. The study provides good evidence that ELISA for detection of Salmonella CSA and antibody can aid in the diagnosis and confirmation of infections caused by Salmonella . JF - Tropical and Geographical Medicine AU - Heiba, I AU - Girgis, NI AU - Farid, Z AD - Dep. Prev. Med./Biom., Div. Trop. Public Health, USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA Y1 - 1989 PY - 1989 DA - 1989 SP - 213 EP - 217 VL - 41 IS - 3 KW - Salmonella typhi KW - infection KW - diagnosis KW - Egypt KW - Microbiology Abstracts B: Bacteriology KW - typhoid fever KW - serological tests KW - enzyme-linked immunosorbent assay KW - J 02831:Techniques and reagents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15563475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tropical+and+Geographical+Medicine&rft.atitle=Enzyme-linked+immunosorbent+assays+%28ELISA%29+for+the+diagnosis+of+enteric+fever.&rft.au=Heiba%2C+I%3BGirgis%2C+NI%3BFarid%2C+Z&rft.aulast=Heiba&rft.aufirst=I&rft.date=1989-01-01&rft.volume=41&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Tropical+and+Geographical+Medicine&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - enzyme-linked immunosorbent assay; serological tests; typhoid fever ER - TY - JOUR T1 - Effects of histamine and its receptor antagonists on peritoneal permeability. AN - 78601653; 3210539 AB - Peritoneal fluid and mass transfer rates were studied in rabbits undergoing control dialyses and dialyses with intraperitoneal histamine, or its receptor antagonists alone or in combination. These drugs had negligible effects on peritoneal ultrafiltration and small solute clearances. Histamine raised protein exudation from 1.6 to 2.9 mg/kg/min, an effect blocked by its antagonists which given alone did not lower protein loss. These data demonstrate the existence of histamine receptors in the peritoneal diffusion barrier and show that they do not control transport under baseline conditions, but can be blocked should abnormal histamine release occur. Increased peritoneal permeability with sterile peritonitis was unaffected by ranitidine, suggesting alternative mediators. JF - Kidney international AU - Shostak, A AU - Chakrabarti, E AU - Hirszel, P AU - Maher, J F AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 786 EP - 790 VL - 34 IS - 6 SN - 0085-2538, 0085-2538 KW - Histamine Antagonists KW - 0 KW - Receptors, Histamine KW - Deoxycholic Acid KW - 005990WHZZ KW - Histamine KW - 820484N8I3 KW - Index Medicus KW - Ultrafiltration KW - Animals KW - Receptors, Histamine -- metabolism KW - Rabbits KW - Peritonitis -- chemically induced KW - Capillary Permeability -- drug effects KW - Peritonitis -- metabolism KW - Deoxycholic Acid -- toxicity KW - Female KW - Histamine Antagonists -- pharmacology KW - Histamine -- pharmacology KW - Peritoneum -- metabolism KW - Peritoneal Dialysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78601653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Effects+of+histamine+and+its+receptor+antagonists+on+peritoneal+permeability.&rft.au=Shostak%2C+A%3BChakrabarti%2C+E%3BHirszel%2C+P%3BMaher%2C+J+F&rft.aulast=Shostak&rft.aufirst=A&rft.date=1988-12-01&rft.volume=34&rft.issue=6&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-16 N1 - Date created - 1989-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Effect of ionizing radiation on the gastrointestinal tract. AN - 78704429; 2976384 JF - Fundamental and applied toxicology : official journal of the Society of Toxicology AU - Dubois, A AD - Uniformed Services University of the Health Sciences. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 574 EP - 575 VL - 11 IS - 4 SN - 0272-0590, 0272-0590 KW - Prostaglandins KW - 0 KW - beta-Endorphin KW - 60617-12-1 KW - Index Medicus KW - Animals KW - Vomiting -- prevention & control KW - beta-Endorphin -- metabolism KW - Vomiting -- metabolism KW - Dogs KW - Vomiting -- etiology KW - Macaca mulatta KW - Prostaglandins -- metabolism KW - Radiation Injuries, Experimental -- metabolism KW - Digestive System -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78704429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.atitle=Effect+of+ionizing+radiation+on+the+gastrointestinal+tract.&rft.au=Dubois%2C+A&rft.aulast=Dubois&rft.aufirst=A&rft.date=1988-11-01&rft.volume=11&rft.issue=4&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+applied+toxicology+%3A+official+journal+of+the+Society+of+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-17 N1 - Date created - 1989-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Granulocyte-macrophage colony stimulating factor (GM-CSF) and macrophage colony stimulating factor (CSF-1) synergize to stimulate progenitor cells with high proliferative potential. AN - 78511548; 3053953 AB - The ability to expand a population of bone marrow progenitors capable of forming macrophage colonies of high proliferative potential (HPP-CFC) was achieved using a culture system and signal requirements not previously shown to support the growth of HPP-CFC. Using bone marrow cells from untreated animals (not 5-FU-treated), culture conditions designed primarily for the detection of GM-CFC or M-CFC progenitors, and a more stringent criteria for HPP-CFC colony size (greater than or equal to 2 mm diameter), HPP-CFC progenitor expansion was demonstrated following simultaneous addition of rGM-CSF and CSF-1 to bone marrow cultures. Examination of the sequence and temporal requirements for rGM-CSF and CSF-1 addition necessary for the development of HPP-CFC-like colonies revealed that addition of the second factor could be delayed for up to 5 days and still result in the development of significant numbers of HPP-CFC colonies. Based on a comparison with human spleen cell conditioned medium (HSCM) and interleukin 1 (rIL 1), as sources of "synergistic activity" (SA) for the development of HPP-CFC-like colonies in combination with CSF-1, the combination of GM-CSF and CSF-1 appears to represent a novel pathway for stimulating the expansion of HPP-CFC progenitors with high proliferative potential. JF - Journal of leukocyte biology AU - Falk, L A AU - Vogel, S N AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 455 EP - 464 VL - 44 IS - 5 SN - 0741-5400, 0741-5400 KW - Colony-Stimulating Factors KW - 0 KW - Growth Substances KW - Recombinant Proteins KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Animals KW - Recombinant Proteins -- pharmacology KW - Spleen -- physiology KW - Humans KW - Mice, Inbred C3H KW - Cell Division -- drug effects KW - Fluorouracil -- pharmacology KW - Mice KW - Drug Synergism KW - Growth Substances -- pharmacology KW - Colony-Stimulating Factors -- pharmacology KW - Hematopoietic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78511548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Granulocyte-macrophage+colony+stimulating+factor+%28GM-CSF%29+and+macrophage+colony+stimulating+factor+%28CSF-1%29+synergize+to+stimulate+progenitor+cells+with+high+proliferative+potential.&rft.au=Falk%2C+L+A%3BVogel%2C+S+N&rft.aulast=Falk&rft.aufirst=L&rft.date=1988-11-01&rft.volume=44&rft.issue=5&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-14 N1 - Date created - 1988-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Bradykinin-mediated edema formation is blocked by levorotatory but not dextrorotatory terbutaline. AN - 78743694; 3244331 AB - The ability of the purified stereoisomers of the beta 2-receptor agonist terbutaline to block bradykinin-mediated increases in lymph flow and protein concentration was assessed in the canine forelimb perfused at constant arterial flow. Intra-arterial infusion of bradykinin (2 micrograms/min, n = 8) decreased forelimb arterial pressures but did not affect skin small vein pressure or systemic pressure. Lymph flow, protein concentration and protein transport were significantly increased. Intra-arterial infusion of 1-terbutaline (1 microgram/min, n = 9) decreased forelimb arterial pressures and systemic pressure but did not affect lymph parameters. Subsequent infusion of bradykinin during the continued infusion of 1-terbutaline failed to alter forelimb lymph parameters. Intra-arterial infusion of d-terbutaline (1 microgram/min, n = 11) did not alter vascular pressures or lymph parameters. Subsequent infusion of bradykinin during the continued infusion of d-terbutaline decreased forelimb arterial pressures and significantly increased lymph flow, protein concentration and protein transport. Intra-arterial infusion of a high dose (100 micrograms/min, n = 9) of d-terbutaline significantly decreased forelimb arterial pressure but was likewise ineffective in blocking the increases in lymph parameters produced by subsequent bradykinin infusion. These data indicate that the beta 2-receptor agonistic and anti-permeability actions of terbutaline are found solely in the levorotatory enantiomer. JF - Microcirculation, endothelium, and lymphatics AU - Dobbins, D E AU - Buehn, M J AU - Dabney, J M AD - Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 377 EP - 397 VL - 4 IS - 5 SN - 0740-9451, 0740-9451 KW - Proteins KW - 0 KW - Terbutaline KW - N8ONU3L3PG KW - Bradykinin KW - S8TIM42R2W KW - Index Medicus KW - Animals KW - Stereoisomerism KW - Lymph -- analysis KW - Injections, Intra-Arterial KW - Forelimb KW - Lymphatic System -- drug effects KW - Dogs KW - Proteins -- analysis KW - Blood Pressure -- drug effects KW - Skin -- blood supply KW - Male KW - Female KW - Structure-Activity Relationship KW - Edema -- chemically induced KW - Bradykinin -- antagonists & inhibitors KW - Terbutaline -- pharmacology KW - Bradykinin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78743694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microcirculation%2C+endothelium%2C+and+lymphatics&rft.atitle=Bradykinin-mediated+edema+formation+is+blocked+by+levorotatory+but+not+dextrorotatory+terbutaline.&rft.au=Dobbins%2C+D+E%3BBuehn%2C+M+J%3BDabney%2C+J+M&rft.aulast=Dobbins&rft.aufirst=D&rft.date=1988-10-01&rft.volume=4&rft.issue=5&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Microcirculation%2C+endothelium%2C+and+lymphatics&rft.issn=07409451&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-26 N1 - Date created - 1989-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Antagonism of dermorphin-induced catalepsy with naloxone, TRH-analog CG3703 and the benzodiazepine antagonist, Ro 15-1788. AN - 78718626; 2907115 AB - Intracerebroventricular (i.c.v.) administration of the highly selective opiate mu-receptor agonist, dermorphin, produced dose-dependent catalepsy in conscious rats. The cataleptic effect of dermorphin was abolished by pretreatment (intraperitoneal, i.p.) with the opiate-antagonist naloxone (5 mg/kg), thyrotropin-releasing hormone analog CG3703 (1 mg/kg) or the benzodiazepine-antagonist Ro 15-1788 (5 mg/kg) whereas pretreatment with the benzodiazepine alprazolam (1 mg/kg) potentiated the cataleptic effect of dermorphin. When given to cataleptic rats, naloxone and CG3703, but not Ro 15-1788, reversed the dermorphin-induced catalepsy. The data suggest an involvement of benzodiazepine receptors in the induction of catalepsy mediated by opioid mu-receptors. Other opioid-modulating neuronal systems, antagonized by CG3703, may be involved in maintaining the dermorphin-induced cataleptic state. JF - Neuropharmacology AU - Paakkari, P AU - Feuerstein, G AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 1007 EP - 1012 VL - 27 IS - 10 SN - 0028-3908, 0028-3908 KW - Analgesics, Opioid KW - 0 KW - Oligopeptides KW - Opioid Peptides KW - dermorphin KW - 2SEC01B703 KW - montirelin KW - 30MUJ6YYUY KW - Naloxone KW - 36B82AMQ7N KW - Flumazenil KW - 40P7XK9392 KW - Thyrotropin-Releasing Hormone KW - 5Y5F15120W KW - Alprazolam KW - YU55MQ3IZY KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Alprazolam -- pharmacology KW - Male KW - Injections, Intraventricular KW - Thyrotropin-Releasing Hormone -- pharmacology KW - Naloxone -- pharmacology KW - Thyrotropin-Releasing Hormone -- analogs & derivatives KW - Catalepsy -- chemically induced KW - Oligopeptides -- administration & dosage KW - Analgesics, Opioid -- antagonists & inhibitors KW - Oligopeptides -- antagonists & inhibitors KW - Oligopeptides -- toxicity KW - Flumazenil -- pharmacology KW - Analgesics, Opioid -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78718626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Antagonism+of+dermorphin-induced+catalepsy+with+naloxone%2C+TRH-analog+CG3703+and+the+benzodiazepine+antagonist%2C+Ro+15-1788.&rft.au=Paakkari%2C+P%3BFeuerstein%2C+G&rft.aulast=Paakkari&rft.aufirst=P&rft.date=1988-10-01&rft.volume=27&rft.issue=10&rft.spage=1007&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-02 N1 - Date created - 1989-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Isolation and characterization of monoclonal antibodies to Shiga-like toxin II of enterohemorrhagic Escherichia coli and use of the monoclonal antibodies in a colony enzyme-linked immunosorbent assay. AN - 78495258; 3053764 AB - The major obstacle in large-scale epidemiological investigations of the incidence of Shiga-like toxin (SLT)-producing Escherichia coli in diarrheal stools is the lack of a rapid, specific test to detect toxin. Enterohemorrhagic E. coli produces elevated levels of SLT-I, SLT-II, or both cytotoxins (also called Verotoxins). SLT-I but not SLT-II can be neutralized by antiserum to purified Shiga toxin and by monoclonal antibodies to the B subunit of SLT-I. In this study, monoclonal antibodies were generated against a crude preparation of SLT-II produced by an E. coli K-12 strain lysogenized with the 933W toxin-converting phage of enterohemorrhagic E. coli 933. Hybridoma culture supernatants were screened for anti-SLT-II antibodies by a cytotoxicity neutralization assay and by an enzyme-linked immunosorbent assay (ELISA). Of 53 ELISA-positive lines, 5 were capable of neutralizing the cytotoxicity of SLT-II but not of SLT-I, Shiga toxin, or a variant of SLT-II produced by E. coli that causes edema disease of swine. All five monoclonal antibodies immunoprecipitated the isolated A subunit of SLT-II but not the B subunit. Of these five neutralizing monoclonal antibodies, four were of the immunoglobulin M class and one belonged to the immunoglobulin G1 subclass. All five lines had kappa light chains. These neutralizing monoclonal antibodies have been used as probes in a colony ELISA to detect SLT-II-positive bacterial colonies. The colony ELISA with these monoclonal antibodies is a specific, sensitive test with potential diagnostic value. JF - Journal of clinical microbiology AU - Perera, L P AU - Marques, L R AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 2127 EP - 2131 VL - 26 IS - 10 SN - 0095-1137, 0095-1137 KW - Antibodies, Monoclonal KW - 0 KW - Bacterial Toxins KW - Shiga Toxin 1 KW - Index Medicus KW - Animals KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Mice, Inbred BALB C KW - Female KW - Antibodies, Monoclonal -- biosynthesis KW - Escherichia coli -- metabolism KW - Bacterial Toxins -- analysis KW - Escherichia coli -- pathogenicity KW - Bacterial Toxins -- toxicity KW - Bacterial Toxins -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78495258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Isolation+and+characterization+of+monoclonal+antibodies+to+Shiga-like+toxin+II+of+enterohemorrhagic+Escherichia+coli+and+use+of+the+monoclonal+antibodies+in+a+colony+enzyme-linked+immunosorbent+assay.&rft.au=Perera%2C+L+P%3BMarques%2C+L+R%3BO%27Brien%2C+A+D&rft.aulast=Perera&rft.aufirst=L&rft.date=1988-10-01&rft.volume=26&rft.issue=10&rft.spage=2127&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-12-01 N1 - Date created - 1988-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1970 Aug 15;227(5259):680-5 [5432063] Microb Pathog. 1987 Feb;2(2):147-53 [3333796] J Immunol. 1976 Nov;117(5 Pt 1):1482-90 [187693] Infect Immun. 1980 Oct;30(1):170-9 [7002787] Natl Inst Anim Health Q (Tokyo). 1980 Fall;20(3):116-7 [7019731] Anal Biochem. 1981 Apr;112(2):195-203 [6266278] J Biol Chem. 1981 Aug 25;256(16):8732-8 [7021550] Infect Immun. 1982 Jun;36(3):996-1005 [7047403] Infect Immun. 1983 May;40(2):675-83 [6341244] Infect Immun. 1983 Dec;42(3):914-23 [6196297] J Exp Med. 1984 Dec 1;160(6):1767-81 [6392471] Vet Rec. 1985 Feb 23;116(8):217-8 [3885557] J Infect Dis. 1985 May;151(5):775-82 [3886804] Infect Immun. 1985 Dec;50(3):695-700 [3905611] J Clin Microbiol. 1985 Oct;22(4):614-9 [3908473] Infect Immun. 1986 Jul;53(1):135-40 [3522426] J Infect Dis. 1986 Aug;154(2):338-41 [3522760] J Infect Dis. 1987 Mar;155(3):377-89 [3543152] J Infect Dis. 1987 Apr;155(4):707-15 [3546519] Microbiol Rev. 1987 Jun;51(2):206-20 [3299029] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] J Bacteriol. 1988 Sep;170(9):4223-30 [3045088] Microb Pathog. 1987 Jul;3(1):21-30 [3143036] J Immunol. 1975 Dec;115(6):1617-24 [1102604] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Recombinant interleukin-1 alpha and recombinant tumor necrosis factor alpha synergize in vivo to induce early endotoxin tolerance and associated hematopoietic changes. AN - 78419924; 3262089 AB - Endotoxin, the lipopolysaccharide (LPS) derived from gram-negative bacteria, invokes a wide range of responses in susceptible hosts. It is known that virtually all responses to LPS are mediated by the action of macrophage-derived cytokines (such as interleukin-1 [IL-1], tumor necrosis factor [TNF], and others) which are produced principally by macrophages and maximally within several hours of LPS administration. One manifestation of LPS administration which is not well understood is the phenomenon of "early endotoxin tolerance." In response to a single sublethal injection of LPS, experimental animals become refractory to challenge with a homologous or heterologous LPS preparation 3 to 4 days later. Animals rendered tolerant exhibit mitigated toxicity and a reduced capacity to produce circulating cytokines (i.e., colony-stimulating factor or interferon) in response to the challenge LPS injection. Previous studies have also shown that this state of transient, acquired hyporesponsiveness to LPS is accompanied by a marked increase in the size of cells in the bone marrow which are enriched in numbers of macrophage progenitors. In this study, we examined the capacity of recombinant IL-1 or recombinant TNF or both to induce early endotoxin tolerance and its associated hematopoietic changes. Neither cytokine alone was able to mimic LPS for induction of tolerance. Combined administration of recombinant IL-1 and recombinant TNF doses which were not toxic when administered individually led to synergistic toxicity (as assessed by death or weight loss). However, within a nontoxic range, the two cytokines synergized to induce a significant reduction in the capacity to produce colony-stimulating factor in response to LPS, as well as the characteristic increase in bone marrow cell size and macrophage progenitors shown previously to be associated with LPS-induced tolerance. JF - Infection and immunity AU - Vogel, S N AU - Kaufman, E N AU - Tate, M D AU - Neta, R AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1988/10// PY - 1988 DA - October 1988 SP - 2650 EP - 2657 VL - 56 IS - 10 SN - 0019-9567, 0019-9567 KW - Colony-Stimulating Factors KW - 0 KW - Endotoxins KW - Interleukin-1 KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Bone Marrow Cells KW - Drug Tolerance KW - Animals KW - Body Weight -- drug effects KW - Colony-Stimulating Factors -- biosynthesis KW - Mice KW - Drug Synergism KW - Tumor Necrosis Factor-alpha -- toxicity KW - Hematopoiesis -- drug effects KW - Interleukin-1 -- toxicity KW - Endotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78419924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Recombinant+interleukin-1+alpha+and+recombinant+tumor+necrosis+factor+alpha+synergize+in+vivo+to+induce+early+endotoxin+tolerance+and+associated+hematopoietic+changes.&rft.au=Vogel%2C+S+N%3BKaufman%2C+E+N%3BTate%2C+M+D%3BNeta%2C+R&rft.aulast=Vogel&rft.aufirst=S&rft.date=1988-10-01&rft.volume=56&rft.issue=10&rft.spage=2650&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-26 N1 - Date created - 1988-10-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1965 Oct 30;208(5009):456-8 [4956238] Science. 1985 Aug 30;229(4716):869-71 [3895437] Trans Assoc Am Physicians. 1968;81:334-44 [5721410] Infect Immun. 1982 Nov;38(2):681-5 [6183219] J Immunol. 1985 Dec;135(6):3763-71 [3905964] J Immunol. 1985 Dec;135(6):3969-71 [2999235] Infect Immun. 1986 Apr;52(1):6-11 [3514464] J Immunol. 1986 Apr 15;136(8):3025-31 [3485678] Science. 1986 May 23;232(4753):977-80 [3754653] J Exp Med. 1986 Jun 1;163(6):1433-50 [3486936] Infect Immun. 1986 Sep;53(3):707-10 [3488965] Fed Proc. 1987 Jan;46(1):97-104 [3542580] J Immunol. 1987 Apr 1;138(7):2143-8 [3494061] J Immunol. 1987 Sep 15;139(6):1861-6 [3497980] J Immunol. 1988 Jan 1;140(1):108-11 [2447166] Proc Natl Acad Sci U S A. 1988 Jan;85(2):607-11 [3422444] FASEB J. 1988 Feb;2(2):108-15 [3277884] J Clin Invest. 1988 Apr;81(4):1162-72 [3258319] J Immunol. 1988 Apr 1;140(7):2260-6 [2450915] J Leukoc Biol. 1988 Apr;43(4):349-56 [3258346] Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70 [1103152] J Immunol. 1980 Apr;124(4):2004-9 [6154089] Infect Immun. 1983 Jul;41(1):1-5 [6602767] Science. 1985 Apr 12;228(4696):149-54 [3856324] Biochemistry. 1967 Aug;6(8):2363-72 [4867999] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Field bioassays of permethrin-treated uniforms and a new extended duration repellent against mosquitoes in Pakistan. AN - 78561752; 2904480 AB - Field bioassays were conducted to evaluate the effectiveness of different treatment combinations of permethrin-impregnated clothing and a new extended duration repellent formulation of deet against natural populations of mosquitoes in Islamabad, Pakistan. Tests were initiated 2-2 1/2 hours prior to sunset and volunteers who wore the topical repellent applied it 8 hours earlier. The most effective treatment was a combination of wearing both the permethrin-impregnated clothing and the repellent on exposed skin. This combination provided 100% protection from bites whereas volunteers wearing only treated clothing received 57% protection. Those wearing only repellent received 89% protection, but, under the biting pressure observed, this was not significantly different from the treated clothing-repellent combination. JF - Journal of the American Mosquito Control Association AU - Sholdt, L L AU - Schreck, C E AU - Qureshi, A AU - Mammino, S AU - Aziz, A AU - Iqbal, M AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 233 EP - 236 VL - 4 IS - 3 SN - 8756-971X, 8756-971X KW - Biological Factors KW - 0 KW - Insect Repellents KW - Pyrethrins KW - Nitric Oxide KW - 31C4KY9ESH KW - Permethrin KW - 509F88P9SZ KW - Index Medicus KW - Animals KW - Pakistan KW - Humans KW - Protective Clothing KW - Insect Bites and Stings -- prevention & control KW - Culicidae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78561752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Mosquito+Control+Association&rft.atitle=Field+bioassays+of+permethrin-treated+uniforms+and+a+new+extended+duration+repellent+against+mosquitoes+in+Pakistan.&rft.au=Sholdt%2C+L+L%3BSchreck%2C+C+E%3BQureshi%2C+A%3BMammino%2C+S%3BAziz%2C+A%3BIqbal%2C+M&rft.aulast=Sholdt&rft.aufirst=L&rft.date=1988-09-01&rft.volume=4&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Mosquito+Control+Association&rft.issn=8756971X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-26 N1 - Date created - 1989-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prevention and treatment of the gastric symptoms of radiation sickness. AN - 78469075; 3174940 AB - Currently available treatments for radiation-induced nausea and vomiting either are ineffective or reduce performance. The new antiemetic and gastrokinetic agent zacopride was tested in rhesus monkeys to assess its behavioral toxicity and its ability to inhibit radiation-induced emesis. Zacopride (intragastric, 0.3 mg/kg) or a placebo was given blindly and randomly in the basal state and 15 min before a whole-body 800 cGy 60Co gamma-radiation dose (except for the legs which were partially protected to permit survival of some bone marrow). We determined (1) gastric emptying rates; (2) the presence and frequency of retching and vomiting; and (3) the effect of zacopride on the performance of a visual discrimination task in nonirradiated subjects. No vomiting, retching, or decreased performance was observed after either placebo or zacopride in the control state. Following irradiation plus placebo, 70 emeses were observed in 5 of 6 monkeys, and 353 retches were observed in all 6 monkeys. In contrast, only 1 emesis was observed in 1 of 6 monkeys and 173 retches were seen in 4 of 6 monkeys after irradiation plus zacopride (P less than 0.01). Zacopride also significantly inhibited radiation-induced suppression of gastric emptying. When given after the first vomiting episode in a separate group of irradiated monkeys, zacopride completely prevented any subsequent vomiting. The present results demonstrate that intragastric administration of zacopride significantly inhibited radiation-induced retching, vomiting, and suppression of gastric emptying in rhesus monkeys and did not cause detectable behavioral side effects when given to nonradiated monkeys. This observation has important implications in the treatment of radiation sickness. JF - Radiation research AU - Dubois, A AU - Fiala, N AU - Boward, C A AU - Bogo, V AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 595 EP - 604 VL - 115 IS - 3 SN - 0033-7587, 0033-7587 KW - Benzamides KW - 0 KW - Bridged Bicyclo Compounds KW - Bridged Bicyclo Compounds, Heterocyclic KW - Bridged-Ring Compounds KW - zacopride KW - 9GN3OT4156 KW - Index Medicus KW - Space life sciences KW - Behavior, Animal -- drug effects KW - Animals KW - Discrimination (Psychology) -- drug effects KW - Macaca mulatta KW - Male KW - Radiation Injuries, Experimental -- complications KW - Gastrointestinal Diseases -- drug therapy KW - Bridged Bicyclo Compounds -- pharmacology KW - Gastrointestinal Diseases -- etiology KW - Bridged Bicyclo Compounds -- toxicity KW - Benzamides -- pharmacology KW - Bridged Bicyclo Compounds -- therapeutic use KW - Gastrointestinal Diseases -- prevention & control KW - Bridged-Ring Compounds -- therapeutic use KW - Benzamides -- toxicity KW - Benzamides -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78469075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Prevention+and+treatment+of+the+gastric+symptoms+of+radiation+sickness.&rft.au=Dubois%2C+A%3BFiala%2C+N%3BBoward%2C+C+A%3BBogo%2C+V&rft.aulast=Dubois&rft.aufirst=A&rft.date=1988-09-01&rft.volume=115&rft.issue=3&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-08 N1 - Date created - 1988-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Eosinophiluria. AN - 78442309; 2458885 AB - Hansel's stain is a simple technique that can easily be performed in a clinical or office setting. It allows for improved detection of the eosinophiluria when compared with conventional Wright's stain. The mechanism underlying the superiority of the Hansel's stain remains to be elucidated. Eosinophiluria demonstrated by Hansel's stain appears to be a sensitive marker for drug-induced acute interstitial nephritis and probably allows differentiation from acute tubular necrosis. However, the spectrum of eosinophiluria also includes acute glomerulonephritis, rapidly progressive glomerulonephritis, prostatitis, and urinary tract obstruction. Therefore, the finding of eosinophiluria on Hansel's stain clearly cannot be considered diagnostic of acute interstitial nephritis. In the absence of renal biopsy or other clinical clues to suggest the diagnosis, eosinophiluria should not be used as the sole criterion for the diagnosis of acute interstitial nephritis or a a justification for empiric steroid therapy. JF - Clinics in laboratory medicine AU - Nolan, C R AU - Kelleher, S P AD - Uniformed Services University of the Health Sciences. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 555 EP - 565 VL - 8 IS - 3 SN - 0272-2712, 0272-2712 KW - Index Medicus KW - Urine -- cytology KW - Humans KW - Staining and Labeling KW - Nephritis, Interstitial -- chemically induced KW - Eosinophils KW - Nephritis, Interstitial -- urine KW - Drug Hypersensitivity -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78442309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+laboratory+medicine&rft.atitle=Eosinophiluria.&rft.au=Nolan%2C+C+R%3BKelleher%2C+S+P&rft.aulast=Nolan&rft.aufirst=C&rft.date=1988-09-01&rft.volume=8&rft.issue=3&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Clinics+in+laboratory+medicine&rft.issn=02722712&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-07 N1 - Date created - 1988-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A double dose of phenylpropanolamine causes transient hypertension. AN - 78416199; 3414729 AB - Phenylpropanolamine is widely used and freely available without a doctor's prescription in drug and grocery stores; it is the active ingredient in most diet aids and many cold preparations. Several cases of multiple cerebral hemorrhages associated with transient hypertension have recently been attributed to phenylpropanolamine in dosages equal to or less than that contained in two diet aids (i.e., 150 mg). Some evidence also exists on the additive effects of the co-ingestion of phenylpropanolamine and caffeine. We therefore undertook a study to demonstrate that a significant health risk can be caused by a double dose of a typical over-the-counter (OTC) diet aid (i.e., 150 mg phenylpropanolamine) and also when 75 mg phenylpropanolamine is taken with caffeine. Five men and one woman, ranging in age from 20 to 30, participated in this study. The drug preparations were administered to each subject on different study days in a double-blind, randomized-crossover design. Identical capsules contained 75 mg sustained-release phenylpropanolamine, 400 mg of sustained-release caffeine, or placebo. Subjects ingested three capsules at the beginning of each study day. For 150 mg, two phenylpropanolamine-containing capsules and one placebo were taken; for 75 mg, one phenylpropanolamine capsule and two placebos; and for phenylpropanolamine plus caffeine, one 75 mg phenylpropanolamine capsule, one 400 mg caffeine capsule, and one placebo. Blood pressure and heart rate were monitored throughout the study. Although 75 mg of phenylpropanolamine did not cause clinically relevant hypertension in our subjects, 150 mg of phenylpropanolamine and 75 mg of phenylpropanolamine plus 400 mg caffeine did result in significant blood pressure increases into the hypertensive range. We believe that consumers often assume that double the recommended dosage of an OTC drug is safe and more effective. We suggest that requiring a physician's prescription or an additional, stronger warning label on phenylpropanolamine-containing products may prevent substantial mortality and morbidity. JF - The American journal of medicine AU - Lake, C R AU - Zaloga, G AU - Clymer, R AU - Quirk, R M AU - Chernow, B AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland 20814-4799. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 339 EP - 343 VL - 85 IS - 3 SN - 0002-9343, 0002-9343 KW - Delayed-Action Preparations KW - 0 KW - Phenylpropanolamine KW - 33RU150WUN KW - Caffeine KW - 3G6A5W338E KW - Abridged Index Medicus KW - Index Medicus KW - Drug Interactions KW - Double-Blind Method KW - Random Allocation KW - Humans KW - Adult KW - Caffeine -- pharmacology KW - Monitoring, Physiologic KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Phenylpropanolamine -- adverse effects KW - Hypertension -- chemically induced KW - Hypertension -- physiopathology KW - Phenylpropanolamine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78416199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=A+double+dose+of+phenylpropanolamine+causes+transient+hypertension.&rft.au=Lake%2C+C+R%3BZaloga%2C+G%3BClymer%2C+R%3BQuirk%2C+R+M%3BChernow%2C+B&rft.aulast=Lake&rft.aufirst=C&rft.date=1988-09-01&rft.volume=85&rft.issue=3&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-03 N1 - Date created - 1988-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swine. AN - 78394744; 3045088 AB - A Shiga-like toxin type II variant (SLT-IIv) is produced by strains of Escherichia coli responsible for edema disease of swine and is antigenically related to Shiga-like toxin type II (SLT-II) of enterohemorrhagic E. coli. However, SLT-IIv is only active against Vero cells, whereas SLT-II is active against both Vero and HeLa cells. The structural genes for SLT-IIv were cloned from E. coli S1191, and the nucleotide sequence was determined and compared with those of other members of the Shiga toxin family. The A subunit genes for SLT-IIv and SLT-II were highly homologous (94%), whereas the B subunit genes were less homologous (79%). The SLT-IIv genes were more distantly related (55 to 60% overall homology) to the genes for Shiga toxin of Shigella dysenteriae type 1 and the nearly identical Shiga-like toxin type I (SLT-I) of enterohemorrhagic E. coli. (These toxins are referred to together as Shiga toxin/SLT-I.) The A subunit of SLT-IIv, like those of other members of this toxin family, had regions of homology with the plant lectin ricin. SLT-IIv did not bind to galactose-alpha 1-4-galactose conjugated to bovine serum albumin, which is an analog of the eucaryotic cell receptor for Shiga toxin/SLT-I and SLT-II. These findings support the hypothesis that SLT-IIv binds to a different cellular receptor than do other members of the Shiga toxin family but has a similar mode of intracellular action. The organization of the SLT-IIv operon was similar to that of other members of the Shiga toxin family. Iron did not suppress SLT-IIv or SLT-II production, in contrast with its effect on Shiga toxin/SLT-I. Therefore, the regulation of synthesis of SLT-IIv and SLT-II differs from that of Shiga toxin/SLT-I. JF - Journal of bacteriology AU - Weinstein, D L AU - Jackson, M P AU - Samuel, J E AU - Holmes, R K AU - O'Brien, A D AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 4223 EP - 4230 VL - 170 IS - 9 SN - 0021-9193, 0021-9193 KW - Bacterial Toxins KW - 0 KW - Cytotoxins KW - Shiga Toxin 1 KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - Swine KW - Ricin -- genetics KW - Animals KW - Genes, Bacterial KW - Sequence Homology, Nucleic Acid KW - Edema -- veterinary KW - Operon KW - Amino Acid Sequence KW - Swine Diseases -- microbiology KW - Cloning, Molecular KW - Promoter Regions, Genetic KW - Base Sequence KW - Escherichia coli Infections -- microbiology KW - Escherichia coli Infections -- veterinary KW - Genes KW - Molecular Sequence Data KW - Vero Cells KW - Edema -- microbiology KW - Bacterial Toxins -- genetics KW - Escherichia coli -- genetics KW - Cytotoxins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78394744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Cloning+and+sequencing+of+a+Shiga-like+toxin+type+II+variant+from+Escherichia+coli+strain+responsible+for+edema+disease+of+swine.&rft.au=Weinstein%2C+D+L%3BJackson%2C+M+P%3BSamuel%2C+J+E%3BHolmes%2C+R+K%3BO%27Brien%2C+A+D&rft.aulast=Weinstein&rft.aufirst=D&rft.date=1988-09-01&rft.volume=170&rft.issue=9&rft.spage=4223&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-06 N1 - Date created - 1988-10-06 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - M21534; GENBANK N1 - SuppNotes - Cited By: Eur J Biochem. 1985 Apr 15;148(2):265-70 [3838723] J Exp Med. 1984 Dec 1;160(6):1767-81 [6392471] Annu Rev Microbiol. 1985;39:615-48 [3904614] J Gen Microbiol. 1985 Nov;131(11):3047-53 [3005476] J Bacteriol. 1986 May;166(2):375-9 [3009393] J Exp Med. 1986 Jun 1;163(6):1391-404 [3519828] Infect Immun. 1986 Jul;53(1):135-40 [3522426] Annu Rev Microbiol. 1986;40:577-605 [3535654] J Biol Chem. 1987 Feb 5;262(4):1779-85 [3543013] J Biol Chem. 1987 Jun 15;262(17):8128-30 [3036799] J Biol Chem. 1987 Jun 25;262(18):8834-9 [3298243] Proc Natl Acad Sci U S A. 1987 Jul;84(13):4364-8 [3299365] J Bacteriol. 1987 Sep;169(9):4313-9 [3040689] J Bacteriol. 1987 Oct;169(10):4759-64 [3308853] Infect Immun. 1987 Nov;55(11):2675-80 [2822579] Infect Immun. 1988 Jan;56(1):106-11 [3121508] J Bacteriol. 1988 Feb;170(2):1015-7 [2828307] J Bacteriol. 1988 Mar;170(3):1116-22 [2830229] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2568-72 [3357883] Biochem Biophys Res Commun. 1988 Apr 29;152(2):674-9 [3284526] Microb Pathog. 1987 Feb;2(2):147-53 [3333796] Vet Rec. 1950 Dec 9;62(49):748-56 [14788575] Br J Exp Pathol. 1955 Oct;36(5):439-46 [13269655] Br J Exp Pathol. 1955 Oct;36(5):447-53 [13269656] Proc Natl Acad Sci U S A. 1974 Apr;71(4):1342-6 [4598299] Infect Immun. 1977 Dec;18(3):775-9 [338490] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] J Bacteriol. 1978 Jun;134(3):1141-56 [149110] Annu Rev Genet. 1979;13:319-53 [94251] J Clin Microbiol. 1980 Sep;12(3):361-6 [7012172] J Mol Biol. 1980 Oct 25;143(2):161-78 [6260957] J Infect Dis. 1982 Dec;146(6):763-9 [6754826] Infect Immun. 1983 May;40(2):675-83 [6341244] Proc Natl Acad Sci U S A. 1983 Jul;80(13):3963-5 [6575390] Science. 1985 Oct 11;230(4722):179-81 [2994228] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Iron regulation of the cloned diphtheria toxin promoter in Escherichia coli. AN - 78384352; 3044999 AB - Regulation of the diphtheria toxin promoter by iron was studied in Escherichia coli by using a galK transcriptional fusion. A fragment of the toxin (tox) operon containing the regulatory region was cloned from corynephage beta into a galK transcription vector such that expression of galK activity was controlled by the tox promoter. When E. coli N100 (a galK mutant) harboring this tox-galK fusion plasmid was grown in Luria broth, the specific activity of galactokinase remained constant throughout the exponential phase of growth. When bacteria were shifted from such high-iron medium into low-iron Luria broth, the specific activity of galactokinase increased rapidly, but induction of galactokinase was prevented by the addition of iron to the medium. Measurement of tox-specific mRNA by dot blot hybridization showed that this regulation occurred at the level of transcription. When the plasmid containing the tox-galK fusion was introduced into a fur mutant of E. coli, expression of galK was maximal in both high-iron and low-iron media; but repressibility of galK by iron in this strain was restored by complementation with the fur+ allele. The tox promoter has significant homology with the consensus sequence for other iron-regulated promoters of E. coli that are controlled by fur. These data indicate that the product of the fur gene can function in E. coli as an iron-dependent repressor for the tox promoter from corynephage beta. JF - Infection and immunity AU - Tai, S P AU - Holmes, R K AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 2430 EP - 2436 VL - 56 IS - 9 SN - 0019-9567, 0019-9567 KW - Diphtheria Toxin KW - 0 KW - Repressor Proteins KW - Iron KW - E1UOL152H7 KW - Galactokinase KW - EC 2.7.1.6 KW - Index Medicus KW - Base Sequence KW - Sequence Homology, Nucleic Acid KW - Genetic Vectors KW - Molecular Sequence Data KW - Transcription, Genetic KW - Plasmids KW - Repressor Proteins -- genetics KW - Galactokinase -- genetics KW - Cloning, Molecular KW - Promoter Regions, Genetic -- drug effects KW - Iron -- pharmacology KW - Escherichia coli -- drug effects KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology KW - Diphtheria Toxin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78384352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Iron+regulation+of+the+cloned+diphtheria+toxin+promoter+in+Escherichia+coli.&rft.au=Tai%2C+S+P%3BHolmes%2C+R+K&rft.aulast=Tai&rft.aufirst=S&rft.date=1988-09-01&rft.volume=56&rft.issue=9&rft.spage=2430&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-04 N1 - Date created - 1988-10-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1969 Jun;3(6):586-98 [4978942] J Gen Microbiol. 1960 Jun;22:705-12 [13819397] Proc Natl Acad Sci U S A. 1974 Jan;71(1):11-5 [4204202] Bacteriol Rev. 1975 Mar;39(1):54-85 [164179] Annu Rev Biochem. 1977;46:69-94 [20040] Gene. 1977;2(2):95-113 [344137] J Bacteriol. 1978 Aug;135(2):511-6 [98519] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] J Infect Dis. 1980 Dec;142(6):892-8 [7007526] Anal Biochem. 1981 Apr;112(2):295-8 [6266279] J Bacteriol. 1981 Oct;148(1):131-42 [6270059] J Bacteriol. 1981 Oct;148(1):153-62 [6270061] Mol Gen Genet. 1981;182(2):288-92 [7026976] J Biol Chem. 1982 Aug 10;257(15):9205-10 [6178738] J Bacteriol. 1983 Apr;154(1):245-52 [6403502] Science. 1983 Apr 29;220(4596):515-7 [6403984] Science. 1983 Aug 26;221(4613):855-8 [6348945] J Bacteriol. 1983 Sep;155(3):1439-42 [6411692] Proc Natl Acad Sci U S A. 1983 Sep;80(17):5235-9 [6310567] J Bacteriol. 1983 Nov;156(2):680-5 [6313613] Nucleic Acids Res. 1983 Oct 11;11(19):6589-95 [6314249] Proc Natl Acad Sci U S A. 1983 Nov;80(22):6853-7 [6316330] J Biol Chem. 1983 Dec 25;258(24):15016-20 [6317684] Infect Immun. 1984 Jul;45(1):143-9 [6429042] J Biol Chem. 1984 Jun 25;259(12):7399-403 [6736011] Mol Gen Genet. 1984;197(2):337-41 [6097798] J Bacteriol. 1985 Jun;162(3):1039-46 [2581932] Nucleic Acids Res. 1985 May 10;13(9):3147-59 [3923442] J Bacteriol. 1985 Sep;163(3):1114-9 [2411714] Mol Gen Genet. 1985;200(1):110-3 [2993806] J Biol Chem. 1986 Aug 15;261(23):10797-801 [3015941] J Bacteriol. 1987 May;169(5):2044-9 [3032906] J Bacteriol. 1987 Jun;169(6):2624-30 [3294800] J Bacteriol. 1987 Sep;169(9):4313-9 [3040689] J Bacteriol. 1987 Oct;169(10):4759-64 [3308853] Infect Immun. 1988 Jan;56(1):106-11 [3121508] J Bacteriol. 1988 Feb;170(2):1015-7 [2828307] Microbiol Rev. 1987 Dec;51(4):509-18 [2963952] Gene Amplif Anal. 1981;2:383-415 [6101056] Nat New Biol. 1971 Sep 1;233(35):8-11 [4999827] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Malignant pheochromocytoma: effective treatment with a combination of cyclophosphamide, vincristine, and dacarbazine. AN - 78327182; 3395037 AB - To determine the efficacy and toxicity of combination chemotherapy in patients with advanced, malignant pheochromocytoma. Nonrandomized, single-arm trial. Governmental medical referral center. Fourteen patients with malignant pheochromocytoma confirmed by histologic tests. All patients had metastatic disease and elevated urinary catecholamine secretion. After optimization of antihypertensive therapy, patients received cyclophosphamide, 750 mg/m2 body surface area on day 1; vincristine, 1.4 mg/m2 on day 1, and dacarbazine, 600 mg/m2 on days 1 and 2, every 21 days. Combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine produced a complete and partial response rate of 57% (median duration, 21 months; range, 7 to more than 34). Complete and partial biochemical responses were seen in 79% of patients (median duration, more than 22 months; range, 6 to more than 35). All responding patients had objective improvement in performance status and blood pressure. Toxicity included expected hematologic, neurologic, and gastrointestinal effects of chemotherapy without serious sequelae. There were four minor hypotensive episodes and one minor hypertensive episode. Combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine is effective for advanced malignant pheochromocytoma. Urinary catecholamines are useful to ascertain biochemical response to therapy. JF - Annals of internal medicine AU - Averbuch, S D AU - Steakley, C S AU - Young, R C AU - Gelmann, E P AU - Goldstein, D S AU - Stull, R AU - Keiser, H R AD - National Cancer Institute, Uniformed Services, University of the Health Sciences, Bethesda, Maryland. Y1 - 1988/08/15/ PY - 1988 DA - 1988 Aug 15 SP - 267 EP - 273 VL - 109 IS - 4 SN - 0003-4819, 0003-4819 KW - Biomarkers, Tumor KW - 0 KW - Catecholamines KW - Metanephrine KW - 5001-33-2 KW - Vanilmandelic Acid KW - 55-10-7 KW - Vincristine KW - 5J49Q6B70F KW - Dacarbazine KW - 7GR28W0FJI KW - Cyclophosphamide KW - 8N3DW7272P KW - Abridged Index Medicus KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Humans KW - Vincristine -- administration & dosage KW - Adult KW - Biomarkers, Tumor -- analysis KW - Vanilmandelic Acid -- analysis KW - Dacarbazine -- administration & dosage KW - Middle Aged KW - Adolescent KW - Catecholamines -- analysis KW - Female KW - Male KW - Adrenal Gland Neoplasms -- drug therapy KW - Metanephrine -- analysis KW - Pheochromocytoma -- secondary KW - Pheochromocytoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Pheochromocytoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78327182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Malignant+pheochromocytoma%3A+effective+treatment+with+a+combination+of+cyclophosphamide%2C+vincristine%2C+and+dacarbazine.&rft.au=Averbuch%2C+S+D%3BSteakley%2C+C+S%3BYoung%2C+R+C%3BGelmann%2C+E+P%3BGoldstein%2C+D+S%3BStull%2C+R%3BKeiser%2C+H+R&rft.aulast=Averbuch&rft.aufirst=S&rft.date=1988-08-15&rft.volume=109&rft.issue=4&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-25 N1 - Date created - 1988-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Naloxone potentiates epinephrine's pressor actions in endotoxemic rats. AN - 78445652; 3048771 AB - Naloxone's pressor effects in shock may be mediated through antagonism of endogenous opioid inhibition of sympathoadrenal catecholaminergic systems. Since circulating catecholamine levels are not further elevated by naloxone in endotoxemic animals, it is possible that naloxone acts upon opiate receptors to enhance catecholamine actions at the receptor or postreceptor level. To investigate this hypothesis, we sought to determine whether naloxone treatment would augment the pressor actions of exogenous catecholamines (epinephrine) in normal and endotoxemic rats. Naloxone (3 mg/kg intravenous [i.v.] bolus followed by 3 mg/ml/hr infusion) significantly augmented the pressor response to 10, 20, and 50 micrograms/kg of i.v. epinephrine by 69%, 48% and 14%, respectively, in endotoxin (5 mg/kg, LD20, i.v.) -treated rats but not in normal rats. Likewise, the duration of the pressor response to epinephrine was significantly increased by naloxone. These findings suggest that the coadministration of naloxone and epinephrine may be of benefit in the treatment of shock. JF - Circulatory shock AU - Malcolm, D S AU - Zaloga, G P AU - Willey, S C AU - Amir, S AU - Holaday, J W AD - Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 259 EP - 265 VL - 25 IS - 4 SN - 0092-6213, 0092-6213 KW - Naloxone KW - 36B82AMQ7N KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Heart Rate -- drug effects KW - Escherichia coli KW - Drug Synergism KW - Male KW - Naloxone -- pharmacology KW - Shock, Septic -- chemically induced KW - Epinephrine -- pharmacology KW - Shock, Septic -- physiopathology KW - Blood Pressure -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78445652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulatory+shock&rft.atitle=Naloxone+potentiates+epinephrine%27s+pressor+actions+in+endotoxemic+rats.&rft.au=Malcolm%2C+D+S%3BZaloga%2C+G+P%3BWilley%2C+S+C%3BAmir%2C+S%3BHoladay%2C+J+W&rft.aulast=Malcolm&rft.aufirst=D&rft.date=1988-08-01&rft.volume=25&rft.issue=4&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Circulatory+shock&rft.issn=00926213&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-03 N1 - Date created - 1988-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Radiation-associated lesions of the chest wall. AN - 78335208; 3400030 AB - A ten year review of 31 patients with chest wall complications associated with radiation therapy is presented. Carcinoma of the breast accounted for 23 instances, postradiation sarcomas for five and other complications for three. Twenty patients had radionecrotic ulcerations, nine of which were found to contain recurrent malignant disease. This finding significantly and unfavorably influenced survival in comparison with those whose ulcer was free of tumor (p less than or equal to 0.0001). Of 27 surgically treated patients, the regimen which correlated with the fewest complications included extensive removal of all poor quality tissue, avoidance of prosthetic materials and bone grafts and immediate reconstruction with well vascularized muscle or omental flaps. JF - Surgery, gynecology & obstetrics AU - Seyfer, A E AD - Division of Plastic and Reconstructive Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 129 EP - 131 VL - 167 IS - 2 SN - 0039-6087, 0039-6087 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Thoracic Neoplasms -- radiotherapy KW - Aged KW - Middle Aged KW - Surgical Flaps KW - Neoplasm Recurrence, Local KW - Breast Neoplasms -- radiotherapy KW - Male KW - Female KW - Radiation Injuries -- surgery KW - Thoracic Injuries -- surgery KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78335208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Surgery%2C+gynecology+%26+obstetrics&rft.atitle=Radiation-associated+lesions+of+the+chest+wall.&rft.au=Seyfer%2C+A+E&rft.aulast=Seyfer&rft.aufirst=A&rft.date=1988-08-01&rft.volume=167&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Surgery%2C+gynecology+%26+obstetrics&rft.issn=00396087&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-02 N1 - Date created - 1988-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Prospects for management of gastrointestinal injury associated with the acute radiation syndrome. AN - 78304408; 3292340 AB - The effect of total-body ionizing radiation on the digestive tract is dose-dependent and time-dependent. At low doses (1.5 Gy), one observes only a short prodromal syndrome consisting of nausea, vomiting, and gastric suppression. At doses greater than 6 Gy, the prodromal syndrome is more marked, and it is followed after a 2-5-day remission period by a subacute syndrome, characterized by diarrhea and hematochezia. This gastrointestinal syndrome is superimposed onto a radiation-induced bone marrow suppression. The combination of intestinal and hemopoietic syndromes results in dehydration, anemia, and infection, leading eventually to irreversible shock and death. The treatment of prodromal symptoms is based on the administration of antiemetics and gastrokinetics, although an effective treatment devoid of side effects is not yet available for human therapy. The treatment of the gastrointestinal subacute syndrome remains difficult and unsuccessful after exposure to total body doses greater than 8-10 Gy. Supportive therapy to prevent infection and dehydration may be effective if restoration or repopulation of the intestinal and bone marrow stem cells does occur. In addition, bone marrow transplantation may improve the prospect of treating the hemopoietic syndrome, although the experience gained in Chernobyl suggests that this treatment is difficult to apply in the case of nuclear accidents. Administration of radioprotectants before irradiation decreases damage to healthy cells, while not protecting cancerous tissues. In the future, stimulation of gastrointestinal and hemopoietic progenitor cells may be possible using cell growth regulators, but much remains to be done to improve the treatment of radiation damage to the gastrointestinal tract. JF - Gastroenterology AU - Dubois, A AU - Walker, R I AD - Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 500 EP - 507 VL - 95 IS - 2 SN - 0016-5085, 0016-5085 KW - Antiemetics KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Radiation Dosage KW - Antiemetics -- therapeutic use KW - Accidents KW - Humans KW - Ukraine KW - Dose-Response Relationship, Radiation KW - Nuclear Reactors KW - Bone Marrow Transplantation KW - Gastrointestinal Diseases -- therapy KW - Gastrointestinal Diseases -- etiology KW - Digestive System -- radiation effects KW - Radiation Injuries -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78304408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Prospects+for+management+of+gastrointestinal+injury+associated+with+the+acute+radiation+syndrome.&rft.au=Dubois%2C+A%3BWalker%2C+R+I&rft.aulast=Dubois&rft.aufirst=A&rft.date=1988-08-01&rft.volume=95&rft.issue=2&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-12 N1 - Date created - 1988-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Psychiatric side effects attributed to phenylpropanolamine. AN - 78599465; 3060884 AB - Phenylpropanolamine (PPA) is a sympathomimetic drug similar in structure to amphetamine which, in the United States, is present in over 130 medications, primarily decongestants, cough/cold remedies, and anorectic agents. We have reviewed 37 cases (published in North America and Europe since 1960) that received diagnoses of acute mania, paranoid schizophrenia, and organic psychosis and that were attributed to PPA product ingestion. Of the 27 North American case reports, more reactions followed the ingestion of combination products than preparations containing PPA alone; more occurred after ingestion of over-the-counter products than those obtained by prescription or on-the-street; and more of the cases followed ingestion of recommended doses than overdoses. Groups at particular risk appear to be those with a past or family psychiatric history, children under the age of 6 and post-partum women. Failure to recognize PPA as an etiological agent in the onset of symptoms usually led to a diagnosis of schizophrenia or mania, lengthy hospitalization, and treatment with substantial doses of neuroleptics or lithium. While generally safe at recommended doses, PPA can be hazardous to susceptible individuals and we urge physicians to be alert to the potential for PPA related psychiatric reactions. We have compiled an alphabetized table (Table 1: Prescription and Over-the-Counter Products Containing Phenylpropanolamine) allowing busy clinicians quick access to those drugs containing PPA. JF - Pharmacopsychiatry AU - Lake, C R AU - Masson, E B AU - Quirk, R S AD - Dept. of Psychiatry, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 171 EP - 181 VL - 21 IS - 4 SN - 0176-3679, 0176-3679 KW - Phenylpropanolamine KW - 33RU150WUN KW - Index Medicus KW - Infant KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Phenylpropanolamine -- adverse effects KW - Mental Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78599465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacopsychiatry&rft.atitle=Psychiatric+side+effects+attributed+to+phenylpropanolamine.&rft.au=Lake%2C+C+R%3BMasson%2C+E+B%3BQuirk%2C+R+S&rft.aulast=Lake&rft.aufirst=C&rft.date=1988-07-01&rft.volume=21&rft.issue=4&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Pharmacopsychiatry&rft.issn=01763679&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-02-06 N1 - Date created - 1989-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Emergence and persistence of beta-lactamase-producing bacteria in the oropharynx following penicillin treatment. AN - 85223863; pmid-3130087 AB - The emergence and persistence of aerobic and anaerobic beta-lactamase-producing bacteria (BLPB) were investigated in 26 children treated with penicillin for otitis media or pharyngitis and in 28 nontreated control children. beta-Lactamase-producers were isolated in three (12%) of the treated children before therapy, in 12 (46%) seven to ten days after completion of therapy, in nine (35%) 40 to 45 days after therapy, and in seven (27%) 85 to 90 days after therapy. These organisms were present in three (11%) of the nontreated children, and the number of patients harboring BLPB stayed constant throughout the three-month follow-up. The predominant BLPB were Bacteroides species (Bacteroides melaninogenicus group, Bacteroides oralis, and Bacteroides oris-buccae), Staphylococcus aureus, Haemophilus influenzae, and Branhamella catarrhalis. The emergence and persistence of BLPB after penicillin therapy may have important implications for the antimicrobial management of infections of the upper respiratory tract. JF - Archives of Otolaryngology--Head and Neck Surgery AU - Brook, I AD - Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Md. PY - 1988 SP - 667 EP - 670 VL - 114 IS - 6 SN - 0886-4470, 0886-4470 KW - Bacteria KW - Penicillins KW - Penicillin V KW - Haemophilus influenzae KW - Oropharynx KW - Bacteroides KW - Humans KW - Otitis Media KW - Ampicillin KW - Child KW - Pharyngitis KW - beta-Lactamases KW - Child, Preschool KW - Moraxella (Branhamella) catarrhalis KW - Adolescent KW - Staphylococcus aureus KW - Time Factors KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85223863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Emergence+and+persistence+of+beta-lactamase-producing+bacteria+in+the+oropharynx+following+penicillin+treatment.&rft.au=Brook%2C+I&rft.aulast=Brook&rft.aufirst=I&rft.date=1988-06-01&rft.volume=114&rft.issue=6&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Archives+of+Otolaryngology--Head+and+Neck+Surgery&rft.issn=08864470&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effects of cage beddings on microsomal oxidative enzymes in rat liver. AN - 78386013; 3411916 AB - The purpose of the present studies was to evaluate the effects of some commercially available cage beddings on rat liver microsomal cytochrome P-450-dependent drug-metabolizing enzyme, ethylmorphine N-demethylase, and the carcinogen-metabolizing enzyme, benzo(a)pyrene hydroxylase. Sprague-Dawley rats were housed in cages containing cedar chip, corncob or heat-treated pinewood bedding for 3 weeks. Control rats were housed in cages on wire bottom floors containing no bedding material. Rats housed in cages containing cedar chip showed 18, 46 and 49% increases in liver cytochrome P-450 content, ethylmorphine N-demethylase and benzo(a)pyrene hydroxylase activities, respectively. The liver enzyme activities of rats housed in cages containing corncob bedding were similar to those obtained with control rats. In contrast, the pinewood-bedded rats showed a 21% decrease in ethylmorphine N-demethylase activity without affecting cytochrome P-450 content and benzo(a)pyrene hydroxylase activity. Hexobarbital-induced sleep times of the variously bedded rats were similar to those of control animals. These data suggest that the commercial bedding materials differ in their abilities to affect liver microsomal enzymes. Thus, interlaboratory variability in basal enzyme activities reported in the literature may be partly due to bedding materials used in the animal's cages. JF - Laboratory animal science AU - Weichbrod, R H AU - Cisar, C F AU - Miller, J G AU - Simmonds, R C AU - Alvares, A P AU - Ueng, T H AD - Department of Laboratory Animal Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 296 EP - 298 VL - 38 IS - 3 SN - 0023-6764, 0023-6764 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Benzopyrene Hydroxylase KW - EC 1.14.14.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Oxidoreductases, N-Demethylating KW - EC 1.5.- KW - Ethylmorphine-N-Demethylase KW - EC 1.5.3.- KW - Ethylmorphine KW - RWO67D87EU KW - Index Medicus KW - Rats KW - Animals KW - Ethylmorphine -- metabolism KW - Random Allocation KW - Enzyme Induction KW - Cytochrome P-450 Enzyme System -- metabolism KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Animals, Laboratory KW - Benzo(a)pyrene -- metabolism KW - Ethylmorphine-N-Demethylase -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Benzopyrene Hydroxylase -- biosynthesis KW - Benzopyrene Hydroxylase -- metabolism KW - Microsomes, Liver -- enzymology KW - Housing, Animal KW - Ethylmorphine-N-Demethylase -- biosynthesis KW - Oxidoreductases, N-Demethylating -- metabolism KW - Rats, Inbred Strains -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78386013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+animal+science&rft.atitle=Effects+of+cage+beddings+on+microsomal+oxidative+enzymes+in+rat+liver.&rft.au=Weichbrod%2C+R+H%3BCisar%2C+C+F%3BMiller%2C+J+G%3BSimmonds%2C+R+C%3BAlvares%2C+A+P%3BUeng%2C+T+H&rft.aulast=Weichbrod&rft.aufirst=R&rft.date=1988-06-01&rft.volume=38&rft.issue=3&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=Laboratory+animal+science&rft.issn=00236764&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-29 N1 - Date created - 1988-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determinants of survival of patients with epithelial ovarian carcinoma following whole abdomen irradiation (WAR). AN - 78229669; 3371745 AB - In an attempt to identify those parameters which represent predictors of clinical outcome, a retrospective review of patients with epithelial ovarian carcinoma who were primarily treated with whole abdominal irradiation (WAR) following staging laparotomy was performed. Complete records with extensive long-term follow-up were available on 102 patients treated from 1962 through 1974. Histopathologic review excluded 18 patients with lesions of low malignant potential. Of the remaining 84 cases there were 12 Stage I (14%), 23 Stage II (27%), 45 Stage III (54%), and 4 Stage IV (5%). Measure of completeness of surgical resection was expressed as the largest diameter of residual gross tumor. Following primary surgical debulking Stages II and III patients, 24 patients had no gross residual disease, 24 patients had less than 2 cm of residual disease, and 20 patients had greater than 2 cm of residual disease. For Stages II and III patients together, 5- and 10-year actuarial survivals were: No gross residual, 69% and 59%; less than 2 cm, 48% and 42%; and greater than 2 cm, 15% and 10%. The technique of administration of WAR did not appear to influence survival. The results of this review support the concept that in selecting WAR for primary treatment of ovarian carcinoma, completeness of cytoreductive surgery should be considered. These data justify a prospective randomized study in patients with minimal residual disease following staging laparotomy comparing WAR with current first-line combination chemotherapy. JF - Gynecologic oncology AU - Weiser, E B AU - Burke, T W AU - Heller, P B AU - Woodward, J AU - Hoskins, W J AU - Park, R C AD - Department of Obstetrics and Gynecology, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 201 EP - 208 VL - 30 IS - 2 SN - 0090-8258, 0090-8258 KW - Index Medicus KW - Evaluation Studies as Topic KW - Neoplasm Staging KW - Radiotherapy Dosage KW - Humans KW - Abdomen KW - Adult KW - Retrospective Studies KW - Aged KW - Radiotherapy -- methods KW - Middle Aged KW - Actuarial Analysis KW - Female KW - Radiotherapy -- adverse effects KW - Ovarian Neoplasms -- radiotherapy KW - Ovarian Neoplasms -- mortality KW - Carcinoma -- pathology KW - Ovarian Neoplasms -- pathology KW - Carcinoma -- radiotherapy KW - Carcinoma -- complications KW - Ovarian Neoplasms -- complications KW - Carcinoma -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78229669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gynecologic+oncology&rft.atitle=Determinants+of+survival+of+patients+with+epithelial+ovarian+carcinoma+following+whole+abdomen+irradiation+%28WAR%29.&rft.au=Weiser%2C+E+B%3BBurke%2C+T+W%3BHeller%2C+P+B%3BWoodward%2C+J%3BHoskins%2C+W+J%3BPark%2C+R+C&rft.aulast=Weiser&rft.aufirst=E&rft.date=1988-06-01&rft.volume=30&rft.issue=2&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Gynecologic+oncology&rft.issn=00908258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-06 N1 - Date created - 1988-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The Impact of Technology Transfer on the Structure of the Saudi Arabian Labor Force AN - 61594249; 198901459 AB - The employment & productivity patterns that have resulted from Saudi Arabia's rapid importation of Western technology are explored here in light of the major differences between its economy & other Third World economies. Despite huge investments in industry, the industrial LF is proportionally small & overwhelmingly composed of foreign workers. While oil revenues provide the key to development & an abundance of fixed capital, economic success is still elusive due to shortages of labor, management skills, & organization. 2 Tables. A. Waters JF - Journal of Economic Issues AU - Looney, Robert E AD - United States Naval Postgraduate School, Monterey CA 93940 Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 485 EP - 492 VL - 22 IS - 2 SN - 0021-3624, 0021-3624 KW - employment/productivity, Saudi Arabia KW - Western technology importation KW - Saudi Arabia KW - Employment Opportunities KW - Technology Transfer KW - Productivity KW - article KW - 8370: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61594249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Economic+Issues&rft.atitle=The+Impact+of+Technology+Transfer+on+the+Structure+of+the+Saudi+Arabian+Labor+Force&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1988-06-01&rft.volume=22&rft.issue=2&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Journal+of+Economic+Issues&rft.issn=00213624&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Technology Transfer; Employment Opportunities; Saudi Arabia; Productivity ER - TY - JOUR T1 - Comparison of the microbiology of group A and non-group A streptococcal tonsillitis. AN - 85182432; pmid-3132074 AB - We studied the microbial flora of tonsils removed from 20 children who suffered from recurrent group A beta-hemolytic streptococcal (GABHS) tonsillitis and 20 who had tonsillar hypertrophy following recurrent non-GABHS tonsillitis. Similar polymicrobial aerobic and anaerobic flora were recovered from the cores of the tonsils in each group. beta-Lactamase-producing bacteria (BLPB) were recovered more often in the group with GABHS. This difference was due mostly to the lower incidence of beta-lactamase-producing strains of Branhamella catarrhalis and Bacteroides sp in hypertrophic tonsils following non-GABHS tonsillitis. beta-Lactamase-producing Staphylococcus aureus was found with equal frequency in both groups. These findings demonstrate that although BLPB are recovered more often in recurrently inflamed tonsils following GABHS infection, BLPB also can be found in hypertrophic tonsils following non-GABHS tonsillitis. JF - The Annals of Otology, Rhinology, and Laryngology AU - Brook, I AU - Yocum, P AD - Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland. PY - 1988 SP - 243 EP - 246 VL - 97 IS - 3 Pt 1 SN - 0003-4894, 0003-4894 KW - Bacterial Infections KW - Humans KW - Child KW - beta-Lactamases KW - Recurrence KW - Streptococcus pyogenes KW - Child, Preschool KW - Moraxella (Branhamella) catarrhalis KW - Tonsil KW - Streptococcal Infections KW - Tonsillitis KW - Staphylococcus aureus KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85182432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.atitle=Comparison+of+the+microbiology+of+group+A+and+non-group+A+streptococcal+tonsillitis.&rft.au=Brook%2C+I%3BYocum%2C+P&rft.aulast=Brook&rft.aufirst=I&rft.date=1988-05-01&rft.volume=97&rft.issue=3+Pt+1&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+Otology%2C+Rhinology%2C+and+Laryngology&rft.issn=00034894&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Ultraviolet-induced dimerization of non-adjacent pyrimidines. A potential mechanism for the targeted -1 frameshift mutation. AN - 78401004; 3270507 AB - The DNA photoproduct responsible for the ultraviolet (u.v.)-induced targeted -1 frameshift mutation is unknown. Based on mutagenesis studies by others, we surmised that this lesion might be found in high abundance in single-stranded DNA. u.v. irradiation of the single-stranded alternating copolymer poly[d(G-T)] yielded a photoproduct that was characterized in detail. It consists of a thymine-thymine cyclobutane dimer of predominantly cis-syn configuration occurring between non-adjacent thymidyl residues on the same strand. Its formation is strongly inhibited in double-stranded DNA. A similar u.v. photoproduct was obtained in higher yield from the polypyrimidine alternating copolymer poly[d(C-T)] under conditions in which it is single-stranded. It is proposed that replication across the unrepaired photoproduct: (formula; see text) is the cause of the targeted u.v.-induced -1 frameshift mutation. JF - Journal of molecular biology AU - Nguyen, H T AU - Minton, K W AD - Department of Pathology, F. E. Herbert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1988/04/20/ PY - 1988 DA - 1988 Apr 20 SP - 681 EP - 693 VL - 200 IS - 4 SN - 0022-2836, 0022-2836 KW - Polydeoxyribonucleotides KW - 0 KW - Pyrimidine Dimers KW - poly d(C-T) KW - 49717-92-2 KW - polydeoxy(guanine-thymine) nucleotide KW - 55684-98-5 KW - Index Medicus KW - Polydeoxyribonucleotides -- radiation effects KW - Chromatography, Thin Layer KW - Dose-Response Relationship, Radiation KW - Nucleic Acid Conformation KW - Ultraviolet Rays KW - Pyrimidine Dimers -- radiation effects KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78401004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Ultraviolet-induced+dimerization+of+non-adjacent+pyrimidines.+A+potential+mechanism+for+the+targeted+-1+frameshift+mutation.&rft.au=Nguyen%2C+H+T%3BMinton%2C+K+W&rft.aulast=Nguyen&rft.aufirst=H&rft.date=1988-04-20&rft.volume=200&rft.issue=4&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-27 N1 - Date created - 1988-09-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Mol Biol Aug 5;208(3):515 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Beta-lactamase-producing bacteria in head and neck infection. AN - 85190274; pmid-3258396 AB - We have summarized our experience in recovery of beta-lactamase-producing bacteria (BLPB) in head and neck infection (HNI). These HNI include conjunctivitis, serous and chronic otitis media, cholesteatoma, chronic mastoiditis, chronic sinusitis, adenoiditis, recurrent tonsillitis in children and adults, peritonsillar abscess, and retropharyngeal abscess. Beta-lactamase-producing bacteria were found in 262 (51%) of 513 patients with HNI; 72% had aerobic BLPB and 57% had anaerobic BLPB. The infections, where these organisms were most frequently recovered, were adenoiditis (85% of patients), tonsillitis in adults (82%) and children (74%), retropharyngeal abscess (71%), and chronic otitis media (57%). The predominant BLPB were Staphylococcus aureus (49% of patients with BLPB), the Bacteroides-melaninogenicus group (28%), the Bacteroides fragilis group (20%), Pseudomonas aeruginosa (13%), Hemophilus influenzae (5%), and Branhamella catarrhalis (3%). The high incidence of recovery of BLPB in head and neck infections may have important implications on the antimicrobial management of these infections. JF - The Laryngoscope AU - Brook, I AD - Department of Pediatrics and Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD. PY - 1988 SP - 428 EP - 431 VL - 98 IS - 4 SN - 0023-852X, 0023-852X KW - Bacterial Infections KW - Haemophilus Infections KW - Human KW - Cholesteatoma KW - Child KW - Conjunctivitis KW - Sinusitis KW - beta-Lactamases KW - Ear Diseases KW - Pharyngeal Diseases KW - Staphylococcal Infections KW - Pseudomonas Infections KW - Bacteroides Infections UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85190274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Beta-lactamase-producing+bacteria+in+head+and+neck+infection.&rft.au=Brook%2C+I&rft.aulast=Brook&rft.aufirst=I&rft.date=1988-04-01&rft.volume=98&rft.issue=4&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The Political Economy of Third World Military Expenditures: Impact of Regime Type on the Defense Allocation Process AN - 61008946; 89U1709 AB - To develop an empirically verifiable framework for explaining patterns of Third World defense expenditures two areas of research are merged that previously have been examined somewhat separately -- economic (or ability to spend) with political (willingness to allocate resources to defense). Analysis of secondary data indicates that military regimes are committed to developing the size of the defense sector to levels not warranted by economic size per se through extensive use of externally borrowed funds. They use increases in foreign exchange earnings to expand defense allocations, & distort their price systems in a manner that facilitates increased defense expenditures. It is concluded that ability & willingness factors, rather than external conditions, are instrumental in affecting Third World military expenditures. 1 Table, 31 References. HA JF - Journal of Political and Military Sociology AU - Looney, Robert E AD - US Naval Postgraduate School, Monterey CA 93940 Y1 - 1988/04// PY - 1988 DA - April 1988 SP - 21 EP - 29 VL - 16 IS - 1 SN - 0047-2697, 0047-2697 KW - military expenditures, Third World regimes KW - ability/willingness factors KW - secondary data KW - Developing Countries KW - Political Economy KW - Armed Forces KW - National Security KW - article KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61008946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Political+and+Military+Sociology&rft.atitle=The+Political+Economy+of+Third+World+Military+Expenditures%3A+Impact+of+Regime+Type+on+the+Defense+Allocation+Process&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1988-04-01&rft.volume=16&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Journal+of+Political+and+Military+Sociology&rft.issn=00472697&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JPMSCG N1 - SubjectsTermNotLitGenreText - National Security; Armed Forces; Developing Countries; Political Economy ER - TY - JOUR T1 - Breast cancer in relation to early use of oral contraceptives. No evidence of a latent effect. AN - 78128233; 3343791 AB - A long-term effect of oral contraceptives (OCs) on breast cancer risk has been suggested as an explanation for some studies' failure to detect an association between OCs and breast cancer. To address this latency hypothesis, we analyzed data on 4714 case subjects and 4540 control subjects from the population-based Cancer and Steroid Hormone Study. No support was evident for a latent effect of OCs on breast cancer risk through age 54 years: among parous women who had cumulated more than six years of OC use before their first term pregnancy, the risk of breast cancer, relative to nonusers before first term pregnancy, was 0.6 at zero to four years after first term pregnancy (95% confidence interval [Cl], 0.2 to 1.8), 0.7 at five to nine years (95% Cl, 0.3 to 1.7), and 1.1 at ten to 14 years (95% Cl, 0.3 to 3.9). Among nulliparous women with more than six years of OC use in total, the relative risk of breast cancer, by interval from last use of OCs, was 1.3 at zero to four years (95% Cl, 0.8 to 2.0), 1.1 at five to nine years (95% Cl, 0.5 to 2.0), and 0.6 at ten to 14 years (95% Cl, 0.1 to 3.7). JF - JAMA AU - Schlesselman, J J AU - Stadel, B V AU - Murray, P AU - Lai, S AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda 20814. Y1 - 1988/03/25/ PY - 1988 DA - 1988 Mar 25 SP - 1828 EP - 1833 VL - 259 IS - 12 SN - 0098-7484, 0098-7484 KW - Contraceptives, Oral, Combined KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Time Factors KW - Female KW - Breast Neoplasms -- epidemiology KW - Breast Neoplasms -- chemically induced KW - Contraceptives, Oral, Combined -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78128233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Breast+cancer+in+relation+to+early+use+of+oral+contraceptives.+No+evidence+of+a+latent+effect.&rft.au=Schlesselman%2C+J+J%3BStadel%2C+B+V%3BMurray%2C+P%3BLai%2C+S&rft.aulast=Schlesselman&rft.aufirst=J&rft.date=1988-03-25&rft.volume=259&rft.issue=12&rft.spage=1828&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-07 N1 - Date created - 1988-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Environmental stress, reactivity and ischaemic heart disease. AN - 78183069; 3129010 AB - This article provides an overview of work in two areas of biobehavioural research: the effects of environmental stress and the role of psychophysiologic reactivity in the development of ischaemic heart disease. Attention is given first to evidence that low socio-economic status, low social support, and occupational settings characterized by high demands and low levels of control over the job are associated with increased coronary risk. Also discussed is a promising animal primate model of social stress and its role in development of coronary atherosclerosis. Next, we discuss physiological responsiveness (reactivity) to emotional stress, which is being studied as a marker of processes involved in the development of cardiovascular disease. Stress and psychophysiological reactivity constitute promising targets for research on biobehavioural antecedents of coronary disease and for clinical intervention studies. However, further evidence is needed before these variables can be regarded as proven coronary risk factors. JF - The British journal of medical psychology AU - Krantz, D S AU - Raisen, S E AD - Department of Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 3 EP - 16 VL - 61 ( Pt 1) SN - 0007-1129, 0007-1129 KW - Index Medicus KW - Animals KW - Humans KW - Occupational Diseases -- complications KW - Disease Models, Animal KW - Social Support KW - Male KW - Haplorhini KW - Female KW - Coronary Disease -- etiology KW - Stress, Psychological -- physiopathology KW - Coronary Disease -- physiopathology KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78183069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+medical+psychology&rft.atitle=Environmental+stress%2C+reactivity+and+ischaemic+heart+disease.&rft.au=Krantz%2C+D+S%3BRaisen%2C+S+E&rft.aulast=Krantz&rft.aufirst=D&rft.date=1988-03-01&rft.volume=61+%28+Pt+1%29&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+medical+psychology&rft.issn=00071129&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-09 N1 - Date created - 1988-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A recurrent intertriginous rash responsive to topical as well as surgical therapy. Necrolytic migratory erythema with saprophytic superinfection. AN - 78119939; 2830850 JF - Archives of dermatology AU - Dons, R F AU - Cashell, A W AD - Uniformed Services University of the Health Sciences and Naval Hospital, Bethesda, Md. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 431 EP - 431, 434 VL - 124 IS - 3 SN - 0003-987X, 0003-987X KW - Hydroxyquinolines KW - 0 KW - Iodoquinol KW - 63W7IE88K8 KW - Abridged Index Medicus KW - Index Medicus KW - Buttocks KW - Humans KW - Groin KW - Adult KW - Recurrence KW - Female KW - Administration, Topical KW - Erythema -- pathology KW - Hydroxyquinolines -- therapeutic use KW - Erythema -- complications KW - Iodoquinol -- adverse effects KW - Erythema -- drug therapy KW - Glucagonoma -- surgery KW - Iodoquinol -- therapeutic use KW - Skin Diseases, Infectious -- pathology KW - Adenoma, Islet Cell -- complications KW - Skin Diseases, Infectious -- drug therapy KW - Pancreatic Neoplasms -- complications KW - Glucagonoma -- complications KW - Skin Diseases, Infectious -- complications KW - Pancreatic Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78119939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=A+recurrent+intertriginous+rash+responsive+to+topical+as+well+as+surgical+therapy.+Necrolytic+migratory+erythema+with+saprophytic+superinfection.&rft.au=Dons%2C+R+F%3BCashell%2C+A+W&rft.aulast=Dons&rft.aufirst=R&rft.date=1988-03-01&rft.volume=124&rft.issue=3&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=0003987X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-31 N1 - Date created - 1988-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Stimulation of the renal endoplasmic reticulum calcium pump: a possible biomarker for platinate toxicity. AN - 78106966; 2963406 AB - Antitumor platinum compounds such as cisplatin are frequently nephrotoxic. The mechanism of nephrotoxicity has not been determined. It has been proposed that some toxicants may act by interfering with the mechanisms that control cellular Ca2+ homeostasis. An important factor in the regulation of cytosolic Ca2+ is the endoplasmic reticulum (ER) calcium pump. The activity of this pump was determined by measuring ATP-dependent microsomal sequestration of 45Ca. Administration of nephrotoxic doses of platinum compounds to rats was associated with an increase in renal ER calcium pump activity. This was the earliest response observed after cisplatin treatment (it occurred within 4 hr) and preceded increases in blood urea nitrogen and serum creatinine by at least 1 day. The dose-response curve for the increase in renal ER calcium pump activity was similar to the increase in the number and size of smooth ER aggregates observed in the S3 segment of the proximal tubule 24 hr following cisplatin administration. Only minor morphological changes were observed at this time. There was a significant increase in calcium content of kidneys of rats 24 hr after treatment with a dose of cisplatin that caused a maximal increase in ER calcium pump activity. This indicates that a disruption of normal calcium homeostasis may occur before histological evidence of nephrotoxicity. Platinates that were not toxic to the kidney did not elevate renal ER calcium pump activity. It is suggested that the activity of the ER calcium pump may be a useful biomarker for cellular toxicity and may be a factor in the mechanism of toxicity. JF - Toxicology and applied pharmacology AU - De Witt, L M AU - Jones, T W AU - Moore, L AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 157 EP - 169 VL - 92 IS - 2 SN - 0041-008X, 0041-008X KW - Antineoplastic Agents KW - 0 KW - Organoplatinum Compounds KW - iproplatin KW - 5R9F9NE9Z2 KW - Creatinine KW - AYI8EX34EU KW - Calcium-Transporting ATPases KW - EC 3.6.3.8 KW - Cisplatin KW - Q20Q21Q62J KW - ormaplatin KW - SFK1SGY8V1 KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Liver -- enzymology KW - Liver -- drug effects KW - Blood Urea Nitrogen KW - Creatinine -- blood KW - Male KW - Endoplasmic Reticulum -- enzymology KW - Kidney -- pathology KW - Cisplatin -- toxicity KW - Kidney -- enzymology KW - Kidney -- drug effects KW - Antineoplastic Agents -- toxicity KW - Organoplatinum Compounds -- toxicity KW - Calcium-Transporting ATPases -- metabolism KW - Endoplasmic Reticulum -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78106966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Stimulation+of+the+renal+endoplasmic+reticulum+calcium+pump%3A+a+possible+biomarker+for+platinate+toxicity.&rft.au=De+Witt%2C+L+M%3BJones%2C+T+W%3BMoore%2C+L&rft.aulast=De+Witt&rft.aufirst=L&rft.date=1988-02-01&rft.volume=92&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Biochemical evaluation of rat hepatocyte primary cultures as a model for carbon tetrachloride hepatotoxicity: comparative studies in vivo and in vitro. AN - 78103566; 2963407 AB - In order to evaluate how well the development of CCl4 hepatotoxicity in vivo can be modeled in primary cultures of rat hepatocytes, biochemical alterations were determined in liver samples from rats given CCl4 and in liver cells cultured for 18 hr then exposed to CCl4. Soluble thiol levels matched closely between tissue and hepatocytes (11 vs 12 micrograms-SH/mg protein) prior to exposure. Comparable concentrations of CCl4 were measured in blood (0.30 mM at 30 min) and in culture medium (0.49 mM at 5 min). Simultaneous inhibition of the endoplasmic reticulum calcium pump and stimulation of phosphorylase a activity occurred at early times in vivo (30 min) and in vitro (5 min). Glucose-6-phosphatase was inhibited next in liver (120 min) and in cells (20 min). 5'-Nucleotidase was not affected at any time points examined in either system. Leakage of glutamic-pyruvic transaminase and depletion of glycogen were maximal at later times in vivo (greater than or equal to 8 hr) and in cells (30 min). Total calcium content was increased severalfold in liver tissue (24 hr), but was not elevated in hepatocytes. This lack of calcium accumulation in cells appeared to result from impaired mitochondrial calcium uptake. Thus CCl4-induced biochemical changes followed nearly the same continuum in both models, although the progression was much more rapid in vitro than in vivo. JF - Toxicology and applied pharmacology AU - Long, R M AU - Moore, L AD - Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 295 EP - 306 VL - 92 IS - 2 SN - 0041-008X, 0041-008X KW - Sulfhydryl Compounds KW - 0 KW - Chloramphenicol KW - 66974FR9Q1 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - NADH Dehydrogenase KW - EC 1.6.99.3 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Calcium-Transporting ATPases KW - EC 3.6.3.8 KW - Index Medicus KW - Endoplasmic Reticulum -- enzymology KW - Animals KW - Mitochondria, Liver -- enzymology KW - NADH Dehydrogenase -- metabolism KW - Sulfhydryl Compounds -- metabolism KW - Alanine Transaminase -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Models, Biological KW - Rats, Inbred Strains KW - Rats KW - Chloramphenicol -- pharmacology KW - Cells, Cultured KW - Kinetics KW - Calcium-Transporting ATPases -- metabolism KW - Male KW - Liver -- pathology KW - Liver -- drug effects KW - Liver -- metabolism KW - Carbon Tetrachloride -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78103566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Biochemical+evaluation+of+rat+hepatocyte+primary+cultures+as+a+model+for+carbon+tetrachloride+hepatotoxicity%3A+comparative+studies+in+vivo+and+in+vitro.&rft.au=Long%2C+R+M%3BMoore%2C+L&rft.aulast=Long&rft.aufirst=R&rft.date=1988-02-01&rft.volume=92&rft.issue=2&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Enhancement of cytotoxicity of modeccin by nigericin in modeccin-resistant mutant cell lines. AN - 78087073; 3338496 AB - We have isolated a Chinese hamster ovary cell mutant (DMPR-2) simultaneously resistant to diphtheria toxin and modeccin. In addition to the increased resistance to these two toxins used in the selection, this mutant is more resistant to Pseudomonas toxin and hypersensitive to ricin than the parental cell line. In contrast to the wild-type cells in which nigericin protects cells from modeccin, the cytotoxicity of modeccin in the DMPR-2 mutant is enhanced by nigericin. We have also studied the effects of nigericin and NH4Cl on the cytotoxicity of modeccin in a modeccin-resistant mutant of HeLa cells (ModRI). The cytotoxicity of modeccin is enhanced by nigericin in ModRI mutant cells, in contrast to the protection of modeccin cytotoxicity by nigericin in the parental HeLa cells. Our results suggest that modeccin can reach the cytosol of mammalian cells by two distinct routes; the major route requires endosomal acidification and the minor route is activated by nigericin. JF - Experimental cell research AU - Ghosh, P C AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 397 EP - 410 VL - 174 IS - 2 SN - 0014-4827, 0014-4827 KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Toxins KW - Diphtheria Toxin KW - Lectins KW - Plant Lectins KW - Ribosome Inactivating Proteins, Type 2 KW - Toxins, Biological KW - Transferrin KW - Ammonium Chloride KW - 01Q9PC255D KW - modeccin KW - 65988-88-7 KW - Ricin KW - 9009-86-3 KW - Iron KW - E1UOL152H7 KW - Nigericin KW - RRU6GY95IS KW - Index Medicus KW - Animals KW - Drug Resistance -- genetics KW - HeLa Cells KW - Humans KW - Bacterial Toxins -- pharmacology KW - Pseudomonas KW - Ammonium Chloride -- pharmacology KW - Ricin -- pharmacology KW - Iron -- metabolism KW - Transferrin -- metabolism KW - Ricin -- metabolism KW - Diphtheria Toxin -- pharmacology KW - Drug Synergism KW - Mutation KW - Cell Line KW - Protein Biosynthesis KW - Nigericin -- pharmacology KW - Toxins, Biological -- pharmacology KW - Anti-Bacterial Agents -- pharmacology KW - Lectins -- metabolism KW - Lectins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78087073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Enhancement+of+cytotoxicity+of+modeccin+by+nigericin+in+modeccin-resistant+mutant+cell+lines.&rft.au=Ghosh%2C+P+C%3BWu%2C+H+C&rft.aulast=Ghosh&rft.aufirst=P&rft.date=1988-02-01&rft.volume=174&rft.issue=2&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-23 N1 - Date created - 1988-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The well-baby examination. AN - 85237318; pmid-3276098 AB - Most abnormalities that occur in infancy are detected by the child's parents or by the physician during routine well-baby examinations. Growth parameters should be measured and discussed with the parents. Vision, hearing and speech should be assessed on a regular basis. Emotional disturbances are missed less often if a social-behavioral assessment is included in the evaluation. JF - American Family Physician AU - South-Paul, J E AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland. PY - 1988 SP - 167 EP - 172 VL - 37 IS - 1 SN - 0002-838X, 0002-838X KW - Infant KW - Growth KW - Child Behavior KW - Human KW - Child Development KW - Support, Non-U.S. Gov't KW - Follow-Up Studies KW - Physical Examination KW - Medical History Taking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85237318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Family+Physician&rft.atitle=The+well-baby+examination.&rft.au=South-Paul%2C+J+E&rft.aulast=South-Paul&rft.aufirst=J&rft.date=1988-01-01&rft.volume=37&rft.issue=1&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=American+Family+Physician&rft.issn=0002838X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Socio-Economic Environments and the Budgetary Allocation Process in Developing Countries: The Case of Defense Expenditures AN - 60982605; 89U5320 AB - Typically, policy analysts have assumed that military budgets are determined by exogenous factors (eg, the threat of aggression) & are thus not directly measurable, or can only be crudely quantified by some form of proxy variable. Hence, the link between determinants of defense spending & the level of military expenditures has not been amenable to traditional economic analysis. It is argued that any forecast of military expenditures that excludes economic factors is likely to be sustantially inaccurate. Statistics from the International Monetary Fund, the World Bank, the Yale U (New Haven, Conn) Data Base on Political & Social Indicators, & the US Arms Control & Disarmament Agency are used to analyze the relationship between 33 variables representing 7 major economic factors & military expenditures in 46 countries. Results support the significant role played by economic factors in determining military spending, particularly in the Third World. 6 Tables. Modified HA JF - Socio-Economic Planning Sciences AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943-5100 Y1 - 1988///0, PY - 1988 DA - 0, 1988 SP - 71 EP - 81 VL - 22 IS - 2 SN - 0038-0121, 0038-0121 KW - military expenditures, Third World countries KW - economic factors KW - international data KW - Economic Factors KW - Fiscal Policy KW - Government Policy KW - Armed Forces KW - Economic Planning KW - article KW - 2454: policy, planning, forecasting; planning & forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60982605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Socio-Economic+Planning+Sciences&rft.atitle=Socio-Economic+Environments+and+the+Budgetary+Allocation+Process+in+Developing+Countries%3A+The+Case+of+Defense+Expenditures&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1988-01-01&rft.volume=22&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Socio-Economic+Planning+Sciences&rft.issn=00380121&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SEPSBI N1 - SubjectsTermNotLitGenreText - Fiscal Policy; Economic Factors; Economic Planning; Armed Forces; Government Policy ER - TY - JOUR T1 - Socio-Economic Planning in an Era of Falling Oil Revenues: The Case of Venezuela AN - 60928468; 89U5321 AB - Consequences of continually declining oil revenues on the Venezuelan economy between 1979 & 1983 are explored, with focus on whether the government has been or will be able to sustain the SE programs established during early periods of expanded revenues. Statistical data from the International Monetary Fund & Stockholm International Peace Research Instit are used to construct an econometric time-series model of the economy, & the pattern of SE allocations is forecast through several optimal control simulations. Results indicate that without major changes in national priorities, in terms of security vs SE needs, there are still several strategies open to authorities to allow SE programs to continue until at least 1990. 4 Tables. Modified HA JF - Socio-Economic Planning Sciences AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943-5100 Y1 - 1988///0, PY - 1988 DA - 0, 1988 SP - 57 EP - 70 VL - 22 IS - 2 SN - 0038-0121, 0038-0121 KW - national economy, Venezuela, 1979-1983 KW - declining oil revenues KW - international statistics KW - Venezuela KW - Profits KW - Petroleum Industry KW - Economic Structure KW - Economic Planning KW - article KW - 2454: policy, planning, forecasting; planning & forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60928468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Socio-Economic+Planning+Sciences&rft.atitle=Socio-Economic+Planning+in+an+Era+of+Falling+Oil+Revenues%3A+The+Case+of+Venezuela&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1988-01-01&rft.volume=22&rft.issue=2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Socio-Economic+Planning+Sciences&rft.issn=00380121&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SEPSBI N1 - SubjectsTermNotLitGenreText - Economic Planning; Venezuela; Economic Structure; Petroleum Industry; Profits ER - TY - JOUR T1 - A prospective comparison study of double contrast computed tomography (CT) arthrography and arthroscopy of the shoulder AN - 20751429; 10093093 AB - Thirty consecutive patients who underwent double con trast CT arthrography prior to shoulder arthroscopy were prospectively studied. Results from both studies were recorded with the radiologist blinded to the ar throscopic findings when making the final CT reading. The sensitivity, specificity, and accuracy, respectively, of CT arthrography findings compared to arthroscopy were 50%, 100%, 96% for rotator cuff; 66%, 100% 96% for bicipital labral complex; 100%, 100%, 100% for loose bodies; 50%, 100% 93% for Hill-Sachs le sions ; 90%, 73%, 83% for anterior labral defects; and 100%, 100%, 100% for posterior labral defects. We conclude that shoulder arthroscopy accurately deline ates abnormalities of the anterior and posterior labrum, bicipital labral complex, rotator cuff, joint synovium, and humeral head. CT arthrography accurately delineates capsular redundancy, loose bodies, hardware around joints, and bony glenoid rim abnormalities. JF - American Journal of Sports Medicine AU - Callaghan, John J AU - McNiesh, Lawrence M AU - Dehaven, James P AU - Savory, Carlton G AU - Polly, David W AD - The Walter Reed Army Medical Center, Washington, D.C., and The Uniformed Services University of the Health Sciences, Bethesda, Maryland Y1 - 1988/01// PY - 1988 DA - Jan 1988 SP - 13 EP - 20 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 16 IS - 1 SN - 0363-5465, 0363-5465 KW - Physical Education Index; Biotechnology and Bioengineering Abstracts KW - Reading KW - Head KW - Synovium KW - Specificity KW - Humerus KW - Accuracy KW - Patients KW - Joints KW - arthroscopy KW - Shoulder KW - Surgery KW - Computed tomography KW - Labrum KW - Rotator cuff KW - Language KW - Shoulders KW - Sports medicine KW - W 30910:Imaging KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20751429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=A+prospective+comparison+study+of+double+contrast+computed+tomography+%28CT%29+arthrography+and+arthroscopy+of+the+shoulder&rft.au=Callaghan%2C+John+J%3BMcNiesh%2C+Lawrence+M%3BDehaven%2C+James+P%3BSavory%2C+Carlton+G%3BPolly%2C+David+W&rft.aulast=Callaghan&rft.aufirst=John&rft.date=1988-01-01&rft.volume=16&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354658801600103 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Reading; Specificity; Surgery; Accuracy; Rotator cuff; Patients; Shoulders; Sports medicine; Joints; Synovium; Head; arthroscopy; Humerus; Shoulder; Computed tomography; Labrum; Language DO - http://dx.doi.org/10.1177/036354658801600103 ER - TY - JOUR T1 - N-acetyl-leukotriene E sub(4) is a potent constrictor of rat mesenteric vessels. AN - 15026589; 1837130 AB - N-Acetyl-leukotriene E sub(4) administered to conscious freely moving rats produced a dose-dependent vasoconstriction in the mesenteric vessels which led to profound reduction of blood flow to the gut. Renal and hindquarter blood flow and vascular resistance were not affected even by high doses of N-acetyl-leukotriene E sub(4). N-Acetyl-leukotriene E sub(4) was 10-fold more potent than the thromboxane analog U-46619 and 1000-fold more potent than prostaglandin F sub(2 alpha ) but 2-5-fold less potent than leukotriene D sub(4)/E sub(4) to induce mesenteric vasoconstriction. These data indicate that N-acetyl-leukotriene E sub(4) is a biologically active metabolite of peptide leukotrienes, and might play a role in cardiovascular derangements mediated by leukotrienes. JF - European Journal of Pharmacology AU - Siren, A-L AU - Letts, G AU - Feuerstein, G AD - Dep. Neurol., USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 331 EP - 335 VL - 146 IS - 2-3 SN - 0014-2999, 0014-2999 KW - effects on KW - N-acetyl-leukotriene E sub(4) KW - rats KW - leukotriene E sub(4) KW - Toxicology Abstracts KW - blood pressure KW - X 24111:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15026589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Pharmacology&rft.atitle=N-acetyl-leukotriene+E+sub%284%29+is+a+potent+constrictor+of+rat+mesenteric+vessels.&rft.au=Siren%2C+A-L%3BLetts%2C+G%3BFeuerstein%2C+G&rft.aulast=Siren&rft.aufirst=A-L&rft.date=1988-01-01&rft.volume=146&rft.issue=2-3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - blood pressure ER - TY - JOUR T1 - Production of a Shiga-like cytotoxin by Campylobacter . AN - 14989297; 1805327 AB - Cell lysates and culture supernatants of 36 Campylobacter isolates from patients with enteritis were tested for cytotoxic activity on HeLa cells. Cytotoxic activity was considered Shiga-like if neutralized by monoclonal antibody to the B subunit of Shiga-like toxin I of Escherichia coli and rabbit anti-Shiga-toxin. Fifteen of the Campylobacter isolates produced no detectable cytotoxin, 10 produced a non-neutralizable cytotoxin, and 11 produced low levels of a cell-associated SLT. However, under low stringency conditions no hybridization was observed between a DNA fragment containing cloned SLT-I genes and restriction enzyme-digested total DNA from a Campylobacter strain that produced low levels of a Shiga-like toxin I. The date indicate that low levels of Shiga-like toxin are produced by some Campylobacter isolates but that SLT is genetically distinct from the SLT-I toxin produced at high levels by certain E. coli . The findings suggest that exposure to SLTs is common in the adult population but not as a consequence of infection with C. jejuni or S. sonnei . JF - Microbial Pathogenesis AU - Moore, MA AU - Blaser, MJ AU - Perez-Perez, GI AU - O'Brien, AD AD - Dep. Microbiol., USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA Y1 - 1988 PY - 1988 DA - 1988 SP - 455 EP - 462 VL - 4 IS - 6 SN - 0882-4010, 0882-4010 KW - production KW - Shiga toxin KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - enteritis KW - gastrointestinal tract KW - Campylobacter KW - cytotoxins KW - man KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/14989297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Production+of+a+Shiga-like+cytotoxin+by+Campylobacter+.&rft.au=Moore%2C+MA%3BBlaser%2C+MJ%3BPerez-Perez%2C+GI%3BO%27Brien%2C+AD&rft.aulast=Moore&rft.aufirst=MA&rft.date=1988-01-01&rft.volume=4&rft.issue=6&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Campylobacter; enteritis; cytotoxins; gastrointestinal tract; man ER - TY - JOUR T1 - Breast cancer risk in relation to type of estrogen contained in oral contraceptives. AN - 77998448; 3446437 AB - We report analyses designed to address the recent hypothesis that women who use combination-type OCs containing ethinylestradiol (EE) are at increased risk of breast cancer before age 45, if use of such OCs occurs prior to first term pregnancy (FTP). Our findings, based on data from 1679 cases and 1689 controls, 20-44 years of age, from the population-based Cancer and Steroid Hormone Study, are against the hypothesis. The relative risk of breast cancer by duration of exclusive use prior to FTP of OCs containing EE is estimated to be 1.0 (1-12 months EE use), 1.2 (13-48 months EE use), and 0.9 (49+ months EE use). There was no evidence of a latent effect. Among parous women with 49+ months exclusive use prior to FTP of EE-containing OCs, the relative risk of breast cancer was estimated as 0.9 (0-4 years after FTP) and 0.6 (5-9 years after FTP). Among nulliparous women with 49+ months exclusive use of EE-containing OCs, the relative risk of breast cancer was estimated as 1.0 (0-4 years since first use), 0.7 (5-9 years since first use), and 1.1 (10-14 years since first use). With regard to exclusive use of OCs containing mestranol, parous women who used such preparations long-term before their FTP showed no alteration of breast cancer risk, even 15 years or more after pregnancy. Nulliparous women with exclusive use of ME-containing OCs did show elevations in breast cancer risk, but the magnitude of risk in relation to duration of use and latent interval shows no pattern that suggests a cause-effect relationship. JF - Contraception AU - Schlesselman, J J AU - Stadel, B V AU - Murray, P AU - Lai, S H AD - Department of Preventive Medicine and Biometrics, Uniformed Services, University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1987/12// PY - 1987 DA - December 1987 SP - 595 EP - 613 VL - 36 IS - 6 SN - 0010-7824, 0010-7824 KW - Contraceptives, Oral, Combined KW - 0 KW - Ethinyl Estradiol KW - 423D2T571U KW - Mestranol KW - B2V233XGE7 KW - Index Medicus KW - Population KW - United States KW - Fertility KW - Research Methodology KW - Epidemiologic Methods KW - Population Dynamics KW - Physiology KW - Contraceptive Methods--side effects KW - Breast Cancer KW - Oral Contraceptives--side effects KW - Correlation Studies KW - Hormones KW - Developed Countries KW - Mestranol--side effects KW - First Birth Intervals KW - Contraceptive Agents, Estrogen--side effects KW - Demographic Factors KW - Ethinyl Estradiol--side effects KW - Diseases KW - Family Planning KW - Time Factors KW - Contraceptive Agents--side effects KW - Parity KW - North America KW - Americas KW - Statistical Studies KW - Endocrine System KW - Research Report KW - Studies KW - Longterm Effects KW - Cancer KW - Northern America KW - Neoplasms KW - Birth Intervals KW - Developing Countries KW - Contraceptive Agents, Female--side effects KW - Fertility Measurements KW - Contraception--side effects KW - Biology KW - Risk Factors KW - Humans KW - Adult KW - Female KW - Mestranol -- adverse effects KW - Ethinyl Estradiol -- adverse effects KW - Breast Neoplasms -- chemically induced KW - Contraceptives, Oral, Combined -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77998448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contraception&rft.atitle=Breast+cancer+risk+in+relation+to+type+of+estrogen+contained+in+oral+contraceptives.&rft.au=Schlesselman%2C+J+J%3BStadel%2C+B+V%3BMurray%2C+P%3BLai%2C+S+H&rft.aulast=Schlesselman&rft.aufirst=J&rft.date=1987-12-01&rft.volume=36&rft.issue=6&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Contraception&rft.issn=00107824&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-26 N1 - Date created - 1988-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Common pathways of degenerative arthritis of the wrist. AN - 77863775; 3693419 AB - Carpal arthrosis secondary to scapholunate advanced collapse is described in terms of pathomechanics, radiographic features, and treatment. In addition, a differential diagnosis of carpal arthrosis is presented. Emphasis is placed on the similarity of injury patterns observed in a variety of disease processes affecting the wrist. JF - Hand clinics AU - Harrington, R H AU - Lichtman, D M AU - Brockmole, D M AD - Uniformed Services University of the Health Sciences, Bethesda, Maryland. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 507 EP - 527 VL - 3 IS - 4 SN - 0749-0712, 0749-0712 KW - Calcium Pyrophosphate KW - X69NU20D19 KW - Index Medicus KW - Psoriasis -- complications KW - Osteochondritis -- complications KW - Diagnosis, Differential KW - Humans KW - Arthritis, Rheumatoid -- diagnosis KW - Occupational Diseases -- complications KW - Chondrocalcinosis -- diagnosis KW - Joint Instability -- complications KW - Fractures, Bone -- complications KW - Joint Instability -- physiopathology KW - Gout -- complications KW - Carpal Bones -- injuries KW - Arthritis, Rheumatoid -- complications KW - Chondrocalcinosis -- complications KW - Wrist Joint -- physiopathology KW - Osteoarthritis -- physiopathology KW - Osteoarthritis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77863775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hand+clinics&rft.atitle=Common+pathways+of+degenerative+arthritis+of+the+wrist.&rft.au=Harrington%2C+R+H%3BLichtman%2C+D+M%3BBrockmole%2C+D+M&rft.aulast=Harrington&rft.aufirst=R&rft.date=1987-11-01&rft.volume=3&rft.issue=4&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Hand+clinics&rft.issn=07490712&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-01-29 N1 - Date created - 1988-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Cyclothymic disorder and bromocriptine: predisposing factors for postpartum mania? AN - 77854215; 3690486 AB - Women are most susceptible to psychotic reactions during the postpartum period, a time of intense psychological and physiological stress. Mania and depression are particularly common at this time, especially in women with past or family histories of major or minor affective disorders, specifically cyclothymia and dysthymia. Close attention after childbirth is warranted to alleviate and prevent these episodes in such women. Sympathomimetic drugs such as bromocriptine and the over-the-counter diet aids, which are linked to the induction of manic episodes, are frequently used in the puerperal period and may act as catalysts. This case report documents a postpartum manic episode in a cyclothymic woman who was prescribed bromocriptine, a dopamine agonist, for prevention of lactation. JF - Canadian journal of psychiatry. Revue canadienne de psychiatrie AU - Lake, C R AU - Reid, A AU - Martin, C AU - Chernow, B AD - Department of Psychiatry, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, MD 20814-4799. Y1 - 1987/11// PY - 1987 DA - November 1987 SP - 693 EP - 694 VL - 32 IS - 8 SN - 0706-7437, 0706-7437 KW - Bromocriptine KW - 3A64E3G5ZO KW - Index Medicus KW - AIDS/HIV KW - Lactation -- drug effects KW - Risk Factors KW - Humans KW - Adult KW - Female KW - Pregnancy KW - Puerperal Disorders -- chemically induced KW - Bromocriptine -- adverse effects KW - Mood Disorders -- complications KW - Bromocriptine -- therapeutic use KW - Cyclothymic Disorder -- complications KW - Bipolar Disorder -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77854215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+psychiatry.+Revue+canadienne+de+psychiatrie&rft.atitle=Cyclothymic+disorder+and+bromocriptine%3A+predisposing+factors+for+postpartum+mania%3F&rft.au=Lake%2C+C+R%3BReid%2C+A%3BMartin%2C+C%3BChernow%2C+B&rft.aulast=Lake&rft.aufirst=C&rft.date=1987-11-01&rft.volume=32&rft.issue=8&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Canadian+journal+of+psychiatry.+Revue+canadienne+de+psychiatrie&rft.issn=07067437&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-12 N1 - Date created - 1988-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): implications for drug design. AN - 81084535; 3313391 AB - The malaria parasite has an obligate calcium requirement for normal intracellular growth and invasion of host erythrocytes. Calmodulin (CaM) is a vital calcium-dependent protein present in eukaryotes. We found by radioimmunoassay that free parasites contain CaM. Schizont-infected erythrocytes had CaM levels of 23.3 +/- 2.7 ng per 10(6) cells compared to normals (11.2 +/- 1.5 ng per 10(6) cells). CaM levels were proportional to parasite maturity. Immunoelectron microscopy identified CaM diffusely within the cytoplasm of mature parasites and at the apical end of merozoites within the ductule of rhoptries, which may explain the calcium requirement for invasion. Cyclosporin A (CsA) was also found by electron microscopic autoradiography to concentrate in the food vacuole, as do chloroquine and mefloquine, and to distribute within the cytoplasm of mature parasites. The binding of dansylated CsA to schizont-infected erythrocytes was higher than to normal erythrocytes as analyzed by flow cytometry. Kinetic analysis revealed that binding was saturable for normal and infected erythrocytes and possibly free parasites. Competition for binding existed between dansylated CsA and native CsA as well as the CaM inhibitor W-7 and the classic antimalarial chloroquine. The in vitro growth of Plasmodium falciparum was sensitive to CaM antagonists, and in large part inhibition of the parasite was proportional to known anti-CaM potency. Antagonism existed between combinations of these drugs in multi-drug-resistant strains of P. falciparum, suggesting possible competition for the same binding site. In addition, the malaria parasite was also susceptible to calcium antagonists. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Scheibel, L W AU - Colombani, P M AU - Hess, A D AU - Aikawa, M AU - Atkinson, C T AU - Milhous, W K AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, MD 20814. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 7310 EP - 7314 VL - 84 IS - 20 SN - 0027-8424, 0027-8424 KW - Antimalarials KW - 0 KW - Calcium Channel Blockers KW - Calmodulin KW - Cyclosporins KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Drug Interactions KW - Humans KW - Drug Resistance KW - Calmodulin -- analysis KW - Antimalarials -- pharmacology KW - Plasmodium falciparum -- growth & development KW - Malaria -- drug therapy KW - Calcium Channel Blockers -- pharmacology KW - Calcium -- analysis KW - Plasmodium falciparum -- ultrastructure KW - Calmodulin -- antagonists & inhibitors KW - Calcium -- pharmacology KW - Cyclosporins -- pharmacology KW - Plasmodium falciparum -- drug effects KW - Cyclosporins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81084535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Calcium+and+calmodulin+antagonists+inhibit+human+malaria+parasites+%28Plasmodium+falciparum%29%3A+implications+for+drug+design.&rft.au=Scheibel%2C+L+W%3BColombani%2C+P+M%3BHess%2C+A+D%3BAikawa%2C+M%3BAtkinson%2C+C+T%3BMilhous%2C+W+K&rft.aulast=Scheibel&rft.aufirst=L&rft.date=1987-10-01&rft.volume=84&rft.issue=20&rft.spage=7310&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-25 N1 - Date created - 1987-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Biochem Parasitol. 1983 Mar;7(3):227-35 [6350870] EMBO J. 1987 May;6(5):1421-7 [3301326] Mol Pharmacol. 1981 Sep;20(2):363-70 [6457977] Biochem Biophys Res Commun. 1981 Nov 30;103(2):402-6 [7036992] Am J Trop Med Hyg. 1982 Jul;31(4):711-7 [6808848] J Pharmacol Exp Ther. 1982 Sep;222(3):509-16 [6286920] J Cell Biol. 1982 Jun;93(3):680-4 [6288729] Infect Immun. 1982 Sep;37(3):1093-100 [6752020] Clin Sci (Lond). 1984 May;66(5):497-507 [6142782] Mol Biochem Parasitol. 1983 Nov;9(3):197-208 [6144043] Science. 1985 Apr 19;228(4697):337-9 [3885394] Biochim Biophys Acta. 1985 Jul 31;835(3):448-55 [4016141] Biochem Pharmacol. 1985 Sep 15;34(18):3391-3 [2994682] N Engl J Med. 1985 Oct 17;313(16):995-1002 [2413355] J Clin Invest. 1986 Apr;77(4):1405-8 [3457021] J Parasitol. 1986 Apr;72(2):299-305 [3016225] N Engl J Med. 1986 Sep 11;315(11):712-3 [3748079] Science. 1986 Oct 3;234(4772):68-71 [3749892] Mol Pharmacol. 1986 Oct;30(4):364-9 [2945090] Science. 1987 Feb 20;235(4791):899-901 [3544220] Am J Trop Med Hyg. 1987 Jan;36(1):9-14 [3544894] Am J Pathol. 1972 May;67(2):277-84 [5021103] N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. AN - 81044768; 3660430 AB - Trichothecenes are mycotoxins which produce lethal toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a highly lethal T-2 toxicosis. These data also suggest that PAF is an important mediator of this unique toxicosis. JF - Toxicology letters AU - Feuerstein, G AU - Leader, P AU - Siren, A L AU - Braquet, P AD - Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 271 EP - 274 VL - 38 IS - 3 SN - 0378-4274, 0378-4274 KW - Diterpenes KW - 0 KW - Ginkgolides KW - Lactones KW - Plant Extracts KW - Platelet Activating Factor KW - Sesquiterpenes KW - ginkgolide B KW - DF149B9460 KW - T-2 Toxin KW - I3FL5NM3MO KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - Male KW - Platelet Activating Factor -- antagonists & inhibitors KW - Plant Extracts -- therapeutic use KW - Sesquiterpenes -- toxicity KW - T-2 Toxin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81044768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Protective+effect+of+a+PAF-acether+antagonist%2C+BN+52021%2C+in+trichothecene+toxicosis.&rft.au=Feuerstein%2C+G%3BLeader%2C+P%3BSiren%2C+A+L%3BBraquet%2C+P&rft.aulast=Feuerstein&rft.aufirst=G&rft.date=1987-10-01&rft.volume=38&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-04 N1 - Date created - 1987-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Risk Preference in Military Decision Making: An Empirical Study AN - 60942844; 88T7479 AB - An examination of the risk element in military decision making, based on questionnaire data from 297 US Army officers, in relation to combat, financial, & career path decisions. Findings show that officers are risk aggressive in combat decisions but risk averse in financial decisions. Combat risk aggressiveness is significantly correlated with rank, sex, promotability, & commission source. 3 Tables, 2 Appendixes, 11 References. Modified HA JF - Journal of Political and Military Sociology AU - Eoyang, Carson AU - Liao, Shu S AU - Hayden, Douglas C AU - Thomas, James W AD - US Naval Postgraduate School, Monterey CA 93940 Y1 - 1987/10// PY - 1987 DA - October 1987 SP - 245 EP - 261 VL - 15 IS - 2 SN - 0047-2697, 0047-2697 KW - risk preference, US Army officers KW - combat/financial/career path decisions KW - questionnaires KW - Risk KW - Preferences KW - Military Officers KW - United States of America KW - Armed Forces KW - article KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60942844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Political+and+Military+Sociology&rft.atitle=Risk+Preference+in+Military+Decision+Making%3A+An+Empirical+Study&rft.au=Eoyang%2C+Carson%3BLiao%2C+Shu+S%3BHayden%2C+Douglas+C%3BThomas%2C+James+W&rft.aulast=Eoyang&rft.aufirst=Carson&rft.date=1987-10-01&rft.volume=15&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Journal+of+Political+and+Military+Sociology&rft.issn=00472697&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JPMSCG N1 - SubjectsTermNotLitGenreText - Military Officers; United States of America; Armed Forces; Risk; Preferences ER - TY - JOUR T1 - Upper extremity injuries due to medications. AN - 81023497; 3655235 AB - One hundred eleven patients were treated for upper extremity complications due to therapeutic agents. Forty-nine injuries were associated with chemotherapy and 62 with so-called "non-toxic" solutions. Twenty-five required debridement and skin coverage operations, and six required emergency fasciotomies. The most effective regimen included immediately stopping the intravenous line, elevation, avoidance of antidotes, late debridement and coverage, and early rehabilitation. JF - The Journal of hand surgery AU - Seyfer, A E AD - Division of Plastic and Reconstructive Surgery, Uniformed Services University of the Health Sciences. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 744 EP - 750 VL - 12 IS - 5 Pt 1 SN - 0363-5023, 0363-5023 KW - Index Medicus KW - Osmolar Concentration KW - Humans KW - Hydrogen-Ion Concentration KW - Aged KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Fasciotomy KW - Child, Preschool KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Debridement KW - Adolescent KW - Female KW - Male KW - Hand -- drug effects KW - Drug-Related Side Effects and Adverse Reactions KW - Forearm -- drug effects KW - Hand -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81023497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+hand+surgery&rft.atitle=Upper+extremity+injuries+due+to+medications.&rft.au=Seyfer%2C+A+E&rft.aulast=Seyfer&rft.aufirst=A&rft.date=1987-09-01&rft.volume=12&rft.issue=5+Pt+1&rft.spage=744&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+hand+surgery&rft.issn=03635023&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-20 N1 - Date created - 1987-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - The house-frequenting, host-seeking and resting behavior of Anopheles darlingi in southeastern Amazonas, Brazil. AN - 78063400; 3504928 AB - Studies on the behavior of Anopheles darlingi were conducted at a site along the Ituxi River, Amazonas, Brazil. Patterns of host-seeking activity inside and outside a single-walled house both presented activity peaks at sunset and sunrise, but biting activity inside a four-walled house peaked after sunset then gradually decreased during the night. Major movements of females into and out of the four-walled house occurred at sunset and sunrise, respectively. Marked engorged and unengorged females released indoors were observed to preferentially rest on the ceiling. These behavior patterns were confirmed by replication and/or with more than one sampling technique or study method. Additional observations on exit sites, spatial distribution of resting females and physiological condition of exiting specimens were recorded. JF - Journal of the American Mosquito Control Association AU - Roberts, D R AU - Alecrim, W D AU - Tavares, A M AU - Radke, M G AD - Department of Preventive Medicine/Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 433 EP - 441 VL - 3 IS - 3 SN - 8756-971X, 8756-971X KW - Index Medicus KW - Ecology KW - Demography KW - Animals KW - Housing KW - Humans KW - Brazil KW - Temperature KW - Time Factors KW - Insect Bites and Stings -- epidemiology KW - Female KW - Anopheles -- physiology KW - Behavior, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78063400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Mosquito+Control+Association&rft.atitle=The+house-frequenting%2C+host-seeking+and+resting+behavior+of+Anopheles+darlingi+in+southeastern+Amazonas%2C+Brazil.&rft.au=Roberts%2C+D+R%3BAlecrim%2C+W+D%3BTavares%2C+A+M%3BRadke%2C+M+G&rft.aulast=Roberts&rft.aufirst=D&rft.date=1987-09-01&rft.volume=3&rft.issue=3&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Mosquito+Control+Association&rft.issn=8756971X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-27 N1 - Date created - 1989-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Determinants of Military Expenditures in Developing Countries AN - 61596298; 198801462 AB - It is argued that though Wagner's Law (references omitted in journal) provides useful insights into the relationship between per capita income & defense expenditures, it does not account for other influential factors. A cross-sectional analysis is offered of how patterns of military spending in developing countries are affected by revenue constraint & external sources of funding. A discriminant analysis is conducted to place a sample of 96 countries into 2 groups on the basis of differences in their gross domestic resources & dependence on external debt/capital flows, using data from the World Bank, International Monetary Fund, Yale Data Base on Political & Social Indicators, & the US Arms Control & Disarmament Agency for 1970-1982. Results of factor & regression analyses reveal the economic variables most responsible for differences in military spending between the two groups: share of military expenditure in total government budget, gross domestic product, public external debt, & gross national product per capita. Results suggest that military expenditures in developing countries are affected by a set of factors common to specific groups of countries rather than to developing countries as a whole. K. Hyatt JF - Arms Control AU - Looney, Robert E AD - US Naval Postgraduate School, Monterey CA 93943 Y1 - 1987/09// PY - 1987 DA - September 1987 SP - 195 EP - 207 VL - 8 IS - 2 SN - 0144-0381, 0144-0381 KW - defense expenditures, developing countries KW - economic factors KW - official data KW - Expenditures KW - Economic Factors KW - Developing Countries KW - National Security KW - article KW - 8309: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61596298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arms+Control&rft.atitle=Determinants+of+Military+Expenditures+in+Developing+Countries&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1987-09-01&rft.volume=8&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Arms+Control&rft.issn=01440381&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Developing Countries; National Security; Economic Factors; Expenditures ER - TY - JOUR T1 - American Strategic Deception in the Pacific: 1942-44 AN - 61016113; 88T7483 AB - A discussion of US deception in the Pacific in WWII & its strategic impact. Although Japan has been credited with considerable deception ability as exemplified by the attack on Pearl Harbor, the US, not Japan, had the more sophisticated capability for deception in the Pacific war. The development of this strategy is traced, & detailed examples are presented & analyzed for the 1942-1944 period. Organizational struggles that paralleled the strategic use of deception efforts are evaluated. F. Rasmussen JF - Intelligence and National Security AU - Herbig, Katherine L AD - US Naval Postgraduate School, Monterey CA 93943 Y1 - 1987/07// PY - 1987 DA - July 1987 SP - 260 EP - 300 VL - 2 IS - 3 SN - 0268-4527, 0268-4527 KW - use of deception, US vs Japan, WWII KW - Geopolitics KW - Deception KW - United States of America KW - World War II KW - Japan KW - article KW - 0623: complex organization; military sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61016113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intelligence+and+National+Security&rft.atitle=American+Strategic+Deception+in+the+Pacific%3A+1942-44&rft.au=Herbig%2C+Katherine+L&rft.aulast=Herbig&rft.aufirst=Katherine&rft.date=1987-07-01&rft.volume=2&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Intelligence+and+National+Security&rft.issn=02684527&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - INNSEW N1 - SubjectsTermNotLitGenreText - United States of America; Japan; Deception; World War II; Geopolitics ER - TY - JOUR T1 - The Varied Faces of Domination: State Terror, Economic Policy, and Social Rupture during the Argentine "Proceso," 1976-81 AN - 61012415; 88T6820 AB - An exploration of the varied usage of state terror as a complement to a specific economic project under the military-bureaucratic authoritarian regime that governed Argentina between 1976 & 1981. To do so, a neo-Gramscian theoretical approach is adopted in order to demonstrate that state terror was an essential part of the exercise in domination that was the so-called Proceso de Reorganizacion Nacional (Process of National Reorganization). It is demonstrated that both overt & more subtle forms of state terror were used by the military regime & its civilian allies in a systematic attempt to disrupt the economic & political strength of those believed responsible for the chaotic social conditions they inherited: the domestic bourgeoisie & organized Wcs. An appraisal is made of the impact this application of state terror had on collective identities within the victimized classes, as well as on Argentine society as a whole. 89 References. HA JF - American Journal of Political Science AU - Buchanan, Paul G AD - US Naval Postgraduate School, Monterey CA 93940 Y1 - 1987/05// PY - 1987 DA - May 1987 SP - 336 EP - 382 VL - 31 IS - 2 SN - 0092-5853, 0092-5853 KW - state terror, political/economic applications, Argentina, 1976-1981 KW - Political Violence KW - Political Systems KW - Terrorism KW - Argentina KW - Economic Policy KW - article KW - 2884: studies in violence; terrorism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61012415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Political+Science&rft.atitle=The+Varied+Faces+of+Domination%3A+State+Terror%2C+Economic+Policy%2C+and+Social+Rupture+during+the+Argentine+%22Proceso%2C%22+1976-81&rft.au=Buchanan%2C+Paul+G&rft.aulast=Buchanan&rft.aufirst=Paul&rft.date=1987-05-01&rft.volume=31&rft.issue=2&rft.spage=336&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Political+Science&rft.issn=00925853&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPLB4 N1 - SubjectsTermNotLitGenreText - Argentina; Political Violence; Political Systems; Economic Policy; Terrorism ER - TY - JOUR T1 - Mechanism of Mexican Economic Growth: The Role of Deteriorating Sources of Growth in the Current Economic Crisis AN - 61585965; 198801461 AB - An alternative explanation for the current economic problems in Mexico that stresses the longer-run trends in declining total factor productivity experienced by the economy since WWII. Calculations of the factors underlying the slow-down in Mexican economic growth are presented. Changes in the rate of growth of productivity are attributed to: (1) inappropriateness of the input mix, (2) inappropriateness of the output composition, (3) declining competition, & (4) rapid increases in the number of workers entering the LF. 4 Tables. F. Rasmussen JF - Journal of Social, Political and Economic Studies AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93943 Y1 - 1987/04// PY - 1987 DA - April 1987 SP - 77 EP - 94 VL - 12 IS - 1 SN - 0193-5941, 0193-5941 KW - economic slow-down, Mexico, alternative explanation KW - Depression (Economics) KW - Mexico KW - Economic Development KW - article KW - 8370: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61585965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social%2C+Political+and+Economic+Studies&rft.atitle=Mechanism+of+Mexican+Economic+Growth%3A+The+Role+of+Deteriorating+Sources+of+Growth+in+the+Current+Economic+Crisis&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1987-04-01&rft.volume=12&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social%2C+Political+and+Economic+Studies&rft.issn=01935941&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mexico; Economic Development; Depression (Economics) ER - TY - JOUR T1 - Military Expenditure in Third World Countries: The Economic Effects AN - 61435209; 198803083 JF - Journal of Developing Areas AU - Looney, Robert AU - Looney, Robert AD - Naval Postgraduate School Y1 - 1987/04// PY - 1987 DA - April 1987 SP - 348 EP - 350 VL - 21 IS - 3 SN - 0022-037X, 0022-037X KW - article KW - 8370: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61435209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+Developing+Areas&rft.atitle=Military+Expenditure+in+Third+World+Countries%3A+The+Economic+Effects&rft.au=Looney%2C+Robert%3BDeger%2C+Saadet&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1987-04-01&rft.volume=21&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Journal+of+Developing+Areas&rft.issn=0022037X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - SuppNotes - Edition date: 1986. N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Tropical and Monsoonal Studies AN - 19064924; 8902968 AB - Large-scale motions in the tropics and subtropics particularly those associated with the Asian monsoon circulations were studied. Four areas were investigated: (1) Theoretical studies of planetary scale motion forced by tropical heating - the effects of vertical shear, vertical differential damping and planetary boundary layer were found to influence the forcing of midlatitude motions by tropical heat sources. In addition, the vertical interaction of simple modes may be responsible for the maintenance of the eastward propagating 30-50 day oscillations; (2) Observational studies of planetary scale motions - The day to day variation of the East Asian Jet was found to correlate positively with that of the tropical divergent flow south of it, suggesting the importance of tropical forcing through the local Hadley cell. The transient forcing of time-mean planetary scale circulation was also studied using a nine-year data set; (3) Theoretical studies of zonal asymmetry - several differences between parallel flow and non-parallel flow instabilities in terms of spatial and time growth rates were found using the two-scale technique; and (4) Studies of the Mei-Yu system of the East Asian summer monsoon - A numerical experiment suggested that the Low-Level Jet associated with intense Mei-Yu front receives energy through an equatorward, convection-driven secondary circulation which is quite different from the cross-frontal circulation associated with dry fronts. (Author 's abstract) JF - Available from the National Technical Information Service, Springfield VA 22161, as AD-A188 287. Price codes: A06 in paper copy, A01 in microfiche. Final Technical Report for period June 1984-November 1987, January 1988. 169p. NSF Grant ATM-83-15175. AU - Chang, C P AU - Williams, R T AD - Naval Postgraduate School Monterey, CA Y1 - 1987/04// PY - 1987 DA - Apr 1987 KW - Water Resources Abstracts KW - Climatology KW - Meteorology KW - Tropical regions KW - Monsoons KW - Tropical cyclones KW - Precipitation KW - Wind KW - Shear KW - Convection KW - Storms KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19064924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Tropical+and+Monsoonal+Studies&rft.au=Chang%2C+C+P%3BWilliams%2C+R+T&rft.aulast=Chang&rft.aufirst=C&rft.date=1987-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Effects of Rainfall on the Seasonal Thermocline AN - 19031003; 8807778 AB - An oceanic planetary boundary layer model was used to determine the effects of fresh water flux on the seasonal pycnocline and mixed layer at Ocean Station ' P ' (50 N, 145 W). First sensitivity of the model was tested by constant forcing with a range of values of precipitation minus evaporation. Then realistic forcing with daily average evaporation, monthly average precipitation values, observed winds and heat fluxes were applied to the model for a simulation of the year 1967. The sensitivity study revealed that precipitation and evaporation have a significant impact on the seasonal evolution of mixed layer depth and temperature, even though the surface heat flux is not changed. The use of realistic forcing indicates the importance of having realistic initial salinity profiles in such models. This is especially true in the autumn and winter seasons when rainfall reduces seasonal mixed layer deepening by as much as 25 meters, representing a 20% change. For the simulation of the year 1967, the model predicted values of salinity very closely follow climatology for the first half of the year. During the late summer and fall, predicted salinity is greater than suggested by the climatology and may be due to unrealistically steady values of precipitation. (Author 's abstract) JF - Available from the National Technical Information Service, Springfield VA. 22161, as AD-A184-432. Price codes: A04 in paper copy, A01 in microfiche. Thesis Submitted for Partial Fulfillment of the Requirements for the Degree of Master of Science in Meteorology and Oceanography, June 1987. 69 p, 24 fig, 1 tab, 14 ref. AU - Garzon, G H AD - Naval Postgraduate School Monterey, CA Y1 - 1987/04// PY - 1987 DA - Apr 1987 KW - Water Resources Abstracts KW - Rainfall KW - Thermocline KW - Oceanography KW - Salinity KW - Thermal stratification KW - Mixing KW - Temperature KW - Precipitation KW - Marine environment KW - Simulation analysis KW - Model studies KW - Seasonal variation KW - SW 0890:Estuaries KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19031003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Effects+of+Rainfall+on+the+Seasonal+Thermocline&rft.au=Garzon%2C+G+H&rft.aulast=Garzon&rft.aufirst=G&rft.date=1987-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Consistency and plausibility in epidemiologic analysis: application to breast cancer in relation to use of oral contraceptives. AN - 81028759; 3654903 AB - Consistency and plausibility are fundamental criteria for judging cause and effect from observational studies. They are applied here to the interpretation of data from a population-based case-control study of oral contraceptives and breast cancer. A preliminary analysis of oral contraceptive use in young nulliparous women, who had no family history of either breast cancer or benign breast disease, showed a statistically significant dose-response, with long-term users (49 months or more) having an apparent 4-fold elevation in risk of early breast cancer. Further analyses, however, revealed striking inconsistencies which were biologically implausible. These effectively undermine cause and effect as an explanation for the initial finding. JF - Journal of chronic diseases AU - Schlesselman, J J AU - Stadel, B V AU - Murray, P AU - Wingo, P A AU - Rubin, G L AD - Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Y1 - 1987 PY - 1987 DA - 1987 SP - 1033 EP - 1039 VL - 40 IS - 11 SN - 0021-9681, 0021-9681 KW - Contraceptives, Oral KW - 0 KW - Index Medicus KW - Parity KW - Age Factors KW - Epidemiologic Methods KW - Dose-Response Relationship, Drug KW - Risk Factors KW - Humans KW - Adult KW - Menarche KW - Smoking -- adverse effects KW - Middle Aged KW - Time Factors KW - Female KW - Contraceptives, Oral -- adverse effects KW - Contraceptives, Oral -- administration & dosage KW - Breast Neoplasms -- epidemiology KW - Breast Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81028759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chronic+diseases&rft.atitle=Consistency+and+plausibility+in+epidemiologic+analysis%3A+application+to+breast+cancer+in+relation+to+use+of+oral+contraceptives.&rft.au=Schlesselman%2C+J+J%3BStadel%2C+B+V%3BMurray%2C+P%3BWingo%2C+P+A%3BRubin%2C+G+L&rft.aulast=Schlesselman&rft.aufirst=J&rft.date=1987-01-01&rft.volume=40&rft.issue=11&rft.spage=1033&rft.isbn=&rft.btitle=&rft.title=Journal+of+chronic+diseases&rft.issn=00219681&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-11-02 N1 - Date created - 1987-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - Defense Expenditures, External Public Debt and Growth in Developing Countries AN - 61551616; 198801463 AB - Following a review of the literature, the relationship between growth & defense spending in developing countries is reexamined using a model that recognizes differences in the borrowing capacity of individual countries. Official statistics are used to test the hypothesis that a negative relationship exists between defense & economic growth in countries that are financially resource constrained, & a positive relationship exists in countries that are relatively resource unconstrained. Factor & discriminate analysis are used to group countries based on 33 government & financing variables that depict a country's external debt, structural condition, growth, & balance of payments position between 1970 & 1982. Regression equations are estimated for the total sample & each group, with the growth in gross domestic product as the dependent variable. Results confirm the hypothesized positive relationship between defense & growth in the unconstrained group, & suggest the importance of variables such as foreign exchange, net inflows of capital, external debt, & the growth of the public sector in general on economic grouth. 2 Tables, 1 Appendix, 31 References. Modified HA JF - Journal of Peace Research AU - Looney, Robert E AU - Frederiksen, P C AD - US Naval Postgraduate School, Monterey CA 93940 Y1 - 1986/12// PY - 1986 DA - December 1986 SP - 329 EP - 338 VL - 23 IS - 4 SN - 0022-3433, 0022-3433 KW - economic growth-defense spending relationship, developing countries KW - resource constraint KW - US/international statistics KW - 1970-1982 KW - Fiscal Policy KW - Resource Allocation KW - Economic Development KW - Developing Countries KW - article KW - 8370: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61551616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Peace+Research&rft.atitle=Defense+Expenditures%2C+External+Public+Debt+and+Growth+in+Developing+Countries&rft.au=Looney%2C+Robert+E%3BFrederiksen%2C+P+C&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1986-12-01&rft.volume=23&rft.issue=4&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Journal+of+Peace+Research&rft.issn=00223433&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Developing Countries; Economic Development; Resource Allocation; Fiscal Policy ER - TY - JOUR T1 - Austerity and Military Expenditures in Developing Countries: The Case of Venezuela AN - 61438888; 198701304 AB - In times of economic austerity, governments faced with declining revenues & political restraints on increasing taxes must resort to major budgetary cutbacks. However, relatively little is known about how the governments of developing countries make expenditure decisions, or how they trade off between consumption & investment or between functional categories of expenditures. Some sectors are often thought to be more vulnerable than others to reductions; eg, social sectors are usually considered more & defense sectors less susceptible. An analysis of Venezuelan military expenditures over 1950-1983 confirms that a high level of stability exists in the country's pattern of defense expenditures & that during the current period of austerity, defense expenditures are likely to be cut back less than other functional expenditures such as health, education, & economic development. 2 Tables, 8 References. HA JF - Socio-Economic Planning Sciences AU - Looney, Robert E AD - National Security Affairs Naval Postgraduate School, Monterey CA 93943 Y1 - 1986///0, PY - 1986 DA - 0, 1986 SP - 161 EP - 164 VL - 20 IS - 3 SN - 0038-0121, 0038-0121 KW - governmental budgetary decisions, military vs social programs, developing countries KW - case study KW - Venezuela KW - 1950-1983 KW - Expenditures KW - Militarism KW - Economic Crises KW - article KW - 8370: social development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61438888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Socio-Economic+Planning+Sciences&rft.atitle=Austerity+and+Military+Expenditures+in+Developing+Countries%3A+The+Case+of+Venezuela&rft.au=Looney%2C+Robert+E&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1986-01-01&rft.volume=20&rft.issue=3&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Socio-Economic+Planning+Sciences&rft.issn=00380121&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Militarism; Expenditures; Venezuela; Economic Crises ER - TY - JOUR T1 - Finite element modelling of nonlinear coastal currents AN - 13810634; S198720369 AB - Coastal management is essential for shoreline protection and for the conservation of the coastal environment. The particular problem of coastal sediment transport, which is of concern to the ocean industry, requires understanding of the dynamics of nearshore waves and currents and especially the accurate prediction of wave-induced currents. The theoretical formulations of the problem of nearshore currents are reviewed and previously developed time-averaged and depth-integrated equations and numerical models are outlined. A numerical model of wave-induced mean sea level variations and coastal currents in the nearshore region was developed by the finite element method and included nonlinear convective accelerations, lateral mixing and bottom friction. A wave model was also developed with a semi-discrete Galerkin method to specify the wave refraction field. The numerical accuracy of the model was verified with the analytic solutions for one dimensional longshore currents and two dimensional rip currents, and the model was also applied to predict realistic meandering currents occurring on a periodic rip channel. The limitations of the model were that it ignored wave-current interaction and did not consider coastal structures which would radiate the wave field. JF - Journal of Waterway, Port, Coastal and Ocean Engineering AU - Wu, C S AD - Naval Postgraduate School, Monterey, Calif. Y1 - 1985 PY - 1985 DA - 1985 SP - 417 EP - 432 VL - 111 IS - 2 SN - 0733-950X, 0733-950X KW - Analysis KW - Galerkin formulation KW - Modelling (-general-) KW - Sea water (see also marine -----) KW - Aqualine Abstracts KW - AQ 00001:Water Resources and Supplies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13810634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Waterway%2C+Port%2C+Coastal+and+Ocean+Engineering&rft.atitle=Finite+element+modelling+of+nonlinear+coastal+currents&rft.au=Wu%2C+C+S&rft.aulast=Wu&rft.aufirst=C&rft.date=1985-01-01&rft.volume=111&rft.issue=2&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Journal+of+Waterway%2C+Port%2C+Coastal+and+Ocean+Engineering&rft.issn=0733950X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Some simple models for continuous variate time series AN - 13808484; S198721620 AB - Recent models for continuous variate non-Gaussian time series are reviewed, with particular reference to marginally specific models with given correlation structure. Exponential, Gamma, Weibull, Laplace, Beta, and Mixed Exponential models are considered for the marginal distribution of the stationary time series. Most were random coefficient, additive linear models. The meanings of autoregression and linearity are discussed. A bibliography of 54 references is appended. JF - Water Resources Bulletin AU - Lewis, PAW AD - Naval Postgraduate School, Monterey, Calif. Y1 - 1985 PY - 1985 DA - 1985 SP - 635 EP - 644 VL - 21 IS - 4 SN - 0043-1370, 0043-1370 KW - Modelling (-general-) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13808484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Bulletin&rft.atitle=Some+simple+models+for+continuous+variate+time+series&rft.au=Lewis%2C+PAW&rft.aulast=Lewis&rft.aufirst=PAW&rft.date=1985-01-01&rft.volume=21&rft.issue=4&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Bulletin&rft.issn=00431370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - CPAPER T1 - Organizational Openness and Personal Autonomy: Basic Issues for Society T2 - American Sociological Association AN - 61724784; 84S16489 AB - Systems thinking provides the scientific basis for a holistic approach to the study of human social behavior, & for development of the Open Systems Model for studing organizations. Buckminster Fuller's conception of man as "transceiver" vividly conveys the view of humans as the "middle men" of the universe -- both receiving & transmitting signals, modeling on patterns they perceive to create new technologies & forms. Such an active, self-empowered being is ill-suited to a closed bureaucratic environment. An open organizational environment may be conducive to increased personal autonomy in workers & clients of the system. A pilot study of 6 community Colls in Tex using this Open Systems Model showed a positive relationship between organizational context & individual autonomy. An Institutional Openness Index was developed to rank the Colls & place them in 3 categories: most open, relatively open, & relatively closed. Autonomy was measured by pre- & posttesting 633 students on the Adult Nowicki-Strickland Internal-External Locus of Control Scale in the fall of 1975 & spring of 1976. Analysis of variance & covariance revealed a clear relationship between internality of students & institutional openness. The data also show a trend for students to change more toward internality in the more open settings. JF - American Sociological Association AU - Goldman, Kathryn L Y1 - 1984///0, PY - 1984 DA - 0, 1984 KW - organizational behavior KW - Open Systems Model KW - Texas community college pilot study KW - System/Systems KW - Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing KW - proceeding KW - 0624: complex organizations; bureaucratic structures/organizational sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61724784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=American+Sociological+Association&rft.atitle=Organizational+Openness+and+Personal+Autonomy%3A+Basic+Issues+for+Society&rft.au=Goldman%2C+Kathryn+L&rft.aulast=Goldman&rft.aufirst=Kathryn&rft.date=1984-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2012-05-01 N1 - Publication note - 1984 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Stress Management: The Importance of Organizational Context AN - 61044791; 85Q0993 AB - The role of clinical sociologists in stress management programs, usually dominated by professionals trained in individual psychodynamics, is explored. Personal experience in two such programs, conducted in a large state hospital & in a small, private business, is reviewed. Differences in the organizational characteristics of the two settings appear to account for the substantially greater success experienced in the business setting. Awareness of context is a contribution clinical sociologists can make to further programs of this type. 7 References. W. H. Stoddard. JF - Clinical Sociology Review AU - Goldman, Kathryn L AD - Naval Postgraduate School, Monterey CA 93940 Y1 - 1984///0, PY - 1984 DA - 0, 1984 SP - 133 EP - 136 VL - 2 SN - 0730-840X, 0730-840X KW - stress management, clinical sociological role, social context KW - personal experience KW - Stress/Stresses KW - Clinical sociology KW - article KW - 3166: clinical sociology; clinical sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61044791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Sociology+Review&rft.atitle=Stress+Management%3A+The+Importance+of+Organizational+Context&rft.au=Goldman%2C+Kathryn+L&rft.aulast=Goldman&rft.aufirst=Kathryn&rft.date=1984-01-01&rft.volume=2&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Clinical+Sociology+Review&rft.issn=0730840X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - CSRVDT N1 - SubjectsTermNotLitGenreText - Stress/Stresses; Clinical sociology ER - TY - JOUR T1 - Who's Talking about the Future? An Analysis of U.S. Presidents AN - 1761717907; 198500651 AB - The degree of consciousness of the future & the implications of differing views of it were analyzed in a linguistic analysis of 13 inaugural addresses of US presidents since 1933. The future is described as an "irreality," since it does not yet exist, & as a construct of human thought. The language used to describe the future, which is determined by the way in which people collectively think about it, can be useful in understanding forecasting & planning. Although the future can be conveyed in all different world classes, the use of nine primary modals (ie, will, can, may, shall, would, could, might, should, & must) measured future talk found in the inaugural addresses far more than everyday or history-talk English. The future is being discussed when the rate of modal usage is more than 2% of all the words used. According to the rate of modal usage, Truman, Johnson, & Reagan have been the most future conscious presidents, & Eisenhower the least. The division of modals into three types showed different ways of thinking about the future: the "event contingency" mode was characterized by Johnson; the "event causation" mode was characterized by Kennedy & Roosevelt; & a "disposition to satisfy obligations" mode was characterized by Eisenhower & Truman. This type of analysis can be used to compare presidents (eg, Reagan's style of thought & modal usage is most similar to that of Truman) & consequently forecast their performance with some additional correlations. 6 Tables, 3 Figures, 2 Appendixes, 21 References. Modified HA. JF - Technological Forecasting and Social Change AU - Evered, Roger AD - Naval Postgraduate School, Monterey CA 93940 Y1 - 1983/09// PY - 1983 DA - September 1983 SP - 61 EP - 77 VL - 24 IS - 1 SN - 0040-1625, 0040-1625 KW - US presidents' future consciousness/attitudes KW - linguistic analysis KW - inaugural addresses 1933-1983 KW - Future/Futurism/Futurist/ Futurologist/ Futurologists KW - United States/US KW - Presidency/Presidential/President KW - article KW - 7210: social policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761717907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technological+Forecasting+and+Social+Change&rft.atitle=Who%27s+Talking+about+the+Future%3F+An+Analysis+of+U.S.+Presidents&rft.au=Evered%2C+Roger&rft.aulast=Evered&rft.aufirst=Roger&rft.date=1983-09-01&rft.volume=24&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Technological+Forecasting+and+Social+Change&rft.issn=00401625&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States/US; Presidency/Presidential/President; Future/Futurism/Futurist/ Futurologist/ Futurologists ER - TY - JOUR T1 - Defense Expenditures and Economic Growth in Developing Countries AN - 1761721089; 198500755 AB - A reexamination of the effect of defense spending on economic growth in developing countries. Emile Benoit found this effect to be statistically insignificant for a sample of 44 countries between 1950 & 1965 (see SA 27:3/79J9984). It is hypothesized here that the effect of defense spending should be positive & statistically significant for relatively resource-abundant countries but negative for relatively poorer countries. Using Benoit's data & sample, the countries were split into 2 groups using a cluster analysis. The regression equation estimated by Benoit was reestimated for each group. The results support the hypothesis that the richer countries are less likely to abandon development expenditures given a constant level of defense preparedness. The poorer countries, unable to afford defense & growth expenditures, prefer to cut the latter while maintaining the former. 2 Tables. Modified AA. JF - Armed Forces and Society AU - Frederiksen, P C AU - Looney, Robert E AD - Naval Postgraduate School, Monterey CA 93940 Y1 - 1983/07// PY - 1983 DA - July 1983 SP - 633 EP - 645 VL - 9 IS - 4 SN - 0095-327X, 0095-327X KW - economic growth, developing countries KW - defense spending KW - Emile Benoit's multinational statistics KW - 1950-1965 KW - Expenditures KW - Economic/Economics/Economical KW - Growth KW - Defense/Defenses KW - Developing countries KW - article KW - 8309: international issues in social work UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761721089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Armed+Forces+and+Society&rft.atitle=Defense+Expenditures+and+Economic+Growth+in+Developing+Countries&rft.au=Frederiksen%2C+P+C%3BLooney%2C+Robert+E&rft.aulast=Frederiksen&rft.aufirst=P&rft.date=1983-07-01&rft.volume=9&rft.issue=4&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Armed+Forces+and+Society&rft.issn=0095327X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Economic/Economics/Economical; Growth; Developing countries; Defense/Defenses; Expenditures ER - TY - JOUR T1 - AIDS from the perspective of experimental pathology. AN - 80979296; 6100977 JF - Journal of experimental pathology AU - Preble, O T AU - Sonnabend, J A AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. Y1 - 1983 PY - 1983 DA - 1983 SP - 3 EP - 6 VL - 1 IS - 1 SN - 0730-8485, 0730-8485 KW - Antibodies, Viral KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Autoimmune Diseases -- etiology KW - Cytomegalovirus -- immunology KW - Hemophilia A KW - Cytomegalovirus -- isolation & purification KW - Homosexuality KW - Antibodies, Viral -- analysis KW - Haiti KW - Sexual Behavior KW - Opportunistic Infections -- etiology KW - Cytomegalovirus Infections -- complications KW - Substance-Related Disorders KW - HIV KW - Herpesvirus 4, Human -- immunology KW - T-Lymphocytes -- immunology KW - Male KW - Sarcoma, Kaposi -- etiology KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Acquired Immunodeficiency Syndrome -- immunology KW - Acquired Immunodeficiency Syndrome -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80979296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+pathology&rft.atitle=AIDS+from+the+perspective+of+experimental+pathology.&rft.au=Preble%2C+O+T%3BSonnabend%2C+J+A&rft.aulast=Preble&rft.aufirst=O&rft.date=1983-01-01&rft.volume=1&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+pathology&rft.issn=07308485&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-14 N1 - Date created - 1988-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-17 ER - TY - JOUR T1 - A Programmed Approach toward a Regional Expenditure Policy for Mexico AN - 1761719852; 198501328 AB - The economic problems of Mexico, evidenced by rapid population growth, poverty, & inequality, are examined. In spite of efforts by the Mexican government to reverse this trend, the problems are increasing, probably as a result of a burgeoning bureaucracy, lack of interdepartmental coordination, & lack of empirical data to guide planning. It is argued that decision making & investment are the keys to maximizing economic development. To date, the government has been effective only in the central triangle of Mexico. The 1979 National Plan for Industrial Development, making use of oil revenues, has failed to redress the imbalance. Here, a thesis on regional expenditure put forward by Niles Hansen is tested ("Unbalanced Growth and Regional Development," Western Economic Journal, 1965, 4, Sept, 3-14). Hansen argues that in developed areas, investment should be in the realm of economic overhead capital (roads, harbors, etc); in underdeveloped areas, it should be in that of social overhead capital (schools, hospitals, etc). Cluster analysis of two geographical regions & regression analysis of the infrastructure lend strong support for Hansen's views. The policy implications for planning & expenditure are discussed in light of these findings. 2 Tables. J. Peterson. JF - Journal of Developing Areas AU - Looney, Robert E AU - Frederiksen, Peter C AD - Naval Postgraduate School, Monterey CA 93940 Y1 - 1982/10// PY - 1982 DA - October 1982 SP - 1 EP - 12 VL - 17 IS - 1 SN - 0022-037X, 0022-037X KW - Mexico's economic problems, decision-making/investment strategies, Niles Hansen's regional expenditure thesis tested KW - Economic/Economics/Economical KW - Invest/Invested/Investment/ Investor/ Investors KW - Mexico/Mexican/Mexicans KW - Decision-making KW - article KW - 7210: social policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761719852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Developing+Areas&rft.atitle=A+Programmed+Approach+toward+a+Regional+Expenditure+Policy+for+Mexico&rft.au=Looney%2C+Robert+E%3BFrederiksen%2C+Peter+C&rft.aulast=Looney&rft.aufirst=Robert&rft.date=1982-10-01&rft.volume=17&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Developing+Areas&rft.issn=0022037X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mexico/Mexican/Mexicans; Economic/Economics/Economical; Decision-making; Invest/Invested/Investment/ Investor/ Investors ER - TY - JOUR T1 - The effect of methylazoxymethanol acetate (MAM) on the developing rat retina. AN - 15555361; 407881 AB - The morphological effects of methylazoxymethanol acetate (MAM) on the prenatal and postnatal rat retina were studied using light and electron microscopy. The retina from adult animals treated with MAM between days E17 and PE5 appeared normal. The developing rat retina in sensitive to MAM during gestation and the early postnatal period. JF - Experimental Eye Research AU - Latker, CH AU - Eiden, LE AU - Zatz, M AD - Dep. Anato., USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 351 EP - 361 VL - 35 IS - 4 SN - 0014-4835, 0014-4835 KW - effects on KW - rats KW - methylazoxymethanol acetate KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - morphogenesis KW - retina KW - X 24172:Plants KW - N3 11094:Central nervous system UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15555361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Eye+Research&rft.atitle=The+effect+of+methylazoxymethanol+acetate+%28MAM%29+on+the+developing+rat+retina.&rft.au=Latker%2C+CH%3BEiden%2C+LE%3BZatz%2C+M&rft.aulast=Latker&rft.aufirst=CH&rft.date=1982-01-01&rft.volume=35&rft.issue=4&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Experimental+Eye+Research&rft.issn=00144835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - morphogenesis; retina ER - TY - JOUR T1 - Reproductive gambling in bighorn sheep (Ovis ): A stimulation. AN - 15547605; 418725 AB - It has been hypothesized that bighorn sheep living in unpredictable desert environments may resort to a life history pattern of reproductive gambling in which they have increased fertility because of continuous breeding. To determine whether such gambling is in fact feasible, simulations of a seasonal and gambling population were run with survival schedules generated as functions of precipitation. Although annual per capita fertility was substantially increased in the gambling population, the seasonal strategy resulted in a higher finite rate of increase. These results indicate that reproductive gambling, as modeled, is not an ecologically stable strategy unless survival of offspring born outside the optimum period is substantially increased. JF - Journal of Theoretical Biology AU - Lenarz AU - Conley, W AD - NPS Co-Operative Res. Unit, Inst. Ecol., Univ. Georgia, Athens, GA 30602, USA Y1 - 1982 PY - 1982 DA - 1982 SP - 1 EP - 7 VL - 98 IS - 1 SN - 0022-5193, 0022-5193 KW - deserts KW - Ecology Abstracts KW - reproductive strategy KW - life history KW - Ovis KW - D 04672:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15547605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Theoretical+Biology&rft.atitle=Reproductive+gambling+in+bighorn+sheep+%28Ovis+%29%3A+A+stimulation.&rft.au=Lenarz%3BConley%2C+W&rft.aulast=Lenarz&rft.aufirst=&rft.date=1982-01-01&rft.volume=98&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Theoretical+Biology&rft.issn=00225193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - Ovis; life history; reproductive strategy ER - TY - JOUR T1 - A Cultural Perspective on Organizations: The Need for and Consequences of Viewing Organizations as Culture-Bearing Milieus AN - 61033421; 85O8083 AB - The prevalence & influence of cultural phenomena in organizations coupled with limitations inherent in traditional approaches to organizational inquiry suggest the need to add a cultural perspective (CP). Such a perspective is proposed to guide inquiry on intersubjective, emergent, context-embedded, &/or interpretive phenomena in organizational settings. The CP represents a social definition paradigm that contrasts with the social fact paradigm of traditional perspectives. Methodological consequences of a CP are discussed, relevant topics of study illustrated, & methods of organizational inquiry reflective of a CP outlined. 2 Tables, 3 Figures, 54 References. Modified HA. JF - Human Systems Management AU - Louis, Meryl Reis AD - Naval Postgraduate School, Monterey CA 93940 Y1 - 1981/12// PY - 1981 DA - December 1981 SP - 246 EP - 258 VL - 2 IS - 4 SN - 0167-2533, 0167-2533 KW - organizational inquiry, cultural perspective, social definition paradigm KW - Culture/Cultures/Cultural/ Culturally KW - Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing KW - article KW - 0624: complex organizations; bureaucratic structures/organizational sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61033421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Systems+Management&rft.atitle=A+Cultural+Perspective+on+Organizations%3A+The+Need+for+and+Consequences+of+Viewing+Organizations+as+Culture-Bearing+Milieus&rft.au=Louis%2C+Meryl+Reis&rft.aulast=Louis&rft.aufirst=Meryl&rft.date=1981-12-01&rft.volume=2&rft.issue=4&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Human+Systems+Management&rft.issn=01672533&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - HSMADU N1 - SubjectsTermNotLitGenreText - Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing; Culture/Cultures/Cultural/ Culturally ER - TY - JOUR T1 - Internalization of ricin in Chinese hamster ovary cells. AN - 73985107; 6965107 AB - Internalization of ricin into Chinese hamster ovary cells has been investigated. Combined treatment with galactose and pronase at 0 degrees C resulted in a complete release of surface-bound [125I]ricin into the media. Galactose-pronase-resistant cell-bound [125I]ricin represents internalized ricin molecules inside the cells. The internalization process is time, temperature, and concentration dependent. The pH optimum of internalization of ricin is about pH 7. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis has revealed that intact ricin molecules are internalized. Neither reduction nor proteolytic processing of ricin is required for the entry of ricin into Chinese hamster ovary cells. JF - Molecular and cellular biology AU - Ray, B AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014. Y1 - 1981/06// PY - 1981 DA - June 1981 SP - 544 EP - 551 VL - 1 IS - 6 SN - 0270-7306, 0270-7306 KW - Receptors, Mitogen KW - 0 KW - Ricin KW - 9009-86-3 KW - Pronase KW - EC 3.4.24.- KW - Galactose KW - X2RN3Q8DNE KW - Index Medicus KW - Animals KW - Receptors, Mitogen -- drug effects KW - Kinetics KW - Receptors, Mitogen -- metabolism KW - Pronase -- pharmacology KW - Galactose -- pharmacology KW - Biological Transport, Active KW - Cell Line KW - Cricetinae KW - Ricin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73985107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Internalization+of+ricin+in+Chinese+hamster+ovary+cells.&rft.au=Ray%2C+B%3BWu%2C+H+C&rft.aulast=Ray&rft.aufirst=B&rft.date=1981-06-01&rft.volume=1&rft.issue=6&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1969 Aug 25;244(16):4406-12 [5806584] Mol Cell Biol. 1981 Jun;1(6):560-7 [6965109] Experientia. 1972 Jan 15;28(1):84-5 [5062493] Eur J Biochem. 1973 May;35(1):179-85 [4123356] J Biol Chem. 1974 Feb 10;249(3):803-10 [4811904] J Biol Chem. 1974 May 25;249(10):3061-7 [4830236] J Biol Chem. 1974 Jun 10;249(11):3557-62 [4208663] Cancer Res. 1975 Jan;35(1):144-55 [162859] Bacteriol Rev. 1975 Mar;39(1):54-85 [164179] Biochim Biophys Acta. 1975 Sep 9;405(1):1-10 [1174560] J Biol Chem. 1976 Jul 10;251(13):3977-84 [6468] FEBS Lett. 1977 Apr 15;76(2):166-72 [862896] Infect Immun. 1977 Apr;16(1):232-9 [141424] Annu Rev Biochem. 1977;46:69-94 [20040] J Biol Chem. 1978 Oct 10;253(19):6866-71 [690129] J Supramol Struct. 1978;9(2):253-68 [748677] Nature. 1979 Jun 21;279(5715):679-85 [221835] Biochem J. 1969 Jun;113(2):299-305 [4185494] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhanced internalization of ricin in nigericin-pretreated Chinese hamster ovary cells. AN - 73980934; 6965109 AB - Biochemical and electron microscopic autoradiographic studies with [125I] ricin have revealed that nigericin-pretreated Chinese hamster ovary cells are more efficient than untreated cells in the internalization of the toxin into the cells. These results suggest that the enhanced rate of internalization of ricin in nigericin-pretreated cells may account for the enhancement of cytotoxicity of ricin in Chinese hamster ovary cells by nigericin. JF - Molecular and cellular biology AU - Ray, B AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014. Y1 - 1981/06// PY - 1981 DA - June 1981 SP - 560 EP - 567 VL - 1 IS - 6 SN - 0270-7306, 0270-7306 KW - Anti-Bacterial Agents KW - 0 KW - Ricin KW - 9009-86-3 KW - Nigericin KW - RRU6GY95IS KW - Index Medicus KW - Biological Transport, Active -- drug effects KW - Animals KW - Kinetics KW - Microscopy, Electron KW - Autoradiography KW - Cell Line KW - Cricetinae KW - Binding Sites KW - Ricin -- metabolism KW - Nigericin -- toxicity KW - Anti-Bacterial Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73980934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Enhanced+internalization+of+ricin+in+nigericin-pretreated+Chinese+hamster+ovary+cells.&rft.au=Ray%2C+B%3BWu%2C+H+C&rft.aulast=Ray&rft.aufirst=B&rft.date=1981-06-01&rft.volume=1&rft.issue=6&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 1971 Aug 3;10(16):3065-9 [5126925] Proc Natl Acad Sci U S A. 1974 Feb;71(2):394-8 [4521810] Cancer Res. 1975 Jan;35(1):144-55 [162859] Biochim Biophys Acta. 1975 Sep 9;405(1):1-10 [1174560] Mol Cell Biol. 1981 Jun;1(6):552-9 [6965108] J Cell Biol. 1977 Jan;72(1):161-73 [63463] Infect Immun. 1977 Apr;16(1):232-9 [141424] J Supramol Struct. 1978;9(2):253-68 [748677] Mol Cell Biol. 1981 Jun;1(6):544-51 [6965107] Exp Cell Res. 1975 Sep;94(2):426-31 [1238268] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhancement of cytotoxicities of ricin and Pseudomonas toxin in Chinese hamster ovary cells by nigericin. AN - 73973354; 6965108 AB - Nigericin and monensin, ionophores for Na+ and K+, have been found to enhance the cytotoxicities of abrin, ricin, and Pseudomonas aeruginosa exotoxin A in Chinese hamster ovary (CHO) cells. They do not affect the cytotoxicity of diphtheria toxin in the same cell line. Maximal sensitization of the CHO cells toward ricin and Pseudomonas toxin requires preculture of CHO cells in the presence of nigericin. Inhibition of protein synthesis in CHO cells by ricin or Pseudomonas toxin is also enhanced by preculture of CHO cells in the presence of nigericin. These results suggest a common step in the intoxication process of ricin and Pseudomonas toxin, the rate of which is facilitated by pretreatment with nigericin. This step is, however, not shared by the intoxication of CHO cells with diphtheria toxin. JF - Molecular and cellular biology AU - Ray, B AU - Wu, H C AD - Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20014. Y1 - 1981/06// PY - 1981 DA - June 1981 SP - 552 EP - 559 VL - 1 IS - 6 SN - 0270-7306, 0270-7306 KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Toxins KW - Cytotoxins KW - Exotoxins KW - Virulence Factors KW - Ricin KW - 9009-86-3 KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Nigericin KW - RRU6GY95IS KW - Index Medicus KW - Animals KW - Cell Survival -- drug effects KW - Drug Synergism KW - Cell Line KW - Cricetinae KW - Ricin -- toxicity KW - Nigericin -- toxicity KW - Exotoxins -- toxicity KW - Anti-Bacterial Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73973354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Enhancement+of+cytotoxicities+of+ricin+and+Pseudomonas+toxin+in+Chinese+hamster+ovary+cells+by+nigericin.&rft.au=Ray%2C+B%3BWu%2C+H+C&rft.aulast=Ray&rft.aufirst=B&rft.date=1981-06-01&rft.volume=1&rft.issue=6&rft.spage=552&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-02-10 N1 - Date created - 1988-02-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 1965 Dec;90(6):1557-62 [5854584] Mol Cell Biol. 1981 Jun;1(6):560-7 [6965109] Eur J Biochem. 1975 Dec 1;60(1):281-8 [1204642] Infect Immun. 1976 Oct;14(4):1077-86 [11187] Proc Natl Acad Sci U S A. 1977 Feb;74(2):472-6 [403520] Infect Immun. 1977 Apr;16(1):232-9 [141424] J Supramol Struct. 1977;6(1):95-101 [895139] Annu Rev Biochem. 1977;46:69-94 [20040] J Exp Med. 1977 Nov 1;146(5):1332-45 [925606] J Supramol Struct. 1978;9(2):253-68 [748677] Proc Natl Acad Sci U S A. 1979 Apr;76(4):1868-72 [377287] Mol Pharmacol. 1979 Jul;16(1):202-14 [384207] J Biol Chem. 1980 Mar 25;255(6):2247-50 [6766935] Proc Natl Acad Sci U S A. 1980 Jun;77(6):3283-7 [6251452] Biochim Biophys Acta. 1975 Sep 9;405(1):1-10 [1174560] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regional Allocation of Water Resources AN - 19208179; 8106168 AB - The Monterey Peninsula Water Management District, a government organization formed to ensure an adequate supply of water for the residents of the Monterey Peninsula, is described. The disrict was formed after the hardship of water rationing occurred during the 1976-77 drought. The district covers about 140 sq mi, and the board is made up of five elected members and two members appointed by the county board of supervisors and a selection committee of member cities. The district has broad powers in the areas of supply, demand, and planning. It controls the sale of water and water rights, the control of floodwaters, and the acquisition of public and private water systems. It has the power to control demand above the present usage rate and below it in times of emergencies. The major problem facing the district in the future is mobilizing public support for the solutions it recommends on the ballot. (Small-FRC) JF - Journal of the American Water works Association Vol. 73, No. 5, p 226-231, May, 1981. 2 Tab, 28 Ref. AU - Smith, W R AD - Naval Postgraduate School Monterey, CA Y1 - 1981/05// PY - 1981 DA - May 1981 KW - Water Resources Abstracts KW - Metropolitan water management KW - Regional planning KW - Water use efficiency KW - Monterey Peninsula KW - California KW - Water districts KW - Water conservation KW - Water resources development KW - SW 1040:Conservation in domestic and municipal use KW - SW 4030:Cost allocation, cost sharing, pricing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19208179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Regional+Allocation+of+Water+Resources&rft.au=Smith%2C+W+R&rft.aulast=Smith&rft.aufirst=W&rft.date=1981-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Mania Associated With LSD Ingestion. AN - 15339701; 169988 AB - The authors report a patient who suffered a full-blown manic attack after ingesting LSD or an LSD analogue. The patient experienced acute symptoms of LSD intoxication, which resolved but were followed in about 3 weeks by a typical manic episode of psychotic magnitude. The mania cleared with lithium therapy. JF - American Journal of Psychiatry AU - Lake, C R AU - Stirba, AL AU - Kinneman, R E AU - Carlson, B AU - Holloway, H C AD - Dept. Psychiatry, USUHS Bldg. B, Rm. 3049, Bethesda, MD 20014, USA Y1 - 1981 PY - 1981 DA - 1981 SP - 1508 EP - 1509 VL - 138 IS - 11 SN - 0002-953X, 0002-953X KW - LSD KW - mania KW - Toxicology Abstracts KW - side effects KW - case reports KW - man KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15339701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Psychiatry&rft.atitle=Mania+Associated+With+LSD+Ingestion.&rft.au=Lake%2C+C+R%3BStirba%2C+AL%3BKinneman%2C+R+E%3BCarlson%2C+B%3BHolloway%2C+H+C&rft.aulast=Lake&rft.aufirst=C&rft.date=1981-01-01&rft.volume=138&rft.issue=11&rft.spage=1508&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-12 N1 - SubjectsTermNotLitGenreText - side effects; man; case reports ER - TY - JOUR T1 - Metabolism of the bay-region trans-1,2-dihydrodiol of benz[a]anthracene in rat liver microsomes occurs primarily at the 3,4-double bond. AN - 75005664; 11219873 AB - The bay-region hydroxyl groups of benz[a]anthracene (+/-)trans-1,2-dihydrodiol are known to be exclusively in quasi-axial conformations. This dihydrodiol was stereoselectively metabolized in rat liver microsomes to form two optically active 1,2,3,4-tetrahydrotetrols as the predominant products. Thus, the bay-region axial hydroxyl groups of benz[a]anthracene trans-1,2-dihydrodiol do not direct metabolism away from the vicinal 3,4-double bond. JF - Carcinogenesis AU - Yang, S K AU - Chou, M W AD - Department of Pharmacology, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20014, USA. Y1 - 1980/09// PY - 1980 DA - September 1980 SP - 803 EP - 806 VL - 1 IS - 9 SN - 0143-3334, 0143-3334 KW - Benz(a)Anthracenes KW - 0 KW - benzanthracene-1,2-dihydrodiol KW - 60839-20-5 KW - Index Medicus KW - Rats KW - Animals KW - Stereoisomerism KW - Molecular Conformation KW - Chromatography, High Pressure Liquid KW - Microsomes, Liver -- metabolism KW - Benz(a)Anthracenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75005664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Metabolism+of+the+bay-region+trans-1%2C2-dihydrodiol+of+benz%5Ba%5Danthracene+in+rat+liver+microsomes+occurs+primarily+at+the+3%2C4-double+bond.&rft.au=Yang%2C+S+K%3BChou%2C+M+W&rft.aulast=Yang&rft.aufirst=S&rft.date=1980-09-01&rft.volume=1&rft.issue=9&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Satellite Observations of a Nutrient Upwelling Off the Coast of California AN - 19207753; 8006499 AB - Satellite thermal imagery was combined with automated chemical analysis of surface waters off central California to detect and better understand a ' nutrient upwelling ' entering the California Current system. While thermal surface water features have been mapped successfully from satellites for a number of years, the relationship of satellite thermal imagery to nutrients, such as nitrates and phosphates, has not been established. As a result of such efforts, satellite remote sensors may help to explain the relationship between chemical mesoscale and pelagic ecosystems of the ocean. Viewed together with the satellite images, the in situ data suggest that nutrient cells may form when a concentrated pulse of upwelled water provides an initial thermochemical mesoscale structure. As a result, sharp gradients or chemical fronts and thermal fronts are formed. It is possible that nutrient cells coincided with thermal eddies observed in earlier satellite images as reasoned when CalCOFI data were compared with infrared images of the California Current system. However, while the correlation of ' satellite temperatures ' with in situ temperatures may hold in all cases, correlations with chemical concentrations will depend on the initial conditions of the source water and subsequent changes that occur as a result of processes of advection, diffusion, mixing, heat transfer, salt transfer, and biological uptake and release of nutrients. (Humphreys-ISWS) JF - Journal of Geophysical Research Vol 85, No C7, p 4101-4106, July 20, 1980. 7 Fig, 11 Ref. ONR 5747, CODE 480. AU - Traganza, ED AU - Nestor, DA AU - McDonald, A K AD - Naval Postgraduate School Monterey, CA. Dept. of Oceanography Y1 - 1980/07// PY - 1980 DA - Jul 1980 KW - Water Resources Abstracts KW - Upwelling KW - Coasts KW - California KW - Remote sensing KW - Nutrients KW - Satellites(Artificial) KW - Mixing KW - Oceans KW - Surface waters KW - Chemical analysis KW - Water quality KW - On-site investigations KW - Phosphates KW - Nitrates KW - Oceanography KW - SW 3020:Sources and fate of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19207753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Satellite+Observations+of+a+Nutrient+Upwelling+Off+the+Coast+of+California&rft.au=Traganza%2C+ED%3BNestor%2C+DA%3BMcDonald%2C+A+K&rft.aulast=Traganza&rft.aufirst=ED&rft.date=1980-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Surprise and Sense Making: What Newcomers Experience in Entering Unfamiliar Organizational Settings AN - 61096253; 81L6774 AB - Growing disillusionment among new members of organizations has been traced to inadequacies in approaches to organizational entry. Current directions of research on organizational entry & their limitations are described, & a new perspective proposed that identifies key features of newcomers' entry experiences, including surprise, contrast, & change. Described are sense-making processes by which individuals cope with entry experiences as well as procedures for easing these processes: discouraging secrecy, encouraging links between newcomers & insiders, & utilizing early appraisal feedback. Newcomers should also be made aware of the nature of entry experiences to facilitate their adaptation to the new situation. Modified HA. JF - Administrative Science Quarterly AU - Louis, Meryl Reis AD - Naval Postgraduate School, Monterey CA 93940 Y1 - 1980/06// PY - 1980 DA - June 1980 SP - 226 EP - 251 VL - 25 IS - 2 SN - 0001-8392, 0001-8392 KW - organizational settings, newcomers' experiences KW - surprise, contrast, change features identified KW - new entry approaches, sense-making processes described KW - Newcomer/Newcomers KW - Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing KW - Experience/Experiences KW - article KW - 0624: complex organizations; bureaucratic structures/organizational sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61096253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administrative+Science+Quarterly&rft.atitle=Surprise+and+Sense+Making%3A+What+Newcomers+Experience+in+Entering+Unfamiliar+Organizational+Settings&rft.au=Louis%2C+Meryl+Reis&rft.aulast=Louis&rft.aufirst=Meryl&rft.date=1980-06-01&rft.volume=25&rft.issue=2&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Administrative+Science+Quarterly&rft.issn=00018392&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ASCQAG N1 - SubjectsTermNotLitGenreText - Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing; Newcomer/Newcomers; Experience/Experiences ER - TY - JOUR T1 - Temperature Fine Structure Near the Sea-Ice Margin of the Chukchi Sea AN - 19179757; 7906739 AB - Temperature fine structure with peak-to-peak fluctuations often exceeding 2C is prevalent throughout the marginal sea-ice zone of the shallow Chukchi Sea in midsummer. It is normally found within 20-35 km outside of the ice and seldom farther than 5-10 km inside the ice margin. It has also been infrequently found more than 100 km south of the ice. Temperature and salinity fronts of all degrees of sharpness occur in the same general area, but the two types need not be coincident. Considerable variability in time and length scales of fine structure elements has been noted with persistences ranging from 2 hours or less to more than 20 hours and length scales ranging from 600 m to more than 20 km. While much of this variability is intrinsic, part can be accounted for by the inability to sample in the direction of flow and the relative motion between the sampling platform and fine structure element. Fine structure lenses are considerably longer parallel to the ice edge, with similarity in temperature structure noted over distances of 80 and 100 km. (Sims-ISWS) JF - Journal of Geophysical Research Vol. 84, No. C3, p 1155-1164, March 20, 1979. 15 fig, 1 tab, 24 ref. N66001-76-PO-00610. AU - Paquette, R G AU - Bourke, R H AD - Naval Postgraduate School Monterey, CA. Dept. of Oceanography Y1 - 1979/03// PY - 1979 DA - Mar 1979 KW - Water Resources Abstracts KW - Water temperature KW - Sea ice KW - Salinity KW - Chukchi Sea KW - Surveys KW - Sampling KW - On-site investigations KW - Ice KW - Melting KW - Oceans KW - Temperature KW - Distribution patterns KW - Temporal distribution KW - Spatial distribution KW - Variability KW - Oceanography KW - SW 0890:Estuaries KW - SW 0820:Snow, ice and frost UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19179757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Temperature+Fine+Structure+Near+the+Sea-Ice+Margin+of+the+Chukchi+Sea&rft.au=Paquette%2C+R+G%3BBourke%2C+R+H&rft.aulast=Paquette&rft.aufirst=R&rft.date=1979-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Fluid Forces on Oscillating Cylinders AN - 19175678; 7812846 AB - The paper presented the results of an experimental and analytical investigation of the forced oscillations of a circular cylinder in uniform flow. The transverse force was decomposed into two components, and the appropriate force-transfer coefficients were determined experimentally through the use of a Fourier averaging technique. The results then were incorporated into the equation of motion to predict the dynamic response of elastically-mounted cylinders. The numerical predictions were found to be in good agreement with those obtained experimentally. The use of the experimentally obtained drag and inertia coefficients for the transverse force together with a numerical integration scheme accurately predicts the dynamic response of a self-excited cylinder in the synchronization region. A parametric study of the separate and combined effects of material damping, mass ratio, and the response parameter showed that the maximum response of the cylinder is governed by the response parameter alone only for S sub G (damping ratio/response parameter) values larger than about unity. Additional data and calculations are needed to explore the effect of these parameters further. It appears, on the basis of somewhat limited observations, that a self-excited system may exhibit unstable oscillations for certain combinations of the damping and mass ratios. (Humphreys-ISWS) JF - Journal of the Waterway, Port, Coastal and Ocean Division, American Society of Civil Engineers Vol. 104, No. WW4, Proceedings Paper 13941, p 275-290, August 1978. 8 fig, 3 tab, 17 ref, 1 append. AU - Sarpkaya, T AD - Naval Postgraduate School Monterey, CA. Dept. of Mechanical Engineering Y1 - 1978/08// PY - 1978 DA - Aug 1978 KW - Water Resources Abstracts KW - Flow resistance KW - Hydraulic structures KW - Laboratory tests KW - Loads(Forces) KW - Fluid mechanics KW - Vibrations KW - Uniform flow KW - Flow KW - Dynamics KW - Theoretical analysis KW - Analysis KW - Drag KW - Methodology KW - Resonance KW - Oscillating cylinders KW - Forced vibrations KW - Cylinders KW - Transverse force KW - SW 6020:Hydraulics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19175678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Fluid+Forces+on+Oscillating+Cylinders&rft.au=Sarpkaya%2C+T&rft.aulast=Sarpkaya&rft.aufirst=T&rft.date=1978-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Drag and Inertia Forces on a Cylinder in Periodic Flow AN - 19122421; 7709017 AB - Experimental results for the drag and added mass coefficients for a smooth circular cylinder in oscillatory flow were presented. The test results were correlated with the Reynolds number with the ratio of the amplitude of the motion to cylinder diameter as a parameter. The low Reynolds number results of Keulegan and Carpenter were replotted in the same format, and together with the present high Reynolds number, results give a fairly complete picture of the variation of the drag and added mass coefficients with Reynolds number for fixed values of the relative amplitude parameter. The results showed that generally both the added mass and drag coefficients are highly dependent on the Reynolds number as well as the relative amplitude parameter. Above as Reynolds number of about 20,000, the two coefficients become essentially independent of the Reynolds number. (Adams-ISWS) JF - Journal of the Waterway, Port, Coastal and Ocean Division, American Society of Civil Engineers Vol. 103, No. WW2, Proceedings Paper No. 12913, p 193-204, May 1977. 6 fig, 6 ref, 2 append. AU - Garrison, C J AU - Field, J B AU - May, MD AD - Naval Postgraduate School Monterey, Calif. Dept. of Mechanical Engineering Y1 - 1977/05// PY - 1977 DA - May 1977 KW - Water Resources Abstracts KW - Drag KW - Hydrodynamics KW - Reynolds number KW - Laboratory tests KW - Hydraulic models KW - Piles(Foundations) KW - Offshore Platforms KW - Analysis KW - Equations KW - Mathematical studies KW - SW 6020:Hydraulics KW - SW 0835:Streamflow and runoff UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19122421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Drag+and+Inertia+Forces+on+a+Cylinder+in+Periodic+Flow&rft.au=Garrison%2C+C+J%3BField%2C+J+B%3BMay%2C+MD&rft.aulast=Garrison&rft.aufirst=C&rft.date=1977-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - The Kinematics of Breaking Waves in the Surf Zone AN - 19188931; 7903379 AB - Simultaneous measurements of sea surface elevation and onshore and alongshore water particle velocities were measured at three locations within the surf zone using two capacitance type penetrating wave staffs and three tow-component electromagnetic flow meters. The probability density functions, pdf, for the sea surface elevation were always highly positively skewed, whereas the pdf 's for the velocities were both negatively and positively skewed. Mean values of the onshore and alongshore components of flow reflected the influence of a rip current frequently observed just south of the instrument location. Strong harmonics in the spectra of sea surface fluctuations and particle velocities infer nonlinear conditions. Coherence values between waves and onshore flow were high, ranging above 0.9. The coherence between waves and onshore flow was used to separate the turbulence and wave-induced velocity components. Over the range of collapsing to spilling breakers a reasonable value for the ratio of turbulent to wave-induced velocity was determined to be approximately 0.75. Saturation regions were found in the wave and velocity energy-density spectra at higher frequencies as evidenced by -5 and -3 slopes, respectively. (Sinha-OEIS) JF - Available from the National Technical Information Service, Springfield VA 22161 as AD-A048 723, Price codes: A05 in paper copy, A01 in microfiche. Naval Postgraduate School Master 's Thesis, September 1977. 68 p, 13 fig, 3 tab, 5 append. AU - Olsen, A J AD - Naval Postgraduate School Monterey, CA Y1 - 1977/04// PY - 1977 DA - Apr 1977 KW - Water Resources Abstracts KW - Rip currents KW - Surf KW - Waves KW - Outer Continental Shelf KW - Nearshore processes KW - Environmental effects KW - Beaches KW - Onshore effects KW - Kinematics KW - SW 0870:Erosion and sedimentation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19188931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=The+Kinematics+of+Breaking+Waves+in+the+Surf+Zone&rft.au=Olsen%2C+A+J&rft.aulast=Olsen&rft.aufirst=A&rft.date=1977-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Kinematics of Breaking Waves in the Surf Zone: Emphasizing Analysis of Identified and Classified Breakers AN - 19145226; 7803279 AB - Measurements were made of the water level fluctuations and horizontal water particle velocities in breaking waves. The breaking waves were identified and classified. The mean value of the height of breaking to depth of breaking was calculated and found to be 0.86 for a composite of the waves measured; the mean ratio values for collapsing, plunging and spilling were 0.84, 0.87 and 0.90, respectively. Probabiltiy distributions were plotted for wave heights and horizontal velocities and qualitatively compared with Rayleigh distributions; the wave distributions fit well but velocity did not. The spectra of wave profile and horizontal velocity were calculated and indicated a narrow banded data set. The coherence values between horizontal water particle velocities and wave profile were generally high, indicating that the horizontal particle velocities measured were highly wave-induced. The phase shift at the peak energy frequency was about 40 degrees which suggested the presence of reflected waves. (Sinha-OEIS) JF - Available from the National Technical Information Service, Springfield VA 22161 as AD-A039 353, Price codes: A04 in paper copy, A01 in microfiche. Thesis for Master of Science in Meteorology and Oceanography, March 1977. 67 p, 22 fig, 2 tab, 20 ref, 3 append. ONR - NR 388-114. AU - Hultstrand, V S AD - Naval Postgraduate School Monterey, CA Y1 - 1977/04// PY - 1977 DA - Apr 1977 KW - Water Resources Abstracts KW - Water level fluctuations KW - Surf KW - Wave profiles KW - Breakers KW - Ocean waves KW - Coasts KW - Reflected waves KW - Breaking waves KW - Kinematics KW - SW 6020:Hydraulics KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19145226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Kinematics+of+Breaking+Waves+in+the+Surf+Zone%3A+Emphasizing+Analysis+of+Identified+and+Classified+Breakers&rft.au=Hultstrand%2C+V+S&rft.aulast=Hultstrand&rft.aufirst=V&rft.date=1977-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - In Situ Acoustic Measurements of Microbubbles at Sea AN - 19160104; 7706916 AB - Excess acoustic attenuations in the frequency range 5-160 kHz were used to deduce densities of bubbles of radius of 15-300 micron at depths of 3-36 m in water up to 1 km deep. The measurements were made over an acoustic path 1-5 m long. Correlations have shown dependence on season, sundown and sunrise, wind, and presence or absence of sea slicks and windrows. These inferred microbubbles are evidently of biological as well as physical origin. (Sims-ISWS) JF - Journal of Geophysical Research Vol. 82, No. 6, p 971-976, February 20, 1977. 7 fig, 11 ref. AU - Medwin, H AD - Naval Postgraduate School Monterey, Calif. Dept. of Physics and Chemistry Y1 - 1977/02// PY - 1977 DA - Feb 1977 KW - Water Resources Abstracts KW - Oceans KW - California KW - Bubbles KW - On-site investigations KW - Measurement KW - Surveys KW - Instrumentation KW - Hydrophones KW - Acoustics KW - Winds KW - Marine biology KW - Oceanography KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19160104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=In+Situ+Acoustic+Measurements+of+Microbubbles+at+Sea&rft.au=Medwin%2C+H&rft.aulast=Medwin&rft.aufirst=H&rft.date=1977-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Old Wine in New Bottles AN - 60846713; 78J0462 AB - This critical note on R. Toronto's general systems model for analyzing organizational change (see SA 24:4/76I0797) draws attention to the article's peculiar data, methodological errors, & questionable generalizations. While the application of general systems theory (GST) holds promise for integrating diverse studies of formal organizations, borrowing the language of GST without its logic compromises the integrity of both GST & organization analysis. AA. JF - Behavioral Science AU - Eoyang, Carson K AU - Haga, William James AD - Naval Postgraduate School, Monterey CA 93940 Y1 - 1977/01// PY - 1977 DA - January 1977 SP - 53 EP - 55 VL - 22 IS - 1 SN - 0005-7940, 0005-7940 KW - organizational change, R. Toronto's general systems model critique KW - data, methodological errors, generalizations KW - Change/Changes KW - General Systems Theory KW - Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing KW - Social research KW - article KW - 0624: complex organizations; bureaucratic structures/organizational sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60846713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Science&rft.atitle=Old+Wine+in+New+Bottles&rft.au=Eoyang%2C+Carson+K%3BHaga%2C+William+James&rft.aulast=Eoyang&rft.aufirst=Carson&rft.date=1977-01-01&rft.volume=22&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Behavioral+Science&rft.issn=00057940&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - BEHSAS N1 - SubjectsTermNotLitGenreText - Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing; Change/Changes; General Systems Theory; Social research ER - TY - JOUR T1 - Rederivation of the Saturation Range in the Frequency Spectrum of Wind-Generated Gravity Waves AN - 19166480; 7705802 AB - The saturation range in the frequency spectrum of wind-generated waves was rederived. Laboratory and theoretical work showed that wave breaking is the result of kinematic instability, suggesting that wave celerity is the governing parameter in the saturation range. Using similarity arguments, a general formulation was rederived, giving the wave profile spectrum S sub eta (omega) is proportional to omega to the (-5) power in deep water as derived by Phillips and S sub eta (omega) is proportional to omega to the (-3) power in shallow water. The velocity spectrum in the saturation range was derived, using linear wave theory as a spectral transfer function. In both deep and shallow water, the horizontal velocity spectrum is S sub u (omega) is proportional to omega to the (-3) power. Wave and velocity measurements made in deep and shallow water are presented, showing agreement with theory. (Sims-ISWS) JF - Journal of Physical Oceanography Vol. 7, No. 1, p 137-140, January 1977. 2 fig, 9 ref. ONR NR-083-275, NR-388-114. AU - Thornton, E B AD - Naval Postgraduate School Monterey, Calif. Dept. of Oceanography Y1 - 1977/01// PY - 1977 DA - Jan 1977 KW - Water Resources Abstracts KW - Waves(Water) KW - Winds KW - Gravity waves KW - Model studies KW - Mathematical models KW - Laboratory tests KW - Frequency analysis KW - Energy KW - Velocity KW - Ocean waves KW - Shallow water KW - Deep water KW - Oceanography KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19166480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Rederivation+of+the+Saturation+Range+in+the+Frequency+Spectrum+of+Wind-Generated+Gravity+Waves&rft.au=Thornton%2C+E+B&rft.aulast=Thornton&rft.aufirst=E&rft.date=1977-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Managerial Professionalism and the Use of Organization Resources AN - 60871291; 77I7716 AB - A popular view among microeconomists regards professionalism among organization managers as contributing to efficiency &, therefore, as being a source of expansion of an organization's size beyond the limits otherwise expected. However, managerial professionalism does not lead to technical efficiency, but to the consumption of organizational resources for competitive performances aimed at impressing outside audiences. The implications of empirical findings from a time series study (see SA1020/H0175) of professionalizing functionaries are discussed, in which professional & nonprofessional orientations in managerial job specialties were studied to analyze "the influence of comparative professionalism upon the shape of similar jobs." Modified HA. JF - The American Journal of Economics and Sociology AU - Haga, William James AD - Naval Postgraduate School, Monterey CA 93940 Y1 - 1976/10// PY - 1976 DA - October 1976 SP - 337 EP - 348 VL - 35 IS - 4 SN - 0002-9246, 0002-9246 KW - managerial professionalism vs organization resources use KW - technical efficiency vs competitive performances promotion, professionalizing functionaries, time series study, discussion KW - Utility/Utilization KW - Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing KW - Resource/Resources KW - Profession/Professions/ Professional/ Professionals/ Professionalism/ Professionalized KW - Managers/Managerial KW - article KW - 0624: complex organizations; bureaucratic structures/organizational sociology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60871291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Economics+and+Sociology&rft.atitle=Managerial+Professionalism+and+the+Use+of+Organization+Resources&rft.au=Haga%2C+William+James&rft.aulast=Haga&rft.aufirst=William&rft.date=1976-10-01&rft.volume=35&rft.issue=4&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Economics+and+Sociology&rft.issn=00029246&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJESA3 N1 - SubjectsTermNotLitGenreText - Organization/Organizations/ Organizational/ Organize/ Organizers/ Organized/ Organizing; Utility/Utilization; Resource/Resources; Profession/Professions/ Professional/ Professionals/ Professionalism/ Professionalized; Managers/Managerial ER - TY - JOUR T1 - The Role of Surface Mixing in the Seasonal Variation of the Ocean Thermal Structure AN - 19159788; 7700362 AB - The role of surface-generated mixing in determining the seasonal variation of the ocean thermal structure was investigated using a one-dimensional numerical model. The model contained vertical eddy diffusion with a constant coefficient K sub H = 0.5 sq cm/s , an instantaneous convective adjustment mechanism as commonly used in oceanic general circulation models, and a simple parameterization of surface-generated wind and convective mixing based on recent mixed-layer theories. Forcing on the seasonal time scale was accomplished by prescribing the atmospheric solar radiation, long-wave radiation, wind speed, temperature, and dew point to vary sinusoidally with the annual period. Results of model integrations showed that surface-generated wind and convective mixing were responsible for producing many features which were observed in the real ocean, including the occurrence of two sea surface temperature maxima--one in summer and another in early fall. (Sims-ISWS) JF - Journal of Physical Oceanography Vol. 6, No. 4, p 504-510, July 1976. 7 fig, 1 tab, 16 ref. ONR N00014-76-WR-60020. AU - Haney, R L AU - Davies, R W AD - Naval Postgraduate School Monterey, Calif. Dept. of Meteorology Y1 - 1976/07// PY - 1976 DA - Jul 1976 KW - Water Resources Abstracts KW - Model studies KW - Oceans KW - Water temperature KW - Pacific Ocean KW - Mixing KW - Mathematical models KW - Temperature KW - Seasonal KW - Equations KW - Heat transfer KW - Climatology KW - Oceanography KW - Meteorology KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19159788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=The+Role+of+Surface+Mixing+in+the+Seasonal+Variation+of+the+Ocean+Thermal+Structure&rft.au=Haney%2C+R+L%3BDavies%2C+R+W&rft.aulast=Haney&rft.aufirst=R&rft.date=1976-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Social Cost of Oil Pollution AN - 19180421; 7711892 AB - A method of improving decision making relative to the problems created by oil spillage is investigated. This thesis uses a simulation to consider the spread and damage caused by oil spills using data from San Francisco Bay. A projection of social costs from these spills has been made. Formulation of a methodology for deriving the social cost of oil spills is a prerequisite in reaching optimal, rational decisions in managing oil pollution. Such decisions may include the establishment of a fine structure, determination of the required level of clean-up and identification of socially significant spills. (Sinha - OEIS) JF - Available from the National Technical Information Service, Springfield VA 22161 as AD/A-027 257, Price codes: A04 in paper copy, A01 in microfiche. Master 's Thesis, March 1976. 67 p, 10 fig, 17 reg, 2 append. AU - Mudjiardjo, H S AD - Naval Postgraduate School Monterey, Calif Y1 - 1976/04// PY - 1976 DA - Apr 1976 KW - Water Resources Abstracts KW - Oil pollution KW - Oil spills KW - Economics KW - Water pollution effects KW - Baseline studies KW - Resources development KW - Environmental effects KW - Damages KW - California KW - SW 3070:Water quality control KW - SW 3030:Effects of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19180421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Social+Cost+of+Oil+Pollution&rft.au=Mudjiardjo%2C+H+S&rft.aulast=Mudjiardjo&rft.aufirst=H&rft.date=1976-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A Program for the Stability Analysis of Pipe Poiseuille Flow AN - 19172441; 7710984 AB - Solutions obtained using the theory and computer program developed by a previous investigator indicated decreasing flow stability with decreasing Reynolds number, a result which is clearly inconsistent with theory and experimental data. This study reported the attempt to isolate sources of error causing incorrect computer solutions for the three-dimensional linearized vorticity transport equation for pipe Poiseuille flow. The problem was analyzed in three phases. The first phase consisted of ensuring accurate expression of the vorticity transport equation in terms of complex velocity vector potential. In the second phase, an extensive examination of the conditions required to satisfy the vorticity transport equation at the singular point on the axis of symmetry of the pipe was made. The third phase entailed establishing a finite difference approximation of the equation and its boundary conditions for adaptation of the problem to a standard form for computer solution. (Singh-ISWS) JF - Available from the National Technical Information Service, Springfield VA 22161 as AD-A024 927, Price codes: A04 in paper copy, A01 in microfiche. Masters thesis, March 1976. 75 p, 3 fig, 5 tab, 1 ref. AU - Johnston, RHIII AD - Naval Postgraduate School Monterey, Calif Y1 - 1976/04// PY - 1976 DA - Apr 1976 KW - Water Resources Abstracts KW - Pipe flow KW - Vortices KW - Analytical techniques KW - Fluid mechanics KW - Boundary processes KW - Reynolds number KW - Computer programs KW - Laminar flow KW - Mathematics KW - Numerical analysis KW - SW 6020:Hydraulics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19172441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+Program+for+the+Stability+Analysis+of+Pipe+Poiseuille+Flow&rft.au=Johnston%2C+RHIII&rft.aulast=Johnston&rft.aufirst=RHIII&rft.date=1976-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Breaking Wave Criterion On a Sloping Beach AN - 19168500; 7711585 AB - The various wave theories, theoretical breaking criteria, and derived breaking criteria were reviewed for shallow water waves. To account for the nonlinear hydrodynamics present in a shallow water wave breaking on a beach with a sloping bottom, the perturbation technique of Iwagaki and Sakai was used to derive a second order expression for the horizontal water particle velocity for long waves. The kinematic breaking criterion was applied to the derived wave phase speed and horizontal water particle velocity values to establish breaking. The results indicated that the ratios of elevation of free surface referenced to still water level at breaking point to deep water wave length (N sub b/L sub o) and the depth of water referenced to still water level at breaking point to deep water wave height (h sub b/H sub o) provide reliable breaking criteria. Each of the parameters was dependent only upon beach slope and H sub o/L sub o. Theoretically derived values for h sub b/H sub o compared favorably with field measurements and offered improvement over previous theory. Predicted breaking depths were less than those present in experimental data, susggesting extension to higher orders may be warranted. (Bhowmik-ISWS) JF - Available from the National Technical Information Service, Springfield VA 22161 as AD-A032 323, Price codes: A05 in paper copy, A01 in microfiche. Master 's Thesis, Sept. 1976. 97 p, 14 fig, 1 tab, 42 ref, 2 append. AU - Smith, R M AD - Naval Postgraduate School Monterey, Calif Y1 - 1976/04// PY - 1976 DA - Apr 1976 KW - Water Resources Abstracts KW - Waves(Water) KW - Shallow water KW - Hydrodynamics KW - Beaches KW - Velocity KW - Slopes KW - Laboratory tests KW - Equations KW - Mathematical studies KW - SW 0850:Lakes KW - SW 6020:Hydraulics KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19168500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Breaking+Wave+Criterion+On+a+Sloping+Beach&rft.au=Smith%2C+R+M&rft.aulast=Smith&rft.aufirst=R&rft.date=1976-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - An Evaluation of a Computer Simulation Model of Plankton Dynamics in Monterey Bay AN - 19162691; 7804480 AB - A computer simulation model of the phosphate, phytoplankton and zooplankton dynamics in Monterey Bay has been examined and modified. The model is driven by four forcing functions expressed as annual cycles of upwelling velocity, incident solar radiation, mixed layer depth, and mixed layer temperature. An alternate upwelling index has been developed based on the local wind field. A revised radiation index is employed based on the generation of both advective fog and low stratus cloud cover common during upwelling on the California coast. Analysis of the model 's response to sinking and advection of phytoplankton has been examined. The importance of seasonal increases in predators has been introduced as a controlling factor in the seasonal growth of zooplankton. The model is able to predict the seasonal trends of phosphate, phytoplankton, and zooplankton throughout the year. (Bell-Cornell) JF - Available from the National Technical Information Service, Springfield VA 22161 as ADA-032 294, Price codes: A05 in paper copy, A01 in microfiche. Masters Thesis, September 1976. 93 p, 28 fig, 23 ref , 3 append. AU - Henrickson, DE AD - Naval Postgraduate School Monterey, CA Y1 - 1976/04// PY - 1976 DA - Apr 1976 KW - Water Resources Abstracts KW - Evaluation KW - Computer models KW - Simulation analysis KW - Plankton dynamics KW - Monterey Bay(Cal) KW - Phosphates KW - Zooplankton KW - Phytoplankton KW - Forcing functions KW - Upwelling KW - Advection KW - Predation pressure KW - Radiation index KW - Algal sinking KW - Systems analysis KW - Equations KW - California KW - SW 5080:Evaluation, processing and publication KW - SW 3030:Effects of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19162691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=An+Evaluation+of+a+Computer+Simulation+Model+of+Plankton+Dynamics+in+Monterey+Bay&rft.au=Henrickson%2C+DE&rft.aulast=Henrickson&rft.aufirst=DE&rft.date=1976-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - WAVE FORCES ON BOTTOM-MOUNTED LARGE-DIAMETER CYLINDER AN - 19151674; 7606395 AB - A SYSTEMATIC SERIES OF TESTS WERE CONDUCTED TO DETERMINE THE HORIZONTAL AND UPLIFT FORCES ACTING ON A BOTTOM-MOUNTED HORIZONTAL CIRCULAR CYLINDER. THE MAXIMUM VALUE OF HORIZONTAL FORCE TENDED TO VARY LINEARLY WITH WAVE HEIGHT FOR THE TEST RANGE OF 15 TO 120 FOR THE RATIO OF THE SQUARE OF WAVE PERIOD TO WATER DEPTH. THE UPLIFT FORCES COMPRISE TWO COMPONENTS, DYNAMIC LIFT AND AN INERTIA PART. THE LATTER CAN BE REPRESENTED BY FROUDE-KRILOV FORCE. THE MAXIMUM UPLIFT FORCE GENERALLY OCCURRED AT THE WAVE TROUGH WHERE THE INERTIAL AND DYNAMIC COMPONENTS ARE ADDITIVE. THE UPLIFT FORCE IS PRIMARILY ATTRIBUTABLE TO THE DYNAMIC LIFT AND IS DEPENDENT ON THE LIFT COEFFICIENT WHICH IS IN TURN DEPENDENT ON THE RELATIVE MAGNITUDE OF THE PARTICLE DISPLACEMENT. AS THE WAVE HEIGHT INCREASES, A POINT IS REACHED WHERE GROSS FLOW SEPARATION AND CORRESPONDING REDUCTION IN LIFT COEFFICIENT OCCURS. (SINGH-ISWS) JF - JOURNAL OF THE WATERWAYS, HARBORS AND COASTAL ENGINEERING DIVISION, AMERICAN SOCIETY OF CIVIL ENGINEERS, VOL. 101, NO. WW4, PROCEEDINGS PAPER 11699, P 343-356, NOVEMBER 1975. 4 FIG, 10 REF, 2 APPEND. AU - Garrison, C J AU - Gehrman, F H AU - Perkinson, B T AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF. DEPT. OF MECHANICAL ENGINEERING Y1 - 1975/11// PY - 1975 DA - Nov 1975 KW - Water Resources Abstracts KW - *HARBORS KW - *HYDRODYNAMICS KW - *PIPELINES KW - *WAVES(WATER) KW - *DYNAMICS KW - TESTING KW - DIMENSIONAL ANALYSIS KW - PRESSURE KW - REGRESSION ANALYSIS KW - STRAIN GAGES KW - UPLIFT PRESSURE KW - *UNDERWATER PIPELINE KW - INERTIA FORCE KW - WAVE HEIGHT KW - SW 0850:Lakes KW - SW 6020:Hydraulics KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19151674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=WAVE+FORCES+ON+BOTTOM-MOUNTED+LARGE-DIAMETER+CYLINDER&rft.au=Garrison%2C+C+J%3BGehrman%2C+F+H%3BPerkinson%2C+B+T&rft.aulast=Garrison&rft.aufirst=C&rft.date=1975-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - COMPARISON OF HYDRAULIC AND NUMERICAL TIDAL MODELS AN - 19174382; 7610446 AB - A COMPARISON WAS MADE OF THE MERITS AND LIMITATIONS OF HYDRAULIC AND NUMERICAL MODELS. THE DISCUSSION WAS LIMITED TO MODELS HAVING UNIFORM DENSITY OVER DEPTH AND THE DRIVING FORCE IS THE TIDE ONLY. THE MODEL COMPARISON WAS FOR SAN DIEGO BAY. PROTOTYPE MEASUREMENTS WERE USED TO CALIBRATE BOTH MODELS. COMPARABLE RESULTS WERE OBTAINED FROM THE HYDRAULIC AND NUMERICAL MODELS DEPENDENT ON HOW WELL THEY WERE CALIBRATED. TECHNIQUES WERE DESCRIBED TO DIVIDE LARGE ARRAYS REPRESENTING EMBAYMENTS IN THE NUMERICAL MODEL INTO SMALLER SEGMENTS THAT ARE HANDLED MORE EASILY AND FASTER IN THE COMPUTER. THIS TECHNIQUE CAN ALLOW USING FINER MESH LENGTHS TO OBTAIN BETTER SPATIAL RESOLUTION. (SEE ALSO W76-10415) (SIMS-ISWS) JF - IN: SYMPOSIUM ON MODELING TECHNIQUES, VOLUME II; 2ND ANNUAL SYMPOSIUM OF THE WATERWAYS, HARBORS AND COASTAL ENGINEERING DIVISION OF ASCE (2 VOL.), SAN FRANCISCO, CALIFORNIA, SEPTEMBER 3-5, 1975. AMERICAN SOCIETY OF CIVIL ENGINEERS, NEW YORK, P 1311-1328, 1975. 5 FIG, 10 REF. AU - Thornton, E B AU - Romer, L S AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF. DEPT. OF OCEANOGRAPHY Y1 - 1975/09// PY - 1975 DA - Sep 1975 KW - Water Resources Abstracts KW - *MODEL STUDIES KW - *BAYS KW - *TIDAL WATERS KW - MATHEMATICAL MODELS KW - HYDRAULIC MODELS KW - TIDES KW - TIDAL EFFECTS KW - CURRENTS(WATER) KW - CIRCULATION KW - WATER CIRCULATION KW - ESTUARIES KW - INLETS(WATERWAYS) KW - HYDRAULICS KW - HYDRODYNAMICS KW - *SAN DIEGO BAY(CALIF) KW - SW 6020:Hydraulics KW - SW 0810:General KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19174382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=COMPARISON+OF+HYDRAULIC+AND+NUMERICAL+TIDAL+MODELS&rft.au=Thornton%2C+E+B%3BRomer%2C+L+S&rft.aulast=Thornton&rft.aufirst=E&rft.date=1975-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Development of an Oil-Water Pollution Monitoring System AN - 19174021; 7703908 AB - The progress made during FY75 in the fabrication and the testing of an automatic oil pollution monitoring system is documented. In the system developed, a Direct Difference method of Total Organic Carbon determination was utilized to ascertain oil concentrations. Using this monitor, it was possible to specify the concentration of any oil, independent of type, in an oil separator effluent sample. In the final phases of the study, preliminary investigations on prototype improvements were initiated and oil concentrations of bilge water samples were determined. (Sinha-OEIS) JF - Available from the National Technical Information Service, Springfield VA 22161 as AD-A014 552, Price codes: A05 in paper copy, A01 in microfiche. Report No. NPS-59Hm75071A, July 1975. 89 p, 29 fig, 8 tab, 8 ref, 4 append. AU - Houlihan, T M AU - Tyler, B D AD - Naval Postgraduate School Monterey, Calif Y1 - 1975/04// PY - 1975 DA - Apr 1975 KW - Water Resources Abstracts KW - Pollutant identification KW - Oil pollution KW - Monitoring KW - Sampling KW - Water pollution KW - Water resources KW - Analytical techniques KW - Oil KW - Baseline studies KW - Environmental effects KW - Fuel oil KW - SW 4070:Ecological impact of water development KW - SW 3010:Identification of pollutants KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19174021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Development+of+an+Oil-Water+Pollution+Monitoring+System&rft.au=Houlihan%2C+T+M%3BTyler%2C+B+D&rft.aulast=Houlihan&rft.aufirst=T&rft.date=1975-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - An Analysis of the Management Information System for U.S. Coast Guard Aircraft Pollution Patrols AN - 19173352; 7712562 AB - The purpose of this thesis is to examine the present data collected and to evaluate its usage in respect to pollution detection by Coast Guard aircraft patrols. It was found that, in general, more detailed and specific information is needed about the patrols. A system for collecting this new data and linking it to the present Pollution Incident Reporting System data base is proposed. The proposed system would allow evaluation of patrols at more specific areas and levels instead of the present district, coast and nationwide levels. Policy decisions could then be more specifically oriented to an area and/or the individual air station. (Sims-ISWS) JF - Available from the National Technical Information Service, Springfield VA 22161 as AD-A021 785, Price codes: A07 in paper copy, A01 in microfiche. Master 's Thesis, December 1975. 144 p, 39 fig, 20 tab, 17 ref, 8 append. AU - Heinz, J H AD - Naval Postgraduate School Monterey, Calif Y1 - 1975/04// PY - 1975 DA - Apr 1975 KW - Water Resources Abstracts KW - Pollutant identification KW - Water pollution KW - Monitoring KW - Oil spills KW - Aircraft KW - Water pollution sources KW - Data processing KW - Management KW - Pollutants KW - Oil KW - Coasts KW - Oceans KW - Harbors KW - Estuaries KW - Oil pollution KW - Remote sensing KW - SW 5080:Evaluation, processing and publication KW - SW 5040:Data acquisition KW - SW 3010:Identification of pollutants KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19173352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=An+Analysis+of+the+Management+Information+System+for+U.S.+Coast+Guard+Aircraft+Pollution+Patrols&rft.au=Heinz%2C+J+H&rft.aulast=Heinz&rft.aufirst=J&rft.date=1975-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - MESOSCALE COMPONENT OF THE GEOSTROPHIC FLOW AND ITS TEMPORAL AND SPATIAL VARIABILITY IN THE CALIFORNIA CURRENT OFF MONTEREY BAY IN 1973-74 AN - 19170927; 7612387 AB - THE MESOSCALE COMPONENTS OF THE GEOSTROPHIC FLOW AND ITS TEMPORAL AND SPATIAL VARIABILITY ARE DISCUSSED FOR THE OCEANIC REGION WEST OF THE CONTINENTAL SHELF OFF MONTEREY BAY. THE RESULTS WERE OBTAINED FROM SPATIALLY DENSE OBSERVATIONS ON THIRTEEN CRUISES BETWEEN AUGUST 1973 AND AUGUST 1974. PATTERNS OF CURRENT FLOW INDICATED BY DROGUES AND GEOSTROPHY TEND TO CONFIRM AN ANALYSIS OF THE STRUCTURE WHICH HAS ALTERNATING ELEMENT OF POLEWARD AND EQUATORWARD FLOW. SURFACE CURRENT FLOW PATTERNS ARE SIMILAR TO THOSE FOUND AT DEPTHS TO 375 M. THE BOTTOM TOPOGRAPHY INFLUENCES THE DIRECTION OF FLOW INSIDE THE 1,000 FATHOM CURVE. SEASONAL VARIATIONS OF THE GEOSTROPHIC FLOW AND SALT TRANSPORT WERE CONGRUENT WITH SKOGSBERG'S (1936) ANNUAL CYCLE COMPOSED OF THREE DISTINCT OCEANOGRAPHIC SEASONS. THE FLOW AND STRUCTURE IN THE AREA ARE COMPLEX WITH FLOW ELEMENTS LESS THAN 10 KM IN WIDTH. THE DATA SUGGEST THAT OBSERVATIONS ON A SAMPLING GRID LENGTH LESS THAN 10 KM TRANSVERSE TO THE CURRENT FLOW, AND EXTENSIVE INDEPENDENT CURRENT MEASUREMENTS ARE REQUIRED TO DESCRIBE ADEQUATELY THE SMALL-SCALE FEATURES OF THE FLOW, STRUCTURE AND ITS TIME VARIATIONS. (SINHA-OEIS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, SPRINGFIELD, VA 22161 AS AD-A019 284, $7.50 IN PAPER COPY, $3.00 IN MICROFICHE. MASTER'S THESIS, SEPTEMBER 1975. 179 P, 13 REF. AU - Greer, R E AD - NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIF Y1 - 1975/04// PY - 1975 DA - Apr 1975 KW - Water Resources Abstracts KW - *CONTINENTAL SHELF KW - *FLOW CHARACTERISTICS KW - *CURRENTS(WATER) KW - *CALIFORNIA KW - *PACIFIC OCEAN KW - WATER PROPERTY KW - WATER RESOURCES KW - SALINITY KW - WATER CIRCULATION KW - VARIABILITY KW - SPATIAL DISTRIBUTION KW - TEMPORAL DISTRIBUTION KW - *OUTER CONTINENTAL SHELF KW - *GEOSTROPHIC FLOW KW - *BOTTOM TOPOGRAPHY KW - SEASONAL VARIATIONS KW - MESOSCALE COMPONENT KW - SURFACE CURRENTS KW - SALT TRANSPORT KW - *MONTEREY BAY(CA) KW - SW 5080:Evaluation, processing and publication KW - SW 3020:Sources and fate of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19170927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=MESOSCALE+COMPONENT+OF+THE+GEOSTROPHIC+FLOW+AND+ITS+TEMPORAL+AND+SPATIAL+VARIABILITY+IN+THE+CALIFORNIA+CURRENT+OFF+MONTEREY+BAY+IN+1973-74&rft.au=Greer%2C+R+E&rft.aulast=Greer&rft.aufirst=R&rft.date=1975-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Economic Effects of Enforcement Variables on Commercial Oil Pollution Control Strategy AN - 19168824; 7702418 AB - The decision making process of firms engaged in potentially oil polluting activities is analyzed in an effort to isolate the effects of penalties and other pollution costs which may motivate pollution control. An economic decision model for oil pollution control strategy is developed on the basis of 1973 and 1974 data taken from the Coast Guard 's Pollution Incident Reporting System. The model and analysis breakdown the major internal and external decision parameters and show the impact of civil penalties, cleanup costs, and internal costs on a firm 's pollution control strategy. Civil penalties appear to be most effective in controlling minor spills, since the costs of product lost and expected cleanup are small relative to the penalties. As the spills increase in size, costs of cleanup and loss of product become much more important while the civil penalty becomes negligible. Cleanup costs have a significant impact on the decision in that they account for the largest portion of the external costs that the firm must internalize. However, application of the model to large scale spills reveals that the firm 's internal costs have the largest influence on its pollution control strategy. This model may be extended into other areas such as fisheries enforcement, other forms of pollution control, and government intervention and regulation. (Luedtke-Wisconsin) JF - Available from the National Technical Information Service, Springfield VA 22161 as ADA-016 442, Price codes: A05 in paper copy, A01 in microfiche. MS thesis, September 1975. 91 p. 8 fig., 10 tab., 24 ref., 3 append. AU - Cook, R C AD - Naval Postgraduate School Monterey, Calif Y1 - 1975/04// PY - 1975 DA - Apr 1975 KW - Water Resources Abstracts KW - Oil spills KW - Decision making KW - Economic justification KW - Industries KW - Oil pollution KW - Pollution abatement KW - Model studies KW - Evaluation KW - Water pollution control KW - Law enforcement KW - Costs KW - Penalties(Legal) KW - Management KW - Attitudes KW - SW 3070:Water quality control KW - SW 4020:Evaluation process KW - SW 1050:Conservation in industrial use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19168824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Economic+Effects+of+Enforcement+Variables+on+Commercial+Oil+Pollution+Control+Strategy&rft.au=Cook%2C+R+C&rft.aulast=Cook&rft.aufirst=R&rft.date=1975-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Subtidal Concrete Piling Fauna in Monterey Harbor, California AN - 19164241; 7701783 AB - Fouling organisms were collected and identified from a wharf concrete piling in Monterey Harbor, California. Collections were made over the piling 's length from the lowest part of the intertidal zone to the bottom 7.1 m below zero tide level. The piling was dominated by Metridium senile and dense colonies of Phoronis vancouverensis at intermediate depths, with Phyllochaetopterus prolifica occupying the shallow depths. Species of Protozoa, Porifera, Coelenterata, Platyhelminthes, Nemertea, Sipuncula, Annelida, Arthropoda, Mollusca, Bryozoa, Phoronida, Echinodermata, and Cherdata as well as the algae Phaeophyta and Rhodophyta are tabulated as to size, depth distribution and abundance. Species are identified to phyla and drawings illustrate the more prominent animals. (Auen-Wisconsin) JF - Available from the National Technical Information Service, Springfield VA 22161 as ADA-016 573, Price codes: A05 in paper copy, A01 in microfiche. Master 's thesis, September 1975. 83 p. 18 fig., 4 tab., 19 ref. AU - Donat, W AD - Naval Postgraduate School Monterey, Calif Y1 - 1975/04// PY - 1975 DA - Apr 1975 KW - Water Resources Abstracts KW - Marine animals KW - Marine algae KW - Fouling KW - Concrete piles KW - California KW - Pollutant identification KW - Varieties KW - Biomass KW - Water pollution KW - SW 3010:Identification of pollutants KW - SW 3030:Effects of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19164241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Subtidal+Concrete+Piling+Fauna+in+Monterey+Harbor%2C+California&rft.au=Donat%2C+W&rft.aulast=Donat&rft.aufirst=W&rft.date=1975-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - DEVELOPMENT OF AN OIL-WATER POLLUTION MONITORING SYSTEM AN - 19163574; 7607092 AB - THE PROTOTYPE OF AN AUTOMATIC OIL POLLUTION MONITOR WAS BUILT AND TESTED. IN THE SYSTEM DEVELOPED, A DIRECT DIFFERENCE METHOD OF TOTAL ORGANIC CARBON DETERMINATION WAS UTILIZED TO ASCERTAIN OIL CONCENTRATIONS. USING THIS MONITOR, IT WAS POSSIBLE TO SPECIFY THE CONCENTRATION OF ANY OIL, INDEPENDENT OF TYPE, IN A KNOWN WATER SAMPLE. IN THE FINAL PHASES OF THE STUDY, PRELIMINARY INVESTIGATIONS ON PROTOTYPE IMPROVEMENTS AND OIL CONCENTRATION DETERMINATIONS IN BILGE WATER WERE INITIATED. (HENLEY - ISWS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, SPRINGFIELD, VA. 22161, AS AD/A-012 460 $5.00 IN PAPER COPY, $2.25 IN MICROFICHE. MASTER'S THESIS, JUNE 1975. 89 P, 29 FIG, 8 TAB, 8 REF, 4 APPEND. AU - Tyler, B D AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1975/04// PY - 1975 DA - Apr 1975 KW - Water Resources Abstracts KW - *OIL POLLUTION KW - *OIL WASTES KW - *MONITORING KW - *POLLUTANT IDENTIFICATION KW - *OIL KW - ANALYTICAL TECHNIQUES KW - WATER POLLUTION SOURCES KW - WATER POLLUTION CONTROL KW - WATER QUALITY KW - FUELS KW - OILY WATER KW - WASTE WATER DISPOSAL KW - OIL SPILLS KW - CARBON KW - MEASUREMENT KW - INSTRUMENTATION KW - OCEANS KW - CHEMICAL ANALYSIS KW - *BILGE WASTES KW - BALLAST WATER KW - TOTAL ORGANIC CARBON KW - BECKMAN MODEL 915 KW - MINERAL ANALYSIS KW - INORGANIC CARBON KW - SW 5040:Data acquisition KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19163574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=DEVELOPMENT+OF+AN+OIL-WATER+POLLUTION+MONITORING+SYSTEM&rft.au=Tyler%2C+B+D&rft.aulast=Tyler&rft.aufirst=B&rft.date=1975-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - UPDATING THE NAVY ENVIRONMENTAL PROTECTION DATA BASE TO INCORPORATE OIL SPILL CLEAN-UP PERFORMANCE AN - 19161546; 7608320 AB - IN THIS THESIS, PROPOSALS WERE FORMULATED ON METHODS OF REPORTING, COLLECTING, AND DISSEMINATING INFORMATION ON THE SURROUNDING CONDITIONS OF AN OIL SPILL TO AND FROM THE NAVY ENVIRONMENTAL PROTECTION DATA BASE. THE REPORTING ASPECT CONSISTS OF A CONTINGENCY PLAN AND TWO REPORTS, AN INITIAL REPORT AND AN AFTER ACTION REPORT. SUCH A REPORTING METHOD IS POSSIBLE BECAUSE OF A PROPOSED RETRIEVAL SYSTEM. THE DATA COLLECTION METHOD EMPHASIZES INFORMATION THAT WILL PRODUCE AN ACCURATE COST FIGURE. THE DISSEMINATION PROCESS CONSISTS OF NEW REPORT FORMATS TO BE INCLUDED IN THE QUARTERLY SUMMARY REPORTS. (SIMS-ISWS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, SPRINGFIELD, VA 22161 AS AD-A012 663, $4.25 IN PAPER COPY, $2.25 IN MICROFICHE. MASTER'S THESIS, JUNE 1975. 70 P, 11 FIG, 9 REF, 5 APPEND. AU - Antonelli, J AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1975/04// PY - 1975 DA - Apr 1975 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *OIL POLLUTION KW - *WATER POLLUTION KW - *INFORMATION RETRIEVAL KW - COMPUTERS KW - DATA TRANSMISSION KW - SHIPS KW - WATER POLLUTION SOURCES KW - WATER POLLUTION CONTROL KW - MILITARY ASPECTS KW - HARBORS KW - ESTUARIES KW - *REPORTING SYSTEMS KW - *DATA BASES KW - COMPUTER DATA BASES KW - OIL-SPILL CLEAN-UP KW - SW 5040:Data acquisition KW - SW 3070:Water quality control KW - SW 3020:Sources and fate of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19161546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=UPDATING+THE+NAVY+ENVIRONMENTAL+PROTECTION+DATA+BASE+TO+INCORPORATE+OIL+SPILL+CLEAN-UP+PERFORMANCE&rft.au=Antonelli%2C+J&rft.aulast=Antonelli&rft.aufirst=J&rft.date=1975-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Tidal and Current Prediction for the Amazon 's North Channel Using a Hydrodynamical-Numerical Model AN - 19155853; 7707743 AB - The hydrodynamical-numerical prediction model developed by W. Hansen is applied to the North Channel of the Amazon River for computation of tides and currents; the results are compared with tidal prediction obtained by the harmonic method and to actual current measurements. A medium size grid of square mesh cells, 1800 m in length, represents the North Channel. The driving forces are the tides at the northern opening of the channel near the river 's mouth and the river discharge into the channel at the southern end. The numerical results for tides were verified at three tidal stations, and it was observed that the tides predicted at the northern part of the channel agreed, in the worse case, within 12% of the tidal range, but those predicted at the southern end were unsatisfactorily reproduced. This fact is attributed to the size of the grid which is too coarse to describe adequately the variable and irregular cross-sections and bottom topography at the southern part the channel. The predicted currents were in acceptable agreement with a few available measurements. (Sinh-OEIS) JF - Available from the National Technical Information Service Springfield VA 22161 as AD-A017 572. Master 's Thesis, September 1975. 82 p, 22 fig, 3 tab, 21 ref, append. AU - Ferraz, LA AD - Naval Postgraduate School Monterey, Calif Y1 - 1975/04// PY - 1975 DA - Apr 1975 KW - Water Resources Abstracts KW - Tides KW - Currents(Water) KW - Estuaries KW - Water resources development KW - Model studies KW - Hydrodynamics KW - Mathematical models KW - SW 0810:General KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19155853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Tidal+and+Current+Prediction+for+the+Amazon+%27s+North+Channel+Using+a+Hydrodynamical-Numerical+Model&rft.au=Ferraz%2C+LA&rft.aulast=Ferraz&rft.aufirst=LA&rft.date=1975-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - MESOSCALE SPATIAL AND TEMPORAL VARIATIONS OF WATER MASS CHARACTERISTICS IN THE CALIFORNIA CURRENT REGION OFF MONTEREY BAY IN 1973-1974 AN - 19155576; 7612386 AB - CONTINUOUS SALINITY AND/OR TEMPERATURE PROFILES WERE MADE OFF THE COAST OF MONTEREY BAY MONTHLY BETWEEN AUGUST 1973 AND AUGUST 1974 AND ON A SPATIAL GRID FINER THAN IS CONVENTIONALLY USED. A PROCEDURE IS DESCRIBED TO CONVERT THE DATA FROM ANALOG TO DIGITAL FORM, PROCESS THESE DATA ON AN IBM 360 COMPUTER, AND PRINT OUT THE RESULTS BY STATION FOR EACH MONTH. THE RESULTS SHOW WATER MASS FEATURES OF SMALL SPATIAL SCALE DETECTABLE ONLY BECAUSE OF THE SMALL GRID SPACING. A GYRE OR FILAMENT STRUCTURE IS SUGGESTED BY THE NORTH TO SOUTH VARIATION BETWEEN LINES OF STATIONS. THE EXTENT OF THE AREA OF SURVEY IS INSUFFICIENT TO DESCRIBE COMPLETELY THE WATER MASS STRUCTURE ON BOTH THE EASTERN AND WESTERN BOUNDARIES; HOWEVER, THE TEMPORAL VARIATION IN THE OBSERVED WATER MASS STRUCTURE IS CONSISTENT WITH THE THREE OCEANOGRAPHIC SEASONS DESCRIBED FOR THE CALIFORNIA CURRENT SYSTEM. ELEMENTS OF RELATIVELY COLD WATER AND RELATIVELY WARM WATER MASSES ARE IDENTIFIED IN THE AREA OF SURVEY. (SINHA-OEIS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, SPRINGFIELD, VA 22161 AS ADA-019 283, $6.00 IN PAPER COPY, $3.00 IN MICROFICHE. MASTER'S THESIS, SEPTEMBER 1975. 142 P, 19 FIG, 2 TAB, 10 REF, 8 APPEND. AU - Blumberg, R E AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1975/04// PY - 1975 DA - Apr 1975 KW - Water Resources Abstracts KW - *CURRENTS(WATER) KW - *CALIFORNIA KW - *PROFILES KW - *PACIFIC OCEAN KW - *SALINITY KW - *VARIABILITY KW - WATER PROPERTIES KW - DATA PROCESSING KW - COASTS KW - BAYS KW - WATER TEMPERATURE KW - SPATIAL DISTRIBUTION KW - TEMPORAL DISTRIBUTION KW - *CALIFORNIA CURRENT SYSTEM KW - MESOSCALE VARIATIONS KW - WATER MASSES KW - *MONTEREY BAY(CA) KW - SALINITY PROFILES KW - SW 5080:Evaluation, processing and publication KW - SW 3020:Sources and fate of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19155576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=MESOSCALE+SPATIAL+AND+TEMPORAL+VARIATIONS+OF+WATER+MASS+CHARACTERISTICS+IN+THE+CALIFORNIA+CURRENT+REGION+OFF+MONTEREY+BAY+IN+1973-1974&rft.au=Blumberg%2C+R+E&rft.aulast=Blumberg&rft.aufirst=R&rft.date=1975-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - ACOUSTIC MINIPROBING FOR OCEAN MICROSTRUCTURE AND BUBBLES AN - 19123530; 7508425 AB - ANALYSIS OF SOUND PHASE AND AMPLITUDE FLUCTUATIONS OVER A 1-M RANGE HAS PROVIDED IN SITU STATISTICS THAT CAN BE USED TO INFER THE STATISTICS OF THE OCEAN MICROSTRUCTURE. A PARTICULARLY FRUITFUL USE OF SUCH A SIMPLE ACOUSTIC MINIPROBE IS THE STUDY OF THE SOUND PHASE FLUCTUATIONS NEAR THE SEA SURFACE. WITH THE AID OF SIMULTANEOUS STATISTICS OF TEMPERATURE AND WAVE HEIGHT THE OBSERVED SOUND PHASE FLUCTUATIONS WERE USED TO CALCULATE BUBBLE STATISTICS AT SEA. AT SOUND FREQUENCIES LESS THAN ABOUT 25 KHZ THE SOUND SPEED DISPERSION AND ITS FLUCTUATIONS REVEAL THE BUBBLE VOLUME FRACTION AND ITS STANDARD DEVIATION, RESPECTIVELY. AT HIGHER SOUND FREQUENCIES A LARGE RESONANT BUBBLE POPULATION CAN BE IDENTIFIED BY A CROSS CORRELATION OF SOUND PHASE AND OCEAN WAVE HEIGHT. IN THIS CASE THE PREDOMINANT PART OF THE SOUND PHASE MODULATION IS CAUSED BY THE CHANGING BUBBLE RADIUS DUE TO THE FLUCTUATING WAVE HEIGHT. THE SPECTRUM OF THE SOUND PHASE MODULATION THEN MIMICS THE OCEAN WIND WAVE SPECTRUM, AND ITS CHANGE WITH DEPTH CAN BE USED TO INFER THE CHANGE OF NUMBER OF RESONANT BUBBLES WITH DEPTH. (SIMS-ISWS) JF - JOURNAL OF GEOPHYSICAL RESEARCH, VOL 80, NO 3, P 405-413, JANUARY 20, 1975. 11 FIG, 2 TAB, 15 REF. AU - MEDWIN, H AU - Fitzgerald, J AU - RAUTMANN, G AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF. DEPT. OF PHYSICS AND CHEMISTRY Y1 - 1975/01// PY - 1975 DA - Jan 1975 KW - Water Resources Abstracts KW - *OCEANS KW - *BUBBLES KW - *ACOUSTICS KW - ON-SITE DATA COLLECTIONS KW - INSTRUMENTATION KW - MEASUREMENT KW - SOUND WAVES KW - HYDROPHONES KW - OCEANOGRAPHY KW - STATISTICS KW - *OCEAN MICROSTRUCTURE KW - SOUND SPEED KW - SW 0835:Streamflow and runoff KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19123530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=ACOUSTIC+MINIPROBING+FOR+OCEAN+MICROSTRUCTURE+AND+BUBBLES&rft.au=MEDWIN%2C+H%3BFitzgerald%2C+J%3BRAUTMANN%2C+G&rft.aulast=MEDWIN&rft.aufirst=H&rft.date=1975-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - MEASUREMENT OF ZOOPLANKTON BIOMASS BY CARBON ANALYSIS FOR APPLICATION IN SOUND SCATTERING MODELS AN - 19137598; 7601163 AB - ORGANIC CARBON ANALYSIS IS A SIMPLE, RELIABLE TEST OF MARINE ORGANISM (ZOOPLANKTON) BIOMASS. THE LECO CARBON ANALYZER WHICH EMPLOYS HIGH TEMPERATURE DRY COMBUSTION AND A THERMAL CONDUCTING SENSOR WAS ADAPTED FOR DETERMINING TOTAL CARBON. ANALYSIS WAS RAPID (70 SECONDS), CONSISTENT (PLUS OR MINUS 3%) CONSISTENT (PLUS OR MINUS 3%). LESS THAN 71 MG OF CARBON IN BENZOIC ACID OR CASEIN COULD BE MEASURED. BIOMASS MEASUREMENT USING CARBON ANALYSIS WAS TESTED BY DETERMINING THE CARBON CONTENT IN A MARINE COPEPOD, TIGRIOPUS CALIFORNICUS; THE MEAN CARBON CONTENT WAS 38.6% FREEZE-DRIED WEIGHT. THE MEAN ADENOSINE TRIPHOSPHATE-CARBON TO TOTAL CARBON RATIO IN T. CALIFORNICUS WAS 0.2634%; THIS WAS USED TO DETERMINE LIVING BIOMASS OF FIELD NET SAMPLES. ZOOPLANKTON WERE CONSIDERED TO BE INDIGENOUS ABOVE 200 M AND DISTRIBUTED IN PATCHES DEPENDENT ON SPACE AND TIME. ESTIMATES OF TOTAL, LIVING, AND DEAD BIOMASS BY CARBON ANALYSIS AND ATP MEASUREMENTS SHOWED DEFINITE SEASONAL TRENDS IN MONTEREY BAY, CALIFORNIA. STANDARD CURVES OF THE LECO CARBON ANALYZER SHOULD BE VERIFIED WITH OTHER STANDARDS. COLLECTION AND FREEZE-DRYING TECHNIQUES NEED TO BE IMPROVED. DIURNAL AND MULTI-DAY STUDIES ARE SUGGESTED. ACOUSTIC MEASUREMENTS SHOULD BE MADE IN THE SAME REGION TO TEST THE APPLICATION OF ZOOPLANKTON BIOMASS MEASUREMENTS TO SOUND SCATTERING. (BUCHANAN-DAVIDSON--WISCONSIN) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, SPRINGFIELD, VA 22161 AS AD/A-001 294, $5.50 IN PAPER COPY, $2.25 IN MICROFICHE. MASTER'S THESIS, SEPTEMBER 1974, 122 P. 39 FIG, 5 TAB, 45 REF. AU - Radney, J C AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1974/04// PY - 1974 DA - Apr 1974 KW - Water Resources Abstracts KW - *MEASUREMENT KW - *ZOOPLANKTON KW - *BIOMASS KW - *CARBON KW - *ANALYTICAL TECHNIQUES KW - ACOUSTICS KW - METHODOLOGY KW - SONAR KW - OCEANS KW - LECO CARBON ANALYZER KW - BENZOIC ACID KW - CASEIN KW - TIGRIOPUS CALIFORNICUS KW - MONTEREY BAY(CALIF) KW - SOUND SCATTERING KW - SW 3010:Identification of pollutants KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19137598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=MEASUREMENT+OF+ZOOPLANKTON+BIOMASS+BY+CARBON+ANALYSIS+FOR+APPLICATION+IN+SOUND+SCATTERING+MODELS&rft.au=Radney%2C+J+C&rft.aulast=Radney&rft.aufirst=J&rft.date=1974-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THE ECONOMICS OF THE WEST COAST OIL SPILL CLEAN-UP INDUSTRY AN - 19137076; 7601624 AB - THE EFFECTS OF THE GREAT FLUCTUATIONS IN DEMAND FOR COMMERICAL FIRMS IN OIL SPILL CLEAN-UP ON THE WEST COAST AS RELATED TO THEIR RETURN ON INVESTMENT AND PROFITS; THAT INDUSTRY'S VIABILITY AS AFFECTED BY CLEAN-UP SERVICE PROVIDED BY THE PRIVATE SECTOR, THE NON-PROFIT COOPERATIVE SECTOR, AND THE GOVERNMENT SECTOR; AND THE OVERLAP OF THE VARIOUS SECTORS IS DISCUSSED. THE INTERACTION OF EQUIPMENT AND PERSONNEL OF THE COMPLIMENTARY SECTORS STRENGTHEN THE NEED FOR EACH SECTOR OF THE INDUSTRY. COMMERICAL FIRMS HAVE CONCENTRATED THEIR CLEAN-UP CAPABILITY TOWARDS MINOR SPILLS DUE TO THE HIGH COST OF LARGE-SCALE EQUIPMENT REQUIRED ON MODERATE AND MAJOR SPILLS, BUT THEY CONTRIBUTE TO LARGE-SCALE CLEAN-UP INCIDENTS WITHIN LIMITS OF THEIR CAPABILITY. THE IMPACT OF DEMAND UNCERTAINTY FOR THE COMMERICAL FIRMS IS MITIGATED BY THE EXTENT OF THEIR DEPENDENCE ON CLEAN-UP ACTIVITY AS A SOURCE OF REVENUE OR WHETHER THE FIRM IS ORIENTED TO OTHER SERVICES. THE STUDY INDICATED A TREND FOR INCREASED DEPENDENCE ON OTHER THAN CLEAN-UP ACTIVITIES (MARINE-INDUSTRIAL CLEANING SERVICES, TUG AND BARGE SERVICE, AND POLLUTION PREVENTION) BY MOST OF THESE FIRMS. THE NINE FIRMS INVESTIGATED SHARED A 2.4 MILLION DOLLAR PER YEAR INDUSTRY BUT THE UNCERTAIN NATURE OF CLEAN-UP PREVENTS ANY PREDICTION OF POTENTIAL GROWTH. (AUEN-WISCONSIN) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, SPRINGFIELD, VA 22161, AS AD-A-003 860, $4.50 IN PAPER COPY, $2.25 IN MICROFICHE. MS THESIS, DECEMBER 1974. 78 P, 5 FIG, 6 TAB, 14 REF, 2 APPEND. AU - Stone, C M AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1974/04// PY - 1974 DA - Apr 1974 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *INDUSTRIES KW - *WATER POLLUTION CONTROL KW - PACIFIC COAST REGION KW - POLLUTION ABATEMENT KW - RETURN(MONETARY) KW - FINANCIAL FEASIBILITY KW - RISKS KW - FLUCTUATIONS KW - ELASTICITY OF DEMAND KW - *OIL SPILLS CLEAN-UP INDUSTRY KW - SEATTLE(WASH) KW - PORTLAND(ORE) KW - SAN FRANCISCO BAY(CALIF) KW - LOS ANGELES(CALIF) KW - LONG BEACH(CALIF) KW - SAN DIEGO(CALIF) KW - SW 4030:Cost allocation, cost sharing, pricing KW - SW 3070:Water quality control KW - SW 4020:Evaluation process UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19137076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THE+ECONOMICS+OF+THE+WEST+COAST+OIL+SPILL+CLEAN-UP+INDUSTRY&rft.au=Stone%2C+C+M&rft.aulast=Stone&rft.aufirst=C&rft.date=1974-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A STUDY OF THE BENTHIC ALGAE IN THE KELP BED OFF DEL MONTE BEACH, MONTEREY, CALIFORNIA AN - 19131380; 7601153 AB - APPROXIMATELY 50 BENTHIC ALGAL SPECIES AND ONE EEL GRASS SPECIE WERE COLLECTED AND IDENTIFIED. WHEN 13 OF THE MOST ABUNDANT AND/OR EASILY RECOGNIZED GENERA WERE CLASSIFIED INTO FIVE FLORAL GROUPS ACCORDING TO TAXONOMY AND HEIGHT AND MAPPED IF THEY WERE FOUND IN PRE-SELECTED QUADRAT SITES, ABUNDANCE OF EACH GENERA GROUP WAS LESS IN LARGE SAND COVERED SHALE AREAS, GREATER NEAR SHALE LEDGE EDGE AREAS, AND DEPENDENT ON GENERA GROUPING WHEN WITHIN MACROCYSTIS 'HOLD-FAST NEAR FIELD AREAS.' THE MEAN NUMBER OF STIPES COUNTED PER HOLDFAST DECREASED BETWEEN WINTER AND SUMMER COLLECTIONS. AERIAL PHOTOGRAPHY OVER A FIVE YEAR PERIOD REVEALED THAT THE KELP CANOPY SHOWED A SUBSTANTIAL SIZE INCREASE BETWEEN OCTOBER 1971-DECEMBER 1972. KELP BEDS NEAR THE CITY OF MONTEREY SEWER OUTFALL APPEARED TO BE RECEDING INTO DEEPER WATER FROM OCTOBER 1971-JANUARY 1974. THEORETICAL WAVE REFRACTION ENERGY COMPUTATIONS APPEARED CONSISTENT WITH THE PRESENCE OF ZOSTERA AND THE BEST DEVELOPED CYSTOSEIRA AND DICTYONEUROPSIS IN PREDICTED CALM WATER AREAS, AS WELL AS PRESENCE OF NEREOCYSTIS AND PTERYGOPHORA IN PREDICTED HIGH WAVE ENERGY AREAS. A SPECIES LIST AND THEIR ECOLOGICAL DISTRIBUTION IS APPENDED. (BUCHANAN-DAVIDSON--WISCONSIN) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, SPRINGFIELD VA 22161 AS AD/A-005 465. MS THESIS, DECEMBER 1974. 143 P, 17 FIG, 7 TAB, 22 REF, 5 APPEND. AU - Keithly, J L AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1974/04// PY - 1974 DA - Apr 1974 KW - Water Resources Abstracts KW - *MARINE ALGAE KW - *BENTHIC FLORA KW - *KELPS KW - COASTS KW - CALIFORNIA KW - VARIETIES KW - PERIPHYTON KW - DISTRIBUTION PATTERNS KW - SURVEYS KW - MAPPING KW - *DEL MONTE BEACH(CALIF) KW - *MONTEREY(CALIF) KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19131380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+STUDY+OF+THE+BENTHIC+ALGAE+IN+THE+KELP+BED+OFF+DEL+MONTE+BEACH%2C+MONTEREY%2C+CALIFORNIA&rft.au=Keithly%2C+J+L&rft.aulast=Keithly&rft.aufirst=J&rft.date=1974-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - MEASUREMENT AND ANALYSIS OF TEMPORAL VARIATIONS OF SALINITY IN SHALLOW WATER AN - 19127701; 7602542 AB - A FOUR-ELECTRODE CONDUCTIVITY INSTRUMENT WAS DEVELOPED TO DETERMINE VARIATIONS OF CONDUCTIVITY IN AN OCEAN ENVIRONMENT AT A FIXED POINT. A FIELD EXPERIMENT WAS CONDUCTED IN MISSION BAY, SAN DIEGO, CALIFORNIA. RESULTS INDICATED THAT THE INSTRUMENT FUNCTIONED PROPERLY AND ACCURATELY RESOLVED CONDUCTIVITY MICROSTRUCTURE. FROM CONDUCTIVITY AND ASSOCIATED TEMPERATURE DATA, SALINITY DATA WAS DERIVED WHICH PORTRAYS A WELL-MIXED SALINITY STRUCTURE. DIFFICULTY WITH A MISMATCH OF TIME CONSTANTS BETWEEN CONDUCTIVITY AND TEMPERATURE INSTRUMENTS PREVENTED THE ACCURATE DETERMINATION OF SALINITY MICROSTRUCTURE, ALTHOUGH THERE WAS EVIDENCE THAT ONE EXISTED. (SIMS-ISWS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, SPRINGFIELD, VA 22161 AS AD/A-003 536, $5.00 IN PAPER COPY, $2.25 IN MICROFICHE. M.S. THESIS, SEPTEMBER 1974. 80 P, 33 FIG, 2 TAB, 18 REF. AU - KANE, LKII AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1974/04// PY - 1974 DA - Apr 1974 KW - Water Resources Abstracts KW - *INSTRUMENTATION KW - *CONDUCTIVITY KW - *SALINITY KW - TEMPERATURE KW - MEASUREMENT KW - ANALYSIS KW - SHALLOW WATER KW - ON-SITE INVESTIGATIONS KW - SEA WATER KW - SALINE WATER KW - CHEMICAL PROPERTIES KW - WATER PROPERTIES KW - OCEANOGRAPHY KW - ENERGY DENSITY SPECTRA KW - SW 5040:Data acquisition KW - SW 3010:Identification of pollutants KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19127701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=MEASUREMENT+AND+ANALYSIS+OF+TEMPORAL+VARIATIONS+OF+SALINITY+IN+SHALLOW+WATER&rft.au=KANE%2C+LKII&rft.aulast=KANE&rft.aufirst=LKII&rft.date=1974-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - FORMATION AND DEVELOPMENT OF BEACH CUSPS ON DEL MONTE BEACH, MONTEREY, CALIFORNIA AN - 19127517; 7506250 AB - OBSERVATIONS AND MEASUREMENTS WERE MADE DAILY ON DEL MONTE BEACH IN ORDER TO DEVELOP A QUANTITATIVE DESCRIPTION OF THE PARAMETERS AFFECTING THE FORMATION OF BEACH CUSPS. MULTIPLE REGRESSION TECHNIQUES WERE USED TO FORMULATE AN EQUATION RELATING CUSP WIDTH TO THE MEASURED PARAMETERS. THE LIFE CYCLE OF CUSPS WAS STUDIED IN ORDER TO GAIN INSIGHT INTO THE FACTORS AFFECTING THE GROWTH AND DECAY OF CUSPS. IT WAS DETERMINED THAT CUSPS ARE DEPOSITIONAL IN NATURE AND DEVELOP SEQUENTIALLY FROM PREFERENTIAL AREAS OF ACCRETION ON THE BEACH. CUSP SPACING WAS FOUND TO BE A FUNCTION PRIMARILY OF WAVE HEIGHT (ENERGY) AND WAVE PERIOD. REGULARITY OF THE WAVE REGIME DURING FORMATION WAS FOUND TO RESULT IN UNIFORM CUSP SPACING. LITTLE MIGRATION WAS OBSERVED IN MATURE CUSPS, AND LARGE CHANGES IN THE WAVE REGIME OR BEACH CONDITIONS WERE REQUIRED TO ALTER THE CUSP PROFILES. THE ACTION OF LARGE WIND WAVES, STORM SURGES, AND BREAKERS WAS OBSERVED TO DESTROY BEACH CUSPS. (SIMS-ISWS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, SPRINGFIELD, VA 22161 AS AD-787 376, $4.25 IN PAPER COPY, $2.25 IN MICROFICHE. MS THESIS, SEPTEMBER 1974. 66 P, 18 FIG, 3 TAB, 24 REF. AU - Bodie, J G AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1974/04// PY - 1974 DA - Apr 1974 KW - Water Resources Abstracts KW - *BEACHES KW - *WAVES(WATER) KW - *DEPOSITION(SEDIMENTS) KW - *CALIFORNIA KW - SANDS KW - SEASHORES KW - BAYS KW - SURF KW - OCEAN WAVES KW - GEOMORPHOLOGY KW - ON-SITE INVESTIGATIONS KW - REGRESSION ANALYSIS KW - *BEACH CUSPS KW - BEACH MORPHOLOGY KW - DEL MONTE BEACH(CALIF) KW - MONTEREY(CALIF) KW - SW 0870:Erosion and sedimentation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19127517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=FORMATION+AND+DEVELOPMENT+OF+BEACH+CUSPS+ON+DEL+MONTE+BEACH%2C+MONTEREY%2C+CALIFORNIA&rft.au=Bodie%2C+J+G&rft.aulast=Bodie&rft.aufirst=J&rft.date=1974-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THE KINEMATICS OF WATER PARTICLE OF BREAKING WAVES WITHIN THE SURF ZONE AN - 19123907; 7410409 AB - SIMULTANEOUS MEASUREMENTS OF WAVES, AND VERTICAL AND HORIZONTAL WATER PARTICLE VELOCITIES WERE MADE AT THE BREAKER LINE WITHIN THE SURF ZONE USING A CAPACITANCE TYPE PENETRATING WAVE STAFF, A PRESSURE WAVE GAGE, AND AN ELECTROMAGNETIC CURRENT METER. WAVE MEASUREMENTS WERE ALSO MADE AT SEAWARD AND SHOREWARD LOCATIONS. THE WAVE ENERGY-DENSITY SPECTRAL COMPONENTS WERE CONVERTED TO VELOCITY SPECTRAL COMPONENTS USING LINEAR WAVE THEORY. THESE COMPUTED VALUES COMPARED WELL QUALITATIVELY WITH THE MEASURED VELOCITY SPECTRA. LINEAR THEORY UNDERPREDICTED WAVE-INDUCED HORIZONTAL VELOCITY SPECTRAL COMPONENTS BY ABOUT 50% AT THE FREQUENCY OF PEAK ENERGY. THE COHERENCE VALUES BETWEEN WAVES AND HORIZONTAL VELOCITY WERE HIGH, RANGING ABOVE 0.75. THE PHASE ANGLE COMPUTATION SHOWED THE CALCULATED VELOCITY COMPONENTS LEADING THE MEASURED VELOCITY COMPONENTS BY AN AVERAGE OF 20 DEGREES, INDICATING AN UNSTABLE WAVE CREST LEADING THE PARTICLE MOTION IN THE BODY OF THE WAVE. PROBABILITY DENSITY FUNCTIONS WERE COMPUTED AND COMPARED TO GAUSSIAN AND GRAM-CHARLIER DISTRIBUTIONS USING THE CHI-SQUARE GOODNESS-OF-FIT TEST. THE GRAM-CHARLIER DISTRIBUTION QUALITATIVELY GAVE THE BETTER FIT TO THE DATA. (KNAPP-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA 22161 AS AD-773 754, PRICE $3.25 PRINTED COPY; $2.25 MICROFICHE. TECHNICAL REPORT NPS-58TM74011A, JANUARY 1974. 34 P, 12 FIG, 1 TAB, 12 REF. AU - Thornton, E B AU - Richardson, D P AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1974/04// PY - 1974 DA - Apr 1974 KW - Water Resources Abstracts KW - *WAVES(WATER) KW - *SURF KW - CURRENTS(WATER) KW - TURBULENCE KW - VELOCITY KW - STATISTICAL METHODS KW - SW 0835:Streamflow and runoff KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19123907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THE+KINEMATICS+OF+WATER+PARTICLE+OF+BREAKING+WAVES+WITHIN+THE+SURF+ZONE&rft.au=Thornton%2C+E+B%3BRichardson%2C+D+P&rft.aulast=Thornton&rft.aufirst=E&rft.date=1974-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - AN EXAMINATION OF ALTERNATIVE METHODS FOR EMPLOYING BOOMS TO CONTAIN OIL SPILLS IN NAVY HARBORS AN - 19115343; 7504720 AB - ONE PORTION OF THE POLLUTION PROBLEM WAS ADDRESSED, THAT IS, METHODS OF EMPLOYING BOOMS TO CONTAIN OIL SPILLS IN HARBORS CONTROLLED BY THE U.S. NAVY. CONTAINMENT OF A SPILL IS AN ESSENTIAL STEP IN THE PROCESS OF CLEANING UP A SPILL AND REDUCING POLLUTION. A PLAN WAS FORMULATED WHICH WILL ENABLE A DECISION MAKER TO EVALUATE AND RANK THREE DIFINED METHODS FOR DEPLOYING OIL SPILL CONTAINMENT BOOM. THE PLAN IS BASED ON A UTILITY ANALYSIS OF EACH METHOD, WITH A DECISION ANALYSIS TECHNIQUE TO DETERMINE THE RELATIVE IMPORTANCE OF VARIOUS PARAMETERS EFFECTING THE UTILITY OF EACH METHOD. ALTHOUGH THESE PARAMETERS ARE RELATED, THEY ARE INDEPENDENT AND CAN BE CONSIDERED INDIVIDUALLY. THE PLAN IDENTIFIES THE DATA THAT MUST BE OTAINED AND DEMONSTRATES A METHOD FOR ORGANIZING AND MANIPULATING THE DATA. THIS PLAN CAN BE OF ASSISTANCE TO THE DECISION MAKER IN DETERMINING AN OPTIMUM METHOD FOR BOOM EMPLOYMENT AT EACH NAVAL ACTIVITY AND THEN DETERMINING CONTAINMENT DEVICE PROCUREMENT REQUIREMENTS. (SIMS-ISWS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, SPRINGFIELD, VA. 22161, AS AD-783 790, $5.25 IN PAPER COPY, $2.25 IN MICROFICHE. MS THESIS, P 101, JUNE 1974. 13 FIG, 35 REF, 5 APPEND. AU - Larson, J J AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1974/04// PY - 1974 DA - Apr 1974 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *WATER POLLUTION CONTROL KW - *ALTERNATIVE PLANNING KW - *POLLUTION ABATEMENT KW - DECISION MAKING KW - EVALUATION KW - OIL POLLUTION KW - COST-BENEFIT ANALYSIS KW - HARBORS KW - *FLOATING BARRIERS KW - *CONTAINMENT BOOMS KW - ALTERNATIVE METHODS KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19115343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=AN+EXAMINATION+OF+ALTERNATIVE+METHODS+FOR+EMPLOYING+BOOMS+TO+CONTAIN+OIL+SPILLS+IN+NAVY+HARBORS&rft.au=Larson%2C+J+J&rft.aulast=Larson&rft.aufirst=J&rft.date=1974-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - EXPERIMENTS SUPPORTING A PROGRAM OF WARM FOG DISPERSAL BY ELECTRICAL CHARGE INJECTION AN - 19097795; 7413216 AB - FOG CLEARING BY INJECTION OF ELECTRICAL CHARGES INTO THE FOG WAS STUDIED BY EXPERIMENTS MADE TO DETERMINE THE CHARGE TRANSFERRED TO WATER SPRAYS. CONTACT CHARGING MECHANISMS WERE AS MUCH AS 1 MILLION TIMES AS EFFECTIVE AS INDUCTION CHARGING MECHANISMS. THE CHARGE ON SOAP FILM BUBBLES WAS MEASURED. FOR A 2-INCH BUBBLE FORMED AT 30 KV THE CHARGE WAS ON THE ORDER OF 1 MICROCOULOMB. TESTS OF FOG CLEARING IN AN ENVIRONMENTAL CHAMBER INDICATED FAIR RESULTS WITH WATER SPRAY TECHNIQUES AND MUCH BETTER RESULTS WITH TECHNIQUES BY WHICH CHARGE IS INJECTED DIRECTLY INTO THE ATMOSPHERE (CORONA INJECTION). PRELIMINARY TESTS OF CORONA INJECTION INTO THE ATMOSPHERE SHOWED THAT CONSIDERABLE CHARGE ATTACHED TO WINDBORNE PARTICLES. (KNAPP-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA 22161 AS AD-775 911, PRICE $3.75 PRINTED COPY; $2.25 MICROFICHE. REPORT NPS-6 SQRC74011 (FINAL REPORT FOR PERIOD JANUARY 1973-JANUARY 1974), JANUARY 28, 1974. 39 P, 6 FIG, 3 TAB, APPEND. AU - Schacher, Ge AU - Reese, W AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1974/04// PY - 1974 DA - Apr 1974 KW - Water Resources Abstracts KW - *FOG KW - *WEATHER MODIFICATION KW - *ELECTRICAL STUDIES KW - CLOUD PHYSICS KW - ELECTRICAL CORONAS KW - EXTRA HIGH VOLTAGE KW - *FOG CLEARING KW - *FOG DISPERSAL KW - SW 0815:Precipitation KW - SW 1020:Water yield improvement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19097795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=EXPERIMENTS+SUPPORTING+A+PROGRAM+OF+WARM+FOG+DISPERSAL+BY+ELECTRICAL+CHARGE+INJECTION&rft.au=Schacher%2C+Ge%3BReese%2C+W&rft.aulast=Schacher&rft.aufirst=Ge&rft.date=1974-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - ANTIFOULING COATINGS AND THEIR INFLUENCE ON THE MARINE ENVIRONMENT AN - 19151805; 7610365 AB - CURRENTLY USED ANTIFOULING COATINGS OWE THEIR EFFECTIVENESS TO THE RELEASE OF THE IONS OF HEAVY METALS INTO THE SEA WATER SURROUNDING THE SURFACE PROTECTED BY THE COATINGS. THESE IONS CAN CONTRIBUTE SIGNIFICANTLY TO THE CONCENTRATION OF HEAVY METALS IN THE SURROUNDING SEA WATER AND CAN POSE A THREAT TO THE MARINE ENVIRONMENT. NEW TECHNIQUES THAT DO NOT DEPEND ON TOXIC CHEMICAL FORMULATIONS MUST BE DEVELOPED TO PREVENT FOULING ON SHIPS' HULLS AND OTHER SUBMERGED STRUCTURES. (SEE ALSO W76-10353) (KATZ) JF - IN: PROCEEDINGS OF THE CONFERENCE ON MARINE BIOLOGY IN ENVIRONMENTAL PROTECTION, HELD AT SAN CLEMENTE ISLAND, CALIFORNIA, ON 13-15 NOVEMBER, 1973 DECEMBER, 1974, P 139-145, 6 REF. AU - Haderlie, E C AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1974/03// PY - 1974 DA - Mar 1974 KW - Water Resources Abstracts KW - *HEAVY METALS KW - *TOXICITY KW - *PERIPHYTON KW - *FOULING KW - SHIPS KW - AQUATIC ALGAE KW - NUISANCE ALGAE KW - IONS KW - CRUSTACEANS KW - WATER POLLUTION CONTROL KW - SW 3070:Water quality control KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19151805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=ANTIFOULING+COATINGS+AND+THEIR+INFLUENCE+ON+THE+MARINE+ENVIRONMENT&rft.au=Haderlie%2C+E+C&rft.aulast=Haderlie&rft.aufirst=E&rft.date=1974-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THE KINEMATICS OF WATER PARTICLE VELOCITIES OF BREAKING WAVES WITHIN THE SURF ZONE AN - 19091568; 7406314 AB - SIMULTANEOUS MEASUREMENTS OF WAVES, AND VERTICAL AND HORIZONTAL WATER PARTICLE VELOCITIES WERE MADE AT THE BREAKER-LINE WITHIN THE SURF ZONE USING A CAPACITANCE TYPE PENETRATING WAVE STAFF, A PRESSURE WAVE GAUGE, AND AN ELECTROMAGNETIC CURRENT METER. WAVE MEASUREMENTS WERE ALSO MADE AT SEAWARD AND SHOREWARD LOCATIONS. THE WAVE ENERGY-DENSITY SPECTRAL COMPONENTS WERE CONVERTED TO VELOCITY SPECTRAL COMPONENTS USING LINEAR WAVE THEORY. THESE COMPUTED VALUES COMPARED WELL QUALITATIVELY WITH THE MEASURED VELOCITY SPECTRA. QUANTITATIVELY, THE RESULTS SHOWED THAT LINEAR THEORY UNDERPREDICTED WAVE-INDUCED HORIZONTAL VELOCITY SPECTRAL COMPONENTS BY ABOUT 50 PERCENT AT THE FREQUENCY OF PEAK ENERGY. THE COHERENCE VALUES BETWEEN WAVES AND HORIZONTAL VELOCITY WERE HIGH, RANGING ABOVE 0.75. THE PHASE ANGLE COMPUTATION SHOWED THE CALCULATED VELOCITY COMPONENTS LEADING THE MEASURED VELOCITY COMPONENTS BY AN AVERAGE OF 20 DEGREES, INDICATING AN UNSTABLE WAVE CREST LEADING THE PARTICLE MOTION IN THE BODY OF THE WAVE. PROBABILITY DENSITY FUNCTIONS WERE COMPUTED AND COMPARED TO GAUSSIAN AND GRAM-CHARLIER DISTRIBUTIONS USING THE CHI-SQUARE GOODNESS-OF-FIT TEST. THE GRAM-CHARLIER DISTRIBUTION QUALITATIVELY GAVE THE BETTER FIT TO THE DATA. (SINHA - OEIS) JF - AVAILABLE FROM NTIS AS AD-769 423 FOR $5.00 IN PAPER COPY. MASTER'S THESIS, SEPTEMBER 1973. 55 P, 19 FIG, 1 TAB, 12 REF. AU - Richardson, D P AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1973/09// PY - 1973 DA - Sep 1973 KW - Water Resources Abstracts KW - *WAVES(WATER) KW - *SURF KW - MEASUREMENT KW - OCEAN WAVES KW - PARTICLE MOTION KW - *PARTICLE VELOCITIES KW - PROBABILITY DENSITY FUNCTIONS KW - *WAVE MEASUREMENTS KW - *LINEAR WAVE THEORY KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19091568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THE+KINEMATICS+OF+WATER+PARTICLE+VELOCITIES+OF+BREAKING+WAVES+WITHIN+THE+SURF+ZONE&rft.au=Richardson%2C+D+P&rft.aulast=Richardson&rft.aufirst=D&rft.date=1973-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - ORIGIN AND DEVELOPMENT OF BEACH CUSPS AT MONTEREY BAY, CALIFORNIA AN - 19090248; 7406313 AB - BEACH CUSPS WERE OBSERVED DAILY ON DEL MONTE BEACH, CALIFORNIA, AND MEASUREMENTS OBTAINED SO THAT A QUANTITATIVE DESCRIPTION OF THE PARAMETERS WHICH AFFECT FORMATION AND SIZE OF CUSPS COULD BE DETERMINED. IN ADDITION A THEORY OF CUSP FORMATION WAS FORMULATED AND AN INSIGHT OBTAINED INTO THE FACTORS WHICH INFLUENCE THE SHAPE AND SIZE OF CUSPS THROUGHOUT THEIR LIFETIME. FINALLY, THE EVENTS LEADING TO CUSP DESTRUCTION WERE EXAMINED. IT WAS DETERMINED THAT BEACH CUSPS ARE DEPOSITIONAL IN NATURE, FORMING MOST EASILY IN COARSE, LOOSE, SEDIMENT. CUSP DEVELOPMENT COMMENCES AT A RISE OR AREA OF ACCRETION ON THE BEACH. A SERIES OF BEACH CUSPS FORMS SEQUENTIALLY RATHER THAN SIMULTANEOUSLY. THE WIDTH OF BEACH CUSPS ARE A FUNCTION OF WAVE HEIGHT; THE LARGER WAVES PRODUCING WIDER CUSP SPACING. UNIFORM SPACING OF CUSPS IN A SERIES CAN BE ATTRIBUTED TO THE SAME SIZE WAVES STRIKING THE BEACH DURING THE FORMATION PERIOD OF THE CUSPS. ONCE FORMED, CUSPS ARE STABLE AND TEND TO MAINTAIN THEIR DIMENSIONS UNLESS A LARGE CHANGE IN WAVE OR BEACH CONDITION OCCURS. (SINHA - OEIS) JF - AVAILABLE FROM NTIS AS AD-769 672 FOR $5.50 IN PAPER COPY. MASTER'S THESIS, SEPTEMBER 1973. 63 P, 13 FIG, 3 TAB, 20 REF. AU - Smith, D H AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1973/09// PY - 1973 DA - Sep 1973 KW - Water Resources Abstracts KW - *EROSION KW - *DEPOSITION KW - *BEACHES KW - CALIFORNIA KW - BEACH EROSION KW - *BEACH CUSPS KW - *CUSP FORMATION KW - SEDIMENT SIZE KW - MONTEREY(CALIF.) KW - *WAVE HEIGHT KW - BREAKER ANGLE KW - BEACH SLOPE KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19090248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=ORIGIN+AND+DEVELOPMENT+OF+BEACH+CUSPS+AT+MONTEREY+BAY%2C+CALIFORNIA&rft.au=Smith%2C+D+H&rft.aulast=Smith&rft.aufirst=D&rft.date=1973-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - LABORATORY INVESTIGATION OF ELECTRICAL DISSIPATION OF WARM FOG AN - 19113274; 7410623 AB - FOG CLEARING BY ELECTRICAL MEANS WAS STUDIED IN A 27-CUBIC-FOOT FOG CHAMBER. FOGGING OF THE CHAMBER WAS ACCOMPLISHED WITH A SPRAY NOZZLE DRIVEN BY PRE-HUMIDIFIED AIR, PRODUCING WATER DROPLETS RANGING FROM 10 TO 75 MICROMETERS. A CORONA DISCHARGE HEAD IN THE CENTER OF THE CHAMBER WAS OPERATED FROM 0 TO 100 KV AND MEASUREMENTS OF FOG CONDITIONS WERE MADE OPTICALLY AND WITH COATED SLIDES PLACED AT VARIOUS POSITIONS IN THE CHAMBER. RAPID CLEARING WAS CAUSED BY THE CORONA DISCHARGE. THE DOMINANT CLEARING MECHANISMS IDENTIFIED WERE COALESCENCE AND PUSHING OF CHARGED DROPLETS TO THE WALLS OF THE CHAMBER; THE SMALL SIZE OF THE CHAMBER PRECLUDED DETERMINATION OF WHICH MECHANISM WOULD BE MOST IMPORTANT IN LARGE-SCALE FOG CLEARING. (KNAPP-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA 22161 AS AD-775 029 PRICE $7.75 PRINTED COPY; $2.25 MICROFICHE. M SC THESIS, DECEMBER 1973. 90 P, 15 FIG, 4 TAB, 46 REF, 2 APPEND. AU - Herman, L B AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1973/04// PY - 1973 DA - Apr 1973 KW - Water Resources Abstracts KW - *FOG KW - *WEATHER MODIFICATION KW - *ELECTRICAL STUDIES KW - *ELECTRICAL CORONAS KW - CLOUD PHYSICS KW - LABORATORY TESTS KW - FOG CLEARING KW - SW 0815:Precipitation KW - SW 1020:Water yield improvement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19113274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=LABORATORY+INVESTIGATION+OF+ELECTRICAL+DISSIPATION+OF+WARM+FOG&rft.au=Herman%2C+L+B&rft.aulast=Herman&rft.aufirst=L&rft.date=1973-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - AN INVESTIGATION OF SECONDARY FLOW EFFECTS IN CURVED CHANNELS OF SQUARE CROSS SECTION AN - 19109028; 7409193 AB - TURBULENT FLOW IN A CURVED CHANNEL OF SQUARE CROSS SECTION WAS INVESTIGATED EXPERIMENTALLY TO DETERMINE SECONDARY FLOW EFFECTS. PROBE SURVEYS WERE CONDUCTED TO ESTABLISH VORTEX AND TOTAL PRESSURE LOSS DISTRIBUTION IN THE EXIT PLANE OF A 90 DEG BEND. OVERALL LOSSES WERE DETERMINED BY MEASURING THE MOMENTUM OF THE FLOW WITH A FORCE PLATE FOR DIFFERENT REYNOLDS NUMBERS AT TURNING ANGLES OF 0, 45, 90, AND 135 DEG. THERE IS A DEFINITE INCREASE IN THE AVERAGE TOTAL LOSS COEFFICIENT WITH TURNING ANGLE. (KNAPP-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA. 22151 AS AD-764 502 PRICE $5.50 PRINTED COPY; $1.45 MICROFICHE. M SC THESIS, JUNE 1973. 63 P, 30 FIG, 1 TAB, 3 REF. AU - Kenney, P S AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1973/04// PY - 1973 DA - Apr 1973 KW - Water Resources Abstracts KW - *OPEN CHANNEL FLOW KW - *VORTICES KW - MEANDERS KW - TURBULENT FLOW KW - HYDRAULIC MODELS KW - CHANNEL MORPHOLOGY KW - *SECONDARY FLOW KW - SW 6020:Hydraulics KW - SW 0835:Streamflow and runoff UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19109028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=AN+INVESTIGATION+OF+SECONDARY+FLOW+EFFECTS+IN+CURVED+CHANNELS+OF+SQUARE+CROSS+SECTION&rft.au=Kenney%2C+P+S&rft.aulast=Kenney&rft.aufirst=P&rft.date=1973-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - MEASUREMENT OF VISCOELASTIC PROPERTIES OF SOME RECENT MARINE SEDIMENTS BY A TORSIONALLY OSCILLATING CYLINDER METHOD AN - 19107523; 7500223 AB - THE VISCOELASTIC PROPERTIES OF 13 MARINE SAMPLES COLLECTED BY SHIPEK GRAB FROM SHALLOW WATER REGIONS OF MONTEREY BAY, CALIFORNIA WERE MEASURED USING A TORSIONALLY OSCILLATING CYLINDRICAL PROBE OPERATING IN THE FREQUENCY RANGE OF 0.8 TO 3.3 KHZ. OTHER MASS PHYSICAL PROPERTIES SUCH AS WET DENSITY, POROSITY, SOUND SPEED, SAND-SILT-CLAY-GRAVEL PERCENTAGES, MEAN GRAIN SIZE AND SORTING WERE ALSO MEASURED. LIMITED PRECISION OF IMPEDANCE MEASUREMENTS PERMITTED ONLY THE DETERMINATION OF THE MECHANICAL RESISTANCE DUE TO THE PROBE CONTACT WITH THE SEDIMENT. CORRELATIONS BETWEEN MECHANICAL RESISTANCE AND MASS PHYSICAL PROPERTIES WERE STUDIED BY GRAPHICAL MEANS. WATER CONTENT OF SEDIMENTS IS A DETERMINING FACTOR IN THE MECHANICAL RESISTANCE OF A SEDIMENT. A DEPENDENCE OF MECHANICAL RESISTANCE UPON FREQUENCY WAS OBSERVED. (KNAPP-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA 22161 AS AD-769 417, PRICE $4.75 PRINTED COPY; $2.25 MICROFICHE. M SC THESIS, NAVAL POSTGRADUATE SCHOOL, SEPTEMBER 1973. 79 P, 39 FIG, 8 TAB, 11 REF. AU - Kramer, S B AD - NAVAL POSTGRADUATE SCHOOL, MONTEPY&_CALIF Y1 - 1973/04// PY - 1973 DA - Apr 1973 KW - Water Resources Abstracts KW - *SEISMIC STUDIES KW - *BOTTOM SEDIMENTS KW - *MECHANICAL PROPERTIES KW - *VISCOSITY KW - *ELASTICITY(MECHANICAL) KW - *CALIFORNIA KW - PARTICLE SIZE KW - SEDIMENT SORTING KW - SANDS KW - SILTS KW - CLAYS KW - POROSITY KW - DENSITY KW - SEDIMENTOLOGY KW - SONOR KW - SOUNDING KW - SOUND WAVES KW - MONTEREY BAY(CALIF) KW - SW 6040:Soil mechanics KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19107523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=MEASUREMENT+OF+VISCOELASTIC+PROPERTIES+OF+SOME+RECENT+MARINE+SEDIMENTS+BY+A+TORSIONALLY+OSCILLATING+CYLINDER+METHOD&rft.au=Kramer%2C+S+B&rft.aulast=Kramer&rft.aufirst=S&rft.date=1973-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SHALLOW WATER EXPERIMENT UTILIZING THE STD MODEL 9006 AT A FIXED POINT AN - 19087339; 7406317 AB - THE SALINITY SENSING CAPABILITIES OF THE STD MODEL 9006 WERE EXAMINED IN LABORATORY AND IN SHALLOW WATER FIELD CONDITIONS BOTH IN MONTEREY BAY AND AT THE N.U.C. TOWER OFF MISSION BEACH AT SAN DIEGO, CALIFORNIA. LABORATORY STUDIES SHOWED IT TO BE INFLUENCED BY CHANGES IN WATER VELOCITY FROM ZERO TO NON-ZERO. FIELD STUDIES SHOWED THAT THE INSTRUMENT WAS UNSUITABLE FOR SENSING INSTANTANEOUS MICROSTRUCTURE FLUCTUATIONS OF SALINITY IN SHALLOW WATER WHILE BEING HELD AT A SINGLE DEPTH IN A WAVE INFLUENCED REGIME. AVERAGED OVER A PERIOD OF TEN SECONDS OR MORE, HOWEVER, THE OUTPUT OF THE INSTRUMENT WAS JUDGED TO BE ACCURATE TO AT LEAST THE FIRST DECIMAL PLACE. (SINHA - OEIS) JF - AVAILABLE FROM NTIS AS AD-769 408 FOR $6.25 IN PAPER COPY. MASTER'S THESIS, MARCH 1973. 79 P, 5 FIG, 7 TAB, 11 REF, 4 APPEND. AU - Frigge, W J AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1973/03// PY - 1973 DA - Mar 1973 KW - Water Resources Abstracts KW - *SALINITY KW - *INSTRUMENTATION KW - *COMPUTER PROGRAMS KW - CALIFORNIA KW - SHALLOW WATER KW - MEASUREMENT KW - *STD MODEL 9006 KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19087339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SHALLOW+WATER+EXPERIMENT+UTILIZING+THE+STD+MODEL+9006+AT+A+FIXED+POINT&rft.au=Frigge%2C+W+J&rft.aulast=Frigge&rft.aufirst=W&rft.date=1973-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - GRADIENT ANALYSIS OF CARBON MONOXIDE AND METHANE IN POLLUTED AND OTHER NEARSHORE HABITATS AN - 19077544; 7407984 AB - TWO CONCEPTS WERE TESTED IN MONTEREY BAY, CALIFORNIA. (1) THAT CARBON MONOXIDE PRODUCTION MIGHT BE RELATED TO PRIMARY PRODUCTIVITY AND (2) SINCE METHANE GAS, REPORTED AS PRESENT IN SURFACE WATERS, IS A PRODUCT OF ANAEROBIC DECOMPOSITION OF ORGANIC MATTER, IT MIGHT BE USEFUL AS A POLLUTION TRACER FROM SEWAGE OUTFALLS. THE HIGHLY SENSITIVE METHODS OF GAS CHROMATOGRAPHY WERE USED AND ARE DESCRIBED. RESULTS FROM AN OPEN OCEAN STATION AND SEVERAL NEARSHORE STATIONS SHOW A POSSIBLE CORRELATION BETWEEN CARBON MONOXIDE AND PRIMARY PRODUCTIVITY. METHANE WAS SHOWN TO BE PRESENT IN THE UPPER 100 M, WITH A MAXIMUM AT ABOUT 50 M. AT NEARSHORE STATIONS, CONCENTRATIONS OF METHANE AND CARBON MONOXIDE WERE BOTH FAR ABOVE EQUILIBRIUM AND OPEN OCEAN VALUES. METHANE CONCENTRATIONS WERE HIGHEST IN THE VICINITY OF SEWAGE OUTFALLS AND THE SOURCE OF THIS GAS MAY BE THE CITY WATER SUPPLY. CARBON MONOXIDE CONCENTRATIONS MAY BE DEPENDENT ON THE TYPE OF PLANT LIFE IN THE SURROUNDING WATERS. TRANSECTS SHOWED THAT METHANE WAS AN EFFECTIVE TRACER FOR SEWAGE DISPOSAL PLANT EFFLUENT AND THAT KELP SEEMED TO SLOW POLLUTANT DIFFUSION AND MIXING. RESULTS INDICATE THAT, AT LEAST LOCALLY, THE OCEAN IS A SOURCE OF CARBON MONOXIDE AND METHANE IN THE ATMOSPHERE. (JONES-WISCONSIN) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-76-4482, $6.25 IN PAPER COPY, $1.45 IN MICROFICHE. THESIS, MARCH 1973. 84 P. 19 FIG, 11 TAB, 17 REF, 3 APPEND. AU - Welch, J T AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1973/03// PY - 1973 DA - Mar 1973 KW - Water Resources Abstracts KW - *ANALYTICAL TECHNIQUES KW - *GASES KW - *METHANE KW - *SEA WATER KW - GAS CHROMATOGRAPHY KW - CALIFORNIA KW - TRACERS KW - SEWAGE EFFLUENTS KW - AIR-WATER INTERFACES KW - COMPUTER PROGRAMS KW - *CARBON MONOXIDE KW - MONTEREY BAY(CALIF.) KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19077544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=GRADIENT+ANALYSIS+OF+CARBON+MONOXIDE+AND+METHANE+IN+POLLUTED+AND+OTHER+NEARSHORE+HABITATS&rft.au=Welch%2C+J+T&rft.aulast=Welch&rft.aufirst=J&rft.date=1973-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THE DEVELOPMENT OF EUROPEAN REGIONAL LAW OF THE SEA AN - 19134476; 7512220 AB - THE DEVELOPMENT OF REGIONAL LAW OF THE SEA MAY BE MORE PRACTICAL THAN A NEW GLOBAL ORDER FOR THE OCEANS AND MAY BE PREFERABLE TO THE EXTENSION OF NATIONAL MARITIME JURISDICTIONS. THE COMMON MARKET HAS TAKEN TWO IMPORTANT STEPS TOWARD CREATING A EUROPEAN SYSTEM OF MARITIME LAW--THE EUROPEAN ECONOMIC COMMUNITY (EEC) COMMON FISHERIES POLICY AND THE EEC COMMISSION'S DECISION APPLYING THE TREATY OF ROUE AND EEC REGULATIONS TO THE CONTINENTAL SHELF. THE FORMER OPENED NATIONAL TERRITORIAL WATERS WITHIN THE EEC TO ALL COMMUNITY FISHERMEN AND PROVIDED THE FOUNDATION FOR THE GENERATION OF COMMON MARKET FISHING POLICY. THE LATTER BROUGHT THE EXPLORATION AND EXPLOITATION OF HYDROCARBONS ON THE SHELF WITHIN EEC REGULATIONS AND SUPERVISION. OTHER EUROPEAN ORGANIZATIONS (THE BOW GROUP, THE COUNCIL OF EUROPE, AND THE WESTERN EUROPEAN UNION) HAVE PROPOSED VARIOUS NON-EEC REGIMES FOR MARITIME LEGISLATION AND COOPERATION, BUT NO NON-EEC PROPOSAL SEEMS LIKELY TO BE IMPLEMENTED. THE FUTURE OF EUROPEAN LAW OF THE SEA LIES WITH THE COMMON MARKET WHICH CAN MAKE AN IMPORTANT CONTRIBUTION TO EUROPEAN MARITIME ORDER. IF A EUROPEAN SOLUTION TO MARITIME PROBLEMS IS NOT THE GLOBAL SOLUTION, IT IS STILL A MODEL OF REGIONAL COOPERATION FOR OTHER AREAS OF THE GLOBE. (GAGLIARDI-FLORIDA) JF - OCEAN DEVELOPMENT AND INTERNATIONAL LAW JOURNAL, VOL 1, P 275-289 (1973). 15 P, 1 TAB, 34 REF. AU - Janis, M W AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1973 PY - 1973 DA - 1973 KW - Water Resources Abstracts KW - *SEA WATER KW - *OCEANS KW - *INTERNATIONAL LAW KW - *EUROPE KW - INTERNATIONAL WATERS KW - INTERNATIONAL COMMISSIONS KW - FISHERIES KW - FISHING KW - FISH KW - TREATIES KW - CONTINENTAL SHELF KW - WATER KW - REGIME KW - COASTAL WATERS KW - INTERNATIONAL AGREEMENTS KW - TERRITORIAL WATERS KW - SW 4050:Water law and institutions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19134476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THE+DEVELOPMENT+OF+EUROPEAN+REGIONAL+LAW+OF+THE+SEA&rft.au=Janis%2C+M+W&rft.aulast=Janis&rft.aufirst=M&rft.date=1973-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - STUDY OF TIME VARIABILITY OF SURFACE CURRENTS AT A POINT IN MONTEREY BAY AN - 19093000; 7402692 AB - THE GEOMAGNETIC ELECTROKINETOGRAPH (GEK) WAS USED TO MEASURE SURFACE CURRENTS NEAR THE CENTER OF MONTEREY BAY DURING SIX SEPARATE 24-HOUR PERIODS FROM MAY THROUGH JULY, 1972. AN AVERAGE OF 244 CURRENT VECTORS WERE DERIVED FOR EACH CRUISE. THE MEAN CURRENTS FROM THESE CRUISES ARE ALL SOUTHERLY AND RANGED FROM 4.1 CM/SEC TO 20.4 CM/SEC. THE AVERAGE OF THESE MEAN CURRENTS IS 12.1 CM/SEC TOWARD 163T. THESE VALUES WERE COMPARED WITH INDIVIDUAL CURRENTS DERIVED FROM DYNAMIC TOPOGRAPHIES FROM THE SAME PERIOD. DIURNAL AND SEMI-DIURNAL VARIATIONS OF THE CURRENT WERE STUDIED AFTER SUBJECTING THE DATA TO A FOURIER ANALYSIS. IT WAS CONCLUDED THAT THERE MUST BE AT LEAST AN INDIRECT COUPLING OF THE OCEAN CURRENTS WITH THE SEMI-DIURNAL TIDE AT THE DATA POINT. THE DIURNAL COMPONENT ALSO IS IMPORTANT; IT MAY BE TIDAL OR INERTIAL, OR MERELY RELATED TO THE PASSAGE OF THE SUN. (SINHA-OEIS) JF - AVAILABLE FROM NTIS AS AD-756 574, $3.00 IN PAPER COPY. MSC THESIS, DECEMBER 1972. 114 P, 46 FIG, 2 TAB, 17 REF, 3 APPEND. AU - Howton, H M AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/12// PY - 1972 DA - Dec 1972 KW - Water Resources Abstracts KW - *BAYS KW - *CURRENTS(WATER) KW - *CALIFORNIA KW - *DIURNAL KW - *DATA COLLECTIONS KW - *SEASONAL KW - TIDES KW - WINDS KW - COMPUTER PROGRAMS KW - *MONTEREY BAY(CALIF) KW - SURFACE CURRENTS KW - TIME VARIABILITY KW - COUPLING KW - AIR-SEA INTERACTIONS KW - SW 5080:Evaluation, processing and publication KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19093000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=STUDY+OF+TIME+VARIABILITY+OF+SURFACE+CURRENTS+AT+A+POINT+IN+MONTEREY+BAY&rft.au=Howton%2C+H+M&rft.aulast=Howton&rft.aufirst=H&rft.date=1972-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - METHODS FOR ASSESSING VARIABILITY, WITH EMPHASIS ON SIMULATION DATA INTERPRETATIONS AN - 19075330; 7312274 AB - THE PROBLEM OF ASSESSING AND COMPARING THE VARIABILITY OF COMPLEX FUNCTIONS OF RANDOM VARIABLE REALIZATIONS IS IMPORTANT IN MANY APPLIED AREAS, INCLUDING HYDROLOGY. DIFFICULTIES STEM FROM NON-ROBUSTNESS: FOR EXAMPLE, THE USUAL (NORMAL DISTRIBUTION BASED) CONFIDENCE LIMITS FOR VARIANCES BASED ON THE CHI-SQUARED STATISTIC OFTEN TURN OUT TO BE NARROW (NON-CONSERVATIVE) AND THUS TO FALSELY OVERSTATE CONFIDENCE WHEN DATA IS NON-NORMAL. PROMISING RESULTS ARE DESCRIBED OF SOME EXPLORATORY SIMULATIONS TO EVALUATE THE SMALL-SAMPLE CHARACTERISTICS OF NEW VARIANCE (AND ALSO MEAN) ESTIMATES. INVESTIGATED IS THE PERFORMANCE OF ONE USEFUL METHOD, THE 'JACKKNIFE' OF QUENOUILLE AND TUKEY, FOR SETTING CONFIDENCE LIMITS ON THE VARIANCE OR STANDARD DEVIATION OF AN UNKNOWN DISTRIBUTION. BY USING EMPIRICAL SAMPLING EMPLOYING A COMPUTER, IT IS SHOWN THAT THE JACKKNIFE METHOD SEEMS TO BE AN IMPROVEMENT UPON NORMAL-THEORY METHODS. FINALLY, THE PERFORMANCE OF THE JACKKNIFE METHOD FOR ANLYZING A STOCHASTIC SIMULATION EXPERIMENT IS DISCUSSED. THE SIMULATION MAKES USE OF THE MONTE CARLO TECHNIQUE KNOWN AS ANTITHETIC VARIATES; THIS TECHNIQUE IS INTRODUCED IN ORDER TO IMPROVE SIMULATION EFFICIENCY. (SEE ALSO W73-12269) (BELL-CORNELL) JF - IN: PROCEEDINGS (VOL. *), INTERNATIONAL SYMPOSIUM ON UNCERTAINTIES IN HYDROLOGIC AND WATER RESOURCE SYSTEMS, UNIVERSITY OF ARIZONA, TUCSON, DECEMBER 11-14, 1972, P 64-90, (1972). 18 TAB, 8 REF. AU - Gaver, D P AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/12// PY - 1972 DA - Dec 1972 KW - Water Resources Abstracts KW - *SIMULATION ANALYSIS KW - *STOCHASTIC PROCESSES KW - *MONTE CARLO METHOD KW - *ESTIMATING KW - *VARIABILITY KW - COMPUTERS KW - EQUATIONS KW - DISTRIBUTION KW - OPERATION RESEARCH KW - MATHEMATICAL MODELS KW - HYDROLOGY KW - *'JACKKNIFE' METHOD KW - ANTITHETIC VARIATES TECHNIQUE KW - SW 5080:Evaluation, processing and publication KW - SW 2010:Control of water on the surface UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19075330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=METHODS+FOR+ASSESSING+VARIABILITY%2C+WITH+EMPHASIS+ON+SIMULATION+DATA+INTERPRETATIONS&rft.au=Gaver%2C+D+P&rft.aulast=Gaver&rft.aufirst=D&rft.date=1972-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SOME TECHNICAL AND ECONOMIC CONCERNS RELATING TO SHIPBOARD POLLUTION ABATEMENT AN - 19062566; 7403743 AB - THREE SHIPBOARD POLLUTION ABATEMENT QUESTIONS ARE EXAMINED. FIRST, TREATMENT SYSTEMS ARE EVALUATED WITH RESPECT TO COST, SAFETY, RELIABILITY AND SIZE, SUBJECT TO MINIMUM EPA STANDARDS. LIMITED FLUSH, INCINERATION AND BIOLOGICAL TREATMENT ARE FEASIBLE, WITH WET AIR OXIDATION CONSIDERED A RESEARCHABLE METHOD TO OBTAIN A FUTURE INTEGRATED WASTE DISPOSAL SYSTEM. LIMITED SPACE AND ADVERSE SALTWATER EFFECTS ON MICROORGANISMS MAKE BIOLOGICAL TREATMENT LESS DESIRABLE. THE BIOLOGICAL EFFECTS OF NAVAL OIL AND WASTE DUMPING IS ALSO EXAMINED. OCEAN SEWAGE DUMPING IS NOT AN EFFECTIVE BACTERICIDE, ALTHOUGH DIFFUSION, SUNLIGHT, OSMOTIC SHOCK AND PREDATION ARE BENEFICIAL; DUMPING DOES NOT PRESENTLY SERIOUSLY AFFECT THE OCEAN'S HOMEOSTASIS. SMALL OIL CONCENTRATIONS HAVE A MEASURABLE EFFECT ON THE DIVERSITY OF SURFACE DWELLING SPECIES. OIL-CONSUMING BACTERIA FARE POORLY IN THE OPEN SEA. TECHNOLOGICAL PROBLEMS ARE BRIEFLY DISCUSSED AND A SHORT LITERATURE REVIEW IS GIVEN. THE ECONOMIC SAVINGS OF SENDING WASTE ASHORE FOR TREATMENT IS THE THIRD QUESTION EXAMINED. ATTENTION IS GIVEN TO POSSIBLE ADVERSE AFFECTS OF SEAWATER ON MUNICIPAL SEWERAGE SYSTEMS AND INHIBITION OF BIOLOGICAL ACTIVITY. PUBLIC REACTION TO THIS METHOD APPEARS COOL, ALTHOUGH THERE ARE NO TECHNICAL OR ECONOMIC REASONS TO PRECLUDE ITS FEASIBILITY. (SCHROEDER-WISCONSIN) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-755 540, $3.00 IN PAPER COPY, $1.45 IN MICROFICHE. TECHNICAL REPORT NPS-61RW72121A, DECEMBER 1972. 57 P, 107 REF. AU - Rowell, C F AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/12// PY - 1972 DA - Dec 1972 KW - Water Resources Abstracts KW - *POLLUTION ABATEMENT KW - *SHIPS KW - *WASTE WATER TREATMENT KW - WATER POLLUTION SOURCE KW - SANITARY ENGINEERING KW - ESTIMATED COSTS KW - WASTE DISPOSAL KW - SW 3040:Wastewater treatment processes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19062566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SOME+TECHNICAL+AND+ECONOMIC+CONCERNS+RELATING+TO+SHIPBOARD+POLLUTION+ABATEMENT&rft.au=Rowell%2C+C+F&rft.aulast=Rowell&rft.aufirst=C&rft.date=1972-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A STUDY OF NUTRIENT VARIATIONS IN THE SURFACE AND MIXED LAYER OF MONTEREY BAY USING AUTOMATIC ANALYSIS TECHNIQUES AN - 19072962; 7314090 AB - CONCENTRATIONS OF SILICATE, PHOSPHATE, NITRATE, AND NITRITE WERE DETERMINED IN MONTEREY BAY, CALIFORNIA. DATA WERE COLLECTED ABOARD SHIP DURING FOUR CRUISES IN APRIL AND MAY, 1972 USING THE TECHNICON (TRADEMARK) AUTOANALYZER (TRADEMARK) II SYSTEM IN DUAL CHANNEL OPERATION. THE SENSITIVITY, REPRODUCIBILITY, AND ACCURACY OF THIS SYSTEM WERE INVESTIGATED AND THE RESULTS PRESENTED. NUTRIENT CONCENTRATIONS WERE PRESENTED AS SURFACE VARIATIONS, DEPTH VARIATIONS, AND VERTICAL PROFILES. THE LARGE VARIABILITY OF NUTRIENT CONCENTRATIONS IN THE OCEAN AREA STUDIED WAS DISCUSSED. UPWELLING AREAS WERE INVESTIGATED FOR NUTRIENT CONCENTRATIONS, CIRCULATION PATTERNS, AND VARIATIONS IN NUTRIENT RATIOS. PLANKTONIC BLOOM AREAS HAVE BEEN IDENTIFIED FROM THE LOW NUTRIENT LEVELS, LOW NUTRIENT RATIO VALUES, AND HIGH CHLOROPHYLL CORRELATIONS. RESULTS INDICATE THAT SILICATE WAS THE LIMITING NUTRIENT TO BIOLOGICAL ACTIVITY IN THE WATERS STUDIED. ASSIMILATION RATIOS FOR BIOLOGICAL ACTIVITY WERE FOUND TO BE 16.33 FOR NO3:PO4 AND 1.14 FOR SIO4:PO4. NUTRIENT PLATEAU REGIONS WERE ANALYZED AND SOURCES DISCUSSED. THE MAJOR CAUSE OF NUTRIENT CONCENTRATION CHANGES IN THE AREA (EXCEPT PLANKTON BLOOMS) AS DETERMINED FROM NUTRIENT RATIO STUDIES WAS FOUND TO BE CIRCULATION OF THE WATER MASSES. (HOLOMAN-BATTELLE) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-757 700. MASTER'S THESIS, SEPTEMBER 1972. 151 P, 57 FIG, 9 TAB, 21 REF. AU - Paulson, Go AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/09// PY - 1972 DA - Sep 1972 KW - Water Resources Abstracts KW - *AUTOMATION KW - *SEA WATER KW - *MIXOLIMNION KW - *NUTRIENTS KW - *CALIFORNIA KW - SURFACE WATERS KW - VARIABILITY KW - ESSENTIAL NUTRIENTS KW - WATER CIRCULATION KW - CHEMICAL ANALYSIS KW - WATER ANALYSIS KW - METHODOLOGY KW - MIXING KW - SILICATES KW - PHOSPHATES KW - NITRATES KW - NITRITES KW - DEPTH KW - EUTROPHICATION KW - UPWELLING KW - LIMITING FACTORS KW - CHLOROPHYLL KW - NITROGEN COMPOUNDS KW - ECOLOGICAL DISTRIBUTION KW - PLANKTON KW - WATER SAMPLING KW - SALINITY KW - PROFILES KW - COLORIMETRY KW - INSTRUMENTATION KW - RESEARCH EQUIPMENT KW - IRON KW - COLOR KW - TURBIDITY KW - SULFIDES KW - OCEANOGRAPHY KW - POLLUTANT IDENTIFICATION KW - *MONTEREY BAY KW - TECHNICON AUTOANALYZER II SYSTEM KW - SHIPBOARD MEASUREMENTS KW - ON BOARD ANALYSIS KW - REPRODUCIBILITY KW - SENSITIVITY KW - ACCURACY KW - ERROR SOURCES KW - DATA INTERPRETATION KW - ORTHOPHOSPHATES KW - CHEMICAL INTERFERENCE KW - TANNINS KW - PRECISION KW - ASSIMILATION KW - SW 3010:Identification of pollutants KW - SW 3020:Sources and fate of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19072962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+STUDY+OF+NUTRIENT+VARIATIONS+IN+THE+SURFACE+AND+MIXED+LAYER+OF+MONTEREY+BAY+USING+AUTOMATIC+ANALYSIS+TECHNIQUES&rft.au=Paulson%2C+Go&rft.aulast=Paulson&rft.aufirst=Go&rft.date=1972-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A MODEL FOR ALLOCATION OF SEWAGE TREATMENT SYSTEMS TO THE NAVAL FLEET AN - 19074056; 7307458 AB - THE PROBLEM OF PLANNING THE ALLOCATION OF SEWAGE TREATMENT SYSTEMS TO THE NAVAL FLEET IS DISCUSSED. IT IS ASSUMED THAT THE OBSOLESCENCE OR DETERIORATION PROCESS OF A SHIP IS A SEMI-MARKOV PROCESS. THE TOTAL DISCOUNTED COST OF REVAMPING A GROUP OF SHIPS IS DETERMINED AS A FUNCTION OF THE TIME HORIZON CHOSEN TO DO SO FOR THE SPECIAL CASE OF DETERMINISTIC DETERIORATION. THIS FUNCTION IS GRAPHED FOR A SET OF REPRESENTATIVE COST FACTORS. A VIEW TOWARDS A FUTURE SIMULATION STUDY IS PROVIDED BY A DISCUSSION OF THE SEMI-MARKOV AND MARKOV MODELS. (SMITH-TEXAS) JF - AVIALABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-747066, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. JULY 1972. 19 P, 1 FIG, 1 TAB, 2 REF. AU - Brill, E A AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/07// PY - 1972 DA - Jul 1972 KW - Water Resources Abstracts KW - *MARKOV PROCESSES KW - *SEWAGE TREATMENT KW - *WASTE WATER TREATMENT KW - *TREATMENT FACILITIES KW - *PROJECT PLANNING KW - PROJECT BENEFITS KW - PROJECT LIFE KW - SEWAGE KW - MODEL STUDIES KW - COST ANALYSIS KW - COST COMPARISONS KW - ECONOMICS KW - *NAVAL SEWAGE SYSTEMS KW - SW 3040:Wastewater treatment processes KW - SW 4020:Evaluation process UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19074056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+MODEL+FOR+ALLOCATION+OF+SEWAGE+TREATMENT+SYSTEMS+TO+THE+NAVAL+FLEET&rft.au=Brill%2C+E+A&rft.aulast=Brill&rft.aufirst=E&rft.date=1972-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SEASONAL VARIATIONS OF COASTAL CURRENTS OFF THE OREGON - NORTHERN CALIFORNIA COAST AN - 19085090; 7400037 AB - SEASONAL LONGSHORE FLOW PATTERNS ARE EXAMINED AT FOUR POINTS ALONG THE OREGON-NORTHERN CALIFORNIA COAST. SUMMER AND WINTER ACTIVITY IS EXAMINED AS FAR SEAWARD AS 25 NAUTICAL MILES AND AS DEEP AS 200 METERS. LONG-TERM MEAN HYDROGRAPHIC DATA ARE USED TO DETERMINE GEOSTROPHIC VELOCITIES. A NEARSHORE BAROCLINIC SOUTHWARD FLOW IS OBSERVED AT EACH OF THE POINTS DURING THE SUMMER. WINTER CURRENTS ARE GENERALLY VERY SMALL AND LARGELY BAROTROPHIC IN NATURE. SEASONAL VOLUME TRANSPORTS ARE PRESENTED; CORRECTED VELOCITY PROFILES ARE ALSO PRESENTED BASED ON DATA FROM MOORED CURRENT METERS. QUALITIATIVE EXPLANTIONS OF THE OBSERVED PHENOMENA ARE CONSIDERED. (SINHA-OEIS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-749 077, $3.00 IN PAPER COPY, $1.45 IN MICROFICHE. MASTER'S THESIS, JUNE 1972. 52 P, 13 FIG, 4 TAB, 17 REF. AU - Whitson, W F AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/06// PY - 1972 DA - Jun 1972 KW - Water Resources Abstracts KW - *COASTS KW - *CURRENTS(WATER) KW - *UPWELLING KW - *WINDS KW - *CLIMATE KW - SUBSURFACE FLOW KW - OCEAN CIRCULATION KW - SHALLOW WATER KW - OREGON KW - CALIFORNIA KW - PACIFIC COAST REGION KW - SURFACE JET KW - *NEAR SHORE PROCESSES KW - *COASTAL PROCESSES KW - PYCNOCLINE KW - COLUMBIA RIVER DISCHARGE KW - PRESSURE GRADIENT KW - VOLUME TRANSPORT KW - GEOSTROPHIC VELOCITIES KW - BAROCLINIC FLOW KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19085090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SEASONAL+VARIATIONS+OF+COASTAL+CURRENTS+OFF+THE+OREGON+-+NORTHERN+CALIFORNIA+COAST&rft.au=Whitson%2C+W+F&rft.aulast=Whitson&rft.aufirst=W&rft.date=1972-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - DEVELOPMENT OF AN OIL/WATER POLLUTION MONITOR AN - 19065933; 7310491 AB - BECAUSE OF THE SIMPLICITY, RUGGEDNESS, AND STATE OF THE ART, ULTRASONIC TECHNIQUES WERE CHOSEN FOR MONITORING OIL IN BILGE AND BALLAST WATER FROM SHIPS. CRYSTALLINE QUARTZ WAS USED TO PRODUCE ULTRASONIC WAVES AT 30 MHZ WHICH WERE MONITORED FOR ATTENUATION USING ANOTHER QUARTZ CRYSTAL. THE SYSTEM WAS TESTED IN THE LABORATORY WITH A TANK DESIGNED TO CIRCULATE CONTAMINATED WATER PAST THE MONITOR. CALIBRATIONS WERE MADE WITH DISTILLED WATER BEFORE TESTING WITH WATER CONTAINING UP TO 500 PPM FUEL OIL. RESULTS WITH CONTAMINATED TAP WATER WERE INCONCLUSIVE, BUT ATTENUATION WAS FOUND TO VARY LINEARLY WITH OIL CONCENTRATION WHEN THE CONTAMINANT LEVEL WAS LESS THAN 500 PPM IN DISTILLED WATER. TURBULENCE DISTURBED THE SIGNALS, BUT COULD PROBABLY BE ELIMINATED BY FILTERING. ALTHOUGH RESULTS ARE PRELIMINARY, THE METHOD IS POTENTIALLY USEFUL FOR MONITORING RELATIVELY LOW LEVELS OF OIL IN WATER. (LITTLE-BATTELLE) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-747 084, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MASTER'S THESIS, JUNE 1972. 35 P, 11 FIG, 10 REF. AU - McGrath, F K AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/06// PY - 1972 DA - Jun 1972 KW - Water Resources Abstracts KW - *OILY WATER KW - *MONITORING KW - *ELECTRONIC EQUIPMENT KW - *ULTRASONICS KW - WATER ANALYSIS KW - *FUEL OIL KW - BILGE WATER KW - BALLAST WATER KW - SW 5040:Data acquisition KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19065933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=DEVELOPMENT+OF+AN+OIL%2FWATER+POLLUTION+MONITOR&rft.au=McGrath%2C+F+K&rft.aulast=McGrath&rft.aufirst=F&rft.date=1972-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - DESCRIPTIVE MODEL OF A SHIPBOARD ECOLOGICAL SYSTEM AN - 19056658; 7305017 AB - TWO COMPUTER SIMULATIONS EMPLOYING MONTE CARLO ANALYSIS WERE DEVELOPED TO DESCRIBE THE GENERATION OF SEWAGE AND TO HELP SOLVE THE PROBLEM OF ECONOMICALLY PROCESSING SEWAGE ON BOARD NAVAL SHIPS. A NON-HOMOGENEOUS POISSON PROCESS WAS THE BASIS OF SIMULATION ONE AND AN EMPIRICAL DISTRIBUTION DESCRIBING THE ARRIVAL BEHAVIOR OF SEWAGE TO THE HOLDING PROCESSING UNIT OVER A 24 HOUR PERIOD WAS APPLIED TO KNOWN DATA ON SEWAGE GENERATION IN SIMULATION TWO. RESULTS OF THE TWO SIMULATIONS WERE COMPATIBLE WITH ONE ANOTHER. THE SIMULATIONS INDICATED THAT A REVISION OF THE NAVY'S DESIGN PARAMETER FOR THE DAILY PER CAPITA SEWAGE GENERATION RATE WAS IN ORDER, AND ALSO POINTED OUT A FEASIBLE COMBINATION OF HOLDING TANK CAPACITY, PROCESSOR RATE AND PROCESSING POLICY. THE SIMULATIONS WERE DESIGNED SO THAT USE BY OTHERS WITH THEIR OWN DATA WOULD BE EASY. (SMITH-TEXAS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-743 764, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MASTER'S THESIS, JUNE 1972. 64 P, 6 FIG, 20 REF. AU - Miner, Jo AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/06// PY - 1972 DA - Jun 1972 KW - Water Resources Abstracts KW - *SHIPS KW - *SEWAGE TREATMENT KW - *WASTE DISPOSAL KW - *WASTE WATER TREATMENT KW - *SIMULATION ANALYSIS KW - SEWAGE EFFLUENTS KW - WASTE STORAGE KW - STOCHASTIC PROCESSES KW - COMPUTER MODELS KW - SANITARY ENGINEERING KW - MODEL STUDIES KW - *SHIPBOARD SEWAGE PROCESSING KW - SW 3040:Wastewater treatment processes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19056658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=DESCRIPTIVE+MODEL+OF+A+SHIPBOARD+ECOLOGICAL+SYSTEM&rft.au=Miner%2C+Jo&rft.aulast=Miner&rft.aufirst=Jo&rft.date=1972-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THE USE OF OCEAN TIDE RECORDS TO DETECT MOTIONS PREMONITORY TO A TECTONIC EVENT IN THE LONG BEACH, CALIFORNIA AREA AN - 19083567; 7311214 AB - THE GOAL WAS TO EXTRACT THE MOST POWERFUL HARMONIC PORTIONS OF THE OCEAN TIDES AND THE METEOROLOGICAL EFFECTS FROM SERIES OF OCEAN TIDE LEVEL OBSERVATIONS FROM SEVERAL STATIONS TO GENERATE RESIDUAL TIME SERIES REFLECTING GEOLOGICAL AND TECTONIC MOTIONS AT THE STATIONS. MARIGRAM RECORDS OF OCEAN TIDE FLUCTUATIONS AT THREE TIDE STATIONS OPERATING IN THE SANTA MONICA/LONG BEACH, CALIFORNIA, AREA AT THE TIME OF THE MARCH 10, 1933, LONG BEACH EARTHQUAKE (MAGNITUDE 6.3) WERE DIGITIZED ONTO MAGNETIC TAPE. TIME SERIES OF HOURLY INSTANTANEOUS TIDE LEVEL OBSERVATIONS WERE GENERATED AND PROCESSED UNDER A LEAST SQUARES CRITERION TO REMOVE THE EFFECTS OF THE NINE MOST ENERGETIC LINES OF THE OCEAN TIDE HARMONIC SPECTRUM. THE RESULTING RESIDUAL SERIES DID NOT CONTAIN ANY ANOMALOUS PREMONITORY MOTIONS INDICATED BY ANOTHER RESIDUAL SERIES PREVIOUSLY ANALYZED AT THE NATIONAL CENTER FOR EARTHQUAKE RESEARCH. AUTO- AND CROSS-CORRELATIONS OF THE THREE RESIDUAL SERIES USED REVEALED ONLY TWO POSSIBLY SIGNIFICANT AUTO-CORRELATION PEAKS FOR TWO STATIONS LAGGING THEMSELVES BY 24 HOURS. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA. 22151, AD-753 596, PRICE $3.00 PRINTED COPY; $0.95 MICROFICHE. M SC THESIS, SEPTEMBER 1972. 74 P, 17 FIG, 9 TAB, 44 REF. AU - Wyman, B D AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/04// PY - 1972 DA - Apr 1972 KW - Water Resources Abstracts KW - *TSUNAMIS KW - *OCEAN WAVES KW - *WAVES(WATER) KW - *EARTHQUAKES KW - *CALIFORNIA KW - TIDES KW - DATA COLLECTIONS KW - COMPUTER PROGRAMS KW - METHODOLOGY KW - WATER LEVELS KW - CORRELATION ANALYSIS KW - METEOROLOGY KW - OCEAN CURRENTS KW - RESIDUAL TIME SERIES KW - GEOLOGICAL MOTIONS KW - TECTONIC MOTIONS KW - SW 5040:Data acquisition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19083567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THE+USE+OF+OCEAN+TIDE+RECORDS+TO+DETECT+MOTIONS+PREMONITORY+TO+A+TECTONIC+EVENT+IN+THE+LONG+BEACH%2C+CALIFORNIA+AREA&rft.au=Wyman%2C+B+D&rft.aulast=Wyman&rft.aufirst=B&rft.date=1972-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - MEASUREMENT OF THE COMPLEX DYNAMIC RIGIDITY OF RECENT MARINE SEDIMENTS AN - 19081878; 7402146 AB - THE DYNAMIC RIGIDITY OF 17 SAMPLES OF CONTINENTAL TERRACE CLAYEYSILT SEDIMENTS WAS MEASURED IN THE LABORATORY USING VISCOELASTOMETER IN THE FREQUENCY RANGE OF 7 TO 60 KHZ. THE METHOD INVOLVED THE PROGAGATION OF TORSIONAL WAVES ON A ROD AND MEASURING THE EFFECTS OF SHEAR LOADING IMPARTED TO THE ROD WHEN IMBEDDED IN A SEDIMENT. VALUES OF THE REAL COMPONENT OF RIGIDITY RANGED FROM 1,600,000 DYNES/SQ CM TO 21,000,000 DYNES/SQ CM. VALUES OF THE IMAGINARY COMPONENT OF RIGIDITY RANGED FROM 200,000 DYNES/SQ COM TO 41,000,000 DYNES/SQ COM. NO CLEAR-CUT DEPENDENCE OF RIGIDITY UPON FREQUENCY WAS OBSERVED. BOTH REAL AND IMAGINARY COMPONENTS OF RIGIDITY WERE ANALYZED BY PLOTTING THE DATA AS A FUNCTION OF VARIOUS OTHER MASS-PHYSICAL PROPERTIES INCLUDING: DENSITY, POROSITY, COMPRESIONAL WAVE SPEED, SAND-SILT-CLAY PERCENTAGES, VANE SHEAR STRENGTH, AND THE PRODUCT OF DENSITY AND SOUND SPEED SQUARED. THESE ANALYSES SUBSTANTIATE RESEARCH DONE BY OTHER WORKERS INDICATING THAT BOTH REAL AND IMAGINARY COMPONENTS OF RIGIDITY EXHIBIT TRENDS WITH SOME OF THE MASS-PHYSICAL PROPERTIES. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA 22151 AD-758 678 PRICE $3.00 PRINTED COPY; $1.45. M SC THESIS, DECEMBER 1972. 78 P, 32 FIG, 9 TAB, 18 REF. AU - Engel, G A AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/04// PY - 1972 DA - Apr 1972 KW - Water Resources Abstracts KW - *SEDIMENTOLOGY KW - *SEDIMENTS KW - *CONTINENTAL SHELF KW - *MARINE GEOLOGY KW - SAMPLING KW - RIGIDITY KW - TESTING PROCEDURES KW - PHYSICAL PROPERTIES KW - DENSITY KW - POROSITY KW - PARTICLE SIZE KW - SHEAR STRENGTH KW - COMPUTER PROGRAMS KW - CORRELATION ANALYSIS KW - VISCOMETERS KW - VISCOSITY KW - SW 0870:Erosion and sedimentation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19081878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=MEASUREMENT+OF+THE+COMPLEX+DYNAMIC+RIGIDITY+OF+RECENT+MARINE+SEDIMENTS&rft.au=Engel%2C+G+A&rft.aulast=Engel&rft.aufirst=G&rft.date=1972-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - WAVE-INDUCED WATER PARTICLE MOTION MEASUREMENTS AN - 19079614; 7401285 AB - DURING JUNE 8, 1972 RECORDS OF ORTHOGONAL WATER PARTICLE VELOCITY AND INSTANTANEOUS WATER ELEVATION WERE MEASURED AT THE NAVAL UNDERSEA RESEARCH AND DEVELOPMENT CENTER (NUC) TOWER LOCATED APPROXIMATELY 1 MILE OFF MISSION BEACH, CALIFORNIA. SIMULTANEOUS MEASUREMENTS OF WAVE HEIGHT AND TWO ORTHOGONAL WATER PARTICLE VELOCITIES WERE MADE AT SIX ELEVATIONS IN 19 METERS OF WATER USING A PENETRATING WAVE STAFF AND AN ELECTROMAGNETIC FLOWMETER. MODERATE SWELL AND LOW WIND CONDITIONS PREVAILED DURING THE EXPERIMENT. THE MEASURED WAVE-INDUCED VELOCITIES WERE 2%-4% GREATER THAN THOSE PREDICTED USING LINEAR WAVE THEORY. COHERENCE OF THE WAVE HEIGHT AND WAVE-INDUCED VELOCITIES IN THE SIGNIFICANT ENERGY-DENSITY RANGE WAS COMPUTED TO BE OVER 0.85, INDICATING THAT THE MOTION WAS ALMOST TOTALLY WAVE INDUCED. AT HIGHER FREQUENCIES IT WAS APPARENT THAT THE MOTION WAS PRIMARILY TURBULENCE. PHASE SPECTRA COMPUTED FOR THE MEASURED WAVE HEIGHTS AND ORBITAL VELOCITIES COMPARED VERY WELL WITH LINEAR THEORY. MEASURED FREQUENCY DISTRIBUTIONS WERE COMPARED TO BOTH GAUSSIAN AND GRAM-CHARLIER DISTRIBUTIONS USING THE CHI-SQUARED GOODNESS-OF-FIT TEST. QUALITATIVELY, THE GRAM-CHARLIER DISTRIBUTION GAVE THE BETTER FIT TO THE DATA. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA., 22151, AD-756 577 PRICE $3.00 PRINTED COPY; $1.45 MICROFICHE. M SC THESIS, DECEMBER 1972. 61 P, 6 FIG, 4 TAB, 19 REF. AU - Krapohl, R F AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/04// PY - 1972 DA - Apr 1972 KW - Water Resources Abstracts KW - *WAVES(WATER) KW - *OCEAN WAVES KW - *MODEL STUDIES KW - *MOVEMENT KW - FLOW RATES KW - DEPTH KW - VELOCITY KW - FLOW MEASUREMENT KW - CURRENT METERS KW - WINDS KW - EQUATIONS KW - *WATER PARTICLE MOTION KW - WAVE-INDUCED WATER KW - WAVE SPECTRA KW - SW 5040:Data acquisition KW - SW 0835:Streamflow and runoff KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19079614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=WAVE-INDUCED+WATER+PARTICLE+MOTION+MEASUREMENTS&rft.au=Krapohl%2C+R+F&rft.aulast=Krapohl&rft.aufirst=R&rft.date=1972-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - ONSHORE-OFFSHORE SAND TRANSPORT ON DEL MONTE BEACH, CALIFORNIA AN - 19077288; 7311086 AB - DAILY SAND VOLUME TRANSPORT VALUES WERE CALCULATED AT A BEACH PROFILE DURING A 2-MONTH PERIOD. WAVE DATA WERE RECORDED CONTINUOUSLY DIRECTLY SEAWARD OF THE PROFILE. TIDE EFFECTS WERE LARGELY FILTERED OUT BY USE OF A LUNAR DAY (24.8 HOURS) SAMPLING INTERVAL. OFFSHORE SAND TRANSPORT OCCURRED IN ISOLATED EVENTS OF 1- TO 2-DAY DURATION, AND HAD A MAXIMUM VALUE OF 132.5 CUBIC FEET PER FOOT OF BEACH WIDTH PER LUNAR DAY. ONSHORE TRANSPORT OCCURRED OVER LONGER INTERVALS OF UP TO 7 DAYS, AND HAD A MAXIMUM VALUE OF 47.0 CUBIC FEET PER FOOT PER DAY. ONSHORE-OFFSHORE TRANSPORT OVER A 24.8-HOUR PERIOD DEPENDS, TO A FIRST APPROXIMATION, ON THE MEAN WAVE STEEPNESS INCIDENT UPON THE BEACH AND THE INITIAL BEACH SLOPE FOR THE PERIOD. IF THE INITIAL BEACH SLOPE IS GREATER THAN THE EQUILIBRIUM SLOPE ASSOCIATED WITH THE EXISTING WAVE CONDITIONS, OR IF THE PROFILE IS INITIALLY AT EQUILIBRIUM AND THE WAVE STEEPNESS INCREASES, SAND WILL BE MOVED OFFSHORE. THE CLOSER TO EQUILIBRIUM THE BEACH IS, THE SMALLER THE TRANSPORTS. (KNAPP-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA 22151 AD-751 595, PRICE $3.00 PRINTED COPY; $0.95 MICROFICHE. M SC THESIS, SEPTEMBER 1972. 62 P, 10 FIG, 1 TAB, 22 REF, 3 APPEND. AU - Williamson, J D AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF. DEPT. OF OCEANOGRAPHY Y1 - 1972/04// PY - 1972 DA - Apr 1972 KW - Water Resources Abstracts KW - *BEACH EROSION KW - *SEDIMENT TRANSPORT KW - *CALIFORNIA KW - DATA COLLECTIONS KW - SEDIMENTATION KW - PROFILES KW - WAVES(WATER) KW - SLOPES KW - SURF KW - SAMPLING KW - SANDS KW - LITTORAL DRIFT KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19077288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=ONSHORE-OFFSHORE+SAND+TRANSPORT+ON+DEL+MONTE+BEACH%2C+CALIFORNIA&rft.au=Williamson%2C+J+D&rft.aulast=Williamson&rft.aufirst=J&rft.date=1972-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SAND MOVEMENT ALONG CARMEL RIVER STATE BEACH, CARMEL, CALIFORNIA AN - 19073416; 7311557 AB - THE DIRECTION OF SAND MOVEMENT ALONG THE CARMEL RIVER STATE BEACH IN CALIFORNIA WAS QUALITATIVELY DETERMINED BY DIVING OBSERVATIONS, A BATHYMETRIC SURVEY, WAVE REFRACTION DIAGRAMS AND A SEDIMENT SIZE ANALYSIS OF 18 SAMPLES. THE PRIMARY SOURCE OF SEDIMENTS FOR THE BEACH APPEARS TO BE THE CARMEL RIVER WHICH FLOWS ONLY SEASONALLY. SEDIMENTARY MATERIAL IS INTRODUCED INTO THE BAY AFTER WINTER PRECIPITATION PROVIDES A SUFFICIENT AMOUNT OF RUNOFF TO WARRENT THE OPENING OF THE RIVER MOUTH BY BULLDOZER. THE FINE SEDIMENTARY MATERIAL IS LOST OFFSHORE AND THE COARSER MATERIAL IS EITHER REDEPOSITED ON THE BEACH OR IS CARRIED SOUTH WITH THE LITTORAL DRIFT AND DEPOSITED AT A NODAL POINT IN THE SAND TRANSPORT PATTERN. THIS NODE IS LOCATED ON THE NORTHERN EDGE OF THE HEAD OF THE CARMEL SUBMARINE CANYON. WINTER STORMS PROBABLY INDUCE SLUMPING OR GRAVITY SLIDING AND MUCH OF THE MATERIAL IS CARRIED TO DEEPER WATER BY THE CANYON. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA. 22151 AS AD-753 623, PRICE $3.00 PRINTED COPY; $0.95 MICROFICHE. M SC THESIS, SEPTEMBER 1972. 67 P, 17 FIG, 1 TAB, 25 REF, 2 APPEND. AU - Howell, B F AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/04// PY - 1972 DA - Apr 1972 KW - Water Resources Abstracts KW - *SEDIMENT TRANSPORT KW - *BEACH EROSION KW - *LITTORAL DRIFT KW - *BAYS KW - *CALIFORNIA KW - SEDIMENTS KW - SANDS KW - PARTICLE SIZE KW - ANALYTICAL TECHNIQUES KW - ESTUARIES KW - SEDIMENTOLOGY KW - COASTS KW - OCEAN WAVES KW - TIDAL EFFECTS KW - RIVER FLOW KW - INFLOW KW - *CARMEL RIVER STATE BEACH(CALIF) KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19073416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SAND+MOVEMENT+ALONG+CARMEL+RIVER+STATE+BEACH%2C+CARMEL%2C+CALIFORNIA&rft.au=Howell%2C+B+F&rft.aulast=Howell&rft.aufirst=B&rft.date=1972-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - KINEMATICS OF WATER PARTICLE MOTION WITHIN THE SURF ZONE AN - 19061997; 7314105 AB - THE KINEMATICS OF THE WATER PARTICLE MOTION WITHIN THE SURF ZONE AND WITHIN BREAKING WAVES WAS STUDIED. SIMULTANEOUS MEASUREMENTS OF SEA SURFACE ELEVATION AND HORIZONTAL AND VERTICAL PARTICLE VELOCITIES AT 39 AND 69 CM ELEVATIONS IN THE COLUMN OF WATER OF 130 CM TOTAL DEPTH WERE MADE INSIDE THE SURF ZONE. ALSO, THE OFFSHORE SEA SURFACE ELEVATION AT THIS LOCATION WAS MEASURED FOR PURPOSES OF COMPARISON. THE VELOCITIES WERE MEASURED USING ELECTROMAGNETIC FLOW METERS, AND THE SEA SURFACE ELEVATION WAS MEASURED USING PRESSURE WAVE GAGES. PROBABILITY DENSITY FUNCTIONS, PDF, WERE DETERMINED FOR EACH RECORD. THE PDF'S FOR THE SEA SURFACE ELEVATION AND PARTICLE VELOCITIES INSIDE THE SURF ZONE WERE HIGHLY SKEWED. SPECTRAL COMPUTATIONS SHOW THAT THE RANGE OF SIGNIFICANT ENERGY WAS BETWEEN 0.05 AND 0.6 HERTZ. THE PHASE ANGLE WAS COMPARED TO LINEAR WAVE THEORY AND SHOWS A SHIFTING OF PHASE FOR THE HORIZONTAL VELOCITY WITH SEA SURFACE ELEVATION FROM 0 DEG AT LOW FREQUENCY TO 90 DEG AT HIGHER FREQUENCIES. THE ENERGY-DENSITY SPECTRA SHOW THAT THE HORIZONTAL COMPONENT IS APPROXIMATELY 95% OF THE TOTAL KINETIC ENERGY OF THE SURF ZONE. IN THE RANGE OF SIGNIFICANT ENERGY, A COHERENCE OF ABOUT 0.9 WAS FOUND FOR THE SEA SURFACE ELEVATION AND PARTICLE VELOCITIES WHICH INDICATES THAT THE PARTICLE MOTION INSIDE THE SURF ZONE IS FOR THE MOST PART WAVE-INDUCED. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA. 22151 AS AD-756 523; PRICE $3.00 PRINTED COPY; $1.45 MICROFICHE. M SC THESIS, SEPTEMBER 1972. 56 P, 25 FIG, 7 REF. AU - Steer, R AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/04// PY - 1972 DA - Apr 1972 KW - Water Resources Abstracts KW - *KINETICS KW - *OCEAN WAVES KW - *SURF KW - *OCEAN CURRENTS KW - MEASUREMENT KW - CURRENT METERS KW - METHODOLOGY KW - VELOCITY KW - DENSITY KW - ENERGY KW - TIDES KW - BREAKING WAVES KW - WATER PARTICLE MOTION KW - SW 0835:Streamflow and runoff UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19061997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=KINEMATICS+OF+WATER+PARTICLE+MOTION+WITHIN+THE+SURF+ZONE&rft.au=Steer%2C+R&rft.aulast=Steer&rft.aufirst=R&rft.date=1972-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - CHARACTERIZATION OF GELBSTOFFE IN MONTEREY BAY BY NYLON ADSORPTION, UV, AND PAPER CHROMATOGRAPHY AN - 19058123; 7306388 AB - DISSOLVED ORGANIC COMPONENTS OF MARINE WATERS WERE STUDIED USING AN INVERSE-FLOW GLASS FILTER SYSTEM TO SEPARATE THE PARTICULATE AND DISSOLVED CONSTITUENTS. CELL RUPTURE WAS PREVENTED BY THE USE OF A GENTLE POSITIVE HYDRAULIC HEAD. CONCENTRATIONS OF HUMIC ACIDS WERE OBTAINED BY A NYLON ADSORPTION COLUMN WHICH ALSO DESALTED THE SAMPLE. THE PROCESS PROVIDED CONCENTRATIONS UP TO 10,000 TIMES. PAPER CHROMATOGRAPHY AND ULTRA-VIOLET SPECTROMETRY WERE USED TO CHARACTERIZE THE DISSOLVED HUMIC CONTENT OF WATER FROM MONTEREY BAY, CALIFORNIA, AND OFFSHORE OCEAN STATIONS. THE CORRELATIONS BETWEEN SOURCES INDICATED THE RELATIVE IMPORTANCE OF ORGANIC ACIDS, AMINO ACIDS, PHENOLS, AND CARBOHYDRATES IN SEWAGE OUTFALLS, KELPBEDS, HARBOR AREAS, RIVER MOUTHS, RIP CURRENTS AND INDUSTRIAL DISCHARGES. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA 22151 AD-745 172; PRICE $3.00 PRINTED COPY; 95 CENTS MICROFICHE. M SC THESIS, MARCH 1972. 95 P, 48 FIG, 5 TAB, 36 REF. AU - Lewis, L W AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/04// PY - 1972 DA - Apr 1972 KW - Water Resources Abstracts KW - *ORGANIC MATTER KW - *BAYS KW - *CALIFORNIA KW - WATER POLLUTION SOURCES KW - PACIFIC OCEAN KW - COASTS KW - CHEMICAL ANALYSIS KW - WASTES KW - SEWAGE KW - SEWAGE EFFLUENTS KW - CHROMATOGRAPHY KW - PHENOLS KW - HUMIC ACIDS KW - ORGANIC ACIDS KW - AMINO ACIDS KW - INDUSTRIAL WASTES KW - POLLUTANT IDENTIFICATION KW - *MONTEREY BAY(CALIF) KW - *DISSOLVED ORGANICS KW - *GELBSTOFFE KW - ULTRAVIOLET SPECTRA KW - SW 3010:Identification of pollutants KW - SW 3020:Sources and fate of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19058123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=CHARACTERIZATION+OF+GELBSTOFFE+IN+MONTEREY+BAY+BY+NYLON+ADSORPTION%2C+UV%2C+AND+PAPER+CHROMATOGRAPHY&rft.au=Lewis%2C+L+W&rft.aulast=Lewis&rft.aufirst=L&rft.date=1972-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SPECTRA OF TURBULENT FLUCTUATIONS OVER OCEAN WAVES AN - 19050436; 7311087 AB - SEVERAL APPLIED PROBLEMS, ESPECIALLY LONG RANGE ATMOSPHERIC PREDICTION, HAVE CREATED CONSIDERABLE INTEREST IN THE CONTRIBUTORY EFFECTS OF THE NEAR SURFACE BOUNDARY LAYER OVER THE OCEANS. SIGNIFICANT PROGRESS OCCURRED IN 1969 WITH RESPECT TO OBSERVATIONAL STUDIES AS A RESULT OF THE BARBADOS OCEANOGRAPHIC AND METEOROLOGICAL EXPERIMENT (BOMEX). BOMEX TOOK PLACE IN THE ATLANTIC OCEAN EAST-NORTHEAST OF BARBADOS, WEST INDIES. SPECTRAL ANALYSES WERE PERFORMED ON TURBULENCE DATA OBTAINED OVER OCEAN WAVES DURING BOMEX. RESULTS OF SEVEN SELECTED PERIODS WERE EXAMINED WITH RESPECT TO PREDICTIONS IN RECENT NONLINEAR AND LINEAR WIND-WAVE COUPLING THEORIES. PEAKS IN THE VELOCITY SPECTRA OCCURRED AT THE FREQUENCY OF THE WAVE SPECTRA PEAKS (0.1 HZ). AT A FREQUENCY (0.26 HZ) SLIGHTLY HIGHER THAN THAT OF THE WAVE SPECTRUM PEAK THE WIND-WAVE PHASE RELATIONSHIP CHANGES ABRUPTLY. THIS CHANGE OCCURRED AT A FREQUENCY WHERE THE WAVE PHASE SPEED WAS ROUGHLY TWO-THIRDS THE MEAN WIND SPEED AT THE LEVEL OF MEASUREMENT. AT THIS SAME FREQUENCY THE WIND-WAVE CORRELATION APPROACHED ZERO, AND INCREASED MOMENTUM TRANSFER WAS OBSERVED. AN EXAMINATION OF THE AMPLITUDE RATIO RESULTS CONFIRMED THE FREQUENCY OF MINIMUM WAVE INDUCED DISTURBANCE TO BE AT ABOUT 0.26 HZ. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA 22151 AS AD-753 624, PRICE $3.00 PRINTED COPY; $0.95 MICROFICHE. M SC THESIS, SEPTEMBER 1972. 62 P, 24 FIG, 22 REF. AU - Bingham, G S AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/04// PY - 1972 DA - Apr 1972 KW - Water Resources Abstracts KW - *WEATHER FORECASTING KW - *AIR-WATER INTERFACES KW - *OCEANS KW - *OCEAN WAVES KW - *WAVES(WATER) KW - TURBULENCE KW - WINDS KW - ANALYTICAL TECHNIQUES KW - SPECTROSCOPY KW - SPECTRAL ANALYSIS KW - WIND-WAVE COUPLING KW - BOMEX KW - SEA-AIR INTERACTION KW - SW 0880:Chemical processes KW - SW 5040:Data acquisition KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19050436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SPECTRA+OF+TURBULENT+FLUCTUATIONS+OVER+OCEAN+WAVES&rft.au=Bingham%2C+G+S&rft.aulast=Bingham&rft.aufirst=G&rft.date=1972-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - ANALYSIS OF THE EFFECTS ON OIL SPILLS OF FUEL POLICY CHANGES AND THE ADDITION OF ANOTHER FUEL PIER WITH THE AID OF A COMPUTER SIMULATION MODEL AN - 19273428; 7302908 AB - A LIMITED SIMULATION MODEL IS DEVELOPED FOR ANALYZING THE EFFECTS OF CHANGES IN REFUELING POLICIES AND IN FUEL PIER UTILIZATION ON OIL SPILLS. TWO CHANGES IN U.S. NAVY REFUELING POLICY ARE EXAMINED: (1) LOWERING THE MINIMUM FUEL PERCENTAGE REQUIRED ON BOARD, AND (2) ESTABLISHING A MAXIMUM ALLOWABLE LEVEL TO WHICH FUEL TANKS MAY BE FILLED. SIMULATIONS INDICATED THAT IT WOULD BE NECESSARY TO REDUCE THE ON-BOARD FUEL REQUIREMENTS TO A DRASTICALLY LOW LEVEL IN ORDER TO NOTICEABLY AFFECT THE OIL SPILL CLEAN-UP COSTS. FOR INSTANCE, IF THE REQUIREMENT WAS REDUCED TO 50 PERCENT, THE CLEAN-UP COSTS WOULD ONLY BE REDUCED BY $6,000 OR 11 PERCENT. SIMULATIONS ALSO INDICATED THAT RESTRICTING NAVY SHIPS FROM FILLING FUEL TANKS ABOVE A MAXIMUM LEVEL OF, SAY, 90 PERCENT WOULD SIGNIFICANTLY REDUCE THE NUMBER OF SPILLS CAUSED BY OVERFLOWS. IF SUCH A POLICY WERE ONLY 50 PERCENT EFFECTIVE, CLEAN-UP COSTS WOULD BE REDUCED BY APPROXIMATELY 45 PERCENT. THE STUDY SUGGESTS THAT BOTH REFUELING POLICIES SHOULD BE IMPLEMENTED CONCURRENTLY. FINALLY, THE STUDY SUGGESTED THAT A POLICY REQUIRING THE EXCLUSIVE USE OF FUEL PIERS FOR FUEL EXCHANGES COULD REDUCE THE NUMBER OF OIL SPILLS BY UP TO 48 PERCENT. (SEE ALSO W73-02901) (SETTLE-WISCONSIN) JF - IN: IMMEDIATE COST-EFFECTIVE ABATEMENT OF WATER POLLUTION FROM NAVY SHIPS, NAVAL POSTGRADUATE SCHOOL, P 257-292, MARCH, 1972. 7 FIG, 4 TAB, 9 REF. AU - Laabs, S K AU - Bowman, T L AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *FUELS KW - *PIERS KW - COSTS KW - BENEFITS KW - *REFUELING POLICIES KW - *FUEL PIER UTILIZATION KW - *FUEL PIERS KW - CLEANUP COSTS KW - COST SAVINGS KW - SIMULATION KW - SW 3070:Water quality control KW - SW 4020:Evaluation process UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19273428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=ANALYSIS+OF+THE+EFFECTS+ON+OIL+SPILLS+OF+FUEL+POLICY+CHANGES+AND+THE+ADDITION+OF+ANOTHER+FUEL+PIER+WITH+THE+AID+OF+A+COMPUTER+SIMULATION+MODEL&rft.au=Laabs%2C+S+K%3BBowman%2C+T+L&rft.aulast=Laabs&rft.aufirst=S&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - CHARACTERIZATION AND TREATMENT OF BILGE AND BALLAST WATER AN - 19272618; 7302905 AB - THE PROBLEM OF CONTROLLING OIL POLLUTION CREATED BY THE DISCHARGE OF BILGE WATER FROM U.S. NAVY SHIPS WAS INVESTIGATED. THE INVESTIGATION WAS BASED ON SAMPLES OF BILGE WATER OBTAINED FROM SHIPS IN THE SAN DIEGO AND LONG BEACH HARBORS. OIL IN BILGE WATER WAS FOUND TO RANGE IN CONCENTRATION FROM 100 PPM TO 100 PERCENT AND TO BE OF THE SAME TYPE AS FOUND IN THE PIPING SYSTEM OF THE SPACES ABOVE THE BILGES. SUCH OIL CONCENTRATIONS ARE ABOVE NAVY EFFLUENT STANDARDS; CONSEQUENTLY, THE PUMPING OF UNTREATED BILGE WATER FROM ANY SHIP LEVEL IS NOT AN ACCEPTABLE PROCEDURE. IT IS THUS NECESSARY TO TREAT THE BILGE WATER IN SOME MANNER IN ORDER TO REDUCE THE OIL CONCENTRATION PRIOR TO DISCHARGE. OF THE MANY OIL REMOVAL METHODS EXAMINED, ONLY THREE WERE APPLICABLE AS TEMPORARY SOLUTIONS FOR CONTROLLING BILGE WATER POLLUTION. THESE METHODS WERE BIOLOGICAL DEGRADATION, BILGE BALLAST TRANSFER, AND USAGE OF A HARBOR DONUT. MECHANICAL SEPARATION SYSTEMS SUCH AS CENTRIFUGES AND COALESCERS WERE DISCARDED AS SOLUTIONS BECAUSE OF THEIR COST, INSTALLATION TIME, AND FAILURE TO MEET EFFLUENT SPECIFICATIONS. BIOLOGICAL DEGRADATION APPEARED TO BE THE MOST ATTRACTIVE TEMPORARY SOLUTION BECAUSE OF LOW COST, RAPID IMPLEMENTATION, AND TOTAL OIL REMOVAL POTENTIAL. (SEE ALSO W73-02901) (SETTLE-WISCONSIN) JF - IN: IMMEDIATE COST-EFFECTIVE ABATEMENT OF WATER POLLUTION FROM NAVY SHIPS, NAVAL POSTGRADUATE SCHOOL, P 180-210, MARCH, 1972. 9 FIG, 2 TAB, 17 REF. AU - Hatleberg, C J AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *WATER POLLUTION KW - *WASTE WATER TREATMENT KW - SHIPS KW - COSTS KW - *BILGE WATER KW - BIOLOGICAL DEGRADATION KW - BILGE BALLAST TRANSFER KW - HARBOR DONUT KW - SW 3040:Wastewater treatment processes KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19272618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=CHARACTERIZATION+AND+TREATMENT+OF+BILGE+AND+BALLAST+WATER&rft.au=Hatleberg%2C+C+J&rft.aulast=Hatleberg&rft.aufirst=C&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - TOXICITY AND SPREADING OF OIL IN SEA WATER AN - 19271897; 7302903 AB - STUDIES CONDUCTED AFTER TWO MAJOR OPEN OCEAN OIL SPILLS INDICATE THAT THE DAMAGE TO THE BIOTA FROM THESE SPILLS WAS SLIGHT. ENVIRONMENTAL PROCESSES OPERATE TO RID THE OCEAN OF OIL POLLUTION IN A RELATIVELY SHORT PERIOD OF TIME. CONSEQUENTLY, A DILUTE, READILY DEGRADED FORM OF OIL SUCH AS THAT FOUND IN BILGE AND BALLAST EFFLUENTS NEED NOT BE TREATED ON BOARD SHIP BEFORE DISCHARGE INTO THE OPEN OCEAN. HOWEVER, A STUDY OF DILUTE EFFLUENT DISCHARGES INTO POORLY FLUSHED AREAS SUCH AS COASTAL OR HARBOR WATERS INDICATES THAT DISCHARGE CONCENTRATIONS AS LOW AS 20 PPM MAY BE TOXIC. THUS, BILGE AND BALLAST DISCHARGES IN CONFINED WATERS CAN BE HARMFUL TO THE ENVIRONMENT AND SHOULD BE TRANSFERRED ASHORE FOR TREATMENT. ON-BOARD TREATMENT SYSTEMS SUCH AS OIL-WATER SEPARATORS ARE THUS NOT NEEDED ON THE OPEN OCEAN AND NOT SUFFICIENT FOR IN-PORT NEEDS. AN INVESTIGATION OF THE SPREADING RATES FOR IN-PORT OIL SPILLS SUGGESTS THAT CONTAINMENT OF AN IN-PORT SPILL WILL BECOME EVEN MORE IMPERATIVE AS THE NAVY SWITCHES TO DISTILLATE FUEL. DISTILLATE IS MORE READILY INCORPORATED INTO THE WATER COLUMN AND CAN EXERT A MORE TOXIC EFFECT THAN PRESENT FUELS. (SEE ALSO W73-02901) (SETTLE-WISCONSIN) JF - IN: IMMEDIATE COST-EFFECTIVE ABATEMENT OF WATER POLLUTION FROM NAVY SHIPS, NAVAL POSTGRADUATE SCHOOL, P 102-147, MARCH, 1972. 5 FIG, 30 REF. AU - Barry, R F AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *TOXICITY KW - OCEANS KW - HARBORS KW - COASTS KW - WASTE TREATMENT KW - *BALLAST KW - *BILGE KW - SW 3070:Water quality control KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19271897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=TOXICITY+AND+SPREADING+OF+OIL+IN+SEA+WATER&rft.au=Barry%2C+R+F&rft.aulast=Barry&rft.aufirst=R&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - OIL SPILL CHARACTERISTICS AND STATISTICS AN - 19250467; 7302906 AB - BETWEEN JULY 1, 1966, AND SEPTEMBER 30, 1971, THERE WERE 593 OIL SPILLS REPORTED IN SAN DIEGO BAY. THE ESTIMATED COST OF CLEANING UP THESE SPILLS IS $256,187. SIXTY-FOUR PERCENT OF THESE SPILLS AND SIXTY-SEVEN PERCENT OF THE TOTAL COSTS OCCURRRED IN THE AREA OF THE NAVAL STATION. DESTROYER-TYPE SHIPS WERE RESPONSIBLE FOR ABOUT THIRTY-TWO PERCENT OF THE TOTAL SPILLS AND TWENTY-FOUR PERCENT OF THE COSTS. TENDERS AND REPAIR SHIPS INCURRED THE HIGHEST AVERAGE COST OF $1,381 FOR EACH SPILL, WHILE THE FUELING PIER AVERAGED $587 PER SPILL. A LINEAR REGRESSION BETWEEN CLEAN-UP COST AS THE DEPENDENT VARIABLE AND THE FREQUENCY OF OIL SPILLS AS THE INDEPENDENT VARIABLE GENERATED AN AVERAGE FREQUENCY OF OIL SPILLS OF 9.4, AN AVERAGE CLEAN-UP COST OF $4,066, AND A CORRELATION COEFFICIENT OF 0.73. THE DATA FURTHER INDICATES THAT A HIGH MONTHLY CLEAN-UP COST TENDS TO BE FOLLOWED BY DOWNWARD SLOPING COSTS FOR THE NEXT ELEVEN MONTHS AFTER WHICH COST STARTS TO SHARPLY INCREASE AGAIN. ONE POSSIBLE EXPLANATION FOR THIS PHENOMENON IS THE TRADITIONALLY HIGH SUMMER PERSONNEL TURNOVER RATES IN THE NAVY. REGRESSIONS OF COST ON TIME AND FREQUENCY ON TIME PRODUCED LOW CORRELATION COEFFICIENTS. (SEE ALSO W73-02901) (SETTLE-WISCONSIN) JF - IN: IMMEDIATE COST-EFFECTIVE ABATEMENT OF WATER POLLUTION FROM NAVY SHIPS, NAVAL POSTGRADUATE SCHOOL, P 211-231, MARCH, 1972. 2 FIG, 7 REF. AU - Lacey, J M AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *COSTS KW - FREQUENCY KW - REGRESSION ANALYSIS KW - STATISTICS KW - CLEANUP COSTS KW - SAN DIEGO BAY KW - SW 4030:Cost allocation, cost sharing, pricing KW - SW 3020:Sources and fate of pollution KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19250467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=OIL+SPILL+CHARACTERISTICS+AND+STATISTICS&rft.au=Lacey%2C+J+M&rft.aulast=Lacey&rft.aufirst=J&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THE CONTAINMENT AND RECOVERY OF NAVY OIL SPILLS--A FINANCIAL ANALYSIS AN - 19193903; 7302909 AB - THE THREE BASIC ALTERNATIVES BY WHICH THE U.S. NAVY CAN PROVIDE FOR THE CONTAINMENT AND RECOVERY OF ITS OIL SPILLS ARE (1) A COMPLETE NAVY IN-HOUSE CAPABILITY, (2) THE EXCLUSIVE USE OF CONTRACT SERVICES, AND (3) A COMBINATION OF NAVY AND CONTRACT SERVICES. THE COST OF CONTAINING AND RECOVERING U.S. NAVAL OIL SPILLS IN THE SAN DIEGO AREA UNDER THESE ALTERNATIVE APPROACHES IS ESTIMATED FOR THE TEN-YEAR PERIOD BEGINNING IN 1971. A PRESENT VALUE FIGURE FOR THESE COST FLOWS IS OBTAINED BY APPLYING THE STANDARD DEPARTMENT OF DEFENSE RATE OF TEN PERCENT. THE DISCOUNTED PRESENT COST OF A COMPLETE NAVY IN-HOUSE CAPABILITY IS ESTIMATED TO BE $2,470,020, WITH PERSONNEL COSTS REPRESENTING MORE THAN 75 PERCENT OF THIS TOTAL. THE PRESENT COST OF COMPLETE CONTRACT SERVICING FOR THE TEN-YEAR PERIOD IS ESTIMATED TO BE $686,300. THE TWO OTHER OPTIONS FOR WHICH DISCOUNTED PRESENT COST ESTIMATES ARE PROVIDED ARE (1) AN IN-HOUSE NAVY SYSTEM CAPABLE OF HANDLING SPILLS NOT EXCEEDING 100 GALLONS, UTILIZING CONTRACT SERVICES FOR LARGER SPILLS ($1,221,682); AND (2) THE DEVELOPMENT OF A NAVY OIL SPILL CONTAINMENT CAPABILITY, UTILIZING CONTRACT SERVICES FOR THE RECOVERY OF THE OIL ($1,237,135). (SEE ALSO W73-02901) (SETTLE-WISCONSIN) JF - IN: IMMEDIATE COST-EFFECTIVE ABATEMENT OF WATER POLLUTION FROM NAVY SHIPS, NAVAL POSTGRADUATE SCHOOL, P 293-312, MARCH, 1972. 5 TAB, 6 REF. AU - Anderson, R G AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *OIL POLLUTION KW - COSTS KW - WATER POLLUTION KW - *UNITED STATES NAVY KW - *FINANCIAL ANALYSIS KW - *CLEANUP COSTS KW - OIL CONTAINMENT KW - OIL RECOVERY KW - ALTERNATIVES KW - SW 4030:Cost allocation, cost sharing, pricing KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19193903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THE+CONTAINMENT+AND+RECOVERY+OF+NAVY+OIL+SPILLS--A+FINANCIAL+ANALYSIS&rft.au=Anderson%2C+R+G&rft.aulast=Anderson&rft.aufirst=R&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - AN OCEANOGRAPHIC INVESTIGATION OF THERMAL CHANGES IN MONTEREY BAY, CALIFORNIA, SEPTEMBER 1971 - JANUARY 1972 AN - 19103495; 7404223 AB - NINE OCEANOGRAPHIC STATIONS IN MONTEREY BAY WERE OCCUPIED ON AT LEAST WEEKLY INTERVALS FROM 21 SEPTEMBER 1971 THROUGH 28 JANUARY 1972. DURING THIS PERIOD THE THREE OCEANIC SEASONS DESCRIBED BY PREVIOUS INVESTIGATORS WERE OBSERVED. MEASURED THERMAL CONDITITIONS WERE COMPARED TO PREVIOUSLY DERIVED LONGTERM MEAN VALUES. THE MAGNITUDE OF THE SHORT-PERIOD THERMAL FLUCTUATIONS WAS COMPARABLE TO THAT NOTED IN EARLIER INVESTIGATIONS. THE CHANGES IN SEASONAL THERMAL STRUCTURE WERE GREATER AND MORE RAPID THAN CLIMATOLOGY IMPLIED. UNUSUALLY WEAK UPWELLING IN AUGUST 1971 WAS FOLLOWED IN OCTOBER BY STRONGER THAN NORMAL UPWELLING. THIS RESULTED IN AN INTERRUPTION IN THE OCEANIC PERIOD AND DELAYED THE START OF THE DAVIDSON CURRENT REGIME IN THE BAY. THE NETWORK OF REGULARLY OCCUPIED STATIONS WAS MORE EXTENSIVE THAN HAD BEEN PREVIOUSLY POSSIBLE. QUASI-SYNOPTIC OBSERVATIONS BETWEEN TWO OFFSHORE STATIONS INDICATED NORTH-SOUTH GEOSTROPHIC CURRENT VELOCITY COMPONENTS ON THE ORDER OF 2 TO 4 CM/SEC. (SINHA-OEIS) JF - AVAILABLE FROM NTIS AS AD-743 084 FOR $3.00 PAPER COPY, $1.45 MICROFICHE. MS THESIS, MARCH 1972. 101 P, 52 FIG, 12 REF. AU - McClelland, J J AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *CALIFORNIA KW - *UPWELLING KW - *CURRENTS(WATER) KW - *COASTS KW - *WATER TEMPERATURE KW - SEASONAL KW - ISOTHERMS KW - MONTEREY BAY(CA) KW - DAVIDSON CURRENT KW - *SEA SURFACE TEMPERATURE KW - THERMAL STRUCTURE KW - GEOSTROPHIC CURRENTS KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19103495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=AN+OCEANOGRAPHIC+INVESTIGATION+OF+THERMAL+CHANGES+IN+MONTEREY+BAY%2C+CALIFORNIA%2C+SEPTEMBER+1971+-+JANUARY+1972&rft.au=McClelland%2C+J+J&rft.aulast=McClelland&rft.aufirst=J&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - FINE STRUCTURE MEASUREMENT OF TEMPERATURE AND MOISTURE OVER THE MONTEREY BAY AN - 19093052; 7404222 AB - TEMPERATURE, PRESSURE AND MOISTURE MEASUREMENTS WERE MADE FROM THE SURFACE TO 2,000 FT OVER THE MONTEREY BAY DURING SEVERAL DIFFERENT SYNOPTIC CONDITIONS. DATA COLLECTION WAS MADE FROM GROUND LEVEL AND A HELICOPTER. THERE ARE MANY SMALL SCALE FLUCTUATIONS IN THE FINE STRUCTURE OF THE LOWER LAYERS OF THE ATMOSPHERE THAT AFFECT THE FORMATION OF FOG IN SMALL LOCALIZED AREAS. THE DATA INDICATE A CLOSE RELATIONSHIP BETWEEN THE INVERSION LAYER AND FOG FORMATION; FOR EXAMPLE, FOG FORMATION OCCURRED AT THE BASE OF THE INVERSION ON FOUR DIFFERENT PROFILES. EVIDENTLY, FOG IS NOT TRIGGERED BY A LARGE CHANGE IN ONE OF ITS ASSOCIATED PARAMETERS, BUT RATHER BY VERY SMALL CHANGES IN ONE OR SEVERAL OF THESE PARAMETERS. THESE SMALL CHANGES MAY BE LOCAL AND SHORTLIVED RESULTING IN LIMITED FOG, OR THEY MAY BE OF SYNOPTIC SCALE AND RESULT IN WIDE-SPREAD FOG. LARGE AREAS IN WHICH FOG IS PREVALENT CAN NORMALLY BE PREDICTED FROM THE DAILY UPPER SOUNDINGS NOW AVAILABLE; HOWEVER, MORE KNOWLEDGE AND DATA ON A FINER SCALE APPEARS TO BE NECESSARY TO PREDICT FOG ACCURATELY ON A LOCAL BASIS. (SINHA-OEIS) JF - AVAILABLE FROM NTIS AS AD-743 702 FOR $3.00 PAPER COPY, $1.45 MICROFICHE. MS THESIS, MARCH 1972. 102 P, 43 FIG, 23 TAB, 5 REF, APPEND. AU - Colvert, L R AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *CALIFORNIA KW - *FOG KW - *PREDICTION KW - *MOISTURE KW - *AIR TEMPERATURE KW - TEMPERATURE KW - ATMOSPHERIC PRESSURE KW - WEATHER KW - MEASURING INSTRUMENTS KW - DATA REDUCTION KW - METEOROLOGICAL DATA KW - VISIBILITY KW - INVERSION KW - CLOUD COVER KW - AIR-WATER INTERFACES KW - MONTEREY BAY(CA) KW - *FOG BANK KW - VERTICAL PROFILES KW - MIXING RATIO KW - UPPER AIR SOUNDINGS KW - *STRATUS CLOUDS KW - SW 0815:Precipitation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19093052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=FINE+STRUCTURE+MEASUREMENT+OF+TEMPERATURE+AND+MOISTURE+OVER+THE+MONTEREY+BAY&rft.au=Colvert%2C+L+R&rft.aulast=Colvert&rft.aufirst=L&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A DESCRIPTION OF THE EPRF HYDRODYNAMICAL-NUMERICAL MODEL AN - 19054561; 7306355 AB - AN OPERATIONAL DESCRIPTION IS PROVIDED OF THE ENVIRONMENTAL PREDICTION RESEARCH FACILITY'S SINGLE-LAYER HYDRODYNAMICAL--NUMERICAL (H--N) MODEL THAT HAS BEEN USED FOR A VARIETY OF LOCAL OCEANOGRAPHIC ANALYSES AND PREDICTIONS. THE MODEL IS AN ADAPTATION OF THE ONE FORMULATED BY WALTER HANSEN, UNIVERSITY OF HAMBURG, WHO DEVELOPED AND TESTED HIS OVER TWO DECADES. THE DESCRIPTION INCLUDES THE SETTING-UP OF THE MODEL FOR A GIVEN AREA AND THE SELECTION AND PREPARATION OF INPUT DATA. A BRIEF BACKGROUND OF THE HYDRODYNAMICAL FORMULAS AND THEIR FINITE DIFFERENCE FORMS IS GIVEN. LATEST ADDITIONS TO THE MODEL ARE DOCUMENTED, SUCH AS DIFFUSION AND TRANSPORT COMPUTATIONS, AND TREATMENT OF OPEN BOUNDARIES: THE MODEL IS BEST SUITED TO SHALLOW SEMICLOSED BAYS AND ESTUARIES BUT CAN ALSO BE USED WITH THREE OPEN BOUNDARIES FOR ANY COASTAL AREA; TWO DIFFERENT APPLICATIONS OF THIS FEATURE ARE DESCRIBED. ANOTHER NEW FEATURE MAKES POSSIBLE THE INCLUSION OF THE PERMANENT (THERMOHALINE COMPONENT) CURRENT AS WELL AS TIDAL AND WIND CURRENTS. THE MODEL HAS BEEN USED FOR ANALYSIS AND PREDICTION OF TIDES, STORM SURGES, CURRENTS, DIFFUSION AND TRANSPORT OF POLLUTANTS AND OIL, AND DRIFT OF BOATS FOR SEARCH AND RESCUE PURPOSES. THE COMPUTER PROGRAM IS WRITTEN IN FORTRAN II. (SEE ALSO W73-06356) (BELL-CORNELL) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-745 759, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. ENVPREDRSCHFAC TECHNICAL PAPER NO 3--72, MARCH 1972. 49 P, 12 FIG, 16 REF. AU - LAEVASTU, T AU - Rabe, K AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *HYDRODYNAMICS KW - *OCEANOGRAPHY KW - *COMPUTER PROGRAMS KW - ANALYSIS KW - TIDES KW - STORM SURGE KW - OIL KW - POLLUTANTS KW - DISPERSION KW - DIFFUSION KW - OCEAN CURRENTS KW - WINDS KW - BOATS KW - ATMOSPHERIC PRESSURE KW - OCEANS KW - BAYS KW - ESTUARIES KW - COASTS KW - SYSTEMS ANALYSIS KW - MATHEMATICAL MODELS KW - MODEL STUDIES KW - *PREDICTION KW - *FINITE DIFFERENCE FORMS KW - *OPEN BOUNDARIES KW - COMPUTATION KW - SEARCH AND RESCUE KW - SW 0810:General KW - SW 3020:Sources and fate of pollution KW - SW 4010:Techniques of planning KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19054561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+DESCRIPTION+OF+THE+EPRF+HYDRODYNAMICAL-NUMERICAL+MODEL&rft.au=LAEVASTU%2C+T%3BRabe%2C+K&rft.aulast=LAEVASTU&rft.aufirst=T&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - REDUCTION OF OIL SPILLS DURING SHIPBOARD FUEL MOVEMENT EVOLUTIONS AN - 19053956; 7302907 AB - THE CAUSES OF NAVY OIL SPILLS DURING FUEL MOVEMENT EVOLUTIONS ARE CATEGORIZED INTO THREE SUBGROUPS: INDICATION, CONTROL, AND OTHER. THE CONTROL SUBGROUP CONTAINS THOSE CAUSES WHICH COULD HAVE BEEN ELIMINATED IF A POSITIVE MEANS OF CONTROL OF THE FUELING EVOLUTION HAD BEEN EMPLOYED. THE INDICATION SUBGROUP IS COMPRISED OF CAUSES BROUGHT ABOUT BY AN INADEQUATE TANK LEVEL INDICATING SYSTEM. THESE TWO SUBGROUPS COMBINED ACCOUNT FOR 77.9 PERCENT OF THE OIL SPILLS FOR ALL NAVY SHIPS IN THE SAMPLE. THE TWO SUBGROUPS ACCOUNT FOR 91.1 PERCENT OF OIL SPILLS FROM DESTROYERS. THESE SPILLS COULD BE NEARLY ELIMINATED THROUGH THE ADOPTION OF EITHER ONE OF TWO SOLUTIONS. THE INDIRECT APPROACH WOULD ATTEMPT TO ELIMINATE THE CAUSES THAT LEAD TO OVERFILLED TANKS BY PROVIDING INSTRUMENTATION OF ALL FUEL OIL TANKS WHICH OVERFLOW OVERBOARD. THE DIRECT APPROACH WOULD ATTEMPT TO MINIMIZE THE POSSIBILITY OF OVERFILLING TANKS. IT WOULD REDUCE THE NUMBER OF TANKS THAT OVERFLOW OVERBOARD BY INTERNALLY REROUTING OVERFLOW LINES TO DESIGNATED OVERFLOW TANKS, WHICH WOULD HAVE EXTERNAL OVERFLOW LINES, AND THEN INSTRUMENTING THESE TANKS. THE DIRECT METHOD IS RECOMMENDED FOR DESTROYERS SINCE ITS MAXIMUM IMPLEMENTATION COST IS $5.5 MILLION, WHILE THE INDIRECT METHOD WOULD COST ABOUT $6.2 MILLION PER DESTROYER. (SEE ALSO W73-02901) (SETTLE-WISCONSIN) JF - IN: IMMEDIATE COST-EFFECTIVE ABATEMENT OF WATER POLLUTION FROM NAVY SHIPS, NAVAL POSTGRADUATE SCHOOL, P 232-256, MARCH, 1972. 2 FIG, 5 TAB, 8 REF. AU - Greene, J B AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *OIL POLLUTION KW - *FUELS KW - *EVOLUTION KW - CONTROL KW - SHIPS KW - INDICATORS KW - COSTS KW - *FUEL MOVEMENT EVOLUTION KW - *FUEL OIL KW - CAUSES KW - PREVENTION KW - PREVENTION COSTS KW - SW 3020:Sources and fate of pollution KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19053956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=REDUCTION+OF+OIL+SPILLS+DURING+SHIPBOARD+FUEL+MOVEMENT+EVOLUTIONS&rft.au=Greene%2C+J+B&rft.aulast=Greene&rft.aufirst=J&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THE VERTICAL MOVEMENT OF OIL IN SEAWATER AND THE AGING OF OIL SLICKS AN - 19051370; 7302904 AB - MAN-MADE TURBULENCE GENERATED BY IMPROPER OIL SPILL CONTROL TECHNIQUES CAN DRIVE SIGNIFICANT AMOUNTS OF OIL DEEP INTO THE WATER COLUMN WHERE IT MAY HAVE SERIOUS TOXIC EFFECTS. A SIMULATED FIRE HOSE DIRECTED ON SLICKS OF THREE COMMON NAVY FUEL OILS DROVE WATER EMULSIONS TO THE BOTTOM OF A 68 CM DEEP TEST TANK WITHIN 30 SECONDS. A FLUORIMETER MONITORING OF THIS EMULSION OVER A THREE-DAY PERIOD INDICATED ITS RELATIVE STABILITY. OF THE NATURAL TURBULENCE-CAUSING MECHANISMS, ONLY WHITECAPS AND BREAKING WAVES NORMALLY POSSESS SUFFICIENT INTENSITY TO FORM STABLE OIL-WATER EMULSIONS. SINCE THESE NATURAL MECHANISMS ARE NOT NORMALLY FOUND IN HARBORS, ALLOWING A SLICK TO SPREAD UNTIL GENTLE CONTROL MEASURES WERE AVAILABLE MAY DISPERSE SMALLER AMOUNTS OF TOXIC OIL THROUGHOUT THE WATER THAN IMMEDIATELY 'HERDING' AN OIL SLICK WITH FIRE HOSES. A SEPARATE EXPERIMENT WITH THE AGING OF FOUR NAVY OILS INDICATED THAT EXPOSURE TO THE ATMOSPHERE PRODUCES SELECTIVE EVAPORATION OF OIL CONSTITUENTS, THUS PERMITTING COMPARATIVE AGE DATING OF SLICKS FROM GAS CHROMATOGRAPH TRACES. THIS COMPARATIVE DATING IS POSSIBLE EVEN THOUGH A NUMBER OF FACTORS PREVENT PREDICTION OF THE ABSOLUTE RATIOS OF CONSTITUENTS TO BE EXPECTED AT A GIVEN TIME. SUCH DATING MAY HELP IN ASSIGNING RESPONSIBILITY FOR OIL SPILLS. (SEE ALSO W73-02901) (SETTLE-WISCONSIN) JF - IN: IMMEDIATE COST-EFFECTIVE ABATEMENT OF WATER POLLUTION FROM NAVY SHIPS, NAVAL POSTGRADUATE SCHOOL, P 148-179, MARCH, 1972. 7 FIG, 16 REF. AU - Peterson, R S AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *EMULSIONS KW - WAVES(WATER) KW - AGE KW - MECHANICAL MIXING KW - FIRE HOSES KW - HERDING KW - SW 3020:Sources and fate of pollution KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19051370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THE+VERTICAL+MOVEMENT+OF+OIL+IN+SEAWATER+AND+THE+AGING+OF+OIL+SLICKS&rft.au=Peterson%2C+R+S&rft.aulast=Peterson&rft.aufirst=R&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - LOCATION AND EQUIPMENT FOR OIL RECOVERY TEAMS IN SAN DIEGO AN - 19038406; 7302910 AB - A MATHEMATICAL PROGRAMMING TECHNIQUE IS APPLIED TO DATA ON SAN DIEGO OIL SPILLS IN ORDER TO DETERMINE THE MOST EFFECTIVE LOCATIONS AT WHICH OIL RECOVERY TEAMS SHOULD BE STATIONED. FOUR SAN DIEGO NAVAL FACILITIES WERE CONSIDERED AS POTENTIAL SITES FOR RECOVERY TEAMS: CHOLLAS CREEK AT THE NAVAL STATION, THE NAVAL AIR STATION NORTH ISLAND, THE NAVAL ELECTRONICS LABORATORY PIER AT FLEET TRAINING GROUP, AND THE FUEL PIER. THE OVERALL EFFECTIVENESS OF THE RECOVERY TEAMS IS MAXIMIZED WHEN TEAMS ARE STATIONED AT ALL FOUR LOCATIONS. FOUR TEAMS WOULD BE ABOUT THREE TIMES AS EFFECTIVE AS ONE TEAM LOCATED AT THE BEST SINGLE LOCATION, THE NAVAL STATION. THE OVERALL EFFECTIVENESS IS IMPROVED BY NEARLY A THIRD OVER THAT OF A SINGLE TEAM LOCATION WHEN A SECOND TEAM IS BASED AT NORTH ISLAND. DEPLOYMENT OF A THIRD TEAM TO THE FUEL PIER RESULTS IN ANOTHER SUBSTANTIAL INCREASE IN OVERALL EFFECTIVENESS. HOWEVER, PLACING A FOURTH TEAM AT THE LABORATORY PIER IMPROVES SYSTEM EFFECTIVENESS BY LESS THAN 3 PERCENT. CONSEQUENTLY, THIS FOURTH DEPLOYMENT IS NOT RECOMMENDED. SEVERAL DEVICES AND METHODS FOR OIL SPILL CONTROL ARE EXAMINED INCLUDING CONTAINMENT BOOMS, SORBING AND GELLING AGENTS, PHYSICAL RETRIEVAL DEVICES, CHEMICAL DISPERSION, SINKING AGENTS, BURNING, AND BIODEGRADATION. (SEE ALSO W73-02901) (SETTLE-WISCONSIN) JF - IN: IMMEDIATE COST-EFFECTIVE ABATEMENT OF WATER POLLUTION FROM NAVY SHIPS, NAVAL POSTGRADUATE SCHOOL, P 313-337, MARCH, 1972. 5 TAB, 15 REF. AU - Murphy, C R AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *OIL SPILLS KW - *OIL POLLUTION KW - *CONTROL KW - TIME KW - DISTANCE KW - *OIL RECOVERY TEAMS KW - *LOCATION KW - *COST EFFECTIVENESS KW - OIL CONTROL KW - OIL CONTROL METHODS KW - SW 4030:Cost allocation, cost sharing, pricing KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19038406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=LOCATION+AND+EQUIPMENT+FOR+OIL+RECOVERY+TEAMS+IN+SAN+DIEGO&rft.au=Murphy%2C+C+R&rft.aulast=Murphy&rft.aufirst=C&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SHIPBOARD CONTROL OF WASTES AN - 19038358; 7302902 AB - THE THREE BASIC WAYS OF DISPOSING OF SANITARY WASTES GENERATED ABOARD U.S. NAVY SHIPS ARE (1) TREATMENT ON-BOARD AND DISCHARGE INTO THE ENVIRONMENT, (2) HOLD ON-BOARD FOR DISCHARGE INTO OPEN WATERS OR OFF-SHIP RECEIVING FACILITIES, AND (3) DISCHARGE DIRECTLY INTO CONNECTIONS TO OFF-SHIP FACILITIES. OF THE FOURTEEN ON-BOARD TREATMENT SYSTEMS THAT HAVE BEEN TESTED AND EVALUATED, NONE COULD SATISFACTORILY MEET ENVIRONMENTAL PROTECTION AGENCY STANDARDS OR SATISFY THE RIGOROUS REQUIREMENTS OF SHIPBOARD OPERATIONS. THE CONCEPT OF A CENTRALIZED HOLDING TANK LEADS TO EXTENSIVE AND COSTLY INTERIOR MODIFICATION OF EXISTING SHIP STRUCTURES AND CREATES SUCH POTENTIAL PROBLEMS AS SPACE LIMITATIONS ABOARD THE VESSEL AND DECREASED OPERATIONAL RANGE IF FUEL TANKS ARE CONVERTED INTO HOLDING TANKS. CONSEQUENTLY, CENTRALIZED HOLDING SYSTEMS SHOULD NOT BE INSTALLED ON EXISTING VESSELS, ALTHOUGH THEY MAY BE DESIRABLE IF DESIGNED AS AN INTEGRAL PART OF NEW SHIPS. SANITARY WASTES CAN BE EFFICIENTLY AND CHEAPLY TRANSFERRED TO OFF-SHIP FACILITIES THROUGH A SHIPBOARD SEWAGE TRANSFER ASSEMBLY UNIT. AN EXAMINATION OF ALTERNATIVE OFF-SHIP RECEIVING FACILITIES SUGGESTS THAT THE ULTIMATE RECEIVING FACILITY SHOULD BE PIERSIDE SEWERS. UNTIL SUCH SEWERS ARE CONSTRUCTED, BARGES OR PORTABLE CONTAINERS REPRESENT POSSIBLE ALTERNATIVE RECEPTACLES. (SEE ALSO W73-02901) (SETTLE-WISCONSIN) JF - IN: IMMEDIATE COST-EFFECTIVE ABATEMENT OF WATER POLLUTION FROM NAVY SHIPS, NAVAL POSTGRADUATE SCHOOL, P 15-101, MARCH, 1972. 1 FIG, 13 TAB, 54 REF. AU - Sanders, G A AU - Stuhlman, R H AU - Swientek, F M AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972/03// PY - 1972 DA - Mar 1972 KW - Water Resources Abstracts KW - *SEWERAGE KW - *SHIPS KW - *WASTE DISPOSAL KW - WASTE TREATMENT KW - TREATMENT FACILITIES KW - COSTS KW - *SANITARY SEWAGE KW - ON-SHIP TREATMENT KW - OFF-SHIP TREATMENT KW - SW 3040:Wastewater treatment processes KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19038358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SHIPBOARD+CONTROL+OF+WASTES&rft.au=Sanders%2C+G+A%3BStuhlman%2C+R+H%3BSwientek%2C+F+M&rft.aulast=Sanders&rft.aufirst=G&rft.date=1972-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - INFORMATION SYSTEMS AND DATA REQUIREMENTS: COASTAL DEVELOPMENT PLANNING AN - 19052010; 7210582 AB - THE MAJOR REQUIREMENT FOR THE DEVELOPMENT OF A COASTAL ZONE DATA NETWORK IS THE CENTRALIZATION OF STORAGE AND PROCESSING WITHIN EACH STATE AND THE PROVISION OF INTERFACES AMONG FEDERAL, STATE, AND COASTAL ZONE SYSTEMS SO THAT GREATER COORDINATION AND STANDARDIZATION OF DATA COLLECTION AND PROCESSING MAY RESULT. THE RESULTING COASTAL ZONE NETWORK COULD BE CHARACTERIZED AS A MODERATELY CENTRALIZED INTRASTATE SYSTEM, BUT AS A HIGHLY DECENTRALIZED INTERSTATE SYSTEM. SOME OF THE MEASURES WHICH ARE NEEDED TO DEVELOP A COASTAL ZONE DATA NETWORK ARE: (1) DEVELOPMENT AND MAINTENANCE OF AN INVENTORY OF COASTAL ZONE DATA, (2) ESTABLISHMENT OF INTERSTATE AND INTRASTATE DATA FORMAT AND TRANSMISSION STANDARDS, (3) ESTABLISHMENT IN THE STATES OF AN ORGANIZATIONAL STRUCTURE FOR FACILITATING THE EXCHANGE OF DATA AMONG LOCAL, STATE, AND FEDERAL AGENCIES AND THE PRIVATE SECTOR, (4) ESTABLISHMENT OF A CENTRAL DATA CENTER IN EACH STATE UNDER STATE CONTROL, (5) DEVELOPMENT OF A CONSISTENT METHOD FOR INDEXING AND STORING THE DATA, (6) STORAGE OF DATA IN A FORM WHICH IS AN ANALOG OF THE COASTAL ZONE FOR THE PURPOSES OF EFFICIENCY OF RETRIEVAL AND THE DEVELOPMENT OF COASTAL ZONE MODELS, AND (7) ESTABLISHMENT OF COASTAL ZONE DATA SYSTEMS, IN SUCH AREAS AS WATER QUALITY, FISHERIES, COASTAL ENGINEERING, AND WEATHER MONITORING AND FORECASTING AS PART OF A LARGER COASTAL ZONE DATA NETWORK. (SEE ALSO W72-10575) (STRACHAN-CHICAGO) JF - IN: COASTAL ZONE MANAGEMENT: MULTIPLE USE WITH CONSERVATION, UNIVERSITY OF CALIFORNIA ENGINEERING AND PHYSICAL SCIENCES EXTENSION SERIES, JOHN WILEY AND SONS, INC., NEW YORK, N.Y. 1972. P 221-244. 3 FIG, 14 REF. AU - Schneidewind, N F AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1972 PY - 1972 DA - 1972 KW - Water Resources Abstracts KW - *PLANNING KW - *DATA COLLECTIONS KW - *NETWORKS KW - DATA STORAGE AND RETRIEVAL KW - DATA TRANSMISSION KW - MAINTENANCE KW - MANAGEMENT KW - *COASTAL DEVELOPMENT PLANNING KW - *INFORMATION SYSTEMS KW - *DATA REQUIREMENTS KW - *CENTRALIZATION KW - STANDARDIZATION KW - SW 5010:Network design KW - SW 4070:Ecological impact of water development KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19052010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=INFORMATION+SYSTEMS+AND+DATA+REQUIREMENTS%3A+COASTAL+DEVELOPMENT+PLANNING&rft.au=Schneidewind%2C+N+F&rft.aulast=Schneidewind&rft.aufirst=N&rft.date=1972-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - OPTICAL SIGNATURES OF THE NEAR-SHORE WATERS OF SOUTHERN MONTEREY BAY AN - 19060669; 7302027 AB - A STUDY WAS MADE TO RELATE CERTAIN OPTICAL PROPERTIES WITH OTHER OBSERVED PROPERTIES OF WATER SAMPLED IN SOUTHERN MONTEREY BAY, CALIFORNIA. DOMINANT WAVELENGTH, PERCENT PURITY, AND VISUAL EFFICIENCY WERE DETERMINED FOR 65 NEAR-SHORE WATER SAMPLES USING A ONE-METER SAMPLE CELL IN A MODIFIED BECKMAN DU-2 SPECTROPHOTOMETER. MEASUREMENTS MADE AT THE SAMPLE LOCATIONS INCLUDED SALINITY, SURFACE TEMPERATURE, PHOSPHATE, COLIFORM COUNT, OXYGEN, AND PARTICLE SIZE DISTRIBUTION IN THE 1.04 MICRON TO 27.6 MICRONS DIAMETER RANGE. MOST OF THE SAMPLING WAS DONE AT OR NEAR THE MONTEREY SEWAGE OUTFALL. DOMINANT WAVELENGTHS WERE FOUND TO VARY BETWEEN 520 NM AND 585 NM. PERCENT PURITY WAS FOUND TO FLUCTUATE BETWEEN 2 AND 40 PERCENT. NEITHER VARIABLE SEEMS TO BE STRONGLY SENSITIVE TO VARIATION IN TREATED SEWAGE CONCENTRATION FOR THE MONTEREY OUTFALL. DOMINANT WAVELENGTH FOR EACH OF THE 21 FOREL-ULE SCALE COLORS WAS MEASURED SPECTROPHOTOMETRICALLY AND COMPARED WITH THE DOMINANT WAVELENGTHS OF THE SAMPLES. IT IS CONCLUDED THAT DOMINANT WAVELENGTH, PERCENT PURITY, AND PARTICLE AREA OR VOLUME ARE POOR SIGNATURES OF SEWAGE EFFLUENT FROM THE STANDPOINT OF OBSERVING (VISUALLY) EFFLUENT DISTRIBUTIONS AND CONCENTRATIONS. (LITTLE-BATTELLE) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-741 144, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MASTER'S THESIS, DECEMBER 1971. 127 P, 4 TAB, 9 REF. AU - Potts, J R AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/12// PY - 1971 DA - Dec 1971 KW - Water Resources Abstracts KW - *OPTICAL PROPERTIES KW - *SALINITY KW - *PHOSPHATES KW - *COLIFORMS KW - *DISSOLVED OXYGEN KW - *PARTICLE SIZE KW - *SEWAGE EFFLUENTS KW - *MONITORING KW - WATER ANALYSIS KW - SPECTROPHOTOMETRY KW - REGRESSION ANALYSIS KW - COLOR KW - WATER QUALITY KW - WATER TEMPERATURE KW - NUTRIENTS KW - TURBIDITY KW - WATER POLLUTION EFFECTS KW - STATISTICAL METHODS KW - TRANSMITTANCE KW - *MONTEREY BAY(CALIF) KW - SW 3010:Identification of pollutants KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19060669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=OPTICAL+SIGNATURES+OF+THE+NEAR-SHORE+WATERS+OF+SOUTHERN+MONTEREY+BAY&rft.au=Potts%2C+J+R&rft.aulast=Potts&rft.aufirst=J&rft.date=1971-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - AN ANALYSIS OF THE CONCENTRATIONS OF HEAVY METALS IN MONTEREY HARBOR UTILIZING THE METHODS OF ATOMIC ABSORPTION SPECTROPHOTOMETRY AND POLAROGRAPHY AN - 19056779; 7214964 AB - IN 1972 OR 1973 CONSTRUCTION MAY BEGIN ON A BREAKWATER TO BE LOCATED OFF OF DEL MONTE BEACH NORTH AND EAST OF THE PRESENT MUNICIPAL WHARF NO. 2 IN MONTEREY, CALIFORNIA. FACULTY AND STUDENTS OF THE NAVAL POSTGRADUATE SCHOOL HAVE UNDERTAKEN TO DESCRIBE THE ECOLOGY OF THIS AREA BEFORE CONSTRUCTION BEGINS. ECOLOGICAL BASE LINES IN THE UNDISTURBED AREA WILL BE ESTABLISHED SO THAT ENVIRONMENTAL CHANGES BROUGHT ABOUT BY HARBOUR CONSTRUCTION CAN BE EVALUATED. AS PART OF THIS STUDY, WATER SAMPLES WERE TAKEN AT SELECTED STATIONS AND ANALYZED FOR THE HEAVY METALS COBALT, COPPER, IRON, LEAD, AND NICKEL BY ATOMIC ABSORPTION SPECTROSCOPY AND BY POLAROGRAPHY. THE RESULTS OBTAINED BY THESE TWO METHODS ARE COMPARED AND DISCUSSED. THE HEAVY METALS IN THE SEA WATER WERE CONCENTRATED AND REMOVED USING THE AMMONIUM PYRROLIDINE DITHIOCARBAMATE (APDC) -- METHYL ISOBUTYL KETONE (MIBK) SOLVENT EXTRACTION METHOD. THE CONCENTRATIONS OF THE METALS WERE DETERMINED USING ATOMIC ABSORPTION SPECTROPHOTOMETRY. THE APDC-MIBK SOLVENT EXTRACTION METHOD WAS NOT ADEQUATE FOR ANALYSIS BY POLAROGRAPHY. (WOODARD-USGS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-738 889, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. M SC THESIS, NAVAL POSTGRADUATE SCHOOL, DECEMBER 1971. 41 P, 6 FIG, 3 TAB, 15 REF. AU - Tanner, J W AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/12// PY - 1971 DA - Dec 1971 KW - Water Resources Abstracts KW - *CHEMICAL ANALYSIS KW - *HEAVY METALS KW - *SEA WATER KW - *COASTS KW - *CALIFORNIA KW - ANALYTICAL TECHNIQUES KW - HARBORS KW - SPECTROPHOTOMETRY KW - POLAROGRAPHIC ANALYSIS KW - EVALUATION KW - METHODOLOGY KW - BREAKWATERS KW - ENVIRONMENTAL EFFECTS KW - ECOLOGY KW - SAMPLING KW - COBALT KW - COPPER KW - IRON KW - LEAD KW - NICKEL KW - PRE-CONSTRUCTION STUDY KW - SW 0880:Chemical processes KW - SW 3010:Identification of pollutants KW - SW 3070:Water quality control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19056779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=AN+ANALYSIS+OF+THE+CONCENTRATIONS+OF+HEAVY+METALS+IN+MONTEREY+HARBOR+UTILIZING+THE+METHODS+OF+ATOMIC+ABSORPTION+SPECTROPHOTOMETRY+AND+POLAROGRAPHY&rft.au=Tanner%2C+J+W&rft.aulast=Tanner&rft.aufirst=J&rft.date=1971-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - AN INVESTIGATION INTO THE EFFECT OF AN INDUSTRIAL HEAT AND MOISTURE SOURCE ON LOCAL ATMOSPHERIC CONDITIONS AN - 19288395; 7213313 AB - USING A STEAM GENERATING PLANT AS THE SOURCE, AN INVESTIGATION WAS MADE INTO THE LOCAL ATMOSPHERIC EFFECT OF A LARGE INDUSTRIAL HEAT AND MOISTURE SOURCE. MEASUREMENTS WERE MADE ON THE CALIFORNIA COAST WHERE THERE ARE COMMON AND PERSISTENT INVERSIONS. DATA COLLECTION WAS ATTEMPTED WITH GROUND- AND HELICOPTERBORNE EQUIPMENT WITH A FINAL RESORT TO THE HELICOPTER WHEN THE GROUND EQUIPMENT COLLECTION TECHNIQUES PROVED UNSATISFACTORY. TEMPERATURES, VAPOR PRESSURES, AND HUMIDITY WERE MEASURED. MIXING RATIOS WERE GENERATED AND VERTICAL CROSS SECTIONS OF TEMPERATURE AND MIXING RATIO WERE USED TO DISPLAY THE DATA. THE EFFECT OF EMISSIONS FROM A STEAM POWER PLANT APPEARS TO BE VERY STRONGLY TIED TO THE POSITION OF THE INVERSION WITH RESPECT TO STACK HEIGHT AND ALSO TO CLOUD STRUCTURE, IF CLOUDS ARE PRESENT. IF THE INVERSION IS ABOVE STACK LEVEL, THE BASE APPEARS TO BE LOWERED IN THE VICINITY OF THE SOURCE. IF CLOUDS ARE PRESENT, THE EMITTED MOISTURE TENDS TO THICKEN THE CLOUDS OR AT LEAST LOWER THE CLOUD BASES AND PROBABLY THE ASSOCIATED INVERSION. IF THE INVERSION BASE IS BELOW THE STACK LEVEL OR THERE IS NO INVERSION, THEN IT APPEARS THAT THE WIND REGIME BECOMES IMPORTANT. IT IS APPARENT THAT THE ATMOSPHERIC MOISTURE CONTENT IS MUCH MORE SENSITIVE TO THE DISCHARGES OF THE STACKS THAN IS THE TEMPERATURE STRUCTURE. (EAGLE-VANDERBILT) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-733 227, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. M.S. THESIS, SEPTEMBER 1971. 78 P, 40 FIG, 2 TAB, 7 REF. AU - Draft, J C AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/09// PY - 1971 DA - Sep 1971 KW - Water Resources Abstracts KW - *MOISTURE KW - *HEAT KW - *METEOROLOGY KW - *THERMAL POWERPLANTS KW - *AIR POLLUTION KW - *THERMAL POLLUTION KW - INDUSTRIAL WASTES KW - ATMOSPHERE KW - TEMPERATURE KW - HUMIDITY KW - VAPOR PRESSURE KW - HELICOPTER AEROGRAPH KW - INVERSION KW - SW 3020:Sources and fate of pollution KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19288395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=AN+INVESTIGATION+INTO+THE+EFFECT+OF+AN+INDUSTRIAL+HEAT+AND+MOISTURE+SOURCE+ON+LOCAL+ATMOSPHERIC+CONDITIONS&rft.au=Draft%2C+J+C&rft.aulast=Draft&rft.aufirst=J&rft.date=1971-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SUBLITTORAL ECOLOGY OF THE KELP BEDS OFF DEL MONTE BEACH, MONTEREY, CALIFORNIA AN - 19053407; 7212670 AB - MACROSCOPIC ORGANISMS COLLECTED BY SCUBA DIVERS THROUGHOUT A LARGE PORTION OF THE KELP BEDS AT DEL MONTE BEACH, MONTEREY, CALIFORNIA, WERE IDENTIFIED AND A LIST OF SPECIES PRESENT WAS COMPILED. MORE THAN 160 SUCH SPECIES WERE FOUND TO EXIST. COLLECTION METHODS AND TECHNIQUES UTILIZED BY DIVERS WERE DOCUMENTED. NUMEROUS UNDERWATER PHOTOGRAPHS WERE TAKEN. A POPULATION CENSUS AND MAPPING SURVEY WAS MADE BY DIVERS OF THE BENTHIC FLORA AND FAUNA EXISTING WITHIN TWO PERMANENTLY MARKED BOTTOM AREAS, ONE OF WHICH IS TO BE EVENTUALLY ISOLATED FROM THE OPEN SEA BY ERECTION OF A BREAKWATER. THE AREAS WERE FOUND TO BE OF GENERALLY SIMILAR BIOLOGICAL POPULATION, BUT OF MARKEDLY DIFFERENT SPECIES DISTRIBUTION AND RELATIVE ABUNDANCE. (KATZ-WASHINGTON) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-738 875, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MASTER'S THESIS, SEPTEMBER 1971. 181 P, 102 FIG, 31 REF, 2 APP. AU - MINTER, CSIII AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/09// PY - 1971 DA - Sep 1971 KW - Water Resources Abstracts KW - *BASELINE STUDIES KW - *KELPS KW - *BIOLOGICAL COMMUNITIES KW - *CALIFORNIA KW - BENTHOS KW - ECOSYSTEMS KW - AQUATIC HABITAT KW - FOOD CHAINS KW - AQUATIC POPULATIONS KW - *BENTHIC ECOLOGY KW - *SCUBA KW - *DIVING KW - *MARINE ECOLOGY KW - KELP BEDS KW - MARINE BENTHOS KW - UNDERWATER STUDIES KW - HARBOR ECOLOGY KW - MONTEREY BREAKWATER STUDY KW - SW 3010:Identification of pollutants KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19053407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SUBLITTORAL+ECOLOGY+OF+THE+KELP+BEDS+OFF+DEL+MONTE+BEACH%2C+MONTEREY%2C+CALIFORNIA&rft.au=MINTER%2C+CSIII&rft.aulast=MINTER&rft.aufirst=CSIII&rft.date=1971-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SUSPENDED MATTER IN MONTEREY BAY, CALIFORNIA: SOME ASPECTS OF ITS DISTRIBUTION AND MINERALOGY AN - 19050900; 7210148 AB - SUSPENDED PARTICULATE MATTER DISTRIBUTION IN MONTEREY BAY, CALIFORNIA, WAS CHARACTERIZED BY THE RATIO OF LIGHT SCATTERING AT 45 DEG TO THAT AT 135 DEG, BY PARTICLE VOLUME DISTRIBUTIONS, AND CONSTITUENT DISTRIBUTIONS. DISTRIBUTIONS VARIED WITH TIME AND LOCATION. HIGH SCATTERING RATIOS AND HIGH VOLUME DISTRIBUTIONS WERE FOUND IN THE SAME VICINITY BUT THERE APPEARED TO BE A LACK OF CORRELATION BETWEEN THEIR ABSOLUTE VALUES. DEPTH HAD A DEFINITE INFLUENCE ON SCATTERING RATIOS. THE MINERALS, DETECTED BY X-RAY METHODS, IN THE WATER COLUMN AT THE PAJARO AND THE SALMIAS RIVER MOUTHS DID NOT FORM SEPARATE AND DISTINCT REGIONS. JADEITE WAS FOUND TO PREDOMINATE IN THE PAJARO RIVER AREA. (ENSIGN-PAI) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-734 869, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. M SC THESIS, SEPTEMBER 1971. 78 P, 39 FIG, 2 TAB, 11 REF, APPEND. AU - KAZANOWSKA, M AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/09// PY - 1971 DA - Sep 1971 KW - Water Resources Abstracts KW - *SUSPENDED LOAD KW - *PARTICLE SIZE KW - *DISTRIBUTION KW - *MINERALOGY KW - X-RAY ANALYSIS KW - DEPTH KW - RIVERS KW - RUNOFF KW - *MONTEREY BAY(CALIF) KW - LIGHT SCATTERING KW - SCATTERING RATIOS KW - SW 3020:Sources and fate of pollution KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19050900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SUSPENDED+MATTER+IN+MONTEREY+BAY%2C+CALIFORNIA%3A+SOME+ASPECTS+OF+ITS+DISTRIBUTION+AND+MINERALOGY&rft.au=KAZANOWSKA%2C+M&rft.aulast=KAZANOWSKA&rft.aufirst=M&rft.date=1971-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - MEASUREMENT OF THE GROWTH RATES OF MYTILUS CALIFORNIANUS AND MYTILUS EDULIS IN MONTEREY HARBOR AN - 19038729; 7210160 AB - GROWTH RATE MEASUREMENTS WERE MADE ON THE MYTILUS CALIFORNIANUS AND MYTILUS EDULIS SPECIES OF THE SEA MUSSEL IN MONTEREY HARBOR FROM AUGUST 1970 - AUGUST 1971. PLEXIGLASS-STAINLESS STEEL CAGES WERE USED EXPOSING THE MUSSEL POPULATIONS TO INTERTIDAL AND SUBTIDAL CONDITIONS. MAXIMUM LENGTH AND AVERAGE VOLUME MEASUREMENTS WERE TAKEN AT MONTHLY INTERVALS. BOTH MUSSEL SPECIES SHOWED A CLOSE CORRELATION BETWEEN SEA SURFACE TEMPERATURE AND GROWTH RATE WITH CHARACTERISTIC GROWTH PATTERNS FOR EACH SPECIES. GROWTH RATES VARIED AS TO AGES AND SIZES OF EACH SPECIES AS WELL AS VARYING MONTHLY, SEASONALLY AND ANNUALLY. (ENSIGN-PAI) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-734 982, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. M. SC THESIS, SEPTEMBER 1971. 102 P, 8 FIG, 1 TAB, 9 REF, 1 APPEND. AU - Delgado, R E AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/09// PY - 1971 DA - Sep 1971 KW - Water Resources Abstracts KW - *MUSSELS KW - *GROWTH RATES KW - *LENGTH KW - *VOLUME KW - *TEMPERATURE KW - SIZE KW - AGE KW - SEASONAL KW - MONTHLY KW - ANNUAL KW - *MONTEREY HARBOR KW - *SEA SURFACE TEMPERATURE KW - SW 4070:Ecological impact of water development KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19038729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=MEASUREMENT+OF+THE+GROWTH+RATES+OF+MYTILUS+CALIFORNIANUS+AND+MYTILUS+EDULIS+IN+MONTEREY+HARBOR&rft.au=Delgado%2C+R+E&rft.aulast=Delgado&rft.aufirst=R&rft.date=1971-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THERMAL CONDITIONS IN MONTEREY BAY DURING SEPTEMBER 1966 THROUGH SEPTEMBER 1967 AND JANUARY 1970 THROUGH JUNE 1971 AN - 19038702; 7210153 AB - THERMAL STUDIES WERE CONDUCTED IN MONTEREY BAY FROM SEPTEMBER 1966 TO SEPTEMBER 1967 AND FROM JANUARY 1970 TO JUNE 1971. COMPARISONS OF OBSERVATIONS TAKEN AT APPROXIMATELY WEEKLY INTERVALS TO THE LONG-TERM AVERAGES DEVELOPED BY LAMMERS (40 YEARS) WERE MADE. TEMPERATURE DATA OUT TO 80 MILES IN THE BAY WERE TAKEN IN AUGUST 1970 AND COMPARED TO OBSERVED THERMAL CONDITIONS DURING FOUR QUASI-SYNOPTIC PERIODS IN AUGUST. THE NORMS PROVIDED AN EXCELLENT BASIS TO WHICH DIRECT TEMPERATURE OBSERVATIONS DURING QUASI-SYNOPTIC PERIODS COULD BE COMPARED. COMPARISONS OF THERMAL INDICES (DEPTH OF 9 DEG C ISOTHERM, TEMPERATURE AT 20 METERS, AND SEA SURFACE TEMPERATURE AT VARIOUS LOCATIONS) PROVED VALUABLE PARAMETERS IN IDENTIFYING THE THREE CLIMATIC SEASONS OF UPWELLING, OCEANIC AND DAVIDSON CURRENT AS WELL AS THE EXISTENCE OF ANOMALOUS THERMAL CONDITIONS. (ENSIGN-PAI) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-733 238, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. M SC THESIS, SEPTEMBER 1971. 78 P, 37 FIG, 2 TAB, 17 REF, 1 APPEND. AU - Anderson, R C AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/09// PY - 1971 DA - Sep 1971 KW - Water Resources Abstracts KW - *CALIFORNIA KW - *THERMAL WATER KW - *DATA COLLECTIONS KW - *ISOTHERMS KW - *TEMPERATURE KW - *MONTEREY BAY KW - THERMAL CONDITIONS KW - WEEKLY DATA KW - QUASI-SYNOPTIC PERIODS KW - UPWELLING KW - DAVIDSON CURRENT KW - OCEANIC PERIOD KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19038702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THERMAL+CONDITIONS+IN+MONTEREY+BAY+DURING+SEPTEMBER+1966+THROUGH+SEPTEMBER+1967+AND+JANUARY+1970+THROUGH+JUNE+1971&rft.au=Anderson%2C+R+C&rft.aulast=Anderson&rft.aufirst=R&rft.date=1971-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A STUDY OF LIGHT ATTENUATION IN MONTEREY BAY, CALIFORNIA AN - 19032804; 7213798 AB - A SINGLE OCEAN STATION WAS OCCUPIED (USING AN OCEANOGRAPHIC VESSEL) FOR 27 HOURS DURING THE UPWELLING PERIOD IN MONTEREY BAY, CALIFORNIA IN ORDER TO FIND THE QUALITATIVE RELATIONS BETWEEN ALPHA AND TEMPERATURE, SALINITY, DENSITY, OXYGEN AND PHOSPHATE CONCENTRATIONS, AND PARTICULATE MATTER AT A SINGLE SITE OVER AN EXTENDED PERIOD OF TIME, AND TO MAKE COMPARISONS WITH PREVIOUS LOCAL STUDIES. A MARINE ADVISORS' MODEL C-2 BEAM TRANSMISSOMETER (ALPHA METER) WHICH COMPARES FAVORABLY WITH A SCRIPPS FOLDED PATH TRANSMISSOMETER WAS USED TO STUDY LIGHT ATTENUATION. OTHER INSTRUMENTS INCLUDED A BISSETT-BERMAN TELEMETERING SALINITY-TEMPERATURE-DEPTH-SOUND VELOCITY SYSTEM MODEL 9040 WHICH CAN BE SET IN VARIOUS MODES OF OPERATION DEPENDING ON THE ENVIRONMENTAL CONDITIONS MEASURED; A SIPPICAN EXPENDABLE BATHYTHERMOGRAPH SYSTEM WITH AN ACCURACY OF PLUS OR NIMUS 0.2 DEGREE C AND PLUS OR MINUS 2 PERCENT OR 15 FEET, WHICHEVER IS GREATER; AND A MODEL T 15-CHANNEL COULTER COUNTER FOR PARTICULATE MATTER ANALYSIS. A TOTAL OF 48 CASTS WERE MADE DURING THE 27-HR PERIOD WITH ALL MEASUREMENTS BEING TAKEN AT THE SAME DEPTHS. IT WAS FOUND THAT THE VERTICAL DISTRIBUTIONS OF THE OCEANOGRAPHIC PARAMETERS STUDIED ARE DEPENDENT ON BOTH THE SEASONAL CONDITIONS AND GEOGRAPHICAL LOCATION. THE LARGEST CONCENTRATION OF SUSPENDED PARTICLES WAS FOUND IN THE UPPER 10-15 M OF THE WATER COLUMN WHERE MOST OF THE LIGHT ATTENUATION OCCURRED. THE LARGEST ATTENUATION GRADIENT WAS FOUND IN THE PYCNOCLINE. A LINEAR RELATION WAS SUGGESTED BETWEEN THE ATTENUATION COEFFICIENT AND THE CUMULATIVE PROJECTED CROSS-SECTIONAL AREA OF THE PARTICLES. (LONG-BATTELLE) JF - MASTER'S THESIS, SEPTEMBER 1971. 149 P, 52 FIG, 10 TAB, 26 REF. AU - Crews, T W AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/09// PY - 1971 DA - Sep 1971 KW - Water Resources Abstracts KW - *SEA WATER KW - *INSTRUMENTATION KW - *ON-SITE TESTS KW - *PHYSICAL PROPERTIES KW - *CHEMICAL PROPERTIES KW - *CALIFORNIA KW - ATTENUATION KW - LIGHT KW - OXYGEN KW - PHOSPHATES KW - SEDIMENTS KW - SUSPENDED SOLIDS KW - SALINITY KW - DENSITY KW - METHODOLOGY KW - SAMPLING KW - ABSORPTION KW - OCEANS KW - UPWELLING KW - PHOSPHORUS KW - WATER TEMPERATURE KW - TELEMETRY KW - OPTICAL PROPERTIES KW - OCEANOGRAPHY KW - *MONTEREY BAY(CALIF) KW - BEAM TRANSMISSION KW - COULTER COUNTER KW - LASERS KW - PARTICULATE MATTER KW - PYCNOCLINE KW - SW 3010:Identification of pollutants KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19032804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+STUDY+OF+LIGHT+ATTENUATION+IN+MONTEREY+BAY%2C+CALIFORNIA&rft.au=Crews%2C+T+W&rft.aulast=Crews&rft.aufirst=T&rft.date=1971-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - PENETRATION OF FREE-FALLING OBJECTS INTO DEEP-SEA SEDIMENTS AN - 19272177; 7304195 AB - A METHOD IS PRESENTED TO PREDICT THE PENETRATION OF FREE-FALLING OBJECTS INTO DEEP-SEA SEDIMENTS BY COMBINING PROVEN EMPIRICAL THEORIES FROM THE FIELD OF SOIL MECHANICS WITH KNOWN HYDRODYNAMIC PHENOMENA. THE IMPACT VELOCITY OF THE OBJECT AND THE SHEAR STRENGTH PROFILE AND DENSITY OF THE SEDIMENT ARE ASSUMED TO BE KNOWN. PENETRATION IS CALCULATED USING A COMPUTER, BY EQUATING THE WORK DONE DURING PENETRATION TO THE ENERGY OF THE OBJECT FALLING ONTO A MODELED DEEP-SEA SEDIMENT. THE OBJECTS WERE SIMPLE GEOMETRIC SHAPES RANGING IN WEIGHT FROM 500 TO MORE THAN 1,000 POUNDS. THE IMPACT VELOCITIES RANGED FROM 0 TO 20 FEET PER SECOND. THE METHOD SUCCESSFULLY PREDICTS THE PENETRATION OF OBJECTS INTO WEAK, SATURATED, SEDIMENTS WITHIN THE ACCURACY OF THE STATE-OF-THE-ART TECHNIQUES FOR MEASURING THE MECHANICAL PROPERTIES OF SEDIMENTS. THE IMPACT DURATION TIME WAS RELATIVELY CONSTANT AND INDEPENDENT OF OBJECT VELOCITY, SHAPE, AND WEIGHT; THIS IMPLIES THAT IT MAY BE A UNIQUE PROPERTY OF THE DYNAMIC BEHAVIOR OF A SEDIMENT TYPE. (KNAPP-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA 22151, AS AD-741 140; PRICE $3.00 PAPER COPY; $0.95 MICROFICHE. M SC THESIS, DECEMBER 1971. 263 P, 14 FIG, 10 TAB, 83 REF. AU - CARLMARK, J W AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/04// PY - 1971 DA - Apr 1971 KW - Water Resources Abstracts KW - *BOTTOM SEDIMENTS KW - *BEARING STRENGTH KW - *COMPRESSIBILITY KW - *PENETRATION KW - SEDIMENT-WATER INTERFACES KW - SEDIMENTOLOGY KW - OCEANOGRAPHY KW - PHYSICAL PROPERTIES KW - HYDRODYNAMICS KW - MATHEMATICAL MODELS KW - COMPUTER PROGRAMS KW - SETTLING VELOCITY KW - SW 5080:Evaluation, processing and publication KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19272177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=PENETRATION+OF+FREE-FALLING+OBJECTS+INTO+DEEP-SEA+SEDIMENTS&rft.au=CARLMARK%2C+J+W&rft.aulast=CARLMARK&rft.aufirst=J&rft.date=1971-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - RECENT MARINE SEDIMENTS OF CARMEL BAY, CALIFORNIA AN - 19069721; 7305796 AB - FIFTY-SIX SEDIMENT SAMPLES WERE COLLECTED WITHIN CARMEL BAY, CALIFORNIA, FOR TEXTURAL ANALYSIS. THE SEDIMENTS WITHIN THE CARMEL SUBMARINE CANYON CONSIST, FOR THE MOST PART, OF POORLY TO VERY POORLY SORTED VERY FINE SAND AND COARSE SILT. THE SHELF AREA SURROUNDING THE CANYON IS PRIMARILY COMPRISED OF MODERATELY TO VERY POORLY SORTED SAND, WITH A SMALL AREA OF VERY POORLY SORTED GRAVEL IN THE NORTHEASTERN SECTION OF THE BAY. CONSIDERATION OF TEXTURAL PARAMETERS SUCH AS MEAN SIZE, STANDARD DEVIATION, AND SKEWNESS SUGGESTS THAT THE SEDIMENTS ARE UNDER THE INFLUENCE OF DYNAMIC SEDIMENT TRANSPORT. THE BAY APPEARS TO BE A SEDIMENTARY SYSTEM PRIMARILY ISOLATED FROM ADJACENT COASTAL SEDIMENT SOURCES, WITH THE MAJOR SOURCES OF SEDIMENTARY DEPOSITS BEING TERRIGENOUS DEBRIS FROM THE CARMEL RIVER, EROSION AND WEATHERING OF THE LOCAL COASTLINE AND OFFSHORE ROCKS BY WAVE AND WEATHER, AND THE SHELLS AND TESTS OF NUMEROUS CALCAREOUS MARINE ORGANISMS. MOVEMENT OF SEDIMENTS BY SLUMPING AND GRAVITY SLIDING DOWN THE CARMEL SUBMARINE CANYON APPEARS TO BE THE ONLY FORM OF SEDIMENT REMOVAL WITHIN THE BAY. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA., 22151 AS AD-741 122, PRICE $3.00 PRINTED COPY; $0.95 MICROFICHE. M SC THESIS, DECEMBER, 1971. 57 P, 9 FIG, 2 TAB, 21 REF. AU - Carter, L S AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/04// PY - 1971 DA - Apr 1971 KW - Water Resources Abstracts KW - *SEDIMENTOLOGY KW - *PARTICLE SIZE KW - *SEDIMENT TRANSPORT KW - *BAYS KW - *CALIFORNIA KW - SEDIMENTS KW - BOTTOM SEDIMENTS KW - SEDIMENTATION KW - SANDS KW - SILTS KW - GRAVELS KW - PHYSICAL PROPERTIES KW - EROSION KW - SAMPLING KW - DATA COLLECTIONS KW - *CARMEL BAY(CALIF) KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19069721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=RECENT+MARINE+SEDIMENTS+OF+CARMEL+BAY%2C+CALIFORNIA&rft.au=Carter%2C+L+S&rft.aulast=Carter&rft.aufirst=L&rft.date=1971-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - STUDY OF THE NEAR SHORE SURFACE CHARACTERISTICS OF WINDROWS AND LANGMUIR CIRCULATION IN MONTEREY BAY AN - 19032968; 7206487 AB - OBSERVATIONS OF THE SPACING AND ANGLE OF WINDROWS (WIND-BLOWN PATTERNS ON SURFACE WATERS) WITH RESPECT TO THE WIND SPEED AND DIRECTION WERE CONDUCTED IN MONTEREY BAY, CALIFORNIA, USING AERIAL PHOTOGRAPHS TAKEN OF WINDROW ACCUMULATIONS ON APRIL 13, 20, AND 27, AND MAY 3 AND 11, 1971. THE SPACING OF WINDROWS WAS FOUND TO DEPEND UPON WIND SPEED. THESE WINDROWS ARE INDICATIVE OF THE PRESENCE OF HELICAL VORTICES IN THE SURFACE WATERS, AND THE DATA SUPPORT LANGMUIR'S CONTENTION THAT THE VORTICES ARE WIND DRIVEN. DEFLECTION ANGLES SHOWED SMALL VARIATIONS TO THE LEFT AND RIGHT OF THE WIND DIRECTION. NO CORRELATION WAS FOUND BETWEEN DEPTH OF THE THERMOCLINE AND ROW SPACING. THE LANGMUIR CIRCULATION INVESTIGATED IN MONTEREY BAY SHOWED A CELLULAR PATTERN WITH VERTICAL VELOCITIES OF 2.2 CM/SEC DOWNWARD IN THE AREA OF CONVERGENCE AND 0.8 CM/SEC UPWARD IN THE AREA OF DIVERGENCE, AT A WIND SPEED OF 6.0 M/SEC. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA. 22151 AS AD-733 197 - PRICE $3.00. M SC THESIS, SEPTEMBER 1971. 72 P, 23 FIG, 9 REF, 3 APPEND. AU - Maratos, A AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF. DEPT. OF OCEANOGRAPHY Y1 - 1971/04// PY - 1971 DA - Apr 1971 KW - Water Resources Abstracts KW - *WATER CIRCULATION KW - *SURFACE WATERS KW - *BAYS KW - *WINDS KW - *MOVEMENT KW - DATA COLLECTIONS KW - ANALYTICAL TECHNIQUES KW - AERIAL PHOTOGRAPHY KW - WATER TEMPERATURE KW - THERMOCLINE KW - VORTICES KW - VELOCITY KW - DEFLECTION KW - *MONTEREY BAY(CALIF) KW - SW 0835:Streamflow and runoff KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19032968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=STUDY+OF+THE+NEAR+SHORE+SURFACE+CHARACTERISTICS+OF+WINDROWS+AND+LANGMUIR+CIRCULATION+IN+MONTEREY+BAY&rft.au=Maratos%2C+A&rft.aulast=Maratos&rft.aufirst=A&rft.date=1971-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SYSTEMS ANALYSIS OF METHODS FOR MEASURING TRACE DISSOLVED ORGANIC MATTER IN SEAWATER AN - 19031482; 7204382 AB - THREE METHODS ARE DESCRIBED FOR MEASURING DISSOLVED ORGANIC COMPOUNDS IN SEAWATER. THESE METHODS INCLUDE QUANTITATIVE GAS CHROMATOGRAPHIC ANALYSIS OF ALL AMINO ACIDS AND QUALITATIVE RESULTS FOR HISTIDINE, CYSTINE, TRYPTOPHAN, AND ARGININE; GAS CHROMATOGRAPHIC ANALYSIS OF LIPIDS INCLUDING LIGHT HYDROCARBONS, FATTY ACIDS, AND STEROLS; AND AUTOANALYSIS WITH ETRAZOLEUM BLUE AFTER CHARCOAL ADSORPTION FOR SOLUBLE SUGAR COMPOUNDS LIKE GLUCOSE, SUCROSE, AND FRUCTOSE. SYNOPTIC DATA OF THESE COMPOUNDS ARE COMPARED WITH TOTAL ORGANIC CARBON. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA. 22151, AS AD-728 665, $3.00 IN PAPER COPY. M. SC. THESIS, NAVAL POSTGRADUATE SCHOOL, JUNE 1971. 97 P, 3 FIG, 7 TAB, 173 REF. AU - Diehl, G F AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/04// PY - 1971 DA - Apr 1971 KW - Water Resources Abstracts KW - *CHEMICAL ANALYSIS KW - *ORGANIC COMPOUNDS KW - *SEA WATER KW - *ANALYTICAL TECHNIQUES KW - *GAS CHROMATOGRAPHY KW - AMINO ACIDS KW - LIPIDS KW - CARBOHYDRATES KW - WATER CHEMISTRY KW - SALINITY KW - OCEANS KW - POLLUTANT IDENTIFICATION KW - AUTOANALYSIS KW - TOTAL ORGANIC CARBON KW - SW 0880:Chemical processes KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19031482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SYSTEMS+ANALYSIS+OF+METHODS+FOR+MEASURING+TRACE+DISSOLVED+ORGANIC+MATTER+IN+SEAWATER&rft.au=Diehl%2C+G+F&rft.aulast=Diehl&rft.aufirst=G&rft.date=1971-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - BEACH CUSPS OF MONTEREY BAY, CALIFORNIA AN - 19019450; 7206485 AB - A RADIOGRAPHIC STUDY WAS CONDUCTED ON IMPREGNATED SAND SAMPLES TAKEN FROM BEACH CUSPS ON MARINA BEACH, MONTEREY BAY, CALIFORNIA FROM SEPTEMBER 1970 TO APRIL 1971. THE MICROSTRUCTURE CONSISTED OF CROSS-LAMINATION, RHYTHMIC STRATIFICATION, AND DISTINCT MINERAL LAYERING. MIGRATION OF THESE CUSPS WAS STUDIED BY MEANS OF VISUAL OBSERVATIONS AND TIME-LAPSE PHOTOGRAPHY. CYCLIC CHANGES IN THE CUSP PROFILE WERE FOUND TO CORRESPOND WITH WAVE ACTION AND TIDAL INFLUENCES. NO SIMPLE RELATION BETWEEN OCEAN ACTION AND CUSP STRUCTURE OR DEVELOPMENT WAS EVIDENT. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA. 22151 AS AD-733 176, PRICE $3.00 PAPER COPY; $0.95 MICROFICHE. M SC THESIS, JUNE 1971. 159 P, 94 FIG, 1 TAB, 43 REF. AU - Brueggeman, J L AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF. DEPT. OF OCEANOGRAPHY Y1 - 1971/04// PY - 1971 DA - Apr 1971 KW - Water Resources Abstracts KW - *BEACHES KW - *DEPOSITION(SEDIMENTS) KW - *TIDAL EFFECTS KW - *BAYS KW - *CALIFORNIA KW - SANDS KW - WAVES(WATER) KW - EROSION KW - GEOMORPHOLOGY KW - ANALYTICAL TECHNIQUES KW - PHOTOGRAPHY KW - SAMPLING KW - DATA COLLECTIONS KW - LITTORAL DRIFT KW - *MONTEREY BAY(CALIF) KW - *MARINA BEACH(CALIF) KW - RADIOGRAPHIC STUDY KW - CUSPS KW - SPITS KW - SW 0870:Erosion and sedimentation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19019450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=BEACH+CUSPS+OF+MONTEREY+BAY%2C+CALIFORNIA&rft.au=Brueggeman%2C+J+L&rft.aulast=Brueggeman&rft.aufirst=J&rft.date=1971-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - AMENITIES RIGHTS--PARALLELS TO POLLUTION TAXES AN - 19016443; 7200192 AB - THIS ARTICLE CONSIDERS POLLUTION TAXES AND AMENITIES RIGHTS AS POSSIBLE SOLUTIONS TO THE PROBLEMS OF ENVIRONMENTAL POLLUTION. SPECIAL ATTENTION IS GIVEN TO MICHIGAN'S RECENTLY ENACTED THOMAS S. ANDERSON, GORDON ROCKWELL ENVIRONMENTAL PROTECTION ACT. THIS ACT IS CONSIDERED TO BE AN EXCELLENT METHOD OF PROVIDING THE INDIVIDUAL WITH THE POWER TO TAKE LEGAL ACTION AGAINST POLLUTERS. THE ADVANTAGES OF INDIVIDUAL AMENITIES RIGHTS IN FIGHTING POLLUTION ARE CONSIDERED TO BE THREEFOLD. FIRST, DECENTRALIZATION WOULD BE ACCOMPLISHED SINCE THE ENFORCEMENT OF THE OBLIGATION NOT TO POLLUTE THE ENVIRONMENT WOULD BE PERFORMED BY INDIVIDUALS WHO ARE MOST DIRECTLY HARMED. SECONDLY, POLLUTION COSTS WOULD BECOME PART OF THE COSTS OF PRODUCTION THROUGH INSURANCE EXPENSES INCURRED TO PROTECT THE FIRM FROM INDIVIDUAL LAWSUIT LIABILITY. FINALLY, THE GROWTH OF INTERNATIONAL OPERATIONS CAN BE ACHIEVED IF JUDGMENTS AGAINST POLLUTERS ARE GIVEN TRANSNATIONAL RECOGNITION BY TREATY OR EXTENSION OF THE RULES CONCERNING CONFLICTS OF LAW. THE ROLE WHICH THE GOVERNMENT MUST PLAY IN THE CREATION OF SUCH AMENITIES RIGHTS IS CONSIDERED, ALONG WITH THE PREVENTION OF POSSIBLE ABUSES BY INDIVIDUALS. THE ARTICLE CONCLUDES WITH A CONSIDERATION OF THE EFFECT OF AMENITIES RIGHTS ON THE INTERNATIONAL SCENE. (HORWITZ-FLORIDA) JF - NATURAL RESOURCES JOURNAL, VOL 11, NO 2, P 274-280, APRIL 1971. 7 P, 17 REF. AU - GOLDIE, LFE AD - NAVAL WAR COLLEGE, NEWPORT, R. I Y1 - 1971/04// PY - 1971 DA - Apr 1971 KW - Water Resources Abstracts KW - *POLLUTION ABATEMENT KW - *PUBLIC RIGHTS KW - *JUDICIAL DECISIONS KW - *TAXES KW - LEGAL ASPECTS KW - POLITICAL ASPECTS KW - INTERNATIONAL LAW KW - STATE GOVERNMENTS KW - STATE JURISDICTION KW - FEDERAL GOVERNMENT KW - WATER POLLUTION KW - LEGISLATION KW - PERMITS KW - PROJECT PLANNING KW - THIRD PARTY EFFECTS KW - INDUSTRIAL WASTES KW - WATER POLLUTION CONTROL KW - ENVIRONMENT KW - ENVIRONMENTAL EFFECTS KW - SW 4030:Cost allocation, cost sharing, pricing KW - SW 3070:Water quality control KW - SW 4050:Water law and institutions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19016443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=AMENITIES+RIGHTS--PARALLELS+TO+POLLUTION+TAXES&rft.au=GOLDIE%2C+LFE&rft.aulast=GOLDIE&rft.aufirst=LFE&rft.date=1971-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SAND BUDGET FOR CAPITOLA BEACH, CALIFORNIA AN - 19064874; 7402718 AB - THE BEACH AT CAPITOLA, CALIFORNIA HAS A HISTORY OF SHORT-TERM VARIATIONS ABOUT A NOMINALLY WIDE BEACH. THIS PATTERN WAS INTERRUPTED IN 1965 WHEN THE BEACH WAS GREATLY DEPLETED FOLLOWING THE CONSTRUCTION OF SANTA CRUZ HARBOR. THE BEACH REMAINED SMALL UNTIL THE CONSTRUCTION OF A GROIN AND SUBSEQUENT SAND FILL AT CAPITOLA IN 1970. THE ANNUAL SAND BUDGET DEVELOPED FOR CAPITOLA IN 1970. THE ANNUAL SAND BUDGET DEVELOPED FOR CAPITOLA BEACH SHOWS A NET GAIN OF 1,300 CU. YDS. THE SAND SOURCES ARE LITTORAL DRIFT, 300,000 CU. YDS., RIVER DISCHARGE, 8,000 CU. YDS., AND SEACLIFF EROSION, 3,800 CU. YDS., WHILE SAND LOSS IS DUE TO LITTORAL DRIFT, 310,500 CU YDS. THE OBSERVED SHORT-TERM VARIATIONS IN THE BEACH ARE REFLECTED IN THE MONTHLY SAND BUDGET. THE BUDGET PERMITS EVALUATION OF THE EFFECT ON THE BEACH OF VARYING EACH SOURCE DUE TO THE CONSTRUCTION OF ARTIFICIAL BARRIERS. IT IS CONCLUDED THAT THE HARBOR CONSTRUCTION AT SANTA CRUZ WAS RESPONSIBLE FOR THE SAND DEPLETION AT CAPITOLA BEACH IN 1965. (SINHA - OEIS) JF - MSC THESIS, MARCH 1971. 59 P, 7 FIG, 6 TAB, 11 REF, 4 APPEND. AVAILABLE FROM NTIS AS AD-728 724, $3.00 IN PAPER COPY. AU - Anderson, R G AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1971/03// PY - 1971 DA - Mar 1971 KW - Water Resources Abstracts KW - *CALIFORNIA KW - *BEACH EROSION KW - *COASTAL STRUCTURES KW - *BARRIERS KW - HARBORS KW - SEASONAL KW - GROINS(STRUCTURES) KW - CAPITOLA BEACH(CALIF) KW - SAND BUDGET KW - SW 6020:Hydraulics KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19064874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SAND+BUDGET+FOR+CAPITOLA+BEACH%2C+CALIFORNIA&rft.au=Anderson%2C+R+G&rft.aulast=Anderson&rft.aufirst=R&rft.date=1971-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THE EFFECT OF VARYING THE PARAMETERS OF VANE SHEAR TESTS OF MARINE SEDIMENTS AN - 19012393; 7110899 AB - THE CONSEQUENCES RESULTING FROM VARYING THE PARAMETERS OF THE VANE SHEAR TEST (USED TO DETERMINE THE SHEAR STRENGTH OF MARINE SEDIMENTS) WERE INVESTIGATED. EXPERIMENTS SHOWED THAT LARGER RATIOS OF CONTAINER DIAMETER TO VANE DIAMETER YIELD MORE ACCURATE SHEAR STRENGTHS. IT WAS ALSO SHOWN THAT THE FOUR-BLADED VANE PRODUCED THE BEST RESULTS. FINALLY, RATES OF ROTATION OF ONE AND TWO REVOLUTIONS PER HOUR WERE FOUND TO GIVE ACCURATE VALUES OF SHEAR STRENGTH, WHILE HIGHER RATES OF ROTATION PROVED TO BE UNSATISFACTORY. JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD 722 568, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. THESIS, MS, MARCH 1971, U.S. NAVAL POSTGRADUATE SCHOOL, 73 P. AU - Charles Singler, James AD - NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIF Y1 - 1971/03// PY - 1971 DA - Mar 1971 KW - Water Resources Abstracts KW - *BEDS KW - *SOIL MECHANICS KW - *SEDIMENTATION KW - *SHEAR STRESS KW - SEDIMENTS KW - TEST PROCEDURES KW - *OCEAN BOTTOM KW - FLEXURAL STRENGTH KW - OCEAN BOTTOM SAMPLING KW - TEST EQUIPMENT KW - VANE SHEAR TESTS KW - SW 5040:Data acquisition KW - SW 6040:Soil mechanics KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19012393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THE+EFFECT+OF+VARYING+THE+PARAMETERS+OF+VANE+SHEAR+TESTS+OF+MARINE+SEDIMENTS&rft.au=Charles+Singler%2C+James&rft.aulast=Charles+Singler&rft.aufirst=James&rft.date=1971-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - DIRECT SHEAR TESTING OF MARINE SEDIMENT AN - 19007782; 7110900 AB - TRADITIONALLY, THE METHODS USED TO DETERMINE THE MECHANICAL PROPERTIES OF MARINE SEDIMENTS WERE THOSE USED IN THE FIELD OF SOIL MECHANICS. THESE METHODS ARE GENERALLY ACCEPTABLE WHEN THE SEDIMENT TESTED IS PLASTIC OR AT WATER CONTENTS BELOW THE LIQUID LIMIT. HOWEVER, FOR PREDICTING IN-SITU CONDITIONS, THAT IS FOR SEDIMENT AT WATER CONTENTS ABOVE THE LIQUID LIMIT, THE PROBLEM IS COMPLEX. SPECIFICALLY, THE DETERMINATION OF SHEAR STRENGTH OF AN UNCONSOLIDATED-UNDRAINED SAMPLE BY THE DIRECT SHEAR METHOD WAS FOUND TO EXHIBIT AN ANGLE OF INTERNAL FRICTION RANGING FROM 19 DEGREES TO 23.5 DEGREES. THIS INDICATES THAT THE SHEAR STRENGTH OF THE SEDIMENTS IS DEPENDENT ON THE NORMAL LOAD APPLIED TO IT. JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-722 567, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. THESIS, MS, MARCH 1971, U.S. NAVAL POSTGRADUATE SCHOOL. 76 P. AU - Stoddard Berg, John AD - NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIF Y1 - 1971/03// PY - 1971 DA - Mar 1971 KW - Water Resources Abstracts KW - *BEDS KW - *SOIL MECHANICS KW - *SEDIMENTATION KW - *SHEAR STRESS KW - SEDIMENTS KW - TEST PROCEDURES KW - *OCEAN BOTTOM KW - FLEXURAL STRENGTH KW - OCEAN BOTTOM SAMPLING KW - TEST EQUIPMENT KW - SW 5040:Data acquisition KW - SW 6040:Soil mechanics KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19007782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=DIRECT+SHEAR+TESTING+OF+MARINE+SEDIMENT&rft.au=Stoddard+Berg%2C+John&rft.aulast=Stoddard+Berg&rft.aufirst=John&rft.date=1971-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - WATER CONTENT DETERMINATIONS FOR DRIED MARINE SEDIMENTS AN - 19007312; 7110669 AB - A QUANTITATIVE ANALYSIS OF RESIDUAL SALTS IN DRIED MARINE SEDIMENTS WAS ACCOMPLISHED BY RECONSTITUTING THE SEDIMENT WITH DISTILLED WATER AND MEASURING THE SALINITY OF THE RESULTING SOLUTION. THE INFORMATION OBTAINED FROM THESE MEASUREMENTS PROVIDED AN EXCELLENT BASIS FOR PREDICTING THE WATER CONTENT OF THE ORIGINAL UNALTERED SAMPLES. WITH THE ORIGINAL SALINITY OF THE INTERSTITIAL WATER KNOWN THE WATER CONTENTS COMPUTED FROM THE SALT CONTENT DETERMINATIONS WERE, FOR ALL PRACTICAL PURPOSES, AS ACCURATE AS THE ORIGINAL WATER CONTENTS. JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-722 594, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MS, THESIS, NAVAL POSTGRADUATE SCHOOL, MARCH 1971, 64 P. AU - Christian Peterson, John AD - NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIF Y1 - 1971/03// PY - 1971 DA - Mar 1971 KW - Water Resources Abstracts KW - *BEDS KW - *SEDIMENTATION KW - *SEA WATER KW - *SALINITY KW - *OCEAN BOTTOM SAMPLING KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19007312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=WATER+CONTENT+DETERMINATIONS+FOR+DRIED+MARINE+SEDIMENTS&rft.au=Christian+Peterson%2C+John&rft.aulast=Christian+Peterson&rft.aufirst=John&rft.date=1971-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A COMPARISON OF TWO METHODS FOR MEASURING RIGIDITY OF SATURATED MARINE SEDIMENTS AN - 19027783; 7110668 AB - THE RESULTS OF TWO DIFFERENT METHODS FOR DETERMINING THE RIGIDITY MODULUS OF A SOFT SEDIMENT ARE COMPARED. IN ONE METHOD THE RESONANT CHARACTERISTICS OF A TORSIONALLY OSCILLATING ROD WHICH ARE SENSITIVE TO THE SHEAR ACOUSTIC IMPEDANCE OF SEDIMENT IN WHICH THE ROD IS IMBEDDED DETERMINE THE COMPLEX RIGIDITY. THE SECOND METHOD UTILIZES THE OBSERVATION OF THE PHASE VELOCITY OF AN INTERFACE WAVE AT THE WATER-SEDIMENT BOUNDARY. SHEAR WAVE SPEEDS COMPUTED FROM THE EXPERIMENTAL DATA FROM BOTH METHODS ARE QUITE SIMILAR IN MAGNITUDE. FOR THE SEDIMENT USED HERE, THE AVERAGE VALUE OF SHEAR WAVE SPEED DETERMINED FROM THE INTERFACE WAVE EXPERIMENT WAS 33 M/SEC WHILE THE SHEAR WAVE SPEED DETERMINED FROM THE MEASURED RIGIDITY WAS 29 M/SEC. THE DIFFERENCE LIES WITHIN EXPERIMENTAL UNCERTAINTY. TRENDS IN THE MASS-PHYSICAL PROPERTIES OF THE SEDIMENTS ARE INVESTIGATED BY COMPARING GRAPHICALLY THE DEPENDENCE OF BOTH THE REAL AND IMAGINARY PARTS OF THE COMPLEX RIGIDITY ON DENSITY, POROSITY, SOUND SPEED, SILT AND CLAY PERCENTAGES, POISSON'S RATIO AND DENSITY TIMES SOUND SPEED SQUARED. JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-722 580, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MS, THESIS, NAVAL POSTGRADUATE SCHOOL DECEMBER 1970, 65 P. AU - Bryan Lasswell, James AD - NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIF Y1 - 1970/12// PY - 1970 DA - Dec 1970 KW - Water Resources Abstracts KW - *BEDS KW - *SOIL MECHANICS KW - *SHEAR STRESS KW - *SEDIMENTATION KW - SILT CLAY DENSITY KW - POROSITY KW - CORRELATION ANALYSIS KW - RIGIDITY KW - COHESIVE SOILS KW - *OCEAN BOTTOM KW - INTERFACES KW - SOUND TRANSMISSION KW - ECHO RANGING KW - SW 5040:Data acquisition KW - SW 6040:Soil mechanics KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19027783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+COMPARISON+OF+TWO+METHODS+FOR+MEASURING+RIGIDITY+OF+SATURATED+MARINE+SEDIMENTS&rft.au=Bryan+Lasswell%2C+James&rft.aulast=Bryan+Lasswell&rft.aufirst=James&rft.date=1970-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A NUMERICAL INVESTIGATION OF TIDAL CURRENT CIRCULATION IN THE GULF OF MAINE AN - 19006367; 7106801 AB - THE HYDRODYNAMICAL-NUMERICAL MODEL OF WALTER HANSEN IS USED TO COMPUTE TIDAL HEIGHTS AND TIDAL CURRENTS IN THE GULF OF MAINE. THE MODEL USES TWO ADJACENT OPEN BOUNDARIES AT WHICH THE TIDES ARE PRESCRIBED AT EACH TIME STEP, USING FOUR TIDAL CONSTITUENTS. THE GRID SIZE IS SIX NAUTICAL MILES AND THE TIME STEP IS THIRTY-ONE SECONDS. SEVEN DATA RUNS ARE REPORTED; ONE USES THE TIDES AND NO WIND AND THE REMAINING SIX USE UNIFORM WIND FIELDS IN CONSORT WITH THE TIDES. A MODIFIED METHOD OF HANDLING THE TOPOGRAPHIC DATA IS USED. THE PERTINENT RESULTS OF THE STUDY ARE: (1) THE USE OF HANSEN'S MODEL WITH ADJACENT OPEN BOUNDARIES PRODUCES BROAD SUBJECTIVE AGREEMENT WITH OBSERVED DATA, (2) THE MODIFIED METHOD OF HANDLING TOPOGRAPHIC INPUT DATA IS WORKABLE, (3) WIND DIRECTION AND VELOCITY PRODUCE SLIGHT VARIATIONS IN TIDAL HEIGHT, (4) WIND DIRECTION AND VELOCITY MODIFY THE DIRECTION OF THE TIDAL CURRENTS CONSIDERABLY AND PRODUCE SOME SIGNIFICANT INCREASES IN TIDAL CURRENT SPEED, AND (5) THE MODIFYING INFLUENCES OF WIND FIELDS ON TIDAL HEIGHTS, TIDAL CURRENT VELOCITIES, AND TIDAL CURRENT DIRECTIONS ARE MORE NOTICEABLE IN SHALLOW WATER AREAS THAN IN REGIONS OF DEEP WATER. JF - AVAILABLE FROM NTIS AS AD-714 612, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. THESIS, MS IN OCEANOGRAPHY, NAVAL POST GRADUATE SCHOOL, OCT 1970. 69 P. AU - PAUL DRENNA, ARTHUR AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1970/10// PY - 1970 DA - Oct 1970 KW - Water Resources Abstracts KW - *TIDES KW - *MATHEMATICAL MODELS KW - *OCEAN CURRENTS KW - *WIND TIDES KW - WAVES KW - *MAIN GULF KW - TIDAL HEIGHT KW - SW 5040:Data acquisition KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19006367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+NUMERICAL+INVESTIGATION+OF+TIDAL+CURRENT+CIRCULATION+IN+THE+GULF+OF+MAINE&rft.au=PAUL+DRENNA%2C+ARTHUR&rft.aulast=PAUL+DRENNA&rft.aufirst=ARTHUR&rft.date=1970-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - LONG WAVE STUDY OF MONTEREY BAY AN - 19079927; 7403615 AB - MONTEREY BAY, ON THE WEST COAST OF THE UNITED STATES, IS UNIQUE IN THAT IT IS A LARGE, SYMMETRIC, SEMI-ELLIPTICAL BAY DIVIDED NORTH AND SOUTH BY THE DEEP MONTEREY CANYON. THE EFFECT OF THE CANYON ON SEICHING WITHIN THE BAY AND ON LONG WAVE OSCILLATIONS WITHIN THE BAY WAS STUDIED BY ANALYZING SYNCHRONIZED WAVE RECORDS AT EACH END OF THE BAY. POWER SPECTRA AND CROSS SPECTRA CALCULATED FOR FIVE PERIODS SELECTED FROM SIX MONTHS CONTINUOUS DATA INDICATE THE MONTEREY CANYON HAS A PROFOUND EFFECT ON THE BAY'S OSCILLATING CHARACTERISTICS. THE CANYON APPEARS TO ACT AS AN IMPEDENCE BARRIER DIVIDING THE BAY INTO TWO INDEPENDENT OSCILLATING BASINS EACH HAVING RECURRING LONG-PERIOD WAVES WHICH PERSIST DURING SIGNIFICANT LONG-WAVE ACTIVITY. EXTENSIVE REFERENCE IS MADE TO THE WORK OF WILSON, HENDRICKSON AND KILMER (1965) IN THEIR FEASIBILITY STUDY FOR A SURGE-ACTION MODEL OF MONTEREY HARBOR, CALIFORNIA. (SINHA-OEIS) JF - AVAILABLE FROM NTIS AS AD-712 794, FOR $3.00 PAPER COPY, $1.45 MICROFICHE. M SC THESIS, SEPTEMBER 1970. 89 P, 29 FIG, 9 TAB, 7 REF, 3 APPEND. AU - Lynch, T J AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1970/09// PY - 1970 DA - Sep 1970 KW - Water Resources Abstracts KW - *BAYS KW - *SEICHES KW - *WAVES(WATER) KW - *COASTS KW - *CALIFORNIA KW - SUBMARINE CANYONS KW - MONTEREY BAY(CA) KW - OSCILLATIONS KW - *LONG WAVES KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19079927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=LONG+WAVE+STUDY+OF+MONTEREY+BAY&rft.au=Lynch%2C+T+J&rft.aulast=Lynch&rft.aufirst=T&rft.date=1970-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SWELL AND STORM CHARACTERISTICS FROM COASTAL WAVE RECORDS AN - 19025381; 7203080 AB - RECORDS FROM A WAVE SENSOR AT MONTEREY, CALIFORNIA YIELD A LINEAR FREQUENCY SHIFT ASSOCIATED WITH EACH ARRIVING SWELL TRAIN, FROM WHICH THE ORIGIN TIME AND TRAVEL DISTANCE OF THE SWELL CAN BE COMPUTED. SURFACE WEATHER MAPS CAN BE USED TO FIND THE SOURCE AND THE DEEP-WATER ARRIVAL DIRECTION OF THE SWELL. THE WAVE RECORDS ARE ANALYZED FOR THE FREQUENCY OF THE INDIVIDUAL WAVES COMPOSING WAVE GROUPS. FIVE OF THE SWELL SETS ORIGINATED IN NORTH PACIFIC STORMS ADVANCING TOWARD MONTEREY. THE SEAS IN THE FETCH WERE FULLY ARISEN AT THE TIME OF COMPUTED SWELL ORIGIN, AND THE SURFACE TO GEOSTROPHIC WIND RATIO WAS 0.83. THE DOMINANT SWELL EMERGED FROM THE FETCH AT A TIME WHEN ITS GROUP VELOCITY EQUALLED THE VELOCITY OF THE FETCH TOWARD MONTEREY. (SEE ALSO W72-03078) (KNAPP-USGS) JF - PROCEEDINGS OF THE TWELFTH COASTAL ENGINEERING CONFERENCE, SEPTEMBER 13-18, 1970, WASHINGTON, DC, VOLUME 1; AMERICAN SOCIETY OF CIVIL ENGINEERS, NEW YORK, NY, P 33-52, 1970. 7 FIG, 1 TAB, 7 REF. AU - Thompson, W C AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1970/09// PY - 1970 DA - Sep 1970 KW - Water Resources Abstracts KW - *OCEAN WAVES KW - *FREQUENCY ANALYSIS KW - *WINDS KW - DATA COLLECTIONS KW - CALIFORNIA KW - TIME SERIES ANALYSIS KW - ENERGY KW - DATA PROCESSING KW - STORMS KW - PACIFIC OCEAN KW - BEACH EROSION KW - COASTAL ENGINEERING KW - MONTEREY(CAL) KW - SW 6020:Hydraulics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19025381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SWELL+AND+STORM+CHARACTERISTICS+FROM+COASTAL+WAVE+RECORDS&rft.au=Thompson%2C+W+C&rft.aulast=Thompson&rft.aufirst=W&rft.date=1970-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - CALCULATED AND OBSERVED CHANGES IN SEA SURFACE TEMPERATURE ASSOCIATED WITH HURRICAN PASSAGE AN - 19021963; 7108347 AB - ANALYSES WERE MADE OF THE SEA SURFACE TEMPERATURES IN THE GULF OF MEXICO FOR THE MONTH OF AUGUST FOR THE FOUR YEARS 1965 THROUGH 1968. NO ONE PATTERN WAS FOUND TO PREDOMINATE. THE SUBSURFACE PROFILES WERE THEN CONSIDERED, AND A RATE OF SIMULATED WITHDRAWAL OF 4000 CALORIES OF HEAT PER DAY WAS MADE, UNTIL THE TEMPERATURE DID NOT EXCEED 26 DEG C. THIS WITHDRAWAL REPRESENTED HEAT REMOVED DURING PASSAGE OF A HURRICANE. DIFFERENCE ANALYSES WERE CONSTRUCTED FOR THE INITIAL SEA SURFACE TEMPERATURE AT EACH STATION AFTER TWENTY-FOUR HOURS OF SIMULATED WITHDRAWAL. THE DIFFERENCES RANGED FROM LESS THAN ONE DEGREE TO OVER FOUR DEGREES. AGAIN, NO CONSISTENT PATTERN WAS FOUND BUT GENERALLY AREAS OF HIGH CONCENTRATIONS OF HEAT EXPERIENCED SMALLER DECREASES. ACTUAL SEA SURFACE TEMPERATURES COLLECTED AFTER TWO HURRICANES WERE THEN ANALYZED AND COMPARED TO TEMPERATURE PATTERN PREDICTED BY THE COMPUTER MODEL. ILLUSTRATIONS OF THE RELATIVE AVAILABILITY OF SENSIBLE HEAT ENERGY FOR DIFFERENT SEA SURFACE TEMPERATURES ARE PRESENTED AND A HYPOTHESIS MADE TO ACCOUNT FOR THE GREATER THAN AVERAGE INTENSITIES OF HURRICANES BETSY (1965) AND CAMILLE (1969). (WOODARD-USGS) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-713 052, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MS THESIS, NAVAL POSTGRADUATE SCHOOL, SEPT 1970. 55 P, 16 FIG, 1 TAB, 16 REF. AU - James Jenson, Jack AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF. DEPT. OF OCEANOGRAPHY Y1 - 1970/09// PY - 1970 DA - Sep 1970 KW - Water Resources Abstracts KW - *WATER TEMPERATURE KW - *GULF OF MEXICO KW - *HURRICANES KW - SURFACE WATERS KW - METEROLOGICAL DATA KW - MODEL STUDIES KW - COMPUTER MODELS KW - HYDROLOGIC DATA KW - FORECASTING KW - HEAT TRANSFER KW - ADVECTION KW - CONVECTION KW - THERMAL STRATIFICATION KW - OCEANOGRAPHY KW - DATA COLLECTIONS KW - OCEAN-TEMPERATURE CHANGES(HURRICANES) KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19021963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=CALCULATED+AND+OBSERVED+CHANGES+IN+SEA+SURFACE+TEMPERATURE+ASSOCIATED+WITH+HURRICAN+PASSAGE&rft.au=James+Jenson%2C+Jack&rft.aulast=James+Jenson&rft.aufirst=Jack&rft.date=1970-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - VARIATION OF LONGSHORE CURRENT ACROSS THE SURF ZONE AN - 19015379; 7203095 AB - THE WAVE-INDUCED LONGSHORE CURRENT VARIATION ACROSS THE SURF ZONE IS DESCRIBED FOR A SIMPLIFIED MODEL, USING AS BASIC ASSUMPTIONS THAT THE CONDITIONS ARE STEADY, THE BOTTOM CONTOURS ARE STRAIGHT AND PARALLEL BUT ALLOW FOR AN ARBITRARY BOTTOM PROFILE, THE WAVES ARE ADEQUATELY DESCRIBED BY LINEAR THEORY, AND THAT SPILLING BREAKERS EXIST ACROSS THE SURF ZONE. CONSERVATION EQUATIONS OF MASS, MOMENTUM, AND ENERGY, SEPARATED INTO THE STEADY AND UNSTEADY COMPONENTS, ARE USED TO DESCRIBE SECOND-ORDER-WAVE-INDUCED PHENOMENA OF SHOALING WAVES APPROACHING AT AN ANGLE TO THE BEACH. AN EXPRESSION FOR THE LONGSHORE CURRENT IS BASED ON THE ALONGSHORE COMPONENT OF EXCESS MOMENTUM FLUX DUE TO THE PRESENCE OF UNSTEADY WAVE MOTION. WAVE SET-DOWN AND SET-UP ARE INCLUDED IN THE FORMULATION. COMPARISON WITH EXPERIMENTAL RESULTS FROM THE LABORATORY AND FIELD SHOW THAT IF THE ASSUMED CONDITIONS ARE APPROXIMATELY FULFILLED, THE PREDICTED RESULTS COMPARE QUITE FAVORABLY. (SEE ALSO W72-03078) (KNAPP-USGS) JF - PROCEEDINGS OF THE TWELFTH COASTAL ENGINEERING CONFERENCE, SEPTEMBER 13-18, 1970, WASHINGTON, DC, VOLUME 1; AMERICAN SOCIETY OF CIVIL ENGINEERS, NEW YORK, NY, P 291-308, 1970. 3 FIG, 9 REF. AU - Thornton, E B AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1970/09// PY - 1970 DA - Sep 1970 KW - Water Resources Abstracts KW - *SURF KW - *LITTORAL DRIFT KW - *CURRENTS(WATER) KW - *WAVES(WATER) KW - SHEAR STRESS KW - SEDIMENT TRANSPORT KW - SEDIMENTATION KW - MATHEMATICAL MODELS KW - ROUGHNESS(HYDRAULIC) KW - BEACH EROSION KW - COASTAL ENGINEERING KW - LONGSHORE CURRENTS KW - SW 6020:Hydraulics KW - SW 0835:Streamflow and runoff UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19015379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=VARIATION+OF+LONGSHORE+CURRENT+ACROSS+THE+SURF+ZONE&rft.au=Thornton%2C+E+B&rft.aulast=Thornton&rft.aufirst=E&rft.date=1970-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - TRAVELING CORRELATION FUNCTION OF THE HEIGHTS OF WIND-BLOWN WATER WAVES AN - 18995195; 7009689 AB - A WIND-BLOWN WATER SURFACE CAN BE CHARACTERIZED IN TERMS OF A TRAVELING CORRELATION FUNCTION IN WHICH THE GROUP AND PHASE VELOCITIES ARE GIVEN BY THE VALUES AT THE FREQUENCY OF MAXIMUM SPECTRAL ENERGY DENSITY. THE TWO-DIMENSIONAL (SPACE AND TIME) SURFACE DISPLACEMENT CORRELATION FUNCTION HAS BEEN MEASURED FOR LOW-DIVERGENCE WIND-BLOWN WAVES IN A LABORATORY TANK. THE MEASURED PHASE AND GROUP VELOCITIES OF THE CORRELATION FUNCTION AGREED WITH THEORETICAL VALUES FOR THE PEAK FREQUENCY WATER-WAVE COMPONENT WHEN THE MEASUREMENTS WERE TRANSFORMED TO COORDINATES THAT HAD THE VELOCITY OF THE SURFACE (DRIFT) CURRENT. THIS DESCRIPTION, WHICH MAY BE USEFUL IN THE OCEAN AS WELL, HAS RECENTLY BEEN USED TO PREDICT THE TEMPORAL CORRELATION OF SOUND SCATTERED FROM A MODEL SEA OF KNOWN THREE-DIMENSIONAL SURFACE CORRELATION FUNCTION. (KNAPP-USGS) JF - JOURNAL OF GEOPHYSICAL RESEARCH, VOL 75, NO 24, P 4519-4524, AUGUST 20, 1970. 6 P, 5 FIG, 1 TAB, 23 REF. AU - MEDWIN, H AU - Clay, C S AU - Berkson, J M AU - Jaggard, D L AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF. DEPT OF PHYSICS; AND WISCONSIN UNIV., MIDDLETOWN. GEOPHYSICAL AND POLAR RESEARCH CENTER Y1 - 1970/08// PY - 1970 DA - Aug 1970 KW - Water Resources Abstracts KW - *WAVES(WATER) KW - *MODEL STUDIES KW - HYDRAULIC MODELS KW - MATHEMATICAL MODELS KW - OCEAN WAVES KW - WINDS KW - MATHEMATICAL STUDIES KW - STATISTICAL MODELS KW - CORRELATION ANALYSIS KW - WAVE TANKS KW - SW 0835:Streamflow and runoff UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18995195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=TRAVELING+CORRELATION+FUNCTION+OF+THE+HEIGHTS+OF+WIND-BLOWN+WATER+WAVES&rft.au=MEDWIN%2C+H%3BClay%2C+C+S%3BBerkson%2C+J+M%3BJaggard%2C+D+L&rft.aulast=MEDWIN&rft.aufirst=H&rft.date=1970-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - FORMATION OF HYDRAULIC JUMPS IN A ROTATING SYSTEM AN - 18986894; 7007354 AB - THE FORMATION OF HYDRAULIC JUMPS IN A ROTATING, HOMOGENEOUS, ONE-LAYER FLUID IS INVESTIGATED. A SCALE ANALYSIS INDICATES THAT JUMP-FORMATION CASES SHOULD BE SEPARATED FROM NONJUMP CASES BY A CURVE IN WHICH THE FROUDE NUMBER IS PROPORTIONAL TO THE SQUARE OF THE ROSSBY NUMBER. NUMERICAL SOLUTIONS VERIFY THE CURVE UP TO F = 0.33 AND SHOW THAT THE COEFFICIENT OF PROPORTIONALITY IS IN THE RANGE 6.0-7.5. THE SOLUTIONS FOR F = 1.0 ARE EXAMINED IN CONSIDERABLE DETAIL. JUMPS CAN OCCUR IN THE NONJUMP REGION WHEN LARGE EVOLUTION TIMES ARE ALLOWED. THIS RELATION HAS SEVERAL POSSIBLE APPLICATIONS IN METEOROLOGY AND OCEANOGRAPHY. INTERNAL WAVES IN THE OCEAN ARE AFFECTED BY ROTATION, AND THE BREAKING OF THESE WAVES SHOULD BE DESCRIBED BY THE MODEL. HYDRAULIC JUMPS MAY ALSO BE IMPORTANT IN STORM SURGE PREDICTION. (KNAPP-USGS) JF - JOURNAL OF GEOPHYSICAL RESEARCH, VOL 75, NO 15, P 2813-2821, MAY 20, 1970. 9 P, 9 FIG, 13 REF. NSF GRANT GA-849. AU - Williams, R T AU - Hori, A M AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF., AND UTAH UNIV., SALT LAKE CITY Y1 - 1970/05// PY - 1970 DA - May 1970 KW - Water Resources Abstracts KW - *HYDRAULIC JUMP KW - *MATHEMATICAL STUDIES KW - *HYDRAULICS KW - *ROTATIONAL FLOW KW - *HYDRODYNAMICS KW - FROUDE NUMBER KW - SURGES KW - TURBULENT FLOW KW - ROSSBY NUMBER KW - ROTATING FLUID SYSTEMS KW - SW 6020:Hydraulics KW - SW 0835:Streamflow and runoff UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18986894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=FORMATION+OF+HYDRAULIC+JUMPS+IN+A+ROTATING+SYSTEM&rft.au=Williams%2C+R+T%3BHori%2C+A+M&rft.aulast=Williams&rft.aufirst=R&rft.date=1970-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A Pebble-Cobble Deposit in Monterey Bay, California AN - 19171170; 7709228 AB - A deposit of pebbles and cobbles was discovered in approximately 60 fm of water on the continental shelf in Monterey Bay, California. Samples were taken in the area and the extent of the deposit was determined. The material was characterized well as rounded, moderately well sorted coarse pebbles derived mainly for the granites of the Santa Lucia Formation with lesser amounts of alluvium from the Salinas Drainage Basin which flows into Monterey Bay. It was established that the deposit probably represents a marine terrace of Pleistocene Age, indicating a relative lowering of sea level of about 300 to 360 ft. This appears to be the first reported evidence of submerged marine terraces in Northern California. (Sinha-OEIS) JF - Available from the National Technical Information Service, Springfield VA 22161 as AD-A021 297, Price codes: A03 in paper copy, A01 in microfiche. Master 's Thesis, June 1970. 46 p, 10 fig, 3 tab, 18 ref. AU - Malone, MJ AD - Naval Postgraduate School Monterey, Calif Y1 - 1970/04// PY - 1970 DA - Apr 1970 KW - Water Resources Abstracts KW - Baseline studies KW - Continental Shelf KW - California KW - Sediment deposition KW - Water resources KW - Geology KW - Sediments KW - Pleistocene epoch KW - Bays KW - SW 0870:Erosion and sedimentation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19171170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+Pebble-Cobble+Deposit+in+Monterey+Bay%2C+California&rft.au=Malone%2C+MJ&rft.aulast=Malone&rft.aufirst=MJ&rft.date=1970-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SPECIFIC GRAVITY DETERMINATION OF MARINE SEDIMENTS AN - 19008284; 7100461 AB - ACCURATE SPECIFIC GRAVITY MEASUREMENTS ARE REQUIRED FOR THE ANALYSIS OF PHYSICAL PROPERTIES OF MARINE SEDIMENTS. APPLICATION OF THE BOTTLE PYCNOMETER TECHNIQUE, THE STANDARD DETERMINATION METHOD, IS TIME-CONSUMING, TEDIOUS, AND PERHAPS SUBJECT TO INACCURACIES IN THE CASE OF FINE PARTICULATE MATTER. A REVIEW OF METHODS CURRENTLY IN USE WAS CONDUCTED TO ASCERTAIN THE PRESENT STATE OF THE ART AND REVEAL ANY NEW DEVELOPMENTS IN THIS FIELD. SPECIFIC GRAVITY VALUES FOR THREE OPERATING MODES OF THE AIR COMPARISON PYCNOMETER, TWO OF WHICH USE HELIUM, WERE COMPARED WITH BOTTLE PYCNOMETER VALUES FOR FOUR TEST MATERIALS. THE AIR COMPARISON PYCNOMETER DETERMINATIONS, REGARDLESS OF OPERATING MODE, RESULTED IN HIGHER SPECIFIC GRAVITIES THAN THEIR COUNTERPART BOTTLE PYCNOMETER VALUES FOR KAOLINITE, MONTMORILLONITE, AND MARINE SEDIMENT SAMPLES. THE USE OF HELIUM AS THE COMPARISON MEDIUM IN THE AIR COMPARISON PYCNOMETER APPEARS TO REDUCE THE SURFACE ACTIVE CHARACTERISTICS OF THE COLLOIDAL MATERIAL. SPECIFIC GRAVITY DETERMINATIONS BY ALL FOUR TEST METHODS AGREED VERY WELL FOR POWDERED QUARTZ SAMPLES WITH A KNOWN SPECIFIC GRAVITY. JF - AVAILABLE FROM NTIS AS AD-706 731, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MS THESIS, APRIL 1970. 124 P. AU - Henderson, Joseph C AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1970/04// PY - 1970 DA - Apr 1970 KW - Water Resources Abstracts KW - *OCEAN BOTTOM KW - DENSITY KW - *SPECIFIC GRAVITY KW - DENSIMETERS KW - KAOLINITE KW - MONTMORILLONITE KW - COLLOIDS KW - TEST METHODS KW - QUARTZ KW - THESES KW - NAVAL RESEARCH KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19008284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SPECIFIC+GRAVITY+DETERMINATION+OF+MARINE+SEDIMENTS&rft.au=Henderson%2C+Joseph+C&rft.aulast=Henderson&rft.aufirst=Joseph&rft.date=1970-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - AN ECOLOGICAL SURVEY OF A SANDY BEACH AN - 19004180; 7100418 AB - AN ECOLOGICAL SURVEY OF A SANDY BEACH WAS MADE TO DETERMINE RELATIONSHIPS BETWEEN POPULATION DENSITIES AND SAND GRAIN SIZE DISTRIBUTIONS, SEASON AND HEIGHT ABOVE THE TIDAL DATUM PLANE (MLLW). FIFTEEN SPECIES OF INVERTEBRATES IN FOUR PHYLA WERE COLLECTED. FOUR ZONES RELATIVE TO TIDAL DATUM AND TWO MAJOR HABITATS - PROTECTED OUTER COAST SANDY BEACH AND OUTER COAST SANDY BEACH - WERE DEFINED. NEPHTYS CALIFORNIENSIS AND ARCHAEOMYSIS MACULATA SHOWED DISTINCTIVE DISTRIBUTION PATTERNS RELATIVE TO MEAN GRAIN SIZE WHICH REQUIRE FURTHER INVESTIGATION. JF - AVAILABLE FROM NTIS AS AD-709 087, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MS THESIS, APRIL 1970. 42 P. AU - Joseph Berger, Thomas AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1970/04// PY - 1970 DA - Apr 1970 KW - Water Resources Abstracts KW - *BEACHES KW - *ECOLOGY KW - ENVIRONMENT KW - SAND KW - GRAIN SIZE KW - INVERTEBRATES KW - TIDES KW - ANNELIDA KW - ARTHROPODS KW - CRUSTACEA KW - THESIS KW - NEPHTYS CAECOIDES KW - NEPHTYS CALIFORNIENSIS KW - ARCHAEOMYSIS MACULATA KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19004180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=AN+ECOLOGICAL+SURVEY+OF+A+SANDY+BEACH&rft.au=Joseph+Berger%2C+Thomas&rft.aulast=Joseph+Berger&rft.aufirst=Thomas&rft.date=1970-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A DISPERSION MODEL FOR HEATED EFFLUENT FROM AN OCEAN OUTFALL AN - 19001263; 7102605 AB - A MATHEMATICAL MODEL IS DEVELOPED FOR DISPERSION OF A HEATED EFFLUENT FROM AN OCEAN OUTFALL. INPUT PARAMETERS INCLUDE ATMOSPHERIC AND OCEANIC CONDITIONS AND DISCHARGE CHARACTERISTICS. THE MODEL SOLVES THE STEADY-STATE, TWO-DIMENSIONAL DIFFERENTIAL EQUATION FOR NON-CONSERVATIVE DIFFUSION OF HEAT IN A MOVING FLUID. THE SOLUTION IS CALIBRATED AND VERIFIED USING DATA FROM SURVEYS CONDUCTED AT THE SOUTHERN CALIFORNIA EDISON COMPANY POWER PLANT AT HUNTINGTON BEACH, CALIFORNIA. TEMPERATURE FIELDS PREDICTED BY THE MODEL ARE COMPARED WITH THE ACTUAL FIELDS FOR SEVEN DIFFERENT SURVEYS. THESE COMPARISONS INDICATE THAT THE MODEL CAN BE USED TO PREDICT THE LARGE SCALE INFLUENCE OF THE OUTFALL ON THE LOCAL OCEAN ENVIRONMENT. JF - AVAILABLE FROM NTIS AS AD-710 730, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MASTER'S THESIS, APRIL 1970. 58 P, 13 FIG, 3 TAB, 28 REF. AU - Charles Baldwin, Richard AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1970/04// PY - 1970 DA - Apr 1970 KW - Water Resources Abstracts KW - *SEA WATER KW - HEAT TRANSFER KW - *WASTES(INDUSTRIAL) KW - DISPOSAL KW - *POWER PLANTS(ESTABLISHMENTS) KW - HEAT KW - COOLING KW - TWO-DIMENSIONAL FLOW KW - MATHEMATICAL MODELS KW - FLUID FLOW KW - SURFACE TEMPERATURES KW - PACIFIC OCEAN KW - THESES KW - HEAT BUDGET KW - HEAT SINKS KW - *HUNTINGTON BEACH(CALIF) KW - *THERMAL POLLUTION KW - SW 3020:Sources and fate of pollution KW - SW 4010:Techniques of planning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19001263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+DISPERSION+MODEL+FOR+HEATED+EFFLUENT+FROM+AN+OCEAN+OUTFALL&rft.au=Charles+Baldwin%2C+Richard&rft.aulast=Charles+Baldwin&rft.aufirst=Richard&rft.date=1970-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - INFLUENCE OF PESTICIDE RUN-OFF IN MONTEREY BAY AN - 18996286; 7106742 AB - EVIDENCE EXISTS SUGGESTING THAT RUNOFF FROM DDT TREATED FARMLANDS IN THE SALINAS RIVER VALLEY OF CALIFORNIA HAS RESULTED IN PESTICIDE (DDE) CONTAMINATION OF THE BENTHIC COMMUNITY AND THE BOTTOM SEDIMENTS OF MONTEREY BAY. THE SALINAS RIVER IS THE ONLY MAJOR TRIBUTARY ENTERING THE BAY. A BIRD KILL OCCURRED IN MONTEREY BAY IN 1969 AFTER EXTENSIVE SURFACE RUNOFF FROM THE SALINAS VALLEY. THE DEAD SEABIRDS CONTAINED DDE LEVELS AS HIGH OR HIGHER THAN ANYWHERE IN THE AREA: 805 PPM DDE IN THE LIVER OF A GULL, 412 PPM DDE IN THE LIVER OF A PETREL, AND 192-292 PPM DDE IN LIVERS OF WESTERN GREBES. A SURVEY BEING CONDUCTED ON THE BENTHIC COMMUNITY AND ON THE BOTTOM SEDIMENTS OF MONTEREY BAY IS DESCRIBED. IT IS HOPED THAT THIS WILL YIELD A BETTER UNDERSTANDING OF THE BENTHIC COMMUNITY OF MONTEREY BAY AND OF THE ROLE PLAYED IN ECOLOGICAL CYCLES BY HEAVY METALS AND BY PESTICIDES. (KATZ - WASHINGTON) JF - MARINE POLLUTION BULLETIN, VOL 1(NS), NO 3, P 42-43, MARCH 1970. AU - Haderlie, E C AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF. DEPT. OF OCEANOGRAPHY Y1 - 1970/03// PY - 1970 DA - Mar 1970 KW - Water Resources Abstracts KW - *DDT KW - *PESTICIDE DRIFT KW - *PESTICIDE RESIDUES KW - *WATER POLLUTION KW - *PESTICIDE TOXICITY KW - *SURFACE RUNOFF KW - *ON-SITE INVESTIGATIONS KW - PESTICIDE KINETICS KW - WATER POLLUTION EFFECTS KW - AQUATIC BIRDS KW - GAS CHROMATOGRAPHY KW - GULLS KW - CRABS KW - BOTTOM SEDIMENTS KW - BENTHIC FAUNA KW - ESTUARINE ENVIRONMENT KW - SEA LIONS KW - SALINAS RIVER KW - TISSUE ANALYSIS KW - CALIFORNIA KW - HEAVY METALS KW - *MONTEREY BAY(CALIFORNIA) KW - BIRD KILL KW - CORMORANTS KW - GREBES KW - PETRELS KW - SW 3020:Sources and fate of pollution KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18996286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=INFLUENCE+OF+PESTICIDE+RUN-OFF+IN+MONTEREY+BAY&rft.au=Haderlie%2C+E+C&rft.aulast=Haderlie&rft.aufirst=E&rft.date=1970-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - AN OCEANOGRAPHIC SURVEY OF THE COASTAL WATERS BETWEEN SAN FRANCISCO BAY AND MONTEREY BAY, CALIFORNIA AN - 19002419; 7101152 AB - A DETAILED OCEANOGRAPHIC SURVEY OF THE COASTAL WATERS BETWEEN MONTEREY BAY AND SAN FRANCISCO BAY, CALIFORNIA, WAS CONDUCTED FROM 10 THROUGH 18 MAY 1969. MEASUREMENTS OF BEAM TRANSMITTANCE, SOUND VELOCITY, TEMPERATURE, AND PARTICULATE COUNT WERE OBTAINED. OVER 500 WATER SAMPLES WERE TAKEN FOR PARTICULATE ANALYSIS. THE OPTICAL PROPERTIES OF THIS REGION WERE FOUND TO BE VERY COMPLEX. THE WATERS APPEARED TO BE AFFECTED BY FLOW FROM SAN FRANCISCO BAY, LITTORAL MATERIAL, UPWELLING, AND POSSIBLY SEWAGE OUTFALLS DURING THE SURVEY. A GREATER VOLUME OF WATER WITH LOW TRANSMISSIVITY AND HIGH PARTICLE COUNT EXISTED IN THE NORTHERN REGION OF THE SURVEY AREA THAN IN THE SOUTHERN REGION. AN EDDY SYSTEM BETWEEN MONTEREY BAY AND POINT ANO NUEVO WAS SUGGESTED. APPROXIMATELY 90 PERCENT OF THE PARTICLES AFFECTING BEAM TRANSMITTANCE WERE LESS THAN 12 MICRONS IN DIAMETER. PARTICLE SIZES WERE FOUND TO DECREASE WITH INCREASED DEPTHS. A FAIRLY GOOD CORRELATION OF BEAM TRANSMITTANCE WITH PARTICLE COUNT WAS OBSERVED EXCEPT IN NEAR SHORE AREAS. JF - AVAILABLE FROM NTIS AS AD-703 645, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. MASTER'S THESIS, OCTOBER 1969. 316 P. AU - Stephen Labyak, Peter AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1969/10// PY - 1969 DA - Oct 1969 KW - Water Resources Abstracts KW - *SEA WATER KW - OPTICAL PROPERTIES KW - UNDERWATER SOUND KW - SOUND TRANSMISSION KW - TEMPERATURE KW - SALINITY KW - DENSITY KW - OXYGEN KW - PHOSPHATES KW - NITROGEN COMPOUNDS KW - HYDROGRAPHIC SURVEYING KW - BATHYTHERMOGRAPH DATA KW - THESES KW - MONTEREY BAY KW - SAN FRANCISCO BAY KW - LITORAL DRIFT KW - UPWELLING KW - *OPTICAL OCEANOGRAPHY KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19002419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=AN+OCEANOGRAPHIC+SURVEY+OF+THE+COASTAL+WATERS+BETWEEN+SAN+FRANCISCO+BAY+AND+MONTEREY+BAY%2C+CALIFORNIA&rft.au=Stephen+Labyak%2C+Peter&rft.aulast=Stephen+Labyak&rft.aufirst=Peter&rft.date=1969-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - LONG WAVE PROPAGATION IN A TRIANGULAR CHANNEL AN - 18997606; 7101137 AB - THE PURPOSE OF THE PAPER IS TO EXAMINE LONG WAVE PROPAGATION IN A SHALLOW CHANNEL OF TRIANGULAR CROSS SECTION. SOLUTIONS FOR SMALL SCALE (F=O), LARGE SCALE (F NOT = O), SYMMETRIC AND ASYMMETRIC CHANNELS ARE OBTAINED. RESULTS ARE SHOWN TO BE CONSISTENT WITH EARLIER WORK FOR THE FUNDAMENTAL MODE (M = O), AND WITH EDGEWAVE SOLUTIONS OVER A GENTLY SLOPING BOTTOM FOR THE HIGHER MODES. A SECOND CLASS OF WAVES (QUASI-GEOSTROPHIC WAVES) IS ALSO OBTAINED WHEN THE CORIOLIS EFFECT IS INCLUDED. THE RESULTS ARE COMPARED WITH THOSE FOR A RECTANGULAR CHANNEL. JF - AVAILABLE FROM NTIS AS AD-703 238, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. OCTOBER, 1969. 46 P. MS THESIS. AU - Toft Bowman, William AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1969/10// PY - 1969 DA - Oct 1969 KW - Water Resources Abstracts KW - *SHALLOW WATER KW - WATER WAVES KW - *WATER WAVES KW - PROPAGATION KW - LAMINAR FLOW KW - EQUATIONS OF MOTION KW - HYDRODYNAMICS KW - NUMERICAL ANALYSIS KW - CORIOLIS EFFECT KW - THESES KW - CHANNEL FLOW KW - SW 6020:Hydraulics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18997606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=LONG+WAVE+PROPAGATION+IN+A+TRIANGULAR+CHANNEL&rft.au=Toft+Bowman%2C+William&rft.aulast=Toft+Bowman&rft.aufirst=William&rft.date=1969-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - HEAVY MINERAL INVESTIGATION OF CARMEL BAY BEACH SANDS AN - 18994619; 7100809 AB - THE INVESTIGATION WAS CONDUCTED IN ORDER TO IDENTIFY THE HEAVY MINERALS OF THE BEACH SANDS OF CARMEL BAY, AND TO ANALYZE THE DISTRIBUTION OF THESE MINERALS. CARMEL BAY OFFERS THE OPPORTUNITY TO STUDY HEAVY MINERAL ASSEMBLAGES IN A SMALL ISOLATED BAY, INTERNALLY DIVIDED BY A SUBMARINE CANYON, CONTAINING SMALLER POCKET BEACHES INFLUENCED BY SEVERAL GEOLOGICAL FORMATIONS, AND TWO FRESH WATER STREAMS. CORRELATION OF THE HEAVY MINERAL ASSEMBLAGE OF EACH SAMPLE WITH THE SAMPLE LOCATION CLEARLY INDICATE THAT THE BEACH SANDS CAN BE DIVIDED INTO TWO PRINCIPAL MINERAL SUITES THAT ARE DERIVATIVES OF THE GEOLOGICAL FORMATIONS IN IMMEDIATE CONTACT WITH THE INDIVIDUAL POCKET BEACHES. THE UNIQUE NATURE OF EACH SUITE IS PRESERVED BY NATURAL OBSTRUCTIONS THAT LIMIT THE INFLUENCE OF LITTORAL DRIFT AND RESTRICT THE EXCHANGE OF THE BEACH SANDS. JF - AVAILABLE FROM NTIS AS AD 704 078, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. OCTOBER 1969, 48 P. MS THESIS. AU - Adolph Griffin, Paul AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1969/10// PY - 1969 DA - Oct 1969 KW - Water Resources Abstracts KW - *MINERALS KW - CALIFORNIA KW - *BEACHES KW - ANALYSIS KW - SAND KW - TRANSPORT PROPERTIES KW - SAMPLING KW - PETROGRAPHY KW - GARNET KW - GEOLOGIC AGE DETERMINATION KW - SEASCOAST KW - THESES KW - CARMEL BAY KW - LITTORAL DRIFT KW - *HEAVY MINERAL ANALYSIS KW - SCHISTS KW - AUGITES KW - SW 0870:Erosion and sedimentation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18994619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=HEAVY+MINERAL+INVESTIGATION+OF+CARMEL+BAY+BEACH+SANDS&rft.au=Adolph+Griffin%2C+Paul&rft.aulast=Adolph+Griffin&rft.aufirst=Paul&rft.date=1969-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THERMAL STRATIFICATION IN THE ARCTIC OCEAN AN - 18977573; 7000638 AB - SOPHISTICATED ELECTRONIC SYSTEMS NOW IN USE BY OCEANOGRAPHERS TO OBTAIN CONTINUOUS TEMPERATURE AND SALINITY PROFILES SHOW THAT THE VERTICAL TEMPERATURE PROFILE IN THE OCEANS MAY BE COMPLEX. FINE SCALE VERTICAL TEMPERATURE MEASUREMENTS IN AN ARCTIC WATER COLUMN ARE DESCRIBED; THEY SHOW THE PRESENCE OF SEVERAL CASCADED ISOTHERMAL LAYERS. LAYERS BETWEEN DEPTHS OF 300 AND 350 METERS RANGE FROM 2 TO 10 METERS IN THICKNESS, WHILE THE TEMPERATURE CHANGE BETWEEN ADJACENT LAYERS IS APPROXIMATELY 0.026 DEG C. THE INDIVIDUAL LAYERS ARE ISOTHERMAL TO WITHIN PLUS OR MINUS 0.001 DEG C. (LANG-USGS) JF - SCIENCE, VOL 166, NO 3903, P 373-374, OCT 1969. 2 P, 1 FIG, 4 REF. AU - Neal, V T AU - Neshyba, S AU - Denner, W AD - OREGON STATE UNIV., CORVALLIS; AND NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1969/10// PY - 1969 DA - Oct 1969 KW - Water Resources Abstracts KW - *THERMAL STRATIFICATION KW - *ARCTIC OCEAN KW - *ELECTRONIC EQUIPMENT KW - INTERFACES KW - ISOTHERMS KW - DENSITY CURRENTS KW - HEAT FLOW KW - MASS TRANSFER KW - DEEP WATER KW - METHODOLOGY KW - *THERMAL STRUCTURE KW - VERTICAL PROFILES KW - DEEP SEA RESEARCH KW - SW 5040:Data acquisition KW - SW 0820:Snow, ice and frost UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18977573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THERMAL+STRATIFICATION+IN+THE+ARCTIC+OCEAN&rft.au=Neal%2C+V+T%3BNeshyba%2C+S%3BDenner%2C+W&rft.aulast=Neal&rft.aufirst=V&rft.date=1969-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THE EFFECT OF WAVES ON THE PROFILE OF A NATURAL BEACH AN - 19082487; 7404620 AB - A 60-DAY STUDY WAS CONDUCTED ON A SELECTED NATURAL BEACH IN WHICH THE BEACH PROFILE WAS MEASURED DAILY AND THE WAVES INCIDENT UPON THE PROFILE WERE RECORDED CONTINUOUSLY. BEACH AND WAVE PARAMETERS DERIVED FROM THE FIELD DATA WERE EMPIRICALLY COMBINED TO YIELD: (A) QUANTITATIVE RELATIONSHIPS BETWEEN THE CHANGE IN THE PROFILE AND THE AVERAGE DEEP-WATER WAVE STEEPNESS AND WAVE POWER OVER A LUNAR DAY (24.8) HOURS GIVEN THE PROFILE AT THE BEGINNING OF THE PERIOD, (B) EQUILIBRIUM PROFILES FOR DIFFERENT VALUES OF WAVE STEEPNESS, (C) AN EMPIRICAL RELATIONSHIP BETWEEN WAVE STEEPNESS AND WAVE POWER WHICH AGREES WELL WITH THEORY, AND (D) RATES AT WHICH THE BEACH PROFILE APPROACHED EQUILIBRIUM FOR GIVEN INITIAL CONDITIONS OF NON-EQUILIBRIUM. USING THE RELATIONSHIP DEVELOPED BETWEEN BEACH CHANGE AND WAVE STEEPNESS, HINDCASTS WERE MADE OF THE DAY-TO-DAY SAND ELEVATION AT A SELECTED LOCATION NEAR THE MIDDLE OF THE PROFILE AND WERE FOUND TO AGREE FAIRLY WELL WITH THE OBSERVED SAND LEVEL. (SINHA - OEIS) JF - IN: PROCEEDINGS OF ELEVENTH CONFERENCE ON COASTAL ENGINEERING, LONDON, ENGLAND, SEPTEMBER 1968. AMERICAN SOCIETY OF CIVIL ENGINEERS, VOL 1, PART 2, CHAP 23, P 352-372, 1969. 8 FIG, 8 REF. AU - Thompson, W C AU - HARLETT, J C AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1969/09// PY - 1969 DA - Sep 1969 KW - Water Resources Abstracts KW - *BEACHES KW - *WAVES(WATER) KW - *PROFILES KW - *SEDIMENTATION KW - *WAVE STEEPNESS KW - EQUILIBRIUM PROFILES KW - *HINDCASTS KW - SW 0870:Erosion and sedimentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19082487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THE+EFFECT+OF+WAVES+ON+THE+PROFILE+OF+A+NATURAL+BEACH&rft.au=Thompson%2C+W+C%3BHARLETT%2C+J+C&rft.aulast=Thompson&rft.aufirst=W&rft.date=1969-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - AN INVESTIGATION OF BOTTOM CHANGES IN MONTEREY HARBOR (1932-1969) AN - 19086576; 7404211 AB - BOTTOM CHANGES OCCURRING IN MONTEREY HARBOR FROM 1932-1969 WERE ANALYZED BY NUMERICAL COMPUTER METHODS USING 15 SELECTED HYDROGRAPHIC SURVEYS. RESULTS INDICATE THAT THE MAJOR PORTION OF THE HARBOR HAS BEEN SHOALING IN THE MEAN SINCE 1932. THE LONG-TERM SHOALING RATE HAS BEEN 0.4 TO 4.0 FEET PER DECADE IN THE BEACH AND NEARSHORE ZONES AND ALONG THE BREAKWATER; AND LESS THAN 0.25 FEET PER DECADE IN THE STABLE OUTER HARBOR. THE ACCRETION RATE AVERAGED 17,500 CUBIC YARDS PER YEAR FROM 1932-1969 BUT ONLY 7,100 CUBIC YARDS PER YEAR FOR 1947 TO 1969. THE SHOALING IS BELIEVED DUE TO THE CONSTRUCTION OF THE COAST GUARD BREAKWATER IN 1931-1934. IT IS DEDUCED THAT PRIOR TO 1960 THE EXCESS SAND WAS CARRIED INTO THE HARBOR BY LITTORAL TRANSPORT FROM DEL MONTE BEACH AND BY WAVE CURRENTS AROUND THE BREAKWATER. CONSTRUCTION OF THE SOLID WALL ON WARF 2 IN 1960 CUT OFF THE FORMER SAND SUPPLY. LOCAL REDISTRIBUTION OF SAND IN THE BEACH AND NEARSHORE ZONES OF THE HARBOR IS LARGE AND RESULTS IN AREAS OF SIGNIFICANT ACCRETION AND EROSION BETWEEN SURVEYS. DREDGING OPERATIONS HAVE HAD ONLY SHORT-TERM EFFECTIVENESS BECAUSE THE SPOIL HAS BEEN RETAINED WITHIN THE HARBOR. (SINHA-OEIS) JF - AVAILABLE FROM NTIS AS AD-706 032, FOR $3.00 PAPER COPY, $1.45 MICROFICHE. MS THESIS, JUNE 1969. 179 P, 12 FIG, 4 TAB, 8 REF, 6 APPEND. AU - Lennox, R J AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1969/06// PY - 1969 DA - Jun 1969 KW - Water Resources Abstracts KW - *HARBORS KW - *BEACHES KW - *SEDIMENT TRANSPORT KW - *WAVES(WATER) KW - *CALIFORNIA KW - SEDIMENTATION KW - BREAKWATERS KW - COASTS KW - COASTAL STRUCTURES KW - SANDS KW - MONTEREY HARBOR(CALIF) KW - *SHOALING KW - NEARSHORE KW - *BOTTOM TOPOGRAPHY KW - SW 6020:Hydraulics KW - SW 0870:Erosion and sedimentation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19086576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=AN+INVESTIGATION+OF+BOTTOM+CHANGES+IN+MONTEREY+HARBOR+%281932-1969%29&rft.au=Lennox%2C+R+J&rft.aulast=Lennox&rft.aufirst=R&rft.date=1969-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - SURFACE CHARACTERISTICS OF WINDROWS AN - 19091434; 7403618 AB - AERIAL PHOTOGRAPHS WERE TAKEN OF WINDROW ACCUMULATIONS IN MONTEREY BAY ON 1, 8, 15 AND 22 OCTOBER 1968. A FAIRCHILD T-11 AERIAL MAPPING CAMERA WAS USED, WITH PHOTOGRAPHS TAKEN APPROXIMATELY EVERY TWO MINUTES OVER 40 TO 60 MINUTE PERIODS. WINDROWS WERE MARKED WITH ACCUMULATIONS OF COMPUTER CARDS, WIND SPEED MEASURED BY CUP ANEMOMETER, AND WIND DIRECTION TAKEN WITH THE AID OF A MK.6 SMOKE FLOAT. SEA SURFACE TEMPERATURE, DEPTH OF THE THERMOCLINE, AND SURFACE AIR TEMPERATURE MEASUREMENTS WERE TAKEN CONCURRENTLY. AN ATTEMPT WAS MADE TO CORRELATE WINDROW SPACING AND WIND SPEED, TO FIND MEAN DEFLECTION OF WINDROWS RELATIVE TO THE WIND, TO DETERMINE ANY RELATIONSHIP BETWEEN ROW SPACING AND DEPTH OF THE THERMOCLINE, AND TO FIND THE RESPONSE TIME OF WINDROW ORIENTATION TO A WIND SHIFT. WINDROW SPACING WAS FOUND TO DEPEND ON OTHER FACTORS THAN WIND SPEED. DEFLECTION ANGLES VARIED BETWEEN 20 DEGREES LEFT AND 20 DEGREES RIGHT, WITH 0 DEGREES BEING THE MOST COMMON ANGLE. NO CORRELATION WAS FOUND BETWEEN DEPTH OF THE THERMOCLINE AND ROW SPACING. RESPONSE TIME FELL BETWEEN TWO AND FOUR MINUTES. (SINHA-OEIS) JF - AVAILABLE FROM NTIS AS AD-683 803, FOR $6.00 PAPER COPY, $1.45 MICROFICHE. M SC THESIS, DECEMBER 1968. 53 P, 16 FIG, 21 REF, 2 APPEND. AU - Ortengren, R W AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1968/12// PY - 1968 DA - Dec 1968 KW - Water Resources Abstracts KW - *CALIFORNIA KW - *WINDS KW - *AERIAL PHOTOGRAPHY KW - *BAYS KW - SURFACE WATER KW - COASTS KW - MONTEREY BAY(CA) KW - *WIND SLICKS KW - *WINDROWS KW - SW 5040:Data acquisition KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19091434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=SURFACE+CHARACTERISTICS+OF+WINDROWS&rft.au=Ortengren%2C+R+W&rft.aulast=Ortengren&rft.aufirst=R&rft.date=1968-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - THE SOUTHERN MONTEREY BAY LITTORAL CELL: A PRELIMINARY SEDIMENT BUDGET STUDY AN - 19064313; 7402695 AB - A SEDIMENT BUDGET WAS DEVELOPED FOR SOUTHERN MONTEREY BAY, CALIFORNIA. THIS BUDGET IS BASED UPON SEDIMENT INFORMATION OBTAINED FROM FIELD AND LABORATORY STUDIES. THESE STUDIES INCLUDED A DETAILED QUASI-SYNOPTIC AREAL SAMPLING TO DETERMINE DISTRIBUTION OF TEXTURAL PATTERNS, AND A TIME-SERIES STUDY OF BEACH AND SURF-ZONE SAND SAMPLES OBTAINED FROM LOCAL SAND-MINING COMPANIES. RESULTS WERE COMBINED WITH DATA ON RIVER DISCHARGE, THE WIND AND WAVE REGIMES, AND SHORELINE CHANGES DURING THE PAST CENTURY TO DEVELOP QUANTITATIVE ESTIMATES OF SEDIMENT GAINS AND LOSSES TO THE CELL. THE MAJOR SOURCES OF SEDIMENT ARE THE DISCHARGE FROM THE SALINAS RIVER WHICH EMPTIES INTO THE NORTHEAST CORNER OF THE CELL, AND EROSION OF QUATERNARY SEACLIFFS WHICH FORM THE INNER BAY SHORE. MAJOR SINKS ARE THE MONTEREY SUBMARINE CANYON, ACTIVE COASTAL DUNE FIELDS, THE MINING COMPANIES, AND THE OFFSHORE AREA. THE RECENT HISTORY OF THE SEDIMENT REGIME IN THE SOUTHERN BAY IS REVIEWED, AND A FORECAST OF FUTURE NEARSHORE CHANGES IS MADE. RECOMMENDATIONS FOR FURTHER WORK NEEDED TO REFINE THE BUDGET COMPUTATIONS ARE PRESENTED. (SINHA-OEIS) JF - AVAILABLE FROM NTIS AS AD-683 662, $6.00 IN PAPER COPY. MSC THESIS, DECEMBER 1968. 234 P, 29 FIG, 5 TAB, 54 REF, 8 APPEND. AU - Dorman, Ce AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1968/12// PY - 1968 DA - Dec 1968 KW - Water Resources Abstracts KW - *CALIFORNIA KW - *SEDIMENT TRANSPORT KW - *BEACHES KW - *WAVES KW - *LITTORAL KW - RIVER FLOW KW - WINDS KW - EROSION KW - SEASONAL KW - BATHYMETRY KW - *MONTEREY BAY(CALIF) KW - SURF ZONE KW - NEAR SHORE KW - LONGSHORE TRANSPORT KW - MASS TRANSPORT KW - SW 0870:Erosion and sedimentation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19064313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=THE+SOUTHERN+MONTEREY+BAY+LITTORAL+CELL%3A+A+PRELIMINARY+SEDIMENT+BUDGET+STUDY&rft.au=Dorman%2C+Ce&rft.aulast=Dorman&rft.aufirst=Ce&rft.date=1968-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - FIELD OBSERVATIONS OF WAVE RUNOFF ON A SAND BEACH AN - 19209592; 7214362 AB - SIX SETS OF FIELD MEASUREMENTS OF RUNUP RESULTING FROM BOTH WIND WAVES AND SWELL WERE MADE ON A UNIFORM SAND BEACH. WAVES WERE RECORDED SIMULTANEOUSLY DIRECTLY OFFSHORE AT A POINT OUTSIDE THE SURF ZONE. EACH INDIVIDUAL RUNUP WAS CORRELATED WITH A SPECIFIC WAVE, USING A TRAVELTIME PLOT. RUNUP OCCURRENCES WERE ALWAYS FOUND TO BE FEWER IN NUMBER THAN WAVE OCCURRENCES, PARTICULARLY WHEN WIND WAVES WERE PRESENT. THERE WERE VARIATIONS IN THE RUNUP RESULTING FROM WAVES OF A GIVEN HEIGHT. THESE VARIATIONS INHEIGHT AND RATIO OF RUNUP TO WAVES WERE CAUSED IN LARGE PART BY THE INTERACTION OF SUCCESSIVE FOAM LINES. INTERACTION OCCURRED IN THE FORM OF RETARDATION BY BACKWASH OF PRECEDING WAVES, OVERTAKING BY A FOLLOWING FOAM LINE, AND OVERRIDING BY A SMALL UNBROKEN WAVE. THE COMPLICATED NATURE OF RUNUP RESULTING FROM ORDINARY SEA AND SWELL MAKES IT DIFFICULT TO PREDICT RUNUP ACCURATELY FROM LABORATORY STUDIES. (WOODARD-USGS) JF - AVAILABLE FROM NTIS, SPRINGFIELD, VA. 22151 AS AD-821 832. PRICE $3.00 PAPER COPY, 95 CENTS MICROFICHE. M SC THESIS IN OCEANOGRAPHY, JUNE 1967. 90 P, 10 FIG, 7 TAB, 11 REF, APPEND. AU - HOERNEMANN, MJ AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1967/04// PY - 1967 DA - Apr 1967 KW - Water Resources Abstracts KW - *OCEAN WAVES KW - *BEACHES KW - *SURF KW - *WAVES(WATER) KW - *VELOCITY KW - TIME KW - WINDS KW - ON-SITE DATA COLLECTIONS KW - TRAVEL TIME KW - MEASUREMENT KW - SEA SPRAY KW - WAVE PILE-UP KW - ANALYTICAL TECHNIQUES KW - CORRELATION ANALYSIS KW - PROPERTIES KW - WAVE RUNUP KW - SWELL KW - OFFSHORE WAVES KW - SW 5080:Evaluation, processing and publication KW - SW 0835:Streamflow and runoff UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19209592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=FIELD+OBSERVATIONS+OF+WAVE+RUNOFF+ON+A+SAND+BEACH&rft.au=HOERNEMANN%2C+MJ&rft.aulast=HOERNEMANN&rft.aufirst=MJ&rft.date=1967-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - MARINE FOULING ORGANISMS IN MONTEREY HARBOR, CALIFORNIA, JUNE THROUGH SEPTEMBER 1966 AN - 19273446; 7212671 AB - MARINE FOULING ORGANISMS OCCURRING ON TEST PANELS OF VARIOUS SUBSTANCES AND AT VARIOUS LOCATIONS AND DEPTHS OF THE MONTEREY HARBOR, CALIFORNIA, WERE STUDIED FOR IDENTIFICATION AND SIGNIFICANCE. SOME PANELS WERE IMMERSED FOR THE ENTIRE LENGTH OF THE STUDY--JUNE 10 TO SEPTEMBER 16, 1966; OTHERS, MAINLY PLYWOOD, WERE IMMERSED ONLY FOR MONTH-LONG PERIODS THROUGHOUT THE STUDY. BARNACLES, BRYOZOANS, AND SERPULIDS WERE THE MAJOR FOULING ORGANISMS IN THE INNER HARBOR, WHILE HYDROIDS WERE MOST SIGNIFICANT IN THE OUTER HARBOR. THE BARNACLES REACHED MAXIMUM ATTACHMENT IN JUNE AND JULY, BUT WERE COVERED LATER BY BRYOZOANS. PHORONID WORMS WERE ABUNDANT IN AUGUST AND SEPTEMBER ON THE SHALLOW PANELS IN THE INNER HARBOR. FOULING INCREASED WITH DEPTH AND DISTANCE AWAY FROM DIRECT SUNLIGHT. FIBROUS MASONITE AND WOOD PANELS WERE THE BEST COLLECTORS, AND STAINLESS STEEL WAS THE WORST. (KATZ-WASHINGTON) JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-805 628, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. M.S. THESIS, U.S. NAVAL POSTGRADUATE SCHOOL, 1966. 54 P, 14 FIG, 3 TAB, 17 REF, SUPP. AU - Miller, T L AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1966 PY - 1966 DA - 1966 KW - Water Resources Abstracts KW - *FOULING KW - *BOTTOM FAUNA KW - *PACIFIC COAST REGION KW - *INVERTEBRATES KW - MARINE ANIMALS KW - ANIMAL GROUPING KW - ON-SITE TESTS KW - SEASON KW - ANNUAL SUCCESSION KW - CALIFORNIA KW - WORMS KW - *MARINE FOULING ORGANISMS KW - *TEST PANELS KW - *BARNACLES KW - MONTEREY HARBOR(CALIF) KW - BRYOZOANS KW - SERPULIDS KW - HYDROIDS KW - PHORONID WORMS KW - SW 3010:Identification of pollutants KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19273446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=MARINE+FOULING+ORGANISMS+IN+MONTEREY+HARBOR%2C+CALIFORNIA%2C+JUNE+THROUGH+SEPTEMBER+1966&rft.au=Miller%2C+T+L&rft.aulast=Miller&rft.aufirst=T&rft.date=1966-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A STUDY OF WATER CIRCULATION IN MONTEREY HARBOR USING RHODAMINE B DYE AN - 19085197; 7403114 AB - RHODAMINE B DYE WAS USED TO DETERMINE WATER CIRCULATION IN MONTEREY HARBOR. POINT AND LINE DYE SOURCES WERE TRACED VISUALLY, PHOTOGRAPHICALLY, AND BY USE OF A FLUOROMETER. THE SPREADING OF DYE BOUNDARIES AND THE CONCENTRATIONS OBSERVED ARE PRESENTED IN A TIME SERIES OF SYNOPTIC CHARTS FOR EACH OF THE FOUR SURVEYS CONDUCTED. FROM THESE MEASUREMENTS, MEAN FLOW RATES AND A DYE DIFFUSION RATE WERE DETERMINED. CIRCULATION WAS FOUND TO BE DOMINATED BY TIDAL CURRENTS, BUT WIND-DRIVEN CURRENTS WERE IMPORTANT IN THE OUTER HARBOR. IN THE OUTER HARBOR, THE CIRCULATION PROVED TO BE COUNTERCLOCKWISE DURING RISING TIDE, AND CLOCKWISE DURING THE FALLING TIDE. FLOW WAS MINIMAL IN THE INNER HARBOR, OR MARINA. LIMITED DATA INDICATE THAT THE SUBSURFACE CIRCULATION AGREED WITH THE SURFACE CIRCULATION IN MOST OF THE SURVEYS. (SINHA - OEIS) JF - AVAILABLE FROM NTIS AS AD-618 881, $6.00 PAPER COPY, $1.45 MICROFICHE. MSC THESIS, 1965. 66 P, 20 FIG, 4 REF. AU - Breidenstein, F AU - Thomas, D M AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1965 PY - 1965 DA - 1965 KW - Water Resources Abstracts KW - *CALIFORNIA KW - *DYE DISPERSION KW - *WATER CIRCULATION KW - *HARBORS KW - *TIDAL EFFECTS KW - RHODAMINE KW - TRACERS KW - MONTEREY HARBOR(CALIF.) KW - *TIDAL CURRENTS KW - WIND DRIVEN CURRENTS KW - SW 3020:Sources and fate of pollution KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19085197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+STUDY+OF+WATER+CIRCULATION+IN+MONTEREY+HARBOR+USING+RHODAMINE+B+DYE&rft.au=Breidenstein%2C+F%3BThomas%2C+D+M&rft.aulast=Breidenstein&rft.aufirst=F&rft.date=1965-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - QUASI-WEEKLY AND DAILY PROFILE CHANGES ON A DISTINCTIVE SAND BEACH AN - 19086713; 7404964 AB - DEL MONTE BEACH, BECAUSE OF ITS SHELTERED LOCATION IN MONTEREY BAY, CALIFORNIA, PROVIDES A NATURAL LABORATORY FOR THE STUDY OF BEACH PROFILE CHANGES AND OTHER NEARSHORE PHENOMENA BY VIRTUE OF THE RELATIVE SIMPLICITY OF THE NATURAL CONDITIONS THAT PREVAIL THERE. EXTREME WAVE REFRACTION RESULTS IN A PREVALENCE OF SWELL OF LOW HEIGHT AND BREAKER ANGLE, BUT HAVING A WIDE RANGE OF PERIOD. COASTAL CURRENTS, TIDAL CURRENTS, AND METEOROLOGICAL TIDES ARE NEGLIGIBLE. THERE IS NO SIGNIFICANT NET LITTORAL DRIFT, ACCORDINGLY, CHANGES IN THE BEACH PROFILE APPEAR TO INVOLVE ONLY ONSHORE-OFFSHORE TRANSPORT OF SAND GRAINS. A BREAKER-HEIGHT GRADIENT OCCURS ALONG THE BEACH, SO THAT TWO BEACH PROFILES WERE ESTABLISHED. GRADIENTS ALSO OCCUR ALONG THE BEACH IN SAND TEXTURE, BEACH SLOPE, AND BEACH CURVATURE. THE TWO PROFILES, RESTRICTED TO THE INTERTIDAL ZONE, WERE MEASURED QUASI-WEEKLY AND THEN DAILY OVER A PERIOD OF NINE MONTHS. THE CHANGES IN SAND LEVEL AT BOTH WERE QUITE SIMILAR IN MAGNITUDE IN SPITE OF THE WAVE HEIGHT GRADIENT ALONG THE BEACH. NO CLEAR-CUT SEASONAL CYCLE AND NO FORTNIGHTLY SPRING-NEAP TIDAL CYCLE WAS DETECTED IN THE DATA. THE CONCURRENT NATURE OF THE DAILY VARIATIONS OF BOTH SAND LEVEL AND WAVES RECORDED IMMEDIATELY OFF THE BEACH LEAVE NO DOUBT THAT CHANGING WAVE CONDITIONS WERE THE PRIMARY CAUSE OF THE CHANGES OBSERVED IN DEL MONTE BEACH, EVEN THOUGH NO CLEAR-CUT RELATIONSHIP BETWEEN THE TWO FACTORS WAS APPARENT. (SINHA - OEIS) JF - IN: PROCEEDINGS OF NINTH CONFERENCE ON COASTAL ENGINEERING, LISBON, PORTUGAL, JUNE 1964, AMERICAN SOCIETY OF CIVIL ENGINEERS, CHAP 16, P 249-258, 1964. 4 FIG, 9 REF. AU - Rohrbough, J D AU - KOEHR, JE AU - Thompson, W C AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1964/06// PY - 1964 DA - Jun 1964 KW - Water Resources Abstracts KW - *CALIFORNIA KW - *BEACHES KW - *REFRACTION(WATER WAVES) KW - *SEDIMENT TRANSPORT KW - *BAYS KW - *SHALLOW WATER KW - PROFILES KW - INTERTIDAL AREAS KW - COASTS KW - *MONTEREY BAY(CALIF) KW - NEARSHORE PROCESSES KW - ONSHORE-OFFSHORE TRANSPORT KW - DAILY VARIATIONS KW - SW 0870:Erosion and sedimentation KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19086713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=QUASI-WEEKLY+AND+DAILY+PROFILE+CHANGES+ON+A+DISTINCTIVE+SAND+BEACH&rft.au=Rohrbough%2C+J+D%3BKOEHR%2C+JE%3BThompson%2C+W+C&rft.aulast=Rohrbough&rft.aufirst=J&rft.date=1964-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - STORMS CAUSING HARBOR AND SHORELINE DAMAGE THROUGH WIND AND WAVES NEAR MONTEREY, CALIFORNIA AN - 19086728; 7404208 AB - TO GAIN INFORMATION THAT MIGHT LEAD TO FORECASTING TECHNIQUES, A COMPLETE LIST OF STORMS FOR THE 50-YEAR PERIOD FROM 1910 TO 1960 WAS MADE THROUGH A SEARCH OF LOCAL NEWSPAPER FILES. THE MOST SIGNIFICANT STORMS, THEIR FREQUENCY OF OCCURRENCE, THE SYNOPTIC SITUATIONS WITH WHICH THEY WERE ASSOCIATED, AND THE HINDCASTED SEA CONDITION THAT ACCOMPANIED THEM ARE DESCRIBED. TWO GENERAL TYPES OF DAMAGING STORMS WERE FOUND TO EXIST: ONE OCCURRING OFFSHORE IN THE OPEN OCEAN AND CAUSING SHORELINE EROSION AND FLOODING BY THE ACTION OF SEA AND SWELL; THE OTHER, A LOCAL WINDSTORM SWEEPING ACROSS MONTEREY BAY AND CAUSING DAMAGE TO VESSELS IN THE HARBOR MAINLY BY THE COMBINED EFFECTS OF STRONG GUSTY WINDS AND SHORT-PERIOD SEAS GENERATED IN THE BAY. WAVE HINDCASTS WERE MADE TO FACILITATE COMPARISONS OF STORM INTENSITIES WITHIN EACH OF THE TWO TYPES OF STORMS. THESE COMPARISONS, IN TERMS OF THE INTENSITY OF WAVE CONDITIONS, WERE MADE USING A QUANTITY CALLED DAMAGE POTENTIAL, A FUNCTION OF THE SIZE AND DURATION OF THE STORM WAVES. SYNOPTIC SITUATIONS WITH WHICH THESE STORMS WERE ASSOCIATED WERE CLASSIFIED BY A WEATHER-TYPING SYSTEM. ALL STORMS WERE FOUND TO BE ASSOCIATED WITH ONE OF THREE PRINCIPAL TYPES. THE POSSIBILITY OF AN OBJECTIVE-TYPE FORECASTING TECHNIQUE FOR THE WIND-STORMS IS DISCUSSED. (SINHA-OEIS) JF - AVAILABLE FROM NTIS AS AD-619 505, FOR $6.00 PAPER COPY, $1.45 MICROFICHE. MS THESIS, 1962. 179 P, 85 FIG, 4 TAB, 16 REF, 5 APPEND. AU - Bixby, H L AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF Y1 - 1962 PY - 1962 DA - 1962 KW - Water Resources Abstracts KW - *CALIFORNIA KW - *STORMS KW - *HARBORS KW - *WEATHER FORECASTING KW - *METEOROLOGICAL DATA KW - *WAVES(WATER) KW - FLOODING KW - DAMAGES KW - WINDS KW - SHORES KW - SYNOPTIC ANALYSIS KW - BEACH EROSION KW - *WINDSTORMS KW - MONTEREY(CA) KW - SEAS KW - SWELL KW - SW 0870:Erosion and sedimentation KW - SW 0815:Precipitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19086728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=STORMS+CAUSING+HARBOR+AND+SHORELINE+DAMAGE+THROUGH+WIND+AND+WAVES+NEAR+MONTEREY%2C+CALIFORNIA&rft.au=Bixby%2C+H+L&rft.aulast=Bixby&rft.aufirst=H&rft.date=1962-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Recent Publication AN - 1298508888 JF - The North Dakota Quarterly Y1 - 1956///Summer PY - 1956 DA - Summer 1956 CY - Grand Forks, N. Dak PB - University of North Dakota. VL - 24 IS - 3 SN - 0029-277X KW - History (The Americas) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1298508888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apio&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+North+Dakota+Quarterly&rft.atitle=Recent+Publication&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1956-07-01&rft.volume=24&rft.issue=3&rft.spage=Inside+Back+Cover&rft.isbn=&rft.btitle=&rft.title=The+North+Dakota+Quarterly&rft.issn=0029277X&rft_id=info:doi/ DB - Periodicals Index Online N1 - Last updated - 2013-02-23 ER - TY - JOUR T1 - Pathogenesis of Escherichia coli O157:H7 strain 86-24 following oral infection of BALB/c mice with an intact commensal flora AN - 746074187; 13022737 AB - Escherichia coli O157:H7 is a food-borne pathogen that can cause hemorrhagic colitis and, occasionally, hemolytic uremic syndrome, a sequela of infection that can result in renal failure and death. Here we sought to model the pathogenesis of orally-administered E. coli O157:H7 in BALB/c mice with an intact intestinal flora. First, we defined the optimal dose that permitted sustained fecal shedding of E. coli O157:H7 over 7 days (a14109 colony forming units). Next, we monitored the load of E. coli O157:H7 in intestinal sections over time and observed that the cecum was consistently the tissue with the highest E.aacoli O157:H7 recovery. We then followed the expression of two key E. coli O157:H7 virulence factors, the adhesin intimin and Shiga toxin type 2, and detected both proteins early in infection when bacterial burdens were highest. Additionally, we noted that during infection, animals lost weight and a1430% died. Moribund animals also exhibited elevated levels of blood urea nitrogen, and, on necropsy, showed evidence of renal tubular damage. We conclude that conventional mice inoculated orally with high doses of E. coli O157:H7 can be used to model both intestinal colonization and subsequent development of certain extraintestinal manifestations of E. coli O157:H7 disease. JF - Microbial Pathogenesis AU - Mohawk, Krystle L AU - Melton-Celsa, Angela R AU - Zangari, Tonia AU - Carroll, Erica E AU - O'Brien, Alison D AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA SP - 131 EP - 142 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 48 IS - 3-4 SN - 0882-4010, 0882-4010 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Escherichia coli O157:H7 mouse model KW - Shiga toxin KW - intimin KW - Autopsy KW - Adhesins KW - virulence factors KW - Food KW - Animal models KW - Commensals KW - Urea KW - Hemorrhage KW - Colonization KW - Colonies KW - Hemolytic uremic syndrome KW - Escherichia coli KW - Cecum KW - Renal failure KW - Pathogens KW - Intestinal microflora KW - Blood KW - Kidney KW - Intestine KW - Oral infection KW - Colitis KW - Intimin KW - Nitrogen KW - A 01310:Products of Microorganisms KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746074187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Pathogenesis+of+Escherichia+coli+O157%3AH7+strain+86-24+following+oral+infection+of+BALB%2Fc+mice+with+an+intact+commensal+flora&rft.au=Mohawk%2C+Krystle+L%3BMelton-Celsa%2C+Angela+R%3BZangari%2C+Tonia%3BCarroll%2C+Erica+E%3BO%27Brien%2C+Alison+D&rft.aulast=Mohawk&rft.aufirst=Krystle&rft.date=&rft.volume=48&rft.issue=3-4&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2010.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Adhesins; Autopsy; virulence factors; Food; Commensals; Animal models; Renal failure; Urea; Pathogens; Hemorrhage; Blood; Intestinal microflora; Colonization; Colonies; Hemolytic uremic syndrome; Intestine; Kidney; Cecum; Oral infection; Colitis; Shiga toxin; Intimin; Nitrogen; Escherichia coli DO - http://dx.doi.org/10.1016/j.micpath.2010.01.003 ER - TY - JOUR T1 - Central Serous Chorioretinopathy Resulting in Altered Vision and Color Perception After Glenohumeral Corticosteroid Injection AN - 20974424; 11054452 AB - Complications from shoulder corticosteroid injections are uncommon. This article presents a case of altered color perception and visual disturbances in a 29-year-old male active duty Navy SEAL following an intra-articular glenohumeral corticosteroid injection, previously unreported in the orthopedic literature. The corticosteroid injection was administered for the treatment of right-shoulder stiffness occurring approximately 3 months following an arthroscopic superior labrum anterior-posterior (SLAP) repair and subacromial decompression of the ipsilateral shoulder. The patient experienced immediate relief after the injection. Seven days later, however, he began to notice visual disturbances with color and image distortion of his right eye. He also developed a papular, nonpruritic rash on his upper trunk that eventually extended down his legs. He was diagnosed by an ophthalmologist as having central serous chorioretinopathy, a condition in which serous fluid accumulates in the subretinal space of the eye, causing detachment of the retina from the underlying retinal pigment epithelium. The reaction spontaneously resolved within approximately 10 to 12 weeks without treatment. Although intra-articular corticosteroid injections are frequently performed with a low rate of complication, clinicians should be familiar with this rare yet distressing condition. Furthermore, patients with increased production of endogenous corticosteroids (eg, those with Cushing's syndrome, type A personality, hypertension, or obstructive sleep apnea) should be warned of the potential of chorioretinopathy after an intra-articular corticosteroid injection. JF - Orthopedics AU - Hurvitz AU - Hodapp, K L AU - Jadgchew, J AU - Solomon, D J AU - Provencher, M T AU - Stolldorf, H S AD - Uniformed Services, University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA SP - 600 SN - 0147-7447, 0147-7447 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Decompression KW - Color vision KW - Sleep disorders KW - Eye KW - Retina KW - Apnea KW - Orthopedics KW - Personality KW - Cushing's syndrome KW - Image processing KW - Leg KW - Exanthema KW - retinal pigment epithelium KW - Corticoids KW - Perception KW - Visual perception KW - Vision KW - Sleep KW - Shoulder KW - Navy KW - Labrum KW - Hypertension KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20974424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Orthopedics&rft.atitle=Central+Serous+Chorioretinopathy+Resulting+in+Altered+Vision+and+Color+Perception+After+Glenohumeral+Corticosteroid+Injection&rft.au=Hurvitz%3BHodapp%2C+K+L%3BJadgchew%2C+J%3BSolomon%2C+D+J%3BProvencher%2C+M+T%3BStolldorf%2C+H+S&rft.aulast=Hurvitz&rft.aufirst=&rft.date=&rft.volume=&rft.issue=&rft.spage=600&rft.isbn=&rft.btitle=&rft.title=Orthopedics&rft.issn=01477447&rft_id=info:doi/10.3928%2F01477447-20090624-22 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Color vision; Decompression; Retina; Eye; Sleep disorders; Apnea; Orthopedics; Cushing's syndrome; Personality; Image processing; Leg; Corticoids; retinal pigment epithelium; Exanthema; Vision; Visual perception; Perception; Shoulder; Sleep; Navy; Labrum; Hypertension DO - http://dx.doi.org/10.3928/01477447-20090624-22 ER - TY - JOUR T1 - The effect of xenobiotic exposure on spontaneous autoimmunity in (SWR X SJL)F1 hybrid mice AN - 20920189; 6757335 AB - F1 hybrids of SWR (H-2 super(q)) and SJL (H-2 super(S)) mice spontaneously develop a lupuslike condition in an age-dependent manner, and these two H-2 haplotypes also confer susceptibility to induction of systemic autoimmunity by heavy metals such as mercury, silver, and gold with antifibrillarin antibodies (AFA) as marker. The aim of this study was to determine how the mixing of two susceptible genomes might influence expression of idiopathic and induced autoimmunity over a period of 14 mo of exposure to mercury and silver. Spontaneous autoimmunity first appeared as antinuclear antibodies (ANA) in females at 70 wk of age and in males at 10 mo of age, and was followed by development of anti-chromatin antibodies. Antibodies to double-stranded DNA developed in 60% of males and 20% of females. Thirty percent of males and 10% of females developed a coarsely speckled ANA pattern associated with high titers of anti-Sm antibodies. Glomerular immune complex (IC) deposits and a proliferative glomerulonephritis were seen at 17 mo of age. The F1 hybrids treated with metals showed no exaggeration of spontaneous autoimmunity. However, the metals suppressed the spontaneous development of anti-Sm and antichromatin antibodies. The metal-induced AFA, linked to the H-2 super(s) and H-2 super(q) haplotype, reached a maximum after 3-4 mo of treatment and then declined; 33% of the silver-treated hybrids finally became AFA-negative, despite continuous treatment The decline in ANoA during metal treatment is contrary to the situation in metal-treated SJL mice. This indicates that dominant SWR background genes suppressed induction of certain autoimmune traits in the (SWR x S]L)F1 hybrid mice. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Hultman, P AU - Taylor, A AU - Yang, J M AU - Pollard, K M AD - Div. Mol. Immunol, Pathology (AIR), University Hospital, SE-581 85 Linkoping, Sweden, perhu@imk.liu.se SP - 505 EP - 523 VL - 69 IS - 5-6 SN - 1528-7394, 1528-7394 KW - Toxicology Abstracts KW - Genomes KW - Metals KW - Antinuclear antibodies KW - Glomerulonephritis KW - Heavy metals KW - Antigen-antibody complexes KW - Autoimmunity KW - Xenobiotics KW - Haplotypes KW - Hybrids KW - DNA KW - Gold KW - Mercury KW - Histocompatibility antigen H-2 KW - Silver KW - X 24165:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20920189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=The+effect+of+xenobiotic+exposure+on+spontaneous+autoimmunity+in+%28SWR+X+SJL%29F1+hybrid+mice&rft.au=Hultman%2C+P%3BTaylor%2C+A%3BYang%2C+J+M%3BPollard%2C+K+M&rft.aulast=Hultman&rft.aufirst=P&rft.date=&rft.volume=69&rft.issue=5-6&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390500354904 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Antinuclear antibodies; Metals; Glomerulonephritis; Heavy metals; Antigen-antibody complexes; Autoimmunity; Xenobiotics; Haplotypes; Hybrids; DNA; Mercury; Gold; Histocompatibility antigen H-2; Silver DO - http://dx.doi.org/10.1080/15287390500354904 ER - TY - JOUR T1 - Energetics of Breaking Waves Within the Surf Zone AN - 19218311; 8000737 AB - Surface elevations and velocities were measured for a variety of breaking wave conditions including collapsing, plunging, and spilling breakers. Turbulent and wave-induced velocity components were separated by associating the wave-induced velocities with contribution coherent with the surface. Most of the measurements were made in the lower half of the water column and are indicative of conditions in this region. The average velocity intensity for all experiments was 85% wave induced, indicating that the kinetic energy is primarily wave induced. Remarkably little difference was found between collapsing, plunging, and spilling breakers in terms of percent wave-induced velocity intensity. Breaking waves can be characterized as highly nonlinear with strong wave-wave interactions resulting in energy being transferred away from the primary wave frequency, resulting in a saturation region at higher frequencies. Similarity arguments assuming kinematic instability with phase speed the only relevent parameter suggest a -3 slope for the log-log frequency spectrum of both the surface and horizontal velocities in shallow water. The surface elevation spectra of collapsing and plunging breakers have a slope more closely approximated by a -7/3 slope, indicating the possible importance of surface tension in the breaking processes; the velocity spectra show a -3 slope. The saturation region for spilling breakers surface elevation spectra varied from -3 at lower frequencies to -5 at highest frequencies. (Sims-ISWS) JF - NR388-114. AU - Thornton, E B AD - Naval Postgraduate School Monterey, CA. Dept. of Oceanography KW - Water Resources Abstracts KW - Waves(Water) KW - Ocean waves KW - Coasts KW - Beaches KW - Measurement KW - On-site investigations KW - Data processing KW - Turbulence KW - Energy KW - Velocity KW - Surf KW - Breaking waves KW - SW 0890:Estuaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19218311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Energetics+of+Breaking+Waves+Within+the+Surf+Zone&rft.au=Thornton%2C+E+B&rft.aulast=Thornton&rft.aufirst=E&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - AN EVALUATION OF A NUMERICAL WATER ELEVATION AND TIDAL CURRENT PREDICTION MODEL APPLIED TO MONTEREY BAY AN - 19017589; 7110988 AB - THE HANSEN HYDRODYNAMICAL - NUMERICAL MODEL WAS EVALUATED FOR MONTEREY BAY WITH ACTUAL FIELD DATA. TIDES AND WINDS ARE THE PRINCIPAL DRIVING FORCES OF THE HANSEN MODEL. ANALYSIS OF THE FIELD DATA INDICATED THAT THE PRINCIPAL DRIVING FORCE OF THE CIRCULATION IN THE BAY WAS THE OCEANIC CURRENTS AND NOT THE TIDES AND WINDS. THE TIDAL HEIGHTS AND PHASES AND CURRENT DIRECTIONS WERE CALCULATED CORRECTLY BY THE MODEL, BUT THE CALCULATED CURRENT SPEEDS WERE AN ORDER OF MAGNITUDE TOO LARGE. THE INACCURACY OF THE CURRENT SPEEDS WAS ATTRIBUTED TO THE INACCURATE CALCULATIONS OF THE CURRENTS ALONG THE OPEN BOUNDARY AND THE LARGE BATHYMETRIC GRADIENTS OF THE MONTEREY SUBMARINE CANYON. JF - AVAILABLE FROM THE NATIONAL TECHNICAL INFORMATION SERVICE AS AD-722 562, $3.00 IN PAPER COPY, $0.95 IN MICROFICHE. AU - MARK LAZANOFF, SHELDON AD - NAVAL POSTGRADUATE SCHOOL, MONTEREY, CALIF KW - Water Resources Abstracts KW - *TIDES KW - *MATHEMATICAL MODELS KW - *FORECASTING KW - *HYDRODYNAMICS KW - OCEAN CURRENTS KW - BAYS KW - BATHYTHERMOGRAPHS KW - WIND KW - VELOCITY KW - MATHEMATICAL PREDICTION KW - OCEAN BOTTOM KW - CALIFORNIA KW - BATHYTHERMOGRAPH DATA KW - MONTEREY BAY KW - SUBMARINE CANYONS KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19017589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=AN+EVALUATION+OF+A+NUMERICAL+WATER+ELEVATION+AND+TIDAL+CURRENT+PREDICTION+MODEL+APPLIED+TO+MONTEREY+BAY&rft.au=MARK+LAZANOFF%2C+SHELDON&rft.aulast=MARK+LAZANOFF&rft.aufirst=SHELDON&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Nondestructive inspection using Compton scatter tomography AN - 17099654; 4403400 AB - A method for non-invasively generating tomographic images of electron density in materials using Compton scattered gamma rays is investigated. Electron density is an indicator of density or composition changes in a material. In Compton scatter tomography, the energy distribution of monoenergetic gamma rays is measured after scattering from a material target. Measuring a scattered gamma ray's energy localizes the scattering position to a definable region of the sample. We develop an analytic computational model to study the image quality of a realistic system. In particular, the deleterious effects of finite source and detector size, Compton broadening, and Poisson noise are investigated. A backprojection algorithm is presented to demonstrate the impact of these effects on image reconstruction and contrast recovery. Detection of corrosion in low-Z materials is an application of interest, and is used to study the Compton scatter tomography technique. JF - IEEE Transactions on Nuclear Science AU - Evans, B L AU - Martin, J B AU - Burggraf, L W AU - Roggemann, M C AD - Air Force Institute of Technology, Department of Engineering Physics, 2950 P St., Wright-Patterson AFB, OH 45433, USA SP - 950 EP - 955 VL - 45 IS - 3 SN - 0018-9499, 0018-9499 KW - electron density KW - nondestructive testing KW - Health & Safety Science Abstracts KW - Materials testing KW - Corrosion KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17099654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Nuclear+Science&rft.atitle=Nondestructive+inspection+using+Compton+scatter+tomography&rft.au=Evans%2C+B+L%3BMartin%2C+J+B%3BBurggraf%2C+L+W%3BRoggemann%2C+M+C&rft.aulast=Evans&rft.aufirst=B&rft.date=&rft.volume=45&rft.issue=3&rft.spage=950&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Nuclear+Science&rft.issn=00189499&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Corrosion; Materials testing ER - TY - CPAPER T1 - Identifying Intersections of Dispersion Curves for Phononic Crystals T2 - 2013 International Mechanical Engineering Congress & Exposition (ASME 2013) AN - 1504730959; 6270124 JF - 2013 International Mechanical Engineering Congress & Exposition (ASME 2013) AU - Liu, Kuo-Chung AU - Chou, Yuan-fang KW - Dispersion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504730959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2013+International+Mechanical+Engineering+Congress+%26+Exposition+%28ASME+2013%29&rft.atitle=Identifying+Intersections+of+Dispersion+Curves+for+Phononic+Crystals&rft.au=Liu%2C+Kuo-Chung%3BChou%2C+Yuan-fang&rft.aulast=Liu&rft.aufirst=Kuo-Chung&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2013+International+Mechanical+Engineering+Congress+%26+Exposition+%28ASME+2013%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asmeconferences.org/Congress2013//pdfs/FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-28 N1 - Last updated - 2014-03-07 ER - TY - CPAPER T1 - Inflammatory monocytes are critical for induction of a polysaccharide-specific antibody response to an intact bacterium T2 - 100th Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2013) AN - 1504727134; 6265445 JF - 100th Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2013) AU - Chen, Quanyi AU - Snapper, Clifford KW - Antibodies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504727134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2013%29&rft.atitle=Inflammatory+monocytes+are+critical+for+induction+of+a+polysaccharide-specific+antibody+response+to+an+intact+bacterium&rft.au=Chen%2C+Quanyi%3BSnapper%2C+Clifford&rft.aulast=Chen&rft.aufirst=Quanyi&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2013%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jimmunol.org/content/vol190/1ULMeetingAbstracts LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-28 N1 - Last updated - 2014-03-07 ER - TY - CPAPER T1 - Non-covalent association of protein and capsular polysaccharide on bacteria-sized latex beads as a model for polysaccharide-specific humoral immunity to intact Gram-positive extracellular bacteria T2 - 100th Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2013) AN - 1504727037; 6265431 JF - 100th Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2013) AU - Colino, Jesus AU - Duke, Leah AU - Snapper, Clifford KW - Latex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504727037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2013%29&rft.atitle=Non-covalent+association+of+protein+and+capsular+polysaccharide+on+bacteria-sized+latex+beads+as+a+model+for+polysaccharide-specific+humoral+immunity+to+intact+Gram-positive+extracellular+bacteria&rft.au=Colino%2C+Jesus%3BDuke%2C+Leah%3BSnapper%2C+Clifford&rft.aulast=Colino&rft.aufirst=Jesus&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2013%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jimmunol.org/content/vol190/1ULMeetingAbstracts LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-28 N1 - Last updated - 2014-03-07 ER - TY - CPAPER T1 - Experimental and Computational Investigation of the Drag of a Towed Hydropower Turbine T2 - 2013 International Mechanical Engineering Congress & Exposition (ASME 2013) AN - 1504726677; 6268591 JF - 2013 International Mechanical Engineering Congress & Exposition (ASME 2013) AU - Bryan, Grant AU - Platzer, Max AU - Kwon, Young KW - Hydroelectric power UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504726677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2013+International+Mechanical+Engineering+Congress+%26+Exposition+%28ASME+2013%29&rft.atitle=Experimental+and+Computational+Investigation+of+the+Drag+of+a+Towed+Hydropower+Turbine&rft.au=Bryan%2C+Grant%3BPlatzer%2C+Max%3BKwon%2C+Young&rft.aulast=Bryan&rft.aufirst=Grant&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2013+International+Mechanical+Engineering+Congress+%26+Exposition+%28ASME+2013%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asmeconferences.org/Congress2013//pdfs/FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-28 N1 - Last updated - 2014-03-07 ER - TY - CPAPER T1 - Guaranteed Cost Control of Uncertain Discrete-Time System Subjected to Actuator Saturation via Homogenous Polynomial Lyapunov Function T2 - 2013 International Mechanical Engineering Congress & Exposition (ASME 2013) AN - 1504725668; 6268194 JF - 2013 International Mechanical Engineering Congress & Exposition (ASME 2013) AU - Arshad, S M AU - Khan, Muhammad AU - Mazhar, Kamal KW - Mechanical engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504725668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2013+International+Mechanical+Engineering+Congress+%26+Exposition+%28ASME+2013%29&rft.atitle=Guaranteed+Cost+Control+of+Uncertain+Discrete-Time+System+Subjected+to+Actuator+Saturation+via+Homogenous+Polynomial+Lyapunov+Function&rft.au=Arshad%2C+S+M%3BKhan%2C+Muhammad%3BMazhar%2C+Kamal&rft.aulast=Arshad&rft.aufirst=S&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2013+International+Mechanical+Engineering+Congress+%26+Exposition+%28ASME+2013%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asmeconferences.org/Congress2013//pdfs/FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-28 N1 - Last updated - 2014-03-07 ER -