TY - JOUR
T1 - Kappa Opioid receptor ligands regulate angiogenesis in development and in tumours
AN - 1837294725; 21214314
AB - Opioid systems mainly regulate physiological functions such as pain, emotional tone and reward circuitry in neural tissues (brain and spinal cord). These systems are also found in extraneural tissues (ganglia, gut, spleen, stomach, lung, pancreas, liver, heart, blood and blood vessels), and recent studies have elucidated their roles in various organs. The current review focuses on the roles of opioid systems in blood vessels, especially angiogenesis, during development and tumour malignancy. The balance between endogenous activators and inhibitors of angiogenesis delicately maintains a normally quiescent vasculature to sustain homeostasis. Disturbance of this balance causes pathogenic angiogenesis and, especially in tumours, several activators such as VEGF are highly expressed in the tumour microenvironment and strongly induce tumour angiogenesis, the so-called angiogenic switch. Recently, we demonstrated that Kappa opioid receptor agonists function as anti-angiogenic factors, which impede the angiogenic switch, in vascular development and tumour angiogenesis by inhibiting the expression of receptors for VEGF. In clinical medicine, angiogenesis inhibitors that target VEGF signalling such as bevacizumab are used as anti-cancer drugs. Although therapies that inhibit tumour angiogenesis have been highly successful for tumour therapy, most patients eventually develop resistance to this anti-angiogenic therapy. Thus, we must identify novel targets for anti-angiogenic agents to sustain inhibition of angiogenesis for tumour therapy. The regulation of responses to Kappa opioid receptor ligands could be useful for controlling vascular formation under physiological conditions and in cancers, and thus could offer therapeutic benefits beyond the relief of pain. Linked Articles This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2
JF - British Journal of Pharmacology
AU - Yamamizu, Kohei
AU - Hamada, Yusuke
AU - Narita, Minoru
AD - Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 268
EP - 276
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 172
IS - 2
SN - 0007-1188, 0007-1188
KW - Toxicology Abstracts
KW - Vascular endothelial growth factor
KW - Opioid receptors
KW - Heart
KW - Receptor mechanisms
KW - Spinal cord
KW - Pancreas
KW - angiogenesis inhibitors
KW - Angiogenesis
KW - Spleen
KW - Pain
KW - Tumors
KW - Homeostasis
KW - Bevacizumab
KW - Digestive tract
KW - Blood vessels
KW - Lung
KW - Reinforcement
KW - Ganglia
KW - Signal transduction
KW - X 24380:Social Poisons & Drug Abuse
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837294725?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Pharmacology&rft.atitle=Kappa+Opioid+receptor+ligands+regulate+angiogenesis+in+development+and+in+tumours&rft.au=Yamamizu%2C+Kohei%3BHamada%2C+Yusuke%3BNarita%2C+Minoru&rft.aulast=Yamamizu&rft.aufirst=Kohei&rft.date=2015-01-01&rft.volume=172&rft.issue=2&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Pharmacology&rft.issn=00071188&rft_id=info:doi/10.1111%2Fbph.12573
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-11-01
N1 - Last updated - 2016-12-22
N1 - SubjectsTermNotLitGenreText - Heart; Opioid receptors; Vascular endothelial growth factor; Receptor mechanisms; Spinal cord; angiogenesis inhibitors; Pancreas; Angiogenesis; Spleen; Pain; Bevacizumab; Homeostasis; Tumors; Digestive tract; Blood vessels; Lung; Reinforcement; Ganglia; Signal transduction
DO - http://dx.doi.org/10.1111/bph.12573
ER -
TY - JOUR
T1 - Expression signature of microRNA-155 in hepatitis C virus genotype 4 infection.
AN - 1826606642; 25469255
AB - Hepatits C virus (HCV) genotype 4 (GT4) shows low treatment response rates and discrepancies when compared to other genotypes. However, the reason underlying these discrepancies remains unclear due to the limited number of studies on GT4. microRNA-155 (miR-155) is a noteworthy example of a discrepancy in GT4, as it was found to be upregulated in genotypes 1, 2 and 3 HCV infection, but downregulated in GT4-HCV-infected peripheral blood mononuclear cells (PBMCs). The present study aimed to investigate the expression of miR-155 in PBMCs, serum and liver tissues of GT4-HCV-infected patients. miR-155 expression was assessed using reverse transcription-quantitative polymerase chain reaction in GT4-HCV-infected PBMCs, serum and liver tissues, as well as GT2- and GT4-infected Huh7 cells, and compared to the healthy controls. There was no difference in miR-155 expression observed between naïve GT4-HCV patients and healthy controls in the PBMCs and serum. In HCV-infected liver tissues, however, a significant downregulation was observed. The unique miR-155 expression pattern during GT4 infection was confirmed in the infected Huh7 cell lines when compared to GT2 infection. Clinical data showed a positive correlation between liver transaminases and serum miR-155 expression. In addition, serum miR-155 expression was significantly lower in naïve non-responders (NRs) than naïve sustained virological responders (SVRs), and in post-treatment NRs compared to post-treatment SVRs. In conclusion, miR-155 was not only proven to be a genotype-specific microRNA that is not induced during GT4-HCV infection, but also a good prognostic factor and predictor of response to treatment enabling a non-invasive differentiation between NRs and SVRs during GT4-HCV infection.
JF - Biomedical reports
AU - Riad, Sarah Ehab
AU - El-Ekiaby, Nada
AU - Mekky, Radwa Yehia
AU - Ahmed, Rasha
AU - El Din, Mohammad Ahmed Mohey
AU - El-Sayed, Mohammad
AU - Abouelkhair, Mahmoud Mohammad
AU - Salah, Ayman
AU - Zekri, Abdel Rahman
AU - Esmat, Gamal
AU - Abdelaziz, Ahmed Ihab
AD - The Molecular Pathology Research Group, Department of Pharmacology and Toxicology, German University in Cairo, New Cairo 11835, Egypt. ; Departments of Endemic Medicine and Hepatology and Egypt. ; Departments of Surgery, Cairo University, Cairo 11562, Egypt. ; Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11976, Egypt.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 93
EP - 97
VL - 3
IS - 1
SN - 2049-9434, 2049-9434
KW - microRNA-155
KW - genotype 4
KW - treatment response
KW - hepatitis C virus
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826606642?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+reports&rft.atitle=Expression+signature+of+microRNA-155+in+hepatitis+C+virus+genotype+4+infection.&rft.au=Riad%2C+Sarah+Ehab%3BEl-Ekiaby%2C+Nada%3BMekky%2C+Radwa+Yehia%3BAhmed%2C+Rasha%3BEl+Din%2C+Mohammad+Ahmed+Mohey%3BEl-Sayed%2C+Mohammad%3BAbouelkhair%2C+Mahmoud+Mohammad%3BSalah%2C+Ayman%3BZekri%2C+Abdel+Rahman%3BEsmat%2C+Gamal%3BAbdelaziz%2C+Ahmed+Ihab&rft.aulast=Riad&rft.aufirst=Sarah&rft.date=2015-01-01&rft.volume=3&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Biomedical+reports&rft.issn=20499434&rft_id=info:doi/
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date created - 2014-12-03
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
ER -
TY - JOUR
T1 - Short food safety videos promote peer networking and behavior change
AN - 1815699833; PQ0003312906
AB - Purpose - The purpose of this paper is to create a series of 30-60-second short videos to promote improved food safety behaviors of middle school youth, determine the feasibility of disseminating the videos through peer networks, and measure their effects on food safety attitudes, perceived social norms, and behaviors of youth. Design/methodology/approach - Food safety content specialists, learning experts, programmers, illustrators, project managers, instructional designers, scriptwriters, and stakeholders were involved in creation of the Don't Be Gross short videos before evaluation by middle school youth (sixth to eighth grades). The experimental group ( n =220) completed the following activities at about one-week intervals: pre-test, viewed videos, post-test, and follow-up test. The control group ( n =112) completed the same activities at similar intervals but did not have access to the videos until after the follow-up test. Findings - Controlling for grade and gender, linear mixed-effects models revealed significant time by group effects for participants' perceived susceptibility to foodborne illness; intentions to perform recommended food safety behaviors approached significance. Additionally, compared to the pre-test, the experimental group perceived their friends as being significantly more confident in performing food safety behaviors at post- and follow-up tests. Google Analytics data revealed that the bounce rate from the home page of the videos was low (38 percent) suggesting that the videos were engaging. Originality/value - The Don't Be Gross videos were liked by youth and shared among their peers and may have the potential to promote positive food safety behaviors and intentions among youth.
JF - British Food Journal
AU - Quick, Virginia
AU - Corda, Kirsten W
AU - Martin-Biggers, Jennifer
AU - Chamberlin, Barbara
AU - Schaffner, Donald W
AU - Byrd-Bredbenner, Carol
AD - Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development/ National Institutes of Health, Bethesda, Maryland, USA
Y1 - 2015///0,
PY - 2015
DA - 0, 2015
SP - 78
EP - 93
PB - Emerald Group Publishing Limited, 60-62 Toller Lane Bradford West Yorkshire BD8 9BY United Kingdom
VL - 117
IS - 1
SN - 0007-070X, 0007-070X
KW - Biotechnology and Bioengineering Abstracts
KW - Food safety
KW - Youth
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815699833?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Food+Journal&rft.atitle=Short+food+safety+videos+promote+peer+networking+and+behavior+change&rft.au=Quick%2C+Virginia%3BCorda%2C+Kirsten+W%3BMartin-Biggers%2C+Jennifer%3BChamberlin%2C+Barbara%3BSchaffner%2C+Donald+W%3BByrd-Bredbenner%2C+Carol&rft.aulast=Quick&rft.aufirst=Virginia&rft.date=2015-01-01&rft.volume=117&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=British+Food+Journal&rft.issn=0007070X&rft_id=info:doi/
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-08-01
N1 - Number of references - 55
N1 - Last updated - 2016-09-01
ER -
TY - JOUR
T1 - Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice
AN - 1758247233; PQ0002448370
AB - The role of scavenger receptor class B, type I (SR-BI) in endothelial cells (EC) was examined in several novel transgenic mouse models expressing SR-BI in endothelium of mice with normal C57Bl6/N, apoE-KO, or Scarb1 -KO backgrounds. Mice were also created expressing SR-BI exclusively in endothelium and liver. Endothelial expression of the Tie2-Scarb1 transgene had no significant effect on plasma lipoprotein levels in mice on a normal chow diet but on an atherogenic diet, significantly decreased plasma cholesterol levels, increased plasma HDL cholesterol (HDL-C) levels, and protected mice against atherosclerosis. In 8-month-old apoE-KO mice fed a normal chow diet, the Tie2-Scarb1 transgene decreased aortic lesions by 24%. Mice expressing SR-BI only in EC and liver had a 1.5 plus or minus 0.1-fold increase in plasma cholesterol compared to mice synthesizing SR-BI only in liver. This elevation was due mostly to increased HDL-C. In EC culture studies, SR-BI was found to be present in both basolateral and apical membranes but greater cellular uptake of cholesterol from HDL was found in the basolateral compartment. In summary, enhanced expression of SR-BI in EC resulted in a less atherogenic lipoprotein profile and decreased atherosclerosis, suggesting a possible role for endothelial SR-BI in the flux of cholesterol across EC.
JF - BioMed Research International
AU - Vaisman, Boris L
AU - Vishnyakova, Tatyana G
AU - Freeman, Lita A
AU - Amar, Marcelo J
AU - Demosky, Stephen J
AU - Liu, Chengyu
AU - Stonik, John A
AU - Sampson, Maureen L
AU - Pryor, Milton
AU - Bocharov, Alexander V
AU - Eggerman, Thomas L
AU - Patterson, Amy P
AU - Remaley, Alan T
AD - Lipoprotein Metabolism Section, Cardiovascular-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA, borisv@mail.nih.gov
Y1 - 2015/01//
PY - 2015
DA - January 2015
PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States
VL - 2015
SN - 2314-6133, 2314-6133
KW - Biotechnology and Bioengineering Abstracts
KW - Diets
KW - Atherogenic diet
KW - Aorta
KW - Transgenes
KW - Lipoproteins (high density)
KW - Animal models
KW - Cell culture
KW - Arteriosclerosis
KW - Cholesterol
KW - Transgenic mice
KW - Endothelial cells
KW - Endothelium
KW - Lipoproteins
KW - Liver
KW - scavenger receptors
KW - W 30925:Genetic Engineering
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758247233?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Endothelial+Expression+of+Scavenger+Receptor+Class+B%2C+Type+I+Protects+against+Development+of+Atherosclerosis+in+Mice&rft.au=Vaisman%2C+Boris+L%3BVishnyakova%2C+Tatyana+G%3BFreeman%2C+Lita+A%3BAmar%2C+Marcelo+J%3BDemosky%2C+Stephen+J%3BLiu%2C+Chengyu%3BStonik%2C+John+A%3BSampson%2C+Maureen+L%3BPryor%2C+Milton%3BBocharov%2C+Alexander+V%3BEggerman%2C+Thomas+L%3BPatterson%2C+Amy+P%3BRemaley%2C+Alan+T&rft.aulast=Vaisman&rft.aufirst=Boris&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F607120
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-01-01
N1 - Number of references - 1
N1 - Last updated - 2016-05-13
N1 - SubjectsTermNotLitGenreText - Diets; Atherogenic diet; Aorta; Lipoproteins (high density); Transgenes; Animal models; Cell culture; Cholesterol; Arteriosclerosis; Transgenic mice; Endothelial cells; Lipoproteins; Endothelium; Liver; scavenger receptors
DO - http://dx.doi.org/10.1155/2015/607120
ER -
TY - JOUR
T1 - Acceptable Approaches to Enrolling Adults Who Cannot Consent in More Than Minimal Risk Research
AN - 1753465623; PQ0002370724
JF - American Journal of Bioethics
AU - Danis, Marion
AU - Wendler, David
AU - Kim, Scott
AD - National Institutes of Health Clinical Center
PY - 2015
SP - 70
EP - 71
PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom
VL - 15
IS - 10
SN - 1526-5161, 1526-5161
KW - Environment Abstracts
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753465623?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Bioethics&rft.atitle=Acceptable+Approaches+to+Enrolling+Adults+Who+Cannot+Consent+in+More+Than+Minimal+Risk+Research&rft.au=Danis%2C+Marion%3BWendler%2C+David%3BKim%2C+Scott&rft.aulast=Danis&rft.aufirst=Marion&rft.date=2015-01-01&rft.volume=15&rft.issue=10&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Bioethics&rft.issn=15265161&rft_id=info:doi/10.1080%2F15265161.2015.1075806
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-01-01
N1 - Last updated - 2016-01-06
DO - http://dx.doi.org/10.1080/15265161.2015.1075806
ER -
TY - JOUR
T1 - Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer: clinical results and biological observations in taxane-pretreated patients
AN - 1753464302; PQ0002418717
AB - There is a deep need to improve the care of metastatic breast cancer (MBC) patients, since even today it remains an incurable disease. Taxanes are considered the most effective cytotoxic drugs for the treatment of MBC, both in monotherapy and in combined schedules, but the need for synthetic solvents contributes to the severe toxicities and may have a negative impact on the efficacy. Nanoparticle albumin-bound paclitaxel (Nab-paclitaxel) is a colloidal suspension of paclitaxel and human serum albumin initially developed to avoid the toxicities associated with conventional taxanes. The aim of this prospective, single-center open-label, noncomparative study was to evaluate the efficacy and safety of nab-paclitaxel in MBC patients pretreated with taxanes. The patients were treated with nab-paclitaxel as a single agent, 260 mg/m2 on day 1 of each 3-week cycle or 125 mg/m2 weekly. The primary endpoint was the overall response rate (ORR). Secondary objectives were duration of response, clinical benefit rate, progression-free survival (PFS), overall survival, and safety. A total of 42 patients (median age 48 years, median Eastern Cooperative Oncology Group performance status 0, triple-negative MBC 19%, all pretreated with a taxane-based therapy, mainly in advanced disease) were enrolled in the study. The ORR was 23.8%, including one complete response (2.4%) and nine partial responses (21.4%); the disease control rate was 50%. The median duration of response was 7.2 months. After a median follow-up of 9 months, the median PFS was 4.6 months. ORR and PFS were similar irrespective of the previous chemotherapy lines, metastatic sites, and biomolecular expression. Nab-paclitaxel was well tolerated, and the most frequent treatment-related toxicities were mild to moderate (grades 1-2). This real-life study shows that nab-paclitaxel has a significant antitumor activity and a manageable safety profile in patients pretreated with taxanes and experiencing a treatment failure after at least one line of chemotherapy.
JF - Drug Design, Development and Therapy
AU - Fabi, Alessandra
AU - Giannarelli, Diana
AU - Malaguti, Paola
AU - Ferretti, Gianluigi
AU - Vari, Sabrina
AU - Papaldo, Paola
AU - Nistico, Cecilia
AU - Caterino, Mauro
AU - De Vita, Roy
AU - Mottolese, Marcella
AU - Iacorossi, Laura
AU - Cognetti, Francesco
AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy
PY - 2015
SP - 6177
EP - 6183
PB - Dove Medical Press Ltd, Beechfield House Macclesfield SK11 0JL United Kingdom
VL - 9
KW - Biotechnology and Bioengineering Abstracts
KW - nab-paclitaxel
KW - metastatic breast cancer
KW - anthracyclines
KW - Age
KW - Chemotherapy
KW - Disease control
KW - Solvents
KW - Survival
KW - taxanes
KW - human serum albumin
KW - Drug development
KW - Oncology
KW - Toxicity
KW - Metastases
KW - Cytotoxicity
KW - Paclitaxel
KW - Breast cancer
KW - nanoparticles
KW - Antitumor activity
KW - W 30915:Pharmaceuticals & Vaccines
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753464302?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Design%2C+Development+and+Therapy&rft.atitle=Prospective+study+on+nanoparticle+albumin-bound+paclitaxel+in+advanced+breast+cancer%3A+clinical+results+and+biological+observations+in+taxane-pretreated+patients&rft.au=Fabi%2C+Alessandra%3BGiannarelli%2C+Diana%3BMalaguti%2C+Paola%3BFerretti%2C+Gianluigi%3BVari%2C+Sabrina%3BPapaldo%2C+Paola%3BNistico%2C+Cecilia%3BCaterino%2C+Mauro%3BDe+Vita%2C+Roy%3BMottolese%2C+Marcella%3BIacorossi%2C+Laura%3BCognetti%2C+Francesco&rft.aulast=Fabi&rft.aufirst=Alessandra&rft.date=2015-01-01&rft.volume=9&rft.issue=&rft.spage=6177&rft.isbn=&rft.btitle=&rft.title=Drug+Design%2C+Development+and+Therapy&rft.issn=1177-8881&rft_id=info:doi/10.2147%2FDDDT.S89575
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-01-01
N1 - Last updated - 2016-01-21
N1 - SubjectsTermNotLitGenreText - Age; Chemotherapy; Solvents; Disease control; human serum albumin; taxanes; Survival; Oncology; Drug development; Toxicity; Metastases; Cytotoxicity; Paclitaxel; Breast cancer; nanoparticles; Antitumor activity
DO - http://dx.doi.org/10.2147/DDDT.S89575
ER -
TY - JOUR
T1 - Quantitative assessment of myocardial fibrosis in an age-related rat model by ex vivo late gadolinium enhancement magnetic resonance imaging with histopathological correlation
AN - 1751214996; PQ0002336595
AB - Late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) imaging can detect the presence of myocardial infarction from ischemic cardiomyopathies (ICM). However, it is more challenging to detect diffuse myocardial fibrosis from non-ischemic cardiomyopathy (NICM) with this technique due to more subtle and heterogeneous enhancement of the myocardium. This study investigates whether high-resolution LGE CMR can detect age-related myocardial fibrosis using quantitative texture analysis with histological validation. LGE CMR of twenty-four rat hearts (twelve 6-week-old and twelve 2-year-old) was performed using a 7T MRI scanner. Picrosirius red was used as the histopathology reference for collagen staining. Fibrosis in the myocardium was quantified with standard deviation (SD) threshold methods from the LGE CMR images and 3D contrast texture maps that were computed from gray level co-occurrence matrix of the CMR images. There was a significant increase of collagen fibers in the aged compared to the young rat histology slices (2.60 plus or minus 0.27 %LV vs. 1.24 plus or minus 0.29 %LV, p<0.01). Both LGE CMR and texture images showed a significant increase of myocardial fibrosis in the elderly compared to the young rats. Fibrosis in the LGE CMR images correlated strongly with histology with the 3 SD threshold (r=0.84, y=0.99x+0.00). Similarly, fibrosis in the contrast texture maps correlated with the histology using the 4 SD threshold (r=0.89, y=1.01x+0.00). High resolution ex-vivo LGE CMR can detect the presence of diffuse fibrosis that naturally developed in elderly rat hearts. Our results suggest that texture analysis may improve the assessment of myocardial fibrosis in LGE CMR images.
JF - Computers in Biology and Medicine
AU - Beliveau, Pascale
AU - Cheriet, Farida
AU - Anderson, Stasia A
AU - Taylor, Joni L
AU - Arai, Andrew E
AU - Hsu, Li-Yueh
AD - National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
PY - 2015
SP - 103
EP - 113
PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom
VL - 65
SN - 0010-4825, 0010-4825
KW - Biotechnology and Bioengineering Abstracts
KW - CMR cardiac magnetic resonance
KW - DTI diffusion tensor imaging
KW - DTPA diethylenetriamine pentaacetic acid
KW - ECV extracellular volume fraction
KW - Gd gadolinium
KW - GLCM gray level co-occurrence matrix
KW - HSV hue-saturation-value
KW - ICM ischemic cardiomyopathies
KW - LGE late gadolinium enhancement
KW - LV left ventricular
KW - NICM non-ischemic cardiomyopathy
KW - NS not statically significant
KW - ROI region of interest
KW - SA short-axis
KW - SI signal intensity
KW - SD standard deviation
KW - Diffuse myocardial fibrosis
KW - Gadolinium
KW - Magnetic resonance imaging
KW - Texture analysis
KW - Computer quantification
KW - Aging
KW - Heart
KW - Age
KW - Fibrosis
KW - Ischemia
KW - Maps
KW - Computer applications
KW - Myocardial infarction
KW - Collagen
KW - Cardiomyopathy
KW - Fibers
KW - Standard deviation
KW - Geriatrics
KW - Myocardium
KW - W 30960:Bioinformatics & Computer Applications
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751214996?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+in+Biology+and+Medicine&rft.atitle=Quantitative+assessment+of+myocardial+fibrosis+in+an+age-related+rat+model+by+ex+vivo+late+gadolinium+enhancement+magnetic+resonance+imaging+with+histopathological+correlation&rft.au=Beliveau%2C+Pascale%3BCheriet%2C+Farida%3BAnderson%2C+Stasia+A%3BTaylor%2C+Joni+L%3BArai%2C+Andrew+E%3BHsu%2C+Li-Yueh&rft.aulast=Beliveau&rft.aufirst=Pascale&rft.date=2015-01-01&rft.volume=65&rft.issue=&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Computers+in+Biology+and+Medicine&rft.issn=00104825&rft_id=info:doi/10.1016%2Fj.compbiomed.2015.07.027
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-12-01
N1 - Number of references - 48
N1 - Last updated - 2016-01-21
N1 - SubjectsTermNotLitGenreText - Heart; Age; Fibrosis; Magnetic resonance imaging; Gadolinium; Ischemia; Computer applications; Maps; Myocardial infarction; Collagen; Fibers; Cardiomyopathy; Standard deviation; Geriatrics; Myocardium
DO - http://dx.doi.org/10.1016/j.compbiomed.2015.07.027
ER -
TY - JOUR
T1 - Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease
AN - 1746874544; PQ0002167264
AB - The crystal structures of two constructs of RC1339/APRc from Rickettsia conorii, consisting of either residues 105-231 or 110-231 followed by a His tag, have been determined in three different crystal forms. As predicted, the fold of a monomer of APRc resembles one-half of the mandatory homodimer of retroviral pepsin-like aspartic proteases (retropepsins), but the quaternary structure of the dimer of APRc differs from that of the canonical retropepsins. The observed dimer is most likely an artifact of the expression and/or crystallization conditions since it cannot support the previously reported enzymatic activity of this bacterial aspartic protease. However, the fold of the core of each monomer is very closely related to the fold of retropepsins from a variety of retroviruses and to a single domain of pepsin-like eukaryotic enzymes, and may represent a putative common ancestor of monomeric and dimeric aspartic proteases.
JF - Acta Crystallographica Section D
AU - Li, Mi
AU - Gustchina, Alla
AU - Cruz, Rui
AU - Simoes, Marisa
AU - Curto, Pedro
AU - Martinez, Juan
AU - Faro, Carlos
AU - Simoes, Isaura
AU - Wlodawer, Alexander
AD - Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
PY - 2015
SP - 2109
EP - 2118
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 71
IS - 10
SN - 1399-0047, 1399-0047
KW - Microbiology Abstracts B: Bacteriology
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746874544?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+D&rft.atitle=Structure+of+RC1339%2FAPRc+from+Rickettsia+conorii%2C+a+retropepsin-like+aspartic+protease&rft.au=Li%2C+Mi%3BGustchina%2C+Alla%3BCruz%2C+Rui%3BSimoes%2C+Marisa%3BCurto%2C+Pedro%3BMartinez%2C+Juan%3BFaro%2C+Carlos%3BSimoes%2C+Isaura%3BWlodawer%2C+Alexander&rft.aulast=Li&rft.aufirst=Mi&rft.date=2015-01-01&rft.volume=71&rft.issue=10&rft.spage=2109&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+D&rft.issn=13990047&rft_id=info:doi/10.1107%2FS1399004715013905
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-12-01
N1 - Last updated - 2015-12-09
DO - http://dx.doi.org/10.1107/S1399004715013905
ER -
TY - JOUR
T1 - Does focal incidental super(18)F-FDG PET/CT uptake in the prostate have significance?
AN - 1735922376; PQ0002271374
AB - super(18)F-FDG PET/CT is used to characterize many malignancies, but is not recommended for localized prostate cancer. This study explores the value of multi-parametric MRI (mpMRI) in characterizing incidental prostate super(18)F-FDG uptake. Thirty-one patients who underwent super(18)F-FDG PET/CT for reasons unrelated to prostate cancer and prostate mpMRI were eligible for this retrospective study. The mpMRI included T2-weighted (T2W), dynamic contrast enhancement (DCE), apparent diffusion coefficient (ADC), and MR spectroscopy (MRS) sequences. Fourteen patients were excluded (n = 8 insufficient histopathology, n = 6 radical prostatectomy before PET), and final analysis included 17 patients. A nuclear medicine physician, blinded to clinicopathologic findings, identified suspicious areas and maximum standardized uptake values (SUVmax) on super(18)F-FDG PET/CT. Sector-based imaging findings were correlated with annotated histopathology from whole-mount or MRI/transrectal ultrasound fusion biopsy samples. Positive predictive values (PPVs) were estimated using generalized estimating equations with logit link. Results were evaluated with Kruskal-Wallis and Dunn's multiple comparisons tests. The PPV of super(18)F-FDG PET alone in detecting prostate cancer was 0.65. Combining super(18)F-FDG PET as a base parameter with mpMRI (T2W, DCE, ADC, and MRS) increased the PPV to 0.82, 0.83, 0.83, and 0.94, respectively. All benign lesions had SUVmax 6. Using mpMRI to further evaluate incidental super(18)F-FDG uptake aids the diagnosis of prostate cancer.
JF - Abdominal Imaging
AU - Brown, Anna M
AU - Lindenberg, Maria L
AU - Sankineni, Sandeep
AU - Shih, Joanna H
AU - Johnson, Linda M
AU - Pruthy, Suneha
AU - Kurdziel, Karen A
AU - Merino, Maria J
AU - Wood, Bradford J
AU - Pinto, Peter A
AU - Choyke, Peter L
AU - Turkbey, Baris
AD - Molecular Imaging Program, National Cancer Institute, NIH, 10 Center Drive, Room B3B85, Bethesda, MD, 20892, USA, turkbeyi@mail.nih.gov
PY - 2015
SP - 3222
EP - 3229
PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands
VL - 40
IS - 8
SN - 0942-8925, 0942-8925
KW - Biotechnology and Bioengineering Abstracts
KW - Mathematical models
KW - Magnetic resonance imaging
KW - Biopsy
KW - Malignancy
KW - Prostate cancer
KW - Magnetic resonance spectroscopy
KW - Computed tomography
KW - Positron emission tomography
KW - Nuclear medicine
KW - Diffusion coefficient
KW - Ultrasound
KW - Benign
KW - W 30910:Imaging
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735922376?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abdominal+Imaging&rft.atitle=Does+focal+incidental+super%2818%29F-FDG+PET%2FCT+uptake+in+the+prostate+have+significance%3F&rft.au=Brown%2C+Anna+M%3BLindenberg%2C+Maria+L%3BSankineni%2C+Sandeep%3BShih%2C+Joanna+H%3BJohnson%2C+Linda+M%3BPruthy%2C+Suneha%3BKurdziel%2C+Karen+A%3BMerino%2C+Maria+J%3BWood%2C+Bradford+J%3BPinto%2C+Peter+A%3BChoyke%2C+Peter+L%3BTurkbey%2C+Baris&rft.aulast=Brown&rft.aufirst=Anna&rft.date=2015-01-01&rft.volume=40&rft.issue=8&rft.spage=3222&rft.isbn=&rft.btitle=&rft.title=Abdominal+Imaging&rft.issn=09428925&rft_id=info:doi/10.1007%2Fs00261-015-0520-y
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-11-01
N1 - Number of references - 14
N1 - Last updated - 2015-12-09
N1 - SubjectsTermNotLitGenreText - Malignancy; Mathematical models; Prostate cancer; Magnetic resonance spectroscopy; Magnetic resonance imaging; Computed tomography; Positron emission tomography; Nuclear medicine; Biopsy; Diffusion coefficient; Ultrasound; Benign
DO - http://dx.doi.org/10.1007/s00261-015-0520-y
ER -
TY - JOUR
T1 - Performance of the BG1Luc ER TA method in a qHTS format.
AN - 1733191246; 26117232
AB - In 2012, the BG1Luc4E2 estrogen receptor (ER) transactivation (TA) method (BG1Luc ER TA) was accepted by U.S. regulatory agencies and the Organisation for Economic Co-operation and Development to detect substances with ER agonist activity. The method is now part of the Tier 1 testing battery in the Environmental Protection Agency's Endocrine Disruptor Screening Program. The BG1Luc ER TA method uses the BG1 ovarian cell line that endogenously expresses full-length ER (α and β) and is stably transfected with a plasmid containing four estrogen responsive elements upstream of a luciferase reporter gene. To allow increased throughput and testing efficiency, the BG1Luc ER TA ("BG1 manual") method was adapted for quantitative high-throughput screening (BG1 qHTS) in the U.S. Tox21 testing program. The BG1 qHTS test method was used to test approximately 10,000 chemicals three times each, and concentration-response data (n=15) were analyzed to evaluate test method performance. The balanced accuracy of the BG1 qHTS test method (97% [32/33]) was determined by comparing results to ER TA performance standards for the BG1 manual method. Concordance between the BG1 manual and qHTS methods was 92% (57/62) when calculated for a larger set of non-reference chemicals tested in both methods. These data demonstrate that the performance of the BG1 qHTS is similar to the currently accepted BG1 manual method, thereby establishing the utility of the BG1 qHTS method for identifying ER active environmental chemicals.
JF - ALTEX
AU - Ceger, Patricia
AU - Allen, David
AU - Huang, Ruili
AU - Xia, Menghang
AU - Casey, Warren
AD - Integrated Laboratory Systems, Inc., Research Triangle Park, North Carolina, USA. ; National Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA. ; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Y1 - 2015
PY - 2015
DA - 2015
SP - 287
EP - 296
VL - 32
IS - 4
SN - 1868-596X, 1868-596X
KW - Endocrine Disruptors
KW - 0
KW - Estrogen Receptor alpha
KW - Index Medicus
KW - EDSP
KW - quantitative high-throughput screening
KW - BG1Luc ER TA
KW - Tox21
KW - United States
KW - Animal Testing Alternatives
KW - United States Environmental Protection Agency
KW - Protein Binding -- drug effects
KW - Humans
KW - Signal Transduction -- drug effects
KW - Cell Line
KW - High-Throughput Screening Assays -- methods
KW - Estrogen Receptor alpha -- agonists
KW - Endocrine Disruptors -- chemistry
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1733191246?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ALTEX&rft.atitle=Performance+of+the+BG1Luc+ER+TA+method+in+a+qHTS+format.&rft.au=Ceger%2C+Patricia%3BAllen%2C+David%3BHuang%2C+Ruili%3BXia%2C+Menghang%3BCasey%2C+Warren&rft.aulast=Ceger&rft.aufirst=Patricia&rft.date=2015-01-01&rft.volume=32&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=ALTEX&rft.issn=1868596X&rft_id=info:doi/http%3A%2F%2Fdx.doi.org%2F10.14573%2Faltex.1505121
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2016-06-20
N1 - Date created - 2015-11-11
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Erratum In:
ALTEX. 2016;33(1):79 [26776439]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.14573/altex.1505121
ER -
TY - JOUR
T1 - Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules
AN - 1732826766; PQ0002242120
AB - Linker for activation of T cells (LAT) is critical for the propagation of T-cell signals upon T-cell receptor (TCR) activation. Previous studies demonstrated that substitution of LAT lysines with arginines (2KR LAT) resulted in decreased LAT ubiquitination and elevated T-cell signaling, indicating that LAT ubiquitination is a molecular checkpoint for attenuation of T-cell signaling. To investigate the role of LAT ubiquitination in vivo, we have generated transgenic mice expressing WT and ubiquitin-defective 2KR LAT. On TCR stimulation of T cells from these mice, proximal signaling and cytokine production was elevated in 2KR versus wild-type (WT) LAT mice. Enhanced cytolytic activity as well as T-helper responses were observed on LAT expression, which were further elevated by 2KR LAT expression. Despite greater T-effector function, WT or 2KR LAT expression did not have any effect on clearance of certain pathogens or tumors. Our data support the model that lack of tumor clearance is due to increased differentiation and acquisition of effector phenotype that is associated with suboptimal immunity in an immunotherapy model. Thus, our data further reinforce the role of LAT ubiquitination in TCR signaling and uncovers a novel role for LAT in driving T-cell differentiation.
JF - Gene Therapy
AU - Rodriguez-Pena, A B
AU - Gomez-Rodriguez, J
AU - Kortum, R L
AU - Palmer, D C
AU - Yu, Z
AU - Guittard, G C
AU - Wohlfert, E A
AU - Silver, P B
AU - Misplon, J A
AU - Sommers, C L
AU - Feigenbaum, L
AU - Epstein, S L
AU - Caspi, R R
AU - Belkaid, Y
AU - Restifo, N P
AU - Samelson, L E
AU - Balagopalan, L
AD - Cell Signaling and Immunity Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
PY - 2015
SP - 781
EP - 792
PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom
VL - 22
IS - 10
SN - 0969-7128, 0969-7128
KW - Immunology Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW - T-cell receptor
KW - Data processing
KW - Gene therapy
KW - Arginine
KW - Immunotherapy
KW - Animal models
KW - Lysine
KW - Pathogens
KW - Tumors
KW - Transgenic mice
KW - Cell activation
KW - Differentiation
KW - ubiquitination
KW - Cytolytic activity
KW - Lymphocytes T
KW - Cytokines
KW - G 07720:Immunogenetics
KW - W 30905:Medical Applications
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732826766?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Enhanced+T-cell+activation+and+differentiation+in+lymphocytes+from+transgenic+mice+expressing+ubiquitination-resistant+2KR+LAT+molecules&rft.au=Rodriguez-Pena%2C+A+B%3BGomez-Rodriguez%2C+J%3BKortum%2C+R+L%3BPalmer%2C+D+C%3BYu%2C+Z%3BGuittard%2C+G+C%3BWohlfert%2C+E+A%3BSilver%2C+P+B%3BMisplon%2C+J+A%3BSommers%2C+C+L%3BFeigenbaum%2C+L%3BEpstein%2C+S+L%3BCaspi%2C+R+R%3BBelkaid%2C+Y%3BRestifo%2C+N+P%3BSamelson%2C+L+E%3BBalagopalan%2C+L&rft.aulast=Rodriguez-Pena&rft.aufirst=A&rft.date=2015-01-01&rft.volume=22&rft.issue=10&rft.spage=781&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2015.48
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-11-01
N1 - Last updated - 2015-12-09
N1 - SubjectsTermNotLitGenreText - T-cell receptor; Data processing; Gene therapy; Arginine; Immunotherapy; Animal models; Lysine; Tumors; Pathogens; Transgenic mice; Cell activation; ubiquitination; Differentiation; Cytolytic activity; Lymphocytes T; Cytokines
DO - http://dx.doi.org/10.1038/gt.2015.48
ER -
TY - JOUR
T1 - Entrectinib: a potent new TRK, ROS1, and ALK inhibitor.
AN - 1728673900; 26457764
AB - Receptor tyrosine kinases (RTKs) and their signaling pathways, control normal cellular processes; however, their deregulation play important roles in malignant transformation. In advanced non-small cell lung cancer (NSCLC), the recognition of oncogenic activation of specific RTKs, has led to the development of molecularly targeted agents that only benefit roughly 20% of patients. Entrectinib is a pan-TRK, ROS1 and ALK inhibitor that has shown potent anti-neoplastic activity and tolerability in various neoplastic conditions, particularly NSCLC.
This review outlines the pharmacokinetics, pharmacodynamics, mechanism of action, safety, tolerability, pre-clinical studies and clinical trials of entrectinib, a promising novel agent for the treatment of advanced solid tumors with molecular alterations of Trk-A, B and C, ROS1 or ALK. Among the several experimental drugs under clinical development, entrectinib is emerging as an innovative and promising targeted agent. The encouraging antitumor activity reported in the Phase 1 studies, together with the acceptable toxicity profile, suggest that entrectinib, thanks to its peculiar mechanism of action, could play an important role in the treatment-strategies of multiple TRK-A, B, C, ROS1, and ALK- dependent solid tumors, including NSCLC and colorectal cancer. That being said, further evidence for its clinical use is still needed.
JF - Expert opinion on investigational drugs
AU - Rolfo, Christian
AU - Ruiz, Rossana
AU - Giovannetti, Elisa
AU - Gil-Bazo, Ignacio
AU - Russo, Antonio
AU - Passiglia, Francesco
AU - Giallombardo, Marco
AU - Peeters, Marc
AU - Raez, Luis
AD - a Phase I - Early Clinical Trials Unit, Oncology Department , Antwerp University Hospital and Center for Oncological Research (CORE), Antwerp University , Edegem , Belgium. ; b Oncology Department , National Cancer Institute (INEN) , Lima , Peru. ; c Department Medical Oncology , VU University Medical Center , Amsterdam , The Netherlands. ; d Department of Oncology , Clínica Universidad de Navarra , Pamplona , Spain. ; e Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology , University of Palermo , Palermo , Italy. ; f Thoracic Oncology Program , Memorial Cancer Institute, Memorial Health Care System , Pembroke Pines , FL , USA.
Y1 - 2015
PY - 2015
DA - 2015
SP - 1493
EP - 1500
VL - 24
IS - 11
KW - Antineoplastic Agents
KW - 0
KW - Benzamides
KW - Indazoles
KW - Proto-Oncogene Proteins
KW - entrectinib
KW - Protein-Tyrosine Kinases
KW - EC 2.7.10.1
KW - ROS1 protein, human
KW - Receptor Protein-Tyrosine Kinases
KW - Receptor, trkA
KW - Receptor, trkB
KW - Receptor, trkC
KW - anaplastic lymphoma kinase
KW - Index Medicus
KW - non-small cell lung cancer
KW - salivary gland cancer
KW - colorectal cancer
KW - ALK
KW - NTRK3
KW - precision medicine
KW - NTRK1
KW - NTRK2
KW - TrkC
KW - ROS1
KW - TrkA
KW - Entrectinib
KW - TrkB
KW - Protein-Tyrosine Kinases -- antagonists & inhibitors
KW - Receptor, trkC -- antagonists & inhibitors
KW - Receptor, trkB -- antagonists & inhibitors
KW - Animals
KW - Proto-Oncogene Proteins -- antagonists & inhibitors
KW - Humans
KW - Receptor Protein-Tyrosine Kinases -- antagonists & inhibitors
KW - Receptor, trkA -- antagonists & inhibitors
KW - Neoplasms -- drug therapy
KW - Benzamides -- adverse effects
KW - Indazoles -- adverse effects
KW - Neoplasms -- pathology
KW - Benzamides -- pharmacology
KW - Indazoles -- pharmacology
KW - Indazoles -- therapeutic use
KW - Antineoplastic Agents -- therapeutic use
KW - Antineoplastic Agents -- pharmacology
KW - Benzamides -- therapeutic use
KW - Antineoplastic Agents -- adverse effects
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2016-05-23
N1 - Date created - 2015-10-31
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1517/13543784.2015.1096344
ER -
TY - JOUR
T1 - GNormPlus: An Integrative Approach for Tagging Genes, Gene Families, and Protein Domains
AN - 1722175691; PQ0002026600
AB - The automatic recognition of gene names and their associated database identifiers from biomedical text has been widely studied in recent years, as these tasks play an important role in many downstream text-mining applications. Despite significant previous research, only a small number of tools are publicly available and these tools are typically restricted to detecting only mention level gene names or only document level gene identifiers. In this work, we report GNormPlus: an end-to-end and open source system that handles both gene mention and identifier detection. We created a new corpus of 694 PubMed articles to support our development of GNormPlus, containing manual annotations for not only gene names and their identifiers, but also closely related concepts useful for gene name disambiguation, such as gene families and protein domains. GNormPlus integrates several advanced text-mining techniques, including SimConcept for resolving composite gene names. As a result, GNormPlus compares favorably to other state-of-the-art methods when evaluated on two widely used public benchmarking datasets, achieving 86.7% F1-score on the BioCreative II Gene Normalization task dataset and 50.1% F1-score on the BioCreative III Gene Normalization task dataset. The GNormPlus source code and its annotated corpus are freely available, and the results of applying GNormPlus to the entire PubMed are freely accessible through our web-based tool PubTator.
JF - BioMed Research International
AU - Wei, Chih-Hsuan
AU - Kao, Hung-Yu
AU - Lu, Zhiyong
AD - National Center for Biotechnology Information (NCBI), 8600 Rockville Pike, Bethesda, MD 20894, USA, zhiyong.lu@nih.gov
Y1 - 2015/01//
PY - 2015
DA - January 2015
PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States
VL - 2015
SN - 2314-6133, 2314-6133
KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW - Databases
KW - G 07730:Development & Cell Cycle
KW - W 30960:Bioinformatics & Computer Applications
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722175691?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=GNormPlus%3A+An+Integrative+Approach+for+Tagging+Genes%2C+Gene+Families%2C+and+Protein+Domains&rft.au=Wei%2C+Chih-Hsuan%3BKao%2C+Hung-Yu%3BLu%2C+Zhiyong&rft.aulast=Wei&rft.aufirst=Chih-Hsuan&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F918710
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-10-01
N1 - Number of references - 10
N1 - Last updated - 2016-05-13
N1 - SubjectsTermNotLitGenreText - Databases
DO - http://dx.doi.org/10.1155/2015/918710
ER -
TY - JOUR
T1 - Hierarchical decision making: resource distribution exhibits stronger effect on crayfish dominance relationships and shelter occupation than prior social experience and resource ownership
AN - 1722169703; PQ0002040446
AB - The outcome of agonistic interactions is critical to the acquisition of vital resources. These behaviours can be influenced by several intrinsic and extrinsic factors, and multi-faceted studies are necessary for ecologically relevant studies. The aim of this study was to combine the effects of past social experience, resource ownership, and the distribution of shelter resources to examine the combination of these effects on various measures of agonism in crayfish (Orconectes rusticus). Crayfish were assigned to one of three social conditioning treatments (naive, subordinate, dominant) and then introduced to an arena where they were assigned to a resident or intruder treatment. An intruder shelter was then positioned 20, 60 or 120 cm from the resident shelter. We found that resource distribution (shelter distance) played a larger role in influencing agonistic behaviour than did past social experience or current social status.
JF - Behaviour
AU - Chibucos, K
AU - Wofford, S J
AU - Moore, P A
AD - Program for Genomics Differentiation, Eunice K. Shiver Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA, pmoore@bgsu.edu
Y1 - 2015///0,
PY - 2015
DA - 0, 2015
SP - 1063
EP - 1082
PB - Brill Academic Publishers, P.O. Box 9000 Leiden PA 2300 Netherlands
VL - 152
SN - 0005-7959, 0005-7959
KW - Ecology Abstracts; ASFA 1: Biological Sciences & Living Resources; Animal Behavior Abstracts
KW - crayfish
KW - dominance
KW - prior residence
KW - resource ownership
KW - shelter
KW - social status
KW - status reversal
KW - Predation
KW - Cambaridae
KW - Shelter
KW - Freshwater
KW - Agonistic behaviour
KW - Orconectes rusticus
KW - Dominance hierarchies
KW - Social interactions
KW - Dominance
KW - Decision making
KW - Intruder
KW - Freshwater crustaceans
KW - Shelters
KW - Property rights
KW - Territoriality
KW - D 04040:Ecosystem and Ecology Studies
KW - Q1 08604:Stock assessment and management
KW - Y 25070:Learning, Memory, Reinforcement, and Motivation
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722169703?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour&rft.atitle=Hierarchical+decision+making%3A+resource+distribution+exhibits+stronger+effect+on+crayfish+dominance+relationships+and+shelter+occupation+than+prior+social+experience+and+resource+ownership&rft.au=Chibucos%2C+K%3BWofford%2C+S+J%3BMoore%2C+P+A&rft.aulast=Chibucos&rft.aufirst=K&rft.date=2015-01-01&rft.volume=152&rft.issue=&rft.spage=1063&rft.isbn=&rft.btitle=&rft.title=Behaviour&rft.issn=00057959&rft_id=info:doi/10.1163%2F1568539X-00003292
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-10-01
N1 - Last updated - 2016-12-22
N1 - SubjectsTermNotLitGenreText - Predation; Freshwater crustaceans; Property rights; Shelters; Territoriality; Agonistic behaviour; Dominance hierarchies; Decision making; Intruder; Shelter; Dominance; Social interactions; Cambaridae; Orconectes rusticus; Freshwater
DO - http://dx.doi.org/10.1163/1568539X-00003292
ER -
TY - JOUR
T1 - Genetic and Phenotypic Properties of Vero Cell-Adapted Japanese Encephalitis Virus SA14-14-2 Vaccine Strain Variants and a Recombinant Clone, Which Demonstrates Attenuation and Immunogenicity in Mice
AN - 1722168082; PQ0002059450
AB - The live-attenuated Japanese encephalitis virus CEV) SA14-14-2 vaccine, produced in primary hamster kidney cells, is safe and effective. Past attempts to adapt this virus to replicate in cells that are more favorable for vaccine production resulted in mutations that significantly reduced immunogenicity. In this study, 10 genetically distinct Vero cell-adapted JEV SA14-14-2 variants were isolated and a recombinant wild-type JEV clone, modified to contain the JEV SA14-14-2 polyprotein amino acid sequence, was recovered in Vero cells. A single capsid protein mutation (S66L) was important for Vero cell-adaptation. Mutations were also identified that modulated virus sensitivity to type I interferon-stimulation in Vero cells. A subset of JEV SA14-14-2 variants and the recombinant clone were evaluated in vivo and exhibited levels of attenuation that varied significantly in suckling mice, but were avirulent and highly immunogenic in weanling mice and are promising candidates for the development of a second-generation, recombinant vaccine.
JF - American Journal of Tropical Medicine and Hygiene
AU - Gromowski, Gregory D
AU - Firestone, Cai-Yen
AU - Bustos-Arriaga, Jose
AU - Whitehead, Stephen S
AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, gromowskig@niaid.nih.gov
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 98
EP - 107
PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States
VL - 92
IS - 1
SN - 0002-9637, 0002-9637
KW - Genetics Abstracts; CSA Neurosciences Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality
KW - Clones
KW - polyproteins
KW - Vero cells
KW - Mutations
KW - Disease control
KW - Suckling behavior
KW - Attenuation
KW - Kidneys
KW - Phenotypes
KW - Encephalitis
KW - Recombinants
KW - Immunogenicity
KW - Kidney
KW - Japanese encephalitis virus
KW - Vaccines
KW - Hygiene
KW - Mutation
KW - Capsid protein
KW - Amino acid sequence
KW - K 03410:Animal Diseases
KW - Q5 08503:Characteristics, behavior and fate
KW - N3 11029:Neurophysiology & biophysics
KW - F 06905:Vaccines
KW - V 22350:Immunology
KW - J 02350:Immunology
KW - Q1 08485:Species interactions: pests and control
KW - G 07730:Development & Cell Cycle
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722168082?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Genetic+and+Phenotypic+Properties+of+Vero+Cell-Adapted+Japanese+Encephalitis+Virus+SA14-14-2+Vaccine+Strain+Variants+and+a+Recombinant+Clone%2C+Which+Demonstrates+Attenuation+and+Immunogenicity+in+Mice&rft.au=Gromowski%2C+Gregory+D%3BFirestone%2C+Cai-Yen%3BBustos-Arriaga%2C+Jose%3BWhitehead%2C+Stephen+S&rft.aulast=Gromowski&rft.aufirst=Gregory&rft.date=2015-01-01&rft.volume=92&rft.issue=1&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0427
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-10-01
N1 - Last updated - 2016-10-12
N1 - SubjectsTermNotLitGenreText - Clones; Recombinants; Mutations; Disease control; Attenuation; Kidneys; Vaccines; Hygiene; Phenotypes; polyproteins; Vero cells; Immunogenicity; Kidney; Suckling behavior; Mutation; Encephalitis; Amino acid sequence; Capsid protein; Japanese encephalitis virus
DO - http://dx.doi.org/10.4269/ajtmh.14-0427
ER -
TY - JOUR
T1 - Synthesis and characterisation of ultrasound imageable heat-sensitive liposomes for HIFU therapy.
AN - 1713529735; 26185910
AB - Novel approaches allowing efficient, readily translatable image-guided drug delivery (IGDD) against solid tumours is needed. The objectives of this study were to: 1) develop echogenic low temperature sensitive liposomes (E-LTSLs) loaded with an ultrasound (US) contrast agent (perfluoropentane, PFP), 2) determine the in vitro and in vivo stability of contrast agent encapsulation, 3) co-encapsulate and characterise doxorubicin (Dox) E-LTSL, and cellular uptake and cytotoxicity in combination with high intensity focused ultrasound (HIFU). E-LTSLs were loaded passively with PFP and actively with Dox. PFP encapsulation in E-LTSL was determined by transmission electron microscopy (TEM), and US imageability was determined in tissue-mimicking phantoms and mouse tumour model. Dox release from E-LTSL in physiological buffer was quantified by fluorescence spectroscopy. Cellular uptake and cytotoxicity of E-LTSL in the presence of HIFU-induced mild hyperthermia (∼40-42 °C) was determined in a 3D tumour spheroid model.
TEM and US confirmed that the PFP emulsion was contained within LTSLs. Phantom and animal studies showed that the E-LTSLs were echogenic. Temperature versus size increase and Dox release kinetics of E-LTSLs demonstrated no difference compared to LTSL alone. Dox release was 99% under hyperthermia. E-LTSL plus HIFU achieved significantly greater Dox uptake in spheroids and cytotoxicity compared to body temperature.
A stable US-imageable liposome co-loaded with Dox and PFP for in vivo IGDD was developed. Data suggest that HIFU can induce cellular uptake and toxicity with E-LTSLs.
JF - International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
AU - Maples, Danny
AU - McLean, Kevin
AU - Sahoo, Kaustuv
AU - Newhardt, Ryan
AU - Venkatesan, Perumal
AU - Wood, Bradford
AU - Ranjan, Ashish
AD - a Center for Veterinary Health Sciences, Oklahoma State University , Stillwater , Oklahoma and. ; b Center for Interventional Oncology, National Institutes of Health , Bethesda , Maryland , USA.
Y1 - 2015
PY - 2015
DA - 2015
SP - 674
EP - 685
VL - 31
IS - 6
KW - Antibiotics, Antineoplastic
KW - 0
KW - Contrast Media
KW - Fluorocarbons
KW - Liposomes
KW - perfluoropentane
KW - 678-26-2
KW - Doxorubicin
KW - 80168379AG
KW - Index Medicus
KW - Echogenic heat-sensitive liposome
KW - Tumor
KW - HIFU
KW - Spheroid
KW - Perfluoropentane
KW - Image Guided Drug Delivery
KW - Hot Temperature
KW - Animals
KW - Humans
KW - Mice, Nude
KW - Cell Line, Tumor
KW - Mice, Inbred BALB C
KW - Male
KW - Doxorubicin -- pharmacokinetics
KW - Fluorocarbons -- pharmacokinetics
KW - Neoplasms -- drug therapy
KW - Antibiotics, Antineoplastic -- administration & dosage
KW - Contrast Media -- pharmacokinetics
KW - High-Intensity Focused Ultrasound Ablation
KW - Doxorubicin -- administration & dosage
KW - Neoplasms -- therapy
KW - Antibiotics, Antineoplastic -- pharmacokinetics
KW - Antibiotics, Antineoplastic -- therapeutic use
KW - Fluorocarbons -- administration & dosage
KW - Contrast Media -- administration & dosage
KW - Doxorubicin -- therapeutic use
KW - Neoplasms -- metabolism
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1713529735?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+hyperthermia+%3A+the+official+journal+of+European+Society+for+Hyperthermic+Oncology%2C+North+American+Hyperthermia+Group&rft.atitle=Synthesis+and+characterisation+of+ultrasound+imageable+heat-sensitive+liposomes+for+HIFU+therapy.&rft.au=Maples%2C+Danny%3BMcLean%2C+Kevin%3BSahoo%2C+Kaustuv%3BNewhardt%2C+Ryan%3BVenkatesan%2C+Perumal%3BWood%2C+Bradford%3BRanjan%2C+Ashish&rft.aulast=Maples&rft.aufirst=Danny&rft.date=2015-01-01&rft.volume=31&rft.issue=6&rft.spage=674&rft.isbn=&rft.btitle=&rft.title=International+journal+of+hyperthermia+%3A+the+official+journal+of+European+Society+for+Hyperthermic+Oncology%2C+North+American+Hyperthermia+Group&rft.issn=1464-5157&rft_id=info:doi/10.3109%2F02656736.2015.1057622
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2016-07-01
N1 - Date created - 2015-09-16
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Langmuir. 2012 Oct 16;28(41):14720-9 [22989347]
Invest Radiol. 2013 Jun;48(6):395-405 [23399809]
Int J Hyperthermia. 2013 Sep;29(6):569-81 [23957326]
Theranostics. 2013;3(9):687-91 [24019853]
BioDrugs. 2013 Oct;27(5):533-40 [24018470]
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Contrast Media Mol Imaging. 2014 Jul-Aug;9(4):283-90 [24706612]
Cancer Res. 2000 Mar 1;60(5):1197-201 [10728674]
Cancer Res. 2000 Dec 15;60(24):6950-7 [11156395]
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Ann Oncol. 2004 Mar;15(3):440-9 [14998846]
Science. 2004 Mar 19;303(5665):1818-22 [15031496]
Magn Reson Med. 2004 Jun;51(6):1153-62 [15170835]
Eur J Cancer. 2004 Dec;40(18):2851-8 [15571970]
Inhal Toxicol. 2005 Aug;17(9):487-93 [16020043]
Biochem Biophys Res Commun. 2005 Sep 16;335(1):124-31 [16055092]
Magn Reson Med. 2006 Nov;56(5):1011-8 [17029236]
J Natl Cancer Inst. 2007 Jan 3;99(1):53-63 [17202113]
J Natl Cancer Inst. 2007 Jul 18;99(14):1095-106 [17623798]
Biochim Biophys Acta. 2007 Oct;1768(10):2491-9 [17618599]
Int J Hyperthermia. 2008 Feb;24(1):79-90 [18214771]
Adv Drug Deliv Rev. 2008 Jun 30;60(10):1153-66 [18486268]
Langmuir. 2010 Apr 6;26(7):4655-60 [20218695]
Int J Hyperthermia. 2011;27(2):140-55 [21314334]
J Control Release. 2011 Feb 28;150(1):102-10 [21059375]
Biomaterials. 2011 Sep;32(27):6579-87 [21683439]
J Control Release. 2011 Jul 15;153(1):4-15 [21277919]
J Control Release. 2011 Aug 10;153(3):198-205 [21663778]
J Control Release. 2011 Nov 7;155(3):358-66 [21745505]
J Control Release. 2012 Mar 28;158(3):487-94 [22210162]
Radiology. 2012 Jun;263(3):633-43 [22623690]
Radiology. 2012 Aug;264(2):349-68 [22821695]
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Sep-Oct;4(5):492-510 [22730185]
J Control Release. 2012 Sep 10;162(2):400-6 [22759980]
J Control Release. 2012 Oct 10;163(1):75-81 [22580225]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.3109/02656736.2015.1057622
ER -
TY - JOUR
T1 - Chondroitin sulfate proteoglycan 4 as a target for chimeric antigen receptor-based T-cell immunotherapy of solid tumors.
AN - 1713527622; 26190756
AB - Proteoglycans are critical molecules involved in multiple physiological cell functions, but also key players in cancer development and progression. In particular, chondroitin sulfate proteoglycan 4 (CSPG4) is recognized as an attractive target for antibody-based approaches because of its high expression on cancer cells in several types of human malignancies and its restricted distribution in normal tissues.
Adoptive transfer of genetically modified T cells is emerging as a powerful therapeutic approach in cancer patients. In this regard, the selection of the appropriate antigen to be targeted in solid tumors becomes a critical aspect in promoting potent antitumor effects while preventing toxicities. This review summarizes the authors' current knowledge on the expression and function of CSPG4 in normal tissues and malignant tumors, with a particular focus on the potential use of CSPG4 as a target for antigen-specificity redirected T cells. T cells expressing a CSPG4-specific chimeric antigen receptor (CAR) offer the possibility to target a broad spectrum of solid tumors for which no curative treatment is currently available. In addition, since CSPG4 is also selectively up-regulated on tumor-associated pericytes, targeting this antigen may also contribute to tumor regression via inhibition of neoangiogenesis. Preclinical experiments to date justify the clinical translation of CSPG4-specific CAR-T cells.
JF - Expert opinion on therapeutic targets
AU - Wang, Yangyang
AU - Geldres, Claudia
AU - Ferrone, Soldano
AU - Dotti, Gianpietro
AD - a 1 Massachusetts General Hospital, Harvard Medical School, Department of Surgery , 55 Fruit Street, Boston, MA 02114, USA Sferrone@MGH.Harvard.edu. ; b 2 National Cancer Institute, Experimental Transplantation and Immunology Branch , Bethesda, MD 20892, USA. ; c 3 University of North Carolina, Lineberger Comprehensive Cancer Center , Chapel Hill, NC, USA gdotti@med.unc.edu.
Y1 - 2015
PY - 2015
DA - 2015
SP - 1339
EP - 1350
VL - 19
IS - 10
KW - Antigens
KW - 0
KW - Proteoglycans
KW - Receptors, Antigen, T-Cell
KW - chondroitin sulfate proteoglycan 4
KW - Index Medicus
KW - T-cell therapies
KW - solid tumors
KW - chimeric antigen receptor
KW - CSPG4
KW - Animals
KW - Humans
KW - Molecular Targeted Therapy
KW - Receptors, Antigen, T-Cell -- immunology
KW - T-Lymphocytes -- immunology
KW - Neoplasms -- pathology
KW - Neoplasms -- therapy
KW - Antigens -- immunology
KW - Proteoglycans -- immunology
KW - Neoplasms -- immunology
KW - Immunotherapy -- methods
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1713527622?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+therapeutic+targets&rft.atitle=Chondroitin+sulfate+proteoglycan+4+as+a+target+for+chimeric+antigen+receptor-based+T-cell+immunotherapy+of+solid+tumors.&rft.au=Wang%2C+Yangyang%3BGeldres%2C+Claudia%3BFerrone%2C+Soldano%3BDotti%2C+Gianpietro&rft.aulast=Wang&rft.aufirst=Yangyang&rft.date=2015-01-01&rft.volume=19&rft.issue=10&rft.spage=1339&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+therapeutic+targets&rft.issn=1744-7631&rft_id=info:doi/10.1517%2F14728222.2015.1068759
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2016-05-05
N1 - Date created - 2015-09-16
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1517/14728222.2015.1068759
ER -
TY - JOUR
T1 - The Implementation Road: Engaging Community Partnerships in Evidence-Based Cancer Control Interventions
AN - 1708526700; 2011-842022
AB - Southern rural and underserved counties have high proportions of individuals with increased mortality for cervical and breast cancers. To improve the integration of behavioral research into practice, the dissemination and implementation of efficacious interventions to encourage the use of screening have increased in recent years. This study addressed gaps in the dissemination and implementation of evidence-based interventions with a pilot called Team Up. Qualitative interviews with 24 key individuals in six state-level partnerships explored partnership characteristics that influenced selection and use of evidence-based interventions among low-income, rarely or never screened women. Guided by diffusion of innovations theory and the Lasker and Weiss partnership functioning model, interviews about the intervention centered on (a) knowledge surrounding evidence base; (b) identification, selection, and adoption; (c) planning and adaptation; (d) implementation; and (e) partnership reflections and impact. Using grounded theory and content analysis, data revealed that lack of communication and high partner turnover hindered adoption and adaptation, whereas failure of partnership leaders to engage local stakeholders and lack of sufficient funds hampered implementation. Delivery of evidence-based interventions was more effective when partnerships included local partners in early decision making and when coaches were introduced to facilitate strategic thinking about translating evidence-based interventions into practice. A challenge for public health partnerships was the translation of interventions into successful programs, such that underserved communities benefited from early detection intervention research. [Reprinted by permission of Sage Publications Inc., copyright holder.]
JF - Health Promotion Practice
AU - Breslau, Erica S
AU - Weiss, Elisa S
AU - Williams, Abigail
AU - Burness, Allison
AU - Kepka, Deanna
AD - National Cancer Institute, Bethesda, MD, USA
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 46
EP - 54
PB - Sage Publications, Thousand Oaks CA
VL - 16
IS - 1
SN - 1524-8399, 1524-8399
KW - Business and service sector - Business organization and administration
KW - Health conditions and policy - Health and health policy
KW - Population groups, population policy, and demographics - Women
KW - Population groups, population policy, and demographics - Demography and census
KW - Health conditions and policy - Diseases and disorders
KW - Science and technology policy - Technology and technology policy
KW - Social conditions and policy - Communication
KW - cancer prevention and control health disparities health education health promotion partnerships/coalitions program planning and evaluation women's health
KW - Mortality
KW - Partnership
KW - Women
KW - Communication
KW - Diffusion of innovations
KW - Breast cancer
KW - Health policy
KW - Cancer
KW - Public health
KW - article
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1708526700?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Promotion+Practice&rft.atitle=The+Implementation+Road%3A+Engaging+Community+Partnerships+in+Evidence-Based+Cancer+Control+Interventions&rft.au=Breslau%2C+Erica+S%3BWeiss%2C+Elisa+S%3BWilliams%2C+Abigail%3BBurness%2C+Allison%3BKepka%2C+Deanna&rft.aulast=Breslau&rft.aufirst=Erica&rft.date=2015-01-01&rft.volume=16&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Health+Promotion+Practice&rft.issn=15248399&rft_id=info:doi/10.1177%2F1524839914528705
LA - English
DB - PAIS Index
N1 - Date revised - 2015-09-01
N1 - Last updated - 2016-09-28
N1 - SubjectsTermNotLitGenreText - Partnership; Public health; Women; Mortality; Breast cancer; Diffusion of innovations; Cancer; Health policy; Communication
DO - http://dx.doi.org/10.1177/1524839914528705
ER -
TY - JOUR
T1 - Combined Analysis of SNP Array Data Identifies Novel CNV Candidates and Pathways in Ependymoma and Mesothelioma
AN - 1701500771; PQ0001772704
AB - Copy number variation is a class of structural genomic modifications that includes the gain and loss of a specific genomic region, which may include an entire gene. Many studies have used low-resolution techniques to identify regions that are frequently lost or amplified in cancer. Usually, researchers choose to use proprietary or non-open-source software to detect these regions because the graphical interface tends to be easier to use. In this study, we combined two different open-source packages into an innovative strategy to identify novel copy number variations and pathways associated with cancer. We used a mesothelioma and ependymoma published datasets to assess our tool. We detected previously described and novel copy number variations that are associated with cancer chemotherapy resistance. We also identified altered pathways associated with these diseases, like cell adhesion in patients with mesothelioma and negative regulation of glutamatergic synaptic transmission in ependymoma patients. In conclusion, we present a novel strategy using open-source software to identify copy number variations and altered pathways associated with cancer.
JF - BioMed Research International
AU - Wajnberg, Gabriel
AU - Carvalho, Benilton S
AU - Ferreira, Carlos G
AU - Passetti, Fabio
AD - Bioinformatics Unit, Clinical Research Coordination, National Cancer Institute of Brazil (INCA), 20231-050 Rio de Janeiro, RJ, Brazil, passetti@fiocruz.br
Y1 - 2015/01//
PY - 2015
DA - Jan 2015
PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States
VL - 2015
SN - 2314-6133, 2314-6133
KW - Biotechnology and Bioengineering Abstracts
KW - Data processing
KW - Chemotherapy
KW - Cancer
KW - copy number
KW - Cell adhesion
KW - Computer programs
KW - software
KW - Glutamatergic transmission
KW - Single-nucleotide polymorphism
KW - mesothelioma
KW - genomics
KW - Synaptic transmission
KW - W 30960:Bioinformatics & Computer Applications
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701500771?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+American+Society+for+Cell+Biology+and+International+Federation+for+Cell+Biology+Meeting+%282014+ASCB%2FIFCB%29&rft.atitle=Lipid+exhange+at+contact+sites&rft.au=Prinz%2C+Will&rft.aulast=Prinz&rft.aufirst=Will&rft.date=2014-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+American+Society+for+Cell+Biology+and+International+Federation+for+Cell+Biology+Meeting+%282014+ASCB%2FIFCB%29&rft.issn=&rft_id=info:doi/
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-08-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Computer programs; Glutamatergic transmission; software; Data processing; Single-nucleotide polymorphism; Chemotherapy; mesothelioma; Synaptic transmission; genomics; Cancer; Cell adhesion; copy number
DO - http://dx.doi.org/10.1155/2015/902419
ER -
TY - JOUR
T1 - The Implementation Road: Engaging Community Partnerships in Evidence-Based Cancer Control Interventions
AN - 1683509130
AB - Southern rural and underserved counties have high proportions of individuals with increased mortality for cervical and breast cancers. To improve the integration of behavioral research into practice, the dissemination and implementation of efficacious interventions to encourage the use of screening have increased in recent years. This study addressed gaps in the dissemination and implementation of evidence-based interventions with a pilot called Team Up. Qualitative interviews with 24 key individuals in six state-level partnerships explored partnership characteristics that influenced selection and use of evidence-based interventions among low-income, rarely or never screened women. Guided by diffusion of innovations theory and the Lasker and Weiss partnership functioning model, interviews about the intervention centered on (a) knowledge surrounding evidence base; (b) identification, selection, and adoption; (c) planning and adaptation; (d) implementation; and (e) partnership reflections and impact. Using grounded theory and content analysis, data revealed that lack of communication and high partner turnover hindered adoption and adaptation, whereas failure of partnership leaders to engage local stakeholders and lack of sufficient funds hampered implementation. Delivery of evidence-based interventions was more effective when partnerships included local partners in early decision making and when coaches were introduced to facilitate strategic thinking about translating evidence-based interventions into practice. A challenge for public health partnerships was the translation of interventions into successful programs, such that underserved communities benefited from early detection intervention research.
JF - Health Promotion Practice
AU - Breslau, Erica S
AU - Weiss, Elisa S
AU - Williams, Abigail
AU - Burness, Allison
AU - Kepka, Deanna
AD - National Cancer Institute, Bethesda, MD, USA ; The Leukemia & Lymphoma Society, White Plains, NY, USA ; Mayor’s Office to Combat Domestic Violence, The City of New York, New York, NY, USA ; National Cancer Institute, Bethesda, MD, USA, MedStar Washington Hospital Center, Washington, DC, USA ; National Cancer Institute, Bethesda, MD, USA, University of Utah, Salt Lake City, UT, USA ; National Cancer Institute, Bethesda, MD, USA
Y1 - 2015/01//
PY - 2015
DA - Jan 2015
SP - 46
EP - 54
CY - Thousand Oaks
PB - SAGE PUBLICATIONS, INC.
VL - 16
IS - 1
SN - 1524-8399
KW - Public Health And Safety
KW - cancer prevention and control
KW - health disparities
KW - health education
KW - health promotion
KW - partnerships/coalitions
KW - program planning and evaluation
KW - women’s health
KW - Adaptation
KW - Breast cancer
KW - Cervical cancer
KW - Early warnings
KW - Evidence based
KW - Evidence based medicine
KW - Funds
KW - Grounded theory
KW - Health education
KW - Identification
KW - Innovations
KW - Interventions
KW - Low income people
KW - Low income women
KW - Mortality
KW - Partnerships
KW - Public health
KW - Public health policy
KW - Rural communities
KW - Screening
KW - Behaviour
KW - Cancer
KW - Coalitions
KW - Communication
KW - Content analysis
KW - Decision making
KW - Detection
KW - Dissemination
KW - Early intervention programmes
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+American+Society+for+Cell+Biology+and+International+Federation+for+Cell+Biology+Meeting+%282014+ASCB%2FIFCB%29&rft.atitle=Imaging+the+molecular+architecture+of+the+plasma+membrane+with+correlative+3D+super+resolution+light+and+electron+microscopy&rft.au=Taraska%2C+Justin&rft.aulast=Taraska&rft.aufirst=Justin&rft.date=2014-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+American+Society+for+Cell+Biology+and+International+Federation+for+Cell+Biology+Meeting+%282014+ASCB%2FIFCB%29&rft.issn=&rft_id=info:doi/
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-05-14
N1 - Last updated - 2016-05-13
DO - http://dx.doi.org/10.1177/1524839914528705
ER -
TY - JOUR
T1 - Novel dosing strategies increase exposures of the potent antituberculosis drug rifapentine but are poorly tolerated in healthy volunteers.
AN - 1681266550; 25824215
AB - Rifapentine is a potent antituberculosis drug currently in phase III trials. Bioavailability decreases with increasing dose, yet high daily exposures are likely needed to improve efficacy and shorten the tuberculosis treatment duration. Further, the limits of tolerability are poorly defined. The phase I multicenter trial in healthy adults described here investigated two strategies to increase rifapentine exposures: dividing the dose or giving the drug with a high-fat meal. In arm 1, rifapentine was administered at 10 mg/kg of body weight twice daily and 20 mg/kg once daily, each for 14 days, separated by a 28-day washout; the dosing sequence was randomized. In arm 2, 15 mg/kg rifapentine once daily was given with a high-fat versus a low-fat breakfast. Sampling for pharmacokinetic analysis was performed on days 1 and 14. Population pharmacokinetic analyses were performed. This trial was stopped early for poor tolerability and because of safety concerns. Of 44 subjects, 20 discontinued prematurely; 11 of these discontinued for protocol-defined toxicity (a grade 3 or higher adverse event or grade 2 or higher rifamycin hypersensitivity). Taking rifapentine with a high-fat meal increased the median steady-state area under the concentration-time curve from time zero to 24 h (AUC0-24ss) by 31% (relative standard error, 6%) compared to that obtained when the drug was taken with a low-fat breakfast. Dividing the dose increased exposures substantially (e.g., 38% with 1,500 mg/day). AUC0-24ss was uniformly higher in our study than in recent tuberculosis treatment trials, in which toxicity was rare. In conclusion, two strategies to increase rifapentine exposures, dividing the dose or giving it with a high-fat breakfast, successfully increased exposures, but toxicity was common in healthy adults. The limits of tolerability in patients with tuberculosis remain to be defined. (AIDS Clinical Trials Group study A5311 has been registered at ClinicalTrials.gov under registration no. NCT01574638.).
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
JF - Antimicrobial agents and chemotherapy
AU - Dooley, Kelly E
AU - Savic, Radojka M
AU - Park, Jeong-Gun
AU - Cramer, Yoninah
AU - Hafner, Richard
AU - Hogg, Evelyn
AU - Janik, Jennifer
AU - Marzinke, Mark A
AU - Patterson, Kristine
AU - Benson, Constance A
AU - Hovind, Laura
AU - Dorman, Susan E
AU - Haas, David W
AU - ACTG A5311 Study Team
AD - Johns Hopkins University School of Medicine, Baltimore, Maryland, USA kdooley1@jhmi.edu. ; University of California, San Francisco, California, USA. ; Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts, USA. ; Division of AIDS, National Institutes of Health, Bethesda, Maryland, USA. ; Social & Scientific Systems, Inc., Silver Spring, Maryland, USA. ; Frontier Science Foundation, Amherst, New York, USA. ; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. ; University of North Carolina, Chapel Hill, North Carolina, USA. ; University of California, San Diego, California, USA. ; Vanderbilt University School of Medicine, Nashville, Tennessee, USA. ; ACTG A5311 Study Team
Y1 - 2015
PY - 2015
DA - 2015
SP - 3399
EP - 3405
VL - 59
IS - 6
KW - Antitubercular Agents
KW - 0
KW - Rifampin
KW - VJT6J7R4TR
KW - rifapentine
KW - XJM390A33U
KW - Index Medicus
KW - Young Adult
KW - Drug Administration Schedule
KW - Humans
KW - Adult
KW - Aged
KW - Middle Aged
KW - Healthy Volunteers
KW - Adolescent
KW - Male
KW - Female
KW - Antitubercular Agents -- pharmacokinetics
KW - Rifampin -- analogs & derivatives
KW - Rifampin -- adverse effects
KW - Antitubercular Agents -- administration & dosage
KW - Rifampin -- pharmacokinetics
KW - Rifampin -- administration & dosage
KW - Antitubercular Agents -- adverse effects
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2016-02-16
N1 - Date created - 2015-05-15
N1 - Date revised - 2017-01-14
N1 - Genetic sequence - NCT01574638; ClinicalTrials.gov
N1 - SuppNotes - Cited By:
Medicine (Baltimore). 1999 Nov;78(6):361-9 [10575418]
Antimicrob Agents Chemother. 2012 Aug;56(8):4331-40 [22664964]
MMWR Morb Mortal Wkly Rep. 2003 Aug 8;52(31):735-9 [12904741]
Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S440-50 [6356277]
Clin Pharmacol Ther. 2005 Oct;78(4):342-50 [16198653]
Antimicrob Agents Chemother. 2007 Aug;51(8):2994-6 [17517849]
PLoS Med. 2007 Dec;4(12):e344 [18092886]
Antimicrob Agents Chemother. 2010 Aug;54(8):3390-4 [20516273]
Am J Respir Crit Care Med. 2011 May 1;183(9):1254-61 [21330452]
Int J Tuberc Lung Dis. 2011 Aug;15(8):1133 [21740683]
Antimicrob Agents Chemother. 2011 Sep;55(9):4122-7 [21709081]
J Infect Dis. 2012 Oct 1;206(7):1030-40 [22850121]
Lancet Infect Dis. 2013 Jan;13(1):27-35 [23103177]
Int J Tuberc Lung Dis. 2013 May;17(5):590-6 [23575322]
Antimicrob Agents Chemother. 2014 Jun;58(6):3035-42 [24614383]
Antimicrob Agents Chemother. 2003 Jul;47(7):2118-24 [12821456]
N Engl J Med. 2011 Dec 8;365(23):2155-66 [22150035]
Clin Pharmacol Ther. 2012 May;91(5):881-8 [22472995]
Am J Respir Crit Care Med. 2015 Feb 1;191(3):333-43 [25489785]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1128/AAC.05128-14
ER -
TY - JOUR
T1 - Inositol pyrophosphates: Why so many phosphates?
AN - 1680451541; PQ0001535628
AB - The inositol pyrophosphates (PP-InsPs) are a specialized group of "energetic" signaling molecules found in yeasts, plants and animals. PP-InsPs boast the most crowded three dimensional phosphate arrays found in Nature; multiple phosphates and diphosphates are crammed around the six-carbon, inositol ring. Yet, phosphate esters are also a major energy currency in cells. So the synthesis of PP-InsPs, and the maintenance of their levels in the face of a high rate of ongoing turnover, all requires significant bioenergetic input. What are the particular properties of PP-InsPs that repay this investment of cellular energy? Potential answers to that question are discussed here, against the backdrop of a recent hypothesis that signaling by PP-InsPs is evolutionarily ancient. The latter idea is extended herein, with the proposal that the primordial origins of PP-InsPs is reflected in the apparent lack of isomeric specificity of certain of their actions. Nevertheless, there are other aspects of signaling by these polyphosphates that are more selective for a particular PP-InsP isomer. Consideration of the nature of both specific and non-specific effects of PP-InsPs can help rationalize why such molecules possess so many phosphates.
JF - Advances in Biological Regulation
AU - Shears, Stephen B
AD - Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, USA, Shears@niehs.nih.gov
Y1 - 2015
PY - 2015
DA - 2015
SP - 203
EP - 216
PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom
VL - 57
SN - 2212-4926, 2212-4926
KW - Biotechnology and Bioengineering Abstracts
KW - Inositol pyrophosphates
KW - Structure
KW - Analogs
KW - Diphosphoinositol polyphosphates
KW - Cell-signaling
KW - Kinase
KW - Phosphorylation
KW - Phosphate
KW - Bioenergetics
KW - Energy
KW - Inositol
KW - polyphosphates
KW - Esters
KW - pyrophosphates
KW - Evolution
KW - Isomers
KW - W 30910:Imaging
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680451541?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Biological+Regulation&rft.atitle=Inositol+pyrophosphates%3A+Why+so+many+phosphates%3F&rft.au=Shears%2C+Stephen+B&rft.aulast=Shears&rft.aufirst=Stephen&rft.date=2015-01-01&rft.volume=57&rft.issue=&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Advances+in+Biological+Regulation&rft.issn=22124926&rft_id=info:doi/10.1016%2Fj.jbior.2014.09.015
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-05-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Phosphate; Bioenergetics; Energy; polyphosphates; Inositol; Esters; Evolution; pyrophosphates; Isomers
DO - http://dx.doi.org/10.1016/j.jbior.2014.09.015
ER -
TY - JOUR
T1 - Molecular mechanism behind the synergistic activity of diphenylmethyl selenocyanate and Cisplatin against murine tumor model.
AN - 1677894407; 25584690
AB - Various preclinical, clinical and epidemiological studies have already well established the cancer chemopreventive and chemoprotective potential of selenium compounds. In addition to its protective efficacy, recent studies have also proved the abilities of selenium compounds to induce cell death specifically in malignant cells. Therefore, our intention is to improve the therapeutic efficacy of an alkylating agent, cisplatin, by the adjuvant use of an organoselenium compound, diphenylmethyl selenocyanate (DMSE). It was observed that combined treatment decreased the tumor burden significantly through reactive oxygen species generation and modulation of antioxidant and detoxifying enzyme system in tumor cells. These activities ultimately led to significant DNA damage and apoptosis in tumor cells. Study of the molecular pathway disclosed that the adjuvant treatment caused induction of p53, Bax and suppressed Bcl-2 followed by the activation of caspase cascade. Furthermore, a concomitant decrease in cisplatin-induced nephrotoxicity and hematopoietic toxicity by DMSE might also have enhanced the efficacy of cisplatin and provided survival advantage to the host. Results suggested that the combination treatment with DMSE and cisplatin may offer potential therapeutic benefit, and utilization of cisplatin in cancer chemotherapy exempt of its limitations.
JF - Anti-cancer agents in medicinal chemistry
AU - Chakraborty, Pramita
AU - Roy, Somnath Singha
AU - Bhattacharya, Sudin
AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37- S. P. Mukherjee Road, Kolkata-700026, India. sudinb19572004@yahoo.co.in.
Y1 - 2015
PY - 2015
DA - 2015
SP - 501
EP - 510
VL - 15
IS - 4
KW - Antineoplastic Agents
KW - 0
KW - Organoselenium Compounds
KW - Proto-Oncogene Proteins c-bcl-2
KW - Reactive Oxygen Species
KW - Tumor Suppressor Protein p53
KW - diphenylmethyl selenocyanate
KW - Caspases
KW - EC 3.4.22.-
KW - Cisplatin
KW - Q20Q21Q62J
KW - Index Medicus
KW - Reactive Oxygen Species -- metabolism
KW - Animals
KW - Apoptosis
KW - Enzyme Activation
KW - DNA Damage
KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism
KW - Tumor Burden
KW - Mice
KW - Drug Synergism
KW - Tumor Suppressor Protein p53 -- metabolism
KW - Male
KW - Caspases -- metabolism
KW - Organoselenium Compounds -- pharmacology
KW - Cisplatin -- therapeutic use
KW - Organoselenium Compounds -- therapeutic use
KW - Carcinoma, Ehrlich Tumor -- pathology
KW - Carcinoma, Ehrlich Tumor -- drug therapy
KW - Cisplatin -- pharmacology
KW - Antineoplastic Agents -- therapeutic use
KW - Antineoplastic Agents -- pharmacology
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-12-21
N1 - Date created - 2015-05-01
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
ER -
TY - JOUR
T1 - Targeting the HIV RNA genome: high-hanging fruit only needs a longer ladder.
AN - 1675876016; 25735922
AB - Small molecules targeting the enzymes responsible for human immunodeficiency virus (HIV) maturation, DNA synthesis and its subsequent chromosomal integration as ribonucleotide-free double-stranded DNA remain the mainstay of combination antiretroviral therapy. For infected individuals harboring drug-susceptible virus, this approach has afforded complete or near-complete viral suppression. However, in the absence of a curative strategy, the predictable emergence of drug-resistant variants requires continued development of improved antiviral strategies, inherent to which is the necessity of identifying novel targets. Regulatory elementsRegulatory elements that mediate transcription, translation, nucleocytoplasmic transport, dimerization, packaging and reverse transcription of the (+) strand RNA genomeRNA genome should now be considered viable targets for small molecule, peptide- and oligonucleotide-based therapeuticsTherapeutics . Where target specificity and cellular penetration and toxicity have been the primary obstacle to successful "macromolecule therapeutics", this chapter summarizes (a) novel approaches targeting RNA motifs whose three-dimensional structure is critical for biological function and consequently may be less prone to resistance-conferring mutations and (b) improved methods for deliveryDelivery .
JF - Current topics in microbiology and immunology
AU - Le Grice, Stuart F J
AD - RT Biochemistry Section, Basic Research Laboratory, National Cancer Institute, Frederick, MD, 21702, USA, legrices@mail.nih.gov.
Y1 - 2015
PY - 2015
DA - 2015
SP - 147
EP - 169
VL - 389
SN - 0070-217X, 0070-217X
KW - Anti-HIV Agents
KW - 0
KW - DNA, Viral
KW - RNA, Viral
KW - Viral Proteins
KW - Index Medicus
KW - Virus Assembly
KW - HIV Long Terminal Repeat
KW - DNA, Viral -- biosynthesis
KW - Virus Replication -- drug effects
KW - Active Transport, Cell Nucleus -- drug effects
KW - Humans
KW - Viral Proteins -- biosynthesis
KW - Reverse Transcription -- drug effects
KW - Genome, Viral -- drug effects
KW - Anti-HIV Agents -- pharmacology
KW - RNA, Viral -- drug effects
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-09
N1 - Date created - 2015-04-23
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1007/82_2015_434
ER -
TY - JOUR
T1 - Patterns of non-suicidal self-injurious behaviours among college students in India
AN - 1673612534
AB - Background: Non-suicidal self-injurious behaviour (NSSI) is a growing concern among youth and rarely reaches the attention of mental health and medical services. Aims: The study explored the occurrence, methods, characteristics and reported reasons for NSSI among a sample of college students in India. Methods: A total of 470 participants from undergraduate and postgraduate colleges completed the Functional Assessment of Self Mutilation (FASM) questionnaire. Results: Results indicated that 31.2% of the participants reported NSSI in the past year, with the mean age of onset being 15.9 years. Moderate/severe forms of NSSI were reported by 19.8% of the sample. The most common method was self-hitting (15.2%) followed by cutting or carving skin (13.2%). A majority of self-injurers endorsed multiple methods of NSSI, and there were no significant gender differences in NSSI rates. The NSSI was performed both to regulate internal emotional states (automatic reinforcement) and to influence others in the environment (social reinforcement).The most commonly endorsed reasons for NSSI were ‘to feel relaxed’ and ‘to get control of the situation’, while the least frequently endorsed reasons were ‘to make others angry’ and ‘to avoid college, work, or other activities’. Conclusion: The findings underscore the need to increase the awareness and understanding of NSSIs and to plan targeted interventions among college youth.
JF - The International Journal of Social Psychiatry
AU - Kharsati, Naphisabet
AU - Bhola, Poornima
AD - SAN-KER Hospital, Department of Clinical Psychology, Shillong, India ; Department of Clinical Psychology, National Institute of Mental Health and Neuro Sciences, Bangalore, India ; SAN-KER Hospital, Department of Clinical Psychology, Shillong, India
Y1 - 2015/01//
PY - 2015
DA - Jan 2015
SP - 39
EP - 49
CY - London
PB - SAGE PUBLICATIONS, INC.
VL - 61
IS - 1
SN - 0020-7640
KW - Medical Sciences--Psychiatry And Neurology
KW - Non-suicidal self-injurious behaviours
KW - self-harm
KW - cutting
KW - youth
KW - college
KW - community
KW - Suicidal behaviour
KW - Undergraduate students
KW - India
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LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-03-24
N1 - Last updated - 2016-09-07
N1 - SubjectsTermNotLitGenreText - India
DO - http://dx.doi.org/10.1177/0020764014535755
ER -
TY - JOUR
T1 - The Design of Covalent Allosteric Drugs
AN - 1668254088; PQ0001286074
AB - A key issue in drug discovery is how to reduce drug dosage and increase specificity while retaining or increasing efficacy, as high dosage is often linked to toxicity. There are two types of drugs on the market: orthosteric and allosteric. Orthosteric drugs can be noncovalent or covalent. The latter are advantageous because they may be prescribed in lower doses, but their potential off-target toxicity is a primary concern. The chief advantages of allosteric drugs are their higher specificity and their consequently lower chance of toxic side effects. Covalent allosteric drugs combine the pharmacological merits of covalent drugs with the additional benefit of the higher specificity of allosteric drugs. In a recent promising step in therapeutic drug development, allosteric, disulfide-tethered fragments successfully modulated the activity of a protein kinase and K-Ras.
JF - Annual Review of Pharmacology and Toxicology
AU - Nussinov, Ruth
AU - Tsai, Chung-Jung
AD - Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland 21702; Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel, NussinoR@helix.nih.gov
Y1 - 2015///0,
PY - 2015
DA - 0, 2015
SP - 249
EP - 267
PB - Annual Reviews, Inc., 4139 El Camino Way Palo Alto CA 94303-0139 United States
VL - 55
SN - 0362-1642, 0362-1642
KW - Toxicology Abstracts
KW - allosteric modulator
KW - agonist
KW - antagonist
KW - pharmacology
KW - toxicity
KW - allosteric drug discovery
KW - K-Ras protein
KW - Drug discovery
KW - Allosteric properties
KW - Reviews
KW - Drug development
KW - Toxicity
KW - Drugs
KW - Side effects
KW - X 24310:Pharmaceuticals
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-03-01
N1 - Last updated - 2016-03-17
N1 - SubjectsTermNotLitGenreText - Drug discovery; K-Ras protein; Reviews; Allosteric properties; Drug development; Toxicity; Drugs; Side effects
DO - http://dx.doi.org/10.1146/annurev-pharmtox-010814-124401
ER -
TY - JOUR
T1 - Is Visual Registration Equivalent to Semiautomated Registration in Prostate Biopsy?
AN - 1668253471; PQ0001292482
AB - In magnetic resonance iimaging- (MRI-) ultrasound (US) guided biopsy, suspicious lesions are identified on MRI, registered on US, and targeted during biopsy. The registration can be performed either by a human operator (visual registration) or by fusion software. Previous studies showed that software registration is fairly accurate in locating suspicious lesions and helps to improve the cancer detection rate. Here, the performance of visual registration was examined for ability to locate suspicious lesions defined on MRI. This study consists of 45 patients. Two operators with differing levels of experience (<1 and 18 years) performed visual registration. The overall spatial difference by the two operators in 72 measurements was 10.6 plus or minus 6.0 mm. Each operator showed a spatial difference of 9.4 plus or minus 5.1 mm (experienced; 39 lesions) and 12.1 plus or minus 6.6 mm (inexperienced; 33 lesions), respectively. In a head-to-head comparison of the same 16 lesions from 12 patients, the spatial differences were 9.7 mm plus or minus 4.9 mm (experienced) and 13.4 mm plus or minus 7.4 mm (inexperienced). There were significant differences between the two operators (unpaired, P value = 0.042; paired, P value = 0.044). The substantial differences by the two operators suggest that visual registration could improperly and inaccurately target many tumors, thereby potentially leading to missed diagnosis or false characterization on pathology.
JF - BioMed Research International
AU - Kwak, Jin Tae
AU - Hong, Cheng William
AU - Pinto, Peter A
AU - Williams, Molly
AU - Xu, Sheng
AU - Kruecker, Jochen
AU - Yan, Pingkun
AU - Turkbey, Baris
AU - Choyke, Peter L
AU - Wood, Bradford J
AD - Center for Interventional Oncology, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA, bwood@cc.nih.gov
Y1 - 2015/01//
PY - 2015
DA - Jan 2015
PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States
VL - 2015
SN - 2314-6133, 2314-6133
KW - Biotechnology and Bioengineering Abstracts
KW - Computer programs
KW - software
KW - Magnetic resonance imaging
KW - Biopsy
KW - N.M.R.
KW - Tumors
KW - Ultrasound
KW - Prostate
KW - Cancer
KW - W 30910:Imaging
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668253471?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Is+Visual+Registration+Equivalent+to+Semiautomated+Registration+in+Prostate+Biopsy%3F&rft.au=Kwak%2C+Jin+Tae%3BHong%2C+Cheng+William%3BPinto%2C+Peter+A%3BWilliams%2C+Molly%3BXu%2C+Sheng%3BKruecker%2C+Jochen%3BYan%2C+Pingkun%3BTurkbey%2C+Baris%3BChoyke%2C+Peter+L%3BWood%2C+Bradford+J&rft.aulast=Kwak&rft.aufirst=Jin&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F394742
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-03-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Computer programs; software; Magnetic resonance imaging; N.M.R.; Biopsy; Tumors; Prostate; Ultrasound; Cancer
DO - http://dx.doi.org/10.1155/2015/394742
ER -
TY - JOUR
T1 - Measuring Outcome Expectancy Value of Leisure-Time Physical Activity for African Americans
AN - 1665150732
AB - A scale was adapted from existing scales to measure the outcome expectancy value (EV) as one of contributory factors to leisure-time physical activity (LTPA) and was administered to 649 African American adults. The eligible participants (N = 569) for the analysis were split into three subsamples (rate = 0.5 : 0.25 : 0.25) respectively for Exploratory Factor Analysis (N = 285) and cross-validation (N = 142 for the calibration group and N = 142 for the validation group) to evaluate the psychometric properties of the scale. Item analysis of the scale provided adequate psychometric properties. The 2-factor solution with positive and negative outcome EV subscales was supported based on the exploratory factor analysis and the multiple-group confirmatory factor analysis for both the calibration and validation samples. The results support the factorial construct validity and criterion validity of the outcome EV scale applied to assess LTPA in a sample of church-going African Americans.
JF - Behavioral Medicine
AU - Li, Kaigang
AU - Seo, Dong-Chul
AU - Torabi, Mohammad R
AD - National Institute of Child Health and Human Development, Ewha Womans University, College of Health Sciences, Indiana University School of Public Health-Bloomington ; National Institute of Child Health and Human Development; Ewha Womans University, College of Health Sciences; Indiana University School of Public Health-Bloomington
Y1 - 2015/01//
PY - 2015
DA - Jan 2015
SP - 33
EP - 39
CY - Washington
PB - Taylor & Francis Ltd.
VL - 41
IS - 1
SN - 0896-4289
KW - Psychology
KW - American people
KW - Analysis
KW - Leisure activities
KW - Time use
KW - Black American people
KW - Confirmatory factor analysis
KW - Construct validity
KW - Exploratory factor analysis
KW - Factor analysis
KW - Leisure
KW - Physical activity
KW - Psychometric properties
KW - Validation
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665150732?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Medicine&rft.atitle=Measuring+Outcome+Expectancy+Value+of+Leisure-Time+Physical+Activity+for+African+Americans&rft.au=Li%2C+Kaigang%3BSeo%2C+Dong-Chul%3BTorabi%2C+Mohammad+R&rft.aulast=Li&rft.aufirst=Kaigang&rft.date=2015-01-01&rft.volume=41&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Behavioral+Medicine&rft.issn=08964289&rft_id=info:doi/10.1080%2F08964289.2014.881775
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-01-09
N1 - Last updated - 2016-05-13
DO - http://dx.doi.org/10.1080/08964289.2014.881775
ER -
TY - JOUR
T1 - Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells
AN - 1664207399; PQ0001182263
AB - Interleukin-15 (IL-15) is a common gamma -chain cytokine that has a significant role in the activation and proliferation of T and NK cells and holds great potential in fighting infection and cancer. We have previously shown that bioactive IL-15 in vivo comprises a complex of the IL-15 chain with the soluble or cell-associated IL-15 receptor alpha (IL-15R alpha ) chain, which together form the IL-15 heterodimer. We have generated DNA vectors expressing the heterodimeric IL-15 by optimizing mRNA expression and protein trafficking. Repeated administration of these DNA plasmids by intramuscular injection followed by in vivo electroporation in rhesus macaques resulted in sustained high levels of IL-15 in plasma, with no significant toxicity. Administration of DNAs expressing heterodimeric IL-15 also resulted in an increased frequency of NK and T cells undergoing proliferation in peripheral blood. Heterodimeric IL-15 led to preferential expansion of CD8 super(+)NK cells, all memory CD8 super(+) T-cell subsets and effector memory CD4 super(+) T cells. Expression of heterodimeric IL-15 by DNA delivery to the muscle is an efficient procedure to obtain high systemic levels of bioactive cytokine, without the toxicity linked to the high transient cytokine peak associated with protein injection.
JF - Gene Therapy
AU - Bergamaschi, C
AU - Kulkarni, V
AU - Rosati, M
AU - Alicea, C
AU - Jalah, R
AU - Chen, S
AU - Bear, J
AU - Sardesai, N Y
AU - Valentin, A
AU - Felber, B K
AU - Pavlakis, G N
AD - Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA
Y1 - 2015/01//
PY - 2015
DA - Jan 2015
SP - 76
EP - 86
PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom
VL - 22
IS - 1
SN - 0969-7128, 0969-7128
KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW - Protein transport
KW - Interleukin 15 receptors
KW - Gene therapy
KW - Electroporation
KW - Immunological memory
KW - Memory cells
KW - Natural killer cells
KW - Muscles
KW - Peripheral blood
KW - Toxicity
KW - CD8 antigen
KW - Infection
KW - Plasmids
KW - Cancer
KW - Gene expression
KW - Expression vectors
KW - CD4 antigen
KW - Interleukin 15
KW - Lymphocytes T
KW - DNA
KW - Macaca mulatta
KW - Cell proliferation
KW - G 07720:Immunogenetics
KW - W 30905:Medical Applications
KW - N 14810:Methods
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664207399?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Intramuscular+delivery+of+heterodimeric+IL-15+DNA+in+macaques+produces+systemic+levels+of+bioactive+cytokine+inducing+proliferation+of+NK+and+T+cells&rft.au=Bergamaschi%2C+C%3BKulkarni%2C+V%3BRosati%2C+M%3BAlicea%2C+C%3BJalah%2C+R%3BChen%2C+S%3BBear%2C+J%3BSardesai%2C+N+Y%3BValentin%2C+A%3BFelber%2C+B+K%3BPavlakis%2C+G+N&rft.aulast=Bergamaschi&rft.aufirst=C&rft.date=2015-01-01&rft.volume=22&rft.issue=1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2014.84
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-03-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Protein transport; Interleukin 15 receptors; Electroporation; Gene therapy; Muscles; Natural killer cells; Memory cells; Immunological memory; Peripheral blood; CD8 antigen; Toxicity; Plasmids; Infection; Cancer; Expression vectors; Gene expression; CD4 antigen; Interleukin 15; DNA; Lymphocytes T; Cell proliferation; Macaca mulatta
DO - http://dx.doi.org/10.1038/gt.2014.84
ER -
TY - JOUR
T1 - Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach?
AN - 1657315530; 25499450
AB - Primary mediastinal B-cell lymphoma (PMBL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that is putatively derived from a thymic B cell. Accounting for up to 10% of cases of DLBCL, this subtype predominantly affects women in the third and fourth decades of life. Its clinical and molecular characteristics are distinct from other subtypes of DLBCL and, in fact, closely resemble those of nodular sclerosing Hodgkin lymphoma (NSHL). Recently, mediastinal lymphomas with features intermediate between PMBL and NSHL, called mediastinal gray-zone lymphomas, have been described. The optimal management of PMBL is controversial, and most standard approaches include a combination of immunochemotherapy and mediastinal radiation. Recently, the recognition that mediastinal radiation is associated with significant long-term toxicities has led to the development of novel approaches for PMBL that have shown excellent efficacy and challenge the need for routine mediastinal radiation.
JF - Blood
AU - Dunleavy, Kieron
AU - Wilson, Wyndham H
AD - Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.
Y1 - 2015/01/01/
PY - 2015
DA - 2015 Jan 01
SP - 33
EP - 39
VL - 125
IS - 1
KW - Antibodies, Monoclonal, Murine-Derived
KW - 0
KW - Fluorodeoxyglucose F18
KW - 0Z5B2CJX4D
KW - Rituximab
KW - 4F4X42SYQ6
KW - Abridged Index Medicus
KW - Index Medicus
KW - Positron-Emission Tomography
KW - B-Lymphocytes -- cytology
KW - Fluorodeoxyglucose F18 -- chemistry
KW - Humans
KW - Decision Making
KW - Hodgkin Disease -- therapy
KW - Recurrence
KW - Mediastinum -- radiation effects
KW - Immunotherapy -- methods
KW - Gene Expression Profiling
KW - Antibodies, Monoclonal, Murine-Derived -- therapeutic use
KW - Treatment Outcome
KW - Drug Therapy -- methods
KW - Lymphoma -- metabolism
KW - Immunophenotyping
KW - Male
KW - Female
KW - Lymphoma, B-Cell -- therapy
KW - Mediastinal Neoplasms -- therapy
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1657315530?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Primary+mediastinal+B-cell+lymphoma+and+mediastinal+gray+zone+lymphoma%3A+do+they+require+a+unique+therapeutic+approach%3F&rft.au=Dunleavy%2C+Kieron%3BWilson%2C+Wyndham+H&rft.aulast=Dunleavy&rft.aufirst=Kieron&rft.date=2015-01-01&rft.volume=125&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2014-05-575092
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-03-13
N1 - Date created - 2015-01-02
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1182/blood-2014-05-575092
ER -
TY - JOUR
T1 - Successful Protection against Tularemia in C57BL/6 Mice Is Correlated with Expansion of Francisella tularensis-Specific Effector T Cells
AN - 1654694323; 21328243
AB - Francisella tularensis is an intracellular, Gram-negative bacterium that causes the fatal disease tularemia. Currently, there are no licensed vaccines for tularemia and the requirements for protection against infection are poorly defined. To identify correlates of vaccine-induced immunity against tularemia, we compared different strains of the live vaccine strain (LVS) for their relative levels of virulence and ability to protect C57BL/6 mice against challenge with virulent F. tularensis strain SchuS4. Successful vaccination, as defined by survival of C57BL/6 mice, was correlated with significantly greater numbers of effector T cells in the spleen and lung. Further, lung cells and splenocytes from fully protected animals were more effective than lung cells and splenocytes from vaccinated but nonimmune animals in limiting intracellular replication of SchuS4 in vitro. Together, our data provide a unique model to compare efficacious vaccines to nonefficacious vaccines, which will enable comprehensive identification of host and bacterial components required for immunization against tularemia.
JF - Clinical and Vaccine Immunology
AU - Griffin, Amanda J
AU - Crane, Deborah D
AU - Wehrly, Tara D
AU - Bosio, Catharine M
Y1 - 2015/01//
PY - 2015
DA - Jan 2015
SP - 119
EP - 128
PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States
VL - 22
IS - 1
SN - 1556-6811, 1556-6811
KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW - Cell survival
KW - Data processing
KW - Replication
KW - Animal models
KW - Spleen
KW - Francisella tularensis
KW - Infection
KW - Effector cells
KW - Virulence
KW - Splenocytes
KW - Tularemia
KW - Lung
KW - Lymphocytes T
KW - Vaccines
KW - F 06905:Vaccines
KW - J 02350:Immunology
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654694323?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Successful+Protection+against+Tularemia+in+C57BL%2F6+Mice+Is+Correlated+with+Expansion+of+Francisella+tularensis-Specific+Effector+T+Cells&rft.au=Griffin%2C+Amanda+J%3BCrane%2C+Deborah+D%3BWehrly%2C+Tara+D%3BBosio%2C+Catharine+M&rft.aulast=Griffin&rft.aufirst=Amanda&rft.date=2015-01-01&rft.volume=22&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00648-14
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-02-01
N1 - Number of references - 43
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Cell survival; Data processing; Replication; Animal models; Spleen; Infection; Effector cells; Virulence; Splenocytes; Tularemia; Lung; Lymphocytes T; Vaccines; Francisella tularensis
DO - http://dx.doi.org/10.1128/CVI.00648-14
ER -
TY - JOUR
T1 - The role of the microbiota in inflammation, carcinogenesis, and cancer therapy
AN - 1654692061; 21333270
AB - Commensal microorganisms colonize barrier surfaces of all multicellular organisms, including those of humans. For more than 500 million years, commensal microorganisms and their hosts have coevolved and adapted to each other. As a result, the commensal microbiota affects many immune and nonimmune functions of their hosts, and de facto the two together comprise one metaorganism. The commensal microbiota communicates with the host via biologically active molecules. Recently, it has been reported that microbial imbalance may play a critical role in the development of multiple diseases, such as cancer, autoimmune conditions, and increased susceptibility to infection. In this review, we focus on the role of the commensal microbiota in the development, progression, and immune evasion of cancer, as well as some modulatory effects on the treatment of cancer. In particular, we discuss the mechanisms of microbiota-mediated regulation of innate and adaptive immune responses to tumors, and the consequences on cancer progression and whether tumors subsequently become resistant or susceptible to different anticancer therapeutic regiments.
JF - European Journal of Immunology
AU - Dzutsev, Amiran
AU - Goldszmid, Romina S
AU - Viaud, Sophie
AU - Zitvogel, Laurence
AU - Trinchieri, Giorgio
AD - Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 17
EP - 31
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 45
IS - 1
SN - 0014-2980, 0014-2980
KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts
KW - Carcinogenesis
KW - Autoimmune diseases
KW - Commensals
KW - Microorganisms
KW - Tumors
KW - Immune response
KW - Infection
KW - Cancer
KW - Inflammation
KW - A 01340:Antibiotics & Antimicrobials
KW - F 06915:Cancer Immunology
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654692061?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Immunology&rft.atitle=The+role+of+the+microbiota+in+inflammation%2C+carcinogenesis%2C+and+cancer+therapy&rft.au=Dzutsev%2C+Amiran%3BGoldszmid%2C+Romina+S%3BViaud%2C+Sophie%3BZitvogel%2C+Laurence%3BTrinchieri%2C+Giorgio&rft.aulast=Dzutsev&rft.aufirst=Amiran&rft.date=2015-01-01&rft.volume=45&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Immunology&rft.issn=00142980&rft_id=info:doi/10.1002%2Feji.201444972
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-02-01
N1 - Last updated - 2016-04-29
N1 - SubjectsTermNotLitGenreText - Autoimmune diseases; Carcinogenesis; Microorganisms; Commensals; Immune response; Tumors; Infection; Cancer; Inflammation
DO - http://dx.doi.org/10.1002/eji.201444972
ER -
TY - JOUR
T1 - Estimates of benefits and harms of prophylactic use of aspirin in the general population.
AN - 1652449494; 25096604
AB - Accumulating evidence supports an effect of aspirin in reducing overall cancer incidence and mortality in the general population. We reviewed current data and assessed the benefits and harms of prophylactic use of aspirin in the general population.
The effect of aspirin for site-specific cancer incidence and mortality, cardiovascular events was collated from the most recent systematic reviews. Studies identified through systematic Medline search provided data regarding harmful effects of aspirin and baseline rates of harms like gastrointestinal bleeding and peptic ulcer. The effects of aspirin on cancer are not apparent until at least 3 years after the start of use, and some benefits are sustained for several years after cessation in long-term users. No differences between low and standard doses of aspirin are observed, but there were no direct comparisons. Higher doses do not appear to confer additional benefit but increase toxicities. Excess bleeding is the most important harm associated with aspirin use, and its risk and fatality rate increases with age. For average-risk individuals aged 50-65 years taking aspirin for 10 years, there would be a relative reduction of between 7% (women) and 9% (men) in the number of cancer, myocardial infarction or stroke events over a 15-year period and an overall 4% relative reduction in all deaths over a 20-year period.
Prophylactic aspirin use for a minimum of 5 years at doses between 75 and 325 mg/day appears to have favourable benefit-harm profile; longer use is likely to have greater benefits. Further research is needed to determine the optimum dose and duration of use, to identify individuals at increased risk of bleeding, and to test effectiveness of Helicobacter pylori screening-eradication before starting aspirin prophylaxis. © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology.
JF - Annals of oncology : official journal of the European Society for Medical Oncology
AU - Cuzick, J
AU - Thorat, M A
AU - Bosetti, C
AU - Brown, P H
AU - Burn, J
AU - Cook, N R
AU - Ford, L G
AU - Jacobs, E J
AU - Jankowski, J A
AU - La Vecchia, C
AU - Law, M
AU - Meyskens, F
AU - Rothwell, P M
AU - Senn, H J
AU - Umar, A
AD - Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK j.cuzick@qmul.ac.uk. ; Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK. ; Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy. ; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, USA. ; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK. ; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston. ; Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda. ; Epidemiology Research Program, American Cancer Society, Atlanta, USA. ; Centre for Biomedical Research-Translational and Stratified Medicine, Peninsula Schools of Medicine and Dentistry, Plymouth University, Plymouth Centre for Digestive Diseases, Blizard Institute of Cell and Molecular Science, Queen Mary University of London, London, UK. ; Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. ; Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK. ; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, USA. ; Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK. ; Tumor and Breast Center ZeTuP, St Gallen, Switzerland. ; Gastrointestinal and Other Cancers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, USA.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 47
EP - 57
VL - 26
IS - 1
KW - Anti-Inflammatory Agents, Non-Steroidal
KW - 0
KW - Aspirin
KW - R16CO5Y76E
KW - Index Medicus
KW - aspirin
KW - benefit-harm
KW - cardiovascular disease
KW - prevention
KW - gastrointestinal bleeding
KW - cancer
KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use
KW - Humans
KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects
KW - Gastrointestinal Hemorrhage -- chemically induced
KW - Male
KW - Female
KW - Aspirin -- adverse effects
KW - Aspirin -- therapeutic use
KW - Neoplasms -- prevention & control
KW - Stroke -- prevention & control
KW - Myocardial Infarction -- prevention & control
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652449494?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.atitle=Estimates+of+benefits+and+harms+of+prophylactic+use+of+aspirin+in+the+general+population.&rft.au=Cuzick%2C+J%3BThorat%2C+M+A%3BBosetti%2C+C%3BBrown%2C+P+H%3BBurn%2C+J%3BCook%2C+N+R%3BFord%2C+L+G%3BJacobs%2C+E+J%3BJankowski%2C+J+A%3BLa+Vecchia%2C+C%3BLaw%2C+M%3BMeyskens%2C+F%3BRothwell%2C+P+M%3BSenn%2C+H+J%3BUmar%2C+A&rft.aulast=Cuzick&rft.aufirst=J&rft.date=2015-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+American+Society+for+Cell+Biology+and+International+Federation+for+Cell+Biology+Meeting+%282014+ASCB%2FIFCB%29&rft.issn=&rft_id=info:doi/
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-08-24
N1 - Date created - 2014-12-18
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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Comment In:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/annonc/mdu225
ER -
TY - JOUR
T1 - The evolving field of kinase inhibitors in thyroid cancer.
AN - 1652441542; 25240824
AB - Most of the genetic events implicated in the pathogenesis of thyroid cancer (TC) involve genes with kinase activity. Thus, kinase inhibitors (KIs) are very relevant in this field. KIs are considered the most suitable treatment for patients with iodine-refractory differentiated TC; these patients comprise the subgroup with the poorer prognosis. To date, only sorafenib has been approved for this indication, but promising results have been reported with several other KIs. In particular, lenvatinib has demonstrated excellent efficacy, with both progression-free survival and objective tumour response being better than with sorafenib. Despite being considered to be well tolerated, both sorafenib and lenvatinib have shown a remarkable toxicity, which has led to dose reductions in the majority of patients and to treatment discontinuation in a significant proportion of cases. The role of KIs in differentiated TC may be revolutionised by the finding that selumetinib may restore a clinical response to radioactive iodine (RAI). Vandetanib and cabozantinib have been approved for the treatment of advanced, progressive medullary TC (MTC). Nevertheless, the toxicity of both compounds suggests their selective use in those patients with strong disease progression. Treatment with the mTOR-inhibitor everolimus, alone or in combination with somatostatin analogues, should be studied in metastatic MTC patients with slow progression of disease, these representing the vast majority of patients. KIs did not significantly impact on the clinical features of anaplastic TC (ATC). Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
JF - Critical reviews in oncology/hematology
AU - Marotta, V
AU - Sciammarella, C
AU - Vitale, M
AU - Colao, A
AU - Faggiano, A
AD - Department of Clinical Medicine and Surgery, Section of Endocrinology, Federico II University of Naples, Italy. Electronic address: vinc.endo@libero.it. ; Department of Clinical Medicine and Surgery, Section of Endocrinology, Federico II University of Naples, Italy. ; Department of Medicine and Surgery, University of Salerno, Baronissi, Italy. ; Department of Clinical Medicine and Surgery, Section of Endocrinology, Federico II University of Naples, Italy; Endocrinology, National Cancer Institute, Fondazione G. Pascale, Naples, Italy.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 60
EP - 73
VL - 93
IS - 1
KW - Angiogenesis Inhibitors
KW - 0
KW - Anilides
KW - Antineoplastic Agents
KW - Phenylurea Compounds
KW - Piperidines
KW - Protein Kinase Inhibitors
KW - Pyridines
KW - Quinazolines
KW - Quinolines
KW - cabozantinib
KW - 1C39JW444G
KW - Niacinamide
KW - 25X51I8RD4
KW - sorafenib
KW - 9ZOQ3TZI87
KW - lenvatinib
KW - EE083865G2
KW - N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine
KW - YO460OQ37K
KW - Index Medicus
KW - Kinase inhibitors
KW - Cancer therapy
KW - Anti-angiogenetic therapy
KW - Protein kinases
KW - Thyroid cancer
KW - Piperidines -- therapeutic use
KW - Anilides -- therapeutic use
KW - Niacinamide -- therapeutic use
KW - Quinolines -- therapeutic use
KW - Humans
KW - Quinazolines -- therapeutic use
KW - Phenylurea Compounds -- therapeutic use
KW - Niacinamide -- analogs & derivatives
KW - Pyridines -- therapeutic use
KW - Angiogenesis Inhibitors -- therapeutic use
KW - Protein Kinase Inhibitors -- therapeutic use
KW - Thyroid Neoplasms -- drug therapy
KW - Antineoplastic Agents -- therapeutic use
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+oncology%2Fhematology&rft.atitle=The+evolving+field+of+kinase+inhibitors+in+thyroid+cancer.&rft.au=Marotta%2C+V%3BSciammarella%2C+C%3BVitale%2C+M%3BColao%2C+A%3BFaggiano%2C+A&rft.aulast=Marotta&rft.aufirst=V&rft.date=2015-01-01&rft.volume=93&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+oncology%2Fhematology&rft.issn=1879-0461&rft_id=info:doi/10.1016%2Fj.critrevonc.2014.08.007
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-29
N1 - Date created - 2014-12-16
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.critrevonc.2014.08.007
ER -
TY - JOUR
T1 - Nontargeted SWATH acquisition for identifying 47 synthetic cannabinoid metabolites in human urine by liquid chromatography-high-resolution tandem mass spectrometry.
AN - 1652427170; 25224637
AB - Clandestine laboratories constantly produce new synthetic cannabinoids to circumvent legislative scheduling efforts, challenging and complicating toxicological analysis. Sundstrom et al. (Anal Bioanal Chem 405(26):8463-8474, [9]) and Kronstrand et al. (Anal Bioanal Chem 406(15):3599-3609, [10]) published nontargeted liquid chromatography, high-resolution, quadrupole/time-of-flight mass spectrometric (LC-QTOF) assays with validated detection of 18 and 38 urinary synthetic cannabinoid metabolites, respectively. We developed and validated a LC-QTOF urine method for simultaneously identifying the most current 47 synthetic cannabinoid metabolites from 21 synthetic cannabinoid families (5-fluoro AB-PINACA, 5-fluoro-AKB48, 5-fluoro PB-22, AB-PINACA, ADB-PINACA, AKB48, AM2201, JWH-018, JWH-019, JWH-073, JWH-081, JWH-122, JWH-200, JWH-210, JWH-250, JWH-398, MAM2201, PB-22, RCS-4, UR-144, and XLR11). β-Glucuronidase-hydrolyzed urine was extracted with 1-mL Biotage SLE+ columns. Specimens were reconstituted in 150-μL mobile phase consisting of 80% A (0.1% formic acid in water) and 20% B (0.1% formic acid in acetonitrile). Fifty microliters was injected, and SWATH™ MS data were acquired in positive electrospray mode. The LC-QTOF instrument consisted of a Shimadzu UFLCxr system and an ABSciex 5600+ TripleTOF® mass spectrometer. Gradient chromatographic separation was achieved with a Restek Ultra Biphenyl column with a 0.5-mL/min flow rate and an overall run time of 15 min. Identification criteria included molecular ion mass error, isotopic profiles, retention time, and library fit criteria. Limits of detection were 0.25-5 μg/L (N = 10 unique fortified urine samples), except for two PB-22 metabolites with limits of 10 and 20 μg/L. Extraction efficiencies and matrix effects (N = 10) were 55-104 and -65-107%, respectively. We present a highly useful novel LC-QTOF method for simultaneously confirming 47 synthetic cannabinoid metabolites in human urine.
JF - Analytical and bioanalytical chemistry
AU - Scheidweiler, Karl B
AU - Jarvis, Michael J Y
AU - Huestis, Marilyn A
AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard Suite 200 Room 05A-721, Baltimore, MD, 21224, USA.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 883
EP - 897
VL - 407
IS - 3
KW - (1-hexyl-1H-indol-3-yl)-1-naphthalenylmethanone
KW - 0
KW - (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
KW - (4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone
KW - 1-(1- pentyl-1H-indol-3-yl)-2-(2-methoxyphenyl)ethanone
KW - 1-(5-fluoropentyl)-3-(1-naphthoyl)indole
KW - 1-pentyl-3-(1-naphthoyl)indole
KW - 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone
KW - Anisoles
KW - Cannabinoids
KW - Indazoles
KW - Indoles
KW - JWH-073
KW - N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide
KW - Naphthalenes
KW - Index Medicus
KW - Sensitivity and Specificity
KW - Indazoles -- urine
KW - Signal Processing, Computer-Assisted
KW - Indoles -- urine
KW - Humans
KW - Calibration
KW - Anisoles -- urine
KW - Naphthalenes -- urine
KW - Limit of Detection
KW - Hydrolysis
KW - Substance Abuse Detection -- methods
KW - Chromatography, Liquid -- methods
KW - Cannabinoids -- metabolism
KW - Tandem Mass Spectrometry -- methods
KW - Cannabinoids -- urine
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-10-02
N1 - Date created - 2015-01-24
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1007/s00216-014-8118-8
ER -
TY - JOUR
T1 - Recognition and repair of chemically heterogeneous structures at DNA ends.
AN - 1652415166; 25111769
AB - Exposure to environmental toxicants and stressors, radiation, pharmaceutical drugs, inflammation, cellular respiration, and routine DNA metabolism all lead to the production of cytotoxic DNA strand breaks. Akin to splintered wood, DNA breaks are not "clean." Rather, DNA breaks typically lack DNA 5'-phosphate and 3'-hydroxyl moieties required for DNA synthesis and DNA ligation. Failure to resolve damage at DNA ends can lead to abnormal DNA replication and repair, and is associated with genomic instability, mutagenesis, neurological disease, ageing and carcinogenesis. An array of chemically heterogeneous DNA termini arises from spontaneously generated DNA single-strand and double-strand breaks (SSBs and DSBs), and also from normal and/or inappropriate DNA metabolism by DNA polymerases, DNA ligases and topoisomerases. As a front line of defense to these genotoxic insults, eukaryotic cells have accrued an arsenal of enzymatic first responders that bind and protect damaged DNA termini, and enzymatically tailor DNA ends for DNA repair synthesis and ligation. These nucleic acid transactions employ direct damage reversal enzymes including Aprataxin (APTX), Polynucleotide kinase phosphatase (PNK), the tyrosyl DNA phosphodiesterases (TDP1 and TDP2), the Ku70/80 complex and DNA polymerase β (POLβ). Nucleolytic processing enzymes such as the MRE11/RAD50/NBS1/CtIP complex, Flap endonuclease (FEN1) and the apurinic endonucleases (APE1 and APE2) also act in the chemical "cleansing" of DNA breaks to prevent genomic instability and disease, and promote progression of DNA- and RNA-DNA damage response (DDR and RDDR) pathways. Here, we provide an overview of cellular first responders dedicated to the detection and repair of abnormal DNA termini. © 2014 Wiley Periodicals, Inc.
JF - Environmental and molecular mutagenesis
AU - Andres, Sara N
AU - Schellenberg, Matthew J
AU - Wallace, Bret D
AU - Tumbale, Percy
AU - Williams, R Scott
AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, North Carolina.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 1
EP - 21
VL - 56
IS - 1
KW - DNA
KW - 9007-49-2
KW - Index Medicus
KW - X-ray crystallography
KW - DNA damage response
KW - neurodegeneration
KW - cancer
KW - Animals
KW - Genomic Instability
KW - Humans
KW - Disease Progression
KW - Nucleic Acid Conformation
KW - DNA Repair -- genetics
KW - DNA -- genetics
KW - DNA -- chemistry
KW - DNA Damage -- genetics
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Recognition+and+repair+of+chemically+heterogeneous+structures+at+DNA+ends.&rft.au=Andres%2C+Sara+N%3BSchellenberg%2C+Matthew+J%3BWallace%2C+Bret+D%3BTumbale%2C+Percy%3BWilliams%2C+R+Scott&rft.aulast=Andres&rft.aufirst=Sara&rft.date=2015-01-01&rft.volume=56&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.21892
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-03-19
N1 - Date created - 2015-01-21
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1002/em.21892
ER -
TY - JOUR
T1 - Withdrawal from long-term methamphetamine self-administration 'normalizes' neurometabolites in rhesus monkeys: a super(1)H MR spectroscopy study
AN - 1647024729; 21213421
AB - super(1)H magnetic resonance spectroscopy has demonstrated alterations in several neurometabolites in methamphetamine (METH)-dependent individuals in brain regions implicated in addiction. Yet, it is unclear whether these neurochemicals return to homeostatic levels after an individual abstains from drug use, a difficult question to address due to high recidivism and poor study retention in human subjects. We thus utilized a non-human primate model of addiction to explore the effects of long-term drug exposure and withdrawal on brain neurochemistry. Ten rhesus macaque monkeys on an active METH self-administration protocol (average use 4.6 plus or minus 0.8 years, average daily intake between 0.4 and 1.2mg/kg) and 10 age- and sex-matched drug-naive controls (CONT) served as subjects. Concentrations of several neurochemicals were evaluated at several timepoints following withdrawal from drug availability (10 monkeys at 1 week and 1 and 3 months, and 6 monkeys at 6 and 12 months; CONT examined at one timepoint). At 1 week following METH withdrawal, we found increases in myo-inositol in anterior cingulate cortex in the METH group relative to CONT. These alterations showed a linear pattern of decreased levels ('normalization') by 1 year of abstinence. We also found decreases in glutamine and Glx (composed mainly of glutamate and glutamine) in the caudate-putamen of the same animals at early withdrawal that showed a similar linear pattern of increasing concentration by 1 year. These results demonstrate that despite protracted, long-term use, neurochemical changes seen following long-term drug administration do not persist following prolonged abstinence, suggesting therapeutic effects of long-term withdrawal from drug use.
JF - Addiction Biology
AU - Yang, Shaolin
AU - Belcher, Annabelle M
AU - Chefer, Svetlana
AU - Vaupel, DBruce
AU - Schindler, Charles W
AU - Stein, Elliot A
AU - Yang, Yihong
AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
Y1 - 2015/01//
PY - 2015
DA - Jan 2015
SP - 69
EP - 79
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 20
IS - 1
SN - 1355-6215, 1355-6215
KW - Toxicology Abstracts; CSA Neurosciences Abstracts
KW - Glutamine
KW - Caudate-putamen
KW - Withdrawal
KW - Brain
KW - Neurochemistry
KW - Drug abuse
KW - Primates
KW - Cortex (cingulate)
KW - Methamphetamine
KW - Magnetic resonance spectroscopy
KW - Self-administration
KW - Macaca mulatta
KW - Addiction
KW - Glutamic acid
KW - X 24380:Social Poisons & Drug Abuse
KW - N3 11001:Behavioral and Cognitive Neuroscience
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647024729?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+Biology&rft.atitle=Withdrawal+from+long-term+methamphetamine+self-administration+%27normalizes%27+neurometabolites+in+rhesus+monkeys%3A+a+super%281%29H+MR+spectroscopy+study&rft.au=Yang%2C+Shaolin%3BBelcher%2C+Annabelle+M%3BChefer%2C+Svetlana%3BVaupel%2C+DBruce%3BSchindler%2C+Charles+W%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Yang&rft.aufirst=Shaolin&rft.date=2015-01-01&rft.volume=20&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Addiction+Biology&rft.issn=13556215&rft_id=info:doi/10.1111%2Fadb.12078
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-01-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Methamphetamine; Glutamine; Caudate-putamen; Magnetic resonance spectroscopy; Withdrawal; Brain; Self-administration; Neurochemistry; Glutamic acid; Addiction; Drug abuse; Cortex (cingulate); Macaca mulatta; Primates
DO - http://dx.doi.org/10.1111/adb.12078
ER -
TY - JOUR
T1 - OdoCapsule: Next-Generation Wireless Capsule Endoscopy With Accurate Lesion Localization and Video Stabilization Capabilities
AN - 1647020562; 21210091
AB - In this paper, we propose a platform to achieve accurate localization of small-bowel lesions and endoscopic video stabilization in wireless capsule endoscopy. Current research modules rely on the use of external magnetic fields and triangulation methods to calculate the position vector of the capsule, leading to considerable error margins. Our platform, entitled OdoCapsule (a synthesis of the words Odometer and Capsule), provides real-time distance information from the point of duodenal entry to the point of exit from the small bowel. To achieve this, OdoCapsule is equipped with three miniature legs. Each leg carries a soft rubber wheel, which is made with human-compliant material. These legs are extendable and retractable thanks to a micromotor and three custom-made torsion springs. The wheels are specifically designed to function as microodometers: each rotation they perform is registered. Hence, the covered distance is measured accurately in real time. Furthermore, with its legs fully extended, OdoCapsule can stabilize itself inside the small-bowel lumen thus offering smoother video capture and better image processing. Recent ex vivo testing of this concept, using porcine small bowel and a commercially available (custom-modified) capsule endoscope, has proved its viability.
JF - IEEE Transactions on Biomedical Engineering
AU - Karargyris, Alexandros
AU - Koulaouzidis, Anastastios
AD - , National Library of Medicine National Institutes of Health, Bethesda, MD, USA
Y1 - 2015/01//
PY - 2015
DA - Jan 2015
SP - 352
EP - 360
PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 United States
VL - 62
IS - 1
SN - 0018-9294, 0018-9294
KW - Biotechnology and Bioengineering Abstracts
KW - Leg
KW - Magnetic fields
KW - Intestine
KW - Rubber
KW - Image processing
KW - Endoscopes
KW - Endoscopy
KW - W 30905:Medical Applications
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647020562?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Biomedical+Engineering&rft.atitle=OdoCapsule%3A+Next-Generation+Wireless+Capsule+Endoscopy+With+Accurate+Lesion+Localization+and+Video+Stabilization+Capabilities&rft.au=Karargyris%2C+Alexandros%3BKoulaouzidis%2C+Anastastios&rft.aulast=Karargyris&rft.aufirst=Alexandros&rft.date=2015-01-01&rft.volume=62&rft.issue=1&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Biomedical+Engineering&rft.issn=00189294&rft_id=info:doi/10.1109%2FTBME.2014.2352493
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-01-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Leg; Magnetic fields; Intestine; Image processing; Rubber; Endoscopes; Endoscopy
DO - http://dx.doi.org/10.1109/TBME.2014.2352493
ER -
TY - JOUR
T1 - Design of self-assembling peptide hydrogelators amenable to bacterial expression
AN - 1647006236; 21286534
AB - Hydrogels formed from self-assembling peptides are finding use in tissue engineering and drug delivery applications. Given the notorious difficulties associated with producing self-assembling peptides by recombinant expression, most are typically prepared by chemical synthesis. Herein, we report the design of a family of self-assembling beta -hairpin peptides amenable to efficient production using an optimized bacterial expression system. Expressing peptides, EX1, EX2 and EX3 contain identical eight-residue amphiphilic beta -strands connected by varying turn sequences that are responsible for ensuring chain reversal and the proper intramolecular folding and consequent self-assembly of the peptide into a hydrogel network under physiological conditions. EX1 was initially used to establish and optimize the bacterial expression system by which all the peptides could be eventually individually expressed. Expression clones were designed to allow exploration of possible fusion partners and investigate both enzymatic and chemical cleavage as means to liberate the target peptide. A systematic analysis of possible expression systems followed by fermentation optimization lead to a system in which all three peptides could be expressed as fusions with BAD-BH3, the BH3 domain of the proapoptotic BAD (Bcl-2 Associated Death) Protein. CNBr cleavage followed by purification afforded 50, 31, and 15 mg/L yields of pure EX1, EX2 and EX3, respectively. CD spectroscopy, TEM, and rheological analysis indicate that these peptides fold and assembled into well-defined fibrils that constitute hydrogels having shear-thin/recovery properties.
JF - Biomaterials
AU - Sonmez, Cem
AU - Nagy, Katelyn J
AU - Schneider, Joel P
AD - National Cancer Institute, Center for Cancer Research, Frederick, MD 21701, United States
Y1 - 2015/01//
PY - 2015
DA - Jan 2015
SP - 62
EP - 72
PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom
VL - 37
SN - 0142-9612, 0142-9612
KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts
KW - Hydrogel
KW - Peptide
KW - Assembly
KW - Expression
KW - Injectable
KW - Bacteria
KW - Drug delivery
KW - Apoptosis
KW - hydrogels
KW - Fermentation
KW - Self-assembly
KW - Bcl-2 protein
KW - Tissue engineering
KW - Spectroscopy
KW - Fibrils
KW - J 02310:Genetics & Taxonomy
KW - W 30920:Tissue Engineering
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647006236?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Design+of+self-assembling+peptide+hydrogelators+amenable+to+bacterial+expression&rft.au=Sonmez%2C+Cem%3BNagy%2C+Katelyn+J%3BSchneider%2C+Joel+P&rft.aulast=Sonmez&rft.aufirst=Cem&rft.date=2015-01-01&rft.volume=37&rft.issue=&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2014.10.011
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-01-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Drug delivery; Apoptosis; hydrogels; Fermentation; Self-assembly; Bcl-2 protein; Spectroscopy; Tissue engineering; Fibrils; Bacteria
DO - http://dx.doi.org/10.1016/j.biomaterials.2014.10.011
ER -
TY - JOUR
T1 - Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential.
AN - 1643406948; 25302578
AB - Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and druglike molecules impact mitochondrial function represents an initial step in predicting exposure-related toxicity and defining a possible role for such compounds in the onset of various diseases.
We sought to identify individual chemicals and general structural features associated with changes in mitochondrial membrane potential (MMP). We used a multiplexed [two end points in one screen; MMP and adenosine triphosphate (ATP) content] quantitative high throughput screening (qHTS) approach combined with informatics tools to screen the Tox21 library of 10,000 compounds (~ 8,300 unique chemicals) at 15 concentrations each in triplicate to identify chemicals and structural features that are associated with changes in MMP in HepG2 cells. Approximately 11% of the compounds (913 unique compounds) decreased MMP after 1 hr of treatment without affecting cell viability (ATP content). In addition, 309 compounds decreased MMP over a concentration range that also produced measurable cytotoxicity [half maximal inhibitory concentration (IC50) in MMP assay/IC50 in viability assay ≤ 3; p < 0.05]. More than 11% of the structural clusters that constitute the Tox21 library (76 of 651 clusters) were significantly enriched for compounds that decreased the MMP. Our multiplexed qHTS approach allowed us to generate a robust and reliable data set to evaluate the ability of thousands of drugs and environmental compounds to decrease MMP. The use of structure-based clustering analysis allowed us to identify molecular features that are likely responsible for the observed activity.
JF - Environmental health perspectives
AU - Attene-Ramos, Matias S
AU - Huang, Ruili
AU - Michael, Sam
AU - Witt, Kristine L
AU - Richard, Ann
AU - Tice, Raymond R
AU - Simeonov, Anton
AU - Austin, Christopher P
AU - Xia, Menghang
AD - National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 49
EP - 56
VL - 123
IS - 1
KW - Environmental Pollutants
KW - 0
KW - Adenosine Triphosphate
KW - 8L70Q75FXE
KW - Index Medicus
KW - Hep G2 Cells
KW - Dose-Response Relationship, Drug
KW - Humans
KW - Toxicity Tests
KW - Adenosine Triphosphate -- analysis
KW - Cell Survival
KW - High-Throughput Screening Assays
KW - Membrane Potential, Mitochondrial -- drug effects
KW - Environmental Pollutants -- toxicity
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1643406948?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Profiling+of+the+Tox21+chemical+collection+for+mitochondrial+function+to+identify+compounds+that+acutely+decrease+mitochondrial+membrane+potential.&rft.au=Attene-Ramos%2C+Matias+S%3BHuang%2C+Ruili%3BMichael%2C+Sam%3BWitt%2C+Kristine+L%3BRichard%2C+Ann%3BTice%2C+Raymond+R%3BSimeonov%2C+Anton%3BAustin%2C+Christopher+P%3BXia%2C+Menghang&rft.aulast=Attene-Ramos&rft.aufirst=Matias&rft.date=2015-01-01&rft.volume=123&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408642
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-22
N1 - Date created - 2015-01-07
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7 [19076321]
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Comment In:
Environ Health Perspect. 2015 Jan;123(1):A23 [25561610]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1289/ehp.1408642
ER -
TY - JOUR
T1 - Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells.
AN - 1643406894; 25136773
AB - The link between environmental estrogen exposure and defects in the female reproductive tract is well established. The phytoestrogen genistein is able to modulate uterine estrogen receptor (ER) activity, and dietary exposure is associated with uterine pathologies. Regulation of stress and immune functions by the glucocorticoid receptor (GR) is also an integral part of maintaining reproductive tract function; disruption of GR signaling by genistein may also have a role in the adverse effects of genistein.
We evaluated the transcriptional response to genistein in Ishikawa cells and investigated the effects of genistein on GR-mediated target genes. We used Ishikawa cells as a model system to identify novel targets of genistein and the synthetic glucocorticoid dexamethasone through whole genome microarray analysis. Common gene targets were defined and response patterns verified by quantitative real-time reverse-transcription polymerase chain reaction. The mechanism of transcriptional antagonism was determined for select genes.
Genistein regulated numerous genes in Ishikawa cells independently of estradiol, and the response to coadministration of genistein and dexamethasone was unique compared with the response to either estradiol or dexamethasone alone. Furthermore, genistein altered glucocorticoid regulation of GR target genes. In a select set of genes, co-regulation by dexamethasone and genistein was found to require both GR and ERα signaling, respectively. Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome.
JF - Environmental health perspectives
AU - Whirledge, Shannon
AU - Senbanjo, Linda T
AU - Cidlowski, John A
AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 80
EP - 87
VL - 123
IS - 1
KW - Estrogen Receptor alpha
KW - 0
KW - Phytoestrogens
KW - Receptors, Glucocorticoid
KW - estrogen receptor alpha, human
KW - Estradiol
KW - 4TI98Z838E
KW - Dexamethasone
KW - 7S5I7G3JQL
KW - Genistein
KW - DH2M523P0H
KW - Index Medicus
KW - Real-Time Polymerase Chain Reaction
KW - Humans
KW - Signal Transduction -- drug effects
KW - Estradiol -- pharmacology
KW - Microarray Analysis
KW - Estrogen Receptor alpha -- drug effects
KW - Cell Line, Tumor
KW - Uterus -- drug effects
KW - Female
KW - Gene Expression -- drug effects
KW - Receptors, Glucocorticoid -- drug effects
KW - Genistein -- pharmacology
KW - Phytoestrogens -- pharmacology
KW - Gene Expression Regulation -- drug effects
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-22
N1 - Date created - 2015-01-07
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Mol Hum Reprod. 2000 Jan;6(1):68-74 [10611263]
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Epidemiol Rev. 1990;12:1-15 [2286214]
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Hum Reprod Update. 2008 Jan-Feb;14(1):59-72 [18070835]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1289/ehp.1408437
ER -
TY - JOUR
T1 - Perfluorochemicals and human semen quality: the LIFE study.
AN - 1643406797; 25127343
AB - The relation between persistent environmental chemicals and semen quality is evolving, although limited data exist for men recruited from general populations.
We examined the relation between perfluorinated chemicals (PFCs) and semen quality among 501 male partners of couples planning pregnancy. Using population-based sampling strategies, we recruited 501 couples discontinuing contraception from two U.S. geographic regions from 2005 through 2009. Baseline interviews and anthropometric assessments were conducted, followed by blood collection for the quantification of seven serum PFCs (perfluorosulfonates, perfluorocarboxylates, and perfluorosulfonamides) using tandem mass spectrometry. Men collected a baseline semen sample and another approximately 1 month later. Semen samples were shipped with freezer packs, and analyses were performed on the day after collection. We used linear regression to estimate the difference in each semen parameter associated with a one unit increase in the natural log-transformed PFC concentration after adjusting for confounders and modeling repeated semen samples. Sensitivity analyses included optimal Box-Cox transformation of semen quality end points.
Six PFCs [2-(N-methyl-perfluorooctane sulfonamido) acetate (Me-PFOSA-AcOH), perfluorodecanoate (PFDeA), perfluorononanoate (PFNA), perfluorooctane sulfonamide (PFOSA), perfluorooctane sulfonate (PFOS), and perfluorooctanoic acid (PFOA)] were associated with 17 semen quality end points before Box-Cox transformation. PFOSA was associated with smaller sperm head area and perimeter, a lower percentage of DNA stainability, and a higher percentage of bicephalic and immature sperm. PFDeA, PFNA, PFOA, and PFOS were associated with a lower percentage of sperm with coiled tails.
Select PFCs were associated with certain semen end points, with the most significant associations observed for PFOSA but with results in varying directions.
JF - Environmental health perspectives
AU - Louis, Germaine M Buck
AU - Chen, Zhen
AU - Schisterman, Enrique F
AU - Kim, Sungduk
AU - Sweeney, Anne M
AU - Sundaram, Rajeshwari
AU - Lynch, Courtney D
AU - Gore-Langton, Robert E
AU - Barr, Dana Boyd
AD - Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 57
EP - 63
VL - 123
IS - 1
KW - Environmental Pollutants
KW - 0
KW - Fluorocarbons
KW - Index Medicus
KW - Humans
KW - Linear Models
KW - Adult
KW - Environmental Exposure
KW - Texas
KW - Tandem Mass Spectrometry
KW - Michigan
KW - Male
KW - Environmental Pollutants -- toxicity
KW - Semen Analysis
KW - Fluorocarbons -- toxicity
KW - Semen -- drug effects
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Perfluorochemicals+and+human+semen+quality%3A+the+LIFE+study.&rft.au=Louis%2C+Germaine+M+Buck%3BChen%2C+Zhen%3BSchisterman%2C+Enrique+F%3BKim%2C+Sungduk%3BSweeney%2C+Anne+M%3BSundaram%2C+Rajeshwari%3BLynch%2C+Courtney+D%3BGore-Langton%2C+Robert+E%3BBarr%2C+Dana+Boyd&rft.aulast=Louis&rft.aufirst=Germaine+M&rft.date=2015-01-01&rft.volume=123&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1307621
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-22
N1 - Date created - 2015-01-07
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Fertil Steril. 2000 Jan;73(1):43-50 [10632410]
Paediatr Perinat Epidemiol. 2011 Sep;25(5):413-24 [21819423]
Fertil Steril. 2001 Nov;76(5):879-83 [11704105]
J Androl. 2002 Jan-Feb;23(1):25-43 [11780920]
Best Pract Res Clin Endocrinol Metab. 2002 Jun;16(2):289-309 [12064894]
J Androl. 2002 Sep-Oct;23(5):629-34 [12185096]
Am J Epidemiol. 2003 Feb 15;157(4):355-63 [12578806]
Environ Sci Technol. 2011 Oct 1;45(19):8037-45 [21469664]
Toxicol Appl Pharmacol. 2012 Jan 15;258(2):248-55 [22119708]
Reprod Toxicol. 2012 Jul;33(4):419-27 [21736937]
Reprod Toxicol. 2012 Jul;33(4):577-83 [22449571]
Hum Reprod. 2012 Aug;27(8):2532-40 [22647447]
Methods Mol Biol. 2013;927:27-37 [22992901]
Methods Mol Biol. 2013;927:147-64 [22992911]
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Fertil Steril. 2013 Mar 1;99(3):673-7 [23391408]
Urology. 2013 Dec;82(6):1296-9 [24094663]
Chem Res Toxicol. 2003 Jun;16(6):775-81 [12807361]
Environ Health Perspect. 2004 Jan;112(1):79-86 [14698935]
Fertil Steril. 2004 Aug;82(2):358-66 [15302284]
Crit Rev Toxicol. 2004 Jul-Aug;34(4):351-84 [15328768]
J Androl. 1990 Jan-Feb;11(1):32-9 [2312397]
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J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):188-220 [18368553]
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J Urol. 2011 Feb;185(2):381-2 [21168161]
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Syst Biol Reprod Med. 2011 Jun;57(3):133-8 [21299480]
J Androl. 2000 May-Jun;21(3):478-84 [10819457]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1289/ehp.1307621
ER -
TY - JOUR
T1 - Preconception maternal and paternal exposure to persistent organic pollutants and birth size: the LIFE study.
AN - 1643405640; 25095280
AB - Persistent organic pollutants (POPs) are developmental toxicants, but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored.
We examined associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutants, with birth size measures. Parental serum concentrations of 9 organochlorine pesticides, 1 polybrominated biphenyl (PBB), 7 perfluoroalkyl chemicals (PFCs), 10 polybrominated diphenyl ethers (PBDEs), and 36 polychlorinated biphenyls (PCBs) were measured before conception for 234 couples. Differences in birth weight, length, head circumference, and ponderal index were estimated using multiple linear regression per 1-SD increase in natural log-transformed (ln-transformed) chemicals. Models were estimated separately for each parent and adjusted for maternal age, maternal prepregnancy body mass index (kilograms per meter squared) and other confounders, and all models included an interaction term between infant sex and each chemical.
Among girls (n = 117), birth weight was significantly lower (range, 84-195 g) in association with a 1-SD increase in ln-transformed maternal serum concentrations of DDT, PBDE congeners 28 and 183, and paternal serum concentrations of PBDE-183 and PCB-167. Among boys (n = 113), maternal (PCBs 138, 153, 167, 170, 195, and 209 and perfluorooctane sulfonamide) and paternal (PCBs 172 and 195) serum concentrations of several POPs were statistically associated with lower birth weight (range, 98-170 g), whereas paternal concentrations of PBDEs (66, 99) were associated with higher birth weight. Differences in offspring head circumference, length, and ponderal index were also associated with parental exposures. Preconceptional maternal and paternal concentrations of several POPs were associated with statistically significant differences in birth size among offspring.
JF - Environmental health perspectives
AU - Robledo, Candace A
AU - Yeung, Edwina
AU - Mendola, Pauline
AU - Sundaram, Rajeshwari
AU - Maisog, Jose
AU - Sweeney, Anne M
AU - Barr, Dana Boyd
AU - Louis, Germaine M Buck
AD - Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 88
EP - 94
VL - 123
IS - 1
KW - Environmental Pollutants
KW - 0
KW - Hydrocarbons, Halogenated
KW - Pesticides
KW - Index Medicus
KW - Hydrocarbons, Halogenated -- toxicity
KW - Humans
KW - Infant, Newborn
KW - Texas
KW - Hydrocarbons, Halogenated -- blood
KW - Pregnancy
KW - Pesticides -- toxicity
KW - Body Size -- drug effects
KW - Prenatal Exposure Delayed Effects -- chemically induced
KW - Adult
KW - Cohort Studies
KW - Middle Aged
KW - Michigan
KW - Adolescent
KW - Environmental Exposure -- adverse effects
KW - Female
KW - Male
KW - Pesticides -- blood
KW - Maternal Exposure -- adverse effects
KW - Environmental Pollutants -- toxicity
KW - Paternal Exposure -- adverse effects
KW - Maternal Exposure -- statistics & numerical data
KW - Birth Weight -- drug effects
KW - Paternal Exposure -- statistics & numerical data
KW - Environmental Pollutants -- blood
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Preconception+maternal+and+paternal+exposure+to+persistent+organic+pollutants+and+birth+size%3A+the+LIFE+study.&rft.au=Robledo%2C+Candace+A%3BYeung%2C+Edwina%3BMendola%2C+Pauline%3BSundaram%2C+Rajeshwari%3BMaisog%2C+Jose%3BSweeney%2C+Anne+M%3BBarr%2C+Dana+Boyd%3BLouis%2C+Germaine+M+Buck&rft.aulast=Robledo&rft.aufirst=Candace&rft.date=2015-01-01&rft.volume=123&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1308016
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-22
N1 - Date created - 2015-01-07
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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Curr Opin Pediatr. 2010 Apr;22(2):208-18 [20216314]
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Sci Total Environ. 2010 Nov 1;408(23):5758-67 [20832846]
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Pediatrics. 2011 Apr;127(4):734-41 [21382949]
Paediatr Perinat Epidemiol. 2011 Sep;25(5):413-24 [21819423]
Chemosphere. 2011 Sep;84(10):1301-9 [21663933]
Am J Epidemiol. 2011 Oct 15;174(8):885-92 [21878423]
J Expo Sci Environ Epidemiol. 2012 Jan-Feb;22(1):60-9 [21971379]
Environ Int. 2012 Apr;40:162-9 [21820740]
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Environ Health. 2012;11:49 [22817616]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1289/ehp.1308016
ER -
TY - JOUR
T1 - Insecticide residues in soil, water, and eggplant fruits and farmers' health effects due to exposure to pesticides.
AN - 1643146328; 25413584
AB - Eggplant (Solanum melongena L.) is an important vegetable crop that is widely cultivated in the tropical and subtropical areas in Asia. Globally, the top three eggplant producers are China, India, and Egypt. The Philippines has been one of the top 10 eggplant-producing countries based on area planted and crop productivity. This study aims to describe the insecticide residues found in soil, water, and eggplant fruits in eggplant farms in Sta. Maria, Pangasinan.
The study design is a cross sectional of randomly selected eggplant farms in Sta. Maria, Pangasinan. Soil, water, and eggplant fruits were collected and subjected to gas chromatography (Shimadzu) analysis for multi-pesticide residues. Farmers from Sta. Maria, Pangasinan were found to be applying a broad spectrum of insecticides on their eggplant crop. Soil samples from 11 (about 42%) out of the 26 farms tested positive for insecticide residues, six of which from four farms exceeded the acceptable maximum residue limit. These residues were profenofos, triazophos, chlorpyrifos, cypermethrin, and malathion. No insecticide residues were detected from water samples taken from the 26 farms. Cypermethrin and chlorpyrifos were the insecticide residues detected in eggplant fruit samples. A maximum of 20% of the eggplant samples tested positive for insecticide residues. In the eggplant fruit study, all farmers have been using Prevathon(®) for 24 years at a rate of 10 ml/application, and Malathion(®) for 25 years at about 16.5 ml/application, respectively equivalent to 0.24 liter-years and 0.413 liter-years of exposure. Similarly, to the findings in the soil and water study, although Brodan(®) and Magnum(®) were not prevalently applied, the farmers' liter-years of exposure to these insecticides, and their active ingredients, were highest at about 18.92 and 10.0, respectively. The farmers and farm workers in the soil and water study reported experiencing itchiness of the skin (63.8%), redness of the eyes (29.3%), muscle pains (27.6%), and headaches (27.6%), as being related to their pesticide exposure. In summary, a maximum of 20% of the eggplant samples tested positive for insecticide residues at any one stage of sampling done. The farmers and farm workers also reported of pesticide-related illnesses but none of them sought any medical attention. Intervention to reduce the farmers' pesticide exposure can focus on the risk factors identified, primarily the toxicity of pesticides used, the unsafe application practices, and the adverse health effects of pesticide exposure.
JF - Environmental health and preventive medicine
AU - Del Prado-Lu, Jinky Leilanie
AD - Institute of Health Policy and Development Studies, National Institutes of Health, University of the Philippines Manila, NIH Bldg, P. Gil St., UP Manila, Taft Avenue, 1100, Manila, Philippines, jinky_lu@yahoo.com.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 53
EP - 62
VL - 20
IS - 1
KW - Insecticides
KW - 0
KW - Pesticide Residues
KW - Pesticides
KW - Soil Pollutants
KW - Water Pollutants, Chemical
KW - Index Medicus
KW - Cross-Sectional Studies
KW - Water Pollutants, Chemical -- analysis
KW - Humans
KW - Food Contamination -- analysis
KW - Interviews as Topic
KW - Pesticide Residues -- analysis
KW - Philippines -- epidemiology
KW - Pesticides -- adverse effects
KW - Soil Pollutants -- analysis
KW - Insecticides -- adverse effects
KW - Insecticides -- administration & dosage
KW - Agricultural Workers' Diseases -- epidemiology
KW - Agricultural Workers' Diseases -- chemically induced
KW - Occupational Exposure -- adverse effects
KW - Solanum melongena -- chemistry
KW - Insecticides -- analysis
KW - Occupational Exposure -- analysis
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1643146328?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+and+preventive+medicine&rft.atitle=Insecticide+residues+in+soil%2C+water%2C+and+eggplant+fruits+and+farmers%27+health+effects+due+to+exposure+to+pesticides.&rft.au=Del+Prado-Lu%2C+Jinky+Leilanie&rft.aulast=Del+Prado-Lu&rft.aufirst=Jinky&rft.date=2015-01-01&rft.volume=20&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Environmental+health+and+preventive+medicine&rft.issn=1347-4715&rft_id=info:doi/10.1007%2Fs12199-014-0425-3
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-08-27
N1 - Date created - 2015-01-06
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1007/s12199-014-0425-3
ER -
TY - JOUR
T1 - Integrative genomic and transcriptomic characterization of matched primary and metastatic liver and colorectal carcinoma.
AN - 1641858269; 25552933
AB - Metastasis is the main cause of cancer mortality but its process remains poorly understood and thus hampers more effective treatment and improved cancer prognosis. To search for metastasis driver genes responsible for tumor spread, we integrated genomic and transcriptomic profiles of 61 matched primary tumors and distant metastases of liver or colorectal carcinoma isolated by laser-capture microdissection and assayed by array-based technologies. We found that primary tumor lesions and their matched distant metastases were largely similar at the genomic and transcriptomic levels, but substantial differences could be found between primary tumors with or without accompanying metastases. Interestingly, metastasis genes were principally tumor type and organ site-specific. Despite distinct pathway enrichment, different metastasis gene sets shared common prognostic capacity and were predictive of hepatocellular carcinoma survival in an independent cohort. Thus, the metastatic propensity is inherent to the primary tumor and the lack of general metastasis genes necessitates the development of specific treatment modalities.
JF - International journal of biological sciences
AU - Roessler, Stephanie
AU - Lin, Guoling
AU - Forgues, Marshonna
AU - Budhu, Anuradha
AU - Hoover, Shelley
AU - Simpson, R Mark
AU - Wu, Xiaolin
AU - He, Ping
AU - Qin, Lun-Xiu
AU - Tang, Zhao-You
AU - Ye, Qing-Hai
AU - Wang, Xin Wei
AD - 1. Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA; ; 1. Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA; ; 2. Liver Cancer Institute, Fudan University, Shanghai, China; ; 3. Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA; ; 4. Laboratory of Molecular Technology, NCI-Frederick, SAIC-Frederick, Frederick, MD 21701, USA; ; 5. Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. ; 2. Liver Cancer Institute, Fudan University, Shanghai, China;
Y1 - 2015
PY - 2015
DA - 2015
SP - 88
EP - 98
VL - 11
IS - 1
KW - Index Medicus
KW - Organ site-specific metastasis
KW - Liver cancer
KW - Colon cancer
KW - Profiling.
KW - Gene Expression Profiling
KW - Comparative Genomic Hybridization
KW - Humans
KW - Microarray Analysis
KW - Laser Capture Microdissection
KW - China
KW - Colorectal Neoplasms -- secondary
KW - Neoplasm Metastasis -- genetics
KW - Neoplasm Metastasis -- physiopathology
KW - Colorectal Neoplasms -- genetics
KW - Liver Neoplasms -- secondary
KW - Liver Neoplasms -- genetics
KW - Gene Expression Regulation, Neoplastic -- genetics
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+biological+sciences&rft.atitle=Integrative+genomic+and+transcriptomic+characterization+of+matched+primary+and+metastatic+liver+and+colorectal+carcinoma.&rft.au=Roessler%2C+Stephanie%3BLin%2C+Guoling%3BForgues%2C+Marshonna%3BBudhu%2C+Anuradha%3BHoover%2C+Shelley%3BSimpson%2C+R+Mark%3BWu%2C+Xiaolin%3BHe%2C+Ping%3BQin%2C+Lun-Xiu%3BTang%2C+Zhao-You%3BYe%2C+Qing-Hai%3BWang%2C+Xin+Wei&rft.aulast=Roessler&rft.aufirst=Stephanie&rft.date=2015-01-01&rft.volume=11&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=International+journal+of+biological+sciences&rft.issn=1449-2288&rft_id=info:doi/10.7150%2Fijbs.10583
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-14
N1 - Date created - 2015-01-01
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Nat Med. 2006 Aug;12(8):895-904 [16892035]
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Bioinformatics. 2007 Mar 15;23(6):657-63 [17234643]
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Cancer Res. 2009 May 1;69(9):4059-66 [19366792]
Nature. 2010 Feb 18;463(7283):899-905 [20164920]
BMC Surg. 2010;10:27 [20875094]
Cancer Res. 2010 Dec 15;70(24):10202-12 [21159642]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.7150/ijbs.10583
ER -
TY - JOUR
T1 - Free radical generation from an aniline derivative in HepG2 cells: a possible captodative effect.
AN - 1641016976; 25450331
AB - Xenobiotic metabolism can induce the generation of protein radicals, which are believed to play an important role in the toxicity of chemicals and drugs. It is therefore important to identify chemical structures capable of inducing macromolecular free radical formation in living cells. In this study, we evaluated the ability of four structurally related environmental chemicals, aniline, nitrosobenzene, N,N-dimethylaniline, and N,N-dimethyl-4-nitrosoaniline (DMNA), to induce free radicals and cellular damage in the hepatoma cell line HepG2. Cytotoxicity was assessed using lactate dehydrogenase assays, and morphological changes were observed using phase contrast microscopy. Protein free radicals were detected by immuno-spin trapping using in-cell western experiments and confocal microscopy to determine the subcellular locale of free radical generation. DMNA induced free radical generation, lactate dehydrogenase release, and morphological changes in HepG2 cells, whereas aniline, nitrosobenzene, N,N-dimethylaniline did not. Confocal microscopy showed that DMNA induced free radical generation mainly in the cytosol. Preincubation of HepG2 cells with N-acetylcysteine and 2,2'-dipyridyl significantly prevented free radical generation on subsequent incubation with DMNA, whereas preincubation with apocynin and dimethyl sulfoxide had no effect. These results suggest that DMNA is metabolized to reactive free radicals capable of generating protein radicals which may play a critical role in DMNA toxicity. We propose that the captodative effect, the combined action of the electron-releasing dimethylamine substituent, and the electron-withdrawing nitroso substituent, leads to a thermodynamically stabilized radical, facilitating enhanced protein radical formation by DMNA.
Copyright © 2014 Elsevier Inc. All rights reserved.
JF - Free radical biology & medicine
AU - Horinouchi, Yuya
AU - Summers, Fiona A
AU - Ehrenshaft, Marilyn
AU - Mason, Ronald P
AD - Free Radical Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: yuya.h@basic.med.tokushima-u.ac.jp. ; Free Radical Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: summersfa@niehs.nih.gov. ; Free Radical Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: ehrensh1@niehs.nih.gov. ; Free Radical Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: mason4@niehs.nih.gov.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 111
EP - 117
VL - 78
KW - Aniline Compounds
KW - 0
KW - Carcinogens
KW - Free Radical Scavengers
KW - Free Radicals
KW - Nitroso Compounds
KW - 4-nitrosodimethylaniline
KW - 138-89-6
KW - N,N-dimethylaniline
KW - 7426719369
KW - L-Lactate Dehydrogenase
KW - EC 1.1.1.27
KW - aniline
KW - SIR7XX2F1K
KW - nitrosobenzene
KW - ZI9W9E8G2Z
KW - Index Medicus
KW - Cytotoxicity
KW - Immuno-spin trapping
KW - Confocal microscopy
KW - In-cell western
KW - Environmental chemicals
KW - Captodative effect
KW - Microscopy, Confocal
KW - Carcinogens -- pharmacology
KW - Blotting, Western
KW - Spin Trapping
KW - Hep G2 Cells
KW - Humans
KW - Electron Spin Resonance Spectroscopy
KW - L-Lactate Dehydrogenase -- metabolism
KW - Cell Proliferation -- drug effects
KW - Aniline Compounds -- pharmacology
KW - Nitroso Compounds -- pharmacology
KW - Free Radicals -- metabolism
KW - Free Radical Scavengers -- pharmacology
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-10-02
N1 - Date created - 2014-12-29
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.577
ER -
TY - JOUR
T1 - Antiviral activity of a single-domain antibody immunotoxin binding to glycoprotein D of herpes simplex virus 2.
AN - 1640482632; 25385102
AB - Despite years of research dedicated to preventing the sexual transmission of herpes simplex virus 2 (HSV-2), there is still no protective vaccine or microbicide against one of the most common sexually transmitted infections in the world. Using a phage display library constructed from a llama immunized with recombinant HSV-2 glycoprotein D, we identified a single-domain antibody VHH, R33, which binds to the viral surface glycoprotein D. Although R33 does not demonstrate any HSV-2 neutralization activity in vitro, when expressed with the cytotoxic domain of exotoxin A, the resulting immunotoxin (R33ExoA) specifically and potently kills HSV-2-infected cells, with a 50% neutralizing dilution (IC50) of 6.7 nM. We propose that R33ExoA could be used clinically to prevent transmission of HSV-2 through killing of virus-producing epithelial cells during virus reactivation. R33 could also potentially be used to deliver other cytotoxic effectors to HSV-2-infected cells. Copyright © 2015, American Society for Microbiology. All Rights Reserved.
JF - Antimicrobial agents and chemotherapy
AU - Geoghegan, Eileen M
AU - Zhang, Hong
AU - Desai, Prashant J
AU - Biragyn, Arya
AU - Markham, Richard B
AD - The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. ; Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland, USA. ; Immunoregulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, Maryland, USA. ; The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA rmarkha1@jhu.edu.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 527
EP - 535
VL - 59
IS - 1
KW - Antiviral Agents
KW - 0
KW - Bacterial Toxins
KW - Exotoxins
KW - Immunotoxins
KW - Recombinant Fusion Proteins
KW - Single-Domain Antibodies
KW - Viral Envelope Proteins
KW - Virulence Factors
KW - glycoprotein D-herpes simplex virus type 2
KW - ADP Ribose Transferases
KW - EC 2.4.2.-
KW - toxA protein, Pseudomonas aeruginosa
KW - EC 2.4.2.31
KW - Index Medicus
KW - Animals
KW - Exotoxins -- genetics
KW - ADP Ribose Transferases -- immunology
KW - Recombinant Fusion Proteins -- immunology
KW - Vero Cells -- drug effects
KW - Vero Cells -- virology
KW - Virulence Factors -- genetics
KW - Bacterial Toxins -- immunology
KW - Exotoxins -- immunology
KW - Virulence Factors -- immunology
KW - ADP Ribose Transferases -- genetics
KW - Bacterial Toxins -- genetics
KW - Immunotoxins -- immunology
KW - Cercopithecus aethiops
KW - Recombinant Fusion Proteins -- genetics
KW - Neutralization Tests
KW - Toxicity Tests -- methods
KW - Recombinant Fusion Proteins -- pharmacology
KW - Camelids, New World
KW - Immunotoxins -- genetics
KW - Immunotoxins -- pharmacology
KW - Herpesvirus 2, Human -- drug effects
KW - Single-Domain Antibodies -- genetics
KW - Antiviral Agents -- pharmacology
KW - Single-Domain Antibodies -- immunology
KW - Single-Domain Antibodies -- pharmacology
KW - Viral Envelope Proteins -- metabolism
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Antiviral+activity+of+a+single-domain+antibody+immunotoxin+binding+to+glycoprotein+D+of+herpes+simplex+virus+2.&rft.au=Geoghegan%2C+Eileen+M%3BZhang%2C+Hong%3BDesai%2C+Prashant+J%3BBiragyn%2C+Arya%3BMarkham%2C+Richard+B&rft.aulast=Geoghegan&rft.aufirst=Eileen&rft.date=2015-01-01&rft.volume=59&rft.issue=1&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=1098-6596&rft_id=info:doi/10.1128%2FAAC.03818-14
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2016-02-22
N1 - Date created - 2014-12-24
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1128/AAC.03818-14
ER -
TY - JOUR
T1 - Sirolimus use and cancer incidence among US kidney transplant recipients.
AN - 1640330521; 25522018
AB - Sirolimus has anti-carcinogenic properties and can be included in maintenance immunosuppressive therapy following kidney transplantation. We investigated sirolimus effects on cancer incidence among kidney recipients. The US transplant registry was linked with 15 population-based cancer registries and national pharmacy claims. Recipients contributed sirolimus-exposed time when sirolimus claims were filled, and unexposed time when other immunosuppressant claims were filled without sirolimus. Cox regression was used to estimate associations with overall and specific cancer incidence, excluding nonmelanoma skin cancers (not captured in cancer registries). We included 32,604 kidney transplants (5687 sirolimus-exposed). Overall, cancer incidence was suggestively lower during sirolimus use (hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.70-1.11). Prostate cancer incidence was higher during sirolimus use (HR = 1.86, 95% CI = 1.15-3.02). Incidence of other cancers was similar or lower with sirolimus use, with a 26% decrease overall (HR = 0.74, 95% CI = 0.57-0.96, excluding prostate cancer). Results were similar after adjustment for demographic and clinical characteristics. This modest association does not provide strong evidence that sirolimus prevents posttransplant cancer, but it may be advantageous among kidney recipients with high cancer risk. Increased prostate cancer diagnoses may result from sirolimus effects on screen detection. © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.
JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
AU - Yanik, E L
AU - Gustafson, S K
AU - Kasiske, B L
AU - Israni, A K
AU - Snyder, J J
AU - Hess, G P
AU - Engels, E A
AU - Segev, D L
AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 129
EP - 136
VL - 15
IS - 1
KW - Immunosuppressive Agents
KW - 0
KW - Sirolimus
KW - W36ZG6FT64
KW - Index Medicus
KW - immunosuppressant
KW - immunosuppression/immune modulation
KW - health services and outcomes research
KW - mechanistic target of rapamycin: sirolimus
KW - epidemiology
KW - clinical research/practice
KW - Cancer/malignancy/neoplasia
KW - hematology/oncology
KW - kidney transplantation/nephrology
KW - Kidney Function Tests
KW - Humans
KW - Prognosis
KW - Risk Assessment
KW - Registries
KW - Glomerular Filtration Rate
KW - Adult
KW - Graft Rejection -- drug therapy
KW - Incidence
KW - Follow-Up Studies
KW - Middle Aged
KW - United States -- epidemiology
KW - Female
KW - Male
KW - Kidney Transplantation
KW - Neoplasms -- epidemiology
KW - Kidney Failure, Chronic -- surgery
KW - Sirolimus -- therapeutic use
KW - Immunosuppressive Agents -- therapeutic use
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+transplantation+%3A+official+journal+of+the+American+Society+of+Transplantation+and+the+American+Society+of+Transplant+Surgeons&rft.atitle=Sirolimus+use+and+cancer+incidence+among+US+kidney+transplant+recipients.&rft.au=Dunleavy%2C+Kieron&rft.aulast=Dunleavy&rft.aufirst=Kieron&rft.date=2014-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2014%29&rft.issn=&rft_id=info:doi/
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-25
N1 - Date created - 2014-12-23
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1111/ajt.12969
ER -
TY - JOUR
T1 - Class act: safety comparison of approved tyrosine kinase inhibitors for non-small-cell lung carcinoma.
AN - 1637568396; 25345687
AB - The past decade has seen the development and widespread use of tyrosine kinase inhibitors (TKIs) targeting a mutated EGFR (mEGFR) for the treatment of metastatic NSCLC. We discuss the main properties of the TKIs currently recommended for the treatment of mEGFR NSCLC: gefitinib, erlotinib and afatinib. The mechanism of action, pharmacodynamics and pharmacokinetics of these drugs, with emphasis on the historical context of their preclinical and clinical development, will be covered, including potential resistance mechanisms to these first-generation TKIs that has driven the trial design for second and third generations of EGFR inhibitors. Six Phase III clinical trials comparing these three TKIs with cisplatin-based chemotherapy upfront for mEGFR NSCLC provide the basis for the comparative safety and toxicity analysis between these agents. Class-related toxicity of these EGFR inhibitors, including life-threatening effects, will be discussed.
Toxicity and safety analysis from the Phase III trials of these agents in mEGFR populations suggests that afatinib has more frequent and severe side effects. Given that an efficacy advantage has not yet been demonstrated for afatinib over erlotinib and gefitinib, the consistent class toxicity profile of these agents means that gefitinib and erlotinib are a safer first-line treatment recommendation.
JF - Expert opinion on drug safety
AU - Burotto, Mauricio
AU - Ali, Syed Abbas
AU - O'Sullivan Coyne, Geraldine
AD - National Cancer Institute, National Institutes of Health National, Center for Cancer Research , Maryland, USA10 Center Dr, 12N226, Bethesda, MD 20892 , USA +1 301 496 4916 ; +1 301 402 0172 ; mauricio.burottopichun@nih.gov.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 97
EP - 110
VL - 14
IS - 1
KW - Antineoplastic Agents
KW - 0
KW - Protein Kinase Inhibitors
KW - Quinazolines
KW - afatinib
KW - 41UD74L59M
KW - Erlotinib Hydrochloride
KW - DA87705X9K
KW - Protein-Tyrosine Kinases
KW - EC 2.7.10.1
KW - Receptor, Epidermal Growth Factor
KW - gefitinib
KW - S65743JHBS
KW - Index Medicus
KW - tyrosine kinase inhibitor
KW - safety
KW - toxicity
KW - mutated EGFR
KW - clinical trial
KW - erlotinib
KW - Protein Kinase Inhibitors -- therapeutic use
KW - Protein Kinase Inhibitors -- adverse effects
KW - Humans
KW - Antineoplastic Agents -- pharmacokinetics
KW - Protein Kinase Inhibitors -- pharmacokinetics
KW - Antineoplastic Agents -- therapeutic use
KW - Mutation
KW - Models, Biological
KW - Antineoplastic Agents -- adverse effects
KW - Quinazolines -- pharmacokinetics
KW - Protein-Tyrosine Kinases -- antagonists & inhibitors
KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors
KW - Receptor, Epidermal Growth Factor -- genetics
KW - Lung Neoplasms -- drug therapy
KW - Quinazolines -- adverse effects
KW - Carcinoma, Non-Small-Cell Lung -- drug therapy
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1637568396?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+safety&rft.atitle=Class+act%3A+safety+comparison+of+approved+tyrosine+kinase+inhibitors+for+non-small-cell+lung+carcinoma.&rft.au=Burotto%2C+Mauricio%3BAli%2C+Syed+Abbas%3BO%27Sullivan+Coyne%2C+Geraldine&rft.aulast=Burotto&rft.aufirst=Mauricio&rft.date=2015-01-01&rft.volume=14&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+safety&rft.issn=1744-764X&rft_id=info:doi/10.1517%2F14740338.2014.973400
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-14
N1 - Date created - 2014-12-16
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1517/14740338.2014.973400
ER -
TY - JOUR
T1 - Acute air pollution exposure and blood pressure at delivery among women with and without hypertension.
AN - 1637558422; 24795401
AB - Chronic air pollution exposure increases risk for hypertensive disorders of pregnancy, but the effect of acute air pollution exposure on blood pressure during pregnancy is less well known.
We studied 151,276 singleton term deliveries from the Consortium on Safe Labor (2002-2008) with clinical blood pressure measured at admission to labor/delivery and diagnoses of hypertensive disorders collected from electronic medical records and hospital discharge summaries. Air pollution exposures were estimated for the admission hour and the 4 hours preceding admission using a modified version of the Community Multiscale Air Quality models and observed air monitoring data. Blood pressure was categorized as normal; high normal; and mild, moderate, or severe hypertension based on pregnancy cut points. Adjusted ordinal logistic regression estimated the odds of women having a higher admission blood pressure category as a function of air pollutant, hypertensive disorders, and their interaction effect. Odds of high blood pressure at admission to labor/delivery were increased in normotensive women after exposure to nitrogen oxides (by 0.2%/5 units), sulfur dioxide (by 0.3%/1 unit), carbon monoxide and several air toxics (by 3%-4%/high exposure). The effects were often similar or stronger among women with gestational hypertension and preeclampsia. Exposure to particulate matter <10 μm increased odds of high blood pressure in women with preeclampsia by 3%/5 units.
Air pollution can influence admission blood pressure in term deliveries and may increase likelihood of preeclampsia screening at delivery admission. © Published by Oxford University Press on behalf of American Journal of Hypertension Ltd 2014. This work is written by (a) US Government employees(s) and is in the public domain in the US.
JF - American journal of hypertension
AU - Männistö, Tuija
AU - Mendola, Pauline
AU - Liu, Danping
AU - Leishear, Kira
AU - Sherman, Seth
AU - Laughon, S Katherine
AD - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland; ; Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland; pauline.mendola@nih.gov. ; Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland; ; Glotech, Rockville, Maryland; ; The EMMES Corporation, Rockville, Maryland.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 58
EP - 72
VL - 28
IS - 1
KW - Air Pollutants
KW - 0
KW - Particulate Matter
KW - Index Medicus
KW - pregnancy.
KW - blood pressure
KW - hypertension
KW - epidemiology
KW - air pollution
KW - Severity of Illness Index
KW - Young Adult
KW - Odds Ratio
KW - Patient Admission
KW - Humans
KW - Particle Size
KW - Pregnancy
KW - Environmental Monitoring
KW - Logistic Models
KW - Risk Factors
KW - Adult
KW - Case-Control Studies
KW - United States -- epidemiology
KW - Time Factors
KW - Female
KW - Delivery, Obstetric
KW - Hypertension, Pregnancy-Induced -- physiopathology
KW - Blood Pressure
KW - Hypertension, Pregnancy-Induced -- diagnosis
KW - Particulate Matter -- adverse effects
KW - Hypertension, Pregnancy-Induced -- epidemiology
KW - Environmental Exposure -- adverse effects
KW - Air Pollutants -- adverse effects
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hypertension&rft.atitle=Acute+air+pollution+exposure+and+blood+pressure+at+delivery+among+women+with+and+without+hypertension.&rft.au=M%C3%A4nnist%C3%B6%2C+Tuija%3BMendola%2C+Pauline%3BLiu%2C+Danping%3BLeishear%2C+Kira%3BSherman%2C+Seth%3BLaughon%2C+S+Katherine&rft.aulast=M%C3%A4nnist%C3%B6&rft.aufirst=Tuija&rft.date=2015-01-01&rft.volume=28&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hypertension&rft.issn=1941-7225&rft_id=info:doi/10.1093%2Fajh%2Fhpu077
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-21
N1 - Date created - 2014-12-16
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Obstet Gynecol. 2013 Nov;122(5):1122-31 [24150027]
Hypertension. 2003 Dec;42(6):1206-52 [14656957]
Lancet. 1997 May 31;349(9065):1582-7 [9174559]
Environ Health Perspect. 2005 Aug;113(8):1052-5 [16079078]
Epidemiology. 2005 Nov;16(6):744-50 [16222163]
Ann Emerg Med. 2008 Mar;51(3):221-9 [18207606]
Hypertension. 2009 May;53(5):853-9 [19273743]
Hypertension. 2009 Sep;54(3):659-67 [19620518]
Circulation. 2010 Jun 1;121(21):2331-78 [20458016]
Occup Environ Med. 2010 Sep;67(9):625-30 [20519749]
Am J Obstet Gynecol. 2010 Oct;203(4):326.e1-326.e10 [20708166]
Hypertension. 2011 Mar;57(3):406-12 [21220700]
Epidemiology. 2011 Jul;22(4):524-31 [21516040]
Environ Res. 2011 Jul;111(5):685-92 [21453913]
Epidemiology. 2011 Sep;22(5):671-9 [21730862]
Environ Res. 2011 Nov;111(8):1309-12 [22000598]
Women Health. 2011 Nov 30;51(8):724-38 [22185288]
Epidemiology. 2012 Mar;23(2):341-8 [22249240]
Hypertension. 2012 May;59(5):943-8 [22431582]
Hypertension. 2012 Jun;59(6):1241-8 [22526257]
Cardiol Clin. 2012 Aug;30(3):317-29 [22813360]
Cardiovasc Toxicol. 2012 Sep;12(3):216-25 [22328329]
Am J Epidemiol. 2012 Aug 15;176(4):308-16 [22811493]
Environ Res. 2012 Aug;117:60-7 [22717264]
Environ Res. 2012 Aug;117:46-53 [22835955]
Circulation. 2013 Feb 12;127(6):681-90 [23401113]
Matern Child Health J. 2013 Apr;17(3):545-55 [22544506]
Environ Res. 2013 May;123:9-16 [23522615]
Environ Pollut. 2013 Dec;183:30-9 [23369806]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/ajh/hpu077
ER -
TY - JOUR
T1 - Fibrillation of β amyloid peptides in the presence of phospholipid bilayers and the consequent membrane disruption.
AN - 1634726169; 24769158
AB - Fibrillation of β amyloid (Aβ) peptides and the accumulation of amyloid plaques are considered as an important clinical hallmark to identify Alzheimer's disease (AD). The physiological connection between Aβ plaques and the disruption of neuronal cells has not been clearly understood. One hypothesis to explain the Aβ neurotoxicity is that the fibrillation process induces disruption to the cellular membrane. We studied the Aβ fibrillation process in two biologically relevant conditions with the peptide either pre-incorporated into or externally added to the synthetic phospholipid bilayers. These two sample preparation conditions mimic the physiological membrane proximities of Aβ peptides before and after the enzymatic cleavage of amyloid precursor protein (APP). Using thioflavin T (ThT) fluorescence and transmission electron microscopy (TEM), we were able to monitor the kinetics and morphological evolution of fibril formation, which was highly sensitive to the two sample preparation protocols. While the external addition protocol generates long and mature fibrils through normal fibrillation process, the pre-incubation protocol was found to stabilize the immature protofibrils. Fluorescence spectroscopy studies with doubly-labeled phospholipids indicated that there may be a lipid uptake process associated with the fibril formation. Solid state nuclear magnetic resonance (NMR) spectroscopy provided evidence for high resolution structural variations in fibrils formed with different protocols, and in particular the stabilization of long-range contact between N- and C-terminal β strands. In addition, disruption of phospholipid bilayers was supported by measurements with ³¹P chemical shifts and relaxation time constants.
Copyright © 2014 Elsevier B.V. All rights reserved.
JF - Biochimica et biophysica acta
AU - Qiang, Wei
AU - Yau, Wai-Ming
AU - Schulte, Jürgen
AD - Department of Chemistry, Binghamton University, State University of New York, Binghamton, NY 13902-6000, USA; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA. Electronic address: wqiang@binghamton.edu. ; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA. ; Department of Chemistry, Binghamton University, State University of New York, Binghamton, NY 13902-6000, USA.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 266
EP - 276
VL - 1848
IS - 1 Pt B
SN - 0006-3002, 0006-3002
KW - Amyloid beta-Peptides
KW - 0
KW - Lipid Bilayers
KW - Phospholipids
KW - Index Medicus
KW - Alzheimer's disease
KW - β amyloid fibril
KW - Solid state NMR
KW - Membrane disruption
KW - Neurotoxicity mechanism
KW - Protein Aggregation, Pathological
KW - Models, Biological
KW - Magnetic Resonance Spectroscopy
KW - Phospholipids -- chemistry
KW - Amyloid beta-Peptides -- toxicity
KW - Amyloid beta-Peptides -- chemistry
KW - Lipid Bilayers -- chemistry
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1634726169?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Fibrillation+of+%CE%B2+amyloid+peptides+in+the+presence+of+phospholipid+bilayers+and+the+consequent+membrane+disruption.&rft.au=Qiang%2C+Wei%3BYau%2C+Wai-Ming%3BSchulte%2C+J%C3%BCrgen&rft.aulast=Qiang&rft.aufirst=Wei&rft.date=2015-01-01&rft.volume=1848&rft.issue=1+Pt+B&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbamem.2014.04.011
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-12
N1 - Date created - 2014-12-06
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.bbamem.2014.04.011
ER -
TY - JOUR
T1 - Nucleocytoplasmic shuttling of valosin-containing protein (VCP/p97) regulated by its N domain and C-terminal region.
AN - 1629968055; 25447673
AB - Valosin-containing protein (VCP or p97), a member of the AAA family (ATPases associated with diverse cellular activities), plays a key role in many important cellular activities. A genetic deficiency of VCP can cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD). Previous studies showed that the VCP N domain is essential for the regulation of nuclear entry of VCP. Here we report that IBMPFD mutations, which are mainly located in the N domain, suppress the nuclear entry of VCP. Moreover, the peptide sequence G780AGPSQ in the C-terminal region regulates the retention of VCP in the nucleus. A mutant lacking this sequence can increase the nuclear distribution of IBMPFD VCP, suggesting that this sequence is a potential molecular target for correcting the deficient nucleocytoplasmic shuttling of IBMPFD VCP proteins.
Copyright © 2014 Elsevier B.V. All rights reserved.
JF - Biochimica et biophysica acta
AU - Song, Changcheng
AU - Wang, Qing
AU - Song, Changzheng
AU - Lockett, Stephen J
AU - Colburn, Nancy H
AU - Li, Chou-Chi H
AU - Wang, Ji Ming
AU - Rogers, Thomas J
AD - Center for Inflammation, Translational and Clinical Lung Research, School of Medicine, Temple University, Philadelphia, PA 19140, USA. Electronic address: songc@temple.edu. ; Graduate Center for Toxicology, University of Kentucky, Lexington, KY, USA. ; Erythrocrine Project of Translational Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China. ; Optical Microscopy and Analysis Laboratory, Advanced Technology Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA. ; Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Frederick, MD 21702, USA. ; Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Basic Research Program, SAIC-Frederick Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA. ; Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA. ; Center for Inflammation, Translational and Clinical Lung Research, School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 222
EP - 232
VL - 1853
IS - 1
SN - 0006-3002, 0006-3002
KW - Cell Cycle Proteins
KW - 0
KW - Adenosine Triphosphatases
KW - EC 3.6.1.-
KW - CDC48 protein
KW - Index Medicus
KW - Valosin containing protein
KW - Nucleocytoplasmic shuttling
KW - Nuclear export signal
KW - Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD)
KW - Osteitis Deformans -- genetics
KW - Active Transport, Cell Nucleus
KW - Humans
KW - HEK293 Cells
KW - Muscular Dystrophies, Limb-Girdle -- genetics
KW - Frontotemporal Dementia -- genetics
KW - Protein Structure, Tertiary
KW - Myositis, Inclusion Body -- genetics
KW - Cell Cycle Proteins -- chemistry
KW - Cell Cycle Proteins -- genetics
KW - Cell Nucleus -- metabolism
KW - Adenosine Triphosphatases -- physiology
KW - Adenosine Triphosphatases -- metabolism
KW - Adenosine Triphosphatases -- chemistry
KW - Adenosine Triphosphatases -- genetics
KW - Cell Cycle Proteins -- metabolism
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Nucleocytoplasmic+shuttling+of+valosin-containing+protein+%28VCP%2Fp97%29+regulated+by+its+N+domain+and+C-terminal+region.&rft.au=Song%2C+Changcheng%3BWang%2C+Qing%3BSong%2C+Changzheng%3BLockett%2C+Stephen+J%3BColburn%2C+Nancy+H%3BLi%2C+Chou-Chi+H%3BWang%2C+Ji+Ming%3BRogers%2C+Thomas+J&rft.aulast=Song&rft.aufirst=Changcheng&rft.date=2015-01-01&rft.volume=1853&rft.issue=1&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbamcr.2014.10.019
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-01-29
N1 - Date created - 2014-12-03
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Oncogene. 2011 Feb 17;30(7):790-805 [20956947]
Biochem Biophys Res Commun. 2003 Jan 10;300(2):253-60 [12504076]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.bbamcr.2014.10.019
ER -
TY - JOUR
T1 - Conformational dynamics and aggregation behavior of piezoelectric diphenylalanine peptides in an external electric field.
AN - 1629964930; 25240398
AB - Aromatic peptides including diphenylalanine (FF) have the capacity to self-assemble into ordered, biocompatible nanostructures with piezoelectric properties relevant to a variety of biomedical applications. Electric fields are commonly applied to align FF nanotubes, yet little is known about the effect of the electric field on the assembly process. Using all-atom molecular dynamics with explicit water molecules, we examine the response of FF monomers to the application of a constant external electric field over a range of intensities. We probe the aggregation mechanism of FF peptides, and find that the presence of even relatively weak fields can accelerate ordered aggregation, primarily by facilitating the alignment of individual molecular dipole moments. This is modulated by the conformational response of individual FF peptides (e.g., backbone stretching) and by the cooperative alignment of neighboring FF and water molecules. These observations may facilitate future studies on the controlled formation of nanostructured aggregates of piezoelectric peptides and the understanding of their electro-mechanical properties.
Copyright © 2014 Elsevier B.V. All rights reserved.
JF - Biophysical chemistry
AU - Kelly, Catherine M
AU - Northey, Thomas
AU - Ryan, Kate
AU - Brooks, Bernard R
AU - Kholkin, Andrei L
AU - Rodriguez, Brian J
AU - Buchete, Nicolae-Viorel
AD - School of Physics, University College Dublin, Belfield, Dublin 4, Ireland; Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin 4, Ireland. ; School of Physics, University College Dublin, Belfield, Dublin 4, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. ; Laboratory of Computational Biology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, United States. ; Department of Materials and Ceramic Engineering & CICECO, University of Aveiro, Portugal. ; School of Physics, University College Dublin, Belfield, Dublin 4, Ireland; Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: buchete@ucd.ie.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 16
EP - 24
VL - 196
KW - Solvents
KW - 0
KW - diphenylalanine
KW - Phenylalanine
KW - 47E5O17Y3R
KW - Index Medicus
KW - Peptide aggregate
KW - Peptide–peptide interaction
KW - Atomistic molecular dynamics
KW - Piezoelectric peptide
KW - Diphenylalanine peptide
KW - External electric field
KW - Solvents -- chemistry
KW - Nanostructures -- chemistry
KW - Electricity
KW - Protein Structure, Tertiary
KW - Hydrogen Bonding
KW - Phenylalanine -- chemistry
KW - Phenylalanine -- analogs & derivatives
KW - Molecular Dynamics Simulation
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629964930?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+chemistry&rft.atitle=Conformational+dynamics+and+aggregation+behavior+of+piezoelectric+diphenylalanine+peptides+in+an+external+electric+field.&rft.au=Kelly%2C+Catherine+M%3BNorthey%2C+Thomas%3BRyan%2C+Kate%3BBrooks%2C+Bernard+R%3BKholkin%2C+Andrei+L%3BRodriguez%2C+Brian+J%3BBuchete%2C+Nicolae-Viorel&rft.aulast=Kelly&rft.aufirst=Catherine&rft.date=2015-01-01&rft.volume=196&rft.issue=&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Biophysical+chemistry&rft.issn=1873-4200&rft_id=info:doi/10.1016%2Fj.bpc.2014.08.009
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-27
N1 - Date created - 2014-12-03
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.bpc.2014.08.009
ER -
TY - JOUR
T1 - Alcohol and breast cancer: reconciling epidemiological and molecular data.
AN - 1628878280; 25427899
AB - Breast cancer is the most diagnosed cancer in women worldwide. Epidemiological studies have suggested a possible causative role of alcohol consumption as a risk factor for breast cancer. However, such conclusions should be interpreted with considerable caution for several reasons. While epidemiological studies can help identify the roots of health problems and disease incidence in a community, they are by necessity associative and cannot determine cause and effect relationships. In addition, all these studies rely on self-reporting to determine the amount and type of alcoholic beverage consumed, which introduces recall bias. This is documented in a recent study which stated that the apparent increased risk of cancer among light-moderate drinkers may be "substantially due to underreporting of intake." Another meta-analysis about alcohol and breast cancer declared "the modest size of the association and variation in results across studies leave the causal role of alcohol in question." Furthermore, breast cancer develops over decades; thus, correlations between alcohol consumption and breast cancer cannot be determined in epidemiological studies with windows of alcohol exposure that captures current or recent alcohol intake, after clinical diagnosis. Numerous risk factors are involved in breast carcinogenesis; some are genetic and beyond the control of a woman; others are influenced by lifestyle factors. Breast cancer is a heterogeneous and polygenic disease which is further influenced by epigenetic mechanisms that affect the transciptomes, proteomes and metabolomes, and ultimately breast cancer evolution. Environmental factors add another layer of complexity by their interactions with the susceptibility genes for breast cancer and metabolic diseases. The current state-of-knowledge about alcohol and breast cancer association is ambiguous and confusing to both a woman and her physician. Confronting the huge global breast cancer issue should be addressed by sound science. It is advised that women with or without a high risk for breast cancer should avoid overconsumption of alcohol and should consult with their physician about risk factors involved in breast cancer. Since studies associating moderate alcohol consumption and breast cancer are contradictory, a woman and her physician should weigh the risks and benefits of moderate alcohol consumption.
JF - Advances in experimental medicine and biology
AU - Zakhari, Samir
AU - Hoek, Jan B
AD - Former Director, Division of Metabolism and Health Effects, NIAAA, NIH, Bethesda, MD, 20852, USA, szakhari@discus.org.
Y1 - 2015
PY - 2015
DA - 2015
SP - 7
EP - 39
VL - 815
SN - 0065-2598, 0065-2598
KW - Estrogens
KW - 0
KW - Ethanol
KW - 3K9958V90M
KW - Folic Acid
KW - 935E97BOY8
KW - Index Medicus
KW - Folic Acid -- metabolism
KW - Estrogens -- metabolism
KW - Epidemiologic Studies
KW - Risk Factors
KW - Humans
KW - Female
KW - Ethanol -- toxicity
KW - Ethanol -- metabolism
KW - Breast Neoplasms -- chemically induced
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1628878280?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=Alcohol+and+breast+cancer%3A+reconciling+epidemiological+and+molecular+data.&rft.au=Zakhari%2C+Samir%3BHoek%2C+Jan+B&rft.aulast=Zakhari&rft.aufirst=Samir&rft.date=2015-01-01&rft.volume=815&rft.issue=&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/10.1007%2F978-3-319-09614-8_2
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-03-23
N1 - Date created - 2014-11-27
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1007/978-3-319-09614-8_2
ER -
TY - JOUR
T1 - Microglial regulation of immunological and neuroprotective functions of astroglia.
AN - 1627078775; 25130274
AB - Microglia and astroglia play critical roles in the development, function, and survival of neurons in the CNS. However, under inflammatory conditions the role of astrogliosis in the inflammatory process and its effects on neurons remains unclear. Here, we used several types of cell cultures treated with the bacterial inflammogen LPS to address these questions. We found that the presence of astroglia reduced inflammation-driven neurotoxicity, suggesting that astrogliosis is principally neuroprotective. Neutralization of supernatant glial cell line-derived neurotrophic factor (GDNF) released from astroglia significantly reduced this neuroprotective effect during inflammation. To determine the immunological role of astroglia, we optimized a highly-enriched astroglial culture protocol and demonstrated that LPS failed to induce the synthesis and release of TNF-α and iNOS/NO. Instead we found significant enhancement of TNF-α and iNOS expression in highly-enriched astroglial cultures required the presence of 0.5-1% microglia, respectively. Thus suggesting that microglial-astroglial interactions are required for LPS to induce the expression of pro-inflammatory factors and GDNF from astroglia. Specifically, we found that microglia-derived TNF-α plays a pivotal role as a paracrine signal to regulate the neuroprotective functions of astrogliosis. Taken together, these findings suggest that astroglia may not possess the ability to directly recognize the innate immune stimuli LPS, but rather depend on crosstalk with microglia to elicit release of neurotrophic factors as a counterbalance to support neuronal survival from the collateral damage generated by activated microglia during neuroinflammation.
© 2014 Wiley Periodicals, Inc.
JF - Glia
AU - Chen, Shih-Heng
AU - Oyarzabal, Esteban A
AU - Sung, Yueh-Feng
AU - Chu, Chun-Hsien
AU - Wang, Qingshan
AU - Chen, Shiou-Lan
AU - Lu, Ru-Band
AU - Hong, Jau-Shyong
AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Y1 - 2015/01//
PY - 2015
DA - January 2015
SP - 118
EP - 131
VL - 63
IS - 1
KW - Glial Cell Line-Derived Neurotrophic Factor
KW - 0
KW - Lipopolysaccharides
KW - Tumor Necrosis Factor-alpha
KW - Index Medicus
KW - astroglia
KW - microglia
KW - glial cell line-derived neurotrophic factor
KW - neuroprotection
KW - glial interaction
KW - neuroinflammation
KW - Gliosis -- metabolism
KW - Animals
KW - Rats, Inbred F344
KW - Glial Cell Line-Derived Neurotrophic Factor -- metabolism
KW - Cells, Cultured
KW - Lipopolysaccharides -- pharmacology
KW - Tumor Necrosis Factor-alpha -- metabolism
KW - Female
KW - Neurons -- metabolism
KW - Microglia -- immunology
KW - Astrocytes -- immunology
KW - Microglia -- metabolism
KW - Astrocytes -- metabolism
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627078775?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=Microglial+regulation+of+immunological+and+neuroprotective+functions+of+astroglia.&rft.au=Chen%2C+Shih-Heng%3BOyarzabal%2C+Esteban+A%3BSung%2C+Yueh-Feng%3BChu%2C+Chun-Hsien%3BWang%2C+Qingshan%3BChen%2C+Shiou-Lan%3BLu%2C+Ru-Band%3BHong%2C+Jau-Shyong&rft.aulast=Chen&rft.aufirst=Shih-Heng&rft.date=2015-01-01&rft.volume=63&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=1098-1136&rft_id=info:doi/10.1002%2Fglia.22738
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-14
N1 - Date created - 2014-11-21
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1002/glia.22738
ER -
TY - JOUR
T1 - Identifying gender differences in reported occupational information from three US population-based case-control studies
AN - 1808615939; PQ0003453858
AB - ObjectivesGrowing evidence suggests that gender-blind assessment of exposure may introduce exposure misclassification, but few studies have characterised gender differences across occupations and industries. We pooled control responses to job-specific, industry-specific and exposure-specific questionnaires (modules) that asked detailed questions about work activities from three US population-based case-control studies to examine gender differences in work tasks and their frequencies.MethodsWe calculated the ratio of female-to-male controls that completed each module. For four job modules (assembly worker, machinist, health professional, janitor/cleaner) and for subgroups of jobs that completed those modules, we evaluated gender differences in task prevalence and frequency using chi 2 and Mann-Whitney U tests, respectively.ResultsThe 1360 female and 2245 male controls reported 6033 and 12083 jobs, respectively. Gender differences in female:male module completion ratios were observed for 39 of 45 modules completed by greater than or equal to 20 controls. Gender differences in task prevalence varied in direction and magnitude. For example, female janitors were significantly more likely to polish furniture (79% vs 44%), while male janitors were more likely to strip floors (73% vs 50%). Women usually reported more time spent on tasks than men. For example, the median hours per week spent degreasing for production workers in product manufacturing industries was 6.3 for women and 3.0 for men.ConclusionsObserved gender differences may reflect actual differences in tasks performed or differences in recall, reporting or perception, all of which contribute to exposure misclassification and impact relative risk estimates. Our findings reinforce the need to capture subject-specific information on work tasks.
JF - Occupational and Environmental Medicine
AU - Locke, Sarah J
AU - Colt, Joanne S
AU - Stewart, Patricia A
AU - Armenti, Karla R
AU - Baris, Dalsu
AU - Blair, Aaron
AU - Cerhan, James R
AU - Chow, Wong-Ho
AU - Cozen, Wendy
AU - Davis, Faith
AU - De Roos, Anneclaire J
AU - Hartge, Patricia
AU - Karagas, Margaret R
AU - Johnson, Alison
AU - Purdue, Mark P
AU - Rothman, Nathaniel
AU - Schwartz, Kendra
AU - Schwenn, Molly
AU - Severson, Richard
AU - Silverman, Debra T
AU - Friesen, Melissa C
AD - Occupational and Environmental Epidemiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
Y1 - 2014/12/28/
PY - 2014
DA - 2014 Dec 28
SP - 855
EP - 864
PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom
VL - 71
IS - 12
SN - 1351-0711, 1351-0711
KW - Toxicology Abstracts; Health & Safety Science Abstracts
KW - population-based studies
KW - case-control studies
KW - occupational exposure
KW - occupational health
KW - Risk assessment
KW - Manufacturing industry
KW - Inventories
KW - Sex differences
KW - Workers
KW - Perception
KW - Gender
KW - Cleaning process
KW - Occupational exposure
KW - H 1000:Occupational Safety and Health
KW - X 24350:Industrial Chemicals
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808615939?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Identifying+gender+differences+in+reported+occupational+information+from+three+US+population-based+case-control+studies&rft.au=Locke%2C+Sarah+J%3BColt%2C+Joanne+S%3BStewart%2C+Patricia+A%3BArmenti%2C+Karla+R%3BBaris%2C+Dalsu%3BBlair%2C+Aaron%3BCerhan%2C+James+R%3BChow%2C+Wong-Ho%3BCozen%2C+Wendy%3BDavis%2C+Faith%3BDe+Roos%2C+Anneclaire+J%3BHartge%2C+Patricia%3BKaragas%2C+Margaret+R%3BJohnson%2C+Alison%3BPurdue%2C+Mark+P%3BRothman%2C+Nathaniel%3BSchwartz%2C+Kendra%3BSchwenn%2C+Molly%3BSeverson%2C+Richard%3BSilverman%2C+Debra+T%3BFriesen%2C+Melissa+C&rft.aulast=Locke&rft.aufirst=Sarah&rft.date=2014-12-28&rft.volume=71&rft.issue=12&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2013-101801
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-07-01
N1 - Last updated - 2016-09-01
N1 - SubjectsTermNotLitGenreText - Risk assessment; Workers; Inventories; Perception; Sex differences; Occupational exposure; Manufacturing industry; Gender; Cleaning process
DO - http://dx.doi.org/10.1136/oemed-2013-101801
ER -
TY - JOUR
T1 - Work history and mortality risks in 90268 US radiological technologists
AN - 1808717972; PQ0003453839
AB - ObjectivesThere have been few studies of work history and mortality risks in medical radiation workers. We expanded by 11years and more outcomes our previous study of mortality risks and work history, a proxy for radiation exposure.MethodsUsing Cox proportional hazards models, we estimated mortality risks according to questionnaire work history responses from 1983 to 1989 through 2008 by 90268 US radiological technologists. We controlled for potential confounding by age, birth year, smoking history, body mass index, race and gender.ResultsThere were 9566 deaths (3329 cancer and 3020 circulatory system diseases). Mortality risks increased significantly with earlier year began working for female breast (p trend=0.01) and stomach cancers (p trend=0.01), ischaemic heart (p trend=0.03) and cerebrovascular diseases (p trend=0.02). The significant trend with earlier year first worked was strongly apparent for breast cancer during baseline through 1997, but not 1998-2008. Risks were similar in the two periods for circulatory diseases. Radiological technologists working greater than or equal to 5years before 1950 had elevated mortality from breast cancer (HR=2.05, 95% CI 1.27 to 3.32), leukaemia (HR=2.57, 95% CI 0.96 to 6.68), ischaemic heart disease (HR=1.13, 95% CI 0.96 to 1.33) and cerebrovascular disease (HR=1.28, 95% CI 0.97 to 1.69). No other work history factors were consistently associated with mortality risks from specific cancers or circulatory diseases, or other conditions.ConclusionsRadiological technologists who began working in early periods and for more years before 1950 had increased mortality from a few cancers and some circulatory system diseases, likely reflecting higher occupational radiation exposures in the earlier years.
JF - Occupational and Environmental Medicine
AU - Liu, Jason J
AU - Freedman, D Michal
AU - Little, Mark P
AU - Doody, Michele M
AU - Alexander, Bruce H
AU - Kitahara, Cari M
AU - Lee, Terrence
AU - Rajaraman, Preetha
AU - Miller, Jeremy S
AU - Kampa, Diane M
AU - Simon, Steven L
AU - Preston, Dale L
AU - Linet, Martha S
AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
Y1 - 2014/12/22/
PY - 2014
DA - 2014 Dec 22
SP - 819
EP - 835
PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom
VL - 71
IS - 12
SN - 1351-0711, 1351-0711
KW - Health & Safety Science Abstracts
KW - mortality
KW - neoplasms
KW - circulatory system diseases
KW - radiologic technologists
KW - work history
KW - Historical account
KW - Mortality
KW - Age
KW - Body mass
KW - Cancer
KW - Smoking
KW - Leukemia
KW - Health risks
KW - Radiation
KW - Risk factors
KW - Breast cancer
KW - Occupational exposure
KW - Heart diseases
KW - H 1000:Occupational Safety and Health
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-07-01
N1 - Last updated - 2016-09-01
N1 - SubjectsTermNotLitGenreText - Mortality; Historical account; Age; Body mass; Cancer; Health risks; Leukemia; Smoking; Radiation; Risk factors; Breast cancer; Occupational exposure; Heart diseases
DO - http://dx.doi.org/10.1136/oemed-2013-101859
ER -
TY - JOUR
T1 - Photo activation of HPPH encapsulated in "Pocket" liposomes triggers multiple drug release and tumor cell killing in mouse breast cancer xenografts
AN - 1647009351; 21327245
AB - We recently reported laser-triggered release of photosensitive compounds from liposomes containing dipalmitoylphosphatidylcholine (DPPC) and 1,2 bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC). We hypothesized that the permeation of photoactivated compounds occurs through domains of enhanced fluidity in the liposome membrane and have thus called them "Pocket" liposomes. In this study we have encapsulated the red light activatable anticancer photodynamic therapy drug 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) (Ex/Em410/670 nm) together with calcein (Ex/Em490/517 nm) as a marker for drug release in Pocket liposomes. A mole ratio of 7.6:1 lipid:HPPH was found to be optimal, with >80% of HPPH being included in the liposomes. Exposure of liposomes with a cw-diode 660 nm laser (90 mW, 0-5 minutes) resulted in calcein release only when HPPH was included in the liposomes. Further analysis of the quenching ratios of liposome-entrapped calcein in the laser treated samples indicated that the laser-triggered release occurred via the graded mechanism. In vitro studies with MDA-MB-231-LM2 breast cancer cell line showed significant cell killing upon treatment of cell-liposome suspensions with the laser. To assess in vivo efficacy, we implanted MDA-MB-231-LM2 cells containing the luciferase gene along the mammary fat pads on the ribcage of mice. For biodistribution experiments, trace amounts of a near infrared lipid probe DiR (Ex/Em745/840 nm) were included in the liposomes. Liposomes were injected intravenously and laser treatments (90 mW, 0.9 cm diameter, for an exposure duration ranging from 5-8 minutes) were done 4 hours postinjection (only one tumor per mouse was treated, keeping the second flank tumor as control). Calcein release occurred as indicated by an increase in calcein fluorescence from laser treated tumors only. The animals were observed for up to 15 days postinjection and tumor volume and luciferase expression was measured. A significant decrease in luciferase expression and reduction in tumor volume was observed only in laser treated animal groups injected with liposomes containing HPPH. Histopathological examination of tumor tissues indicated tumor necrosis resulting from laser treatment of the HPPH-encapsulated liposomes that were taken up into the tumor area.
JF - International Journal of Nanomedicine
AU - Sine, Jessica
AU - Urban, Cordula
AU - Thayer, Derek
AU - Charron, Heather
AU - Valim, Niksa
AU - Tata, Darrell B
AU - Schiff, Rachel
AU - Blumenthal, Robert
AU - Joshi, Amit
AU - Puri, Anu
AD - Membrane Structure and Function Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute - Frederick, Frederick, MD, USA
Y1 - 2014/12/19/
PY - 2014
DA - 2014 Dec 19
SP - 125
EP - 145
PB - Dove Medical Press Ltd, Beechfield House Macclesfield SK11 0JL United Kingdom
VL - 10
SN - 1176-9114, 1176-9114
KW - Biotechnology and Bioengineering Abstracts
KW - laser-triggered payload release
KW - photo-agents
KW - photopolymerizable phospholipids
KW - tumor regression
KW - phototriggering
KW - Drug delivery
KW - Fluorescence
KW - Fluidity
KW - Calcein
KW - Lipids
KW - photodynamic therapy
KW - Tumors
KW - Liposomes
KW - Tumor cells
KW - Light effects
KW - Tumor cell lines
KW - Necrosis
KW - Fluorescent indicators
KW - Breast cancer
KW - Lasers
KW - Xenografts
KW - nanotechnology
KW - W 30915:Pharmaceuticals & Vaccines
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Nanomedicine&rft.atitle=Photo+activation+of+HPPH+encapsulated+in+%22Pocket%22+liposomes+triggers+multiple+drug+release+and+tumor+cell+killing+in+mouse+breast+cancer+xenografts&rft.au=Sine%2C+Jessica%3BUrban%2C+Cordula%3BThayer%2C+Derek%3BCharron%2C+Heather%3BValim%2C+Niksa%3BTata%2C+Darrell+B%3BSchiff%2C+Rachel%3BBlumenthal%2C+Robert%3BJoshi%2C+Amit%3BPuri%2C+Anu&rft.aulast=Sine&rft.aufirst=Jessica&rft.date=2014-12-19&rft.volume=10&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Nanomedicine&rft.issn=11769114&rft_id=info:doi/10.2147%2FIJN.S72143
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-01-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Drug delivery; Fluidity; Fluorescence; Calcein; Lipids; photodynamic therapy; Tumors; Tumor cells; Liposomes; Light effects; Necrosis; Tumor cell lines; Breast cancer; Fluorescent indicators; Lasers; Xenografts; nanotechnology
DO - http://dx.doi.org/10.2147/IJN.S72143
ER -
TY - JOUR
T1 - Pre-immature dendritic cells (PIDC) pulsed with HPV16 E6 or E7 peptide are capable of eliciting specific immune response in patients with advanced cervical cancer.
AN - 1639972742; 25510844
AB - The protein products of the early genes E6 and E7 in high-risk HPV types 16 and 18 have been implicated in the oncogenic capability of these viruses. Therefore, these peptides represent attractive vaccine therapy targets. Thirty-two patients with advanced cervical cancer (HPV16 or 18 positive) were treated with HPV16 E6 (18-26) (Arm A) or HPV16 E7 (12-20) peptide (Arm B) pulsed on PBMCs in order to illicit immune response against the relevant peptide on both arms. These PBMCs were cultured for a short time (48 hours only) and in the presence of GM- CSF, accordingly, they were identified as "Pre-Immature Dentritic Cells".
51Cr release assay and ELISPOT demonstrated evidence of specific immune response against the relevant peptide in 10/16 (63%) evaluable patients in arm A and 7/12 (58%) in arm B. HPV16 E6 was found to be homologous to HPV18 E6 in both vivo and vitro. The median overall survival (OS) and progression free survival (PFS) for the full cohort was 10.0 and 3.5 months, respectively. There were no RECIST responses in any patient. The majority of toxicities were grade I and II. We demonstrated the feasibility and ability of Pre-Immature Dentritic Cells pulsed with HPV16 E6 (18-26) or HPV16 E7 (12-20) to induce a specific immune response against the relevant peptide despite the advanced disease of the cervical cancer patients treated on this trial. We believe that this observation deserves further investigations.
JF - Journal of translational medicine
AU - Rahma, Osama E
AU - Herrin, Vincent E
AU - Ibrahim, Rami A
AU - Toubaji, Anton
AU - Bernstein, Sarah
AU - Dakheel, Omar
AU - Steinberg, Seth M
AU - Abu Eid, Rasha
AU - Mkrtichyan, Mikayel
AU - Berzofsky, Jay A
AU - Khleif, Samir N
AD - Cancer Vaccine Branch, CCR, NCI, 10 Center Drive, Bethesda 20892, MD, USA. skhleif@gru.edu.
Y1 - 2014/12/16/
PY - 2014
DA - 2014 Dec 16
SP - 353
VL - 12
KW - Cancer Vaccines
KW - 0
KW - E6 protein, Human papillomavirus type 16
KW - Oncogene Proteins, Viral
KW - Papillomavirus E7 Proteins
KW - Repressor Proteins
KW - oncogene protein E7, Human papillomavirus type 16
KW - Index Medicus
KW - Humans
KW - Adult
KW - Middle Aged
KW - Female
KW - Papillomavirus E7 Proteins -- administration & dosage
KW - Uterine Cervical Neoplasms -- therapy
KW - Dendritic Cells -- immunology
KW - Cancer Vaccines -- immunology
KW - Oncogene Proteins, Viral -- immunology
KW - Repressor Proteins -- administration & dosage
KW - Cancer Vaccines -- therapeutic use
KW - Repressor Proteins -- immunology
KW - Uterine Cervical Neoplasms -- immunology
KW - Oncogene Proteins, Viral -- administration & dosage
KW - Papillomavirus E7 Proteins -- immunology
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-15
N1 - Date created - 2014-12-18
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Int J Oncol. 2001 Mar;18(3):475-8 [11179474]
Cancer Immunol Immunother. 2012 Mar;61(3):373-84 [21927947]
J Cancer Res Clin Oncol. 2003 Sep;129(9):521-30 [12898233]
Ann Oncol. 2004 Feb;15(2):197-200 [14760108]
J Clin Oncol. 2004 Aug 1;22(15):3113-9 [15284262]
Hum Pathol. 2004 Aug;35(8):971-82 [15297964]
J Virol. 2004 Nov;78(21):11451-60 [15479788]
Lancet. 1996 Jun 1;347(9014):1523-7 [8684105]
J Exp Med. 1997 Oct 20;186(8):1183-7 [9379142]
Nature. 1998 Mar 19;392(6673):245-52 [9521319]
J Pathol. 1999 Sep;189(1):12-9 [10451482]
Lancet Oncol. 2005 May;6(5):271-8 [15863374]
J Clin Oncol. 2005 Jul 20;23(21):4626-33 [15911865]
Gynecol Oncol. 2006 Mar;100(3):469-78 [16249018]
J Clin Virol. 2007 Mar;38(3):189-97 [17258503]
Lung Cancer. 2007 Apr;56(1):135-7 [17157952]
J Clin Invest. 2007 May;117(5):1195-203 [17476349]
Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118]
Lancet. 2007 Jun 2;369(9576):1861-8 [17544766]
Sex Health. 2007 Sep;4(3):147-63 [17931528]
Curr Mol Med. 2009 Aug;9(6):766-73 [19689303]
N Engl J Med. 2009 Nov 5;361(19):1838-47 [19890126]
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 [21296855]
Curr Opin Immunol. 2003 Apr;15(2):138-47 [12633662]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1186/s12967-014-0353-4
ER -
TY - JOUR
T1 - Reduced Prevalence of Vulvar HPV16/18 Infection Among Women Who Received the HPV16/18 Bivalent Vaccine: A Nested Analysis Within the Costa Rica Vaccine Trial
AN - 1687671860; PQ0001542370
AB - Background Vaccine efficacy (VE) against vulvar human papillomavirus (HPV) infection has not been reported and data regarding its epidemiology are sparse. Methods Women (n = 5404) age 22-29 present at the 4-year study visit of the Costa Rica Vaccine Trial provided vulvar and cervical samples. A subset (n = 1044) was tested for HPV DNA (SPF sub(10)/LiPA sub(25) version 1). VE against 1-time detection of vulvar HPV16/18 among HPV vaccinated versus unvaccinated women was calculated and compared to the cervix. Prevalence of and risk factors for HPV were evaluated in the control arm (n = 536). Results Vulvar HPV16/18 VE (54.1%; 95% confidence interval [CI], 4.9%-79.1%) was comparable to cervix (45.8%; 95% CI, 6.4%-69.4%). Vulvar and cervical HPV16 prevalence within the control arm was 3.0% and 4.7%, respectively. Independent risk factors for vulvar HPV were similar to cervix and included: age (adjusted odds ratio [aOR] 0.5 [95% CI, .3-.9] > or =28 vs 22-23]); marital status (aOR 2.3 [95% CI, 1.5-3.5] single vs married/living-as-married); and number of sexual partners (aOR 3.6 [95% CI, 1.9-7.0] > or =6 vs 1). Conclusions In this intention-to-treat analysis, VE against vulvar and cervical HPV16/18 were comparable 4 years following vaccination. Risk factors for HPV were similar by anatomic site.
JF - Journal of Infectious Diseases
AU - Kuhs, Krystle A Lang
AU - Gonzalez, Paula
AU - Rodriguez, Ana Cecilia
AU - van Doorn, Leen-Jan
AU - Schiffman, Mark
AU - Struijk, Linda
AU - Chen, Sabrina
AU - Quint, Wim
AU - Lowy, Douglas R
AU - Porras, Carolina
AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr, Rm 6-E210, Bethesda, MD 20892, krystle.kuhs@nih.gov
Y1 - 2014/12/15/
PY - 2014
DA - 2014 Dec 15
SP - 1890
EP - 1899
PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom
VL - 210
IS - 12
SN - 0022-1899, 0022-1899
KW - Genetics Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts; Risk Abstracts
KW - Costa Rica
KW - HPV
KW - HPV vaccine
KW - vulvar human papillomavirus vaccine
KW - Age
KW - Data processing
KW - Marriage
KW - Infection
KW - Clinical trials
KW - Sexual behavior
KW - Vaccination
KW - Sexual partners
KW - ASW, Costa Rica
KW - Infectious diseases
KW - Epidemiology
KW - Human papillomavirus 16
KW - Risk factors
KW - DNA
KW - Females
KW - Vaccines
KW - Cervix
KW - Human papillomavirus
KW - G 07720:Immunogenetics
KW - R2 23060:Medical and environmental health
KW - H 4000:Food and Drugs
KW - V 22400:Human Diseases
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-06-01
N1 - Last updated - 2016-04-13
N1 - SubjectsTermNotLitGenreText - Sexual partners; Age; Data processing; Epidemiology; Risk factors; DNA; Vaccines; Infection; Cervix; Vaccination; Infectious diseases; Marriage; Females; Sexual behavior; Clinical trials; Human papillomavirus 16; Human papillomavirus; ASW, Costa Rica
DO - http://dx.doi.org/10.1093/infdis/jiu357
ER -
TY - CPAPER
T1 - Making the connection: Federal efforts on climate change and health
T2 - 47th American Geophysical Union Fall Meeting
AN - 1651740165; 6329742
JF - 47th American Geophysical Union Fall Meeting
AU - Balbus, John
Y1 - 2014/12/15/
PY - 2014
DA - 2014 Dec 15
KW - Climatic changes
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L2 - https://agu.confex.com/agu/fm14/meetingapp.cgi#ModuleSessionsByDay/0
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-01-31
N1 - Last updated - 2015-02-06
ER -
TY - CPAPER
T1 - When the Well Runs Dry: Climate Change, Water and Human Health
T2 - 47th American Geophysical Union Fall Meeting
AN - 1651739632; 6330287
JF - 47th American Geophysical Union Fall Meeting
AU - Balbus, John
Y1 - 2014/12/15/
PY - 2014
DA - 2014 Dec 15
KW - Climatic changes
KW - Water wells
KW - Public health
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L2 - https://agu.confex.com/agu/fm14/meetingapp.cgi#ModuleSessionsByDay/0
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-01-31
N1 - Last updated - 2015-02-06
ER -
TY - JOUR
T1 - Anthracycline-free neoadjuvant therapy induces pathological complete responses by exploiting immune proficiency in HER2+ breast cancer patients.
AN - 1640327724; 25512030
AB - Neoadjuvant Chemotherapy (NC) including trastuzumab induces a high rate of pathological Complete Responses (pCR) in patients with locally advanced HER2-overexpressing Breast Cancer (BC), but is penalized by a severe cardiotoxicity when combined with anthracyclines. A phase II study was designed to assess whether an anthracycline-free NC regimen based on the early addition of trastuzumab to paclitaxel may increase the pCR rate without inducing severe cardiotoxicity in patients with locally advanced HER2-overexpressing BC. Immunomonitoring was performed to assess the contribution of patients' immunological background to the induction of clinical responses.
Stage II-III HER2-positive BC patients received 24 weeks paclitaxel and trastuzumab NC, followed by 1 year adjuvant trastuzumab ± hormonal and/or radio-therapy. Assessment of pCR rate was the primary endpoint. A group of HER2-negative BC patients treated with neoadjuvant taxanes and anthracyclines was included. Serum levels of 10 cytokines and the efficiency of trastuzumab-mediated antibody-dependent cell cytotoxicity (ADCC) were monitored in vitro every 3 months. From July 2006 to February 2013, we enrolled 109 patients including 46 evaluable HER2-positive cases. A pCR rate of 50% was reached and no severe cardiotoxicity occurred. Serum cytokine profiling revealed only an IL-10 decrease (P = 0.02) in patients achieving a partial response, while HER2-negative patients disclosed marked cytokines changes. Compared to the unfavourable F/F genotype, patients carrying the V allele in the FcγRIIIa-158 polymorphism showed a higher efficacy of trastuzumab-ADCC throughout treatment (P ≤0.05).
In the absence of anthracyclines, trastuzumab and paclitaxel induced a high rate of pCR, exploiting the synergy between the immunomodulating properties of these drugs and the retained immunological proficiency of patients with HER2-overexpressing BC.
Trial registration number: NCT02307227, registered on ClinicalTrials.gov (http://www.clinicaltrials.gov, November 26, 2014).
JF - BMC cancer
AU - Miolo, Gianmaria
AU - Muraro, Elena
AU - Martorelli, Debora
AU - Lombardi, Davide
AU - Scalone, Simona
AU - Spazzapan, Simon
AU - Massarut, Samuele
AU - Perin, Tiziana
AU - Viel, Elda
AU - Comaro, Elisa
AU - Talamini, Renato
AU - Bidoli, Ettore
AU - Turchet, Elisa
AU - Crivellari, Diana
AU - Dolcetti, Riccardo
AD - Cancer Bio-Immunotherapy Unit, Department of Medical Oncology, C,R,O, National Cancer Institute, Via F, Gallini 2, 33081 Aviano, PN, Italy. rdolcetti@cro.it.
Y1 - 2014/12/15/
PY - 2014
DA - 2014 Dec 15
SP - 954
VL - 14
KW - Antibodies, Monoclonal, Humanized
KW - 0
KW - Cytokines
KW - FCGR3A protein, human
KW - Receptors, IgG
KW - Receptor, ErbB-2
KW - EC 2.7.10.1
KW - Trastuzumab
KW - P188ANX8CK
KW - Paclitaxel
KW - P88XT4IS4D
KW - Index Medicus
KW - Cytokines -- blood
KW - Paclitaxel -- administration & dosage
KW - Young Adult
KW - Neoplasm Staging
KW - Receptor, ErbB-2 -- metabolism
KW - Polymorphism, Genetic
KW - Humans
KW - Neoadjuvant Therapy
KW - Aged
KW - Antibodies, Monoclonal, Humanized -- administration & dosage
KW - Adult
KW - Treatment Outcome
KW - Middle Aged
KW - Antibody-Dependent Cell Cytotoxicity -- immunology
KW - Female
KW - Receptors, IgG -- genetics
KW - Breast Neoplasms -- immunology
KW - Breast Neoplasms -- genetics
KW - Breast Neoplasms -- drug therapy
KW - Breast Neoplasms -- mortality
KW - Breast Neoplasms -- pathology
KW - Breast Neoplasms -- metabolism
KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects
KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Anthracycline-free+neoadjuvant+therapy+induces+pathological+complete+responses+by+exploiting+immune+proficiency+in+HER2%2B+breast+cancer+patients.&rft.au=Miolo%2C+Gianmaria%3BMuraro%2C+Elena%3BMartorelli%2C+Debora%3BLombardi%2C+Davide%3BScalone%2C+Simona%3BSpazzapan%2C+Simon%3BMassarut%2C+Samuele%3BPerin%2C+Tiziana%3BViel%2C+Elda%3BComaro%2C+Elisa%3BTalamini%2C+Renato%3BBidoli%2C+Ettore%3BTurchet%2C+Elisa%3BCrivellari%2C+Diana%3BDolcetti%2C+Riccardo&rft.aulast=Miolo&rft.aufirst=Gianmaria&rft.date=2014-12-15&rft.volume=14&rft.issue=&rft.spage=954&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/10.1186%2F1471-2407-14-954
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-08-21
N1 - Date created - 2014-12-23
N1 - Date revised - 2017-01-14
N1 - Genetic sequence - NCT02307227; ClinicalTrials.gov
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1186/1471-2407-14-954
ER -
TY - JOUR
T1 - Harnessing the fcμ receptor for potent and selective cytotoxic therapy of chronic lymphocytic leukemia.
AN - 1637567101; 25344228
AB - Chronic lymphocytic leukemia (CLL) is a B-cell malignancy in need of new, effective, and safe therapies. The recently identified IgM receptor FcμR is overexpressed on malignant B cells in CLL and mediates the rapid internalization and lysosomal shuttling of IgM via its Fc fragment (Fcμ). To exploit this internalization and trafficking pathway for targeted drug delivery, we engineered an IgM-derived protein scaffold (Fcμ) and linked it with the cytotoxic agent monomethylauristatin F. This Fcμ-drug conjugate was selectively toxic for FcμR-expressing cell lines in vitro and for CLL cells but not autologous normal T cells ex vivo. Notably, the cytotoxic activity of the Fcμ-drug conjugate was maintained in CLL cells carrying a 17p deletion, which predicts resistance to standard chemotherapy. Next, we tested the possible therapeutic application of the Fcμ-drug conjugate in immunodeficient NOD/SCID/IL-2Rγ(null) (NSG) mice engrafted with peripheral blood cells from patients with leukemia. Three intravenous injections of the Fcμ-drug conjugate over a 10-day period were well tolerated and selectively killed the human CLL cells but not the coengrafted autologous human T cells. In summary, we developed a novel strategy for targeted cytotoxic therapy of CLL based on the unique properties of FcμR. FcμR-targeted drug delivery showed potent and specific therapeutic activity in CLL, thus providing proof of concept for FcμR as a valuable therapeutic target in CLL and for IgM-based antibody-drug conjugates as a new targeting platform.
©2014 American Association for Cancer Research.
JF - Cancer research
AU - Vire, Bérengère
AU - Skarzynski, Martin
AU - Thomas, Joshua D
AU - Nelson, Christopher G
AU - David, Alexandre
AU - Aue, Georg
AU - Burke, Terrence R
AU - Rader, Christoph
AU - Wiestner, Adrian
AD - Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland. ; Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute, NIH, Frederick, Maryland. ; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland. ; Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, Florida. Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida. wiestnera@mail.nih.gov crader@scripps.edu. ; Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland. wiestnera@mail.nih.gov crader@scripps.edu.
Y1 - 2014/12/15/
PY - 2014
DA - 2014 Dec 15
SP - 7510
EP - 7520
VL - 74
IS - 24
KW - Immunoglobulin M
KW - 0
KW - Receptors, Fc
KW - immunoglobulin M receptor
KW - Index Medicus
KW - Drug Delivery Systems
KW - Animals
KW - Peripheral Blood Stem Cell Transplantation
KW - Humans
KW - Apoptosis -- immunology
KW - Xenograft Model Antitumor Assays
KW - Mice
KW - Cell- and Tissue-Based Therapy
KW - B-Lymphocytes -- immunology
KW - Receptors, Fc -- immunology
KW - Receptors, Fc -- therapeutic use
KW - Leukemia, Lymphocytic, Chronic, B-Cell -- immunology
KW - Immunoglobulin M -- immunology
KW - Immunoglobulin M -- genetics
KW - Leukemia, Lymphocytic, Chronic, B-Cell -- pathology
KW - Cytotoxicity, Immunologic -- genetics
KW - Leukemia, Lymphocytic, Chronic, B-Cell -- therapy
KW - Receptors, Fc -- genetics
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1637567101?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Harnessing+the+fc%CE%BC+receptor+for+potent+and+selective+cytotoxic+therapy+of+chronic+lymphocytic+leukemia.&rft.au=Vire%2C+B%C3%A9reng%C3%A8re%3BSkarzynski%2C+Martin%3BThomas%2C+Joshua+D%3BNelson%2C+Christopher+G%3BDavid%2C+Alexandre%3BAue%2C+Georg%3BBurke%2C+Terrence+R%3BRader%2C+Christoph%3BWiestner%2C+Adrian&rft.aulast=Vire&rft.aufirst=B%C3%A9reng%C3%A8re&rft.date=2014-12-15&rft.volume=74&rft.issue=24&rft.spage=7510&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-14-2030
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-10
N1 - Date created - 2014-12-16
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Nat Biotechnol. 2012 Jul;30(7):631-7 [22781692]
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Clin Cancer Res. 2012 Nov 1;18(21):5845-9 [22962441]
Blood. 2012 Dec 6;120(24):4684-91 [22875912]
Leukemia. 2013 Dec;27(12):2311-21 [23619564]
Methods. 2014 Jan 1;65(1):133-8 [23756202]
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Cancer Res. 1997 Nov 1;57(21):4940-7 [9354461]
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J Immunol. 1998 Oct 15;161(8):4091-7 [9780180]
Leukemia. 1999 Oct;13(10):1501-5 [10516749]
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Nat Biotechnol. 2008 Aug;26(8):925-32 [18641636]
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Blood. 2008 Nov 15;112(10):4213-9 [18708628]
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Curr Opin Chem Biol. 2009 Jun;13(3):235-44 [19414278]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1158/0008-5472.CAN-14-2030
ER -
TY - JOUR
T1 - A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides.
AN - 1629962185; 25448441
AB - The currently fielded pre-hospital therapeutic regimen for the treatment of organophosphorus (OP) poisoning in the United States (U.S.) is the administration of atropine in combination with an oxime antidote (2-PAM Cl) to reactivate inhibited acetylcholinesterase (AChE). Depending on clinical symptoms, an anticonvulsant, e.g., diazepam, may also be administered. Unfortunately, 2-PAM Cl does not offer sufficient protection across the range of OP threat agents, and there is some question as to whether it is the most effective oxime compound available. The objective of the present study is to identify an oxime antidote, under standardized and comparable conditions, that offers protection at the FDA approved human equivalent dose (HED) of 2-PAM Cl against tabun (GA), sarin (GB), soman (GD), cyclosarin (GF), and VX, and the pesticides paraoxon, chlorpyrifos oxon, and phorate oxon. Male Hartley guinea pigs were subcutaneously challenged with a lethal level of OP and treated at approximately 1 min post challenge with atropine followed by equimolar oxime therapy (2-PAM Cl, HI-6 DMS, obidoxime Cl₂, TMB-4, MMB4-DMS, HLö-7 DMS, MINA, and RS194B) or therapeutic-index (TI) level therapy (HI-6 DMS, MMB4-DMS, MINA, and RS194B). Clinical signs of toxicity were observed for 24 h post challenge and blood cholinesterase [AChE and butyrylcholinesterase (BChE)] activity was analyzed utilizing a modified Ellman's method. When the oxime is standardized against the HED of 2-PAM Cl for guinea pigs, the evidence from clinical observations, lethality, quality of life (QOL) scores, and cholinesterase reactivation rates across all OPs indicated that MMB4 DMS and HLö-7 DMS were the two most consistently efficacious oximes. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
JF - Toxicology and applied pharmacology
AU - Wilhelm, Christina M
AU - Snider, Thomas H
AU - Babin, Michael C
AU - Jett, David A
AU - Platoff, Gennady E
AU - Yeung, David T
AD - Battelle, 505 King Avenue, JM-7, Columbus, OH 43201-2693, USA. Electronic address: wilhelmc@battelle.org. ; Battelle, 505 King Avenue, JM-7, Columbus, OH 43201-2693, USA. Electronic address: snidert@battelle.org. ; Battelle, 505 King Avenue, JM-7, Columbus, OH 43201-2693, USA. Electronic address: babinm@battelle.org. ; National Institutes of Health/National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. Electronic address: jettd@ninds.nih.gov. ; National Institutes of Health/National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Electronic address: platoffg@niaid.nih.gov. ; National Institutes of Health/National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. Electronic address: dy70v@nih.gov.
Y1 - 2014/12/15/
PY - 2014
DA - 2014 Dec 15
SP - 254
EP - 265
VL - 281
IS - 3
KW - Antidotes
KW - 0
KW - Chemical Warfare Agents
KW - Cholinesterase Inhibitors
KW - Cholinesterase Reactivators
KW - Muscarinic Antagonists
KW - Oximes
KW - Pesticides
KW - Pyridinium Compounds
KW - HLo 7
KW - 120103-35-7
KW - N,N'-monomethylenebis(pyridiniumaldoxime)
KW - 61444-84-6
KW - Atropine
KW - 7C0697DR9I
KW - Cholinesterases
KW - EC 3.1.1.8
KW - Index Medicus
KW - Guinea pig
KW - Intramuscular
KW - Efficacy
KW - Toxicity
KW - Oxime
KW - Pyridinium Compounds -- therapeutic use
KW - Drug Therapy, Combination -- adverse effects
KW - Animals
KW - Pyridinium Compounds -- administration & dosage
KW - Drug Administration Schedule
KW - Muscarinic Antagonists -- adverse effects
KW - Muscarinic Antagonists -- administration & dosage
KW - Cholinesterases -- blood
KW - Random Allocation
KW - Guinea Pigs
KW - Injections, Intramuscular
KW - Atropine -- administration & dosage
KW - Muscarinic Antagonists -- therapeutic use
KW - Atropine -- adverse effects
KW - Drug Monitoring
KW - Injections, Subcutaneous
KW - Pyridinium Compounds -- adverse effects
KW - Male
KW - Atropine -- therapeutic use
KW - Cholinesterase Inhibitors -- administration & dosage
KW - Antidotes -- administration & dosage
KW - Oximes -- administration & dosage
KW - Cholinesterase Inhibitors -- chemistry
KW - Oximes -- therapeutic use
KW - Antidotes -- therapeutic use
KW - Chemical Warfare Agents -- chemistry
KW - Cholinesterase Reactivators -- administration & dosage
KW - Chemical Warfare Agents -- toxicity
KW - Pesticides -- toxicity
KW - Organophosphate Poisoning -- physiopathology
KW - Organophosphate Poisoning -- drug therapy
KW - Pesticides -- antagonists & inhibitors
KW - Cholinesterase Inhibitors -- toxicity
KW - Organophosphate Poisoning -- blood
KW - Cholinesterase Reactivators -- therapeutic use
KW - Antidotes -- adverse effects
KW - Oximes -- adverse effects
KW - Cholinesterase Reactivators -- adverse effects
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=A+comprehensive+evaluation+of+the+efficacy+of+leading+oxime+therapies+in+guinea+pigs+exposed+to+organophosphorus+chemical+warfare+agents+or+pesticides.&rft.au=Wilhelm%2C+Christina+M%3BSnider%2C+Thomas+H%3BBabin%2C+Michael+C%3BJett%2C+David+A%3BPlatoff%2C+Gennady+E%3BYeung%2C+David+T&rft.aulast=Wilhelm&rft.aufirst=Christina&rft.date=2014-12-15&rft.volume=281&rft.issue=3&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2014.10.009
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-17
N1 - Date created - 2014-12-03
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
J Biol Chem. 2011 Jun 3;286(22):19422-30 [21464125]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.taap.2014.10.009
ER -
TY - JOUR
T1 - Mass spectrometric analysis of rat cerebrospinal fluid proteins following exposure to the neurotoxicant carbonyl sulfide.
AN - 1620587838; 25366400
AB - Using a proteomic-based approach we have investigated possible altered expression of a range of cerebral spinal fluid (CSF) proteins following exposure to the neurotoxicant carbonyl sulfide (COS). CSF is ideal for the investigation of markers of brain injury or disease since it is secreted from several central nervous system structures and changes in the CSF composition may reflect brain insult and many pathological processes.
Animals were placed in exposure chambers and were exposed to 0 ppm or 500 ppm COS for 1, 2 or 3 days, 6 h per day. After the last inhalation exposure, 50-70 μL CSF sample was obtained by lumbar puncture. CSF samples were analyzed by electrospray ionization mass spectrometry (ESI-MS) on either a Premier quadrupole time-of-flight (QTOF) or an Agilent 6340 ion trap and by matrix-assisted laser desorption/ionization (MALDI)-MS on a 4800 MALDI-TOF/TOF analyzer. The dynamic range of abundance of the identified proteins spanned over more than three orders of magnitude. The four most abundant proteins identified (albumin, cystatin C, serotransferrin, transthyretin) are major proteins that are present in both CSF and blood at high levels but the fifth most abundant protein identified (prostaglandin H2D isomerase) is the second most abundant protein in human CSF and is secreted and synthesized in the rat central nervous system. No significant differences were observed between COS-treated CSF samples and the control CSF samples because of blood contamination.
Quantitative MS protein analyses of rat CSF is limited by the low sample volumes that can practicably be obtained from rats and the low protein concentrations in rat CSF. Results of this work suggest a clear need for CSF collection that would minimize blood contamination. Published in 2014. This article is a U.S. Government work and is in the public domain in the USA. Published in 2014. This article is a U.S. Government work and is in the public domain in the USA.
JF - Rapid communications in mass spectrometry : RCM
AU - Lardinois, O
AU - Kirby, P J
AU - Morgan, D L
AU - Sills, R C
AU - Tomer, K B
AU - Deterding, L J
AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH/DHHS, 111 T.W. Alexander Drive, PO Box 12233, Research Triangle Park, NC, 27709, USA.
Y1 - 2014/12/15/
PY - 2014
DA - 2014 Dec 15
SP - 2531
EP - 2538
VL - 28
IS - 23
KW - Cerebrospinal Fluid Proteins
KW - 0
KW - Proteome
KW - Sulfur Oxides
KW - carbonyl sulfide
KW - 871UI0ET21
KW - Index Medicus
KW - Rats
KW - Animals
KW - Inhalation Exposure
KW - Proteomics
KW - Principal Component Analysis
KW - Male
KW - Cerebrospinal Fluid Proteins -- analysis
KW - Neurotoxicity Syndromes -- etiology
KW - Sulfur Oxides -- toxicity
KW - Proteome -- analysis
KW - Proteome -- chemistry
KW - Neurotoxicity Syndromes -- cerebrospinal fluid
KW - Spectrometry, Mass, Electrospray Ionization -- methods
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-06-17
N1 - Date created - 2014-11-04
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Electrophoresis. 2012 Dec;33(24):3617-30 [23160951]
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Erratum In:
Rapid Commun Mass Spectrom. 2015 Apr 30;29(8):782 [26406493]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1002/rcm.7046
ER -
TY - JOUR
T1 - An integrative approach to understanding bird origins
AN - 1832582803; 722341-1
AB - Recent discoveries of spectacular dinosaur fossils overwhelmingly support the hypothesis that birds are descended from maniraptoran theropod dinosaurs, and furthermore, demonstrate that distinctive bird characteristics such as feathers, flight, endothermic physiology, unique strategies for reproduction and growth, and a novel pulmonary system originated among Mesozoic terrestrial dinosaurs. The transition from ground-living to flight-capable theropod dinosaurs now probably represents one of the best-documented major evolutionary transitions in life history. Recent studies in developmental biology and other disciplines provide additional insights into how bird characteristics originated and evolved. The iconic features of extant birds for the most part evolved in a gradual and stepwise fashion throughout archosaur evolution. However, new data also highlight occasional bursts of morphological novelty at certain stages particularly close to the origin of birds and an unavoidable complex, mosaic evolutionary distribution of major bird characteristics on the theropod tree. Research into bird origins provides a premier example of how paleontological and neontological data can interact to reveal the complexity of major innovations, to answer key evolutionary questions, and to lead to new research directions. A better understanding of bird origins requires multifaceted and integrative approaches, yet fossils necessarily provide the final test of any evolutionary model.
JF - Science
AU - Xu, Xing
AU - Zhou, Zhonghe
AU - Dudley, Robert
AU - Mackem, Susan
AU - Chuong, Cheng-Ming
AU - Erickson, Gregory M
AU - Varricchio, David J
Y1 - 2014/12/12/
PY - 2014
DA - 2014 Dec 12
SP - 1341
PB - American Association for the Advancement of Science, Washington, DC
VL - 346
IS - 6215
SN - 0036-8075, 0036-8075
KW - Archaeornithes
KW - Diapsida
KW - Chordata
KW - phylogeny
KW - biologic evolution
KW - feathers
KW - Reptilia
KW - Aves
KW - Archosauria
KW - Theropoda
KW - Saurischia
KW - dinosaurs
KW - Vertebrata
KW - Tetrapoda
KW - Archaeopteryx
KW - 11:Vertebrate paleontology
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L2 - http://www.sciencemag.org/magazine
LA - English
DB - GeoRef
N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef.
N1 - PubXState - DC
N1 - Document feature - illus.
N1 - SuppNotes - Full text available only online
N1 - Last updated - 2017-01-24
N1 - CODEN - SCIEAS
N1 - SubjectsTermNotLitGenreText - Archaeopteryx; Archaeornithes; Archosauria; Aves; biologic evolution; Chordata; Diapsida; dinosaurs; feathers; phylogeny; Reptilia; Saurischia; Tetrapoda; Theropoda; Vertebrata
DO - http://dx.doi.org/10.1126/science.1253293
ER -
TY - JOUR
T1 - Phase I study of the halichondrin B analogue eribulin mesylate in combination with cisplatin in advanced solid tumors.
AN - 1635004048; 25349975
AB - Eribulin mesylate is a synthetic macrocyclic ketone analogue of Halichondrin B that has demonstrated high antitumor activity in preclinical and clinical settings. This phase I study aimed to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and pharmacokinetics in combination with cisplatin (CP) in patients with advanced solid tumours.
Thirty-six patients with advanced solid tumours received eribulin mesylate 0.7-1.4 mg m(-2) and CP 60-75 mg m(-2). Eribulin mesylate was administered on days 1, 8, and 15 in combination with CP day 1 every 28-day cycle. The protocol was amended after dose level 4 (eribulin mesylate 1.4 mg m(-2), CP 60 mg m(-2)) when it was not feasible to administer eribulin mesylate on day 15 because of neutropenia; the treatment schedule was changed to eribulin mesylate on days 1 and 8 and CP on day 1 every 21 days. On the 28-day schedule, three patients had DLT during the first cycle: grade (G) 4 febrile neutropenia (1.0 mg m(-2), 60 mg m(-2)); G 3 anorexia/fatigue/hypokalemia (1.2 mg m(-2), 60 mg m(-2)); and G 3 stomatitis/nausea/vomiting/fatigue (1.4 mg m(-2), 60 mg m(-2)). On the 21-day schedule, three patients had DLT during the first cycle: G 3 hypokalemia/hyponatremia (1.4 mg m(-2), 60 mg m(-2)); G 4 mucositis (1.4 mg m(-2), 60 mg m(-2)); and G 3 hypokalemia (1.2 mg m(-2), 75 mg m(-2)). The MTD and recommended phase II dose was determined as eribulin mesylate 1.2 mg m(-2) (days 1, 8) and CP 75 mg m(-2) (day 1), on a 21-day cycle. Two patients had unconfirmed partial responses (PR) (pancreatic and breast cancers) and two had PR (oesophageal and bladder cancers).
On the 21-day cycle, eribulin mesylate 1.2 mg m(-2), administered on days 1 and 8, in combination with CP 75 mg m(-2), administered on day 1 is well tolerated and showed preliminary anticancer activity.
JF - British journal of cancer
AU - Koczywas, M
AU - Frankel, P H
AU - Synold, T W
AU - Lenz, H-J
AU - Mortimer, J E
AU - El-Khoueiry, A B
AU - Gandara, D R
AU - Cristea, M C
AU - Chung, V M
AU - Lim, D
AU - Reckamp, K L
AU - Lau, D H
AU - Doyle, L A
AU - Ruel, C
AU - Carroll, M I
AU - Newman, E M
AD - Department of Medical Oncology, City of Hope, Duarte, CA, USA. ; Department of Information Sciences, City of Hope, Duarte, CA, USA. ; Department of Molecular Pharmacology, City of Hope National Medical Center, Duarte, CA, USA. ; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. ; Medical Center, UC Davis Comprehensive Cancer Center, Sacramento, CA, USA. ; Investigational Drug Research, National Cancer Institute, Rockville, MD, USA. ; Department of Research-RN, City of Hope, Duarte, CA, USA.
Y1 - 2014/12/09/
PY - 2014
DA - 2014 Dec 09
SP - 2268
EP - 2274
VL - 111
IS - 12
KW - Ethers, Cyclic
KW - 0
KW - Furans
KW - Ketones
KW - Macrolides
KW - halichondrin B
KW - 103614-76-2
KW - eribulin
KW - LR24G6354G
KW - Cisplatin
KW - Q20Q21Q62J
KW - Index Medicus
KW - Furans -- administration & dosage
KW - Young Adult
KW - Ketones -- administration & dosage
KW - Ketones -- adverse effects
KW - Humans
KW - Furans -- adverse effects
KW - Adult
KW - Aged
KW - Middle Aged
KW - Cisplatin -- adverse effects
KW - Cisplatin -- administration & dosage
KW - Neoplasms -- drug therapy
KW - Macrolides -- therapeutic use
KW - Ethers, Cyclic -- therapeutic use
KW - Ethers, Cyclic -- adverse effects
KW - Ethers, Cyclic -- administration & dosage
KW - Macrolides -- administration & dosage
KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects
KW - Macrolides -- adverse effects
KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-04-16
N1 - Date created - 2014-12-10
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1038/bjc.2014.554
ER -
TY - CPAPER
T1 - EHD proteins coordinate membrane reorganization and fusion to initiate early steps of ciliogenesis
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638908; 6328208
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Insinna, C
AU - Lu, Q.
AU - Ott, C
AU - Baxa, U
AU - Lopes, S
AU - Lippincott- Schwartz, J
AU - Caplan, S
AU - Jackson, P
AU - Westlake, C
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Membrane fusion
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L2 - http://www.ascb.org/2014meeting/program/files/assets/common/downloads/2014%20ASCB%20PROGRAM.pdf
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Autophagy/mitophagy and neurodegenerative diseases
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638898; 6327999
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Youle, Richard
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Neurodegenerative diseases
KW - Phagocytosis
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L2 - http://www.ascb.org/2014meeting/program/files/assets/common/downloads/2014%20ASCB%20PROGRAM.pdf
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Neurogenetic insights into organelle biogenesis
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638875; 6328087
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Blackstone, Craig
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Biogenesis
KW - Neurogenetics
KW - Organelles
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L2 - http://www.ascb.org/2014meeting/program/files/assets/common/downloads/2014%20ASCB%20PROGRAM.pdf
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Light Sheet Fluorescence Microscopy (LSFM): Imaging Faster and Gentler
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638869; 6327982
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Kumar, Abhishek
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Imaging techniques
KW - Fluorescence microscopy
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L2 - http://www.ascb.org/2014meeting/program/files/assets/common/downloads/2014%20ASCB%20PROGRAM.pdf
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - A novel actin-adhesion structure involved in nuclear positioning requires the formin FMN2
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638805; 6327898
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Skau, C
AU - Waterman, C
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Cytology
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T1 - PINK1 is a ubiquitin kinase
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638763; 6328137
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Kane, L
AU - Lazarou, M
AU - Fogel, A
AU - Li, Y.
AU - Yamano, K
AU - Sarraf, S
AU - Banerjee, S
AU - Youle, R
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - PTEN-induced putative kinase
KW - Ubiquitin
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T1 - Transcriptional regulation by noncoding RNA dissected with single-molecule observation in living cells
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638711; 6327809
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Larson, Daniel
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - RNA
KW - Gene regulation
KW - Transcription
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T1 - Organelle biogenesis: insights from the hereditary spastic paraplegias
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638686; 6328069
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Blackstone, Craig
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Hereditary spastic paraplegia
KW - Biogenesis
KW - Organelles
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T1 - Quality control of GPI-anchored proteins in the secretory pathway
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638628; 6328201
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Satpute-Krishnan, P
AU - Lippincott-Schwartz, J
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Quality control
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T1 - The budding yeast polo kinase, Cdc5, regulates domain-specific expansion of the nuclear envelope
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638558; 6328032
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Cohen-Fix, O
AU - Walters, A
AU - May, C
AU - Dauster, E
AU - Cinquin, B
AU - Smith, E
AU - Larabell, C
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Nuclear membranes
KW - Budding
KW - Saccharomyces cerevisiae
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N1 - Date revised - 2014-12-31
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T1 - Finding treatments for mitochondrial diseases by stimulating quality control pathways
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638518; 6328072
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Youle, Richard
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Quality control
KW - Disease control
KW - Mitochondria
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T1 - Theory-experiment interface in biology
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638503; 6327827
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Lippincott-Schwartz, Jennifer
AU - Phillips, Rob
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Cytology
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N1 - Date revised - 2014-12-31
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T1 - Structural studies into the mechanistic origin of microtubule dynamic instability
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638458; 6327966
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Alushin, G
AU - Lander, G
AU - Kellogg, E
AU - Zhang, R
AU - Baker, D
AU - Nogales, E
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Microtubules
KW - Instability
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N1 - Date revised - 2014-12-31
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T1 - Two step model for centriole disengagement
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647638434; 6327796
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Loncerak, Jadranka
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Centrioles
KW - Models
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N1 - Date revised - 2014-12-31
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T1 - Nuclear keratin and the regulation of gene expression in tumor epithelial cells
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635697; 6327739
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Coulombe, Pierre
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Gene expression
KW - Epithelial cells
KW - Keratin
KW - Tumors
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N1 - Date revised - 2014-12-31
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T1 - Novel spectral imaging and analysis to unravel the organelle interactome
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635688; 6328022
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Valm, A
AU - Cohen, S
AU - Legant, W
AU - Davidson, M
AU - Betzig, E
AU - Lippincott-Schwartz, J
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Organelles
KW - Imaging techniques
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DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
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TY - CPAPER
T1 - Damage control: how PINK1 and Parkin survey mitochondrial fidelity and respond with selective autophagy
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635638; 6328078
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Youle, R
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - parkin protein
KW - Fidelity
KW - PTEN-induced putative kinase
KW - Mitochondria
KW - Phagocytosis
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
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TY - CPAPER
T1 - Current events at NIGMS
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635629; 6327719
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Lorsch, Jon
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Cytology
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T1 - Novel ER shaping proteins Pex30 and Pex31 are involved in pre-peroxisome vesicle biogenesis
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635599; 6328135
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Joshi, A
AU - Prinz, W
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Biogenesis
KW - Vesicles
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T1 - Monitoring of Circulating Tumor DNA As Minimal Residual Disease in Diffuse Large B-Cell Lymphoma
T2 - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AN - 1647635567; 6327559
JF - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AU - Roschewski, Mark
AU - Dunleavy, Kieron
AU - Fadle, Natalie
AU - Regitz, Evi
AU - Roth, Patrick
AU - Monoranu, Camelia-Maria
AU - Buslei, Rolf
AU - Bohle, Rainer
AU - Kim, Yoo-Jin
AU - Preuss, Klaus-Dieter
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - minimal residual disease
KW - B-cell lymphoma
KW - Tumors
KW - Lymphoma
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T1 - Dynamic modulation of cortical actin at the immunological synapse controls cytotoxic granule secretion
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635513; 6327730
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Ritter, Alex
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Granules
KW - Cytotoxicity
KW - Cortex
KW - Secretion
KW - Actin
KW - Immunological synapses
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T1 - Lipid exhange at contact sites
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635454; 6327749
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Prinz, Will
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Lipids
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T1 - Mechanism of protein incorporation into envelop of budding HIV particle
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635424; 6327936
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Sengupta, P
AU - van Engelenburg, S.
AU - Johnson, M
AU - Lippincott-Schwartz, J
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Human immunodeficiency virus
KW - Particulates
KW - Budding
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T1 - Coatopathies: genetic disorders of protein coats
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635413; 6328068
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Bonifacino, Juan
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Proteins
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T1 - Using Quantitative and Superresolution Microscopy to Visualize the Dynamic, 3D Molecular Clutch That Drives Cell Migration
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635322; 6327981
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Waterman, Clare
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Clutch
KW - Microscopy
KW - Cell migration
KW - Migration
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T1 - Microtubules and membrane-to-mitochondria connections: relationships between cell biology and targeted chemotherapeutics
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635321; 6327685
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Sackett, Dan
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Microtubules
KW - Cytology
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T1 - Targeting the metabolic basis of Fumarate Hydratase-deficient kidney cancer
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635290; 6328070
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Linehan, W
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Kidneys
KW - Cancer
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N1 - Date revised - 2014-12-31
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T1 - Technology development and biological discovery
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635237; 6327877
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Lippincott-Schwartz, Jennifer
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Technology
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T1 - What's the 'Skinny' on Microbiome? Interplay of Immune Cells, Microbes, and Skin Barrier in Health and Disease
T2 - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AN - 1647635227; 6327339
JF - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AU - Segre, Julie
AU - Kong, Heidi
AU - Candotti, Fabio
AU - Holland, Steven
AU - Freeman, Alexandra
AU - Oh, Julia
AU - Sokolic, Robert
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Barriers
KW - Skin
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T1 - Functional specificity of integrin-based adhesions in cell function is defined by actin nucleators
T2 - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AN - 1647635222; 6327842
JF - 2014 American Society for Cell Biology and International Federation for Cell Biology Meeting (2014 ASCB/IFCB)
AU - Waterman, C
AU - Case, L
AU - Swaminathan, V
AU - Skau, C
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Specificity
KW - Actin
KW - Adhesion
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T1 - Treatment: Current Paradigms and Novel Targeted Approaches
T2 - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AN - 1647635150; 6327308
JF - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AU - Dunleavy, Kieron
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Hematology
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L2 - https://ash.confex.com/ash/2014/webprogram/start.html
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - B-Cell Receptor Pathway Inhibition as Therapy for Chronic Lymphocytic Leukemia and Lymphoplasmacytic Lymphoma
T2 - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AN - 1647634863; 6327362
JF - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AU - Wiestner, Adrian
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - B-cell receptor
KW - Therapy
KW - Chronic lymphatic leukemia
KW - Lymphoma
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L2 - https://ash.confex.com/ash/2014/webprogram/start.html
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Acquired Aplastic Anemia: New Genetics, New Genomics
T2 - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AN - 1647633728; 6327371
JF - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AU - Young, Neal
AU - Dumitriu, Bogdan
AU - Ogawa, Seishi
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Genetics
KW - Anemia
KW - genomics
KW - Aplastic anemia
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L2 - https://ash.confex.com/ash/2014/webprogram/start.html
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts
T2 - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AN - 1647633486; 6327465
JF - 56th Annual Meeting of the American Society of Hematology (ASH 2014)
AU - Lee, Y
AU - Byrnes, Colleen
AU - de Vasconcellos, Jaira
AU - Kaushal, Megha
AU - Rabel, Antoinette
AU - Tumburu, Laxminath
AU - Allwardt, Joshua
AU - Miller, Jeffery
Y1 - 2014/12/06/
PY - 2014
DA - 2014 Dec 06
KW - Erythroblasts
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L2 - https://ash.confex.com/ash/2014/webprogram/start.html
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - JOUR
T1 - p53 mutations and inflammation-associated cancer are linked through TNF signaling.
AN - 1634277250; 25479634
AB - In this issue, Di Minin et al. (2014) link mutant p53 and chronic inflammation to tumorigenic progression via TNF signaling. Mutp53 interacts with the tumor suppressor DAB2IP in the cytoplasm, and induces a TNF-dependent transcriptional profile via NF-kB and JNK.
Copyright © 2014 Elsevier Inc. All rights reserved.
JF - Molecular cell
AU - Cooks, Tomer
AU - Harris, Curtis C
AD - Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, 20892-4258, USA. Electronic address: tomer.cooks@nih.gov. ; Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, 20892-4258, USA.
Y1 - 2014/12/04/
PY - 2014
DA - 2014 Dec 04
SP - 611
EP - 612
VL - 56
IS - 5
KW - Tumor Necrosis Factor-alpha
KW - 0
KW - Tumor Suppressor Protein p53
KW - ras GTPase-Activating Proteins
KW - Index Medicus
KW - Animals
KW - Humans
KW - Female
KW - ras GTPase-Activating Proteins -- metabolism
KW - Breast Neoplasms -- genetics
KW - Breast Neoplasms -- pathology
KW - Tumor Suppressor Protein p53 -- genetics
KW - Tumor Necrosis Factor-alpha -- metabolism
KW - Tumor Suppressor Protein p53 -- metabolism
KW - Signal Transduction
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-05
N1 - Date created - 2014-12-06
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Comment On:
Mol Cell. 2014 Dec 4;56(5):617-29 [25454946]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.molcel.2014.11.018
ER -
TY - JOUR
T1 - PET/CT imaging correlates with treatment outcome in patients with multidrug-resistant tuberculosis
AN - 1709170903; PQ0001773266
AB - Definitive clinical trials of new chemotherapies for treating tuberculosis (TB) require following subjects until at least 6 months after treatment discontinuation to assess for durable cure, making these trials expensive and lengthy. Surrogate endpoints relating to treatment failure and relapse are currently limited to sputum microbiology, which has limited sensitivity and specificity. We prospectively assessed radiographic changes using 2-deoxy-2-[ super(18)F]-fluoro-Dglucose (FDG) positron emission tomography/computed tomography (PET/CT) at 2 and 6 months (CT only) in a cohort of subjects with multidrug-resistant TB, who were treated with second-line TB therapy for 2 years and then followed for an additional 6 months. CT scans were read semiquantitatively by radiologists and were computationally evaluated using custom software to provide volumetric assessment of TB-associated abnormalities. CT scans at 6 months (but not 2 months) assessed by radiologist readers were predictive of outcomes, and changes in computed abnormal volumes were predictive of drug response at both time points. Quantitative changes in FDG uptake 2 months after starting treatment were associated with long- term outcomes. In this cohort, some radiologic markers were more sensitive than conventional sputum microbiology in distinguishing successful from unsuccessful treatment. These results support the potential of imaging scans as possible surrogate endpoints in clinical trials of new TB drug regimens. Larger cohorts confirming these results are needed.
JF - Science Translational Medicine
AU - Chen, Ray Y
AU - Dodd, Lori E
AU - Lee, Myungsun
AU - Paripati, Praveen
AU - Hammoud, Dima A
AU - Mountz, James M
AU - Jeon, Doosoo
AU - Zia, Nadeem
AU - Zahiri, Homeira
AU - Coleman, M Teresa
AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA
Y1 - 2014/12/03/
PY - 2014
DA - 2014 Dec 03
PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 United States
VL - 6
IS - 265
SN - 1946-6234, 1946-6234
KW - Microbiology Abstracts B: Bacteriology
KW - Translation
KW - Mycobacterium
KW - Drug resistance
KW - Chemotherapy
KW - Clinical trials
KW - Computer programs
KW - software
KW - Computed tomography
KW - Positron emission tomography
KW - Tuberculosis
KW - Sputum
KW - Drugs
KW - J 02400:Human Diseases
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-09-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Computer programs; Translation; software; Chemotherapy; Drug resistance; Computed tomography; Positron emission tomography; Tuberculosis; Sputum; Drugs; Clinical trials; Mycobacterium
DO - http://dx.doi.org/10.1126/scitranslmed.3009501
ER -
TY - JOUR
T1 - Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea.
AN - 1629955572; 25406324
AB - TET/JBP enzymes oxidize 5-methylpyrimidines in DNA. In mammals, the oxidized methylcytosines (oxi-mCs) function as epigenetic marks and likely intermediates in DNA demethylation. Here we present a method based on diglucosylation of 5-hydroxymethylcytosine (5hmC) to simultaneously map 5hmC, 5-formylcytosine, and 5-carboxylcytosine at near-base-pair resolution. We have used the method to map the distribution of oxi-mC across the genome of Coprinopsis cinerea, a basidiomycete that encodes 47 TET/JBP paralogs in a previously unidentified class of DNA transposons. Like 5-methylcytosine residues from which they are derived, oxi-mC modifications are enriched at centromeres, TET/JBP transposons, and multicopy paralogous genes that are not expressed, but rarely mark genes whose expression changes between two developmental stages. Our study provides evidence for the emergence of an epigenetic regulatory system through recruitment of selfish elements in a eukaryotic lineage, and describes a method to map all three different species of oxi-mCs simultaneously.
JF - Proceedings of the National Academy of Sciences of the United States of America
AU - Chavez, Lukas
AU - Huang, Yun
AU - Luong, Khai
AU - Agarwal, Suneet
AU - Iyer, Lakshminarayan M
AU - Pastor, William A
AU - Hench, Virginia K
AU - Frazier-Bowers, Sylvia A
AU - Korol, Evgenia
AU - Liu, Shuo
AU - Tahiliani, Mamta
AU - Wang, Yinsheng
AU - Clark, Tyson A
AU - Korlach, Jonas
AU - Pukkila, Patricia J
AU - Aravind, L
AU - Rao, Anjana
AD - Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037; ; Pacific Biosciences, Menlo Park, CA 94025; ; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115; ; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; ; Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; ; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; ; Skirball Institute, NYU Langone Medical Center, New York University, New York, NY 10016; ; Environmental Toxicology Graduate Program and Department of Chemistry, University of California, Riverside, CA 92521; and. ; Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093 arao@liai.org.
Y1 - 2014/12/02/
PY - 2014
DA - 2014 Dec 02
SP - E5149
EP - E5158
VL - 111
IS - 48
KW - DNA Transposable Elements
KW - 0
KW - Fungal Proteins
KW - 5-Methylcytosine
KW - 6R795CQT4H
KW - Dioxygenases
KW - EC 1.13.11.-
KW - Index Medicus
KW - SMRT-seq
KW - 5fC
KW - 5mC
KW - 5caC
KW - TET
KW - Gene Expression Regulation, Fungal
KW - Genome, Fungal -- genetics
KW - Hyphae -- growth & development
KW - HEK293 Cells
KW - Humans
KW - Spores, Fungal -- growth & development
KW - Sequence Analysis -- methods
KW - Hyphae -- genetics
KW - Chromosomes, Fungal -- genetics
KW - Oxidation-Reduction
KW - DNA Methylation
KW - Spores, Fungal -- metabolism
KW - DNA Transposable Elements -- genetics
KW - Gene Expression Regulation, Developmental
KW - Hyphae -- metabolism
KW - Fungal Proteins -- metabolism
KW - Dioxygenases -- genetics
KW - 5-Methylcytosine -- metabolism
KW - Basidiomycota -- growth & development
KW - Basidiomycota -- genetics
KW - Fungal Proteins -- genetics
KW - Dioxygenases -- metabolism
KW - Basidiomycota -- metabolism
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Simultaneous+sequencing+of+oxidized+methylcytosines+produced+by+TET%2FJBP+dioxygenases+in+Coprinopsis+cinerea.&rft.au=Chavez%2C+Lukas%3BHuang%2C+Yun%3BLuong%2C+Khai%3BAgarwal%2C+Suneet%3BIyer%2C+Lakshminarayan+M%3BPastor%2C+William+A%3BHench%2C+Virginia+K%3BFrazier-Bowers%2C+Sylvia+A%3BKorol%2C+Evgenia%3BLiu%2C+Shuo%3BTahiliani%2C+Mamta%3BWang%2C+Yinsheng%3BClark%2C+Tyson+A%3BKorlach%2C+Jonas%3BPukkila%2C+Patricia+J%3BAravind%2C+L%3BRao%2C+Anjana&rft.aulast=Chavez&rft.aufirst=Lukas&rft.date=2014-12-02&rft.volume=111&rft.issue=48&rft.spage=E5149&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.1419513111
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-04-28
N1 - Date created - 2014-12-03
N1 - Date revised - 2017-01-14
N1 - Genetic sequence - SRP041464; SRA; GSE46965; GEO
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1073/pnas.1419513111
ER -
TY - JOUR
T1 - Spatiotemporal relationships among Late Pennsylvanian plant assemblages; palynological evidence from the Markley Formation, West Texas, U.S.A.
AN - 1832611679; 716628-2
AB - The Pennsylvanian lowlands of western Pangea are best known for their diverse wetland floras of arborescent and herbaceous ferns, and arborescent horsetails and clubmosses. In apparent juxtaposition, a very different kind of flora, dominated by a xerophilous assemblage of conifers, taeniopterids and peltasperms, is occasionally glimpsed. Once believed to represent upland or extrabasinal floras from well-drained portions of the landscape, these dryland floras more recently have been interpreted as lowland assemblages growing during drier phases of glacial/interglacial cycles. Whether Pennsylvanian dryland and wetland floras were separated spatially or temporally remains an unsettled question, due in large part to taphonomic bias toward preservation of wetland plants. Previous paleobotanical and sedimentological analysis of the Markley Formation of latest Pennsylvanian (Gzhelian) age, from north central Texas, U.S.A, indicates close correlation between lithofacies and distinct dryland and wetland megaflora assemblages. Here we present a detailed analysis one of those localities, a section unusual in containing abundant palynomorphs, from the lower Markley Formation. Paleobotanical, palynological and lithological data from a section thought to represent a single interglacial/glacial phase are integrated and analyzed to create a complex picture of an evolving landscape. Megafloral data from throughout the Markley Formation show that conifer-dominated dryland floras occur exclusively in highly leached kaolinite beds, likely eroded from underlying soils, whereas a mosaic of wetland floras occupy histosols, ultisols, and fluvial overbank deposits. Palynological data largely conform to this pattern but reveal a more complex picture. An assemblage of mixed wetland and dryland palynofloral taxa is interpolated between a dryland assemblage and an overlying histosol containing wetland taxa. In this section, as well as elsewhere in the Markley Formation, kaolinite and overlying organic beds appear to have formed as a single genetic unit, with the kaolinite forming an impermeable aquiclude upon which a poorly drained wetland subsequently formed. Within a single inferred glacial/interglacial cycle, lithological data indicate significant fluctuations in water availability tracked by changes in palynofloral and megafloral taxa. Palynology reveals that elements of the dryland floras appear at low abundance even within wetland deposits. The combined data indicate a complex pattern of succession and suggest a mosaic of dryland and wetland plant communities in the Late Pennsylvanian. Our data alone cannot show whether dryland and wetland assemblages succeed one another temporally, or coexisted on the landscape. However, the combined evidence suggests relatively close spatial proximity within a fragmenting and increasingly arid environment. Abstract Copyright (2014) Elsevier, B.V.
JF - Review of Palaeobotany and Palynology
AU - Looy, Cindy V
AU - Hotton, Carol L
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 10
EP - 27
PB - Elsevier, Amsterdam
VL - 211
SN - 0034-6667, 0034-6667
KW - silicates
KW - Spermatophyta
KW - terrestrial environment
KW - Cisuralian
KW - Pennsylvanian
KW - siliciclastics
KW - Lower Permian
KW - climate change
KW - sedimentary rocks
KW - Gzhelian
KW - Markley Formation
KW - Plantae
KW - Paleozoic
KW - Carboniferous
KW - Texas
KW - kaolinite
KW - organic compounds
KW - palynomorphs
KW - trees
KW - United States
KW - Paleosols
KW - stream sediments
KW - Pteridophyta
KW - drylands
KW - pollen
KW - Upper Pennsylvanian
KW - coal
KW - glacial environment
KW - sediments
KW - taphonomy
KW - miospores
KW - Midland Basin
KW - soils
KW - Coniferae
KW - Pangaea
KW - interglacial environment
KW - assemblages
KW - arid environment
KW - Gymnospermae
KW - cyclic processes
KW - statistical analysis
KW - Permian
KW - Asselian
KW - clay minerals
KW - spores
KW - peat
KW - lithofacies
KW - wetlands
KW - classification
KW - Lycopsida
KW - sheet silicates
KW - fluvial environment
KW - microfossils
KW - 09:Paleobotany
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832611679?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Review+of+Palaeobotany+and+Palynology&rft.atitle=Spatiotemporal+relationships+among+Late+Pennsylvanian+plant+assemblages%3B+palynological+evidence+from+the+Markley+Formation%2C+West+Texas%2C+U.S.A.&rft.au=Looy%2C+Cindy+V%3BHotton%2C+Carol+L&rft.aulast=Looy&rft.aufirst=Cindy&rft.date=2014-12-01&rft.volume=211&rft.issue=&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Review+of+Palaeobotany+and+Palynology&rft.issn=00346667&rft_id=info:doi/10.1016%2Fj.revpalbo.2014.09.007
L2 - http://www.sciencedirect.com/science/journal/00346667
LA - English
DB - GeoRef
N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands
N1 - Number of references - 222
N1 - Document feature - illus. incl. 2 plates, 1 table, chart
N1 - Last updated - 2017-01-24
N1 - CODEN - RPPYAX
N1 - SubjectsTermNotLitGenreText - arid environment; Asselian; assemblages; Carboniferous; Cisuralian; classification; clay minerals; climate change; coal; Coniferae; cyclic processes; drylands; fluvial environment; glacial environment; Gymnospermae; Gzhelian; interglacial environment; kaolinite; lithofacies; Lower Permian; Lycopsida; Markley Formation; microfossils; Midland Basin; miospores; organic compounds; Paleosols; Paleozoic; palynomorphs; Pangaea; peat; Pennsylvanian; Permian; Plantae; pollen; Pteridophyta; sedimentary rocks; sediments; sheet silicates; silicates; siliciclastics; soils; Spermatophyta; spores; statistical analysis; stream sediments; taphonomy; terrestrial environment; Texas; trees; United States; Upper Pennsylvanian; wetlands
DO - http://dx.doi.org/10.1016/j.revpalbo.2014.09.007
ER -
TY - JOUR
T1 - CD47 in the Tumor Microenvironment Limits Cooperation between Antitumor T-cell Immunity and Radiotherapy
AN - 1811903696; PQ0003457542
AB - These findings establish that blocking the immunosuppressive molecule CD47 on cytotoxic T cells can enhance antitumor immunity in the context of radiotherapy, with the potential to increase curative radiation responses. Although significant advances in radiotherapy have increased its effectiveness in many cancer settings, general strategies to widen the therapeutic window between normal tissue toxicity and malignant tumor destruction would still offer great value. CD47 blockade has been found to confer radioprotection to normal tissues while enhancing tumor radiosensitivity. Here, we report that CD47 blockade directly enhances tumor immunosurveillance by CD8+ T cells. Combining CD47 blockade with irradiation did not affect fibrosarcoma growth in T cell-deficient mice, whereas adoptive transfer of tumor-specific CD8+ T cells restored combinatorial efficacy. Furthermore, ablation of CD8+ T cells abolished radiotherapeutic response in immunocompetent syngeneic hosts. CD47 blockade in either target cells or effector cells was sufficient to enhance antigen-dependent CD8+ CTL-mediated tumor cell killing in vitro. In CD47-deficient syngeneic hosts, engrafted B16 melanomas were 50% more sensitive to irradiation, establishing that CD47 expression in the microenvironment was sufficient to limit tumor radiosensitivity. Mechanistic investigations revealed increased tumor infiltration by cytotoxic CD8+ T cells in a CD47-deficient microenvironment, with an associated increase in T cell-dependent intratumoral expression of granzyme B. Correspondingly, an inverse correlation between CD8+ T-cell infiltration and CD47 expression was observed in human melanomas. Our findings establish that blocking CD47 in the context of radiotherapy enhances antitumor immunity by directly stimulating CD8+ cytotoxic T cells, with the potential to increase curative responses. Cancer Res; 74(23); 6771-83. copyright 2014 AACR.
JF - Cancer Research
AU - Soto-Pantoja, David R
AU - Terabe, Masaki
AU - Ghosh, Arunima
AU - Ridnour, Lisa A
AU - DeGraff, William G
AU - Wink, David A
AU - Berzofsky, Jay A
AU - Roberts, David D
AD - Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, dr9y@nih.gov
Y1 - 2014/12/01/
PY - 2014
DA - 2014 Dec 01
SP - 6771
EP - 6783
PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States
VL - 74
IS - 23
SN - 0008-5472, 0008-5472
KW - Immunology Abstracts; Toxicology Abstracts
KW - Fibrosarcoma
KW - Radiotherapy
KW - Toxicity
KW - Tumors
KW - CD8 antigen
KW - Tumor cells
KW - Cancer
KW - Melanoma
KW - Effector cells
KW - Metastases
KW - granzyme B
KW - Cytotoxicity
KW - Radiation
KW - Immunosurveillance
KW - Radioprotection
KW - Lymphocytes T
KW - Adoptive transfer
KW - Radiosensitivity
KW - Microenvironments
KW - X 24390:Radioactive Materials
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811903696?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=CD47+in+the+Tumor+Microenvironment+Limits+Cooperation+between+Antitumor+T-cell+Immunity+and+Radiotherapy&rft.au=Soto-Pantoja%2C+David+R%3BTerabe%2C+Masaki%3BGhosh%2C+Arunima%3BRidnour%2C+Lisa+A%3BDeGraff%2C+William+G%3BWink%2C+David+A%3BBerzofsky%2C+Jay+A%3BRoberts%2C+David+D&rft.aulast=Soto-Pantoja&rft.aufirst=David&rft.date=2014-12-01&rft.volume=74&rft.issue=23&rft.spage=6771&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/10.1158%2F0008-5472.CAN-14-0037-T
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-08-01
N1 - Last updated - 2016-10-26
N1 - SubjectsTermNotLitGenreText - Fibrosarcoma; Radiotherapy; CD8 antigen; Tumors; Toxicity; Tumor cells; Cancer; Effector cells; Melanoma; Metastases; granzyme B; Cytotoxicity; Radiation; Immunosurveillance; Radioprotection; Adoptive transfer; Lymphocytes T; Microenvironments; Radiosensitivity
DO - http://dx.doi.org/10.1158/0008-5472.CAN-14-0037-T
ER -
TY - JOUR
T1 - Phase II Clinical Trial of Amatuximab, a Chimeric Antimesothelin Antibody with Pemetrexed and Cisplatin in Advanced Unresectable Pleural Mesothelioma
AN - 1808642784; PQ0003457449
AB - Purpose: Amatuximab is a chimeric monoclonal antibody to mesothelin, a cell surface glycoprotein highly expressed in malignant pleural mesothelioma (MPM). On the basis of its synergy with chemotherapy in preclinical studies, we evaluated the antitumor activity of amatuximab plus pemetrexed and cisplatin in patients with unresectable MPM.Experimental Design: In a single-arm phase II study, amatuximab (5 mg/kg) was administered on days 1 and 8 with pemetrexed (500 mg/m2) and cisplatin (75 mg/m2) on day 1 of 21-day cycles for up to six cycles. Patients with response or stable disease received amatuximab maintenance until disease progression. Primary endpoint was progression-free survival (PFS) at 6 months. Secondary endpoints were overall survival (OS), response rate, and safety.Results: Eighty-nine patients were enrolled at 26 centers. Median of five cycles (range, 1-6) of combination treatment was administered, and 56 (63%) patients received amatuximab maintenance. Combination therapy resulted in no overlapping toxicities. Eleven patients (12.4%) had amatuximab-related hypersensitivity reactions. Responses included partial responses in 33 (40%) and stable disease in 42 (51%). Six-month PFS rate was 51% [95% confidence interval (CI), 39.1-62.3)], median PFS was 6.1 months (95% CI, 5.8-6.4), and median OS was 14.8 months (95% CI, 12.4-18.5) with 29 patients alive at data cut-off.Conclusions: Amatuximab with pemetrexed and cisplatin was well tolerated with objective tumor response or stable disease rate of 90% by independent radiologic review. Although PFS was not significantly different from historical controls, the median OS was 14.8 months with a third of patients alive and 5 continuing to receive amatuximab at the time of analysis. Clin Cancer Res; 20(23); 5927-36. copyright 2014 AACR.
JF - Clinical Cancer Research
AU - Hassan, Raffit
AU - Kindler, Hedy L
AU - Jahan, Thierry
AU - Bazhenova, Lyudmila
AU - Reck, Martin
AU - Thomas, Anish
AU - Pastan, Ira
AU - Parno, Jeff
AU - O'Shannessy, Daniel J
AU - Fatato, Penny
AU - Maltzman, Julia D
AU - Wallin, Bruce A
AD - Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, hassanr@mail.nih.gov
Y1 - 2014/12/01/
PY - 2014
DA - 2014 Dec 01
SP - 5927
EP - 5936
PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States
VL - 20
IS - 23
SN - 1078-0432, 1078-0432
KW - Biotechnology and Bioengineering Abstracts
KW - Cell surface
KW - Data processing
KW - Monoclonal antibodies
KW - Chemotherapy
KW - Survival
KW - Tumors
KW - Toxicity
KW - Clinical trials
KW - Cancer
KW - Hypersensitivity
KW - Cisplatin
KW - mesothelioma
KW - Glycoproteins
KW - Antitumor activity
KW - W 30915:Pharmaceuticals & Vaccines
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808642784?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Phase+II+Clinical+Trial+of+Amatuximab%2C+a+Chimeric+Antimesothelin+Antibody+with+Pemetrexed+and+Cisplatin+in+Advanced+Unresectable+Pleural+Mesothelioma&rft.au=Hassan%2C+Raffit%3BKindler%2C+Hedy+L%3BJahan%2C+Thierry%3BBazhenova%2C+Lyudmila%3BReck%2C+Martin%3BThomas%2C+Anish%3BPastan%2C+Ira%3BParno%2C+Jeff%3BO%27Shannessy%2C+Daniel+J%3BFatato%2C+Penny%3BMaltzman%2C+Julia+D%3BWallin%2C+Bruce+A&rft.aulast=Hassan&rft.aufirst=Raffit&rft.date=2014-12-01&rft.volume=20&rft.issue=23&rft.spage=5927&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-0804
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-07-01
N1 - Last updated - 2016-08-17
N1 - SubjectsTermNotLitGenreText - Cell surface; Data processing; Monoclonal antibodies; Chemotherapy; Survival; Toxicity; Tumors; Clinical trials; Cancer; Hypersensitivity; Cisplatin; mesothelioma; Glycoproteins; Antitumor activity
DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-0804
ER -
TY - JOUR
T1 - Perceptions of cancer as a death sentence: Prevalence and consequences
AN - 1683509645
AB - Research suggests that perceiving cancer as a death sentence is a critical determinant of health care–seeking behaviors. However, there is limited information regarding the prevalence of this perception in the US population. Cross-sectional analysis of data (n = 7674 adults) from the 2007-2008 administration of the nationally representative Health Information National Trends Survey (HINTS 3) was performed. A majority (61.6%) of respondents perceived cancer as death sentence, and more than one-third (36%) of respondents reported that they avoid seeing their physicians. In the adult US population, perceiving cancer as a death sentence is common and is associated with education level and avoidance of physicians.
JF - Journal of Health Psychology
AU - Moser, Richard P
AU - Arndt, Jamie
AU - Han, Paul K
AU - Waters, Erika A
AU - Amsellem, Marni
AU - Hesse, Bradford W
AD - National Cancer Institute, USA ; University of Missouri, USA ; Maine Medical Center, USA ; Washington University School of Medicine, USA ; National Cancer Institute, SAIC-Frederick, USA ; National Cancer Institute, USA
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1518
EP - 1524
CY - London
PB - SAGE PUBLICATIONS, INC.
VL - 19
IS - 12
SN - 1359-1053
KW - Psychology
KW - cancer
KW - health behavior
KW - health psychology
KW - perception
KW - public health psychology
KW - Avoidance
KW - Mental health services
KW - Cancer
KW - Death
KW - Doctors
KW - Health behaviour
KW - Health care
KW - Health information
KW - Health psychology
KW - Perceptions
KW - United States--US
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683509645?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Psychology&rft.atitle=Perceptions+of+cancer+as+a+death+sentence%3A+Prevalence+and+consequences&rft.au=Moser%2C+Richard+P%3BArndt%2C+Jamie%3BHan%2C+Paul+K%3BWaters%2C+Erika+A%3BAmsellem%2C+Marni%3BHesse%2C+Bradford+W&rft.aulast=Moser&rft.aufirst=Richard&rft.date=2014-12-01&rft.volume=19&rft.issue=12&rft.spage=1518&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105313494924
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-05-19
N1 - Last updated - 2016-05-13
N1 - SubjectsTermNotLitGenreText - United States--US
DO - http://dx.doi.org/10.1177/1359105313494924
ER -
TY - JOUR
T1 - NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism
AN - 1680442107; PQ0001187868
AB - Objective: Obesity is a major health problem associated with high morbidity and mortality. NSAID-activated gene (NAG-1) is a TGF- beta superfamily member reported to alter adipose tissue levels in mice. We investigated whether hNAG-1 acts as a regulator of adiposity and energy metabolism.Design/Subjects:hNAG-1 mice, ubiquitously expressing hNAG-1, were placed on a control or high-fat diet for 12 weeks. hNAG-1-expressing B16/F10 melanoma cells were used in a xenograft model to deliver hNAG-1 to obese C57BL/6 mice. Results: As compared with wild-type littermates, transgenic hNAG-1 mice have less white fat and brown fat despite equivalent food intake, improved glucose tolerance, lower insulin levels and are resistant to dietary- and genetic-induced obesity. hNAG-1 mice are more metabolically active with higher energy expenditure. Obese C57BL/6 mice treated with hNAG-1-expressing xenografts show decreases in adipose tissue and serum insulin levels. hNAG-1 mice and obese mice treated with hNAG-1-expressing xenografts show increased thermogenic gene expression (UCP1, PGC1 alpha , ECH1, Cox8b, Dio2, Cyc1, PGC1 beta , PPAR alpha , Elvol3) in brown adipose tissue (BAT) and increased expression of lipolytic genes (Adrb3, ATGL, HSL) in both white adipose tissue (WAT) and BAT, consistent with higher energy metabolism. Conclusion: hNAG-1 modulates metabolic activity by increasing the expression of key thermogenic and lipolytic genes in BAT and WAT. hNAG-1 appears to be a novel therapeutic target in preventing and treating obesity and insulin resistance.
JF - International Journal of Obesity
AU - Chrysovergis, K
AU - Wang, X
AU - Kosak, J
AU - Lee, S-H
AU - Kim, J S
AU - Foley, J F
AU - Travlos, G
AU - Singh, S
AU - Baek, S J
AU - Eling, T E
AD - Laboratory of Molecular Carcinogenesis, NIEHS, NIH, Research Triangle Park, NC, USA
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1555
EP - 1564
PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom
VL - 38
IS - 12
SN - 0307-0565, 0307-0565
KW - Physical Education Index
KW - Obesity
KW - Animal subjects
KW - Objectives
KW - Fats
KW - Football (American)
KW - Diet
KW - Hormones
KW - Metabolism
KW - Professional sports
KW - PE 030:Exercise, Health & Physical Fitness
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680442107?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=NAG-1%2FGDF-15+prevents+obesity+by+increasing+thermogenesis%2C+lipolysis+and+oxidative+metabolism&rft.au=Chrysovergis%2C+K%3BWang%2C+X%3BKosak%2C+J%3BLee%2C+S-H%3BKim%2C+J+S%3BFoley%2C+J+F%3BTravlos%2C+G%3BSingh%2C+S%3BBaek%2C+S+J%3BEling%2C+T+E&rft.aulast=Chrysovergis&rft.aufirst=K&rft.date=2014-12-01&rft.volume=38&rft.issue=12&rft.spage=1555&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fijo.2014.27
LA - English
DB - Physical Education Index
N1 - Date revised - 2015-05-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Obesity; Objectives; Animal subjects; Football (American); Fats; Diet; Hormones; Professional sports; Metabolism
DO - http://dx.doi.org/10.1038/ijo.2014.27
ER -
TY - JOUR
T1 - Race and health profiles in the United States: an examination of the social gradient through the 2009 CHIS adult survey
AN - 1665171654
AB - The objective of this study is to examine the role of the social gradient on multiple health outcomes and behaviors. It was predicted that higher levels of SES, measured by educational attainment and family income, would be associated with positive health behaviors and health status. The study also examined the differential effects of the social gradient in health among different racial/ethnic groups. The study contributes to the literature by illustrating unique patterns and trends of the social gradient across various racial/ethnic populations in a nationally representative sample. Future studies should further explore temporal trends to track the impact of the social gradient for different racial and ethnic populations in tandem with indices of national income inequalities.
JF - Public Health
AU - Nguyen, A B
AU - Moser, R
AU - Chou, W-Y
AD - The National Cancer Institute (NCI), Division of Cancer Control and Population Sciences (DCCPS), 9609 Medical Center Dr., Rm 3E638, Rockville, MD 20850-9761, USA ; The National Cancer Institute (NCI), Division of Cancer Control and Population Sciences (DCCPS), 9609 Medical Center Dr., Rockville, MD 20850-9761, USA ; The National Cancer Institute (NCI), Division of Cancer Control and Population Sciences (DCCPS), 9609 Medical Center Dr., Rm 3E638, Rockville, MD 20850-9761, USA
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1076
EP - 1086
CY - Houndsmill
PB - Elsevier Science Ltd.
VL - 128
IS - 12
SN - 0033-3506
KW - Public Health And Safety
KW - Health disparities
KW - SES
KW - Race
KW - Ethnicity
KW - Social gradient
KW - Academic achievement
KW - Ethnic groups
KW - Health behaviour
KW - Health status
KW - Income inequalities
KW - Inequalities
KW - National income
KW - Socioeconomic status
KW - United States--US
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665171654?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health&rft.atitle=Race+and+health+profiles+in+the+United+States%3A+an+examination+of+the+social+gradient+through+the+2009+CHIS+adult+survey&rft.au=Nguyen%2C+A+B%3BMoser%2C+R%3BChou%2C+W-Y&rft.aulast=Nguyen&rft.aufirst=A&rft.date=2014-12-01&rft.volume=128&rft.issue=12&rft.spage=1076&rft.isbn=&rft.btitle=&rft.title=Public+Health&rft.issn=00333506&rft_id=info:doi/10.1016%2Fj.puhe.2014.10.003
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-02-24
N1 - Last updated - 2016-05-12
N1 - SubjectsTermNotLitGenreText - United States--US
DO - http://dx.doi.org/10.1016/j.puhe.2014.10.003
ER -
TY - JOUR
T1 - Cognitive problems among breast cancer survivors: loneliness enhances risk
AN - 1665162336
AB - Background Cancer survivors often experience cognitive difficulties after treatment completion. Although chemotherapy enhances risk for cognitive problems, it is likely only one piece of a complex puzzle that explains survivorsʼ cognitive functioning. Loneliness may be one psychosocial risk factor. The current studies included both subjective and objective cognitive measures and tested whether lonelier breast cancer survivors would have more concentration and memory complaints and experience more concentration difficulties than their less lonely counterparts. Methods The relationship between loneliness and cognitive function was tested among three samples of breast cancer survivors. Study 1 was a sample of breast cancer survivors ( n=200) who reported their concentration and memory problems. Study 2a was a sample of breast cancer survivors ( n=185) and noncancer controls ( n=93) who reported their concentration and memory problems. Study 2b was a subsample of Study 2a breast cancer survivors ( n=22) and noncancer controls ( n=21) who completed a standardized neuropsychological test assessing concentration. Results Studies 1 and 2a revealed that lonelier women reported more concentration and memory problems than less lonely women. Study 2b utilized a standardized neuropsychological continuous performance test and demonstrated that lonelier women experienced more concentration problems than their less lonely counterparts. Conclusions These studies demonstrated that loneliness is linked to concentration and memory complaints and the experience of concentration problems among breast cancer survivors. The results were also highly consistent across three samples of breast cancer survivors. These data suggest that loneliness may be a risk factor for cognitive difficulties among cancer survivors. Copyright © 2014 John Wiley & Sons, Ltd.
JF - Psycho-Oncology
AU - Jaremka, Lisa M
AU - Peng, Juan
AU - Bornstein, Robert
AU - Alfano, Catherine M
AU - Andridge, Rebecca R
AU - Povoski, Stephen P
AU - Lipari, Adele M
AU - Agnese, Doreen M
AU - Farrar, William B
AU - Yee, Lisa D
AU - Carson, William E
AU - Kiecolt-Glaser, Janice K
AD - Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA. ; Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA., College of Public Health, The Ohio State University College of Medicine, Columbus, OH, USA. ; Department of Psychiatry, The Ohio State University College of Medicine, Columbus, OH, USA. ; National Cancer Institute, Bethesda, MD, USA. ; College of Public Health, The Ohio State University College of Medicine, Columbus, OH, USA. ; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA., Department of Surgery, The Ohio State University College of Medicine, Columbus, OH, USA. ; Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA., Department of Psychiatry, The Ohio State University College of Medicine, Columbus, OH, USA., Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA. ; Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA.
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1356
EP - 1364
CY - Chichester
PB - Wiley Subscription Services, Inc.
VL - 23
IS - 12
SN - 1057-9249
KW - Medical Sciences--Psychiatry And Neurology
KW - Breast cancer
KW - Cancer
KW - Chemotherapy
KW - Clinical outcomes
KW - Cognitive functioning
KW - Complaints
KW - Concentration
KW - Continuous performance tasks
KW - Loneliness
KW - Memory
KW - Psychosocial factors
KW - Survivors
KW - Women
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665162336?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Cognitive+problems+among+breast+cancer+survivors%3A+loneliness+enhances+risk&rft.au=Jaremka%2C+Lisa+M%3BPeng%2C+Juan%3BBornstein%2C+Robert%3BAlfano%2C+Catherine+M%3BAndridge%2C+Rebecca+R%3BPovoski%2C+Stephen+P%3BLipari%2C+Adele+M%3BAgnese%2C+Doreen+M%3BFarrar%2C+William+B%3BYee%2C+Lisa+D%3BCarson%2C+William+E%3BKiecolt-Glaser%2C+Janice+K&rft.aulast=Jaremka&rft.aufirst=Lisa&rft.date=2014-12-01&rft.volume=23&rft.issue=12&rft.spage=1356&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.3544
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-01-09
N1 - Last updated - 2016-08-16
DO - http://dx.doi.org/10.1002/pon.3544
ER -
TY - JOUR
T1 - Disparities in Health Care Access and Receipt of Preventive Services by Disability Type: Analysis of the Medical Expenditure Panel Survey
AN - 1665151201
AB - OBJECTIVE: To examine differences in access to health care and receipt of clinical preventive services by type of disability among working-age adults with disabilities. DATA SOURCE: Secondary analysis of Medical Expenditure Panel Survey (MEPS) data from 2002 to 2008. STUDY DESIGN: We conducted cross-sectional logistic regression analyses comparing people with different types of disabilities on health insurance status and type; presence of a usual source of health care; delayed or forgone care; and receipt of dental checkups and cancer screening. DATA COLLECTION: We pooled annualized MEPS data files across years. Our analytic sample consisted of adults (18-64 years) with physical, sensory, or cognitive disabilities and nonmissing data for all variables of interest. PRINCIPAL FINDINGS: Individuals with hearing impairment had better health care access and receipt than people with other disability types. People with multiple types of limitations were especially likely to have health care access problems and unmet health care needs. CONCLUSIONS: There are differences in health care access and receipt of preventive care depending on what type of disability people have. More in-depth research is needed to identify specific causes of these disparities and assess interventions to address health care barriers for particular disability groups.
JF - Health Services Research
AU - Horner‐Johnson, Willi
AU - Dobbertin, Konrad
AU - Lee, Jae Chul
AU - Andresen, Elena M
AD - Institute on Development and Disability. Oregon Health and Science University ; Rehabilitation Medicine Department, Clinical Research Center. National Institutes of Health ; Institute on Development and Disability. Oregon Health and Science University
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1980
EP - 1999
CY - Chicago
PB - Wiley Subscription Services, Inc.
VL - 49
IS - 6
SN - 0017-9124
KW - Medical Sciences
KW - Disability
KW - Analysis
KW - Cancer
KW - Delayed
KW - Health costs
KW - Health insurance
KW - Health status
KW - Hearing
KW - Hearing impairment
KW - Insurance
KW - Interventions
KW - Learning disabled people
KW - Screening
KW - Service provision
KW - Unmet needs
KW - Expenditure
KW - Health care
KW - Health inequalities
KW - Preventive health care
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665151201?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Disparities+in+Health+Care+Access+and+Receipt+of+Preventive+Services+by+Disability+Type%3A+Analysis+of+the+Medical+Expenditure+Panel+Survey&rft.au=Horner%E2%80%90Johnson%2C+Willi%3BDobbertin%2C+Konrad%3BLee%2C+Jae+Chul%3BAndresen%2C+Elena+M&rft.aulast=Horner%E2%80%90Johnson&rft.aufirst=Willi&rft.date=2014-12-01&rft.volume=49&rft.issue=6&rft.spage=1980&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12195
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-01-09
N1 - Last updated - 2016-05-25
DO - http://dx.doi.org/10.1111/1475-6773.12195
ER -
TY - JOUR
T1 - Characterizing the Factor Structure of Parent Reported Executive Function in Autism Spectrum Disorders: The Impact of Cognitive Inflexibility
AN - 1665151191
AB - Parents of children with autism spectrum disorders (ASD) consistently report executive functioning (EF) deficits. This study investigates the factor structure of the Behavior Rating Inventory of Executive Function (BRIEF) as reported by parents of children with ASD and typically developing children (TDC). BRIEFs for 411 children with ASD and 467 TDC were examined. Confirmatory factor analysis of a nine-factor model met thresholds for goodness-of-fit in TDC, but not in the ASD sample. We found globally elevated EF problems in the ASD sample, especially on the Shift scale. These findings confirm that children with ASD exhibit significant EF deficits. Further investigation is needed to understand the pervasive nature of cognitive inflexibility in children with ASD.
JF - Journal of Autism and Developmental Disorders
AU - Granader, Yael
AU - Wallace, Gregory L
AU - Hardy, Kristina K
AU - Yerys, Benjamin E
AU - Lawson, Rachel A
AU - Rosenthal, Michael
AU - Wills, Meagan C
AU - Dixon, Eunice
AU - Pandey, Juhi
AU - Penna, Rebecca
AU - Schultz, Robert T
AU - Kenworthy, Lauren
AD - Children’s National Medical Center, 15245 Shady Grove Road, Suite 350, Rockville, MD, 20850, USA ygranade@childrensnational.org ygranade@childrensnational.org ygranade@childrensnational.org ygranade@childrensnational.org ygranade@childrensnational.org; Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USA, Department of Speech and Hearing Sciences, George Washington University, Washington, DC, USA ; Center for Autism Research, Children’s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA, USA ; Children’s National Medical Center, 15245 Shady Grove Road, Suite 350, Rockville, MD, 20850, USA, Loyola University Maryland, Baltimore, MD, USA ; Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USA ; Children’s National Medical Center, 15245 Shady Grove Road, Suite 350, Rockville, MD, 20850, USA
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 3056
EP - 3062
CY - New York
PB - Springer Science & Business Media
VL - 44
IS - 12
SN - 0162-3257
KW - Children And Youth - About
KW - Autism
KW - Autistic children
KW - Autistic spectrum disorders
KW - Children
KW - Confirmatory factor analysis
KW - Executive function
KW - Factor analysis
KW - Parents
KW - Thresholds
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665151191?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Characterizing+the+Factor+Structure+of+Parent+Reported+Executive+Function+in+Autism+Spectrum+Disorders%3A+The+Impact+of+Cognitive+Inflexibility&rft.au=Granader%2C+Yael%3BWallace%2C+Gregory+L%3BHardy%2C+Kristina+K%3BYerys%2C+Benjamin+E%3BLawson%2C+Rachel+A%3BRosenthal%2C+Michael%3BWills%2C+Meagan+C%3BDixon%2C+Eunice%3BPandey%2C+Juhi%3BPenna%2C+Rebecca%3BSchultz%2C+Robert+T%3BKenworthy%2C+Lauren&rft.aulast=Granader&rft.aufirst=Yael&rft.date=2014-12-01&rft.volume=44&rft.issue=12&rft.spage=3056&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-014-2169-8
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-01-09
N1 - Last updated - 2016-05-12
DO - http://dx.doi.org/10.1007/s10803-014-2169-8
ER -
TY - JOUR
T1 - Pathways between acculturation and health behaviors among residents of low-income housing: the mediating role of social and contextual factors
AN - 1660032497; 4650083
AB - Acculturation may influence health behaviors, yet mechanisms underlying its effect are not well understood. In this study, we describe relationships between acculturation and health behaviors among low-income housing residents, and examine whether these relationships are mediated by social and contextual factors. Residents of 20 low-income housing sites in the Boston metropolitan area completed surveys that assessed acculturative characteristics, social/contextual factors, and health behaviors. A composite acculturation scale was developed using latent class analysis, resulting in four distinct acculturative groups. Path analysis was used to examine interrelationships between acculturation, health behaviors, and social/contextual factors, specifically self-reported social ties, social support, stress, material hardship, and discrimination. Of the 828 respondents, 69% were born outside of the U.S. Less acculturated groups exhibited healthier dietary practices and were less likely to smoke than more acculturated groups. Acculturation had a direct effect on diet and smoking, but not physical activity. Acculturation also showed an indirect effect on diet through its relationship with material hardship. Our finding that material hardship mediated the relationship between acculturation and diet suggests the need to explicate the significant role of financial resources in interventions seeking to promote healthy diets among low-income immigrant groups. Future research should examine these social and contextual mediators using larger, population-based samples, preferably with longitudinal data. All rights reserved, Elsevier
JF - Social science and medicine
AU - Stoddard, Anne M
AU - Tamers, Sara
AU - Tucker-Seeley, Reginald D
AU - Sorensen, Glorian C
AU - Allen, Jennifer Dacey
AU - Caspi, Caitlin
AU - Yang, May
AU - Leyva, Bryan
AD - DanaFarber Cancer Institute ; University of Minnesota ; New England Research Institutes ; National Cancer Institute
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 26
EP - 36
VL - 123
SN - 0277-9536, 0277-9536
KW - Sociology
KW - Smoking
KW - Acculturation
KW - Social support
KW - Immigrants
KW - Social housing
KW - U.S.A.
KW - Low income
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660032497?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+science+and+medicine&rft.atitle=Pathways+between+acculturation+and+health+behaviors+among+residents+of+low-income+housing%3A+the+mediating+role+of+social+and+contextual+factors&rft.au=Stoddard%2C+Anne+M%3BTamers%2C+Sara%3BTucker-Seeley%2C+Reginald+D%3BSorensen%2C+Glorian+C%3BAllen%2C+Jennifer+Dacey%3BCaspi%2C+Caitlin%3BYang%2C+May%3BLeyva%2C+Bryan&rft.aulast=Stoddard&rft.aufirst=Anne&rft.date=2014-12-01&rft.volume=123&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Social+science+and+medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2014.10.034
LA - English
DB - International Bibliography of the Social Sciences (IBSS)
N1 - Date revised - 2015-03-02
N1 - Last updated - 2015-03-03
N1 - SubjectsTermNotLitGenreText - 539 3105 3198; 6232 8037; 11847 6045 5706; 11755 5707 6071 1542 11325; 7553 6271; 11938 11949 13521; 433 293 14
DO - http://dx.doi.org/10.1016/j.socscimed.2014.10.034
ER -
TY - JOUR
T1 - Beyond cry and laugh: Toward a multilevel model of language production
AN - 1660024893; 201507012
AB - Language production is a multilevel phenomenon, and human capacities to communicate vocally progress from early forms, based on projections of motor cortex to brainstem nuclei, to complex elaborations, mediated by high-order cognition and fostered by socially mediated feedback. Adapted from the source document.
JF - Behavioral and Brain Sciences
AU - Bornstein, Marc H
AU - Esposito, Gianluca
AD - Child and Family Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockledge I, Bethesda, MD 20892-7971, USA
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 548
EP - 549
PB - Cambridge University Press, New York NY
VL - 37
IS - 6
SN - 0140-525X, 0140-525X
KW - Brain
KW - Communication
KW - Social Factors
KW - Language
KW - article
KW - 1330: sociology of language and the arts; sociology of language/sociolinguistics
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660024893?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=Beyond+cry+and+laugh%3A+Toward+a+multilevel+model+of+language+production&rft.au=Bornstein%2C+Marc+H%3BEsposito%2C+Gianluca&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2014-12-01&rft.volume=37&rft.issue=6&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X13003968
LA - English
DB - Sociological Abstracts
N1 - Date revised - 2015-03-01
N1 - Number of references - 9
N1 - Last updated - 2016-09-28
N1 - CODEN - BBSCDH
N1 - SubjectsTermNotLitGenreText - Language; Communication; Brain; Social Factors
DO - http://dx.doi.org/10.1017/S0140525X13003968
ER -
TY - JOUR
T1 - Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial
AN - 1654693536; 21143840
AB - Background Chikungunya virus-a mosquito-borne alphavirus-is endemic in Africa and south and southeast Asia and has recently emerged in the Caribbean. No drugs or vaccines are available for treatment or prevention. We aimed to assess the safety, tolerability, and immunogenicity of a new candidate vaccine. Methods VRC 311 was a phase 1, dose-escalation, open-label clinical trial of a virus-like particle (VLP) chikungunya virus vaccine, VRC-CHKVLP059-00-VP, in healthy adults aged 18-50 years who were enrolled at the National Institutes of Health Clinical Center (Bethesda, MD, USA). Participants were assigned to sequential dose level groups to receive vaccinations at 10 mu g, 20 mu g, or 40 mu g on weeks 0, 4, and 20, with follow-up for 44 weeks after enrolment. The primary endpoints were safety and tolerability of the vaccine. Secondary endpoints were chikungunya virus-specific immune responses assessed by ELISA and neutralising antibody assays. This trial is registered with ClinicalTrials.gov, NCT01489358. Findings 25 participants were enrolled from Dec 12, 2011, to March 22, 2012, into the three dosage groups: 10 mu g (n=5), 20 mu g (n=10), and 40 mu g (n=10). The protocol was completed by all five participants at the 10 mu g dose, all ten participants at the 20 mu g dose, and eight of ten participants at the 40 mu g dose; non-completions were for personal circumstances unrelated to adverse events. 73 vaccinations were administered. All injections were well tolerated, with no serious adverse events reported. Neutralising antibodies were detected in all dose groups after the second vaccination (geometric mean titres of the half maximum inhibitory concentration: 2688 in the 10 mu g group, 1775 in the 20 mu g group, and 7246 in the 40 mu g group), and a significant boost occurred after the third vaccination in all dose groups (10 mu g group p=0.0197, 20 mu g group p<0.0001, and 40 mu g group p<0.0001). 4 weeks after the third vaccination, the geometric mean titres of the half maximum inhibitory concentration were 8745 for the 10 mu g group, 4525 for the 20 mu g group, and 5390 for the 40 mu g group. Interpretation The chikungunya VLP vaccine was immunogenic, safe, and well tolerated. This study represents an important step in vaccine development to combat this rapidly emerging pathogen. Further studies should be done in a larger number of participants and in more diverse populations. Funding Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, and National Institutes of Health.
JF - Lancet
AU - Chang, Lee-Jah
AU - Dowd, Kimberly A
AU - Mendoza, Floreliz H
AU - Saunders, Jamie G
AU - Sitar, Sandra
AU - Plummer, Sarah H
AU - Yamshchikov, Galina
AU - Sarwar, Uzma N
AU - Hu, Zonghui
AU - Enama, Mary E
AU - Bailer, Robert T
AU - Koup, Richard A
AU - Schwartz, Richard M
AU - Akahata, Wataru
AU - Nabel, Gary J
AU - Mascola, John R
AU - Pierson, Theodore C
AU - Graham, Barney S
AU - Ledgerwood, Julie E
AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 2046
EP - 2052
PB - Elsevier B.V., Radarweg 29 Amsterdam 1043 NX Netherlands
VL - 384
IS - 9959
SN - 0140-6736, 0140-6736
KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts
KW - Virus-like particles
KW - Disease control
KW - Clinical trials
KW - Public health
KW - Hypersensitivity
KW - Endemic species
KW - ASW, Caribbean Sea
KW - Infectious diseases
KW - ELISA
KW - Drugs
KW - Enzyme-linked immunosorbent assay
KW - Chikungunya virus
KW - Pathogens
KW - Vaccination
KW - USA
KW - Antibodies
KW - Immunogenicity
KW - Africa
KW - Immune response
KW - Vaccines
KW - ISEW, Southeast Asia
KW - Research programs
KW - V 22350:Immunology
KW - Q1 08604:Stock assessment and management
KW - Q5 08524:Public health, medicines, dangerous organisms
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654693536?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Safety+and+tolerability+of+chikungunya+virus-like+particle+vaccine+in+healthy+adults%3A+a+phase+1+dose-escalation+trial&rft.au=Chang%2C+Lee-Jah%3BDowd%2C+Kimberly+A%3BMendoza%2C+Floreliz+H%3BSaunders%2C+Jamie+G%3BSitar%2C+Sandra%3BPlummer%2C+Sarah+H%3BYamshchikov%2C+Galina%3BSarwar%2C+Uzma+N%3BHu%2C+Zonghui%3BEnama%2C+Mary+E%3BBailer%2C+Robert+T%3BKoup%2C+Richard+A%3BSchwartz%2C+Richard+M%3BAkahata%2C+Wataru%3BNabel%2C+Gary+J%3BMascola%2C+John+R%3BPierson%2C+Theodore+C%3BGraham%2C+Barney+S%3BLedgerwood%2C+Julie+E&rft.aulast=Chang&rft.aufirst=Lee-Jah&rft.date=2014-12-01&rft.volume=384&rft.issue=9959&rft.spage=2046&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2814%2961185-5
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-02-01
N1 - Last updated - 2016-12-22
N1 - SubjectsTermNotLitGenreText - Endemic species; Antibodies; Infectious diseases; Disease control; ELISA; Pathogens; Vaccines; Vaccination; Public health; Enzyme-linked immunosorbent assay; Virus-like particles; Clinical trials; Hypersensitivity; Immunogenicity; Immune response; Drugs; Research programs; Chikungunya virus; USA; ASW, Caribbean Sea; Africa; ISEW, Southeast Asia
DO - http://dx.doi.org/10.1016/S0140-6736(14)61185-5
ER -
TY - JOUR
T1 - Neural Correlates of Auditory Short-Term Memory in Rostral Superior Temporal Cortex
AN - 1647020733; 21221519
AB - Background: Auditory short-term memory (STM) in the monkey is less robust than visual STM and may depend on a retained sensory trace, which is likely to reside in the higherorder cortical areas of the auditory ventral stream. Results: We recorded from the rostral superior temporal cortex as monkeys performed serial auditory delayed match-tosample (DMS). A subset of neurons exhibited modulations of their firing rate during the delay between sounds, during the sensory response, or during both. This distributed subpopulation carried a predominantly sensory signal modulated by the mnemonic context of the stimulus. Excitatory and suppressive effects on match responses were dissociable in their timing and in their resistance to sounds intervening between the sample and match. Conclusions: Like the monkeys' behavioral performance, these neuronal effects differ from those reported in the same species during visual DMS, suggesting different neural mechanisms for retaining dynamic sounds and static images in STM.
JF - Current Biology
AU - Scott, Brian H
AU - Mortimer, Mishkin
AU - Pingbo, Yin
AD - Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA, brianscott@mail.nih.gov
Y1 - 2014/12/01/
PY - 2014
DA - 2014 Dec 01
SP - 2767
EP - 2775
PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 United States
VL - 24
IS - 23
SN - 0960-9822, 0960-9822
KW - CSA Neurosciences Abstracts; Ecology Abstracts
KW - Firing rate
KW - Neuromodulation
KW - Memory
KW - Cortex (visual)
KW - Neurons
KW - Subpopulations
KW - Cortex (temporal)
KW - Cortex (auditory)
KW - Short term memory
KW - Cortex (somatosensory)
KW - N3 11007:Neurobiology
KW - D 04040:Ecosystem and Ecology Studies
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647020733?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=Neural+Correlates+of+Auditory+Short-Term+Memory+in+Rostral+Superior+Temporal+Cortex&rft.au=Scott%2C+Brian+H%3BMortimer%2C+Mishkin%3BPingbo%2C+Yin&rft.aulast=Scott&rft.aufirst=Brian&rft.date=2014-12-01&rft.volume=24&rft.issue=23&rft.spage=2767&rft.isbn=&rft.btitle=&rft.title=Current+Biology&rft.issn=09609822&rft_id=info:doi/10.1016%2Fj.cub.2014.10.004
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-01-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Memory; Neuromodulation; Firing rate; Cortex (visual); Subpopulations; Neurons; Cortex (temporal); Cortex (auditory); Short term memory; Cortex (somatosensory)
DO - http://dx.doi.org/10.1016/j.cub.2014.10.004
ER -
TY - JOUR
T1 - Compounds with species and cell type specific toxicity identified in a 2000 compound drug screen of neural stem cells and rat mixed cortical neurons
AN - 1647009959; 21321507
AB - Human primary neural tissue is a vital component for the quick and simple determination of chemical compound neurotoxicity in vitro. In particular, such tissue would be ideal for high-throughput screens that can be used to identify novel neurotoxic or neurotherapeutic compounds. We have previously established a high-throughput screening platform using human induced pluripotent stem cell (iPSC)-derived neural stem cells (NSCs) and neurons. In this study, we conducted a 2000 compound screen with human NSCs and rat cortical cells to identify compounds that are selectively toxic to each group. Approximately 100 of the tested compounds showed specific toxicity to human NSCs. A secondary screen of a small subset of compounds from the primary screen on human iPSCs, NSC-derived neurons, and fetal astrocytes validated the results from >80% of these compounds with some showing cell specific toxicity. Amongst those compounds were several cardiac glycosides, all of which were selectively toxic to the human cells. As the screen was able to reliably identify neurotoxicants, many with species and cell-type specificity, this study demonstrates the feasibility of this NSC-driven platform for higher-throughput neurotoxicity screens.
JF - Neurotoxicology
AU - Malik, Nasir
AU - Efthymiou, Anastasia G
AU - Mather, Karly
AU - Chester, Nathaniel
AU - Wang, Xiantao
AU - Nath, Avindra
AU - Rao, Mahendra S
AU - Steiner, Joseph P
AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, United States
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 192
EP - 200
PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands
VL - 45
SN - 0161-813X, 0161-813X
KW - CSA Neurosciences Abstracts; Toxicology Abstracts
KW - Neurotoxicity screening
KW - Neural stem cells
KW - Cardiac glycosides
KW - Cortex
KW - Astrocytes
KW - Neurons
KW - Neurotoxicity
KW - Inhibitory postsynaptic potentials
KW - high-throughput screening
KW - Drugs
KW - Fetuses
KW - N3 11028:Neuropharmacology & toxicology
KW - X 24300:Methods
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647009959?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Compounds+with+species+and+cell+type+specific+toxicity+identified+in+a+2000+compound+drug+screen+of+neural+stem+cells+and+rat+mixed+cortical+neurons&rft.au=Malik%2C+Nasir%3BEfthymiou%2C+Anastasia+G%3BMather%2C+Karly%3BChester%2C+Nathaniel%3BWang%2C+Xiantao%3BNath%2C+Avindra%3BRao%2C+Mahendra+S%3BSteiner%2C+Joseph+P&rft.aulast=Malik&rft.aufirst=Nasir&rft.date=2014-12-01&rft.volume=45&rft.issue=&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2014.10.007
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-01-01
N1 - Last updated - 2016-05-13
N1 - SubjectsTermNotLitGenreText - Cortex; Astrocytes; Neurons; Inhibitory postsynaptic potentials; Neurotoxicity; high-throughput screening; Drugs; Neural stem cells; Cardiac glycosides; Fetuses
DO - http://dx.doi.org/10.1016/j.neuro.2014.10.007
ER -
TY - JOUR
T1 - Meeting the healthy people 2020 goals: using the health information national trends survey to monitor progress on health communication objectives
AN - 1646694103; 4635615
AB - The Healthy People initiative outlines a comprehensive set of goals aimed at improving the nation's health and reducing health disparities. Health communication has been included as an explicit goal since the launch of Healthy People 2010. The Health Information National Trends Survey (HINTS) was established as a means of exploring how the changing information environment was affecting the public's health, and is therefore an ideal tool for monitoring key health communication objectives included in the Healthy People agenda. In this article, the authors apply an integrative data analysis strategy to more than 10 years of HINTS data to demonstrate how public health surveillance can be used to evaluate broad national health goals, like those set forth under the Healthy People initiative. The authors analyzed just one item from the HINTS survey regarding Internet access in order to illustrate what public health surveillance tools, like HINTS, can reveal about important indicators that are of interest to all those who work to improve the health of the public. Results show that reported Internet penetration has exceeded the Healthy People 2020 target of 75.4%. HINTS data also allowed modeling of the effects of various sociodemographic factors, which revealed persistent differences on the basis of age and education, with the oldest age groups and those with less than a college education falling short of the Healthy People 2020 target as of 2013. Furthermore, although differences by race/ethnicity were observed, the analyses suggest that race in itself accounts for very little of the variance in Internet access. Reprinted by permission of Taylor & Francis Ltd.
JF - Journal of health communication
AU - Hesse, Bradford W
AU - Gaysynsky, Anna
AU - Ottenbacher, Allison
AU - Moser, Richard P
AU - Blake, Kelly D
AU - Chou, Wen-Ying Sylvia
AU - Vieux, Sana
AU - Beckjord, Ellen
AD - National Cancer Institute ; Patient-Centered Outcomes Research Institute ; University of Pittsburgh
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1497
EP - 1509
VL - 19
IS - 12
SN - 1081-0730, 1081-0730
KW - Sociology
KW - Information
KW - Objectivity
KW - Communication
KW - Surveillance
KW - Internet
KW - Public health
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1646694103?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Meeting+the+healthy+people+2020+goals%3A+using+the+health+information+national+trends+survey+to+monitor+progress+on+health+communication+objectives&rft.au=Hesse%2C+Bradford+W%3BGaysynsky%2C+Anna%3BOttenbacher%2C+Allison%3BMoser%2C+Richard+P%3BBlake%2C+Kelly+D%3BChou%2C+Wen-Ying+Sylvia%3BVieux%2C+Sana%3BBeckjord%2C+Ellen&rft.aulast=Hesse&rft.aufirst=Bradford&rft.date=2014-12-01&rft.volume=19&rft.issue=12&rft.spage=1497&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2014.954084
LA - English
DB - International Bibliography of the Social Sciences (IBSS)
N1 - Date revised - 2015-01-20
N1 - Last updated - 2015-01-20
N1 - SubjectsTermNotLitGenreText - 10449 5772; 2572; 6813 6518; 12424 6608 6085; 6515; 8826
DO - http://dx.doi.org/10.1080/10810730.2014.954084
ER -
TY - JOUR
T1 - Immune-based therapies for childhood cancer.
AN - 1645780841; 25348789
AB - After decades of research, immunotherapies for cancer are demonstrating increasing success. These agents can amplify existent antitumour immunity or induce durable antitumour immune responses in a wide array of cancers. The spectrum of immunotherapeutics is broad, spanning monoclonal antibodies and their derivatives, tumour vaccines, and adoptive therapies using T cells and natural killer cells. Only a small number of immunotherapies have been tested in paediatric cancers, but impressive antitumour effects have already been observed. Mononclonal antibodies targeting GD2 that induce antibody-dependent cell-mediated cytotoxicity improve survival in high-risk neuroblastoma. Bi-specific monoclonal antibodies that simultaneously target CD19 and activate T cells can induce remission in acute B-cell lymphoblastic leukaemia (B-ALL) and adoptive immunotherapy using T cells genetically engineered to express chimeric antigen receptors targeting CD19 induce impressive responses in B-ALL. Efforts are underway to generate and test new immunotherapies in a wider array of paediatric cancers. Major challenges include a need to identify immunotherapy targets on the most lethal childhood cancers, to expand availability of technology-intense platforms, such as adoptive cell therapy, to optimize management of novel toxicities associated with this new class of cancer therapies and to determine how best to incorporate these therapies into standard treatment paradigms.
JF - Nature reviews. Clinical oncology
AU - Mackall, Crystal L
AU - Merchant, Melinda S
AU - Fry, Terry J
AD - Paediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 10 Center Drive, MSC 1104, Bethesda, MD 20892, USA.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 693
EP - 703
VL - 11
IS - 12
KW - Index Medicus
KW - Humans
KW - Immunotherapy, Adoptive
KW - Child
KW - Neoplasms -- drug therapy
KW - Immunotherapy -- methods
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645780841?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Clinical+oncology&rft.atitle=Immune-based+therapies+for+childhood+cancer.&rft.au=Mackall%2C+Crystal+L%3BMerchant%2C+Melinda+S%3BFry%2C+Terry+J&rft.aulast=Mackall&rft.aufirst=Crystal&rft.date=2014-12-01&rft.volume=11&rft.issue=12&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Clinical+oncology&rft.issn=1759-4782&rft_id=info:doi/10.1038%2Fnrclinonc.2014.177
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-09
N1 - Date created - 2014-11-24
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1038/nrclinonc.2014.177
ER -
TY - JOUR
T1 - Base excision repair capacity in informing healthspan.
AN - 1645228453; 25355293
AB - Base excision repair (BER) is a frontline defense mechanism for dealing with many common forms of endogenous DNA damage, several of which can drive mutagenic or cell death outcomes. The pathway engages proteins such as glycosylases, abasic endonucleases, polymerases and ligases to remove substrate modifications from DNA and restore the genome back to its original state. Inherited mutations in genes related to BER can give rise to disorders involving cancer, immunodeficiency and neurodegeneration. Studies employing genetically defined heterozygous (haploinsufficient) mouse models indicate that partial reduction in BER capacity can increase vulnerability to both spontaneous and exposure-dependent pathologies. In humans, measurement of BER variation has been imperfect to this point, yet tools to assess BER in epidemiological surveys are steadily evolving. We provide herein an overview of the BER pathway and discuss the current efforts toward defining the relationship of BER defects with disease susceptibility.
Published by Oxford University Press 2014.
JF - Carcinogenesis
AU - Brenerman, Boris M
AU - Illuzzi, Jennifer L
AU - Wilson, David M
AD - Laboratory of Molecular Gerontology, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. ; Laboratory of Molecular Gerontology, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA wilsonda@mail.nih.gov.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 2643
EP - 2652
VL - 35
IS - 12
KW - Index Medicus
KW - Animals
KW - Humans
KW - Mice
KW - DNA Repair -- genetics
KW - Disease Susceptibility
KW - DNA Damage -- genetics
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645228453?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Base+excision+repair+capacity+in+informing+healthspan.&rft.au=Brenerman%2C+Boris+M%3BIlluzzi%2C+Jennifer+L%3BWilson%2C+David+M&rft.aulast=Brenerman&rft.aufirst=Boris&rft.date=2014-12-01&rft.volume=35&rft.issue=12&rft.spage=2643&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgu225
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-14
N1 - Date created - 2014-12-01
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/carcin/bgu225
ER -
TY - JOUR
T1 - Perceptions of cancer as a death sentence: prevalence and consequences
AN - 1642623125; 4630232
AB - Research suggests that perceiving cancer as a death sentence is a critical determinant of health care-seeking behaviors. However, there is limited information regarding the prevalence of this perception in the US population. Cross-sectional analysis of data (n = 7674 adults) from the 2007-2008 administration of the nationally representative Health Information National Trends Survey (HINTS 3) was performed. A majority (61.6%) of respondents perceived cancer as death sentence, and more than one-third (36%) of respondents reported that they avoid seeing their physicians. In the adult US population, perceiving cancer as a death sentence is common and is associated with education level and avoidance of physicians. Reprinted by permission of Sage Publications Ltd
JF - Journal of health psychology
AU - Moser, Richard
AU - Arndt, Jamie
AU - Han, Paul
AU - Waters, Erika
AU - Amsellem, Marni
AU - Hesse, Bradford
AD - National Cancer Institute, USA ; University of Missouri ; Maine Medical Center ; Washington University in St. Louis
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1518
EP - 1524
VL - 19
IS - 12
SN - 1359-1053, 1359-1053
KW - Sociology
KW - Doctors
KW - Health care
KW - Perception
KW - U.S.A.
KW - Cancer
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642623125?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+psychology&rft.atitle=Perceptions+of+cancer+as+a+death+sentence%3A+prevalence+and+consequences&rft.au=Moser%2C+Richard%3BArndt%2C+Jamie%3BHan%2C+Paul%3BWaters%2C+Erika%3BAmsellem%2C+Marni%3BHesse%2C+Bradford&rft.aulast=Moser&rft.aufirst=Richard&rft.date=2014-12-01&rft.volume=19&rft.issue=12&rft.spage=1518&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105313494924
LA - English
DB - International Bibliography of the Social Sciences (IBSS)
N1 - Date revised - 2015-01-07
N1 - Last updated - 2015-01-07
N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 9382; 5775 13521; 3675 10299 13682 7883 8864; 433 293 14
DO - http://dx.doi.org/10.1177/1359105313494924
ER -
TY - JOUR
T1 - Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation.
AN - 1640479642; 25536056
AB - Typically observed at 2 y after surgical resection, late recurrence is a major challenge in the management of hepatocellular carcinoma (HCC). We aimed to develop a genomic predictor that can identify patients at high risk for late recurrence and assess its clinical implications.
Systematic analysis of gene expression data from human liver undergoing hepatic injury and regeneration revealed a 233-gene signature that was significantly associated with late recurrence of HCC. Using this signature, we developed a prognostic predictor that can identify patients at high risk of late recurrence, and tested and validated the robustness of the predictor in patients (n = 396) who underwent surgery between 1990 and 2011 at four centers (210 recurrences during a median of 3.7 y of follow-up). In multivariate analysis, this signature was the strongest risk factor for late recurrence (hazard ratio, 2.2; 95% confidence interval, 1.3-3.7; p = 0.002). In contrast, our previously developed tumor-derived 65-gene risk score was significantly associated with early recurrence (p = 0.005) but not with late recurrence (p = 0.7). In multivariate analysis, the 65-gene risk score was the strongest risk factor for very early recurrence (<1 y after surgical resection) (hazard ratio, 1.7; 95% confidence interval, 1.1-2.6; p = 0.01). The potential significance of STAT3 activation in late recurrence was predicted by gene network analysis and validated later. We also developed and validated 4- and 20-gene predictors from the full 233-gene predictor. The main limitation of the study is that most of the patients in our study were hepatitis B virus-positive. Further investigations are needed to test our prediction models in patients with different etiologies of HCC, such as hepatitis C virus. Two independently developed predictors reflected well the differences between early and late recurrence of HCC at the molecular level and provided new biomarkers for risk stratification. Please see later in the article for the Editors' Summary.
JF - PLoS medicine
AU - Kim, Ji Hoon
AU - Sohn, Bo Hwa
AU - Lee, Hyun-Sung
AU - Kim, Sang-Bae
AU - Yoo, Jeong Eun
AU - Park, Yun-Yong
AU - Jeong, Woojin
AU - Lee, Sung Sook
AU - Park, Eun Sung
AU - Kaseb, Ahmed
AU - Kim, Baek Hui
AU - Kim, Wan Bae
AU - Yeon, Jong Eun
AU - Byun, Kwan Soo
AU - Chu, In-Sun
AU - Kim, Sung Soo
AU - Wang, Xin Wei
AU - Thorgeirsson, Snorri S
AU - Luk, John M
AU - Kang, Koo Jeong
AU - Heo, Jeonghoon
AU - Park, Young Nyun
AU - Lee, Ju-Seog
AD - Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Kleberg Center for Molecular Markers, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ; Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Kleberg Center for Molecular Markers, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America. ; Department of Pathology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. ; ASAN Institute for Life Sciences, Asan Medical Center, Department of Medicine, University of Ulsan College of Medicine, Seoul, Korea. ; Department of Life Sciences, Division of Life and Pharmaceutical Sciences, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea. ; Department of Hematology-Oncology, Inje University Haeundae Paik Hospital, Busan, Korea. ; Institute for Medical Convergence, Yonsei University College of Medicine, Seoul, Korea. ; Department of GI Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America. ; Department of Pathology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ; Department of Surgery, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ; Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea. ; Department of Biochemistry and Molecular Biology, Medical Research Center and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea. ; Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America. ; Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America. ; Department of Pharmacology, National University of Singapore, Singapore. ; Department of Surgery, Keimyung University School of Medicine, Daegu, Korea. ; Departments of Molecular Biology and Immunology, Kosin University College of Medicine, Busan, Korea. ; Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Kleberg Center for Molecular Markers, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Department of Biochemistry and Molecular Biology, Medical Research Center and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 1
VL - 11
IS - 12
KW - STAT3 Transcription Factor
KW - 0
KW - Index Medicus
KW - Young Adult
KW - Risk Factors
KW - Humans
KW - Adult
KW - Aged
KW - STAT3 Transcription Factor -- genetics
KW - Middle Aged
KW - Neoplasm Recurrence, Local -- genetics
KW - Male
KW - Female
KW - Multivariate Analysis
KW - Carcinoma, Hepatocellular -- genetics
KW - Liver Neoplasms -- genetics
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1640479642?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+medicine&rft.atitle=Genomic+predictors+for+recurrence+patterns+of+hepatocellular+carcinoma%3A+model+derivation+and+validation.&rft.au=Kim%2C+Ji+Hoon%3BSohn%2C+Bo+Hwa%3BLee%2C+Hyun-Sung%3BKim%2C+Sang-Bae%3BYoo%2C+Jeong+Eun%3BPark%2C+Yun-Yong%3BJeong%2C+Woojin%3BLee%2C+Sung+Sook%3BPark%2C+Eun+Sung%3BKaseb%2C+Ahmed%3BKim%2C+Baek+Hui%3BKim%2C+Wan+Bae%3BYeon%2C+Jong+Eun%3BByun%2C+Kwan+Soo%3BChu%2C+In-Sun%3BKim%2C+Sung+Soo%3BWang%2C+Xin+Wei%3BThorgeirsson%2C+Snorri+S%3BLuk%2C+John+M%3BKang%2C+Koo+Jeong%3BHeo%2C+Jeonghoon%3BPark%2C+Young+Nyun%3BLee%2C+Ju-Seog&rft.aulast=Kim&rft.aufirst=Ji&rft.date=2014-12-01&rft.volume=11&rft.issue=12&rft.spage=e1001770&rft.isbn=&rft.btitle=&rft.title=PLoS+medicine&rft.issn=1549-1676&rft_id=info:doi/10.1371%2Fjournal.pmed.1001770
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-01
N1 - Date created - 2014-12-24
N1 - Date revised - 2017-01-14
N1 - Genetic sequence - GSE39791; GEO; GSE22058; GSE15239; GSE14520; GSE12720
N1 - SuppNotes - Cited By:
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Hepatology. 2005 Jul;42(1):165-75 [15962318]
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J Am Coll Surg. 2006 Feb;202(2):275-83 [16427553]
Cancer Cell. 2006 Aug;10(2):99-111 [16904609]
Cancer Res. 2007 Mar 15;67(6):2497-507 [17363567]
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Clin Cancer Res. 2007 Nov 1;13(21):6275-83 [17975138]
Mol Oncol. 2014 Jul;8(5):1043-53 [24785097]
Liver Transpl. 2007 Dec;13(12):1669-77 [18044786]
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Clin Cancer Res. 2008 Apr 1;14(7):2056-64 [18381945]
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Pathology. 2008 Oct;40(6):558-63 [18752121]
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Mol Cancer Ther. 2011 Jan;10(1):9-15 [20971825]
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Clin Cancer Res. 2011 Sep 15;17(18):6040-51 [21825042]
J Clin Oncol. 2012 Mar 20;30(9):1005-14 [22355058]
J Gastrointest Surg. 2012 Apr;16(4):828-36 [22072303]
Gastroenterology. 2012 Apr;142(4):957-966.e12 [22202459]
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Front Med. 2013 Jun;7(2):242-54 [23681888]
Cancer. 2000 Aug 1;89(3):500-7 [10931448]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1371/journal.pmed.1001770
ER -
TY - JOUR
T1 - Nuclear imaging: A powerful novel approach for tuberculosis
AN - 1639993500; 21005737
AB - Nearly 20 years after the World Health Organization declared tuberculosis (TB) a global public health emergency, TB still remains a major global threat with 8.6 million new cases and 1.3 million deaths annually. Mycobacterium tuberculosis adapts to a quiescent physiological state, and is notable for complex interaction with the host, producing poorly-understood disease states ranging from latent infection to fully active disease. Of the approximately 2.5 billion people latently infected with M. tuberculosis, many will develop reactivation disease (relapse), years after the initial infection. In this review, we discuss the application of nuclear bioimaging to TB, including the current state of the field, considerations for radioprobe development, study of TB drug pharmacokinetics in infected tissues, and areas of research and clinical needs that could be addressed by nuclear bioimaging. Finally, since molecular imaging is readily available for humans, validated tracers will become valuable tools for clinical applications.
JF - Nuclear Medicine and Biology
AU - Johnson, Daniel H
AU - Via, Laura E
AU - Kim, Peter
AU - Laddy, Dominick
AU - Lau, Chuen-Yen
AU - Weinstein, Edward A
AU - Jain, Sanjay
AD - NIAID/NIH, Bethesda, MD; DAIDS/NIAID/NIH, 5601 Fisher Lane, Rm 9E39 MSC 9830, Rockville MD 20852, daniel.johnson@nih.gov
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 777
EP - 784
PB - Elsevier B.V., Box 882 New York NY 10159 United States
VL - 41
IS - 10
SN - 0969-8051, 0969-8051
KW - Microbiology Abstracts B: Bacteriology
KW - Drug-resistance
KW - PET
KW - SPECT
KW - Probe-design
KW - Pharmacokinetics
KW - Latent infection
KW - Tracers
KW - Computed tomography
KW - Nuclear medicine
KW - Therapeutic applications
KW - Tuberculosis
KW - Drug development
KW - Mycobacterium tuberculosis
KW - Public health
KW - J 02400:Human Diseases
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639993500?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Medicine+and+Biology&rft.atitle=Nuclear+imaging%3A+A+powerful+novel+approach+for+tuberculosis&rft.au=Johnson%2C+Daniel+H%3BVia%2C+Laura+E%3BKim%2C+Peter%3BLaddy%2C+Dominick%3BLau%2C+Chuen-Yen%3BWeinstein%2C+Edward+A%3BJain%2C+Sanjay&rft.aulast=Johnson&rft.aufirst=Daniel&rft.date=2014-12-01&rft.volume=41&rft.issue=10&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=Nuclear+Medicine+and+Biology&rft.issn=09698051&rft_id=info:doi/10.1016%2Fj.nucmedbio.2014.08.005
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Last updated - 2015-04-16
N1 - SubjectsTermNotLitGenreText - Tracers; Latent infection; Computed tomography; Therapeutic applications; Nuclear medicine; Drug development; Tuberculosis; Pharmacokinetics; Public health; Mycobacterium tuberculosis
DO - http://dx.doi.org/10.1016/j.nucmedbio.2014.08.005
ER -
TY - JOUR
T1 - endocrine-modulating effects on the ovarian steroidogenic pathway ex vivo independent of oxidative stress
AN - 1639992015; 21120955
AB - Gold nanoparticles (GNPs) have gained considerable attention for application in science and industry. However, the untoward effects of such particles on female fertility remain unclear. The objectives of this study were to (1) examine the effects of 10-nm GNPs on progesterone and estradiol-17 beta accumulation by rat ovaries ex vivo and (2) to identify the locus/loci whereby GNPs modulate steroidogenesis via multiple-reference gene quantitative real-time RT-PCR. Regression analyses indicated a positive relationship between both Star (p < 0.05, r super(2) = 0.278) and Cyp11a1 (p < 0.001, r super(2) = 0.366) expression and P4 accumulation upon exposure to 1.43 106 GNPs/mL. Additional analyses showed that E2 accumulation was positively associated with Hsd3b1 (p < 0.05, r super(2) = 0.181) and Cyp17a1 (p < 0.01, r super(2) = 0.301) expression upon exposure to 1.43 1 super(3) and 1.43 10 super(9) GNPs/mL, respectively. These results suggest a subtle treatment-dependent impact of low-dose GNPs on the relationship between progesterone or estradiol-17 beta and specific steroidogenic target genes, independent of oxidative stress or inhibin.
JF - Nanotoxicology
AU - Larson, Jeremy K
AU - Carvan, Michael J, III
AU - Teeguarden, Justin G
AU - Watanabe, Gen
AU - Taya, Kazuyoshi
AU - Krystofiak, Evan
AU - Hutz, Reinhold J
AD - University of Wisconsin-Milwaukee, Biological Sciences, Milwaukee, WI, USA; University of Wisconsin-Milwaukee and Children's Research Institute, NIEHS Children's Environmental Health Sciences Core Center, Milwaukee, WI, USA, rjhutz@uwm.edu
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 856
EP - 866
PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA
VL - 8
IS - 8
SN - 1743-5390, 1743-5390
KW - Toxicology Abstracts
KW - nanotoxicology
KW - genomics
KW - Fertility
KW - Progesterone
KW - Oxidative stress
KW - Inhibin
KW - Regression analysis
KW - Gold
KW - Polymerase chain reaction
KW - Ovaries
KW - nanoparticles
KW - Steroidogenesis
KW - X 24300:Methods
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639992015?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=endocrine-modulating+effects+on+the+ovarian+steroidogenic+pathway+ex+vivo+independent+of+oxidative+stress&rft.au=Larson%2C+Jeremy+K%3BCarvan%2C+Michael+J%2C+III%3BTeeguarden%2C+Justin+G%3BWatanabe%2C+Gen%3BTaya%2C+Kazuyoshi%3BKrystofiak%2C+Evan%3BHutz%2C+Reinhold+J&rft.aulast=Larson&rft.aufirst=Jeremy&rft.date=2014-12-01&rft.volume=8&rft.issue=8&rft.spage=856&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2013.837208
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Last updated - 2016-05-13
N1 - SubjectsTermNotLitGenreText - Fertility; Progesterone; Inhibin; Oxidative stress; Regression analysis; Polymerase chain reaction; Gold; Ovaries; Steroidogenesis; nanoparticles
DO - http://dx.doi.org/10.3109/17435390.2013.837208
ER -
TY - JOUR
T1 - A Generic Approach to Pathological Lung Segmentation
AN - 1639980148; 21125565
AB - In this study, we propose a novel pathological lung segmentation method that takes into account neighbor prior constraints and a novel pathology recognition system. Our proposed framework has two stages; during stage one, we adapted the fuzzy connectedness (FC) image segmentation algorithm to perform initial lung parenchyma extraction. In parallel, we estimate the lung volume using rib-cage information without explicitly delineating lungs. This rudimentary, but intelligent lung volume estimation system allows comparison of volume differences between rib cage and FC based lung volume measurements. Significant volume difference indicates the presence of pathology, which invokes the second stage of the proposed framework for the refinement of segmented lung. In stage two, texture-based features are utilized to detect abnormal imaging patterns (consolidations, ground glass, interstitial thickening, tree-inbud, honeycombing, nodules, and micro-nodules) that might have been missed during the first stage of the algorithm. This refinement stage is further completed by a novel neighboring anatomy-guided segmentation approach to include abnormalities with weak textures, and pleura regions. We evaluated the accuracy and efficiency of the proposed method on more than 400 CT scans with the presence of a wide spectrum of abnormalities. To our best of knowledge, this is the first study to evaluate all abnormal imaging patterns in a single segmentation framework. The quantitative results show that our pathological lung segmentation method improves on current standards because of its high sensitivity and specificity and may have considerable potential to enhance the performance of routine clinical tasks.
JF - IEEE Transactions on Medical Imaging
AU - Mansoor, Awais
AU - Bagci, Ulas
AU - Xu, Ziyue
AU - Foster, Brent
AU - Olivier, Kenneth N
AU - Elinoff, Jason M
AU - Suffredini, Anthony F
AU - Udupa, Jayaram K
AU - Mollura, Daniel J
AD - Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda,
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 2293
EP - 2310
PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 United States
VL - 33
IS - 12
SN - 0278-0062, 0278-0062
KW - Biotechnology and Bioengineering Abstracts
KW - Parenchyma
KW - Rib
KW - Pleura
KW - Lung
KW - Computed tomography
KW - Segmentation
KW - Algorithms
KW - Image processing
KW - Nodules
KW - W 30910:Imaging
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639980148?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Medical+Imaging&rft.atitle=A+Generic+Approach+to+Pathological+Lung+Segmentation&rft.au=Mansoor%2C+Awais%3BBagci%2C+Ulas%3BXu%2C+Ziyue%3BFoster%2C+Brent%3BOlivier%2C+Kenneth+N%3BElinoff%2C+Jason+M%3BSuffredini%2C+Anthony+F%3BUdupa%2C+Jayaram+K%3BMollura%2C+Daniel+J&rft.aulast=Mansoor&rft.aufirst=Awais&rft.date=2014-12-01&rft.volume=33&rft.issue=12&rft.spage=2293&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Medical+Imaging&rft.issn=02780062&rft_id=info:doi/10.1109%2FTMI.2014.2337057
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Last updated - 2015-03-20
N1 - SubjectsTermNotLitGenreText - Parenchyma; Pleura; Rib; Lung; Computed tomography; Algorithms; Segmentation; Image processing; Nodules
DO - http://dx.doi.org/10.1109/TMI.2014.2337057
ER -
TY - JOUR
T1 - Reporter mice express green fluorescent protein at initiation of meiosis in spermatocytes.
AN - 1639493430; 25293348
AB - Transgenic mice were generated using a heat shock protein 2 (Hspa2) gene promoter to express green fluorescent protein (GFP) at the beginning of meiotic prophase I in spermatocytes. Expression was confirmed in four lines by in situ fluorescence, immunohistochemistry, western blotting, and PCR assays. The expression and distribution of the GFP and HSPA2 proteins co-localized in spermatocytes and spermatids in three lines, but GFP expression was variegated in one line (F46), being present in some clones of meiotic and post-meiotic germ cells and not in others. Fluorescence activated cell sorting (FACS) was used to isolate purified populations of spermatocytes and spermatids. Although bisulfite sequencing revealed differences in the DNA methylation patterns in the promoter regions of the transgene of the variegated expressing GFP line, a uniformly expressing GFP reporter line, and the Hspa2 gene, these differences did not correlate with variegated expression. The Hspa2-GFP reporter mice provide a novel tool for studies of meiosis by allowing detection of GFP in situ and in isolated spermatogenic cells. They will allow sorting of meiotic and post-meiotic germ cells for characterization of molecular features and correlation of expression of GFP with stage-specific spermatogenic cell proteins and developmental events.
© 2014 Wiley Periodicals, Inc.
JF - Genesis (New York, N.Y. : 2000)
AU - Brown, Paula R
AU - Odet, Fanny
AU - Bortner, Carl D
AU - Eddy, Edward M
AD - Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 976
EP - 984
VL - 52
IS - 12
KW - HSP70 Heat-Shock Proteins
KW - 0
KW - Hspa2 protein, mouse
KW - Recombinant Proteins
KW - Green Fluorescent Proteins
KW - 147336-22-9
KW - Index Medicus
KW - variegated gene expression
KW - spermatogenesis
KW - heat shock protein
KW - fluorescence activated cell sorting
KW - Animals
KW - Promoter Regions, Genetic
KW - Spermatids -- cytology
KW - DNA Methylation
KW - Recombinant Proteins -- metabolism
KW - Spermatids -- metabolism
KW - Mice
KW - Recombinant Proteins -- genetics
KW - Mice, Transgenic
KW - Male
KW - Female
KW - Spermatocytes -- cytology
KW - HSP70 Heat-Shock Proteins -- metabolism
KW - HSP70 Heat-Shock Proteins -- genetics
KW - Meiosis
KW - Spermatocytes -- metabolism
KW - Green Fluorescent Proteins -- metabolism
KW - Green Fluorescent Proteins -- genetics
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639493430?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genesis+%28New+York%2C+N.Y.+%3A+2000%29&rft.atitle=Reporter+mice+express+green+fluorescent+protein+at+initiation+of+meiosis+in+spermatocytes.&rft.au=Brown%2C+Paula+R%3BOdet%2C+Fanny%3BBortner%2C+Carl+D%3BEddy%2C+Edward+M&rft.aulast=Brown&rft.aufirst=Paula&rft.date=2014-12-01&rft.volume=52&rft.issue=12&rft.spage=976&rft.isbn=&rft.btitle=&rft.title=Genesis+%28New+York%2C+N.Y.+%3A+2000%29&rft.issn=1526-968X&rft_id=info:doi/10.1002%2Fdvg.22830
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-08-14
N1 - Date created - 2014-12-19
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Cell. 1991 Jul 12;66(1):77-83 [1649008]
Cold Spring Harb Perspect Biol. 2013 Aug;5(8):a017780 [23906716]
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Nucleic Acids Res. 2008 Apr;36(7):2320-9 [18296483]
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Cytogenet Genome Res. 2010;128(1-3):46-56 [20389037]
Nucleic Acids Res. 2000 Sep 1;28(17):3301-9 [10954598]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1002/dvg.22830
ER -
TY - JOUR
T1 - Linking cancer genome to proteome: NCI's investment into proteogenomics
AN - 1639473894; 21123868
AB - Advances in both targeted and unbiased MS-based proteomics are now at a mature stage for comprehensively and reproducibly characterizing a large part of the cancer proteome. These developments combined with the extensive genomic characterization of several cancer types by large-scale initiatives such as the International Cancer Genome Consortium and Cancer Genome Atlas Project have paved the way for proteogenomic analysis of omics datasets and integration methods. The advances serve as the basis for the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium and this article highlights its current work and future steps in the area of proteogenomics.
JF - Proteomics
AU - Rivers, Robert C
AU - Kinsinger, Christopher
AU - Boja, Emily S
AU - Hiltke, Tara
AU - Mesri, Mehdi
AU - Rodriguez, Henry
AD - Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD, USA.
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 2633
EP - 2636
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 14
IS - 23-24
SN - 1615-9853, 1615-9853
KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW - Genomes
KW - Integration
KW - Atlases
KW - proteomics
KW - Tumors
KW - genomics
KW - Cancer
KW - G 07880:Human Genetics
KW - W 30960:Bioinformatics & Computer Applications
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639473894?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Linking+cancer+genome+to+proteome%3A+NCI%27s+investment+into+proteogenomics&rft.au=Rivers%2C+Robert+C%3BKinsinger%2C+Christopher%3BBoja%2C+Emily+S%3BHiltke%2C+Tara%3BMesri%2C+Mehdi%3BRodriguez%2C+Henry&rft.aulast=Rivers&rft.aufirst=Robert&rft.date=2014-12-01&rft.volume=14&rft.issue=23-24&rft.spage=2633&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159853&rft_id=info:doi/10.1002%2Fpmic.201400193
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Last updated - 2015-02-12
N1 - SubjectsTermNotLitGenreText - Genomes; Integration; Atlases; genomics; Tumors; proteomics; Cancer
DO - http://dx.doi.org/10.1002/pmic.201400193
ER -
TY - JOUR
T1 - Delayed uric Acid accumulation in plasma provides additional anti-oxidant protection against iron-triggered oxidative stress after a wingate test.
AN - 1637562479; 25435669
AB - Reactive oxygen species are produced during anaerobic exercise mostly by Fe ions released into plasma and endothelial/muscle xanthine oxidase activation that generates uric acid (UA) as the endpoint metabolite. Paradoxically, UA is considered a major antioxidant by virtue of being able to chelate pro-oxidative iron ions. This work aimed to evaluate the relationship between UA and plasma markers of oxidative stress following the exhaustive Wingate test. Plasma samples of 17 male undergraduate students were collected before, 5 and 60 min after maximal anaerobic effort for the measurement of total iron, haem iron, UA, ferric-reducing antioxidant activity in plasma (FRAP), and malondialdehyde (MDA, biomarker of lipoperoxidation). Iron and FRAP showed similar kinetics in plasma, demonstrating an adequate pro-/antioxidant balance immediately after exercise and during the recovery period (5-60 min). Slight variations of haem iron concentrations did not support a relevant contribution of rhabdomyolysis or haemolysis for iron overload following exercise. UA concentration did not vary immediately after exercise but rather increased 29% during the recovery period. Unaltered MDA levels were concomitantly measured. We propose that delayed UA accumulation in plasma is an auxiliary antioxidant response to post-exercise (iron-mediated) oxidative stress, and the high correlation between total UA and FRAP in plasma (R-Square = 0.636; p = 0.00582) supports this hypothesis.
JF - Biology of sport
AU - Souza-Junior, Tp
AU - Lorenço-Lima, L
AU - Ganini, D
AU - Vardaris, Cv
AU - Polotow, Tg
AU - Barros, Mp
AD - Department of Physical Education, Federal University of Parana (UFPR), Curitiba, PR, Brazil. ; Postgraduate program in Human Movement Sciences, Institute of Physical Activity and Sports Sciences (ICAFE), Cruzeiro do Sul University, Sao Paulo, SP, Brazil. ; Free Radical Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIEHS, Research Triangle Park, USA.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 271
EP - 276
VL - 31
IS - 4
SN - 0860-021X, 0860-021X
KW - anaerobic metabolism
KW - haemoglobin
KW - exercise
KW - xanthine oxidase
KW - lipid peroxidation
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+sport&rft.atitle=Delayed+uric+Acid+accumulation+in+plasma+provides+additional+anti-oxidant+protection+against+iron-triggered+oxidative+stress+after+a+wingate+test.&rft.au=Souza-Junior%2C+Tp%3BLoren%C3%A7o-Lima%2C+L%3BGanini%2C+D%3BVardaris%2C+Cv%3BPolotow%2C+Tg%3BBarros%2C+Mp&rft.aulast=Souza-Junior&rft.aufirst=Tp&rft.date=2014-12-01&rft.volume=31&rft.issue=4&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Biology+of+sport&rft.issn=0860021X&rft_id=info:doi/10.5604%2F20831862.1120934
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-12-01
N1 - Date created - 2014-12-01
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.5604/20831862.1120934
ER -
TY - JOUR
T1 - Stochastic dynamic models and Chebyshev splines
AN - 1636460761; 4625632
AB - In this article, we establish a connection between a stochastic dynamic model (SDM) driven by a linear stochastic differential equation (SDE) and a Chebyshev spline, which enables researchers to borrow strength across fields both theoretically and numerically. We construct a differential operator for the penalty function and develop a reproducing kernel Hilbert space (RKHS) induced by the SDM and the Chebyshev spline. The general form of the linear SDE allows us to extend the well-known connection between an integrated Brownian motion and a polynomial spline to a connection between more complex diffusion processes and Chebyshev splines. One interesting special case is connection between an integrated Ornstein-Uhlenbeck process and an exponential spline. We use two real data sets to illustrate the integrated Ornstein– ;Uhlenbeck process model and exponential spline model and show their estimates are almost identical. The Canadian Journal of Statistics 42: 610-634; 2014 © 2014 Statistical Society of Canada // ABSTRACT IN : Les auteurs établissent un lien entre un modèle stochastique dynamique basé sur une équation différentielle stochastique linéaire et une spline de Chebyshev, permettant aux chercheurs de transférer des connaissances dans ces champs respectifs, autant d'un point de vue théorique que numé ;rique. Ils construisent un opérateur différentiel pour la fonction de pénalité et développent un espace de Hilbert à noyau reproduisant découlant du modèle stochastique dynamique et de la spline de Chebyshev. La forme générale de l'équation différentielle stochastique linéaire permet de généraliser le lien bien connu entre un mouvement brownien intégré et une spline polynomiale à un lien entre des processus de diffusion plus complexes et les splines de Chebyshev. Un cas particulier d'intérêt lie un processus d'Ornstein-Uhlenbeck intégré et une spline exponentielle. Les auteurs utilisent deux jeux de données réelles pour illustrer le processus d'Ornstein-Uhlenbeck intégré et un modèle de spline exponentielle. Ils montrent que les estimés obtenus sont presque identiques. La revue canadienne de statistique xx: 1-25; 2014 © 2014 Société statistique du Canada
JF - Canadian journal of statistics
AU - Fan, Ruzong
AU - Zhu, Bin
AU - Wang, Yuedong
AD - National Institutes of Health ; University of California, Santa Barbara
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 610
EP - 634
VL - 42
IS - 4
SN - 0319-5724, 0319-5724
KW - Economics
KW - Stochastic processes
KW - Statistics
KW - Dynamic models
KW - Canada
KW - Economic models
KW - Diffusionism
KW - Functional analysis
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+statistics&rft.atitle=Stochastic+dynamic+models+and+Chebyshev+splines&rft.au=Fan%2C+Ruzong%3BZhu%2C+Bin%3BWang%2C+Yuedong&rft.aulast=Fan&rft.aufirst=Ruzong&rft.date=2014-12-01&rft.volume=42&rft.issue=3&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Analytical+and+bioanalytical+chemistry&rft.issn=1618-2650&rft_id=info:doi/10.1007%2Fs00216-014-8118-8
LA - English
DB - International Bibliography of the Social Sciences (IBSS)
N1 - Date revised - 2014-12-16
N1 - Last updated - 2014-12-16
N1 - SubjectsTermNotLitGenreText - 12265 3865 4025 10214 12224 971 12228 10919; 3786 8163; 3555 1073; 5345 971; 12233; 3969 8163; 75 293 14
DO - http://dx.doi.org/10.1002/cjs.11233
ER -
TY - JOUR
T1 - Identification of Fragile X Syndrome Specific Molecular Markers in Human Fibroblasts: A Useful Model to Test the Efficacy of Therapeutic Drugs
AN - 1635035222; 21045979
AB - Fragile X syndrome (FXS) is the most frequent cause of inherited intellectual disability and autism. It is caused by the absence of the fragile X mental retardation 1 (FMR1) gene product, fragile X mental retardation protein (FMRP), an RNA-binding protein involved in the regulation of translation of a subset of brain mRNAs. In Fmr1 knockout mice, the absence of FMRP results in elevated protein synthesis in the brain as well as increased signaling of many translational regulators. Whether protein synthesis is also dysregulated in FXS patients is not firmly established. Here, we demonstrate that fibroblasts from FXS patients have significantly elevated rates of basal protein synthesis along with increased levels of phosphorylated mechanistic target of rapamycin (p-mTOR), phosphorylated extracellular signal regulated kinase 1/2, and phosphorylated p70 ribosomal S6 kinase 1 (p-S6K1). The treatment with small molecules that inhibit S6K1 and a known FMRP target, phosphoinositide 3-kinase (PI3K) catalytic subunit p110 beta , lowered the rates of protein synthesis in both control and patient fibroblasts. Our data thus demonstrate that fibroblasts from FXS patients may be a useful in vitro model to test the efficacy and toxicity of potential therapeutics prior to clinical trials, as well as for drug screening and designing personalized treatment approaches. We show that primary fibroblasts from fragile X syndrome (FXS) patients have elevated rates of protein synthesis and increased levels of translational regulators, p-mTOR and p-S6K1. Treatment with inhibitors of S6K1 and PI3K reduces rates of protein synthesis in these cells. Our data suggest that primary fibroblasts from FXS patients can be a useful cell-based model for high-throughput drug screens, evaluation of potential therapeutic compounds and designing personalized treatment approaches.
JF - Human Mutation
AU - Kumari, Daman
AU - Bhattacharya, Aditi
AU - Nadel, Jeffrey
AU - Moulton, Kristen
AU - Zeak, Nicole M
AU - Glicksman, Anne
AU - Dobkin, Carl
AU - Brick, David J
AU - Schwartz, Philip H
AU - Smith, Carolyn B
AU - Klann, Eric
AU - Usdin, Karen
AD - Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1485
EP - 1494
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 35
IS - 12
SN - 1059-7794, 1059-7794
KW - Genetics Abstracts; Toxicology Abstracts
KW - FMR1 protein
KW - Translation
KW - Protein biosynthesis
KW - Data processing
KW - RNA-binding protein
KW - Brain
KW - Catalytic subunits
KW - Drug development
KW - Toxicity
KW - fragile X mental retardation protein
KW - Drug screening
KW - Clinical trials
KW - Fibroblasts
KW - 1-Phosphatidylinositol 3-kinase
KW - Fragile X syndrome
KW - Ribosomal protein S6 kinase
KW - Mental retardation
KW - Drugs
KW - Autism
KW - X 24310:Pharmaceuticals
KW - G 07710:Chemical Mutagenesis & Radiation
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Mutation&rft.atitle=Identification+of+Fragile+X+Syndrome+Specific+Molecular+Markers+in+Human+Fibroblasts%3A+A+Useful+Model+to+Test+the+Efficacy+of+Therapeutic+Drugs&rft.au=Kumari%2C+Daman%3BBhattacharya%2C+Aditi%3BNadel%2C+Jeffrey%3BMoulton%2C+Kristen%3BZeak%2C+Nicole+M%3BGlicksman%2C+Anne%3BDobkin%2C+Carl%3BBrick%2C+David+J%3BSchwartz%2C+Philip+H%3BSmith%2C+Carolyn+B%3BKlann%2C+Eric%3BUsdin%2C+Karen&rft.aulast=Kumari&rft.aufirst=Daman&rft.date=2014-12-01&rft.volume=35&rft.issue=12&rft.spage=1485&rft.isbn=&rft.btitle=&rft.title=Human+Mutation&rft.issn=10597794&rft_id=info:doi/10.1002%2Fhumu.22699
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Last updated - 2015-03-04
N1 - SubjectsTermNotLitGenreText - Translation; FMR1 protein; Data processing; Protein biosynthesis; RNA-binding protein; Brain; Catalytic subunits; Drug development; Toxicity; Drug screening; fragile X mental retardation protein; Clinical trials; Fibroblasts; 1-Phosphatidylinositol 3-kinase; Fragile X syndrome; Ribosomal protein S6 kinase; Mental retardation; Autism; Drugs
DO - http://dx.doi.org/10.1002/humu.22699
ER -
TY - JOUR
T1 - Association of seropositivity to Helicobacter species and biliary tract cancer in the ATBC study
AN - 1635032490; 21045942
AB - Helicobacter have been detected in human bile and hepatobiliary tissue. Despite evidence that Helicobacter species promote gallstone formation and hepatobiliary tumors in laboratory studies, it remains unclear whether Helicobacter species contribute to these cancers in humans. We used a multiplex panel to assess whether seropositivity to 15 Helicobacter pylori proteins was associated with subsequent incidence of hepatobiliary cancers in the Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. We included 64 biliary cancers, 122 liver cancers, and 224 age-matched controls which occurred over the course of 22 years. Helicobacter pylori seropositivity was defined as those positive to greater than or equal to 4 antigens. Odds ratios (OR) and 95% confidence intervals were adjusted for major hepatobiliary cancer risk factors. Among the controls, 88% were seropositive to H. pylori at baseline. Among those who subsequently developed hepatobiliary cancer, the prevalence of seropositivity was higher: 100% for gallbladder cancer, 97% of extrahepatic bile duct cancer, 91% of ampula of Vater cancer, 96% of intrahepatic bile duct cancer, and 94% of hepatocellular carcinoma. Although the OR for gallbladder cancer could not be calculated, the OR for the other sites were 7.01 (95% confidence interval [CI]: 0.79-62.33), 2.21 (0.19-25.52), 10.67 (0.76-150.08), and 1.20 (0.42-3.45), respectively, with an OR of 5.47 (95% CI: 1.17-25.65) observed for the biliary tract cancers combined. ORs above 1 were observed for many of the investigated antigens, although most of these associations were not statistically significant. Conclusion: Seropositivity to H. pylori proteins was associated with an increased risk of biliary tract cancers in ATBC. Further studies are needed to confirm our findings and to determine how H. pylori might influence the risk of biliary tract cancer. (Hepatology 2014; 60:1962-1970)
JF - Hepatology
AU - Murphy, Gwen
AU - Michel, Angelika
AU - Taylor, Philip R
AU - Albanes, Demetrius
AU - Weinstein, Stephanie J
AU - Virtamo, Jarmo
AU - Parisi, Dominick
AU - Snyder, Kirk
AU - Butt, Julia
AU - McGlynn, Katherine A
AU - Koshiol, Jill
AU - Pawlita, Michael
AU - Lai, Gabriel Y
AU - Abnet, Christian C
AU - Dawsey, Sanford M
AU - Freedman, Neal D
AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1963
EP - 1971
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 60
IS - 6
SN - 0270-9139, 0270-9139
KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW - Helicobacter pylori
KW - Gallbladder
KW - Bile duct
KW - Liver cancer
KW - Risk factors
KW - Statistical analysis
KW - Tumors
KW - Biliary tract
KW - Hepatocellular carcinoma
KW - J 02400:Human Diseases
KW - F 06910:Microorganisms & Parasites
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology&rft.atitle=Association+of+seropositivity+to+Helicobacter+species+and+biliary+tract+cancer+in+the+ATBC+study&rft.au=Murphy%2C+Gwen%3BMichel%2C+Angelika%3BTaylor%2C+Philip+R%3BAlbanes%2C+Demetrius%3BWeinstein%2C+Stephanie+J%3BVirtamo%2C+Jarmo%3BParisi%2C+Dominick%3BSnyder%2C+Kirk%3BButt%2C+Julia%3BMcGlynn%2C+Katherine+A%3BKoshiol%2C+Jill%3BPawlita%2C+Michael%3BLai%2C+Gabriel+Y%3BAbnet%2C+Christian+C%3BDawsey%2C+Sanford+M%3BFreedman%2C+Neal+D&rft.aulast=Murphy&rft.aufirst=Gwen&rft.date=2014-12-01&rft.volume=60&rft.issue=6&rft.spage=1963&rft.isbn=&rft.btitle=&rft.title=Hepatology&rft.issn=02709139&rft_id=info:doi/10.1002%2Fhep.27193
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Last updated - 2015-03-04
N1 - SubjectsTermNotLitGenreText - Gallbladder; Bile duct; Risk factors; Liver cancer; Statistical analysis; Tumors; Biliary tract; Hepatocellular carcinoma; Helicobacter pylori
DO - http://dx.doi.org/10.1002/hep.27193
ER -
TY - JOUR
T1 - Wistar rats acquire and maintain self-administration of 20 % ethanol without water deprivation, saccharin/sucrose fading, or extended access training
AN - 1635028166; 21030598
AB - Rationale: Operant self-administration (SA) is an important model of motivation to consume ethanol (EtOH), but low rates of voluntary consumption in rats are thought to necessitate water deprivation and saccharin/sucrose fading for acquisition of responding. Objectives: Here, we sought to devise an effective model of SA that does not use water deprivation or saccharin/sucrose fading. Methods: First, we tested if Wistar rats would acquire and maintain SA behavior of 20 % EtOH under two conditions, water deprivation (WD) and non-water deprivation (NWD). Second, we tested the efficacy of our SA procedure by confirming a prior study which found that the NK1 antagonist L822429 specifically blocked stress-induced reinstatement of EtOH seeking but not SA. Finally, we assessed the effect of naltrexone, an FDA-approved medication for alcohol dependence that has been shown to suppress EtOH SA in rodents. Results: Lever presses (LPs) and rewards were consistent with previous reports that utilized WD and saccharin/sucrose fading. Similar to previous findings, we found that L822429 blocked stress-induced reinstatement but not baseline SA of 20 % EtOH. Moreover, naltrexone dose-dependently decreased alcohol intake and motivation to consume alcohol for rats that are self-administering 20 % EtOH. Conclusions: Our findings provide a method for voluntary oral EtOH SA in rats that is convenient for experimenters and eliminates the potential confound of sweeteners in EtOH-operant SA studies. Unlike models that use intermittent access to 20 % EtOH, this method does not induce escalation, and based on pharmacological experiments, it appears to be driven by the positive reinforcing effects of EtOH.
JF - Psychopharmacology
AU - Augier, E
AU - Flanigan, M
AU - Dulman, R S
AU - Pincus, A
AU - Schank, J R
AU - Rice, K C
AU - Kejun, C
AU - Heilig, M
AU - Tapocik, J D
AD - Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA, eric.augier@nih.gov
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 4561
EP - 4568
PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands
VL - 231
IS - 23
SN - 0033-3158, 0033-3158
KW - Physical Education Index; Animal Behavior Abstracts; CSA Neurosciences Abstracts
KW - Alcohol
KW - Saccharin
KW - Alcoholic beverages
KW - Operant conditioning
KW - Sweeteners
KW - Motivation
KW - Animal subjects
KW - Medications
KW - Reinstatement
KW - Water
KW - Models
KW - Drug dependence
KW - Reward
KW - Behavior
KW - Sucrose
KW - Naltrexone
KW - Reinforcement
KW - Lipopolysaccharides
KW - Drug self-administration
KW - Ethanol
KW - Self efficacy
KW - N3 11001:Behavioral and Cognitive Neuroscience
KW - Y 25130:Methodology
KW - PE 090:Sports Medicine & Exercise Sport Science
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Wistar+rats+acquire+and+maintain+self-administration+of+20+%25+ethanol+without+water+deprivation%2C+saccharin%2Fsucrose+fading%2C+or+extended+access+training&rft.au=Augier%2C+E%3BFlanigan%2C+M%3BDulman%2C+R+S%3BPincus%2C+A%3BSchank%2C+J+R%3BRice%2C+K+C%3BKejun%2C+C%3BHeilig%2C+M%3BTapocik%2C+J+D&rft.aulast=Augier&rft.aufirst=E&rft.date=2014-12-01&rft.volume=231&rft.issue=23&rft.spage=4561&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-014-3605-3
LA - English
DB - Physical Education Index
N1 - Date revised - 2014-12-01
N1 - Number of references - 24
N1 - Last updated - 2015-03-04
N1 - SubjectsTermNotLitGenreText - Alcohol; Behavior; Reward; Motivation; Animal subjects; Medications; Water; Self efficacy; Saccharin; Alcoholic beverages; Sweeteners; Operant conditioning; Reinstatement; Models; Drug dependence; Sucrose; Naltrexone; Reinforcement; Lipopolysaccharides; Ethanol; Drug self-administration
DO - http://dx.doi.org/10.1007/s00213-014-3605-3
ER -
TY - JOUR
T1 - Q and B values are critical measurements required for inter-instrument standardization and development of multicolor flow cytometry staining panels
AN - 1635027765; 21033485
AB - Much of the complexity of multicolor flow cytometry experiments lies within the development of antibody staining panels and the standardization of instruments. In this article, we propose a theoretical metric and describe how measurements of sensitivity and resolution can be used to predict the success of panels, and ensure that performance across instruments is standardized (i.e., inter-instrument standardization). Sensitivity can be determined by summing two major contributors of background, background originating from the instrument (optical noise and electronic noise) and background due to the experimental conditions (i.e., Raman scatter, and spillover spreading arising from other fluorochromes in the panel). The former we define as B sub(cal) and the latter we define as B sub(sos). The combination of instrument and experiment background is defined as B sub(tot). Importantly, the B sub(tot) will affect the degree of panel separation, therefore the greater the degree of B sub(tot) the lower the separation potential. In contrast, resolution is a measure of separation between populations. Resolution is directly proportional to the number of photoelectrons generated per molecule of excited fluorochrome and is known as the "Q" value. Q and B sub(tot) values can be used to define the performance of each detector on an instrument and together they can be used to calculate a separation index. Hence, detectors with known Q and B sub(tot) values can be used to evaluate panel success based on the detector specific separation index. However, the current technologies do not enable measurements of Q and B sub(tot) values for all parameters, but new technology to allow these measurements will likely be introduced in the near future. Nonetheless, Q and B sub(tot) measurements can aid in panel development, and reveal sources of instrument-to-instrument variation in panel performance. In addition, Q and B values can form the basis for a comprehensive and versatile quality assurance program. Published 2014 Wiley Periodicals Inc.
JF - Cytometry Part A
AU - Perfetto, Stephen P
AU - Chattopadhyay, Pratip K
AU - Wood, James
AU - Nguyen, Richard
AU - Ambrozak, David
AU - Hill, Juliane P
AU - Roederer, Mario
AD - Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, 20724.
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1037
EP - 1048
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 85
IS - 12
SN - 1552-4922, 1552-4922
KW - Biotechnology and Bioengineering Abstracts
KW - Flow cytometry
KW - Standardization
KW - Antibodies
KW - Spreading
KW - Quality control
KW - fluorochromes
KW - W 30900:Methods
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635027765?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Q+and+B+values+are+critical+measurements+required+for+inter-instrument+standardization+and+development+of+multicolor+flow+cytometry+staining+panels&rft.au=Perfetto%2C+Stephen+P%3BChattopadhyay%2C+Pratip+K%3BWood%2C+James%3BNguyen%2C+Richard%3BAmbrozak%2C+David%3BHill%2C+Juliane+P%3BRoederer%2C+Mario&rft.aulast=Perfetto&rft.aufirst=Stephen&rft.date=2014-12-01&rft.volume=85&rft.issue=12&rft.spage=1037&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524922&rft_id=info:doi/10.1002%2Fcyto.a.22579
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Last updated - 2014-12-11
N1 - SubjectsTermNotLitGenreText - Flow cytometry; Standardization; Antibodies; Spreading; Quality control; fluorochromes
DO - http://dx.doi.org/10.1002/cyto.a.22579
ER -
TY - JOUR
T1 - Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland
AN - 1635026371; 21029934
AB - Purpose : Concerns regarding a possible link between bisphenol A (BPA) and breast cancer have been mounting, but studies in human populations are lacking. We evaluated the association between the major urinary BPA metabolite [BPA-glucuronide (BPA-G)] and postmenopausal breast cancer risk in a large population-based case-control study conducted in two cities in Poland (2000-2003); we further explored the association of BPA-G levels with known postmenopausal breast cancer risk factors in our control population. Methods: We analyzed creatinine-adjusted urinary BPA-G levels among 575 postmenopausal cases matched on age and study site to 575 controls without breast cancer using a recently developed assay. Odds ratios and 95 % confidence intervals were used to estimate the association between urinary BPA-G level and breast cancer using conditional logistic regression. Among controls, geometric mean BPA-G levels were compared across categories of breast cancer risk factors using linear regression models. Results: There was no indication that increased BPA-G was associated with postmenopausal breast cancer (p-trend = 0.59). Among controls, mean BPA-G was higher among women reporting extended use of menopausal hormones, a prior screening mammogram, and residence in Warsaw. Other comparisons across strata of postmenopausal breast cancer risk factors were not related to differences in BPA-G. Conclusions: Urinary BPA-G, measured at the time of diagnosis, is not linked to postmenopausal breast cancer.
JF - Cancer Causes & Control
AU - Trabert, Britton
AU - Falk, Roni T
AU - Figueroa, Jonine D
AU - Graubard, Barry I
AU - Garcia-Closas, Montserrat
AU - Lissowska, Jolanta
AU - Peplonska, Beata
AU - Fox, Stephen D
AU - Brinton, Louise A
AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 7E-228, Bethesda, MD, 20892-9774, USA, britton.trabert@nih.gov
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 1587
EP - 1593
PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands
VL - 25
IS - 12
SN - 0957-5243, 0957-5243
KW - Risk Abstracts; Health & Safety Science Abstracts
KW - Bisphenol A
KW - Health risks
KW - Cities
KW - Age
KW - Post-menopause
KW - Urine
KW - Poland
KW - Human populations
KW - Breast cancer
KW - Metabolites
KW - Hormones
KW - H 6000:Natural Disasters/Civil Defense/Emergency Management
KW - R2 23060:Medical and environmental health
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635026371?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Urinary+bisphenol+A-glucuronide+and+postmenopausal+breast+cancer+in+Poland&rft.au=Trabert%2C+Britton%3BFalk%2C+Roni+T%3BFigueroa%2C+Jonine+D%3BGraubard%2C+Barry+I%3BGarcia-Closas%2C+Montserrat%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BFox%2C+Stephen+D%3BBrinton%2C+Louise+A&rft.aulast=Trabert&rft.aufirst=Britton&rft.date=2014-12-01&rft.volume=25&rft.issue=12&rft.spage=1587&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-014-0461-8
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Number of references - 27
N1 - Last updated - 2015-02-12
N1 - SubjectsTermNotLitGenreText - Bisphenol A; Cities; Health risks; Age; Urine; Post-menopause; Human populations; Breast cancer; Metabolites; Hormones; Poland
DO - http://dx.doi.org/10.1007/s10552-014-0461-8
ER -
TY - JOUR
T1 - Role of nucleotide excision repair and p53 in zidovudine (AZT)-induced centrosomal deregulation.
AN - 1634498926; 25073973
AB - The nucleoside reverse transcriptase inhibitor zidovudine (AZT) induces genotoxic damage that includes centrosomal amplification (CA > 2 centrosomes/cell) and micronucleus (MN) formation. Here we explored these end points in mice deficient in DNA repair and tumor suppressor function to evaluate their effect on AZT-induced DNA damage. We used mesenchymal-derived fibroblasts cultured from C57BL/6J mice that were null and wild type (WT) for Xpa, and WT, haploinsufficient and null for p53 (6 different genotypes). Dose-responses for CA formation, in cells exposed to 0, 10, and 100 μM AZT for 24 hr, were observed in all genotypes except the Xpa((+/+)) p53((+/-)) cells, which had very low levels of CA, and the Xpa((-/-)) p53((-/-)) cells, which had very high levels of CA. For CA there was a significant three-way interaction between Xpa, p53, and AZT concentration, and Xpa((-/-)) cells had significantly higher levels of CA than Xpa((+/+)) cells, only for p53((+/-)) cells. In contrast, the MN and MN + chromosomes (MN + C) data showed a lack of AZT dose response. The Xpa((-/-)) cells, with p53((+/+)) or ((+/-)) genotypes, had levels of MN and MN + C higher than the corresponding Xpa((+/+)) cells. The data show that CA is a major event induced by exposure to AZT in these cells, and that there is a complicated relationship between AZT and CA formation with respect to gene dosage of Xpa and p53. The loss of both genes resulted in high levels of damage, and p53 haploinsufficicency strongly protected Xpa((+/+)) cells from AZT-induced CA damage.
Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
JF - Environmental and molecular mutagenesis
AU - Momot, Dariya
AU - Nostrand, Terri A
AU - John, Kaarthik
AU - Ward, Yvona
AU - Steinberg, Seth M
AU - Liewehr, David J
AU - Poirier, Miriam C
AU - Olivero, Ofelia A
AD - Carcinogen-DNA Interactions Section, LCBG, National Cancer Institute, NIH, Bethesda, Maryland.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 719
EP - 726
VL - 55
IS - 9
KW - Tumor Suppressor Protein p53
KW - 0
KW - Xeroderma Pigmentosum Group A Protein
KW - Xpa protein, mouse
KW - Zidovudine
KW - 4B9XT59T7S
KW - Index Medicus
KW - micronuclei with whole chromosomes
KW - centrosomal amplification
KW - Xpa
KW - zidovudine
KW - micronuclei
KW - Cell Proliferation -- drug effects
KW - Bone Marrow Cells -- drug effects
KW - Animals
KW - Micronucleus Tests
KW - Cell Survival -- drug effects
KW - Dose-Response Relationship, Drug
KW - Mice, Inbred C57BL
KW - Mice, Transgenic
KW - Xeroderma Pigmentosum Group A Protein -- genetics
KW - DNA Repair -- genetics
KW - Zidovudine -- toxicity
KW - Centrosome -- drug effects
KW - Tumor Suppressor Protein p53 -- genetics
KW - DNA Repair -- drug effects
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-04-28
N1 - Date created - 2014-11-17
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1002/em.21889
ER -
TY - JOUR
T1 - Mitochondria, energetics, epigenetics, and cellular responses to stress.
AN - 1629966890; 25127496
AB - Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP production but also through metabolites generated in the tricarboxylic acid cycle, as well as mitochondria-nuclear signaling related to mitochondria morphology, biogenesis, fission/fusion, mitophagy, apoptosis, and epigenetic regulation.
We investigated the concept of bidirectional interactions between mitochondria and cellular pathways in response to environmental stress with a focus on epigenetic regulation, and we examined DNA repair and DDR pathways as examples of biological processes that respond to exogenous insults through changes in homeostasis and altered mitochondrial function. The National Institute of Environmental Health Sciences sponsored the Workshop on Mitochondria, Energetics, Epigenetics, Environment, and DNA Damage Response on 25-26 March 2013. Here, we summarize key points and ideas emerging from this meeting.
A more comprehensive understanding of signaling mechanisms (cross-talk) between the mitochondria and nucleus is central to elucidating the integration of mitochondrial functions with other cellular response pathways in modulating the effects of environmental agents. Recent studies have highlighted the importance of mitochondrial functions in epigenetic regulation and DDR with environmental stress. Development and application of novel technologies, enhanced experimental models, and a systems-type research approach will help to discern how environmentally induced mitochondrial dysfunction affects key mechanistic pathways. Understanding mitochondria-cell signaling will provide insight into individual responses to environmental hazards, improving prediction of hazard and susceptibility to environmental stressors.
JF - Environmental health perspectives
AU - Shaughnessy, Daniel T
AU - McAllister, Kimberly
AU - Worth, Leroy
AU - Haugen, Astrid C
AU - Meyer, Joel N
AU - Domann, Frederick E
AU - Van Houten, Bennett
AU - Mostoslavsky, Raul
AU - Bultman, Scott J
AU - Baccarelli, Andrea A
AU - Begley, Thomas J
AU - Sobol, Robert W
AU - Hirschey, Matthew D
AU - Ideker, Trey
AU - Santos, Janine H
AU - Copeland, William C
AU - Tice, Raymond R
AU - Balshaw, David M
AU - Tyson, Frederick L
AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 1271
EP - 1278
VL - 122
IS - 12
KW - DNA, Mitochondrial
KW - 0
KW - Environmental Pollutants
KW - Index Medicus
KW - DNA, Mitochondrial -- drug effects
KW - DNA Damage
KW - Humans
KW - Genome, Mitochondrial
KW - DNA, Mitochondrial -- genetics
KW - Environmental Pollutants -- toxicity
KW - Mitochondria -- drug effects
KW - Environmental Exposure
KW - Environmental Pollutants -- administration & dosage
KW - Mitochondria -- genetics
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Mitochondria%2C+energetics%2C+epigenetics%2C+and+cellular+responses+to+stress.&rft.au=Shaughnessy%2C+Daniel+T%3BMcAllister%2C+Kimberly%3BWorth%2C+Leroy%3BHaugen%2C+Astrid+C%3BMeyer%2C+Joel+N%3BDomann%2C+Frederick+E%3BVan+Houten%2C+Bennett%3BMostoslavsky%2C+Raul%3BBultman%2C+Scott+J%3BBaccarelli%2C+Andrea+A%3BBegley%2C+Thomas+J%3BSobol%2C+Robert+W%3BHirschey%2C+Matthew+D%3BIdeker%2C+Trey%3BSantos%2C+Janine+H%3BCopeland%2C+William+C%3BTice%2C+Raymond+R%3BBalshaw%2C+David+M%3BTyson%2C+Frederick+L&rft.aulast=Shaughnessy&rft.aufirst=Daniel&rft.date=2014-12-01&rft.volume=122&rft.issue=12&rft.spage=1271&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408418
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-13
N1 - Date created - 2014-12-02
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1289/ehp.1408418
ER -
TY - JOUR
T1 - A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood.
AN - 1629965619; 25281486
AB - Lung cancer has a familial component which suggests a genetic contribution to its etiology. Given the strong evidence linking smoking with lung cancer, we studied miRNA-related loci in genes associated with smoking behavior. CHRNA, CHRNB gene families, CYP2A6, and DRD1 (dopamine receptor D1) were mined for SNPs that fell within the seed region of miRNA binding sites and then tested for associations with risk in a three-stage validation approach. A 3'UTR (untranslated region) SNP in DRD1 was associated with a lower risk of lung cancer among individuals exposed to secondhand smoke during childhood [OR, 0.69; 95% confidence interval (CI), 0.60-0.79; P < 0.0001]. This relationship was evident in both ever (OR, 0.74; 95% CI, 0.62-0.88; P = 0.001) and never smokers (OR, 0.61; 95% CI, 0.47-0.79; P < 0.0001), European American (OR, 0.65; 95% CI, 0.53-0.80; P < 0.0001), and African American (OR, 0.73; 95% CI, 0.62-0.88; P = 0.001) populations. Although much remains undefined about the long-term risks associated with exposure to secondhand smoke and heterogeneity between individuals in regard to their susceptibility to the effects of secondhand smoke, our data show an interaction between an SNP in the 3'UTR of DRD1 and exposure to secondhand smoke during childhood. Further work is needed to explore the mechanistic underpinnings of this SNP and the nature of the interaction between DRD1 and exposure to secondhand smoke during childhood.
©2014 American Association for Cancer Research.
JF - Cancer prevention research (Philadelphia, Pa.)
AU - Robles, Ana I
AU - Yang, Ping
AU - Jen, Jin
AU - McClary, Andrew C
AU - Calhoun, Kara
AU - Bowman, Elise D
AU - Vähäkangas, Kirsi
AU - Greathouse, K Leigh
AU - Wang, Yi
AU - Olivo-Marston, Susan
AU - Wenzlaff, Angela S
AU - Deng, Bo
AU - Schwartz, Ann G
AU - Ryan, Bríd M
AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. ; Mayo Clinic, Department of Health Sciences Research, Rochester, Minnesota. ; Department of Laboratory Medicine and Pathology and Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota. ; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. Department of Pathology, Stanford University Hospital and Clinics, Stanford, California. ; School of Pharmacy/Toxicology, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland. ; Division of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China. Division of Epidemiology, Health Sciences Research, Mayo Clinic, Rochester, Minnesota. ; Division of Epidemiology, College of Public Health, Ohio State University, Columbus, Ohio. ; Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan. ; Division of Epidemiology, Health Sciences Research, Mayo Clinic, Rochester, Minnesota. Thoracic Surgery Department, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing, China. ; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. ryanb@mail.nih.gov.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 1210
EP - 1218
VL - 7
IS - 12
KW - 3' Untranslated Regions
KW - 0
KW - CHRNA1 protein, human
KW - CHRNA2 protein, human
KW - DRD1 protein, human
KW - MicroRNAs
KW - Receptors, Dopamine D1
KW - Receptors, Nicotinic
KW - Tobacco Smoke Pollution
KW - CYP2A6 protein, human
KW - EC 1.14.14.1
KW - Cytochrome P-450 CYP2A6
KW - Index Medicus
KW - Neoplasm Staging
KW - MicroRNAs -- genetics
KW - Humans
KW - Prognosis
KW - Aged
KW - Child
KW - Receptors, Nicotinic -- genetics
KW - Cytochrome P-450 CYP2A6 -- genetics
KW - Risk Factors
KW - Case-Control Studies
KW - Follow-Up Studies
KW - Middle Aged
KW - 3' Untranslated Regions -- genetics
KW - Female
KW - Male
KW - Lung Neoplasms -- etiology
KW - Receptors, Dopamine D1 -- genetics
KW - Disease Susceptibility
KW - Polymorphism, Genetic -- genetics
KW - Tobacco Smoke Pollution -- adverse effects
KW - Smoking -- genetics
KW - Lung Neoplasms -- pathology
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=A+DRD1+polymorphism+predisposes+to+lung+cancer+among+those+exposed+to+secondhand+smoke+during+childhood.&rft.au=Robles%2C+Ana+I%3BYang%2C+Ping%3BJen%2C+Jin%3BMcClary%2C+Andrew+C%3BCalhoun%2C+Kara%3BBowman%2C+Elise+D%3BV%C3%A4h%C3%A4kangas%2C+Kirsi%3BGreathouse%2C+K+Leigh%3BWang%2C+Yi%3BOlivo-Marston%2C+Susan%3BWenzlaff%2C+Angela+S%3BDeng%2C+Bo%3BSchwartz%2C+Ann+G%3BRyan%2C+Br%C3%ADd+M&rft.aulast=Robles&rft.aufirst=Ana&rft.date=2014-12-01&rft.volume=7&rft.issue=12&rft.spage=1210&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-14-0158
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-30
N1 - Date created - 2014-12-03
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1158/1940-6207.CAPR-14-0158
ER -
TY - JOUR
T1 - Research Resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant.
AN - 1629963814; 25321415
AB - Human ovarian cancer BG-1 cells are a valuable in vitro model that has enabled several laboratories to study the estrogenic responses of ovarian cancers. We recently discovered that there are two different BG-1 cell lines being used for experiments, denoted here as BG-1 FR and BG-1 NIEHS, which exhibit striking morphological differences. The objective of this study was to methodically analyze these two BG-1 variants and compare their characteristics. Short tandem repeat analysis revealed that the DNA profile of BG-1 FR cells was unique, yet the Short tandem repeat pattern of BG-1 NIEHS was identical with that of MCF-7 cells. From a cytogenetic analysis, it became apparent that the BG-1 FR line had the same profile as previously reported, whereas the BG-1 NIEHS and MCF-7 cells share a similar genetic display. A significant number of unique chromosomal translocations were observed between the BG-1 NIEHS and MCF-7 cells, suggesting that acquired genotypic differences resulted in the formation of two lines from a common origin. Although all cell types demonstrated a similar estrogen responsiveness in reporter gene assays, a microarray analysis revealed distinct estrogen-responsive gene expression patterns with surprisingly moderate to low overlap. We conclude that BG-1 FR is the original ovarian cancer cell line, whereas the BG-1 NIEHS is a variant from the MCF-7 cells. These findings provide much needed clarification of the identities and characteristics of key cell line models that are widely used to study estrogen action in female reproductive cancers.
JF - Molecular endocrinology (Baltimore, Md.)
AU - Li, Yin
AU - Arao, Yukitomo
AU - Hall, Julie M
AU - Burkett, Sandra
AU - Liu, Liwen
AU - Gerrish, Kevin
AU - Cavailles, Vincent
AU - Korach, Kenneth S
AD - Laboratory of Reproductive and Developmental Toxicology (Y.L., Y.A., K.S.K.) and Molecular Genomics Core Facility (L.L., K.G.), National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709; College of Pharmacy and Health Sciences (J.M.H.), Campbell University, Buies Creek, North Carolina 27506; Center for Cancer Research (S.B.), National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702; and Institut de Recherche en Cancérologie de Montpellier (V.C.), Institut de Recherche en Cancerologie de Montpellier and INSERM Unité 896, Universite Montpellier1, F-34298 Montpellier, France.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 2072
EP - 2081
VL - 28
IS - 12
KW - Receptors, Estrogen
KW - 0
KW - DNA
KW - 9007-49-2
KW - Index Medicus
KW - Genotype
KW - Translocation, Genetic -- genetics
KW - Receptors, Estrogen -- genetics
KW - Humans
KW - Cell Line, Tumor
KW - Female
KW - Ovarian Neoplasms -- genetics
KW - DNA -- genetics
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629963814?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Research+Resource%3A+STR+DNA+profile+and+gene+expression+comparisons+of+human+BG-1+cells+and+a+BG-1%2FMCF-7+clonal+variant.&rft.au=Li%2C+Yin%3BArao%2C+Yukitomo%3BHall%2C+Julie+M%3BBurkett%2C+Sandra%3BLiu%2C+Liwen%3BGerrish%2C+Kevin%3BCavailles%2C+Vincent%3BKorach%2C+Kenneth+S&rft.aulast=Li&rft.aufirst=Yin&rft.date=2014-12-01&rft.volume=28&rft.issue=12&rft.spage=2072&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=1944-9917&rft_id=info:doi/10.1210%2Fme.2014-1229
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-01
N1 - Date created - 2014-12-02
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1210/me.2014-1229
ER -
TY - JOUR
T1 - ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.
AN - 1629963582; 25269479
AB - Camptothecin and its derivatives, topotecan and irinotecan, are specific topoisomerase I (Top1) inhibitors and potent anticancer drugs killing cancer cells by producing replication-associated DNA double-strand breaks, and the indenoisoquinoline LMP-400 (indotecan) is a novel Top1 inhibitor in clinical trial. To develop novel drug combinations, we conducted a synthetic lethal siRNA screen using a library that targets nearly 7,000 human genes. Depletion of ATR, the main transducer of replication stress, came as a top candidate gene for camptothecin synthetic lethality. Validation studies using ATR siRNA and the ATR inhibitor VE-821 confirmed marked antiproliferative synergy with camptothecin and even greater synergy with LMP-400. Single-cell analyses and DNA fiber combing assays showed that VE-821 abrogates the S-phase replication elongation checkpoint and the replication origin-firing checkpoint induced by camptothecin and LMP-400. As expected, the combination of Top1 inhibitors with VE-821 inhibited the phosphorylation of ATR and Chk1; however, it strongly induced γH2AX. In cells treated with the combination, the γH2AX pattern changed over time from the well-defined Top1-induced damage foci to an intense peripheral and diffuse nuclear staining, which could be used as response biomarker. Finally, the clinical derivative of VE-821, VX-970, enhanced the in vivo tumor response to irinotecan without additional toxicity. A key implication of our work is the mechanistic rationale and proof of principle it provides to evaluate the combination of Top1 inhibitors with ATR inhibitors in clinical trials.
©2014 American Association for Cancer Research.
JF - Cancer research
AU - Jossé, Rozenn
AU - Martin, Scott E
AU - Guha, Rajarshi
AU - Ormanoglu, Pinar
AU - Pfister, Thomas D
AU - Reaper, Philip M
AU - Barnes, Christopher S
AU - Jones, Julie
AU - Charlton, Peter
AU - Pollard, John R
AU - Morris, Joel
AU - Doroshow, James H
AU - Pommier, Yves
AD - Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. ; Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, Rockville, Maryland. ; Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc, National Laboratory for Cancer Research, Frederick, Maryland. ; Vertex Pharmaceuticals (Europe) Ltd, Abingdon, Oxfordshire, United Kingdom. ; Drug Synthesis and Chemistry Branch, Division of Cancer Treatment, Division of Cancer Treatment and Diagnosis (DTP-DCTD), NCI-NIH, Bethesda, Maryland. ; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. Drug Synthesis and Chemistry Branch, Division of Cancer Treatment, Division of Cancer Treatment and Diagnosis (DTP-DCTD), NCI-NIH, Bethesda, Maryland. ; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. pommier@nih.gov.
Y1 - 2014/12/01/
PY - 2014
DA - 2014 Dec 01
SP - 6968
EP - 6979
VL - 74
IS - 23
KW - 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide
KW - 0
KW - H2AFX protein, human
KW - Histones
KW - Organothiophosphorus Compounds
KW - Pyrazines
KW - Sulfones
KW - Topoisomerase I Inhibitors
KW - irinotecan
KW - 0H43101T0J
KW - Topotecan
KW - 7M7YKX2N15
KW - VX
KW - 9A4381183B
KW - Protein Kinases
KW - EC 2.7.-
KW - ATR protein, human
KW - EC 2.7.11.1
KW - Ataxia Telangiectasia Mutated Proteins
KW - CHEK1 protein, human
KW - Checkpoint Kinase 1
KW - DNA Topoisomerases, Type I
KW - EC 5.99.1.2
KW - TOP1 protein, human
KW - Camptothecin
KW - XT3Z54Z28A
KW - Index Medicus
KW - Camptothecin -- pharmacology
KW - DNA Damage
KW - Humans
KW - Ataxia Telangiectasia Mutated Proteins -- metabolism
KW - Cell Line, Tumor
KW - Ataxia Telangiectasia Mutated Proteins -- antagonists & inhibitors
KW - Phosphorylation -- drug effects
KW - Protein Kinases -- metabolism
KW - Single-Cell Analysis -- methods
KW - Topotecan -- pharmacology
KW - Histones -- metabolism
KW - Protein Kinases -- genetics
KW - Camptothecin -- analogs & derivatives
KW - HT29 Cells
KW - Histones -- genetics
KW - Topoisomerase I Inhibitors -- pharmacology
KW - Sulfones -- pharmacology
KW - Replication Origin -- drug effects
KW - Pyrazines -- pharmacology
KW - Organothiophosphorus Compounds -- pharmacology
KW - DNA Topoisomerases, Type I -- metabolism
KW - DNA Replication -- drug effects
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-03-04
N1 - Date created - 2014-12-02
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1158/0008-5472.CAN-13-3369
ER -
TY - JOUR
T1 - An open-label phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) with bevacizumab in patients with advanced cancer.
AN - 1629961331; 25261556
AB - Endoglin, an endothelial cell membrane receptor expressed on angiogenic tumor vessels, is essential for angiogenesis and upregulated in the setting of VEGF inhibition. TRC105 is an anti-endoglin IgG1 monoclonal antibody that potentiates VEGF inhibitors in preclinical models. This study assessed safety, pharmacokinetics, and antitumor activity of TRC105 in combination with bevacizumab.
Patients (n = 38) with advanced solid tumors, Eastern Cooperative Group performance status 0-1, and normal organ function were treated with escalating doses of TRC105 plus bevacizumab until disease progression or unacceptable toxicity using a standard 3 + 3 phase I design. TRC105 and bevacizumab were well tolerated at their recommended single-agent doses (10 mg/kg) when the initial dose of TRC105 was delayed by one week and divided over 2 days to limit the frequency of headache. The concurrent administration of bevacizumab and TRC105 did not otherwise potentiate known toxicities of TRC105 or bevacizumab. Hypertension and proteinuria were observed, though not at rates expected for single-agent bevacizumab. Several patients who had previously progressed on bevacizumab or VEGF receptor tyrosine kinase inhibitor (VEGFR TKI) treatment experienced reductions in tumor volume, including two partial responses by RECIST, and 6 remained without progression for longer periods than during their prior VEGF inhibitor therapy.
TRC105 was well tolerated with bevacizumab and clinical activity was observed in a VEGF inhibitor-refractory population. Ongoing clinical trials are testing TRC105 in combination with bevacizumab in glioblastoma and with VEGFR TKIs in renal cell carcinoma, hepatocellular carcinoma, and soft tissue sarcoma. ©2014 American Association for Cancer Research.
JF - Clinical cancer research : an official journal of the American Association for Cancer Research
AU - Gordon, Michael S
AU - Robert, Francisco
AU - Matei, Daniela
AU - Mendelson, David S
AU - Goldman, Jonathan W
AU - Chiorean, E Gabriela
AU - Strother, Robert M
AU - Seon, Ben K
AU - Figg, William D
AU - Peer, Cody J
AU - Alvarez, Delia
AU - Adams, Bonne J
AU - Theuer, Charles P
AU - Rosen, Lee S
AD - Pinnacle Oncology Hematology, Scottsdale, Arizona. mgordon@azpoh.com. ; University of Alabama, Birmingham, Alabama. ; Indiana University School of Medicine, Indianapolis, Indiana. ; Pinnacle Oncology Hematology, Scottsdale, Arizona. ; UCLA Department of Medicine, Los Angeles, California. ; Indiana University School of Medicine, Indianapolis, Indiana. University of Washington, Seattle, Washington. ; Roswell Park Cancer Institute, Buffalo, New York. ; Clinical Pharmacology Program, National Cancer Institute, Bethesda, Maryland. ; TRACON Pharmaceuticals, San Diego, California.
Y1 - 2014/12/01/
PY - 2014
DA - 2014 Dec 01
SP - 5918
EP - 5926
VL - 20
IS - 23
SN - 1078-0432, 1078-0432
KW - Antibodies, Monoclonal
KW - 0
KW - Antibodies, Monoclonal, Humanized
KW - TRC105
KW - Bevacizumab
KW - 2S9ZZM9Q9V
KW - Index Medicus
KW - Antibodies, Monoclonal, Humanized -- pharmacokinetics
KW - Neoplasm Staging
KW - Antibodies, Monoclonal -- pharmacokinetics
KW - Aged, 80 and over
KW - Humans
KW - Adult
KW - Treatment Outcome
KW - Aged
KW - Middle Aged
KW - Maximum Tolerated Dose
KW - Antibodies, Monoclonal, Humanized -- administration & dosage
KW - Male
KW - Female
KW - Antibodies, Monoclonal -- administration & dosage
KW - Neoplasms -- drug therapy
KW - Neoplasms -- diagnosis
KW - Neoplasms -- pathology
KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects
KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629961331?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=An+open-label+phase+Ib+dose-escalation+study+of+TRC105+%28anti-endoglin+antibody%29+with+bevacizumab+in+patients+with+advanced+cancer.&rft.au=Gordon%2C+Michael+S%3BRobert%2C+Francisco%3BMatei%2C+Daniela%3BMendelson%2C+David+S%3BGoldman%2C+Jonathan+W%3BChiorean%2C+E+Gabriela%3BStrother%2C+Robert+M%3BSeon%2C+Ben+K%3BFigg%2C+William+D%3BPeer%2C+Cody+J%3BAlvarez%2C+Delia%3BAdams%2C+Bonne+J%3BTheuer%2C+Charles+P%3BRosen%2C+Lee+S&rft.aulast=Gordon&rft.aufirst=Michael&rft.date=2014-12-01&rft.volume=20&rft.issue=23&rft.spage=5918&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-1143
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-28
N1 - Date created - 2014-12-02
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Clin Cancer Res. 2008 Apr 1;14(7):1931-7 [18381930]
Curr Oncol Rep. 2014 Feb;16(2):365 [24445497]
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Gynecol Oncol. 2009 Mar;112(3):469-74 [19135712]
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Bull Cancer. 2000 Dec;87(12):881-6 [11174117]
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Neuropathology. 2005 Sep;25(3):201-6 [16193836]
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N Engl J Med. 2008 Jul 24;359(4):378-90 [18650514]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-1143
ER -
TY - JOUR
T1 - A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.
AN - 1629588824; 25242567
AB - Chemotherapy-induced peripheral neuropathy accompanied by chronic neuropathic pain is the major dose-limiting toxicity of several anticancer agents including the taxane paclitaxel (Taxol). A critical mechanism underlying paclitaxel-induced neuropathic pain is the increased production of peroxynitrite in spinal cord generated in response to activation of the superoxide-generating enzyme, NADPH oxidase. Peroxynitrite in turn contributes to the development of neuropathic pain by modulating several redox-dependent events in spinal cord. We recently reported that activation of the Gi/Gq-coupled A3 adenosine receptor (A3AR) with selective A3AR agonists (ie, IB-MECA) blocked the development of chemotherapy induced-neuropathic pain evoked by distinct agents, including paclitaxel, without interfering with anticancer effects. The mechanism or mechanisms of action underlying these beneficial effects has yet to be explored. We now demonstrate that IB-MECA attenuates the development of paclitaxel-induced neuropathic pain by inhibiting the activation of spinal NADPH oxidase and two downstream redox-dependent systems. The first relies on inhibition of the redox-sensitive transcription factor (NFκB) and mitogen activated protein kinases (ERK and p38) resulting in decreased production of neuroexcitatory/proinflammatory cytokines (TNF-α, IL-1β) and increased formation of the neuroprotective/anti-inflammatory IL-10. The second involves inhibition of redox-mediated posttranslational tyrosine nitration and modification (inactivation) of glia-restricted proteins known to play key roles in regulating synaptic glutamate homeostasis: the glutamate transporter GLT-1 and glutamine synthetase. Our results unravel a mechanistic link into biomolecular signaling pathways employed by A3AR activation in neuropathic pain while providing the foundation to consider use of A3AR agonists as therapeutic agents in patients with chemotherapy-induced peripheral neuropathy. Copyright © 2014 International Association for the Study of Pain. All rights reserved.
JF - Pain
AU - Janes, Kali
AU - Esposito, Emanuela
AU - Doyle, Timothy
AU - Cuzzocrea, Salvatore
AU - Tosh, Dillip K
AU - Jacobson, Kenneth A
AU - Salvemini, Daniela
AD - Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA. ; Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina 98122, Italy. ; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, USA. ; Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA. Electronic address: salvemd@slu.edu.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 2560
EP - 2567
VL - 155
IS - 12
KW - Adenosine A3 Receptor Agonists
KW - 0
KW - Antineoplastic Agents, Phytogenic
KW - Cytokines
KW - Excitatory Amino Acid Transporter 2
KW - NF-kappa B
KW - Slc1a2 protein, rat
KW - Tumor Necrosis Factor-alpha
KW - N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine
KW - 152918-18-8
KW - NADP
KW - 53-59-8
KW - Adenosine
KW - K72T3FS567
KW - Paclitaxel
KW - P88XT4IS4D
KW - Index Medicus
KW - Neuropathic pain
KW - A3
KW - Spinal cord
KW - Neuroinflammation
KW - Chemotherapy-induced peripheral neuropathy
KW - Excitatory Amino Acid Transporter 2 -- metabolism
KW - Animals
KW - Hyperalgesia -- etiology
KW - Adenosine -- analogs & derivatives
KW - Disease Models, Animal
KW - NADP -- metabolism
KW - Cytokines -- metabolism
KW - Adenosine -- therapeutic use
KW - Rats
KW - Oxidation-Reduction
KW - Neuroglia -- metabolism
KW - Rats, Sprague-Dawley
KW - Antineoplastic Agents, Phytogenic -- toxicity
KW - Paclitaxel -- toxicity
KW - Excitatory Amino Acid Transporter 2 -- genetics
KW - Male
KW - Neuralgia -- physiopathology
KW - Spinal Cord -- metabolism
KW - Adenosine A3 Receptor Agonists -- therapeutic use
KW - Signal Transduction -- drug effects
KW - Spinal Cord -- pathology
KW - Neuralgia -- chemically induced
KW - Neuralgia -- pathology
KW - Neuralgia -- prevention & control
KW - NF-kappa B -- metabolism
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629588824?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain&rft.atitle=A3+adenosine+receptor+agonist+prevents+the+development+of+paclitaxel-induced+neuropathic+pain+by+modulating+spinal+glial-restricted+redox-dependent+signaling+pathways.&rft.au=Janes%2C+Kali%3BEsposito%2C+Emanuela%3BDoyle%2C+Timothy%3BCuzzocrea%2C+Salvatore%3BTosh%2C+Dillip+K%3BJacobson%2C+Kenneth+A%3BSalvemini%2C+Daniela&rft.aulast=Janes&rft.aufirst=Kali&rft.date=2014-12-01&rft.volume=155&rft.issue=12&rft.spage=2560&rft.isbn=&rft.btitle=&rft.title=Pain&rft.issn=1872-6623&rft_id=info:doi/10.1016%2Fj.pain.2014.09.016
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-15
N1 - Date created - 2014-12-01
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.pain.2014.09.016
ER -
TY - JOUR
T1 - Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways.
AN - 1629588671; 25153034
AB - Nitric oxide (NO) synthase 2 (NOS2), a major inflammatory protein, modulates disease progression via NO in a number of pathologies, including cancer. The role of NOS2-derived NO is not only flux-dependent, which is higher in mouse vs human cells, but also varies based on spatial and temporal distribution both within tumor cells and in the tumor microenvironment. NO donors have been utilized to mimic NO flux conditions and to investigate the effects of varied NO concentrations. As a wide range of effects mediated by NO and other nitrogen oxides such as nitroxyl (HNO) have been elucidated, multiple NO- and HNO-releasing compounds have been developed as potential therapeutics, including as tumor modulators. One of the challenges is to determine differences in biomarker expression from extracellular vs intracellular generation of NO or HNO. Taking advantage of new NO and HNO releasing agents, we have characterized the gene expression profile of estrogen receptor-negative human breast cancer (MDA-MB-231) cells following exposure to aspirin, the NO donor DEA/NO, the HNO donor IPA/NO andtheir intracellularly-activated prodrug conjugates DEA/NO-aspirin and IPA/NO-aspirin. Comparison of the gene expression profiles demonstrated that several genes were uniquely expressed with respect to NO or HNO, such as miR-21, HSP70, cystathionine γ-lyase and IL24. These findings provide insight into targets and pathways that could be therapeutically exploited by the redox related species NO and HNO.
Published by Elsevier Inc.
JF - Nitric oxide : biology and chemistry
AU - Cheng, Robert Y S
AU - Basudhar, Debashree
AU - Ridnour, Lisa A
AU - Heinecke, Julie L
AU - Kesarwala, Aparna H
AU - Glynn, Sharon
AU - Switzer, Christopher H
AU - Ambs, Stefan
AU - Miranda, Katrina M
AU - Wink, David A
AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address: robert.cheng2@nih.gov. ; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA. ; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. ; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. ; Prostate Cancer Institute, NUI Galway, Ireland. ; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. ; Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA.
Y1 - 2014/12/01/
PY - 2014
DA - 2014 Dec 01
SP - 17
EP - 28
VL - 43
KW - Nitric Oxide Donors
KW - 0
KW - Nitric Oxide
KW - 31C4KY9ESH
KW - Nitric Oxide Synthase
KW - EC 1.14.13.39
KW - Index Medicus
KW - Nitroxyl
KW - Cell signaling
KW - Cancer biology
KW - Breast cancer
KW - Nitric oxide synthase
KW - Nitric oxide
KW - Breast Neoplasms -- genetics
KW - Gene Expression Profiling
KW - Animals
KW - Humans
KW - Breast Neoplasms -- therapy
KW - Mice
KW - Cell Line, Tumor
KW - Nitric Oxide Synthase -- metabolism
KW - Signal Transduction
KW - Female
KW - Drug Resistance, Neoplasm -- drug effects
KW - Nitric Oxide Donors -- pharmacology
KW - Nitric Oxide -- pharmacology
KW - Gene Expression Regulation, Neoplastic -- drug effects
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629588671?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nitric+oxide+%3A+biology+and+chemistry&rft.atitle=Gene+expression+profiles+of+NO-+and+HNO-donor+treated+breast+cancer+cells%3A+insights+into+tumor+response+and+resistance+pathways.&rft.au=Cheng%2C+Robert+Y+S%3BBasudhar%2C+Debashree%3BRidnour%2C+Lisa+A%3BHeinecke%2C+Julie+L%3BKesarwala%2C+Aparna+H%3BGlynn%2C+Sharon%3BSwitzer%2C+Christopher+H%3BAmbs%2C+Stefan%3BMiranda%2C+Katrina+M%3BWink%2C+David+A&rft.aulast=Cheng&rft.aufirst=Robert+Y&rft.date=2014-12-01&rft.volume=43&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Nitric+oxide+%3A+biology+and+chemistry&rft.issn=1089-8611&rft_id=info:doi/10.1016%2Fj.niox.2014.08.003
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-09-01
N1 - Date created - 2014-12-01
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Nitric Oxide. 2013 Apr 1;30:26-35 [23357401]
Prostate. 2013 Jun;73(9):932-40 [23334979]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.niox.2014.08.003
ER -
TY - JOUR
T1 - Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A.
AN - 1629586167; 25233928
AB - Pancreatic ductal adenocarcinoma (PDAC) is driven by the accumulation of somatic mutations, epigenetic modifications and changes in the micro-environment. New approaches to investigating disruptions of gene expression networks promise to uncover key regulators and pathways in carcinogenesis. We performed messenger RNA-sequencing in pancreatic normal (n = 10) and tumor (n = 8) derived tissue samples, as well as in pancreatic cancer cell lines (n = 9), to determine differential gene expression (DE) patterns. Sub-network enrichment analyses identified HNF1A as the regulator of the most significantly and consistently dysregulated expression sub-network in pancreatic tumor tissues and cells (median P = 7.56×10(-7), median rank = 1, range = 1-25). To explore the effects of HNF1A expression in pancreatic tumor-derived cells, we generated stable HNF1A-inducible clones in two pancreatic cancer cell lines (PANC-1 and MIA PaCa-2) and observed growth inhibition (5.3-fold, P = 4.5×10(-5) for MIA PaCa-2 clones; 7.2-fold, P = 2.2×10(-5) for PANC-1 clones), and a G0/G1 cell cycle arrest and apoptosis upon induction. These effects correlated with HNF1A-induced down-regulation of 51 of 84 cell cycle genes (e.g. E2F1, CDK2, CDK4, MCM2/3/4/5, SKP2 and CCND1), decreased expression of anti-apoptotic genes (e.g. BIRC2/5/6 and AKT) and increased expression of pro-apoptotic genes (e.g. CASP4/9/10 and APAF1). In light of the established role of HNF1A in the regulation of pancreatic development and homeostasis, our data suggest that it also functions as an important tumor suppressor in the pancreas.
Published by Oxford University Press 2014.
JF - Carcinogenesis
AU - Hoskins, Jason W
AU - Jia, Jinping
AU - Flandez, Marta
AU - Parikh, Hemang
AU - Xiao, Wenming
AU - Collins, Irene
AU - Emmanuel, Mickey A
AU - Ibrahim, Abdisamad
AU - Powell, John
AU - Zhang, Lizhi
AU - Malats, Nuria
AU - Bamlet, William R
AU - Petersen, Gloria M
AU - Real, Francisco X
AU - Amundadottir, Laufey T
AD - Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, E-28029 Madrid, Spain, Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute and Bioinformatics and Molecular Analysis Section, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA, Department of Laboratory Medicine and Pathology and Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain. ; Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, E-28029 Madrid, Spain. ; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute and. ; Bioinformatics and Molecular Analysis Section, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA. ; Department of Laboratory Medicine and Pathology and. ; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA and. ; Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, E-28029 Madrid, Spain, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain. ; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, E-28029 Madrid, Spain, Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute and Bioinformatics and Molecular Analysis Section, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA, Department of Laboratory Medicine and Pathology and Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain amundadottirl@mail.nih.gov.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 2670
EP - 2678
VL - 35
IS - 12
KW - Biomarkers, Tumor
KW - 0
KW - HNF1A protein, human
KW - Hepatocyte Nuclear Factor 1-alpha
KW - RNA, Messenger
KW - Index Medicus
KW - Real-Time Polymerase Chain Reaction
KW - Apoptosis
KW - Humans
KW - Gene Regulatory Networks
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Cell Proliferation
KW - RNA, Messenger -- genetics
KW - Blotting, Western
KW - Cells, Cultured
KW - Pancreas -- metabolism
KW - Flow Cytometry
KW - Cell Cycle
KW - Immunoenzyme Techniques
KW - Biomarkers, Tumor -- metabolism
KW - Gene Expression Profiling
KW - Biomarkers, Tumor -- genetics
KW - Pancreatic Neoplasms -- pathology
KW - Pancreatic Neoplasms -- metabolism
KW - Hepatocyte Nuclear Factor 1-alpha -- genetics
KW - Hepatocyte Nuclear Factor 1-alpha -- metabolism
KW - Genes, Tumor Suppressor
KW - Carcinoma, Pancreatic Ductal -- metabolism
KW - Carcinoma, Pancreatic Ductal -- pathology
KW - Carcinoma, Pancreatic Ductal -- genetics
KW - Pancreatic Neoplasms -- genetics
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Transcriptome+analysis+of+pancreatic+cancer+reveals+a+tumor+suppressor+function+for+HNF1A.&rft.au=Hoskins%2C+Jason+W%3BJia%2C+Jinping%3BFlandez%2C+Marta%3BParikh%2C+Hemang%3BXiao%2C+Wenming%3BCollins%2C+Irene%3BEmmanuel%2C+Mickey+A%3BIbrahim%2C+Abdisamad%3BPowell%2C+John%3BZhang%2C+Lizhi%3BMalats%2C+Nuria%3BBamlet%2C+William+R%3BPetersen%2C+Gloria+M%3BReal%2C+Francisco+X%3BAmundadottir%2C+Laufey+T&rft.aulast=Hoskins&rft.aufirst=Jason&rft.date=2014-12-01&rft.volume=35&rft.issue=12&rft.spage=2670&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgu193
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-14
N1 - Date created - 2014-12-01
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/carcin/bgu193
ER -
TY - JOUR
T1 - Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression.
AN - 1629586076; 25280562
AB - Sporadic and non-hereditary mutations account for the majority of colorectal cancers (CRC). After the loss of adenomatous polyposis coli (APC) function and activation of the β-catenin/LEF signaling pathway, activating mutations in Kras are major drivers of sporadic CRC. Preventing the outgrowth of cells that develop sporadic mutations will decrease CRC. Resveratrol, a naturally occurring polyphenolic compound has anti-inflammatory, anti-oxidant and anti-cancer activities. We used a genetically engineered mouse model for sporadic CRC where the APC locus is knocked out and Kras is activated specifically in the distal colon to determine the effects of resveratrol on preventing and treating CRC. Feeding mice a diet supplemented with 150 or 300 ppm resveratrol (105 and 210mg daily human equivalent dose, respectively) before tumors were visible by colonoscopy resulted in a 60% inhibition of tumor production. In the 40% of mice that did develop tumors Kras expression was lost in the tumors. In a therapeutic assay where tumors were allowed to develop prior to treatment, feeding tumor bearing mice with resveratrol resulted in a complete remission in 33% of the mice and a 97% decrease in tumor size in the remaining mice. Analysis of miRNA expression in non-tumoral and tumoral colonic tissue of resveratrol treated mice showed an increased expression of miR-96, a miRNA previously shown to regulate Kras translation. These data indicate that resveratrol can prevent the formation and growth of colorectal tumors by downregulating Kras expression.
Published by Oxford University Press 2014.
JF - Carcinogenesis
AU - Saud, Shakir M
AU - Li, Weidong
AU - Morris, Nicole L
AU - Matter, Matthias S
AU - Colburn, Nancy H
AU - Kim, Young S
AU - Young, Matthew R
AD - Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA. ; Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA, Oncology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ; Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick, MD, USA and. ; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. ; Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA. ; Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA. ; Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA, youngma@mail.nih.gov.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 2778
EP - 2786
VL - 35
IS - 12
KW - Adenomatous Polyposis Coli Protein
KW - 0
KW - Anticarcinogenic Agents
KW - RNA, Messenger
KW - Stilbenes
KW - Kras2 protein, mouse
KW - EC 3.6.5.2
KW - Proto-Oncogene Proteins p21(ras)
KW - resveratrol
KW - Q369O8926L
KW - Index Medicus
KW - Real-Time Polymerase Chain Reaction
KW - Cell Proliferation -- drug effects
KW - Animals
KW - Humans
KW - Disease Models, Animal
KW - Mice
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - RNA, Messenger -- genetics
KW - Mice, Knockout
KW - Blotting, Western
KW - Tumor Cells, Cultured
KW - Mutation -- genetics
KW - Female
KW - Immunoenzyme Techniques
KW - Male
KW - Cell Transformation, Neoplastic -- pathology
KW - Anticarcinogenic Agents -- therapeutic use
KW - Colorectal Neoplasms -- pathology
KW - Stilbenes -- therapeutic use
KW - Colorectal Neoplasms -- etiology
KW - Cell Transformation, Neoplastic -- drug effects
KW - Proto-Oncogene Proteins p21(ras) -- antagonists & inhibitors
KW - Adenomatous Polyposis Coli Protein -- physiology
KW - Colorectal Neoplasms -- prevention & control
KW - Cell Transformation, Neoplastic -- genetics
KW - Proto-Oncogene Proteins p21(ras) -- genetics
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Resveratrol+prevents+tumorigenesis+in+mouse+model+of+Kras+activated+sporadic+colorectal+cancer+by+suppressing+oncogenic+Kras+expression.&rft.au=Saud%2C+Shakir+M%3BLi%2C+Weidong%3BMorris%2C+Nicole+L%3BMatter%2C+Matthias+S%3BColburn%2C+Nancy+H%3BKim%2C+Young+S%3BYoung%2C+Matthew+R&rft.aulast=Saud&rft.aufirst=Shakir&rft.date=2014-12-01&rft.volume=35&rft.issue=12&rft.spage=2778&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgu209
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-14
N1 - Date created - 2014-12-01
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/carcin/bgu209
ER -
TY - JOUR
T1 - Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers.
AN - 1629585949; 25239644
AB - The chromosome 9p21 region has been implicated in the pathogenesis of multiple cancers. We analyzed 9p21 single nucleotide polymorphisms (SNPs) from eight genome-wide association studies (GWAS) with data deposited in dbGaP, including studies of esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), pancreatic cancer, renal cell carcinoma (RCC), lung cancer (LC), breast cancer (BrC), bladder cancer (BC) and prostate cancer (PrC). The number of subjects ranged from 2252 (PrC) to 7619 (LC). SNP-level analyses for each cancer were conducted by logistic regression or random-effects meta-analysis. A subset-based statistical approach (ASSET) was performed to combine SNP-level P values across multiple cancers. We calculated gene-level P values using the adaptive rank truncated product method. We identified that rs1063192 and rs2157719 in the CDKN2A/2B region were significantly associated with ESCC and rs2764736 (3' of TUSC1) was associated with BC (P ≤ 2.59 × 10(-6)). ASSET analyses identified four SNPs significantly associated with multiple cancers: rs3731239 (CDKN2A intronic) with ESCC, GC and BC (P = 3.96 × 10(-) (4)); rs10811474 (3' of IFNW1) with RCC and BrC (P = 0.001); rs12683422 (LINGO2 intronic) with RCC and BC (P = 5.93 × 10(-) (4)) and rs10511729 (3' of ELAVL2) with LC and BrC (P = 8.63 × 10(-) (4)). At gene level, CDKN2B, CDKN2A and CDKN2B-AS1 were significantly associated with ESCC (P ≤ 4.70 × 10(-) (5)). Rs10511729 and rs10811474 were associated with cis-expression of 9p21 genes in corresponding cancer tissues in the expression quantitative trait loci analysis. In conclusion, we identified several genetic variants in the 9p21 region associated with the risk of multiple cancers, suggesting that this region may contribute to a shared susceptibility across different cancer types. Published by Oxford University Press 2014.
JF - Carcinogenesis
AU - Li, Wen-Qing
AU - Pfeiffer, Ruth M
AU - Hyland, Paula L
AU - Shi, Jianxin
AU - Gu, Fangyi
AU - Wang, Zhaoming
AU - Bhattacharjee, Samsiddhi
AU - Luo, Jun
AU - Xiong, Xiaoqin
AU - Yeager, Meredith
AU - Deng, Xiang
AU - Hu, Nan
AU - Taylor, Philip R
AU - Albanes, Demetrius
AU - Caporaso, Neil E
AU - Gapstur, Susan M
AU - Amundadottir, Laufey
AU - Chanock, Stephen J
AU - Chatterjee, Nilanjan
AU - Landi, Maria Teresa
AU - Tucker, Margaret A
AU - Goldstein, Alisa M
AU - Yang, Xiaohong R
AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA, Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, USA, wen-qing_li@brown.edu. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA, Cancer Genomics Research Laboratory, NCI-Frederick, SAIC-Frederick Inc., Frederick, MD, USA. ; National Institute of Biomedical Genomics, Kalyani, India. ; Information Management Services, Inc., Calverton, MD, USA and. ; Information Management Services, Inc., Calverton, MD, USA and wen-qing_li@brown.edu royang@mail.nih.gov. ; Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 2698
EP - 2705
VL - 35
IS - 12
KW - Biomarkers, Tumor
KW - 0
KW - Index Medicus
KW - Genotype
KW - Polymerase Chain Reaction
KW - Risk Factors
KW - Humans
KW - Prognosis
KW - Genome-Wide Association Study
KW - Biomarkers, Tumor -- genetics
KW - Quantitative Trait Loci
KW - Genetic Predisposition to Disease
KW - Polymorphism, Single Nucleotide -- genetics
KW - Neoplasms -- genetics
KW - Chromosomes, Human, Pair 9 -- genetics
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629585949?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Genetic+polymorphisms+in+the+9p21+region+associated+with+risk+of+multiple+cancers.&rft.au=Li%2C+Wen-Qing%3BPfeiffer%2C+Ruth+M%3BHyland%2C+Paula+L%3BShi%2C+Jianxin%3BGu%2C+Fangyi%3BWang%2C+Zhaoming%3BBhattacharjee%2C+Samsiddhi%3BLuo%2C+Jun%3BXiong%2C+Xiaoqin%3BYeager%2C+Meredith%3BDeng%2C+Xiang%3BHu%2C+Nan%3BTaylor%2C+Philip+R%3BAlbanes%2C+Demetrius%3BCaporaso%2C+Neil+E%3BGapstur%2C+Susan+M%3BAmundadottir%2C+Laufey%3BChanock%2C+Stephen+J%3BChatterjee%2C+Nilanjan%3BLandi%2C+Maria+Teresa%3BTucker%2C+Margaret+A%3BGoldstein%2C+Alisa+M%3BYang%2C+Xiaohong+R&rft.aulast=Li&rft.aufirst=Wen-Qing&rft.date=2014-12-01&rft.volume=35&rft.issue=12&rft.spage=2698&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgu203
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-14
N1 - Date created - 2014-12-01
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/carcin/bgu203
ER -
TY - JOUR
T1 - Comparative uterotrophic effects of endoxifen and tamoxifen in ovariectomized Sprague-Dawley rats.
AN - 1628528403; 24670817
AB - Endoxifen (4-hydroxy-N-desmethyl-tamoxifen), one of the major active metabolites of tamoxifen, has substantially greater estrogen antagonist properties and antiproliferative effects in breast tumor cells than tamoxifen, a mixed estrogen agonist/antagonist. An associated risk of endometrial cancer and hyperplasia has been linked to the estrogen agonist properties of tamoxifen. We evaluated endoxifen using a classic uterotrophic effects method. Rats were given endoxifen or tamoxifen orally for 3 days. Estradiol was the positive control. Endoxifen and tamoxifen plasma levels exceeded those previously observed clinically. Uterine weight was 3-fold higher in the estradiol group than in the tamoxifen or endoxifen groups, which did not differ from vehicle controls. Tamoxifen and endoxifen caused a greater increase in luminal epithelial cell height than estradiol. Both tamoxifen and endoxifen produced an increase in the stromal BrdU labeling index (LI) that was ≤ estradiol and inversely related to dose, but did not affect luminal epithelial cell BrdU LI. As expected, estradiol increased luminal epithelial cell proliferation. These results indicate that endoxifen induces uterotrophic effects, but is less potent than estradiol in eliciting these effects. Given prior preclinical observations that endoxifen has superior antitumor activity than tamoxifen, the observations of similar uterine effects suggest that the endoxifen risk/benefit ratio may be superior to tamoxifen.
© 2014 by The Author(s).
JF - Toxicologic pathology
AU - Schweikart, Karen M
AU - Eldridge, Sandy R
AU - Safgren, Stephanie L
AU - Parman, Toufan
AU - Reid, Joel M
AU - Ames, Matthew M
AU - Goetz, Matthew P
AU - Davis, Myrtle A
AD - Developmental Therapeutics Program, National Cancer Institute, Bethesda, Maryland, USA schweikk@mail.nih.gov. ; Charles River Laboratories Pathology Associates, Frederick, Maryland, USA Present address: Developmental Therapeutics Program, National Cancer Institute, Bethesda, MD, USA. ; Mayo Clinic, Rochester, Minnesota, USA. ; SRI International, Menlo Park, California, USA. ; Developmental Therapeutics Program, National Cancer Institute, Bethesda, Maryland, USA.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 1188
EP - 1196
VL - 42
IS - 8
KW - Tamoxifen
KW - 094ZI81Y45
KW - 4-hydroxy-N-desmethyltamoxifen
KW - 110025-28-0
KW - Index Medicus
KW - tamoxifen
KW - endoxifen
KW - endometrial cell proliferation.
KW - Rats
KW - Cell Proliferation -- drug effects
KW - Animals
KW - Rats, Sprague-Dawley
KW - Endometrium -- drug effects
KW - Endometrium -- chemistry
KW - Hypertrophy -- chemically induced
KW - Histocytochemistry
KW - Female
KW - Organ Size -- drug effects
KW - Tamoxifen -- toxicity
KW - Uterus -- chemistry
KW - Ovariectomy
KW - Uterus -- drug effects
KW - Tamoxifen -- analogs & derivatives
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1628528403?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Comparative+uterotrophic+effects+of+endoxifen+and+tamoxifen+in+ovariectomized+Sprague-Dawley+rats.&rft.au=Schweikart%2C+Karen+M%3BEldridge%2C+Sandy+R%3BSafgren%2C+Stephanie+L%3BParman%2C+Toufan%3BReid%2C+Joel+M%3BAmes%2C+Matthew+M%3BGoetz%2C+Matthew+P%3BDavis%2C+Myrtle+A&rft.aulast=Schweikart&rft.aufirst=Karen&rft.date=2014-12-01&rft.volume=42&rft.issue=8&rft.spage=1188&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623314525688
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-08-11
N1 - Date created - 2014-11-26
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Environ Health Perspect. 2001 Aug;109(8):785-94 [11564613]
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J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):245-53 [12798184]
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J Natl Cancer Inst. 2003 Dec 3;95(23):1758-64 [14652237]
Breast Cancer Res Treat. 2004 May;85(2):151-9 [15111773]
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Carcinogenesis. 1990 Dec;11(12):2245-51 [2265476]
Drug Metab Dispos. 1991 Jan-Feb;19(1):36-43 [1673419]
J Natl Cancer Inst. 1993 Nov 17;85(22):1850-5 [8230266]
Carcinogenesis. 1994 Apr;15(4):589-93 [8149466]
Eur J Clin Pharmacol. 1996;51(1):73-8 [8880055]
Fundam Appl Toxicol. 1996 Oct;33(2):182-95 [8921337]
Fundam Appl Toxicol. 1996 Dec;34(2):288-305 [8954758]
Toxicol Sci. 1999 Apr;48(2):197-205 [10353311]
J Natl Cancer Inst. 1999 Oct 6;91(19):1654-62 [10511593]
J Natl Cancer Inst. 2005 Jan 5;97(1):30-9 [15632378]
J Pharmacol Exp Ther. 2006 Aug;318(2):503-12 [16690721]
Breast Cancer Res Treat. 2007 Jan;101(1):113-21 [17115111]
Cancer Res. 2009 Mar 1;69(5):1722-7 [19244106]
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BMJ. 2010;340:c693 [20142325]
Breast Cancer Res Treat. 2010 Jul;122(2):579-84 [20052538]
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Breast Cancer Res. 2011;13(2):R27 [21392396]
Cancer Treat Rev. 2012 Jun;38(4):318-28 [21775065]
Clin Cancer Res. 2013 Jan 15;19(2):500-7 [23213055]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1177/0192623314525688
ER -
TY - JOUR
T1 - Regulatory Forum opinion piece: New testing paradigms for reproductive and developmental toxicity--the NTP modified one generation study and OECD 443.
AN - 1628528352; 24862797
AB - The National Toxicology Program (NTP) has developed a new flexible study design, termed the modified one generation (MOG) reproduction study. The MOG study will encompass measurements of developmental and reproductive toxicity parameters as well as enable the setting of appropriate dose levels for a cancer bioassay through evaluation of target organ toxicity that is based on test article exposure that starts during gestation. This study design is compared and contrasted with the new Organization for Economic Co-operation and Development (OECD) 443 test guideline, the extended one generation reproduction study. The MOG study has a number of advantages, with a focus on F 1 animals, the generation of adequately powered, robust data sets that include both pre and postnatal developmental toxicity information, and the measurement of effects on reproductive structure and function in the same animals. This new study design does not employ the use of internal triggers in the design structure for the use of animals already on test and is also consistent with the principles of the 3R's.
© 2014 by The Author(s).
JF - Toxicologic pathology
AU - Foster, Paul M D
AD - Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA foster2@niehs.nih.gov.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 1165
EP - 1167
VL - 42
IS - 8
KW - Endocrine Disruptors
KW - 0
KW - Index Medicus
KW - female reproduction
KW - male reproduction
KW - reproductive system
KW - safety assessment.
KW - endocrine disrupters
KW - developmental pathology
KW - Endocrine Disruptors -- toxicity
KW - Animals
KW - Humans
KW - Mice
KW - Growth and Development -- drug effects
KW - Reproduction -- drug effects
KW - Toxicity Tests -- methods
KW - Organisation for Economic Co-Operation and Development
KW - Toxicity Tests -- standards
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1628528352?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Regulatory+Forum+opinion+piece%3A+New+testing+paradigms+for+reproductive+and+developmental+toxicity--the+NTP+modified+one+generation+study+and+OECD+443.&rft.au=Foster%2C+Paul+M+D&rft.aulast=Foster&rft.aufirst=Paul+M&rft.date=2014-12-01&rft.volume=42&rft.issue=8&rft.spage=1165&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623314534920
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-08-11
N1 - Date created - 2014-11-26
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Crit Rev Toxicol. 2006 Jan;36(1):69-98 [16708695]
Toxicol Sci. 2010 Aug;116(2):640-6 [20484383]
Environ Health Perspect. 2007 Sep;115(9):1351-6 [17805427]
Toxicol Pathol. 2006;34(6):802-5 [17162538]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1177/0192623314534920
ER -
TY - JOUR
T1 - Perceived and objective diet quality in US adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES)
AN - 1627977482; 20913351
AB - The Dietary Approaches to Stop Hypertension (DASH) dietary pattern has been shown to reduce cardiometabolic risk. Little is understood about the relationship between objective diet quality and perceived diet quality (PDQ), a potential psychosocial barrier to appropriate dietary intake. We compared PDQ and diet quality measured by a nutrient-based DASH index score in the USA. Cross-sectional study. Participants in the 2005-2006 National Health and Nutrition Examination Survey (NHANES) rated diet quality on a 5-point Likert scale and PDQ scores were generated (low, medium, high). A single 24 h dietary recall was used to estimate DASH index scores (range 0-9 points) by assigning 0, 0.5 or 1 point (optimal) for nine target nutrients: total fat, saturated fat, protein, cholesterol, fibre, Ca, Mg, K and Na. Nationally representative sample of the US population. Adults aged greater than or equal to 19 years in 2005-2006 NHANES (n 4419). Participants with high PDQ (33 %) had higher DASH index scores (mean 3.0 (sd 0.07)) than those with low PDQ (mean 2.5 (sd 0.06), P < 0.001), but average scores did not align with targets for intermediate or optimal DASH accordance. Adults with high PDQ reported higher total fat, saturated fat and Na intakes compared with optimal DASH nutrient goals. Differences between those with high v. low PDQ were similar for Whites and Blacks, but there was no difference between PDQ groups for Mexican Americans. Among Whites and Blacks, but not Mexican Americans, high PDQ may be associated with higher diet quality, but not necessarily a diet meeting DASH nutrient goals. This disconnect between PDQ and actual diet quality may serve as a target in obesity prevention.
JF - Public Health Nutrition
AU - Powell-Wiley, Tiffany M
AU - Miller, Paige E
AU - Agyemang, Priscilla
AU - Agurs-Collins, Tanya
AU - Reedy, Jill
AD - Cardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10 - Room 5E3340, Bethesda, MD 20892, USA, tiffany.powell@nih.gov
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 2641
EP - 2649
PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom
VL - 17
IS - 12
SN - 1368-9800, 1368-9800
KW - Risk Abstracts
KW - Diets
KW - Obesity
KW - Cholesterol
KW - Ingestion
KW - Nutrition
KW - Health risks
KW - USA
KW - Prevention
KW - Perception
KW - Proteins
KW - Ethnic groups
KW - Hypertension
KW - R2 23110:Psychological aspects
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627977482?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nutrition&rft.atitle=Perceived+and+objective+diet+quality+in+US+adults%3A+a+cross-sectional+analysis+of+the+National+Health+and+Nutrition+Examination+Survey+%28NHANES%29&rft.au=Powell-Wiley%2C+Tiffany+M%3BMiller%2C+Paige+E%3BAgyemang%2C+Priscilla%3BAgurs-Collins%2C+Tanya%3BReedy%2C+Jill&rft.aulast=Powell-Wiley&rft.aufirst=Tiffany&rft.date=2014-12-01&rft.volume=17&rft.issue=12&rft.spage=2641&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nutrition&rft.issn=13689800&rft_id=info:doi/10.1017%2FS1368980014000196
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-01
N1 - Number of references - 39
N1 - Last updated - 2014-12-24
N1 - SubjectsTermNotLitGenreText - Diets; Health risks; Obesity; Prevention; Perception; Proteins; Cholesterol; Ingestion; Nutrition; Ethnic groups; Hypertension; USA
DO - http://dx.doi.org/10.1017/S1368980014000196
ER -
TY - JOUR
T1 - Peritubular myoid cells participate in male mouse spermatogonial stem cell maintenance.
AN - 1627697485; 25181385
AB - Peritubular myoid (PM) cells surround the seminiferous tubule and together with Sertoli cells form the cellular boundary of the spermatogonial stem cell (SSC) niche. However, it remains unclear what role PM cells have in determining the microenvironment in the niche required for maintenance of the ability of SSCs to undergo self-renewal and differentiation into spermatogonia. Mice with a targeted disruption of the androgen receptor gene (Ar) in PM cells experienced a progressive loss of spermatogonia, suggesting that PM cells require testosterone (T) action to produce factors influencing SSC maintenance in the niche. Other studies showed that glial cell line-derived neurotrophic factor (GDNF) is required for SSC self-renewal and differentiation of SSCs in vitro and in vivo. This led us to hypothesize that T-regulated GDNF expression by PM cells contributes to the maintenance of SSCs. This hypothesis was tested using an adult mouse PM cell primary culture system and germ cell transplantation. We found that T induced GDNF expression at the mRNA and protein levels in PM cells. Furthermore, when thymus cell antigen 1-positive spermatogonia isolated from neonatal mice were cocultured with PM cells with or without T and transplanted to the testes of germ cell-depleted mice, the number and length of transplant-derived colonies was increased considerably by in vitro T treatment. These results support the novel hypothesis that T-dependent regulation of GDNF expression in PM cells has a significant influence on the microenvironment of the niche and SSC maintenance.
JF - Endocrinology
AU - Chen, Liang-Yu
AU - Brown, Paula R
AU - Willis, William B
AU - Eddy, Edward M
AD - Gamete Biology Group (L.-Y.C., W.B.W., E.M.E.) and Reproductive Developmental Biology Group (P.R.B.), Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 4964
EP - 4974
VL - 155
IS - 12
KW - Glial Cell Line-Derived Neurotrophic Factor
KW - 0
KW - Testosterone
KW - 3XMK78S47O
KW - Abridged Index Medicus
KW - Index Medicus
KW - Coculture Techniques
KW - Animals
KW - Mice, Inbred C57BL
KW - Spermatogonia -- physiology
KW - Male
KW - Adult Stem Cells -- transplantation
KW - Testis -- physiology
KW - Glial Cell Line-Derived Neurotrophic Factor -- metabolism
KW - Testosterone -- physiology
KW - Adult Stem Cells -- physiology
KW - Testis -- cytology
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627697485?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Peritubular+myoid+cells+participate+in+male+mouse+spermatogonial+stem+cell+maintenance.&rft.au=Chen%2C+Liang-Yu%3BBrown%2C+Paula+R%3BWillis%2C+William+B%3BEddy%2C+Edward+M&rft.aulast=Chen&rft.aufirst=Liang-Yu&rft.date=2014-12-01&rft.volume=155&rft.issue=12&rft.spage=4964&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2014-1406
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-08
N1 - Date created - 2014-11-22
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Cell Stem Cell. 2012 Oct 5;11(4):567-78 [23040482]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1210/en.2014-1406
ER -
TY - JOUR
T1 - A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a pediatric brain tumor consortium report.
AN - 1625347261; 24908656
AB - A phase I trial of veliparib (ABT-888), an oral poly(ADP-ribose) polymerase (PARP) inhibitor, and temozolomide (TMZ) was conducted in children with recurrent brain tumors to (i) estimate the maximum tolerated doses (MTDs) or recommended phase II doses (RP2Ds) of veliparib and TMZ; (ii) describe the toxicities of this regimen; and (iii) evaluate the plasma pharmacokinetic parameters and extent of PARP inhibition in peripheral blood mononuclear cells (PBMCs) following veliparib.
TMZ was given once daily and veliparib twice daily for 5 days every 28 days. Veliparib concentrations and poly(ADP-ribose) (PAR) levels in PBMCs were measured on days 1 and 4. Analysis of pharmacokinetic and PBMC PAR levels were performed twice during study conduct to rationally guide dose modifications and to determine biologically optimal MTD/RP2D. Twenty-nine evaluable patients were enrolled. Myelosuppression (grade 4 neutropenia and thrombocytopenia) were dose limiting. The RP2Ds are veliparib 25 mg/m(2) b.i.d. and TMZ 135 mg/m(2)/d. Only 2 out of 12 patients treated at RP2Ds experienced dose-limiting toxicities. Although no objective response was observed, 4 patients had stable disease >6 months in duration, including 1 with glioblastoma multiforme and 1 with ependymoma. At the RP2D of veliparib, pediatric pharmacokinetic parameters were similar to those in adults.
Veliparib and TMZ at the RP2D were well tolerated in children with recurrent brain tumors. A phase I/II trial to evaluate the tolerability and efficacy of veliparib, TMZ, and radiation in children with newly diagnosed brainstem gliomas is in progress. © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
JF - Neuro-oncology
AU - Su, Jack M
AU - Thompson, Patrick
AU - Adesina, Adekunle
AU - Li, Xiao-Nan
AU - Kilburn, Lindsay
AU - Onar-Thomas, Arzu
AU - Kocak, Mehmet
AU - Chyla, Brenda
AU - McKeegan, Evelyn
AU - Warren, Katherine E
AU - Goldman, Stewart
AU - Pollack, Ian F
AU - Fouladi, Maryam
AU - Chen, Alice
AU - Giranda, Vincent
AU - Boyett, James
AU - Kun, Larry
AU - Blaney, Susan M
AD - Texas Children's Cancer Center, Baylor College of Medicine (J.M.S., P.T., A.A., X-N.L., S.M.B.); Children's National Medical Center (L.K.); St. Jude Children's Research Hospital (A.O-T., J.B., L.K.); University of Tennessee Health Science Center (M.K.); AbbVie Pharmaceuticals (B.C., E.M., V.G.); National Cancer Institute, Pediatric Oncology Branch (K.E.W.); Children's Hospital of Chicago (S.G.); Children's Hospital of Pittsburgh (I.F.P.); Cincinnati Children's Hospital Medical Center (M.F.); Cancer Therapy Evaluation Program, National Cancer Institute (A.C.).
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 1661
EP - 1668
VL - 16
IS - 12
KW - Antineoplastic Agents, Alkylating
KW - 0
KW - Benzimidazoles
KW - Poly(ADP-ribose) Polymerase Inhibitors
KW - veliparib
KW - 01O4K0631N
KW - Dacarbazine
KW - 7GR28W0FJI
KW - Poly(ADP-ribose) Polymerases
KW - EC 2.4.2.30
KW - temozolomide
KW - YF1K15M17Y
KW - Index Medicus
KW - PARP inhibition
KW - ABT-888
KW - pediatric phase I study
KW - CNS tumors
KW - Infant
KW - Young Adult
KW - Poly(ADP-ribose) Polymerases -- blood
KW - Humans
KW - Leukocytes, Mononuclear -- metabolism
KW - Adult
KW - Child
KW - Maximum Tolerated Dose
KW - Adolescent
KW - Male
KW - Female
KW - Child, Preschool
KW - Dacarbazine -- therapeutic use
KW - Antineoplastic Agents, Alkylating -- therapeutic use
KW - Brain Neoplasms -- drug therapy
KW - Dacarbazine -- analogs & derivatives
KW - Benzimidazoles -- adverse effects
KW - Antineoplastic Agents, Alkylating -- adverse effects
KW - Benzimidazoles -- therapeutic use
KW - Antineoplastic Agents, Alkylating -- administration & dosage
KW - Benzimidazoles -- pharmacokinetics
KW - Dacarbazine -- adverse effects
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1625347261?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuro-oncology&rft.atitle=A+phase+I+trial+of+veliparib+%28ABT-888%29+and+temozolomide+in+children+with+recurrent+CNS+tumors%3A+a+pediatric+brain+tumor+consortium+report.&rft.au=Su%2C+Jack+M%3BThompson%2C+Patrick%3BAdesina%2C+Adekunle%3BLi%2C+Xiao-Nan%3BKilburn%2C+Lindsay%3BOnar-Thomas%2C+Arzu%3BKocak%2C+Mehmet%3BChyla%2C+Brenda%3BMcKeegan%2C+Evelyn%3BWarren%2C+Katherine+E%3BGoldman%2C+Stewart%3BPollack%2C+Ian+F%3BFouladi%2C+Maryam%3BChen%2C+Alice%3BGiranda%2C+Vincent%3BBoyett%2C+James%3BKun%2C+Larry%3BBlaney%2C+Susan+M&rft.aulast=Su&rft.aufirst=Jack&rft.date=2014-12-01&rft.volume=16&rft.issue=12&rft.spage=1661&rft.isbn=&rft.btitle=&rft.title=Neuro-oncology&rft.issn=1523-5866&rft_id=info:doi/10.1093%2Fneuonc%2Fnou103
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-06
N1 - Date created - 2014-11-15
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/neuonc/nou103
ER -
TY - JOUR
T1 - Abasic phosphorothioate oligomers inhibit HIV-1 reverse transcription and block virus transmission across polarized ectocervical organ cultures.
AN - 1625339001; 25224013
AB - In the absence of universally available antiretroviral (ARV) drugs or a vaccine against HIV-1, microbicides may offer the most immediate hope for controlling the AIDS pandemic. The most advanced and clinically effective microbicides are based on ARV agents that interfere with the earliest stages of HIV-1 replication. Our objective was to identify and characterize novel ARV-like inhibitors, as well as demonstrate their efficacy at blocking HIV-1 transmission. Abasic phosphorothioate 2' deoxyribose backbone (PDB) oligomers were evaluated in a variety of mechanistic assays and for their ability to inhibit HIV-1 infection and virus transmission through primary human cervical mucosa. Cellular and biochemical assays were used to elucidate the antiviral mechanisms of action of PDB oligomers against both lab-adapted and primary CCR5- and CXCR4-utilizing HIV-1 strains, including a multidrug-resistant isolate. A polarized cervical organ culture was used to test the ability of PDB compounds to block HIV-1 transmission to primary immune cell populations across ectocervical tissue. The antiviral activity and mechanisms of action of PDB-based compounds were dependent on oligomer size, with smaller molecules preventing reverse transcription and larger oligomers blocking viral entry. Importantly, irrespective of molecular size, PDBs potently inhibited virus infection and transmission within genital tissue samples. Furthermore, the PDB inhibitors exhibited excellent toxicity and stability profiles and were found to be safe for vaginal application in vivo. These results, coupled with the previously reported intrinsic anti-inflammatory properties of PDBs, support further investigations in the development of PDB-based topical microbicides for preventing the global spread of HIV-1.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
JF - Antimicrobial agents and chemotherapy
AU - Fraietta, Joseph A
AU - Mueller, Yvonne M
AU - Lozenski, Karissa L
AU - Ratner, Deena
AU - Boesteanu, Alina C
AU - Hancock, Aidan S
AU - Lackman-Smith, Carol
AU - Zentner, Isaac J
AU - Chaiken, Irwin M
AU - Chung, Suhman
AU - LeGrice, Stuart F J
AU - Snyder, Beth A
AU - Mankowski, Marie K
AU - Jones, Natalie M
AU - Hope, Jennifer L
AU - Gupta, Phalguni
AU - Anderson, Sharon H
AU - Wigdahl, Brian
AU - Katsikis, Peter D
AD - Department of Microbiology and Immunology and Center for Immunology and Vaccine Science, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA. ; Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. ; Southern Research Institute, Frederick, Maryland, USA. ; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA. ; HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA. ; Department of Obstetrics & Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA Main Line Fertility Center, Bryn Mawr, Pennsylvania, USA. ; Department of Microbiology and Immunology and Center for Immunology and Vaccine Science, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA peter.katsikis@drexelmed.edu.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 7056
EP - 7071
VL - 58
IS - 12
KW - CCR5 protein, human
KW - 0
KW - CXCR4 protein, human
KW - Phosphorothioate Oligonucleotides
KW - Receptors, CCR5
KW - Receptors, CXCR4
KW - Reverse Transcriptase Inhibitors
KW - Deoxyribose
KW - 533-67-5
KW - Index Medicus
KW - Vagina -- drug effects
KW - Epithelial Cells -- virology
KW - Animals
KW - Humans
KW - Gene Expression
KW - Receptors, CXCR4 -- antagonists & inhibitors
KW - Mice
KW - Sperm Motility -- drug effects
KW - Mucous Membrane -- drug effects
KW - Structure-Activity Relationship
KW - Epithelial Cells -- drug effects
KW - Mucous Membrane -- virology
KW - Receptors, CCR5 -- genetics
KW - Vagina -- virology
KW - Mice, Inbred C57BL
KW - Deoxyribose -- chemistry
KW - Organ Culture Techniques
KW - Receptors, CCR5 -- metabolism
KW - Female
KW - Male
KW - Phosphorothioate Oligonucleotides -- chemical synthesis
KW - Cervix Uteri -- drug effects
KW - HIV-1 -- genetics
KW - Reverse Transcriptase Inhibitors -- pharmacology
KW - HIV-1 -- growth & development
KW - Cervix Uteri -- virology
KW - HIV-1 -- enzymology
KW - Phosphorothioate Oligonucleotides -- pharmacology
KW - Reverse Transcriptase Inhibitors -- chemical synthesis
KW - HIV-1 -- drug effects
KW - Virus Internalization -- drug effects
KW - Reverse Transcription -- drug effects
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1625339001?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Abasic+phosphorothioate+oligomers+inhibit+HIV-1+reverse+transcription+and+block+virus+transmission+across+polarized+ectocervical+organ+cultures.&rft.au=Fraietta%2C+Joseph+A%3BMueller%2C+Yvonne+M%3BLozenski%2C+Karissa+L%3BRatner%2C+Deena%3BBoesteanu%2C+Alina+C%3BHancock%2C+Aidan+S%3BLackman-Smith%2C+Carol%3BZentner%2C+Isaac+J%3BChaiken%2C+Irwin+M%3BChung%2C+Suhman%3BLeGrice%2C+Stuart+F+J%3BSnyder%2C+Beth+A%3BMankowski%2C+Marie+K%3BJones%2C+Natalie+M%3BHope%2C+Jennifer+L%3BGupta%2C+Phalguni%3BAnderson%2C+Sharon+H%3BWigdahl%2C+Brian%3BKatsikis%2C+Peter+D&rft.aulast=Fraietta&rft.aufirst=Joseph&rft.date=2014-12-01&rft.volume=58&rft.issue=12&rft.spage=7056&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=1098-6596&rft_id=info:doi/10.1128%2FAAC.02991-14
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-07
N1 - Date created - 2014-11-13
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1128/AAC.02991-14
ER -
TY - JOUR
T1 - What happens when people discontinue taking medications? Lessons from COMBINE
AN - 1625335697; 4619060
AB - We use intensive longitudinal data methods to illuminate processes affecting patients' drinking in relation to the discontinuation of medications within an alcohol treatment study. Although previous work has focused on broad measures of medication adherence, we focus on dynamic changes in drinking both before and after patients discontinue. We conducted secondary data analyses using the COMBINE (Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence) study, focused on participants who discontinued medications prior to the planned end of treatment. Using an interrupted time-series analysis, we analysed drinking in the weeks before and after discontinuation and also studied outcomes at the end of the COMBINE follow-up. We describe the subsample of COMBINE participants who discontinued medications (n=450), and compare them with those who were medication-adherent (n=559) and with those who discontinued but had substantial missing data (n=217). The primary outcomes were percentage of days abstinent (PDA) and percentage of heavy drinking days (PHDD). Medication adherence data were used to approximate the date of discontinuation. For many patients, an increase in drinking began weeks before discontinuation (PDA: F(1,4803) =19.07, P<0.001; PHDD: F(1,4804)=8.58, P=0.003) then escalated at discontinuation (PDA: F(1,446)=5.05, P=0.025; PHDD: F(1,446)=4.52, P=0.034). Among other effects, the amount of change was moderated by the reason for discontinuation (e.g. adverse event; PDA: F(2,4803)=3.85, P=0.021; PHDD: F(2,4804)=5.36, P=0.005) and also whether it occurred in the first or second half of treatment (PDA: F(1,4803)=5.23, P=0.022; PHDD: F(1,4804)=8.79, P=0.003). A patient's decision to stop taking medications during alcohol treatment appears to take place during a weeks-long process of disengagement from treatment. Patients who discontinue medications early in treatment or without medical consultation appear to drink more frequently and more heavily. Reprinted by permission of Blackwell Publishing
JF - Addiction
AU - Falk, Daniel
AU - Stout, Robert L
AU - Braciszewski, Jordan M
AU - Subbaraman, Meenakshi Sabina
AU - Kranzler, Henry R
AU - O'malley, Stephanie S
AD - Pacific Institute for Research and Evaluation ; University of California, Berkeley ; University of Pennsylvania ; Yale University ; National Institute on Alcohol Abuse and Alcoholism
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 2044
EP - 2052
VL - 109
IS - 12
SN - 0965-2140, 0965-2140
KW - Sociology
KW - Alcohol
KW - Medical care
KW - Pharmaceuticals
KW - Medicine
KW - Patients
KW - Medical treatment
KW - Addiction
KW - Drugs
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1625335697?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=What+happens+when+people+discontinue+taking+medications%3F+Lessons+from+COMBINE&rft.au=Falk%2C+Daniel%3BStout%2C+Robert+L%3BBraciszewski%2C+Jordan+M%3BSubbaraman%2C+Meenakshi+Sabina%3BKranzler%2C+Henry+R%3BO%27malley%2C+Stephanie+S&rft.aulast=Falk&rft.aufirst=Daniel&rft.date=2014-12-01&rft.volume=109&rft.issue=12&rft.spage=2044&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.12700
LA - English
DB - International Bibliography of the Social Sciences (IBSS)
N1 - Date revised - 2014-11-17
N1 - Last updated - 2014-11-17
N1 - SubjectsTermNotLitGenreText - 7875 5775 13521; 7890 5792 10484; 3755; 9474; 9271 7890 5792 10484; 909; 561 6220; 7894
DO - http://dx.doi.org/10.1111/add.12700
ER -
TY - JOUR
T1 - Unrelated solubility-enhancing fusion partners MBP and NusA utilize a similar mode of action
AN - 1622606905; 20891073
AB - The tendency of recombinant proteins to accumulate in the form of insoluble aggregates in Escherichia coli is a major hindrance to their overproduction. One of the more effective approaches to circumvent this problem is to use translation fusion partners {solubility-enhancers (SEs)}. E. coli maltose-binding protein (MBP) and N-utilization substance A (NusA) are arguably the most effective solubilizing agents that have been discovered so far. Here, we show that although these two proteins are structurally, functionally, and physicochemically distinct, they influence the solubility and folding of their fusion partners in a very similar manner. These SEs act as "holdases" that prevent the aggregation of their fusion partners. Subsequent folding of the passenger proteins, when it occurs, is either spontaneous or chaperone-mediated. Biotechnol. Bioeng. 2014; 111: 2407-2411. copyright 2014 Wiley Periodicals, Inc. The structures of MBP (PDB:10MP) and NusA (PDB:1L2F) are radically different, as illustrated by these ribbon models, but they utilize a similar mechanism of action to enhance the solubility of their fusion partners. Amino- and carboxy-termini are labeled N and C, respectively. Passenger proteins are fused to the C-termini. Alpha helices and beta sheets are colored cyan and pink, respectively.
JF - Biotechnology and Bioengineering
AU - Raran-Kurussi, Sreejith
AU - Waugh, David S
AD - Protein Engineering Section, Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland.
Y1 - 2014/12//
PY - 2014
DA - Dec 2014
SP - 2407
EP - 2411
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 111
IS - 12
SN - 0006-3592, 0006-3592
KW - Biotechnology and Bioengineering Abstracts
KW - Protein structure
KW - Translation
KW - Solubility
KW - Escherichia coli
KW - maltose-binding protein
KW - Models
KW - W 30925:Genetic Engineering
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-01
N1 - Last updated - 2015-10-28
N1 - SubjectsTermNotLitGenreText - Protein structure; Translation; Solubility; maltose-binding protein; Models; Escherichia coli
DO - http://dx.doi.org/10.1002/bit.25317
ER -
TY - JOUR
T1 - Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk.
AN - 1622065517; 25179167
AB - Chronic cigarette smoking exposes airway epithelial cells to thousands of carcinogens, oxidants and DNA-damaging agents, creating a field of molecular injury in the airway and altering gene expression. Studies of cytologically normal bronchial epithelial cells from smokers have identified transcription-based biomarkers that may prove useful in early diagnosis of lung cancer, including a number of p53-regulated genes. The ability of p53 to regulate transcription is critical for tumor suppression, and this suggests that single-nucleotide polymorphisms (SNPs) in functional p53 binding sites (p53 response elements, or p53REs) that affect gene expression could influence susceptibility to cancer. To connect p53RE SNP genotype with gene expression and cancer risk, we identified a set of 204 SNPs in putative p53REs, and performed cis expression quantitative trait loci (eQTL) analysis, assessing associations between SNP genotypes and mRNA levels of adjacent genes in bronchial epithelial cells obtained from 44 cigarette smokers. To further test and validate these genotype-expression associations, we searched published eQTL studies from independent populations and determined that 53% (39/74) of the bronchial epithelial eQTLs were observed in at least one of other studies. SNPs in p53REs were also evaluated for effects on p53-DNA binding using a quantitative in vitro protein-DNA binding assay. Last, based on linkage disequilibrium, we found 6 p53RE SNPs associated with gene expression were identified as cancer risk SNPs by either genome-wide association studies or candidate gene studies. We provide an approach for identifying and evaluating potentially functional SNPs that may modulate the airway gene expression response to smoking and may influence susceptibility to cancers.
JF - Human genetics
AU - Wang, Xuting
AU - Pittman, Gary S
AU - Bandele, Omari J
AU - Bischof, Jason J
AU - Liu, Gang
AU - Brothers, John F
AU - Spira, Avrum
AU - Bell, Douglas A
AD - Environmental Genomics Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Mail Drop: C3-03, 111 TW Alexander Drive, PO Box 12233, Research Triangle Park, NC, 27709, USA.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 1467
EP - 1476
VL - 133
IS - 12
KW - TP53 protein, human
KW - 0
KW - Tumor Suppressor Protein p53
KW - Index Medicus
KW - Polymorphism, Single Nucleotide
KW - Oligonucleotide Array Sequence Analysis
KW - Humans
KW - Quantitative Trait Loci
KW - Genetic Association Studies
KW - Linkage Disequilibrium
KW - Protein Binding
KW - Respiratory Mucosa -- pathology
KW - Binding Sites
KW - Risk
KW - Base Sequence
KW - Respiratory Mucosa -- metabolism
KW - Genetic Predisposition to Disease
KW - Transcriptome
KW - Epithelial Cells -- metabolism
KW - Tumor Suppressor Protein p53 -- physiology
KW - Lung Neoplasms -- etiology
KW - Smoking -- metabolism
KW - Smoking -- adverse effects
KW - Response Elements
KW - Lung Neoplasms -- metabolism
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-12
N1 - Date created - 2014-11-08
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1007/s00439-014-1483-8
ER -
TY - JOUR
T1 - Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways.
AN - 1619319008; 25217484
AB - Schisandra sphenanthera is widely used as a tonic and restorative in many countries to enhance the function of liver and other organs. Wuzhi tablet (WZ) is a preparation of an ethanol extract of Schisandra sphenanthera. Our previous study demonstrated that WZ exerted a protective effect toward acetaminophen (APAP)-induced hepatotoxicity. However, the molecular mechanisms of this protection remain unclear. This study aimed to determine what molecular pathways contributed to the hepatoprotective effects of WZ against APAP toxicity. Administration of WZ 3 days before APAP treatment significantly attenuated APAP hepatotoxicity in a dose-dependent manner and reduced APAP-induced JNK activation. Treatment with WZ resulted in potent inhibition of CYP2E1, CYP3A11, and CYP1A2 activities and then caused significant inhibition of the formation of the oxidized APAP metabolite N-acetyl-p-benzoquinone imine-reduced glutathione. The expression of NRF2 was increased after APAP and/or WZ treatment, whereas KEAP1 levels were decreased. The protein expression of NRF2 target genes including Gclc, Gclm, Ho-1, and Nqo1 was significantly increased by WZ treatment. Furthermore, APAP increased the levels of p53 and its downstream gene p21 to trigger cell cycle arrest and apoptosis, whereas WZ pretreatment could inhibit p53/p21 signaling to induce cell proliferation-associated proteins including cyclin D1, CDK4, PCNA, and ALR to promote hepatocyte proliferation. This study demonstrated that WZ prevented APAP-induced liver injury by inhibition of cytochrome P450-mediated APAP bioactivation, activation of the NRF2-antioxidant response element pathway to induce detoxification and antioxidation, and regulation of the p53, p21, cyclin D1, CDK4, PCNA, and ALR to facilitate liver regeneration after APAP-induced liver injury.
U.S. Government work not protected by U.S. copyright.
JF - Drug metabolism and disposition: the biological fate of chemicals
AU - Fan, Xiaomei
AU - Jiang, Yiming
AU - Wang, Ying
AU - Tan, Huasen
AU - Zeng, Hang
AU - Wang, Yongtao
AU - Chen, Pan
AU - Qu, Aijuan
AU - Gonzalez, Frank J
AU - Huang, Min
AU - Bi, Huichang
AD - School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (X.F., Y.J., Yo.W., H.T., H.Z., Yi. W., M.H., H.B.); The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China (P.C.); and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (A.Q., F.J.G). ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (X.F., Y.J., Yo.W., H.T., H.Z., Yi. W., M.H., H.B.); The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China (P.C.); and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (A.Q., F.J.G) bihchang@mail.sysu.edu.cn.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 1982
EP - 1990
VL - 42
IS - 12
KW - Antioxidants
KW - 0
KW - Cyclin-Dependent Kinase Inhibitor p21
KW - Drugs, Chinese Herbal
KW - NF-E2-Related Factor 2
KW - Nfe2l2 protein, mouse
KW - Plant Extracts
KW - Protective Agents
KW - Tablets
KW - Tumor Suppressor Protein p53
KW - wuzhi
KW - Acetaminophen
KW - 362O9ITL9D
KW - Cytochrome P-450 Enzyme System
KW - 9035-51-2
KW - Carboxylic Ester Hydrolases
KW - EC 3.1.1.-
KW - arylesterase
KW - EC 3.1.1.2
KW - Index Medicus
KW - Cell Proliferation -- drug effects
KW - Animals
KW - Hepatocytes -- drug effects
KW - Acetaminophen -- adverse effects
KW - Liver -- metabolism
KW - Mice
KW - Protective Agents -- pharmacology
KW - Tablets -- pharmacology
KW - Plant Extracts -- pharmacology
KW - Antioxidants -- pharmacology
KW - Liver -- drug effects
KW - Signal Transduction -- drug effects
KW - Mice, Inbred C57BL
KW - Male
KW - Hepatocytes -- metabolism
KW - Carboxylic Ester Hydrolases -- metabolism
KW - Schisandra -- chemistry
KW - Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
KW - Tumor Suppressor Protein p53 -- metabolism
KW - Drugs, Chinese Herbal -- pharmacology
KW - Chemical and Drug Induced Liver Injury -- metabolism
KW - Chemical and Drug Induced Liver Injury -- drug therapy
KW - NF-E2-Related Factor 2 -- metabolism
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Wuzhi+tablet+%28Schisandra+Sphenanthera+extract%29+protects+against+acetaminophen-induced+hepatotoxicity+by+inhibition+of+CYP-mediated+bioactivation+and+regulation+of+NRF2-ARE+and+p53%2Fp21+pathways.&rft.au=Fan%2C+Xiaomei%3BJiang%2C+Yiming%3BWang%2C+Ying%3BTan%2C+Huasen%3BZeng%2C+Hang%3BWang%2C+Yongtao%3BChen%2C+Pan%3BQu%2C+Aijuan%3BGonzalez%2C+Frank+J%3BHuang%2C+Min%3BBi%2C+Huichang&rft.aulast=Fan&rft.aufirst=Xiaomei&rft.date=2014-12-01&rft.volume=42&rft.issue=12&rft.spage=1982&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.114.059535
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-01
N1 - Date created - 2014-11-01
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1124/dmd.114.059535
ER -
TY - JOUR
T1 - Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases.
AN - 1614700436; 25043383
AB - Activation of microglial NADPH oxidase (NOX2) plays a critical role in mediating neuroinflammation, which is closely linked with the pathogenesis of a variety of neurodegenerative diseases, including Parkinson's disease (PD). The inhibition of NOX2-generated superoxide has become an effective strategy for developing disease-modifying therapies for PD. However, the lack of specific and potent NOX2 inhibitors has hampered the progress of this approach. Diphenyleneiodonium (DPI) is a widely used, long-acting NOX2 inhibitor. However, due to its non-specificity for NOX2 and high cytotoxicity at standard doses (µM), DPI has been precluded from human studies. In this study, using ultra-low doses of DPI, we aimed to: (1) investigate whether these problems could be circumvented and (2) determine whether ultra-low doses of DPI were able to preserve its utility as a potent NOX2 inhibitor. We found that DPI at subpicomolar concentrations (10(-14) and 10(-13) M) displays no toxicity in primary midbrain neuron-glia cultures. More importantly, we observed that subpicomolar DPI inhibited phorbol myristate acetate (PMA)-induced activation of NOX2. The same concentrations of DPI did not inhibit the activities of a series of flavoprotein-containing enzymes. Furthermore, potent neuroprotective efficacy was demonstrated in a post-treatment study. When subpicomolar DPI was added to neuron-glia cultures pretreated with lipopolysaccharide, 1-methyl-4-phenylpyridinium or rotenone, it potently protected the dopaminergic neurons. In summary, DPI's unique combination of high specificity toward NOX2, low cytotoxicity and potent neuroprotective efficacy in post-treatment regimens suggests that subpicomolar DPI may be an ideal candidate for further animal studies and potential clinical trials.
© 2014 Wiley Periodicals, Inc.
JF - Glia
AU - Wang, Qingshan
AU - Chu, Chun-Hsien
AU - Oyarzabal, Esteban
AU - Jiang, Lulu
AU - Chen, Shih-Heng
AU - Wilson, Belinda
AU - Qian, Li
AU - Hong, Jau-Shyong
AD - Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 2034
EP - 2043
VL - 62
IS - 12
KW - Aif1 protein, rat
KW - 0
KW - Calcium-Binding Proteins
KW - Enzyme Inhibitors
KW - Glial Fibrillary Acidic Protein
KW - Microfilament Proteins
KW - Nitrites
KW - Onium Compounds
KW - Superoxides
KW - 11062-77-4
KW - diphenyleneiodonium
KW - 6HJ411TU98
KW - Nitric Oxide Synthase Type II
KW - EC 1.14.13.39
KW - Tyrosine 3-Monooxygenase
KW - EC 1.14.16.2
KW - Xanthine Oxidase
KW - EC 1.17.3.2
KW - NADPH-Ferrihemoprotein Reductase
KW - EC 1.6.2.4
KW - NADPH Oxidase
KW - EC 1.6.3.1
KW - Electron Transport Complex I
KW - EC 1.6.5.3
KW - Thioredoxin-Disulfide Reductase
KW - EC 1.8.1.9
KW - Dopamine
KW - VTD58H1Z2X
KW - Index Medicus
KW - microglia
KW - Parkinson's disease
KW - oxidative stress
KW - neuroinflammation
KW - NADPH oxidase
KW - Xanthine Oxidase -- metabolism
KW - Animals
KW - Tyrosine 3-Monooxygenase -- metabolism
KW - Microfilament Proteins -- metabolism
KW - Cell Count
KW - Nitrites -- metabolism
KW - Neurons -- drug effects
KW - Electron Transport Complex I -- metabolism
KW - Glial Fibrillary Acidic Protein -- metabolism
KW - Dopamine -- metabolism
KW - NADPH-Ferrihemoprotein Reductase -- metabolism
KW - Mesencephalon -- cytology
KW - Superoxides -- metabolism
KW - Cells, Cultured
KW - Thioredoxin-Disulfide Reductase -- metabolism
KW - Neurons -- physiology
KW - Nitric Oxide Synthase Type II -- metabolism
KW - Calcium-Binding Proteins -- metabolism
KW - NADPH Oxidase -- metabolism
KW - Onium Compounds -- pharmacology
KW - Enzyme Inhibitors -- pharmacology
KW - Microglia -- drug effects
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-06-19
N1 - Date created - 2014-10-20
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
FASEB J. 2005 Apr;19(6):550-7 [15791005]
Antioxid Redox Signal. 2014 Jun 10;20(17):2741-54 [24070014]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1002/glia.22724
ER -
TY - JOUR
T1 - PET and NIR optical imaging using self-illuminating (64)Cu-doped chelator-free gold nanoclusters.
AN - 1566409017; 25224367
AB - Self-illuminating fluorescence imaging without autofluorescence background interference has recently aroused more research interests in molecular imaging. Currently, only a few self-illuminating probes were developed, based mainly on toxic quantum dots such as CdSe, CdTe. Herein, we report a novel design of nontoxic self-illuminating gold nanocluster ((64)Cu-doped AuNCs) for dual-modality positron emission tomography (PET) and near-infrared (NIR) fluorescence imaging based on Cerenkov resonance energy transfer (CRET). PET radionuclide (64)Cu was introduced by a chelator-free doping method, which played dual roles as the energy donor and the PET imaging source. Meanwhile, AuNCs acted as the energy acceptor for NIR fluorescence imaging. (64)Cu-doped AuNCs exhibited efficient CRET-NIR and PET imaging both in vitro and in vivo. In a U87MG glioblastoma xenograft model, (64)Cu-doped AuNCs showed high tumor uptake (14.9 %ID/g at 18 h) and produced satisfactory tumor self-illuminating NIR images in the absence of external excitation. This self-illuminating nanocluster with non-toxicity and good biocompatibility can be employed as a novel imaging contrast agent for biomedical applications, especially for molecular imaging.
Published by Elsevier Ltd.
JF - Biomaterials
AU - Hu, Hao
AU - Huang, Peng
AU - Weiss, Orit Jacobson
AU - Yan, Xuefeng
AU - Yue, Xuyi
AU - Zhang, Molly Gu
AU - Tang, Yuxia
AU - Nie, Liming
AU - Ma, Ying
AU - Niu, Gang
AU - Wu, Kaichun
AU - Chen, Xiaoyuan
AD - State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, USA. ; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, USA. ; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, USA; Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China. ; State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China. Electronic address: kaicwu@fmmu.edu.cn. ; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, USA. Electronic address: shawn.chen@nih.gov.
Y1 - 2014/12//
PY - 2014
DA - December 2014
SP - 9868
EP - 9876
VL - 35
IS - 37
KW - Isotopes
KW - 0
KW - Gold
KW - 7440-57-5
KW - Copper
KW - 789U1901C5
KW - Index Medicus
KW - Gold nanocluster
KW - Positron emission tomography
KW - Optical imaging
KW - (64)Cu doping
KW - Cerenkov effect
KW - Animals
KW - Infrared Rays
KW - Humans
KW - Mice
KW - Cell Line, Tumor
KW - Optical Imaging -- methods
KW - Nanostructures -- chemistry
KW - Positron-Emission Tomography -- methods
KW - Glioblastoma -- diagnosis
KW - Gold -- chemistry
KW - Copper -- chemistry
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566409017?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=PET+and+NIR+optical+imaging+using+self-illuminating+%2864%29Cu-doped+chelator-free+gold+nanoclusters.&rft.au=Hu%2C+Hao%3BHuang%2C+Peng%3BWeiss%2C+Orit+Jacobson%3BYan%2C+Xuefeng%3BYue%2C+Xuyi%3BZhang%2C+Molly+Gu%3BTang%2C+Yuxia%3BNie%2C+Liming%3BMa%2C+Ying%3BNiu%2C+Gang%3BWu%2C+Kaichun%3BChen%2C+Xiaoyuan&rft.aulast=Hu&rft.aufirst=Hao&rft.date=2014-12-01&rft.volume=35&rft.issue=37&rft.spage=9868&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=1878-5905&rft_id=info:doi/10.1016%2Fj.biomaterials.2014.08.038
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-06-03
N1 - Date created - 2014-09-29
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.biomaterials.2014.08.038
ER -
TY - JOUR
T1 - Changes in human pluripotent stem cell gene expression after genotoxic stress exposures.
AN - 1637571708; 25426256
AB - Human pluripotent stem cells (hPSCs) represent heterogeneous populations, including induced pluripotent stem cells (iPSCs), endogenous plastic somatic cells, and embryonic stem cells (ESCs). Human ESCs are derived from the inner cell mass of the blastocyst, and they are characterized by the abilities to self-renew indefinitely, and to give rise to all cell types of embryonic lineage (pluripotency) under the guidance of the appropriate chemical, mechanical and environmental cues. The combination of these critical features is unique to hESCs, and set them apart from other human cells. The expectations are high to utilize hESCs for treating injuries and degenerative diseases; for modeling of complex illnesses and development; for screening and testing of pharmacological products; and for examining toxicity, mutagenicity, teratogenicity, and potential carcinogenic effects of a variety of environmental factors, including ionizing radiation (IR). Exposures to genotoxic stresses, such as background IR, are unavoidable; moreover, IR is widely used in diagnostic and therapeutic procedures in medicine on a routine basis. One of the key outcomes of cell exposures to IR is the change in gene expression, which may underlie the ultimate hESCs fate after such a stress. However, gaps in our knowledge about basic biology of hESCs impose a serious limitation to fully realize the potential of hESCs in practice. The purpose of this review is to examine the available evidence of alterations in gene expression in human pluripotent stem cells after genotoxic stress, and to discuss strategies for future research in this important area.
JF - World journal of stem cells
AU - Sokolov, Mykyta V
AU - Neumann, Ronald D
AD - Mykyta V Sokolov, Ronald D Neumann, Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20892, United States.
Y1 - 2014/11/26/
PY - 2014
DA - 2014 Nov 26
SP - 598
EP - 605
VL - 6
IS - 5
KW - Ionizing radiation
KW - Gene expression alterations
KW - Human pluripotent stem cells
KW - Genotoxic stress
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1637571708?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+journal+of+stem+cells&rft.atitle=Changes+in+human+pluripotent+stem+cell+gene+expression+after+genotoxic+stress+exposures.&rft.au=Sokolov%2C+Mykyta+V%3BNeumann%2C+Ronald+D&rft.aulast=Sokolov&rft.aufirst=Mykyta&rft.date=2014-11-26&rft.volume=6&rft.issue=5&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=World+journal+of+stem+cells&rft.issn=&rft_id=info:doi/10.4252%2Fwjsc.v6.i5.598
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-11-26
N1 - Date created - 2014-11-26
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.4252/wjsc.v6.i5.598
ER -
TY - JOUR
T1 - Association of serum alpha -tocopherol, beta -carotene, and retinol with liver cancer incidence and chronic liver disease mortality
AN - 1635028256; 21050931
AB - Background: Micronutrients may influence the development or progression of liver cancer and liver disease. We evaluated the association of serum alpha -tocopherol, beta -carotene, and retinol with incident liver cancer and chronic liver disease (CLD) mortality in a prospective cohort of middle-aged Finnish male smokers. Methods: Baseline and 3-year follow-up serum were available from 29 046 and 22 805 men, respectively. After 24 years of follow-up, 208 men were diagnosed with liver cancer and 237 died from CLD. Hazards ratios and 95% confidence intervals were calculated for highest vs lowest quartiles from multivariate proportional hazards models. Results: Higher beta -carotene and retinol levels were associated with less liver cancer ( beta -carotene: 0.35, 0.22-0.55, P-trend <0.0001; retinol: 0.58, 0.39-0.85, P-trend=0.0009) and CLD mortality ( beta -carotene: 0.47, 0.30-0.75, P-trend=0.001; retinol: 0.55, 0.38-0.78, P-trend=0.0007). alpha -Tocopherol was associated with CLD mortality (0.63, 0.40-0.99, P-trend=0.06), but not with liver cancer (1.06, 0.64-1.74, P-trend=0.77). Participants with higher levels of beta -carotene and retinol, but not alpha -tocopherol, at both baseline and year 3 had lower risk of each outcome than those with lower levels. Conclusions: Our findings suggest that higher concentrations of beta -carotene and retinol are associated with incident liver cancer and CLD. However, such data do not indicate that supplementation should be considered for these diseases.
JF - British Journal of Cancer
AU - Lai, G Y
AU - Weinstein, S J
AU - Albanes, D
AU - Taylor, P R
AU - Virtamo, J
AU - McGlynn, K A
AU - Freedman, N D
AD - 1] Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD 20892, USA [2] Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Room 6E316, Bethesda, MD 20892, USA
Y1 - 2014/11/25/
PY - 2014
DA - 2014 Nov 25
SP - 2163
EP - 2171
PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom
VL - 111
IS - 11
SN - 0007-0920, 0007-0920
KW - Risk Abstracts
KW - Health risks
KW - Mortality
KW - Liver
KW - Micronutrients
KW - Cancer
KW - R2 23060:Medical and environmental health
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Association+of+serum+alpha+-tocopherol%2C+beta+-carotene%2C+and+retinol+with+liver+cancer+incidence+and+chronic+liver+disease+mortality&rft.au=Lai%2C+G+Y%3BWeinstein%2C+S+J%3BAlbanes%2C+D%3BTaylor%2C+P+R%3BVirtamo%2C+J%3BMcGlynn%2C+K+A%3BFreedman%2C+N+D&rft.aulast=Lai&rft.aufirst=G&rft.date=2014-11-25&rft.volume=111&rft.issue=11&rft.spage=2163&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2014.365
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Last updated - 2015-02-12
N1 - SubjectsTermNotLitGenreText - Mortality; Health risks; Liver; Micronutrients; Cancer
DO - http://dx.doi.org/10.1038/bjc.2014.365
ER -
TY - JOUR
T1 - Dialogue between skin microbiota and immunity
AN - 1811903667; PQ0003455265
AB - Human skin, the body's largest organ, functions as a physical barrier to bar the entry of foreign pathogens, while concomitantly providing a home to myriad commensals. Over a human's life span, keratinized skin cells, immune cells, and microbes all interact to integrate the processes of maintaining skin's physical and immune barrier under homeostatic healthy conditions and also under multiple stresses, such as wounding or infection. In this Review, we explore the intricate interactions of microbes and immune cells on the skin surface and within associated appendages to regulate this orchestrated maturation in the context of both host physiological changes and environmental challenges.
JF - Science
AU - Belkaid, Yasmine
AU - Segre, Julia A
AD - Program in Barrier Immunity and Repair and Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institute of Health (NIH), Bethesda, MD, USA, ybelkaid@niaid.nih.gov
Y1 - 2014/11/21/
PY - 2014
DA - 2014 Nov 21
SP - 954
EP - 959
PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 United States
VL - 346
IS - 6212
SN - 0036-8075, 0036-8075
KW - Microbiology Abstracts A: Industrial & Applied Microbiology
KW - Skin
KW - Commensals
KW - Stress
KW - Pathogens
KW - Immunity
KW - Infection
KW - Wounding
KW - A 01450:Environmental Pollution & Waste Treatment
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811903667?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=Dialogue+between+skin+microbiota+and+immunity&rft.au=Belkaid%2C+Yasmine%3BSegre%2C+Julia+A&rft.aulast=Belkaid&rft.aufirst=Yasmine&rft.date=2014-11-21&rft.volume=346&rft.issue=6212&rft.spage=954&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1260144
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-08-01
N1 - Last updated - 2016-08-17
N1 - SubjectsTermNotLitGenreText - Skin; Commensals; Stress; Immunity; Pathogens; Infection; Wounding
DO - http://dx.doi.org/10.1126/science.1260144
ER -
TY - CPAPER
T1 - Immuno-spin trapping of alpha-synuclein radical formed in Maneb and paraquat-induced models of Parkinson's disease
T2 - 21st Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2014)
AN - 1645171810; 6325161
JF - 21st Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2014)
AU - Kumar, Ashutosh
Y1 - 2014/11/19/
PY - 2014
DA - 2014 Nov 19
KW - Synuclein
KW - Neurodegenerative diseases
KW - Movement disorders
KW - Parkinson's disease
KW - Trapping
KW - Models
KW - Radicals
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645171810?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2014%29&rft.atitle=Immuno-spin+trapping+of+alpha-synuclein+radical+formed+in+Maneb+and+paraquat-induced+models+of+Parkinson%27s+disease&rft.au=Kumar%2C+Ashutosh&rft.aulast=Kumar&rft.aufirst=Ashutosh&rft.date=2014-11-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2014%29&rft.issn=&rft_id=info:doi/
L2 - http://www.sfrbm.org/pdf/SFRBM2014-OralPresentations.pdf
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - Nrf2 in Human (and Mouse) Diseases
T2 - 21st Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2014)
AN - 1645169186; 6325136
JF - 21st Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2014)
AU - Kleeberger, Steven
Y1 - 2014/11/19/
PY - 2014
DA - 2014 Nov 19
KW - Public health
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645169186?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2014%29&rft.atitle=Nrf2+in+Human+%28and+Mouse%29+Diseases&rft.au=Kleeberger%2C+Steven&rft.aulast=Kleeberger&rft.aufirst=Steven&rft.date=2014-11-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2014%29&rft.issn=&rft_id=info:doi/
L2 - http://www.sfrbm.org/sections/annual-meeting/21st-annual-meeting-program
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - Peripherally restricted, selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity by attenuating oxidative/nitrative stress and inflammation
T2 - 21st Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2014)
AN - 1645168979; 6325165
JF - 21st Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2014)
AU - Pacher, Pal
Y1 - 2014/11/19/
PY - 2014
DA - 2014 Nov 19
KW - Cannabinoid CB2 receptors
KW - Stress
KW - Inflammation
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L2 - http://www.sfrbm.org/pdf/SFRBM2014-OralPresentations.pdf
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - Goals and Priorities of the National Institute of Environmental Health Sciences (NIEHS)
T2 - 21st Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2014)
AN - 1645168841; 6325148
JF - 21st Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2014)
AU - Reinlib, Leslie
Y1 - 2014/11/19/
PY - 2014
DA - 2014 Nov 19
KW - Priorities
KW - Environmental health
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645168841?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2014%29&rft.atitle=Goals+and+Priorities+of+the+National+Institute+of+Environmental+Health+Sciences+%28NIEHS%29&rft.au=Reinlib%2C+Leslie&rft.aulast=Reinlib&rft.aufirst=Leslie&rft.date=2014-11-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2014%29&rft.issn=&rft_id=info:doi/
L2 - http://www.sfrbm.org/sections/annual-meeting/21st-annual-meeting-program
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - Malaria vector diversity in Southeast Asia and beyond: Challenges and opportunities
T2 - 62nd Annual Meeting of the Entomological Society of America (Entomology 2014)
AN - 1645158326; 6323004
JF - 62nd Annual Meeting of the Entomological Society of America (Entomology 2014)
AU - St Laurent, Brandyce
Y1 - 2014/11/16/
PY - 2014
DA - 2014 Nov 16
KW - Species diversity
KW - Vectors
KW - Malaria
KW - Southeast Asia
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645158326?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=62nd+Annual+Meeting+of+the+Entomological+Society+of+America+%28Entomology+2014%29&rft.atitle=Malaria+vector+diversity+in+Southeast+Asia+and+beyond%3A+Challenges+and+opportunities&rft.au=St+Laurent%2C+Brandyce&rft.aulast=St+Laurent&rft.aufirst=Brandyce&rft.date=2014-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=62nd+Annual+Meeting+of+the+Entomological+Society+of+America+%28Entomology+2014%29&rft.issn=&rft_id=info:doi/
L2 - https://esa.confex.com/esa/2014/webprogram/meeting.html
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - JOUR
T1 - Diminished Systemic and Antigen-Specific Type 1, Type 17, and Other Proinflammatory Cytokines in Diabetic and Prediabetic Individuals With Latent Mycobacterium tuberculosis Infection
AN - 1694971749; PQ0001607954
AB - Background. Diabetes mellitus type 2 (DM) is known to be a major risk factor for the development of active tuberculosis, although its influence on latent Mycobacterium tuberculosis infection (hereafter, "latent infection") remains poorly characterized. Methods. We examined circulating plasma cytokine levels in individuals with latent infection with DM or pre-DM (ie, intermediate hyperglycemia) and compared them to levels in patients with latent infection and normal glycemic control. Results. In persons with DM or pre-DM, latent infection is characterized by diminished circulating levels of type 1 (interferon gamma , interleukin 2, and tumor necrosis factor alpha ) and type 17 (interleukin 17F) cytokines. This was associated with decreased systemic levels of other proinflammatory cytokines (interleukin 1 beta and interleukin 18) and the antiinflammatory cytokine interleukin 10 but not with decreased systemic levels of type 2 cytokines. Moreover, latently infected individuals with DM had diminished levels of spontaneous and M. tuberculosis antigen-specific levels of type 1 and type 17 cytokines when antigen-stimulated whole blood was examined. Finally, there was no significant correlation between the levels of any of the cytokines measured (with the exception of interleukin 22) with hemoglobin A1c levels. Conclusions. Our data reveal that latent infection in the presence of DM or pre-DM, is characterized by diminished production of cytokines, implicated in the control of M. tuberculosis activation, allowing for a potential immunological mechanism that could account for the increased risk of active tuberculosis in latently infected individuals with DM.
JF - Journal of Infectious Diseases
AU - Kumar, Nathella Pavan
AU - George, Parakkal Jovvian
AU - Kumaran, Paul
AU - Dolla, Chandra Kumar
AU - Nutman, Thomas B
AU - Babu, Subash
AD - National Institutes of Health-International Center for Excellence in Research; National Institute for Research in Tuberculosis, sbabu@mail.nih.gov
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
SP - 1670
EP - 1678
PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom
VL - 210
IS - 10
SN - 0022-1899, 0022-1899
KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology
KW - bacterial
KW - cytokines
KW - diabetes
KW - pre-diabetes
KW - tuberculosis
KW - gamma -Interferon
KW - Latent infection
KW - Data processing
KW - Interleukin 2
KW - Interleukin 1
KW - Interleukin 10
KW - Inflammation
KW - Hemoglobin
KW - Diabetes mellitus
KW - Blood
KW - Interleukin 22
KW - Hyperglycemia
KW - Risk factors
KW - Interleukin 18
KW - Cytokines
KW - Tuberculosis
KW - Tumor necrosis factor- alpha
KW - Mycobacterium tuberculosis
KW - J 02350:Immunology
KW - F 06910:Microorganisms & Parasites
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694971749?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Diminished+Systemic+and+Antigen-Specific+Type+1%2C+Type+17%2C+and+Other+Proinflammatory+Cytokines+in+Diabetic+and+Prediabetic+Individuals+With+Latent+Mycobacterium+tuberculosis+Infection&rft.au=Kumar%2C+Nathella+Pavan%3BGeorge%2C+Parakkal+Jovvian%3BKumaran%2C+Paul%3BDolla%2C+Chandra+Kumar%3BNutman%2C+Thomas+B%3BBabu%2C+Subash&rft.aulast=Kumar&rft.aufirst=Nathella&rft.date=2014-11-15&rft.volume=210&rft.issue=10&rft.spage=1670&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu329
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-07-01
N1 - Last updated - 2016-04-13
N1 - SubjectsTermNotLitGenreText - Latent infection; gamma -Interferon; Data processing; Interleukin 2; Interleukin 1; Interleukin 10; Inflammation; Diabetes mellitus; Hemoglobin; Blood; Interleukin 22; Hyperglycemia; Risk factors; Interleukin 18; Cytokines; Tuberculosis; Tumor necrosis factor- alpha; Mycobacterium tuberculosis
DO - http://dx.doi.org/10.1093/infdis/jiu329
ER -
TY - JOUR
T1 - Antigen-Presenting Phagocytic Cells Ingest Malaria Parasites and Increase HIV Replication in a Tumor Necrosis Factor alpha -Dependent Manner
AN - 1694971070; PQ0001607943
AB - Background. Plasmodium falciparum infection induces human immunodeficiency virus (HIV) replication and accelerates a decline in CD4 super(+) T-cell count. The mechanisms contributing to these interactions have not been fully elucidated. Methods. We infected peripheral blood mononuclear cells (PBMCs) with HIV type 1 (HIV-1) and then cocultured them with P. falciparum-infected red blood cells (iRBCs) or uninfected RBCs (uRBCs). Levels of HIV-1 p24 antigen and activation-associated cytokines were measured in culture supernatants. T-cell surface activation was assessed by flow cytometry. Results. It has been reported that iRBCs increase HIV replication, compared with uRBCs; that neutralizing tumor necrosis factor alpha (TNF- alpha ) abrogates this increase; and that hemozoin enhances HIV production. In this study, we confirmed that TNF- alpha plays an important role in this interaction. We show that iRBCs increased CD4 super(+) T-cell expression of HLA-DR super(+)/CD38 super(+) (P = .001), that monocyte/macrophage depletion reduced HIV production by 40%-50% (P < .001), and that hemozoin-laden monocytes/macrophages that were preincubated with iRBCs also stimulated HIV production. Conclusions. iRBCs activate CD4 super(+) T cells and stimulate HIV replication in a TNF- alpha -dependent manner following malarial antigen processing by monocytes/macrophages. These results suggest that the persistent elevation of HIV replication during and after acute bouts of P. falciparum malaria may be due, at least in part, to ongoing stimulation of CD4 super(+) T cells by hemozoin-loaded antigen-presenting cells within lymphoid tissues.
JF - Journal of Infectious Diseases
AU - Orlovi, Marika
AU - Vaida, Florin
AU - Williamson, Kathryn
AU - Deng, Qianqian
AU - Smith, David M
AU - Duffy, Patrick E
AU - Schooley, Robert T
AD - University of California-San Diego, La Jolla; Seattle Biomedical Research Institute, Washington, duffype@niaid.nih.gov
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
SP - 1562
EP - 1572
PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom
VL - 210
IS - 10
SN - 0022-1899, 0022-1899
KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology
KW - HIV
KW - P. falciparum
KW - interaction
KW - mechanism of increased viral load
KW - malaria
KW - co-infection
KW - Histocompatibility antigen HLA
KW - Macrophages
KW - Parasites
KW - hemozoin
KW - Human diseases
KW - Erythrocytes
KW - Cell culture
KW - Malaria
KW - Infection
KW - Public health
KW - Flow cytometry
KW - CD4 antigen
KW - Peripheral blood mononuclear cells
KW - Antigens
KW - Infectious diseases
KW - Phagocytes
KW - Human immunodeficiency virus 1
KW - Lymphocytes T
KW - Cytokines
KW - Antigen processing
KW - Antigen-presenting cells
KW - Monocytes
KW - p24 protein
KW - Replication
KW - Plasmodium falciparum
KW - Tumors
KW - Lymphoid tissue
KW - Human immunodeficiency virus
KW - Tumor necrosis factor- alpha
KW - Tumours
KW - H 6000:Natural Disasters/Civil Defense/Emergency Management
KW - V 22360:AIDS and HIV
KW - K 03400:Human Diseases
KW - Q1 08604:Stock assessment and management
KW - F 06910:Microorganisms & Parasites
KW - Q5 08524:Public health, medicines, dangerous organisms
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-07-01
N1 - Last updated - 2016-10-12
N1 - SubjectsTermNotLitGenreText - Flow cytometry; Macrophages; Parasites; Human diseases; Antigens; Replication; Malaria; Tumours; Public health; Histocompatibility antigen HLA; p24 protein; hemozoin; Erythrocytes; Cell culture; Infection; Lymphoid tissue; Peripheral blood mononuclear cells; CD4 antigen; Phagocytes; Lymphocytes T; Cytokines; Antigen processing; Tumor necrosis factor- alpha; Monocytes; Antigen-presenting cells; Infectious diseases; Human immunodeficiency virus; Tumors; Human immunodeficiency virus 1; Plasmodium falciparum
DO - http://dx.doi.org/10.1093/infdis/jiu317
ER -
TY - CPAPER
T1 - Non-apoptotic functions of the mitochondria-caspase cascade at pre- and post-synaptic sites
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647640155; 6326285
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Li, Z.
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Mitochondria
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L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={54C85D94-6D69-4B09-AFAA-502C0E680CA7}
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - PET imaging of translocator protein, a neuroinflammatory biomarker, in vivo in patients with temporal lobe epilepsy
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647639556; 6326205
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Dickstein, L
AU - Zanotti-Fregonara, P
AU - Dustin, I
AU - Hong, J
AU - Liow, J
AU - Pike, V
AU - Zoghbi, S
AU - Innis, R
AU - Theodore, W
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Temporal lobe
KW - Bioindicators
KW - Epilepsy
KW - Positron emission tomography
KW - Biomarkers
KW - biomarkers
KW - Imaging techniques
KW - Inflammation
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647639556?accountid=14244
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L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={54C85D94-6D69-4B09-AFAA-502C0E680CA7}
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Neuron and astroglia preserve microglial endotoxin tolerance through macrophage colony-stimulating factor
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647639535; 6325946
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Chu, C
AU - Wang, S
AU - Wang, Q
AU - Chen, S
AU - Gao, H
AU - Lu, R.
AU - Hong, J
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Macrophages
KW - Endotoxins
KW - Astrocytes
KW - Neurons
KW - Macrophage colony-stimulating factor
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L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={54C85D94-6D69-4B09-AFAA-502C0E680CA7}
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Neural encoding of the immediate and future value of novel choice options in amygdala, ventral striatum, and orbitofrontal cortex
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647639471; 6326260
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Costa, V
AU - Kakalios, L
AU - Averbeck, B
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Cortex
KW - Neostriatum
KW - Amygdala
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L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={54C85D94-6D69-4B09-AFAA-502C0E680CA7}
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Development of the intrinsic functional connectivity of reward and salience circuitries
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647639445; 6326424
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Ernst, M
AU - Benson, B
AU - Kundru, P
AU - Luh, W
AU - Bandettini, P
AU - Pine, D
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Reinforcement
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647639445?accountid=14244
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L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={54C85D94-6D69-4B09-AFAA-502C0E680CA7}
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Irreproducible results? NIH perspectives on the causes and solutions
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647639368; 6326146
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Collins, F
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Nervous sytems
KW - Neuroscience
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L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={54C85D94-6D69-4B09-AFAA-502C0E680CA7}
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Heat responses in larval zebrafish: escape, thermotaxis and arousal
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647639332; 6326392
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Yokogawa, T
AU - Iadarola, M
AU - Burgess, H
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Heat
KW - Arousal
KW - Larvae
KW - Thermotaxis
KW - Freshwater fish
KW - Danio rerio
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L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={54C85D94-6D69-4B09-AFAA-502C0E680CA7}
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - ALS and C9orf72 in the genomics age: Facts, uncertainties, and the way forward
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647638088; 6326000
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Traynor, B
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Age
KW - Amyotrophic lateral sclerosis
KW - genomics
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L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={54C85D94-6D69-4B09-AFAA-502C0E680CA7}
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - CPAPER
T1 - Trajectory-based processing reflected in slow cortical potentials and fMRI signals
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647637945; 6325991
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - He, B.
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Cortex
KW - Functional magnetic resonance imaging
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T1 - Rapid and continuous activity-dependent plasticity of sensory input to the mouse olfactory bulb in vivo
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647637843; 6325896
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Cheetham, C
AU - Belluscio, L
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Plasticity
KW - Olfactory bulb
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T1 - Exercise and the functional integration of new neurons into the hippocampus
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647635323; 6326629
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - van Praag, H
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Integration
KW - Hippocampus
KW - Neurons
KW - Physical training
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T1 - Sensorimotor predictive coding in the auditory cortex during vocal production in the macaque monkey
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647635027; 6326545
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Fukushima, M
AU - Mullarkey, M
AU - Doyle, A
AU - Saunders, R
AU - Fujii, N
AU - Averbeck, B
AU - Mishkin, M
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Prediction
KW - Coding
KW - sensorimotor system
KW - Cortex (auditory)
KW - Macaca
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T1 - Resting functional connectivity of the extended amygdala
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647634966; 6327246
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Torrisi, S
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Amygdala
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T1 - Mechanisms of polarized sorting in neurons
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647634944; 6326796
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Bonifacino, J
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Neurons
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T1 - Functional role of pre-Botzinger complex excitatory neurons in respiratory rhythm generation: Optogenetic studies
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647634871; 6327214
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Koizumi, H
AU - Koshiya, N
AU - Zhang, R
AU - Mosher, B
AU - Smith, J
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Optics
KW - Genetics
KW - Information processing
KW - Neurons
KW - Respiration
KW - Rhythms
KW - Metabolism
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T1 - Object information in hippocampus and visual cortex during perception and retrieval from long-term memory
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647634056; 6326925
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Lee, S
AU - King, M
AU - Kravitz, D
AU - Baker, C
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Cortex (visual)
KW - Hippocampus
KW - Long term memory
KW - Perception
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N1 - Date revised - 2014-12-31
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T1 - Face-selective regions of the marmoset extrastriate visual cortex - revealed by fMRI & electrocorticography
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647634035; 6326886
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Hung, C
AU - Yen, C
AU - Ciuchta, J
AU - Day-Cooney, J
AU - Papoti, D
AU - Bock, N
AU - Russ, B
AU - Leopold, D
AU - Silva, A
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Cortex (visual)
KW - Functional magnetic resonance imaging
KW - Callithrix
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N1 - Date revised - 2014-12-31
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T1 - Profound putamen catecholamine depletion in Gaucher/Parkinson disease: Role of decreased vesicular sequestration
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647633913; 6326524
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Goldstein, D
AU - Sullivan, P
AU - Tayebi, N
AU - Aflaki, E
AU - Sidransky, E
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Neurodegenerative diseases
KW - Catecholamines
KW - Movement disorders
KW - Parkinson's disease
KW - Putamen
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N1 - Date revised - 2014-12-31
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T1 - Transient inactivation of basal forebrain subregions shapes spontaneous fMRI correlations in the macaque
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647633667; 6326643
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Turchi, J
AU - Chang, C
AU - Monosov, I
AU - Smith, K
AU - Yu, D.
AU - Ye, F.
AU - Zhu, C
AU - Cortes, C
AU - Mishkin, M
AU - Duyn, J
AU - Leopold, D
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Inactivation
KW - Forebrain (basal)
KW - Functional magnetic resonance imaging
KW - Macaca
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N1 - Date revised - 2014-12-31
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T1 - Transgenic marmoset models of brain function and cerebrovascular disorders
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647633641; 6327114
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Silva, A
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Cerebrovascular diseases
KW - Brain
KW - Models
KW - Callithrix
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N1 - Date revised - 2014-12-31
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T1 - Intersectional genetic strategies to unravel the function of the LC/NE system during embryonic development
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647633603; 6326960
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Jensen, P
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Embryogenesis
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N1 - Date revised - 2014-12-31
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T1 - Electrophysiological and behavioral contributions to the resting-state fMRI signal
T2 - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AN - 1647633523; 6326642
JF - 44th Annual Meeting of the Society for Neuroscience (Neuroscience 2014)
AU - Chang, C
AU - Leopold, D
AU - Scholvinck, M
AU - Liu, X
AU - Mandelkow, H
AU - Duyn, J
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
KW - Functional magnetic resonance imaging
KW - Electrophysiology
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L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={54C85D94-6D69-4B09-AFAA-502C0E680CA7}
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-31
N1 - Last updated - 2015-01-23
ER -
TY - JOUR
T1 - Phase I trial of bortezomib (PS-341; NSC 681239) and "nonhybrid" (bolus) infusion schedule of alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory indolent B-cell neoplasms.
AN - 1625343809; 25248382
AB - This phase I study was conducted to determine the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) for the combination of bortezomib and alvocidib in patients with B-cell malignancies (multiple myeloma, indolent lymphoma, Waldenstrom macroglobulinemia, and mantle cell lymphoma).
Patients received bortezomib (intravenous push), followed by alvocidib (1-hour infusion), on days 1, 4, 8, and 11 of a 21-day treatment cycle. Patients experiencing responses or stable disease continued on treatment at the investigator's discretion. A standard 3+3 dose-escalation design was used to identify the MTD based on DLTs, and pharmacokinetic and pharmacodynamic studies were conducted.
A total of 44 patients were enrolled, with 39 patients assessed for response. The MTD was established as 1.3 mg/m(2) for bortezomib and 40 mg/m(2) for alvocidib. The most common hematologic toxicities included leukopenia, lymphopenia, neutropenia, and thrombocytopenia. The most common nonhematologic toxicities included diarrhea, fatigue, and sensory neuropathy. Three complete remissions (8%) and 10 partial remissions (26%) were observed for a total response rate of 33%. Pharmacokinetic findings with the current dosing regimen were consistent with the comparable literature and the hybrid dosing regimen. Pharmacodynamic study results did not correlate with clinical responses. The combination of bortezomib and alvocidib is tolerable, and an MTD has been established for this schedule. The regimen appears to be efficacious in patients with relapsed/refractory multiple myeloma or indolent non-Hodgkin lymphoma. As the nonhybrid regimen is less cumbersome than the previous hybrid dosing schedule regimen, the current schedule is recommended for successor studies.
©2014 American Association for Cancer Research.
JF - Clinical cancer research : an official journal of the American Association for Cancer Research
AU - Holkova, Beata
AU - Kmieciak, Maciej
AU - Perkins, E Brent
AU - Bose, Prithviraj
AU - Baz, Rachid C
AU - Roodman, G David
AU - Stuart, Robert K
AU - Ramakrishnan, Viswanathan
AU - Wan, Wen
AU - Peer, Cody J
AU - Dawson, Jana
AU - Kang, Loveleen
AU - Honeycutt, Connie
AU - Tombes, Mary Beth
AU - Shrader, Ellen
AU - Weir-Wiggins, Caryn
AU - Wellons, Martha
AU - Sankala, Heidi
AU - Hogan, Kevin T
AU - Colevas, A Dimitrios
AU - Doyle, L Austin
AU - Figg, William D
AU - Coppola, Domenico
AU - Roberts, John D
AU - Sullivan, Daniel
AU - Grant, Steven
AD - Massey Cancer Center and Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia. bholkova@mcvh-vcu.edu. ; Massey Cancer Center and. ; Massey Cancer Center and Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia. ; Chemical Biology and Molecular Medicine Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida. ; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. ; Department of Medicine, Medical University of South Carolina, Charleston, South Carolina. ; Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia. ; Center for Cancer Research, NCI, NIH, Bethesda, Maryland. ; James A. Haley Veterans' Hospital, Tampa, Florida. ; Cancer Therapy Evaluation Program, NCI, NIH, Bethesda, Maryland. Departments of. ; Massey Cancer Center and Massey Cancer Center and Massey Cancer Center and Massey Cancer Center and Massey Cancer Center and.
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
SP - 5652
EP - 5662
VL - 20
IS - 22
SN - 1078-0432, 1078-0432
KW - Boronic Acids
KW - 0
KW - Flavonoids
KW - Piperidines
KW - Pyrazines
KW - alvocidib
KW - 45AD6X575G
KW - Bortezomib
KW - 69G8BD63PP
KW - Index Medicus
KW - Drug Administration Schedule
KW - Combined Modality Therapy
KW - Humans
KW - Piperidines -- pharmacokinetics
KW - Aged
KW - Boronic Acids -- pharmacokinetics
KW - Recurrence
KW - Pyrazines -- pharmacokinetics
KW - Flavonoids -- administration & dosage
KW - Pyrazines -- administration & dosage
KW - Boronic Acids -- administration & dosage
KW - Adult
KW - Drug Monitoring
KW - Treatment Outcome
KW - Piperidines -- administration & dosage
KW - Middle Aged
KW - Flavonoids -- pharmacokinetics
KW - Retreatment
KW - Male
KW - Female
KW - Lymphoproliferative Disorders -- diagnosis
KW - Lymphoproliferative Disorders -- drug therapy
KW - B-Lymphocytes -- pathology
KW - Lymphoproliferative Disorders -- pathology
KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects
KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-09
N1 - Date created - 2014-11-15
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-0805
ER -
TY - JOUR
T1 - Epigenetic control of Ccr7 expression in distinct lineages of lung dendritic cells.
AN - 1622066632; 25297875
AB - Adaptive immune responses to inhaled allergens are induced following CCR7-dependent migration of precursor of dendritic cell (pre-DC)-derived conventional DCs (cDCs) from the lung to regional lymph nodes. However, monocyte-derived (moDCs) in the lung express very low levels of Ccr7 and consequently do not migrate efficiently to LN. To investigate the molecular mechanisms that underlie this dichotomy, we studied epigenetic modifications at the Ccr7 locus of murine cDCs and moDCs. When expanded from bone marrow precursors, moDCs were enriched at the Ccr7 locus for trimethylation of histone 3 lysine 27 (H3K27me3), a modification associated with transcriptional repression. Similarly, moDCs prepared from the lung also displayed increased levels of H3K27me3 at the Ccr7 promoter compared with migratory cDCs from that organ. Analysis of DC progenitors revealed that epigenetic modification of Ccr7 does not occur early during DC lineage commitment because monocytes and pre-DCs both had low levels of Ccr7-associated H3K27me3. Rather, Ccr7 is gradually silenced during the differentiation of monocytes to moDCs. Thus, epigenetic modifications of the Ccr7 locus control the migration and therefore the function of DCs in vivo. These findings suggest that manipulating epigenetic mechanisms might be a novel approach to control DC migration and thereby improve DC-based vaccines and treat inflammatory diseases of the lung. Copyright © 2014 by The American Association of Immunologists, Inc.
JF - Journal of immunology (Baltimore, Md. : 1950)
AU - Moran, Timothy P
AU - Nakano, Hideki
AU - Kondilis-Mangum, Hrisavgi D
AU - Wade, Paul A
AU - Cook, Donald N
AD - Department of Pediatrics, Duke University Medical Center, Durham, NC 27710; ; Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709; and. ; Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709. ; Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709; and cookd@niehs.nih.gov.
Y1 - 2014/11/15/
PY - 2014
DA - 2014 Nov 15
SP - 4904
EP - 4913
VL - 193
IS - 10
KW - Ccr7 protein, mouse
KW - 0
KW - Histones
KW - Receptors, CCR7
KW - Abridged Index Medicus
KW - Index Medicus
KW - Cell Movement
KW - Animals
KW - Primary Cell Culture
KW - Cell Differentiation
KW - Transcription, Genetic
KW - Bone Marrow Cells -- immunology
KW - Mice
KW - Cell Proliferation
KW - Mice, Transgenic
KW - Cell Lineage -- immunology
KW - Lymph Nodes -- cytology
KW - Promoter Regions, Genetic
KW - Bone Marrow Cells -- cytology
KW - Methylation
KW - Signal Transduction
KW - Lymph Nodes -- immunology
KW - Lung -- immunology
KW - Receptors, CCR7 -- immunology
KW - Dendritic Cells -- immunology
KW - Monocytes -- cytology
KW - Histones -- immunology
KW - Monocytes -- immunology
KW - Lung -- cytology
KW - Epigenesis, Genetic
KW - Dendritic Cells -- cytology
KW - Histones -- genetics
KW - Receptors, CCR7 -- genetics
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-24
N1 - Date created - 2014-11-08
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.4049/jimmunol.1401104
ER -
TY - JOUR
T1 - DNA recombination. Recombination initiation maps of individual human genomes.
AN - 1625345774; 25395542
AB - DNA double-strand breaks (DSBs) are introduced in meiosis to initiate recombination and generate crossovers, the reciprocal exchanges of genetic material between parental chromosomes. Here, we present high-resolution maps of meiotic DSBs in individual human genomes. Comparing DSB maps between individuals shows that along with DNA binding by PRDM9, additional factors may dictate the efficiency of DSB formation. We find evidence for both GC-biased gene conversion and mutagenesis around meiotic DSB hotspots, while frequent colocalization of DSB hotspots with chromosome rearrangement breakpoints implicates the aberrant repair of meiotic DSBs in genomic disorders. Furthermore, our data indicate that DSB frequency is a major determinant of crossover rate. These maps provide new insights into the regulation of meiotic recombination and the impact of meiotic recombination on genome function.
Copyright © 2014, American Association for the Advancement of Science.
JF - Science (New York, N.Y.)
AU - Pratto, Florencia
AU - Brick, Kevin
AU - Khil, Pavel
AU - Smagulova, Fatima
AU - Petukhova, Galina V
AU - Camerini-Otero, R Daniel
AD - National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA. ; Department of Biochemistry and Molecular Biology, Uniformed Services University of Health Sciences, Bethesda, MD, USA. ; Department of Biochemistry and Molecular Biology, Uniformed Services University of Health Sciences, Bethesda, MD, USA. rdcamerini@mail.nih.gov galina.petukhova@usuhs.edu. ; National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA. rdcamerini@mail.nih.gov galina.petukhova@usuhs.edu.
Y1 - 2014/11/14/
PY - 2014
DA - 2014 Nov 14
SP - 1256442
VL - 346
IS - 6211
KW - Histone-Lysine N-Methyltransferase
KW - EC 2.1.1.43
KW - PRDM9 protein, human
KW - Index Medicus
KW - Histone-Lysine N-Methyltransferase -- genetics
KW - Alleles
KW - Humans
KW - Telomere -- genetics
KW - Protein Binding
KW - Histone-Lysine N-Methyltransferase -- metabolism
KW - Spermatocytes
KW - Male
KW - Homologous Recombination
KW - Genomic Instability
KW - Meiosis -- genetics
KW - Genome, Human -- genetics
KW - DNA Breaks, Double-Stranded
KW - Chromosome Mapping
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=DNA+recombination.+Recombination+initiation+maps+of+individual+human+genomes.&rft.au=Pratto%2C+Florencia%3BBrick%2C+Kevin%3BKhil%2C+Pavel%3BSmagulova%2C+Fatima%3BPetukhova%2C+Galina+V%3BCamerini-Otero%2C+R+Daniel&rft.aulast=Pratto&rft.aufirst=Florencia&rft.date=2014-11-14&rft.volume=346&rft.issue=6211&rft.spage=1256442&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/10.1126%2Fscience.1256442
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-12-04
N1 - Date created - 2014-11-14
N1 - Date revised - 2017-01-14
N1 - Genetic sequence - GSE59836; GEO
N1 - SuppNotes - Comment In:
Science. 2014 Nov 14;346(6211):808-9 [25395519]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1126/science.1256442
ER -
TY - JOUR
T1 - Dual effects of a targeted small-molecule inhibitor (cabozantinib) on immune-mediated killing of tumor cells and immune tumor microenvironment permissiveness when combined with a cancer vaccine.
AN - 1676341169; 25388653
AB - Growing awareness of the complexity of carcinogenesis has made multimodal therapies for cancer increasingly compelling and relevant. In recent years, immunotherapy has gained acceptance as an active therapeutic approach to cancer treatment, even though cancer is widely considered an immunosuppressive disease. Combining immunotherapy with targeted agents that have immunomodulatory capabilities could significantly improve its efficacy.
We evaluated the ability of cabozantinib, a receptor tyrosine kinase inhibitor, to modulate the immune system in vivo as well as alter the phenotype of tumor cells in vitro in order to determine if this inhibitor could act synergistically with a cancer vaccine. Our studies indicated that cabozantinib altered the phenotype of MC38-CEA murine tumor cells, rendering them more sensitive to immune-mediated killing. Cabozantinib also altered the frequency of immune sub-populations in the periphery as well as in the tumor microenvironment, which generated a more permissive immune environment. When cabozantinib was combined with a poxviral-based cancer vaccine targeting a self-antigen, the combination significantly reduced the function of regulatory T cells and increased cytokine production from effector T cells in response to the antigen. These alterations to the immune landscape, along with direct modification of tumor cells, led to markedly improved antitumor efficacy.
These studies support the clinical combination of cabozantinib with immunotherapy for the treatment of cancer.
JF - Journal of translational medicine
AU - Kwilas, Anna R
AU - Ardiani, Andressa
AU - Donahue, Renee N
AU - Aftab, Dana T
AU - Hodge, James W
AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive; Room 8B13, Bethesda, MD, 20892, USA. anna.kwilas@nih.gov. ; Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive; Room 8B13, Bethesda, MD, 20892, USA. smith.andressa.a@gmail.com. ; Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive; Room 8B13, Bethesda, MD, 20892, USA. renee.donahue@nih.gov. ; Exelixis, Inc., South San Francisco, CA, USA. daftab@exelixis.com. ; Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive; Room 8B13, Bethesda, MD, 20892, USA. jh241d@nih.gov.
Y1 - 2014/11/13/
PY - 2014
DA - 2014 Nov 13
SP - 294
VL - 12
KW - Anilides
KW - 0
KW - Biomarkers, Tumor
KW - Cancer Vaccines
KW - Pyridines
KW - Small Molecule Libraries
KW - cabozantinib
KW - 1C39JW444G
KW - Index Medicus
KW - Cell Proliferation -- drug effects
KW - Animals
KW - Combined Modality Therapy
KW - Immunotherapy
KW - Lymphocyte Subsets -- drug effects
KW - Cell Line, Tumor
KW - Mice, Transgenic
KW - Biomarkers, Tumor -- metabolism
KW - Phenotype
KW - Mice, Inbred C57BL
KW - Lymphocyte Subsets -- immunology
KW - T-Lymphocytes -- drug effects
KW - T-Lymphocytes -- immunology
KW - Female
KW - Neoplasms -- drug therapy
KW - Small Molecule Libraries -- therapeutic use
KW - Pyridines -- therapeutic use
KW - Tumor Microenvironment -- drug effects
KW - Anilides -- pharmacology
KW - Cancer Vaccines -- immunology
KW - Anilides -- therapeutic use
KW - Neoplasms -- blood supply
KW - Neoplasms -- pathology
KW - Small Molecule Libraries -- pharmacology
KW - Cytotoxicity, Immunologic -- drug effects
KW - Pyridines -- pharmacology
KW - Neoplasms -- immunology
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676341169?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+translational+medicine&rft.atitle=Dual+effects+of+a+targeted+small-molecule+inhibitor+%28cabozantinib%29+on+immune-mediated+killing+of+tumor+cells+and+immune+tumor+microenvironment+permissiveness+when+combined+with+a+cancer+vaccine.&rft.au=Kwilas%2C+Anna+R%3BArdiani%2C+Andressa%3BDonahue%2C+Renee+N%3BAftab%2C+Dana+T%3BHodge%2C+James+W&rft.aulast=Kwilas&rft.aufirst=Anna&rft.date=2014-11-13&rft.volume=12&rft.issue=&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Journal+of+translational+medicine&rft.issn=1479-5876&rft_id=info:doi/10.1186%2Fs12967-014-0294-y
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2016-03-14
N1 - Date created - 2015-04-27
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
J Clin Oncol. 2011 Jul 1;29(19):2660-6 [21606412]
J Biomed Biotechnol. 2011;2011:165214 [21687596]
Cancer Immunol Immunother. 2011 Sep;60(9):1227-42 [21544650]
Mol Cancer Ther. 2011 Dec;10(12):2298-308 [21926191]
Histol Histopathol. 2012 Feb;27(2):197-207 [22207554]
Cancer Biother Radiopharm. 2012 Feb;27(1):23-35 [22316209]
Int J Cancer. 2012 Apr 15;130(8):1948-59 [21633954]
Cancer Discov. 2012 Mar;2(3):270-87 [22585997]
Semin Oncol. 2012 Jun;39(3):323-39 [22595055]
Oncologist. 2012;17(8):1039-50 [22773560]
J Immunol. 2012 Oct 15;189(8):3789-93 [23042723]
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17561-6 [23045683]
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Future Oncol. 2013 Aug;9(8):1083-92 [23902240]
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Cancer Res. 1991 Jul 15;51(14):3657-62 [1712245]
Cancer Res. 1998 Apr 1;58(7):1469-77 [9537250]
Int J Cancer. 2005 Feb 10;113(4):678-82 [15455388]
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Clin Cancer Res. 2005 Mar 15;11(6):2416-26 [15788693]
J Immunol. 2005 Oct 1;175(7):4745-53 [16177122]
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18538-43 [16344461]
Cancer Res. 2006 Jun 1;66(11):5527-36 [16740684]
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Cancer. 2009 Aug 15;115(16):3670-9 [19536890]
Gastroenterology. 2009 Oct;137(4):1270-9 [19577568]
Anticancer Res. 2009 Nov;29(11):4807-11 [20032439]
Cancer Immunol Immunother. 2010 Mar;59(3):397-408 [19756595]
J Clin Oncol. 2010 Mar 1;28(7):1099-105 [20100959]
Int J Cancer. 2010 Oct 1;127(7):1603-13 [20091862]
N Engl J Med. 2010 Aug 19;363(8):711-23 [20525992]
PLoS One. 2010;5(11):e15384 [21072211]
Cancer Res. 2010 Dec 15;70(24):10090-100 [20952508]
Int J Biochem Cell Biol. 2011 Aug;43(8):1134-46 [21536148]
Cancer Res. 2011 Jul 15;71(14):4758-68 [21613405]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1186/s12967-014-0294-y
ER -
TY - JOUR
T1 - PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling.
AN - 1625342356; 24213576
AB - Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits skin tumorigenesis through mechanisms that may be dependent on HRAS signaling. The present study examined the hypothesis that PPARβ/δ promotes HRAS-induced senescence resulting in suppression of tumorigenesis. PPARβ/δ expression increased p-ERK and decreased p-AKT activity. Increased p-ERK activity results from the dampened HRAS-induced negative feedback response mediated in part through transcriptional upregulation of RAS guanyl-releasing protein 1 (RASGRP1) by PPARβ/δ. Decreased p-AKT activity results from repression of integrin-linked kinase (ILK) and phosphoinositide-dependent protein kinase-1 (PDPK1) expression. Decreased p-AKT activity in turn promotes cellular senescence through upregulation of p53 and p27 expression. Both over-expression of RASGRP1 and shRNA-mediated knockdown of ILK partially restore cellular senescence in Pparβ/δ-null cells. Higher PPARβ/δ expression is also correlated with increased senescence observed in human benign neurofibromas and colon adenoma lesions in vivo. These results demonstrate that PPARβ/δ promotes senescence to inhibit tumorigenesis and provide new mechanistic insights into HRAS-induced cellular senescence.
JF - Oncogene
AU - Zhu, B
AU - Ferry, C H
AU - Blazanin, N
AU - Bility, M T
AU - Khozoie, C
AU - Kang, B-H
AU - Glick, A B
AU - Gonzalez, F J
AU - Peters, J M
AD - Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA. ; Preclinical Research Center, Chemon, Yongin-Si, Korea. ; Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA.
Y1 - 2014/11/13/
PY - 2014
DA - 2014 Nov 13
SP - 5348
EP - 5359
VL - 33
IS - 46
KW - PPAR delta
KW - 0
KW - PPAR-beta
KW - Proto-Oncogene Proteins c-akt
KW - EC 2.7.11.1
KW - Mitogen-Activated Protein Kinase 1
KW - EC 2.7.11.24
KW - Mitogen-Activated Protein Kinase 3
KW - ras Proteins
KW - EC 3.6.5.2
KW - Index Medicus
KW - Aging -- metabolism
KW - Animals
KW - Carcinogenesis -- metabolism
KW - HEK293 Cells
KW - Humans
KW - Skin Neoplasms -- pathology
KW - Mice
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Skin Neoplasms -- metabolism
KW - Cell Aging -- genetics
KW - NIH 3T3 Cells
KW - Mice, Knockout
KW - Skin Neoplasms -- genetics
KW - Blotting, Western
KW - Carcinogenesis -- genetics
KW - Phosphorylation
KW - Cells, Cultured
KW - Keratinocytes -- cytology
KW - Keratinocytes -- metabolism
KW - RNA Interference
KW - Signal Transduction
KW - Aging -- genetics
KW - Female
KW - Mitogen-Activated Protein Kinase 3 -- metabolism
KW - ras Proteins -- genetics
KW - Proto-Oncogene Proteins c-akt -- metabolism
KW - PPAR-beta -- metabolism
KW - PPAR delta -- genetics
KW - Mitogen-Activated Protein Kinase 1 -- metabolism
KW - PPAR-beta -- genetics
KW - ras Proteins -- metabolism
KW - PPAR delta -- metabolism
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1625342356?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=PPAR%CE%B2%2F%CE%B4+promotes+HRAS-induced+senescence+and+tumor+suppression+by+potentiating+p-ERK+and+repressing+p-AKT+signaling.&rft.au=Zhu%2C+B%3BFerry%2C+C+H%3BBlazanin%2C+N%3BBility%2C+M+T%3BKhozoie%2C+C%3BKang%2C+B-H%3BGlick%2C+A+B%3BGonzalez%2C+F+J%3BPeters%2C+J+M&rft.aulast=Zhu&rft.aufirst=B&rft.date=2014-11-13&rft.volume=33&rft.issue=46&rft.spage=5348&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2013.477
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-01-28
N1 - Date created - 2014-11-14
N1 - Date revised - 2017-01-13
N1 - SuppNotes - Cited By:
J Biol Chem. 2011 Sep 23;286(38):33447-56 [21795702]
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Nat Biotechnol. 2010 Dec;28(12):1248-50 [21139605]
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Nature. 1986 Jul 3-9;322(6074):78-80 [3014349]
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Oncogene. 2008 May 1;27(20):2801-9 [18193093]
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Cell. 2008 Jun 13;133(6):1019-31 [18555778]
Clin Sci (Lond). 2008 Aug;115(4):107-27 [18616431]
Cancer Cell. 2008 Aug 12;14(2):146-55 [18691549]
Mol Pharmacol. 2008 Nov;74(5):1429-42 [18687807]
N Engl J Med. 2008 Oct 23;359(17):1757-65 [18946061]
Toxicology. 2008 Dec 5;254(1-2):112-7 [18950674]
Carcinogenesis. 2008 Dec;29(12):2406-14 [18799709]
Cancer Res. 2009 Aug 1;69(15):6299-306 [19602588]
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Nat Protoc. 2009;4(12):1798-806 [20010931]
Toxicol Sci. 2010 Jan;113(1):27-36 [19748995]
EMBO Mol Med. 2009 Jul;1(4):236-48 [20049725]
Oncogene. 2010 Jan 28;29(4):516-26 [19935699]
Gastroenterology. 2010 Feb;138(2):636-48, 648.e1-12 [19818784]
Clin Exp Metastasis. 2010 Feb;27(2):83-90 [20143136]
Nature. 2010 Mar 18;464(7287):374-9 [20237562]
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PLoS One. 2010;5(10). pii: e13091. doi: 10.1371/journal.pone.0013091 [20957034]
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Cancer Res. 2010 Nov 1;70(21):8526-36 [20959475]
Mol Cancer Ther. 2010 Dec;9(12):3267-77 [21159610]
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PLoS One. 2011;6(1):e16344 [21283829]
Mol Cell. 2011 Apr 8;42(1):36-49 [21474066]
Clin Cancer Res. 2011 Jun 1;17(11):3760-70 [21531809]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1038/onc.2013.477
ER -
TY - JOUR
T1 - Cell cycle restriction is more important than apoptosis induction for RASSF1A protein tumor suppression.
AN - 1622066495; 25225292
AB - The Ras association domain family protein 1A (RASSF1A) is arguably one of the most frequently inactivated tumor suppressors in human cancer. RASSF1A modulates apoptosis via the Hippo and Bax pathways but also modulates the cell cycle. In part, cell cycle regulation appears to be dependent upon the ability of RASSF1A to complex with microtubules and regulate their dynamics. Which property of RASSF1A, apoptosis induction or microtubule regulation, is responsible for its tumor suppressor function is not known. We have identified a short conserved motif that is essential for the binding of RASSF family proteins with microtubule-associated proteins. By making a single point mutation in the motif, we were able to generate a RASSF1A variant that retains wild-type apoptotic properties but completely loses the ability to bind microtubule-associated proteins and complex with microtubules. Comparison of this mutant to wild-type RASSF1A showed that, despite retaining its proapoptotic properties, the mutant was completely unable to induce cell cycle arrest or suppress the tumorigenic phenotype. Therefore, it appears that the cell cycle/microtubule effects of RASSF1A are key to its tumor suppressor function rather than its apoptotic effects.
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
JF - The Journal of biological chemistry
AU - Donninger, Howard
AU - Clark, Jennifer A
AU - Monaghan, Megan K
AU - Schmidt, M Lee
AU - Vos, Michele
AU - Clark, Geoffrey J
AD - From the Departments of Medicine. ; Biochemistry and Molecular Biology, and. ; the Cell and Cancer Biology Branch, NCI, National Institutes of Health, Rockville, Maryland 20850. ; Pharmacology and Toxicology, James Graham Brown Cancer Center, Molecular Targets Program, University of Louisville, Louisville, Kentucky 40202 and gjclar01@louisville.edu.
Y1 - 2014/11/07/
PY - 2014
DA - 2014 Nov 07
SP - 31287
EP - 31295
VL - 289
IS - 45
KW - RASSF1 protein, human
KW - 0
KW - Tumor Suppressor Proteins
KW - Green Fluorescent Proteins
KW - 147336-22-9
KW - ras Proteins
KW - EC 3.6.5.2
KW - Index Medicus
KW - Ras
KW - Oncogene
KW - Ras Protein
KW - Tumor Suppressor
KW - Apoptosis
KW - Cell Cycle
KW - Microtubule-associated Protein (MAP)
KW - Animals
KW - COS Cells
KW - HEK293 Cells
KW - Humans
KW - Amino Acid Sequence
KW - Cell Line, Tumor
KW - Phenotype
KW - Amino Acid Motifs
KW - Cercopithecus aethiops
KW - Point Mutation
KW - Molecular Sequence Data
KW - ras Proteins -- metabolism
KW - Sequence Homology, Amino Acid
KW - Green Fluorescent Proteins -- metabolism
KW - Mutation
KW - Tumor Suppressor Proteins -- metabolism
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622066495?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Cell+cycle+restriction+is+more+important+than+apoptosis+induction+for+RASSF1A+protein+tumor+suppression.&rft.au=Donninger%2C+Howard%3BClark%2C+Jennifer+A%3BMonaghan%2C+Megan+K%3BSchmidt%2C+M+Lee%3BVos%2C+Michele%3BClark%2C+Geoffrey+J&rft.aulast=Donninger&rft.aufirst=Howard&rft.date=2014-11-07&rft.volume=289&rft.issue=45&rft.spage=31287&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M114.609537
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-01-17
N1 - Date created - 2014-11-08
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Oncogene. 2002 Feb 21;21(9):1381-90 [11857081]
Methods Enzymol. 2001;332:3-36 [11305105]
Nat Cell Biol. 2004 Feb;6(2):129-37 [14743218]
Cancer Res. 2004 Jun 15;64(12):4112-6 [15205320]
J Natl Cancer Inst. 2001 May 2;93(9):691-9 [11333291]
Cancer Res. 2004 Jun 15;64(12):4244-50 [15205337]
Front Biosci. 1998 Aug 6;3:d887-912 [9696882]
Oncogene. 2004 Oct 28;23(50):8216-30 [15378022]
J Biol Chem. 1995 Sep 15;270(37):21695-700 [7665586]
J Biol Chem. 1997 Nov 28;272(48):30362-70 [9374526]
Histol Histopathol. 2005 Apr;20(2):645-63 [15736067]
Cancer Res. 2005 Mar 1;65(5):1830-8 [15753381]
Cancer Res. 2005 May 1;65(9):3497-508 [15867337]
Biochem Biophys Res Commun. 2005 Jul 8;332(3):670-6 [15907802]
Mol Cell. 2005 Jun 10;18(6):637-50 [15949439]
Exp Cell Res. 2005 Aug 15;308(2):446-58 [15936015]
J Biol Chem. 2006 Feb 24;281(8):4557-63 [16344548]
Methods Enzymol. 2006;407:290-310 [16757333]
Cancer Res. 2007 Jan 15;67(2):492-500 [17234756]
Curr Biol. 2007 Apr 17;17(8):700-5 [17379520]
Biochim Biophys Acta. 2007 Sep;1776(1):58-85 [17692468]
J Cell Sci. 2007 Sep 15;120(Pt 18):3163-72 [17878233]
Mol Cell. 2007 Sep 21;27(6):962-75 [17889669]
Oncogene. 2007 Dec 6;26(55):7700-8 [17563743]
Biol Chem. 2008 Jan;389(1):57-67 [18095870]
EMBO J. 2008 Jul 23;27(14):1995-2005 [18596699]
Mol Cell Neurosci. 2009 Jan;40(1):111-9 [19013529]
Mol Cell Biol. 2009 Mar;29(5):1338-53 [19114553]
Cancer Res. 2009 Mar 1;69(5):1748-57 [19223555]
Oncogene. 2009 Aug 20;28(33):2988-98 [19525978]
Oncogene. 2010 Oct 21;29(42):5729-40 [20697344]
J Biol Chem. 2011 May 27;286(21):18483-91 [21489991]
Mol Cell. 2011 Dec 23;44(6):893-906 [22195963]
Mol Biol Cell. 2014 Mar;25(6):800-10 [24478455]
Nat Genet. 2000 Jul;25(3):315-9 [10888881]
J Biol Chem. 2000 Nov 17;275(46):35669-72 [10998413]
J Biol Chem. 2000 Dec 29;275(52):41251-7 [11007785]
Oncogene. 2003 Nov 6;22(50):8125-36 [14603253]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1074/jbc.M114.609537
ER -
TY - JOUR
T1 - Substrate-induced DNA polymerase β activation.
AN - 1622065096; 25261471
AB - DNA polymerases and substrates undergo conformational changes upon forming protein-ligand complexes. These conformational adjustments can hasten or deter DNA synthesis and influence substrate discrimination. From structural comparison of binary DNA and ternary DNA-dNTP complexes of DNA polymerase β, several side chains have been implicated in facilitating formation of an active ternary complex poised for chemistry. Site-directed mutagenesis of these highly conserved residues (Asp-192, Arg-258, Phe-272, Glu-295, and Tyr-296) and kinetic characterization provides insight into the role these residues play during correct and incorrect insertion as well as their role in conformational activation. The catalytic efficiencies for correct nucleotide insertion for alanine mutants were wild type ∼ R258A > F272A ∼ Y296A > E295A > D192A. Because the efficiencies for incorrect insertion were affected to about the same extent for each mutant, the effects on fidelity were modest (<5-fold). The R258A mutant exhibited an increase in the single-turnover rate of correct nucleotide insertion. This suggests that the wild-type Arg-258 side chain generates a population of non-productive ternary complexes. Structures of binary and ternary substrate complexes of the R258A mutant and a mutant associated with gastric carcinomas, E295K, provide molecular insight into intermediate structural conformations not appreciated previously. Although the R258A mutant crystal structures were similar to wild-type enzyme, the open ternary complex structure of E295K indicates that Arg-258 stabilizes a non-productive conformation of the primer terminus that would decrease catalysis. Significantly, the open E295K ternary complex binds two metal ions indicating that metal binding cannot overcome the modified interactions that have interrupted the closure of the N-subdomain.
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
JF - The Journal of biological chemistry
AU - Beard, William A
AU - Shock, David D
AU - Batra, Vinod K
AU - Prasad, Rajendra
AU - Wilson, Samuel H
AD - From the Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709. ; From the Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 wilson5@niehs.nih.gov.
Y1 - 2014/11/07/
PY - 2014
DA - 2014 Nov 07
SP - 31411
EP - 31422
VL - 289
IS - 45
KW - Nucleotides
KW - 0
KW - DNA Polymerase beta
KW - EC 2.7.7.-
KW - Lysine
KW - K3Z4F929H6
KW - Alanine
KW - OF5P57N2ZX
KW - Index Medicus
KW - Enzyme Mechanism
KW - X-ray Crystallography
KW - Conformational Change
KW - DNA Polymerase
KW - Mutagenesis
KW - Mutagenesis, Site-Directed
KW - Lysine -- chemistry
KW - Humans
KW - Catalytic Domain
KW - Nucleotides -- chemistry
KW - Crystallography, X-Ray
KW - Alanine -- chemistry
KW - Substrate Specificity
KW - Protein Binding
KW - Mutation
KW - Hydrogen Bonding
KW - Catalysis
KW - DNA Polymerase beta -- genetics
KW - DNA Polymerase beta -- chemistry
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622065096?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Substrate-induced+DNA+polymerase+%CE%B2+activation.&rft.au=Beard%2C+William+A%3BShock%2C+David+D%3BBatra%2C+Vinod+K%3BPrasad%2C+Rajendra%3BWilson%2C+Samuel+H&rft.aulast=Beard&rft.aufirst=William&rft.date=2014-11-07&rft.volume=289&rft.issue=45&rft.spage=31411&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M114.607432
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-01-17
N1 - Date created - 2014-11-08
N1 - Date revised - 2017-01-14
N1 - Genetic sequence - 4R63; PDB; 4R65; 4R64; 4R66
N1 - SuppNotes - Cited By:
Biochemistry. 1997 Feb 4;36(5):1100-7 [9033400]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1074/jbc.M114.607432
ER -
TY - JOUR
T1 - Epidemiology of Dengue Disease in the Philippines (2000-2011): A Systematic Literature Review
AN - 1642617607; 21084600
AB - This literature analysis describes the available dengue epidemiology data in the Philippines between 2000 and 2011. Of 253 relevant data sources identified, 34, including additional epidemiology data provided by the National Epidemiology Center, Department of Health, Philippines, were reviewed. There were 14 publications in peer reviewed journals, and 17 surveillance reports/sources, which provided variable information from the passive reporting system and show broad trends in dengue incidence, including age group predominance and disease severity. The peer reviewed studies focused on clinical severity of cases, some revealed data on circulating serotypes and genotypes and on the seroepidemiology of dengue including incidence rates for infection and apparent disease. Gaps in the data were identified, and include the absence incidence rates stratified by age, dengue serotype and genotype distribution, disease severity data, sex distribution data, and seroprevalence data. Dengue disease is a tropical and subtropical mosquito-borne viral illness and is a major health concern in the Philippines. To determine the dengue disease burden in the Philippines and identify gaps and future research needs, we conducted a literature analysis and review to describe the epidemiology of dengue disease. We used well-defined methods to search and identify relevant research conducted between 2000 and 2011. This long-term review highlights an increase in the reported incidence of dengue disease in the Philippines. The rising incidence of dengue disease may be related to a growing population, increasing urbanization, improvements in surveillance, and the limited success of vector control measures. Gaps in the epidemiological information available in the Philippines during the period 2000-2011 include comprehensive national and regional data that describe the proportion of severe dengue disease, including hospitalizations and mortality, and incidence data per 100,000 population. More comprehensive data are also needed for age, serotype, and seroprevalence on both national and regional levels. The data presented enable the observation of epidemiological characteristics, both within and across years. Such assessments are essential at national and regional levels to improve both preparedness and response activities relating to dengue disease outbreaks.
JF - PLoS Neglected Tropical Diseases
AU - Bravo, Lulu
AU - Roque, Vito G
AU - Brett, Jeremy
AU - Dizon, Ruby
AU - L'Azou, Maina
AD - National Institutes of Health, University of the Philippines Manila (UPM), Manila, Philippines
Y1 - 2014/11/06/
PY - 2014
DA - 2014 Nov 06
PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States
VL - 8
IS - 11
SN - 1935-2727, 1935-2727
KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources
KW - Philippines
KW - Age
KW - Human diseases
KW - Serotypes
KW - Urbanization
KW - Genotypes
KW - Infection
KW - Public health
KW - Disease transmission
KW - ISEW, Philippines
KW - Dengue
KW - Seroepidemiology
KW - Sex
KW - Mortality
KW - Data processing
KW - Surveillance and enforcement
KW - Vectors
KW - Literature reviews
KW - Epidemiology
KW - Viral diseases
KW - Reviews
KW - Outbreaks
KW - Mortality causes
KW - V 22410:Animal Diseases
KW - Q1 08604:Stock assessment and management
KW - H 12000:Epidemiology and Public Health
KW - Q5 08524:Public health, medicines, dangerous organisms
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642617607?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Epidemiology+of+Dengue+Disease+in+the+Philippines+%282000-2011%29%3A+A+Systematic+Literature+Review&rft.au=Bravo%2C+Lulu%3BRoque%2C+Vito+G%3BBrett%2C+Jeremy%3BDizon%2C+Ruby%3BL%27Azou%2C+Maina&rft.aulast=Bravo&rft.aufirst=Lulu&rft.date=2014-11-06&rft.volume=8&rft.issue=11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0003027
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-01-01
N1 - Last updated - 2016-12-22
N1 - SubjectsTermNotLitGenreText - Human diseases; Viral diseases; Urbanization; Epidemiology; Surveillance and enforcement; Genotypes; Mortality causes; Disease transmission; Public health; Mortality; Age; Data processing; Serotypes; Vectors; Infection; Literature reviews; Dengue; Reviews; Seroepidemiology; Sex; Outbreaks; Philippines; ISEW, Philippines
DO - http://dx.doi.org/10.1371/journal.pntd.0003027
ER -
TY - JOUR
T1 - Coincident Helminth Infection Modulates Systemic Inflammation and Immune Activation in Active Pulmonary Tuberculosis
AN - 1639474579; 21084608
AB - Helminth-induced changes in the immune system are thought to influence the outcome of secondary infections. Approximately 50-100 million people are thought to have infection by worms known as Strongyloides stercoralis, while more than 2 billion people worldwide are infected with the bacterium, Mycobacterium tuberculosis. Interestingly, there is a great degree of overlap in the geographical spread of both infections. We and others have previously shown that helminth infections induce modulation of innate and adaptive immune responses in tuberculosis. In this study, we examined whether concomitant helminth infection has a secondary effect on systemic markers of disease severity/activity in pulmonary tuberculosis. We show that helminth infection have profound effect on lowering most of the circulating parameters associated with tuberculosis pathology. We therefore, conclude that helminth infections have both beneficial and detrimental effects on the progression of tuberculosis, with the beneficial effect manifest upon development of pathology.
JF - PLoS Neglected Tropical Diseases
AU - George, Parakkal Jovvian
AU - Kumar, Nathella Pavan
AU - Sridhar, Rathinam
AU - Hanna, Luke E
AU - Nair, Dina
AU - Banurekha, Vaithilingam V
AU - Nutman, Thomas B
AU - Babu, Subash
AD - National Institutes of Health-NIRT-International Center for Excellence in Research, Chennai, India
Y1 - 2014/11/06/
PY - 2014
DA - 2014 Nov 06
PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States
VL - 8
IS - 11
SN - 1935-2727, 1935-2727
KW - Microbiology Abstracts B: Bacteriology
KW - Strongyloides stercoralis
KW - Lung
KW - Immune system
KW - Tuberculosis
KW - Immune response
KW - Secondary infection
KW - Mycobacterium tuberculosis
KW - Inflammation
KW - J 02350:Immunology
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Coincident+Helminth+Infection+Modulates+Systemic+Inflammation+and+Immune+Activation+in+Active+Pulmonary+Tuberculosis&rft.au=George%2C+Parakkal+Jovvian%3BKumar%2C+Nathella+Pavan%3BSridhar%2C+Rathinam%3BHanna%2C+Luke+E%3BNair%2C+Dina%3BBanurekha%2C+Vaithilingam+V%3BNutman%2C+Thomas+B%3BBabu%2C+Subash&rft.aulast=George&rft.aufirst=Parakkal&rft.date=2014-11-06&rft.volume=8&rft.issue=11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0003289
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Last updated - 2016-08-17
N1 - SubjectsTermNotLitGenreText - Lung; Immune system; Tuberculosis; Secondary infection; Immune response; Inflammation; Strongyloides stercoralis; Mycobacterium tuberculosis
DO - http://dx.doi.org/10.1371/journal.pntd.0003289
ER -
TY - JOUR
T1 - Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.
AN - 1622059203; 25186731
AB - The isolation of human monoclonal antibodies is providing important insights into the specificities that underlie broad neutralization of HIV-1 (reviewed in ref. 1). Here we report a broad and extremely potent HIV-specific monoclonal antibody, termed 35O22, which binds a novel HIV-1 envelope glycoprotein (Env) epitope. 35O22 neutralized 62% of 181 pseudoviruses with a half-maximum inhibitory concentration (IC50) <50 μg ml(-1). The median IC50 of neutralized viruses was 0.033 μg ml(-1), among the most potent thus far described. 35O22 did not bind monomeric forms of Env tested, but did bind the trimeric BG505 SOSIP.664. Mutagenesis and a reconstruction by negative-stain electron microscopy of the Fab in complex with trimer revealed that it bound to a conserved epitope, which stretched across gp120 and gp41. The specificity of 35O22 represents a novel site of vulnerability on HIV Env, which serum analysis indicates to be commonly elicited by natural infection. Binding to this new site of vulnerability may thus be an important complement to current monoclonal-antibody-based approaches to immunotherapies, prophylaxis and vaccine design.
JF - Nature
AU - Huang, Jinghe
AU - Kang, Byong H
AU - Pancera, Marie
AU - Lee, Jeong Hyun
AU - Tong, Tommy
AU - Feng, Yu
AU - Imamichi, Hiromi
AU - Georgiev, Ivelin S
AU - Chuang, Gwo-Yu
AU - Druz, Aliaksandr
AU - Doria-Rose, Nicole A
AU - Laub, Leo
AU - Sliepen, Kwinten
AU - van Gils, Marit J
AU - de la Peña, Alba Torrents
AU - Derking, Ronald
AU - Klasse, Per-Johan
AU - Migueles, Stephen A
AU - Bailer, Robert T
AU - Alam, Munir
AU - Pugach, Pavel
AU - Haynes, Barton F
AU - Wyatt, Richard T
AU - Sanders, Rogier W
AU - Binley, James M
AU - Ward, Andrew B
AU - Mascola, John R
AU - Kwong, Peter D
AU - Connors, Mark
AD - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. ; 1] The Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California 92037, USA [2] International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California 92037, USA. ; San Diego Biomedical Research Institute, San Diego, California 92121, USA. ; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California 92037, USA. ; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands. ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10065, USA. ; Duke Human Vaccine Institute, Duke University, Durham, North Carolina 27710, USA. ; 1] Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands [2] Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10065, USA.
Y1 - 2014/11/06/
PY - 2014
DA - 2014 Nov 06
SP - 138
EP - 142
VL - 515
IS - 7525
KW - AIDS Vaccines
KW - 0
KW - Antibodies, Monoclonal
KW - Antibodies, Neutralizing
KW - Antigens, CD4
KW - Epitopes
KW - HIV Antibodies
KW - HIV Envelope Protein gp120
KW - HIV Envelope Protein gp41
KW - Immunoglobulin Fab Fragments
KW - Receptors, CCR5
KW - Index Medicus
KW - HIV-1 -- immunology
KW - AIDS Vaccines -- chemistry
KW - Antibodies, Monoclonal -- genetics
KW - Humans
KW - Immunoglobulin Fab Fragments -- genetics
KW - Immunoglobulin Fab Fragments -- ultrastructure
KW - Antibodies, Monoclonal -- pharmacology
KW - Antigens, CD4 -- metabolism
KW - Antibodies, Monoclonal -- immunology
KW - Antibody Specificity
KW - Molecular Sequence Data
KW - Immunoglobulin Fab Fragments -- immunology
KW - Epitopes -- chemistry
KW - Inhibitory Concentration 50
KW - Immunoglobulin Fab Fragments -- chemistry
KW - Leukocytes, Mononuclear
KW - Cell Membrane -- virology
KW - AIDS Vaccines -- immunology
KW - Models, Molecular
KW - Antibodies, Monoclonal -- chemistry
KW - Conserved Sequence
KW - Epitopes -- immunology
KW - Epitope Mapping
KW - HIV-1 -- drug effects
KW - Receptors, CCR5 -- metabolism
KW - Cell Line
KW - Virus Internalization -- drug effects
KW - HIV Envelope Protein gp120 -- chemistry
KW - HIV Envelope Protein gp41 -- immunology
KW - HIV Antibodies -- genetics
KW - Antibody Affinity
KW - HIV Envelope Protein gp120 -- immunology
KW - HIV Antibodies -- immunology
KW - Antibodies, Neutralizing -- genetics
KW - Antibodies, Neutralizing -- chemistry
KW - Antibodies, Neutralizing -- immunology
KW - HIV Antibodies -- chemistry
KW - Antibodies, Neutralizing -- pharmacology
KW - HIV Antibodies -- pharmacology
KW - HIV Envelope Protein gp41 -- chemistry
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Broad+and+potent+HIV-1+neutralization+by+a+human+antibody+that+binds+the+gp41-gp120+interface.&rft.au=Huang%2C+Jinghe%3BKang%2C+Byong+H%3BPancera%2C+Marie%3BLee%2C+Jeong+Hyun%3BTong%2C+Tommy%3BFeng%2C+Yu%3BImamichi%2C+Hiromi%3BGeorgiev%2C+Ivelin+S%3BChuang%2C+Gwo-Yu%3BDruz%2C+Aliaksandr%3BDoria-Rose%2C+Nicole+A%3BLaub%2C+Leo%3BSliepen%2C+Kwinten%3Bvan+Gils%2C+Marit+J%3Bde+la+Pe%C3%B1a%2C+Alba+Torrents%3BDerking%2C+Ronald%3BKlasse%2C+Per-Johan%3BMigueles%2C+Stephen+A%3BBailer%2C+Robert+T%3BAlam%2C+Munir%3BPugach%2C+Pavel%3BHaynes%2C+Barton+F%3BWyatt%2C+Richard+T%3BSanders%2C+Rogier+W%3BBinley%2C+James+M%3BWard%2C+Andrew+B%3BMascola%2C+John+R%3BKwong%2C+Peter+D%3BConnors%2C+Mark&rft.aulast=Huang&rft.aufirst=Jinghe&rft.date=2014-11-06&rft.volume=515&rft.issue=7525&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=1476-4687&rft_id=info:doi/10.1038%2Fnature13601
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-12-22
N1 - Date created - 2014-11-06
N1 - Date revised - 2017-01-14
N1 - Genetic sequence - 4TOY; PDB; KM516890; GENBANK; KM516894; KM516893; KM516892; KM516891; KM516897; KM516896; KM516895; KM516888; KM516889; KM001887; KM001883; KM001884; KM001885; KM001886; KM001880; KM001881; KM001882; KM516887; KM516886; KM001878; KM001879; KM001876; KM001877; KM001874; KM001875; KM001872; KM001873
N1 - SuppNotes - Cited By:
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W375-83 [17452350]
Retrovirology. 2014;11:41 [24884783]
Nature. 2008 Sep 4;455(7209):109-13 [18668044]
J Virol. 2009 Jan;83(2):757-69 [18987148]
Nature. 2009 Apr 2;458(7238):636-40 [19287373]
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Nature. 2010 Sep 30;467(7315):591-5 [20882016]
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J Virol. 2011 Aug;85(16):8217-26 [21653673]
Science. 2011 Sep 16;333(6049):1633-7 [21764753]
Nature. 2011 Sep 22;477(7365):466-70 [21849977]
Nature. 2011 Dec 15;480(7377):336-43 [22113616]
J Virol. 2012 Apr;86(7):3574-87 [22301141]
J Virol. 2012 Apr;86(8):4688-92 [22301150]
PLoS One. 2012;7(9):e44241 [22970187]
Immunity. 2012 Sep 21;37(3):412-25 [22999947]
Nature. 2012 Nov 15;491(7424):406-12 [23151583]
Cell. 2013 Mar 28;153(1):126-38 [23540694]
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J Virol. 2013 Sep;87(18):10047-58 [23843642]
Nat Protoc. 2013 Oct;8(10):1907-15 [24030440]
PLoS Pathog. 2013 Sep;9(9):e1003618 [24068931]
J Clin Invest. 2013 Oct;123(10):4405-9 [23999429]
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18256-61 [24145402]
Science. 2013 Dec 20;342(6165):1477-83 [24179159]
Cell Rep. 2014 May 8;7(3):785-95 [24767986]
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Immunity. 2014 May 15;40(5):669-80 [24768348]
J Immunol Methods. 2008 Jan 1;329(1-2):112-24 [17996249]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1038/nature13601
ER -
TY - JOUR
T1 - The National Library of Medicine's (NLM) Hazardous Substances Data Bank (HSDB): background, recent enhancements and future plans.
AN - 1612286862; 25223694
AB - The National Library of Medicine's (NLM) Division of Specialized Information Services (SIS) Toxicology and Environmental Health Information Program is responsible for the management of the online Hazardous Substances Data Bank (HSDB). HSDB, a part of NLM's Toxicology Data Network (TOXNET(®)), is a file of chemical/substance information with one record for each specific chemical or substance, or for a category of chemicals or substances. Like the rest of TOXNET's databases and other resources, HSDB is available online at no cost to global users. HSDB has approximately 5600 chemicals and substances, with a focus on toxicology information and also on human exposure, industrial hygiene, emergency handling procedures, environmental fate, regulatory requirements, and related areas of likely interest to HSDB users. All data are from a core set of books, government documents, technical reports, selected primary journal literature, and other online sources of information, with a goal of linking the HSDB content to as much publicly available information as possible. HSDB's content is peer-reviewed by the Scientific Review Panel, a group of experts in the areas covering the scope of HSDB content. Recent enhancements include the addition of chemical structures to HSDB records, the addition of new subfields such as age groups for human data, more occupational exposure standards, and the addition of information on numerous nanomaterials. Examples of future plans include providing more exposure-related information, e.g., uses of a chemical or substance in consumer products; the addition of information summaries aimed towards consumers and other members of the public wanting to learn about a chemical or substance; more visual content such as diagrams (images) of the pathways of metabolism of a substance; and enhanced search features and navigation. Published by Elsevier Ireland Ltd.
JF - Toxicology
AU - Fonger, George Charles
AU - Hakkinen, Pertti
AU - Jordan, Shannon
AU - Publicker, Stephanie
AD - National Library of Medicine, Division of Specialized Information Services, Bethesda, MD 20894, USA. Electronic address: fongerg@mail.nlm.nih.gov. ; National Library of Medicine, Division of Specialized Information Services, Bethesda, MD 20894, USA.
Y1 - 2014/11/05/
PY - 2014
DA - 2014 Nov 05
SP - 209
EP - 216
VL - 325
KW - Hazardous Substances
KW - 0
KW - Index Medicus
KW - Information
KW - Databases
KW - Online
KW - National Library of Medicine
KW - United States
KW - Animals
KW - History, 21st Century
KW - History, 20th Century
KW - Access to Information
KW - Humans
KW - Information Dissemination
KW - Forecasting
KW - Internet
KW - Risk Assessment
KW - Databases, Factual -- trends
KW - Hazardous Substances -- classification
KW - Environmental Health -- trends
KW - National Library of Medicine (U.S.) -- trends
KW - Toxicology -- trends
KW - Toxicology -- history
KW - Environmental Health -- history
KW - Databases, Factual -- history
KW - National Library of Medicine (U.S.) -- history
KW - Hazardous Substances -- toxicity
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1612286862?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=The+National+Library+of+Medicine%27s+%28NLM%29+Hazardous+Substances+Data+Bank+%28HSDB%29%3A+background%2C+recent+enhancements+and+future+plans.&rft.au=Fonger%2C+George+Charles%3BHakkinen%2C+Pertti%3BJordan%2C+Shannon%3BPublicker%2C+Stephanie&rft.aulast=Fonger&rft.aufirst=George&rft.date=2014-11-05&rft.volume=325&rft.issue=&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2014.09.003
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-12-18
N1 - Date created - 2014-10-13
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.tox.2014.09.003
ER -
TY - JOUR
T1 - Estimation of the Probability of Exposure to Machining Fluids in a Population-Based Case-Control Study
AN - 1808729120; PQ0003494068
AB - We describe an approach for estimating the probability that study subjects were exposed to metalworking fluids (MWFs) in a population-based case-control study of bladder cancer. Study subject reports on the frequency of machining and use of specific MWFs (straight, soluble, and synthetic/semi-synthetic) were used to estimate exposure probability when available. Those reports also were used to develop estimates for job groups, which were then applied to jobs without MWF reports. Estimates using both cases and controls and controls only were developed. The prevalence of machining varied substantially across job groups (0.1->0.9%), with the greatest percentage of jobs that machined being reported by machinists and tool and die workers. Reports of straight and soluble MWF use were fairly consistent across job groups (generally 50-70%). Synthetic MWF use was lower (13-45%). There was little difference in reports by cases and controls vs. controls only. Approximately, 1% of the entire study population was assessed as definitely exposed to straight or soluble fluids in contrast to 0.2% definitely exposed to synthetic/semi-synthetics. A comparison between the reported use of the MWFs and U.S. production levels found high correlations (r generally >0.7). Overall, the method described here is likely to have provided a systematic and reliable ranking that better reflects the variability of exposure to three types of MWFs than approaches applied in the past. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resources: a list of keywords in the occupational histories that were used to link study subjects to the metalworking fluids (MWFs) modules; recommendations from the literature on selection of MWFs based on type of machining operation, the metal being machined and decade; popular additives to MWFs; the number and proportion of controls who reported various MWF responses by job group; the number and proportion of controls assigned to the MWF types by job group and exposure category; and the distribution of cases and controls assigned various levels of probability by MWF type.]
JF - Journal of Occupational and Environmental Hygiene
AU - Park, Dong-Uk
AU - Colt, Joanne S
AU - Baris, Dalsu
AU - Schwenn, Molly
AU - Karagas, Margaret R
AU - Armenti, Karla R
AU - Johnson, Alison
AU - Silverman, Debra T
AU - Stewart, Patricia A
AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Y1 - 2014/11/02/
PY - 2014
DA - 2014 Nov 02
SP - 757
EP - 770
PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom
VL - 11
IS - 11
SN - 1545-9624, 1545-9624
KW - Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts
KW - Historical account
KW - Metals
KW - Urinary bladder
KW - Population studies
KW - Metal-working fluids
KW - Cancer
KW - Workers
KW - Hygiene
KW - Additives
KW - Internet
KW - Occupational exposure
KW - Environmental hygiene
KW - H 1000:Occupational Safety and Health
KW - X 24360:Metals
KW - ENA 02:Toxicology & Environmental Safety
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808729120?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Estimation+of+the+Probability+of+Exposure+to+Machining+Fluids+in+a+Population-Based+Case-Control+Study&rft.au=Park%2C+Dong-Uk%3BColt%2C+Joanne+S%3BBaris%2C+Dalsu%3BSchwenn%2C+Molly%3BKaragas%2C+Margaret+R%3BArmenti%2C+Karla+R%3BJohnson%2C+Alison%3BSilverman%2C+Debra+T%3BStewart%2C+Patricia+A&rft.aulast=Park&rft.aufirst=Dong-Uk&rft.date=2014-11-02&rft.volume=11&rft.issue=11&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2014.918984
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-07-01
N1 - Last updated - 2016-09-01
N1 - SubjectsTermNotLitGenreText - Workers; Metals; Urinary bladder; Population studies; Cancer; Occupational exposure; Internet; Environmental hygiene; Historical account; Hygiene; Additives; Metal-working fluids
DO - http://dx.doi.org/10.1080/15459624.2014.918984
ER -
TY - JOUR
T1 - Spoiling and Sustainability: Technology, Water Insecurity, and Visibility in Arctic Alaska
AN - 1622612928; 20825382
AB - One third of households in Alaska Native villages lack running water and sewer services. Historically, this public health need drove policies to improve access to treated water and sanitation. However, despite public health being a stated priority of water infrastructure development, current policies require demonstrated economic sustainability in ways that render suffering from water insecurity invisible. In this article, I situate the introduction of water treatment technologies within the history of domination coproduced with vulnerability. These processes are reflected in local narratives describing the relationships between technology, tradition, and suffering. By drawing attention to the role of the state in creating vulnerability, village leaders are trying to historicize and insert their health concerns into the sustainability conversation using narratives that both fit within and challenge the ideology of sustainability. These narratives are thus central to Inupiat struggles for visibility.
JF - Medical Anthropology
AU - Eichelberger, Laura
AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland, USA
Y1 - 2014/11/02/
PY - 2014
DA - 2014 Nov 02
SP - 478
EP - 496
PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom
VL - 33
IS - 6
SN - 0145-9740, 0145-9740
KW - Health & Safety Science Abstracts; Sustainability Science Abstracts
KW - USA, Alaska
KW - Historical account
KW - Anthropology
KW - Polar environments
KW - Traditions
KW - Sustainability
KW - Public health
KW - PN, Arctic
KW - Sanitation
KW - Water treatment
KW - Villages
KW - Households
KW - Economics
KW - Visibility
KW - Vulnerability
KW - Technology
KW - M3 1010:Issues in Sustainable Development
KW - H 12000:Epidemiology and Public Health
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622612928?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Anthropology&rft.atitle=Spoiling+and+Sustainability%3A+Technology%2C+Water+Insecurity%2C+and+Visibility+in+Arctic+Alaska&rft.au=Eichelberger%2C+Laura&rft.aulast=Eichelberger&rft.aufirst=Laura&rft.date=2014-11-02&rft.volume=33&rft.issue=6&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Medical+Anthropology&rft.issn=01459740&rft_id=info:doi/10.1080%2F01459740.2014.917374
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-01
N1 - Last updated - 2014-11-26
N1 - SubjectsTermNotLitGenreText - Historical account; Anthropology; Traditions; Polar environments; Sustainability; Public health; Sanitation; Villages; Water treatment; Households; Economics; Visibility; Vulnerability; Technology; USA, Alaska; PN, Arctic
DO - http://dx.doi.org/10.1080/01459740.2014.917374
ER -
TY - JOUR
T1 - Is CD4 Monitoring Needed Among Ugandan Clients Achieving a Virologic and Immunologic Response to Treatment?
AN - 1827882746; PQ0003681045
AB - It is unclear whether ongoing CD4 monitoring is needed following immunologic and virologic response to antiretroviral therapy (ART). We investigated the proportion of clients who achieved a virologic and immunologic response and then had a subsequent CD4 count <200 cells/ mu L despite continued virologic suppression. Included in this analysis were clients receiving ART through the Rakai Health Sciences Program between June 2004-May 2013 who achieved a CD4 greater than or equal to 200 cells/ mu L and VL less than or equal to 400 copies/mL and who had three sets of CD4 and VL measurements (defined as a sequence) within a 390 day period. A CD4 decline was defined as any drop in CD4 count to <200 cells/ mu L during a period of viral suppression. A total of 1553 clients were included, 68% females, mean age of 35.5 years (SD 8.3), median baseline CD4 count 183 cells/ mu L (IQR 106-224). 43 (2.8%) clients developed CD4 declines, the majority, 32/43 (74%), among individuals whose initial CD4 was <300 cells/ mu L. Of the 43 clients with CD4 declines, 24 had an additional CD4 measurement and 20/24 (83%) achieved a CD4 greater than or equal to 200 cell/ mu L on their next measurement (median 285 cells/ mu L; IQR 220-365). CD4 declines were significantly greater among those with lower CD4 at sequence initiation [adjusted hazard ratio (AHR) 4.3 (95% CI 2.1, 9.0) CD4 200-249 versus greater than or equal to 350 cells/ mu L]. Clients who achieved an immunologic and virologic response to ART were unlikely to experience a subsequent CD4 count decline to <200 cells/ mu L, and among those experiencing a decline, the majority were transient in nature. Thus, ongoing CD4 monitoring could be omitted.
JF - AIDS Patient Care and STDs
AU - Reynolds, Steven J
AU - Sempa, Joseph B
AU - Kiragga, Agnes N
AU - Newell, Kevin
AU - Nakigozi, Gertrude
AU - Galiwango, Ronald
AU - Gray, Ron
AU - Quinn, Thomas C
AU - Serwadda, David
AU - Chang, Larry
AD - Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 575
EP - 578
PB - Mary Ann Liebert, Inc., 2 Madison Ave Larchmont NY 10538 United States
VL - 28
IS - 11
SN - 1087-2914, 1087-2914
KW - Immunology Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts
KW - Acquired immune deficiency syndrome
KW - CD4 antigen
KW - Age
KW - antiretroviral therapy
KW - Antiretroviral agents
KW - Sexually transmitted diseases
KW - V 22360:AIDS and HIV
KW - H 11000:Diseases/Injuries/Trauma
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827882746?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Patient+Care+and+STDs&rft.atitle=Is+CD4+Monitoring+Needed+Among+Ugandan+Clients+Achieving+a+Virologic+and+Immunologic+Response+to+Treatment%3F&rft.au=Reynolds%2C+Steven+J%3BSempa%2C+Joseph+B%3BKiragga%2C+Agnes+N%3BNewell%2C+Kevin%3BNakigozi%2C+Gertrude%3BGaliwango%2C+Ronald%3BGray%2C+Ron%3BQuinn%2C+Thomas+C%3BSerwadda%2C+David%3BChang%2C+Larry&rft.aulast=Reynolds&rft.aufirst=Steven&rft.date=2014-11-01&rft.volume=28&rft.issue=11&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=AIDS+Patient+Care+and+STDs&rft.issn=10872914&rft_id=info:doi/10.1089%2Fapc.2014.0086
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-10-01
N1 - Number of references - 17
N1 - Last updated - 2016-10-26
N1 - SubjectsTermNotLitGenreText - Age; CD4 antigen; antiretroviral therapy; Acquired immune deficiency syndrome; Antiretroviral agents; Sexually transmitted diseases
DO - http://dx.doi.org/10.1089/apc.2014.0086
ER -
TY - JOUR
T1 - Predictive prognostic role of miR-181a with discrepancy in the liver and serum of genotype 4 hepatitis C virus patients.
AN - 1826615268; 25279157
AB - microRNA (miRNA) expression in organs does not always represent their quantity in serum. A disparity in the expression of miR-181a has been reported in the tissues and serum of hepatocellular carcinoma (HCC) patients. Since hepatitis C virus (HCV) is a major cause of HCC and miR-181a has never been studied in HCV, the present study aimed to investigate the miR-181a expression profile in genotype 4 (GT4)-HCV patients to evaluate whether this pattern is also apparent in HCV. RNA was extracted from liver tissues, peripheral mononuclear cells (PBMCs) and serum samples from GT4-HCV-infected patients and healthy donors to evaluate the relative miR-181a expression using quantitative reverse transcription-polymerase chain reaction. miR-181a was significantly higher in the serum of naïve patients compared to controls, and an inverse correlation with the viral load and liver enzymes was apparent. By contrast, no difference in miR-181a expression was observed in the liver tissues and PBMCs of patients compared to controls. This expression observed in HCV is conflicting to that previously reported in HCC. The study also demonstrates a significant upregulation of miR-181a post-interferon/ribavirin treatment in the serum of sustained virological responders (SVRs) compared to non-responders and treatment-naïve SVRs. In conclusion, miR-181a may be considered to be a possible prognostic marker in GT4-HCV infection.
JF - Biomedical reports
AU - Elhelw, Dalia Sherif
AU - Mekky, Radwa Yehia
AU - El-Ekiaby, Nada
AU - Ahmed, Rasha
AU - Eldin, Mohammad Ahmed Mohey
AU - El-Sayed, Mohammad
AU - Abouelkhair, Mahmoud Mohammad
AU - Salah, Ayman
AU - Zekri, Abdel Rahman
AU - Esmat, Gamal
AU - Abdelaziz, Ahmed Ihab
AD - The Molecular Pathology Research Group, Department of Pharmacology and Toxicology, German University in Cairo, New Cairo 11835, Egypt. ; Department of Endemic Medicine and Hepatology, Cairo University, Cairo 11562, Egypt. ; Department of Surgery, Cairo University, Cairo 11562, Egypt. ; Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11976, Egypt.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 843
EP - 848
VL - 2
IS - 6
SN - 2049-9434, 2049-9434
KW - genotype 4
KW - treatment response
KW - microRNA-181a
KW - hepatitis C virus
KW - sustained virological responders
KW - prognosis
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826615268?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+reports&rft.atitle=Predictive+prognostic+role+of+miR-181a+with+discrepancy+in+the+liver+and+serum+of+genotype+4+hepatitis+C+virus+patients.&rft.au=Elhelw%2C+Dalia+Sherif%3BMekky%2C+Radwa+Yehia%3BEl-Ekiaby%2C+Nada%3BAhmed%2C+Rasha%3BEldin%2C+Mohammad+Ahmed+Mohey%3BEl-Sayed%2C+Mohammad%3BAbouelkhair%2C+Mahmoud+Mohammad%3BSalah%2C+Ayman%3BZekri%2C+Abdel+Rahman%3BEsmat%2C+Gamal%3BAbdelaziz%2C+Ahmed+Ihab&rft.aulast=Elhelw&rft.aufirst=Dalia&rft.date=2014-11-01&rft.volume=2&rft.issue=6&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Biomedical+reports&rft.issn=20499434&rft_id=info:doi/
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date created - 2014-10-03
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
ER -
TY - JOUR
T1 - Inhibition of NANOG/NANOGP8 Downregulates MCL-1 in Colorectal Cancer Cells and Enhances the Therapeutic Efficacy of BH3 Mimetics
AN - 1808625193; PQ0003452462
AB - Purpose: High levels of BCL-2 family members in colorectal carcinoma cause resistance to treatment. Inhibition of NANOG or its paralog NANOGP8 reduces the proliferation, stemness, and tumorigenicity of colorectal carcinoma cells. Our hypothesis was that inhibition of NANOG/NANOGP8 enhances the cytotoxic effect of BH3 mimetics targeting BCL-2 family members in colorectal carcinoma cells through reducing expression of MCL-1, a prosurvival BCL-2 protein.Experimental Design: Lentiviral vector (LV) shRNA to NANOG (shNG-1) or NANOGP8 (shNp8-1) transduced colorectal carcinoma cells that were also exposed to the BH3 mimetics ABT-737 or ABT-199 in vivo in colorectal carcinoma xenografts and in vitro where proliferation, protein and gene expression, and apoptosis were measured.Results: Clone A and CX-1 were sensitive to ABT-737 and ABT-199 at IC50s of 2 to 9 mu mol/L but LS174T was resistant with IC50s of 18 to 30 mu mol/L. Resistance was associated with high MCL-1 expression in LS174T. LVshNG-1 or LVshNp8-1 decreased MCL-1 expression, increased apoptosis, and decreased replating efficiency in colorectal carcinoma cells treated with either ABT-737 or ABT-199 compared with the effects of either BH3 mimetic alone. Inhibition or overexpression of MCL-1 alone replicated the effects of LVshNG-1 or LVshNp8-1 in increasing or decreasing the apoptosis caused with the BH3 mimetic. The combination therapy inhibited the growth of LS174T xenografts in vivo compared with untreated controls or treatment with only LV shRNA or ABT-737.Conclusions: Inhibition of NANOGP8 or NANOG enhances the cytotoxicity of BH3 mimetics that target BCL-2 family members. Gene therapy targeting the NANOGs may increase the efficacy of BH3 mimetics in colorectal carcinoma. Clin Cancer Res; 20(21); 5446-55. copyright 2014 AACR.
JF - Clinical Cancer Research
AU - Mattoo, Abid R
AU - Zhang, Jingyu
AU - Espinoza, Luis A
AU - Jessup, JMilburn
AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, jessupj@mail.nih.gov
Y1 - 2014/11/01/
PY - 2014
DA - 2014 Nov 01
SP - 5446
EP - 5455
PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States
VL - 20
IS - 21
SN - 1078-0432, 1078-0432
KW - Biotechnology and Bioengineering Abstracts
KW - Expression vectors
KW - Cytotoxicity
KW - Apoptosis
KW - Gene therapy
KW - Mcl-1 protein
KW - Colorectal cancer
KW - Colorectal carcinoma
KW - Tumorigenicity
KW - Bcl-2 protein
KW - Xenografts
KW - Cell proliferation
KW - W 30905:Medical Applications
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808625193?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Inhibition+of+NANOG%2FNANOGP8+Downregulates+MCL-1+in+Colorectal+Cancer+Cells+and+Enhances+the+Therapeutic+Efficacy+of+BH3+Mimetics&rft.au=Mattoo%2C+Abid+R%3BZhang%2C+Jingyu%3BEspinoza%2C+Luis+A%3BJessup%2C+JMilburn&rft.aulast=Mattoo&rft.aufirst=Abid&rft.date=2014-11-01&rft.volume=20&rft.issue=21&rft.spage=5446&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-1134
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-07-01
N1 - Last updated - 2016-08-17
N1 - SubjectsTermNotLitGenreText - Expression vectors; Cytotoxicity; Apoptosis; Gene therapy; Mcl-1 protein; Colorectal cancer; Tumorigenicity; Colorectal carcinoma; Xenografts; Bcl-2 protein; Cell proliferation
DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-1134
ER -
TY - JOUR
T1 - HIV-1 Envelope Glycoprotein Trimer Immunogenicity Elicited in the Presence of Human CD4 Alters the Neutralization Profile
AN - 1768582376; PQ0002687106
AB - The HIV-1 envelope glycoproteins (Env) gp120 and gp41 are the sole virally derived components on the surface of the virus. These glycoproteins mediate receptor binding and entry and are targets for neutralizing antibodies. The most highly validated protein region on Env that is a target for broadly neutralizing antibodies is the conserved CD4 binding site. Mimetics of Env have been used in attempts to elicit antibodies to the CD4 binding site. Some trimers, such as the soluble foldon trimers used here, elicit 5-10% of the Env-directed B cell response to this conserved region. As these trimers, or other Env versions, advance into clinical development, there is both considerable interest and concern as to whether binding to the abundant CD4 present on the surface of T cells and macrophages may blunt potentially protective antibody responses to this site. Here, we utilized rabbits transgenic for human CD4 to evaluate the role of CD4:Env interaction in vivo relative to the elicitation of Env-directed antibodies following immunization. We analyzed responses to trimers both capable and incapable of recognizing human CD4 with high affinity. We demonstrated that the presence of human CD4 in vivo did not significantly affect the overall elicitation of Env binding or CD4bs-directed antibodies. However, the presence of CD4 did reduce the capacity of elicited serum antibodies to neutralize the clade C isolate, MW965. Reduction of HXBc2 neutralization was associated with the CD4 binding-incompetent trimers. These results highlight an important consideration regarding CD4 binding-competent trimeric Env immunogens as they enter the clinic for human vaccine trials.
JF - AIDS Research and Human Retroviruses
AU - Forsell, Mattias NE
AU - McKee, Krisha
AU - Feng, Yu
AU - Mascola, John R
AU - Wyatt, Richard T
AD - Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 1089
EP - 1098
PB - Mary Ann Liebert, Inc., 140 Huguenot Street New Rochelle NY 10801 United States
VL - 30
IS - 11
SN - 0889-2229, 0889-2229
KW - Immunology Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts
KW - Macrophages
KW - Acquired immune deficiency syndrome
KW - glycoprotein gp41
KW - Lymphocytes B
KW - Clinical trials
KW - Immunization
KW - Glycoprotein gp120
KW - CD4 antigen
KW - Antibodies
KW - Retrovirus
KW - Envelopes
KW - Immunogenicity
KW - Human immunodeficiency virus 1
KW - Lymphocytes T
KW - Proteins
KW - Glycoproteins
KW - Vaccines
KW - Neutralization
KW - H 6000:Natural Disasters/Civil Defense/Emergency Management
KW - V 22360:AIDS and HIV
KW - F 06910:Microorganisms & Parasites
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768582376?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Research+and+Human+Retroviruses&rft.atitle=HIV-1+Envelope+Glycoprotein+Trimer+Immunogenicity+Elicited+in+the+Presence+of+Human+CD4+Alters+the+Neutralization+Profile&rft.au=Forsell%2C+Mattias+NE%3BMcKee%2C+Krisha%3BFeng%2C+Yu%3BMascola%2C+John+R%3BWyatt%2C+Richard+T&rft.aulast=Forsell&rft.aufirst=Mattias&rft.date=2014-11-01&rft.volume=30&rft.issue=11&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=AIDS+Research+and+Human+Retroviruses&rft.issn=08892229&rft_id=info:doi/10.1089%2Faid.2014.0104
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-02-01
N1 - Number of references - 34
N1 - Last updated - 2016-03-17
N1 - SubjectsTermNotLitGenreText - Macrophages; Glycoprotein gp120; Antibodies; CD4 antigen; Envelopes; glycoprotein gp41; Lymphocytes B; Immunogenicity; Lymphocytes T; Vaccines; Clinical trials; Immunization; Acquired immune deficiency syndrome; Proteins; Glycoproteins; Neutralization; Retrovirus; Human immunodeficiency virus 1
DO - http://dx.doi.org/10.1089/aid.2014.0104
ER -
TY - JOUR
T1 - Do newspaper reports of suicides comply with standard suicide reporting guidelines? A study from Bangalore, India
AN - 1695153284
AB - Background: Several countries have prescribed standard guidelines for media professionals on suicide reporting. However, the implementation of these guidelines has been varied. Suicide rates in South Asia are one of the highest in the world, and it is known that media guidelines for suicide reporting are not followed adequately. However, there are no published reports available from this region. Aim: This study aimed at assessing newspaper reports of suicide for quality of reporting based on standard reporting guidelines and to study differences between English and vernacular (Kannada) newspapers in Bangalore, South India. Methods: A total of 341 newspaper reports of suicide from 550 newspapers (3 English and 3 Kannada) over 3 months were systematically assessed for compliance with reporting guidelines. Each report was evaluated on 2 domains and 36 parameters. Data were analyzed for frequency of inappropriate reporting and patterns compared between vernacular and English newspapers. Results: In all, 87% of the reports were those of completed suicide. Non-compliant reporting – method of suicide was reported in 89% and 32% of reports were in prominent pages of the newspaper, 95% mentioned gender, 90% reported the name, 80% reported age and suicide location, 75% reported life events related to suicide, 70% reported occupation, 69% had headline explicity on suicide and 61% reported monocausality. Only 16% reported mental disorder related to suicide, and less than 3% included information on suicide prevention and helplines. Vernacular papers showed significantly better compliance in 16 of the 20 areas. However, protective characteristics were better reported in English newspapers. Conclusion: Majority of reports on suicides in newspapers from Bangalore did not comply with standard guidelines of reporting. There is a strong need to evolve local guidelines and mechanisms for ensuring responsible reporting which have important implications in prevention of suicide.
JF - The International Journal of Social Psychiatry
AU - Chandra, Prabha S
AU - Doraiswamy, Padmavathy
AU - Padmanabh, Anuroopa
AU - Philip, Mariamma
AD - NIMHANS Centre for Well-Being, National Institute of Mental Health and Neurosciences, Bangalore, India ; NIMHANS Centre for Well-Being, Department of Nursing, National Institute of Mental Health and Neurosciences, Bangalore, India ; Department of Biostatistics, National Institute of Mental Health and Neurosciences, Bangalore, India ; NIMHANS Centre for Well-Being, National Institute of Mental Health and Neurosciences, Bangalore, India
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 687
EP - 694
CY - London
PB - SAGE PUBLICATIONS, INC.
VL - 60
IS - 7
SN - 0020-7640
KW - Medical Sciences--Psychiatry And Neurology
KW - Suicide
KW - media
KW - suicide reporting
KW - India
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1695153284?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+Journal+of+Social+Psychiatry&rft.atitle=Do+newspaper+reports+of+suicides+comply+with+standard+suicide+reporting+guidelines%3F+A+study+from+Bangalore%2C+India&rft.au=Chandra%2C+Prabha+S%3BDoraiswamy%2C+Padmavathy%3BPadmanabh%2C+Anuroopa%3BPhilip%2C+Mariamma&rft.aulast=Chandra&rft.aufirst=Prabha&rft.date=2014-11-01&rft.volume=60&rft.issue=7&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=The+International+Journal+of+Social+Psychiatry&rft.issn=00207640&rft_id=info:doi/10.1177%2F0020764013513438
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-06-18
N1 - Last updated - 2016-09-08
N1 - SubjectsTermNotLitGenreText - India
DO - http://dx.doi.org/10.1177/0020764013513438
ER -
TY - JOUR
T1 - Concerns about unintended negative consequences of informing the public about multifactorial risks may be premature for young adult smokers
AN - 1665160477
AB - Background Many health risks are associated with both genetic and behavioural factors. Concerns have been raised that learning about such multifactorial risks might have detrimental effects on health-related beliefs, cognitions, and affect. However, experimental evidence is sparse. Objective To explore the effects of reading an online news article about the discovery of a genetic basis for nicotine addiction. Methods Smokers ( N = 333) were recruited from the psychology subject pools of two major universities. Participants were randomly assigned to read one of three news articles: one describing a genetic basis for nicotine addiction and lung cancer obtained from a national news source, one altered to indicate no genetic basis for nicotine addiction and lung cancer, or one unrelated attention control. Participants then completed an online questionnaire, which assessed smoking-related cognitions and affect, and beliefs about nicotine addiction, quitting smoking, and whether the harms of tobacco use are delayed. Results There was no statistically significant influence of experimental condition on smoking-related cognitions/affect ( ps > .05, η2 < .002), beliefs about addiction and quitting (Wilksʼ λ = .98, p = .66, η2 = .01), or delayed harm ( ps > .05, η2 < .002). Conclusion Reading an online news article about the presence or absence of a genetic basis for nicotine addiction was not found to change smoking-related cognitions/affect or beliefs among young adult smokers. Concerns about negative effects of multifactorial risk information on health beliefs may be premature. Nevertheless, to effectively translate basic genomics research into effective public health practice, further research should investigate these issues in different populations, via different communication modalities, and for different health outcomes. Statement of contribution What is already known on this subject? * Information about the health implications of the interaction between genetics and behaviour is becoming prevalent. * Learning about these interactions may reduce perceived risk and intentions to engage in health behaviours. What does this study add?* Informing young adult smokers about the genetic basis for nicotine addiction does not affect health beliefs negatively. * Responses are not moderated by endorsing the idea of genetic causation or current/experimenter smoking status.
JF - British Journal of Health Psychology
AU - Waters, Erika A
AU - Kincaid, Caroline
AU - Kaufman, Annette R
AU - Stock, Michelle L
AU - Peterson, Laurel M
AU - Muscanell, Nicole L
AU - Guadagno, Rosanna E
AD - Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA. ; Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland, USA. ; Department of Psychology, George Washington University, Washington, District of Columbia, USA. ; Department of Psychiatry, University of Pittsburgh, Pennsylvania, USA. ; Department of Psychology, The University of Alabama, Tuscaloosa, Alabama, USA. ; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA.
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 720
EP - 736
CY - Leicester
PB - British Psychological Society
VL - 19
IS - 4
SN - 1359-107X
KW - Psychology
KW - Addiction
KW - Adults
KW - Articles
KW - Causality
KW - Health behaviour
KW - Health status
KW - Internet
KW - Learning
KW - Lung cancer
KW - Medical research
KW - Moderated
KW - Negative events
KW - News
KW - Nicotine
KW - Premature
KW - Public health
KW - Basis
KW - Behaviour
KW - Beliefs
KW - Cancer
KW - Cessation
KW - Cognition
KW - Communication
KW - Consequences
KW - Delayed
KW - Discovery
KW - Genetic factors
KW - Health
KW - Health beliefs
KW - Health risks
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Health+Psychology&rft.atitle=Concerns+about+unintended+negative+consequences+of+informing+the+public+about+multifactorial+risks+may+be+premature+for+young+adult+smokers&rft.au=Waters%2C+Erika+A%3BKincaid%2C+Caroline%3BKaufman%2C+Annette+R%3BStock%2C+Michelle+L%3BPeterson%2C+Laurel+M%3BMuscanell%2C+Nicole+L%3BGuadagno%2C+Rosanna+E&rft.aulast=Waters&rft.aufirst=Erika&rft.date=2014-11-01&rft.volume=19&rft.issue=4&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Health+Psychology&rft.issn=1359107X&rft_id=info:doi/10.1111%2Fbjhp.12069
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-01-09
N1 - Last updated - 2016-05-24
DO - http://dx.doi.org/10.1111/bjhp.12069
ER -
TY - JOUR
T1 - Symptoms of Attention-Deficit/Hyperactivity Disorder and Peer Functioning: a Transactional Model of Development
AN - 1665155814
AB - The goals of this short-term longitudinal study were to investigate differential, independent effects of inattention and hyperactivity/impulsivity on children’s peer relationships and the dynamic, transactional interplay between ADHD symptoms and indices of peer functioning over time. This study used a community sample that included 739 preadolescents (239 fourth graders and 500 fifth graders; 52.23 % boys) from northern Taiwan, who were assessed every six months at three time points. Children’s ADHD symptoms were measured using the parent report on the Swanson, Nolan, and Pelham, version IV scale. Positive and negative facets of peer functioning, including peer rejection, peer acceptance, and the number of friendships, were assessed via peer nomination. Results of cross-lagged models indicated that inattention, but not hyperactivity/impulsivity, predicted subsequent peer impairment (i.e., lower peer acceptance and fewer dyadic friendships). Findings also showed a vicious cycle in which inattentive symptoms predicted later peer impairment, which in turn led to increases in both inattention and hyperactivity/impulsivity. These findings did not differ across gender, and the majority of the findings remained significant even after controlling for age and physical aggression. Taken together, this study demonstrated the detrimental effect of inattention on children’s peer functioning and the transactional and dynamic interplay between inattention and peer impairment in a Chinese culture.
JF - Journal of Abnormal Child Psychology
AU - Tseng, Wan-Ling
AU - Kawabata, Yoshito
AU - Gau, Susan Shur-Fen
AU - Crick, Nicki R
AD - Institute of Child Development, University of Minnesota, Minneapolis, USA wan-ling.tseng@nih.gov wan-ling.tseng@nih.gov wan-ling.tseng@nih.gov; Department of Psychiatry, National Taiwan University Hospital and College of Medicine, 7 Chung-Shan Road, Taipei, 10002, Taiwan gaushufe@ntu.edu.tw; Institute of Child Development, University of Minnesota, Minneapolis, USA
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 1353
EP - 1365
CY - New York
PB - Springer Science & Business Media
VL - 42
IS - 8
SN - 0091-0627
KW - Medical Sciences--Physical Medicine And Rehabilitation
KW - Acceptance
KW - Aggressive young boys
KW - Aggression
KW - Attention deficit hyperactivity disorder
KW - Attention deficits
KW - Boys
KW - Children
KW - Friendships
KW - Gender
KW - Hyperactivity
KW - Impulsivity
KW - Peer acceptance
KW - Peer rejection
KW - Peer relationships
KW - Rejection
KW - Short term
KW - Taiwan
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665155814?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Child+Psychology&rft.atitle=Symptoms+of+Attention-Deficit%2FHyperactivity+Disorder+and+Peer+Functioning%3A+a+Transactional+Model+of+Development&rft.au=Tseng%2C+Wan-Ling%3BKawabata%2C+Yoshito%3BGau%2C+Susan+Shur-Fen%3BCrick%2C+Nicki+R&rft.aulast=Tseng&rft.aufirst=Wan-Ling&rft.date=2014-11-01&rft.volume=42&rft.issue=8&rft.spage=1353&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Child+Psychology&rft.issn=00910627&rft_id=info:doi/10.1007%2Fs10802-014-9883-8
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-01-09
N1 - Last updated - 2016-05-12
N1 - SubjectsTermNotLitGenreText - Taiwan
DO - http://dx.doi.org/10.1007/s10802-014-9883-8
ER -
TY - JOUR
T1 - Exploring psychological responses to genetic testing for Lynch Syndrome within the family context
AN - 1665154316
AB - Objective Genetic testing for hereditary cancer susceptibility syndromes is a family-centered process. Nonetheless, little research has explored how the family context affects psychological responses to genetic testing. We examine how personal test results and the test results of immediate and extended family members shape responses to genetic testing. Methods Individuals at risk of carrying a mutation associated with an inherited cancer susceptibility syndrome (Lynch syndrome) received genetic testing. Six months after receiving their results, participants reported on cancer distress, cancer worry, and depressive symptoms. Results Among mutation carriers for Lynch syndrome, the higher the proportion of carriers in their immediate family, the less cancer worry and distress they reported. In contrast, mutation carriers and non-carriers with a high proportion of carriers in their immediate family and mutation carriers with a high proportion of carriers in their extended family were at elevated risk for clinically significant levels of depressive symptoms. Conclusion Personal test results alone are not highly predictive of psychological outcomes. Instead, the interaction between personal and family test results, or in some cases, family test results alone, predict key psychological outcomes. The current research has important implications for genetic counseling and intervention efforts. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
JF - Psycho-Oncology
AU - Eliezer, Dina
AU - Hadley, Donald W
AU - Koehly, Laura M
AD - National Human Genome Research Institute, Bethesda, MD, USA. ; National Human Genome Research Institute, Bethesda, MD, USA.
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 1292
EP - 1299
CY - Chichester
PB - Wiley Subscription Services, Inc.
VL - 23
IS - 11
SN - 1057-9249
KW - Medical Sciences--Psychiatry And Neurology
KW - At risk
KW - Cancer
KW - Carriers
KW - Counselling
KW - Depression
KW - Genetic counselling
KW - Genetic screening
KW - Psychological distress
KW - Public domain
KW - Relatives
KW - Susceptibility
KW - Symptoms
KW - United States--US
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665154316?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Exploring+psychological+responses+to+genetic+testing+for+Lynch+Syndrome+within+the+family+context&rft.au=Eliezer%2C+Dina%3BHadley%2C+Donald+W%3BKoehly%2C+Laura+M&rft.aulast=Eliezer&rft.aufirst=Dina&rft.date=2014-11-01&rft.volume=23&rft.issue=11&rft.spage=1292&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.3551
LA - English
DB - Applied Social Sciences Index & Abstracts (ASSIA)
N1 - Date revised - 2015-01-09
N1 - Last updated - 2016-05-13
N1 - SubjectsTermNotLitGenreText - United States--US
DO - http://dx.doi.org/10.1002/pon.3551
ER -
TY - JOUR
T1 - Reliability and validity of expert assessment based on airborne and urinary measures of nickel and chromium exposure in the electroplating industry
AN - 1664212763; PQ0001187959
AB - The reliability and validity of six experts' exposure ratings were evaluated for 64 nickel-exposed and 72 chromium-exposed workers from six Shanghai electroplating plants based on airborne and urinary nickel and chromium measurements. Three industrial hygienists and three occupational physicians independently ranked the exposure intensity of each metal on an ordinal scale (1-4) for each worker's job in two rounds: the first round was based on responses to an occupational history questionnaire and the second round also included responses to an electroplating industry-specific questionnaire. The Spearman correlation (r sub(s)) was used to compare each rating's validity to its corresponding subject-specific arithmetic mean of four airborne or four urinary measurements. Reliability was moderately high (weighted kappa range=0.60-0.64). Validity was poor to moderate (r sub(s)=-0.37-0.46) for both airborne and urinary concentrations of both metals. For airborne nickel concentrations, validity differed by plant. For dichotomized metrics, sensitivity and specificity were higher based on urinary measurements (47-78%) than airborne measurements (16-50%). Few patterns were observed by metal, assessment round, or expert type. These results suggest that, for electroplating exposures, experts can achieve moderately high agreement and (reasonably) distinguish between low and high exposures when reviewing responses to in-depth questionnaires used in population-based case-control studies.
JF - Journal of Exposure Science and Environmental Epidemiology
AU - Chen, Yu-Cheng
AU - Coble, Joseph B
AU - Deziel, Nicole C
AU - Ji, Bu-Tian
AU - Xue, Shouzheng
AU - Lu, Wei
AU - Stewart, Patricia A
AU - Friesen, Melissa C
AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 622
EP - 628
PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom
VL - 24
IS - 6
SN - 1559-0631, 1559-0631
KW - Toxicology Abstracts; Health & Safety Science Abstracts; Environment Abstracts
KW - Metals
KW - Historical account
KW - Sensitivity
KW - Inventories
KW - Chromium
KW - Heavy metals
KW - Nickel
KW - Mathematics
KW - Urine
KW - Metal finishing industry
KW - China, People's Rep., Shanghai
KW - Occupational exposure
KW - H 1000:Occupational Safety and Health
KW - X 24360:Metals
KW - ENA 02:Toxicology & Environmental Safety
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664212763?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Reliability+and+validity+of+expert+assessment+based+on+airborne+and+urinary+measures+of+nickel+and+chromium+exposure+in+the+electroplating+industry&rft.au=Chen%2C+Yu-Cheng%3BCoble%2C+Joseph+B%3BDeziel%2C+Nicole+C%3BJi%2C+Bu-Tian%3BXue%2C+Shouzheng%3BLu%2C+Wei%3BStewart%2C+Patricia+A%3BFriesen%2C+Melissa+C&rft.aulast=Chen&rft.aufirst=Yu-Cheng&rft.date=2014-11-01&rft.volume=24&rft.issue=6&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2014.22
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-03-01
N1 - Last updated - 2016-03-30
N1 - SubjectsTermNotLitGenreText - Inventories; Chromium; Heavy metals; Nickel; Occupational exposure; Mathematics; Sensitivity; Historical account; Metals; Urine; Metal finishing industry; China, People's Rep., Shanghai
DO - http://dx.doi.org/10.1038/jes.2014.22
ER -
TY - JOUR
T1 - A Research on the Relationship between Exercise Behavior of the Elderly and Medical Frequency as well as Quality of Life
AN - 1660394907; PQ0001022306
AB - Purpose: To understand the impact of exercise frequency (per week of the elderly) on medical inspection frequency and quality of life. Method: Conduct an investigation through questionnaire survey method, aiming at people over 65. Descriptive statistics, t-test, and one-way ANOVA were used to analyze the data including 898 valid questionnaires. Result: 1. Elderly whose exercise more than 5 days a week get higher score in Physical Component Summary (PCS) and Mental Component Summary (MCS), and the inspection frequency was low. 2. The significant differences on medical inspection frequency exist in variables such as exercise frequency, gender, age, hospitalized or not, suffer from chronic diseases or not, and work or not. 3. The medical inspection frequency show sudden deterioration after the age of 75, which means that the age of 75 is a key age point. Conclusion: Elders whose exercise more than 3 days a week only perform better in MCS. However, if the number of days of doing exercise reaches 5 days a week, it will get better scores in not only MCS and PCS, but also reduce the number of medical inspection frequency. We suggest the elderly people should exercise more than five days a week to reduce the medical visits, and enhance the quality of life.
JF - Tiyu Keyan/Sports Science Research
AU - Kao, Hsingkuei
AU - Liu, Zhimin
AD - Taipei Municipal Nei-Hu Junior High School, Taipei, China
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 17
EP - 22
PB - Shanghai Research Institute of Sports Science, 87 Wu Xing Rd. Shanghai 200030 China, [mailto:shtyky@online.sh.cn], [URL:http://www.shriss.cn]
VL - 35
IS - 6
SN - 1006-1207, 1006-1207
KW - Physical Education Index
KW - Age
KW - Statistics
KW - Research (statistical design)
KW - Gerontology
KW - Surveys
KW - Lifestyle
KW - scoring
KW - Exercise (frequency)
KW - PE 030:Exercise, Health & Physical Fitness
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660394907?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tiyu+Keyan%2FSports+Science+Research&rft.atitle=A+Research+on+the+Relationship+between+Exercise+Behavior+of+the+Elderly+and+Medical+Frequency+as+well+as+Quality+of+Life&rft.au=Kao%2C+Hsingkuei%3BLiu%2C+Zhimin&rft.aulast=Kao&rft.aufirst=Hsingkuei&rft.date=2014-11-01&rft.volume=35&rft.issue=6&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Tiyu+Keyan%2FSports+Science+Research&rft.issn=10061207&rft_id=info:doi/
LA - Chinese
DB - Physical Education Index
N1 - Date revised - 2015-03-01
N1 - Last updated - 2015-11-16
N1 - SubjectsTermNotLitGenreText - Age; Statistics; Research (statistical design); Gerontology; Surveys; Exercise (frequency); scoring; Lifestyle
ER -
TY - JOUR
T1 - A bilingual-monolingual comparison of young children's vocabulary size: Evidence from comprehension and production
AN - 1660000349; llba-201501679
AB - It is often assumed that young bilinguals are lexically delayed in comparison to monolinguals. A comprehensive comparison of comprehension and production vocabulary in 31 firstborn bilingual and 30 matched monolingual children fails to find empirical foundation for this assumption. Several raters completed Dutch and French adaptations of the MacArthur Communicative Development Inventories for children aged 13 and 20 months. At 13 months, bilinguals understood more words than did monolinguals; at 20 months, monolinguals knew more Dutch words than did bilinguals (combining comprehension and production). There were no group differences for word production or for Dutch word comprehension. Both groups understood and produced the same number of lexicalized meanings; ratios of word comprehension to word production did not differ; interindividual variation was similar. This study underscores the importance of conducting bilingual-monolingual comparisons with matched groups and suggests that if individual bilingual children appear to be slow in early vocabulary development, reasons other than their bilingualism should be investigated. Adapted from the source document
JF - Applied Psycholinguistics
AU - De Houwer, Annick
AU - Bornstein, Marc H
AU - Putnick, Diane L
AD - Erfurt University and Eunice Kennedy Shriver National Institute of Child Health and Human Development annick.dehouwer@uni-erfurt.de
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 1189
EP - 1211
VL - 35
IS - 6
SN - 0142-7164, 0142-7164
KW - *Comprehension (13950)
KW - *Dutch (20100)
KW - *Bilingualism (08850)
KW - *Children (11850)
KW - *Language Acquisition (41600)
KW - *Monolingualism (54850)
KW - *French (25750)
KW - *Vocabulary Size (94862)
KW - article
KW - 4026: psycholinguistics; bilingual language processing
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660000349?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Psycholinguistics&rft.atitle=A+bilingual-monolingual+comparison+of+young+children%27s+vocabulary+size%3A+Evidence+from+comprehension+and+production&rft.au=De+Houwer%2C+Annick%3BBornstein%2C+Marc+H%3BPutnick%2C+Diane+L&rft.aulast=De+Houwer&rft.aufirst=Annick&rft.date=2014-11-01&rft.volume=35&rft.issue=6&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Applied+Psycholinguistics&rft.issn=01427164&rft_id=info:doi/
LA - English
DB - ComDisDome
N1 - Date revised - 2015-03-01
N1 - Last updated - 2015-03-03
N1 - CODEN - APPSDZ
N1 - SubjectsTermNotLitGenreText - *Bilingualism (08850); *Comprehension (13950); *Children (11850); *Dutch (20100); *Monolingualism (54850); *Vocabulary Size (94862); *French (25750); *Language Acquisition (41600)
ER -
TY - JOUR
T1 - Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter
AN - 1647013778; 21276148
AB - Genomic engineering by the guide RNA (gRNA)-directed CRISPR/CAS9 is rapidly becoming a method of choice for various biological systems. However, pressing concerns remain regarding its off-target activities and wide variations in efficacies. While next generation sequencing (NGS) has been primarily used to evaluate the efficacies and off-target activities of gRNAs, it only detects the imperfectly repaired double strand DNA breaks (DSB) by the error-prone non-homologous end joining (NHEJ) mechanism and may not faithfully represent the DSB activities because the efficiency of NHEJ-mediated repair varies depending on the local chromatin environment. Here we describe a reporter system for unbiased detection and comparison of DSB activities that promises to improve the chance of success in genomic engineering and to facilitate large-scale screening of CAS9 activities and gRNA libraries. Additionally, we demonstrated that the tolerances to mismatches between a gRNA and the corresponding target DNA can occur at any position of the gRNA, and depend on both specific gRNA sequences and CAS9 constructs used.
JF - Journal of Biotechnology
AU - Zhang, Jian-Hua
AU - Pandey, Mritunjay
AU - Kahler, John F
AU - Loshakov, Anna
AU - Harris, Benjamin
AU - Dagur, Pradeep K
AU - Mo, Yin-Yuan
AU - Simonds, William F
AD - Metabolic Diseases Branch, Bldg. 10, Room 8C-101, National Institute of Diabetes and Digestive and Kidney Diseases, United States
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 1
EP - 8
PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands
VL - 189
SN - 0168-1656, 0168-1656
KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts
KW - CRISPR
KW - CAS9
KW - gRNA
KW - EGFP reporter
KW - Specificity
KW - CRISPR clustered regularly interspaced short palindromic repeats
KW - CAS9 CRISPR associated protein
KW - gRNA guide RNA
KW - NHEJ none homologous end joining
KW - DSB double strand DNA break
KW - NGS next generation sequencing
KW - DNA damage
KW - Non-homologous end joining
KW - RNA
KW - Chromatin
KW - Nucleotide sequence
KW - genomics
KW - W 30925:Genetic Engineering
KW - N 14820:DNA Metabolism & Structure
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biotechnology&rft.atitle=Improving+the+specificity+and+efficacy+of+CRISPR%2FCAS9+and+gRNA+through+target+specific+DNA+reporter&rft.au=Zhang%2C+Jian-Hua%3BPandey%2C+Mritunjay%3BKahler%2C+John+F%3BLoshakov%2C+Anna%3BHarris%2C+Benjamin%3BDagur%2C+Pradeep+K%3BMo%2C+Yin-Yuan%3BSimonds%2C+William+F&rft.aulast=Zhang&rft.aufirst=Jian-Hua&rft.date=2014-11-01&rft.volume=189&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biotechnology&rft.issn=01681656&rft_id=info:doi/10.1016%2Fj.jbiotec.2014.08.033
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2015-01-01
N1 - Last updated - 2016-07-20
N1 - SubjectsTermNotLitGenreText - DNA damage; Chromatin; RNA; Non-homologous end joining; Nucleotide sequence; genomics; gRNA
DO - http://dx.doi.org/10.1016/j.jbiotec.2014.08.033
ER -
TY - JOUR
T1 - The First US Domestic Report of Disseminated Mycobacterium avium Complex and Anti-Interferon- gamma Autoantibodies
AN - 1635034209; 21030520
AB - Introduction: Anti-interferon- gamma (IFN gamma ) autoantibodies have been associated with disseminated mycobacterial infections, mostly in patients from Southeast Asia. Purpose: We studied an American-born, Caucasian female with M. avium complex infection of the subglottic mucosa and brain for underlying etiologies of infection. Methods: Plasma was screened for anticytokine autoantibodies using a Luminex-based approach. The ability of patient plasma to block IFN gamma -induced STAT1 phosphorylation in normal blood cells was evaluated by flow cytometry with intracellular staining. Plasma inhibition of IFN gamma production and IFN gamma -induced cytokines in normal and patient blood cells washed of autologous plasma was also evaluated. Results: Patient plasma contained high-titer IgG anti-IFN gamma autoantibodies, primarily of the IgG sub(1) subclass. Patient but not control plasma prevented IFN gamma -induced STAT1 phosphorylation and expression of the IFN gamma -inducible cytokines tumor necrosis factor (TNF) alpha and interleukin (IL)-12 in normal blood cells. Patient blood cells washed free of autologous plasma demonstrated normal IFN gamma production and response. Conclusions: Disseminated nontuberculous mycobacterial infections should always prompt immune evaluation. This first case of disseminated nontuberculous mycobacterial infection and anti-IFN gamma autoantibodies in an American-born Caucasian suggests that anti-cytokine autoantibodies are not racially or regionally restricted.
JF - Journal of Clinical Immunology
AU - O'Connell, Elise
AU - Rosen, Lindsey B
AU - LaRue, Richard W
AU - Fabre, Valeria
AU - Melia, Michael T
AU - Auwaerter, Paul G
AU - Holland, Steven M
AU - Browne, Sarah K
AD - Laboratory of Parasitic Diseases, NIAID, NIH, CRC B3-4141, MSC 1684, Bethesda, MD, 20892-1684, USA, brownesa@niaid.nih.gov
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 928
EP - 932
PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands
VL - 34
IS - 8
SN - 0271-9142, 0271-9142
KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW - Etiology
KW - Mycobacterium avium
KW - Tumor necrosis factor
KW - Mucosa
KW - Brain
KW - Interleukins
KW - Infection
KW - Flow cytometry
KW - Autoantibodies
KW - Phosphorylation
KW - Stat1 protein
KW - Immunoglobulin G
KW - Blood cells
KW - F 06930:Autoimmunity
KW - J 02350:Immunology
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Immunology&rft.atitle=The+First+US+Domestic+Report+of+Disseminated+Mycobacterium+avium+Complex+and+Anti-Interferon-+gamma+Autoantibodies&rft.au=O%27Connell%2C+Elise%3BRosen%2C+Lindsey+B%3BLaRue%2C+Richard+W%3BFabre%2C+Valeria%3BMelia%2C+Michael+T%3BAuwaerter%2C+Paul+G%3BHolland%2C+Steven+M%3BBrowne%2C+Sarah+K&rft.aulast=O%27Connell&rft.aufirst=Elise&rft.date=2014-11-01&rft.volume=34&rft.issue=8&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Immunology&rft.issn=02719142&rft_id=info:doi/10.1007%2Fs10875-014-0073-9
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Number of references - 25
N1 - Last updated - 2015-03-04
N1 - SubjectsTermNotLitGenreText - Flow cytometry; Etiology; Phosphorylation; Autoantibodies; Stat1 protein; Tumor necrosis factor; Mucosa; Interleukins; Brain; Immunoglobulin G; Blood cells; Infection; Mycobacterium avium
DO - http://dx.doi.org/10.1007/s10875-014-0073-9
ER -
TY - JOUR
T1 - Antigen Reversal Identifies Targets of Opsonizing IgGs against Pregnancy-Associated Malaria
AN - 1635034065; 20999613
AB - Clinical immunity to pregnancy associated-malaria (PAM) in multigravida women has been attributed to antibodies that recognize VAR2CSA on the infected erythrocyte (IE) surface. The size and complexity of VAR2CSA have focused efforts on selecting one or more of its six Duffy binding-like (DBL) domains for vaccine development. Presently, however, there is no consensus as to which DBL domain(s) would be most effective in eliciting immunity. This is because antibodies to a number of the DBL domains have been found to block the adhesion of VAR2CSA-expressing erythrocytes to chondroitin sulfate A (CSA)-a major criterion for evaluating vaccine candidacy. Opsonization of IEs by cytophilic antibodies that recognize VAR2CSA represents an important yet understudied effector mechanism in acquired immunity to PAM. To date, no studies have sought to determine the targets of those antibodies. In this study, we found that IgGs from multigravida Malian women showed (i) higher reactivity to recombinant DBL domains by enzyme-linked immunosorbent assay (ELISA), (ii) more binding to VAR2CSA-expressing IEs, and (iii) greater opsonization of these IEs by human monocytic cells than IgGs from malaria-exposed Malian men and malaria-naive American adults. Preincubation of IgGs from multigravida women with recombinant DBL2 chi , DBL3 chi , or DBL5 epsilon domains significantly diminished opsonization of VAR2CSA-expressing IEs by human monocytes. These data identify the DBL2 chi , DBL3 chi , and DBL5 epsilon domains as the primary targets of opsonizing IgGs for the first time. Our study introduces a new approach to determining the antigenic targets of opsonizing IgGs in phagocytosis assays.
JF - Infection and Immunity
AU - Lambert, Lester H
AU - Bullock, Jeanee L
AU - Cook, Sharma T
AU - Miura, Kazutoyo
AU - Garboczi, David N
AU - Diakite, Mahamadou
AU - Fairhurst, Rick M
AU - Singh, Kavita
AU - Long, Carole A
AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA, clong@niaid.nih.gov.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 4842
EP - 4853
PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States
VL - 82
IS - 11
SN - 0019-9567, 0019-9567
KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts
KW - Enzyme-linked immunosorbent assay
KW - Human diseases
KW - Chondroitin sulfate
KW - Data processing
KW - Erythrocytes
KW - Disease control
KW - Malaria
KW - Immunity
KW - Adhesion
KW - Pregnancy
KW - Recombinants
KW - Antibodies
KW - Antigens
KW - Immunoglobulin G
KW - Monocytes
KW - Vaccines
KW - Phagocytosis
KW - Opsonization
KW - K 03300:Methods
KW - Q1 08485:Species interactions: pests and control
KW - F 06910:Microorganisms & Parasites
KW - Q5 08524:Public health, medicines, dangerous organisms
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Number of references - 62
N1 - Last updated - 2016-02-04
N1 - SubjectsTermNotLitGenreText - Recombinants; Human diseases; Antibodies; Erythrocytes; Disease control; Malaria; Vaccines; Immunity; Adhesion; Enzyme-linked immunosorbent assay; Data processing; Chondroitin sulfate; Pregnancy; Antigens; Immunoglobulin G; Monocytes; Phagocytosis; Opsonization
DO - http://dx.doi.org/10.1128/IAI.02097-14
ER -
TY - JOUR
T1 - Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells
AN - 1635025032; 21033297
AB - Binding of polo-like kinase 1 (Plk1) polo-box domains (PBDs) to phosphothreonine (pThr)/phosphoserine (pSer)-containing sequences is critical for the proper function of Plk1. Although high-affinity synthetic pThr-containing peptides provide starting points for developing PBD-directed inhibitors, to date the efficacy of such peptides in whole cell assays has been poor. This potentially reflects limited cell membrane permeability arising, in part, from the di-anionic nature of the phosphoryl group or its mimetics. In our current article we report the unanticipated on-resin N( tau )-alkylation of histidine residues already bearing a N( pi )- alkyl group. This resulted in cationic imidazolium-containing pThr peptides, several of which exhibit single-digit nanomolar PBD-binding affinities in extracellular assays and improved antimitotic efficacies in intact cells. We enhanced the cellular efficacies of these peptides further by applying bio-reversible pivaloyloxymethyl (POM) phosphoryl protection. New structural insights presented in our current study, including the potential utility of intramolecular charge masking, may be useful for the further development of PBD-binding peptides and peptide mimetics. copyright 2014 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 102: 444-455, 2014.
JF - Biopolymers
AU - Qian, Wen-Jian
AU - Park, Jung-Eun
AU - Lim, Dan
AU - Lai, Christopher C
AU - Kelley, James A
AU - Park, Suk-Youl
AU - Lee, Ki Won
AU - Yaffe, Michael B
AU - Lee, Kyung S
AU - Burke, Terrence R
AD - Chemical Biology Laboratory, Center for Cancer Research, National Institutes of Health, NCI at Frederick, Frederick, MD, 21702.
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 444
EP - 455
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 102
IS - 6
SN - 0006-3525, 0006-3525
KW - Biotechnology and Bioengineering Abstracts
KW - Cell membranes
KW - Histidine
KW - polo-like kinase 1
KW - Biopolymers
KW - Membrane permeability
KW - phosphoserine
KW - Alkylation
KW - W 30935:Food Biotechnology
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biopolymers&rft.atitle=Mono-anionic+phosphopeptides+produced+by+unexpected+histidine+alkylation+exhibit+high+plk1+polo-box+domain-binding+affinities+and+enhanced+antiproliferative+effects+in+hela+cells&rft.au=Qian%2C+Wen-Jian%3BPark%2C+Jung-Eun%3BLim%2C+Dan%3BLai%2C+Christopher+C%3BKelley%2C+James+A%3BPark%2C+Suk-Youl%3BLee%2C+Ki+Won%3BYaffe%2C+Michael+B%3BLee%2C+Kyung+S%3BBurke%2C+Terrence+R&rft.aulast=Qian&rft.aufirst=Wen-Jian&rft.date=2014-11-01&rft.volume=102&rft.issue=6&rft.spage=444&rft.isbn=&rft.btitle=&rft.title=Biopolymers&rft.issn=00063525&rft_id=info:doi/10.1002%2Fbip.22569
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Last updated - 2015-03-20
N1 - SubjectsTermNotLitGenreText - Cell membranes; Histidine; Biopolymers; polo-like kinase 1; Membrane permeability; phosphoserine; Alkylation
DO - http://dx.doi.org/10.1002/bip.22569
ER -
TY - JOUR
T1 - Effect of Suberoylanilide Hydroxamic Acid (SAHA) Administration on the Residual Virus Pool in a Model of Combination Antiretroviral Therapy-Mediated Suppression in SIVmac239-Infected Indian Rhesus Macaques
AN - 1635016632; 20999487
AB - Nonhuman primate models are needed for evaluations of proposed strategies targeting residual virus that persists in HIV-1-infected individuals receiving suppressive combination antiretroviral therapy (cART). However, relevant nonhuman primate (NHP) models of cART-mediated suppression have proven challenging to develop. We used a novel three-class, six-drug cART regimen to achieve durable 4.0- to 5.5-log reductions in plasma viremia levels and declines in cell-associated viral RNA and DNA in blood and tissues of simian immunodeficiency virus SIVmac239-infected Indian-origin rhesus macaques, then evaluated the impact of treatment with the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA; Vorinostat) on the residual virus pool. Ex vivo SAHA treatment of CD4+ T cells obtained from cART-suppressed animals increased histone acetylation and viral RNA levels in culture supernatants. cART-suppressed animals each received 84 total doses of oral SAHA. We observed SAHA dose-dependent increases in acetylated histones with evidence for sustained modulation as well as refractoriness following prolonged administration. In vivo virologic activity was demonstrated based on the ratio of viral RNA to viral DNA in peripheral blood mononuclear cells, a presumptive measure of viral transcription, which significantly increased in SAHA-treated animals. However, residual virus was readily detected at the end of treatment, suggesting that SAHA alone may be insufficient for viral eradication in the setting of suppressive cART. The effects observed were similar to emerging data for repeat-dose SAHA treatment of HIV-infected individuals on cART, demonstrating the feasibility, utility, and relevance of NHP models of cART-mediated suppression for in vivo assessments of AIDS virus functional cure/eradication approaches.
JF - Antimicrobial Agents & Chemotherapy
AU - Del Prete, Gregory Q
AU - Shoemaker, Rebecca
AU - Oswald, Kelli
AU - Lara, Abigail
AU - Trubey, Charles M
AU - Fast, Randy
AU - Schneider, Douglas K
AU - Kiser, Rebecca
AU - Coalter, Vicky
AU - Wiles, Adam
AD - AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA, lifsonj@mail.nih.gov.
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 6790
EP - 6806
PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States
VL - 58
IS - 11
SN - 0066-4804, 0066-4804
KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology
KW - Histone deacetylase
KW - Acquired immune deficiency syndrome
KW - Data processing
KW - antiretroviral therapy
KW - Transcription
KW - Cell culture
KW - Primates
KW - Hydroxamic acid
KW - Acetylation
KW - CD4 antigen
KW - Peripheral blood mononuclear cells
KW - Antiviral agents
KW - RNA
KW - Human immunodeficiency virus
KW - DNA
KW - Lymphocytes T
KW - Macaca mulatta
KW - Viremia
KW - Simian immunodeficiency virus
KW - A 01340:Antibiotics & Antimicrobials
KW - V 22360:AIDS and HIV
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Number of references - 78
N1 - Last updated - 2015-03-04
N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Acquired immune deficiency syndrome; Data processing; antiretroviral therapy; Transcription; Cell culture; Hydroxamic acid; Acetylation; Peripheral blood mononuclear cells; CD4 antigen; RNA; Antiviral agents; Lymphocytes T; DNA; Viremia; Human immunodeficiency virus; Macaca mulatta; Primates; Simian immunodeficiency virus
DO - http://dx.doi.org/10.1128/AAC.03746-14
ER -
TY - JOUR
T1 - Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis
AN - 1635016562; 20999456
AB - We report here a series of five chemically diverse scaffolds that have in vitro activities on replicating and hypoxic nonreplicating bacilli by targeting the respiratory bc1 complex in Mycobacterium tuberculosis in a strain-dependent manner. Deletion of the cytochrome bd oxidase generated a hypersusceptible mutant in which resistance was acquired by a mutation in qcrB. These results highlight the promiscuity of the bc1 complex and the risk of targeting energy metabolism with new drugs.
JF - Antimicrobial Agents & Chemotherapy
AU - Arora, Kriti
AU - Ochoa-Montano, Bernardo
AU - Tsang, Patricia S
AU - Blundell, Tom L
AU - Dawes, Stephanie S
AU - Mizrahi, Valerie
AU - Bayliss, Tracy
AU - Mackenzie, Claire J
AU - Cleghorn, Laura AT
AU - Ray, Peter C
AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA, hboshoff@niaid.nih.gov.
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 6962
EP - 6965
PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States
VL - 58
IS - 11
SN - 0066-4804, 0066-4804
KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology
KW - Bacilli
KW - Gene deletion
KW - Energy metabolism
KW - Drug metabolism
KW - Hypoxia
KW - Cytochrome-c oxidase
KW - cytochrome bd
KW - Mutation
KW - scaffolds
KW - Mycobacterium tuberculosis
KW - A 01340:Antibiotics & Antimicrobials
KW - J 02320:Cell Biology
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Number of references - 19
N1 - Last updated - 2015-03-04
N1 - SubjectsTermNotLitGenreText - Bacilli; Gene deletion; Energy metabolism; Hypoxia; Drug metabolism; cytochrome bd; Cytochrome-c oxidase; Mutation; scaffolds; Mycobacterium tuberculosis
DO - http://dx.doi.org/10.1128/AAC.03486-14
ER -
TY - JOUR
T1 - Structural characterization of the virulence factor nuclease A from Streptococcus agalactiae
AN - 1635014773; 20933097
AB - The group B pathogen Streptococcus agalactiae commonly populates the human gut and urogenital tract, and is a major cause of infection-based mortality in neonatal infants and in elderly or immunocompromised adults. Nuclease A (GBS_NucA), a secreted DNA/RNA nuclease, serves as a virulence factor for S. agalactiae, facilitating bacterial evasion of the human innate immune response. GBS_NucA efficiently degrades the DNA matrix component of neutrophil extracellular traps (NETs), which attempt to kill and clear invading bacteria during the early stages of infection. In order to better understand the mechanisms of DNA substrate binding and catalysis of GBS_NucA, the high-resolution structure of a catalytically inactive mutant (H148G) was solved by X-ray crystallography. Several mutants on the surface of GBS_NucA which might influence DNA substrate binding and catalysis were generated and evaluated using an imidazole chemical rescue technique. While several of these mutants severely inhibited nuclease activity, two mutants (K146R and Q183A) exhibited significantly increased activity. These structural and biochemical studies have greatly increased our understanding of the mechanism of action of GBS_NucA in bacterial virulence and may serve as a foundation for the structure-based drug design of antibacterial compounds targeted to S. agalactiae.
JF - Acta Crystallographica Section D
AU - Moon, Andrea F
AU - Gaudu, Philippe
AU - Pedersen, Lars C
AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Y1 - 2014/11/01/
PY - 2014
DA - 2014 Nov 01
SP - 2937
EP - 2949
PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States
VL - 70
IS - 11
SN - 1399-0047, 1399-0047
KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids
KW - Mortality
KW - imidazole
KW - virulence factors
KW - Leukocytes (neutrophilic)
KW - Nuclease
KW - Drug development
KW - Pathogens
KW - Infection
KW - X-ray crystallography
KW - Digestive tract
KW - RNA
KW - Streptococcus agalactiae
KW - Geriatrics
KW - DNA
KW - Immune response
KW - Neonates
KW - Catalysis
KW - Infants
KW - N 14830:RNA
KW - J 02340:Antibiotics & Antimicrobials
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635014773?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+D&rft.atitle=Structural+characterization+of+the+virulence+factor+nuclease+A+from+Streptococcus+agalactiae&rft.au=Moon%2C+Andrea+F%3BGaudu%2C+Philippe%3BPedersen%2C+Lars+C&rft.aulast=Moon&rft.aufirst=Andrea&rft.date=2014-11-01&rft.volume=70&rft.issue=11&rft.spage=2937&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+D&rft.issn=13990047&rft_id=info:doi/10.1107%2FS1399004714019725
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-12-01
N1 - Document feature - figure 0
N1 - Last updated - 2015-03-20
N1 - SubjectsTermNotLitGenreText - Mortality; imidazole; virulence factors; Leukocytes (neutrophilic); Nuclease; Drug development; Pathogens; Infection; X-ray crystallography; Digestive tract; RNA; DNA; Geriatrics; Neonates; Immune response; Infants; Catalysis; Streptococcus agalactiae
DO - http://dx.doi.org/10.1107/S1399004714019725
ER -
TY - JOUR
T1 - Optimizing dosing of oncology drugs.
AN - 1635012184; 25105705
AB - The purpose of this article is to acknowledge the challenges in optimizing the dosing of oncology drugs and to propose potential approaches to address these challenges in order to optimize effectiveness, minimize toxicity, and promote adherence in patients. These approaches could provide better opportunities to understand the sources of variability in drug exposure and clinical outcomes during the development and premarketing evaluation of investigational new drugs.
JF - Clinical pharmacology and therapeutics
AU - Minasian, L
AU - Rosen, O
AU - Auclair, D
AU - Rahman, A
AU - Pazdur, R
AU - Schilsky, R L
AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA. ; Millennium: The Takeda Oncology Company, Cambridge, Massachusetts, USA. ; Multiple Myeloma Research Foundation, Norwalk, Connecticut, USA. ; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. ; American Society of Clinical Oncology, Alexandria, Virginia, USA.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 572
EP - 579
VL - 96
IS - 5
KW - Antineoplastic Agents
KW - 0
KW - Abridged Index Medicus
KW - Index Medicus
KW - Medication Adherence
KW - Dose-Response Relationship, Drug
KW - Humans
KW - Time Factors
KW - Antineoplastic Agents -- administration & dosage
KW - Antineoplastic Agents -- adverse effects
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Optimizing+dosing+of+oncology+drugs.&rft.au=Minasian%2C+L%3BRosen%2C+O%3BAuclair%2C+D%3BRahman%2C+A%3BPazdur%2C+R%3BSchilsky%2C+R+L&rft.aulast=Minasian&rft.aufirst=L&rft.date=2014-11-01&rft.volume=96&rft.issue=5&rft.spage=572&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2014.153
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-02-23
N1 - Date created - 2014-10-22
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1038/clpt.2014.153
ER -
TY - JOUR
T1 - A wedge-based approach to estimating health co-benefits of climate change mitigation activities in the United States
AN - 1627985248; 20926036
AB - While it has been recognized that actions reducing greenhouse gas (GHG) emissions can have significant positive and negative impacts on human health through reductions in ambient fine particulate matter (PM sub(2.5)) concentrations, these impacts are rarely taken into account when analyzing specific policies. This study presents a new framework for estimating the change in health outcomes resulting from implementation of specific carbon dioxide (CO sub(2)) reduction activities, allowing comparison of different sectors and options for climate mitigation activities. Our estimates suggest that in the year 2020, the reductions in adverse health outcomes from lessened exposure to PM sub(2.5) would yield economic benefits in the range of $6 to $30 billion (in 2008 USD), depending on the specific activity. This equates to between $40 and $198 per metric ton of CO sub(2) in health benefits. Specific climate interventions will vary in the health co-benefits they provide as well as in potential harms that may result from their implementation. Rigorous assessment of these health impacts is essential for guiding policy decisions as efforts to reduce GHG emissions increase in scope and intensity.
JF - Climatic Change
AU - Balbus, John M
AU - Greenblatt, Jeffery B
AU - Chari, Ramya
AU - Millstein, Dev
AU - Ebi, Kristie L
AD - National Institute of Environmental Health Sciences, 31 Center Drive, Room B1C02, Bethesda, MD, 20892-2256, USA, john.balbus@nih.gov
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 199
EP - 210
PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands
VL - 127
IS - 2
SN - 0165-0009, 0165-0009
KW - ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; Environment Abstracts; Pollution Abstracts; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts
KW - Mitigation
KW - Climate change
KW - Intervention
KW - Particulates
KW - Public health
KW - Particulate matter in atmosphere
KW - Economics
KW - Particle size
KW - Policies
KW - Atmospheric pollution
KW - Climate
KW - Greenhouse effect
KW - Suspended particulate matter
KW - USA
KW - Particulate matter emissions
KW - Greenhouse gases
KW - Carbon dioxide
KW - Environment management
KW - Economic benefits
KW - H 6000:Natural Disasters/Civil Defense/Emergency Management
KW - M2 551.583:Variations (551.583)
KW - P 0000:AIR POLLUTION
KW - M3 1010:Issues in Sustainable Development
KW - Q5 08504:Effects on organisms
KW - ENA 01:Air Pollution
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627985248?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Climatic+Change&rft.atitle=A+wedge-based+approach+to+estimating+health+co-benefits+of+climate+change+mitigation+activities+in+the+United+States&rft.au=Balbus%2C+John+M%3BGreenblatt%2C+Jeffery+B%3BChari%2C+Ramya%3BMillstein%2C+Dev%3BEbi%2C+Kristie+L&rft.aulast=Balbus&rft.aufirst=John&rft.date=2014-11-01&rft.volume=127&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Climatic+Change&rft.issn=01650009&rft_id=info:doi/10.1007%2Fs10584-014-1262-5
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-01
N1 - Number of references - 21
N1 - Last updated - 2016-12-22
N1 - SubjectsTermNotLitGenreText - Policies; Climate change; Greenhouse effect; Suspended particulate matter; Carbon dioxide; Environment management; Economic benefits; Public health; Particulate matter in atmosphere; Atmospheric pollution; Particulate matter emissions; Greenhouse gases; Particle size; Mitigation; Climate; Economics; Intervention; Particulates; USA
DO - http://dx.doi.org/10.1007/s10584-014-1262-5
ER -
TY - JOUR
T1 - Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.
AN - 1622060911; 25269644
AB - Viral infection triggers innate immune signaling, which in turn induces interferon-β (IFN-β) production to establish innate antiviral immunity. Previous studies showed that Gcn5 (Kat2a), a histone acetyltransferase (HAT) with partial functional redundancy with PCAF (Kat2b), and Gcn5/PCAF-mediated histone H3K9 acetylation (H3K9ac) are enriched on the active IFNB gene promoter. However, whether Gcn5/PCAF and H3K9ac regulate IFN-β production is unknown. Here, we show that Gcn5/PCAF-mediated H3K9ac correlates well with, but is surprisingly dispensable for, the expression of endogenous IFNB and the vast majority of active genes in fibroblasts. Instead, Gcn5/PCAF repress IFN-β production and innate antiviral immunity in several cell types in a HAT-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 in the cytoplasm. Our results thus identify Gcn5 and PCAF as negative regulators of IFN-β production and innate immune signaling.
© 2014 The Authors.
JF - EMBO reports
AU - Jin, Qihuang
AU - Zhuang, Lenan
AU - Lai, Binbin
AU - Wang, Chaochen
AU - Li, Wenqian
AU - Dolan, Brian
AU - Lu, Yue
AU - Wang, Zhibin
AU - Zhao, Keji
AU - Peng, Weiqun
AU - Dent, Sharon Y R
AU - Ge, Kai
AD - Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA Department of Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Smithville, TX, USA. ; Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA. ; Department of Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Smithville, TX, USA. ; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. ; Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA. ; Department of Physics, The George Washington University, Washington, DC, USA. ; Department of Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Smithville, TX, USA sroth@mdanderson.org kaig@niddk.nih.gov. ; Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA sroth@mdanderson.org kaig@niddk.nih.gov.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 1192
EP - 1201
VL - 15
IS - 11
KW - Histones
KW - 0
KW - Interferon-beta
KW - 77238-31-4
KW - p300-CBP Transcription Factors
KW - EC 2.3.1.48
KW - p300-CBP-associated factor
KW - Protein-Serine-Threonine Kinases
KW - EC 2.7.11.1
KW - TBK1 protein, human
KW - Index Medicus
KW - H3K9ac
KW - TBK1
KW - interferon‐β
KW - Gcn5/PCAF
KW - innate immune signaling
KW - Fibroblasts -- immunology
KW - Acetylation
KW - Humans
KW - Histones -- metabolism
KW - HEK293 Cells
KW - Immunity, Innate
KW - Protein Binding
KW - Fibroblasts -- metabolism
KW - Protein-Serine-Threonine Kinases -- metabolism
KW - Interferon-beta -- metabolism
KW - p300-CBP Transcription Factors -- metabolism
KW - p300-CBP Transcription Factors -- genetics
KW - Protein-Serine-Threonine Kinases -- genetics
KW - Interferon-beta -- genetics
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622060911?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+reports&rft.atitle=Gcn5+and+PCAF+negatively+regulate+interferon-%CE%B2+production+through+HAT-independent+inhibition+of+TBK1.&rft.au=Jin%2C+Qihuang%3BZhuang%2C+Lenan%3BLai%2C+Binbin%3BWang%2C+Chaochen%3BLi%2C+Wenqian%3BDolan%2C+Brian%3BLu%2C+Yue%3BWang%2C+Zhibin%3BZhao%2C+Keji%3BPeng%2C+Weiqun%3BDent%2C+Sharon+Y+R%3BGe%2C+Kai&rft.aulast=Jin&rft.aufirst=Qihuang&rft.date=2014-11-01&rft.volume=15&rft.issue=11&rft.spage=1192&rft.isbn=&rft.btitle=&rft.title=EMBO+reports&rft.issn=1469-3178&rft_id=info:doi/10.15252%2Fembr.201438990
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-08
N1 - Date created - 2014-11-07
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
J Biol Chem. 2002 Apr 19;277(16):13840-7 [11839743]
Elife. 2013;2:e01503 [24368734]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.15252/embr.201438990
ER -
TY - JOUR
T1 - Safety of in utero and neonatal antiretroviral exposure: cognitive and academic outcomes in HIV-exposed, uninfected children 5-13 years of age.
AN - 1619318519; 25361407
AB - Long-term effects of in utero and neonatal antiretroviral (ARV) exposure on cognitive and academic development in HIV-exposed, uninfected school-age children are unknown.
HIV-exposed, uninfected children, ages 5-13 years, in Pediatric HIV/AIDS Cohort Study Surveillance Monitoring for Antiretroviral Treatment Toxicities, a US-based multisite cohort study, completed age-appropriate Wechsler intelligence and academic scales (WPPSI-III, WASI, WIAT-II-A). Associations between cognitive and academic outcomes and in utero ARV exposure by regimen, class and individual ARVs were evaluated, adjusting for potential confounders. Children completing WPPSI-IIIs (n = 350) were 49% male, 74% Black, 25% Hispanic; WASI (n = 337) and WIAT-II-A (n = 415) cohorts were similar. The percentage exposed to combination ARV (cARV) was 84% (WPPSI-III), 64% (WASI) and 67% (WIAT-II-A). Among ARV-exposed children, there were no significant associations between any ARV regimen or class and any cognitive or academic outcome. In addition, in both unadjusted models and after adjustment for caregiver IQ, sociodemographic factors and maternal health and substance use during pregnancy, no individual ARV drug was associated with significantly lower cognitive or academic scores. Factors typically associated with lower cognitive and academic scores in the general population, such as prematurity, small for gestational age, maternal alcohol use and lower maternal cognitive status, were also associated with lower scores in this study.
Overall, the safety of prenatal and neonatal ARV use was supported.
JF - The Pediatric infectious disease journal
AU - Nozyce, Molly L
AU - Huo, Yanling
AU - Williams, Paige L
AU - Kapetanovic, Suad
AU - Hazra, Rohan
AU - Nichols, Sharon
AU - Hunter, Scott
AU - Smith, Renee
AU - Seage, George R
AU - Sirois, Patricia A
AU - Pediatric HIVAIDS Cohort Study
AD - From the *Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY; †Harvard School of Public Health, Boston, MA; ‡National Institute of Mental Health, Bethesda; §Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD; ¶University of California, San Diego, CA; ‖University of Chicago; **University of Illinois, Chicago, IL; ††Tulane University School of Medicine, New Orleans, LA. ; Pediatric HIVAIDS Cohort Study
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 1128
EP - 1133
VL - 33
IS - 11
KW - Anti-Retroviral Agents
KW - 0
KW - Index Medicus
KW - Wechsler Scales
KW - Drug Therapy, Combination
KW - Educational Status
KW - Humans
KW - Infant, Newborn
KW - Child Development
KW - Child
KW - Adolescent
KW - Male
KW - Female
KW - Pregnancy
KW - Child, Preschool
KW - Infectious Disease Transmission, Vertical -- prevention & control
KW - Intelligence -- drug effects
KW - HIV Infections -- transmission
KW - HIV Infections -- drug therapy
KW - Anti-Retroviral Agents -- adverse effects
KW - Pregnancy Complications, Infectious -- drug therapy
KW - Prenatal Exposure Delayed Effects
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Pediatric+infectious+disease+journal&rft.atitle=Safety+of+in+utero+and+neonatal+antiretroviral+exposure%3A+cognitive+and+academic+outcomes+in+HIV-exposed%2C+uninfected+children+5-13+years+of+age.&rft.au=Nozyce%2C+Molly+L%3BHuo%2C+Yanling%3BWilliams%2C+Paige+L%3BKapetanovic%2C+Suad%3BHazra%2C+Rohan%3BNichols%2C+Sharon%3BHunter%2C+Scott%3BSmith%2C+Renee%3BSeage%2C+George+R%3BSirois%2C+Patricia+A%3BPediatric+HIVAIDS+Cohort+Study&rft.aulast=Nozyce&rft.aufirst=Molly&rft.date=2014-11-01&rft.volume=33&rft.issue=11&rft.spage=1128&rft.isbn=&rft.btitle=&rft.title=The+Pediatric+infectious+disease+journal&rft.issn=1532-0987&rft_id=info:doi/10.1097%2FINF.0000000000000410
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-10-28
N1 - Date created - 2014-11-01
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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Pediatr Infect Dis J. 2013 Jun;32(6):648-55 [23340561]
Pediatrics. 2012 Nov;130(5):e1326-44 [23118140]
Pediatr Infect Dis J. 2012 Jun;31(6):592-8 [22592486]
AIDS Patient Care STDS. 2011 Jul;25(7):385-94 [21992592]
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J Acquir Immune Defic Syndr. 2011 Jul 1;57(3):218-22 [21372725]
Lancet. 1999 Sep 25;354(9184):1084-9 [10509500]
Neurotoxicol Teratol. 2005 Jan-Feb;27(1):169-73 [15681130]
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Pediatrics. 2006 Oct;118(4):e1139-45 [16940166]
Pediatrics. 2007 Mar;119(3):e681-93 [17296781]
Drug Saf. 2007;30(3):203-13 [17343429]
AIDS. 2007 May 11;21(8):929-38 [17457086]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1097/INF.0000000000000410
ER -
TY - JOUR
T1 - Preclinical activity of the liposomal cisplatin lipoplatin in ovarian cancer.
AN - 1619318046; 25231401
AB - Cisplatin and its platinum derivatives are first-line chemotherapeutic agents in the treatment of ovarian cancer; however, treatment is associated with tumor resistance and significant toxicity. Here we investigated the antitumoral activity of lipoplatin, one of the most promising liposomal platinum drug formulations under clinical investigation.
In vitro effects of lipoplatin were tested on a panel of ovarian cancer cell lines, sensitive and resistant to cisplatin, using both two-dimensional (2D) and 3D cell models. We evaluated in vivo the lipoplatin anticancer activity using tumor xenografts. Lipoplatin exhibited a potent antitumoral activity in all ovarian cancer cell lines tested, induced apoptosis, and activated caspase-9, -8, and -3, downregulating Bcl-2 and upregulating Bax. Lipoplatin inhibited thioredoxin reductase enzymatic activity and increased reactive oxygen species accumulation and reduced EGF receptor (EGFR) expression and inhibited cell invasion. Lipoplatin demonstrated a synergistic effect when used in combination with doxorubicin, widely used in relapsed ovarian cancer treatment, and with the albumin-bound paclitaxel, Abraxane. Lipoplatin decreased both ALDH and CD133 expression, markers of ovarian cancer stem cells. Multicellular aggregates/spheroids are present in ascites of patients and most contribute to the spreading to secondary sites. Lipoplatin decreased spheroids growth, vitality, and cell migration out of preformed spheroids. Finally, lipoplatin inhibited more than 90% tumor xenograft growth with minimal systemic toxicity, and after the treatment suspension, no tumor progression was observed.
These preclinical data suggest that lipoplatin has potential for clinical assessment in aggressive cisplatin-resistant patients with ovarian cancer. ©2014 American Association for Cancer Research.
JF - Clinical cancer research : an official journal of the American Association for Cancer Research
AU - Casagrande, Naike
AU - Celegato, Marta
AU - Borghese, Cinzia
AU - Mongiat, Maurizio
AU - Colombatti, Alfonso
AU - Aldinucci, Donatella
AD - Experimental Oncology 2, CRO Aviano National Cancer Institute, Aviano, Italy. ; Experimental Oncology 2, CRO Aviano National Cancer Institute, Aviano, Italy. Department of Medical and Biological Science Technology and MATI (Microgravity Ageing Training Immobility) Excellence Center, University of Udine, Udine, Italy. ; Experimental Oncology 2, CRO Aviano National Cancer Institute, Aviano, Italy. daldinucci@cro.it.
Y1 - 2014/11/01/
PY - 2014
DA - 2014 Nov 01
SP - 5496
EP - 5506
VL - 20
IS - 21
SN - 1078-0432, 1078-0432
KW - AC133 Antigen
KW - 0
KW - Albumin-Bound Paclitaxel
KW - Albumins
KW - Antigens, CD
KW - Antineoplastic Agents
KW - Glycoproteins
KW - Liposomes
KW - PROM1 protein, human
KW - Peptides
KW - Proto-Oncogene Proteins c-bcl-2
KW - Reactive Oxygen Species
KW - bcl-2-Associated X Protein
KW - lipoplatin
KW - Doxorubicin
KW - 80168379AG
KW - EGFR protein, human
KW - EC 2.7.10.1
KW - Receptor, Epidermal Growth Factor
KW - Caspases
KW - EC 3.4.22.-
KW - Paclitaxel
KW - P88XT4IS4D
KW - Cisplatin
KW - Q20Q21Q62J
KW - Index Medicus
KW - Spheroids, Cellular -- metabolism
KW - Reactive Oxygen Species -- metabolism
KW - Humans
KW - Antigens, CD -- genetics
KW - Paclitaxel -- pharmacology
KW - Caspases -- genetics
KW - Neoplasm Invasiveness -- genetics
KW - Caspases -- metabolism
KW - bcl-2-Associated X Protein -- genetics
KW - Doxorubicin -- pharmacology
KW - Spheroids, Cellular -- drug effects
KW - Drug Resistance, Neoplasm -- genetics
KW - Up-Regulation -- drug effects
KW - Cell Movement -- drug effects
KW - Down-Regulation -- drug effects
KW - Receptor, Epidermal Growth Factor -- metabolism
KW - Albumins -- pharmacology
KW - Peptides -- metabolism
KW - Up-Regulation -- genetics
KW - Cell Line, Tumor
KW - Cell Movement -- genetics
KW - Glycoproteins -- genetics
KW - bcl-2-Associated X Protein -- metabolism
KW - Receptor, Epidermal Growth Factor -- genetics
KW - Down-Regulation -- genetics
KW - Glycoproteins -- metabolism
KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism
KW - Antigens, CD -- metabolism
KW - Peptides -- genetics
KW - Proto-Oncogene Proteins c-bcl-2 -- genetics
KW - Antineoplastic Agents -- pharmacology
KW - Female
KW - Drug Resistance, Neoplasm -- drug effects
KW - Ovarian Neoplasms -- metabolism
KW - Ovarian Neoplasms -- genetics
KW - Cisplatin -- pharmacology
KW - Liposomes -- pharmacology
KW - Ovarian Neoplasms -- drug therapy
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-01
N1 - Date created - 2014-11-01
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-0713
ER -
TY - JOUR
T1 - RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex.
AN - 1619317860; 24942867
AB - RECQL4, a member of the RecQ helicase family, is a multifunctional participant in DNA metabolism. RECQL4 protein participates in several functions both in the nucleus and in the cytoplasm of the cell, and mutations in human RECQL4 are associated with three genetic disorders: Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. We previously reported that RECQL4 is recruited to laser-induced DNA double-strand breaks (DSB). Here, we have characterized the functional roles of RECQL4 in the non-homologous end joining (NHEJ) pathway of DSB repair. In an in vitro NHEJ assay that depends on the activity of DNA-dependent protein kinase (DNA-PK), extracts from RECQL4 knockdown cells display reduced end-joining activity on DNA substrates with cohesive and non-cohesive ends. Depletion of RECQL4 also reduced the end joining activity on a GFP reporter plasmid in vivo. Knockdown of RECQL4 increased the sensitivity of cells to γ-irradiation and resulted in accumulation of 53BP1 foci after irradiation, indicating defects in the processing of DSB. We find that RECQL4 interacts with the Ku70/Ku80 heterodimer, part of the DNA-PK complex, via its N-terminal domain. Further, RECQL4 stimulates higher order DNA binding of Ku70/Ku80 to a blunt end DNA substrate. Taken together, these results implicate that RECQL4 participates in the NHEJ pathway of DSB repair via a functional interaction with the Ku70/Ku80 complex. This is the first study to provide both in vitro and in vivo evidence for a role of a RecQ helicase in NHEJ.
Published by Oxford University Press 2014.
JF - Carcinogenesis
AU - Shamanna, Raghavendra A
AU - Singh, Dharmendra Kumar
AU - Lu, Huiming
AU - Mirey, Gladys
AU - Keijzers, Guido
AU - Salles, Bernard
AU - Croteau, Deborah L
AU - Bohr, Vilhelm A
AD - Laboratory of Molecular Gerontology, Biomedical Research Center, National Institute on Aging, NIH, 251 Bayview Boulevard, Baltimore, MD 21224, USA, INRA, Université de Toulouse, UMR1331, Toxalim, Research Centre in Food Toxicology, F-31027 Toulouse, France and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark. ; INRA, Université de Toulouse, UMR1331, Toxalim, Research Centre in Food Toxicology, F-31027 Toulouse, France and. ; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark. ; Laboratory of Molecular Gerontology, Biomedical Research Center, National Institute on Aging, NIH, 251 Bayview Boulevard, Baltimore, MD 21224, USA, INRA, Université de Toulouse, UMR1331, Toxalim, Research Centre in Food Toxicology, F-31027 Toulouse, France and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark vbohr@nih.gov.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 2415
EP - 2424
VL - 35
IS - 11
KW - Antigens, Nuclear
KW - 0
KW - DNA-Binding Proteins
KW - Intracellular Signaling Peptides and Proteins
KW - TP53BP1 protein, human
KW - Tumor Suppressor p53-Binding Protein 1
KW - DNA-Activated Protein Kinase
KW - EC 2.7.11.1
KW - RECQL4 protein, human
KW - EC 3.6.1.-
KW - RecQ Helicases
KW - EC 3.6.4.12
KW - Xrcc6 protein, human
KW - Ku Autoantigen
KW - EC 4.2.99.-
KW - Index Medicus
KW - Intracellular Signaling Peptides and Proteins -- genetics
KW - DNA-Activated Protein Kinase -- genetics
KW - Gene Knockdown Techniques
KW - Gamma Rays
KW - HeLa Cells
KW - Humans
KW - DNA Breaks, Double-Stranded -- radiation effects
KW - Radiation Tolerance -- genetics
KW - Rothmund-Thomson Syndrome -- genetics
KW - DNA-Binding Proteins -- genetics
KW - RecQ Helicases -- genetics
KW - DNA End-Joining Repair -- genetics
KW - Antigens, Nuclear -- genetics
KW - RecQ Helicases -- antagonists & inhibitors
KW - Rothmund-Thomson Syndrome -- pathology
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=RECQ+helicase+RECQL4+participates+in+non-homologous+end+joining+and+interacts+with+the+Ku+complex.&rft.au=Shamanna%2C+Raghavendra+A%3BSingh%2C+Dharmendra+Kumar%3BLu%2C+Huiming%3BMirey%2C+Gladys%3BKeijzers%2C+Guido%3BSalles%2C+Bernard%3BCroteau%2C+Deborah+L%3BBohr%2C+Vilhelm+A&rft.aulast=Shamanna&rft.aufirst=Raghavendra&rft.date=2014-11-01&rft.volume=35&rft.issue=11&rft.spage=2415&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgu137
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-03-13
N1 - Date created - 2014-11-01
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/carcin/bgu137
ER -
TY - JOUR
T1 - Definition of smad3 phosphorylation events that affect malignant and metastatic behaviors in breast cancer cells.
AN - 1619317779; 25205100
AB - Smad3, a major intracellular mediator of TGFβ signaling, functions as both a positive and negative regulator in carcinogenesis. In response to TGFβ, the TGFβ receptor phosphorylates serine residues at the Smad3 C-tail. Cancer cells often contain high levels of the MAPK and CDK activities, which can lead to the Smad3 linker region becoming highly phosphorylated. Here, we report, for the first time, that mutation of the Smad3 linker phosphorylation sites markedly inhibited primary tumor growth, but significantly increased lung metastasis of breast cancer cell lines. In contrast, mutation of the Smad3 C-tail phosphorylation sites had the opposite effect. We show that mutation of the Smad3 linker phosphorylation sites greatly intensifies all TGFβ-induced responses, including growth arrest, apoptosis, reduction in the size of putative cancer stem cell population, epithelial-mesenchymal transition, and invasive activity. Moreover, all TGFβ responses were completely lost on mutation of the Smad3 C-tail phosphorylation sites. Our results demonstrate a critical role of the counterbalance between the Smad3 C-tail and linker phosphorylation in tumorigenesis and metastasis. Our findings have important implications for therapeutic intervention of breast cancer.
©2014 American Association for Cancer Research.
JF - Cancer research
AU - Bae, Eunjin
AU - Sato, Misako
AU - Kim, Ran-Ju
AU - Kwak, Mi-Kyung
AU - Naka, Kazuhito
AU - Gim, Jungsoo
AU - Kadota, Mitsutaka
AU - Tang, Binwu
AU - Flanders, Kathleen C
AU - Kim, Tae-Aug
AU - Leem, Sun-Hee
AU - Park, Taesung
AU - Liu, Fang
AU - Wakefield, Lalage M
AU - Kim, Seong-Jin
AU - Ooshima, Akira
AD - CHA Cancer Research Institute, CHA University, Seoul, Korea. ; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland. ; Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan. ; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea. ; Genome Resource and Analysis Unit, RIKEN Center for Developmental Biology, Kobe, Japan. ; Department of Biology and Biomedical Science, Dong-A University, Busan, Korea. ; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea. Department of Statistics, Seoul National University, Seoul, Korea. ; Center for Advanced Biotechnology and Medicine, Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, New Jersey. ; CHA Cancer Research Institute, CHA University, Seoul, Korea. aooshima@cha.ac.kr kimsj@cha.ac.kr. ; CHA Cancer Research Institute, CHA University, Seoul, Korea. Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland. aooshima@cha.ac.kr kimsj@cha.ac.kr.
Y1 - 2014/11/01/
PY - 2014
DA - 2014 Nov 01
SP - 6139
EP - 6149
VL - 74
IS - 21
KW - Receptors, Transforming Growth Factor beta
KW - 0
KW - SMAD3 protein, human
KW - Smad3 Protein
KW - Transforming Growth Factor beta
KW - Index Medicus
KW - Receptors, Transforming Growth Factor beta -- genetics
KW - Humans
KW - Receptors, Transforming Growth Factor beta -- metabolism
KW - Cell Line, Tumor
KW - Gene Expression Regulation, Neoplastic
KW - Neoplasm Metastasis -- genetics
KW - Phosphorylation -- genetics
KW - Signal Transduction -- genetics
KW - Xenograft Model Antitumor Assays
KW - Neoplasm Metastasis -- pathology
KW - Transforming Growth Factor beta -- genetics
KW - Transforming Growth Factor beta -- metabolism
KW - Mutation
KW - Female
KW - Breast Neoplasms -- genetics
KW - Breast Neoplasms -- pathology
KW - Smad3 Protein -- metabolism
KW - Epithelial-Mesenchymal Transition -- genetics
KW - Cell Transformation, Neoplastic -- genetics
KW - Smad3 Protein -- genetics
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Definition+of+smad3+phosphorylation+events+that+affect+malignant+and+metastatic+behaviors+in+breast+cancer+cells.&rft.au=Bae%2C+Eunjin%3BSato%2C+Misako%3BKim%2C+Ran-Ju%3BKwak%2C+Mi-Kyung%3BNaka%2C+Kazuhito%3BGim%2C+Jungsoo%3BKadota%2C+Mitsutaka%3BTang%2C+Binwu%3BFlanders%2C+Kathleen+C%3BKim%2C+Tae-Aug%3BLeem%2C+Sun-Hee%3BPark%2C+Taesung%3BLiu%2C+Fang%3BWakefield%2C+Lalage+M%3BKim%2C+Seong-Jin%3BOoshima%2C+Akira&rft.aulast=Bae&rft.aufirst=Eunjin&rft.date=2014-11-01&rft.volume=74&rft.issue=21&rft.spage=6139&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-14-0803
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-01-05
N1 - Date created - 2014-11-01
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1158/0008-5472.CAN-14-0803
ER -
TY - JOUR
T1 - A phase I/II trial of belinostat in combination with cisplatin, doxorubicin, and cyclophosphamide in thymic epithelial tumors: a clinical and translational study.
AN - 1619317602; 25189481
AB - This phase I/II study sought to determine the safety and maximum tolerated dose (MTD) of a novel schedule of belinostat, a histone deacetylase inhibitor (HDAC) administered before and in combination with cisplatin (P), doxorubicin (A), and cyclophosphamide (C) in thymic epithelial tumors (TET). Antitumor activity, pharmacokinetics, and biomarkers of response were also assessed.
Patients with advanced, unresectable TET received increasing doses of belinostat as a continuous intravenous infusion over 48 hours with chemotherapy in 3-week cycles. In phase II, belinostat at the MTD was used. Twenty-six patients were enrolled (thymoma, 12; thymic carcinoma, 14). Dose-limiting toxicities at 2,000 mg/m(2) belinostat were grade 3 nausea and diarrhea and grade 4 neutropenia and thrombocytopenia, respectively, in two patients. Twenty-four patients were treated at the MTD of 1,000 mg/m(2) with chemotherapy (P, 50 mg/m(2) on day 2; A, 25 mg/m(2) on days 2 and 3; C, 500 mg/m(2) on day 3). Objective response rates in thymoma and thymic carcinoma were 64% (95% confidence interval, 30.8%-89.1%) and 21% (4.7%-50.8%), respectively. Modulation of pharmacodynamic markers of HDAC inhibition and declines in regulatory T cell (Treg) and exhausted CD8(+) T-cell populations were observed. Decline in Tregs was associated with response (P = 0.0041) and progression-free survival (P = 0.021). Declines in TIM3(+) CD8(+) T cells were larger in responders than nonresponders (P = 0.049).
This study identified the MTD of belinostat in combination with PAC and indicates that the combination is active and feasible in TETs. Immunomodulatory effects on Tregs and TIM3(+) CD8(+) T cells warrant further study. ©2014 American Association for Cancer Research.
JF - Clinical cancer research : an official journal of the American Association for Cancer Research
AU - Thomas, Anish
AU - Rajan, Arun
AU - Szabo, Eva
AU - Tomita, Yusuke
AU - Carter, Corey A
AU - Scepura, Barbara
AU - Lopez-Chavez, Ariel
AU - Lee, Min-Jung
AU - Redon, Christophe E
AU - Frosch, Ari
AU - Peer, Cody J
AU - Chen, Yuanbin
AU - Piekarz, Richard
AU - Steinberg, Seth M
AU - Trepel, Jane B
AU - Figg, William D
AU - Schrump, David S
AU - Giaccone, Giuseppe
AD - Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland. ; Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland. ; Department of Hematology and Oncology, Walter Reed National Military Medical Center, Bethesda, Maryland. ; Laboratory of Molecular Pharmacology, National Cancer Institute, NIH, Bethesda, Maryland. ; Cancer Therapy Evaluation Program, National Cancer Institute, NIH, Bethesda, Maryland. ; Biostatistics and Data Management Section, National Cancer Institute, NIH, Bethesda, Maryland. ; Thoracic Surgery Section, Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland. ; Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland. gg496@georgetown.edu.
Y1 - 2014/11/01/
PY - 2014
DA - 2014 Nov 01
SP - 5392
EP - 5402
VL - 20
IS - 21
SN - 1078-0432, 1078-0432
KW - Biomarkers, Tumor
KW - 0
KW - Hydroxamic Acids
KW - Sulfonamides
KW - Doxorubicin
KW - 80168379AG
KW - Cyclophosphamide
KW - 8N3DW7272P
KW - belinostat
KW - F4H96P17NZ
KW - Cisplatin
KW - Q20Q21Q62J
KW - Index Medicus
KW - Cyclophosphamide -- administration & dosage
KW - Young Adult
KW - CD8-Positive T-Lymphocytes -- drug effects
KW - Humans
KW - Aged
KW - Translational Medical Research -- methods
KW - Doxorubicin -- administration & dosage
KW - Sulfonamides -- administration & dosage
KW - Cisplatin -- administration & dosage
KW - Biomarkers, Tumor -- metabolism
KW - Hydroxamic Acids -- administration & dosage
KW - Adult
KW - Middle Aged
KW - Maximum Tolerated Dose
KW - Female
KW - Male
KW - Neoplasms, Glandular and Epithelial -- drug therapy
KW - Neoplasms, Glandular and Epithelial -- metabolism
KW - Thymus Neoplasms -- metabolism
KW - Thymus Neoplasms -- drug therapy
KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+phase+I%2FII+trial+of+belinostat+in+combination+with+cisplatin%2C+doxorubicin%2C+and+cyclophosphamide+in+thymic+epithelial+tumors%3A+a+clinical+and+translational+study.&rft.au=Thomas%2C+Anish%3BRajan%2C+Arun%3BSzabo%2C+Eva%3BTomita%2C+Yusuke%3BCarter%2C+Corey+A%3BScepura%2C+Barbara%3BLopez-Chavez%2C+Ariel%3BLee%2C+Min-Jung%3BRedon%2C+Christophe+E%3BFrosch%2C+Ari%3BPeer%2C+Cody+J%3BChen%2C+Yuanbin%3BPiekarz%2C+Richard%3BSteinberg%2C+Seth+M%3BTrepel%2C+Jane+B%3BFigg%2C+William+D%3BSchrump%2C+David+S%3BGiaccone%2C+Giuseppe&rft.aulast=Thomas&rft.aufirst=Anish&rft.date=2014-11-01&rft.volume=20&rft.issue=21&rft.spage=5392&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-0968
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-01
N1 - Date created - 2014-11-01
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-0968
ER -
TY - JOUR
T1 - Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver.
AN - 1619317240; 25193995
AB - A lipidomic and metabolomic investigation of serum and liver from mice was performed to gain insight into the tumor suppressor gene Hint1. A major reprogramming of lipid homeostasis was found in both serum and liver of Hint1-null (Hint(-/-)) mice, with significant changes in the levels of many lipid molecules, as compared with gender-, age-, and strain-matched WT mice. In the Hint1(-/-) mice, serum total and esterified cholesterol were reduced 2.5-fold, and lysophosphatidylcholines (LPCs) and lysophosphatidic acids were 10-fold elevated in serum, with a corresponding fall in phosphatidylcholines (PCs). In the liver, MUFAs and PUFAs, including arachidonic acid (AA) and its metabolic precursors, were also raised, as was mRNA encoding enzymes involved in AA de novo synthesis. There was also a significant 50% increase in hepatic macrophages in the Hint1(-/-) mice. Several hepatic ceramides and acylcarnitines were decreased in the livers of Hint1(-/-) mice. The changes in serum LPCs and PCs were neither related to hepatic phospholipase A2 activity nor to mRNAs encoding lysophosphatidylcholine acetyltransferases 1-4. The lipidomic phenotype of the Hint1(-/-) mouse revealed decreased inflammatory eicosanoids with elevated proliferative mediators that, combined with decreased ceramide apoptosis signaling molecules, may contribute to the tumor suppressor activity of Hint1.
Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc.
JF - Journal of lipid research
AU - Beyoğlu, Diren
AU - Krausz, Kristopher W
AU - Martin, Juliette
AU - Maurhofer, Olivier
AU - Dorow, Juliane
AU - Ceglarek, Uta
AU - Gonzalez, Frank J
AU - Dufour, Jean-François
AU - Idle, Jeffrey R
AD - Hepatology Research Group, Department of Clinical Research, University of Bern, Switzerland. ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. ; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany. ; Hepatology Research Group, Department of Clinical Research, University of Bern, Switzerland Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 2309
EP - 2319
VL - 55
IS - 11
KW - Hint1 protein, mouse
KW - 0
KW - Lipids
KW - Nerve Tissue Proteins
KW - Index Medicus
KW - lipidomics
KW - proliferation
KW - phospholipids
KW - eicosanoids
KW - carcinogenesis
KW - mass spectrometry
KW - apoptosis
KW - cholesterol
KW - metabolomics
KW - Lipids -- blood
KW - Gene Knockout Techniques
KW - Animals
KW - Mice
KW - Male
KW - Phenotype
KW - Nerve Tissue Proteins -- deficiency
KW - Genes, Tumor Suppressor
KW - Liver -- metabolism
KW - Lipid Metabolism -- genetics
KW - Nerve Tissue Proteins -- genetics
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=Disruption+of+tumor+suppressor+gene+Hint1+leads+to+remodeling+of+the+lipid+metabolic+phenotype+of+mouse+liver.&rft.au=Beyo%C4%9Flu%2C+Diren%3BKrausz%2C+Kristopher+W%3BMartin%2C+Juliette%3BMaurhofer%2C+Olivier%3BDorow%2C+Juliane%3BCeglarek%2C+Uta%3BGonzalez%2C+Frank+J%3BDufour%2C+Jean-Fran%C3%A7ois%3BIdle%2C+Jeffrey+R&rft.aulast=Beyo%C4%9Flu&rft.aufirst=Diren&rft.date=2014-11-01&rft.volume=55&rft.issue=11&rft.spage=2309&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=1539-7262&rft_id=info:doi/10.1194%2Fjlr.M050682
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-10-15
N1 - Date created - 2014-10-30
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1194/jlr.M050682
ER -
TY - JOUR
T1 - Inhaled nitric oxide usage in preterm infants in the NICHD neonatal research network: inter-site variation and propensity evaluation
AN - 1618822747; 24901452
AB - The use of inhaled nitric oxide (iNO) in preterm infants remains controversial. In October 2010, a National Institutes of Health consensus development conference cautioned against use of iNO in preterm infants. This study aims (1) to determine the prevalence and variability in use of iNO in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NICHD NRN) before and after the consensus conference and (2) separately, to examine associations between iNO use and severe bronchopulmonary dysplasia (BPD) or death.
The NICHD NRN Generic Database collects data including iNO use on very preterm infants. A total of 13 centers contributed data across the time period 2008 to 2011. Infants exposed or not to iNO were compared using logistic regression, which included factors related to risk as well as their likelihood of being exposed to iNO.
A total of 4885 infants were assessed between 2008 and 2011; 128 (2.6%) received iNO before day 7, 140 (2.9%) between day 7 and 28, and 47 (1.0%) at >28 days. Center-specific iNO use during 2008 to 2010 ranged from 21.9 to 0.4%; 12 of 13 sites reduced usage and overall NRN iNO usage decreased from 4.6 to 1.6% (P<0.001) in 2011. The use of iNO started between day 7 and day 14 was more prevalent among younger infants with more severe courses in week 1 and associated with increased risk of severe BPD or death (odds ratio 2.24; 95% confidence interval 1.23 to 4.07).
The variability and total use of iNO decreased in 2011 compared with 2008 to 2010. iNO administration started at day 7 was associated with more severe outcomes compared with infants without iNO exposure.
JF - Journal of Perinatology
AU - Truog, W E
AU - Nelin, L D
AU - Das, A
AU - Kendrick, D E
AU - Bell, E F
AU - Carlo, W A
AU - Higgins, R D
AU - Laptook, A R
AU - Sanchez, P J
AU - Shankaran, S
AU - Stoll, B J
AU - Van Meurs, K P
AU - Walsh, M C
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 842
EP - 6
CY - New York
PB - Nature Publishing Group
VL - 34
IS - 11
SN - 07438346
KW - Medical Sciences--Pediatrics
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Perinatology&rft.atitle=Inhaled+nitric+oxide+usage+in+preterm+infants+in+the+NICHD+neonatal+research+network%3A+inter-site+variation+and+propensity+evaluation&rft.au=Truog%2C+W+E%3BNelin%2C+L+D%3BDas%2C+A%3BKendrick%2C+D+E%3BBell%2C+E+F%3BCarlo%2C+W+A%3BHiggins%2C+R+D%3BLaptook%2C+A+R%3BSanchez%2C+P+J%3BShankaran%2C+S%3BStoll%2C+B+J%3BVan+Meurs%2C+K+P%3BWalsh%2C+M+C&rft.aulast=Truog&rft.aufirst=W&rft.date=2014-11-01&rft.volume=34&rft.issue=11&rft.spage=842&rft.isbn=&rft.btitle=&rft.title=Journal+of+Perinatology&rft.issn=07438346&rft_id=info:doi/10.1038%2Fjp.2014.105
LA - English
DB - ProQuest Central
N1 - Copyright - Copyright Nature Publishing Group Nov 2014
N1 - Last updated - 2014-12-16
DO - http://dx.doi.org/10.1038/jp.2014.105
ER -
TY - JOUR
T1 - A phase I and pharmacokinetic study of oral perifosine with different loading schedules in patients with refractory neoplasms.
AN - 1618156931; 25183650
AB - To determine the maximum tolerated dose (MTD) of perifosine (NSC 639966), an alkylphospholipid modulator of signal transduction, using different oral loading and maintenance regimens in an effort to avoid gastrointestinal toxicity while seeking maximal sustained plasma concentrations.
Thirty-one patients with advanced neoplasms were treated with monthly cycles of perifosine loading doses of 300, 600, 900, 1,200 and 1,500 mg (dose levels 1 through 5, respectively) on days 1-2 depending on the actual dose of the initial cycle. For subsequent cycles, perifosine loading doses were reduced to 100, 200, 300, 400 and 1,000 mg at the respective corresponding dose levels. Daily perifosine "maintenance" doses of 50, 100, 150, 200 and 250 mg for levels 1 through 5, respectively, commenced on days 2 or 3 and continued for a total of 21 days. No treatment was given for days 22-27. The pharmacokinetics of perifosine with these schedules was characterized. Dose-limiting diarrhea developed at or above dose level 4. The MTD and recommended phase II dose was dose level 3B, with a loading dose of 900 mg on day 1 divided into two doses of 450 mg administered 6 h apart and a maintenance dose of 150 mg on day 2 through 21. On subsequent cycles, the loading dose was reduced to 300 mg. Non-gastrointestinal toxicities included three episodes of gout or gout-like syndromes observed at doses above the MTD. The median peak plasma concentration of perifosine achieved at the MTD was approximately 8.3 µg/mL. Four patients had stable disease ranging from 167 to 735 days.
Perifosine given according to a loading and maintenance schedule can safely sustain concentrations of drug, approaching concentrations achieved in preclinical models with evidence of anti-tumor effect.
JF - Cancer chemotherapy and pharmacology
AU - Figg, William D
AU - Monga, Manish
AU - Headlee, Donna
AU - Shah, Avni
AU - Chau, Cindy H
AU - Peer, Cody
AU - Messman, Richard
AU - Elsayed, Yusri A
AU - Murgo, Anthony J
AU - Melillo, Giovanni
AU - Ryan, Qin C
AU - Kalnitskiy, Mikhail
AU - Senderowicz, Adrian M
AU - Hollingshead, Melinda
AU - Arbuck, Susan G
AU - Sausville, Edward A
AD - Medical Oncology Branch, National Cancer Institute, Bldg 10/Room 5A01, 9000 Rockville Pike, Bethesda, MD, 20892, USA, figgw@helix.nih.gov.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 955
EP - 967
VL - 74
IS - 5
KW - Phosphorylcholine
KW - 107-73-3
KW - perifosine
KW - 2GWV496552
KW - Index Medicus
KW - Administration, Oral
KW - Young Adult
KW - Drug Administration Schedule
KW - Area Under Curve
KW - Dose-Response Relationship, Drug
KW - Humans
KW - Fatigue -- chemically induced
KW - Disease Progression
KW - Metabolic Clearance Rate
KW - Aged
KW - Diarrhea -- chemically induced
KW - Aged, 80 and over
KW - Adult
KW - Treatment Outcome
KW - Middle Aged
KW - Anorexia -- chemically induced
KW - Male
KW - Female
KW - Neoplasms -- drug therapy
KW - Neoplasms -- pathology
KW - Phosphorylcholine -- pharmacokinetics
KW - Phosphorylcholine -- analogs & derivatives
KW - Phosphorylcholine -- adverse effects
KW - Neoplasms -- metabolism
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=A+phase+I+and+pharmacokinetic+study+of+oral+perifosine+with+different+loading+schedules+in+patients+with+refractory+neoplasms.&rft.au=Figg%2C+William+D%3BMonga%2C+Manish%3BHeadlee%2C+Donna%3BShah%2C+Avni%3BChau%2C+Cindy+H%3BPeer%2C+Cody%3BMessman%2C+Richard%3BElsayed%2C+Yusri+A%3BMurgo%2C+Anthony+J%3BMelillo%2C+Giovanni%3BRyan%2C+Qin+C%3BKalnitskiy%2C+Mikhail%3BSenderowicz%2C+Adrian+M%3BHollingshead%2C+Melinda%3BArbuck%2C+Susan+G%3BSausville%2C+Edward+A&rft.aulast=Figg&rft.aufirst=William&rft.date=2014-11-01&rft.volume=74&rft.issue=5&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-014-2569-7
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-01-29
N1 - Date created - 2014-10-27
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1007/s00280-014-2569-7
ER -
TY - JOUR
T1 - Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.
AN - 1618153390; 24723460
AB - Liver eosinophilia has been associated with incidences of drug-induced liver injury (DILI) for more than 50 years, although its role in this disease has remained largely unknown. In this regard, it was recently shown that eosinophils played a pathogenic role in a mouse model of halothane-induced liver injury (HILI). However, the signaling events that drove hepatic expression of eosinophil-associated chemokines, eotaxins, eosinophil infiltration, and subsequent HILI were unclear. We now provide evidence implicating hepatic epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) and type 2 immunity, in particular, interleukin-4 (IL-4) production, in mediating hepatic eosinophilia and injury during HILI. TSLP was constitutively expressed by mouse hepatocytes and increased during HILI. Moreover, the severity of HILI was reduced in mice deficient in either the TSLP receptor (TSLPR) or IL-4 and was accompanied by decreases in serum levels of eotaxins and hepatic eosinophilia. Similarly, concanavalin A-induced liver injury, where type 2 cytokines and eosinophils play a significant role in its pathogenesis, was also reduced in TSLPR-deficient mice. Studies in vitro revealed that mouse and human hepatocytes produce TSLP and eotaxins in response to treatment with combinations of IL-4 and proinflammatory cytokines IL-1β and tumor necrosis factor alpha.
This report provides the first evidence implicating roles for hepatic TSLP signaling, type 2 immunity, and eosinophilia in mediating liver injury caused by a drug. © 2014 by the American Association for the Study of Liver Diseases. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
JF - Hepatology (Baltimore, Md.)
AU - Proctor, William R
AU - Chakraborty, Mala
AU - Fullerton, Aaron M
AU - Korrapati, Midhun C
AU - Ryan, Pauline M
AU - Semple, Kenrick
AU - Morrison, Jeffrey C
AU - Berkson, Julia D
AU - Chea, Lynette S
AU - Yang, Qian
AU - Li, Albert P
AU - Spolski, Rosanne
AU - West, Erin E
AU - Rochman, Yrina
AU - Leonard, Warren J
AU - Bourdi, Mohammed
AU - Pohl, Lance R
AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 1741
EP - 1752
VL - 60
IS - 5
KW - Anesthetics, Inhalation
KW - 0
KW - Cytokines
KW - thymic stromal lymphopoietin
KW - Concanavalin A
KW - 11028-71-0
KW - Interleukin-4
KW - 207137-56-2
KW - Halothane
KW - UQT9G45D1P
KW - Index Medicus
KW - Hepatitis, Animal -- metabolism
KW - Animals
KW - Hepatocytes -- secretion
KW - Humans
KW - Mice, Inbred BALB C
KW - Female
KW - Anesthetics, Inhalation -- adverse effects
KW - Interleukin-4 -- metabolism
KW - Chemical and Drug Induced Liver Injury -- etiology
KW - Cytokines -- secretion
KW - Halothane -- adverse effects
KW - Cytokines -- metabolism
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Thymic+stromal+lymphopoietin+and+interleukin-4+mediate+the+pathogenesis+of+halothane-induced+liver+injury+in+mice.&rft.au=Proctor%2C+William+R%3BChakraborty%2C+Mala%3BFullerton%2C+Aaron+M%3BKorrapati%2C+Midhun+C%3BRyan%2C+Pauline+M%3BSemple%2C+Kenrick%3BMorrison%2C+Jeffrey+C%3BBerkson%2C+Julia+D%3BChea%2C+Lynette+S%3BYang%2C+Qian%3BLi%2C+Albert+P%3BSpolski%2C+Rosanne%3BWest%2C+Erin+E%3BRochman%2C+Yrina%3BLeonard%2C+Warren+J%3BBourdi%2C+Mohammed%3BPohl%2C+Lance+R&rft.aulast=Proctor&rft.aufirst=William&rft.date=2014-11-01&rft.volume=60&rft.issue=5&rft.spage=1741&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.27169
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-12-30
N1 - Date created - 2014-10-27
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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Comment In:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1002/hep.27169
ER -
TY - JOUR
T1 - Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the garter snake Thamnophis sirtalis.
AN - 1618153170; 25135948
AB - Members of a gene family expressed in a single species often experience common selection pressures. Consequently, the molecular basis of complex adaptations may be expected to involve parallel evolutionary changes in multiple paralogs. Here, we use bacterial artificial chromosome library scans to investigate the evolution of the voltage-gated sodium channel (Nav) family in the garter snake Thamnophis sirtalis, a predator of highly toxic Taricha newts. Newts possess tetrodotoxin (TTX), which blocks Nav's, arresting action potentials in nerves and muscle. Some Thamnophis populations have evolved resistance to extremely high levels of TTX. Previous work has identified amino acid sites in the skeletal muscle sodium channel Nav1.4 that confer resistance to TTX and vary across populations. We identify parallel evolution of TTX resistance in two additional Nav paralogs, Nav1.6 and 1.7, which are known to be expressed in the peripheral nervous system and should thus be exposed to ingested TTX. Each paralog contains at least one TTX-resistant substitution identical to a substitution previously identified in Nav1.4. These sites are fixed across populations, suggesting that the resistant peripheral nerves antedate resistant muscle. In contrast, three sodium channels expressed solely in the central nervous system (Nav1.1-1.3) showed no evidence of TTX resistance, consistent with protection from toxins by the blood-brain barrier. We also report the exon-intron structure of six Nav paralogs, the first such analysis for snake genes. Our results demonstrate that the molecular basis of adaptation may be both repeatable across members of a gene family and predictable based on functional considerations.
© The Author 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
JF - Molecular biology and evolution
AU - McGlothlin, Joel W
AU - Chuckalovcak, John P
AU - Janes, Daniel E
AU - Edwards, Scott V
AU - Feldman, Chris R
AU - Brodie, Edmund D
AU - Pfrender, Michael E
AD - Department of Biological Sciences, Virginia Tech, Blacksburg, VA Department of Biology, University of Virginia joelmcg@vt.edu. ; Department of Biology, University of Virginia Bio-Rad Laboratories, Hercules, CA. ; Department of Organismic and Evolutionary Biology, Harvard University Division of Genetics and Developmental Biology, National Institutes of Health, Bethesda, MD. ; Department of Organismic and Evolutionary Biology, Harvard University. ; Department of Biology, University of Nevada, Reno. ; Department of Biology, Utah State University. ; Department of Biological Sciences and Environmental Change Initiative, University of Notre Dame.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 2836
EP - 2846
VL - 31
IS - 11
KW - DNA Transposable Elements
KW - 0
KW - Protein Isoforms
KW - Sodium Channel Blockers
KW - Voltage-Gated Sodium Channels
KW - Tetrodotoxin
KW - 4368-28-9
KW - Index Medicus
KW - molecular evolution
KW - coevolution
KW - toxins
KW - predator–prey interactions
KW - gene families
KW - adaptation
KW - Animals
KW - Salamandridae -- physiology
KW - Exons
KW - Protein Isoforms -- metabolism
KW - Amino Acid Sequence
KW - Chromosomes, Artificial, Bacterial
KW - Microsatellite Repeats
KW - Predatory Behavior
KW - Sequence Alignment
KW - Protein Isoforms -- chemistry
KW - Introns
KW - Molecular Sequence Data
KW - Adaptation, Physiological
KW - Protein Isoforms -- genetics
KW - Gene Library
KW - Voltage-Gated Sodium Channels -- genetics
KW - Sodium Channel Blockers -- metabolism
KW - Tetrodotoxin -- toxicity
KW - Sodium Channel Blockers -- toxicity
KW - Drug Resistance -- genetics
KW - Tetrodotoxin -- biosynthesis
KW - Biological Evolution
KW - Voltage-Gated Sodium Channels -- chemistry
KW - Voltage-Gated Sodium Channels -- metabolism
KW - Colubridae -- genetics
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-06-22
N1 - Date created - 2014-10-27
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/molbev/msu237
ER -
TY - JOUR
T1 - Gynecologic Cancer InterGroup (GCIG) consensus review for squamous cell carcinoma of the ovary.
AN - 1618151666; 25126954
AB - Squamous cell carcinoma of the ovary is a rare complication of mature cystic teratoma. The epidemiology, pathology, diagnosis, and management of this rare tumor are reviewed. Clinical characteristics, preoperative imaging, and tumor markers may help to predict malignancy preoperatively. Complete cytoreduction should be the aim of surgery. The prognosis for stage 1A disease is good, but for women with advanced or recurrent disease, it is very poor and has not improved in recent years. At present, there are insufficient data to provide clear guidance on the optimal management strategy for advanced disease, and there is a need to gain an understanding of the biology and to develop novel effective therapies. This will require coordinated international collaboration.
JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
AU - Glasspool, Rosalind M
AU - González Martín, Antonio
AU - Millan, David
AU - Lorusso, Domenica
AU - Åvall-Lundqvist, Elisabeth
AU - Hurteau, Jean A
AU - Davis, Alison
AU - Hilpert, Felix
AU - Kim, Jae-Weon
AU - Alexandre, Jérôme
AU - Ledermann, Jonathan A
AD - *Beatson West of Scotland Cancer Centre, Glasgow, UK (SGCTG); †Medical Oncology Department, MD Anderson Cancer Centre, Madrid, Spain (GEICO); ‡Southern General Hospital, Glasgow, UK (SGCTG); §Gynecologic Oncology Unit, Fondazione IRCCS National Cancer institute of Milan (MITO), Milan, Italy; ‖Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden (NSGO); ¶Division of Gynecologic Oncology, NorthShore University Health System, University of Chicago Pritzker School of Medicine, Evanston, IL (GOG); #The Canberra Hospital, Canberra, Australia (ANZGOG); **University Hospital of Schleswig-Holstein Campus, Kiel, Germany (AGO); ††Department of Obstectrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea (KGOG); ‡‡Medical Oncology, Cochin-Hôtel Dieu, Paris Descartes University, Paris, France (GINECO); and §§UCL Cancer Institute, London, UK (NCRI/MRC).
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - S26
EP - S29
VL - 24
IS - 9 Suppl 3
KW - Index Medicus
KW - Combined Modality Therapy
KW - Humans
KW - Consensus
KW - Societies, Medical
KW - Female
KW - Carcinoma, Squamous Cell -- pathology
KW - Ovarian Neoplasms -- pathology
KW - Practice Guidelines as Topic
KW - Medical Oncology
KW - Ovarian Neoplasms -- therapy
KW - Carcinoma, Squamous Cell -- therapy
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.atitle=Gynecologic+Cancer+InterGroup+%28GCIG%29+consensus+review+for+squamous+cell+carcinoma+of+the+ovary.&rft.au=Glasspool%2C+Rosalind+M%3BGonz%C3%A1lez+Mart%C3%ADn%2C+Antonio%3BMillan%2C+David%3BLorusso%2C+Domenica%3B%C3%85vall-Lundqvist%2C+Elisabeth%3BHurteau%2C+Jean+A%3BDavis%2C+Alison%3BHilpert%2C+Felix%3BKim%2C+Jae-Weon%3BAlexandre%2C+J%C3%A9r%C3%B4me%3BLedermann%2C+Jonathan+A&rft.aulast=Glasspool&rft.aufirst=Rosalind&rft.date=2014-11-01&rft.volume=24&rft.issue=9+Suppl+3&rft.spage=S26&rft.isbn=&rft.btitle=&rft.title=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.issn=1525-1438&rft_id=info:doi/10.1097%2FIGC.0000000000000209
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-07
N1 - Date created - 2014-10-24
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1097/IGC.0000000000000209
ER -
TY - JOUR
T1 - Association between treatment toxicity and outcomes in oncology clinical trials.
AN - 1616481934; 25193993
AB - Whether or not toxicity predicts clinical outcomes has long been a question regarding cancer treatments. While prior studies have focused on specific cancers, therapies, and toxicities, no comprehensive evidence exists on whether treatment toxicity predicts favorable outcomes.
We abstracted treatment toxicity and clinical outcome data from a sample of phase III oncology randomized clinical trials (n = 99 trials). We investigated whether treatments with relatively greater toxicity compared with their controls had relatively higher, lower, or equivocal rates of clinical efficacy, measured by progression-free survival (PFS) and overall survival (OS). Several toxicities were assessed (all grades, grades III/IV, cutaneous rash, gastrointestinal toxicity, and myelosuppression). Toxicity and efficacy were greater among treatments than controls (e.g. 3.5 instances of all-grade toxicity per patient in treatment arms versus 2.8 instances in controls, P < 0.001; mean PFS of 9.1 months across treatment arms versus 7.1 months across controls, P < 0.001; mean OS of 18.6 months across treatment arms versus 16.9 months across controls, P < 0.001). Across trials, greater relative treatment toxicity was strongly associated with greater PFS in treatments versus controls (P < 0.001), but not OS (P = 0.44). Although higher relative rates of myelosuppression and cutaneous rash among treatments were not associated with greater treatment efficacy, greater relative gastrointestinal toxicity among treatments was associated with greater relative PFS compared with controls (P = 0.007).
Across trials, treatments with relatively greater all-grade toxicity compared with controls are associated with relatively greater PFS but not OS. © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
JF - Annals of oncology : official journal of the European Society for Medical Oncology
AU - Abola, M V
AU - Prasad, V
AU - Jena, A B
AD - Department of Family Medicine, Case Western Reserve University School of Medicine, Cleveland. ; Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda. ; Department of Health Care Policy, Harvard Medical School, Boston Department of Medicine, Massachusetts General Hospital, Boston, USA jena@hcp.med.harvard.edu.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 2284
EP - 2289
VL - 25
IS - 11
KW - Antineoplastic Agents
KW - 0
KW - Index Medicus
KW - treatment toxicity
KW - clinical trials
KW - Randomized Controlled Trials as Topic
KW - Clinical Trials, Phase III as Topic
KW - Humans
KW - Treatment Outcome
KW - Neoplasms -- drug therapy
KW - Disease-Free Survival
KW - Neoplasms -- pathology
KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects
KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
KW - Antineoplastic Agents -- therapeutic use
KW - Antineoplastic Agents -- adverse effects
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-03
N1 - Date created - 2014-10-24
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/annonc/mdu444
ER -
TY - JOUR
T1 - Moving beyond rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone for diffuse large B-cell lymphoma.
AN - 1615745030; 24438195
AB - Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell non-Hodgkin lymphoma (NHL). While the de facto treatment standard R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) is curative in most cases, it is ineffective for a significant proportion of patients, particularly those with intermediate and high-risk disease. Efforts to improve upon the results of R-CHOP have principally explored dose intensification of chemotherapy and resulted in considerable additive toxicity without clear benefit. DLBCL is not a uniform disease, however, and can be dissected into distinct molecular subtypes by gene expression profiling. These subtypes are characterized by distinct oncogenic mechanisms of activation and addictions to aberrant intracellular signaling pathways. Novel therapeutic agents that target these pathway addictions are emerging, and may have specific activity within molecular subtypes of DLBCL. To move beyond R-CHOP for all patients with DLBCL, targeted therapies added to the most effective chemotherapy platforms must be studied within the context of molecularly defined subsets.
JF - Leukemia & lymphoma
AU - Roschewski, Mark
AU - Dunleavy, Kieron
AU - Wilson, Wyndham H
AD - Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD , USA.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 2428
EP - 2437
VL - 55
IS - 11
KW - Antibodies, Monoclonal, Murine-Derived
KW - 0
KW - Rituximab
KW - 4F4X42SYQ6
KW - Vincristine
KW - 5J49Q6B70F
KW - Doxorubicin
KW - 80168379AG
KW - Cyclophosphamide
KW - 8N3DW7272P
KW - Prednisone
KW - VB0R961HZT
KW - Index Medicus
KW - chemotherapeutic approaches
KW - Lymphoma and Hodgkin disease
KW - molecular genetics
KW - Cyclophosphamide -- administration & dosage
KW - Humans
KW - Antibodies, Monoclonal, Murine-Derived -- administration & dosage
KW - Vincristine -- administration & dosage
KW - Treatment Outcome
KW - Doxorubicin -- administration & dosage
KW - Prednisone -- administration & dosage
KW - Lymphoma, Large B-Cell, Diffuse -- drug therapy
KW - Molecular Targeted Therapy -- methods
KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
KW - Molecular Targeted Therapy -- trends
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Moving+beyond+rituximab%2C+cyclophosphamide%2C+doxorubicin%2C+vincristine+and+prednisone+for+diffuse+large+B-cell+lymphoma.&rft.au=Roschewski%2C+Mark%3BDunleavy%2C+Kieron%3BWilson%2C+Wyndham+H&rft.aulast=Roschewski&rft.aufirst=Mark&rft.date=2014-11-01&rft.volume=55&rft.issue=11&rft.spage=2428&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=1029-2403&rft_id=info:doi/10.3109%2F10428194.2014.883075
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-20
N1 - Date created - 2014-10-22
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.3109/10428194.2014.883075
ER -
TY - JOUR
T1 - Incidence of hospitalization in patients receiving short course palliative cranial radiotherapy on outpatient basis in a limited resource setting - Experience from a regional cancer center in India.
AN - 1615739090; 25337417
AB - To investigate incidence of toxicity and related hospitalization among patients treated at our institute by a short course of palliative cranial radiotherapy against a longer, widely established schedule.
Shorter schedule palliative cranial radiotherapy is more convenient for patients and reduce waiting times. Although many studies have established safety of short schedules, the need for hospitalization due to acute treatment toxicity remains under-explored. Hospital admissions are an economic burden both for the patient and healthcare system in a limited resource setting. Delivery of treatment on an outpatient basis and within shorter times is preferred by patients, caregivers and healthcare staff. This was a prospective study on 68 patients treated with palliative whole brain radiotherapy between November 2010 and October 2012. One group received 20 Gy in 5 fractions over 1 week and the other group, 30 Gy in 10 fractions over 2 weeks. Treatment toxicity due to cranial radiotherapy was assessed as per RTOG acute and late toxicity criteria. Need for hospitalization owing to acute toxicity was also noted. Significant differences in the study parameters between the two groups were calculated by Fisher's t-test.
Requirement for hospital stay due to acute toxicity was not significantly different between the two groups. Patients in both groups experienced similar toxicity both during and after treatment. The shorter course entailed no significant increase in toxicity related admissions, suitable for limited resource settings where patient transport is difficult, there are financial constraints, and the healthcare system is overburdened.
JF - Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
AU - Gangopadhyay, Aparna
AU - Das, Joydeep
AU - Nath, Partha
AU - Maji, Tapas
AU - Biswas, Jaydip
AD - Dept. of Radiation Oncology, Chittaranjan National Cancer Institute, Kolkata, India. ; Dept. of Medical Oncology, Chittaranjan National Cancer Institute, Kolkata, India.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 428
EP - 432
VL - 19
IS - 6
SN - 1507-1367, 1507-1367
KW - Palliative cranial radiation
KW - Radiation toxicity and patient care
KW - In-hospital care for brain metastases
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reports+of+practical+oncology+and+radiotherapy+%3A+journal+of+Greatpoland+Cancer+Center+in+Poznan+and+Polish+Society+of+Radiation+Oncology&rft.atitle=Incidence+of+hospitalization+in+patients+receiving+short+course+palliative+cranial+radiotherapy+on+outpatient+basis+in+a+limited+resource+setting+-+Experience+from+a+regional+cancer+center+in+India.&rft.au=Gangopadhyay%2C+Aparna%3BDas%2C+Joydeep%3BNath%2C+Partha%3BMaji%2C+Tapas%3BBiswas%2C+Jaydip&rft.aulast=Gangopadhyay&rft.aufirst=Aparna&rft.date=2014-11-01&rft.volume=19&rft.issue=6&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Reports+of+practical+oncology+and+radiotherapy+%3A+journal+of+Greatpoland+Cancer+Center+in+Poznan+and+Polish+Society+of+Radiation+Oncology&rft.issn=15071367&rft_id=info:doi/10.1016%2Fj.rpor.2014.04.006
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-10-22
N1 - Date created - 2014-10-22
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.rpor.2014.04.006
ER -
TY - JOUR
T1 - Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front-line therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin, megakaryocyte potentiating factor, and cancer antigen 125.
AN - 1615262375; 24989332
AB - The primary objective of this study was to determine the safety and maximum tolerated dose (MTD) of the antimesothelin immunotoxin SS1(dsFv)PE38 (SS1P) (a recombinant antimesothelin immunotoxin consisting of a murine antimesothelin variable antibody fragment [Fv] linked to PE38, a truncated portion of Pseudomonas exotoxin A) in combination with pemetrexed and cisplatin in chemotherapy-naive patients with advanced malignant pleural mesothelioma (MPM). Secondary objectives included tumor response, SS1P pharmacokinetics, and serum biomarkers of response. Chemotherapy-naive patients with stage III or IV, unresectable, epithelial or biphasic MPM and normal organ functions were eligible. Pemetrexed (500 mg/m(2) on day 1) and cisplatin (75 mg/m(2) on day 1) were administered every 3 weeks for up to 6 cycles with escalating doses of SS1P administered intravenously on days 1, 3, and 5 during cycles 1 and 2. Tumor response was evaluated every 6 weeks.
Twenty-four patients received SS1P at 4 dose levels from 25 to 55 mcg/kg. Grade 3 fatigue was dose-limiting in 1 patient at 55 mcg/kg. The MTD of SS1P was established as 45 mcg/kg. Other grade 3 toxicities associated with SS1P included hypoalbuminemia (21%), back pain (13%), and hypotension (8%). Of 20 evaluable patients, 12 (60%) had a partial response, 3 had stable disease, and 5 had progressive disease. Of 13 patients who received the MTD, 10 (77%) had a partial response, 1 had stable disease, and 2 had progressive disease. Objective radiologic responses were associated with significant decreases in serum mesothelin (P=.0030), megakaryocyte potentiating factor (P=.0005), and cancer antigen 125 (P < .0001).
SS1P given with pemetrexed and cisplatin is safe and well tolerated and exhibits significant antitumor activity in patients with unresectable, advanced pleural mesothelioma. Serum mesothelin, megakaryocyte potentiating factor, and cancer antigen 125 levels correlated with objective tumor responses. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
JF - Cancer
AU - Hassan, Raffit
AU - Sharon, Elad
AU - Thomas, Anish
AU - Zhang, Jingli
AU - Ling, Alexander
AU - Miettinen, Markku
AU - Kreitman, Robert J
AU - Steinberg, Seth M
AU - Hollevoet, Kevin
AU - Pastan, Ira
AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Y1 - 2014/11/01/
PY - 2014
DA - 2014 Nov 01
SP - 3311
EP - 3319
VL - 120
IS - 21
KW - Antibodies, Monoclonal
KW - 0
KW - Bacterial Toxins
KW - CA-125 Antigen
KW - Exotoxins
KW - GPI-Linked Proteins
KW - Glutamates
KW - SS1(dsFv)PE38
KW - Virulence Factors
KW - mesothelin
KW - Pemetrexed
KW - 04Q9AIZ7NO
KW - Guanine
KW - 5Z93L87A1R
KW - ADP Ribose Transferases
KW - EC 2.4.2.-
KW - toxA protein, Pseudomonas aeruginosa
KW - EC 2.4.2.31
KW - Cisplatin
KW - Q20Q21Q62J
KW - Abridged Index Medicus
KW - Index Medicus
KW - pleural mesothelioma
KW - SS1P
KW - immunotoxin
KW - Neoplasm Staging
KW - Humans
KW - Aged
KW - GPI-Linked Proteins -- administration & dosage
KW - Cisplatin -- administration & dosage
KW - CA-125 Antigen -- blood
KW - GPI-Linked Proteins -- blood
KW - Middle Aged
KW - Maximum Tolerated Dose
KW - Female
KW - Male
KW - Antibodies, Monoclonal -- blood
KW - Pleural Neoplasms -- blood
KW - Lung Neoplasms -- blood
KW - Lung Neoplasms -- drug therapy
KW - Pleural Neoplasms -- pathology
KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage
KW - Antibodies, Monoclonal -- administration & dosage
KW - Guanine -- administration & dosage
KW - Mesothelioma -- drug therapy
KW - Mesothelioma -- blood
KW - Glutamates -- administration & dosage
KW - Pleural Neoplasms -- drug therapy
KW - Mesothelioma -- pathology
KW - Guanine -- analogs & derivatives
KW - Lung Neoplasms -- pathology
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-03-13
N1 - Date created - 2014-10-21
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Comment In:
Cancer. 2014 Nov 1;120(21):3268-71 [24989696]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1002/cncr.28875
ER -
TY - JOUR
T1 - Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene.
AN - 1614694870; 25245543
AB - The polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene (BP) is thought to bind covalently to DNA, through metabolism by cytochrome P450 1A1 (CYP1A1) and CYP1B1, and other enzymes, to form r7, t8, t9-trihydroxy-c-10-(N(2)-deoxyguanosyl)-7,8,9,10-tetrahydro-benzo[a]-pyrene (BPdG). Evaluation of RNA expression data, to understand the contribution of different metabolic enzymes to BPdG formation, is typically presented as fold-change observed upon BP exposure, leaving the actual number of RNA transcripts unknown. Here, we have quantified RNA copies/ng cDNA (RNA cpn) for CYP1A1 and CYP1B1, as well as quinone oxidoreductase 1 (NQO1), which may reduce formation of BPdG adducts, using primary normal human mammary epithelial cell (NHMEC) strains, and the MCF-7 breast cancer cell line. In unexposed NHMECs, basal RNA cpn values were 58-836 for CYP1A1, 336-5587 for CYP1B1 and 5943-40112 for NQO1. In cells exposed to 4.0 µM BP for 12h, RNA cpn values were 251-13234 for CYP1A1, 4133-57078 for CYP1B1 and 4456-55887 for NQO1. There were 3.5 (mean, range 0.2-15.8) BPdG adducts/10(8) nucleotides in the NHMECs (n = 16), and 790 in the MCF-7s. In the NHMECs, BP-induced CYP1A1 RNA cpn was highly associated with BPdG (P = 0.002), but CYP1B1 and NQO1 were not. Western blots of four NHMEC strains, chosen for different levels of BPdG adducts, showed a linear correlation between BPdG and CYP1A1, but not CYP1B1 or NQO1. Ethoxyresorufin-O-deethylase (EROD) activity, which measures CYP1A1 and CYP1B1 together, correlated with BPdG, but NQO1 activity did not. Despite more numerous levels of CYP1B1 and NQO1 RNA cpn in unexposed and BP-exposed NHMECs and MCF-7cells, BPdG formation was only correlated with induction of CYP1A1 RNA cpn. The higher level of BPdG in MCF-7 cells, compared to NHMECs, may have been due to a much increased induction of CYP1A1 and EROD. Overall, BPdG correlation was observed with CYP1A1 protein and CYP1A1/1B1 enzyme activity, but not with CYP1B1 or NQO1 protein, or NQO1 enzyme activity.
Published by Oxford University Press on behalf of the UK Environmental Mutagen Society 2014.
JF - Mutagenesis
AU - Divi, Rao L
AU - Lindeman, Tracey L Einem
AU - Shockley, Marie E
AU - Keshava, Channa
AU - Weston, Ainsley
AU - Poirier, Miriam C
AD - Carcinogen-DNA Interactions Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20817, USA, National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA and Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA and. ; Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. ; Carcinogen-DNA Interactions Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20817, USA, National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA and Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. poirierm@exchange.nih.gov.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 409
EP - 417
VL - 29
IS - 6
KW - DNA Adducts
KW - 0
KW - RNA, Messenger
KW - Benzo(a)pyrene
KW - 3417WMA06D
KW - Cytochrome P-450 CYP1A1
KW - EC 1.14.14.1
KW - Cytochrome P-450 CYP1B1
KW - NAD(P)H Dehydrogenase (Quinone)
KW - EC 1.6.5.2
KW - NQO1 protein, human
KW - Index Medicus
KW - Blotting, Western
KW - RNA, Messenger -- metabolism
KW - Cytochrome P-450 CYP1B1 -- metabolism
KW - Humans
KW - MCF-7 Cells
KW - NAD(P)H Dehydrogenase (Quinone) -- metabolism
KW - RNA, Messenger -- genetics
KW - Epithelial Cells -- metabolism
KW - Mammary Glands, Human -- cytology
KW - Cytochrome P-450 CYP1A1 -- genetics
KW - Epithelial Cells -- drug effects
KW - Benzo(a)pyrene -- toxicity
KW - Cytochrome P-450 CYP1A1 -- metabolism
KW - DNA Adducts -- metabolism
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-06-18
N1 - Date created - 2014-10-20
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1093/mutage/geu049
ER -
TY - JOUR
T1 - Adolescent alcohol use: a reflection of national drinking patterns and policy?
AN - 1613949946; 4610454
AB - To analyse how adolescent drunkenness and frequency of drinking were associated with adult drinking patterns and alcohol control policies. Cross-sectional survey data on 13- and 15-year-olds in 37 countries who participated in the Health Behaviour in School-Aged Children (HBSC) Study in 2010 (n=144788) were linked to national-level indicators on alcohol control policies and adult drinking patterns. Outcome measures were self-reported weekly drinking and life-time drunkenness (drunk once or more). Data were analysed using multi-level logistic regression models. In the mutually adjusted models, adolescent drunkenness was associated significantly with high adult alcohol consumption [odds ratio (OR)=3.15 among boys, 95% confidence interval (CI)=2.13-4.64, OR girls=2.44, CI=1.57-3.80] and risky drinking patterns in the adult population (OR boys=2.02, CI=1.33-3.05, OR girls=1.61, CI=1.18-2.18). The level of abstainers in the adult population was also associated significantly with girls' drunkenness; a 10% increase in the number of abstainers in a country reduced the odds of drunkenness with 21% (OR=0.79, CI= 0.68-0.90). Weekly drinking was associated significantly with weak restrictions on availability (OR boys=2.82, CI=1.74-4.54, OR girls=2.00, CI=1.15-3.46) and advertising (OR boys=1.56, CI=1.02-2.40, OR girls=1.79, CI=1.10-2.94). Comparing data cross-nationally, high levels of adult alcohol consumption and limited alcohol control policies are associated with high levels of alcohol use among adolescents. Reprinted by permission of Blackwell Publishing
JF - Addiction
AU - Ter Bogt, Tom
AU - Holstein, Bjørn E
AU - Bendtsen, Pernille
AU - Damsgaard, Mogens Trab
AU - Huckle, Taisia
AU - Casswell, Sally
AU - Kuntsche, Emmanuel
AU - Arnold, Petra
AU - De Looze, Margreet E
AU - Hofmann, Felix
AU - Hublet, Anne
AU - Simons-Morton, Bruce
AD - University of Southern Denmark ; Massey University ; Swiss Institute for the Prevention of Alcohol and Drug Problems ; Radboud University Nijmegen ; Utrecht University ; Ludwig Boltzmann Institut ; Ghent University ; Eunice Kennedy Shriver National Institute of Child Health and Human Development
Y1 - 2014/11//
PY - 2014
DA - Nov 2014
SP - 1857
EP - 1868
VL - 109
IS - 11
SN - 0965-2140, 0965-2140
KW - Sociology
KW - Alcohol
KW - Adolescence
KW - Alcoholism
KW - Regression analysis
KW - Consumption
KW - Advertising
KW - Youth
KW - Adolescents
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1613949946?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Adolescent+alcohol+use%3A+a+reflection+of+national+drinking+patterns+and+policy%3F&rft.au=Ter+Bogt%2C+Tom%3BHolstein%2C+Bj%C3%B8rn+E%3BBendtsen%2C+Pernille%3BDamsgaard%2C+Mogens+Trab%3BHuckle%2C+Taisia%3BCasswell%2C+Sally%3BKuntsche%2C+Emmanuel%3BArnold%2C+Petra%3BDe+Looze%2C+Margreet+E%3BHofmann%2C+Felix%3BHublet%2C+Anne%3BSimons-Morton%2C+Bruce&rft.aulast=Ter+Bogt&rft.aufirst=Tom&rft.date=2014-11-01&rft.volume=109&rft.issue=11&rft.spage=1857&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.12681
LA - English
DB - International Bibliography of the Social Sciences (IBSS)
N1 - Date revised - 2014-10-20
N1 - Last updated - 2014-10-20
N1 - SubjectsTermNotLitGenreText - 590 652 5676 646 6091; 593; 13779 652 5676 646 6091; 909; 913 561 6220; 608 7738 11245 11239; 2805 3872 554 971; 10739 12228 10919
DO - http://dx.doi.org/10.1111/add.12681
ER -
TY - JOUR
T1 - DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
AN - 1613942424; 25190601
AB - Carcinogenesis is driven by the accumulation of mutations and abnormal DNA methylation patterns, particularly the hypermethylation of tumor‑suppressor genes. Changes in genomic DNA methylation patterns are established by the DNA methyltransferases (DNMTs) family: DNMT1, DNMT3a and DNMT3b. The DNMTs are known to be overexpressed in tumors. However, when the DNMTs expression profile is altered in earlier stages of carcinogenesis remains to be elucidated. The resistant hepatocyte model (RHM) allows the analysis of the hepatocellular carcinoma (HCC) from the formation of altered cell foci to the appearance of tumors in rats. To investigate the DNMTs expression in this model, we first observed that timp3, rassf1a and p16 genes became methylated during cancer development by methylation‑specific PCR (MSP) and the bisulphate sequencing PCR (BSP) of timp3. The differential expression at the RNA and protein level of the three DNMTs was also assessed. dnmt1 expression was higher in tumors than in normal and early cancer stages. However, no evident overexpression of the enzyme was identified by immunohistochemistry. By contrast, DNMT3a and DNMT3b were consistently subexpressed in tumors. In the present study, we report a carcinogenesis model that does not feature the overexpression of DNMT1 but exhibits a transient expression of DNMT3a and DNMT3b.
JF - Oncology reports
AU - Valencia Antúnez, Carlos Alberto
AU - Taja Chayeb, Lucía
AU - Rodríguez-Segura, Miguel Ángel
AU - López Álvarez, Guadalupe Soledad
AU - García-Cuéllar, Claudia M
AU - Villa Treviño, Saúl
AD - Department of Cell Biology Center for Research and Advanced Studies (CINVESTAV) IPN, Basic Research Branch, Mexico, D.F., Mexico. ; National Cancer Institute, Basic Research Branch, Mexico, D.F., Mexico. ; Department of Physics, Center for Research and Advanced Studies (CINVESTAV) IPN, Basic Research Branch, Mexico, D.F., Mexico.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 2093
EP - 2103
VL - 32
IS - 5
KW - Cyclin-Dependent Kinase Inhibitor p16
KW - 0
KW - RASSF1 protein, rat
KW - Tissue Inhibitor of Metalloproteinase-3
KW - Tumor Suppressor Proteins
KW - Diethylnitrosamine
KW - 3IQ78TTX1A
KW - 2-Acetylaminofluorene
KW - 9M98QLJ2DL
KW - DNA (Cytosine-5-)-Methyltransferase
KW - EC 2.1.1.37
KW - DNA methyltransferase 3A
KW - DNA methyltransferase 3B
KW - Index Medicus
KW - Rats
KW - Gene Expression Regulation, Neoplastic
KW - Animals
KW - DNA Methylation
KW - Tumor Suppressor Proteins -- genetics
KW - Tissue Inhibitor of Metalloproteinase-3 -- genetics
KW - Cyclin-Dependent Kinase Inhibitor p16 -- genetics
KW - Male
KW - DNA (Cytosine-5-)-Methyltransferase -- genetics
KW - Liver Neoplasms, Experimental -- pathology
KW - Liver Neoplasms, Experimental -- enzymology
KW - Liver Neoplasms, Experimental -- chemically induced
KW - DNA (Cytosine-5-)-Methyltransferase -- metabolism
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-10-26
N1 - Date created - 2014-10-17
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.3892/or.2014.3462
ER -
TY - JOUR
T1 - Raltegravir pharmacokinetics in neonates following maternal dosing.
AN - 1612290493; 25162819
AB - : International Maternal Pediatric Adolescent AIDS Clinical Trials P1097 was a multicenter trial to determine washout pharmacokinetics and safety of in utero/intrapartum exposure to raltegravir in infants born to HIV-infected pregnant women receiving raltegravir-based antiretroviral therapy. Twenty-two mother-infant pairs were enrolled; evaluable pharmacokinetic data were available from 19 mother-infant pairs. Raltegravir readily crossed the placenta, with a median cord blood/maternal delivery plasma raltegravir concentration ratio of 1.48 (range, 0.32-4.33). Raltegravir elimination was highly variable and extremely prolonged in some infants; [median t1/2 26.6 (range, 9.3-184) hours]. Prolonged raltegravir elimination likely reflects low neonatal UGT1A1 enzyme activity and enterohepatic recirculation. Excessive raltegravir concentrations must be avoided in the neonate because raltegravir at high plasma concentrations may increase the risk of bilirubin neurotoxicity. Subtherapeutic concentrations, which could lead to inadequate viral suppression and development of raltegravir resistance, must also be avoided. Two ongoing International Maternal Pediatric Adolescent AIDS Clinical Trials studies are further investigating the pharmacology of raltegravir in neonates.
JF - Journal of acquired immune deficiency syndromes (1999)
AU - Clarke, Diana F
AU - Acosta, Edward P
AU - Rizk, Matthew L
AU - Bryson, Yvonne J
AU - Spector, Stephen A
AU - Mofenson, Lynne M
AU - Handelsman, Edward
AU - Teppler, Hedy
AU - Welebob, Carolee
AU - Persaud, Deborah
AU - Cababasay, Mae P
AU - Wang, JiaJia
AU - Mirochnick, Mark
AU - International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1097 Study Team
AD - *Section of Pediatric Infectious Diseases, Boston Medical Center, Boston, MA; †Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, AL; ‡Merck & Co., Inc., Whitehouse Station, NJ; §Department of Pediatric Infectious Diseases, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA; ‖Department of Pediatrics, University of California, San Diego and Rady Children's Hospital San Diego, La Jolla, CA; ¶Eunice Kennedy Shriver National Institute of Child Health and Human Development, #Division of AIDS, National Institute of Health, Bethesda, MD; **Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD; ††Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA; and ‡‡Department of Pediatrics, Boston University School of Medicine, Boston, MA. ; International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1097 Study Team
Y1 - 2014/11/01/
PY - 2014
DA - 2014 Nov 01
SP - 310
EP - 315
VL - 67
IS - 3
KW - Anti-HIV Agents
KW - 0
KW - Pyrrolidinones
KW - Raltegravir Potassium
KW - 43Y000U234
KW - Index Medicus
KW - AIDS/HIV
KW - Humans
KW - Adult
KW - Infant, Newborn
KW - Male
KW - Female
KW - Pregnancy
KW - Anti-HIV Agents -- pharmacokinetics
KW - HIV Infections -- drug therapy
KW - Pregnancy Complications, Infectious -- metabolism
KW - HIV Infections -- metabolism
KW - Anti-HIV Agents -- administration & dosage
KW - Pyrrolidinones -- pharmacokinetics
KW - Pregnancy Complications, Infectious -- drug therapy
KW - Pyrrolidinones -- administration & dosage
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-12-15
N1 - Date created - 2014-10-14
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
J Perinatol. 2001 Dec;21 Suppl 1:S40-2; discussion S59-62 [11803415]
Toxicology. 2002 Dec 27;181-182:453-6 [12505351]
Pediatrics. 2004 Jul;114(1):297-316 [15231951]
Biochem J. 1979 Dec 15;184(3):705-7 [120201]
Pediatrics. 1956 Oct;18(4):614-25 [13370229]
Clin Pharmacol Ther. 2008 Feb;83(2):293-9 [17713476]
Antimicrob Agents Chemother. 2013 Dec;57(12):6393-4 [24080650]
Expert Opin Drug Metab Toxicol. 2010 Sep;6(9):1151-60 [20701552]
AIDS. 2010 Sep 24;24(15):2416-8 [20827058]
N Engl J Med. 2012 Jun 21;366(25):2368-79 [22716975]
AIDS. 2012 Nov 28;26(18):2421-3 [23151500]
Pediatr Infect Dis J. 2013 Sep;32(9):978-80 [23470680]
N Engl J Med. 2013 Nov 7;369(19):1828-35 [24152233]
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 15;867(2):165-71 [18430616]
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1097/QAI.0000000000000316
ER -
TY - JOUR
T1 - Activity of the EGFR-HER2 dual inhibitor afatinib in EGFR-mutant lung cancer patients with acquired resistance to reversible EGFR tyrosine kinase inhibitors.
AN - 1611618184; 25242668
AB - The purpose of this study was to evaluate the efficacy of afatinib in EGFR-mutant metastatic NSCLC patients with acquired resistance to erlotinib or gefitinib.
We retrospectively analyzed the outcome of patients with EGFR-mutant advanced NSCLC treated with afatinib after failure of chemotherapy and EGFR TKIs. A total of 96 individuals were included in the study. According to EGFR status, most patients (n = 63; 65.6%) harbored a deletion in exon 19, and de novo T790M mutation was detected in 2 cases (T790M and exon 19). Twenty-four (25%) patients underwent repeated biopsy immediately before starting afatinib and secondary T790M was detected in 8 (33%) samples. Among the 86 patients evaluable for efficacy, response rate was 11.6%, with a median progression free-survival (PFS) and overall survival (OS) of 3.9 and 7.3 months, respectively. No significant difference in PFS and OS was observed according to type of last therapy received before afatinib, type of EGFR mutation or adherence to Jackman criteria, and patients benefiting from afatinib therapy had longer PFS and OS (P < .001). Outcome results for repeated biopsy patients were similar to the whole population, with no evidence of response in T790M-positive patients. All patients were evaluable for toxicity, and 81% experienced an AE of any grade, with grade 3 to 4 AEs, mainly diarrhea and skin toxicity, occurring in 19 (20%) patients.
Our results showed that afatinib has only modest efficacy in a real life population of EGFR mutant NSCLC patients with acquired resistance to erlotinib or gefitinib. Copyright © 2014 Elsevier Inc. All rights reserved.
JF - Clinical lung cancer
AU - Landi, Lorenza
AU - Tiseo, Marcello
AU - Chiari, Rita
AU - Ricciardi, Serena
AU - Rossi, Elisa
AU - Galetta, Domenico
AU - Novello, Silvia
AU - Milella, Michele
AU - D'Incecco, Armida
AU - Minuti, Gabriele
AU - Tibaldi, Carmelo
AU - Salvini, Jessica
AU - Facchinetti, Francesco
AU - Haspinger, Eva Regina
AU - Cortinovis, Diego
AU - Santo, Antonio
AU - Banna, Giuseppe
AU - Catino, Annamaria
AU - GiajLevra, Matteo
AU - Crinò, Lucio
AU - de Marinis, Filippo
AU - Cappuzzo, Federico
AD - Department of MedicalOncology, Istituto Toscano Tumori, Livorno, Italy. ; Medical Oncology Unit, University Hospital of Parma, Parma, Italy. ; Division of Medical Oncology, Ospedale Santa Maria della Misericordia, Perugia, Italy. ; High Specialization Hospitals, Oncological Pulmonary First Unit, Rome, Italy. ; Fondazione Ricerca Traslazionale, FoRT, Rome, Italy. ; Division Of Medical Oncology, Istituto Tumori "Giovanni Paolo II", IRCCS, Bari, Italy. ; Department of Oncology, University of Turin, Azienda Ospedaliero-Universitaria, San Luigi Gonzaga, Turin, Italy. ; Division of Medical Oncology A, Regina Elena National Cancer Institute, Rome, Italy. ; Division of Medical Oncology, Fondazione IRCSS Istituto Nazionale dei Tumori, Milan, Italy. ; Division of Medical Oncology, Ospedale San Gerardo, Monza, Italy. ; Division of Medical Oncology, Azienda Ospedaliera Universitaria Integrate, Verona, Italy. ; Medical Oncology Service, Cannizzaro Hospital, Catania, Italy. ; Division of Thoracic Oncology, Istituto Europeo di Oncologia, Milano, Italy. ; Department of MedicalOncology, Istituto Toscano Tumori, Livorno, Italy. Electronic address: f.cappuzzo@gmail.com.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 411
EP - 417.e4
VL - 15
IS - 6
KW - Antineoplastic Agents
KW - 0
KW - Protein Kinase Inhibitors
KW - Quinazolines
KW - afatinib
KW - 41UD74L59M
KW - EGFR protein, human
KW - EC 2.7.10.1
KW - ERBB2 protein, human
KW - Receptor, Epidermal Growth Factor
KW - Receptor, ErbB-2
KW - Index Medicus
KW - Erlotinib
KW - Afatinib
KW - NSCLC
KW - Gefitinib
KW - Acquired resistance
KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors
KW - Disease-Free Survival
KW - Neoplasm Staging
KW - Receptor, ErbB-2 -- antagonists & inhibitors
KW - Humans
KW - Retrospective Studies
KW - Aged
KW - Receptor, Epidermal Growth Factor -- genetics
KW - Aged, 80 and over
KW - Adult
KW - Treatment Outcome
KW - Neoplasm Metastasis
KW - Mutation -- genetics
KW - Middle Aged
KW - Diarrhea -- etiology
KW - Female
KW - Male
KW - Quinazolines -- administration & dosage
KW - Protein Kinase Inhibitors -- therapeutic use
KW - Protein Kinase Inhibitors -- pharmacology
KW - Carcinoma, Non-Small-Cell Lung -- mortality
KW - Antineoplastic Agents -- administration & dosage
KW - Lung Neoplasms -- drug therapy
KW - Lung Neoplasms -- mortality
KW - Drug Resistance, Neoplasm
KW - Quinazolines -- adverse effects
KW - Carcinoma, Non-Small-Cell Lung -- drug therapy
KW - Lung Neoplasms -- pathology
KW - Carcinoma, Non-Small-Cell Lung -- pathology
KW - Antineoplastic Agents -- adverse effects
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-06-19
N1 - Date created - 2014-10-13
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.cllc.2014.07.002
ER -
TY - JOUR
T1 - Oesophageal squamous cell carcinoma in high-risk Chinese populations: Possible role for vascular epithelial growth factor A.
AN - 1610760353; 25172294
AB - Mechanisms involved in wound healing play some role in carcinogenesis in multiple organs, likely by creating a chronic inflammatory milieu. This study sought to assess the role of genetic markers in selected inflammation-related genes involved in wound healing (interleukin (IL)-1a, IL-1b, IL-1 Receptor type I (IL-1Ra), IL-1 Receptor type II (IL-1Rb), tumour necrosis factor (TNF)-α, tumour necrosis factor receptor superfamily member (TNFRSF)1A, nuclear factor kappa beta (NF-kB)1, NF-kB2, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, hypoxia induced factor (HIF)-1α, vascular endothelial growth factor (VEGF)A and P-53) in risk to oesophageal squamous cell carcinoma (OSCC).
We genotyped 125 tag single nucleotide polymorphism (SNP)s in 410 cases and 377 age and sex matched disease-free individuals from Nutritional Intervention Trial (NIT) cohort, and 546 cases and 556 controls individually matched for age, sex and neighbourhood from Shanxi case-control study, both conducted in high-risk areas of north-central China (1985-2007). Cox proportional-hazard models and conditional logistic regression models were used for SNPs analyses for NIT and Shanxi, respectively. Fisher's inverse test statistics were used to obtain gene-level significance. Multiple SNPs were significantly associated with OSCC in both studies, however, none retained their significance after a conservative Bonferroni adjustment. Empiric p-values for tag SNPs in VEGFA in NIT were highly concentrated in the lower tail of the distribution, suggesting this gene may be influencing risk. Permutation tests confirmed the significance of this pattern. At the gene level, VEGFA yielded an empiric significance (P=0.027) in NIT. We also observed some evidence for interaction between environmental factors and some VEGFA tag SNPs.
Our finding adds further evidence for a potential role for markers in the VEGFA gene in the development and progression of early precancerous lesions of oesophagus. Copyright © 2014 Elsevier Ltd. All rights reserved.
JF - European journal of cancer (Oxford, England : 1990)
AU - Golozar, Asieh
AU - Beaty, Terri H
AU - Gravitt, Patti E
AU - Ruczinski, Ingo
AU - Qiao, You-Lin
AU - Fan, Jin-Hu
AU - Ding, Ti
AU - Tang, Ze-Zhong
AU - Etemadi, Arash
AU - Hu, Nan
AU - Hyland, Paula L
AU - Wang, Lemin
AU - Wang, Chaoyu
AU - Dawsey, Sanford M
AU - Freedman, Neal D
AU - Abnet, Christian C
AU - Goldstein, Alisa M
AU - Taylor, Philip R
AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: agolozar@jhu.edu. ; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ; Department of Epidemiology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People's Republic of China. ; Shanxi Cancer Hospital, Taiyuan, Shanxi, People's Republic of China. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 2855
EP - 2865
VL - 50
IS - 16
KW - VEGFA protein, human
KW - 0
KW - Vascular Endothelial Growth Factor A
KW - Index Medicus
KW - Genetics
KW - Genetic marker
KW - Wound-healing
KW - Vascular endothelial growth factor A
KW - VEGFA
KW - Inflammation-related events
KW - Oesophageal squamous cell carcinoma
KW - Inflammation
KW - Esophagus -- metabolism
KW - Reproducibility of Results
KW - Humans
KW - Aged
KW - Gene Expression Regulation, Neoplastic
KW - Genotype
KW - Cohort Studies
KW - Case-Control Studies
KW - Middle Aged
KW - Quality Control
KW - China
KW - Female
KW - Male
KW - Proportional Hazards Models
KW - Polymorphism, Single Nucleotide
KW - Carcinoma, Squamous Cell -- epidemiology
KW - Esophageal Neoplasms -- metabolism
KW - Carcinoma, Squamous Cell -- metabolism
KW - Vascular Endothelial Growth Factor A -- metabolism
KW - Esophageal Neoplasms -- epidemiology
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.atitle=Oesophageal+squamous+cell+carcinoma+in+high-risk+Chinese+populations%3A+Possible+role+for+vascular+epithelial+growth+factor+A.&rft.au=Golozar%2C+Asieh%3BBeaty%2C+Terri+H%3BGravitt%2C+Patti+E%3BRuczinski%2C+Ingo%3BQiao%2C+You-Lin%3BFan%2C+Jin-Hu%3BDing%2C+Ti%3BTang%2C+Ze-Zhong%3BEtemadi%2C+Arash%3BHu%2C+Nan%3BHyland%2C+Paula+L%3BWang%2C+Lemin%3BWang%2C+Chaoyu%3BDawsey%2C+Sanford+M%3BFreedman%2C+Neal+D%3BAbnet%2C+Christian+C%3BGoldstein%2C+Alisa+M%3BTaylor%2C+Philip+R&rft.aulast=Golozar&rft.aufirst=Asieh&rft.date=2014-11-01&rft.volume=50&rft.issue=16&rft.spage=2855&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.issn=1879-0852&rft_id=info:doi/10.1016%2Fj.ejca.2014.07.022
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-12-08
N1 - Date created - 2014-10-10
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
J Natl Cancer Inst. 1993 Sep 15;85(18):1492-8 [8360932]
J Natl Cancer Inst. 1993 Sep 15;85(18):1483-92 [8360931]
Circulation. 1996 Apr 15;93(8):1493-5 [8608615]
Cancer. 1997 Jan 15;79(2):206-13 [9010092]
Cancer Res. 1999 Jan 1;59(1):198-204 [9892207]
J Biol Chem. 1999 Apr 16;274(16):10911-5 [10196169]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.ejca.2014.07.022
ER -
TY - JOUR
T1 - DAP1, a negative regulator of autophagy, controls SubAB-mediated apoptosis and autophagy.
AN - 1609505449; 25183729
AB - Autophagy and apoptosis play critical roles in cellular homeostasis and survival. Subtilase cytotoxin (SubAB), produced by non-O157 type Shiga-toxigenic Escherichia coli (STEC), is an important virulence factor in disease. SubAB, a protease, cleaves a specific site on the endoplasmic reticulum (ER) chaperone protein BiP/GRP78, leading to ER stress, and induces apoptosis. Here we report that in HeLa cells, activation of a PERK (RNA-dependent protein kinase [PKR]-like ER kinase)-eIF2α (α subunit of eukaryotic initiation factor 2)-dependent pathway by SubAB-mediated BiP cleavage negatively regulates autophagy and induces apoptosis through death-associated protein 1 (DAP1). We found that SubAB treatment decreased the amounts of autophagy markers LC3-II and p62 as well as those of mTOR (mammalian target of rapamycin) signaling proteins ULK1 and S6K. These proteins showed increased expression levels in PERK knockdown or DAP1 knockdown cells. In addition, depletion of DAP1 in HeLa cells dramatically inhibited the SubAB-stimulated apoptotic pathway: SubAB-induced Bax/Bak conformational changes, Bax/Bak oligomerization, cytochrome c release, activation of caspases, and poly(ADP-ribose) polymerase (PARP) cleavage. These results show that DAP1 is a key regulator, through PERK-eIF2α-dependent pathways, of the induction of apoptosis and reduction of autophagy by SubAB. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
JF - Infection and immunity
AU - Yahiro, Kinnosuke
AU - Tsutsuki, Hiroyasu
AU - Ogura, Kohei
AU - Nagasawa, Sayaka
AU - Moss, Joel
AU - Noda, Masatoshi
AD - Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan yahirok@faculty.chiba-u.jp. ; Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan. ; Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan Department of Legal Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan. ; Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 4899
EP - 4908
VL - 82
IS - 11
KW - Apoptosis Regulatory Proteins
KW - 0
KW - BAK1 protein, human
KW - BAX protein, human
KW - DAP protein, human
KW - Escherichia coli Proteins
KW - bcl-2 Homologous Antagonist-Killer Protein
KW - bcl-2-Associated X Protein
KW - Subtilisins
KW - EC 3.4.21.-
KW - subtilase cytotoxin, E coli
KW - Index Medicus
KW - bcl-2-Associated X Protein -- genetics
KW - bcl-2 Homologous Antagonist-Killer Protein -- genetics
KW - HeLa Cells
KW - Humans
KW - Escherichia coli
KW - bcl-2-Associated X Protein -- metabolism
KW - bcl-2 Homologous Antagonist-Killer Protein -- metabolism
KW - Escherichia coli Proteins -- metabolism
KW - Apoptosis Regulatory Proteins -- genetics
KW - Subtilisins -- genetics
KW - Gene Expression Regulation -- immunology
KW - Apoptosis -- physiology
KW - Apoptosis Regulatory Proteins -- metabolism
KW - Autophagy -- physiology
KW - Subtilisins -- metabolism
KW - Escherichia coli Proteins -- genetics
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=DAP1%2C+a+negative+regulator+of+autophagy%2C+controls+SubAB-mediated+apoptosis+and+autophagy.&rft.au=Yahiro%2C+Kinnosuke%3BTsutsuki%2C+Hiroyasu%3BOgura%2C+Kohei%3BNagasawa%2C+Sayaka%3BMoss%2C+Joel%3BNoda%2C+Masatoshi&rft.aulast=Yahiro&rft.aufirst=Kinnosuke&rft.date=2014-11-01&rft.volume=82&rft.issue=11&rft.spage=4899&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=1098-5522&rft_id=info:doi/10.1128%2FIAI.02213-14
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-12-15
N1 - Date created - 2014-10-08
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1128/IAI.02213-14
ER -
TY - JOUR
T1 - Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet.
AN - 1609101863; 25178843
AB - Methionine- and choline-deficient diet (MCD) is a model for nonalcoholic steatohepatitis (NASH) in rodents. However, the mechanism of NASH development by dietary methionine/choline deficiency remains undetermined. To elucidate the early metabolic changes associated with MCD-NASH, serum metabolomic analysis was performed using mice treated with MCD and control diet for 3 days and 1 week, revealing significant increases in oleic and linoleic acids after MCD treatment. These increases were correlated with reduced body weight and white adipose tissue (WAT) mass, increased phosphorylation of hormone-sensitive lipase, and up-regulation of genes encoding carboxylesterase 3 and β2-adrenergic receptor in WAT, indicating accelerated lipolysis in adipocytes. The changes in serum fatty acids and WAT by MCD treatment were reversed by methionine supplementation, and similar alterations were detected in mice fed a methionine-deficient diet (MD), thus demonstrating that dietary methionine deficiency enhances lipolysis in WAT. MD treatment decreased glucose and increased fibroblast growth factor 21 in serum, thus exhibiting a similar metabolic phenotype as the fasting response. Comparison between MCD and choline-deficient diet (CD) treatments suggested that the addition of MD-induced metabolic alterations, such as WAT lipolysis, to CD-induced hepatic steatosis promotes liver injury. Collectively, these results demonstrate an important role for dietary methionine deficiency and WAT lipolysis in the development of MCD-NASH.
Published by Elsevier B.V.
JF - Biochimica et biophysica acta
AU - Tanaka, Naoki
AU - Takahashi, Shogo
AU - Fang, Zhong-Ze
AU - Matsubara, Tsutomu
AU - Krausz, Kristopher W
AU - Qu, Aijuan
AU - Gonzalez, Frank J
AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Department of Toxicology, School of Public Health, Tianjin Medical University, Tianjin, China. ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Department of Anatomy and Regenerative Biology, Osaka City University, Osaka, Japan. ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: gonzalef@mail.nih.gov.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 1596
EP - 1607
VL - 1841
IS - 11
SN - 0006-3002, 0006-3002
KW - Index Medicus
KW - Fasting response
KW - Choline deficiency
KW - Lipolysis
KW - Oleic acid
KW - Metabolomics
KW - Linoleic acid
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1609101863?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Role+of+white+adipose+lipolysis+in+the+development+of+NASH+induced+by+methionine-+and+choline-deficient+diet.&rft.au=Tanaka%2C+Naoki%3BTakahashi%2C+Shogo%3BFang%2C+Zhong-Ze%3BMatsubara%2C+Tsutomu%3BKrausz%2C+Kristopher+W%3BQu%2C+Aijuan%3BGonzalez%2C+Frank+J&rft.aulast=Tanaka&rft.aufirst=Naoki&rft.date=2014-11-01&rft.volume=1841&rft.issue=11&rft.spage=1596&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbalip.2014.08.015
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date created - 2014-10-06
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
Hepatology. 2010 Aug;52(2):774-88 [20683968]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.bbalip.2014.08.015
ER -
TY - JOUR
T1 - Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism.
AN - 1609099054; 25107591
AB - Salvinorin A (SalA), a selective κ-opioid receptor (KOR) agonist, produces dysphoria and pro-depressant like effects. These actions have been attributed to inhibition of striatal dopamine release. The dopamine transporter (DAT) regulates dopamine transmission via uptake of released neurotransmitter. KORs are apposed to DAT in dopamine nerve terminals suggesting an additional target by which SalA modulates dopamine transmission. SalA produced a concentration-dependent, nor-binaltorphimine (BNI)- and pertussis toxin-sensitive increase of ASP(+) accumulation in EM4 cells coexpressing myc-KOR and YFP-DAT, using live cell imaging and the fluorescent monoamine transporter substrate, trans 4-(4-(dimethylamino)-styryl)-N-methylpyridinium) (ASP(+)). Other KOR agonists also increased DAT activity that was abolished by BNI pretreatment. While SalA increased DAT activity, SalA treatment decreased serotonin transporter (SERT) activity and had no effect on norepinephrine transporter (NET) activity. In striatum, SalA increased the Vmax for DAT mediated DA transport and DAT surface expression. SalA up-regulation of DAT function is mediated by KOR activation and the KOR-linked extracellular signal regulated kinase-½ (ERK1/2) pathway. Co-immunoprecipitation and BRET studies revealed that DAT and KOR exist in a complex. In live cells, DAT and KOR exhibited robust FRET signals under basal conditions. SalA exposure caused a rapid and significant increase of the FRET signal. This suggests that the formation of KOR and DAT complexes is promoted in response to KOR activation. Together, these data suggest that enhanced DA transport and decreased DA release resulting in decreased dopamine signalling may contribute to the dysphoric and pro-depressant like effects of SalA and other KOR agonists. Copyright © 2014 Elsevier Ltd. All rights reserved.
JF - Neuropharmacology
AU - Kivell, Bronwyn
AU - Uzelac, Zeljko
AU - Sundaramurthy, Santhanalakshmi
AU - Rajamanickam, Jeyaganesh
AU - Ewald, Amy
AU - Chefer, Vladimir
AU - Jaligam, Vanaja
AU - Bolan, Elizabeth
AU - Simonson, Bridget
AU - Annamalai, Balasubramaniam
AU - Mannangatti, Padmanabhan
AU - Prisinzano, Thomas E
AU - Gomes, Ivone
AU - Devi, Lakshmi A
AU - Jayanthi, Lankupalle D
AU - Sitte, Harald H
AU - Ramamoorthy, Sammanda
AU - Shippenberg, Toni S
AD - School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand; Integrative Neuroscience Section, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA. ; Medical University Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Waehringerstrasse 13a, A-1090 Vienna, Austria. ; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA. ; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand. ; Integrative Neuroscience Section, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA. ; Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA. ; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA. ; Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA. ; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address: sramamoorthy@vcu.edu.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 228
EP - 240
VL - 86
KW - Diterpenes, Clerodane
KW - 0
KW - Dopamine Agents
KW - Dopamine Plasma Membrane Transport Proteins
KW - Norepinephrine Plasma Membrane Transport Proteins
KW - Receptors, Opioid, kappa
KW - SLC6A2 protein, human
KW - SLC6A4 protein, human
KW - Serotonin Plasma Membrane Transport Proteins
KW - p38 Mitogen-Activated Protein Kinases
KW - EC 2.7.11.24
KW - salvinorin A
KW - T56W91NG6J
KW - Dopamine
KW - VTD58H1Z2X
KW - Index Medicus
KW - Dopamine transporter
KW - Serotonin transporter
KW - Kappa opioid receptor
KW - Dysphoric
KW - Pro-depressant
KW - Trafficking
KW - Salvinorin A
KW - Serotonin Plasma Membrane Transport Proteins -- metabolism
KW - Cell Membrane -- drug effects
KW - Humans
KW - HEK293 Cells
KW - Corpus Striatum -- metabolism
KW - Norepinephrine Plasma Membrane Transport Proteins -- metabolism
KW - Dopamine -- metabolism
KW - Corpus Striatum -- drug effects
KW - Cell Membrane -- metabolism
KW - p38 Mitogen-Activated Protein Kinases -- metabolism
KW - MAP Kinase Signaling System -- drug effects
KW - MAP Kinase Signaling System -- physiology
KW - Receptors, Opioid, kappa -- agonists
KW - Dopamine Agents -- pharmacology
KW - Receptors, Opioid, kappa -- metabolism
KW - Dopamine Plasma Membrane Transport Proteins -- metabolism
KW - Diterpenes, Clerodane -- pharmacology
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-07-14
N1 - Date created - 2014-10-06
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.neuropharm.2014.07.016
ER -
TY - JOUR
T1 - Quantitative determination of mithramycin in human plasma by a novel, sensitive ultra-HPLC-MS/MS method for clinical pharmacokinetic application.
AN - 1609098943; 25247492
AB - Mithramycin is a neoplastic antibiotic synthesized by various Streptomyces bacteria. It is under investigation as a chemotherapeutic treatment for a wide variety of cancers. Ongoing and forthcoming clinical trials will require pharmacokinetic analysis of mithramycin in humans, both to see if target concentrations are achieved and to optimize dosing and correlate outcomes (response/toxicity) with pharmacokinetics. Two published methods for mithramycin quantitation exist, but both are immunoassays that lack current bioanalytical standards of selectivity and sensitivity. To provide an upgraded and more widely applicable assay, a UPLC-MS/MS method for quantitation of mithramycin in human plasma was developed. Solid-phase extraction allowed for excellent recoveries (>90%) necessary for high throughput analyses on sensitive instrumentation. However, a ∼55% reduction in analyte signal was observed as a result of plasma matrix effects. Mithramycin and the internal standard chromomycin were separated on a Waters Acquity BEH C18 column (2.1×50 mm, 1.7 μm) and detected using electrospray ionization operated in the negative mode at mass transitions m/z 1083.5→268.9 and 1181.5→269.0, respectively, on an AB Sciex QTrap 5500. The assay range was 0.5-500 ng/mL and proved to be linear (r(2)>0.996), accurate (≤10% deviation), and precise (CV<15%). Mithramycin was stable in plasma at room temperature for 24 h, as well as through three freeze-thaw cycles. This method was subsequently used to quantitate mithramycin plasma concentrations from patients enrolled on two clinical trials at the NCI.
Published by Elsevier B.V.
JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
AU - Roth, Jeffrey
AU - Peer, Cody J
AU - Widemann, Brigitte
AU - Cole, Diane E
AU - Ershler, Rachel
AU - Helman, Lee
AU - Schrump, David
AU - Figg, William D
AD - Clinical Pharmacology Program, National Cancer Institute, Bethesda, MD, United States. ; Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, United States. ; Thoracic Oncology Branch, National Cancer Institute, Bethesda, MD, United States. ; Clinical Pharmacology Program, National Cancer Institute, Bethesda, MD, United States. Electronic address: figgw@helix.nih.gov.
Y1 - 2014/11/01/
PY - 2014
DA - 2014 Nov 01
SP - 95
EP - 101
VL - 970
KW - Blood Proteins
KW - 0
KW - Plicamycin
KW - NIJ123W41V
KW - Index Medicus
KW - Mithramycin
KW - Tandem mass spectrometry
KW - Ultra-HPLC
KW - Sensitivity and Specificity
KW - Reproducibility of Results
KW - Humans
KW - Linear Models
KW - Solid Phase Extraction
KW - Blood Proteins -- metabolism
KW - Plicamycin -- chemistry
KW - Plicamycin -- pharmacokinetics
KW - Tandem Mass Spectrometry -- methods
KW - Chromatography, High Pressure Liquid -- methods
KW - Plicamycin -- blood
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-05-27
N1 - Date created - 2014-10-06
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.jchromb.2014.08.021
ER -
TY - JOUR
T1 - Necrotizing myopathies: beyond statins.
AN - 1566109435; 25203117
AB - This review discusses the spectrum of diseases associated with a necrotizing muscle biopsy. Although patients with toxic myopathies, endocrine dysfunction, and heritable myopathies may have prominent necrosis on muscle biopsy, immune-mediated myopathies are emphasized here.
A decade ago, immune-mediated necrotizing myopathy was recognized as a distinct form of myositis. Recent evidence now suggests that immune-mediated necrotizing myopathy is not one disease, but can be divided on the basis of the presence of distinct autoantibodies recognizing either the signal recognition particle or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Anti-HMG-CoA reductase-positive patients can be further subdivided into those with and without statin exposure, the latter of which may be particularly refractory to immunosuppressive therapy. A significant number of patients with autoimmune myopathy have a predominantly necrotizing muscle biopsy with minimal lymphocytic infiltration. This biopsy finding occurs in various forms myositis, including the antisynthetase syndrome, scleroderma-associated myopathy, antisignal recognition particle-associated myopathy, statin-associated anti-HMG-CoA reductase-positive autoimmune myopathy, and statin-naïve anti-HMG-CoA reductase-positive myopathy. Future progress in elucidating pathogenic mechanisms and defining optimal treatment strategies may depend upon recognizing these distinct forms of myositis and analyzing them as separate entities.
JF - Current opinion in rheumatology
AU - Mammen, Andrew L
AD - Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Expression, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 679
EP - 683
VL - 26
IS - 6
KW - Index Medicus
KW - Humans
KW - Muscular Diseases -- pathology
KW - Muscle, Skeletal -- pathology
KW - Muscular Diseases -- immunology
KW - Autoimmune Diseases -- pathology
KW - Muscle, Skeletal -- immunology
KW - Autoimmune Diseases -- immunology
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-06-10
N1 - Date created - 2014-09-25
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1097/BOR.0000000000000106
ER -
TY - JOUR
T1 - Induced pluripotency enables differentiation of human nullipotent embryonal carcinoma cells N2102Ep.
AN - 1561032450; 25086345
AB - Embryonal carcinoma (EC) cells, which are considered to be malignant counterparts of embryonic stem cells, comprise the pluripotent stem cell component of teratocarcinomas, a form of testicular germ cell tumors (GCTs). Nevertheless, many established human EC cell lines are nullipotent with limited or no capacity to differentiate under normal circumstances. In this study, we tested whether an over-expression of Yamanaka's reprogramming factors OCT4, SOX2, c-MYC and KLF4 might enable differentiation of the human nullipotent EC cells N2102Ep. Using OCT4 knockdown differentiated N2102Ep cells, we are able to derive reprogrammed N2102Ep cell lines. The induced pluripotency of N2102Ep allows the cells to differentiate toward neural lineage by retinoic acid; the expression of SSEA3 and SSEA4 is down-regulated, whereas that of neural surface markers is up-regulated. Consistent with the up-regulation of neural surface markers, the expression of the master neuroectodermal transcription factor PAX6 is also induced in reprogrammed N2102Ep. We next investigated whether PAX6 might induce spontaneous differentiation of nullipotent stem cells N2102Ep. However, while an ectopic expression of PAX6 promotes differentiation of NTERA2, it induces cell death in N2102Ep. We nevertheless find that upon induction of retinoic acid, the reprogrammed N2102Ep cells form mature neuronal morphology similar to differentiated pluripotent stem cells NTERA2 as determined by TUJ1 expression, which is absent in N2102Ep parental cells. Altogether, we conclude that the nullipotent state of human EC cells can be reprogrammed to acquire a more relaxed state of differentiation potential by Yamanaka's factors.
Copyright © 2014 Elsevier B.V. All rights reserved.
JF - Biochimica et biophysica acta
AU - Sutiwisesak, Rujapope
AU - Kitiyanant, Narisorn
AU - Kotchabhakdi, Naiphinich
AU - Felsenfeld, Gary
AU - Andrews, Peter W
AU - Wongtrakoongate, Patompon
AD - Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhonpathom 73170, Thailand; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ; Stem Cell Research Group, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhonpathom, 73170, Thailand. ; Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhonpathom 73170, Thailand. ; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ; Centre for Stem Cell Biology, University of Sheffield, S10 2TN, UK. ; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Centre for Stem Cell Biology, University of Sheffield, S10 2TN, UK. Electronic address: p.wongtrakoongate@gmail.com.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 2611
EP - 2619
VL - 1843
IS - 11
SN - 0006-3002, 0006-3002
KW - Index Medicus
KW - Embryonal carcinoma cell
KW - Nullipotency
KW - Induced pluripotency
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561032450?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Induced+pluripotency+enables+differentiation+of+human+nullipotent+embryonal+carcinoma+cells+N2102Ep.&rft.au=Sutiwisesak%2C+Rujapope%3BKitiyanant%2C+Narisorn%3BKotchabhakdi%2C+Naiphinich%3BFelsenfeld%2C+Gary%3BAndrews%2C+Peter+W%3BWongtrakoongate%2C+Patompon&rft.aulast=Sutiwisesak&rft.aufirst=Rujapope&rft.date=2014-11-01&rft.volume=1843&rft.issue=11&rft.spage=2611&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbamcr.2014.07.013
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date created - 2014-09-08
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.bbamcr.2014.07.013
ER -
TY - JOUR
T1 - Adjusting serum concentrations of organochlorine compounds by lipids and symptoms: a causal framework for the association with K-ras mutations in pancreatic cancer.
AN - 1553106665; 25113205
AB - In clinically aggressive diseases, patients experience pathophysiological changes that often alter concentrations of lipids and environmental lipophilic factors; such changes are related to disease signs and symptoms. The aim of the study was to compare the effects of correcting for total serum lipids (TSL) and other clinical factors on the odds of mutations in the K-ras oncogene by organochlorine compounds (OCs), in logistic models, in 103 patients with exocrine pancreatic cancer (EPC) using a causal directed acyclic graph (DAG) framework. Results and likelihood of bias were discussed in the light of possible causal scenarios. The odds of K-ras mutated EPC was associated with some TSL-corrected OCs, including p,p'-DDT (p-value: 0.008) and polychlorinated biphenyl 138 (p-trend: 0.024). When OCs were not corrected by TSL, the OR of a K-ras mutation was significant for p,p'-DDT (p-trend: 0.035). Additionally adjusting for cholestatic syndrome increased the ORs of TSL-corrected OCs. When models were adjusted by the interval from first symptom to blood extraction (ISE), the ORs increased for both TSL-corrected and uncorrected OCs. Models with TSL-corrected OCs and adjusted for cholestatic syndrome or ISE yielded the highest ORs. We show that DAGs clarify the covariates necessary to minimize bias, and demonstrate scenarios under which adjustment for TSL-corrected OCs and failure to adjust for symptoms or ISE may induce bias. Models with TSL-uncorrected OCs may be biased too, and adjusting by symptoms or ISE may not control such biases. Our findings may have implications as well for studying environmental causes of other clinically aggressive diseases.
Copyright © 2014 Elsevier Ltd. All rights reserved.
JF - Chemosphere
AU - López, Tomàs
AU - Pumarega, José A
AU - Pollack, Anna Z
AU - Lee, Duk-Hee
AU - Richiardi, Lorenzo
AU - Jacobs, David R
AU - Schisterman, Enrique F
AU - Porta, Miquel
AD - Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Catalonia, Spain. ; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. ; Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA. ; Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. ; Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Torino, Italy. ; Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, USA. ; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Catalonia, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: mporta@imim.es.
Y1 - 2014/11//
PY - 2014
DA - November 2014
SP - 219
EP - 225
VL - 114
KW - Environmental Pollutants
KW - 0
KW - Hydrocarbons, Chlorinated
KW - Lipids
KW - ras Proteins
KW - EC 3.6.5.2
KW - Index Medicus
KW - Organochlorine compounds
KW - Pancreatic neoplasm
KW - Disease progression
KW - Causal directed acyclic graph (DAG)
KW - K-ras gene
KW - Pancreas -- pathology
KW - ras Proteins -- genetics
KW - Logistic Models
KW - Pancreas -- metabolism
KW - Humans
KW - Lipids -- blood
KW - Pancreatic Neoplasms -- pathology
KW - Hydrocarbons, Chlorinated -- toxicity
KW - Environmental Pollutants -- toxicity
KW - Pancreatic Neoplasms -- blood
KW - Hydrocarbons, Chlorinated -- blood
KW - Genes, ras -- drug effects
KW - Pancreatic Neoplasms -- chemically induced
KW - Pancreatic Neoplasms -- genetics
KW - Mutation
KW - Environmental Pollutants -- blood
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Adjusting+serum+concentrations+of+organochlorine+compounds+by+lipids+and+symptoms%3A+a+causal+framework+for+the+association+with+K-ras+mutations+in+pancreatic+cancer.&rft.au=L%C3%B3pez%2C+Tom%C3%A0s%3BPumarega%2C+Jos%C3%A9+A%3BPollack%2C+Anna+Z%3BLee%2C+Duk-Hee%3BRichiardi%2C+Lorenzo%3BJacobs%2C+David+R%3BSchisterman%2C+Enrique+F%3BPorta%2C+Miquel&rft.aulast=L%C3%B3pez&rft.aufirst=Tom%C3%A0s&rft.date=2014-11-01&rft.volume=114&rft.issue=&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2014.04.066
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-10-28
N1 - Date created - 2014-08-12
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.chemosphere.2014.04.066
ER -
TY - JOUR
T1 - Enhanced neonatal Fc receptor function improves protection against primate SHIV infection.
AN - 1619316990; 25119033
AB - To protect against human immunodeficiency virus (HIV-1) infection, broadly neutralizing antibodies (bnAbs) must be active at the portals of viral entry in the gastrointestinal or cervicovaginal tracts. The localization and persistence of antibodies at these sites is influenced by the neonatal Fc receptor (FcRn), whose role in protecting against infection in vivo has not been defined. Here, we show that a bnAb with enhanced FcRn binding has increased gut mucosal tissue localization, which improves protection against lentiviral infection in non-human primates. A bnAb directed to the CD4-binding site of the HIV-1 envelope (Env) protein (denoted VRC01) was modified by site-directed mutagenesis to increase its binding affinity for FcRn. This enhanced FcRn-binding mutant bnAb, denoted VRC01-LS, displayed increased transcytosis across human FcRn-expressing cellular monolayers in vitro while retaining FcγRIIIa binding and function, including antibody-dependent cell-mediated cytotoxicity (ADCC) activity, at levels similar to VRC01 (the wild type). VRC01-LS had a threefold longer serum half-life than VRC01 in non-human primates and persisted in the rectal mucosa even when it was no longer detectable in the serum. Notably, VRC01-LS mediated protection superior to that afforded by VRC01 against intrarectal infection with simian-human immunodeficiency virus (SHIV). These findings suggest that modification of FcRn binding provides a mechanism not only to increase serum half-life but also to enhance mucosal localization that confers immune protection. Mutations that enhance FcRn function could therefore increase the potency and durability of passive immunization strategies to prevent HIV-1 infection.
JF - Nature
AU - Ko, Sung-Youl
AU - Pegu, Amarendra
AU - Rudicell, Rebecca S
AU - Yang, Zhi-yong
AU - Joyce, M Gordon
AU - Chen, Xuejun
AU - Wang, Keyun
AU - Bao, Saran
AU - Kraemer, Thomas D
AU - Rath, Timo
AU - Zeng, Ming
AU - Schmidt, Stephen D
AU - Todd, John-Paul
AU - Penzak, Scott R
AU - Saunders, Kevin O
AU - Nason, Martha C
AU - Haase, Ashley T
AU - Rao, Srinivas S
AU - Blumberg, Richard S
AU - Mascola, John R
AU - Nabel, Gary J
AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 4502, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA. ; 1] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 4502, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA [2] Sanofi, 640 Memorial Drive, Cambridge, Massachusetts 02139, USA (R.S.R., Z.-Y.Y. and G.J.N.); Center for Genetics of Host Defense, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235-8505, USA (M.Z.); University of North Texas System College of Pharmacy, 3500 Camp Bowie Boulevard, RES-340J, Fort Worth, Texas 76107, USA (S.R.P.). ; Division of Gastroenterology, Department of Medicine, Brigham &Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA. ; 1] Department of Microbiology, Medical School, University of Minnesota, 420 Delaware Street South East, Minneapolis, Minnesota 55455, USA [2] Sanofi, 640 Memorial Drive, Cambridge, Massachusetts 02139, USA (R.S.R., Z.-Y.Y. and G.J.N.); Center for Genetics of Host Defense, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235-8505, USA (M.Z.); University of North Texas System College of Pharmacy, 3500 Camp Bowie Boulevard, RES-340J, Fort Worth, Texas 76107, USA (S.R.P.). ; 1] Clinical Pharmacokinetics Laboratory, Pharmacy Department, Clinical Center, National Institutes of Health, Building 10, 10 Center Drive, Bethesda, Maryland 20814, USA [2] Sanofi, 640 Memorial Drive, Cambridge, Massachusetts 02139, USA (R.S.R., Z.-Y.Y. and G.J.N.); Center for Genetics of Host Defense, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235-8505, USA (M.Z.); University of North Texas System College of Pharmacy, 3500 Camp Bowie Boulevard, RES-340J, Fort Worth, Texas 76107, USA (S.R.P.). ; Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6700A Rockledge Drive, Room 5235, Bethesda, Maryland 20892, USA. ; Department of Microbiology, Medical School, University of Minnesota, 420 Delaware Street South East, Minneapolis, Minnesota 55455, USA.
Y1 - 2014/10/30/
PY - 2014
DA - 2014 Oct 30
SP - 642
EP - 645
VL - 514
IS - 7524
KW - Antibodies, Neutralizing
KW - 0
KW - Antibodies, Viral
KW - Antigens, CD4
KW - FCGR3A protein, human
KW - Fc receptor, neonatal
KW - HIV Antibodies
KW - HIV Envelope Protein gp160
KW - Histocompatibility Antigens Class I
KW - Receptors, Fc
KW - Receptors, IgG
KW - Index Medicus
KW - Animals
KW - Receptors, IgG -- immunology
KW - Transcytosis
KW - Receptors, IgG -- metabolism
KW - Administration, Rectal
KW - Antigens, CD4 -- metabolism
KW - Mutagenesis, Site-Directed
KW - HIV Antibodies -- blood
KW - Half-Life
KW - Immunity, Mucosal -- immunology
KW - Macaca mulatta
KW - Binding Sites -- genetics
KW - Male
KW - Simian Immunodeficiency Virus -- immunology
KW - HIV Envelope Protein gp160 -- immunology
KW - HIV -- immunology
KW - Intestinal Mucosa -- immunology
KW - HIV Antibodies -- genetics
KW - Rectum -- immunology
KW - Mice
KW - Antibody Affinity -- immunology
KW - Antibody Affinity -- genetics
KW - HIV Antibodies -- immunology
KW - HIV Envelope Protein gp160 -- chemistry
KW - Immunization, Passive
KW - HIV Antibodies -- analysis
KW - Antibody-Dependent Cell Cytotoxicity -- immunology
KW - Female
KW - HIV -- chemistry
KW - Simian Acquired Immunodeficiency Syndrome -- immunology
KW - Antibodies, Neutralizing -- analysis
KW - Histocompatibility Antigens Class I -- immunology
KW - Simian Acquired Immunodeficiency Syndrome -- prevention & control
KW - Antibodies, Viral -- immunology
KW - Antibodies, Viral -- analysis
KW - Antibodies, Viral -- blood
KW - Receptors, Fc -- immunology
KW - Antibodies, Viral -- genetics
KW - Antibodies, Neutralizing -- genetics
KW - HIV Infections -- immunology
KW - HIV Infections -- prevention & control
KW - Antibodies, Neutralizing -- blood
KW - Antibodies, Neutralizing -- immunology
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1619316990?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Enhanced+neonatal+Fc+receptor+function+improves+protection+against+primate+SHIV+infection.&rft.au=Ko%2C+Sung-Youl%3BPegu%2C+Amarendra%3BRudicell%2C+Rebecca+S%3BYang%2C+Zhi-yong%3BJoyce%2C+M+Gordon%3BChen%2C+Xuejun%3BWang%2C+Keyun%3BBao%2C+Saran%3BKraemer%2C+Thomas+D%3BRath%2C+Timo%3BZeng%2C+Ming%3BSchmidt%2C+Stephen+D%3BTodd%2C+John-Paul%3BPenzak%2C+Scott+R%3BSaunders%2C+Kevin+O%3BNason%2C+Martha+C%3BHaase%2C+Ashley+T%3BRao%2C+Srinivas+S%3BBlumberg%2C+Richard+S%3BMascola%2C+John+R%3BNabel%2C+Gary+J&rft.aulast=Ko&rft.aufirst=Sung-Youl&rft.date=2014-10-30&rft.volume=514&rft.issue=7524&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=1476-4687&rft_id=info:doi/10.1038%2Fnature13612
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-12-04
N1 - Date created - 2014-10-30
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
J Immunol. 2006 Jan 1;176(1):346-56 [16365427]
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Vaccine. 2007 Feb 9;25(8):1398-408 [17113201]
Nat Rev Immunol. 2007 Sep;7(9):715-25 [17703228]
Nature. 2007 Sep 6;449(7158):101-4 [17805298]
Nat Rev Immunol. 2008 Jan;8(1):34-47 [18064051]
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PLoS Pathog. 2009 May;5(5):e1000433 [19436712]
Adv Immunol. 2009;103:77-115 [19755184]
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J Virol. 2010 Feb;84(3):1302-13 [19906907]
J Virol. 2010 Feb;84(3):1439-52 [19939925]
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J Virol. 2013 Nov;87(21):11604-16 [23966410]
Antimicrob Agents Chemother. 2013 Dec;57(12):6147-53 [24080653]
Immunity. 2013 Dec 12;39(6):1095-107 [24290911]
Sci Transl Med. 2014 Jul 2;6(243):243ra88 [24990883]
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J Immunol. 2002 Nov 1;169(9):5171-80 [12391234]
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1038/nature13612
ER -
TY - JOUR
T1 - Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes.
AN - 1561972937; 25063738
AB - The role of microRNAs (miRNAs) in carcinogenesis as tumor suppressors or oncogenes has been widely reported. Epigenetic change is one of the mechanisms of transcriptional silencing of miRNAs in cancer. To identify lung cancer-related miRNAs that are mediated by histone modification, we conducted microarray analysis in the Calu-6 non-small cell lung cancer (NSCLC) cell line after treatment with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor. The expression level of miR-373 was enhanced by SAHA treatment in this cell line by microarray and the following quantitative RT-PCR analyses. Treatment with another HDAC inhibitor, Trichostatin A, restored the levels of miR-373 expression in A549 and Calu-6 cells, while demethylation drug treatment did not. Importantly, miR-373 was found to be down-regulated in NSCLC tissues and cell lines. Transfection of miR-373 into A549 and Calu-6 cells attenuated cell proliferation, migration, and invasion and reduced the expression of mesenchymal markers. Additional microarray analysis of miR-373-transfected cells and computational predictions identified IRAK2 and LAMP1 as targets of miR-373. Knockdown of these two genes showed similar biological effects to those of miR-373 overexpression. In clinical samples, overexpression of IRAK2 correlated with decreased disease-free survival of patients with non-adenocarcinoma. In conclusion, we found that miR-373 is silenced by histone modification in lung cancer cells and identified its function as a tumor suppressor and negative regulator of the mesenchymal phenotype through downstream IRAK2 and LAMP1 target genes.
Published by Elsevier Ireland Ltd.
JF - Cancer letters
AU - Seol, Hyang Sook
AU - Akiyama, Yoshimitsu
AU - Shimada, Shu
AU - Lee, Hee Jin
AU - Kim, Tae Im
AU - Chun, Sung Min
AU - Singh, Shree Ram
AU - Jang, Se Jin
AD - Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, South Korea; Asan Center for Cancer Genome Discovery, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, South Korea. ; Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8519, Japan. ; Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, South Korea. ; Asan Center for Cancer Genome Discovery, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, South Korea. ; Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: singhshr@mail.nih.gov. ; Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, South Korea; Asan Center for Cancer Genome Discovery, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, South Korea. Electronic address: jangsejin@amc.seoul.kr.
Y1 - 2014/10/28/
PY - 2014
DA - 2014 Oct 28
SP - 232
EP - 241
VL - 353
IS - 2
KW - Histones
KW - 0
KW - LAMP1 protein, human
KW - Lysosome-Associated Membrane Glycoproteins
KW - MIRN373 microRNA, human
KW - MicroRNAs
KW - Interleukin-1 Receptor-Associated Kinases
KW - EC 2.7.11.1
KW - Index Medicus
KW - IRAK2
KW - LAMP1
KW - Histone deacetylase
KW - Non-small cell lung cancer
KW - microRNA-373
KW - Tumor suppressor
KW - Kaplan-Meier Estimate
KW - Gene Expression Regulation, Neoplastic
KW - Disease-Free Survival
KW - Humans
KW - Histones -- metabolism
KW - Protein Processing, Post-Translational
KW - Cell Line, Tumor
KW - Male
KW - Female
KW - Proportional Hazards Models
KW - Multivariate Analysis
KW - Epithelial-Mesenchymal Transition
KW - Carcinoma, Non-Small-Cell Lung -- metabolism
KW - MicroRNAs -- metabolism
KW - Carcinoma, Non-Small-Cell Lung -- mortality
KW - Lung Neoplasms -- mortality
KW - Lysosome-Associated Membrane Glycoproteins -- metabolism
KW - Epigenesis, Genetic
KW - Lung Neoplasms -- pathology
KW - Lung Neoplasms -- metabolism
KW - Interleukin-1 Receptor-Associated Kinases -- metabolism
KW - Carcinoma, Non-Small-Cell Lung -- pathology
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561972937?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Epigenetic+silencing+of+microRNA-373+to+epithelial-mesenchymal+transition+in+non-small+cell+lung+cancer+through+IRAK2+and+LAMP1+axes.&rft.au=Seol%2C+Hyang+Sook%3BAkiyama%2C+Yoshimitsu%3BShimada%2C+Shu%3BLee%2C+Hee+Jin%3BKim%2C+Tae+Im%3BChun%2C+Sung+Min%3BSingh%2C+Shree+Ram%3BJang%2C+Se+Jin&rft.aulast=Seol&rft.aufirst=Hyang&rft.date=2014-10-28&rft.volume=353&rft.issue=2&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=1872-7980&rft_id=info:doi/10.1016%2Fj.canlet.2014.07.019
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-11-11
N1 - Date created - 2014-09-11
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.canlet.2014.07.019
ER -
TY - JOUR
T1 - Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol.
AN - 1561969754; 25069035
AB - Recently we found that mice bearing subcutaneous non-metastatic tumors exhibited elevated levels of two types of complex DNA damage, i.e., double-strand breaks and oxidatively-induced clustered DNA lesions in various tissues throughout the body, both adjacent to and distant from the tumor site. This DNA damage was dependent on CCL2, a cytokine involved in the recruitment and activation of macrophages, suggesting that this systemic DNA damage was mediated via tumor-induced chronic inflammatory responses involving cytokines, activation of macrophages, and consequent free radical production. If free radicals are involved, then a diet containing an antioxidant may decrease the distant DNA damage. Here we repeated our standard protocol in cohorts of two syngeneic tumor-bearing C57BL/6NCr mice that were on a Tempol-supplemented diet. We show that double-strand break and oxidatively-induced clustered DNA lesion levels were considerably decreased, about two- to three fold, in the majority of tissues studied from the tumor-bearing mice fed the antioxidant Tempol compared to the control tumor-bearing mice. Similar results were also observed in nude mice suggesting that the Tempol effects are independent of functioning adaptive immunity. This is the first in vivo study demonstrating the effect of a dietary antioxidant on abscopal DNA damage in tissues distant from a localized source of genotoxic stress. These findings may be important for understanding the mechanisms of genomic instability and carcinogenesis caused by chronic stress-induced systemic DNA damage and for developing preventative strategies.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
JF - Cancer letters
AU - Georgakilas, Alexandros G
AU - Redon, Christophe E
AU - Ferguson, Nicholas F
AU - Kryston, Thomas B
AU - Parekh, Palak
AU - Dickey, Jennifer S
AU - Nakamura, Asako J
AU - Mitchell, James B
AU - Bonner, William M
AU - Martin, Olga A
AD - Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA; Department of Physics, National Technical University of Athens, Zografou Campus, Athens GR-15773, Greece. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. ; Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Office of In Vitro Diagnostics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Department of Biological Sciences, Faculty of Science, Ibaraki University, Ibaraki 310-8512, Japan. ; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Laboratory of Molecular Radiation Biology, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic. 3002, Australia. Electronic address: olga.martin@petermac.org.
Y1 - 2014/10/28/
PY - 2014
DA - 2014 Oct 28
SP - 248
EP - 257
VL - 353
IS - 2
KW - Antioxidants
KW - 0
KW - Cyclic N-Oxides
KW - Reactive Oxygen Species
KW - Spin Labels
KW - tempol
KW - U78ZX2F65X
KW - Index Medicus
KW - DNA damage
KW - Tumor-bearing mice
KW - Non-targeted effects
KW - Tempol
KW - Neoplasm Transplantation
KW - Reactive Oxygen Species -- metabolism
KW - Animals
KW - Gastrointestinal Tract -- pathology
KW - Gastrointestinal Tract -- drug effects
KW - Mice, Inbred C57BL
KW - Mice, Nude
KW - Mice
KW - Female
KW - Antioxidants -- pharmacology
KW - Cyclic N-Oxides -- pharmacology
KW - DNA Breaks, Double-Stranded
KW - Melanoma, Experimental -- genetics
KW - Carcinoma, Lewis Lung -- genetics
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561969754?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Systemic+DNA+damage+accumulation+under+in+vivo+tumor+growth+can+be+inhibited+by+the+antioxidant+Tempol.&rft.au=Georgakilas%2C+Alexandros+G%3BRedon%2C+Christophe+E%3BFerguson%2C+Nicholas+F%3BKryston%2C+Thomas+B%3BParekh%2C+Palak%3BDickey%2C+Jennifer+S%3BNakamura%2C+Asako+J%3BMitchell%2C+James+B%3BBonner%2C+William+M%3BMartin%2C+Olga+A&rft.aulast=Georgakilas&rft.aufirst=Alexandros&rft.date=2014-10-28&rft.volume=353&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=1872-7980&rft_id=info:doi/10.1016%2Fj.canlet.2014.07.030
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-11-11
N1 - Date created - 2014-09-11
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.canlet.2014.07.030
ER -
TY - CPAPER
T1 - Neutrophils in the Pathogenesis of Systemic Autoimmune Diseases
T2 - 2014 Joint Meeting of the Society for Leukocyte Biology and The International Endotoxin and Innate Immunity Society (SLB IEIIS 2014)
AN - 1645158836; 6316123
JF - 2014 Joint Meeting of the Society for Leukocyte Biology and The International Endotoxin and Innate Immunity Society (SLB IEIIS 2014)
AU - Kaplan, Mariana
Y1 - 2014/10/23/
PY - 2014
DA - 2014 Oct 23
KW - Autoimmune diseases
KW - Leukocytes (neutrophilic)
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Joint+Meeting+of+the+Society+for+Leukocyte+Biology+and+The+International+Endotoxin+and+Innate+Immunity+Society+%28SLB+IEIIS+2014%29&rft.atitle=Neutrophils+in+the+Pathogenesis+of+Systemic+Autoimmune+Diseases&rft.au=Kaplan%2C+Mariana&rft.aulast=Kaplan&rft.aufirst=Mariana&rft.date=2014-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Joint+Meeting+of+the+Society+for+Leukocyte+Biology+and+The+International+Endotoxin+and+Innate+Immunity+Society+%28SLB+IEIIS+2014%29&rft.issn=&rft_id=info:doi/
L2 - http://slbieiis2014.org/2014/PDFs-Images/2014-09-23-SLB-IEIIS-2014-Program.aspx
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - Jakinibs: Bedside to Genomic Switches
T2 - 2014 Joint Meeting of the Society for Leukocyte Biology and The International Endotoxin and Innate Immunity Society (SLB IEIIS 2014)
AN - 1645158626; 6316138
JF - 2014 Joint Meeting of the Society for Leukocyte Biology and The International Endotoxin and Innate Immunity Society (SLB IEIIS 2014)
AU - O'Shea, John
Y1 - 2014/10/23/
PY - 2014
DA - 2014 Oct 23
KW - genomics
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L2 - http://slbieiis2014.org/2014/PDFs-Images/2014-09-23-SLB-IEIIS-2014-Program.aspx
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - JOUR
T1 - A CXCR1 haplotype hampers HIV-1 matrix protein p17 biological activity.
AN - 1566824279; 25121556
AB - Monocyte inflammatory processes are fundamental events in AIDS pathogenesis. HIV-1 matrix protein p17, released from infected cells, was found to exert an interleukin (IL)-8 chemokine-like activity on human monocytes, promoting their trafficking and sustaining inflammatory processes, after binding to CXCR1. A haplotype of the CXCR1 gene (CXCR1_300_142) has been associated with slow HIV disease progression. Here, we determine how CXCR1 genetic variations impact on p17 biological activity.
Our results show that Jurkat cells overexpressing CXCR1 or the receptor carrying single polymorphism CXCR1_300 or CXCR1_142 are able to adhere and migrate in response to both IL-8 and p17. On the contrary, Jurkat cells overexpressing CXCR1_300_142 and monocytes of individuals with such CXCR1 polymorphisms lose the capacity to adhere and migrate in response to p17, but not to their physiological ligand IL-8. Surface plasmon resonance (SPR) and multispectral imaging flow cytometry showed that p17 bound with similar affinity to CXCR1 and CXCR1_300_142. Moreover, whereas p17 was able to activate CXCR1, it was incapable of functionally interacting with CXCR1_300_142 by phosphorylating extracellular signal-regulated kinase 1/2, which regulates chemokine-induced cellular responses. Finally, mutagenesis studies showed that, unlike IL-8, p17 does not use Glu-Leu-Arg-like motifs to activate CXCR1. Our results, showing the inability of p17 to activate CXCR1_300_142, a receptor found to be expressed on immune cells of patients with a low progression of HIV disease, point to a crucial role of p17 in AIDS pathogenesis. Our findings herein call for an exploration of the therapeutic potential of blocking the p17/CXCR1 axis in HIV infection.
2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
JF - AIDS (London, England)
AU - Giagulli, Cinzia
AU - Caccuri, Francesca
AU - Cignarella, Francesca
AU - Lougaris, Vassilios
AU - Martorelli, Debora
AU - Bugatti, Antonella
AU - Rusnati, Marco
AU - Dolcetti, Riccardo
AU - Vitali, Massimiliano
AU - Plebani, Alessandro
AU - Fiorentini, Simona
AU - Caruso, Arnaldo
AD - aSection of Microbiology, Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia bPediatrics Clinic and Institute for Molecular Medicine 'A. Nocivelli', Department of Clinical and Experimental Sciences, University of Brescia, Brescia cCancer Bio-Immunotherapy Unit, CRO-IRCCS, National Cancer Institute, Aviano (PN) dSection of Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy.
Y1 - 2014/10/23/
PY - 2014
DA - 2014 Oct 23
SP - 2355
EP - 2364
VL - 28
IS - 16
KW - HIV Antigens
KW - 0
KW - Interleukin-8
KW - Receptors, Interleukin-8A
KW - gag Gene Products, Human Immunodeficiency Virus
KW - p17 protein, Human Immunodeficiency Virus Type 1
KW - Index Medicus
KW - AIDS/HIV
KW - Cell Movement
KW - HIV Infections -- virology
KW - Humans
KW - HIV Infections -- immunology
KW - Surface Plasmon Resonance
KW - Jurkat Cells
KW - Flow Cytometry
KW - Interleukin-8 -- metabolism
KW - Protein Binding
KW - HIV Antigens -- physiology
KW - Receptors, Interleukin-8A -- genetics
KW - Receptors, Interleukin-8A -- metabolism
KW - Haplotypes
KW - gag Gene Products, Human Immunodeficiency Virus -- physiology
KW - gag Gene Products, Human Immunodeficiency Virus -- metabolism
KW - T-Lymphocytes -- virology
KW - HIV Antigens -- metabolism
KW - T-Lymphocytes -- immunology
KW - Host-Pathogen Interactions
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-06-01
N1 - Date created - 2014-09-30
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1097/QAD.0000000000000423
ER -
TY - JOUR
T1 - Characterization of Functional Reprogramming during Osteoclast Development Using Quantitative Proteomics and mRNA Profiling
AN - 1808675670; PQ0003450021
AB - In addition to forming macrophages and dendritic cells, monocytes in adult peripheral blood retain the ability to develop into osteoclasts, mature bone-resorbing cells. The extensive morphological and functional transformations that occur during osteoclast differentiation require substantial reprogramming of gene and protein expression. Here we employ -omic-scale technologies to examine in detail the molecular changes at discrete developmental stages in this process (precursor cells, intermediate osteoclasts, and multinuclear osteoclasts), quantitatively comparing their transcriptomes and proteomes. The data have been deposited to the ProteomeXchange with identifier PXD000471.Our analysis identified mitochondrial changes, along with several alterations in signaling pathways, as central to the development of mature osteoclasts, while also confirming changes in pathways previously implicated in osteoclast biology. In particular, changes in the expression of proteins involved in metabolism and redirection of energy flow from basic cellular function toward bone resorption appeared to play a key role in the switch from monocytic immune system function to specialized bone-turnover function. These findings provide new insight into the differentiation program involved in the generation of functional osteoclasts.
JF - Molecular and Cellular Proteomics
AU - An, Eunkyung
AU - Narayanan, Manikandan
AU - Manes, Nathan P
AU - Nita-Lazar, Aleksandra
AD - From the Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, nitalazarau@niaid.nih.gov
Y1 - 2014/10/20/
PY - 2014
DA - 2014 Oct 20
SP - 2687
EP - 2704
PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 United States
VL - 13
IS - 10
SN - 1535-9476, 1535-9476
KW - Biotechnology and Bioengineering Abstracts
KW - Macrophages
KW - Transformation
KW - Data processing
KW - Osteoclasts
KW - Immune system
KW - Mitochondria
KW - Developmental stages
KW - Peripheral blood
KW - Gene expression
KW - Dendritic cells
KW - Energy flow
KW - Osteoprogenitor cells
KW - Bone resorption
KW - Monocytes
KW - proteomics
KW - Osteoclastogenesis
KW - Metabolism
KW - Signal transduction
KW - W 30960:Bioinformatics & Computer Applications
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-07-01
N1 - Last updated - 2016-08-17
N1 - SubjectsTermNotLitGenreText - Transformation; Macrophages; Data processing; Immune system; Osteoclasts; Developmental stages; Mitochondria; Peripheral blood; Gene expression; Dendritic cells; Energy flow; Osteoprogenitor cells; Bone resorption; proteomics; Monocytes; Osteoclastogenesis; Metabolism; Signal transduction
DO - http://dx.doi.org/10.1074/mcp.M113.034371
ER -
TY - JOUR
T1 - A case-control study of occupational exposure to metalworking fluids and bladder cancer risk among men
AN - 1808660494; PQ0003443722
AB - ObjectivesMetalworking has been associated with an excess risk of bladder cancer in over 20 studies. Metalworking fluids (MWFs) are suspected as the responsible exposure, but epidemiological data are limited. We investigated this association among men in the New England Bladder Cancer Study using state-of-the-art, quantitative exposure assessment methods.MethodsCases (n=895) and population controls (n=1031) provided occupational histories during personal interviews. For selected jobs, exposure-oriented modules were administered to collect information on use of three MWF types: (1) straight (mineral oil, additives), (2) soluble (mineral oil, water, additives) and (3) synthetic (water, organics, additives) or semisynthetic (hybrid of soluble and synthetic). We computed ORs and 95% CIs relating bladder cancer risk to a variety of exposure metrics, adjusting for smoking and other factors. Non-metalworkers who had held jobs with possible exposure to mineral oil were analysed separately.ResultsBladder cancer risk was elevated among men who reported using straight MWFs (OR=1.7, 95% CI 1.1 to 2.8); risk increased monotonically with increasing cumulative exposure (p=0.041). Use of soluble MWFs was associated with a 50% increased risk (95% CI 0.96 to 2.5). ORs were non-significantly elevated for synthetic/semisynthetic MWFs based on a small number of exposed men. Non-metalworkers holding jobs with possible exposure to mineral oil had a 40% increased risk (95% CI 1.1 to 1.8).ConclusionsExposure to straight MWFs was associated with a significantly increased bladder cancer risk, as was employment in non-metalworking jobs with possible exposure to mineral oil. These findings strengthen prior evidence for mineral oil as a bladder carcinogen.
JF - Occupational and Environmental Medicine
AU - Colt, Joanne S
AU - Friesen, Melissa C
AU - Stewart, Patricia A
AU - Donguk, Park
AU - Johnson, Alison
AU - Schwenn, Molly
AU - Karagas, Margaret R
AU - Armenti, Karla
AU - Waddell, Richard
AU - Verrill, Castine
AU - Ward, Mary H
AU - Beane Freeman, Laura E
AU - Moore, Lee E
AU - Koutros, Stella
AU - Baris, Dalsu
AU - Silverman, Debra T
AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Y1 - 2014/10/20/
PY - 2014
DA - 2014 Oct 20
SP - 667
EP - 674
PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom
VL - 71
IS - 10
SN - 1351-0711, 1351-0711
KW - Toxicology Abstracts; Health & Safety Science Abstracts
KW - Risk assessment
KW - Historical account
KW - mineral oil
KW - Data processing
KW - Urinary bladder
KW - Males
KW - Employment
KW - Carcinogens
KW - Metal-working fluids
KW - Cancer
KW - Oil
KW - Health risks
KW - Smoking
KW - Population control
KW - USA, New England
KW - Risk factors
KW - Hybrids
KW - Additives
KW - Minerals
KW - Occupational exposure
KW - X 24380:Social Poisons & Drug Abuse
KW - H 1000:Occupational Safety and Health
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=A+case-control+study+of+occupational+exposure+to+metalworking+fluids+and+bladder+cancer+risk+among+men&rft.au=Colt%2C+Joanne+S%3BFriesen%2C+Melissa+C%3BStewart%2C+Patricia+A%3BDonguk%2C+Park%3BJohnson%2C+Alison%3BSchwenn%2C+Molly%3BKaragas%2C+Margaret+R%3BArmenti%2C+Karla%3BWaddell%2C+Richard%3BVerrill%2C+Castine%3BWard%2C+Mary+H%3BBeane+Freeman%2C+Laura+E%3BMoore%2C+Lee+E%3BKoutros%2C+Stella%3BBaris%2C+Dalsu%3BSilverman%2C+Debra+T&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2014-10-20&rft.volume=71&rft.issue=10&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2013-102056
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2016-07-01
N1 - Last updated - 2016-09-01
N1 - SubjectsTermNotLitGenreText - Smoking; mineral oil; Data processing; Urinary bladder; Hybrids; Carcinogens; Occupational exposure; Cancer; Risk assessment; Historical account; Males; Employment; Metal-working fluids; Oil; Health risks; Population control; Risk factors; Minerals; Additives; USA, New England
DO - http://dx.doi.org/10.1136/oemed-2013-102056
ER -
TY - JOUR
T1 - Formation of epichlorohydrin, a known rodent carcinogen, following oral administration of 1,3-dichloro-2-propanol in rats.
AN - 1614699869; 25254956
AB - The observed toxicity and carcinogenicity of 1,3-dichloro-2-propanol (DCP) in rodents is thought to be due to the formation of reactive metabolites, epichlorohydrin (ECH) and dichloroacetone (DCA). However, there is no direct evidence for the formation of these metabolites from exposure to DCP in rodents due to the challenges of measuring these reactive intermediates directly in vivo. The objective of this work was to investigate the metabolism of DCP to ECH and DCA in vivo by first developing a sensitive analytical method in a suitable biological matrix and analyzing samples from rats administered DCP. DCA reacted rapidly in vitro in rat blood, plasma, and liver homogenate, precluding its detection. Because ECH rapidly disappeared in liver homogenate, but was relatively long-lived in plasma and blood in vitro, blood was selected for analysis of this metabolite. Following a single oral dose of 50 mg/kg DCP in male or female Harlan Sprague-Dawley rats, ECH was detected in blood with a maximum concentration reached at ≤13.7 min. ECH was cleared rapidly with a half-life of ca. 33 and 48 min in males and females, respectively. Following a single oral dose of 25 mg/kg ECH in male and female rats, the elimination half-life of ECH was ca. 34 and 20 min, respectively; the oral bioavailability of ECH was low (males, 5.2%; females, 2.1%), suggesting extensive first pass metabolism of ECH following oral administration. The area under the concentration vs time curve for ECH following oral administration of DCP and intravenous administration of ECH was used to estimate the percent of the DCP dose converted to ECH in rats. On the basis of this analysis, we concluded that in male and female rats following oral administration of 50 mg/kg DCP, ≥1.26% or ≥1.78% of the administered dose was metabolized to ECH, respectively.
JF - Chemical research in toxicology
AU - Waidyanatha, Suramya
AU - Gaudette, Norman F
AU - Hong, Yan
AU - Fennell, Timothy R
AD - Division of National Toxicology Program, National Institute of Environmental Health Sciences , Research Triangle Park, North Carolina 27709, United States.
Y1 - 2014/10/20/
PY - 2014
DA - 2014 Oct 20
SP - 1787
EP - 1795
VL - 27
IS - 10
KW - Epichlorohydrin
KW - 08OOR508C0
KW - 1,3-dichloro-2-propanol
KW - 0F4P2VQC07
KW - alpha-Chlorohydrin
KW - 96-24-2
KW - Index Medicus
KW - Administration, Oral
KW - Animals
KW - Serum -- metabolism
KW - Area Under Curve
KW - ROC Curve
KW - Liver -- metabolism
KW - Mice
KW - Administration, Intravenous
KW - Rats
KW - Rats, Sprague-Dawley
KW - Half-Life
KW - Liver -- drug effects
KW - Gas Chromatography-Mass Spectrometry
KW - Female
KW - Male
KW - alpha-Chlorohydrin -- analogs & derivatives
KW - Epichlorohydrin -- toxicity
KW - Epichlorohydrin -- metabolism
KW - alpha-Chlorohydrin -- metabolism
KW - Epichlorohydrin -- chemistry
KW - alpha-Chlorohydrin -- toxicity
KW - alpha-Chlorohydrin -- chemistry
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-06-23
N1 - Date created - 2014-10-20
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1021/tx500239q
ER -
TY - CPAPER
T1 - The Expansion of NIH's Genomic Data Sharing Policy
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167957; 6312499
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Luetkemeier, E
AU - Langlais, K
AU - Baker, R
AU - Fomous, C
AU - Paine, T
AU - Paltoo, D
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Policies
KW - Data processing
KW - genomics
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T1 - A mouse model of cblA class isolated methylmalonic acidemia (MMA) displays reduced survival, growth failure, renal disease and secondary mitochondrial dysfunction
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167849; 6312434
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Epping, M
AU - Wang, C
AU - Zerfas, P
AU - Elliot, G
AU - Li, L.
AU - Manoli, I
AU - Venditti, C
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Growth rate
KW - Kidney diseases
KW - Animal models
KW - Renal failure
KW - Mitochondria
KW - Survival
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T1 - Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167822; 6312672
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Wang, Z
AU - Zhang, M
AU - Zhu, B
AU - Parikh, H
AU - Jia, J
AU - Chung, C
AU - Sampson, J
AU - Hoskins, J
AU - Hutchinson, A
AU - Burdette, L
AU - Kraft, P
AU - Chanock, S
AU - Landi, M
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Health risks
KW - Association analysis
KW - Chromosomes
KW - chromosome 5
KW - Cancer
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T1 - Alignment to an Ancestry Specific Reference Genome Discovers Additional Variants Among 1000 Genomes ASW Cohort
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167758; 6312321
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Neff, R
AU - Vargas, J
AU - Gibbons, G
AU - Davis, A
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Genomes
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T1 - DbGaP Genotype Fingerprint Collection
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167715; 6312373
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Jin, Y
AU - Stefanov, S
AU - Dracheva, S
AU - Wang, Z
AU - Sharopova, N
AU - Sturcke, A
AU - Sherry, S
AU - Feolo, M
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Genotypes
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T1 - A novel variant in tenascin-X may be associated with an Ehlers Danlos phenotype in patients with congenital adrenal hyperplasia
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167687; 6312417
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Morissette, R
AU - Chen, W
AU - Xu, Z.
AU - McDonnell, N
AU - Merke, D
AU - Quezado, M
AU - Dreiling, J
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Hyperplasia
KW - Phenotypes
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T1 - Complex dynamics of meiotic recombination initiation in laboratory mouse strains
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167681; 6312508
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Brick, K
AU - Smagulova, F
AU - Camerini-Otero, R
AU - Petukhova, G
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Recombination
KW - Meiosis
KW - Strains
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T1 - Genome: Unlocking Life's Code - A Museum Exhibition as a Model for Informal Genomics Education
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167516; 6312611
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Bonham, V
AU - Easter, C
AU - Schonman, E
AU - Daulton, C
AU - Wise, R
AU - Hurle, B
AU - Witherly, J
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Genomes
KW - Education
KW - Museums
KW - genomics
KW - Models
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T1 - Using zebrafish to assess novel therapeutics and model the eye disease of cblC disease
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167507; 6312680
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Achilly, N
AU - Sloan, J
AU - Bishop, K
AU - Jones, M
AU - Sood, R
AU - Venditti, C
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Eye diseases
KW - Freshwater fish
KW - Models
KW - Danio rerio
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T1 - Genetic Heritability of Common Non-Hodgkin Lymphoma Subtypes
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167487; 6312587
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Berndt, S
AU - Morton, L
AU - Slager, S
AU - Smedby, K
AU - Miligi, L
AU - Albanes, D
AU - Brooks-Wilson, A
AU - Monnereau, A
AU - Birmann, B
AU - Purdue, M
AU - Vajdic, C
AU - Skibola, C
AU - Cerhan, J
AU - Chanock, S
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Non-Hodgkin's lymphoma
KW - Lymphoma
KW - Heritability
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T1 - A mutation in transferrin receptor 1 that disrupts iron internalization causes a novel immunodeficiency
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167432; 6312365
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Boyden, S
AU - Jabara, H
AU - Notarangelo, L
AU - Fleming, M
AU - Kunkel, L
AU - Geha, R
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Transferrin receptors
KW - Immunodeficiency
KW - Iron
KW - Mutation
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T1 - Aberrant DNA hypermethylation of SDHC: A novel mechanism of tumor development in Carney Triad
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167394; 6312669
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Faucz, F
AU - Haller, F
AU - Moskalev, E
AU - Batthelmeb, S
AU - Wiemann, S
AU - Bieg, M
AU - Bertherat, J
AU - Schaefer, I.-M.
AU - Maher, E
AU - Werner, M
AU - Carney, J
AU - Hartmann, A
AU - Agamy, A
AU - Stratakis, C
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Tumors
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T1 - Using a population-based linkage analysis approach to identify transcript QTL in skeletal muscle tissues in a founder population
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167390; 6312310
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Hsueh, W.-C.
AU - Kobes, S
AU - Hanson, R
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Quantitative trait loci
KW - Linkage analysis
KW - Transcription
KW - Skeletal muscle
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L2 - http://www.ashg.org/cgi-bin/2014/ashg14SOE.pl
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - A genome-wide scan identifies NFIB as important for metastasis in osteosarcoma patients
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167347; 6312588
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Mirabello, L
AU - Spector, L
AU - Meltzer, P
AU - Largaespada, D
AU - Gastier-Foster, J
AU - Flanagan, A
AU - Andrulis, I
AU - Wunder, J
AU - Lecanda, F
AU - de Toledo, S.
AU - Serra, M
AU - Wacholder, S
AU - Hoover, R
AU - Savage, S
AU - Helman, L
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Metastases
KW - Osteosarcoma
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L2 - http://www.ashg.org/cgi-bin/2014/ashg14SOE.pl
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - RAB11FIP1 interacts with the BLOC-1 complex to retrieve melanogenic proteins from the recycling pathway and a dominant negative mutation in RAB11FIP1 causes Hermanksy-Pudlak Syndrome Type 10 (HPS-10)
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167283; 6312523
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Cullinane, A
AU - Merideth, M
AU - Datiles, M
AU - Curry, J
AU - Hansen, N
AU - Teer, J
AU - White, J
AU - Mullikin, J
AU - Huizing, M
AU - Gahl, W
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Symptoms
KW - Recycling
KW - Mutation
KW - Waste management
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L2 - http://www.ashg.org/cgi-bin/2014/ashg14SOE.pl
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - Data Sharing and dbGaP: A Survey of Practices and Opinions Among Human Geneticists
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645167230; 6312500
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Kaufman, D
AU - Bollinger, J
AU - Dvoskin, R
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Data processing
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L2 - http://www.ashg.org/cgi-bin/2014/ashg14SOE.pl
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - Individualized iterative phenotyping for genome-wide analysis of loss of function mutations
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645165351; 6312330
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Johnston, J
AU - Singh, L
AU - Brownell, I
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Phenotyping
KW - Mutation
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L2 - http://www.ashg.org/cgi-bin/2014/ashg14SOE.pl
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - TRNT1 missense mutations define an autoinflammatory disease characterized by recurrent fever, severe anemia, and B-cell immunodeficiency
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645165341; 6312366
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Stoffels, M
AU - Zhou, Q
AU - Sediva, A
AU - Pelletier, M
AU - Sood, R
AU - Kastner, D
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Fever
KW - Missense mutation
KW - Lymphocytes B
KW - Immunodeficiency
KW - Anemia
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L2 - http://www.ashg.org/cgi-bin/2014/ashg14SOE.pl
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - CPAPER
T1 - Genome-Wide Analysis in Africans Provides Novel Insight into the Genetic Basis of the Metabolic Syndrome
T2 - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AN - 1645165340; 6312564
JF - 2014 Annual Meeting of the American Society of Human Genetics (ASHG 2014)
AU - Tekola-Ayele, F
AU - Doumatey, A
AU - Chen, G
AU - Shriner, D
AU - Bentley, A
AU - Zhou, J
AU - Adeyemo, A
AU - Rotimi, C
Y1 - 2014/10/18/
PY - 2014
DA - 2014 Oct 18
KW - Symptoms
KW - Metabolic disorders
KW - Africa
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L2 - http://www.ashg.org/cgi-bin/2014/ashg14SOE.pl
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - JOUR
T1 - Development of an immunologically tolerated combination of fluorescent proteins for in vivo two-photon imaging.
AN - 1613941322; 25322934
AB - Combinations of fluorescent proteins (FPs) are routinely used for multi-parameter in vivo imaging experiments to visualize tagged proteins or cell populations of interest. Studies involving FPs are often limited by spectral overlap, toxicity, relative quantum efficiency, and the potential for immunological rejection upon transfer into a non-tolerant recipient. Here we evaluate the immunologic visibility of several commonly used FPs by the murine immune system and identify a spectrally compatible, immunologically tolerated combination of FPs well suited for in vivo two-photon imaging.
JF - Scientific reports
AU - Gossa, Selamawit
AU - Nayak, Debasis
AU - Zinselmeyer, Bernd H
AU - McGavern, Dorian B
AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Y1 - 2014/10/17/
PY - 2014
DA - 2014 Oct 17
SP - 6664
VL - 4
KW - Green Fluorescent Proteins
KW - 147336-22-9
KW - Index Medicus
KW - Animals
KW - Photons
KW - Fluorescence Resonance Energy Transfer
KW - Mice
KW - Immune Tolerance
KW - Immune System -- ultrastructure
KW - Green Fluorescent Proteins -- isolation & purification
KW - Green Fluorescent Proteins -- immunology
KW - Diagnostic Imaging
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LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-11-06
N1 - Date created - 2014-10-17
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1038/srep06664
ER -
TY - CPAPER
T1 - Exploiting anti-glycan immunity to improve cancer care
T2 - 66th Southeastern Regional Meeting of the American Chemical Society (SERMACS 2014)
AN - 1645167148; 6324702
JF - 66th Southeastern Regional Meeting of the American Chemical Society (SERMACS 2014)
AU - Gildersleeve, Jeff
Y1 - 2014/10/16/
PY - 2014
DA - 2014 Oct 16
KW - Immunity
KW - Cancer
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L2 - http://abstracts.acs.org/chem/sermacs2014/program/divisionindex.php?act=session&val=289700&prog=289700
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date revised - 2014-11-30
N1 - Last updated - 2015-01-14
ER -
TY - JOUR
T1 - Lipoxin Generation Is Related to Soluble Epoxide Hydrolase Activity in Severe Asthma
AN - 1614426148; 25162465
AB - Severe asthma is characterized by airway inflammatory responses associated with aberrant metabolism of arachidonic acid. Lipoxins (LX) are arachidonate-derived pro-resolving mediators that are decreased in severe asthma, yet mechanisms for defective LX biosynthesis and a means to increase LXs in severe asthma remain to be established.
To determine if oxidative stress and soluble epoxide hydrolase (sEH) activity are linked to decreased LX biosynthesis in severe asthma.
Aliquots of blood, sputum, and bronchoalveolar lavage fluid were obtained from asthma subjects for mediator determination. Select samples were exposed to t-butyl-hydroperoxide or sEH inhibitor (sEHI) before activation. Peripheral blood leukocyte-platelet aggregates were monitored by flow cytometry, and bronchial contraction was determined with cytokine-treated human lung sections.
8-Isoprostane levels in sputum supernatants were inversely related to LXA4 in severe asthma (r = -0.55; P = 0.03) and t-butyl-hydroperoxide decreased LXA4 and 15-epi-LXA4 biosynthesis by peripheral blood leukocytes. LXA4 and 15-epi-LXA4 levels were inversely related to sEH activity in sputum supernatants and sEHIs significantly increased 14,15-epoxy-eicosatrienoic acid and 15-epi-LXA4 generation by severe asthma whole blood and bronchoalveolar lavage fluid cells. The abundance of peripheral blood leukocyte-platelet aggregates was related to asthma severity. In a concentration-dependent manner, LXs significantly inhibited platelet-activating factor-induced increases in leukocyte-platelet aggregates (70.8% inhibition [LXA4 100 nM], 78.3% inhibition [15-epi-LXA4 100 nM]) and 15-epi-LXA4 markedly inhibited tumor necrosis factor-α-induced increases in bronchial contraction.
LX levels were decreased by oxidative stress and sEH activity. Inhibitors of sEH increased LXs that mediated antiphlogistic actions, suggesting a new therapeutic approach for severe asthma. Clinical trial registered with www.clinicaltrials.gov (NCT 00595114).
JF - American Journal of Respiratory and Critical Care Medicine
AU - Ono, Emiko
AU - Dutile, Stefanie
AU - Kazani, Shamsah
AU - Wechsler, Michael E
AU - Yang, Jun
AU - Hammock, Bruce D
AU - Douda, David Nobuhiro
AU - Tabet, Yacine
AU - Khaddaj-Mallat, Rayan
AU - Sirois, Marco
AU - Sirois, Chantal
AU - Rizcallah, Edmond
AU - Rousseau, Éric
AU - Martin, Richard
AU - Sutherland, E Rand
AU - Castro, Mario
AU - Jarjour, Nizar N
AU - Israel, Elliot
AU - Levy, Bruce D
Y1 - 2014/10/15/
PY - 2014
DA - 2014 Oct 15
SP - 886
EP - 97
CY - New York
PB - American Thoracic Society
VL - 190
IS - 8
SN - 1073449X
KW - Medical Sciences--Respiratory Diseases
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Lipoxin+Generation+Is+Related+to+Soluble+Epoxide+Hydrolase+Activity+in+Severe+Asthma&rft.au=Ono%2C+Emiko%3BDutile%2C+Stefanie%3BKazani%2C+Shamsah%3BWechsler%2C+Michael+E%3BYang%2C+Jun%3BHammock%2C+Bruce+D%3BDouda%2C+David+Nobuhiro%3BTabet%2C+Yacine%3BKhaddaj-Mallat%2C+Rayan%3BSirois%2C+Marco%3BSirois%2C+Chantal%3BRizcallah%2C+Edmond%3BRousseau%2C+%C3%89ric%3BMartin%2C+Richard%3BSutherland%2C+E+Rand%3BCastro%2C+Mario%3BJarjour%2C+Nizar+N%3BIsrael%2C+Elliot%3BLevy%2C+Bruce+D&rft.aulast=Ono&rft.aufirst=Emiko&rft.date=2014-10-15&rft.volume=190&rft.issue=8&rft.spage=886&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/
LA - English
DB - ProQuest Central
N1 - Copyright - Copyright American Thoracic Society Oct 15, 2014
N1 - Last updated - 2017-01-07
ER -
TY - JOUR
T1 - CD47 signaling regulates the immunosuppressive activity of VEGF in T cells.
AN - 1586100723; 25200950
AB - Thrombospondin-1 (TSP1) inhibits angiogenesis, in part, by interacting with the ubiquitous cell-surface receptor CD47. In endothelial cells, CD47 interacts directly with vascular endothelial growth factor receptor (VEGFR)-2, and TSP1 inhibits VEGFR2 phosphorylation and signaling by disrupting this association. We show that CD47 similarly associates with and regulates VEGFR2 in T cells. TSP1 inhibits phosphorylation of VEGFR2 and its downstream target Src in wild type but not in CD47-deficient human Jurkat and primary murine T cells. VEGFR2 signaling inhibits proliferation and TCR signaling in wild type T cells. However, ligation of CD47 by TSP1 or loss of CD47 expression reverses some inhibitory effects of VEGF on proliferation and T cell activation. We further found that VEGF and VEGFR2 expression are upregulated in CD47-deficient murine CD4(+) and human Jurkat T cells, and the resulting autocrine VEGFR2 signaling enhances proliferation and some TCR responses in the absence of CD47. Thus, CD47 signaling modulates the ability of VEGF to regulate proliferation and TCR signaling, and autocrine production of VEGF by T cells contributes to this regulation. This provides a mechanism to understand the context-dependent effects of TSP1 and VEGF on T cell activation, and reveals an important role for CD47 signaling in regulating T cell production of the major angiogenic factor VEGF.
JF - Journal of immunology (Baltimore, Md. : 1950)
AU - Kaur, Sukhbir
AU - Chang, Tiffany
AU - Singh, Satya P
AU - Lim, Langston
AU - Mannan, Poonam
AU - Garfield, Susan H
AU - Pendrak, Michael L
AU - Soto-Pantoja, David R
AU - Rosenberg, Avi Z
AU - Jin, Shelly
AU - Roberts, David D
AD - Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20982; ; Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982; and. ; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. ; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20982; droberts@helix.nih.gov.
Y1 - 2014/10/15/
PY - 2014
DA - 2014 Oct 15
SP - 3914
EP - 3924
VL - 193
IS - 8
KW - Antigens, CD47
KW - 0
KW - CD47 protein, human
KW - Receptors, Antigen, T-Cell
KW - Thrombospondin 1
KW - VEGFA protein, human
KW - Vascular Endothelial Growth Factor A
KW - KDR protein, human
KW - EC 2.7.10.1
KW - Vascular Endothelial Growth Factor Receptor-2
KW - src-Family Kinases
KW - EC 2.7.10.2
KW - Abridged Index Medicus
KW - Index Medicus
KW - Animals
KW - Humans
KW - Jurkat Cells
KW - Receptors, Antigen, T-Cell -- immunology
KW - Cell Line, Tumor
KW - Mice
KW - Cell Proliferation
KW - Mice, Knockout
KW - Neovascularization, Pathologic -- immunology
KW - Phosphorylation
KW - CD8-Positive T-Lymphocytes -- immunology
KW - Lymphocyte Activation -- immunology
KW - src-Family Kinases -- metabolism
KW - Signal Transduction -- immunology
KW - Up-Regulation
KW - Cell Communication -- immunology
KW - Vascular Endothelial Growth Factor A -- biosynthesis
KW - Antigens, CD47 -- genetics
KW - Vascular Endothelial Growth Factor Receptor-2 -- biosynthesis
KW - CD4-Positive T-Lymphocytes -- immunology
KW - Antigens, CD47 -- immunology
KW - Thrombospondin 1 -- immunology
KW - Antigens, CD47 -- biosynthesis
KW - Vascular Endothelial Growth Factor A -- immunology
KW - Vascular Endothelial Growth Factor Receptor-2 -- metabolism
KW - Immune Tolerance
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=CD47+signaling+regulates+the+immunosuppressive+activity+of+VEGF+in+T+cells.&rft.au=Kaur%2C+Sukhbir%3BChang%2C+Tiffany%3BSingh%2C+Satya+P%3BLim%2C+Langston%3BMannan%2C+Poonam%3BGarfield%2C+Susan+H%3BPendrak%2C+Michael+L%3BSoto-Pantoja%2C+David+R%3BRosenberg%2C+Avi+Z%3BJin%2C+Shelly%3BRoberts%2C+David+D&rft.aulast=Kaur&rft.aufirst=Sukhbir&rft.date=2014-10-15&rft.volume=193&rft.issue=8&rft.spage=3914&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.1303116
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-01-07
N1 - Date created - 2014-10-04
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.4049/jimmunol.1303116
ER -
TY - JOUR
T1 - Perfluorinated compounds: emerging POPs with potential immunotoxicity.
AN - 1563986924; 24503008
AB - Perfluorinated compounds (PFCs) have been recognized as an important class of environmental contaminants commonly detected in blood samples of both wildlife and humans. These compounds have been in use for more than 60 years as surface treatment chemicals, polymerization aids, and surfactants. They possess a strong carbon-fluorine bond, which leads to their environmental persistence. There is evidence from both epidemiology and laboratory studies that PFCs may be immunotoxic, affecting both cell-mediated and humoral immunity. Reported effects of PFCs include decreased spleen and thymus weights and cellularity, reduced specific antibody production, reduced survival after influenza infection, and altered cytokine production. Immunosuppression is a critical effect associated with exposure to PFCs, as it has been reported to reduce antibody responses to vaccination in children. Mounting evidence suggests that immunotoxicity in experimental animals can occur at serum concentrations below, within, or just above the reported range for highly exposed humans and wildlife. Considering bioaccumulation and exposure to multiple PFCs, the risk of immunotoxicity for humans and wildlife cannot be discounted. This review will discuss current and recently published work exploring the immunomodulatory effects of PFCs in experimental animals and humans.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
JF - Toxicology letters
AU - Corsini, Emanuela
AU - Luebke, Robert W
AU - Germolec, Dori R
AU - DeWitt, Jamie C
AD - Laboratory of Toxicology, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Italy. Electronic address: emanuela.corsini@unimi.it. ; U.S. Environmental Protection Agency/Office of Research and Development/National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA. ; National Toxicology Program, National Institute of Environmental Health Sciences, NIH, RTP, NC, USA. ; Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Y1 - 2014/10/15/
PY - 2014
DA - 2014 Oct 15
SP - 263
EP - 270
VL - 230
IS - 2
KW - Alkanesulfonic Acids
KW - 0
KW - Caprylates
KW - Fluorocarbons
KW - PPAR alpha
KW - perfluorooctanoic acid
KW - 947VD76D3L
KW - perfluorooctane sulfonic acid
KW - 9H2MAI21CL
KW - Index Medicus
KW - Cytokine
KW - PPAR-α receptor
KW - Vaccination
KW - Perfluorinated compounds
KW - Immunosuppression
KW - Animals
KW - Humans
KW - Alkanesulfonic Acids -- toxicity
KW - Caprylates -- toxicity
KW - PPAR alpha -- physiology
KW - Immune System -- drug effects
KW - Fluorocarbons -- toxicity
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Perfluorinated+compounds%3A+emerging+POPs+with+potential+immunotoxicity.&rft.au=Corsini%2C+Emanuela%3BLuebke%2C+Robert+W%3BGermolec%2C+Dori+R%3BDeWitt%2C+Jamie+C&rft.aulast=Corsini&rft.aufirst=Emanuela&rft.date=2014-10-15&rft.volume=230&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2014.01.038
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-11-25
N1 - Date created - 2014-09-19
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.toxlet.2014.01.038
ER -
TY - JOUR
T1 - Milestones in skin carcinogenesis: the biology of multistage carcinogenesis.
AN - 1612289764; 25302469
JF - The Journal of investigative dermatology
AU - Balmain, Allan
AU - Yuspa, Stuart H
AD - Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA. ; Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Y1 - 2014/10/10/
PY - 2014
DA - 2014 Oct 10
SP - E2
EP - E7
VL - 134
KW - DNA
KW - 9007-49-2
KW - Index Medicus
KW - Genes, ras
KW - Animals
KW - Papilloma -- etiology
KW - Humans
KW - DNA -- metabolism
KW - Mutation
KW - Skin Neoplasms -- etiology
KW - Carcinogenesis
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Milestones+in+skin+carcinogenesis%3A+the+biology+of+multistage+carcinogenesis.&rft.au=Balmain%2C+Allan%3BYuspa%2C+Stuart+H&rft.aulast=Balmain&rft.aufirst=Allan&rft.date=2014-10-10&rft.volume=134&rft.issue=&rft.spage=E2&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=1523-1747&rft_id=info:doi/10.1038%2Fskinbio.2014.2
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2014-12-12
N1 - Date created - 2014-10-11
N1 - Date revised - 2017-01-14
N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1038/skinbio.2014.2
ER -
TY - JOUR
T1 - Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.
AN - 1561032680; 24566672
AB - Aggregation of disordered amyloidogenic peptides into oligomers is the causative agent of amyloid-related diseases. In solution, disordered protein states are characterized by heterogeneous ensembles. Among these, β-rich conformers self-assemble via a conformational selection mechanism to form energetically-favored cross-β structures, regardless of their precise sequences. These disordered peptides can also penetrate the membrane, and electrophysiological data indicate that they form ion-conducting channels. Based on these and additional data, including imaging and molecular dynamics simulations of a range of amyloid peptides, Alzheimer's amyloid-β (Aβ) peptide, its disease-related variants with point mutations and N-terminal truncated species, other amyloidogenic peptides, as well as a cytolytic peptide and a synthetic gel-forming peptide, we suggest that disordered amyloidogenic peptides can also present a common motif in the membrane. The motif consists of curved, moon-like β-rich oligomers associated into annular organizations. The motif is favored in the lipid bilayer since it permits hydrophobic side chains to face and interact with the membrane and the charged/polar residues to face the solvated channel pores. Such channels are toxic since their pores allow uncontrolled leakage of ions into/out of the cell, destabilizing cellular ionic homeostasis. Here we detail Aβ, whose aggregation is associated with Alzheimer's disease (AD) and for which there are the most abundant data. AD is a protein misfolding disease characterized by a build-up of Aβ peptide as senile plaques, neurodegeneration, and memory loss. Excessively produced Aβ peptides may directly induce cellular toxicity, even without the involvement of membrane receptors through Aβ peptide-plasma membrane interactions.
JF - Chemical Society reviews
AU - Jang, Hyunbum
AU - Arce, Fernando Teran
AU - Ramachandran, Srinivasan
AU - Kagan, Bruce L
AU - Lal, Ratnesh
AU - Nussinov, Ruth
AD - Cancer and Inflammation Program, National Cancer Institute at Frederick, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA. jangh2@mail.nih.gov nussinor@helix.nih.gov.
Y1 - 2014/10/07/
PY - 2014
DA - 2014 Oct 07
SP - 6750
EP - 6764
VL - 43
IS - 19
KW - Amyloid beta-Peptides
KW - 0
KW - Lipid Bilayers
KW - Index Medicus
KW - Hydrophobic and Hydrophilic Interactions
KW - Humans
KW - Lipid Bilayers -- chemistry
KW - Molecular Dynamics Simulation
KW - Alzheimer Disease -- metabolism
KW - Protein Structure, Tertiary
KW - Lipid Bilayers -- metabolism
KW - Alzheimer Disease -- pathology
KW - Amyloid beta-Peptides -- metabolism
KW - Amyloid beta-Peptides -- chemistry
KW - Cell Membrane -- chemistry
KW - Cell Membrane -- metabolism
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L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Society+reviews&rft.atitle=Disordered+amyloidogenic+peptides+may+insert+into+the+membrane+and+assemble+into+common+cyclic+structural+motifs.&rft.au=Jang%2C+Hyunbum%3BArce%2C+Fernando+Teran%3BRamachandran%2C+Srinivasan%3BKagan%2C+Bruce+L%3BLal%2C+Ratnesh%3BNussinov%2C+Ruth&rft.aulast=Jang&rft.aufirst=Hyunbum&rft.date=2014-10-07&rft.volume=43&rft.issue=19&rft.spage=6750&rft.isbn=&rft.btitle=&rft.title=Chemical+Society+reviews&rft.issn=1460-4744&rft_id=info:doi/10.1039%2Fc3cs60459d
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-05-14
N1 - Date created - 2014-09-08
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1039/c3cs60459d
ER -
TY - JOUR
T1 - Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.
AN - 1561967224; 25193297
AB - The neoclerodane diterpenoid salvinorin A is a major secondary metabolite isolated from the psychoactive plant Salvia divinorum. Salvinorin A has been shown to have high affinity and selectivity for the κ-opioid receptor (KOR). To study the ligand-receptor interactions that occur between salvinorin A and the KOR, a new series of salvinorin A derivatives bearing potentially reactive Michael acceptor functional groups at C-2 was synthesized and used to probe the salvinorin A binding site. The κ-, δ-, and μ-opioid receptor (KOR, DOR and MOR, respectively) binding affinities and KOR efficacies were measured for the new compounds. Although none showed wash-resistant irreversible binding, most of them showed high affinity for the KOR, and some exhibited dual affinity to KOR and MOR. Molecular modeling techniques based on the recently-determined crystal structure of the KOR combined with results from mutagenesis studies, competitive binding, functional assays and structure-activity relationships, and previous salvinorin A-KOR interaction models were used to identify putative interaction modes of the new compounds with the KOR and MOR.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
JF - European journal of medicinal chemistry
AU - Polepally, Prabhakar R
AU - Huben, Krzysztof
AU - Vardy, Eyal
AU - Setola, Vincent
AU - Mosier, Philip D
AU - Roth, Bryan L
AU - Zjawiony, Jordan K
AD - Department of BioMolecular Sciences, Division of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA. ; Department of BioMolecular Sciences, Division of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA; Institute of Organic Chemistry, Technical University of Lodz, 90-924 Lodz, Poland. ; Department of Pharmacology, Division of Chemical Biology and Medicinal Chemistry, Medical School, NIMH Psychoactive Drug Screening Program, University of North Carolina, Chapel Hill, NC 27599, USA. ; Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA 23298-0540, USA. ; Department of BioMolecular Sciences, Division of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA. Electronic address: jordan@olemiss.edu.
Y1 - 2014/10/06/
PY - 2014
DA - 2014 Oct 06
SP - 818
EP - 829
VL - 85
KW - Diterpenes, Clerodane
KW - 0
KW - Ligands
KW - Receptors, Opioid, kappa
KW - salvinorin A
KW - T56W91NG6J
KW - Index Medicus
KW - Kappa, delta, and mu opioid receptors
KW - Salvinorin A and B
KW - Michael acceptor-type ligands
KW - Molecular modeling
KW - Models, Molecular
KW - Humans
KW - HEK293 Cells
KW - Protein Binding
KW - Protein Conformation
KW - Diterpenes, Clerodane -- metabolism
KW - Diterpenes, Clerodane -- chemical synthesis
KW - Receptors, Opioid, kappa -- metabolism
KW - Diterpenes, Clerodane -- chemistry
KW - Receptors, Opioid, kappa -- chemistry
KW - Drug Design
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561967224?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+medicinal+chemistry&rft.atitle=Michael+acceptor+approach+to+the+design+of+new+salvinorin+A-based+high+affinity+ligands+for+the+kappa-opioid+receptor.&rft.au=Polepally%2C+Prabhakar+R%3BHuben%2C+Krzysztof%3BVardy%2C+Eyal%3BSetola%2C+Vincent%3BMosier%2C+Philip+D%3BRoth%2C+Bryan+L%3BZjawiony%2C+Jordan+K&rft.aulast=Polepally&rft.aufirst=Prabhakar&rft.date=2014-10-06&rft.volume=85&rft.issue=&rft.spage=818&rft.isbn=&rft.btitle=&rft.title=European+journal+of+medicinal+chemistry&rft.issn=1768-3254&rft_id=info:doi/10.1016%2Fj.ejmech.2014.07.077
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-06-02
N1 - Date created - 2014-09-11
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.ejmech.2014.07.077
ER -
TY - JOUR
T1 - Cisplatin in cancer therapy: molecular mechanisms of action.
AN - 1609507628; 25058905
AB - Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinomas, germ cell tumors, lymphomas, and sarcomas. Its mode of action has been linked to its ability to crosslink with the purine bases on the DNA; interfering with DNA repair mechanisms, causing DNA damage, and subsequently inducing apoptosis in cancer cells. However, because of drug resistance and numerous undesirable side effects such as severe kidney problems, allergic reactions, decrease immunity to infections, gastrointestinal disorders, hemorrhage, and hearing loss especially in younger patients, other platinum-containing anti-cancer drugs such as carboplatin, oxaliplatin and others, have also been used. Furthermore, combination therapies of cisplatin with other drugs have been highly considered to overcome drug-resistance and reduce toxicity. This comprehensive review highlights the physicochemical properties of cisplatin and related platinum-based drugs, and discusses its uses (either alone or in combination with other drugs) for the treatment of various human cancers. A special attention is paid to its molecular mechanisms of action, and its undesirable side effects.
Copyright © 2014 Elsevier B.V. All rights reserved.
JF - European journal of pharmacology
AU - Dasari, Shaloam
AU - Tchounwou, Paul Bernard
AD - Cellomics and Toxicogenomics Research Laboratory, NIH/NIMHD RCMI-Center for Environmental Health, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, Box 18750, Jackson, MS 39217, USA. ; Cellomics and Toxicogenomics Research Laboratory, NIH/NIMHD RCMI-Center for Environmental Health, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, Box 18750, Jackson, MS 39217, USA. Electronic address: paul.b.tchounwou@jsums.edu.
Y1 - 2014/10/05/
PY - 2014
DA - 2014 Oct 05
SP - 364
EP - 378
VL - 740
KW - Antineoplastic Agents
KW - 0
KW - Cisplatin
KW - Q20Q21Q62J
KW - Index Medicus
KW - Platinum-based drugs
KW - Mechanisms of action
KW - Cancer treatment
KW - Drug Therapy, Combination
KW - Animals
KW - Humans
KW - Neoplasms -- drug therapy
KW - Cisplatin -- therapeutic use
KW - Cisplatin -- pharmacology
KW - Cisplatin -- adverse effects
KW - Antineoplastic Agents -- therapeutic use
KW - Antineoplastic Agents -- pharmacology
KW - Neoplasms -- metabolism
KW - Antineoplastic Agents -- adverse effects
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1609507628?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Cisplatin+in+cancer+therapy%3A+molecular+mechanisms+of+action.&rft.au=Dasari%2C+Shaloam%3BTchounwou%2C+Paul+Bernard&rft.aulast=Dasari&rft.aufirst=Shaloam&rft.date=2014-10-05&rft.volume=740&rft.issue=&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=1879-0712&rft_id=info:doi/10.1016%2Fj.ejphar.2014.07.025
LA - English
DB - ProQuest Environmental Science Collection
N1 - Date completed - 2015-10-30
N1 - Date created - 2014-08-27
N1 - Date revised - 2017-01-14
N1 - SuppNotes - Cited By:
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N1 - Last updated - 2017-01-19
DO - http://dx.doi.org/10.1016/j.ejphar.2014.07.025
ER -
TY - JOUR
T1 - The Role of Acculturation and Collectivism in Cancer Screening for Vietnamese American Women
AN - 1660021242; 201507973
AB - The aim of this study was to examine the influence of demographic variables and the interplay between collectivism and acculturation on breast and cervical cancer screening outcomes among Vietnamese American women. Convenience sampling was used to recruit 111 Vietnamese women from the Richmond, VA, metropolitan area, who participated in a larger cancer screening intervention. All participants completed measures on demographic variables, collectivism, acculturation, and cancer-screening-related variables (i.e., attitudes, self-efficacy, and screening behavior). Findings indicated that collectivism predicted both positive attitudes and higher levels of self-efficacy with regard to breast and cervical cancer screening. Collectivism also moderated the relationship between acculturation and attitudes toward breast cancer screening such that for women with low levels of collectivistic orientation, increasing acculturation predicted less positive attitudes towards breast cancer screening. This relationship was not found for women with high levels of collectivistic orientation. The current findings highlight the important roles that sociodemographic and cultural variables play in affecting health attitudes, self-efficacy, and behavior among Vietnamese women. The findings potentially inform screening programs that rely on culturally relevant values in helping increase Vietnamese women's motivation to screen. Adapted from the source document.
JF - Health Care for Women International
AU - Nguyen, Anh B
AU - Clark, Trenette T
AD - Division of Cancer Control and Population Sciences, The National Cancer Institute, Rockville, Maryland, USA
Y1 - 2014/10/03/
PY - 2014
DA - 2014 Oct 03
SP - 1162
EP - 1180
PB - Taylor & Francis, Philadelphia PA
VL - 35
IS - 10
SN - 0739-9332, 0739-9332
KW - Attitudes
KW - Acculturation
KW - Collectivism
KW - Tests
KW - Breast Cancer
KW - Asian Americans
KW - Empowerment
KW - Females
KW - Sociodemographic Factors
KW - article
KW - 2045: sociology of health and medicine; sociology of medicine & health care
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660021242?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Care+for+Women+International&rft.atitle=The+Role+of+Acculturation+and+Collectivism+in+Cancer+Screening+for+Vietnamese+American+Women&rft.au=Nguyen%2C+Anh+B%3BClark%2C+Trenette+T&rft.aulast=Nguyen&rft.aufirst=Anh&rft.date=2014-10-03&rft.volume=35&rft.issue=10&rft.spage=1162&rft.isbn=&rft.btitle=&rft.title=Health+Care+for+Women+International&rft.issn=07399332&rft_id=info:doi/10.1080%2F07399332.2013.863317
LA - English
DB - Sociological Abstracts
N1 - Date revised - 2015-03-01
N1 - Last updated - 2016-09-28
N1 - CODEN - HCWIDQ
N1 - SubjectsTermNotLitGenreText - Tests; Females; Acculturation; Collectivism; Attitudes; Breast Cancer; Empowerment; Sociodemographic Factors; Asian Americans
DO - http://dx.doi.org/10.1080/07399332.2013.863317
ER -
TY - JOUR
T1 - Evaluating the NIH Library Editing Service: Pilot Study Used to Analyze Service Impact
AN - 1667947080; 201503151
AB - Evidence-based librarianship drives initiatives and priorities in today's research centers. To evaluate the effectiveness of the National Institutes of Health (NIH) Library's Editing Service, librarians conducted a pilot study comparing edited manuscripts with the published versions. Using a random number generator, five published journal articles were chosen for evaluation from a pool of NIH manuscripts (n = 147) edited between January 2008 and February 2012. A rubric delineating categories of frequently checked writing elements was used to facilitate quantitative analysis. Findings showed that 84 percent of editors' suggestions were accepted for three of the published papers that were submitted to the originally intended journal. Adapted from the source document.
JF - Science & Technology Libraries
AU - Clark, Cindy
AU - Sullivan, Brigit
AD - National Institutes of Health (NIH) Library, Bethesda, Maryland
Y1 - 2014/10/02/
PY - 2014
DA - 2014 Oct 02
SP - 351
EP - 357
PB - Taylor & Francis, Philadelphia PA
VL - 33
IS - 4
SN - 0194-262X, 0194-262X
KW - Evaluation
KW - Scholarly publishing
KW - National libraries
KW - Medicine
KW - Editing
KW - article
KW - 4.15: USER SERVICES
UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667947080?accountid=14244
L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%26+Technology+Libraries&rft.atitle=Evaluating+the+NIH+Library+Editing+Service%3A+Pilot+Study+Used+to+Analyze+Service+Impact&rft.au=Clark%2C+Cindy%3BSullivan%2C+Brigit&rft.aulast=Clark&rft.aufirst=Cindy&rft.date=2014-10-02&rft.volume=33&rft.issue=4&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Science+%26+Technology+Libraries&rft.issn=0194262X&rft_id=info:doi/10.1080%2F0194262X.2014.950000
LA - English
DB - Library & Information Science Abstracts (LISA)
N1 - Date revised - 2015-06-01
N1 - Last updated - 2016-09-27
N1 - SubjectsTermNotLitGenreText - Evaluation; National libraries; Medicine; Editing; Scholarly publishing
DO - http://dx.doi.org/10.1080/0194262X.2014.950000
ER -