TY - JOUR T1 - Non-invasive detection of superimposed latent fingerprints and inter-ridge trace evidence by infrared spectroscopic imaging AN - 753633742; 13323978 AB - Current latent print and trace evidence collecting technologies are usually invasive and can be destructive to the original deposits. We describe a non-invasive vibrational spectroscopic approach that yields latent fingerprints that are overlaid on top of one another or that may contain trace evidence that needs to be distinguished from the print. Because of the variation in the chemical composition distribution within the fingerprint, we demonstrate that linear unmixing applied to the spectral content of the data can be used to provide images that reveal superimposed fingerprints. In addition, we demonstrate that the chemical composition of the trace evidence located in the region of the print can potentially be identified by its infrared spectrum. Thus, trace evidence found at a crime scene that previously could not be directly related to an individual, now has the potential to be directly related by its presence in the individual-identifying fingerprints. JF - Analytical and Bioanalytical Chemistry AU - Bhargava, Rohit AU - Perlman, Rebecca Schwartz AU - Fernandez, Daniel C AU - Levin, Ira W AU - Bartick, Edward G AD - Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, MD 20892-0520, USA, ebartick@suffolk.edu PY - 2009 SP - 2069 EP - 2075 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 394 IS - 8 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Yield KW - Chemical Composition KW - AQ 00001:Water Resources and Supplies KW - SW 5010:Network design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753633742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Non-invasive+detection+of+superimposed+latent+fingerprints+and+inter-ridge+trace+evidence+by+infrared+spectroscopic+imaging&rft.au=Bhargava%2C+Rohit%3BPerlman%2C+Rebecca+Schwartz%3BFernandez%2C+Daniel+C%3BLevin%2C+Ira+W%3BBartick%2C+Edward+G&rft.aulast=Bhargava&rft.aufirst=Rohit&rft.date=2009-08-01&rft.volume=394&rft.issue=8&rft.spage=2069&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-009-2817-6 L2 - http://www.springerlink.com/content/u27k87r4057641p7/?p=0801e41a85d04901a36bcb9150a18efc&pi=9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Yield; Chemical Composition DO - http://dx.doi.org/10.1007/s00216-009-2817-6 ER - TY - JOUR T1 - Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase AN - 753632581; 13323961 AB - Alpha-galactosidase A hydrolyzes the terminal alpha-galactosyl moieties from glycolipids and glycoproteins in lysosomes. Mutations in *a-galactosidase cause lysosomal accumulation of the glycosphingolipid, globotriaosylceramide, which leads to Fabry disease. Small-molecule chaperones that bind to mutant enzyme proteins and correct their misfolding and mistrafficking have emerged as a potential therapy for Fabry disease. We have synthesized a red fluorogenic substrate, resorufinyl *a-d-galactopyranoside, for a new *a-galactosidase enzyme assay. This assay can be measured continuously at lower pH values, without the addition of a stop solution, due to the relatively low pK a of resorufin (~6). In addition, the assay emits red fluorescence, which can significantly reduce interferences due to compound fluorescence and dust/lint as compared to blue fluorescence. Therefore, this new red fluorogenic substrate and the resulting enzyme assay can be used in high-throughput screening to identify small-molecule chaperones for Fabry disease. JF - Analytical and Bioanalytical Chemistry AU - Shi, Zhen-Dan AU - Motabar, Omid AU - Goldin, Ehud AU - Liu, Ke AU - Southall, Noel AU - Sidransky, Ellen AU - Austin, Christopher P AU - Griffiths, Gary L AU - Zheng, Wei AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA, wzheng@mail.nih.gov PY - 2009 SP - 1903 EP - 1909 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 394 IS - 7 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Fluorescence KW - Enzymes KW - Dusts KW - Assay KW - Substrates KW - Proteins KW - Diseases KW - Synthesis KW - Accumulation KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753632581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Synthesis+and+characterization+of+a+new+fluorogenic+substrate+for+alpha-galactosidase&rft.au=Shi%2C+Zhen-Dan%3BMotabar%2C+Omid%3BGoldin%2C+Ehud%3BLiu%2C+Ke%3BSouthall%2C+Noel%3BSidransky%2C+Ellen%3BAustin%2C+Christopher+P%3BGriffiths%2C+Gary+L%3BZheng%2C+Wei&rft.aulast=Shi&rft.aufirst=Zhen-Dan&rft.date=2009-08-01&rft.volume=394&rft.issue=7&rft.spage=1903&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-009-2879-5 L2 - http://www.springerlink.com/content/v0lh5750r728l684/?p=a01c65e49a244689895b3172d07b3153&pi=20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Fluorescence; Substrates; Assay; Proteins; Enzymes; Diseases; Synthesis; Accumulation; Dusts DO - http://dx.doi.org/10.1007/s00216-009-2879-5 ER - TY - JOUR T1 - Early neuropsychological signs of childhood adrenoleukodystrophy (ALD). AN - 742782295; pmid-19497692 AB - OBJECTIVE: To identify the very early signs of childhood cerebral adrenoleukodystrophy (CALD) in asymptomatic boys. Methods: Subjects were 8 neurologically and radiologically asymptomatic CALD patients. They were chosen from 22 ALD patients before hematopoietic stem cell transplantation (HSCT) treatment. Wechsler Intelligence Scale tests and other neuropsychological tests were performed. Their IQ data were compared with those of symptomatic ALD children with apparent brain lesions. RESULTS: All asymptomatic CALD showed normal FIQ. PIQ was significantly lower than VIQ in 2 patients. Occipital lesioned patients often showed normal VIQ with low PIQ. Gestalt Closure in The Kaufman Assessment Battery for Children and Constancy of Shape in the Frostig Developmental Test of Visual Perception seemed to be effective for detecting visual cognitive dysfunction in asymptomatic CALD whose difference of VIQ and PIQ was within the normal range. CONCLUSIONS: Follow-up of asymptomatic ALD boys with neuropsychological tests along with previously reported neurophysiological tests may help in determining the timing of therapeutic intervention. Neuropsychological abnormalities seemed to precede the appearance of clinical and MRI alterations. JF - Brain & development AU - Kaga, Makiko AU - Furushima, Wakana AU - Inagaki, Masumi AU - Nakamura, Masako AD - Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8553, Japan. kaga@ncnp.go.jp Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 558 EP - 561 VL - 31 IS - 7 SN - 0387-7604, 0387-7604 KW - Index Medicus KW - National Library of Medicine KW - Magnetic Resonance Imaging KW - Humans KW - Child KW - Child, Preschool KW - Brain -- physiopathology KW - Evoked Potentials, Visual KW - Brain -- pathology KW - Hematopoietic Stem Cell Transplantation KW - Adolescent KW - Neuropsychological Tests KW - Early Diagnosis KW - Male KW - Intelligence Tests KW - Adrenoleukodystrophy -- pathology KW - Adrenoleukodystrophy -- therapy KW - Adrenoleukodystrophy -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742782295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+%26+development&rft.atitle=Early+neuropsychological+signs+of+childhood+adrenoleukodystrophy+%28ALD%29.&rft.au=Kaga%2C+Makiko%3BFurushima%2C+Wakana%3BInagaki%2C+Masumi%3BNakamura%2C+Masako&rft.aulast=Kaga&rft.aufirst=Makiko&rft.date=2009-08-01&rft.volume=31&rft.issue=7&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=Brain+%26+development&rft.issn=03877604&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Cutaneous pigmentation after photosensitivity induced by vandetanib therapy. AN - 67586952; 19687425 AB - Photosensitivity has been reported in patients who were treated with vandetanib (ZD6474), an inhibitor of epidermal growth factor receptor, vascular endothelial growth factor receptor, and the RET (rearranged during transfection) kinases. We describe the occurrence of cutaneous hyperpigmentation after photosensitivity in 2 patients who were treated with vandetanib. The pigmentation patterns were variable within and between patients. Biopsy specimens from different sites revealed variability in Perls and Fontana staining patterns. These 2 cases highlight the unusual occurrence of cutaneous hyperpigmentation after vandetanib-associated photosensitivity, a reaction that demonstrates that medications are important causes of acquired photosensitivity and hyperpigmentation. Aggressive photoprotection may facilitate the resolution of diffuse hyperpigmentation. Dermatologists should endeavor to identify and report novel cutaneous adverse effects as new targeted therapies are developed. JF - Archives of dermatology AU - Kong, Heidi H AU - Fine, Howard A AU - Stern, Jere B AU - Turner, Maria L Chanco AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bldg 10, Room 12N238, 10 Center Dr, Bethesda, MD 20892, USA. konghe@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 923 EP - 925 VL - 145 IS - 8 KW - Antineoplastic Agents KW - 0 KW - Piperidines KW - Quinazolines KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Receptors, Vascular Endothelial Growth Factor KW - N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine KW - YO460OQ37K KW - Abridged Index Medicus KW - Index Medicus KW - Protein-Tyrosine Kinases -- antagonists & inhibitors KW - Receptors, Vascular Endothelial Growth Factor -- antagonists & inhibitors KW - Hyperpigmentation -- pathology KW - Humans KW - Skin -- pathology KW - Aged KW - Middle Aged KW - Hyperpigmentation -- chemically induced KW - Female KW - Piperidines -- therapeutic use KW - Quinazolines -- therapeutic use KW - Dermatitis, Phototoxic -- etiology KW - Quinazolines -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Piperidines -- adverse effects KW - Dermatitis, Phototoxic -- pathology KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67586952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=Cutaneous+pigmentation+after+photosensitivity+induced+by+vandetanib+therapy.&rft.au=Kong%2C+Heidi+H%3BFine%2C+Howard+A%3BStern%2C+Jere+B%3BTurner%2C+Maria+L+Chanco&rft.aulast=Kong&rft.aufirst=Heidi&rft.date=2009-08-01&rft.volume=145&rft.issue=8&rft.spage=923&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=1538-3652&rft_id=info:doi/10.1001%2Farchdermatol.2009.177 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-01 N1 - Date created - 2009-08-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Clin Dermatol. 2001;2(4):253-62 [11705252] Lancet Oncol. 2005 Jul;6(7):491-500 [15992698] J Thorac Oncol. 2008 Apr;3(4):386-93 [18379357] J Thorac Oncol. 2006 Nov;1(9):1002-9 [17409986] J Clin Oncol. 2007 Sep 20;25(27):4270-7 [17878479] J Surg Res. 2005 Dec;129(2):251-9 [16140331] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1001/archdermatol.2009.177 ER - TY - JOUR T1 - Metastatic phyllodes tumor causing small-bowel obstruction. AN - 67561517; 19661046 AB - Cystosarcoma phyllodes is an important but relatively uncommon fibroepithelial breast neoplasm that accounts for 0.5%-1.0% of female breast carcinomas. Malignant forms comprise nearly 25% of cases. These usually metastasize to the lung, pleura, bone, and liver. Metastases to the small intestine are extremely rare, with only 1 case of metastatic spread to the duodenum reported in the literature. No previous reports of metastatic spread to the ileum have been published. This report highlights a unique case of a metastatic phyllodes breast tumor leading to small bowel obstruction. Phyllodes tumors are generally classified into histologic subtypes of benign, intermediate, and malignant, using agreed classification systems. The tumor characteristics that can lead to the dedifferentiation of a relatively benign phenotype to an overt malignant process are discussed. Chemotherapeutic regimens that might be effective treatments are discussed, and the importance of regular clinical and radiologic follow-up in patients with poor prognostic factors is outlined. JF - Clinical breast cancer AU - Kelly, Ronan J AU - Barrett, Ciara AU - Swan, Niall AU - McDermott, Ray AD - National Cancer Institute, Bethesda, MD 20892, USA. kellyro@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 193 EP - 195 VL - 9 IS - 3 KW - Antibiotics, Antineoplastic KW - 0 KW - Antineoplastic Agents, Alkylating KW - Doxorubicin KW - 80168379AG KW - Ifosfamide KW - UM20QQM95Y KW - Index Medicus KW - Antibiotics, Antineoplastic -- administration & dosage KW - Combined Modality Therapy KW - Humans KW - Middle Aged KW - Mastectomy KW - Doxorubicin -- administration & dosage KW - Antineoplastic Agents, Alkylating -- administration & dosage KW - Neoplasm Recurrence, Local KW - Female KW - Ifosfamide -- administration & dosage KW - Phyllodes Tumor -- therapy KW - Ileal Neoplasms -- secondary KW - Intestinal Obstruction -- etiology KW - Phyllodes Tumor -- complications KW - Breast Neoplasms -- pathology KW - Breast Neoplasms -- therapy KW - Phyllodes Tumor -- pathology KW - Breast Neoplasms -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67561517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Epigenetic+Basis+of+Neurodevelopmental+Disorders+%28X2%29&rft.atitle=Genetics+and+Brain+Development+of+Childhood+Onset+Schizophrenia%3A+Update+2009&rft.au=Rapoport%2C+Judith&rft.aulast=Rapoport&rft.aufirst=Judith&rft.date=2009-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Epigenetic+Basis+of+Neurodevelopmental+Disorders+%28X2%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-09 N1 - Date created - 2009-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3816/CBC.2009.n.033 ER - TY - JOUR T1 - The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. AN - 67558703; 19493248 AB - Telomeres consist of nucleotide repeats and a protein complex at chromosome ends that are essential to maintaining chromosomal integrity. Several studies have suggested that subjects with shorter telomeres are at increased risk of bladder and lung cancer. In comparison to normal tissues, telomeres are shorter in high-grade intraepithelial neoplasia and prostate cancer. We examined prostate cancer risk associated with relative telomere length as determined by quantitative PCR on prediagnostic buffy coat DNA isolated from 612 advanced prostate cancer cases and 1049 age-matched, cancer-free controls from the PLCO Cancer Screening Trial. Telomere length was analyzed as both a continuous and a categorical variable with adjustment for potential confounders. Statistically significant inverse correlations between telomere length, age and smoking status were observed in cases and controls. Telomere length was not associated with prostate cancer risk (at the median, OR = 0.85, 95% CI: 0.67, 1.08); associations were similar when telomere length was evaluated as a continuous variable or by quartiles. The relationships between telomere length and inflammation-related factors, diet, exercise, body mass index, and other lifestyle variables were explored since many of these have previously been associated with shorter telomeres. Healthy lifestyle factors (i.e., lower BMI, more exercise, tobacco abstinence, diets high in fruit and vegetables) tended to be associated with greater telomere length. This study found no statistically significant association between leukocyte telomere length and advanced prostate cancer risk. However, correlations of telomere length with healthy lifestyles were noted, suggesting the role of these factors in telomere biology maintenance and potentially impacting overall health status. JF - Aging cell AU - Mirabello, Lisa AU - Huang, Wen-Yi AU - Wong, Jason Y Y AU - Chatterjee, Nilanjan AU - Reding, Douglas AU - Crawford, E David AU - De Vivo, Immaculata AU - Hayes, Richard B AU - Savage, Sharon A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 405 EP - 413 VL - 8 IS - 4 KW - Index Medicus KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Life Style KW - Prostatic Neoplasms -- epidemiology KW - Telomere KW - Leukocytes KW - Prostatic Neoplasms -- chemically induced KW - Smoking -- adverse effects KW - Prostatic Neoplasms -- genetics KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67558703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+cell&rft.atitle=The+association+between+leukocyte+telomere+length+and+cigarette+smoking%2C+dietary+and+physical+variables%2C+and+risk+of+prostate+cancer.&rft.au=Mirabello%2C+Lisa%3BHuang%2C+Wen-Yi%3BWong%2C+Jason+Y+Y%3BChatterjee%2C+Nilanjan%3BReding%2C+Douglas%3BCrawford%2C+E+David%3BDe+Vivo%2C+Immaculata%3BHayes%2C+Richard+B%3BSavage%2C+Sharon+A&rft.aulast=Mirabello&rft.aufirst=Lisa&rft.date=2009-08-01&rft.volume=8&rft.issue=4&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Aging+cell&rft.issn=1474-9726&rft_id=info:doi/10.1111%2Fj.1474-9726.2009.00485.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-26 N1 - Date created - 2009-08-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2002 May 15;30(10):e47 [12000852] Trends Biochem Sci. 2002 Jul;27(7):339-44 [12114022] Am J Epidemiol. 2002 Aug 1;156(3):274-85 [12142263] Science. 2002 Jul 26;297(5581):565-9 [12142527] Diabetes Care. 2006 Feb;29(2):283-9 [16443874] Epidemiology. 2006 Mar;17(2):190-4 [16477260] Cytogenet Genome Res. 2006;112(3-4):194-201 [16484772] Eur Respir J. 2006 Mar;27(3):525-8 [16507852] Int J Cancer. 2006 Oct 1;119(7):1690-4 [16646073] Neurosci Lett. 2006 Oct 9;406(3):260-4 [16919874] Aging Cell. 2006 Oct;5(5):361-5 [16856882] Neoplasia. 2007 Jan;9(1):81-9 [17325746] J Urol. 2007 Apr;177(4):1395-400; quiz 1591 [17382740] Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):815-9 [17416776] Nat Genet. 2007 May;39(5):645-9 [17401363] Front Biosci. 2007;12:4595-620 [17485399] Indian J Med Res. 2007 Mar;125(3):441-50 [17496367] Cancer Res. 2007 Jun 1;67(11):5538-44 [17545637] Chronic Dis Can. 2007;27(4):145-53 [17623560] J Urol. 2007 Oct;178(4 Pt 1):1492-6 [17707063] Aging Cell. 2007 Oct;6(5):639-47 [17874998] Am J Clin Nutr. 2007 Nov;86(5):1420-5 [17991655] Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2649-55 [18086770] Free Radic Biol Med. 2008 Feb 1;44(3):235-46 [18021748] Arch Intern Med. 2008 Jan 28;168(2):154-8 [18227361] Mov Disord. 2008 Jan 30;23(2):302-5 [18044760] J Hum Hypertens. 2008 Mar;22(3):230-2 [18046431] Nat Genet. 2008 Mar;40(3):310-5 [18264096] Nat Genet. 2008 Mar;40(3):316-21 [18264097] Circulation. 2008 Mar 4;117(9):1138-44 [18268147] Physiol Rev. 2008 Apr;88(2):557-79 [18391173] Cancer Res. 2008 May 15;68(10):3618-23 [18483243] Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1165-71 [18388332] Cancer Sci. 2008 Jul;99(7):1385-9 [18452563] J Natl Cancer Inst. 2008 Jun 4;100(11):796-804 [18505967] Acta Paediatr. 2008 Jul;97(7):952-4 [18430074] Mutat Res. 2008 Jul-Aug;659(1-2):15-30 [18485806] Curr Urol Rep. 2008 May;9(3):243-9 [18765120] Toxicology. 2002 Nov 15;180(2):121-37 [12324189] Cancer Res. 2002 Nov 15;62(22):6405-9 [12438224] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Hum Mol Genet. 2003 Feb 1;12(3):227-32 [12554677] Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):434-9 [12615693] J Natl Cancer Inst. 2003 Aug 20;95(16):1211-8 [12928346] Lancet. 2003 Sep 20;362(9388):983-8 [14511933] Lancet. 2004 Feb 14;363(9408):507-10 [14975611] Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R103-21 [14749351] Circ Res. 2004 Mar 19;94(5):575-84 [15031270] Oncogene. 2004 Apr 12;23(16):2919-33 [15077154] Eur J Cancer. 1997 Apr;33(5):787-91 [9282118] Cell. 1997 Oct 3;91(1):25-34 [9335332] Diabetes. 1998 Mar;47(3):482-6 [9519758] Cell. 1999 Mar 5;96(5):701-12 [10089885] J Urol. 1999 Nov;162(5):1788-92 [10524936] J Urol. 2005 Feb;173(2):610-4 [15643274] Int J Biochem Cell Biol. 2005 May;37(5):1000-13 [15743674] Circulation. 2005 May 3;111(17):2171-7 [15851602] Carcinogenesis. 2005 Jul;26(7):1263-71 [15746160] Lancet. 2005 Aug 20-26;366(9486):662-4 [16112303] Future Oncol. 2008 Oct;4(5):637-45 [18922121] Lancet Oncol. 2008 Nov;9(11):1048-57 [18799354] Am J Epidemiol. 2009 Feb 1;169(3):323-9 [19056834] Genes Dev. 2005 Sep 15;19(18):2100-10 [16166375] Exp Cell Res. 2000 May 1;256(2):578-82 [10772830] Nature. 2000 Aug 10;406(6796):641-5 [10949306] Control Clin Trials. 2000 Dec;21(6 Suppl):251S-272S [11189683] Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684] Oncogene. 2002 Jan 21;21(4):564-79 [11850781] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1474-9726.2009.00485.x ER - TY - JOUR T1 - Using sickness absence records to predict future depression in a working population: prospective findings from the GAZEL cohort. AN - 67470124; 19542039 AB - We tested the hypothesis that sickness absence from work predicts workers' risk of later depression. Study participants (n = 7391) belonged to the French GAZEL cohort of employees of the national gas and electricity company. Sickness absence data (1996-1999) were obtained from company records. Participants' depression in 1996 and 1999 was assessed with the Center for Epidemiologic Studies-Depression (CES-D) scale. The analyses were controlled for baseline age, gender, marital status, occupational grade, tobacco smoking status, alcohol consumption, subthreshold depressive symptoms, and work stress. Among workers who were free of depression in 1996, 13% had depression in 1999. Compared with workers with no sickness absence during the study period, those with sickness absence were more likely to be depressed at follow-up (for 1 period of sickness absence, fully adjusted odds ratio [OR] = 1.53, 95% confidence interval [CI] = 1.28, 1.82; for 2 or more periods, fully adjusted OR = 1.95, 95% CI = 1.61, 2.36). Future depression was predicted both by psychiatric and nonpsychiatric sickness absence (fully adjusted OR = 3.79 [95% CI = 2.81, 5.10] and 1.41 [95% CI = 1.21, 1.65], respectively). Sickness absence records may help identify workers vulnerable to future depression. JF - American journal of public health AU - Melchior, Maria AU - Ferrie, Jane E AU - Alexanderson, Kristina AU - Goldberg, Marcel AU - Kivimaki, Mika AU - Singh-Manoux, Archana AU - Vahtera, Jussi AU - Westerlund, Hugo AU - Zins, Marie AU - Head, Jenny AD - National Institutes of Health and Medical Research (INSERM U687), 94807 Villejuif Cédex, France. maria.melchior@inserm.fr Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 1417 EP - 1422 VL - 99 IS - 8 KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Humans KW - Health Status KW - Cohort Studies KW - Adult KW - France -- epidemiology KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Catchment Area (Health) KW - Substance-Related Disorders -- epidemiology KW - Employment -- statistics & numerical data KW - Employment -- psychology KW - Medical Records KW - Depression -- psychology KW - Depression -- epidemiology KW - Forecasting KW - Sick Leave -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67470124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Using+sickness+absence+records+to+predict+future+depression+in+a+working+population%3A+prospective+findings+from+the+GAZEL+cohort.&rft.au=Melchior%2C+Maria%3BFerrie%2C+Jane+E%3BAlexanderson%2C+Kristina%3BGoldberg%2C+Marcel%3BKivimaki%2C+Mika%3BSingh-Manoux%2C+Archana%3BVahtera%2C+Jussi%3BWesterlund%2C+Hugo%3BZins%2C+Marie%3BHead%2C+Jenny&rft.aulast=Melchior&rft.aufirst=Maria&rft.date=2009-08-01&rft.volume=99&rft.issue=8&rft.spage=1417&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=1541-0048&rft_id=info:doi/10.2105%2FAJPH.2008.142273 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-17 N1 - Date created - 2009-07-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 2001 Aug 15;154(4):373-84 [11495861] Occup Environ Med. 2008 Dec;65(12):820-6 [18611969] BMJ. 2003 Aug 16;327(7411):364 [12919985] J Epidemiol Community Health. 2004 Apr;58(4):321-6 [15026447] Scand J Public Health Suppl. 2004;63:3-263 [15513647] Scand J Public Health Suppl. 2004;63:207-15 [15513658] Soc Sci Med. 1995 Jan;40(2):189-97 [7899931] J Epidemiol Community Health. 1995 Apr;49(2):124-30 [7798038] Med Lav. 1996 Jan-Feb;87(1):16-28 [8699978] J Affect Disord. 1997 Aug;45(1-2):19-30 [9268772] Health Aff (Millwood). 1999 Sep-Oct;18(5):163-71 [10495604] J Rehabil Med. 2005 Sep;37(5):291-9 [16203618] Gen Hosp Psychiatry. 2006 May-Jun;28(3):223-9 [16675365] Am J Psychiatry. 2006 Aug;163(8):1412-8 [16877655] J Clin Epidemiol. 2006 Nov;59(11):1213-21 [17027433] Eur Psychiatry. 2006 Oct;21(7):451-9 [16675204] BMC Health Serv Res. 2007;7:29 [17326830] Neuroepidemiology. 2007;28(2):101-8 [17409771] Int J Epidemiol. 2007 Feb;36(1):32-9 [17101614] J Affect Disord. 2007 Jun;100(1-3):163-9 [17126913] Psychiatr Serv. 2007 Nov;58(11):1479-82 [17978260] J Clin Psychiatry. 2007 Dec;68(12):1886-93 [18162019] Eur J Public Health. 2008 Oct;18(5):517-21 [18332039] Int Arch Occup Environ Health. 2002 Mar;75(3):129-44 [11954980] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2105/AJPH.2008.142273 ER - TY - JOUR T1 - The Mi-2/NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells. AN - 67413867; 19296121 AB - Chromosomal replication results in the duplication not only of DNA sequence but also of the patterns of histone modification, DNA methylation, and nucleoprotein structure that constitute epigenetic information. Pericentromeric heterochromatin in human cells is characterized by unique patterns of histone and DNA modification. Here, we describe association of the Mi-2/NuRD complex with specific segments of pericentromeric heterochromatin consisting of Satellite II/III DNA located on human chromosomes 1, 9, and 16 in some but not all cell types. This association is linked in part to DNA replication and chromatin assembly and may suggest a role in these processes. Mi-2/NuRD accumulation is independent of Polycomb association and is characterized by a unique pattern of histone modification. We propose that Mi-2/NuRD constitutes an enzymatic component of a pathway for assembly and maturation of chromatin utilized by rapidly proliferating lymphoid cells for replication of constitutive heterochromatin. JF - Chromosoma AU - Helbling Chadwick, Lisa AU - Chadwick, Brian P AU - Jaye, David L AU - Wade, Paul A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 445 EP - 457 VL - 118 IS - 4 KW - Autoantigens KW - 0 KW - BMI1 protein, human KW - CHD4 protein, human KW - Heterochromatin KW - IKZF1 protein, human KW - Nuclear Proteins KW - Proliferating Cell Nuclear Antigen KW - Proto-Oncogene Proteins KW - Repressor Proteins KW - Ikaros Transcription Factor KW - 148971-36-2 KW - Polycomb Repressive Complex 1 KW - EC 2.3.2.27 KW - Histone Deacetylases KW - EC 3.5.1.98 KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Microscopy, Confocal KW - Centromere -- genetics KW - Cell Nucleus -- metabolism KW - Humans KW - Repressor Proteins -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - In Situ Hybridization, Fluorescence KW - Centromere -- metabolism KW - Cell Line, Tumor KW - Ikaros Transcription Factor -- metabolism KW - Cell Proliferation KW - Protein Binding KW - Nuclear Proteins -- metabolism KW - Fluorescent Antibody Technique KW - Immunohistochemistry KW - Proliferating Cell Nuclear Antigen -- metabolism KW - Cell Line KW - DNA Helicases -- metabolism KW - Heterochromatin -- metabolism KW - Histone Deacetylases -- metabolism KW - S Phase KW - Lymphocytes -- metabolism KW - Heterochromatin -- genetics KW - Autoantigens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67413867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chromosoma&rft.atitle=The+Mi-2%2FNuRD+complex+associates+with+pericentromeric+heterochromatin+during+S+phase+in+rapidly+proliferating+lymphoid+cells.&rft.au=Helbling+Chadwick%2C+Lisa%3BChadwick%2C+Brian+P%3BJaye%2C+David+L%3BWade%2C+Paul+A&rft.aulast=Helbling+Chadwick&rft.aufirst=Lisa&rft.date=2009-08-01&rft.volume=118&rft.issue=4&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Chromosoma&rft.issn=1432-0886&rft_id=info:doi/10.1007%2Fs00412-009-0207-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-02 N1 - Date created - 2009-06-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2001 Mar 1;410(6824):116-20 [11242053] Cytogenet Cell Genet. 2000;90(3-4):279-84 [11124534] Mol Cell Biol. 2002 Aug;22(15):5539-53 [12101246] J Cell Sci. 2002 Nov 1;115(Pt 21):4037-51 [12356909] Science. 2002 Nov 1;298(5595):1039-43 [12351676] Cell. 2003 Apr 18;113(2):207-19 [12705869] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):52-7 [15020045] Blood. 2004 Apr 1;103(7):2683-90 [14645008] EMBO J. 2004 Sep 1;23(17):3516-26 [15306854] Cell. 2004 Oct 1;119(1):75-86 [15454082] J Ultrastruct Res. 1969 May;27(3):266-88 [5813971] Intervirology. 1975;5(6):319-34 [181343] Cell. 1976 Dec;9(4 Pt 1):503-9 [1009572] Blood. 1986 Jun;67(6):1542-9 [2423157] Immunol Lett. 1988 Aug;18(4):297-9 [3263319] J Med Genet. 1989 Jul;26(7):452-6 [2746618] Nature. 1990 Feb 1;343(6257):437-41 [2137203] Cell. 1991 May 31;65(5):817-23 [1904010] J Cell Sci. 1991 Jun;99 ( Pt 2):247-53 [1885669] Eur J Immunol. 1991 Dec;21(12):2951-62 [1748148] J Cell Biol. 1992 Mar;116(5):1095-110 [1740468] Cytogenet Cell Genet. 1994;66(2):99-103 [8287692] Cell. 1994 Jan 28;76(2):345-56 [8293468] Chromosome Res. 1994 May;2(3):245-53 [8069468] Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1237-41 [7862667] Cancer. 1995 Oct 1;76(7):1238-44 [8630904] Cell. 1997 Dec 12;91(6):845-54 [9413993] Blood. 1998 Mar 1;91(5):1732-41 [9473240] Curr Biol. 1998 Jul 2;8(14):843-6 [9663395] J Cell Biol. 1998 Aug 24;142(4):887-98 [9722603] Mol Cell Biol. 1998 Nov;18(11):6538-47 [9774669] Cell. 1998 Oct 16;95(2):279-89 [9790534] Mol Cell. 1998 Dec;2(6):851-61 [9885572] Mol Cell. 1999 Feb;3(2):207-17 [10078203] Immunity. 1999 Mar;10(3):345-55 [10204490] Leukemia. 1999 May;13(5):671-8 [10374869] Mol Cell Biol. 1999 Sep;19(9):6415-26 [10454587] Nat Genet. 1999 Sep;23(1):62-6 [10471500] Lab Invest. 1964 Feb;13:95-104 [14161668] Curr Opin Genet Dev. 2006 Apr;16(2):104-11 [16504499] J Biol Chem. 2006 May 5;281(18):12760-6 [16517599] J Biol Chem. 2008 Jul 11;283(28):19478-88 [18480059] J Cell Sci. 1999 Dec;112 ( Pt 24):4627-39 [10574711] Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14412-7 [10588719] J Cell Biol. 1999 Dec 13;147(6):1153-66 [10601331] Leukemia. 1999 Dec;13(12):1975-81 [10602418] Nature. 1999 Nov 11;402(6758):187-91 [10647011] Mol Cell Biol. 2000 Feb;20(4):1394-406 [10648624] Biochemistry. 2000 May 9;39(18):5238-45 [10819992] Genes Dev. 2001 Apr 1;15(7):827-32 [11297506] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00412-009-0207-7 ER - TY - JOUR T1 - A cell-based high-throughput screen to identify synergistic TRAIL sensitizers. AN - 67292520; 19089423 AB - We have developed a high-throughput screen (HTS) to search for novel molecules that can synergize with TRAIL, thus promoting apoptosis of ACHN renal tumor cells in a combinatorial fashion. The HTS detects synthetic compounds and pure natural products that can pre-sensitize the cancer cells to TRAIL-mediated apoptosis, yet have limited toxicity on their own. We have taken into account the individual effects of the single agents, versus the combination, and have identified hits that are synergistic, synergistic-toxic, or additive when combined with TRAIL in promoting tumor cell death. Preliminary mechanistic studies indicate that a subset of the synergistic TRAIL sensitizers act very rapidly to promote cleavage and activation of caspase-8 following TRAIL binding. Caspase-8 is an apical enzyme that initiates programmed cell death via the extrinsic apoptotic pathway. Thus, these TRAIL sensitizers may potentially reduce resistance of tumor cells to TRAIL-mediated apoptosis. Two representative sensitizers were found to increase levels of p53 but did not inhibit the proteasome, suggesting that early DNA damage-sensing pathways may be involved in their mechanisms of action. JF - Cancer immunology, immunotherapy : CII AU - Booth, Nancy Lynn AU - Sayers, Thomas J AU - Brooks, Alan D AU - Thomas, Cheryl L AU - Jacobsen, Kristen AU - Goncharova, Ekaterina I AU - McMahon, James B AU - Henrich, Curtis J AD - Molecular Targets Development Program, Center for Cancer Research, NCI-Frederick, Frederick, MD 21702, USA. nancylynnbooth@gmail.com Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 1229 EP - 1244 VL - 58 IS - 8 KW - Antineoplastic Agents KW - 0 KW - TNF-Related Apoptosis-Inducing Ligand KW - Tumor Suppressor Protein p53 KW - Caspase 8 KW - EC 3.4.22.- KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Membrane Potential, Mitochondrial -- physiology KW - Drug Screening Assays, Antitumor KW - Membrane Potential, Mitochondrial -- drug effects KW - Apoptosis KW - Proteasome Endopeptidase Complex -- metabolism KW - Humans KW - Tumor Suppressor Protein p53 -- drug effects KW - Proteasome Endopeptidase Complex -- drug effects KW - Cell Line, Tumor KW - Drug Synergism KW - Tumor Suppressor Protein p53 -- metabolism KW - TNF-Related Apoptosis-Inducing Ligand -- pharmacology KW - Caspase 8 -- metabolism KW - Adenocarcinoma -- metabolism KW - Kidney Neoplasms -- metabolism KW - Antineoplastic Agents -- isolation & purification KW - Caspase 8 -- drug effects KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67292520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=A+cell-based+high-throughput+screen+to+identify+synergistic+TRAIL+sensitizers.&rft.au=Booth%2C+Nancy+Lynn%3BSayers%2C+Thomas+J%3BBrooks%2C+Alan+D%3BThomas%2C+Cheryl+L%3BJacobsen%2C+Kristen%3BGoncharova%2C+Ekaterina+I%3BMcMahon%2C+James+B%3BHenrich%2C+Curtis+J&rft.aulast=Booth&rft.aufirst=Nancy&rft.date=2009-08-01&rft.volume=58&rft.issue=8&rft.spage=1229&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=1432-0851&rft_id=info:doi/10.1007%2Fs00262-008-0637-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-12 N1 - Date created - 2009-05-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 2002 Mar 15;99(6):2162-71 [11877293] Nat Med. 2002 Aug;8(8):808-15 [12118245] J Biol Chem. 2002 Oct 4;277(40):37630-6 [12145284] Neoplasia. 2002 Nov-Dec;4(6):551-7 [12407450] Prostate. 2002 Dec 1;53(4):286-99 [12430140] Hepatology. 2002 Dec;36(6):1498-508 [12447876] Cell Death Differ. 2003 Jan;10(1):144-5 [12655304] Oncogene. 2003 Mar 27;22(12):1807-16 [12660816] Nat Immunol. 2003 May;4(5):404-9 [12719729] Blood. 2003 Jul 1;102(1):303-10 [12637321] Brain Pathol. 2003 Oct;13(4):539-53 [14655759] Mol Ther. 2004 May;9(5):666-73 [15120327] Cancer Res. 2004 May 15;64(10):3376-9 [15150087] Oncogene. 2004 Aug 19;23(37):6261-71 [15208660] J Antibiot (Tokyo). 1982 Aug;35(8):1033-7 [7142004] J Antibiot (Tokyo). 1983 Sep;36(9):1228-35 [6355040] Cancer Res. 1988 Sep 1;48(17):4827-33 [3409223] J Natl Cancer Inst. 1990 Jul 4;82(13):1107-12 [2359136] Proc Natl Acad Sci U S A. 1991 May 1;88(9):3671-5 [2023917] J Med Chem. 1991 Jul;34(7):2079-88 [2066979] Immunity. 1995 Dec;3(6):673-82 [8777713] J Biol Chem. 1996 May 31;271(22):12687-90 [8663110] Science. 1997 Apr 4;276(5309):111-3 [9082980] Science. 1997 Aug 8;277(5327):815-8 [9242610] Science. 1997 Aug 8;277(5327):818-21 [9242611] EMBO J. 1997 Sep 1;16(17):5386-97 [9311998] J Exp Med. 1997 Oct 6;186(7):1165-70 [9314565] J Biol Chem. 1997 Oct 10;272(41):25417-20 [9325248] Curr Biol. 1997 Dec 1;7(12):1003-6 [9382840] Immunity. 1997 Dec;7(6):813-20 [9430226] Nat Med. 1999 Feb;5(2):157-63 [9930862] J Immunol. 1999 May 1;162(9):5616-23 [10228045] J Clin Invest. 1999 Jul;104(2):155-62 [10411544] Cancer Res. 1965 May;25:477-83 [14297485] Ann Clin Lab Sci. 2004 Autumn;34(4):400-4 [15648780] Cancer Gene Ther. 2005 Mar;12(3):228-37 [15550937] Drug Resist Updat. 2004 Dec;7(6):345-58 [15790545] Br J Cancer. 2005 Apr 25;92(8):1430-41 [15846298] Lab Invest. 2005 Jul;85(7):885-94 [15864316] Br J Haematol. 2005 Aug;130(4):501-10 [16098063] Hepatology. 2005 Sep;42(3):588-97 [16037944] Cancer Biol Ther. 2005 Jul;4(7):781-6 [16082182] Ann Hematol. 2005 Oct;84(11):728-33 [16007425] Curr Opin Mol Ther. 2005 Oct;7(5):502-10 [16248286] Int J Oncol. 2006 Jan;28(1):127-33 [16327988] Ann N Y Acad Sci. 2005 Nov;1059:160-7 [16382051] Int J Oncol. 2006 Feb;28(2):421-30 [16391797] J Urol. 2006 Feb;175(2):432-8 [16406966] Cancer Res. 2006 Feb 15;66(4):2367-75 [16489043] Mol Cancer Ther. 2006 Jul;5(7):1844-53 [16891471] Eur J Cancer. 2006 Sep;42(14):2233-40 [16884904] BMC Cancer. 2006;6:214 [16930472] Pathol Oncol Res. 2006;12(3):133-42 [16998592] Appl Microbiol Biotechnol. 2006 Nov;73(1):1-14 [17013601] Mol Cancer Ther. 2006 Nov;5(11):2737-46 [17121920] Apoptosis. 2007 Jan;12(1):55-71 [17136498] Curr Opin Mol Ther. 2006 Dec;8(6):539-46 [17243490] Apoptosis. 2007 Apr;12(4):635-55 [17252198] Biochem Biophys Res Commun. 2007 Apr 27;356(1):260-5 [17350598] Nat Protoc. 2006;1(3):1112-6 [17406391] J Clin Oncol. 2007 Apr 10;25(11):1390-5 [17416859] J Urol. 2007 May;177(5):1894-9 [17437844] Int J Biochem Cell Biol. 2007;39(7-8):1462-75 [17403612] Future Oncol. 2007 Aug;3(4):405-9 [17661715] Neurosci Res. 2007 Sep;59(1):40-6 [17707539] Cancer Lett. 2007 Oct 28;256(2):267-78 [17681423] Prostate. 2007 Nov 1;67(15):1641-53 [17823925] Expert Opin Ther Targets. 2007 Oct;11(10):1299-314 [17907960] Clin Cancer Res. 2007 Oct 15;13(20):6187-94 [17947486] Toxicol Appl Pharmacol. 2007 Nov 1;224(3):284-9 [17240413] Nat Rev Mol Cell Biol. 2008 May;9(5):402-12 [18431400] Cancer Immunol Immunother. 2008 Oct;57(10):1523-9 [18488219] Cancer Res. 2001 Feb 1;61(3):1162-70 [11221847] Cell Growth Differ. 2001 Mar;12(3):147-55 [11306515] Pathol Oncol Res. 2001;7(2):95-106 [11458271] J Pharmacol Exp Ther. 2001 Oct;299(1):31-8 [11561060] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00262-008-0637-8 ER - TY - JOUR T1 - Adult versus adolescent onset of smoking: how are mood disorders and other risk factors involved? AN - 37178354; 3886016 AB - Aims To examine the strength of association between smoking and mood disorders and the association between smoking and its traditional risk factors, comparing those who started smoking in adolescence with those who started smoking in early adulthood. Design and participants The analyses relied on prospective data from the Zurich Study. This longitudinal community study started in 1979 with a stratified sample of 591 participants aged 20/21 years, weighted towards those with mental disorders. Follow-up interviews were conducted at ages 23, 28, 30, 35 and 41. Measurements In this analysis the adult versus adolescent onset of smoking was regressed on the cumulative prevalence of mood disorders, personality characteristics measured by the Freiburg Personality Inventory, common risk factors such as parental smoking, conduct and school problems, troubles with the family and basic socio-demographic variables (sex, education). Findings In the Zurich Study cohort we found that 61.6% were former or current smokers, of whom 87% started smoking before the age of 20 and 13% after the age of 20. Adolescent onset of smoking was associated strongly with later major depression, dysthymia or bipolar disorders and, furthermore, with parental smoking, extroverted personality and discipline problems and rebelliousness in youth. However, only depression and dysthymia were associated with adult onset smoking and other risk factors associated with smoking were not so associated in this group. Conclusions Correlates of smoking onset in adolescence are mainly not applicable to the onset of smoking in young adulthood. Smoking onset beyond adolescence is an open research issue. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Ajdacic-Gross, Vladeta AU - Landolt, Karin AU - Angst, Jules AU - Gamma, Alex AU - Merikangas, Kathleen R AU - Gutzwiller, Felix AU - Rössler, Wulf AD - Universität Zürich ; National Institute of Mental Health, US Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1411 EP - 1419 VL - 104 IS - 8 SN - 0965-2140, 0965-2140 KW - Sociology KW - Mood KW - Smoking KW - Depression KW - Epidemiology KW - Tobacco KW - Social problems KW - Health KW - Addiction KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37178354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Adult+versus+adolescent+onset+of+smoking%3A+how+are+mood+disorders+and+other+risk+factors+involved%3F&rft.au=Ajdacic-Gross%2C+Vladeta%3BLandolt%2C+Karin%3BAngst%2C+Jules%3BGamma%2C+Alex%3BMerikangas%2C+Kathleen+R%3BGutzwiller%2C+Felix%3BR%C3%B6ssler%2C+Wulf&rft.aulast=Ajdacic-Gross&rft.aufirst=Vladeta&rft.date=2009-08-01&rft.volume=104&rft.issue=8&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2009.02640.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 593; 4357 7894; 12766 3055 798 10286; 11755 5707 6071 1542 11325; 3439 4196 7951 6220 7954; 8269 4196; 5772; 561 6220; 11893 11979 DO - http://dx.doi.org/10.1111/j.1360-0443.2009.02640.x ER - TY - JOUR T1 - Socio-demographic risk factors for alcohol and drug dependence: the 10-year follow-up of the national comorbidity survey AN - 37178256; 3886008 AB - Aims Continued progress in etiological research and prevention science requires more precise information concerning the specific stages at which socio-demographic variables are implicated most strongly in transition from initial substance use to dependence. The present study examines prospective associations between socio-demographic variables and the subsequent onset of alcohol and drug dependence using data from the National Comorbidity Survey (NCS) and the NCS Follow-up survey (NCS-2). Design The NCS was a nationally representative survey of the prevalence and correlates of DSM-III-R mental and substance disorders in the United States carried out in 1990-2002. The NCS-2 re-interviewed a probability subsample of NCS respondents a decade after the baseline survey. Baseline NCS socio-demographic characteristics and substance use history were examined as predictors of the first onset of DSM-IV alcohol and drug dependence in the NCS-2. Participants A total of 5001 NCS respondents were re-interviewed in the NCS-2 (87.6% of baseline sample). Findings Aggregate analyses demonstrated significant associations between some baseline socio-demographic variables (young age, low education, non-white ethnicity, occupational status) but not others (sex, number of children, residential area) and the subsequent onset of DSM-IV alcohol or drug dependence. However, conditional models showed that these risk factors were limited to specific stages of baseline use. Moreover, many socio-demographic variables that were not significant in the aggregate analyses were significant predictors of dependence when examined by stage of use. Conclusions The findings underscore the potential for socio-demographic risk factors to have highly specific associations with different stages of the substance use trajectory. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Swendsen, Joel AU - Conway, Kevin P AU - Degenhardt, Louisa AU - Dierker, Lisa AU - Glantz, Meyer AU - Jin, Robert AU - Merikangas, Kathleen R AU - Sampson, Nancy AU - Kessler, Ronald C AD - Centre National de la Recherche Scientifique ; National Institutes of Health, US ; University of New South Wales ; Wesleyan University ; Harvard University ; National Institute of Mental Health, US Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1346 EP - 1355 VL - 104 IS - 8 SN - 0965-2140, 0965-2140 KW - Sociology KW - Longitudinal studies KW - Demography KW - Ethnicity KW - Alcoholism KW - Social problems KW - Health KW - Addiction KW - Drug abuse KW - Social factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37178256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Current+status+of+nanotechnology+approaches+for+cardiovascular+disease%3A+a+personal+perspective&rft.au=Buxton%2C+Denis+B&rft.aulast=Buxton&rft.aufirst=Denis&rft.date=2009-03-01&rft.volume=1&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.8 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5772; 913 561 6220; 4435; 3742 1121 11776 3753 3755; 3412; 7541 7537 971; 11839; 561 6220; 11893 11979 DO - http://dx.doi.org/10.1111/j.1360-0443.2009.02622.x ER - TY - JOUR T1 - Commetary low-risk drinking limits: absolute versus relative risk AN - 37177540; 3886002 JF - Addiction AU - Dawson, Deborah A AD - National Institutes of Health, US Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1303 EP - 1304 VL - 104 IS - 8 SN - 0965-2140, 0965-2140 KW - Sociology KW - Age KW - Alcoholism KW - Gender KW - Social problems KW - Health KW - Addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37177540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Commetary+low-risk+drinking+limits%3A+absolute+versus+relative+risk&rft.au=Dawson%2C+Deborah+A&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2009-08-01&rft.volume=104&rft.issue=8&rft.spage=1303&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5772; 646; 5421 6091; 913 561 6220; 561 6220; 11893 11979 ER - TY - JOUR T1 - Natural Killer Cell Counts Are Not Different between Patients with Post-Lyme Disease Syndrome and Controls AN - 21497497; 12492680 AB - It has been reported that patients with QUOTATION_MARKchronic Lyme diseaseQUOTATION_MARK have a decreased number of natural killer cells, as defined by the CD57 marker. We performed immunophenotyping in 9 individuals with post-Lyme disease syndrome, 12 who recovered from Lyme disease, and 9 healthy volunteers. The number of natural killer cells was not significantly different between the groups. JF - Clinical and Vaccine Immunology AU - Marques, Adriana AU - Brown, Margaret R AU - Fleisher, Thomas A AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, amarques@niaid.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1249 EP - 1250 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 16 IS - 8 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - CD57 antigen KW - Lyme disease KW - Natural killer cells KW - Borrelia KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21497497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Natural+Killer+Cell+Counts+Are+Not+Different+between+Patients+with+Post-Lyme+Disease+Syndrome+and+Controls&rft.au=Marques%2C+Adriana%3BBrown%2C+Margaret+R%3BFleisher%2C+Thomas+A&rft.aulast=Marques&rft.aufirst=Adriana&rft.date=2009-08-01&rft.volume=16&rft.issue=8&rft.spage=1249&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00167-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - CD57 antigen; Natural killer cells; Lyme disease; Borrelia DO - http://dx.doi.org/10.1128/CVI.00167-09 ER - TY - JOUR T1 - Binding of ATP and its derivatives to selenophosphate synthetase from Escherichia coli AN - 21255646; 11780189 AB - Mechanistically similar selenophosphate synthetases (SPS) have been isolated from different organisms. SPS from Escherichia coli is an ATP-dependent enzyme with a C-terminal glycine-rich Walker sequence that has been assumed to take part in the first step of ATP binding. Three C-terminally truncated mutants of SPS, containing the N-terminal 238 (SPS sub(238)), 262 (SPS sub(262)), and 332 (SPS sub(332)) amino acids of the 348-amino-acid protein, have been extracted from cell pellets, and two of these (SPS sub(262) and SPS sub(332)) have been purified to homogeneity. SPS sub(238) has been obtained in a highly purified form. Binding of the fluorescent ATP-derivative TNP-ATP and Mn-ATP to the proteins was examined for all truncated mutants of SPS and a catalytically inactive C17S mutant. It has been shown that TNP-ATP can be used as a structural probe for ATP-binding sites of SPS. We observed two TNP-ATP binding sites per molecule of enzyme for wild-type SPS and SPS sub(332) mutant and one TNP-ATP binding site for SPS sub(238) mutant. The stoichiometry of Mn-ATP-binding was 2 mol of ATP per mol of protein determined with [ super(14)C]ATP by HPLC gel-filtration column chromatography under saturating conditions. The binding stoichiometries for SPS sub(332), SPS sub(262), and SPS sub(238) were 2, 1.6, and 1, respectively. The C17S mutant exhibits about one third of wild type SPS TNP-ATP-binding ability and converts 12% of ATP in the ATPase reaction to ADP in the absence of selenide. The C-terminus contributes two thirds to the TNP-ATP binding; SPS sub(238) likely has one ATP-binding site removed by truncation. JF - Biochemistry AU - Preabrazhenskaya, Y V AU - Kim, I Y AU - Stadtman, T C AD - Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA, yuliya.preabrazh@gmail.com Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 910 EP - 916 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 74 IS - 8 SN - 0006-2979, 0006-2979 KW - Microbiology Abstracts B: Bacteriology KW - High-performance liquid chromatography KW - Adenosinetriphosphatase KW - Amino acids KW - selenophosphate KW - C-Terminus KW - Escherichia coli KW - Probes KW - ATP KW - Enzymes KW - Column chromatography KW - selenide KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21255646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Pulsed+High+Intensity+Focused+Ultrasound+Mediated+Nanoparticle+Delivery%3A+Mechanisms+and+Efficacy+in+Murine+Muscle&rft.au=O%27Neill%2C+Brian+E%3BVo%2C+Howard%3BAngstadt%2C+Mary%3BLi%2C+King+P+C%3BQuinn%2C+Tim%3BFrenkel%2C+Victor&rft.aulast=O%27Neill&rft.aufirst=Brian&rft.date=2009-03-01&rft.volume=35&rft.issue=3&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2008.09.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Amino acids; Adenosinetriphosphatase; C-Terminus; selenophosphate; Probes; selenide; Column chromatography; Enzymes; ATP; Escherichia coli DO - http://dx.doi.org/10.1134/S0006297909080136 ER - TY - JOUR T1 - Molecular Basis of DFNB73: Mutations of BSND Can Cause Nonsyndromic Deafness or Bartter Syndrome AN - 20796857; 10895800 AB - BSND encodes barttin, an accessory subunit of renal and inner ear chloride channels. To date, all mutations of BSND have been shown to cause Bartter syndrome type IV, characterized by significant renal abnormalities and deafness. We identified a BSND mutation (p.I12T) in four kindreds segregating nonsyndromic deafness linked to a 4.04-cM interval on chromosome 1p32.3. The functional consequences of p.I12T differ from BSND mutations that cause renal failure and deafness in Bartter syndrome type IV. p.I12T leaves chloride channel function unaffected and only interferes with chaperone function of barttin in intracellular trafficking. This study provides functional data implicating a hypomorphic allele of BSND as a cause of apparent nonsyndromic deafness. We demonstrate that BSND mutations with different functional consequences are the basis for either syndromic or nonsyndromic deafness. JF - American Journal of Human Genetics AU - Riazuddin, Saima AU - Anwar, Saima AU - Fischer, Martin AU - Ahmed, Zubair M AU - Khan, Shahid Y AU - Janssen, Audrey GH AU - Zafar, Ahmad U AU - Scholl, Ute AU - Husnain, Tayyab AU - Belyantseva, Inna A AU - Friedman, Penelope L AU - Riazuddin, Sheikh AU - Friedman, Thomas B AU - Fahlke, Christoph AD - Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA, fahlke.christoph@mh-hannover.de Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 273 EP - 280 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 85 IS - 2 SN - 0002-9297, 0002-9297 KW - Toxicology Abstracts; Genetics Abstracts KW - Deafness KW - Data processing KW - Kidney KW - Leaves KW - Chloride channels KW - Chromosome 1 KW - Renal failure KW - Chaperones KW - Mutation KW - Inner ear KW - G 07880:Human Genetics KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20796857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Human+Genetics&rft.atitle=Molecular+Basis+of+DFNB73%3A+Mutations+of+BSND+Can+Cause+Nonsyndromic+Deafness+or+Bartter+Syndrome&rft.au=Riazuddin%2C+Saima%3BAnwar%2C+Saima%3BFischer%2C+Martin%3BAhmed%2C+Zubair+M%3BKhan%2C+Shahid+Y%3BJanssen%2C+Audrey+GH%3BZafar%2C+Ahmad+U%3BScholl%2C+Ute%3BHusnain%2C+Tayyab%3BBelyantseva%2C+Inna+A%3BFriedman%2C+Penelope+L%3BRiazuddin%2C+Sheikh%3BFriedman%2C+Thomas+B%3BFahlke%2C+Christoph&rft.aulast=Riazuddin&rft.aufirst=Saima&rft.date=2009-08-01&rft.volume=85&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Human+Genetics&rft.issn=00029297&rft_id=info:doi/10.1016%2Fj.ajhg.2009.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Deafness; Data processing; Leaves; Kidney; Renal failure; Chromosome 1; Chloride channels; Chaperones; Inner ear; Mutation DO - http://dx.doi.org/10.1016/j.ajhg.2009.07.003 ER - TY - JOUR T1 - Alcohol and Risk of Breast Cancer by Histologic Type and Hormone Receptor Status in Postmenopausal Women AN - 20774370; 10835198 AB - Little is known about the association between alcohol and breast cancer by different tumor characteristics. The study consisted of 184,418 postmenopausal women aged 50-71 years in the National Institutes of Health-AARP Diet and Health Study (1995-2003). Alcohol use, diet, and potential risk factors for cancer were assessed with a mailed questionnaire at baseline. The relative risks and 95% confidence intervals were estimated by using Cox proportional hazards regression. Breast cancer cases and estrogen receptor and progesterone receptor status were identified through linkage to state cancer registries. During an average of 7 years of follow-up, 5,461 breast cancer cases were identified. Alcohol was significantly positively associated with total breast cancer: Even a moderate amount of alcohol (>10 g/day) significantly increased breast cancer risk. In a comparison of >35 g versus 0 g/day, the multivariate relative risks were 1.35 (95% confidence interval (CI): 1.17, 1.56) for total breast cancer, 1.46 (95% CI: 1.22, 1.75) for ductal tumors, and 1.52 (95% CI: 0.95, 2.44) for lobular tumors. The multivariate relative risks for estrogen receptor-positive/progesterone receptor-positive, estrogen receptor-positive/progesterone receptor-negative, and estrogen receptor-negative/progesterone receptor-negative tumors were 1.46 (95% CI: 1.12, 1.91) for >35 g versus 0 g/day, 1.13 (95% CI: 0.73, 1.77) for >20 g versus 0 g/day, and 1.21 (95% CI: 0.79, 1.84) for >20 g versus 0 g/day, respectively. Moderate consumption of alcohol was associated with breast cancer, specifically hormone receptor-positive tumors. JF - American Journal of Epidemiology AU - Lew, Jasmine Q AU - Freedman, Neal D AU - Leitzmann, Michael F AU - Brinton, Louise A AU - Hoover, Robert N AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Park, Yikyung Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - 308 EP - 317 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 170 IS - 3 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Health & Safety Science Abstracts KW - alcohol drinking KW - breast neoplasms KW - carcinoma, ductal, breast KW - carcinoma, lobular KW - receptors, estrogen KW - receptors, progesterone KW - Diets KW - Alcohol KW - post-menopause KW - Breast cancer KW - tumors KW - Females KW - Hormones KW - Cancer KW - estrogens KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20774370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=A+screening+study+of+thyroid+cancer+and+other+thyroid+diseases+among+individuals+exposed+in+utero+to+iodine-131+from+Chernobyl+fallout.&rft.au=Hatch%2C+M%3BBrenner%2C+A%3BBogdanova%2C+T%3BDerevyanko%2C+A%3BKuptsova%2C+N%3BLikhtarev%2C+I%3BBouville%2C+A%3BTereshchenko%2C+V%3BKovgan%2C+L%3BShpak%2C+V%3BOstroumova%2C+E%3BGreenebaum%2C+E%3BZablotska%2C+L%3BRon%2C+E%3BTronko%2C+M&rft.aulast=Hatch&rft.aufirst=M&rft.date=2009-03-01&rft.volume=94&rft.issue=3&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=1945-7197&rft_id=info:doi/10.1210%2Fjc.2008-2049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Alcohol; post-menopause; Breast cancer; tumors; Females; Hormones; Cancer; estrogens DO - http://dx.doi.org/10.1093/aje/kwp120 ER - TY - JOUR T1 - CORAL: aligning conserved core regions across domain families AN - 20774231; 10835303 AB - Motivation: Homologous protein families share highly conserved sequence and structure regions that are frequent targets for comparative analysis of related proteins and families. Many protein families, such as the curated domain families in the Conserved Domain Database (CDD), exhibit similar structural cores. To improve accuracy in aligning such protein families, we propose a profile-profile method CORAL that aligns individual core regions as gap-free units.Results: CORAL computes optimal local alignment of two profiles with heuristics to preserve continuity within core regions. We benchmarked its performance on curated domains in CDD, which have pre-defined core regions, against COMPASS, HHalign and PSI-BLAST, using structure superpositions and comprehensive curator-optimized alignments as standards of truth. CORAL improves alignment accuracy on core regions over general profile methods, returning a balanced score of 0.57 for over 80% of all domain families in CDD, compared with the highest balanced score of 0.45 from other methods. Further, CORAL provides E-values to aid in detecting homologous protein families and, by respecting block boundaries, produces alignments with improved 'readability' that facilitate manual refinement.Availability: CORAL will be included in future versions of the NCBI Cn3D/CDTree software, which can be downloaded at http://www.ncbi.nlm.nih.gov/Structure/cdtree/cdtree.shtml. Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Fong, Jessica H AU - Marchler-Bauer, Aron Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - 1862 EP - 1868 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 25 IS - 15 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Databases KW - software KW - Compasses KW - Data processing KW - Boundaries KW - protein families KW - Problem solving KW - Conserved sequence KW - Corals KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20774231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=CORAL%3A+aligning+conserved+core+regions+across+domain+families&rft.au=Fong%2C+Jessica+H%3BMarchler-Bauer%2C+Aron&rft.aulast=Fong&rft.aufirst=Jessica&rft.date=2009-08-01&rft.volume=25&rft.issue=15&rft.spage=1862&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Databases; Computer programs; software; Data processing; Compasses; Boundaries; Conserved sequence; Problem solving; protein families; Corals; Bioinformatics DO - http://dx.doi.org/10.1093/bioinformatics/btp334 ER - TY - JOUR T1 - Risk of Classic Kaposi Sarcoma with Residential Exposure to Volcanic and Related Soils in Sicily AN - 20177626; 10258764 AB - Before AIDS, endemic (African) Kaposi sarcoma (KS) was noted to occur in volcanic areas and was postulated to result from dirt chronically embedded in the skin of the lower extremities. The primary cause of all KS types is KS-associated herpesvirus (KSHV) infection, but cofactors contribute to the neoplasia. We investigated whether residential exposure to volcanic or related soils was associated with the risk of classic Kaposi sarcoma (cKS) in Sicily. Methods - Risk of incident cKS (N = 141) compared with population-based KSHV seropositive controls (N = 123) was estimated for residential exposure to four types of soil, categorized with maps from the European Soil Database and direct surveying. Questionnaire data provided covariates. Results - Residents in communities high in luvisols were approximately 2.7 times more likely to have cKS than those in communities with no luvisols. Risk was not specific for cKS on the limbs, but it was elevated approximately four- to five-fold with frequent bathing or tap water drinking in communities with high luvisols. Risk was unrelated to communities high in andosols, tephra, or clay soils. Conclusions - Iron and alumino-silicate clay, major components of luvisols, may increase cKS risk, but formal investigation and consideration of other soil types and exposures are needed. JF - Annals of Epidemiology AU - Pelser, Colleen AU - Dazzi, Carmelo AU - Graubard, Barry I AU - Lauria, Carmela AU - Vitale, Francesco AU - Goedert, James J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, goedertj@mail.nih.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 597 EP - 601 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 19 IS - 8 SN - 1047-2797, 1047-2797 KW - Toxicology Abstracts; Risk Abstracts KW - Herpesviridae, Kaposi Sarcoma, Italy KW - Soils KW - Soil types KW - Acquired immune deficiency syndrome KW - Herpesvirus KW - Maps KW - Infection KW - Neoplasia KW - Clays KW - Soil KW - Extremities KW - Surveying KW - Soils (volcanic) KW - Inventories KW - Clay KW - Skin KW - Data processing KW - Kaposi's sarcoma-associated herpesvirus KW - Volcanoes KW - Databases KW - Limbs KW - Cofactors KW - Italy, Sicilia KW - Residential areas KW - Sarcoma KW - Africa KW - Drinking water KW - Iron KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20177626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Risk+of+Classic+Kaposi+Sarcoma+with+Residential+Exposure+to+Volcanic+and+Related+Soils+in+Sicily&rft.au=Pelser%2C+Colleen%3BDazzi%2C+Carmelo%3BGraubard%2C+Barry+I%3BLauria%2C+Carmela%3BVitale%2C+Francesco%3BGoedert%2C+James+J&rft.aulast=Pelser&rft.aufirst=Colleen&rft.date=2009-08-01&rft.volume=19&rft.issue=8&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2009.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Soil types; Inventories; Acquired immune deficiency syndrome; Data processing; Skin; Infection; Maps; Neoplasia; Clays; Databases; Cofactors; Limbs; Sarcoma; Drinking water; Iron; Soils (volcanic); Extremities; Soil; Clay; Surveying; Residential areas; Volcanoes; Herpesvirus; Kaposi's sarcoma-associated herpesvirus; Italy, Sicilia; Africa DO - http://dx.doi.org/10.1016/j.annepidem.2009.04.002 ER - TY - JOUR T1 - Does hormone treatment added to radiotherapy improve outcome in locally advanced prostate cancer? AN - 20147446; 10259931 AB - BACKGROUND: To quantify the magnitude of benefit of the addition of hormone treatment (HT) to exclusive radiotherapy for locally advanced prostate cancer, a literature-based meta-analysis was conducted. METHODS: Event-based relative risks (RR) with 95% confidence intervals (CIs) were derived through a random-effect model. Differences in primary (biochemical failure and clinical progression-free survival) and secondary outcomes (cancer-specific survival, overall survival [OS], recurrence patterns, and toxicity) were explored. Absolute differences and numbers of patients needed to treat (NNT) were calculated. A heterogeneity test, a metaregression analysis with clinical predictors of outcome, and a correlation analysis for surrogate endpoints were also performed. RESULTS: Seven trials (4387 patients) were gathered. Hormone suppression significantly decreased both biochemical failure (RR, 0.76; 95% CI, 0.70-0.82; P < .0001) and clinical progression-free survival (RR, 0.81; 95% CI 0.71-0.93; P = .002), with absolute differences of 10% and 7.7%, respectively, which translates into 10 and 13 NNT. cancer-specific survival (RR, 0.76; 95% CI, 0.69-0.83; P < .0001) and OS (RR, 0.86; 95% CI, 0.80-0.93; P < .0001) were also significantly improved by the addition of HT, without significant heterogeneity, with absolute differences of 5.5% and 4.9%, respectively, which translates into 18 and 20 NNT. Local and distant relapse were significantly decreased by HT, by 36% and 28%, respectively, and no significant differences in toxicity were found. Primary and secondary efficacy outcomes were significantly correlated. CONCLUSIONS: Hormone suppression plus radiotherapy significantly decreases recurrence and mortality of patients with localized prostate cancer, without affecting toxicity. Cancer 2009. JF - Cancer AU - Bria, Emilio AU - Cuppone, Federica AU - Giannarelli, Diana AU - Milella, Michele AU - Ruggeri, Enzo Maria AU - Sperduti, Isabella AU - Pinnaro, Paola AU - Terzoli, Edmondo AU - Cognetti, Francesco AU - Carlini, Paolo AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy, emiliobria@yahoo.it Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 3446 EP - 3456 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA, [mailto:info@wiley.com], [URL:http://www.wiley.com/WileyCDA/Brand/id-35.html] VL - 115 IS - 15 SN - 0008-543X, 0008-543X KW - Toxicology Abstracts KW - Risk assessment KW - Mortality KW - Prostate cancer KW - Reviews KW - Survival KW - Radiotherapy KW - Toxicity KW - Correlation analysis KW - Hormones KW - Clinical trials KW - Models KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20147446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Does+hormone+treatment+added+to+radiotherapy+improve+outcome+in+locally+advanced+prostate+cancer%3F&rft.au=Bria%2C+Emilio%3BCuppone%2C+Federica%3BGiannarelli%2C+Diana%3BMilella%2C+Michele%3BRuggeri%2C+Enzo+Maria%3BSperduti%2C+Isabella%3BPinnaro%2C+Paola%3BTerzoli%2C+Edmondo%3BCognetti%2C+Francesco%3BCarlini%2C+Paolo&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2009-08-01&rft.volume=115&rft.issue=15&rft.spage=3446&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24392 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Prostate cancer; Reviews; Radiotherapy; Survival; Correlation analysis; Toxicity; Clinical trials; Hormones; Models DO - http://dx.doi.org/10.1002/cncr.24392 ER - TY - JOUR T1 - Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27. AN - 67524281; 19506078 AB - Rho GTPases are critical components of cellular signal transduction pathways. Both hyperactivity and overexpression of these proteins have been observed in human cancers and have been implicated as important factors in metastasis. We previously showed that dietary n-6 fatty acids increase cancer cell adhesion to extracellular matrix proteins, such as type IV collagen. Here we report that in MDA-MB-435 human melanoma cells, arachidonic acid activates RhoA, and inhibition of RhoA signaling with either C3 exoenzyme or dominant negative Rho blocked arachidonic acid-induced cell adhesion. Inhibition of the Rho kinase (ROCK) with either small molecule inhibitors or ROCK II-specific small interfering RNA (siRNA) blocked the fatty acid-induced adhesion. However, unlike other systems, inhibition of ROCK did not block the activation of p38 mitogen-activated protein kinase (MAPK); instead, Rho activation depended on p38 MAPK activity and the presence of heat shock protein 27 (HSP27), which is phosphorylated downstream of p38 after arachidonic acid treatment. HSP27 associated with p115RhoGEF in fatty acid-treated cells, and this association was blocked when p38 was inhibited. Furthermore, siRNA knockdown of HSP27 blocked the fatty acid-stimulated Rho activity. Expression of dominant negative p115-RhoGEF or p115RhoGEF-specific siRNA inhibited both RhoA activation and adhesion on type IV collagen, whereas a constitutively active p115RhoGEF restored the arachidonic acid stimulation in cells in which the p38 MAPK had been inhibited. These data suggest that n-6 dietary fatty acids stimulate a set of interactions that regulates cell adhesion through RhoA and ROCK II via a p38 MAPK-dependent association of HSP27 and p115RhoGEF. JF - The Journal of biological chemistry AU - Garcia, Melissa C AU - Ray, Denise M AU - Lackford, Brad AU - Rubino, Mark AU - Olden, Kenneth AU - Roberts, John D AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 SP - 20936 EP - 20945 VL - 284 IS - 31 KW - ARHGEF1 protein, human KW - 0 KW - Collagen Type IV KW - Guanine Nucleotide Exchange Factors KW - HSP27 Heat-Shock Proteins KW - Rho Guanine Nucleotide Exchange Factors KW - Arachidonic Acid KW - 27YG812J1I KW - rho-Associated Kinases KW - EC 2.7.11.1 KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - rhoA GTP-Binding Protein KW - EC 3.6.5.2 KW - Index Medicus KW - rho-Associated Kinases -- metabolism KW - Cytoskeleton -- metabolism KW - Humans KW - Guanine Nucleotide Exchange Factors -- metabolism KW - Cell Shape -- drug effects KW - Enzyme Activation -- drug effects KW - Cell Movement -- drug effects KW - Cell Line, Tumor KW - Cell Adhesion -- drug effects KW - Models, Biological KW - Collagen Type IV -- metabolism KW - Cytoskeleton -- drug effects KW - rhoA GTP-Binding Protein -- metabolism KW - HSP27 Heat-Shock Proteins -- metabolism KW - Arachidonic Acid -- pharmacology KW - Signal Transduction -- drug effects KW - p38 Mitogen-Activated Protein Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67524281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Arachidonic+acid+stimulates+cell+adhesion+through+a+novel+p38+MAPK-RhoA+signaling+pathway+that+involves+heat+shock+protein+27.&rft.au=Garcia%2C+Melissa+C%3BRay%2C+Denise+M%3BLackford%2C+Brad%3BRubino%2C+Mark%3BOlden%2C+Kenneth%3BRoberts%2C+John+D&rft.aulast=Garcia&rft.aufirst=Melissa&rft.date=2009-07-31&rft.volume=284&rft.issue=31&rft.spage=20936&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.020271 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-14 N1 - Date created - 2009-07-27 N1 - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.020271 ER - TY - CPAPER T1 - Prognostic Role of Cytoskeletal Protein Human Mena (Hmena), Estrogen Receptorbeta (Er-Beta), and Epidermal Growth Factor Receptor (Egfr) in Resected Node-Negative Non-Small-Cell Lung Cancer (Nsclc) T2 - 13th World Conference on Lung Cancer AN - 40355611; 5265769 JF - 13th World Conference on Lung Cancer AU - Bria, Emilio Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Lung cancer KW - Estrogens KW - Growth factors KW - Epidermal growth factor receptors KW - Cytoskeleton KW - Sex hormones KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Prognostic+Role+of+Cytoskeletal+Protein+Human+Mena+%28Hmena%29%2C+Estrogen+Receptorbeta+%28Er-Beta%29%2C+and+Epidermal+Growth+Factor+Receptor+%28Egfr%29+in+Resected+Node-Negative+Non-Small-Cell+Lung+Cancer+%28Nsclc%29&rft.au=Bria%2C+Emilio&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Standardized Uptake Value at Positron Emission Tomography (Pet-Suv) Predicts Long-Term Survival of Ct Screening-Detected Lung Cancer in Heavy Smokers T2 - 13th World Conference on Lung Cancer AN - 40351887; 5265768 JF - 13th World Conference on Lung Cancer AU - Pastorino, Ugo Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Standards KW - Lung cancer KW - Survival KW - Emissions KW - Positron emission tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Standardized+Uptake+Value+at+Positron+Emission+Tomography+%28Pet-Suv%29+Predicts+Long-Term+Survival+of+Ct+Screening-Detected+Lung+Cancer+in+Heavy+Smokers&rft.au=Pastorino%2C+Ugo&rft.aulast=Pastorino&rft.aufirst=Ugo&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeting Mtor for Lung Cancer Prevention T2 - 13th World Conference on Lung Cancer AN - 40340827; 5265061 JF - 13th World Conference on Lung Cancer AU - Dennis, Philip Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Prevention KW - Lung cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40340827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Targeting+Mtor+for+Lung+Cancer+Prevention&rft.au=Dennis%2C+Philip&rft.aulast=Dennis&rft.aufirst=Philip&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dose Escalation Trials Based on a Molecularly Targeted Endpoint T2 - 13th World Conference on Lung Cancer AN - 40340795; 5264926 JF - 13th World Conference on Lung Cancer AU - Hunsberger, Sally Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40340795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Dose+Escalation+Trials+Based+on+a+Molecularly+Targeted+Endpoint&rft.au=Hunsberger%2C+Sally&rft.aulast=Hunsberger&rft.aufirst=Sally&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Advances in Mouse Models of Lung Cancer T2 - 13th World Conference on Lung Cancer AN - 40340784; 5265050 JF - 13th World Conference on Lung Cancer AU - Linnoila, Ilona Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Lung cancer KW - Animal models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40340784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Advances+in+Mouse+Models+of+Lung+Cancer&rft.au=Linnoila%2C+Ilona&rft.aulast=Linnoila&rft.aufirst=Ilona&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Histologic Diagnosis: Prognosis II T2 - 13th World Conference on Lung Cancer AN - 40340689; 5265015 JF - 13th World Conference on Lung Cancer AU - Linnoila, Ilona Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Prognosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40340689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Histologic+Diagnosis%3A+Prognosis+II&rft.au=Linnoila%2C+Ilona&rft.aulast=Linnoila&rft.aufirst=Ilona&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hylar Non Small Cell Lung Cancer Infi Ltrating Mediastinal Vessels. How Often Is Pneumonectomy Required? T2 - 13th World Conference on Lung Cancer AN - 40337701; 5265308 JF - 13th World Conference on Lung Cancer AU - Leo, Francesco Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Lung cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Hylar+Non+Small+Cell+Lung+Cancer+Infi+Ltrating+Mediastinal+Vessels.+How+Often+Is+Pneumonectomy+Required%3F&rft.au=Leo%2C+Francesco&rft.aulast=Leo&rft.aufirst=Francesco&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Signal Transduction Pathways T2 - 13th World Conference on Lung Cancer AN - 40336651; 5264933 JF - 13th World Conference on Lung Cancer AU - Giaccone, Giuseppe Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Signal transduction KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Novel+Signal+Transduction+Pathways&rft.au=Giaccone%2C+Giuseppe&rft.aulast=Giaccone&rft.aufirst=Giuseppe&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory Proteins T2 - 13th World Conference on Lung Cancer AN - 40335878; 5264831 JF - 13th World Conference on Lung Cancer AU - Szabo, Eva Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Inflammatory+Proteins&rft.au=Szabo%2C+Eva&rft.aulast=Szabo&rft.aufirst=Eva&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Surgery in Chest Wall Invasion for Nsclc T2 - 13th World Conference on Lung Cancer AN - 40335527; 5265304 JF - 13th World Conference on Lung Cancer AU - Lequaglie, Cosimo Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Surgery KW - Chest KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Role+of+Surgery+in+Chest+Wall+Invasion+for+Nsclc&rft.au=Lequaglie%2C+Cosimo&rft.aulast=Lequaglie&rft.aufirst=Cosimo&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perspective Study Analysis of Quality of Life and Effi Cacy of Pleurodesis by Uniportal Access Video-Assisted-Thoracoscopy for Malignant Pleural Effusions T2 - 13th World Conference on Lung Cancer AN - 40334613; 5265487 JF - 13th World Conference on Lung Cancer AU - Giudice, Gabriella Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Quality of life KW - Pleural effusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Perspective+Study+Analysis+of+Quality+of+Life+and+Effi+Cacy+of+Pleurodesis+by+Uniportal+Access+Video-Assisted-Thoracoscopy+for+Malignant+Pleural+Effusions&rft.au=Giudice%2C+Gabriella&rft.aulast=Giudice&rft.aufirst=Gabriella&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicity of Eortc 08031: Phase Ii Feasibility Trial of Induction Chemotherapy (Ict) Followed by Extrapleural Pneumonectomy (Epp) and Postoperative Radiotherapy (Port) for Malignant Pleural Mesothelioma (Mpm) ct3n1m0 or Less T2 - 13th World Conference on Lung Cancer AN - 40334183; 5265266 JF - 13th World Conference on Lung Cancer AU - Gaafar, Rabab Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Toxicity KW - Chemotherapy KW - Mesothelioma KW - Radiotherapy KW - Feasibility studies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Toxicity+of+Eortc+08031%3A+Phase+Ii+Feasibility+Trial+of+Induction+Chemotherapy+%28Ict%29+Followed+by+Extrapleural+Pneumonectomy+%28Epp%29+and+Postoperative+Radiotherapy+%28Port%29+for+Malignant+Pleural+Mesothelioma+%28Mpm%29+ct3n1m0+or+Less&rft.au=Gaafar%2C+Rabab&rft.aulast=Gaafar&rft.aufirst=Rabab&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Utilization of Pain Medications and the Attitudes of Lung Cancer Patients towards Pain Intervention T2 - 13th World Conference on Lung Cancer AN - 40332659; 5265477 JF - 13th World Conference on Lung Cancer AU - Simone, Charles Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Pain KW - Attitudes KW - Lung cancer KW - Intervention KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=The+Utilization+of+Pain+Medications+and+the+Attitudes+of+Lung+Cancer+Patients+towards+Pain+Intervention&rft.au=Simone%2C+Charles&rft.aulast=Simone&rft.aufirst=Charles&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Primitive Neuroectodermal Tumor: Nine Years Single Institution Experience T2 - 13th World Conference on Lung Cancer AN - 40332226; 5266370 JF - 13th World Conference on Lung Cancer AU - Abedelrahman, Abdelrahman Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Tumors KW - Nervous system diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Primitive+Neuroectodermal+Tumor%3A+Nine+Years+Single+Institution+Experience&rft.au=Abedelrahman%2C+Abdelrahman&rft.aulast=Abedelrahman&rft.aufirst=Abdelrahman&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase Ii Study of the Histone Deacetylase (Hdac) Inhibitor Belinostat in Thymic Malignancies T2 - 13th World Conference on Lung Cancer AN - 40331938; 5266166 JF - 13th World Conference on Lung Cancer AU - Giaccone, Giuseppe Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Histone deacetylase KW - Malignancy KW - Thymus KW - Histones KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Phase+Ii+Study+of+the+Histone+Deacetylase+%28Hdac%29+Inhibitor+Belinostat+in+Thymic+Malignancies&rft.au=Giaccone%2C+Giuseppe&rft.aulast=Giaccone&rft.aufirst=Giuseppe&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Phase I Combination Study of Olaparib (azd2281; Ku-0059436) and Cisplatin plus Gemcitabine in Adults with Solid Tumors T2 - 13th World Conference on Lung Cancer AN - 40331604; 5265809 JF - 13th World Conference on Lung Cancer AU - Rajan, Arun Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Tumors KW - Cisplatin KW - Solid tumors KW - Gemcitabine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=A+Phase+I+Combination+Study+of+Olaparib+%28azd2281%3B+Ku-0059436%29+and+Cisplatin+plus+Gemcitabine+in+Adults+with+Solid+Tumors&rft.au=Rajan%2C+Arun&rft.aulast=Rajan&rft.aufirst=Arun&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Prognostic Markers in Malignant Pleural Mesothelioma (Mpm) T2 - 13th World Conference on Lung Cancer AN - 40328862; 5266163 JF - 13th World Conference on Lung Cancer AU - Gaafar, Rabab Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Mesothelioma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40328862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Molecular+Prognostic+Markers+in+Malignant+Pleural+Mesothelioma+%28Mpm%29&rft.au=Gaafar%2C+Rabab&rft.aulast=Gaafar&rft.aufirst=Rabab&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of New Iaslc Revised Staging System in Radically Resected Stage Iiia-B Nsclc with Adjuvant Therapy T2 - 13th World Conference on Lung Cancer AN - 40326675; 5265792 JF - 13th World Conference on Lung Cancer AU - Lequaglie, Cosimo Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Adjuvants KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40326675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Role+of+New+Iaslc+Revised+Staging+System+in+Radically+Resected+Stage+Iiia-B+Nsclc+with+Adjuvant+Therapy&rft.au=Lequaglie%2C+Cosimo&rft.aulast=Lequaglie&rft.aufirst=Cosimo&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons. AN - 67540138; 19641106 AB - Mitochondria in the cell bodies of neurons are transported down neuronal processes in response to changes in local energy and metabolic states. Because of their extreme polarity, neurons require specialized mechanisms to regulate mitochondrial transport and retention in axons. Our previous studies using syntaphilin (snph) knock-out mice provided evidence that SNPH targets to axonal mitochondria and controls their mobility through its static interaction with microtubules (MTs). However, the mechanisms regulating SNPH-mediated mitochondrial docking remain elusive. Here, we report an unexpected role for dynein light chain LC8. Using proteomic biochemical and cell biological assays combined with time-lapse imaging in live snph wild-type and mutant neurons, we reveal that LC8 regulates axonal mitochondrial mobility by binding to SNPH, thus enhancing the SNPH-MT docking interaction. Using mutagenesis assays, we mapped a seven-residue LC8-binding motif. Through this specific interaction, SNPH recruits LC8 to axonal mitochondria; such colocalization is abolished when neurons express SNPH mutants lacking the LC8-binding motif. Transient LC8 expression reduces mitochondrial mobility in snph (+/+) but not (-/-) neurons, suggesting that the observed effect of LC8 depends on the SNPH-mediated docking mechanism. In contrast, deleting the LC8-binding motif impairs the ability of SNPH to immobilize axonal mitochondria. Furthermore, circular dichroism spectrum analysis shows that LC8 stabilizes an alpha-helical coiled-coil within the MT-binding domain of SNPH against thermal unfolding. Thus, our study provides new mechanistic insights into controlling mitochondrial mobility through a dynamic interaction between the mitochondrial docking receptor and axonal cytoskeleton. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Chen, Yan-Min AU - Gerwin, Claudia AU - Sheng, Zu-Hang AD - Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke-National Institutes of Health, Bethesda, Maryland 20892-3706, USA. Y1 - 2009/07/29/ PY - 2009 DA - 2009 Jul 29 SP - 9429 EP - 9438 VL - 29 IS - 30 KW - Dynll2 protein, mouse KW - 0 KW - Microtubule-Associated Proteins KW - Myosin Light Chains KW - Snph protein, mouse KW - Dynll1 protein, rat KW - EC 3.6.1.- KW - Cytoplasmic Dyneins KW - EC 3.6.4.2 KW - Dyneins KW - Index Medicus KW - Rats KW - Animals KW - Hippocampus -- physiology KW - Cells, Cultured KW - Protein Stability KW - Neurons -- physiology KW - Mice KW - Cytoskeleton -- physiology KW - Protein Binding KW - Mutation KW - Binding Sites KW - Mitochondria -- physiology KW - Microtubule-Associated Proteins -- metabolism KW - Microtubule-Associated Proteins -- genetics KW - Myosin Light Chains -- genetics KW - Myosin Light Chains -- metabolism KW - Axons -- ultrastructure KW - Dyneins -- genetics KW - Dyneins -- metabolism KW - Axons -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67540138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Dynein+light+chain+LC8+regulates+syntaphilin-mediated+mitochondrial+docking+in+axons.&rft.au=Chen%2C+Yan-Min%3BGerwin%2C+Claudia%3BSheng%2C+Zu-Hang&rft.aulast=Chen&rft.aufirst=Yan-Min&rft.date=2009-07-29&rft.volume=29&rft.issue=30&rft.spage=9429&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.1472-09.2009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-19 N1 - Date created - 2009-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.1472-09.2009 ER - TY - JOUR T1 - Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. AN - 67573021; 19592511 AB - Seven-transmembrane-spanning receptors (7TMRs) are prominent drug targets. However, small-molecule ligands for 7-transmembrane-spanning receptors for which the natural ligands are large, heterodimeric glycoprotein hormones, like thyroid-stimulating hormone (TSH; thyrotropin), have only recently been reported, and none are approved for human use. We have used quantitative high-throughput screening to identify a small-molecule TSH receptor (TSHR) agonist that was modified to produce a second agonist with increased potency. We show that these agonists are highly selective for human TSHR versus other glycoprotein hormone receptors and interact with the receptor's serpentine domain. A binding pocket within the transmembrane domain was defined by docking into a TSHR homology model and was supported by site-directed mutagenesis. In primary cultures of human thyrocytes, both TSH and the agonists increase mRNA levels for thyroglobulin, thyroperoxidase, sodium iodide symporter, and deiodinase type 2, and deiodinase type 2 enzyme activity. Moreover, oral administration of the agonist stimulated thyroid function in mice, resulting in increased serum thyroxine and thyroidal radioiodide uptake. Thus, we discovered a small molecule that activates human TSHR in vitro, is orally active in mice, and could be a lead for development of drugs to use in place of recombinant human TSH in patients with thyroid cancer. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Neumann, Susanne AU - Huang, Wenwei AU - Titus, Steve AU - Krause, Gerd AU - Kleinau, Gunnar AU - Alberobello, Anna Teresa AU - Zheng, Wei AU - Southall, Noel T AU - Inglese, James AU - Austin, Christopher P AU - Celi, Francesco S AU - Gavrilova, Oksana AU - Thomas, Craig J AU - Raaka, Bruce M AU - Gershengorn, Marvin C AD - Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/07/28/ PY - 2009 DA - 2009 Jul 28 SP - 12471 EP - 12476 VL - 106 IS - 30 KW - 3-(furan-2-ylmethyl)-2-(4-methoxy-3-(phenoxymethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one KW - 0 KW - Acetamides KW - N-(4-(5-(3-(furan-2-ylmethyl)-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyloxy)phenyl)acetamide KW - N-(4-(5-(3-benzyl-5-hydroxy-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyloxy)phenyl)acetamide KW - Organic Chemicals KW - Quinazolinones KW - Receptors, Thyrotropin KW - Thyrotropin KW - 9002-71-5 KW - Thyroglobulin KW - 9010-34-8 KW - Cyclic AMP KW - E0399OZS9N KW - Iodide Peroxidase KW - EC 1.11.1.8 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Humans KW - Quinazolinones -- chemical synthesis KW - Thyroglobulin -- metabolism KW - Acetamides -- chemical synthesis KW - Iodide Peroxidase -- genetics KW - Thyroglobulin -- genetics KW - Iodide Peroxidase -- metabolism KW - Molecular Structure KW - Quinazolinones -- chemistry KW - Models, Molecular KW - Acetamides -- chemistry KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Binding Sites KW - Quinazolinones -- pharmacology KW - Acetamides -- pharmacology KW - Thyrotropin -- pharmacology KW - Transfection KW - Cells, Cultured KW - Cyclic AMP -- metabolism KW - Mice, Inbred C57BL KW - Protein Structure, Tertiary KW - Female KW - Cell Line KW - Receptors, Thyrotropin -- metabolism KW - Thyroid Gland -- physiology KW - Organic Chemicals -- chemistry KW - Thyroid Gland -- drug effects KW - Organic Chemicals -- chemical synthesis KW - Organic Chemicals -- pharmacology KW - Receptors, Thyrotropin -- agonists KW - Thyroid Gland -- cytology KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67573021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Small-molecule+agonists+for+the+thyrotropin+receptor+stimulate+thyroid+function+in+human+thyrocytes+and+mice.&rft.au=Neumann%2C+Susanne%3BHuang%2C+Wenwei%3BTitus%2C+Steve%3BKrause%2C+Gerd%3BKleinau%2C+Gunnar%3BAlberobello%2C+Anna+Teresa%3BZheng%2C+Wei%3BSouthall%2C+Noel+T%3BInglese%2C+James%3BAustin%2C+Christopher+P%3BCeli%2C+Francesco+S%3BGavrilova%2C+Oksana%3BThomas%2C+Craig+J%3BRaaka%2C+Bruce+M%3BGershengorn%2C+Marvin+C&rft.aulast=Neumann&rft.aufirst=Susanne&rft.date=2009-07-28&rft.volume=106&rft.issue=30&rft.spage=12471&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0904506106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-28 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biomol Screen. 2008 Feb;13(2):120-7 [18216391] J Med Chem. 2009 Apr 9;52(7):2036-42 [19296599] Thyroid. 2008 May;18(5):509-16 [18426363] Nature. 2008 Jul 10;454(7201):183-7 [18563085] Bone. 2008 Sep;43(3):418-26 [18585995] Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov;378(5):503-14 [18551279] Endocrinology. 2008 Dec;149(12):5945-50 [18669595] Science. 2000 Aug 4;289(5480):739-45 [10926528] J Biol Chem. 2000 Sep 1;275(35):27457-65 [10859314] Bioorg Med Chem. 2002 Mar;10(3):639-56 [11814852] Mol Endocrinol. 2002 Apr;16(4):736-46 [11923470] Endocrinology. 2002 Oct;143(10):3822-9 [12239093] Chembiochem. 2002 Oct 4;3(10):1023-6 [12362369] Endocr Rev. 2003 Feb;24(1):48-77 [12588808] Eur J Pharmacol. 2003 Sep 30;478(1):27-34 [14555181] Cell. 2003 Oct 17;115(2):151-62 [14567913] Trends Biochem Sci. 2004 Mar;29(3):119-26 [15003269] Bioorg Med Chem Lett. 2004 Apr 5;14(7):1713-6 [15026056] Bioorg Med Chem Lett. 2004 Apr 5;14(7):1717-20 [15026057] Vitam Horm. 1971;29:287-412 [4400011] J Endocrinol. 1981 Feb;88(2):205-17 [6259266] J Clin Invest. 1988 May;81(5):1476-84 [2835397] Endocr Rev. 1992 Aug;13(3):596-611 [1425489] J Mol Biol. 1993 Jun 20;231(4):1049-67 [8515464] Expert Opin Pharmacother. 2004 Dec;5(12):2435-40 [15571461] J Med Chem. 2005 Mar 24;48(6):1697-700 [15771412] J Biol Chem. 2006 Apr 14;281(15):9841-4 [16488885] J Biol Chem. 2006 May 12;281(19):13226-33 [16540466] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Thyroid. 2006 Jul;16(7):625-32 [16889485] J Clin Invest. 2006 Oct;116(10):2571-9 [17016550] Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8 [17060607] Bioorg Med Chem Lett. 2007 Apr 1;17(7):2080-5 [17321742] Mol Endocrinol. 2007 May;21(5):1095-107 [17327419] J Mol Biol. 2007 Oct 5;372(5):1179-88 [17825322] Nature. 2007 Nov 15;450(7168):383-7 [17952055] Science. 2007 Nov 23;318(5854):1258-65 [17962520] Mol Pharmacol. 2008 Feb;73(2):518-24 [17989351] Mol Endocrinol. 2008 Feb;22(2):501-12 [17932107] Science. 2008 Nov 21;322(5905):1211-7 [18832607] Best Pract Res Clin Endocrinol Metab. 2008 Dec;22(6):1009-21 [19041828] Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4289-94 [18332426] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0904506106 ER - TY - JOUR T1 - Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study. AN - 67538467; 19638649 AB - To evaluate the cumulative incidence of cervical intraepithelial neoplasia II or worse (grade II+) or cervical intraepithelial neoplasia grade III+ after short term persistence of prevalently detected carcinogenic human papillomavirus (HPV). Population based cohort study. Guanacaste, Costa Rica. 2282 sexually active women actively followed after enrolment. Primary end points: three year and five year cumulative incidence of histologically confirmed cervical intraepithelial neoplasia grade II+ (n=70). Cervical specimens collected at each visit tested for more than 40 HPV genotypes. HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 73, and 82 were considered the primary carcinogenic genotypes. Women who tested positive for a carcinogenic HPV at enrolment and after about one year (9-21 months) (positive/positive) had a three year cumulative incidence of cervical intraepithelial neoplasia grade II+ of 17.0% (95% confidence interval 12.1% to 22.0%). Those who tested negative/positive (3.4%, 0.1% to 6.8%), positive/negative (1.2%, -0.2% to 2.5%), and negative/negative (0.5%, 0.1% to 0.9%) were at a significantly lower risk. There was little difference in the cumulative incidence of cervical intraepithelial neoplasia grade II+ between testing positive twice for any carcinogenic HPV genotype (same genotype or different genotypes) v testing positive twice for the same carcinogenic genotype (17.0% v 21.3%, respectively). Short term persistence of HPV 16 strongly predicted cervical intraepithelial neoplasia grade II+, with a three year cumulative incidence of 40.8% (26.4% to 55.1%). Similar patterns were observed for the five year cumulative incidence of grade II+ and for three year and five year cumulative incidence of grade III+. Short term persistence of a prevalently detected carcinogenic HPV infection, especially HPV 16, strongly predicts a subsequent diagnosis of cervical intraepithelial neoplasia II+ over the next few years. JF - BMJ (Clinical research ed.) AU - Castle, Philip E AU - Rodríguez, Ana Cecilia AU - Burk, Robert D AU - Herrero, Rolando AU - Wacholder, Sholom AU - Alfaro, Mario AU - Morales, Jorge AU - Guillen, Diego AU - Sherman, Mark E AU - Solomon, Diane AU - Schiffman, Mark AU - Proyecto Epidemiológico Guanacaste (PEG) Group AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. castlep@mail.nih.gov ; Proyecto Epidemiológico Guanacaste (PEG) Group Y1 - 2009/07/28/ PY - 2009 DA - 2009 Jul 28 SP - 1 VL - 339 KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Aged, 80 and over KW - Risk Factors KW - Papillomaviridae -- isolation & purification KW - Humans KW - Cohort Studies KW - Adult KW - Incidence KW - Aged KW - Middle Aged KW - Adolescent KW - Costa Rica -- epidemiology KW - Female KW - Papillomavirus Infections -- epidemiology KW - Uterine Cervical Neoplasms -- epidemiology KW - Cervical Intraepithelial Neoplasia -- virology KW - Precancerous Conditions -- epidemiology KW - Precancerous Conditions -- virology KW - Uterine Cervical Neoplasms -- virology KW - Cervical Intraepithelial Neoplasia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67538467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28Clinical+research+ed.%29&rft.atitle=Short+term+persistence+of+human+papillomavirus+and+risk+of+cervical+precancer+and+cancer%3A+population+based+cohort+study.&rft.au=Castle%2C+Philip+E%3BRodr%C3%ADguez%2C+Ana+Cecilia%3BBurk%2C+Robert+D%3BHerrero%2C+Rolando%3BWacholder%2C+Sholom%3BAlfaro%2C+Mario%3BMorales%2C+Jorge%3BGuillen%2C+Diego%3BSherman%2C+Mark+E%3BSolomon%2C+Diane%3BSchiffman%2C+Mark%3BProyecto+Epidemiol%C3%B3gico+Guanacaste+%28PEG%29+Group&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2009-07-28&rft.volume=339&rft.issue=&rft.spage=b2569&rft.isbn=&rft.btitle=&rft.title=BMJ+%28Clinical+research+ed.%29&rft.issn=1756-1833&rft_id=info:doi/10.1136%2Fbmj.b2569 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-14 N1 - Date created - 2009-07-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] Cancer. 2004 Mar 1;100(5):1035-44 [14983500] Rev Panam Salud Publica. 2004 Feb;15(2):75-89 [15030652] Am J Clin Pathol. 2004 Aug;122(2):238-45 [15323141] Rev Panam Salud Publica. 1997 May;1(5):362-75 [9180057] J Infect Dis. 2005 Jun 1;191(11):1808-16 [15871112] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2191-9 [16172231] Am J Clin Pathol. 2005 Nov;124(5):716-21 [16203283] Int J Cancer. 2006 Sep 1;119(5):1095-101 [16586444] Am J Obstet Gynecol. 2006 Aug;195(2):349-53 [16677597] Vaccine. 2006 Aug 31;24 Suppl 3:S3/78-89 [16950021] Vaccine. 2006 Aug 31;24 Suppl 3:S3/90-7 [16950022] Cancer Res. 2006 Nov 1;66(21):10630-6 [17062559] Br J Cancer. 2007 Apr 23;96(8):1234-6 [17375047] Am J Clin Pathol. 2007 May;127(5):805-15 [17439841] J Infect Dis. 2007 Jun 1;195(11):1582-9 [17471427] Br J Cancer. 2007 May 7;96(9):1419-24 [17342094] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] N Engl J Med. 2007 Oct 18;357(16):1579-88 [17942871] N Engl J Med. 2007 Oct 18;357(16):1589-97 [17942872] Lancet. 2007 Nov 24;370(9601):1764-72 [17919718] J Natl Cancer Inst. 2008 Apr 2;100(7):513-7 [18364507] Am J Epidemiol. 2008 Jul 15;168(2):138-44; discussion 145-8 [18483124] Am J Epidemiol. 2008 Jul 15;168(2):123-37 [18483125] J Med Virol. 2002 Nov;68(3):417-23 [12226831] BMJ. 2002 Sep 14;325(7364):572 [12228133] JAMA. 2002 Oct 9;288(14):1749-57 [12365959] Comment In: BMJ. 2009;339:b3005 [19638652] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/bmj.b2569 ER - TY - JOUR T1 - Triage and Management of Accidental Laboratory Exposures to Biosafety Level-3 and -4 Agents AN - 1315605630; 17455096 AB - The recent expansion of biocontainment laboratory capacity in the United States has drawn attention to the possibility of occupational exposures to BSL-3 and -4 agents and has prompted a reassessment of medical management procedures and facilities to deal with these contingencies. A workshop hosted by the National Interagency Biodefense Campus was held in October 2007 and was attended by representatives of all existing and planned BSL-4 research facilities in the U.S. and Canada. This report summarizes important points of discussion and recommendations for future coordinated action, including guidelines for the engineering and operational controls appropriate for a hospital care and isolation unit. Recommendations pertained to initial management of exposures (ie, immediate treatment of penetrating injuries, reporting of exposures, initial evaluation, and triage). Isolation and medical care in a referral hospital (including minimum standards for isolation units), staff recruitment and training, and community outreach also were addressed. Workshop participants agreed that any unit designated for the isolation and treatment of laboratory employees accidentally infected with a BSL-3 or -4 pathogen should be designed to maximize the efficacy of patient care while minimizing the risk of transmission of infection. Further, participants concurred that there is no medically based rationale for building care and isolation units to standards approximating a BSL-4 laboratory. Instead, laboratory workers accidentally exposed to pathogens should be cared for in hospital isolation suites staffed by highly trained professionals following strict infection control procedures. JF - Biosecurity and Bioterrorism AU - Jahrling, P AU - Rodak, C AU - Bray, M AU - Davey, R T AD - NIAID Integrated Research Facility, 8200 Research Plaza, Frederick, MD 21702, USA, jahrlingp@niaid.nih.gov Y1 - 2009/07/27/ PY - 2009 DA - 2009 Jul 27 SP - 135 EP - 143 VL - 7 IS - 2 SN - 1538-7135, 1538-7135 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Conferences KW - Injuries KW - Training KW - bioterrorism KW - Guidelines KW - Recruitment KW - Disasters KW - Pathogens KW - Infection KW - USA KW - Canada KW - Isolation units KW - Occupational exposure KW - Contingency KW - Hospitals KW - X 24310:Pharmaceuticals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1315605630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosecurity+and+Bioterrorism&rft.atitle=Triage+and+Management+of+Accidental+Laboratory+Exposures+to+Biosafety+Level-3+and+-4+Agents&rft.au=Jahrling%2C+P%3BRodak%2C+C%3BBray%2C+M%3BDavey%2C+R+T&rft.aulast=Jahrling&rft.aufirst=P&rft.date=2009-07-27&rft.volume=7&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Biosecurity+and+Bioterrorism&rft.issn=15387135&rft_id=info:doi/10.1089%2Fbsp.2009.0002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Injuries; Conferences; bioterrorism; Recruitment; Pathogens; Isolation units; Infection; Contingency; Occupational exposure; Hospitals; Training; Guidelines; Disasters; USA; Canada DO - http://dx.doi.org/10.1089/bsp.2009.0002 ER - TY - CPAPER T1 - Interaction Of Nuclear Receptors With The Chromatin Landscape T2 - 2009 Gordon Research Conference on Hormone Action In Development & Cancer AN - 866041483; 5966134 JF - 2009 Gordon Research Conference on Hormone Action In Development & Cancer AU - Hager, Gordon Y1 - 2009/07/26/ PY - 2009 DA - 2009 Jul 26 KW - Landscape KW - Nuclear receptors KW - Chromatin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866041483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Hormone+Action+In+Development+%26+Cancer&rft.atitle=Interaction+Of+Nuclear+Receptors+With+The+Chromatin+Landscape&rft.au=Hager%2C+Gordon&rft.aulast=Hager&rft.aufirst=Gordon&rft.date=2009-07-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Hormone+Action+In+Development+%26+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=hormone LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Function of Scaffold Proteins in ERK Cascade Signaling T2 - Protein Kinases and Protein Phosphorylation AN - 40397403; 5300950 JF - Protein Kinases and Protein Phosphorylation AU - Morrison, Debbie Y1 - 2009/07/26/ PY - 2009 DA - 2009 Jul 26 KW - Signal transduction KW - Scaffolds KW - Extracellular signal-regulated kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40397403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Protein+Kinases+and+Protein+Phosphorylation&rft.atitle=Function+of+Scaffold+Proteins+in+ERK+Cascade+Signaling&rft.au=Morrison%2C+Debbie&rft.aulast=Morrison&rft.aufirst=Debbie&rft.date=2009-07-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Protein+Kinases+and+Protein+Phosphorylation&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11707.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeting Sponge-microbe Symbioses: An Unconventional Approach for Natural Products Discovery T2 - 2009 Gordon Research Conference on Natural Products AN - 40346028; 5261344 JF - 2009 Gordon Research Conference on Natural Products AU - Bewley, Carole Y1 - 2009/07/26/ PY - 2009 DA - 2009 Jul 26 KW - Natural products KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Natural+Products&rft.atitle=Targeting+Sponge-microbe+Symbioses%3A+An+Unconventional+Approach+for+Natural+Products+Discovery&rft.au=Bewley%2C+Carole&rft.aulast=Bewley&rft.aufirst=Carole&rft.date=2009-07-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Natural+Products&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=natprod LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Archaeo-eukaryotic Relationships T2 - 2009 Gordon Research Conference on Archaea: Ecology, Metabolism and Molecular Biology AN - 40326960; 5261807 JF - 2009 Gordon Research Conference on Archaea: Ecology, Metabolism and Molecular Biology AU - Koonin, Eugene Y1 - 2009/07/26/ PY - 2009 DA - 2009 Jul 26 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40326960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Archaea%3A+Ecology%2C+Metabolism+and+Molecular+Biology&rft.atitle=Archaeo-eukaryotic+Relationships&rft.au=Koonin%2C+Eugene&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2009-07-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Archaea%3A+Ecology%2C+Metabolism+and+Molecular+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=archaea LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibitory Control of the Mossy Fiber-CA3 System T2 - 2009 Gordon Research Conference on Inhibition in the Central Nervous System AN - 40316246; 5257972 JF - 2009 Gordon Research Conference on Inhibition in the Central Nervous System AU - McBain, Chris Y1 - 2009/07/26/ PY - 2009 DA - 2009 Jul 26 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40316246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Inhibition+in+the+Central+Nervous+System&rft.atitle=Inhibitory+Control+of+the+Mossy+Fiber-CA3+System&rft.au=McBain%2C+Chris&rft.aulast=McBain&rft.aufirst=Chris&rft.date=2009-07-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Inhibition+in+the+Central+Nervous+System&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=inhibition LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure of ERA in Complex with the 3? End of 16S rRNA: Implications for Ribosome Biogenesis T2 - 23rd Annual Symposium of the Protein Society AN - 40367983; 5278620 JF - 23rd Annual Symposium of the Protein Society AU - Tu, C. Y1 - 2009/07/25/ PY - 2009 DA - 2009 Jul 25 KW - Ribosomes KW - RRNA 16S KW - Biogenesis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40367983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Symposium+of+the+Protein+Society&rft.atitle=Structure+of+ERA+in+Complex+with+the+3%3F+End+of+16S+rRNA%3A+Implications+for+Ribosome+Biogenesis&rft.au=Tu%2C+C.&rft.aulast=Tu&rft.aufirst=C.&rft.date=2009-07-25&rft.volume=23&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Williston+Park%2C+N.Y.%29&rft.issn=08909091&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium23rd/pdf/WEB%20Program_06%2023% 202009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing RNA Sequence Specificity and Function of PUF Proteins T2 - 23rd Annual Symposium of the Protein Society AN - 40365406; 5278619 JF - 23rd Annual Symposium of the Protein Society AU - Hall, T Y1 - 2009/07/25/ PY - 2009 DA - 2009 Jul 25 KW - RNA KW - Nucleotide sequence KW - Specificity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40365406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Symposium+of+the+Protein+Society&rft.atitle=Probing+RNA+Sequence+Specificity+and+Function+of+PUF+Proteins&rft.au=Hall%2C+T&rft.aulast=Hall&rft.aufirst=T&rft.date=2009-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium23rd/pdf/WEB%20Program_06%2023% 202009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Dynamin Family Members in Membrane Fission T2 - 23rd Annual Symposium of the Protein Society AN - 40363768; 5278644 JF - 23rd Annual Symposium of the Protein Society AU - Hinshaw, J Y1 - 2009/07/25/ PY - 2009 DA - 2009 Jul 25 KW - Membranes KW - Dynamin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40363768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Symposium+of+the+Protein+Society&rft.atitle=The+Role+of+Dynamin+Family+Members+in+Membrane+Fission&rft.au=Hinshaw%2C+J&rft.aulast=Hinshaw&rft.aufirst=J&rft.date=2009-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium23rd/pdf/WEB%20Program_06%2023% 202009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Molecule Protein Kinetics T2 - 23rd Annual Symposium of the Protein Society AN - 40363702; 5278611 JF - 23rd Annual Symposium of the Protein Society AU - Eaton, W Y1 - 2009/07/25/ PY - 2009 DA - 2009 Jul 25 KW - Kinetics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40363702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Symposium+of+the+Protein+Society&rft.atitle=Single+Molecule+Protein+Kinetics&rft.au=Eaton%2C+W&rft.aulast=Eaton&rft.aufirst=W&rft.date=2009-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium23rd/pdf/WEB%20Program_06%2023% 202009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice. AN - 67578175; 19627616 AB - Esophago-gastroduodenal anastomosis with rats mimics the development of human Barrett's esophagus and esophageal adenocarcinoma by introducing mixed reflux of gastric and duodenal contents into the esophagus. However, use of this rat model for mechanistic and chemopreventive studies is limited due to lack of genetically modified rat strains. Therefore, a mouse model of esophageal adenocarcinoma is needed. We performed reflux surgery on wild-type, p53A135V transgenic, and INK4a/Arf+/- mice of A/J strain. Some mice were also treated with omeprazole (1,400 ppm in diet), iron (50 mg/kg/m, i.p.), or gastrectomy plus iron. Mouse esophagi were harvested at 20, 40 or 80 weeks after surgery for histopathological analysis. At week 20, we observed metaplasia in wild-type mice (5%, 1/20) and p53A135V mice (5.3%, 1/19). At week 40, metaplasia was found in wild-type mice (16.2%, 6/37), p53A135V mice (4.8%, 2/42), and wild-type mice also receiving gastrectomy and iron (6.7%, 1/15). Esophageal squamous cell carcinoma developed in INK4a/Arf+/- mice (7.1%, 1/14), and wild-type mice receiving gastrectomy and iron (21.4%, 3/14). Among 13 wild-type mice which were given iron from week 40 to 80, twelve (92.3%) developed squamous cell carcinoma at week 80. None of these mice developed esophageal adenocarcinoma. Surgically induced gastroesophageal reflux produced esophageal squamous cell carcinoma, but not esophageal adenocarcinoma, in mice. Dominant negative p53 mutation, heterozygous loss of INK4a/Arf, antacid treatment, iron supplementation, or gastrectomy failed to promote esophageal adenocarcinoma in these mice. Further studies are needed in order to develop a mouse model of esophageal adenocarcinoma. JF - BMC gastroenterology AU - Hao, Jing AU - Liu, Ba AU - Yang, Chung S AU - Chen, Xiaoxin AD - Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. haoj2@mail.nih.gov Y1 - 2009/07/23/ PY - 2009 DA - 2009 Jul 23 SP - 59 VL - 9 KW - Anti-Ulcer Agents KW - 0 KW - Cyclin-Dependent Kinase Inhibitor p16 KW - Tumor Suppressor Protein p53 KW - Iron KW - E1UOL152H7 KW - Omeprazole KW - KG60484QX9 KW - Index Medicus KW - Animals KW - Esophagus -- metabolism KW - Anti-Ulcer Agents -- adverse effects KW - Omeprazole -- adverse effects KW - Iron -- adverse effects KW - Cyclin-Dependent Kinase Inhibitor p16 -- metabolism KW - Mice KW - Mice, Transgenic KW - Tumor Suppressor Protein p53 -- metabolism KW - Mice, Knockout KW - Esophagus -- pathology KW - Loss of Heterozygosity KW - Adenocarcinoma -- etiology KW - Tumor Suppressor Protein p53 -- genetics KW - Cyclin-Dependent Kinase Inhibitor p16 -- genetics KW - Mutation KW - Female KW - Male KW - Carcinoma, Squamous Cell -- etiology KW - Gastroesophageal Reflux -- complications KW - Carcinoma, Squamous Cell -- pathology KW - Gastroesophageal Reflux -- etiology KW - Gastrectomy -- adverse effects KW - Disease Models, Animal KW - Esophageal Neoplasms -- etiology KW - Esophageal Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67578175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+gastroenterology&rft.atitle=Gastroesophageal+reflux+leads+to+esophageal+cancer+in+a+surgical+model+with+mice.&rft.au=Hao%2C+Jing%3BLiu%2C+Ba%3BYang%2C+Chung+S%3BChen%2C+Xiaoxin&rft.aulast=Hao&rft.aufirst=Jing&rft.date=2009-07-23&rft.volume=9&rft.issue=&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=BMC+gastroenterology&rft.issn=1471-230X&rft_id=info:doi/10.1186%2F1471-230X-9-59 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-21 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2003 Aug 1;63(15):4389-95 [12907609] Med Hypotheses. 2006;66(1):154-7 [16125332] Cancer Res. 2004 Mar 1;64(5):1561-9 [14996709] Lab Invest. 2004 Jun;84(6):753-65 [15094711] Int J Cancer. 2004 Aug 20;111(2):224-8 [15197775] Ann Surg. 2004 Jul;240(1):57-67 [15213619] Virchows Arch. 2004 Aug;445(2):135-41 [15185075] Clin Cancer Res. 2004 Oct 1;10(19):6703-9 [15475461] Ann Surg. 2004 Nov;240(5):817-24 [15492563] Cancer Res. 1989 Dec 1;49(23):6803-8 [2819720] Surgery. 1992 May;111(5):503-10 [1598670] J Surg Oncol. 2005 Dec 1;92(3):151-9 [16299786] J Surg Oncol. 2005 Dec 1;92(3):262-6 [16299792] World J Gastroenterol. 2005 Dec 21;11(47):7436-43 [16437713] Dis Esophagus. 2006;19(5):346-9 [16984530] Semin Radiat Oncol. 2007 Jan;17(1):2-9 [17185192] Am J Gastroenterol. 2007 Jan;102(1):10-20 [17266684] Anticancer Res. 2007 Jan-Feb;27(1A):175-81 [17352229] Development. 2007 Jul;134(13):2521-31 [17522155] Clin Cancer Res. 2007 Sep 1;13(17):5176-82 [17785574] Int J Oncol. 2007 Dec;31(6):1351-5 [17982662] Cancer Sci. 2008 Jan;99(1):7-13 [17953708] BMC Gastroenterol. 2008;8:1 [18190713] J Gastrointest Surg. 2000 May-Jun;4(3):290-7 [10769092] Carcinogenesis. 2001 Aug;22(8):1119-29 [11470739] J Thorac Cardiovasc Surg. 2001 Oct;122(4):809-14 [11581618] Surg Oncol. 2001 Nov;10(3):81-90 [11750227] Carcinogenesis. 2002 Dec;23(12):2095-102 [12507933] Acta Otorhinolaryngol Belg. 2003;57(2):113-7 [12836467] Br J Cancer. 1994 Aug;70(2):185-9 [8054264] Dysphagia. 1995 Winter;10(1):49-52 [7859534] Nat Genet. 1995 Mar;9(3):305-11 [7773294] Histochem J. 1995 Mar;27(3):231-9 [7797426] Am J Gastroenterol. 1997 Aug;92(8):1347-50 [9260804] Carcinogenesis. 1997 Nov;18(11):2265-70 [9395230] Carcinogenesis. 1998 Aug;19(8):1445-9 [9744541] J Surg Res. 1999 May 1;83(1):48-55 [10210642] Nature. 1999 Apr 22;398(6729):714-8 [10227294] Carcinogenesis. 1999 Sep;20(9):1801-8 [10469627] Am J Gastroenterol. 1999 Oct;94(10):2818-24 [10520827] Oncogene. 2005 Mar 3;24(10):1683-8 [15674336] EMBO Rep. 2003 Nov;4(11):1054-60 [14566324] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-230X-9-59 ER - TY - JOUR T1 - MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. AN - 67510365; 19597153 AB - Fifteen percent of lung cancer cases occur in never-smokers and show characteristics that are molecularly and clinically distinct from those in smokers. Epidermal growth factor receptor (EGFR) gene mutations, which are correlated with sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs), are more frequent in never-smoker lung cancers. In this study, microRNA (miRNA) expression profiling of 28 cases of never-smoker lung cancer identified aberrantly expressed miRNAs, which were much fewer than in lung cancers of smokers and included miRNAs previously identified (e.g., up-regulated miR-21) and unidentified (e.g., down-regulated miR-138) in those smoker cases. The changes in expression of some of these miRNAs, including miR-21, were more remarkable in cases with EGFR mutations than in those without these mutations. A significant correlation between phosphorylated-EGFR (p-EGFR) and miR-21 levels in lung carcinoma cell lines and the suppression of miR-21 by an EGFR-TKI, AG1478, suggest that the EGFR signaling is a pathway positively regulating miR-21 expression. In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21, antisense inhibition of miR-21 enhanced AG1478-induced apoptosis. In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR, the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself. These results suggest that aberrantly increased expression of miR-21, which is enhanced further by the activated EGFR signaling pathway, plays a significant role in lung carcinogenesis in never-smokers, as well as in smokers, and is a potential therapeutic target in both EGFR-mutant and wild-type cases. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Seike, Masahiro AU - Goto, Akiteru AU - Okano, Tetsuya AU - Bowman, Elise D AU - Schetter, Aaron J AU - Horikawa, Izumi AU - Mathe, Ewy A AU - Jen, Jin AU - Yang, Ping AU - Sugimura, Haruhiko AU - Gemma, Akihiko AU - Kudoh, Shoji AU - Croce, Carlo M AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/07/21/ PY - 2009 DA - 2009 Jul 21 SP - 12085 EP - 12090 VL - 106 IS - 29 KW - MIRN21 microRNA, human KW - 0 KW - MicroRNAs KW - Quinazolines KW - RNA, Antisense KW - Tyrphostins KW - tyrphostin AG 1478 KW - 170449-18-0 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Humans KW - Aged KW - Cell Line, Tumor KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Carcinoma, Non-Small-Cell Lung -- pathology KW - Gene Expression Profiling KW - Signal Transduction -- drug effects KW - Adult KW - Mutation -- genetics KW - Carcinoma, Non-Small-Cell Lung -- enzymology KW - Middle Aged KW - RNA, Antisense -- pharmacology KW - Tyrphostins -- pharmacology KW - Female KW - Male KW - Lung Neoplasms -- enzymology KW - Receptor, Epidermal Growth Factor -- metabolism KW - MicroRNAs -- metabolism KW - Receptor, Epidermal Growth Factor -- genetics KW - MicroRNAs -- genetics KW - Apoptosis -- drug effects KW - Lung Neoplasms -- genetics KW - Smoking -- pathology KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67510365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=The+preferential+dopamine+D3+receptor+antagonist+S33138+inhibits+cocaine+reward+and+cocaine-triggered+relapse+to+drug-seeking+behavior+in+rats.&rft.au=Peng%2C+Xiao-Qing%3BAshby%2C+Charles+R%3BSpiller%2C+Krista%3BLi%2C+Xia%3BLi%2C+Jie%3BThomasson%2C+Nitza%3BMillan%2C+Mark+J%3BMoca%C3%ABr%2C+Elisabeth%3BMu%C5%84oz%2C+Carmen%3BGardner%2C+Eliot+L%3BXi%2C+Zheng-Xiong&rft.aulast=Peng&rft.aufirst=Xiao-Qing&rft.date=2009-03-01&rft.volume=56&rft.issue=4&rft.spage=752&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=1873-7064&rft_id=info:doi/10.1016%2Fj.neuropharm.2008.12.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-25 N1 - Date created - 2009-07-22 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE14936; GEO N1 - SuppNotes - Cited By: Cancer Res. 2001 Jun 1;61(11):4350-6 [11389059] Genes Chromosomes Cancer. 2002 Aug;34(4):428-36 [12112532] Oncogene. 2002 Oct 7;21(45):6915-35 [12362274] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9 [12434020] Oncogene. 2003 Jan 16;22(2):211-9 [12527890] Carcinogenesis. 2003 Jul;24(7):1167-76 [12807729] N Engl J Med. 2004 May 20;350(21):2129-39 [15118073] Cancer Res. 2004 Jun 1;64(11):3753-6 [15172979] Science. 2004 Jun 4;304(5676):1497-500 [15118125] Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9740-4 [15210942] Nat Chem Biol. 2006 Dec;2(12):711-9 [17108989] Nat Rev Cancer. 2007 Mar;7(3):169-81 [17318210] Br J Cancer. 2007 Mar 26;96(6):857-63 [17325698] Science. 2007 May 18;316(5827):1039-43 [17463250] Cancer Res. 2007 Jun 15;67(12):5667-72 [17575133] Blood. 2007 Aug 15;110(4):1330-3 [17496199] Gastroenterology. 2007 Aug;133(2):647-58 [17681183] Cancer Res. 2007 Sep 15;67(18):8699-707 [17875710] Nat Rev Cancer. 2007 Oct;7(10):778-90 [17882278] Clin Cancer Res. 2007 Oct 1;13(19):5763-8 [17908966] Lung Cancer. 2007 Dec;58(3):392-6 [17728006] Cancer Res. 2007 Dec 1;67(23):11111-6 [18056433] Lancet. 2005 Oct 29-Nov 4;366(9496):1527-37 [16257339] Cancer Res. 2005 Nov 1;65(21):9628-32 [16266980] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Cancer Cell. 2006 Mar;9(3):189-98 [16530703] J Clin Invest. 2006 Oct;116(10):2695-706 [16906227] Methods. 2008 Jan;44(1):31-8 [18158130] JAMA. 2008 Jan 30;299(4):425-36 [18230780] Cancer Sci. 2008 Feb;99(2):280-6 [18201269] PLoS One. 2008;3(2):e1651 [18297132] Nat Protoc. 2008;3(4):563-78 [18388938] Nature. 2008 Apr 17;452(7189):896-9 [18368051] J Mol Biol. 2008 May 2;378(3):492-504 [18384814] Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13021-6 [18755890] Nat Clin Pract Oncol. 2008 Oct;5(10):610-8 [18628738] Int J Cancer. 2008 Dec 1;123(11):2480-6 [18785203] Biochem Biophys Res Commun. 2008 Nov 7;376(1):86-90 [18765229] Nature. 2008 Oct 23;455(7216):1069-75 [18948947] Lung Cancer. 2009 Nov;66(2):169-75 [19223090] Science. 2004 Aug 20;305(5687):1163-7 [15284455] Cancer Res. 2004 Oct 15;64(20):7241-4 [15492241] Science. 1991 Jul 5;253(5015):49-53 [1905840] N Engl J Med. 2005 Feb 24;352(8):786-92 [15728811] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Cell. 2005 Mar 11;120(5):635-47 [15766527] Nature. 2005 Jun 9;435(7043):834-8 [15944708] N Engl J Med. 2005 Jul 14;353(2):123-32 [16014882] Cancer Res. 2005 Jul 15;65(14):6029-33 [16024602] N Engl J Med. 2005 Oct 27;353(17):1793-801 [16251535] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0905234106 ER - TY - CPAPER T1 - Fast and Slow Cycling of Transcriptional Activators T2 - 2009 Gordon Research Conference on Chronobiology AN - 40417532; 5301560 JF - 2009 Gordon Research Conference on Chronobiology AU - McNally, James Y1 - 2009/07/19/ PY - 2009 DA - 2009 Jul 19 KW - Transcription factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40417532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroinformatics&rft.atitle=Neuroimaging+Informatics+Tools+and+Resources+Clearinghouse+%28NITRC%29+Resource+Announcement&rft.au=Luo%2C+Xiao-zhong+James%3BKennedy%2C+David+N%3BCohen%2C+Zohara&rft.aulast=Luo&rft.aufirst=Xiao-zhong&rft.date=2009-03-01&rft.volume=7&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Neuroinformatics&rft.issn=15392791&rft_id=info:doi/10.1007%2Fs12021-008-9036-8 L2 - http://www.grc.org/programs.aspx?year=2009&program=chrono LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Shaping the Endoplasmic Reticulum T2 - 2009 Gordon Research Conference on Lipids, Molecular & Cellular Biology Of Lipids AN - 40417378; 5302702 JF - 2009 Gordon Research Conference on Lipids, Molecular & Cellular Biology Of Lipids AU - Prinz, Will Y1 - 2009/07/19/ PY - 2009 DA - 2009 Jul 19 KW - Endoplasmic reticulum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40417378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Lipids%2C+Molecular+%26+Cellular+Biology+Of+Lipids&rft.atitle=Shaping+the+Endoplasmic+Reticulum&rft.au=Prinz%2C+Will&rft.aulast=Prinz&rft.aufirst=Will&rft.date=2009-07-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Lipids%2C+Molecular+%26+Cellular+Biology+Of+Lipids&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=lipids LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The role of water in protein-ligand binding T2 - 2009 Gordon Research Conference on Computer Aided Drug Design: Experiment Meets Modeling: Where Are We Now, Where Are We Going AN - 40401698; 5301794 JF - 2009 Gordon Research Conference on Computer Aided Drug Design: Experiment Meets Modeling: Where Are We Now, Where Are We Going AU - Hummer, Gerhard Y1 - 2009/07/19/ PY - 2009 DA - 2009 Jul 19 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40401698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Computer+Aided+Drug+Design%3A+Experiment+Meets+Modeling%3A+Where+Are+We+Now%2C+Where+Are+We+Going&rft.atitle=The+role+of+water+in+protein-ligand+binding&rft.au=Hummer%2C+Gerhard&rft.aulast=Hummer&rft.aufirst=Gerhard&rft.date=2009-07-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Computer+Aided+Drug+Design%3A+Experiment+Meets+Modeling%3A+Where+Are+We+Now%2C+Where+Are+We+Going&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=cadd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A PH domain in the Arf GAP ARAP1 binds PIP3 and regulates Arf GAP activity independently of recruitment to the plasma membranes T2 - Lipid Signaling Pathways in Cancer AN - 40400552; 5300843 JF - Lipid Signaling Pathways in Cancer AU - Campa, Fanny Y1 - 2009/07/19/ PY - 2009 DA - 2009 Jul 19 KW - Plasma membranes KW - PH KW - Recruitment KW - Phosphatidylinositol 3,4,5-triphosphate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40400552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Lipid+Signaling+Pathways+in+Cancer&rft.atitle=A+PH+domain+in+the+Arf+GAP+ARAP1+binds+PIP3+and+regulates+Arf+GAP+activity+independently+of+recruitment+to+the+plasma+membranes&rft.au=Campa%2C+Fanny&rft.aulast=Campa&rft.aufirst=Fanny&rft.date=2009-07-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Lipid+Signaling+Pathways+in+Cancer&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11656.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biochemical and pharmacological modulation of PKC T2 - Lipid Signaling Pathways in Cancer AN - 40398889; 5300850 JF - Lipid Signaling Pathways in Cancer AU - Blumberg, Peter Y1 - 2009/07/19/ PY - 2009 DA - 2009 Jul 19 KW - Biochemistry KW - Protein kinase C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40398889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Lipid+Signaling+Pathways+in+Cancer&rft.atitle=Biochemical+and+pharmacological+modulation+of+PKC&rft.au=Blumberg%2C+Peter&rft.aulast=Blumberg&rft.aufirst=Peter&rft.date=2009-07-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Lipid+Signaling+Pathways+in+Cancer&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11656.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biology of tick-borne spirochetes T2 - Microbial Pathogenesis: Mechanisms of Infectious Disease AN - 40295255; 5240311 JF - Microbial Pathogenesis: Mechanisms of Infectious Disease AU - Schwan, Tom Y1 - 2009/07/19/ PY - 2009 DA - 2009 Jul 19 KW - Spirochetes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40295255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Microbial+Pathogenesis%3A+Mechanisms+of+Infectious+Disease&rft.atitle=Biology+of+tick-borne+spirochetes&rft.au=Schwan%2C+Tom&rft.aulast=Schwan&rft.aufirst=Tom&rft.date=2009-07-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis%3A+Mechanisms+of+Infectious+Disease&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11706.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infusing Large-Scale Genome Sequencing into the Clinical Research Enterprise T2 - 2009 Gordon Research Conference on Human Genetics and Genomics AN - 40195074; 5184442 JF - 2009 Gordon Research Conference on Human Genetics and Genomics AU - Green, Eric Y1 - 2009/07/19/ PY - 2009 DA - 2009 Jul 19 KW - Clinical trials KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40195074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Human+Genetics+and+Genomics&rft.atitle=Infusing+Large-Scale+Genome+Sequencing+into+the+Clinical+Research+Enterprise&rft.au=Green%2C+Eric&rft.aulast=Green&rft.aufirst=Eric&rft.date=2009-07-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Human+Genetics+and+Genomics&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=humangen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fusion mechanisms in infection and secretion T2 - 2009 Gordon Research Conference on Cell-Cell Fusion AN - 40189532; 5184759 JF - 2009 Gordon Research Conference on Cell-Cell Fusion AU - Zimmerberg, Joshua Y1 - 2009/07/19/ PY - 2009 DA - 2009 Jul 19 KW - Infection KW - Secretion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40189532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Cell-Cell+Fusion&rft.atitle=Fusion+mechanisms+in+infection+and+secretion&rft.au=Zimmerberg%2C+Joshua&rft.aulast=Zimmerberg&rft.aufirst=Joshua&rft.date=2009-07-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Cell-Cell+Fusion&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=cellcell LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - De-identification of Genomics Data: Does it exist? T2 - 2009 Annual Conference of the Genetic Alliance AN - 40216760; 5194567 JF - 2009 Annual Conference of the Genetic Alliance AU - Jacobs, Kevin AU - McGuire, Amy AU - Rodriguez, Laura Y1 - 2009/07/17/ PY - 2009 DA - 2009 Jul 17 KW - Data processing KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40216760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Modulation+of+spontaneous+fMRI+activity+in+human+visual+cortex+by+behavioral+state&rft.au=Bianciardi%2C+Marta%3BFukunaga%2C+Masaki%3Bvan+Gelderen%2C+Peter%3BHorovitz%2C+Silvina+G%3Bde+Zwart%2C+Jacco+A%3BDuyn%2C+Jeff+H&rft.aulast=Bianciardi&rft.aufirst=Marta&rft.date=2009-03-01&rft.volume=45&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.10.034 L2 - http://geneticalliance.org/ws_display.asp?filter=conference09.program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapeutics for Rare and Neglected Diseases: Creating a Breakthrough Systems Process for Moving from Targets to Clinical Candidates T2 - 2009 Annual Conference of the Genetic Alliance AN - 40216674; 5194542 JF - 2009 Annual Conference of the Genetic Alliance AU - Austin, Chris Y1 - 2009/07/17/ PY - 2009 DA - 2009 Jul 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40216674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+Genetic+Alliance&rft.atitle=Therapeutics+for+Rare+and+Neglected+Diseases%3A+Creating+a+Breakthrough+Systems+Process+for+Moving+from+Targets+to+Clinical+Candidates&rft.au=Austin%2C+Chris&rft.aulast=Austin&rft.aufirst=Chris&rft.date=2009-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+Genetic+Alliance&rft.issn=&rft_id=info:doi/ L2 - http://geneticalliance.org/ws_display.asp?filter=conference09.program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Opportunities and Challenges in Orphan Disease Drug Development T2 - 2009 Annual Conference of the Genetic Alliance AN - 40216396; 5194543 JF - 2009 Annual Conference of the Genetic Alliance AU - Ashlock, Melissa Y1 - 2009/07/17/ PY - 2009 DA - 2009 Jul 17 KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40216396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+Genetic+Alliance&rft.atitle=Opportunities+and+Challenges+in+Orphan+Disease+Drug+Development&rft.au=Ashlock%2C+Melissa&rft.aulast=Ashlock&rft.aufirst=Melissa&rft.date=2009-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+Genetic+Alliance&rft.issn=&rft_id=info:doi/ L2 - http://geneticalliance.org/ws_display.asp?filter=conference09.program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unprecedented Therapeutic Opportunities for Rare and Neglected Diseases T2 - 2009 Annual Conference of the Genetic Alliance AN - 40215863; 5194540 JF - 2009 Annual Conference of the Genetic Alliance AU - Collins, Francis Y1 - 2009/07/17/ PY - 2009 DA - 2009 Jul 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40215863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+Genetic+Alliance&rft.atitle=Unprecedented+Therapeutic+Opportunities+for+Rare+and+Neglected+Diseases&rft.au=Honea%2C+Robyn%3BVerchinski%2C+Beth+A%3BPezawas%2C+Lukas%3BKolachana%2C+Bhaskar+S%3BCallicott%2C+Joseph+H%3BMattay%2C+Venkata+S%3BWeinberger%2C+Daniel+R%3BMeyer-Lindenberg%2C+Andreas&rft.aulast=Honea&rft.aufirst=Robyn&rft.date=2009-03-01&rft.volume=45&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.10.064 L2 - http://geneticalliance.org/ws_display.asp?filter=conference09.program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assays and Therapeutic Development for Rare and Neglected Diseases T2 - 2009 Annual Conference of the Genetic Alliance AN - 40215836; 5194541 JF - 2009 Annual Conference of the Genetic Alliance AU - Inglese, Jim Y1 - 2009/07/17/ PY - 2009 DA - 2009 Jul 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40215836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+Genetic+Alliance&rft.atitle=Assays+and+Therapeutic+Development+for+Rare+and+Neglected+Diseases&rft.au=Inglese%2C+Jim&rft.aulast=Inglese&rft.aufirst=Jim&rft.date=2009-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+Genetic+Alliance&rft.issn=&rft_id=info:doi/ L2 - http://geneticalliance.org/ws_display.asp?filter=conference09.program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Slicing and Dicing Comparative Effectiveness T2 - 2009 Annual Conference of the Genetic Alliance AN - 40212776; 5194564 JF - 2009 Annual Conference of the Genetic Alliance AU - Croyle, Robert AU - Crooks, Glenna AU - Mensh, Stephanie Y1 - 2009/07/17/ PY - 2009 DA - 2009 Jul 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40212776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+Genetic+Alliance&rft.atitle=Slicing+and+Dicing+Comparative+Effectiveness&rft.au=Croyle%2C+Robert%3BCrooks%2C+Glenna%3BMensh%2C+Stephanie&rft.aulast=Croyle&rft.aufirst=Robert&rft.date=2009-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+Genetic+Alliance&rft.issn=&rft_id=info:doi/ L2 - http://geneticalliance.org/ws_display.asp?filter=conference09.program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Population-based study of autoimmune conditions and the risk of specific lymphoid malignancies AN - 745642258; 13162988 AB - Some autoimmune conditions are associated with increased risk of lymphoid malignancies, but information on specific malignancy subtypes is limited. From the U.S. Surveillance Epidemiology and End Results-Medicare database, we selected 44,350 lymphoid malignancy cases (67 years) and 122,531 population-based controls. Logistic regression was used to derive odds ratios (ORs) comparing the prevalence of autoimmune conditions in cases and controls, by lymphoid malignancy subtype, adjusted for gender, age at malignancy/selection, year of malignancy/selection, race and number of physician claims. The strongest associations observed by non-Hodgkin lymphoma (NHL) subtypes were diffuse large B-cell lymphoma with rheumatoid arthritis (OR 1.4, 95%CI 1.2-1.5) and Sjogren syndrome (2.0, 1.5-2.8); T-cell lymphoma with hemolytic anemia (9.7, 4.3-22), psoriasis (3.1, 2.5-4.0), discoid lupus erythematosus (4.4, 2.3-8.4) and celiac disease (5.0, 2.4-14.); and marginal zone lymphoma with Sjogren syndrome (6.6, 4.6-9.5), systemic lupus erythematosus (2.8, 1.7-4.7) and hemolytic anemia (7.4, 3.1-18). Hodgkin lymphoma was associated with systemic lupus erythematosus (3.5, 1.9-6.7). Multiple myeloma was associated only with pernicious anemia (1.5, 1.3-1.7). Several autoimmune conditions were associated with increased risk of lymphoid neoplasms, especially NHLs of diffuse large B-cell, marginal zone and T-cell subtypes. These results support a mechanism whereby chronic antigenic stimulation leads to lymphoid malignancy. Published 2009 UICC. JF - International Journal of Cancer AU - Anderson, Lesley A AU - Gadalla, Shahinaz AU - Morton, Lindsay M AU - Landgren, Ola AU - Pfeiffer, Ruth AU - Warren, Joan L AU - Berndt, Sonja I AU - Ricker, Winnie AU - Parsons, Ruth AU - Engels, Eric A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, engelse@mail.nih.gov Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 398 EP - 405 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 125 IS - 2 SN - 0020-7136, 0020-7136 KW - Immunology Abstracts; Risk Abstracts KW - non-Hodgkin's lymphoma KW - Age KW - anemia KW - Hodgkin's disease KW - psoriasis KW - Autoimmune diseases KW - Pernicious anemia KW - Sjogren's syndrome KW - Malignancy KW - Multiple myeloma KW - Psoriasis KW - Lymphocytes T KW - Systemic lupus erythematosus KW - B-cell lymphoma KW - Hemolytic anemia KW - multiple myeloma KW - Lymphocytes B KW - Celiac disease KW - Population studies KW - Cancer KW - Databases KW - USA KW - Rheumatoid arthritis KW - Epidemiology KW - rheumatoid arthritis KW - Gender KW - Discoid lupus erythematosus KW - T-cell lymphoma KW - lymphoma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745642258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Population-based+study+of+autoimmune+conditions+and+the+risk+of+specific+lymphoid+malignancies&rft.au=Anderson%2C+Lesley+A%3BGadalla%2C+Shahinaz%3BMorton%2C+Lindsay+M%3BLandgren%2C+Ola%3BPfeiffer%2C+Ruth%3BWarren%2C+Joan+L%3BBerndt%2C+Sonja+I%3BRicker%2C+Winnie%3BParsons%2C+Ruth%3BEngels%2C+Eric+A&rft.aulast=Anderson&rft.aufirst=Lesley&rft.date=2009-07-15&rft.volume=125&rft.issue=2&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24287 L2 - http://www3.interscience.wiley.com/journal/121655446/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - B-cell lymphoma; Hodgkin's disease; Hemolytic anemia; Lymphocytes B; Autoimmune diseases; Celiac disease; Population studies; Pernicious anemia; Sjogren's syndrome; Databases; Malignancy; Rheumatoid arthritis; Multiple myeloma; Epidemiology; Psoriasis; Discoid lupus erythematosus; Lymphocytes T; Systemic lupus erythematosus; T-cell lymphoma; non-Hodgkin's lymphoma; Age; anemia; multiple myeloma; rheumatoid arthritis; Gender; psoriasis; lymphoma; Cancer; USA DO - http://dx.doi.org/10.1002/ijc.24287 ER - TY - JOUR T1 - Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. AN - 67497101; 19584284 AB - The precise role of transforming growth factor (TGF)-beta signaling in head and neck squamous cell carcinoma (SCC) is not yet fully understood. Here, we report generation of an inducible head- and neck-specific knockout mouse model by crossing TGF-beta receptor I (Tgfbr1) floxed mice with K14-CreER(tam) mice. By applying tamoxifen to oral cavity of the mouse to induce Cre expression, we were able to conditionally delete Tgfbr1 in the mouse head and neck epithelia. On tumor induction with 7,12-dimethylbenz(a)anthracene (DMBA), 45% of Tgfbr1 conditional knockout (cKO) mice (n = 42) developed SCCs in the head and neck area starting from 16 weeks after treatment. However, no tumors were observed in the control littermates. A molecular analysis revealed an enhanced proliferation and loss of apoptosis in the basal layer of the head and neck epithelia of Tgfbr1 cKO mice 4 weeks after tamoxifen and DMBA treatment. The most notable finding of our study is that the phosphoinositide 3-kinase (PI3K)/Akt pathway was activated in SCCs that developed in the Tgfbr1 cKO mice on inactivation of TGF-beta signaling through Smad2/3 and DMBA treatment. These observations suggest that activation of Smad-independent pathways may contribute cooperatively with inactivation of Smad-dependent pathways to promote head and neck carcinogenesis in these mice. Our results revealed the critical role of the TGF-beta signaling pathway and its cross-talk with the PI3K/Akt pathway in suppressing head and neck carcinogenesis. JF - Cancer research AU - Bian, Yansong AU - Terse, Anita AU - Du, Juan AU - Hall, Bradford AU - Molinolo, Alfredo AU - Zhang, Pin AU - Chen, Wanjun AU - Flanders, Kathleen C AU - Gutkind, J Silvio AU - Wakefield, Lalage M AU - Kulkarni, Ashok B AD - Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4330, USA. Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 5918 EP - 5926 VL - 69 IS - 14 KW - Receptors, Transforming Growth Factor beta KW - 0 KW - Transforming Growth Factor beta KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - TGF-beta type I receptor KW - EC 2.7.1.11 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Proto-Oncogene Proteins c-akt KW - Index Medicus KW - Animals KW - Apoptosis KW - Enzyme Activation KW - Head and Neck Neoplasms -- pathology KW - Carcinoma, Squamous Cell -- metabolism KW - Mice KW - Cell Proliferation KW - Models, Biological KW - Mice, Knockout KW - Gene Deletion KW - Blotting, Western KW - Head and Neck Neoplasms -- metabolism KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- genetics KW - Head and Neck Neoplasms -- genetics KW - Transforming Growth Factor beta -- metabolism KW - Immunohistochemistry KW - Cell Cycle KW - Male KW - Female KW - Receptors, Transforming Growth Factor beta -- genetics KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Protein-Serine-Threonine Kinases -- metabolism KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Receptors, Transforming Growth Factor beta -- metabolism KW - Protein-Serine-Threonine Kinases -- genetics KW - Epithelium -- metabolism KW - Epithelium -- pathology KW - Signal Transduction KW - Epithelium -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67497101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Progressive+tumor+formation+in+mice+with+conditional+deletion+of+TGF-beta+signaling+in+head+and+neck+epithelia+is+associated+with+activation+of+the+PI3K%2FAkt+pathway.&rft.au=Bian%2C+Yansong%3BTerse%2C+Anita%3BDu%2C+Juan%3BHall%2C+Bradford%3BMolinolo%2C+Alfredo%3BZhang%2C+Pin%3BChen%2C+Wanjun%3BFlanders%2C+Kathleen+C%3BGutkind%2C+J+Silvio%3BWakefield%2C+Lalage+M%3BKulkarni%2C+Ashok+B&rft.aulast=Bian&rft.aufirst=Yansong&rft.date=2009-07-15&rft.volume=69&rft.issue=14&rft.spage=5918&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-4623 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-25 N1 - Date created - 2009-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1999 Jul 15;59(14):3379-86 [10416598] Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8551-6 [10411913] Cell. 2005 May 6;121(3):335-48 [15882617] JAMA. 2005 Oct 5;294(13):1634-46 [16204663] Annu Rev Cell Dev Biol. 2005;21:659-93 [16212511] Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):41-58 [16310402] Genes Dev. 2006 May 15;20(10):1331-42 [16702406] FEBS Lett. 2006 May 22;580(12):2811-20 [16678165] Adv Immunol. 2006;90:1-50 [16730260] Nature. 2006 Jun 22;441(7096):1015-9 [16791201] Nat Rev Cancer. 2006 Jul;6(7):506-20 [16794634] Genes Dev. 2006 Nov 15;20(22):3147-60 [17114585] Cancer Lett. 2007 Jan 8;245(1-2):163-70 [16478646] Cell Cycle. 2007 Jun 1;6(11):1360-6 [17534148] Cancer Cell. 2007 Oct;12(4):313-27 [17936557] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Cancer Res. 2008 Mar 15;68(6):1809-19 [18339861] Cancer Res. 2008 May 1;68(9):3152-60 [18451140] Nat Immunol. 2008 Jun;9(6):632-40 [18438410] Cell. 2008 Jul 25;134(2):215-30 [18662538] Mol Cell Biol. 2008 Nov;28(22):6889-902 [18794361] Cancer Prev Res (Phila). 2009 Jan;2(1):27-36 [19139015] Am J Otolaryngol. 2009 Mar-Apr;30(2):89-94 [19239949] Oral Oncol. 2009 Apr-May;45(4-5):324-34 [18805044] EMBO J. 2002 Apr 2;21(7):1743-53 [11927558] Prostate. 2002 Jun 1;51(4):268-75 [11987155] Anticancer Res. 2002 Sep-Oct;22(5):2733-40 [12529989] J Pathol. 2003 Jul;200(4):429-47 [12845611] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8430-5 [12808151] Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8621-3 [12861075] Hum Mutat. 2003 Sep;22(3):183-98 [12938083] J Clin Invest. 2003 Oct;112(7):1116-24 [14523048] Nature. 2003 Oct 9;425(6958):577-84 [14534577] Oncol Res. 2003;14(2):61-73 [14649540] Science. 2004 Feb 6;303(5659):848-51 [14764882] Br J Cancer. 2004 Feb 23;90(4):822-32 [14970860] Int J Cancer. 2004 Jun 10;110(2):170-6 [15069677] Cancer Cell. 2004 Apr;5(4):311-6 [15093538] EMBO J. 2001 Apr 2;20(7):1663-73 [11285230] Mutat Res. 2001 Aug 8;479(1-2):131-9 [11470488] Int J Cancer. 2001 Sep 1;93(5):653-61 [11477574] Adv Cancer Res. 2001;83:1-54 [11665716] Cancer Res. 2004 Jul 1;64(13):4405-10 [15231647] Cancer Res. 2004 Jul 15;64(14):4687-92 [15256431] Int J Cancer. 2004 Nov 20;112(4):545-53 [15382034] N Engl J Med. 1991 Jan 3;324(1):1-8 [1701519] Cancer Res. 1999 Jun 15;59(12):2861-8 [10383147] Clin Cancer Res. 1999 Jun;5(6):1369-79 [10389921] Science. 2005 Mar 11;307(5715):1603-9 [15761148] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-4623 ER - TY - JOUR T1 - Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands. AN - 67496133; 19584147 AB - The study aims to evaluate if human keratinocyte growth factor (hKGF), secreted after transduction of murine salivary glands with adenoviral vectors, can prevent oral mucositis resulting from radiation. Two serotype 5 adenoviral vectors encoding hKGF were constructed: AdEF1alpha-hKGF and AdLTR(2)EF1alpha-hKGF. Female C3H mice, 8 weeks old, were irradiated by single (22.5 Gy) or fractionated (5 x 8 Gy for 5 days) doses to induce oral mucositis (ulcers on tongue). One day before irradiation, the above viral vectors or an empty vector, Adcontrol, was given (10(10) particles per gland) to both submandibular glands by retrograde ductal instillation. Each experiment included five groups: no irradiation and irradiation (+/-Adcontrol, AdEF1alpha-hKGF, or AdLTR(2)EF1alpha-hKGF). Blood, saliva, submandibular glands, and tongue were collected on day 7 for single-dose studies or day 10 for fractionated dosing. hKGF levels were measured by ELISA. In three separate single-dose irradiation experiments, lingual ulcers were dramatically reduced after either KGF-expressing vector. Similarly, in two separate fractionated irradiation experiments, the hKGF-expressing vectors completely prevented ulcer formation. QPCR data indicated that approximately 10(7) to 10(8) particles of each vector remained in the targeted submandibular glands at the terminal time. Transgenic hKGF protein was found at high levels in saliva, serum, and submandibular gland extracts. hKGF gene transfer to salivary glands prevented radiation-induced oral mucositis in mice. This proof of concept study suggests that transgenic hKGF secreted from transduced salivary glands may be useful clinically to prevent oral mucositis caused by radiation. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Zheng, Changyu AU - Cotrim, Ana P AU - Sunshine, Abraham N AU - Sugito, Takayuki AU - Liu, Lina AU - Sowers, Anastasia AU - Mitchell, James B AU - Baum, Bruce J AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 4641 EP - 4648 VL - 15 IS - 14 SN - 1078-0432, 1078-0432 KW - DNA, Complementary KW - 0 KW - FGF7 protein, human KW - Fibroblast Growth Factor 7 KW - 126469-10-1 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - DNA, Complementary -- genetics KW - Saliva -- chemistry KW - Humans KW - Transduction, Genetic KW - Mice, Inbred C3H KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Genetic Vectors -- genetics KW - Female KW - Cell Line KW - Adenoviridae -- genetics KW - Radiation Injuries, Experimental -- complications KW - Submandibular Gland -- pathology KW - Submandibular Gland -- radiation effects KW - Submandibular Gland -- metabolism KW - Stomatitis -- etiology KW - Genetic Therapy -- methods KW - Fibroblast Growth Factor 7 -- genetics KW - Fibroblast Growth Factor 7 -- blood KW - Stomatitis -- pathology KW - Fibroblast Growth Factor 7 -- metabolism KW - Radiation Injuries, Experimental -- prevention & control KW - Stomatitis -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67496133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Prevention+of+radiation-induced+oral+mucositis+after+adenoviral+vector-mediated+transfer+of+the+keratinocyte+growth+factor+cDNA+to+mouse+submandibular+glands.&rft.au=Zheng%2C+Changyu%3BCotrim%2C+Ana+P%3BSunshine%2C+Abraham+N%3BSugito%2C+Takayuki%3BLiu%2C+Lina%3BSowers%2C+Anastasia%3BMitchell%2C+James+B%3BBaum%2C+Bruce+J&rft.aulast=Zheng&rft.aufirst=Changyu&rft.date=2009-07-15&rft.volume=15&rft.issue=14&rft.spage=4641&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-0819 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-28 N1 - Date created - 2009-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gene Ther. 1997 Mar;4(3):258-63 [9135740] Cancer. 2004 May 1;100(9 Suppl):2026-46 [15108223] Int J Radiat Biol. 1999 May;75(5):609-20 [10374943] Int J Radiat Oncol Biol Phys. 2004 Dec 1;60(5):1520-9 [15590184] Curr Opin Oncol. 2005 May;17(3):236-40 [15818167] Int J Cancer. 2005 Sep 1;116(3):464-70 [15800945] Clin Cancer Res. 2005 Jul 15;11(14):5121-7 [16033826] Mol Ther. 2005 Sep;12(3):528-36 [16099414] CA Cancer J Clin. 2006 Mar-Apr;56(2):106-30 [16514137] J Natl Cancer Inst. 2006 Jun 21;98(12):812-24 [16788155] Hum Gene Ther. 2007 Feb;18(2):130-41 [17328680] J Surg Res. 2007 May 15;139(2):222-8 [17292422] J Gene Med. 2007 Sep;9(9):779-87 [17654745] J Invest Dermatol. 2008 Jun;128(6):1565-75 [18185534] J Clin Oncol. 2008 May 20;26(15):2489-96 [18487568] Mol Ther. 2008 Jun;16(6):1089-97 [18388914] Mol Cancer Res. 2008 Aug;6(8):1337-46 [18708365] Cancer. 2008 Nov 15;113(10):2704-13 [18973181] Semin Radiat Oncol. 2009 Jan;19(1):29-34 [19028343] Cancer Nurs. 2009 Jan-Feb;32(1):82-7 [19104205] Hum Gene Ther. 2008 Dec;19(12):1401-5 [18764738] Oral Oncol. 1999 Sep;35(5):453-70 [10694945] Genome Biol. 2001;2(3):REVIEWS3005 [11276432] Int Rev Cytol. 2002;213:93-146 [11837896] Cell Prolif. 2002 Aug;35 Suppl 1:86-92 [12139711] Oncol Nurs Forum. 2002 Aug;29(7):1063-80 [12183755] J Dent Educ. 2002 Aug;66(8):903-11 [12214838] Oncology. 2002;63 Suppl 2:2-10 [12466639] Biol Blood Marrow Transplant. 2003 Jul;9(7):443-52 [12869958] Head Neck. 2003 Dec;25(12):1057-70 [14648865] Adv Cancer Res. 2004;91:69-136 [15327889] J Gen Virol. 1977 Jul;36(1):59-74 [886304] Proc Natl Acad Sci U S A. 1989 Feb;86(3):802-6 [2915979] J Oral Pathol Med. 1989 Apr;18(4):206-13 [2769593] Science. 1989 Aug 18;245(4919):752-5 [2475908] Science. 1991 Jan 4;251(4989):72-5 [1846048] J Invest Dermatol. 1993 Jul;101(1):49-53 [8331296] J Clin Invest. 1994 Nov;94(5):1764-77 [7962522] Hum Gene Ther. 1996 Jun 10;7(9):1085-93 [8773510] Hum Gene Ther. 1996 Nov 10;7(17):2177-84 [8934231] Am J Pathol. 1996 Dec;149(6):1963-70 [8952531] Nat Rev Cancer. 2004 Apr;4(4):277-84 [15057287] Cancer. 2004 May 1;100(9 Suppl):1995-2025 [15108222] Cancer Res. 1998 Mar 1;58(5):933-9 [9500453] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-0819 ER - TY - JOUR T1 - Genomic characterization of esophageal squamous cell carcinoma from a high-risk population in China. AN - 67496046; 19584285 AB - Genomic instability plays an important role in most human cancers. To characterize genomic instability in esophageal squamous cell carcinoma (ESCC), we examined loss of heterozygosity (LOH), copy number (CN) loss, CN gain, and gene expression using the Affymetrix GeneChip Human Mapping 500K (n = 30 cases) and Human U133A (n = 17 cases) arrays in ESCC cases from a high-risk region of China. We found that genomic instability measures varied widely among cases and separated them into two groups: a high-frequency instability group (two-thirds of all cases with one or more instability category of > or =10%) and a low-frequency instability group (one-third of cases with instability of <10%). Genomic instability also varied widely across chromosomal arms, with the highest frequency of LOH on 9p (33% of informative single nucleotide polymorphisms), CN loss on 3p (33%), and CN gain on 3q (48%). Twenty-two LOH regions were identified: four on 9p, seven on 9q, four on 13q, two on 17p, and five on 17q. Three CN loss regions-3p12.3, 4p15.1, and 9p21.3-were detected. Twelve CN gain regions were found, including six on 3q, one on 7q, four on 8q, and one on 11q. One of the most gene-rich of these CN gain regions was 11q13.1-13.4, where 26 genes also had RNA expression data available. CN gain was significantly correlated with increased RNA expression in over 80% of these genes. Our findings show the potential utility of combining CN analysis and gene expression data to identify genes involved in esophageal carcinogenesis. JF - Cancer research AU - Hu, Nan AU - Wang, Chaoyu AU - Ng, David AU - Clifford, Robert AU - Yang, Howard H AU - Tang, Ze-Zhong AU - Wang, Quan-Hong AU - Han, Xiao-You AU - Giffen, Carol AU - Goldstein, Alisa M AU - Taylor, Philip R AU - Lee, Maxwell P AD - Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892-7236, USA. Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 5908 EP - 5917 VL - 69 IS - 14 KW - RNA, Messenger KW - 0 KW - Index Medicus KW - Gene Frequency KW - Humans KW - Oligonucleotide Array Sequence Analysis -- methods KW - Aged KW - RNA, Messenger -- genetics KW - Asian Continental Ancestry Group -- genetics KW - Chromosome Mapping KW - Gene Expression Profiling KW - Loss of Heterozygosity KW - RNA, Messenger -- metabolism KW - Genomic Instability KW - Risk Factors KW - Adult KW - Chromosome Aberrations KW - Middle Aged KW - Gene Dosage KW - Male KW - China KW - Female KW - Carcinoma, Squamous Cell -- ethnology KW - Esophageal Neoplasms -- ethnology KW - Genome, Human -- genetics KW - Esophageal Neoplasms -- genetics KW - Carcinoma, Squamous Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67496046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Genomic+characterization+of+esophageal+squamous+cell+carcinoma+from+a+high-risk+population+in+China.&rft.au=Hu%2C+Nan%3BWang%2C+Chaoyu%3BNg%2C+David%3BClifford%2C+Robert%3BYang%2C+Howard+H%3BTang%2C+Ze-Zhong%3BWang%2C+Quan-Hong%3BHan%2C+Xiao-You%3BGiffen%2C+Carol%3BGoldstein%2C+Alisa+M%3BTaylor%2C+Philip+R%3BLee%2C+Maxwell+P&rft.aulast=Hu&rft.aufirst=Nan&rft.date=2009-07-15&rft.volume=69&rft.issue=14&rft.spage=5908&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-4622 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-25 N1 - Date created - 2009-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Genet. 2006 Nov;7(11):862-72 [17047685] Genes Chromosomes Cancer. 2006 Nov;45(11):1018-32 [16897747] Nat Genet. 2006 Dec;38(12):1386-96 [17099711] BMC Genomics. 2006;7:299 [17134496] Nat Genet. 2007 Feb;39(2):226-31 [17206142] Oncologist. 2007 Apr;12(4):406-17 [17470683] Oncol Rep. 2007 Aug;18(2):465-72 [17611672] Genes Chromosomes Cancer. 2008 Apr;47(4):353-62 [18196592] World J Gastroenterol. 2008 Mar 28;14(12):1828-35 [18350619] Int J Cancer. 2008 May 15;122(10):2249-54 [18241037] BMC Cancer. 2008;8:98 [18405350] Cancer Res. 2008 May 15;68(10):3558-60; discussion 3560-1 [18483234] Clin Cancer Res. 1999 Nov;5(11):3476-82 [10589761] Genes Chromosomes Cancer. 2000 Mar;27(3):217-28 [10679910] Carcinogenesis. 2000 Nov;21(11):2019-26 [11062163] Science. 2002 Aug 16;297(5584):1143 [12183620] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12963-8 [12297621] Bioinformatics. 2003 Jan 22;19(2):185-93 [12538238] Cancer Res. 2003 Jul 15;63(14):3872-6 [12873975] Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Feb;23(1):10-4 [12905809] Biostatistics. 2003 Apr;4(2):249-64 [12925520] Genes Chromosomes Cancer. 2004 Mar;39(3):205-16 [14732922] Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8715-20 [15155901] Natl Cancer Inst Monogr. 1982;62:113-20 [7167171] Science. 1996 Nov 8;274(5289):998-1001 [8875945] Nature. 1998 Dec 17;396(6712):643-9 [9872311] Genes Chromosomes Cancer. 1999 Apr;24(4):337-44 [10092132] Oncogene. 2005 Mar 3;24(10):1794-801 [15688027] Genes Chromosomes Cancer. 2005 Sep;44(1):37-51 [15929091] Genes Chromosomes Cancer. 2005 Nov;44(3):271-8 [16015646] Blood. 2006 Sep 1;108(5):1733-43 [16705090] Cancer Lett. 2008 Jul 8;265(2):157-66 [18406052] Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1424-35 [18559558] Int J Cancer. 2008 Oct 1;123(7):1610-5 [18649358] Genes Chromosomes Cancer. 2009 Jan;48(1):55-68 [18828157] J Pathol. 2008 Dec;216(4):471-82 [18798223] Genes Chromosomes Cancer. 2006 Nov;45(11):1033-40 [16897746] Dis Esophagus. 2006;19(6):459-67 [17069589] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-4622 ER - TY - JOUR T1 - Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. AN - 67491595; 19602690 AB - With improvements in supportive care, both long-term survival following allogeneic hematopoietic stem cell transplantations (HSCTs) and the indications for this procedure have increased. As a result, the number of patients living with long-term toxic effects due to HSCT has increased. A once rare condition of the donor immune cells attacking healthy host tissues, termed chronic graft-vs-host disease, has become a more common phenomenon. When chronic graft-vs-host disease affects the lung tissue, bronchiolitis obliterans syndrome ensues. Recent data suggest that bronchiolitis obliterans syndrome may affect up to 6% of HSCT recipients and dramatically alters survival, with overall survival of only 13% at 5 years. These statistics have not improved since the first presentation of this disease over 20 years ago. Challenges to the progress of medical management of bronchiolitis obliterans syndrome include difficulties and delays in diagnosis and a paucity of data on pathogenesis to direct new therapies. This article critically evaluates the current diagnostic criteria for bronchiolitis obliterans syndrome and reviews the epidemiology, pathogenesis, and available treatments. Improvements in survival will likely require early disease recognition, allowing for therapeutic modulation of disease prior to the development of irreversible airway obliteration. JF - JAMA AU - Williams, Kirsten M AU - Chien, Jason W AU - Gladwin, Mark T AU - Pavletic, Steven Z AD - Experimental Transplantation and Immunology Branch, National Cancer Institute, Bldg 10 CRC, Room 3-3288, 10 Center Dr, Bethesda, MD 20892, USA. williaki@mail.nih.gov Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 306 EP - 314 VL - 302 IS - 3 KW - Immunosuppressive Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Respiratory Function Tests KW - Humans KW - Tomography, X-Ray Computed KW - Transplantation, Homologous KW - Biopsy, Needle KW - Adolescent KW - Immunosuppressive Agents -- therapeutic use KW - Female KW - Bronchiolitis Obliterans -- diagnosis KW - Bronchiolitis Obliterans -- epidemiology KW - Bronchiolitis Obliterans -- therapy KW - Bronchiolitis Obliterans -- etiology KW - Hematopoietic Stem Cell Transplantation -- adverse effects KW - Graft vs Host Disease -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67491595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Bronchiolitis+obliterans+after+allogeneic+hematopoietic+stem+cell+transplantation.&rft.au=Williams%2C+Kirsten+M%3BChien%2C+Jason+W%3BGladwin%2C+Mark+T%3BPavletic%2C+Steven+Z&rft.aulast=Williams&rft.aufirst=Kirsten&rft.date=2009-07-15&rft.volume=302&rft.issue=3&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/10.1001%2Fjama.2009.1018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-23 N1 - Date created - 2009-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/jama.2009.1018 ER - TY - JOUR T1 - Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. AN - 67487320; 19540764 AB - Here, we report the results of a quantitative high-throughput screen (qHTS) measuring the endocytosis and translocation of a beta-lactamase-fused-lethal factor and the identification of small molecules capable of obstructing the process of anthrax toxin internalization. Several small molecules protect RAW264.7 macrophages and CHO cells from anthrax lethal toxin and protected cells from an LF-Pseudomonas exotoxin fusion protein and diphtheria toxin. Further efforts demonstrated that these compounds impaired the PA heptamer pre-pore to pore conversion in cells expressing the CMG2 receptor, but not the related TEM8 receptor, indicating that these compounds likely interfere with toxin internalization. JF - Bioorganic & medicinal chemistry AU - Zhu, Ping Jun AU - Hobson, John P AU - Southall, Noel AU - Qiu, Cunping AU - Thomas, Craig J AU - Lu, Jiamo AU - Inglese, James AU - Zheng, Wei AU - Leppla, Stephen H AU - Bugge, Thomas H AU - Austin, Christopher P AU - Liu, Shihui AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States. Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 5139 EP - 5145 VL - 17 IS - 14 KW - Anti-Bacterial Agents KW - 0 KW - Antigens, Bacterial KW - Bacterial Proteins KW - Bacterial Toxins KW - Diphtheria Toxin KW - Exotoxins KW - Small Molecule Libraries KW - anthrax toxin KW - Index Medicus KW - Macrophages -- cytology KW - Animals KW - Cricetulus KW - Exotoxins -- antagonists & inhibitors KW - Corynebacterium diphtheriae -- metabolism KW - Bacterial Proteins -- metabolism KW - Diphtheria Toxin -- metabolism KW - Mice KW - Diphtheria Toxin -- antagonists & inhibitors KW - Macrophages -- drug effects KW - Cell Death -- drug effects KW - Bacterial Proteins -- antagonists & inhibitors KW - Exotoxins -- metabolism KW - CHO Cells KW - Pseudomonas -- metabolism KW - Cricetinae KW - Bacillus anthracis -- drug effects KW - Bacterial Toxins -- antagonists & inhibitors KW - Bacterial Toxins -- metabolism KW - Antigens, Bacterial -- metabolism KW - Small Molecule Libraries -- pharmacology KW - Anti-Bacterial Agents -- chemistry KW - Endocytosis -- drug effects KW - Bacillus anthracis -- metabolism KW - Anti-Bacterial Agents -- pharmacology KW - Anthrax -- drug therapy KW - Small Molecule Libraries -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67487320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Quantitative+high-throughput+screening+identifies+inhibitors+of+anthrax-induced+cell+death.&rft.au=Zhu%2C+Ping+Jun%3BHobson%2C+John+P%3BSouthall%2C+Noel%3BQiu%2C+Cunping%3BThomas%2C+Craig+J%3BLu%2C+Jiamo%3BInglese%2C+James%3BZheng%2C+Wei%3BLeppla%2C+Stephen+H%3BBugge%2C+Thomas+H%3BAustin%2C+Christopher+P%3BLiu%2C+Shihui&rft.aulast=Zhu&rft.aufirst=Ping&rft.date=2009-07-15&rft.volume=17&rft.issue=14&rft.spage=5139&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=1464-3391&rft_id=info:doi/10.1016%2Fj.bmc.2009.05.054 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-08 N1 - Date created - 2009-07-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 2004 Jul;48(7):2693-6 [15215127] Curr Opin Microbiol. 2004 Feb;7(1):19-24 [15036135] J Med Chem. 1992 Mar 20;35(6):994-1001 [1552513] Invest New Drugs. 1996;14(4):409-13 [9157078] J Virol. 1998 Dec;72(12):9645-55 [9811698] Science. 2004 Nov 12;306(5699):1138-9 [15542455] Nat Biotechnol. 2005 Jun;23(6):725-30 [15895075] Science. 2005 Jun 10;308(5728):1643-5 [15831716] J Med Chem. 2005 Jun 30;48(13):4469-73 [15974598] Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13278-83 [16141341] Trends Biochem Sci. 2006 Feb;31(2):123-33 [16406634] Cell. 2006 Feb 24;124(4):729-40 [16497584] Nat Methods. 2006 Apr;3(4):259-61 [16554829] Chem Rev. 2006 Jun;106(6):2476-530 [16771457] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Cell Microbiol. 2007 Apr;9(4):977-87 [17381430] J Biol Chem. 2007 Mar 30;282(13):9834-45 [17251181] Nat Chem Biol. 2007 Aug;3(8):466-79 [17637779] Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11 [17485504] J Med Chem. 2007 Aug 23;50(17):4087-95 [17663539] J Bone Miner Res. 2007 Oct;22(10):1640-8 [17576165] Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4346-51 [18334631] J Biol Chem. 2001 May 25;276(21):17976-84 [11278833] J Biol Chem. 2003 Feb 14;278(7):5227-34 [12468536] Mol Cell. 2003 Sep;12(3):603-13 [14527407] Mol Cell Biol. 2004 Nov;24(21):9487-97 [15485916] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bmc.2009.05.054 ER - TY - JOUR T1 - Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome. AN - 67458417; 19561097 AB - CD3-specific Ab therapy results in a transient, self-limiting, cytokine-associated, flu-like syndrome in experimental animals and in patients, but the underlying mechanism for this spontaneous resolution remains elusive. By using an in vivo model of CD3-specific Ab-induced flu-like syndrome, we show in this paper that a single injection of sublethal dose of the Ab killed all TGF-beta1(-/-) mice. The death of TGF-beta1(-/-) mice was associated with occurrence of this uncontrolled flu-like syndrome, as demonstrated by a sustained storm of systemic inflammatory TNF and IFN-gamma cytokines. We present evidence that deficiency of professional phagocytes to produce TGF-beta1 after apoptotic T cell clearance may be responsible, together with hypersensitivity of T cells to both activation and apoptosis, for the uncontrolled inflammation. These findings indicate a key role for TGF-beta1 and phagocytes in protecting the recipients from lethal inflammation and resolving the flu-like syndrome after CD3-specific Ab treatment. The study may also provide a novel molecular mechanism explaining the early death in TGF-beta1(-/-) mice. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Perruche, Sylvain AU - Zhang, Pin AU - Maruyama, Takashi AU - Bluestone, Jeffrey A AU - Saas, Philippe AU - Chen, WanJun AD - Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 953 EP - 961 VL - 183 IS - 2 KW - Antibodies KW - 0 KW - Antigens, CD3 KW - Cytokines KW - Transforming Growth Factor beta1 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Phagocytes -- pathology KW - Apoptosis KW - Syndrome KW - Cytokines -- secretion KW - Mice KW - T-Lymphocytes -- pathology KW - Time Factors KW - Cause of Death KW - Mice, Knockout KW - Antigens, CD3 -- immunology KW - Antibodies -- therapeutic use KW - Transforming Growth Factor beta1 -- immunology KW - Inflammation -- chemically induced KW - Inflammation -- etiology KW - Inflammation -- immunology KW - Transforming Growth Factor beta1 -- genetics KW - Antibodies -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67458417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Lethal+effect+of+CD3-specific+antibody+in+mice+deficient+in+TGF-beta1+by+uncontrolled+flu-like+syndrome.&rft.au=Perruche%2C+Sylvain%3BZhang%2C+Pin%3BMaruyama%2C+Takashi%3BBluestone%2C+Jeffrey+A%3BSaas%2C+Philippe%3BChen%2C+WanJun&rft.aulast=Perruche&rft.aufirst=Sylvain&rft.date=2009-07-15&rft.volume=183&rft.issue=2&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.0804076 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-15 N1 - Date created - 2009-07-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 2003 Dec 15;198(12):1875-86 [14676299] Nat Med. 2003 Sep;9(9):1202-8 [12937416] Nature. 1988 Jul 21;334(6179):260-2 [3041283] J Immunol. 1989 Feb 1;142(3):737-43 [2521507] Transplantation. 1989 Apr;47(4):606-8 [2523100] N Engl J Med. 1989 May 25;320(21):1420-1 [2785642] JAMA. 1989 Aug 18;262(7):938-41 [2666683] Eur J Immunol. 1990 Mar;20(3):509-15 [2138557] Eur J Immunol. 1990 Mar;20(3):707-10 [2138564] J Exp Med. 1992 Nov 1;176(5):1355-64 [1383385] Nature. 1992 Oct 22;359(6397):693-9 [1436033] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):770-4 [8421714] Nature. 1993 Aug 26;364(6440):806-9 [7689176] J Exp Med. 1994 Apr 1;179(4):1285-95 [7908323] J Clin Invest. 1994 May;93(5):2189-96 [8182150] J Immunol. 1994 Sep 1;153(5):1936-46 [8051399] Science. 1994 Aug 26;265(5176):1237-40 [7520605] J Exp Med. 1994 Nov 1;180(5):1587-90 [7964446] Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12215-9 [8618872] J Clin Invest. 1996 Nov 1;98(9):2109-19 [8903331] Immunol Today. 1997 Feb;18(2):61-4 [9057354] Immunol Today. 1997 Jul;18(7):335-43 [9238837] J Clin Invest. 1998 Feb 15;101(4):890-8 [9466984] Annu Rev Immunol. 1998;16:137-61 [9597127] Cell Death Differ. 2006 Jan;13(1):41-52 [15962005] Immunity. 2006 Feb;24(2):179-89 [16473830] Annu Rev Immunol. 2006;24:99-146 [16551245] Nature. 2006 May 11;441(7090):231-4 [16648837] Nature. 2006 May 11;441(7090):235-8 [16648838] Nat Med. 2006 Jun;12(6):627-35 [16715091] Immunol Rev. 2006 Aug;212:301-13 [16903922] Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2821-6 [17307871] Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6335-40 [17389382] Immunity. 2007 May;26(5):579-91 [17481928] Nat Rev Immunol. 2007 Aug;7(8):622-32 [17641665] Nat Med. 2008 May;14(5):528-35 [18438416] Nat Immunol. 2008 Jun;9(6):632-40 [18438410] Immunity. 2008 Sep 19;29(3):362-71 [18799144] Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14527-32 [18796615] J Neurol Sci. 2008 Nov 15;274(1-2):9-12 [18804221] Nat Med. 1999 Nov;5(11):1298-302 [10545997] Nat Med. 1999 Nov;5(11):1303-7 [10545998] Microbes Infect. 1999 Dec;1(15):1251-3 [10611752] Immunity. 2001 Apr;14(4):407-16 [11336686] J Immunol. 2001 May 15;166(10):6413-22 [11342667] Immunity. 2001 Jun;14(6):715-25 [11420042] J Exp Med. 2001 Aug 20;194(4):439-53 [11514601] Curr Dir Autoimmun. 2002;5:62-91 [11826761] Cytokine. 2002 Apr 7;18(1):43-50 [12090759] Nat Rev Immunol. 2003 Feb;3(2):123-32 [12563296] J Immunol. 2003 May 1;170(9):4612-22 [12707339] J Leukoc Biol. 2004 Jul;76(1):15-24 [14966194] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.0804076 ER - TY - JOUR T1 - Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancer. AN - 67412575; 19117692 AB - To report the long-term outcomes and toxicity of a regimen of infusion paclitaxel delivered concurrently with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck. Between 1995 and 1999, 35 patients with nonmetastatic, Stage III or IV squamous cell carcinoma of the head and neck were treated with three cycles of paclitaxel as a 120-h continuous infusion beginning on Days 1, 21, and 42, concurrent with radiotherapy. The initial 16 patients received 105 mg/m(2)/cycle, and the subsequent 19 patients received 120 mg/m(2)/cycle. External beam radiotherapy was delivered to a dose of 70.2-72 Gy at five fractions weekly. Patients were followed to evaluate the disease outcomes and late toxicity of this regimen. The median follow-up for all patients was 56.5 months. The median survival was 56.5 months, and the median time to local recurrence was not reached. Of the 35 patients, 15 (43%) developed hypothyroidism. Of the 33 patients who underwent percutaneous endoscopic gastrostomy tube placement, 11 were percutaneous endoscopic gastrostomy tube dependent until death or their last follow-up visit. Also, 5 patients (14%) required a tracheostomy until death, and 3 (9%) developed a severe esophageal stricture. All evaluated long-term survivors exhibited salivary hypofunction. Fibrosis in the radiation field occurred in 24 patients (69%). The results of our study have shown that concurrent chemoradiotherapy with a 120-h infusion of paclitaxel provides long-term local control and survival in patients with squamous cell carcinoma of the head and neck. Xerostomia, hypothyroidism, esophageal and pharyngeal complications, and subcutaneous fibrosis were common long-term toxicities; however, the vast majority of toxicities were grade 1 or 2. JF - International journal of radiation oncology, biology, physics AU - Citrin, Deborah AU - Mansueti, John AU - Likhacheva, Anna AU - Sciuto, Linda AU - Albert, Paul S AU - Rudy, Susan F AU - Cooley-Zgela, Theresa AU - Cotrim, Ana AU - Solomon, Beth AU - Colevas, A Dimitrios AU - Russo, Angelo AU - Morris, John C AU - Herscher, Laurie AU - Smith, Sharon AU - Van Waes, Carter AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. citrind@mail.nih.gov Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 1040 EP - 1046 VL - 74 IS - 4 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Combined Modality Therapy -- methods KW - Drug Administration Schedule KW - Fibrosis KW - Humans KW - Aged KW - Radiation Injuries -- pathology KW - Feasibility Studies KW - Skin -- radiation effects KW - Prospective Studies KW - Survival Rate KW - Radiotherapy Dosage KW - Adult KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - Female KW - Male KW - Paclitaxel -- administration & dosage KW - Paclitaxel -- adverse effects KW - Antineoplastic Agents, Phytogenic -- adverse effects KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- mortality KW - Head and Neck Neoplasms -- radiotherapy KW - Head and Neck Neoplasms -- pathology KW - Head and Neck Neoplasms -- mortality KW - Head and Neck Neoplasms -- drug therapy KW - Carcinoma, Squamous Cell -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Antineoplastic Agents, Phytogenic -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67412575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Long-term+outcomes+and+toxicity+of+concurrent+paclitaxel+and+radiotherapy+for+locally+advanced+head-and-neck+cancer.&rft.au=Citrin%2C+Deborah%3BMansueti%2C+John%3BLikhacheva%2C+Anna%3BSciuto%2C+Linda%3BAlbert%2C+Paul+S%3BRudy%2C+Susan+F%3BCooley-Zgela%2C+Theresa%3BCotrim%2C+Ana%3BSolomon%2C+Beth%3BColevas%2C+A+Dimitrios%3BRusso%2C+Angelo%3BMorris%2C+John+C%3BHerscher%2C+Laurie%3BSmith%2C+Sharon%3BVan+Waes%2C+Carter&rft.aulast=Citrin&rft.aufirst=Deborah&rft.date=2009-07-15&rft.volume=74&rft.issue=4&rft.spage=1040&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=1879-355X&rft_id=info:doi/10.1016%2Fj.ijrobp.2008.09.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-23 N1 - Date created - 2009-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1999 Dec 15;91(24):2081-6 [10601378] J Clin Oncol. 2007 Sep 10;25(26):4096-103 [17827459] Int J Radiat Oncol Biol Phys. 1999 May 1;44(2):311-5 [10760424] J Clin Oncol. 2001 Feb 1;19(3):800-11 [11157034] J Clin Oncol. 2001 Mar 1;19(5):1363-73 [11230480] J Clin Oncol. 2001 Apr 1;19(7):1961-9 [11283128] Head Neck. 2001 Aug;23(8):678-82 [11443751] Int J Radiat Oncol Biol Phys. 2001 Nov 1;51(3):599-604 [11597798] Head Neck. 2002 Mar;24(3):228-35 [11891954] Int J Radiat Oncol Biol Phys. 2002 May 1;53(1):23-8 [12007937] Int J Radiat Oncol Biol Phys. 2002 Jul 15;53(4):942-7 [12095561] Head Neck. 2003 Oct;25(10):833-9; discussion 839-40 [12966507] Semin Oncol. 2003 Dec;30(6 Suppl 18):84-8 [14727246] Head Neck. 2004 Apr;26(4):365-72 [15054740] Clin Cancer Res. 2004 Aug 1;10(15):4922-32 [15297392] J Dent Res. 1982 Oct;61(10):1158-62 [6956596] Cancer. 1990 Aug 1;66(3):564-9 [2364368] J Am Dent Assoc. 1991 Mar;122(3):63-9 [2019691] Int J Radiat Oncol Biol Phys. 1995 Mar 30;31(5):1341-6 [7713792] Head Neck. 1997 Oct;19(7):567-75 [9323144] Int J Radiat Oncol Biol Phys. 1999 Mar 15;43(5):1001-8 [10192347] Am J Clin Oncol. 2004 Dec;27(6):595-602 [15577438] Cancer. 2005 Oct 1;104(7):1418-27 [16116597] Curr Opin Oncol. 2007 May;19(3):195-201 [17414636] Radiat Oncol. 2007;2:19 [17540023] Ann Oncol. 2007 Jul;18(7):1224-9 [17675395] Cancer. 2000 Feb 15;88(4):876-83 [10679658] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijrobp.2008.09.053 ER - TY - JOUR T1 - Dietary Fatty Acids and Pancreatic Cancer in the NIH-AARP Diet and Health Study AN - 20235933; 10294993 AB - Background Previous research relating dietary fat, a modifiable risk factor, to pancreatic cancer has been inconclusive.Methods We prospectively analyzed the association between intakes of fat, fat subtypes, and fat food sources and exocrine pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study, a US cohort of 308736 men and 216737 women who completed a 124-item food frequency questionnaire in 1995-1996. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models, with adjustment for energy intake, smoking history, body mass index, and diabetes. Statistical tests were two-sided.Results Over an average follow-up of 6.3 years, 865 men and 472 women were diagnosed with exocrine pancreatic cancer (45.0 and 34.5 cases per 100000 person-years, respectively). After multivariable adjustment and combination of data for men and women, pancreatic cancer risk was directly related to the intakes of total fat (highest vs lowest quintile, 46.8 vs 33.2 cases per 100000 person-years, HR = 1.23, 95% CI = 1.03 to 1.46; Ptrend =.03), saturated fat (51.5 vs 33.1 cases per 100000 person-years, HR = 1.36, 95% CI = 1.14 to 1.62; Ptrend < .001), and monounsaturated fat (46.2 vs 32.9 cases per 100000 person-years, HR=1.22, 95% CI=1.02 to 1.46; Ptrend = .05) but not polyunsaturated fat. The associations were strongest for saturated fat from animal food sources (52.0 vs 32.2 cases per 100000 person-years, HR = 1.43, 95% CI = 1.20 to 1.70; Ptrend < .001); specifically, intakes from red meat and dairy products were both statistically significantly associated with increased pancreatic cancer risk (HR = 1.27 and 1.19, respectively).Conclusion In this large prospective cohort with a wide range of intakes, dietary fat of animal origin was associated with increased pancreatic cancer risk. JF - Journal of the National Cancer Institute AU - Thiebaut, Anne CM AU - Jiao, Li AU - Silverman, Debra T AU - Cross, Amanda J AU - Thompson, Frances E AU - Subar, Amy F AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Stolzenberg-Solomon, Rachael Z Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 1001 EP - 1011 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 101 IS - 14 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Diets KW - Historical account KW - Smoking KW - pancreatic cancer KW - diabetes mellitus KW - body mass KW - Fatty acids KW - Dairy products KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20235933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Dietary+Fatty+Acids+and+Pancreatic+Cancer+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Thiebaut%2C+Anne+CM%3BJiao%2C+Li%3BSilverman%2C+Debra+T%3BCross%2C+Amanda+J%3BThompson%2C+Frances+E%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Thiebaut&rft.aufirst=Anne&rft.date=2009-07-15&rft.volume=101&rft.issue=14&rft.spage=1001&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp168 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Smoking; Historical account; diabetes mellitus; pancreatic cancer; body mass; Dairy products; Fatty acids; Cancer DO - http://dx.doi.org/10.1093/jnci/djp168 ER - TY - JOUR T1 - Underlying Causes of the Black-White Racial Disparity in Breast Cancer Mortality: A Population-Based Analysis AN - 20211140; 10295004 AB - Background In the United States, a black-to-white disparity in age-standardized breast cancer mortality rates emerged in the 1980s and has widened since then.Methods To further explore this racial disparity, black-to-white rate ratios (RRsBW) for mortality, incidence, hazard of breast cancer death, and incidence-based mortality (IBM) were investigated using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program on 244786 women who were diagnosed with breast cancer from January 1990 through December 2003 and followed through December 2004. A counterfactual approach was used to examine the expected IBM RRsBW, assuming equal distributions for estrogen receptor (ER) expression, and/or equal hazard rates of breast cancer death, among black and white women.Results From 1990 through 2004, mortality RRBW was greater than 1.0 and widened over time (age-standardized breast cancer mortality rates fell from 36 to 29 per 100000 for blacks and from 30 to 22 per 100000 for whites). In contrast, incidence RRBW was generally less than 1.0. Absolute hazard rates of breast cancer death declined substantially for ER-positive tumors and modestly for ER-negative tumors but were persistently higher for blacks than whites. Equalizing the distributions of ER expression in blacks and whites decreased the IBM RRBW slightly. Interestingly, the black-to-white disparity in IBM RRBW was essentially eliminated when hazard rates of breast cancer death were matched within each ER category.Conclusions The black-to-white disparity in age-standardized breast cancer mortality was largely driven by the higher hazard rates of breast cancer death among black women, diagnosed with the disease, irrespective of ER expression, and especially in the first few years following diagnosis. Greater emphasis should be placed on identifying the etiology of these excess hazards and developing therapeutic strategies to address them. JF - Journal of the National Cancer Institute AU - Menashe, Idan AU - Anderson, William F AU - Jatoi, Ismail AU - Rosenberg, Philip S Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 993 EP - 1000 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 101 IS - 14 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - USA KW - Etiology KW - Breast cancer KW - tumors KW - Cancer KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20211140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuro-oncology&rft.atitle=A+pilot+study+of+everolimus+and+gefitinib+in+the+treatment+of+recurrent+glioblastoma+%28GBM%29.&rft.au=Kreisl%2C+Teri+N%3BLassman%2C+Andrew+B%3BMischel%2C+Paul+S%3BRosen%2C+Neal%3BScher%2C+Howard+I%3BTeruya-Feldstein%2C+Julie%3BShaffer%2C+David%3BLis%2C+Eric%3BAbrey%2C+Lauren+E&rft.aulast=Kreisl&rft.aufirst=Teri&rft.date=2009-03-01&rft.volume=92&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuro-oncology&rft.issn=0167594X&rft_id=info:doi/10.1007%2Fs11060-008-9741-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Etiology; Breast cancer; tumors; Cancer; estrogens; USA DO - http://dx.doi.org/10.1093/jnci/djp176 ER - TY - JOUR T1 - Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells. AN - 67568570; 19594950 AB - Reovirus type 3 Dearing strain (ReoT3D) has an inherent propensity to preferentially infect and destroy cancer cells. The oncolytic activity of ReoT3D as a single agent has been demonstrated in vitro and in vivo against various cancers, including colon, pancreatic, ovarian and breast cancers. Its human safety and potential efficacy are currently being investigated in early clinical trials. In this study, we investigated the in vitro combination effects of ReoT3D and chemotherapeutic agents against human non-small cell lung cancer (NSCLC). ReoT3D alone exerted significant cytolytic activity in 7 of 9 NSCLC cell lines examined, with the 50% effective dose, defined as the initial virus dose to achieve 50% cell killing after 48 hours of infection, ranging from 1.46 +/- 0.12 approximately 2.68 +/- 0.25 (mean +/- SD) log10 pfu/cell. Chou-Talalay analysis of the combination of ReoT3D with cisplatin, gemcitabine, or vinblastine demonstrated strong synergistic effects on cell killing, but only in cell lines that were sensitive to these compounds. In contrast, the combination of ReoT3D and paclitaxel was invariably synergistic in all cell lines tested, regardless of their levels of sensitivity to either agent. Treatment of NSCLC cell lines with the ReoT3D-paclitaxel combination resulted in increased poly (ADP-ribose) polymerase cleavage and caspase activity compared to single therapy, indicating enhanced apoptosis induction in dually treated NSCLC cells. NSCLC cells treated with the ReoT3D-paclitaxel combination showed increased proportions of mitotic and apoptotic cells, and a more pronounced level of caspase-3 activation was demonstrated in mitotically arrested cells. These data suggest that the oncolytic activity of ReoT3D can be potentiated by taxanes and other chemotherapeutic agents, and that the ReoT3D-taxane combination most effectively achieves synergy through accelerated apoptosis triggered by prolonged mitotic arrest. JF - Molecular cancer AU - Sei, Shizuko AU - Mussio, Jodie K AU - Yang, Quan-en AU - Nagashima, Kunio AU - Parchment, Ralph E AU - Coffey, Matthew C AU - Shoemaker, Robert H AU - Tomaszewski, Joseph E AD - Laboratory of Human Toxicology and Pharmacology, SAIC-Frederick, Inc, NCI-Frederick, Frederick, Maryland, USA. seis@mail.nih.gov Y1 - 2009/07/14/ PY - 2009 DA - 2009 Jul 14 SP - 47 VL - 8 KW - Deoxycytidine KW - 0W860991D6 KW - Vinblastine KW - 5V9KLZ54CY KW - gemcitabine KW - B76N6SBZ8R KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Caspases KW - EC 3.4.22.- KW - ras Proteins KW - EC 3.6.5.2 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Combined Modality Therapy KW - Deoxycytidine -- analogs & derivatives KW - Humans KW - Cell Line, Tumor KW - Virion -- physiology KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Caspases -- metabolism KW - Cell Survival -- drug effects KW - Vinblastine -- administration & dosage KW - Enzyme Activation -- drug effects KW - Deoxycytidine -- administration & dosage KW - ras Proteins -- metabolism KW - Drug Synergism KW - Cell Cycle -- drug effects KW - Oncolytic Virotherapy -- methods KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- virology KW - Mammalian orthoreovirus 3 -- physiology KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- therapy KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- virology KW - Carcinoma, Non-Small-Cell Lung -- therapy KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67568570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer&rft.atitle=Synergistic+antitumor+activity+of+oncolytic+reovirus+and+chemotherapeutic+agents+in+non-small+cell+lung+cancer+cells.&rft.au=Sei%2C+Shizuko%3BMussio%2C+Jodie+K%3BYang%2C+Quan-en%3BNagashima%2C+Kunio%3BParchment%2C+Ralph+E%3BCoffey%2C+Matthew+C%3BShoemaker%2C+Robert+H%3BTomaszewski%2C+Joseph+E&rft.aulast=Sei&rft.aufirst=Shizuko&rft.date=2009-07-14&rft.volume=8&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer&rft.issn=1476-4598&rft_id=info:doi/10.1186%2F1476-4598-8-47 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-20 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 1998 Jun 15;17(12):3351-62 [9628872] Nature. 1998 Mar 19;392(6673):300-3 [9521327] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Cancer Cell. 2005 Jul;8(1):7-12 [16023594] Gene Ther. 2005 Aug;12(15):1198-205 [15800658] J Natl Cancer Inst. 2005 Oct 5;97(19):1407-27 [16204691] J Gastrointest Surg. 2005 Nov;9(8):1068-77; discussion 1077-9 [16269377] Nat Rev Cancer. 2005 Dec;5(12):965-76 [16294217] Nat Rev Cancer. 2006 Oct;6(10):813-23 [16990858] Cancer Gene Ther. 2006 Dec;13(12):1105-14 [16841078] Mol Cancer Ther. 2006 Nov;5(11):2606-12 [17088437] Mol Cancer Ther. 2006 Dec;5(12):2963-9 [17172401] Nat Rev Mol Cell Biol. 2007 May;8(5):379-93 [17426725] Mol Ther. 2007 Aug;15(8):1512-21 [17519890] Clin Cancer Res. 2008 Feb 1;14(3):912-23 [18245555] Cancer Gene Ther. 2008 May;15(5):284-92 [18259212] Cochrane Database Syst Rev. 2000;(2):CD002139 [10796867] J Virol. 2000 Oct;74(20):9562-70 [11000227] Cancer Res. 2001 Jan 15;61(2):517-25 [11212244] Cell. 2001 Feb 9;104(3):441-51 [11239401] Oncogene. 2001 Jan 11;20(2):147-55 [11313944] J Natl Cancer Inst. 2001 Jun 20;93(12):903-12 [11416111] Oncogene. 2001 Oct 18;20(47):6910-9 [11687970] Cancer Res. 2002 Mar 15;62(6):1696-701 [11912142] Hum Gene Ther. 2002 Mar 20;13(5):641-52 [11916487] J Virol. 2002 May;76(9):4483-96 [11932414] J Virol. 2002 Aug;76(15):7430-43 [12097555] Blood. 2002 Dec 1;100(12):4146-53 [12393565] Clin Cancer Res. 2003 Mar;9(3):1218-23 [12631628] Cancer Res. 2003 Apr 1;63(7):1508-14 [12670897] Virus Res. 2003 May;93(1):1-12 [12727337] Apoptosis. 2003 Mar;8(2):141-50 [12766474] Mol Biol Cell. 2003 May;14(5):2071-87 [12802076] Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11099-104 [15263068] Nat Rev Cancer. 2004 Aug;4(8):592-603 [15286739] Mol Pharmacol. 1974 Mar;10(2):235-47 [4212316] J Natl Cancer Inst. 1976 Feb;56(2):245-63 [1255758] J Virol. 1978 Nov;28(2):444-9 [214572] Adv Enzyme Regul. 1984;22:27-55 [6382953] J Virol. 1988 Dec;62(12):4594-604 [2460637] J Natl Cancer Inst. 1989 Apr 19;81(8):577-86 [2495366] Cancer Res. 1995 May 15;55(10):2122-8 [7743512] Hum Gene Ther. 1999 Dec 10;10(18):3013-29 [10609661] Nature. 1995 Oct 5;377(6548):446-8 [7566124] J Virol. 1996 Jan;70(1):612-6 [8523580] Int J Cancer. 1996 Jan 17;65(2):230-7 [8567122] J Virol. 1997 Mar;71(3):1834-41 [9032313] Science. 1998 Nov 13;282(5392):1332-4 [9812900] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1476-4598-8-47 ER - TY - JOUR T1 - Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms. AN - 67501649; 19564615 AB - A variety of mechanisms maintain the integrity of the genome in the face of cell stress. Cancer cell response to chemotherapeutic and radiation-induced DNA damage is mediated by multiple defense mechanisms including polo-like kinase 1 (Plk-1), protein kinase B (Akt-1), and/or p53 pathways leading to either apoptosis or cell cycle arrest. Subsequently, a subpopulation of arrested viable cancer cells may remain and recur despite aggressive and repetitive therapy. Here, we show that modulation (activation of Akt-1 and Plk-1 and repression of p53) of these pathways simultaneously results in paradoxical enhancement of the effectiveness of cytotoxic chemotherapy. We demonstrate that a small molecule inhibitor, LB-1.2, of protein phosphatase 2A (PP2A) activates Plk-1 and Akt-1 and decreases p53 abundance in tumor cells. Combined with temozolomide (TMZ; a DNA-methylating chemotherapeutic drug), LB-1.2 causes complete regression of glioblastoma multiforme (GBM) xenografts without recurrence in 50% of animals (up to 28 weeks) and complete inhibition of growth of neuroblastoma (NB) xenografts. Treatment with either drug alone results in only short-term inhibition/regression with all xenografts resuming rapid growth. Combined with another widely used anticancer drug, Doxorubicin (DOX, a DNA intercalating agent), LB-1.2 also causes marked GBM xenograft regression, whereas DOX alone only slows growth. Inhibition of PP2A by LB-1.2 blocks cell-cycle arrest and increases progression of cell cycle in the presence of TMZ or DOX. Pharmacologic inhibition of PP2A may be a general method for enhancing the effectiveness of cancer treatments that damage DNA or disrupt components of cell replication. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Lu, Jie AU - Kovach, John S AU - Johnson, Francis AU - Chiang, Jeffrey AU - Hodes, Richard AU - Lonser, Russell AU - Zhuang, Zhengping AD - Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, 9000 Rockvillle Pike, Bethesda, MD 20892, USA. Y1 - 2009/07/14/ PY - 2009 DA - 2009 Jul 14 SP - 11697 EP - 11702 VL - 106 IS - 28 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Cell Cycle Proteins KW - Enzyme Inhibitors KW - Proto-Oncogene Proteins KW - Dacarbazine KW - 7GR28W0FJI KW - Akt1 protein, mouse KW - EC 2.7.11.1 KW - Protein-Serine-Threonine Kinases KW - Proto-Oncogene Proteins c-akt KW - polo-like kinase 1 KW - Protein Phosphatase 2 KW - EC 3.1.3.16 KW - temozolomide KW - YF1K15M17Y KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Animals KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - Protein-Serine-Threonine Kinases -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - Mice KW - Cell Cycle Proteins -- metabolism KW - Dacarbazine -- therapeutic use KW - Blotting, Western KW - Dacarbazine -- analogs & derivatives KW - Flow Cytometry KW - Mice, SCID KW - Fluorescent Antibody Technique KW - Enzyme Inhibitors -- therapeutic use KW - Neuroblastoma -- drug therapy KW - Gene Expression Regulation, Enzymologic -- drug effects KW - DNA Damage KW - Enzyme Inhibitors -- pharmacology KW - Protein Phosphatase 2 -- antagonists & inhibitors KW - Glioblastoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67501649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Inhibition+of+serine%2Fthreonine+phosphatase+PP2A+enhances+cancer+chemotherapy+by+blocking+DNA+damage+induced+defense+mechanisms.&rft.au=Lu%2C+Jie%3BKovach%2C+John+S%3BJohnson%2C+Francis%3BChiang%2C+Jeffrey%3BHodes%2C+Richard%3BLonser%2C+Russell%3BZhuang%2C+Zhengping&rft.aulast=Lu&rft.aufirst=Jie&rft.date=2009-07-14&rft.volume=106&rft.issue=28&rft.spage=11697&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0905930106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-09 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Cancer. 2008 Jul;8(7):512-22 [18574463] J Biol Chem. 2008 May 16;283(20):13707-13 [18356162] PLoS One. 2008;3(7):e2639 [18612384] Cell Death Differ. 2008 Aug;15(8):1211-20 [18274553] Oncogene. 2008 Sep 18;27(41):5511-26 [18794885] J Clin Oncol. 2008 Dec 1;26(34):5497-9 [18955441] Nat Rev Drug Discov. 2008 Dec;7(12):979-87 [19043449] Cancer Gene Ther. 2009 Jan;16(1):1-12 [18802452] J Clin Oncol. 2009 Feb 1;27(4):579-84 [19075262] Oncogene. 2008 Jun 26;27(28):3935-43 [18297112] Nature. 2000 Nov 16;408(6810):307-10 [11099028] Mol Cell Biol. 2002 Sep;22(17):6209-21 [12167714] Int J Biochem Cell Biol. 2004 Mar;36(3):379-85 [14687915] Bioorg Med Chem Lett. 2004 Apr 19;14(8):1969-73 [15050639] Oncogene. 2004 Apr 12;23(16):2825-37 [15077146] Trends Biochem Sci. 2004 May;29(5):233-42 [15130559] Pharmacol Rev. 2004 Jun;56(2):185-229 [15169927] Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15364-9 [15489264] Cancer Res. 2005 Jun 1;65(11):4861-9 [15930307] Mol Cell Biol. 2006 Mar;26(6):2093-108 [16507989] Nat Rev Cancer. 2006 Apr;6(4):321-30 [16557283] J Clin Oncol. 2006 Nov 20;24(33):5259-64 [17114659] Mol Cancer Ther. 2006 Nov;5(11):2727-36 [17121919] Cell Cycle. 2007 Feb 15;6(4):467-70 [17312396] Mol Biol Cell. 2007 Jul;18(7):2525-32 [17475776] Neuro Oncol. 2007 Oct;9(4):404-11 [17704360] Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19011-6 [18006659] Trends Mol Med. 2008 Apr;14(4):152-60 [18329957] Erratum In: Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14734 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0905930106 ER - TY - JOUR T1 - Coronary artery calcification screening: estimated radiation dose and cancer risk. AN - 67476564; 19597067 AB - Multidetector computed tomography has been proposed as a tool for routine screening for coronary artery calcification in asymptomatic individuals. As proposed, such screening could involve tens of millions of individuals, but detailed estimates of radiation doses and potential risk of radiation-induced cancer are not currently available. We estimated organ-specific radiation doses and associated cancer risks from coronary artery calcification screening with multidetector computed tomography according to patient age, frequency of screening, and scan protocol. Radiation doses delivered to adult patients were calculated from a range of available protocols using Monte Carlo radiation transport. Radiation risk models, derived using data from Japanese atomic bomb survivors and medically exposed cohorts, were used to estimate the excess lifetime risk of radiation-induced cancer. The radiation dose from a single coronary artery calcification computed tomographic scan varied more than 10-fold (effective dose range, 0.8-10.5 mSv) depending on the protocol. In general, higher radiation doses were associated with higher x-ray tube current, higher tube potential, spiral scanning with low pitch, and retrospective gating. The wide dose variation also resulted in wide variation in estimated radiation-induced cancer risk. Assuming screening every 5 years from the age of 45 to 75 years for men and 55 to 75 years for women, the estimated excess lifetime cancer risk using the median dose of 2.3 mSv was 42 cases per 100 000 men (range, 14-200 cases) and 62 cases per 100 000 women (range, 21-300 cases). These radiation risk estimates can be compared with potential benefits from screening, when such estimates are available. Doses and therefore risks can be minimized by the use of optimized protocols. JF - Archives of internal medicine AU - Kim, Kwang Pyo AU - Einstein, Andrew J AU - Berrington de González, Amy AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/07/13/ PY - 2009 DA - 2009 Jul 13 SP - 1188 EP - 1194 VL - 169 IS - 13 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Incidence KW - United States -- epidemiology KW - Tomography, X-Ray Computed -- methods KW - Radiation Dosage KW - Neoplasms, Radiation-Induced -- etiology KW - Tomography, X-Ray Computed -- adverse effects KW - Neoplasms, Radiation-Induced -- epidemiology KW - Calcinosis -- diagnostic imaging KW - Risk Assessment -- methods KW - Coronary Artery Disease -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67476564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Coronary+artery+calcification+screening%3A+estimated+radiation+dose+and+cancer+risk.&rft.au=Kim%2C+Kwang+Pyo%3BEinstein%2C+Andrew+J%3BBerrington+de+Gonz%C3%A1lez%2C+Amy&rft.aulast=Kim&rft.aufirst=Kwang&rft.date=2009-07-13&rft.volume=169&rft.issue=13&rft.spage=1188&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=1538-3679&rft_id=info:doi/10.1001%2Farchinternmed.2009.162 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-06 N1 - Date created - 2009-07-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiat Res. 2002 Aug;158(2):220-35 [12105993] Health Technol Assess. 2006 Oct;10(39):iii-iv, ix-x, 1-41 [17018228] Circulation. 2002 Dec 17;106(25):3143-421 [12485966] Radiology. 2003 Jan;226(1):145-52 [12511683] Circulation. 2003 Feb 18;107(6):917-22 [12591765] Herz. 2003 Feb;28(1):1-6 [12616315] Acad Radiol. 2003 Apr;10(4):386-401 [12678178] Rofo. 2003 Aug;175(8):1051-5 [12886472] Eur Radiol. 2003 Aug;13(8):1979-91 [12687286] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13761-6 [14610281] Rofo. 2002 Dec;174(12):1500-5 [12471520] Am J Cardiol. 2007 Apr 1;99(7):1013-5 [17398203] Radiology. 2007 May;243(2):527-38 [17456875] JAMA. 2007 Jul 18;298(3):317-23 [17635892] Radiat Res. 2007 Jul;168(1):1-64 [17722996] J Am Soc Echocardiogr. 2007 Sep;20(9):1021-41 [17765820] Am J Respir Crit Care Med. 2007 Nov 15;176(10):970-3 [17717201] Radiology. 2008 Jul;248(1):160-8 [18483231] Radiology. 2008 Jul;248(1):254-63 [18566177] Arch Intern Med. 2008 Jun 23;168(12):1333-9 [18574091] Med Phys. 2008 Jun;35(6):2366-82 [18649470] J Nucl Cardiol. 2006 Nov;13(6):e80-90 [17174798] Lancet. 2004 Jan 31;363(9406):345-51 [15070562] Environ Health Perspect. 1981 Dec;42:15-21 [7333252] Radiat Res. 1995 Mar;141(3):259-77 [7871153] Radiology. 2005 Jan;234(1):35-43 [15618373] Circulation. 2005 Oct 11;112(15):2318-23 [16203914] J Am Coll Cardiol. 2006 May 2;47(9):1840-5 [16682310] Am J Cardiol. 2006 Jul 17;98(2A):2H-15H [16843744] Comment In: Arch Intern Med. 2009 Jul 13;169(13):1185-7 [19597066] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archinternmed.2009.162 ER - TY - CPAPER T1 - T Cell Factor-1 Initiates T Helper 2 Fate by Inducing Gata-3 and Repressing IFNgamma T2 - Molecular Mechanisms of Lymphocyte Differentiation: From Stem Cells to Effector Cells AN - 40298145; 5240216 JF - Molecular Mechanisms of Lymphocyte Differentiation: From Stem Cells to Effector Cells AU - Sen, Jyoti Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - G-Interferon KW - Lymphocytes T KW - GATA-3 protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40298145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Molecular+Mechanisms+of+Lymphocyte+Differentiation%3A+From+Stem+Cells+to+Effector+Cells&rft.atitle=T+Cell+Factor-1+Initiates+T+Helper+2+Fate+by+Inducing+Gata-3+and+Repressing+IFNgamma&rft.au=Sen%2C+Jyoti&rft.aulast=Sen&rft.aufirst=Jyoti&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Molecular+Mechanisms+of+Lymphocyte+Differentiation%3A+From+Stem+Cells+to+Effector+Cells&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11655.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic and Genetic Analyses to Uncover the Achilles Heel of Lymphoid Malignancies T2 - Molecular Mechanisms of Lymphocyte Differentiation: From Stem Cells to Effector Cells AN - 40297615; 5240231 JF - Molecular Mechanisms of Lymphocyte Differentiation: From Stem Cells to Effector Cells AU - Staudt, Louis Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Malignancy KW - Genomics KW - Genetic analysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40297615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Noninvasive+monitoring+of+a+murine+model+of+metastatic+pheochromocytoma%3A+A+comparison+of+contrast-enhanced+microCT+and+nonenhanced+MRI&rft.au=Martiniova%2C+Lucia%3BKotys%2C+Melanie+S%3BThomasson%2C+David%3BSchimel%2C+Daniel%3BLai%2C+Edwin+W%3BBernardo%2C+Marcelino%3BMerino%2C+Maria+J%3BPowers%2C+James+F%3BRuzicka%2C+Jan%3BKvetnansky%2C+Richard%3BChoyke%2C+Peter+L%3BPacak%2C+Karel&rft.aulast=Martiniova&rft.aufirst=Lucia&rft.date=2009-03-01&rft.volume=29&rft.issue=3&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.21654 L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11655.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcriptional Control of CD4 Lineage Differentiation in the Thymus T2 - Molecular Mechanisms of Lymphocyte Differentiation: From Stem Cells to Effector Cells AN - 40297014; 5240193 JF - Molecular Mechanisms of Lymphocyte Differentiation: From Stem Cells to Effector Cells AU - Bosselut, Remy Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Thymus KW - Differentiation KW - Transcription KW - CD4 antigen KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40297014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Molecular+Mechanisms+of+Lymphocyte+Differentiation%3A+From+Stem+Cells+to+Effector+Cells&rft.atitle=Transcriptional+Control+of+CD4+Lineage+Differentiation+in+the+Thymus&rft.au=Bosselut%2C+Remy&rft.aulast=Bosselut&rft.aufirst=Remy&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Molecular+Mechanisms+of+Lymphocyte+Differentiation%3A+From+Stem+Cells+to+Effector+Cells&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11655.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of instinct, affect and action in the amygdala and orbital frontal cortex T2 - 2009 Gordon Research Conference on Amygdala in Health and Disease AN - 40200694; 5185036 JF - 2009 Gordon Research Conference on Amygdala in Health and Disease AU - Murray, Elisabeth Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Instinct KW - Amygdala KW - Cortex (frontal) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40200694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Amygdala+in+Health+and+Disease&rft.atitle=Interaction+of+instinct%2C+affect+and+action+in+the+amygdala+and+orbital+frontal+cortex&rft.au=Murray%2C+Elisabeth&rft.aulast=Murray&rft.aufirst=Elisabeth&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Amygdala+in+Health+and+Disease&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=amygdala LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Watching proteins function in real time via time -resolved X-rayrayray diffraction and solution scattering T2 - 7th European Biophysics Congress AN - 40287418; 5237329 JF - 7th European Biophysics Congress AU - Anfinrud, Philip Y1 - 2009/07/11/ PY - 2009 DA - 2009 Jul 11 KW - Diffraction KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40287418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Practicing+what+they+preach%3A+health+behaviors+of+those+who+provide+health+advice+to+extensive+social+networks&rft.au=Colon-Ramos%2C+Uriyoan%3BAtienza%2C+Audie%3BWeber%2C+Deanne%3BTaylor%2C+Melissa%3BUy%2C+Christina%3BYaroch%2C+Amy&rft.aulast=Colon-Ramos&rft.aufirst=Uriyoan&rft.date=2009-03-01&rft.volume=14&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730802659111 L2 - http://www.ebsa2009.org/wp-content/uploads/2009/07/programma-opt_sito. pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Telomeres and Telomerase in Stem Cell Biology: Generation of Long-Lived Mice T2 - 7th Annual Meeting of the International Society for Stem Cell Research AN - 40241219; 5215244 JF - 7th Annual Meeting of the International Society for Stem Cell Research AU - Blasco, Maria Y1 - 2009/07/08/ PY - 2009 DA - 2009 Jul 08 KW - Stem cells KW - Mice KW - Telomerase KW - Telomeres KW - Cytology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40241219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.atitle=Role+of+Telomeres+and+Telomerase+in+Stem+Cell+Biology%3A+Generation+of+Long-Lived+Mice&rft.au=Blasco%2C+Maria&rft.aulast=Blasco&rft.aufirst=Maria&rft.date=2009-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Annual+Meeting+of+the+International+Society+for+Stem+Cell+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.isscr.org/ScriptContent/ISSCR09-final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microbial Translocation and Disease Progression in HIV and Other Primate Lentiviral Infections T2 - 10th Biennial Congress of the Anaerobe Society of the Americas (Anaerobe 2010) AN - 866038492; 5973942 JF - 10th Biennial Congress of the Anaerobe Society of the Americas (Anaerobe 2010) AU - Brenchley, Jason Y1 - 2009/07/07/ PY - 2009 DA - 2009 Jul 07 KW - Human immunodeficiency virus KW - translocation KW - infection KW - Primates KW - Infection KW - Translocation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866038492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Biennial+Congress+of+the+Anaerobe+Society+of+the+Americas+%28Anaerobe+2010%29&rft.atitle=Microbial+Translocation+and+Disease+Progression+in+HIV+and+Other+Primate+Lentiviral+Infections&rft.au=Brenchley%2C+Jason&rft.aulast=Brenchley&rft.aufirst=Jason&rft.date=2009-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Biennial+Congress+of+the+Anaerobe+Society+of+the+Americas+%28Anaerobe+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.anaerobe.org/2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - JOUR T1 - Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial AN - 20936512; 10986146 AB - Background:Epidemiological evidence on meat intake and breast cancer is inconsistent, with little research on potentially carcinogenic meat-related exposures. We investigated meat subtypes, cooking practices, meat mutagens, iron, and subsequent breast cancer risk. Methods:Among 52158 women (aged 55-74 years) in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, who completed a food frequency questionnaire, 1205 invasive breast cancer cases were identified. We estimated meat mutagen and haem iron intake with databases accounting for cooking practices. Using Cox proportional hazards regression, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) within quintiles of intake. Results:Comparing the fifth to the first quintile, red meat (HR=1.23; 95% CI=1.00-1.51, P trend=0.22), the heterocyclic amine (HCA), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), (HR=1.26; 95% CI=1.03-1.55; P trend=0.12), and dietary iron (HR=1.25; 95% CI=1.02-1.52; P trend=0.03) were positively associated with breast cancer. We observed elevated, though not statistically significant, risks with processed meat, the HCA 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), mutagenic activity, iron from meat, and haem iron from meat. Conclusion:In this prospective study, red meat, MeIQx, and dietary iron elevated the risk of invasive breast cancer, but there was no linear trend in the association except for dietary iron.British Journal of Cancer (2009) 101, 178-184; doi:10.1038/sj.bjc.6605118 www.bjcancer.com Published online online 9 June 2009 JF - British Journal of Cancer AU - Ferrucci, L M AU - Cross, A J AU - Graubard, B I AU - Brinton, L A AU - McCarty, C A AU - Ziegler, R G AU - Ma, X AU - Mayne, S T AU - Sinha, R AD - [1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD 20852, USA [2] Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA Y1 - 2009/07/07/ PY - 2009 DA - 2009 Jul 07 SP - 178 EP - 184 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 101 IS - 1 SN - 0007-0920, 0007-0920 KW - Toxicology Abstracts; Risk Abstracts KW - Heterocyclic amines KW - Mutagens KW - Invasiveness KW - Food KW - Statistical analysis KW - Cooking KW - cooking KW - Diets KW - Inventories KW - Ovarian cancer KW - ovarian carcinoma KW - Amines KW - Meat KW - Databases KW - Lung KW - Breast cancer KW - Prostate KW - Iron KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20936512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Intake+of+meat%2C+meat+mutagens%2C+and+iron+and+the+risk+of+breast+cancer+in+the+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial&rft.au=Ferrucci%2C+L+M%3BCross%2C+A+J%3BGraubard%2C+B+I%3BBrinton%2C+L+A%3BMcCarty%2C+C+A%3BZiegler%2C+R+G%3BMa%2C+X%3BMayne%2C+S+T%3BSinha%2C+R&rft.aulast=Ferrucci&rft.aufirst=L&rft.date=2009-07-07&rft.volume=101&rft.issue=1&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605118 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mutagens; Ovarian cancer; Inventories; Heterocyclic amines; Invasiveness; Food; Statistical analysis; Meat; Databases; Cooking; Breast cancer; Iron; Prostate; Diets; Lung; ovarian carcinoma; cooking; Amines DO - http://dx.doi.org/10.1038/sj.bjc.6605118 ER - TY - CPAPER T1 - The Population Dynamics of Coupled Neurons in a Finite-size Network T2 - 2009 Annual Meeting of the Society for Industrial and Applied Mathematics AN - 40247135; 5214649 JF - 2009 Annual Meeting of the Society for Industrial and Applied Mathematics AU - Chow, Carson Y1 - 2009/07/06/ PY - 2009 DA - 2009 Jul 06 KW - Population dynamics KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40247135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Society+for+Industrial+and+Applied+Mathematics&rft.atitle=The+Population+Dynamics+of+Coupled+Neurons+in+a+Finite-size+Network&rft.au=Chow%2C+Carson&rft.aulast=Chow&rft.aufirst=Carson&rft.date=2009-07-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Society+for+Industrial+and+Applied+Mathematics&rft.issn=&rft_id=info:doi/ L2 - http://meetings.siam.org/program.cfm?CONFCODE=AN09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Place of sarcopenia in the frailty syndrome T2 - 19th IAGG World Congress of Gerontology and Geriatrics AN - 41969594; 5308894 JF - 19th IAGG World Congress of Gerontology and Geriatrics AU - Ferrucci, Luigi Y1 - 2009/07/05/ PY - 2009 DA - 2009 Jul 05 KW - Sarcopenia KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41969594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+IAGG+World+Congress+of+Gerontology+and+Geriatrics&rft.atitle=Place+of+sarcopenia+in+the+frailty+syndrome&rft.au=Ferrucci%2C+Luigi&rft.aulast=Ferrucci&rft.aufirst=Luigi&rft.date=2009-07-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+IAGG+World+Congress+of+Gerontology+and+Geriatrics&rft.issn=&rft_id=info:doi/ L2 - http://www.gerontologyparis2009.com/site/IAGG_09_Finalprogramme.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - "Role of Parkin in mitochondrial quality control" T2 - Mitochondrial assembly and dynamics in health and disease AN - 40296553; 5240126 JF - Mitochondrial assembly and dynamics in health and disease AU - Youle, Richard Y1 - 2009/07/05/ PY - 2009 DA - 2009 Jul 05 KW - Quality control KW - Mitochondria KW - Parkin protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40296553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Mitochondrial+assembly+and+dynamics+in+health+and+disease&rft.atitle=%22Role+of+Parkin+in+mitochondrial+quality+control%22&rft.au=Youle%2C+Richard&rft.aulast=Youle&rft.aufirst=Richard&rft.date=2009-07-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Mitochondrial+assembly+and+dynamics+in+health+and+disease&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11654.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor suppressor p53 binding sites in human genome reside in Alu repeats T2 - Mobile Elements in Mammalian Genomes AN - 40295469; 5240160 JF - Mobile Elements in Mammalian Genomes AU - Zhurkin, Victor Y1 - 2009/07/05/ PY - 2009 DA - 2009 Jul 05 KW - Tumors KW - Genomes KW - P53 protein KW - Tumor suppressor genes KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40295469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Mobile+Elements+in+Mammalian+Genomes&rft.atitle=Tumor+suppressor+p53+binding+sites+in+human+genome+reside+in+Alu+repeats&rft.au=Zhurkin%2C+Victor&rft.aulast=Zhurkin&rft.aufirst=Victor&rft.date=2009-07-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Mobile+Elements+in+Mammalian+Genomes&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11704.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - "Cellular damages induced by osmotic stress" T2 - 2009 Gordon Research Conference on Cellular Osmoregulation & Mechanotransduction AN - 40294734; 5240900 JF - 2009 Gordon Research Conference on Cellular Osmoregulation & Mechanotransduction AU - Dmitrieva, Natalia Y1 - 2009/07/05/ PY - 2009 DA - 2009 Jul 05 KW - Stress KW - Osmotic stress KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40294734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Cellular+Osmoregulation+%26+Mechanotransduction&rft.atitle=%22Cellular+damages+induced+by+osmotic+stress%22&rft.au=Dmitrieva%2C+Natalia&rft.aulast=Dmitrieva&rft.aufirst=Natalia&rft.date=2009-07-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Cellular+Osmoregulation+%26+Mechanotransduction&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=cellosmo LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kinetic and super-resolution analysis of Golgi structure and function T2 - 2009 Gordon Research Conference on Molecular Membrane Biology AN - 40208664; 5184585 JF - 2009 Gordon Research Conference on Molecular Membrane Biology AU - Lippincott-Schwartz, Jennifer Y1 - 2009/07/05/ PY - 2009 DA - 2009 Jul 05 KW - Kinetics KW - Structure-function relationships KW - Golgi apparatus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40208664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Molecular+Membrane+Biology&rft.atitle=Kinetic+and+super-resolution+analysis+of+Golgi+structure+and+function&rft.au=Lippincott-Schwartz%2C+Jennifer&rft.aulast=Lippincott-Schwartz&rft.aufirst=Jennifer&rft.date=2009-07-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Molecular+Membrane+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=molecmemb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ceramide transfer protein: CERT'nly different tales T2 - 2009 Gordon Research Conference on Molecular Membrane Biology AN - 40195240; 5184577 JF - 2009 Gordon Research Conference on Molecular Membrane Biology AU - Acharya, Jairaj Y1 - 2009/07/05/ PY - 2009 DA - 2009 Jul 05 KW - Ceramide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40195240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Molecular+Membrane+Biology&rft.atitle=Ceramide+transfer+protein%3A+CERT%27nly+different+tales&rft.au=Acharya%2C+Jairaj&rft.aulast=Acharya&rft.aufirst=Jairaj&rft.date=2009-07-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Molecular+Membrane+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=molecmemb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vesicle formation and scission by the ESCRT-III complex T2 - 2009 Gordon Research Conference on Molecular Membrane Biology AN - 40194825; 5184601 JF - 2009 Gordon Research Conference on Molecular Membrane Biology AU - Wollert, Thomas Y1 - 2009/07/05/ PY - 2009 DA - 2009 Jul 05 KW - Vesicles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40194825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Molecular+Membrane+Biology&rft.atitle=Vesicle+formation+and+scission+by+the+ESCRT-III+complex&rft.au=Wollert%2C+Thomas&rft.aulast=Wollert&rft.aufirst=Thomas&rft.date=2009-07-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Molecular+Membrane+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=molecmemb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tail-anchored membrane protein insertion into the ER T2 - 2009 Gordon Research Conference on Molecular Membrane Biology AN - 40193170; 5184559 JF - 2009 Gordon Research Conference on Molecular Membrane Biology AU - Hegde, Ramanujan Y1 - 2009/07/05/ PY - 2009 DA - 2009 Jul 05 KW - Membrane proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40193170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Molecular+Membrane+Biology&rft.atitle=Tail-anchored+membrane+protein+insertion+into+the+ER&rft.au=Hegde%2C+Ramanujan&rft.aulast=Hegde&rft.aufirst=Ramanujan&rft.date=2009-07-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Molecular+Membrane+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=molecmemb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Asymmetric cell division through epigenetic differentiation of sister chromatids and their selective segregation in mitosis T2 - 34th Congress of the Federation of European Biochemical Societies AN - 40293282; 5236389 JF - 34th Congress of the Federation of European Biochemical Societies AU - Klar, A Y1 - 2009/07/04/ PY - 2009 DA - 2009 Jul 04 KW - Mitosis KW - Cell division KW - Differentiation KW - Epigenetics KW - Sister chromatids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40293282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=34th+Congress+of+the+Federation+of+European+Biochemical+Societies&rft.atitle=Asymmetric+cell+division+through+epigenetic+differentiation+of+sister+chromatids+and+their+selective+segregation+in+mitosis&rft.au=Klar%2C+A&rft.aulast=Klar&rft.aufirst=A&rft.date=2009-07-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=34th+Congress+of+the+Federation+of+European+Biochemical+Societies&rft.issn=&rft_id=info:doi/ L2 - http://www.febs2009.org/images/stories/programme/FEBS2009-Programme.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. AN - 67429814; 19419957 AB - FANCJ mutations are genetically linked to the Fanconi anemia complementation group J and predispose individuals to breast cancer. Understanding the role of FANCJ in DNA metabolism and how FANCJ dysfunction leads to tumorigenesis requires mechanistic studies of FANCJ helicase and its protein partners. In this work, we have examined the ability of FANCJ to unwind DNA molecules with specific base damage that can be mutagenic or lethal. FANCJ was inhibited by a single thymine glycol, but not 8-oxoguanine, in either the translocating or nontranslocating strands of the helicase substrate. In contrast, the human RecQ helicases (BLM, RECQ1, and WRN) display strand-specific inhibition of unwinding by the thymine glycol damage, whereas other DNA helicases (DinG, DnaB, and UvrD) are not significantly inhibited by thymine glycol in either strand. In the presence of replication protein A (RPA), but not Escherichia coli single-stranded DNA-binding protein, FANCJ efficiently unwound the DNA substrate harboring the thymine glycol damage in the nontranslocating strand; however, inhibition of FANCJ helicase activity by the translocating strand thymine glycol was not relieved. Strand-specific stimulation of human RECQ1 helicase activity was also observed, and RPA bound with high affinity to single-stranded DNA containing a single thymine glycol. Based on the biochemical studies, we propose a model for the specific functional interaction between RPA and FANCJ on the thymine glycol substrates. These studies are relevant to the roles of RPA, FANCJ, and other DNA helicases in the metabolism of damaged DNA that can interfere with basic cellular processes of DNA metabolism. JF - The Journal of biological chemistry AU - Suhasini, Avvaru N AU - Sommers, Joshua A AU - Mason, Aaron C AU - Voloshin, Oleg N AU - Camerini-Otero, R Daniel AU - Wold, Marc S AU - Brosh, Robert M AD - Laboratory of Molecular Gerontology, Biomedical Research Center, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2009/07/03/ PY - 2009 DA - 2009 Jul 03 SP - 18458 EP - 18470 VL - 284 IS - 27 KW - BACH1 protein, human KW - 0 KW - Basic-Leucine Zipper Transcription Factors KW - DNA Adducts KW - Fanconi Anemia Complementation Group Proteins KW - RPA1 protein, human KW - Replication Protein A KW - thymine glycol KW - 2943-56-8 KW - 8-hydroxyguanine KW - 5614-64-2 KW - Guanine KW - 5Z93L87A1R KW - DNA KW - 9007-49-2 KW - DNA Helicases KW - EC 3.6.4.- KW - Thymine KW - QR26YLT7LT KW - Index Medicus KW - Breast Neoplasms -- genetics KW - DNA Adducts -- genetics KW - Thymine -- analogs & derivatives KW - Thymine -- metabolism KW - DNA Helicases -- metabolism KW - Humans KW - Enzyme Activation -- physiology KW - DNA Adducts -- metabolism KW - Guanine -- metabolism KW - DNA Helicases -- genetics KW - Guanine -- analogs & derivatives KW - Substrate Specificity KW - Fanconi Anemia -- genetics KW - Female KW - Fanconi Anemia Complementation Group Proteins -- metabolism KW - Fanconi Anemia Complementation Group Proteins -- genetics KW - DNA Damage -- physiology KW - DNA -- genetics KW - Basic-Leucine Zipper Transcription Factors -- metabolism KW - Oxidative Stress -- genetics KW - Replication Protein A -- genetics KW - Basic-Leucine Zipper Transcription Factors -- genetics KW - Replication Protein A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67429814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=FANCJ+helicase+uniquely+senses+oxidative+base+damage+in+either+strand+of+duplex+DNA+and+is+stimulated+by+replication+protein+A+to+unwind+the+damaged+DNA+substrate+in+a+strand-specific+manner.&rft.au=Suhasini%2C+Avvaru+N%3BSommers%2C+Joshua+A%3BMason%2C+Aaron+C%3BVoloshin%2C+Oleg+N%3BCamerini-Otero%2C+R+Daniel%3BWold%2C+Marc+S%3BBrosh%2C+Robert+M&rft.aulast=Suhasini&rft.aufirst=Avvaru&rft.date=2009-07-03&rft.volume=284&rft.issue=27&rft.spage=18458&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.012229 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-27 N1 - Date created - 2009-06-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 2000 Feb 8;39(5):850-9 [10653628] Mol Cell. 2002 Sep;10(3):647-57 [12408831] Annu Rev Biochem. 2000;69:651-97 [10966472] Cell. 2001 Apr 6;105(1):149-60 [11301010] J Biol Chem. 2001 Nov 30;276(48):45367-71 [11571287] J Biol Chem. 2002 Jun 28;277(26):23236-45 [11956187] Free Radic Biol Med. 2002 Jul 1;33(1):1-14 [12086677] J Biol Chem. 2003 Jan 17;278(3):1424-32 [12419808] J Biol Chem. 2003 Jul 25;278(30):28284-93 [12748189] Mol Biol Cell. 2004 Feb;15(2):734-50 [14657243] Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2357-62 [14983014] Nucleic Acids Res. 2004;32(7):2158-70 [15096578] Bioessays. 1994 Jan;16(1):13-22 [8141804] Biochemistry. 1994 Nov 29;33(47):14197-206 [7947831] J Bacteriol. 1995 Oct;177(19):5612-21 [7559350] J Biol Chem. 1997 Apr 4;272(14):9227-36 [9083056] Annu Rev Biochem. 1997;66:61-92 [9242902] J Biol Chem. 1999 May 21;274(21):14972-8 [10329699] J Biol Chem. 1999 Jun 25;274(26):18341-50 [10373438] Hum Mol Genet. 2005 Mar 1;14(5):693-701 [15661754] Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):128-42 [15668941] J Biol Chem. 2005 Jul 8;280(27):25450-60 [15878853] J Biol Chem. 2005 Jul 29;280(30):28072-84 [15899892] Nat Genet. 2005 Sep;37(9):953-7 [16116421] Nat Genet. 2005 Sep;37(9):934-5 [16116423] Nat Genet. 2005 Sep;37(9):931-3 [16116424] Cancer Cell. 2005 Sep;8(3):255-65 [16153896] Genes Dev. 2006 Jan 1;20(1):34-46 [16391231] Oncogene. 2006 Apr 6;25(15):2245-53 [16462773] Cell Oncol. 2006;28(1-2):3-29 [16675878] Blood. 2006 Jun 1;107(11):4223-33 [16493006] Biochem J. 2006 Sep 15;398(3):319-37 [16925525] J Mol Biol. 2006 Sep 8;362(1):18-25 [16890954] Mol Cell. 2006 Sep 15;23(6):801-8 [16973432] Nat Genet. 2006 Nov;38(11):1239-41 [17033622] Nucleic Acids Res. 2006;34(22):6673-83 [17145708] DNA Repair (Amst). 2007 Apr 1;6(4):470-80 [17116430] J Biol Chem. 2007 Jun 22;282(25):18437-47 [17416902] Mol Cell Biol. 2007 Oct;27(19):6733-41 [17664283] Nat Rev Genet. 2007 Oct;8(10):735-48 [17768402] Blood. 2007 Oct 1;110(7):2390-8 [17596542] Cell Cycle. 2008 Apr 15;7(8):989-1000 [18414032] Mol Cell Biol. 2008 Jun;28(12):4116-28 [18426915] J Biol Chem. 2008 Jul 4;283(27):19095-111 [18469000] Clin Cancer Res. 2008 Jul 15;14(14):4672-80 [18628483] Antioxid Redox Signal. 2008 Nov;10(11):1909-21 [18627348] DNA Repair (Amst). 2008 Dec 1;7(12):1973-81 [18786657] J Biol Chem. 2000 Aug 4;275(31):23500-8 [10825162] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.012229 ER - TY - JOUR T1 - Ensemble approach to predict specificity determinants: benchmarking and validation. AN - 67523002; 19573245 AB - It is extremely important and challenging to identify the sites that are responsible for functional specification or diversification in protein families. In this study, a rigorous comparative benchmarking protocol was employed to provide a reliable evaluation of methods which predict the specificity determining sites. Subsequently, three best performing methods were applied to identify new potential specificity determining sites through ensemble approach and common agreement of their prediction results. It was shown that the analysis of structural characteristics of predicted specificity determining sites might provide the means to validate their prediction accuracy. For example, we found that for smaller distances it holds true that the more reliable the prediction method is, the closer predicted specificity determining sites are to each other and to the ligand. We observed certain similarities of structural features between predicted and actual subsites which might point to their functional relevance. We speculate that majority of the identified potential specificity determining sites might be indirectly involved in specific interactions and could be ideal target for mutagenesis experiments. JF - BMC bioinformatics AU - Chakrabarti, Saikat AU - Panchenko, Anna R AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA. chakraba@ncbi.nlm.nih.gov Y1 - 2009/07/02/ PY - 2009 DA - 2009 Jul 02 SP - 207 VL - 10 KW - Proteins KW - 0 KW - Index Medicus KW - Models, Molecular KW - Databases, Protein KW - Computational Biology -- methods KW - Benchmarking KW - Protein Conformation KW - Binding Sites KW - Proteins -- chemistry KW - Sequence Alignment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67523002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+bioinformatics&rft.atitle=Ensemble+approach+to+predict+specificity+determinants%3A+benchmarking+and+validation.&rft.au=Chakrabarti%2C+Saikat%3BPanchenko%2C+Anna+R&rft.aulast=Chakrabarti&rft.aufirst=Saikat&rft.date=2009-07-02&rft.volume=10&rft.issue=&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=BMC+bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-10-207 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-22 N1 - Date created - 2009-07-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bioinformatics. 2006 Jan 15;22(2):164-71 [16278237] Nucleic Acids Res. 2005;33(14):4455-65 [16085755] Bioinformatics. 2006 Oct 15;22(20):2466-74 [16870932] Nucleic Acids Res. 2006;34(22):6540-8 [17130172] BMC Evol Biol. 2007;7 Suppl 1:S12 [17288570] BMC Bioinformatics. 2007;8:135 [17451607] PLoS Comput Biol. 2007 Aug;3(8):e160 [17708678] J Mol Biol. 2007 Oct 26;373(3):801-10 [17868687] Bioinformatics. 2008 Jan 1;24(1):18-25 [18024975] Genome Biol. 2007;8(11):R232 [17976239] Bioinformatics. 2008 Jul 1;24(13):1473-80 [18450811] Proteins. 2009 Apr;75(1):231-40 [18831050] Bioinformatics. 2009 Jun 1;25(11):1426-7 [19307237] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] Mol Biol Evol. 1999 Dec;16(12):1664-74 [10605109] J Mol Biol. 2000 Oct 13;303(1):61-76 [11021970] Mol Biol Evol. 2001 Apr;18(4):453-64 [11264396] Nucleic Acids Res. 2001 Jul 15;29(14):2994-3005 [11452024] J Mol Biol. 2002 Aug 2;321(1):7-20 [12139929] J Mol Biol. 2003 Feb 28;326(4):1289-302 [12589769] Protein Sci. 2004 Feb;13(2):443-56 [14739328] Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W424-8 [15215423] Science. 1981 Oct 9;214(4517):149-59 [7280687] J Mol Biol. 1996 Mar 29;257(2):342-58 [8609628] Bioinformatics. 1998;14(7):617-23 [9730927] Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W110-5 [16844971] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2105-10-207 ER - TY - JOUR T1 - GATA-1 associates with and inhibits p53. AN - 67450095; 19411634 AB - In addition to orchestrating the expression of all erythroid-specific genes, GATA-1 controls the growth, differentiation, and survival of the erythroid lineage through the regulation of genes that manipulate the cell cycle and apoptosis. The stages of mammalian erythropoiesis include global gene inactivation, nuclear condensation, and enucleation to yield circulating erythrocytes, and some of the genes whose expression are altered by GATA-1 during this process are members of the p53 pathway. In this study, we demonstrate a specific in vitro interaction between the transactivation domain of p53 (p53TAD) and a segment of the GATA-1 DNA-binding domain that includes the carboxyl-terminal zinc-finger domain. We also show by immunoprecipitation that the native GATA-1 and p53 interact in erythroid cells and that activation of p53-responsive promoters in an erythroid cell line can be inhibited by the overexpression of GATA-1. Mutational analysis reveals that GATA-1 inhibition of p53 minimally requires the segment of the GATA-1 DNA-binding domain that interacts with p53TAD. This inhibition is reciprocal, as the activation of a GATA-1-responsive promoter can be inhibited by p53. Based on these findings, we conclude that inhibition of the p53 pathway by GATA-1 may be essential for erythroid cell development and survival. JF - Blood AU - Trainor, Cecelia D AU - Mas, Caroline AU - Archambault, Patrick AU - Di Lello, Paola AU - Omichinski, James G AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ceceliat@mail.nih.gov Y1 - 2009/07/02/ PY - 2009 DA - 2009 Jul 02 SP - 165 EP - 173 VL - 114 IS - 1 KW - GATA1 Transcription Factor KW - 0 KW - GATA1 protein, human KW - Macromolecular Substances KW - Recombinant Fusion Proteins KW - TP53 protein, human KW - Tumor Suppressor Protein p53 KW - DNA KW - 9007-49-2 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - DNA -- metabolism KW - Humans KW - Cell Differentiation KW - Mice KW - Cell Line, Tumor KW - Transcriptional Activation KW - Recombinant Fusion Proteins -- chemistry KW - Binding Sites KW - Cell Survival KW - Recombinant Fusion Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Erythroid Cells -- cytology KW - Nuclear Magnetic Resonance, Biomolecular KW - In Vitro Techniques KW - Recombinant Fusion Proteins -- genetics KW - DNA -- chemistry KW - Zinc Fingers KW - Erythroid Cells -- metabolism KW - Protein Interaction Domains and Motifs KW - GATA1 Transcription Factor -- genetics KW - Tumor Suppressor Protein p53 -- antagonists & inhibitors KW - GATA1 Transcription Factor -- chemistry KW - Tumor Suppressor Protein p53 -- chemistry KW - Tumor Suppressor Protein p53 -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - GATA1 Transcription Factor -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67450095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+Yersinia+pestis+caf1M1A1+Fimbrial+Capsule+Operon+Promotes+Transmission+by+Flea+Bite+in+a+Mouse+Model+of+Bubonic+Plague&rft.au=Sebbane%2C+Florent%3BJarrett%2C+Clayton%3BGardner%2C+Donald%3BLong%2C+Daniel%3BHinnebusch%2C+BJoseph&rft.aulast=Sebbane&rft.aufirst=Florent&rft.date=2009-03-01&rft.volume=77&rft.issue=3&rft.spage=1222&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-24 N1 - Date created - 2009-07-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Mar 12;279(11):10523-31 [14701820] Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):980-5 [14715908] Proc Natl Acad Sci U S A. 1988 Aug;85(16):5976-80 [3413070] Nature. 1989 Jun 8;339(6224):446-51 [2725678] Nature. 1991 Jan 17;349(6306):257-60 [1987478] Genes Dev. 1990 Nov;4(11):1886-98 [2276623] Nucleic Acids Res. 1991 May 11;19(9):2499 [2041787] Genes Dev. 1991 Jun;5(6):919-31 [2044960] Science. 1993 Jul 23;261(5120):438-46 [8332909] Cell. 1995 Jan 27;80(2):293-9 [7834749] Science. 1995 Mar 10;267(5203):1506-10 [7878471] Nature. 1995 Jun 22;375(6533):694-8 [7791904] Cell. 1995 Jul 14;82(1):29-36 [7606782] Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9623-7 [7568185] Mol Cell Biol. 1996 May;16(5):2238-47 [8628290] Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12355-8 [8901585] Cell. 1997 Jul 11;90(1):109-19 [9230307] EMBO J. 1997 Jul 1;16(13):3965-73 [9233806] Blood. 1998 Jul 15;92(2):434-42 [9657742] Nature. 1998 Dec 10;396(6711):594-8 [9859997] Mol Cell Biol. 1999 May;19(5):3496-505 [10207073] Genes Dev. 1999 Jun 1;13(11):1398-411 [10364157] Blood. 1999 Jul 1;94(1):87-96 [10381501] EMBO J. 1999 Jul 15;18(14):4035-48 [10406808] Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8705-10 [10411939] Blood. 2004 Nov 15;104(10):3136-47 [15297311] Semin Cell Dev Biol. 2005 Feb;16(1):137-47 [15659348] Mol Cell. 2005 Feb 4;17(3):453-62 [15694345] J Biol Chem. 2005 Jun 10;280(23):22385-94 [15817467] Mol Cell Biol. 2005 Sep;25(17):7423-31 [16107691] Mol Cell. 2006 Jun 23;22(6):731-40 [16793543] EMBO J. 2006 Jul 26;25(14):3264-74 [16858405] Blood. 2007 Mar 15;109(6):2630-3 [17105817] Mol Cell. 2008 Feb 1;29(2):232-42 [18243117] Nat Rev Cancer. 2008 Apr;8(4):279-87 [18354416] Cell Stem Cell. 2007 Oct 11;1(4):416-27 [18371378] Blood. 2009 Mar 19;113(12):2619-28 [19139078] Nature. 1992 Mar 19;356(6366):215-21 [1552940] Blood. 2000 Apr 15;95(8):2543-51 [10753833] Science. 2000 May 12;288(5468):1053-8 [10807576] J Biol Chem. 2001 Sep 21;276(38):35794-801 [11445591] J Exp Med. 2002 Jun 3;195(11):1387-95 [12045237] J Exp Med. 2003 Feb 3;197(3):281-96 [12566412] Mol Cell Biol. 2003 Jul;23(14):5031-42 [12832487] Oncogene. 2003 Jul 24;22(30):4648-55 [12879009] Cancer Res. 2003 Oct 1;63(19):6363-9 [14559825] Mol Cell Biol. 2003 Nov;23(21):7460-74 [14559995] J Biol Chem. 2003 Nov 14;278(46):45620-8 [12941967] Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):476-81 [14695898] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8870-5 [15173587] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2008-10-180489 ER - TY - JOUR T1 - Management of the N0 neck in moderately advanced squamous carcinoma of the larynx. AN - 85384544; pmid-19559959 AB - To assess the oncological efficacy of selective neck dissection (SND) in patients with T3-4 N0 laryngeal squamous carcinoma.A total of 327 patients underwent 654 neck dissections; each side of the neck was individually evaluated.Three percent of patients who had SND developed regional recurrence (RR) in comparison with 11.7 percent of patients who underwent modified radical neck dissection (MRND) (P=0.005). Only 3 (0.9%) patients developed RR outside the field of SND. The presence of extracapsular extension (P=0.002) in node-positive (pN+) group and of microvascular invasion (P=0.007), together with the type of neck dissection (ND) (P=0.0003) in node-negative (pN0) group had statistical impact on RR. The development of RR significantly affected disease-specific survival (P=0.0001). Equivalent rates of RR were found in pN+ (2.6%) or pN0 (3.2%) patients treated with SND (P=0.98) as well as in pN+ patients who underwent SND (2.6%) or MRND (4.7%) (P=0.85).This study confirmed the adequacy of SND as a satisfactory staging and therapeutic procedure, and suggests its use in the treatment of limited node-positive (N+) neck. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Dias, Fernando L AU - Lima, Roberto A AU - Manfro, Gabriel AU - Barbosa, Mauro M AU - Salviano, Scheilla AU - Rocha, Ricardo M AU - Marques, Amanda S AU - Cernea, Cláudio R AU - Kligerman, Jacob AD - Department of Head and Neck Surgery, Brazilian National Cancer Institute, Rio de Janeiro, Brazil. fdias@inca.gov.br Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 59 EP - 65 VL - 141 IS - 1 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - *Carcinoma, Squamous Cell: pathology KW - *Carcinoma, Squamous Cell: surgery KW - Female KW - Humans KW - *Laryngeal Neoplasms: pathology KW - *Laryngeal Neoplasms: surgery KW - *Laryngectomy: methods KW - Lymphatic Metastasis KW - Male KW - Middle Aged KW - *Neck Dissection: methods KW - Neoplasm Invasiveness KW - Neoplasm Recurrence, Local KW - Neoplasm Staging KW - Retrospective Studies KW - Survival Analysis KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85384544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Management+of+the+N0+neck+in+moderately+advanced+squamous+carcinoma+of+the+larynx.&rft.au=Dias%2C+Fernando+L%3BLima%2C+Roberto+A%3BManfro%2C+Gabriel%3BBarbosa%2C+Mauro+M%3BSalviano%2C+Scheilla%3BRocha%2C+Ricardo+M%3BMarques%2C+Amanda+S%3BCernea%2C+Cl%C3%A1udio+R%3BKligerman%2C+Jacob&rft.aulast=Dias&rft.aufirst=Fernando&rft.date=2009-07-01&rft.volume=141&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Tick-borne Relapsing Fever and Borrelia hermsii, Los Angeles County, California, USA AN - 745641151; 13135286 AB - The primary cause of tick-borne relapsing fever in western North America is Borrelia hermsii, a rodent-associated spirochete transmitted by the fast-feeding soft tick Ornithodoros hermsi. We describe a patient who had an illness consistent with relapsing fever after exposure in the mountains near Los Angeles, California, USA. The patient's convalescent-phase serum was seropositive for B. hermsii but negative for several other vector-borne bacterial pathogens. Investigations at the exposure site showed the presence of O. hermsi ticks infected with B. hermsii and the presence of rodents that were seropositive for the spirochete. We determined that this tick-borne disease is endemic to the San Gabriel Mountains near the greater Los Angeles metropolitan area. JF - Emerging Infectious Diseases AU - Schwan, T G AU - Raffel, S J AU - Schrumpf, ME AU - Webster, L S AU - Marques, A R AU - Spano, R AU - Rood, M AU - Burns, J AU - Hu, R AD - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA Y1 - 2009/07// PY - 2009 DA - Jul 2009 VL - 15 IS - 7 SN - 1080-6040, 1080-6040 KW - Microbiology Abstracts B: Bacteriology KW - Mountains KW - Spirochetes KW - Borrelia hermsii KW - Ixodidae KW - Relapsing fever KW - tick-borne diseases KW - Pathogens KW - Ornithodoros KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745641151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Tick-borne+Relapsing+Fever+and+Borrelia+hermsii%2C+Los+Angeles+County%2C+California%2C+USA&rft.au=Schwan%2C+T+G%3BRaffel%2C+S+J%3BSchrumpf%2C+ME%3BWebster%2C+L+S%3BMarques%2C+A+R%3BSpano%2C+R%3BRood%2C+M%3BBurns%2C+J%3BHu%2C+R&rft.aulast=Schwan&rft.aufirst=T&rft.date=2009-07-01&rft.volume=15&rft.issue=7&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mountains; Spirochetes; Relapsing fever; tick-borne diseases; Pathogens; Borrelia hermsii; Ixodidae; Ornithodoros ER - TY - JOUR T1 - Effects of race and socioeconomic status on the relative influence of education and literacy on cognitive functioning. AN - 742779460; pmid-19573276 AB - Previous research has shown that reading ability is a stronger predictor of cognitive functioning than years of education, particularly for African Americans. The current study was designed to determine whether the relative influence of literacy and education on cognitive abilities varies as a function of race or socioeconomic status (SES). We examined the unique influence of education and reading scores on a range of cognitive tests in low- and higher-SES African Americans and Whites. Literacy significantly predicted scores on all but one cognitive measure in both African American groups and low-SES Whites, while education was not significantly associated with any cognitive measure. In contrast, both education and reading scores predicted performance on many cognitive measures in higher-SES Whites. These findings provide further evidence that reading ability better predicts cognitive functioning than years of education and suggest that disadvantages associated with racial minority status and low SES affect the relative influence of literacy and years of education on cognition. JF - Journal of the International Neuropsychological Society : JINS AU - Dotson, Vonetta M AU - Kitner-Triolo, Melissa H AU - Evans, Michele K AU - Zonderman, Alan B AD - Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Room #04B316, Baltimore, Maryland 21224, USA. dotsonv@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 580 EP - 589 VL - 15 IS - 4 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Educational Status KW - Reading KW - Humans KW - Adult KW - Cross-Cultural Comparison KW - Middle Aged KW - Predictive Value of Tests KW - Statistics as Topic KW - Neuropsychological Tests KW - Male KW - Female KW - Cognition -- physiology KW - Social Class KW - African Americans -- psychology KW - European Continental Ancestry Group -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742779460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Effects+of+race+and+socioeconomic+status+on+the+relative+influence+of+education+and+literacy+on+cognitive+functioning.&rft.au=Dotson%2C+Vonetta+M%3BKitner-Triolo%2C+Melissa+H%3BEvans%2C+Michele+K%3BZonderman%2C+Alan+B&rft.aulast=Dotson&rft.aufirst=Vonetta&rft.date=2009-07-01&rft.volume=15&rft.issue=4&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-07-15 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Amplifying effect of a release mechanism for fast adaptation in the hair bundle. AN - 742779077; pmid-19603855 AB - A "release" mechanism, which has been experimentally observed as the fast component in the hair bundle's response to mechanical stimulation, appears similar to common mechanical relaxation with a damping effect. This observation is puzzling because such a response is expected to have an amplifying role in the mechanoelectrical transduction process in hair cells. Here it is shown that a release mechanism can indeed have a role in amplification, if it is associated with negative stiffness due to the gating of the mechonoelectric transducer channel. JF - The Journal of the Acoustical Society of America AU - Sul, Bora AU - Iwasa, Kuni H AD - Section on Biophysics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland 20850-3211, USA. sulb@nidcd.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 4 EP - 6 VL - 126 IS - 1 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Algorithms KW - Adaptation, Physiological KW - Physical Stimulation KW - Elasticity KW - Hair Cells, Auditory -- physiology KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742779077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Amplifying+effect+of+a+release+mechanism+for+fast+adaptation+in+the+hair+bundle.&rft.au=Sul%2C+Bora%3BIwasa%2C+Kuni+H&rft.aulast=Sul&rft.aufirst=Bora&rft.date=2009-07-01&rft.volume=126&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-07-08 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Evaluation of the thyroid in patients with hearing loss and enlarged vestibular aqueducts. AN - 742778518; pmid-19620588 AB - OBJECTIVE: To evaluate thyroid structure and function in patients with enlargement of the vestibular aqueduct (EVA) and sensorineural hearing loss. DESIGN: Prospective cohort survey. SETTING: National Institutes of Health Clinical Center, a federal biomedical research facility. PATIENTS: The study population comprised 80 individuals, aged 1.5 to 59 years, ascertained on the basis of EVA and sensorineural hearing loss. MAIN OUTCOME MEASURES: Associations among the number of mutant alleles of SLC26A4; volume and texture of the thyroid; percentage of iodine 123 ((123)I) discharged at 120 minutes after administration of perchlorate in the perchlorate discharge test; and peripheral venous blood levels of thyrotropin, thyroxine, free thyroxine, triiodothyronine, thyroglobulin, antithyroid peroxidase and antithyroglobulin antibodies, and thyroid-binding globulin. RESULTS: Thyroid volume is primarily genotype dependent in pediatric patients but age dependent in older patients. Individuals with 2 mutant SLC26A4 alleles discharged a significantly (P < or = .001) greater percentage of (123)I compared with those with no mutant alleles or 1 mutant allele. Thyroid function, as measured by serologic testing, is not associated with the number of mutant alleles. CONCLUSIONS: Ultrasonography with measurement of gland volume is recommended for initial assessment and follow-up surveillance of the thyroid in patients with EVA. Perchlorate discharge testing is recommended for the diagnostic evaluation of patients with EVA along with goiter, nondiagnostic SLC26A4 genotypes (zero or 1 mutant allele), or both. JF - Archives of otolaryngology--head & neck surgery AU - Madeo, Anne C AU - Manichaikul, Ani AU - Reynolds, James C AU - Sarlis, Nicholas J AU - Pryor, Shannon P AU - Shawker, Thomas H AU - Griffith, Andrew J AD - Social and Behavioral Research Branch, National Human GenomeResearch Institute, National Institutes of Health, Bethesda, MD 20892-3320, USA. Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 670 EP - 676 VL - 135 IS - 7 SN - 0886-4470, 0886-4470 KW - National Library of Medicine KW - Hearing Loss, Sensorineural -- physiopathology KW - Young Adult KW - Hearing Loss, Sensorineural -- genetics KW - Perchloric Acid -- diagnostic use KW - Humans KW - Goiter -- genetics KW - Thyroid Function Tests KW - Child KW - Child, Preschool KW - Infant KW - Prospective Studies KW - Adult KW - Middle Aged KW - Adolescent KW - Membrane Transport Proteins -- genetics KW - Vestibular Aqueduct -- pathology KW - Thyroid Gland -- ultrasonography KW - Thyroid Gland -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742778518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+otolaryngology--head+%26+neck+surgery&rft.atitle=Evaluation+of+the+thyroid+in+patients+with+hearing+loss+and+enlarged+vestibular+aqueducts.&rft.au=Madeo%2C+Anne+C%3BManichaikul%2C+Ani%3BReynolds%2C+James+C%3BSarlis%2C+Nicholas+J%3BPryor%2C+Shannon+P%3BShawker%2C+Thomas+H%3BGriffith%2C+Andrew+J&rft.aulast=Madeo&rft.aufirst=Anne&rft.date=2009-07-01&rft.volume=135&rft.issue=7&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=Archives+of+otolaryngology--head+%26+neck+surgery&rft.issn=08864470&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Autobiographical Memory Phenomenology and Content Mediate Attachment Style and Psychological Distress AN - 742720081; 201012063 AB - In 2 studies, the present research tested the phenomenology and content of autobiographical memory as distinct mediators between attachment avoidance and anxiety and depressive symptoms. In Study 1, participants (N = 454) completed measures of attachment and depressive symptoms in 1 session and retrieved and rated 2 self-defining memories of romantic relationships in a separate session. In Study 2, participants (N = 534) were primed with attachment security, attachment insecurity, or a control prime and then retrieved and rated a self-defining relationship memory. Memory phenomenology, specifically memory coherence and emotional intensity, mediated the association between attachment avoidance and depressive symptoms, whereas the negative affective content of the memory mediated the association between attachment anxiety and depressive symptoms. Priming attachment security led to retrieval of a more coherent relationship memory, whereas insecurity led to the retrieval of a more incoherent relationship memory. Discussion focuses on the construction and recollection of memories as underlying mechanisms of adult attachment and psychological distress, the importance of memory coherence, and the implications for counseling research and practice. [Copyright The American Psychological Association.] JF - Journal of Counseling Psychology AU - Sutin, Angelina R AU - Gillath, Omri AD - Department of Psychology, University of California, Davis sutina@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 351 EP - 364 PB - American Psychological Association, Washington DC VL - 56 IS - 3 SN - 0022-0167, 0022-0167 KW - adult attachment autobiographical memory depression phenomenology coherence KW - Coherence KW - Depression KW - Attachment KW - Phenomenology KW - Memories KW - Autobiographical memory KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742720081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Counseling+Psychology&rft.atitle=Autobiographical+Memory+Phenomenology+and+Content+Mediate+Attachment+Style+and+Psychological+Distress&rft.au=Sutin%2C+Angelina+R%3BGillath%2C+Omri&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2009-07-01&rft.volume=56&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Journal+of+Counseling+Psychology&rft.issn=00220167&rft_id=info:doi/10.1037%2Fa0014917 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Memories; Attachment; Depression; Phenomenology; Autobiographical memory; Coherence DO - http://dx.doi.org/10.1037/a0014917 ER - TY - JOUR T1 - Prostvac-VF: a vector-based vaccine targeting PSA in prostate cancer. AN - 733361083; 19548854 AB - Prostvac is a prostate cancer vaccine regimen consisting of a recombinant vaccinia vector as a primary vaccination, followed by multiple booster vaccinations employing a recombinant fowlpox vector. Both vectors contain the transgenes for prostate-specific antigen (PSA) and multiple T-cell co-stimulatory molecules (TRICOM). The PSA-TRICOM vaccines infect antigen-presenting cells (APCs) and generate proteins that are expressed on the surface of the APCs in an immune context. The interaction of these APCs with T cells initiates a targeted immune response and T cell-mediated tumor cell destruction. Preliminary clinical trials have indicated negligible toxicity, and Phase II trials have suggested a survival benefit after treatment with Prostvac, especially in patients with indolent disease characteristics. Preclinical and clinical data indicate that radiation, hormonal therapy, and chemotherapy may be combined with Prostvac to enhance the vaccine's efficacy. Additional strategies are in development to further enhance the clinical benefits of Prostvac, and a Phase III trial is being planned in metastatic castration-resistant prostate cancer. JF - Expert opinion on investigational drugs AU - Madan, Ravi A AU - Arlen, Philip M AU - Mohebtash, Mahsa AU - Hodge, James W AU - Gulley, James L AD - National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Tumor Immunology and Biology, Bethesda, MD 20892, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1001 EP - 1011 VL - 18 IS - 7 KW - Cancer Vaccines KW - 0 KW - PROSTVAC KW - Vaccines, Synthetic KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - Animals KW - Immunization, Secondary -- methods KW - Clinical Trials, Phase II as Topic -- trends KW - Humans KW - Vaccines, Synthetic -- immunology KW - Vaccines, Synthetic -- administration & dosage KW - Immunization, Secondary -- trends KW - Male KW - Clinical Trials, Phase II as Topic -- methods KW - Genetic Vectors -- administration & dosage KW - Cancer Vaccines -- administration & dosage KW - Cancer Vaccines -- immunology KW - Gene Targeting -- methods KW - Prostate-Specific Antigen -- antagonists & inhibitors KW - Genetic Vectors -- immunology KW - Cancer Vaccines -- genetics KW - Prostate-Specific Antigen -- immunology KW - Prostatic Neoplasms -- genetics KW - Prostatic Neoplasms -- prevention & control KW - Gene Targeting -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733361083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Redox+warfare+between+airway+epithelial+cells+and+Pseudomonas%3A+dual+oxidase+versus+pyocyanin&rft.au=Rada%2C+Balazs%3BLeto%2C+Thomas+L&rft.aulast=Rada&rft.aufirst=Balazs&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8071-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-04 N1 - Date created - 2009-06-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 1996 Jul 1;88(1):202-10 [8704175] Crit Rev Immunol. 1995;15(3-4):235-53 [8834450] J Natl Cancer Inst. 1997 Feb 19;89(4):293-300 [9048833] Vaccine. 1997 Apr-May;15(6-7):759-68 [9178479] Blood. 1997 Sep 15;90(6):2188-95 [9310469] J Clin Oncol. 1997 Oct;15(10):3266-74 [9336364] Int J Cancer. 1997 Nov 27;73(5):757-62 [9398058] Immunol Rev. 1998 Jun;163:151-60 [9700508] J Immunol. 2005 Aug 15;175(4):2741-53 [16081852] J Immunol. 2005 Sep 15;175(6):3715-23 [16148117] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18538-43 [16344461] Transplantation. 2005 Dec 15;80(11):1604-13 [16371932] Clin Cancer Res. 2006 Feb 15;12(4):1260-9 [16489082] Expert Rev Vaccines. 2006 Apr;5(2):199-209 [16608420] Oncol Rep. 2006 Jul;16(1):141-6 [16786137] J Clin Oncol. 2006 Jul 1;24(19):3089-94 [16809734] Front Biosci. 2007;12:4957-71 [17569623] Clin Cancer Res. 2007 Jul 1;13(13):3776-82 [17606707] Clin Cancer Res. 2007 Jul 1;13(13):3883-91 [17606721] J Urol. 2007 Oct;178(4 Pt 1):1515-20 [17707059] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Clin Cancer Res. 2008 Jul 15;14(14):4526-31 [18628467] Clin Cancer Res. 2008 Aug 15;14(16):5284-91 [18698048] Cancer. 2008 Sep 1;113(5):975-84 [18646045] Oncology (Williston Park). 2008 Aug;22(9):1064-70; 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AN - 733218803; 19361554 JF - Free radical biology & medicine AU - Levine, Mark AU - Espey, Michael Graham AU - Chen, Qi AD - Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1372, USA. MarkL@mail.nih.gov Y1 - 2009/07/01/ PY - 2009 DA - 2009 Jul 01 SP - 27 EP - 29 VL - 47 IS - 1 KW - Organic Anion Transporters, Sodium-Dependent KW - 0 KW - Sodium-Coupled Vitamin C Transporters KW - Symporters KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Animals KW - Humans KW - Symporters -- genetics KW - Nutrition Policy KW - Clinical Trials as Topic KW - Mice KW - Cell Death -- drug effects KW - Cell Growth Processes -- genetics KW - Mice, Knockout KW - Cell Growth Processes -- drug effects KW - Organic Anion Transporters, Sodium-Dependent -- genetics KW - Drug Synergism KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology KW - Ascorbic Acid -- analogs & derivatives KW - Neoplasms -- physiopathology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Ascorbic Acid -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733218803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Losing+and+finding+a+way+at+C%3A+new+promise+for+pharmacologic+ascorbate+in+cancer+treatment.&rft.au=Levine%2C+Mark%3BEspey%2C+Michael+Graham%3BChen%2C+Qi&rft.aulast=Levine&rft.aufirst=Mark&rft.date=2009-07-01&rft.volume=47&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2009.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-17 N1 - Date created - 2009-06-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9 [18678913] Proc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54 [17502596] Cancer Res. 2008 Oct 1;68(19):8031-8 [18829561] Ann Oncol. 2008 Nov;19(11):1969-74 [18544557] Free Radic Biol Med. 2009 Jul 1;47(1):32-40 [19254759] J Am Coll Nutr. 2000 Aug;19(4):423-5 [10963459] Antioxid Redox Signal. 2001 Feb;3(1):157-63 [11291594] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9842-6 [11504949] Am J Clin Nutr. 2002 Apr;75(4):616-58 [11916749] Nat Med. 2002 May;8(5):514-7 [11984597] Apoptosis. 2004 Mar;9(2):223-33 [15004519] Ann Intern Med. 2004 Apr 6;140(7):533-7 [15068981] Science. 1968 Apr 19;160(3825):265-71 [5641253] Lancet. 1972 Mar 4;1(7749):542 [4110043] Chem Biol Interact. 1975 Nov;11(5):387-93 [1104207] Proc Natl Acad Sci U S A. 1976 Oct;73(10):3685-9 [1068480] Proc Natl Acad Sci U S A. 1978 Sep;75(9):4538-42 [279931] N Engl J Med. 1979 Sep 27;301(13):687-90 [384241] N Engl J Med. 1985 Jan 17;312(3):137-41 [3880867] N Engl J Med. 1985 Jan 17;312(3):178-9 [3965937] N Engl J Med. 1986 Apr 3;314(14):892-902 [3513016] J Biol Chem. 1989 Sep 15;264(26):15404-9 [2768269] Am J Clin Nutr. 1991 Dec;54(6 Suppl):1157S-1162S [1962564] Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3704-9 [8623000] Pharm Res. 1997 Sep;14(9):1133-9 [9327438] Am J Physiol. 1951 Apr 1;165(1):61-5 [14829572] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9 [16157892] CMAJ. 2006 Mar 28;174(7):937-42 [16567755] Biochem Pharmacol. 2006 Sep 14;72(6):671-80 [16828058] Comment On: Free Radic Biol Med. 2009 Jul 1;47(1):32-40 [19254759] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2009.04.001 ER - TY - JOUR T1 - New onset somnambulism associated with different dosage of mirtazapine: a case report. AN - 67537027; 19644232 AB - Somnambulism consists of variously complex behaviors that may result in harm to self or to others. Many different medications have been reported to induce somnambulism, and a few of them are newer antidepressants. A 40-year-old woman with history of major depression who experienced new onset somnambulism for successive 3 nights, whereas the antidepressant mirtazapine was increased from 30 to 45 mg/d. The notable and complex sleepwalking symptoms terminated dramatically on the first night after withdrawal of mirtazapine. There is clearly a cause-and-effect relationship between the treatment of higher-dosage mirtazapine and development of somnambulism. It might be related to the different affinities to 5-hydroxytryptamine 2 (5-HT(2)) and H(1) receptors at different dosages of mirtazapine, which explain the patient experiencing sleepwalking episodes exclusively at higher doses of mirtazapine. Clinical physicians should be aware of this adverse effect and taper or discontinue the regimen if sleepwalking develops. JF - Clinical neuropharmacology AU - Yeh, Yi-Wei AU - Chen, Chun-Hsiung AU - Feng, Hui-Ming AU - Wang, Sheng-Chiang AU - Kuo, Shin-Chang AU - Chen, Chih-Kang AD - Department of Psychiatry, Tri-Service General Hospital, Nei-Hu Area, Taipei, Taiwan. PY - 2009 SP - 232 EP - 233 VL - 32 IS - 4 KW - Antidepressive Agents, Tricyclic KW - 0 KW - Mianserin KW - 250PJI13LM KW - mirtazapine KW - A051Q2099Q KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Female KW - Somnambulism -- psychology KW - Depressive Disorder, Major -- drug therapy KW - Mianserin -- adverse effects KW - Depressive Disorder, Major -- complications KW - Depressive Disorder, Major -- psychology KW - Antidepressive Agents, Tricyclic -- adverse effects KW - Somnambulism -- chemically induced KW - Mianserin -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67537027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=How+human+leukocytes+track+down+and+destroy+pathogens%3A+lessons+learned+from+the+model+organism+Dictyostelium+discoideum&rft.au=Jin%2C+Tian%3BXu%2C+Xuehua%3BFang%2C+Jun%3BIsik%2C+Nilgun%3BYan%2C+Jianshe%3BBrzostowski%2C+Joseph+A%3BHereld%2C+Dale&rft.aulast=Jin&rft.aufirst=Tian&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8056-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-08 N1 - Date created - 2009-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/WNF.0b013e318187bafc ER - TY - JOUR T1 - Helping patients who drink too much: an evidence-based guide for primary care clinicians. AN - 67509989; 19621845 AB - Excessive alcohol consumption is a leading cause of preventable morbidity and mortality, but few heavy drinkers receive treatment. Primary care physicians are in a position to address heavy drinking and alcohol use disorders with patients, and can do so quickly and effectively. The National Institute on Alcohol Abuse and Alcoholism has published a guide for physicians that offers an evidence-based approach to screening, assessing, and treating alcohol use disorders in general health care settings. Screening can be performed by asking patients how many heavy drinking days they have per week. Assessing patients' willingness to change their drinking behaviors can guide treatment. Treatment recommendations should be presented in a clear, nonjudgmental way. Patients who are not alcohol-dependent may opt to reduce drinking to lower risk levels. Patients with alcohol dependence should receive pharmacotherapy and brief behavioral support, as well as disease management for chronic relapsing dependence. All patients with alcohol dependence should be encouraged to participate in community support groups JF - American family physician AU - Willenbring, Mark L AU - Massey, Suena H AU - Gardner, Maureen B AD - National Institute on Alcohol Abuse adn Alcoholism, Bethesda, MD 20892, USA. mlw@niaaa.nih.gov Y1 - 2009/07/01/ PY - 2009 DA - 2009 Jul 01 SP - 44 EP - 50 VL - 80 IS - 1 SN - 0002-838X, 0002-838X KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Survival Rate KW - Humans KW - Morbidity -- trends KW - Physicians, Family KW - Alcoholism -- epidemiology KW - Alcoholism -- therapy KW - Evidence-Based Medicine -- methods KW - Practice Guidelines as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67509989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+family+physician&rft.atitle=Helping+patients+who+drink+too+much%3A+an+evidence-based+guide+for+primary+care+clinicians.&rft.au=Willenbring%2C+Mark+L%3BMassey%2C+Suena+H%3BGardner%2C+Maureen+B&rft.aulast=Willenbring&rft.aufirst=Mark&rft.date=2009-07-01&rft.volume=80&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=American+family+physician&rft.issn=0002838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-11 N1 - Date created - 2009-07-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am Fam Physician. 2009 Jul 1;80(1):21-2 [19621841] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adhesion- and migration-related side effects of phosphothioated CpG oligodeoxynucleotides. AN - 67496167; 19458479 AB - Nucleic acid oligodeoxynucleotides (ODN) are increasingly used in biological research and in clinics where they are used for both diagnostic and therapeutic purposes. In order to increase the stability and efficacy of ODNs, various chemical modifications have been applied to create nucleic acid derivatives that are not recognized by endogenous nucleic acid cleavage mechanisms. One of the most common and cost-effective modifications is the phosphothioate (PTO) modification. The PTO modification is implemented mainly in antisense ODN, but also in ODN that were shown to activate members of the toll-like receptor (TLR) family such as TLR3 (poly-I:C), TLR8 (ssRNA) and TLR9 (CpG). We recently found that PTO-ODN aimed at activating TLR9 induce a non-TLR9-specific detachment phenotype in a growth-substrate dependent manner. Moreover, we found that unmodified and PTO-modified TLR ligands induce distinct patterns of gene expression in cultured neural cells. These findings suggest that PTO-ODN can cause nonspecific effects on cell adhesion that could compromise interpretation of data from experiments using PTO-ODN. JF - Cell adhesion & migration AU - Okun, Eitan AU - Lathia, Justin D AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. okune@mail.nih.gov PY - 2009 SP - 272 EP - 274 VL - 3 IS - 3 KW - CPG-oligonucleotide KW - 0 KW - Oligodeoxyribonucleotides KW - Organothiophosphorus Compounds KW - Index Medicus KW - Extracellular Matrix -- drug effects KW - Animals KW - Transcription, Genetic -- drug effects KW - Extracellular Matrix -- metabolism KW - Cell Adhesion -- drug effects KW - Oligodeoxyribonucleotides -- adverse effects KW - Oligodeoxyribonucleotides -- pharmacology KW - Cell Movement -- drug effects KW - Organothiophosphorus Compounds -- pharmacology KW - Organothiophosphorus Compounds -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67496167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Understanding+B+cell+activation%3A+from+single+molecule+tracking%2C+through+Tolls%2C+to+stalking+memory+in+malaria&rft.au=Pierce%2C+Susan+K&rft.aulast=Pierce&rft.aufirst=Susan&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8052-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-19 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1980 Oct 2;287(5781):465-6 [7432474] Med Biol. 1984;62(3):163-80 [6387323] Dev Neurosci. 1985;7(5-6):308-22 [3879726] J Physiol (Paris). 1987;82(4):258-70 [3332689] J Neurosci Res. 2009 Jun;87(8):1947-52 [19156868] Trends Neurosci. 2005 Sep;28(9):480-6 [16043237] J Neurochem. 2006 Mar;96(5):1227-41 [16464240] J Comp Neurol. 2007 Dec 20;505(6):630-43 [17948866] J Neurosci Res. 2008 Aug 15;86(11):2363-75 [18381765] J Neurosci. 1991 Dec;11(12):3928-42 [1720815] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Appetite suppressants, cardiac valve disease and combination pharmacotherapy. AN - 67494287; 19092640 AB - The prevalence of obesity in the United States is a major health problem associated with significant morbidity, mortality, and economic burden. Although obesity and drug addiction are typically considered distinct clinical entities, both diseases involve dysregulation of biogenic amine neuron systems in the brain. Thus, research efforts to develop medications for treating drug addiction can contribute insights into the pharmacotherapy for obesity. Here, we review the neurochemical mechanisms of selected stimulant medications used in the treatment of obesity and issues related to fenfluramine-associated cardiac valvulopathy. In particular, we discuss the evidence that cardiac valve disease involves activation of mitogenic serotonin 2B (5-HT2B) receptors by norfenfluramine, the major metabolite of fenfluramine. Advances in medication discovery suggest that novel molecular entities that target 2 different neurochemical mechanisms, that is, "combination pharmacotherapy," will yield efficacious antiobesity medications with reduced adverse side effects. JF - American journal of therapeutics AU - Rothman, Richard B AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institutes of Health, National Institute on Drug Abuse, Department of Health and Human Services, Baltimore, MD 21224, USA. rrothman@mail.nih.gov PY - 2009 SP - 354 EP - 364 VL - 16 IS - 4 KW - Appetite Depressants KW - 0 KW - Receptor, Serotonin, 5-HT2B KW - Serotonin 5-HT2 Receptor Agonists KW - Norfenfluramine KW - 1886-26-6 KW - Fenfluramine KW - 2DS058H2CF KW - Phentermine KW - C045TQL4WP KW - Index Medicus KW - Drug Therapy, Combination KW - Norfenfluramine -- metabolism KW - Receptor, Serotonin, 5-HT2B -- metabolism KW - Dose-Response Relationship, Drug KW - Humans KW - Substance-Related Disorders -- drug therapy KW - Substance-Related Disorders -- metabolism KW - Phentermine -- therapeutic use KW - Phentermine -- adverse effects KW - Obesity -- drug therapy KW - Fenfluramine -- adverse effects KW - Obesity -- metabolism KW - Fenfluramine -- metabolism KW - Appetite Depressants -- adverse effects KW - Fenfluramine -- therapeutic use KW - Heart Valve Diseases -- chemically induced KW - Appetite Depressants -- metabolism KW - Appetite Depressants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67494287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+therapeutics&rft.atitle=Appetite+suppressants%2C+cardiac+valve+disease+and+combination+pharmacotherapy.&rft.au=Rothman%2C+Richard+B%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2009-07-01&rft.volume=16&rft.issue=4&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=American+journal+of+therapeutics&rft.issn=1536-3686&rft_id=info:doi/10.1097%2FMJT.0b013e31817fde95 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-21 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochim Biophys Acta. 1993 Oct 4;1144(3):249-63 [8104483] Pharmacol Rev. 1994 Jun;46(2):157-203 [7938165] J Exp Biol. 1994 Nov;196:229-36 [7823024] J Exp Biol. 1994 Nov;196:263-81 [7823027] Eur J Pharmacol. 1995 Aug 25;282(1-3):131-5 [7498267] J Heart Valve Dis. 1996 Mar;5(2):235-7 [8665020] J Consult Clin Psychol. 1997 Feb;65(1):79-85 [9103737] N Engl J Med. 1997 Aug 28;337(9):581-8 [9271479] N Engl J Med. 1997 Aug 28;337(9):629-30 [9271487] J Pharmacol Exp Ther. 1997 Nov;283(2):581-91 [9353373] Obes Res. 1997 Nov;5(6):578-86 [9449143] Pharmacol Biochem Behav. 1998 Mar;59(3):709-15 [9512076] Eur J Clin Pharmacol. 1998 Jan;53(5):347-9 [9516035] Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):87-96 [9716932] N Engl J Med. 1998 Sep 10;339(11):765-6 [9731094] Biochem Pharmacol. 1998 Aug 1;56(3):269-77 [9744561] Obes Res. 1999 Mar;7(2):189-98 [10102256] Diabetes Care. 1999 Jun;22(6):896-903 [10372238] Obes Res. 1999 Jul;7(4):313-22 [10440587] Pharmacol Rev. 1999 Sep;51(3):439-64 [10471414] Br J Pharmacol. 1999 Sep;128(1):13-20 [10498829] Obes Res. 2004 Dec;12 Suppl:163S-6S [15687412] Synapse. 2005 May;56(2):94-9 [15729739] Nat Neurosci. 2005 May;8(5):555-60 [15856062] J Am Diet Assoc. 2005 May;105(5 Suppl 1):S17-23 [15867891] J Pharmacol Exp Ther. 2005 Jun;313(3):1361-9 [15761112] J Am Diet Assoc. 2005 Jun;105(6):948-59 [15942547] Prog Neurobiol. 2005 Apr;75(6):406-33 [15955613] Physiology (Bethesda). 2005 Aug;20:225-31 [16024510] N Engl J Med. 2005 Nov 17;353(20):2111-20 [16291981] N Engl J Med. 2005 Nov 17;353(20):2121-34 [16291982] Expert Opin Investig Drugs. 2006 Mar;15(3):257-66 [16503763] Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):377-87 [16863450] MMWR Morb Mortal Wkly Rep. 2006 Sep 15;55(36):985-8 [16971886] Nature. 2006 Sep 21;443(7109):289-95 [16988703] Curr Top Med Chem. 2006;6(17):1845-59 [17017961] Cochrane Database Syst Rev. 2006;(4):CD006162 [17054276] Trends Pharmacol Sci. 2006 Dec;27(12):612-8 [17056126] N Engl J Med. 2007 Jan 4;356(1):6-9 [17202450] Drugs. 2007;67(1):27-55 [17209663] Gastroenterology. 2007 May;132(6):2087-102 [17498505] Gastroenterology. 2007 May;132(6):2239-52 [17498515] Psychol Health Med. 2007 May;12(3):321-7 [17510902] Annu Rev Clin Psychol. 2006;2:357-77 [17716074] Am J Cardiol. 2007 Nov 1;100(9):1442-5 [17950805] Vasc Health Risk Manag. 2007;3(5):665-71 [18078018] J Clin Hypertens (Greenwich). 2008 Jan;10(1 Suppl 1):4-12 [18174778] J Pharmacol Exp Ther. 2008 May;325(2):577-87 [18252809] Synapse. 2000 May;36(2):102-13 [10767057] Eur J Pharmacol. 2000 May 26;397(1):93-102 [10844103] Circulation. 2000 Dec 5;102(23):2836-41 [11104741] Neuropsychopharmacology. 2001 May;24(5):492-501 [11282249] Eur J Pharmacol. 2002 Jun 7;445(1-2):69-81 [12065196] Ann N Y Acad Sci. 2002 Jun;965:109-26 [12105089] Pharmacol Ther. 2002 Jul;95(1):73-88 [12163129] Am Heart J. 2002 Dec;144(6):1065-73 [12486432] J Pharmacol Exp Ther. 2003 Jun;305(3):1191-9 [12649307] Mol Pharmacol. 2003 Jun;63(6):1223-9 [12761331] Obes Res. 2003 Jun;11(6):722-33 [12805393] Eur J Pharmacol. 2003 Oct 31;479(1-3):229-36 [14612153] J Med Chem. 2004 May 6;47(10):2624-34 [15115403] Int J Obes Relat Metab Disord. 2004 Nov;28(11):1456-62 [15314631] Am Heart J. 1974 Nov;88(5):640-55 [4420941] Curr Probl Cardiol. 1999 Dec;24(12):745-92 [10609092] Mol Pharmacol. 2000 Jan;57(1):75-81 [10617681] Postgrad Med J. 1975;51 Suppl 1:80-3 [1241132] Drugs. 1976;11(5):378-93 [782835] Psychopharmacology (Berl). 1976 Nov 24;50(3):251-8 [826970] Eur J Clin Pharmacol. 1985;29(2):221-4 [4076322] Eur J Clin Pharmacol. 1986;30(1):75-7 [3709634] Appetite. 1986;7 Suppl:15-38 [2427023] J Pharmacol Exp Ther. 1987 Jun;241(3):817-25 [2885408] Nature. 1988 Sep 15;335(6187):254-6 [3045568] Psychopharmacology (Berl). 1988;95(3):364-8 [3137623] Clin Pharmacol Ther. 1992 May;51(5):642-6 [1587079] Xenobiotica. 1992 Nov;22(11):1251-66 [1492418] Annu Rev Neurosci. 1993;16:73-93 [8096377] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MJT.0b013e31817fde95 ER - TY - JOUR T1 - Therapeutic plasma exchange reveals a color-coordinated response to cyclosporine-induced microangiopathic hemolytic anemia and rifampin after stem cell transplant. AN - 67491805; 19602210 JF - Transfusion AU - Bryant, Barbara J AU - Leitman, Susan F AU - Klein, Harvey G AD - Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1184, USA. bryantb2@cc.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1291 EP - 1292 VL - 49 IS - 7 KW - Cyclosporine KW - 83HN0GTJ6D KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Humans KW - Adult KW - Female KW - Cyclosporine -- adverse effects KW - Anemia, Hemolytic -- chemically induced KW - Rifampin -- adverse effects KW - Plasma Exchange KW - Stem Cell Transplantation -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67491805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Therapeutic+plasma+exchange+reveals+a+color-coordinated+response+to+cyclosporine-induced+microangiopathic+hemolytic+anemia+and+rifampin+after+stem+cell+transplant.&rft.au=Bryant%2C+Barbara+J%3BLeitman%2C+Susan+F%3BKlein%2C+Harvey+G&rft.aulast=Bryant&rft.aufirst=Barbara&rft.date=2009-07-01&rft.volume=49&rft.issue=7&rft.spage=1291&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=1537-2995&rft_id=info:doi/10.1111%2Fj.1537-2995.2009.02155.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-31 N1 - Date created - 2009-07-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1537-2995.2009.02155.x ER - TY - JOUR T1 - Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition. AN - 67489605; 19584237 AB - Zalypsis (PM00104) is a novel tetrahydroisoquinoline alkaloid related to trabectedin [ecteinascidin 743 (Et743)]. Et743 and PM00104 have similar A and B rings but differ in their C rings. The present study shows that Et743 and PM00104 differ in at least two ways: in their DNA binding properties and nucleotide excision repair (NER) dependency for cellular targeting. DNase I footprinting shows that the two drugs bind DNA differentially. We also found that, in contrast to Et743, the antiproliferative activity of PM00104 does not depend on transcription-coupled NER. Accordingly, PM00104 induces gamma-H2AX foci with the same efficiency in NER-deficient or NER-proficient cells. Moreover, the formation of gamma-H2AX foci is replication dependent for PM00104, whereas it is both transcription and replication dependent in the case of Et743. These findings show the importance of the C ring structure of tetrahydroisoquinoline ecteinascidin derivatives for NER targeting. Finally, PM00104 exerts antiproliferative activity at nanomolar concentrations and induces gamma-H2AX response in two Ewing's sarcoma cell lines, suggesting that gamma-H2AX could serve as a pharmacodynamic biomarker for the clinical development of PM00104. JF - Molecular cancer therapeutics AU - Guirouilh-Barbat, Josée AU - Antony, Smitha AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 2007 EP - 2014 VL - 8 IS - 7 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Dioxoles KW - H2AFX protein, human KW - Histones KW - PM 00104 KW - Tetrahydroisoquinolines KW - trabectedin KW - ID0YZQ2TCP KW - Index Medicus KW - Sarcoma, Ewing -- pathology KW - Tumor Cells, Cultured KW - Humans KW - DNA Footprinting KW - Bone Neoplasms -- drug therapy KW - Bone Neoplasms -- pathology KW - Sarcoma, Ewing -- drug therapy KW - DNA Replication -- drug effects KW - Bone Neoplasms -- genetics KW - Sarcoma, Ewing -- genetics KW - Tetrahydroisoquinolines -- chemistry KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Histones -- metabolism KW - Tetrahydroisoquinolines -- pharmacology KW - Transcription, Genetic KW - Dioxoles -- chemistry KW - Dioxoles -- pharmacology KW - Histones -- genetics KW - DNA Repair -- drug effects KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67489605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Zalypsis+%28PM00104%29+is+a+potent+inducer+of+gamma-H2AX+foci+and+reveals+the+importance+of+the+C+ring+of+trabectedin+for+transcription-coupled+repair+inhibition.&rft.au=Guirouilh-Barbat%2C+Jos%C3%A9e%3BAntony%2C+Smitha%3BPommier%2C+Yves&rft.aulast=Guirouilh-Barbat&rft.aufirst=Jos%C3%A9e&rft.date=2009-07-01&rft.volume=8&rft.issue=7&rft.spage=2007&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=1538-8514&rft_id=info:doi/10.1158%2F1535-7163.MCT-09-0336 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-19 N1 - Date created - 2009-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1535-7163.MCT-09-0336 ER - TY - JOUR T1 - Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin. AN - 67489219; 19584235 AB - Brostallicin is a DNA minor groove binder in phase II clinical trials. Here, we show that brostallicin induces gamma-H2AX nuclear foci that colocalize with 53BP1 and are dependent on glutathione, as shown by inhibition of those gamma-H2AX foci by l-buthionine sulfoximine. To differentiate brostallicin from the clinically approved minor groove binder trabectedin (ecteinascidin 743), we tested whether the brostallicin-induced gamma-H2AX and antiproliferative responses were dependent on nucleotide excision repair and found that, unlike trabectedin, they are not. Additionally, brostallicin retained activity in the trabectedin-resistant HCT116-ER5 cell line. Induction of gamma-H2AX foci by brostallicin was partially dependent on the repair nuclease Mre11. Pretreatment with aphidicolin partially reduced brostallicin-induced gamma-H2AX foci, suggesting that brostallicin induces both replication-associated and replication-independent DNA damage. Replication-associated DNA damage was further shown by the colocalization of gamma-H2AX foci with replication foci and by the rapid inhibition of DNA synthesis and accumulation of cells in S phase in response to brostallicin. In addition, brostallicin was able to induce lower intensity gamma-H2AX foci in human circulating lymphocytes. Together, our results indicate that brostallicin induces DNA double-strand breaks and suggest gamma-H2AX as a pharmacodynamic biomarker for brostallicin. JF - Molecular cancer therapeutics AU - Guirouilh-Barbat, Josée AU - Zhang, Yong-Wei AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1985 EP - 1994 VL - 8 IS - 7 KW - Antineoplastic Agents KW - 0 KW - Antineoplastic Agents, Alkylating KW - Chromosomal Proteins, Non-Histone KW - DNA-Binding Proteins KW - Dioxoles KW - Guanidines KW - H2AFX protein, human KW - Histones KW - Intracellular Signaling Peptides and Proteins KW - MRE11A protein, human KW - Phosphoproteins KW - Pyrroles KW - Tetrahydroisoquinolines KW - Trp53bp1 protein, mouse KW - Tumor Suppressor p53-Binding Protein 1 KW - Glutathione KW - GAN16C9B8O KW - trabectedin KW - ID0YZQ2TCP KW - brostallicin KW - RPC6R41K4I KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Humans KW - Tetrahydroisoquinolines -- pharmacology KW - HCT116 Cells KW - Dioxoles -- pharmacology KW - Phosphoproteins -- pharmacology KW - DNA Replication -- drug effects KW - Blotting, Western KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Apoptosis -- drug effects KW - Cell Cycle -- drug effects KW - DNA-Binding Proteins -- metabolism KW - DNA Breaks, Double-Stranded -- drug effects KW - Histones -- metabolism KW - Glutathione -- metabolism KW - Pyrroles -- pharmacology KW - Antineoplastic Agents -- pharmacology KW - Guanidines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67489219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Induction+of+glutathione-dependent+DNA+double-strand+breaks+by+the+novel+anticancer+drug+brostallicin.&rft.au=Guirouilh-Barbat%2C+Jos%C3%A9e%3BZhang%2C+Yong-Wei%3BPommier%2C+Yves&rft.aulast=Guirouilh-Barbat&rft.aufirst=Jos%C3%A9e&rft.date=2009-07-01&rft.volume=8&rft.issue=7&rft.spage=1985&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=1538-8514&rft_id=info:doi/10.1158%2F1535-7163.MCT-09-0320 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-19 N1 - Date created - 2009-07-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Biol Cell. 2008 Sep;19(9):3969-81 [18632984] Expert Opin Pharmacother. 2008 Jun;9(9):1609-18 [18518789] Nat Rev Cancer. 2008 Dec;8(12):957-67 [19005492] J Biol Chem. 1996 Aug 16;271(33):19645-8 [8702663] Crit Rev Biochem Mol Biol. 1995;30(6):445-600 [8770536] Br J Cancer. 1997;75(6):878-83 [9062410] Chem Biol Interact. 1998 Apr 24;111-112:377-88 [9679568] Anticancer Drugs. 1998 Oct;9(9):779-82 [9840723] Cancer Res. 2005 Jun 15;65(12):5337-43 [15958581] Mol Cancer Ther. 2005 Aug;4(8):1175-85 [16093433] Oncogene. 2006 Mar 13;25(11):1639-48 [16550164] Curr Opin Oncol. 2006 Jul;18(4):347-53 [16721129] Cancer Res. 2002 Apr 15;62(8):2332-6 [11956092] Mol Cell Biol. 2000 Jun;20(11):3977-87 [10805740] Nat Cell Biol. 2000 Oct;2(10):686-94 [11025658] J Cell Biol. 2000 Dec 25;151(7):1381-90 [11134068] Eur J Cancer. 2001 Jan;37(1):97-105 [11165136] Nat Med. 2001 Aug;7(8):961-6 [11479630] Chem Biol. 2001 Nov;8(11):1033-49 [11731295] Expert Opin Investig Drugs. 2001 Sep;10(9):1703-14 [11772279] Anticancer Drugs. 2002 Jul;13(6):545-55 [12172500] Farmaco. 2003 Mar;58(3):213-20 [12620417] J Biol Chem. 2003 May 30;278(22):20303-12 [12660252] Br J Cancer. 2003 Oct 20;89(8):1559-65 [14562032] Oncogene. 2004 Apr 8;23(15):2640-7 [15048091] Anticancer Drugs. 2004 Jan;15(1):1-6 [15090736] Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1229-33 [6469743] Cancer Res. 1989 Mar 15;49(6):1422-8 [2466554] Crit Rev Biochem Mol Biol. 1992;27(4-5):337-84 [1521461] Tohoku J Exp Med. 1992 Oct;168(2):97-103 [1306337] Nucleic Acids Res. 1993 Aug 25;21(17):3997-4004 [8371975] Cancer Res. 1995 Jun 1;55(11):2304-9 [7757980] Cancer Res. 2006 Jul 15;66(14):7203-10 [16849567] J Biol Chem. 2006 Oct 13;281(41):30814-23 [16905549] Eur J Cancer. 2007 Jan;43(2):308-15 [17095209] Anticancer Drugs. 2007 Mar;18(3):245-54 [17264755] DNA Repair (Amst). 2007 Jul 1;6(7):953-66 [17531546] Mol Cancer Res. 2007 Jul;5(7):713-24 [17634426] Mol Cell Biol. 2007 Aug;27(16):5806-18 [17515603] Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13062-7 [17656556] Curr Opin Pharmacol. 2007 Aug;7(4):360-6 [17613273] Mol Cancer Ther. 2007 Oct;6(10):2708-18 [17938264] Cancer Res. 2007 Nov 1;67(21):10397-405 [17974983] Cell Cycle. 2007 Nov 15;6(22):2760-7 [17986860] Cell. 2008 Oct 3;135(1):97-109 [18854158] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1535-7163.MCT-09-0320 ER - TY - JOUR T1 - Continuous-infusion beta-lactam antibiotics during continuous venovenous hemofiltration for the treatment of resistant gram-negative bacteria. AN - 67489214; 19584386 AB - To describe the rationale, principles, and dosage calculations for continuous-infusion beta-lactam antibiotics to treat multidrug-resistant bacteria in patients undergoing continuous venovenous hemofiltration (CVVH). A MEDLINE search (1968-November 2008) of the English-language literature was performed using the terms continuous infusion and Pseudomonas or Acinetobacter; hemofiltration or CVVH or hemodiafiltration or CVVHDF or continuous renal replacement therapy or pharmacokinetics; and terms describing different beta-lactam antibiotics. In vitro, in vivo, and human studies were evaluated that used continuous-infusion beta-lactam antibiotics to treat Pseudomonas aeruginosa and Acinetobacter baumannii infections. Studies were reviewed that described the pharmacokinetics of beta-lactam antibiotics during CVVH as well as other modalities of continuous renal replacement therapy. Continuous infusion of beta-lactam antibiotics, maintaining drug concentrations 4-5 times higher than the minimum inhibitory concentration, is a promising approach for managing infections caused by P. aeruginosa and A. baumannii. Safe yet effective continuous infusion therapy is made difficult by the occurrence of acute renal failure and the need for renal replacement therapy. Case series and pharmacokinetic properties indicate that several beta-lactam antimicrobials that have been studied for continuous infusion, such as cefepime, ceftazidime, piperacillin, ticarcillin, clavulanic acid, and tazobactam, are significantly cleared by hemofiltration. Methodology and formulas are provided that allow practitioners to calculate dosage regimens and reach target drug concentrations for continuous beta-lactam antibiotic infusions during CVVH based on a literature review, pharmacokinetic principles, and our experience at the National Institutes of Health Clinical Center. Continuous infusion of beta-lactam antibiotics may be a useful treatment strategy for multidrug-resistant gram-negative infections in the intensive care unit. Well-established pharmacokinetic and pharmacodynamic principles can be used to safely reach and maintain steady-state target concentrations of beta-lactam antibiotics in critical illness complicated by acute renal failure requiring CVVH. JF - The Annals of pharmacotherapy AU - Moriyama, Brad AU - Henning, Stacey A AU - Neuhauser, Melinda M AU - Danner, Robert L AU - Walsh, Thomas J AD - Pharmacy Department, National Institutes of Health Clinical Center, Bethesda, MD, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1324 EP - 1337 VL - 43 IS - 7 KW - Anti-Bacterial Agents KW - 0 KW - beta-Lactams KW - Index Medicus KW - Animals KW - Infusions, Intravenous KW - Humans KW - Clinical Trials as Topic KW - Drug Resistance, Multiple, Bacterial KW - Microbial Sensitivity Tests KW - Gram-Negative Bacteria -- drug effects KW - beta-Lactams -- adverse effects KW - beta-Lactams -- administration & dosage KW - beta-Lactams -- pharmacokinetics KW - Anti-Bacterial Agents -- adverse effects KW - Hemofiltration KW - Gram-Negative Bacterial Infections -- drug therapy KW - Gram-Negative Bacterial Infections -- microbiology KW - Anti-Bacterial Agents -- administration & dosage KW - Anti-Bacterial Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67489214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Continuous-infusion+beta-lactam+antibiotics+during+continuous+venovenous+hemofiltration+for+the+treatment+of+resistant+gram-negative+bacteria.&rft.au=Moriyama%2C+Brad%3BHenning%2C+Stacey+A%3BNeuhauser%2C+Melinda+M%3BDanner%2C+Robert+L%3BWalsh%2C+Thomas+J&rft.aulast=Moriyama&rft.aufirst=Brad&rft.date=2009-07-01&rft.volume=43&rft.issue=7&rft.spage=1324&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=1542-6270&rft_id=info:doi/10.1345%2Faph.1L638 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-24 N1 - Date created - 2009-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1345/aph.1L638 ER - TY - JOUR T1 - In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene. AN - 67463166; 19509470 AB - Major limitations to gene therapy using HSCs are low gene transfer efficiency and the inability of most therapeutic genes to confer a selective advantage on the gene-corrected cells. One approach to enrich for gene-modified cells in vivo is to include in the retroviral vector a drug resistance gene, such as the P140K mutant of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT*). We transplanted 5 rhesus macaques with CD34+ cells transduced with lentiviral vectors encoding MGMT* and a fluorescent marker, with or without homeobox B4 (HOXB4), a potent stem cell self-renewal gene. Transgene expression and common integration sites in lymphoid and myeloid lineages several months after transplantation confirmed transduction of long-term repopulating HSCs. However, all animals showed only a transient increase in gene-marked lymphoid and myeloid cells after O6-benzylguanine (BG) and temozolomide (TMZ) administration. In 1 animal, cells transduced with MGMT* lentiviral vectors were protected and expanded after multiple courses of BG/TMZ, providing a substantial increase in the maximum tolerated dose of TMZ. Additional cycles of chemotherapy using 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) resulted in similar increases in gene marking levels, but caused high levels of nonhematopoietic toxicity. Inclusion of HOXB4 in the MGMT* vectors resulted in no substantial increase in gene marking or HSC amplification after chemotherapy treatment. Our data therefore suggest that lentivirally mediated gene transfer in transplanted HSCs can provide in vivo chemoprotection of progenitor cells, although selection of long-term repopulating HSCs was not seen. JF - The Journal of clinical investigation AU - Larochelle, Andre AU - Choi, Uimook AU - Shou, Yan AU - Naumann, Nora AU - Loktionova, Natalia A AU - Clevenger, Joshua R AU - Krouse, Allen AU - Metzger, Mark AU - Donahue, Robert E AU - Kang, Elizabeth AU - Stewart, Clinton AU - Persons, Derek AU - Malech, Harry L AU - Dunbar, Cynthia E AU - Sorrentino, Brian P AD - National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. larochea@nhlbi.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1952 EP - 1963 VL - 119 IS - 7 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Homeodomain Proteins KW - O(6)-benzylguanine KW - 01KC87F8FE KW - Guanine KW - 5Z93L87A1R KW - Dacarbazine KW - 7GR28W0FJI KW - O(6)-Methylguanine-DNA Methyltransferase KW - EC 2.1.1.63 KW - Carmustine KW - U68WG3173Y KW - temozolomide KW - YF1K15M17Y KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Genetic Vectors KW - Homeodomain Proteins -- physiology KW - Hematopoietic Stem Cell Transplantation KW - Macaca mulatta KW - Guanine -- analogs & derivatives KW - Carmustine -- pharmacology KW - Guanine -- pharmacology KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Dacarbazine -- analogs & derivatives KW - Dacarbazine -- pharmacology KW - Lentivirus -- genetics KW - Genetic Therapy KW - O(6)-Methylguanine-DNA Methyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67463166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=In+vivo+selection+of+hematopoietic+progenitor+cells+and+temozolomide+dose+intensification+in+rhesus+macaques+through+lentiviral+transduction+with+a+drug+resistance+gene.&rft.au=Larochelle%2C+Andre%3BChoi%2C+Uimook%3BShou%2C+Yan%3BNaumann%2C+Nora%3BLoktionova%2C+Natalia+A%3BClevenger%2C+Joshua+R%3BKrouse%2C+Allen%3BMetzger%2C+Mark%3BDonahue%2C+Robert+E%3BKang%2C+Elizabeth%3BStewart%2C+Clinton%3BPersons%2C+Derek%3BMalech%2C+Harry+L%3BDunbar%2C+Cynthia+E%3BSorrentino%2C+Brian+P&rft.aulast=Larochelle&rft.aufirst=Andre&rft.date=2009-07-01&rft.volume=119&rft.issue=7&rft.spage=1952&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=1558-8238&rft_id=info:doi/10.1172%2FJCI37506 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-30 N1 - Date created - 2009-07-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 1995 Aug;16(8):1687-92 [7634390] Genes Dev. 1995 Jul 15;9(14):1753-65 [7622039] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11871-6 [8876230] Mol Cell Biol. 1997 Jan;17(1):495-505 [8972230] J Virol. 1997 Dec;71(12):9466-74 [9371608] Nat Med. 1998 Oct;4(10):1136-43 [9771746] Blood. 1999 May 1;93(9):2839-48 [10216078] Biochem Pharmacol. 1999 Jul 15;58(2):237-44 [10423163] PLoS Biol. 2004 Dec;2(12):e423 [15550989] Blood. 2005 Feb 1;105(3):997-1002 [15494421] N Engl J Med. 2005 Mar 10;352(10):987-96 [15758009] J Clin Oncol. 2005 Oct 1;23(28):7178-87 [16192602] Nat Rev Microbiol. 2005 Nov;3(11):848-58 [16175173] Trends Biotechnol. 2005 Dec;23(12):589-97 [16216357] Blood. 2006 Mar 1;107(5):1751-60 [16269617] Blood. 2006 May 1;107(9):3772-8 [16439684] PLoS Med. 2006 May;3(5):e173 [16637742] Mol Ther. 2006 Jun;13(6):1031-49 [16624621] Nat Genet. 2006 Nov;38(11):1323-8 [17013394] Hum Gene Ther. 2007 May;18(5):451-6 [17536975] Mol Ther. 2007 Sep;15(9):1630-9 [17609656] Blood. 2007 Sep 15;110(6):1806-13 [17526860] Methods Mol Biol. 2007;395:17-34 [17993665] J Clin Invest. 2008 Apr;118(4):1502-10 [18357342] Blood. 2008 May 1;111(9):4431-44 [18441245] Cancer Res. 2008 Aug 1;68(15):6171-80 [18676840] Blood. 1999 Nov 15;94(10):3349-57 [10552944] Science. 2000 Apr 28;288(5466):669-72 [10784449] Blood. 2000 May 15;95(10):3078-84 [10807772] Cancer Res. 2000 Sep 15;60(18):5187-95 [11016647] Blood. 2000 Nov 15;96(10):3399-405 [11071634] Mol Ther. 2001 Jan;3(1):78-87 [11162314] Nat Med. 2001 Sep;7(9):1028-34 [11533706] Stem Cells. 2002;20(1):11-20 [11796918] Science. 2002 Feb 1;295(5556):868-72 [11786607] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3123-8 [11867757] Genome Res. 2002 Apr;12(4):656-64 [11932250] Cell. 2002 Apr 5;109(1):39-45 [11955445] Hum Gene Ther. 2002 Nov 20;13(17):2007-16 [12489996] Mol Ther. 2003 Apr;7(4):438-40 [12727105] Blood. 2003 Jul 15;102(2):506-13 [12663444] Mol Ther. 2003 Sep;8(3):376-84 [12946310] Cancer Chemother Pharmacol. 2003 Dec;52(6):435-41 [13680158] J Clin Invest. 2003 Nov;112(10):1561-70 [14617757] J Clin Invest. 2003 Nov;112(10):1581-8 [14617759] Hum Gene Ther. 2003 Dec 10;14(18):1703-14 [14670122] Blood. 2004 Feb 1;103(3):796-803 [12920024] Nat Rev Cancer. 2004 Mar;4(3):177-83 [14993899] Nat Biotechnol. 2004 May;22(5):589-94 [15064769] Blood. 2004 Jun 1;103(11):4062-9 [14976042] Exp Hematol. 2004 Aug;32(8):709-19 [15308322] PLoS Biol. 2004 Aug;2(8):E234 [15314653] Mol Ther. 2004 Sep;10(3):417-31 [15336643] Blood. 2004 Sep 15;104(6):1648-55 [15178579] Blood. 2009 May 28;113(22):5434-43 [19339698] Curr Stem Cell Res Ther. 2008 Dec;3(4):237-46 [19075754] Blood. 2004 Oct 15;104(8):2281-90 [15198957] Anal Biochem. 1976 May 7;72:248-54 [942051] Science. 1992 Jul 3;257(5066):99-103 [1352414] Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9676-80 [1357667] EMBO J. 1993 Oct;12(10):3835-46 [8104786] J Virol. 1995 Feb;69(2):748-55 [7815539] Blood. 1996 Feb 15;87(4):1644-53 [8608259] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1172/JCI37506 ER - TY - JOUR T1 - Evaluation of nanoparticle immunotoxicity. AN - 67460617; 19581891 AB - The pharmaceutical industry is developing increasing numbers of drugs and diagnostics based on nanoparticles, and evaluating the immune response to these diverse formulations has become a challenge for scientists and regulatory agencies alike. An international panel of scientists and representatives from various agencies and companies reviewed the imitations of current tests at a workshop held at the National Cancer Institute in Frederick, Maryland. This article outlines practical strategies for identifying and controlling interferences in common evaluation methods and the implications for regulation. JF - Nature nanotechnology AU - Dobrovolskaia, Marina A AU - Germolec, Dori R AU - Weaver, James L AD - Nanotechnology Characterization Laboratory, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland 21702, USA. marina@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 411 EP - 414 VL - 4 IS - 7 KW - Immunotoxins KW - 0 KW - Index Medicus KW - Drug Industry -- standards KW - Clinical Laboratory Techniques -- standards KW - Immunotoxins -- toxicity KW - Limulus Test KW - Toxicity Tests -- methods KW - Nanoparticles -- toxicity KW - Toxicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67460617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+nanotechnology&rft.atitle=Evaluation+of+nanoparticle+immunotoxicity.&rft.au=Dobrovolskaia%2C+Marina+A%3BGermolec%2C+Dori+R%3BWeaver%2C+James+L&rft.aulast=Dobrovolskaia&rft.aufirst=Marina&rft.date=2009-07-01&rft.volume=4&rft.issue=7&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Nature+nanotechnology&rft.issn=1748-3395&rft_id=info:doi/10.1038%2Fnnano.2009.175 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-25 N1 - Date created - 2009-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nnano.2009.175 ER - TY - JOUR T1 - Analytical and statistical approaches to metabolomics research. AN - 67450273; 19569098 AB - Metabolomics, the global profiling of metabolites in different living systems, has experienced a rekindling of interest partially due to the improved detection capabilities of the instrumental techniques currently being used in this area of biomedical research. The analytical methods of choice for the analysis of metabolites in search of disease biomarkers in biological specimens, and for the study of various low molecular weight metabolic pathways include NMR spectroscopy, GC/MS, CE/MS, and HPLC/MS. Global metabolite analysis and profiling of two different sets of data results in a plethora of data that is difficult to manage or interpret manually because of their subtle differences. Multivariate statistical methods and pattern-recognition programs were developed to handle the acquired data and to search for the discriminating features between data acquired from two sample sets, healthy and diseased. Metabolomics have been used in toxicology, plant physiology, and biomedical research. In this paper, we discuss various aspects of metabolomic research including sample collection, handling, storage, requirements for sample analysis, peak alignment, data interpretation using statistical approaches, metabolite identification, and finally recommendations for successful analysis. JF - Journal of separation science AU - Issaq, Haleem J AU - Van, Que N AU - Waybright, Timothy J AU - Muschik, Gary M AU - Veenstra, Timothy D AD - Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD, USA. issaqh@mail.ncifcrf.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 2183 EP - 2199 VL - 32 IS - 13 KW - Biomarkers KW - 0 KW - Index Medicus KW - Software KW - Chromatography, High Pressure Liquid -- instrumentation KW - Gas Chromatography-Mass Spectrometry -- methods KW - Nuclear Magnetic Resonance, Biomolecular -- methods KW - Gas Chromatography-Mass Spectrometry -- instrumentation KW - Humans KW - Chromatography, High Pressure Liquid -- methods KW - Nuclear Magnetic Resonance, Biomolecular -- instrumentation KW - Specimen Handling -- methods KW - Electrophoresis, Capillary -- methods KW - Electrophoresis, Capillary -- instrumentation KW - Biomedical Research -- methods KW - Biomarkers -- analysis KW - Metabolomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67450273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+separation+science&rft.atitle=Analytical+and+statistical+approaches+to+metabolomics+research.&rft.au=Issaq%2C+Haleem+J%3BVan%2C+Que+N%3BWaybright%2C+Timothy+J%3BMuschik%2C+Gary+M%3BVeenstra%2C+Timothy+D&rft.aulast=Issaq&rft.aufirst=Haleem&rft.date=2009-07-01&rft.volume=32&rft.issue=13&rft.spage=2183&rft.isbn=&rft.btitle=&rft.title=Journal+of+separation+science&rft.issn=1615-9314&rft_id=info:doi/10.1002%2Fjssc.200900152 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-14 N1 - Date created - 2009-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jssc.200900152 ER - TY - JOUR T1 - Sexual Acquisition and Transmission of HIV Cooperative Agreement Program (SATHCAP), July 2009: introduction. AN - 67449593; 19543977 JF - Journal of urban health : bulletin of the New York Academy of Medicine AU - Compton, Wilson AU - Normand, Jacques AU - Lambert, Elizabeth AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, 6001 Executive Blvd., Bethesda, MD 20892, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1 EP - 4 VL - 86 Suppl 1 KW - Index Medicus KW - United States KW - Humans KW - National Institute on Drug Abuse (U.S.) KW - Substance-Related Disorders KW - Male KW - Female KW - Cooperative Behavior KW - HIV Infections -- transmission KW - HIV Infections -- prevention & control KW - Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67449593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+urban+health+%3A+bulletin+of+the+New+York+Academy+of+Medicine&rft.atitle=Sexual+Acquisition+and+Transmission+of+HIV+Cooperative+Agreement+Program+%28SATHCAP%29%2C+July+2009%3A+introduction.&rft.au=Compton%2C+Wilson%3BNormand%2C+Jacques%3BLambert%2C+Elizabeth&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2009-07-01&rft.volume=86+Suppl+1&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+urban+health+%3A+bulletin+of+the+New+York+Academy+of+Medicine&rft.issn=1468-2869&rft_id=info:doi/10.1007%2Fs11524-009-9373-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-13 N1 - Date created - 2009-07-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: AIDS. 2000 Sep 29;14(14):2191-200 [11061661] Lancet. 2001 May 5;357(9266):1397-401 [11356437] JAMA. 2008 Aug 6;300(5):520-9 [18677024] J Urban Health. 2003 Dec;80(4 Suppl 3):iii7-14 [14713667] J Urban Health. 2003 Dec;80(4 Suppl 3):iii1-6 [14713666] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11524-009-9373-4 ER - TY - JOUR T1 - IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding. AN - 67435776; 19395593 AB - A new web-server tool estimates K(i) values from experimentally determined IC(50) values for inhibitors of enzymes and of binding reactions between macromolecules (e.g. proteins, polynucleic acids) and ligands. This converter was developed to enable end users to help gauge the quality of the underlying assumptions used in these calculations which depend on the type of mechanism of inhibitor action and the concentrations of the interacting molecular species. Additional calculations are performed for nonclassical, tightly bound inhibitors of enzyme-substrate or of macromolecule-ligand systems in which free, rather than total concentrations of the reacting species are required. Required user-defined input values include the total enzyme (or another target molecule) and substrate (or ligand) concentrations, the K(m) of the enzyme-substrate (or the K(d) of the target-ligand) reaction, and the IC(50) value. Assumptions and caveats for these calculations are discussed along with examples taken from the literature. The host database for this converter contains kinetic constants and other data for inhibitors of the proteolytic clostridial neurotoxins (http://botdb.abcc.ncifcrf.gov/toxin/kiConverter.jsp). JF - Nucleic acids research AU - Cer, R Z AU - Mudunuri, U AU - Stephens, R AU - Lebeda, F J AD - Advanced Biomedical Computing Center, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - W441 EP - W445 VL - 37 KW - Enzyme Inhibitors KW - 0 KW - Enzymes KW - Ligands KW - Index Medicus KW - Enzymes -- chemistry KW - Kinetics KW - Enzymes -- metabolism KW - User-Computer Interface KW - Inhibitory Concentration 50 KW - Internet KW - Software KW - Enzyme Inhibitors -- chemistry KW - Enzyme Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67435776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=IC50-to-Ki%3A+a+web-based+tool+for+converting+IC50+to+Ki+values+for+inhibitors+of+enzyme+activity+and+ligand+binding.&rft.au=Cer%2C+R+Z%3BMudunuri%2C+U%3BStephens%2C+R%3BLebeda%2C+F+J&rft.aulast=Cer&rft.aufirst=R&rft.date=2009-07-01&rft.volume=37&rft.issue=&rft.spage=W441&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkp253 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-16 N1 - Date created - 2009-06-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Toxicol Methods. 2001 Sep-Oct;46(2):61-71 [12481843] Br J Pharmacol. 1993 Aug;109(4):1110-9 [8401922] Anal Biochem. 2004 Sep 15;332(2):261-73 [15325294] Biochem J. 1972 Apr;127(2):321-33 [4263188] Biochem Pharmacol. 1973 Dec 1;22(23):3099-108 [4202581] Drug Metab Dispos. 2006 Apr;34(4):534-8 [16415122] Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W748-52 [16845112] Nucleic Acids Res. 2007 Jan;35(Database issue):D511-4 [17202167] J Med Chem. 2007 May 3;50(9):2127-36 [17417831] Infect Immun. 2007 Jul;75(7):3212-9 [17420237] J Pharmacokinet Pharmacodyn. 2008 Jun;35(3):251-67 [18551355] Nucleic Acids Res. 2009 Jan;37(Database issue):D365-8 [19010965] J Neurochem. 1983 Feb;40(2):510-3 [6822834] Biochem Med Metab Biol. 1987 Jun;37(3):344-9 [3606895] J Recept Res. 1988;8(1-4):533-46 [3385692] Trends Pharmacol Sci. 1993 Mar;14(3):89-91 [8488569] J Biomol Screen. 2003 Feb;8(1):34-8 [12854996] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkp253 ER - TY - JOUR T1 - Regulation and function of proline oxidase under nutrient stress. AN - 67430837; 19415679 AB - Under conditions of nutrient stress, cells switch to a survival mode catabolizing cellular and tissue constituents for energy. Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (POX), a mitochondrial inner membrane enzyme, can generate ATP. This degradative pathway generates glutamate and alpha-ketoglutarate, products that can play an anaplerotic role for the TCA cycle. In addition the proline cycle is in a metabolic interlock with the pentose phosphate pathway providing another bioenergetic mechanism. Herein we have investigated the role of proline metabolism in conditions of nutrient stress in the RKO colorectal cancer cell line. The induction of stress either by glucose withdrawal or by treatment with rapamycin, stimulated degradation of proline and increased POX catalytic activity. Under these conditions POX was responsible, at least in part, for maintenance of ATP levels. Activation of AMP-activated protein kinase (AMPK), the cellular energy sensor, by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), also markedly upregulated POX and increased POX-dependent ATP levels, further supporting its role during stress. Glucose deprivation increased intracellular proline levels, and expression of POX activated the pentose phosphate pathway. Together, these results suggest that the induction of proline cycle under conditions of nutrient stress may be a mechanism by which cells switch to a catabolic mode for maintaining cellular energy levels. 2009 Wiley-Liss, Inc. JF - Journal of cellular biochemistry AU - Pandhare, Jui AU - Donald, Steven P AU - Cooper, Sandra K AU - Phang, James M AD - Metabolism & Cancer Susceptibility Section, Laboratory of Comparative, Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA. Y1 - 2009/07/01/ PY - 2009 DA - 2009 Jul 01 SP - 759 EP - 768 VL - 107 IS - 4 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Proline KW - 9DLQ4CIU6V KW - Proline Oxidase KW - EC 1.5.3.- KW - Glucose KW - IY9XDZ35W2 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Proline -- metabolism KW - Colorectal Neoplasms -- pathology KW - Colorectal Neoplasms -- metabolism KW - Humans KW - Sirolimus -- pharmacology KW - Adenosine Triphosphate -- metabolism KW - Cell Line, Tumor KW - Up-Regulation KW - Glucose -- deficiency KW - Stress, Physiological KW - Proline Oxidase -- metabolism KW - Malnutrition -- enzymology KW - Proline Oxidase -- physiology KW - Proline Oxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67430837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+to+Mouse+Allergen+in+U.S.+Homes+Associated+with+Asthma+Symptoms&rft.au=Salo%2C+P+M%3BJaramillo%2C+R%3BCohn%2C+R+D%3BLondon%2C+S+J%3BZeldin%2C+D+C&rft.aulast=Salo&rft.aufirst=P&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11847 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-26 N1 - Date created - 2009-06-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1989 Jun 5;264(16):9352-8 [2722838] J Biol Chem. 1988 Sep 15;263(26):13083-9 [2458343] Trends Biochem Sci. 1999 Feb;24(2):68-72 [10098401] Nat Rev Mol Cell Biol. 2005 Jun;6(6):439-48 [15928708] Oncogene. 2005 Jun 16;24(26):4165-73 [15806154] Carcinogenesis. 2005 Aug;26(8):1335-42 [15817612] Nat Rev Immunol. 2005 Nov;5(11):844-52 [16239903] Exp Biol Med (Maywood). 2006 Jan;231(1):20-7 [16380641] J Biol Chem. 2006 Jan 27;281(4):2044-52 [16303758] Appl Environ Microbiol. 2006 Jun;72(6):4001-6 [16751508] Prostate Cancer Prostatic Dis. 2006;9(3):230-4 [16683009] J Biol Chem. 2006 Nov 3;281(44):33045-52 [16914544] Sci STKE. 2007 Apr 10;2007(381):pe14 [17426345] J Biol Chem. 2007 May 11;282(19):14316-27 [17344208] Mol Cell. 2008 Apr 25;30(2):214-26 [18439900] Oncogene. 2008 Dec 4;27(53):6729-37 [18794809] Cancer Res. 2001 Mar 1;61(5):1810-5 [11280728] Nat Cell Biol. 2001 Nov;3(11):E255-63 [11715037] Biochem Biophys Res Commun. 2002 Jan 11;290(1):263-7 [11779163] Oncogene. 2002 Sep 5;21(39):6082-90 [12203120] FASEB J. 2002 Oct;16(12):1550-7 [12374777] Eur J Biochem. 2003 Mar;270(5):781-90 [12603311] Am J Pathol. 2003 Oct;163(4):1233-43 [14507633] Endocrinology. 2003 Dec;144(12):5179-83 [12960015] Trends Biochem Sci. 2004 Nov;29(11):586-92 [15501677] Arch Biochem Biophys. 1983 Aug;225(1):95-101 [6688511] Curr Top Cell Regul. 1985;25:91-132 [2410198] Arch Biochem Biophys. 1986 Jul;248(1):166-74 [3729412] Nature. 1997 Sep 18;389(6648):300-5 [9305847] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jcb.22174 ER - TY - JOUR T1 - Corneal verticillata after dual anti-epidermal growth factor receptor and anti-vascular endothelial growth factor receptor 2 therapy (vandetanib) for anaplastic astrocytoma. AN - 67414234; 19512898 AB - To describe a patient with a history of epithelial basement membrane dystrophy who developed symptomatic corneal verticillata after vandetanib therapy for anaplastic astrocytoma. Retrospective interventional case report. A 48-year-old female patient with a history of anaplastic astrocytoma status post resection, external beam radiation, and chemotherapy presented with glare symptoms, decreased contrast sensitivity, and increased lacrimation after approximately 12 months of therapy with the anti-epidermal growth factor receptor (EGFR) and anti-vascular endothelial growth factor receptor 2 protein tyrosine kinase inhibitor, vandetanib. Ophthalmic examination revealed diffuse corneal verticillata and fine subepithelial opacities. Schirmer 1 testing was normal bilaterally. Therapy with carboxymethylcellulose, 5% sodium chloride ointment, and a decrease in the dose of vandetanib led to an improvement in the patient's ophthalmic symptoms despite persistence of the corneal findings. The patient remained under surveillance for tumor recurrence. Vandetanib (ZD6474), a protein tyrosine kinase inhibitor with dual anti-EGFR and anti-vascular endothelial growth factor receptor 2 action, may have contributed to the formation of corneal verticillata in our patient. Inhibition of EGFR, which is involved with corneal epithelial cell migration and wound healing, may play a role in the pathogenesis underlying corneal vortex keratopathy and ocular surface conditions with significant epithelial turnover. JF - Cornea AU - Yeh, Steven AU - Fine, Howard A AU - Smith, Janine A AD - National Eye Institute and daggerNational Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 699 EP - 702 VL - 28 IS - 6 KW - Ointments KW - 0 KW - Piperidines KW - Quinazolines KW - Sodium Chloride KW - 451W47IQ8X KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Vascular Endothelial Growth Factor Receptor-2 KW - Cellulase KW - EC 3.2.1.4 KW - carboxymethylcellulase KW - N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine KW - YO460OQ37K KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Humans KW - Retrospective Studies KW - Middle Aged KW - Cellulase -- therapeutic use KW - Sodium Chloride -- therapeutic use KW - Female KW - Corneal Opacity -- chemically induced KW - Corneal Diseases -- chemically induced KW - Astrocytoma -- surgery KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Astrocytoma -- drug therapy KW - Piperidines -- adverse effects KW - Quinazolines -- administration & dosage KW - Brain Neoplasms -- drug therapy KW - Neoplasm Recurrence, Local -- drug therapy KW - Brain Neoplasms -- surgery KW - Piperidines -- administration & dosage KW - Vascular Endothelial Growth Factor Receptor-2 -- antagonists & inhibitors KW - Corneal Diseases -- pathology KW - Quinazolines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67414234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cornea&rft.atitle=Corneal+verticillata+after+dual+anti-epidermal+growth+factor+receptor+and+anti-vascular+endothelial+growth+factor+receptor+2+therapy+%28vandetanib%29+for+anaplastic+astrocytoma.&rft.au=Yeh%2C+Steven%3BFine%2C+Howard+A%3BSmith%2C+Janine+A&rft.aulast=Yeh&rft.aufirst=Steven&rft.date=2009-07-01&rft.volume=28&rft.issue=6&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Cornea&rft.issn=1536-4798&rft_id=info:doi/10.1097%2FICO.0b013e3181922146 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-08 N1 - Date created - 2009-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/ICO.0b013e3181922146 ER - TY - JOUR T1 - Consumer awareness and attitudes related to new potential reduced-exposure tobacco product brands. AN - 67411957; 19541949 AB - In recent years, there has been a proliferation of potential reduced-exposure tobacco products (PREPs) marketed that claim to be less harmful or less addictive, compared with conventional cigarettes. Tobacco control scientists have raised concerns about the potential adverse impact of marketing of these products for smoking prevention and cessation efforts. Although these products have not been widely used among smokers, there are few data available on consumers' awareness and attitudes toward these products. Data were obtained from the 2003 and 2005 Health Information National Trends Survey, a nationally representative telephone survey of adults 18 years and older regarding health communication and associated beliefs and behaviors. Our study population consisted of 6,369 respondents in 2003 and 5,586 respondents in 2005, of whom 19% were current smokers and 28% were former smokers. In 2005, 45% of respondents had heard of at least one PREP product, while only 4.8% had actually tried one. Awareness and use were substantially higher among current smokers (55.6% and 12.7%). Awareness was highest for Marlboro Ultra Smooth (MUS) (30.2%), Eclipse (18.2%), Quest (7.8%), and Ariva (5.4%), while less than 2% for any other product. Of respondents who had tried a PREP, 50% cited harm reduction or assistance in quitting as a reason for trying the product and 30% believed that the product was less harmful than their usual brand. In the combined 2003 and 2005 dataset, 54.4% of current smokers stated that they would be "very" or "somewhat" interested in trying a cigarette advertised as less harmful, while only 3.2% of former smokers and 1.1% of never-smokers were interested. Among current smokers, interest was higher in females and non-Hispanic Whites, and among daily smokers, those who smoked 20 or more cigarettes per day and those who were not considering quitting. Smokers interested in PREPs were substantially more likely to rate their perceived lung cancer risk as high (40.3% vs. 8.3%) and to worry frequently about developing lung cancer (19.7% vs. 4%). These results suggest that there is a substantial level of interest among current smokers in cigarettes marketed with claims of reduced exposure or harm. Of particular concern is that "health conscious" smokers and heavy smokers not planning to quit may be especially vulnerable to PREP marketing messages and view such products as an alternative to smoking cessation. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Parascandola, Mark AU - Augustson, Erik AU - O'Connell, Mary E AU - Marcus, Stephen AD - Division of Cancer Control and Population Sciences, Tobacco Control Research Branch, National Cancer Institute, 6130 Executive Boulevard, Room 4039, Bethesda, MD 20892-7337, USA. paramark@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 886 EP - 895 VL - 11 IS - 7 KW - Index Medicus KW - Socioeconomic Factors KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Sex Distribution KW - Health Education -- organization & administration KW - Male KW - Female KW - Ethnic Groups -- statistics & numerical data KW - Advertising as Topic -- statistics & numerical data KW - Tobacco Use Disorder -- epidemiology KW - Smoking Cessation -- methods KW - Health Knowledge, Attitudes, Practice KW - Tobacco Use Disorder -- prevention & control KW - Smoking -- prevention & control KW - Smoking -- epidemiology KW - Consumer Behavior -- statistics & numerical data KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67411957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Consumer+awareness+and+attitudes+related+to+new+potential+reduced-exposure+tobacco+product+brands.&rft.au=Parascandola%2C+Mark%3BAugustson%2C+Erik%3BO%27Connell%2C+Mary+E%3BMarcus%2C+Stephen&rft.aulast=Parascandola&rft.aufirst=Mark&rft.date=2009-07-01&rft.volume=11&rft.issue=7&rft.spage=886&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=1469-994X&rft_id=info:doi/10.1093%2Fntr%2Fntp082 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-10 N1 - Date created - 2009-06-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Tob Control. 2001 Jun;10(2):189-95 [11387543] Tob Control. 2004 Jun;13(2):108-13 [15175521] Tob Control. 2003 Dec;12(4):383-90 [14660773] Tob Control. 2004 Mar;13(1):78-84 [14985602] Cancer Nurs. 2003 Dec;26(6):454-65; quiz 466-7 [15022977] Tob Control. 2004 Jun;13(2):123-8 [15175526] J Health Commun. 2004 Sep-Oct;9(5):443-60; discussion 81-4 [15513791] MMWR CDC Surveill Summ. 1994 Nov 18;43(3):1-43 [7969014] Am J Prev Med. 1998 Jul;15(1):9-16 [9651633] J Behav Med. 2004 Aug;27(4):413-24 [15559736] Tob Control. 2005 Feb;14(1):55-9 [15735301] Nicotine Tob Res. 2004 Dec;6 Suppl 3:S311-21 [15799594] Nicotine Tob Res. 2004 Dec;6 Suppl 3:S323-32 [15799595] Nicotine Tob Res. 2004 Dec;6 Suppl 3:S353-62 [15799598] Am J Prev Med. 2005 Aug;29(2):85-90 [16005803] Tob Control. 2006 Feb;15(1):39-44 [16436404] J Health Commun. 2006;11 Suppl 1:51-69 [16641074] Nicotine Tob Res. 2006 Dec;8(6):791-7 [17132527] Nicotine Tob Res. 2007 May;9(5):525-34 [17454709] Am J Health Behav. 2007 Sep-Oct;31(5):526-34 [17555383] Tob Control. 2007 Oct;16(5):306-11 [17897988] Am J Health Behav. 2008 Jul-Aug;32(4):431-7 [18092903] Tob Control. 2001;10 Suppl 1:i17-23 [11740040] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/ntr/ntp082 ER - TY - JOUR T1 - Coexpression of IL-18 strongly attenuates IL-12-induced systemic toxicity through a rapid induction of IL-10 without affecting its antitumor capacity. AN - 67402521; 19535628 AB - IL-12 is an excellent candidate for the treatment of cancer due to its ability to drive strong antitumor responses. Recombinant IL-12 protein is currently used in cancer patients; however, systemic expression of rIL-12 presents disadvantages including cost and dose limitation due to its toxicity. In this study, we used hydrodynamic shear of cDNA as a tool to achieve systemic expression of IL-12. We found that sustained but toxic levels of serum IL-12 could be generated in 6- to 7-wk-old B6 mice after a single injection of the cDNA. Unexpectedly, we observed that when IL-12 cDNA is coinjected with IL-18 cDNA, IL-12 antitumor activity was maintained, but there was a significant attenuation of IL-12 toxicity, as evidenced by a greater survival index and a diminution of liver enzymes (ALT and AST). Interestingly, after IL-12 plus IL-18 cDNA administration, more rapid and higher IL-10 levels were observed than after IL-12 cDNA treatment alone. To understand the mechanism of protection, we coinjected IL-12 plus IL-10 cDNAs and observed an increase in survival that correlated with diminished serum levels of the inflammatory cytokines TNF-alpha and IFN-gamma. Confirming the protective role of early IL-10 expression, we observed a significant decrease in survival in IL-10 knockout mice or IL-10R-blocked B6 mice after IL-12 plus IL-18 treatment. Thus, our data demonstrate that the high and early IL-10 expression induced after IL-12 plus IL-18 cDNA treatment is critical to rapidly attenuate IL-12 toxicity without affecting its antitumor capacity. These data could highly contribute to the design of more efficient/less toxic protocols for the treatment of cancer. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Rodriguez-Galan, Maria Cecilia AU - Reynolds, Della AU - Correa, Silvia G AU - Iribarren, Pablo AU - Watanabe, Morihiro AU - Young, Howard A AD - Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. crodri@bioclin.fcq.unc.edu.ar Y1 - 2009/07/01/ PY - 2009 DA - 2009 Jul 01 SP - 740 EP - 748 VL - 183 IS - 1 KW - Antineoplastic Agents KW - 0 KW - DNA, Complementary KW - Interleukin-18 KW - Tumor Necrosis Factor-alpha KW - Interleukin-10 KW - 130068-27-8 KW - Interleukin-12 KW - 187348-17-0 KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Interferon-gamma -- antagonists & inhibitors KW - Cell Line, Tumor KW - Mice KW - Mice, Inbred BALB C KW - Mice, Knockout KW - Drug Therapy, Combination KW - Interferon-gamma -- deficiency KW - Mice, Inbred C57BL KW - Tumor Necrosis Factor-alpha -- blood KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - DNA, Complementary -- administration & dosage KW - Interferon-gamma -- blood KW - DNA, Complementary -- biosynthesis KW - Survival Analysis KW - Interleukin-18 -- therapeutic use KW - Interleukin-10 -- therapeutic use KW - Lung Neoplasms -- secondary KW - Lung Neoplasms -- immunology KW - Antineoplastic Agents -- metabolism KW - Melanoma, Experimental -- mortality KW - Lung Neoplasms -- therapy KW - Antineoplastic Agents -- blood KW - Interleukin-12 -- blood KW - Melanoma, Experimental -- therapy KW - Melanoma, Experimental -- immunology KW - Interleukin-12 -- toxicity KW - Interleukin-10 -- deficiency KW - Interleukin-12 -- biosynthesis KW - Interleukin-18 -- biosynthesis KW - Lung Neoplasms -- mortality KW - Interleukin-10 -- biosynthesis KW - Interleukin-12 -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Interleukin-18 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67402521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Coexpression+of+IL-18+strongly+attenuates+IL-12-induced+systemic+toxicity+through+a+rapid+induction+of+IL-10+without+affecting+its+antitumor+capacity.&rft.au=Rodriguez-Galan%2C+Maria+Cecilia%3BReynolds%2C+Della%3BCorrea%2C+Silvia+G%3BIribarren%2C+Pablo%3BWatanabe%2C+Morihiro%3BYoung%2C+Howard+A&rft.aulast=Rodriguez-Galan&rft.aufirst=Maria&rft.date=2009-07-01&rft.volume=183&rft.issue=1&rft.spage=740&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.0804166 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-20 N1 - Date created - 2009-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 1999 Dec;5(12):3983-9 [10632329] Gene Ther. 1999 Jul;6(7):1258-66 [10455434] Clin Cancer Res. 2000 May;6(5):1678-92 [10815886] Blood. 2000 Aug 15;96(4):1465-73 [10942393] Annu Rev Immunol. 2001;19:423-74 [11244043] Clin Cancer Res. 2001 Mar;7(3 Suppl):895s-901s [11300489] Gene Ther. 2001 Feb;8(4):259-67 [11313799] J Gene Med. 2001 Jul-Aug;3(4):384-93 [11529668] Ann N Y Acad Sci. 2001 Sep;941:177-84 [11594571] Blood. 2002 Jan 1;99(1):67-74 [11756154] J Immunol. 2005 Jun 1;174(11):6663-71 [15905505] Clin Immunol. 2005 Aug;116(2):158-65 [15993363] Infect Immun. 2005 Oct;73(10):6537-46 [16177328] Clin Exp Immunol. 2006 Jan;143(1):41-9 [16367932] Lab Invest. 2006 Mar;86(3):254-61 [16446706] Clinics (Sao Paulo). 2006 Feb;61(1):71-6 [16532228] Clin Cancer Res. 2007 Jan 1;13(1):215-22 [17200357] J Exp Med. 2007 Feb 19;204(2):273-83 [17283209] J Immunol. 1999 Nov 15;163(10):5269-77 [10553049] Nat Rev Immunol. 2007 Jun;7(6):425-8 [17525751] Crit Rev Immunol. 2007;27(5):401-14 [18197804] Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):266-70 [18220947] J Transl Med. 2007;5:66 [18076766] J Cell Mol Med. 2009 Aug;13(8B):1962-76 [18624776] J Immunol. 2005 Mar 1;174(5):2796-804 [15728489] Hum Gene Ther. 2002 Jan 20;13(2):177-85 [11812275] Clin Cancer Res. 2002 Nov;8(11):3383-93 [12429625] Clin Cancer Res. 2003 Jan;9(1):76-83 [12538454] Nat Rev Immunol. 2003 Feb;3(2):133-46 [12563297] Cancer Immunol Immunother. 2003 Mar;52(3):133-44 [12649742] Curr Pharm Des. 2003;9(24):1981-91 [12871184] Clin Cancer Res. 2004 Mar 15;10(6):1935-42 [15041709] Clin Cancer Res. 2004 Aug 15;10(16):5432-8 [15328181] Am J Pathol. 1995 Dec;147(6):1693-707 [7495294] J Immunol. 1996 Apr 15;156(8):2776-82 [8609396] Blood. 1996 May 1;87(9):3877-82 [8611715] J Exp Med. 1996 Jun 1;183(6):2559-69 [8676077] Am J Pathol. 1997 May;150(5):1869-80 [9137109] Chem Immunol. 1997;68:153-74 [9329221] J Immunol. 1998 Feb 15;160(4):1742-9 [9469432] J Clin Invest. 1998 Mar 15;101(6):1441-52 [9502787] Annu Rev Immunol. 1998;16:495-521 [9597139] Adv Immunol. 1998;70:83-243 [9755338] Clin Cancer Res. 1997 Mar;3(3):409-17 [9815699] J Immunol. 1999 Jan 15;162(2):1049-55 [9916732] Clin Cancer Res. 1999 Jan;5(1):9-16 [9918197] J Immunother. 1999 Mar;22(2):135-44 [10093038] J Immunol. 1999 Apr 15;162(8):4511-20 [10201989] J Immunol. 1999 Apr 15;162(8):4943-51 [10202041] J Immunol. 1999 May 1;162(9):5070-7 [10227975] J Immunol. 1999 Jul 15;163(2):583-9 [10395644] J Immunol. 2000 Mar 15;164(6):3330-6 [10706727] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.0804166 ER - TY - JOUR T1 - Preoperative weekly cisplatin-epirubicin-paclitaxel with G-CSF support in triple-negative large operable breast cancer. AN - 67395706; 19218307 AB - Findings from our previously published phase II study showed a high pathologic complete remission (pCR) rate in patients with triple-negative large operable breast cancer after the administration of eight cisplatin-epirubicin-paclitaxel (PET) weekly cycles. The safety and efficacy data of the initial population were updated, with inclusion of additional experience with the same therapy. Patients with triple-negative large operable breast cancer (T2-T3 N0-1; T > 3 cm) received eight preoperative weekly cycles of cisplatin 30 mg/m2, epirubicin 50 mg/m2, paclitaxel (Taxol) 120 mg/m2, with granulocyte colony-stimulating factor (5 microg/kg days 3-5) support. Overall 74 consecutive patients (T2/T3 = 35/39; N0/N+ = 26/48) were treated, from May 1999 to May 2008. At pathological assessment, 46 women (62%; 95% confidence interval 50-73) showed pCR in both breast and axilla. At a 41-month median follow-up (range 3-119), 13 events (nine distant metastases) had occurred, 5-year projected disease-free survival (DFS) and distant disease-free survival being 76% and 84%, respectively. Five-year DFS was 90% and 56% in pCRs and non-pCRs, respectively. Severe neutropenia and anemia occurred in 23 (31%) and eight (10.8%) patients, respectively. Severe non-hematological toxicity was recorded in <20% of patients. Peripheral neuropathy was quite frequent but never severe. Eight weekly PET cycles are a highly effective primary treatment in women with triple-negative large operable breast cancer. This approach results in a very promising long-term DFS in this poor prognosis population. This triplet regimen is worthy of evaluation in phase III trials. JF - Annals of oncology : official journal of the European Society for Medical Oncology AU - Frasci, G AU - Comella, P AU - Rinaldo, M AU - Iodice, G AU - Di Bonito, M AU - D'Aiuto, M AU - Petrillo, A AU - Lastoria, S AU - Siani, C AU - Comella, G AU - D'Aiuto, G AD - Department of Senology, Unit of Preoperative Treatments, National Cancer Institute of Naples, Naples, Italy. giuseppe.frasci@libero.it Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1185 EP - 1192 VL - 20 IS - 7 KW - PET regimen KW - 0 KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Epirubicin KW - 3Z8479ZZ5X KW - Paclitaxel KW - P88XT4IS4D KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Preoperative Care KW - Paclitaxel -- administration & dosage KW - Disease-Free Survival KW - Drug Administration Schedule KW - Humans KW - Aged KW - Cisplatin -- administration & dosage KW - Adult KW - Treatment Outcome KW - Neoplasm Metastasis KW - Follow-Up Studies KW - Middle Aged KW - Epirubicin -- administration & dosage KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Granulocyte Colony-Stimulating Factor -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67395706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.atitle=Preoperative+weekly+cisplatin-epirubicin-paclitaxel+with+G-CSF+support+in+triple-negative+large+operable+breast+cancer.&rft.au=Frasci%2C+G%3BComella%2C+P%3BRinaldo%2C+M%3BIodice%2C+G%3BDi+Bonito%2C+M%3BD%27Aiuto%2C+M%3BPetrillo%2C+A%3BLastoria%2C+S%3BSiani%2C+C%3BComella%2C+G%3BD%27Aiuto%2C+G&rft.aulast=Frasci&rft.aufirst=G&rft.date=2009-07-01&rft.volume=20&rft.issue=7&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.issn=1569-8041&rft_id=info:doi/10.1093%2Fannonc%2Fmdn748 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-25 N1 - Date created - 2009-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annonc/mdn748 ER - TY - JOUR T1 - Sulfate-conjugated methylprednisolone as a colon-targeted methylprednisolone prodrug with improved therapeutic properties against rat colitis. AN - 67380849; 19527116 AB - Methylprednisolone (MP) is one of the most widely used corticosteroids for the treatment of inflammatory bowel disease (IBD). However, systemic adverse effects of MP limit its availability for the disease. In present study, sulfate-conjugated methylprednisolone (MPS) was evaluated in vivo as a colon-targeted prodrug of MP and its therapeutic properties against 2,4,6-trinitrobenzenesulfonic acid-induced rat colitis were investigated. Upon oral administration, a large fraction of MPS reached the large intestine, where MPS was converted to MP implying that MPS would deliver MP effectively to the large intestine. The fecal recovery of MP (after MPS administration) was much greater than that after MP administration and the urinary recovery of MP (after MPS administration) was much less than that after MP administration, suggesting that MPS should exhibit enhanced therapeutic activity and reduced systemic adverse effects. Consistent with this notion, MPS was more effective than MP in ameliorating rat colitis. Moreover, the adverse effects of MPS on adrenal function and thymus were much lower than those of MP. Taken together, MPS may be therapeutically superior to MP in IBD treatment. JF - Journal of drug targeting AU - Kong, Hyesik AU - Lee, Younghyun AU - Hong, Sungchae AU - Han, Jeongoh AU - Choi, Biom AU - Jung, Yunjin AU - Kim, Young Mi AD - Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 450 EP - 458 VL - 17 IS - 6 KW - Glucocorticoids KW - 0 KW - Prodrugs KW - Sulfates KW - Trinitrobenzenesulfonic Acid KW - 8T3HQG2ZC4 KW - Methylprednisolone KW - X4W7ZR7023 KW - Index Medicus KW - Rats KW - Administration, Oral KW - Drug Delivery Systems KW - Animals KW - Rats, Sprague-Dawley KW - Disease Models, Animal KW - Adrenal Glands -- drug effects KW - Sulfates -- chemistry KW - Thymus Gland -- drug effects KW - Male KW - Methylprednisolone -- pharmacokinetics KW - Glucocorticoids -- pharmacokinetics KW - Glucocorticoids -- chemistry KW - Colon -- metabolism KW - Glucocorticoids -- adverse effects KW - Colitis -- drug therapy KW - Methylprednisolone -- chemistry KW - Methylprednisolone -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67380849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+drug+targeting&rft.atitle=Sulfate-conjugated+methylprednisolone+as+a+colon-targeted+methylprednisolone+prodrug+with+improved+therapeutic+properties+against+rat+colitis.&rft.au=Xie%2C+Yi%3BKole%2C+Sutapa%3BPrecht%2C+Patricia%3BPazin%2C+Michael+J%3BBernier%2C+Michel&rft.aulast=Xie&rft.aufirst=Yi&rft.date=2009-03-01&rft.volume=150&rft.issue=3&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2008-1241 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-02 N1 - Date created - 2009-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10611860902974077 ER - TY - JOUR T1 - The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis. AN - 67379033; 19058256 AB - Expression of the PMLRARalpha fusion dominant-negative oncogene in the epidermis of transgenic mice resulted in spontaneous skin tumors attributed to changes in both the PML and RAR pathways [Hansen et al., Cancer Res 2003; 63:5257-5265]. To determine the contribution of PML to skin tumor susceptibility, transgenic mice were generated on an FVB/N background, that overexpressed the human PML protein in epidermis and hair follicles under the control of the bovine keratin 5 promoter. PML was highly expressed in the epidermis and hair follicles of these mice and was also increased in cultured keratinocytes where it was confined to nuclear bodies. While an overt skin phenotype was not detected in young transgenic mice, expression of keratin 10 (K10) was increased in epidermis and hair follicles and cultured keratinocytes. As mice aged, they exhibited extensive alopecia that was accentuated on the C57BL/6J background. Following skin tumor induction with 7, 12-dimethylbenz[a]anthracene (DMBA) as initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as promoter, papilloma multiplicity and size were decreased in the transgenic mice by 35%, and the conversion of papillomas to carcinomas was delayed. Cultured transgenic keratinocytes underwent premature senescence and upregulated transcripts for p16 and Rb but not p19 and p53. Together, these changes suggest that PML participates in regulating the growth and differentiation of keratinocytes that likely influence its activity as a suppressor for tumor development. JF - Molecular carcinogenesis AU - Virador, Victoria M AU - Flores-Obando, Rafael E AU - Berry, Adam AU - Patel, Rinal AU - Zakhari, Julia AU - Lo, Yu-Chien AU - Strain, Kathryn AU - Anders, Joanna AU - Cataisson, Christophe AU - Hansen, Laura A AU - Yuspa, Stuart H AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research. National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 599 EP - 609 VL - 48 IS - 7 KW - Carcinogens KW - 0 KW - DNA Primers KW - Nuclear Proteins KW - Promyelocytic Leukemia Protein KW - Transcription Factors KW - Tumor Suppressor Proteins KW - PML protein, human KW - 143220-95-5 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Tetradecanoylphorbol Acetate -- toxicity KW - Polymerase Chain Reaction KW - Animals KW - Base Sequence KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Humans KW - Mice, Inbred C57BL KW - Carcinogens -- toxicity KW - Mice KW - Mice, Transgenic KW - Skin Neoplasms -- genetics KW - Transcription Factors -- physiology KW - Nuclear Proteins -- genetics KW - Tumor Suppressor Proteins -- physiology KW - Genes, Tumor Suppressor KW - Skin Neoplasms -- chemically induced KW - Tumor Suppressor Proteins -- genetics KW - Transcription Factors -- genetics KW - Nuclear Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67379033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=The+role+of+cannabis+use+within+a+dimensional+approach+to+cannabis+use+disorders&rft.au=Compton%2C+Wilson+M%3BSaha%2C+Tulshi+D%3BConway%2C+Kevin+P%3BGrant%2C+Bridget+F&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2009-03-01&rft.volume=100&rft.issue=3&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2008.10.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-26 N1 - Date created - 2009-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2002 May 24;277(21):19122-30 [11889133] Oncogene. 2001 Oct 29;20(49):7223-33 [11704850] Oncogene. 2003 Apr 17;22(15):2285-95 [12700664] Cancer Res. 2003 Sep 1;63(17):5257-65 [14500356] Chin Med J (Engl). 2003 Sep;116(9):1394-8 [14527374] Oncogene. 2003 Dec 8;22(56):9048-57 [14663483] J Natl Cancer Inst. 2004 Feb 18;96(4):269-79 [14970276] Mol Cell. 2004 Feb 27;13(4):523-35 [14992722] J Exp Med. 2001 Feb 19;193(4):521-29 [11181703] Cancer Lett. 2006 May 18;236(2):259-68 [16216409] Oncogene. 2001 Oct 29;20(49):7250-6 [11704853] Oncogene. 2001 Oct 29;20(49):7266-73 [11704855] Cell. 2002 Jan 25;108(2):165-70 [11832207] Carcinogenesis. 1982;3(4):403-7 [6807562] Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2065-9 [1848692] Cell. 1991 Aug 23;66(4):663-74 [1652368] Cancer Lett. 1991 Sep;59(3):251-6 [1680544] J Invest Dermatol. 1993 Jul;101(1 Suppl):27S-32S [8326151] Cell. 1993 Sep 10;74(5):813-22 [8374952] Carcinogenesis. 1993 Nov;14(11):2353-8 [8242866] Cell. 1994 Jan 28;76(2):333-43 [8293467] Cancer Res. 1994 Mar 1;54(5):1178-89 [8118803] Cancer Res. 1994 Nov 1;54(21):5584-92 [7923201] Differentiation. 1994 Nov;58(1):53-64 [7532601] Oncogene. 1995 Apr 6;10(7):1315-24 [7731682] Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9363-7 [7568133] Methods Enzymol. 1995;254:3-20 [8531694] Cancer Res. 1997 May 15;57(10):1868-72 [9157977] Bone Marrow Transplant. 1997 Jun;19(11):1125-8 [9193756] Carcinogenesis. 1997 Nov;18(11):2063-9 [9395203] Science. 1998 Mar 6;279(5356):1547-51 [9488655] Oncogene. 1998 Apr 9;16(14):1839-49 [9583681] Mol Cell Biol. 1999 Apr;19(4):3086-94 [10082575] Blood. 1999 May 15;93(10):3167-215 [10233871] Cancer Gene Ther. 2005 Jan;12(1):1-11 [15529177] Mol Cell Biol. 2005 Feb;25(3):1013-24 [15657429] Acta Pharmacol Sin. 2005 May;26(5):610-5 [15842782] Science. 2005 Aug 19;309(5738):1253-6 [16037417] Genes Dev. 2005 Sep 1;19(17):1986-99 [16107615] Cancer Res. 2002 Oct 15;62(20):5947-54 [12384561] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20498 ER - TY - JOUR T1 - Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of alpha4beta2 nicotinic receptors in rats. AN - 67374248; 19393252 AB - Varenicline, a partial alpha4beta2 and full alpha7 nicotinic receptor agonist, has been shown to inhibit nicotine self-administration and nicotine-induced increases in extracellular dopamine in the nucleus accumbens. In the present study, we investigated whether varenicline inhibits nicotine-enhanced electrical brain-stimulation reward (BSR), and if so, which receptor subtypes are involved. Systemic administration of nicotine (0.25-1.0 mg/kg, i.p.) or varenicline (0.03-3 mg/kg, i.p.) produced biphasic effects, with low doses producing enhancement (e.g., decreased BSR threshold), and high doses inhibiting BSR. Pretreatment with low dose (0.03-1.0 mg/kg) varenicline dose-dependently attenuated nicotine (0.25 or 0.5 mg/kg)-enhanced BSR. The BSR-enhancing effect produced by varenicline was blocked by mecamylamine (a high affinity nicotinic receptor antagonist) or dihydro-beta-erythroidine (a relatively selective nicotinic alpha4-containing receptor antagonist), but not methyllycaconitine (a selective alpha7 receptor antagonist), suggesting an effect mediated by activation of alpha4beta2 receptors. This suggestion is supported by findings that the alpha4beta2 receptor agonist SIB-1765F produced a dose-dependent enhancement of BSR, while pretreatment with SIB-1765F attenuated nicotine (0.5 mg/kg)-enhanced BSR. In contrast, the selective alpha7 receptor agonist ARR-17779, altered neither BSR itself nor nicotine-enhanced BSR, at any dose tested. These findings suggest that: 1) varenicline inhibits nicotine-enhanced BSR, supporting its use as a smoking cessation aid; and 2) varenicline-enhanced BSR by itself and varenicline's anti-nicotine effects are mediated by activation of alpha4beta2, but not alpha7, receptors. JF - Neuropharmacology AU - Spiller, Krista AU - Xi, Zheng-Xiong AU - Li, Xia AU - Ashby, Charles R AU - Callahan, Patrick M AU - Tehim, Ashok AU - Gardner, Eliot L AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 60 EP - 66 VL - 57 IS - 1 KW - Benzazepines KW - 0 KW - Nicotinic Agonists KW - Nicotinic Antagonists KW - Quinoxalines KW - Receptors, Nicotinic KW - nicotinic receptor alpha4beta2 KW - Nicotine KW - 6M3C89ZY6R KW - Varenicline KW - W6HS99O8ZO KW - Index Medicus KW - Rats KW - Animals KW - Electric Stimulation -- methods KW - Drug Interactions KW - Rats, Long-Evans KW - Medial Forebrain Bundle -- drug effects KW - Medial Forebrain Bundle -- physiology KW - Dose-Response Relationship, Drug KW - Nicotinic Antagonists -- pharmacology KW - Male KW - Conditioning, Operant -- drug effects KW - Benzazepines -- pharmacology KW - Reward KW - Receptors, Nicotinic -- metabolism KW - Conditioning, Operant -- physiology KW - Nicotine -- pharmacology KW - Nicotinic Agonists -- pharmacology KW - Quinoxalines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67374248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Varenicline+attenuates+nicotine-enhanced+brain-stimulation+reward+by+activation+of+alpha4beta2+nicotinic+receptors+in+rats.&rft.au=Spiller%2C+Krista%3BXi%2C+Zheng-Xiong%3BLi%2C+Xia%3BAshby%2C+Charles+R%3BCallahan%2C+Patrick+M%3BTehim%2C+Ashok%3BGardner%2C+Eliot+L&rft.aulast=Spiller&rft.aufirst=Krista&rft.date=2009-07-01&rft.volume=57&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=1873-7064&rft_id=info:doi/10.1016%2Fj.neuropharm.2009.04.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-01 N1 - Date created - 2009-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2005 Jul 7;436(7047):103-7 [16001069] J Med Chem. 2005 May 19;48(10):3474-7 [15887955] Int J Clin Pract. 2006 May;60(5):571-6 [16700857] Mol Pharmacol. 2006 Sep;70(3):801-5 [16766716] Int J Neuropsychopharmacol. 2006 Oct;9(5):585-602 [16942635] Psychopharmacology (Berl). 2007 Feb;190(2):157-70 [17115136] Ann Pharmacother. 2007 Jan;41(1):95-9 [17190845] Neuropharmacology. 2007 Mar;52(3):985-94 [17157884] Trends Pharmacol Sci. 2007 Jul;28(7):316-25 [17573127] Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12518-23 [17626178] Psychopharmacology (Berl). 2008 Mar;196(4):533-42 [17985117] Nicotine Tob Res. 2008 Jun;10(6):995-1008 [18584463] Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3159-68 [18640919] Expert Opin Investig Drugs. 2008 Oct;17(10):1473-85 [18808308] Acta Pharmacol Sin. 2009 Jun;30(6):723-39 [19434058] Neuropharmacology. 2000 Oct;39(13):2840-7 [11044754] Nicotine Tob Res. 2000 Feb;2(1):19-37 [11072438] J Neurochem. 2001 Jan;76(1):258-68 [11145999] J Neurosci. 2001 Mar 1;21(5):1452-63 [11222635] Pharmacol Ther. 2001 Nov-Dec;92(2-3):89-108 [11916531] Neuropharmacology. 2002 Mar;42(4):530-9 [11955523] Neuroscience. 2002;115(1):137-44 [12401328] J Neurobiol. 2002 Dec;53(4):447-56 [12436412] Neuropsychopharmacology. 2003 Feb;28(2):216-25 [12589374] Psychopharmacology (Berl). 2003 Mar;166(3):306-13 [12569428] Med Res Rev. 2003 Jul;23(4):393-426 [12710018] Eur J Neurosci. 2003 Apr;17(7):1329-37 [12713636] Psychopharmacology (Berl). 2003 Jul;168(3):347-58 [12698231] Trends Pharmacol Sci. 2003 Sep;24(9):493-9 [12967775] Neuropharmacology. 2004 Mar;46(3):363-71 [14975691] Neuroscience. 2004;124(4):817-22 [15026122] Psychopharmacology (Berl). 2004 Apr;172(4):375-83 [14727003] Mol Pharmacol. 2004 Jun;65(6):1526-35 [15155845] J Pharmacol Exp Ther. 2004 Oct;311(1):80-91 [15178698] Science. 1981 Oct 30;214(4520):573-5 [7291998] J Neurosci. 1984 Dec;4(12):2906-11 [6502210] Pharmacol Biochem Behav. 1985 Feb;22(2):237-41 [2858867] Pharmacol Biochem Behav. 1986 Nov;25(5):1041-9 [3786357] Neuron. 1990 Dec;5(6):847-56 [1702646] Nature. 1991 Mar 21;350(6315):235-8 [2005979] Pharmacol Biochem Behav. 1992 Apr;41(4):755-9 [1594644] J Neurosci. 1992 Jul;12(7):2765-84 [1613557] Eur J Pharmacol. 1996 Apr 22;301(1-3):1-5 [8773440] Annu Rev Neurosci. 1996;19:319-40 [8833446] J Neurochem. 1996 Nov;67(5):1953-9 [8863500] J Pharmacol Exp Ther. 1997 Jan;280(1):373-83 [8996218] J Pharmacol Exp Ther. 1997 Jan;280(1):384-92 [8996219] Nature. 1998 Jan 8;391(6663):173-7 [9428762] J Neurosci. 1998 Jun 15;18(12):4461-72 [9614223] Behav Brain Res. 1998 Nov;96(1-2):185-8 [9821554] Pharmacol Biochem Behav. 1999 Apr;62(4):743-51 [10208381] Science. 2004 Nov 5;306(5698):1029-32 [15528443] Neuropharmacology. 2005 Jan;48(1):72-9 [15617729] Curr Pharm Des. 2006;12(4):407-28 [16472136] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuropharm.2009.04.006 ER - TY - JOUR T1 - Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein. AN - 67363177; 19403678 AB - Viruses such as hepatitis C and the severe acute respiratory syndrome coronavirus (SARS-CoV) encode proteins that are distributed between mitochondria and the nucleus, but little is known about the factors that control partitioning between these sites. SARS-CoV encodes a unique accessory gene called open reading frame (ORF) 3b that, like other unique accessory genes in SARS-CoV, likely contributes to viral pathogenicity. The ORF 3b protein is 154 amino acids and is predicted to express from the second ORF in subgenomic RNA3. In this report, we have characterized the molecular components that regulate intracellular localization of the ORF 3b protein. We demonstrate unique shuttling behavior of ORF 3b, whereby the protein initially accumulates in the nucleus and subsequently translocates to mitochondria. Following nuclear localization, ORF 3b traffics to the outer membrane of mitochondria via a predicted amphipathic alpha-helix. Additionally, ORF 3b contains a consensus nuclear export sequence, and we demonstrate that nuclear export and thus mitochondrial translocation are dependent on a leptomycin B-sensitive nuclear export mechanism. We further show that ORF 3b inhibits induction of type I interferon induced by retinoic acid-induced gene 1 and the mitochondrial antiviral signaling protein. Our observations provide insights into the cellular localization of ORF 3b that may enhance our understanding of the mechanisms by which ORF 3b contributes to SARS-CoV pathogenesis. The findings reported here reveal that for multilocalized proteins, consideration of the spatiotemporal distribution may be crucial for understanding viral protein behavior and function. JF - Journal of virology AU - Freundt, Eric C AU - Yu, Li AU - Park, Elizabeth AU - Lenardo, Michael J AU - Xu, Xiao-Ning AD - Laboratory of Immunology, Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 6631 EP - 6640 VL - 83 IS - 13 KW - Viral Structural Proteins KW - 0 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Active Transport, Cell Nucleus KW - Humans KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Vero Cells KW - Amino Acid Sequence KW - Mitochondrial Membranes -- metabolism KW - Cell Nucleus -- metabolism KW - Open Reading Frames KW - Viral Structural Proteins -- metabolism KW - SARS Virus -- genetics KW - Mitochondria -- metabolism KW - SARS Virus -- metabolism KW - Viral Structural Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67363177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Molecular+determinants+for+subcellular+localization+of+the+severe+acute+respiratory+syndrome+coronavirus+open+reading+frame+3b+protein.&rft.au=Qu%2C+Wei%3BLiu%2C+Jie%3BDill%2C+Anna+L%3BSaavedra%2C+Joseph+E%3BKeefer%2C+Larry+K%3BWaalkes%2C+Michael+P&rft.aulast=Qu&rft.aufirst=Wei&rft.date=2009-03-01&rft.volume=100&rft.issue=3&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=Cancer+science&rft.issn=1349-7006&rft_id=info:doi/10.1111%2Fj.1349-7006.2008.01050.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-18 N1 - Date created - 2009-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Gen Virol. 2001 Apr;82(Pt 4):871-82 [11257193] J Virol. 2008 Nov;82(21):10946-52 [18715912] EMBO J. 2001 Aug 15;20(16):4325-31 [11500358] J Biol Chem. 2001 Aug 24;276(34):31945-52 [11395500] Nat Med. 2001 Dec;7(12):1306-12 [11726970] Results Probl Cell Differ. 2002;35:67-91 [11791409] J Biol Chem. 2002 Sep 13;277(37):34424-33 [12093802] Science. 2003 May 30;300(5624):1394-9 [12730500] Science. 2003 May 30;300(5624):1377-8 [12775826] J Virol. 2003 Jul;77(13):7214-24 [12805420] Virus Res. 2003 Sep;95(1-2):13-22 [12921992] Virus Res. 2003 Sep;95(1-2):75-85 [12921997] Viral Immunol. 2003;16(4):461-74 [14733734] Virology. 2004 Jul 1;324(2):251-6 [15207612] Nat Immunol. 2004 Jul;5(7):730-7 [15208624] Mol Biol Cell. 2004 Oct;15(10):4749-60 [15292455] Cell. 1995 Aug 11;82(3):475-83 [7543368] Cell. 1997 Sep 19;90(6):1051-60 [9323133] Bioinformatics. 1998;14(10):892-3 [9927721] Oncogene. 1999 Aug 5;18(31):4505-14 [10442641] Biochim Biophys Acta. 2004 Dec 6;1659(2-3):178-89 [15576050] J Virol. 2005 Jan;79(2):1271-81 [15613354] J Virol. 2005 Feb;79(4):2079-86 [15681410] J Virol. 2005 Mar;79(5):3182-6 [15709039] Trends Cell Biol. 2005 Mar;15(3):121-4 [15752974] Virol J. 2005;2:66 [16107218] Mod Pathol. 2005 Nov;18(11):1432-9 [15920543] Virus Res. 2005 Dec;114(1-2):70-9 [16046244] J Virol. 2005 Dec;79(23):14909-22 [16282490] Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17717-22 [16301520] Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17539-40 [16314558] Mol Cells. 2006 Apr 30;21(2):186-91 [16682811] Oncogene. 2006 Aug 7;25(34):4725-43 [16892086] Virus Res. 2006 Dec;122(1-2):20-7 [16965829] J Virol. 2007 Jan;81(2):964-76 [17093192] J Exp Med. 2000 Jan 3;191(1):33-46 [10620603] J Biol Chem. 2000 May 26;275(21):16202-12 [10821866] Science. 2000 Aug 18;289(5482):1159-64 [10947977] Virology. 2000 Nov 10;277(1):127-35 [11062043] J Virol. 2001 Feb;75(3):1522-32 [11152524] J Virol. 2007 Jan;81(2):548-57 [17108024] Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7253-8 [17438296] J Virol. 2007 May;81(10):5423-6 [17344286] J Biol Chem. 2001 Jun 22;276(25):22797-803 [11287420] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00367-09 ER - TY - JOUR T1 - Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage. AN - 67356922; 19149911 AB - Accumulating evidence suggests that mitochondrial dysfunction plays a critical role in the progression of a variety of neurodegenerative and psychiatric disorders. Thus, enhancing mitochondrial function could potentially help ameliorate the impairments of neural plasticity and cellular resilience associated with a variety of neuropsychiatric disorders. A series of studies was undertaken to investigate the effects of mood stabilizers on mitochondrial function, and against mitochondrially mediated neurotoxicity. We found that long-term treatment with lithium and valproate (VPA) enhanced cell respiration rate. Furthermore, chronic treatment with lithium or VPA enhanced mitochondrial function as determined by mitochondrial membrane potential, and mitochondrial oxidation in SH-SY5Y cells. In-vivo studies showed that long-term treatment with lithium or VPA protected against methamphetamine (Meth)-induced toxicity at the mitochondrial level. Furthermore, these agents prevented the Meth-induced reduction of mitochondrial cytochrome c, the mitochondrial anti-apoptotic Bcl-2/Bax ratio, and mitochondrial cytochrome oxidase (COX) activity. Oligoarray analysis demonstrated that the gene expression of several proteins related to the apoptotic pathway and mitochondrial functions were altered by Meth, and these changes were attenuated by treatment with lithium or VPA. One of the genes, Bcl-2, is a common target for lithium and VPA. Knock-down of Bcl-2 with specific Bcl-2 siRNA reduced the lithium- and VPA-induced increases in mitochondrial oxidation. These findings illustrate that lithium and VPA enhance mitochondrial function and protect against mitochondrially mediated toxicity. These agents may have potential clinical utility in the treatment of other diseases associated with impaired mitochondrial function, such as neurodegenerative diseases and schizophrenia. JF - The international journal of neuropsychopharmacology AU - Bachmann, Rosilla F AU - Wang, Yun AU - Yuan, Peixiong AU - Zhou, Rulun AU - Li, Xiaoxia AU - Alesci, Salvatore AU - Du, Jing AU - Manji, Husseini K AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 805 EP - 822 VL - 12 IS - 6 KW - Aldehydes KW - 0 KW - Antimanic Agents KW - Central Nervous System Stimulants KW - MitoTracker Red 580 KW - Organic Chemicals KW - Proto-Oncogene Proteins c-bcl-2 KW - Proto-Oncogene Proteins c-jun KW - RNA, Small Interfering KW - bcl-2-Associated X Protein KW - mitotracker green FM KW - Methamphetamine KW - 44RAL3456C KW - Valproic Acid KW - 614OI1Z5WI KW - Cytochromes c KW - 9007-43-6 KW - Lithium KW - 9FN79X2M3F KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Electron Transport Complex IV KW - EC 1.9.3.1 KW - Index Medicus KW - Animals KW - Drug Interactions KW - Analysis of Variance KW - Oxygen Consumption -- drug effects KW - Cytochromes c -- metabolism KW - Rats, Inbred WKY KW - Humans KW - Oligonucleotide Array Sequence Analysis -- methods KW - Proto-Oncogene Proteins c-jun -- metabolism KW - Rats KW - Gene Expression Regulation -- drug effects KW - Electron Transport Complex IV -- metabolism KW - Brain -- ultrastructure KW - Neuroblastoma -- ultrastructure KW - Time Factors KW - Male KW - Tyrosine 3-Monooxygenase -- metabolism KW - Dose-Response Relationship, Drug KW - Cell Line, Tumor KW - RNA, Small Interfering -- genetics KW - Transfection -- methods KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Proto-Oncogene Proteins c-bcl-2 -- genetics KW - Valproic Acid -- pharmacology KW - Central Nervous System Stimulants -- pharmacology KW - Antimanic Agents -- pharmacology KW - Mitochondria -- drug effects KW - Methamphetamine -- pharmacology KW - Lithium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67356922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Polychlorinated+biphenyls+and+risk+of+testicular+germ+cell+tumors.&rft.au=McGlynn%2C+Katherine+A%3BQuraishi%2C+Sabah+M%3BGraubard%2C+Barry+I%3BWeber%2C+Jean-Philippe%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2009-03-01&rft.volume=69&rft.issue=5&rft.spage=1901&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-3935 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-18 N1 - Date created - 2009-06-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res Mol Brain Res. 2001 Sep 10;93(1):64-9 [11532339] Am J Med Genet. 2001 Spring;106(1):27-36 [11579422] Nat Genet. 2001 Dec;29(4):389-95 [11726925] J Neurochem. 2002 Jul;82(1):137-45 [12091474] Neuroscience. 2003;116(2):485-9 [12559103] J Biol Chem. 2003 Aug 29;278(35):33067-77 [12796505] J Comp Neurol. 2003 Nov 24;466(4):478-94 [14566944] Arch Gen Psychiatry. 2004 Mar;61(3):300-8 [14993118] Neurochem Res. 2004 Mar;29(3):531-46 [15038601] Biol Psychiatry. 2004 Apr 1;55(7):676-84 [15038995] J Neurosci. 2004 Jul 21;24(29):6578-89 [15269270] Acta Psychiatr Scand. 1981 Oct;64(4):314-9 [6801927] Pharmacopsychiatry. 1984 Nov;17(6):199-201 [6514783] J Hepatol. 1985;1(5):453-65 [3932513] Ann Neurol. 1994 Nov;36(5):747-51 [7979220] Acta Neurobiol Exp (Wars). 1994;54(3):227-34 [7817838] Am J Psychiatry. 1996 Jun;153(6):765-70 [8633687] Semin Neurol. 1996 Mar;16(1):11-20 [8879052] Science. 1997 Feb 21;275(5303):1132-6 [9027315] Annu Rev Neurosci. 1997;20:245-67 [9056714] Adv Pharmacol. 1998;42:703-6 [9327996] Brain Res Brain Res Protoc. 1998 Mar;2(3):209-14 [9507134] Life Sci. 1998;63(5):357-68 [9714423] Science. 1998 Aug 28;281(5381):1322-6 [9735050] Adv Biochem Eng Biotechnol. 1998;62:75-105 [9755641] Int J Radiat Oncol Biol Phys. 1998 Nov 1;42(4):871-6 [9845113] J Biol Chem. 1999 Jan 1;274(1):129-34 [9867820] J Neurochem. 1999 Feb;72(2):879-82 [9930766] J Biol Chem. 1999 Mar 5;274(10):6039-42 [10037682] J Clin Psychiatry. 1999;60 Suppl 2:27-39; discussion 40-1, 113-6 [10073385] Cell Death Differ. 1998 Oct;5(10):805-15 [10203696] Exp Neurol. 2004 Dec;190(2):525-34 [15530891] Free Radic Biol Med. 2005 Mar 15;38(6):687-97 [15721979] Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):11-22 [15950756] J Clin Psychopharmacol. 2005 Aug;25(4):376-80 [16012283] J Neurochem. 2005 Oct;95(2):429-36 [16086684] FASEB J. 2005 Nov;19(13):1899-901 [16148027] Int Rev Neurobiol. 2005;67:73-94 [16291020] Neurotox Res. 2005 Nov;8(3-4):199-206 [16371314] Neuroscience. 2006;138(4):1341-9 [16413133] CNS Spectr. 2006 Apr;11(4):312-20; quiz 323-4 [16641836] Eur J Pharmacol. 2006 Jun 6;539(1-2):18-26 [16678157] AAPS J. 2006;8(2):E413-8 [16808044] Drug News Perspect. 2006 Dec;19(10):597-602 [17299601] Ann Thorac Surg. 2007 Mar;83(3):1102-9 [17307466] Toxicol Appl Pharmacol. 2007 May 1;220(3):243-51 [17350664] J Neurosci. 2007 May 2;27(18):4894-901 [17475797] Biol Psychiatry. 2007 Jun 1;61(11):1235-43 [17161385] J Biol Chem. 2007 Jun 22;282(25):18057-68 [17485418] Biochim Biophys Acta. 2007 Sep;1767(9):1126-33 [17706936] Eur J Pharmacol. 2007 Nov 14;573(1-3):100-10 [17651730] Kidney Int. 2007 Dec;72(12):1493-502 [17914353] Cell Calcium. 2008 Jul;44(1):92-102 [18177933] Neuropsychopharmacology. 2008 Oct;33(11):2551-65 [18235426] J Inherit Metab Dis. 2008 Apr;31(2):205-16 [18392741] Neuropharmacology. 2002 May;42(6):837-45 [12015210] J Neurochem. 1999 Dec;73(6):2299-309 [10582587] Am J Physiol Lung Cell Mol Physiol. 2000 Apr;278(4):L858-63 [10749764] Cytometry. 2000 Jun 1;40(2):151-60 [10805935] J Clin Psychiatry. 2000;61 Suppl 9:82-96 [10826666] Eur J Pharmacol. 2000 Jun 9;398(1):11-8 [10856443] J Neurosci Methods. 2001 Jan 15;104(2):165-76 [11164242] Bipolar Disord. 2000 Sep;2(3 Pt 1):180-90 [11256685] FASEB J. 2001 Aug;15(10):1745-52 [11481222] J Biol Chem. 2001 Aug 24;276(34):31674-83 [11418608] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1017/S1461145708009802 ER - TY - JOUR T1 - beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. AN - 67349969; 19513519 AB - beta-Elemene, a new plant-derived anticancer agent with low toxicity, has been reported to be effective in the treatment of leukemia and solid tumors. In the current study, we explored the therapeutic application of beta-elemene in sensitizing lung cancer cells to cisplatin. beta-Elemene considerably enhanced the inhibitory effect of cisplatin on cell proliferation in a time- and dose-dependent manner in the human non-small cell lung cancer (NSCLC) cell lines H460 and A549. Furthermore, this effect of beta-elemene on cisplatin activity occurred through the induction of apoptosis in NSCLC cells, as assessed by an ELISA-based assay, TUNEL assay and annexin V binding assay. Consistent with these results, the protein levels of Bax and phospho-Bcl-2 increased and those of Bcl-2 and XIAP decreased in cells treated with beta-elemene in combination with cisplatin, compared with the levels in cells treated with either agent alone. Finally, beta-elemene augmented the cisplatin-induced increases in caspase-3, -7, -9 and -10 activities and cleaved caspase-3, -9 and poly(ADP-ribose) polymerase levels in NSCLC cells. These observations suggest that beta-elemene sensitizes NSCLC cells to cisplatin via a mitochondria-mediated intrinsic apoptosis pathway involving Bcl-2 family proteins and IAPs (inhibitor of apoptosis proteins). Our data provide a rationale for developing a combination of beta-elemene and cisplatin as a regimen for the treatment of lung carcinoma and other cisplatin-resistant tumors. JF - Oncology reports AU - Li, Qingdi Q AU - Wang, Gangduo AU - Zhang, Manchao AU - Cuff, Christopher F AU - Huang, Lan AU - Reed, Eddie AD - The Mary Babb Randolph Cancer Center and Department of Microbiology, Immunology and Cell Biology, Robert C. Byrd Health Sciences Center, West Virginia University of Medicine, Morgantown, WV 26506, USA. liquenti@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 161 EP - 170 VL - 22 IS - 1 SN - 1021-335X, 1021-335X KW - Antineoplastic Agents, Phytogenic KW - 0 KW - BAX protein, human KW - Proto-Oncogene Proteins c-bcl-2 KW - Sesquiterpenes KW - X-Linked Inhibitor of Apoptosis Protein KW - XIAP protein, human KW - bcl-2-Associated X Protein KW - beta-elemene KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Caspases KW - EC 3.4.22.- KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Dose-Response Relationship, Drug KW - Enzyme Activation KW - Humans KW - Cell Line, Tumor KW - X-Linked Inhibitor of Apoptosis Protein -- metabolism KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Caspases -- metabolism KW - bcl-2-Associated X Protein -- metabolism KW - Cisplatin -- administration & dosage KW - Mitochondria -- drug effects KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Mitochondria -- metabolism KW - Sesquiterpenes -- administration & dosage KW - Time Factors KW - Antineoplastic Agents, Phytogenic -- administration & dosage KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Apoptosis -- drug effects KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67349969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.atitle=Role+of+chemotherapy+in+Hodgkin%27s+lymphoma.&rft.au=Seam%2C+Pamela%3BJanik%2C+John+E%3BLongo%2C+Dan+L%3BDevita%2C+Vincent+T&rft.aulast=Seam&rft.aufirst=Pamela&rft.date=2009-03-01&rft.volume=15&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.issn=15289117&rft_id=info:doi/10.1097%2FPPO.0b013e3181a27018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-14 N1 - Date created - 2009-06-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells. AN - 67349468; 19348908 AB - The nitric oxide (NO) prodrug JS-K is shown to have anticancer activity. To profile the molecular events associated with the anticancer effects of JS-K, HL-60 leukemia cells were treated with JS-K and subjected to microarray and real-time RT-PCR analysis. JS-K induced concentration- and time-dependent gene expression changes in HL-60 cells corresponding to the cytolethality effects. The apoptotic genes (caspases, Bax, and TNF-alpha) were induced, and differentiation-related genes (CD14, ITGAM, and VIM) were increased. For acute phase protein genes, some were increased (TP53, JUN) while others were suppressed (c-myc, cyclin E). The expression of anti-angiogenesis genes THBS1 and CD36 and genes involved in tumor cell migration such as tissue inhibitors of metalloproteinases, were also increased by JS-K. Confocal analysis confirmed key gene changes at the protein levels. Thus, multiple molecular events are associated with JS-K effects in killing HL-60, which could be molecular targets for this novel anticancer NO prodrug. JF - Genomics AU - Liu, Jie AU - Malavya, Swati AU - Wang, Xueqian AU - Saavedra, Joseph E AU - Keefer, Larry K AU - Tokar, Erik AU - Qu, Wei AU - Waalkes, Michael P AU - Shami, Paul J AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC, USA. Liu6@niehs.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 32 EP - 38 VL - 94 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Azo Compounds KW - Neoplasm Proteins KW - O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate KW - Piperazines KW - Prodrugs KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Down-Regulation KW - HL-60 Cells KW - Prodrugs -- pharmacology KW - Humans KW - Neoplasm Proteins -- genetics KW - Up-Regulation KW - Leukemia, Myeloid -- genetics KW - Azo Compounds -- pharmacology KW - Leukemia, Myeloid -- pathology KW - Piperazines -- pharmacology KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Antineoplastic Agents -- pharmacology KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67349468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Immunology%2C+Immunotherapy&rft.atitle=Recognition+of+NY-ESO-1%2B+tumor+cells+by+engineered+lymphocytes+is+enhanced+by+improved+vector+design+and+epigenetic+modulation+of+tumor+antigen+expression&rft.au=Wargo%2C+Jennifer+A%3BRobbins%2C+Paul+F%3BLi%2C+Yong%3BZhao%2C+Yangbing%3BEl-Gamil%2C+Mona%3BCaragacianu%2C+Diana%3BZheng%2C+Zhili%3BHong%2C+Julie+A%3BDowney%2C+Stephanie%3BSchrump%2C+David+S%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Wargo&rft.aufirst=Jennifer&rft.date=2009-03-01&rft.volume=58&rft.issue=3&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Cancer+Immunology%2C+Immunotherapy&rft.issn=03407004&rft_id=info:doi/10.1007%2Fs00262-008-0562-x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-01 N1 - Date created - 2009-06-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Leuk Res. 2007 Oct;31(10):1403-11 [17445886] Cancer Sci. 2007 Sep;98(9):1491-7 [17596205] Bioorg Med Chem. 2008 Nov 15;16(22):9764-71 [18930407] Oncogene. 2009 Jan 29;28(4):619-24 [18978812] J Med Chem. 2000 Jan 27;43(2):261-9 [10649981] J Org Chem. 2001 May 4;66(9):3090-8 [11325274] Microvasc Res. 2003 Jan;65(1):9-17 [12535866] Annu Rev Pharmacol Toxicol. 2003;43:585-607 [12415121] Mol Cancer Ther. 2003 Apr;2(4):409-17 [12700285] J Cell Physiol. 2003 Dec;197(3):426-34 [14566972] Oncogene. 2003 Oct 20;22(47):7369-75 [14576844] Toxicol Sci. 2004 Feb;77(2):249-57 [14691202] Mol Cancer Ther. 2004 Jun;3(6):709-14 [15210857] J Cell Sci. 1992 Feb;101 ( Pt 2):395-401 [1352781] Blood. 1992 Oct 15;80(8):1880-4 [1382708] Leuk Res. 1995 Aug;19(8):527-33 [7658698] Leukemia. 1998 Sep;12(9):1461-6 [9737697] Methods Enzymol. 2005;401:287-307 [16399394] Mol Pharmacol. 2006 Feb;69(2):501-8 [16288082] Cancer Metastasis Rev. 2006 Mar;25(1):9-34 [16680569] Cancer Metastasis Rev. 2006 Mar;25(1):99-113 [16680576] J Med Chem. 2006 Jul 13;49(14):4356-66 [16821795] Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1329-37 [16910780] Leuk Res. 2006 Oct;30(10):1279-83 [16439016] Clin Cancer Res. 2007 Feb 1;13(3):795-8 [17289869] Blood. 2007 Jul 15;110(2):709-18 [17384201] Breast Cancer Res. 2008;10(3):R44 [18474097] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ygeno.2009.03.005 ER - TY - JOUR T1 - Sociodemographic predictors of transitions across stages of alcohol use, disorders, and remission in the National Comorbidity Survey Replication. AN - 67317645; 19486727 AB - Although much is known about risk factors for the initiation of alcohol use, abuse, and dependence, few population-based studies have examined the predictors of transitions across these stages. The aim of this study is to examine the sociodemographic predictors of transitions across 6 stages of alcohol use in the National Comorbidity Survey Replication, a nationally representative household survey of the US population. A lifetime history of alcohol use, regular use (at least 12 drinks in a year), Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition alcohol abuse and dependence with abuse was collected in 5692 National Comorbidity Survey Replication respondents using the World Health Organization Composite International Diagnostic Interview, Version 3.0. Lifetime prevalence estimates were 91.7% for lifetime alcohol use, 72.9% for regular use, 13.2% for abuse, and 5.4% for dependence with abuse. Male sex, young age, non-Hispanic white race/ethnicity, low education, student status, and never being married predicted the onset of alcohol use, the transition from use to regular use, and from regular use to abuse. An early age of onset of alcohol use also predicted the latter transition. The transition from abuse to dependence was associated with an early age of onset of regular alcohol use, being previously married, and student status. Remission was predicted by young age and a later age of onset of alcohol abuse. The reduced number and magnitude of factors associated with transitions to dependence and remission suggest qualitatively different risk factors at these stages relative to other stages of progression. Further knowledge is needed concerning the mechanisms underlying these differences to guide selective and indicated prevention programs. JF - Comprehensive psychiatry AU - Kalaydjian, Amanda AU - Swendsen, Joel AU - Chiu, Wai-Tat AU - Dierker, Lisa AU - Degenhardt, Louisa AU - Glantz, Meyer AU - Merikangas, Kathleen R AU - Sampson, Nancy AU - Kessler, Ronald AD - Intramural Research Program of the National Institutes of Health, National Institute of Mental Health, Bethesda, MD 20893, USA. kalaydjiana@mail.nih.gov PY - 2009 SP - 299 EP - 306 VL - 50 IS - 4 KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Age of Onset KW - Humans KW - Prognosis KW - Disease Progression KW - Alcohol Drinking -- epidemiology KW - Alcoholism -- psychology KW - Comorbidity KW - Alcoholism -- epidemiology KW - Risk Factors KW - Health Surveys KW - Adult KW - Alcohol Drinking -- psychology KW - Middle Aged KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Adolescent KW - United States -- epidemiology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Survival Analysis KW - Prevalence KW - Alcohol-Related Disorders -- psychology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67317645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+psychiatry&rft.atitle=Sociodemographic+predictors+of+transitions+across+stages+of+alcohol+use%2C+disorders%2C+and+remission+in+the+National+Comorbidity+Survey+Replication.&rft.au=Kalaydjian%2C+Amanda%3BSwendsen%2C+Joel%3BChiu%2C+Wai-Tat%3BDierker%2C+Lisa%3BDegenhardt%2C+Louisa%3BGlantz%2C+Meyer%3BMerikangas%2C+Kathleen+R%3BSampson%2C+Nancy%3BKessler%2C+Ronald&rft.aulast=Kalaydjian&rft.aufirst=Amanda&rft.date=2009-07-01&rft.volume=50&rft.issue=4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Comprehensive+psychiatry&rft.issn=1532-8384&rft_id=info:doi/10.1016%2Fj.comppsych.2008.09.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-13 N1 - Date created - 2009-06-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cultur Divers Ethnic Minor Psychol. 1999 May;5(2):134-46 [15605683] J Subst Abuse. 1997;9:103-10 [9494942] Addiction. 2005 Mar;100(3):281-92 [15733237] Addiction. 2005 May;100(5):652-61 [15847623] Arch Gen Psychiatry. 2005 Jun;62(6):593-602 [15939837] Int J Methods Psychiatr Res. 2005;14(3):119-29 [16389888] J Stud Alcohol. 2005 Nov;66(6):795-805 [16459941] Addiction. 2006 Jun;101(6):824-34 [16696626] Psychol Med. 2006 Jul;36(7):987-98 [16650344] Arch Pediatr Adolesc Med. 2006 Jul;160(7):739-46 [16818840] J Stud Alcohol. 2006 Nov;67(6):803-9 [17060996] Alcohol Clin Exp Res. 2006 Nov;30(11):1856-65 [17067349] Addiction. 2007 Feb;102(2):216-25 [17222275] Int J Methods Psychiatr Res. 2006;15(4):167-80 [17266013] Arch Gen Psychiatry. 2007 Jul;64(7):830-42 [17606817] Drug Alcohol Depend. 2007 Oct 8;90(2-3):210-23 [17481828] Int J Methods Psychiatr Res. 2007;16(3):111-23 [17703472] Alcohol Clin Exp Res. 2008 Apr;32(4):607-16 [18341650] Alcohol Clin Exp Res. 2000 Jun;24(6):914-23 [10888082] J Stud Alcohol. 2000 Nov;61(6):799-808 [11188485] J Abnorm Psychol. 2001 Aug;110(3):378-91 [11502081] J Subst Abuse. 2001;13(4):493-504 [11775078] Alcohol Clin Exp Res. 2002 Jul;26(7):1047-61 [12170115] J Stud Alcohol. 2003 Jan;64(1):23-31 [12608480] Int J Methods Psychiatr Res. 2004;13(2):60-8 [15297904] Int J Methods Psychiatr Res. 2004;13(2):69-92 [15297905] Int J Methods Psychiatr Res. 2004;13(2):93-121 [15297906] Alcohol Clin Exp Res. 2004 Aug;28(8):1153-60 [15318113] JAMA. 1990 Nov 21;264(19):2511-8 [2232018] Br J Addict. 1992 Dec;87(12):1725-30 [1490086] Arch Gen Psychiatry. 1994 Jan;51(1):8-19 [8279933] J Stud Alcohol. 1997 Sep;58(5):464-73 [9273910] J Stud Alcohol. 2004 Nov;65(6):782-93 [15700517] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.comppsych.2008.09.012 ER - TY - JOUR T1 - Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft. AN - 67313479; 19418039 AB - We measured serum C-peptide (at least 0.167 nmol/l) in 54 of 141 (38%) patients with chronic type 1 diabetes and sought factors that might differentiate those with detectable C-peptide from those without it. Finding no differences, and in view of the persistent anti-beta cell autoimmunity in such patients, we speculated that the immunosuppression (to weaken autoimmune attack) and euglycaemia accompanying transplant-based treatments of type 1 diabetes might promote recovery of native pancreatic beta cell function. We performed arginine stimulation tests in three islet transplant and four whole-pancreas transplant recipients, and measured stimulated C-peptide in select venous sampling sites. On the basis of each sampling site's C-peptide concentration and kinetics, we differentiated insulin secreted from the individual's native pancreatic beta cells and that secreted from allografted beta cells. Selective venous sampling demonstrated that despite long-standing type 1 diabetes, all seven beta cell allograft recipients displayed evidence that their native pancreas secreted C-peptide. Yet even if chronic immunosuppression coupled with near normal glycaemia did improve native pancreatic C-peptide production, the magnitude of the effect was quite small. Some native pancreatic beta cell function persists even years after disease onset in most type 1 diabetic patients. However, if prolonged euglycaemia plus anti-rejection immunosuppressive therapy improves native pancreatic insulin production, the effect in our participants was small. We may have underestimated pancreatic regenerative capacity by studying only a limited number of participants or by creating conditions (e.g. high circulating insulin concentrations or immunosuppressive agents toxic to beta cells) that impair beta cell function. JF - Diabetologia AU - Liu, E H AU - Digon, B J AU - Hirshberg, B AU - Chang, R AU - Wood, B J AU - Neeman, Z AU - Kam, A AU - Wesley, R A AU - Polly, S M AU - Hofmann, R M AU - Rother, K I AU - Harlan, D M AD - Diabetes Branch, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1369 EP - 1380 VL - 52 IS - 7 KW - Biomarkers KW - 0 KW - Blood Glucose KW - C-Peptide KW - Immunosuppressive Agents KW - Insulin KW - Index Medicus KW - Kidney Transplantation KW - Regeneration -- physiology KW - C-Peptide -- blood KW - Humans KW - Insulin -- blood KW - Portal Vein KW - Insulin -- secretion KW - Transplantation, Homologous KW - Pancreas Transplantation KW - C-Peptide -- secretion KW - Adult KW - Middle Aged KW - Chronic Disease KW - Hepatic Veins KW - Biomarkers -- blood KW - Female KW - Male KW - Diabetes Mellitus, Type 1 -- immunology KW - Blood Glucose -- metabolism KW - Islets of Langerhans Transplantation KW - Insulin-Secreting Cells -- secretion KW - Insulin-Secreting Cells -- metabolism KW - Insulin-Secreting Cells -- transplantation KW - Immunosuppressive Agents -- therapeutic use KW - Diabetes Mellitus, Type 1 -- surgery KW - Diabetes Mellitus, Type 1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67313479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Conditioning+in+2+2+Tables&rft.au=Proschan%2C+Michael+A%3BNason%2C+Martha&rft.aulast=Proschan&rft.aufirst=Michael&rft.date=2009-03-01&rft.volume=65&rft.issue=1&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/10.1111%2Fj.1541-0420.2008.01053.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-04 N1 - Date created - 2009-06-01 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00006505; ClinicalTrials.gov; NCT00246844 N1 - SuppNotes - Cited By: Diabetes Care. 2003 Mar;26(3):832-6 [12610045] Diabetes. 2003 Jan;52(1):102-10 [12502499] Stem Cells. 2003;21(4):377-88 [12832692] Ann Intern Med. 2003 Sep 2;139(5 Pt 1):346-51 [12965943] Diabetes Care. 2003 Nov;26(11):3191 [14578266] Ann Intern Med. 2003 Nov 18;139(10):W81 [14623642] Diabetes Care. 2003 Dec;26(12):3288-95 [14633816] J Intern Med. 2004 Mar;255(3):384-91 [14871463] Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2458-63 [14983031] Diabetes Care. 2004 May;27(5):1207-8 [15111548] Diabetes. 1978;27 Suppl 1:251-61 [75815] Diabetes. 1978;27 Suppl 1:262-4 [344117] Diabetologia. 1978 Sep;15(3):169-72 [359394] Diabetes. 1982 Aug;31(8 Pt 1):694-700 [6131002] Diabetologia. 1983 Mar;24(3):141-7 [6341142] Acta Med Scand Suppl. 1983;671:61-7 [6349267] Diabetes. 1984 Jun;33(6):516-21 [6373458] Behring Inst Mitt. 1984 Jul;(75):39-41 [6385953] Diabetologia. 1986 May;29(5):267-74 [3522324] Diabetologia. 1987 Oct;30(10):757-62 [3322901] Horm Metab Res. 1996 Jul;28(7):332-6 [8858379] Nat Genet. 1997 Mar;15(3):293-7 [9054945] Horm Metab Res. 1997 Oct;29(10):510-5 [9405979] Ann Intern Med. 1998 Apr 1;128(7):517-23 [9518395] Diabetes. 1998 Mar;47(3):324-30 [9519735] Diabetes Care. 1998 Jan;21(1):49-52 [9538970] Nature. 2005 May 12;435(7039):224-8 [15889096] Diabetes. 2005 Sep;54(9):2557-67 [16123343] Diabetologia. 2005 Nov;48(11):2221-8 [16205882] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18425-30 [16339897] Diabetologia. 2006 Jan;49(1):83-9 [16323002] Cell Cycle. 2006 Feb;5(3):234-7 [16410729] Diabetologia. 2006 Aug;49(8):1838-44 [16802132] Nature. 2006 Sep 21;443(7109):345-9 [16988714] Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16430-5 [17053071] Nat Biotechnol. 2006 Nov;24(11):1392-401 [17053790] Diabetes. 2006 Dec;55(12):3238-45 [17130466] Nat Immunol. 2007 Jan;8(1):25-30 [17179969] J Clin Invest. 2007 Jan;117(1):246-57 [17200721] Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2337-42 [17267595] Dev Cell. 2007 May;12(5):817-26 [17488631] Diabetes. 2008 Jun;57(6):1584-94 [18334605] PLoS One. 2009;4(3):e4827 [19287497] J Mol Endocrinol. 2000 Jun;24(3):297-302 [10828822] Diabetes. 2001 Feb;50 Suppl 1:S20-4 [11272192] J Clin Invest. 2001 Jul;108(1):63-72 [11435458] Diabetes. 2001 Dec;50(12):2700-8 [11723052] J Clin Endocrinol Metab. 2003 May;88(5):2300-8 [12727989] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00125-009-1342-7 ER - TY - JOUR T1 - Simultaneous quantification of buprenorphine, norbuprenorphine, buprenorphine-glucuronide and norbuprenorphine-glucuronide in human umbilical cord by liquid chromatography tandem mass spectrometry. AN - 67277418; 19406593 AB - A LCMS method was developed and validated for the simultaneous determination of buprenorphine (BUP), norbuprenorphine (NBUP), buprenorphine-glucuronide (BUP-Gluc) and norbuprenorphine-glucuronide (NBUP-Gluc) in human umbilical cord. Quantification was achieved by selected ion monitoring of precursor ions m/z 468.4 for BUP; 414.3 for NBUP; 644.4 for BUP-Gluc and 590 for NBUP-Gluc. BUP and NBUP were identified by MS(2), with m/z 396, 414 and 426 for BUP, and m/z 340, 364 and 382 for NBUP. Glucuronide conjugates were identified by MS(3) with m/z 396 and 414 for BUP-Gluc and m/z 340 and 382 for NBUP-Gluc. The assay was linear 1-50 ng/g. Intra-day, inter-day and total assay imprecision (%RSD) were 66.3%, and process efficiency >73.4%. Matrix effect ranged, in absolute value, from 3.7% to 7.4% (CV<21.8%, n=8). The method was selective with no endogenous or exogenous interferences from 41 compounds evaluated. Sensitivity was high with limits of detection of 0.8 ng/g. In order to prove method applicability, an authentic umbilical cord obtained from an opioid-dependent pregnant woman receiving BUP pharmacotherapy was analyzed. Interestingly, BUP was not detected but concentrations of the other metabolites were NBUP-Gluc 13.4 ng/g, BUP-Gluc 3.5 ng/g and NBUP 1.2 ng/g. JF - Forensic science international AU - Concheiro, Marta AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009/07/01/ PY - 2009 DA - 2009 Jul 01 SP - 144 EP - 151 VL - 188 IS - 1-3 KW - Glucuronides KW - 0 KW - Narcotic Antagonists KW - Buprenorphine KW - 40D3SCR4GZ KW - norbuprenorphine KW - 7E53B4O073 KW - Index Medicus KW - Humans KW - Chromatography, Liquid KW - Opioid-Related Disorders -- rehabilitation KW - Forensic Toxicology KW - Tandem Mass Spectrometry KW - Female KW - Pregnancy KW - Narcotic Antagonists -- analysis KW - Buprenorphine -- analysis KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Buprenorphine -- analogs & derivatives KW - Umbilical Cord -- chemistry KW - Glucuronides -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67277418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Forensic+science+international&rft.atitle=Simultaneous+quantification+of+buprenorphine%2C+norbuprenorphine%2C+buprenorphine-glucuronide+and+norbuprenorphine-glucuronide+in+human+umbilical+cord+by+liquid+chromatography+tandem+mass+spectrometry.&rft.au=Concheiro%2C+Marta%3BShakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Concheiro&rft.aufirst=Marta&rft.date=2009-07-01&rft.volume=188&rft.issue=1-3&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Forensic+science+international&rft.issn=1872-6283&rft_id=info:doi/10.1016%2Fj.forsciint.2009.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-13 N1 - Date created - 2009-05-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addiction. 2000 Aug;95(8):1141-4 [11092062] J Perinatol. 2008 Nov;28(11):750-3 [18596707] J Anal Toxicol. 2003 Mar;27(2):103-5 [12670004] J Pharm Biomed Anal. 2003 Aug 8;32(4-5):619-31 [12899952] J Anal Toxicol. 2003 Oct;27(7):464-70 [14607001] Forensic Sci Int. 2004 Jul 16;143(2-3):153-6 [15240036] Clin Chem. 1984 Feb;30(2):290-2 [6692538] J Anal Toxicol. 1993 Jan-Feb;17(1):62 [8429631] J Forensic Sci Soc. 1993 Jul-Sep;33(3):139-42 [8245814] J Anal Toxicol. 1993 Nov-Dec;17(7):443-4 [8309223] J Anal Toxicol. 1996 Oct;20(6):393-7 [8889674] J Forensic Sci. 1997 Jan;42(1):111-4 [8988582] J Anal Toxicol. 1997 Mar-Apr;21(2):97-104 [9083826] J Anal Toxicol. 1997 Mar-Apr;21(2):160-5 [9083835] J Anal Toxicol. 1997 Oct;21(6):406-14 [9323518] Drug Metab Dispos. 1998 Aug;26(8):818-21 [9698298] J Pediatr Nurs. 1998 Oct;13(5):307-16 [9798367] J Anal Toxicol. 1999 Oct;23(6):409-15 [10517544] J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jan 25;814(2):369-73 [15639461] J Mass Spectrom. 2005 Jan;40(1):70-4 [15637731] J Anal Toxicol. 2005 Jan-Feb;29(1):54-7 [15808014] Drug Alcohol Depend. 2005 Jul;79(1):1-10 [15943939] J Anal Toxicol. 2005 May-Jun;29(4):249-53 [15975254] Ther Drug Monit. 2005 Aug;27(4):526-30 [16044112] J Perinatol. 2006 Jan 1;26(1):11-4 [16281047] Rapid Commun Mass Spectrom. 2006;20(8):1257-65 [16550495] Drug Alcohol Depend. 2006 May 20;82(3):250-7 [16257138] J Anal Toxicol. 2006 Mar;30(2):115-9 [16620543] Ther Drug Monit. 2006 Apr;28(2):245-51 [16628138] J Mass Spectrom. 2006 May;41(5):633-40 [16541404] Pediatrics. 2006 Sep;118(3):1149-56 [16951010] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 1;850(1-2):538-43 [17141582] J Anal Toxicol. 2007 May;31(4):214-9 [17555645] Anal Bioanal Chem. 2007 Aug;388(7):1455-65 [17370066] Ther Drug Monit. 2007 Dec;29(6):711-34 [18043469] Anal Chem. 2008 Jan 1;80(1):246-52 [18044957] Clin Chem. 2007 Dec;53(12):2136-43 [17921260] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):107-14 [18243821] Talanta. 2008 Mar 15;75(1):198-204 [18371868] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 15;867(2):194-204 [18424195] J Mass Spectrom. 2008 Jul;43(7):974-9 [18563859] J Anal Toxicol. 2008 Sep;32(7):516-21 [18713521] Clin Chem. 2008 Sep;54(9):1519-27 [18635749] Anal Bioanal Chem. 2008 Nov;392(5):903-11 [18758763] Clin Pharmacol Ther. 2008 Nov;84(5):604-12 [18701886] J Chromatogr B Biomed Sci Appl. 2001 Apr 25;754(2):447-59 [11339288] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.forsciint.2009.04.005 ER - TY - JOUR T1 - Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices. AN - 67274037; 18068871 AB - Presenilin-1 (PS1) mutations cause many cases of early-onset inherited Alzheimer's disease, in part, by increasing the production of neurotoxic forms of amyloid beta-peptide (Abeta). However, Abeta-independent effects of mutant PS1 on neuronal Ca(2+) homeostasis and sensitivity to excitatory neurotransmitters have been reported. Here we show that cholinergic modulation of hippocampal synaptic plasticity is impaired in PS1 mutant knockin (PS1KI) mice. Whereas activation of muscarinic receptors enhances LTP at CA1 synapses of normal mice, it impairs LTP in PS1KI mice. Similarly, mutant PS1 impairs the ability of the cholinesterase inhibitor phenserine to enhance LTP. The NMDA current is decreased in CA1 neurons of PS1KI mice and is restored by intracellular Ca(2+)chelation. Similar alterations in acetylcholine and NMDA receptor-mediated components of synaptic plasticity are evident in 3xTgAD mice with PS1, amyloid precursor protein and tau mutations, suggesting that the adverse effects of mutant PS1 on synaptic plasticity can occur in the absence or presence of amyloid and tau pathologies. JF - Neurobiology of aging AU - Wang, Yue AU - Greig, Nigel H AU - Yu, Qian-sheng AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, Baltimore, MD 21224, USA. wangyu@grc.nia.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1061 EP - 1068 VL - 30 IS - 7 KW - Amyloid beta-Peptides KW - 0 KW - Cholinesterase Inhibitors KW - Presenilin-1 KW - Receptors, Muscarinic KW - Receptors, N-Methyl-D-Aspartate KW - tau Proteins KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Cholinesterase Inhibitors -- pharmacology KW - Long-Term Potentiation -- genetics KW - Animals KW - tau Proteins -- metabolism KW - Memory Disorders -- physiopathology KW - Basal Nucleus of Meynert -- physiopathology KW - Cholinergic Fibers -- pathology KW - Neural Pathways -- metabolism KW - Mice KW - Neural Pathways -- pathology KW - Mice, Transgenic KW - Memory Disorders -- metabolism KW - Cholinergic Fibers -- metabolism KW - Basal Nucleus of Meynert -- metabolism KW - Amyloid beta-Peptides -- metabolism KW - Synaptic Transmission -- genetics KW - Gene Knock-In Techniques KW - Mice, Inbred C57BL KW - Receptors, Muscarinic -- drug effects KW - Mutation -- genetics KW - Organ Culture Techniques KW - Male KW - Receptors, Muscarinic -- metabolism KW - Memory Disorders -- genetics KW - Acetylcholine -- metabolism KW - Neuronal Plasticity -- genetics KW - Alzheimer Disease -- physiopathology KW - Hippocampus -- metabolism KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Alzheimer Disease -- metabolism KW - Presenilin-1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67274037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+aging&rft.atitle=Presenilin-1+mutation+impairs+cholinergic+modulation+of+synaptic+plasticity+and+suppresses+NMDA+currents+in+hippocampus+slices.&rft.au=Wang%2C+Yue%3BGreig%2C+Nigel+H%3BYu%2C+Qian-sheng%3BMattson%2C+Mark+P&rft.aulast=Wang&rft.aufirst=Yue&rft.date=2009-07-01&rft.volume=30&rft.issue=7&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+aging&rft.issn=1558-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-21 N1 - Date created - 2009-05-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroscience. 2003;117(4):821-30 [12654335] J Biol Chem. 2003 Jan 24;278(4):2484-9 [12431992] ScientificWorldJournal. 2003 Jun 16;3:497-519 [12847300] Neuron. 2003 Jul 31;39(3):409-21 [12895417] Neuroscience. 2004;124(3):501-5 [14980721] Neuroscience. 2004;126(2):305-12 [15207348] Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9458-62 [15190179] Nature. 2004 Aug 5;430(7000):631-9 [15295589] Neuron. 2004 Sep 30;44(1):5-21 [15450156] Neurology. 2004 Oct 12;63(7):1155-62 [15477531] Science. 1988 Dec 23;242(4886):1694-7 [2904701] Neurosci Lett. 1990 Nov 13;119(2):207-10 [2280895] J Neurosci. 1993 Feb;13(2):674-84 [7678859] Trends Neurosci. 1997 Apr;20(4):154-9 [9106355] J Neurosci. 1997 Jun 1;17(11):4212-22 [9151738] J Med Chem. 1997 Aug 29;40(18):2895-901 [9288171] J Neurosci. 1997 Nov 1;17(21):8178-86 [9334393] J Physiol. 1998 Dec 1;513 ( Pt 2):467-75 [9806996] Nat Med. 1999 Jan;5(1):101-6 [9883847] J Neurochem. 1999 Feb;72(2):634-42 [9930735] J Neurochem. 1999 Mar;72(3):1030-9 [10037474] Neurobiol Dis. 1999 Feb;6(1):56-62 [10078973] Nat Neurosci. 1999 Mar;2(3):271-6 [10195221] Synapse. 1999 Sep 1;33(3):172-80 [10420165] Neuron. 2005 Mar 3;45(5):675-88 [15748844] Nat Med. 2005 May;11(5):556-61 [15834427] J Neurochem. 2005 Sep;94(6):1711-8 [16156741] J Neurosci. 2005 Nov 30;25(48):11194-200 [16319319] Learn Mem. 2005 Nov-Dec;12(6):594-600 [16287718] Annu Rev Med. 2006;57:513-33 [16409164] Exp Neurol. 2006 Feb;197(2):291-300 [16039651] J Physiol Paris. 2006 Mar-May;99(2-3):172-9 [16448808] J Neurosci. 2006 May 10;26(19):5180-9 [16687509] Exp Neurol. 2006 Jul;200(1):82-8 [16546171] Cell. 2006 Sep 8;126(5):981-93 [16959576] J Neurophysiol. 2006 Dec;96(6):3114-21 [17005622] Neuroscience. 2007 Jan 19;144(2):754-61 [17101232] Am J Hum Genet. 2006 Dec;79(6):1030-9 [17186461] Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):403-9 [17197420] Neurobiol Dis. 2007 Apr;26(1):212-20 [17306982] Neuron. 1999 Nov;24(3):701-13 [10595520] J Neurosci. 2000 Feb 15;20(4):1358-64 [10662826] Neurobiol Dis. 2000 Apr;7(2):119-26 [10783295] J Biol Chem. 2000 May 12;275(19):14440-5 [10748169] J Cell Biol. 2000 May 15;149(4):793-8 [10811821] J Biol Chem. 2000 Jun 16;275(24):18195-200 [10764737] Neuron. 2000 Sep;27(3):561-72 [11055438] J Neurochem. 2001 May;77(4):961-71 [11359861] Neuroreport. 2001 May 25;12(7):1377-84 [11388415] Nature. 2002 Apr 4;416(6880):535-9 [11932745] J Neurophysiol. 2002 Jul;88(1):249-55 [12091550] Science. 2002 Oct 25;298(5594):789-91 [12399581] Nat Rev Neurosci. 2002 Nov;3(11):862-72 [12415294] Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):635-41 [12740108] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multi-center trial of baclofen for abstinence initiation in severe cocaine-dependent individuals. AN - 67244919; 19414226 AB - Cocaine dependence is a major public health problem for which there is no FDA-approved pharmacological treatment. Baclofen is a GABA(B) receptor agonist that in preclinical and early pilot clinical trials has shown promise for the treatment of cocaine dependence. The purpose of this multi-site, double-blind study, was to compare the safety and efficacy of baclofen (60 mg/day) vs placebo in an 8-week treatment of individuals with severe cocaine dependence. The primary outcome measure was subjects' self-reported cocaine use substantiated by urine benzoylecgonine (BE). Analysis of the data did not show a significant difference between the groups treated with baclofen and placebo. The current results do not support a role for 60 mg baclofen in treating cocaine dependence in the population studied. The contrast of this result to earlier, preclinical and human pilot data with baclofen may reflect the trial's focus on severe cocaine-dependent users, and/or the need for a higher baclofen dose. Baclofen's potential as a relapse prevention agent was not tested by the current design, but may be a useful target for future studies. JF - Drug and alcohol dependence AU - Kahn, Roberta AU - Biswas, Kousick AU - Childress, Anna-Rose AU - Shoptaw, Steve AU - Fudala, Paul J AU - Gorgon, Liza AU - Montoya, Ivan AU - Collins, Joseph AU - McSherry, Frances AU - Li, Shou-Hua AU - Chiang, Nora AU - Alathari, Husam AU - Watson, Donnie AU - Liberto, Joseph AU - Beresford, Thomas AU - Stock, Christopher AU - Wallace, Christopher AU - Gruber, Valerie AU - Elkashef, Ahmed AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, 6001 Executive Blvd., Bethesda, MD 20892, USA. Y1 - 2009/07/01/ PY - 2009 DA - 2009 Jul 01 SP - 59 EP - 64 VL - 103 IS - 1-2 KW - GABA Agonists KW - 0 KW - Placebos KW - benzoylecgonine KW - 5353I8I6YS KW - Baclofen KW - H789N3FKE8 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Limbic System -- physiopathology KW - Educational Status KW - Double-Blind Method KW - Cocaine -- urine KW - Combined Modality Therapy KW - Dose-Response Relationship, Drug KW - Humans KW - GABA Agonists -- therapeutic use KW - Safety KW - Continental Population Groups KW - Employment KW - Counseling KW - Cocaine -- administration & dosage KW - Limbic System -- drug effects KW - Cocaine -- analogs & derivatives KW - Behavior Therapy KW - Adult KW - Middle Aged KW - Male KW - Female KW - Cocaine-Related Disorders -- drug therapy KW - Cocaine-Related Disorders -- rehabilitation KW - Baclofen -- therapeutic use KW - Cocaine-Related Disorders -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67244919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.atitle=Voriconazole-induced+phototoxicity+masquerading+as+chronic+graft-versus-host+disease+of+the+skin+in+allogeneic+hematopoietic+cell+transplant+recipients.&rft.au=Patel%2C+Asha+R%3BTurner%2C+Maria+L%3BBaird%2C+Kristin%3BGea-Banacloche%2C+Juan%3BMitchell%2C+Sandra%3BPavletic%2C+Steven+Z%3BWise%2C+Barbara%3BCowen%2C+Edward+W&rft.aulast=Patel&rft.aufirst=Asha&rft.date=2009-03-01&rft.volume=15&rft.issue=3&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.issn=1523-6536&rft_id=info:doi/10.1016%2Fj.bbmt.2008.12.491 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-16 N1 - Date created - 2009-05-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 2000 Feb;148(3):314-21 [10755745] Drug Alcohol Depend. 2009 Jul 1;103(1-2):30-6 [19398283] Alcohol Alcohol. 2002 Sep-Oct;37(5):478-84 [12217943] Alcohol Alcohol. 2002 Sep-Oct;37(5):495-8 [12217945] Neuropsychopharmacology. 2003 Mar;28(3):510-8 [12629530] Synapse. 2003 Oct;50(1):1-6 [12872287] J Clin Psychiatry. 2003 Dec;64(12):1440-8 [14728105] Psychopharmacology (Berl). 2004 Mar;172(2):179-86 [14610636] J Nerv Ment Dis. 1985 Jul;173(7):412-23 [4009158] Biometrics. 1986 Mar;42(1):121-30 [3719049] Brain Res Brain Res Rev. 1991 Sep-Dec;16(3):223-44 [1665095] Neuropsychopharmacology. 1996 Oct;15(4):417-23 [8887996] NIDA Res Monogr. 1997;175:253-64 [9467803] Neuropsychopharmacology. 1998 May;18(5):403-4 [9536455] Addict Behav. 1998 Jul-Aug;23(4):449-61 [9698974] Psychopharmacology (Berl). 1999 Apr;143(2):209-14 [10326784] Neurotox Res. 2004;6(5):403-14 [15545024] Psychopharmacology (Berl). 2005 Feb;177(4):409-17 [15630589] Alcohol Alcohol. 2005 Mar-Apr;40(2):147-50 [15596425] Neuropsychopharmacology. 2005 Nov;30(11):2065-72 [15841108] Neuropsychopharmacology. 2006 Aug;31(8):1814-21 [16407903] Alcohol Clin Exp Res. 2007 Jan;31(1):11-8 [17207096] Alcohol Alcohol. 2007 Mar-Apr;42(2):158-60 [17172256] Neuropharmacology. 2007 Jun;52(7):1555-62 [17451755] Drug Alcohol Depend. 2007 Jul 10;89(2-3):206-13 [17234367] Int J Eat Disord. 2007 Dec;40(8):687-91 [17647277] Lancet. 2007 Dec 8;370(9603):1915-22 [18068515] Neurochem Res. 2008 Mar;33(3):459-67 [17943439] Drug Alcohol Depend. 2008 Jun 1;95(3):284-7 [18374518] Psychopharmacology (Berl). 2002 Feb;160(1):49-55 [11862373] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.drugalcdep.2009.03.011 ER - TY - JOUR T1 - Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings. AN - 67235144; 18996050 AB - A scientific review panel for the US Food and Drug Administration (FDA) recently identified the need for more data on the health risk of mercury exposure from dental amalgam among susceptible populations. We evaluated impacts of low-level mercury exposure on renal function and neurobehavioral and neuropsychological performance among children. Dental histories for 403 children aged 7-11 years in five schools from Xuhui, Shanghai were checked by dentists. Of them, 198 with confirmed amalgam fillings were recruited (exposure group). Reference children (N=205) were those who never had dental amalgam treatment. In May 2004, each child provided a urine sample for measurements of total mercury, N-acetyl-beta-D-glucosaminidase activity, microalbumin, and creatinine (Cr). The Child Behavior Checklist, Eysenck Personality Questionnaire, and an intelligence screening test were administered. The geometric mean urinary mercury concentration was 1.6 microg/g Cr for children with and 1.4 microg/g Cr for children without amalgam fillings. No differences were found between children with and without fillings for either renal function biomarker, or on neurobehavioral, neuropsychological, or intelligence tests. Although urinary mercury concentration was slightly elevated among children with amalgam fillings, we found no evidence of adverse effects on the outcomes evaluated. These results agree with those from recent trials in developed countries. JF - International journal of hygiene and environmental health AU - Ye, Xibiao AU - Qian, Haojun AU - Xu, Peicheng AU - Zhu, Lin AU - Longnecker, Matthew P AU - Fu, Hua AD - Department of Preventive Medicine, School of Public Health, Fudan University, PO Box 248, 138 Yixueyuan Road, Shanghai 20032, China. yex2@niehs.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 378 EP - 386 VL - 212 IS - 4 KW - Biomarkers KW - 0 KW - Dental Amalgam KW - 8049-85-2 KW - Creatinine KW - AYI8EX34EU KW - Acetylglucosaminidase KW - EC 3.2.1.52 KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - Intelligence -- drug effects KW - Albuminuria KW - Creatinine -- urine KW - Dose-Response Relationship, Drug KW - Humans KW - Child Behavior -- drug effects KW - Acetylglucosaminidase -- urine KW - Biomarkers -- urine KW - Child KW - Personality -- drug effects KW - China KW - Female KW - Male KW - Neurotoxicity Syndromes -- urine KW - Mercury -- urine KW - Mercury -- adverse effects KW - Neurotoxicity Syndromes -- etiology KW - Kidney -- drug effects KW - Dental Amalgam -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67235144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=GRL-02031%2C+a+Novel+Nonpeptidic+Protease+Inhibitor+%28PI%29+Containing+a+Stereochemically+Defined+Fused+Cyclopentanyltetrahydrofuran+Potent+against+Multi-PI-Resistant+Human+Immunodeficiency+Virus+Type+1+In+Vitro&rft.au=Koh%2C+Yasuhiro%3BDas%2C+Debananda%3BLeschenko%2C+Sofiya%3BNakata%2C+Hirotomo%3BOgata-Aoki%2C+Hiromi%3BAmano%2C+Masayuki%3BNakayama%2C+Maki%3BGhosh%2C+Arun+K%3BMitsuya%2C+Hiroaki&rft.aulast=Koh&rft.aufirst=Yasuhiro&rft.date=2009-03-01&rft.volume=53&rft.issue=3&rft.spage=997&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00689-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2009-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Chim Acta. 2000 Jul;297(1-2):173-82 [10841919] Crit Rev Toxicol. 2006 Sep;36(8):609-62 [16973445] J Toxicol Clin Toxicol. 2001;39(7):701-5 [11778667] J Toxicol Environ Health A. 2003 May 9;66(9):783-98 [12746126] Toxicol Appl Pharmacol. 2004 Jul 15;198(2):209-30 [15236954] Clin Chim Acta. 1972 Oct;41:209-17 [4645233] Am J Physiol. 1990 Apr;258(4 Pt 2):R939-45 [2331037] Br Dent J. 1997 Jun 28;182(12):455-9 [9231518] Environ Health Perspect. 2006 Apr;114(4):584-90 [16581550] JAMA. 2006 Apr 19;295(15):1775-83 [16622139] JAMA. 2006 Apr 19;295(15):1784-92 [16622140] Int J Hyg Environ Health. 2006 Jul;209(4):309-16 [16448848] Am J Kidney Dis. 2007 Feb;49(2 Suppl 2):S12-154 [17276798] Environ Health Perspect. 2007 Mar;115(3):440-6 [17431496] Public Health Rep. 2007 Sep-Oct;122(5):657-63 [17877313] Environ Health Perspect. 2007 Oct;115(10):1527-31 [17938746] Environ Health Perspect. 2008 Mar;116(3):394-9 [18335109] Environ Res. 2008 May;107(1):79-88 [17961541] J Dent Res. 2008 May;87(5):470-4 [18434579] Pediatr Rev. 2000 Aug;21(8):265-71 [10922023] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijheh.2008.09.004 ER - TY - JOUR T1 - Use of rituximab for refractory cytopenias associated with autoimmune lymphoproliferative syndrome (ALPS). AN - 67128369; 19214977 AB - ALPS is a disorder of apoptosis resulting in accumulation of autoreactive lymphocytes, leading to marked lymphadenopathy, hepatosplenomegaly, and multilineage cytopenias due to splenic sequestration and/or autoimmune destruction often presenting in childhood. We summarize our experience of rituximab use during the last 8 years in 12 patients, 9 children, and 3 adults, out of 259 individuals with ALPS, belonging to 166 families currently enrolled in studies at the National Institutes of Health. Refractory immune thrombocytopenia (platelet count <20,000) in nine patients and autoimmune hemolytic anemia (AIHA) in three patients led to treatment with rituximab. Among them, seven patients had undergone prior surgical splenectomy; three had significant splenomegaly; and two had no palpable spleen. In seven out of nine patients with ALPS and thrombocytopenia, rituximab therapy led to median response duration of 21 months (range 14-36 months). In contrast, none of the three children treated with rituximab for AIHA responded. Noted toxicities included profound and prolonged hypogammaglobulinemia in three patients requiring replacement IVIG, total absence of antibody response to polysaccharide vaccines lasting up to 4 years after rituximab infusions in one patient and prolonged neutropenia in one patient. Toxicities including hypogammaglobulinemia and neutropenia constitute an additional infection risk burden, especially in asplenic individuals, and may warrant avoidance of rituximab until other immunosuppressive medication options are exhausted. Long-term follow-up of ALPS patients with cytopenias after any treatment is necessary to determine relative risks and benefits. (c) 2009 Wiley-Liss, Inc. JF - Pediatric blood & cancer AU - Rao, V Koneti AU - Price, Susan AU - Perkins, Katie AU - Aldridge, Patricia AU - Tretler, Jean AU - Davis, Joie AU - Dale, Janet K AU - Gill, Fred AU - Hartman, Kip R AU - Stork, Linda C AU - Gnarra, David J AU - Krishnamurti, Lakshmanan AU - Newburger, Peter E AU - Puck, Jennifer AU - Fleisher, Thomas AD - Laboratory of Clinical Infectious Diseases, NIAID, and Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1888, USA. krao@niaid.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 847 EP - 852 VL - 52 IS - 7 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Murine-Derived KW - Immunosuppressive Agents KW - Rituximab KW - 4F4X42SYQ6 KW - Index Medicus KW - Infant KW - Young Adult KW - Humans KW - Adult KW - Middle Aged KW - Drug Resistance, Neoplasm KW - Child KW - Adolescent KW - Child, Preschool KW - Lymphoproliferative Disorders -- drug therapy KW - Thrombocytopenia -- drug therapy KW - Autoimmune Diseases -- drug therapy KW - Anemia, Hemolytic, Autoimmune -- drug therapy KW - Lymphoproliferative Disorders -- immunology KW - Immunosuppressive Agents -- therapeutic use KW - Anemia, Hemolytic, Autoimmune -- immunology KW - Autoimmune Diseases -- immunology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67128369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+blood+%26+cancer&rft.atitle=Use+of+rituximab+for+refractory+cytopenias+associated+with+autoimmune+lymphoproliferative+syndrome+%28ALPS%29.&rft.au=Rao%2C+V+Koneti%3BPrice%2C+Susan%3BPerkins%2C+Katie%3BAldridge%2C+Patricia%3BTretler%2C+Jean%3BDavis%2C+Joie%3BDale%2C+Janet+K%3BGill%2C+Fred%3BHartman%2C+Kip+R%3BStork%2C+Linda+C%3BGnarra%2C+David+J%3BKrishnamurti%2C+Lakshmanan%3BNewburger%2C+Peter+E%3BPuck%2C+Jennifer%3BFleisher%2C+Thomas&rft.aulast=Rao&rft.aufirst=V&rft.date=2009-07-01&rft.volume=52&rft.issue=7&rft.spage=847&rft.isbn=&rft.btitle=&rft.title=Pediatric+blood+%26+cancer&rft.issn=1545-5017&rft_id=info:doi/10.1002%2Fpbc.21965 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-05 N1 - Date created - 2009-04-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Leuk Lymphoma. 2001 May;41(5-6):501-11 [11378568] Blood. 2001 Jul 1;98(1):194-200 [11418480] Blood. 2001 Aug 15;98(4):952-7 [11493438] Blood. 2001 Oct 15;98(8):2466-73 [11588044] Br J Haematol. 2002 Apr;117(1):176-88 [11918552] Br J Haematol. 2002 Sep;118(4):1078-81 [12199788] Nature. 2002 Sep 26;419(6905):395-9 [12353035] Blood. 2003 May 15;101(10):3857-61 [12531800] Curr Opin Rheumatol. 2003 Jul;15(4):417-21 [12819469] N Engl J Med. 2004 Sep 30;351(14):1409-18 [15459302] J Pediatr. 1967 Jun;70(6):891-9 [4165068] J Clin Invest. 1992 Aug;90(2):334-41 [1386609] Science. 1995 Jun 2;268(5215):1347-9 [7539157] Cell. 1995 Jun 16;81(6):935-46 [7540117] Blood. 1997 Feb 15;89(4):1341-8 [9028957] Am J Pathol. 1998 Nov;153(5):1541-50 [9811346] Ann Intern Med. 1999 Apr 6;130(7):591-601 [10189330] Am J Hum Genet. 1999 Apr;64(4):1002-14 [10090885] Br J Haematol. 2005 May;129(4):534-8 [15877736] Hum Genet. 2006 Apr;119(3):284-94 [16446975] Blood. 2006 Apr 1;107(7):2639-42 [16352811] Blood. 2006 Sep 15;108(6):1965-71 [16757690] J Pediatr Hematol Oncol. 2006 Dec;28(12):824-6 [17164652] J Pediatr. 2007 Apr;150(4):338-44, 344.e1 [17382107] Br J Haematol. 2007 May;137(4):349-54 [17456057] Proc Natl Acad Sci U S A. 2007 May 22;104(21):8953-8 [17517660] BMC Med Genet. 2007;8:41 [17605793] Eur J Haematol. 2007 Oct;79(4):363-6 [17725802] Arthritis Rheum. 2007 Sep;56(9):3044-56 [17763423] Am J Hematol. 2007 Dec;82(12):1049-55 [17674358] Blood. 2008 Jan 15;111(2):705-14 [17925488] Br J Haematol. 2008 Apr;141(2):149-69 [18318765] Pathology. 2008 Apr;40(3):288-94 [18428049] Blood. 2008 Jul 15;112(2):277-86 [18319398] Pediatr Blood Cancer. 2009 Feb;52(2):259-62 [18937333] Exp Hematol. 2009 Apr;37(4):487-94 [19217201] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pbc.21965 ER - TY - JOUR T1 - Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors. AN - 67122420; 19014961 AB - Thyroid hormone (T3) is critical in growth, development, differentiation, and maintenance of metabolic homeostasis. Recent studies suggest that thyroid hormone receptors (TRs) not only mediate the biological activities of T3 via nucleus-initiated transcription, but also could act via nongenomic pathways. The striking phenotype of thyroid cancer exhibited by a knockin mutant mouse that harbors a dominant negative TRbeta mutant (TRbeta(PV/PV) mouse) allows the elucidation of novel oncogenic activity of a TRbeta mutant (PV) via extra-nuclear actions. PV physically interacts with the regulatory p85alpha subunit of phosphatidylinositol 3-kinase (PI3K) to activate the downstream AKT-mammalian target of rapamycin (mTOR) and p70(S6K) and PI3K-integrin-linked kinase-matrix metalloproteinase-2 signaling pathways. The PV-mediated PI3K activation results in increased cell proliferation, motility, migration, and metastasis. Remarkably, a nuclear receptor corepressor (NCoR) was found to regulate the PV-activated PI3K signaling by competing with PV for binding to the C-terminal SH2 domain of p85alpha. Over-expression of NCoR in thyroid tumor cells of TRbeta(PV/PV) mice reduces AKT-mTOR-p70(S6K) signaling. Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells leads to over-activated PI3K-AKT signaling to increase cell proliferation and motility. Furthermore, NCoR protein levels are significantly lower in thyroid tumor cells than in wild type thyrocytes, allowing more effective binding of PV to p85alpha to activate PI3K signaling, thereby contributing to tumor progression. Thus, PV, an apo-TRbeta, could act via direct protein-protein interaction to mediate critical oncogenic actions. These studies also uncovered a novel extra-nuclear role of NCoR in modulating the nongenomic actions of a mutated TRbeta in controlling thyroid carcinogenesis. JF - Steroids AU - Furuya, Fumihiko AU - Lu, Changxue AU - Guigon, Celine J AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 628 EP - 634 VL - 74 IS - 7 SN - 0039-128X, 0039-128X KW - Receptors, Thyroid Hormone KW - 0 KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Index Medicus KW - Animals KW - Thyroid Neoplasms -- metabolism KW - Humans KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Receptors, Thyroid Hormone -- physiology KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67122420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Steroids&rft.atitle=Nongenomic+activation+of+phosphatidylinositol+3-kinase+signaling+by+thyroid+hormone+receptors.&rft.au=Furuya%2C+Fumihiko%3BLu%2C+Changxue%3BGuigon%2C+Celine+J%3BCheng%2C+Sheue-Yann&rft.aulast=Furuya&rft.aufirst=Fumihiko&rft.date=2009-07-01&rft.volume=74&rft.issue=7&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Steroids&rft.issn=0039128X&rft_id=info:doi/10.1016%2Fj.steroids.2008.10.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-13 N1 - Date created - 2009-04-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2005 Jan;19(1):102-12 [15388791] Genes Dev. 1999 May 15;13(10):1329-41 [10346821] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1780-5 [16446424] Mol Cell Endocrinol. 2006 Feb 26;246(1-2):121-7 [16442701] Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5197-201 [16549781] J Biol Chem. 2006 Jul 28;281(30):20666-72 [16717100] Mol Endocrinol. 2006 Sep;20(9):1996-2009 [16645038] Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14104-9 [16966610] J Mol Endocrinol. 2007 Feb;38(1-2):221-33 [17293442] J Biol Chem. 2007 Aug 3;282(31):22278-88 [17535799] Mol Cell Biol. 2007 Sep;27(17):6116-26 [17606624] Mol Cell. 2007 Sep 7;27(5):691-700 [17803935] Carcinogenesis. 2007 Dec;28(12):2451-8 [17660507] J Biol Chem. 2008 Mar 14;283(11):7109-16 [18184651] Curr Cancer Drug Targets. 2008 May;8(3):187-98 [18473732] J Clin Endocrinol Metab. 2008 Aug;93(8):3106-16 [18492751] Mol Cell Endocrinol. 2000 Jan 25;159(1-2):109-24 [10687857] Thyroid. 2000 Jan;10(1):41-52 [10691312] Mol Cell Biol Res Commun. 1999 May;1(2):153-7 [10356365] Nature. 2000 Sep 28;407(6803):538-41 [11029009] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15095-100 [11734632] Rev Endocr Metab Disord. 2000 Jan;1(1-2):9-18 [11704997] J Biol Chem. 2001 Jul 6;276(27):24466-72 [11313349] Mol Endocrinol. 2002 Sep;16(9):2077-92 [12198244] Thyroid. 2002 Nov;12(11):963-9 [12490073] Cancer Metastasis Rev. 2003 Dec;22(4):375-84 [12884912] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2076-81 [14764897] Mol Cell Endocrinol. 2003 Dec 31;213(1):1-11 [15062569] Cancer Treat Res. 2004;119:59-75 [15164873] J Clin Endocrinol Metab. 2004 Jul;89(7):3114-6 [15240579] Mol Endocrinol. 2004 Nov;18(11):2660-71 [15272054] Mol Endocrinol. 1991 Apr;5(4):485-92 [1922081] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] Mol Endocrinol. 1992 Feb;6(2):248-58 [1569968] Biochem J. 1998 Aug 1;333 ( Pt 3):471-90 [9677303] J Cell Physiol. 2006 Feb;206(2):309-21 [16021636] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.steroids.2008.10.009 ER - TY - JOUR T1 - Life After Cancer in India: Coping with Side Effects and Cancer Pain AN - 61427142; 200907549 AB - The article aims to understand the coping strategies of postsurgery head and neck cancer patients in Mumbai, India. A descriptive research design with a sample of 80 patients suffering from head and neck cancer was selected to analyze their coping strategies in relation to sociodemographic profile and illness characteristics. The findings of the study highlighted that the spiritual methods of coping (such as prayer and meditation, adopting a positive attitude) were the most frequently used mainstream coping strategy, apart from other traditional methods (such as taking medications, indulging in exercise and activities to divert one's attention, etc.) of coping. The findings of the study help to broaden the understanding of various psychosocial aspects faced by the patient in India and provide progressive recommendations to improve the quality of life of the patient suffering from cancer. Adapted from the source document. JF - Journal of Psychosocial Oncology AU - Jagannathan, A AU - Juvva, S AD - National Institute of Mental Health and Neurosciences, Koramangala, Bangalore, India Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 344 EP - 360 PB - Taylor & Francis, Philadelphia PA VL - 27 IS - 3 SN - 0734-7332, 0734-7332 KW - Religiosity KW - Surgery KW - Psychosocial Factors KW - Pain KW - Coping KW - Cancer KW - India KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61427142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosocial+Oncology&rft.atitle=Life+After+Cancer+in+India%3A+Coping+with+Side+Effects+and+Cancer+Pain&rft.au=Jagannathan%2C+A%3BJuvva%2C+S&rft.aulast=Jagannathan&rft.aufirst=A&rft.date=2009-07-01&rft.volume=27&rft.issue=3&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosocial+Oncology&rft.issn=07347332&rft_id=info:doi/10.1080%2F07347330902979150 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 37 N1 - Last updated - 2016-09-28 N1 - CODEN - JPONED N1 - SubjectsTermNotLitGenreText - Coping; Cancer; Pain; India; Surgery; Religiosity; Psychosocial Factors DO - http://dx.doi.org/10.1080/07347330902979150 ER - TY - JOUR T1 - When Scientists Deceive: Applying the Federal Regulations AN - 58819320; 2008-331869 AB - Deception is a useful methodological device for studying attitudes and behavior, but deceptive studies fail to fulfill the informed consent requirements in the U.S. federal regulations. This means that before they can be approved by Institutional Review Boards, they must satisfy the four regulatory conditions for a waiver or alteration of these requirements. To illustrate our interpretation, we apply the conditions to a recent study that used deception to show that subjects judged the same wine as more enjoyable when they believed it had a higher price. Adapted from the source document. JF - The Journal of Law, Medicine & Ethics AU - O'Neil, Collin C AU - Miller, Franklin G AD - Postdoctoral Fellow in the Department of Bioethics at the National Institutes of Health Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 344 EP - 350 PB - Wiley-Blackwell, UK VL - 37 IS - 2 SN - 1073-1105, 1073-1105 KW - Science and technology policy - Scientists, engineers, and technical workers KW - Law and ethics - Commercial law KW - Administration of justice - Crime and criminals KW - Economic conditions and policy - Economic policy, planning, and development KW - Law and ethics - Law and jurisprudence KW - Government - Forms of government KW - Law and ethics - Health law KW - United States KW - Informed consent KW - Federal government KW - Scientists KW - Fraud KW - Regulation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58819320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.atitle=When+Scientists+Deceive%3A+Applying+the+Federal+Regulations&rft.au=O%27Neil%2C+Collin+C%3BMiller%2C+Franklin+G&rft.aulast=O%27Neil&rft.aufirst=Collin&rft.date=2009-07-01&rft.volume=37&rft.issue=2&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.issn=10731105&rft_id=info:doi/10.1111%2Fj.1748-720X.2009.00377.x LA - English DB - PAIS Index N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Scientists; Fraud; Regulation; Federal government; Informed consent; United States DO - http://dx.doi.org/10.1111/j.1748-720X.2009.00377.x ER - TY - JOUR T1 - Research article: Colorectal Cancer Screening by Primary Care Physicians: Recommendations and Practices, 2006-2007 AN - 57309043; 200922684 AB - Primary care physicians (hereafter, physicians) play a critical role in the delivery of colorectal cancer (CRC) screening in the U.S. This study describes the CRC screening recommendations and practices of U.S. physicians and compares them to findings from a 1999-2000 national provider survey. Methods Data from 1266 physicians responding to the 2006-2007 National Survey of Primary Care Physicians' Recommendations and Practices for Breast, Cervical, Colorectal, and Lung Cancer Screening (cooperation rate=75%) were analyzed in 2008. Descriptive statistics were used to examine physicians' CRC screening recommendations and practices as well as the office systems used to support screening activities. Sample weights were applied in the analyses to obtain national estimates. Results Ninety-five percent of physicians routinely recommend screening colonoscopy to asymptomatic, average-risk patients; 80% recommend fecal occult blood testing (FOBT). Only a minority recommend sigmoidoscopy, double-contrast barium enema, computed tomographic colonography, or fecal DNA testing. Fifty-six percent recommend two screening modalities; 17% recommend one. Nearly all physicians who recommend endoscopy refer their patients for the procedure. Four percent perform sigmoidoscopy, a 25-percentage-point decline from 1999-2000. Although 61% of physicians reported that their practice had guidelines for CRC screening, only 30% use provider reminders; 15% use patient reminders. Conclusions Physicians' CRC screening recommendations and practices have changed substantially since 1999-2000. Colonoscopy is now the most frequently recommended test. Most physicians do not recommend the full menu of test options prescribed in national guidelines. Few perform sigmoidoscopy. Office systems to support CRC screening are lacking in many physicians' practices. Given ongoing changes in CRC screening technologies and guidelines, the continued monitoring of physicians' CRC screening recommendations and practices is imperative. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Klabunde, Carrie N AU - Lanier, David AU - Nadel, Marion R AU - McLeod, Caroline AU - Yuan, Gigi AU - Vernon, Sally W AD - Health Services and Economics Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 8 EP - 16 PB - Elsevier Science, New York NY VL - 37 IS - 1 SN - 0749-3797, 0749-3797 KW - Screening KW - Reminders KW - Sigmoidoscopy KW - Doctors KW - Colorectal cancer KW - Primary health care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57309043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Research+article%3A+Colorectal+Cancer+Screening+by+Primary+Care+Physicians%3A+Recommendations+and+Practices%2C+2006-2007&rft.au=Klabunde%2C+Carrie+N%3BLanier%2C+David%3BNadel%2C+Marion+R%3BMcLeod%2C+Caroline%3BYuan%2C+Gigi%3BVernon%2C+Sally+W&rft.aulast=Klabunde&rft.aufirst=Carrie&rft.date=2009-07-01&rft.volume=37&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2009.03.008 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Doctors; Screening; Colorectal cancer; Primary health care; Sigmoidoscopy; Reminders DO - http://dx.doi.org/10.1016/j.amepre.2009.03.008 ER - TY - JOUR T1 - Disordered-Eating Attitudes in Relation to Bone Mineral Density and Markers of Bone Turnover in Overweight Adolescents AN - 57307450; 200923718 AB - Purpose To examine the relationships between cognitive eating restraint and both bone mineral density (BMD) and markers of bone turnover in overweight adolescents. Methods One hundred thirty-seven overweight (BMI 39.1 +/- 6.8 kg/m2) African American and Caucasian adolescent (age = 14.4 +/- 1.4 years) girls (66.4%) and boys were administered the Eating Disorder Examination (EDE) interview and Eating Inventory (EI) questionnaire and underwent dual energy X-ray absorptiometry (DXA) to measure total lumbar spine BMD. Markers of bone formation (serum bone specific alkaline phosphatase and osteocalcin), bone resorption (24-hour urine N-telopeptides), and stress (urine free cortisol) were measured. Results After accounting for the contribution of demographics, height, weight, serum 25-hydroxyvitamin D, and depressive symptoms, adolescents' weight concern, as assessed by interview, was a significant contributor to the model of urine free cortisol (beta = .30, p < .05). Shape concern, as also assessed by interview, was significantly associated with lumbar spine bone mineral density (beta = -.15, p < .05). Dietary restraint was not a significant predictor in any of these models. Conclusions These findings suggest that among severely overweight adolescents, dissatisfaction with shape and weight may be salient stressors. Future research is required to illuminate the relationship between bone health and disordered-eating attitudes in overweight adolescents. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Schvey, Natasha A AU - Tanofsky-Kraff, Marian AU - Yanoff, Lisa B AU - Checchi, Jenna M AU - Shomaker, Lauren B AU - Brady, Sheila AU - Savastano, David M AU - Ranzenhofer, Lisa M AU - Yanovski, Susan Z AU - Reynolds, James C AU - Yanovski, Jack A AD - Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), DHHS, Rockville, Maryland Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 33 EP - 39 PB - Elsevier, New York NY VL - 45 IS - 1 SN - 1054-139X, 1054-139X KW - Adolescents Bone turnover Bone mineral density Disordered-eating attitudes Overweight Cortisol KW - Obesity KW - Bone mineral density KW - Bones KW - Urine KW - Cortisol KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57307450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Disordered-Eating+Attitudes+in+Relation+to+Bone+Mineral+Density+and+Markers+of+Bone+Turnover+in+Overweight+Adolescents&rft.au=Schvey%2C+Natasha+A%3BTanofsky-Kraff%2C+Marian%3BYanoff%2C+Lisa+B%3BChecchi%2C+Jenna+M%3BShomaker%2C+Lauren+B%3BBrady%2C+Sheila%3BSavastano%2C+David+M%3BRanzenhofer%2C+Lisa+M%3BYanovski%2C+Susan+Z%3BReynolds%2C+James+C%3BYanovski%2C+Jack+A&rft.aulast=Schvey&rft.aufirst=Natasha&rft.date=2009-07-01&rft.volume=45&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2008.12.020 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Bones; Adolescents; Obesity; Bone mineral density; Urine; Cortisol DO - http://dx.doi.org/10.1016/j.jadohealth.2008.12.020 ER - TY - JOUR T1 - Magnitude of and Trends in Alcohol-Related Mortality and Morbidity Among U.S. College Students Ages 18-24, 1998-2005 AN - 57304337; 200922408 AB - Objective: The aim of this study was to estimate, among college students ages 18-24, the numbers of alcohol-related unintentional injury deaths and other problems over the period from 1998 through 2005. Method: The analysis integrated data on 18- to 24-year-olds and college students from each of the following data sources: the National Highway Traffic Safety Administration Fatality Analysis Reporting System, Centers for Disease Control and Prevention Injury Mortality Data, National Coroner Studies, census and college enrollment data, the National Household Survey on Drug Use and Health, and the College Alcohol Study. Results: Among college students ages 18-24, alcohol-related unintentional injury deaths increased 3% per 100,000 from 1,440 in 1998 to 1,825 in 2005. From 1999 to 2005, the proportions of college students ages 18-24 who reported consuming five or more drinks on at least one occasion in the past month increased from 41.7% to 44.7%, and the proportions who drove under the influence of alcohol in the past year increased from 26.5% to 28.9%-7% and 9% proportional increases, respectively. The increases occurred among college students ages 21-24, not 18-20. In 2001, 599,000 (10.5%) full-time 4-year college students were injured because of drinking, 696,000 (12%) were hit or assaulted by another drinking college student, and 97,000 (2%) ere victims of alcohol-related sexual assault or date rape. A 2005 follow-up of students in schools with the highest proportions of heavy drinkers found no significant changes in the proportions experiencing these events. Conclusions: The persistence of college drinking problems underscores an urgent need to implement prevention and counseling approaches identified through research to reduce alcohol-related harms among college students and other young adults. (J. Stud. Alcohol Drugs, Supplement No. 16: 12-20, 2009). Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Hingson, Ralph W AU - Zha, Wenxing AU - Weitzman, Elissa R AD - Division of Epidemiology and Prevention Research, National Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Room 2077, Bethesda, Maryland 20892-9304 rhingson@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 12 EP - 20 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 70 IS - supplement 16 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - Prevention KW - Alcohol related problems KW - Alcohol related KW - Morbidity-Mortality KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57304337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=Using+the+RE-AIM+Framework+to+Evaluate+the+Statewide+Dissemination+of+a+School-Based+Physical+Activity+and+Nutrition+Curriculum%3A+%22Exercise+Your+Options%22&rft.au=Dunton%2C+Genevieve+F%3BLagloire%2C+Renee%3BRobertson%2C+Trina&rft.aulast=Dunton&rft.aufirst=Genevieve&rft.date=2009-03-01&rft.volume=23&rft.issue=4&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Undergraduate students; Alcohol consumption; Alcohol related problems; Prevention; Alcohol related; Morbidity-Mortality ER - TY - JOUR T1 - An Evaluation of College Online Alcohol-Policy Information: 2007 Compared With 2002 AN - 57303229; 200922016 AB - Objective: To receive federal funds, colleges and universities are required to provide information to students about their alcohol policies as part of their alcohol-abuse prevention efforts. This study investigated whether and how the availability and completeness of alcohol-policy information on college Web sites changed between 2002 and 2007. Method: The Web sites of the top 52 national universities listed in the 2002 rankings of U.S. News and World Report, which were reviewed for alcohol-policy information in 2002, were reviewed again in 2007 using the same Web search methodology. Results: Much more information regarding college alcohol policies was available on the Web sites of the 52 universities in 2007 than in 2002. Substantial increases were seen in the areas of (1) rules, restrictions, requirements; and (2) consequences for infractions, especially for student groups. In addition, information on university Web sites regarding their alcohol policies was easier to access in 2007 than in 2002. Conclusions: These findings indicate that colleges have made online alcohol-policy information more available and accessible to their students and other interested parties, including parents. This may reflect a greater engagement of colleges and universities in the issue of drinking on campus in general. (J. Stud. Alcohol Drugs, Supplement No. 16: 28-33, 2009). Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Faden, Vivian B AU - Corey, Kristin AU - Baskin, Marcy AD - Division of Epidemiology and Prevention Research, National Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Room 2087, Bethesda, Maryland 20892-9304 vfaden@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 28 EP - 33 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 70 IS - supplement 16 SN - 1937-1888, 1937-1888 KW - Web sites KW - Funds KW - Gender stereotypes KW - Parents KW - News KW - Internet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57303229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=An+Evaluation+of+College+Online+Alcohol-Policy+Information%3A+2007+Compared+With+2002&rft.au=Faden%2C+Vivian+B%3BCorey%2C+Kristin%3BBaskin%2C+Marcy&rft.aulast=Faden&rft.aufirst=Vivian&rft.date=2009-07-01&rft.volume=70&rft.issue=supplement+16&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Web sites; Internet; News; Gender stereotypes; Parents; Funds ER - TY - JOUR T1 - Brief report: Race/Ethnicity and the Perception of the Risk of Developing Prostate Cancer AN - 57303158; 200923754 AB - Although the higher risk of prostate cancer for African-American men is well known in the medical community, it is not clear how prevalent this knowledge is among African-American men themselves. Both the side effects of treatment and the lack of a demonstrated mortality benefit of routine screening with the prostate-specific antigen test among men in the general population have increased the focus on patient participation in decision making about prostate cancer screening. Methods Data on 1075 male respondents to the 2003 Health Information National Trends Study were collected from October 2002 to April 2003 and analyzed in 2008 to examine the associations among race/ethnicity, demographic characteristics, and the perception of the risk of developing prostate cancer for African-American, Hispanic, and non-Hispanic white men aged >=45 years without a history of prostate cancer. Results Nearly 50% of African-American men, 47.4% of Hispanic men, and 43.3% of non-Hispanic white men perceived their likelihood of getting prostate cancer as somewhat or very low. Nearly 18% of African-American men, 21.6% of Hispanic men, and 12.9% of non-Hispanic white men perceived themselves to be more likely to get prostate cancer than the average man of the same age. Conclusions Despite statistics to the contrary, few African-American men perceived themselves to have a higher-than-average risk of prostate cancer, while a higher percentage of Hispanic men perceived their risk to be higher than that of the average man of the same age. These findings suggest that all men, but particularly African-American and Hispanic men, could benefit from information regarding their specific risk of developing prostate cancer before making a decision about prostate cancer screening. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Shavers, Vickie L AU - Underwood, Willie AU - Moser, Richard P AD - Health Services and Economics Branch, Applied Research Program, National Cancer Institute, Bethesda, Maryland shaversv@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 64 EP - 67 PB - Elsevier Science, New York NY VL - 37 IS - 1 SN - 0749-3797, 0749-3797 KW - Screening KW - Black American people KW - Ethnicity KW - Men KW - Hispanic people KW - Prostatic cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57303158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Brief+report%3A+Race%2FEthnicity+and+the+Perception+of+the+Risk+of+Developing+Prostate+Cancer&rft.au=Shavers%2C+Vickie+L%3BUnderwood%2C+Willie%3BMoser%2C+Richard+P&rft.aulast=Shavers&rft.aufirst=Vickie&rft.date=2009-07-01&rft.volume=37&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2009.03.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Men; Prostatic cancer; Black American people; Hispanic people; Screening; Ethnicity DO - http://dx.doi.org/10.1016/j.amepre.2009.03.007 ER - TY - JOUR T1 - Stimulus-reinforcement-based decision making and anxiety: impairment in generalized anxiety disorder (GAD) but not in generalized social phobia (GSP) AN - 57301868; 200918428 AB - Generalized social phobia (GSP) involves the fear/avoidance of social situations whereas generalized anxiety disorder (GAD) involves an intrusive worry about everyday life circumstances. It remains unclear whether these, highly co-morbid, conditions represent distinct disorders or alternative presentations of a single underlying pathology. In this study, we examined stimulus-reinforcement-based decision making in GSP and GAD. Twenty unmedicated patients with GSP, 16 unmedicated patients with GAD and 19 age-, IQ- and gender-matched healthy comparison (HC) individuals completed the Differential Reward/Punishment Learning Task (DRPLT). In this task, the subject chooses between two objects associated with different levels of reward or punishment. Thus, response choice indexes not only reward/punishment sensitivity but also sensitivity to reward/punishment level according to between-object reinforcement distance. We found that patients with GAD committed a significantly greater number of errors than both the patients with GSP and the HC individuals. By contrast, the patients with GSP and the HC individuals did not differ in performance on this task. These results link GAD with anomalous non-affective-based decision making. They also indicate that GSP and GAD are associated with distinct pathophysiologies. Adapted from the source document. JF - Psychological Medicine AU - DeVido, J AU - Jones, M AU - Geraci, M AU - Hollon, N AU - Blair, R J R AU - Pine, D S AU - Blair, K AD - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1153 EP - 1161 PB - Cambridge University Press, UK VL - 39 IS - 7 SN - 0033-2917, 0033-2917 KW - Sensitivity KW - Decision making KW - Generalized anxiety disorders KW - Punishment KW - Social phobia KW - Rewards KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57301868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Stimulus-reinforcement-based+decision+making+and+anxiety%3A+impairment+in+generalized+anxiety+disorder+%28GAD%29+but+not+in+generalized+social+phobia+%28GSP%29&rft.au=DeVido%2C+J%3BJones%2C+M%3BGeraci%2C+M%3BHollon%2C+N%3BBlair%2C+R+J+R%3BPine%2C+D+S%3BBlair%2C+K&rft.aulast=DeVido&rft.aufirst=J&rft.date=2009-07-01&rft.volume=39&rft.issue=7&rft.spage=1153&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS003329170800487X LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Generalized anxiety disorders; Punishment; Rewards; Decision making; Social phobia; Sensitivity DO - http://dx.doi.org/10.1017/S003329170800487X ER - TY - JOUR T1 - Interindividual differences in neonatal imitation and the development of action chains in rhesus macaques AN - 37301800; 3948922 AB - The capacity to imitate facial gestures is highly variable in rhesus macaques and this variability may be related to differences in specific neurobehavioral patterns of development. This study evaluated the differential neonatal imitative response of 41 macaques in relation to the development of sensory, motor, and cognitive skills throughout the 1st month of life. The results show that infants who imitate facial gestures display more developed skills in goal-directed movements (reaching-grasping and fine hand motor control) than non-imitators. These differences might reflect, at least in part, the differential maturation of motor chains in the parietal and motor cortices, which partly overlap with those of the mirror neuron system. Thus, neonatal imitation appears to be a predictor of future neurobehavioral development. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Ferrari, Pier Francesco AU - Paukner, Annika AU - Ruggiero, Angela AU - Darcey, Lisa AU - Unbehagen, Sarah AU - Suomi, Stephen J AD - Università degli Studi di Parma ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1057 EP - 1068 VL - 80 IS - 4 SN - 0009-3920, 0009-3920 KW - Sociology KW - Facial expressions KW - Cognitive development KW - Neuroscience KW - Gestures KW - Child development KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37301800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Interindividual+differences+in+neonatal+imitation+and+the+development+of+action+chains+in+rhesus+macaques&rft.au=Ferrari%2C+Pier+Francesco%3BPaukner%2C+Annika%3BRuggiero%2C+Angela%3BDarcey%2C+Lisa%3BUnbehagen%2C+Sarah%3BSuomi%2C+Stephen+J&rft.aulast=Ferrari&rft.aufirst=Pier&rft.date=2009-07-01&rft.volume=80&rft.issue=4&rft.spage=1057&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2197 2212 6075 3483; 4720 8725 2572; 5499; 8637; 2450 6075 3483; 4783 ER - TY - JOUR T1 - Probing the neural correlates of anticipated peer evaluation in adolescence AN - 37300298; 3948919 AB - Neural correlates of social-cognition were assessed in 9- to- 17-year-olds (N = 34) using functional magnetic resonance imaging. Participants appraised how unfamiliar peers they had previously identified as being of high or low interest would evaluate them for an anticipated online chat session. Differential age- and sex-related activation patterns emerged in several regions previously implicated in affective processing. These included the ventral striatum, hippocampus, hypothalamus, and insula. In general, activation patterns shifted with age in older relative to younger females but showed no association with age in males. Relating these neural response patterns to changes in adolescent social-cognition enriches theories of adolescent social development through enhanced neurobiological understanding of social behavior. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Guyer, Amanda E AU - McClure-Tone, Erin B AU - Shiffrin, Nina D AU - Pine, Daniel S AU - Nelson, Eric E AD - National Institute of Mental Health ; Georgia State University Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1000 EP - 1015 VL - 80 IS - 4 SN - 0009-3920, 0009-3920 KW - Sociology KW - Magnetic Resonance Imaging KW - Social behaviour KW - Adolescence KW - Cognitive development KW - Social development KW - Child development KW - Social cognition KW - Family studies KW - Neurology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37300298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Probing+the+neural+correlates+of+anticipated+peer+evaluation+in+adolescence&rft.au=Guyer%2C+Amanda+E%3BMcClure-Tone%2C+Erin+B%3BShiffrin%2C+Nina+D%3BPine%2C+Daniel+S%3BNelson%2C+Eric+E&rft.aulast=Guyer&rft.aufirst=Amanda&rft.date=2009-07-01&rft.volume=80&rft.issue=4&rft.spage=1000&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2197 2212 6075 3483; 590 652 5676 646 6091; 8635; 11787 2449 10404; 11776; 11813 3483; 2450 6075 3483; 4783 ER - TY - JOUR T1 - Cancer prevention information-seeking among Hispanic and non-Hispanic users of the National Cancer Institute's Cancer Information Service: trends in telephone and livehelp use AN - 37137587; 3868916 AB - Evidence-based strategies to enable, encourage, and support cancer prevention information seeking among Hispanic populations are needed. We examined cancer prevention information requests to the Cancer Information Service (CIS) via telephone (1-800-4-CANCER toll-free telephone information service) and LiveHelp (an instant messaging service provided in English only) from 2003 to 2006. We summarized differences in the communication channel utilized by ethnicity (Hispanic vs. non-Hispanic) and, among Hispanic information seekers, the language used during the contact (English vs. Spanish). Utilization of LiveHelp was higher among non-Hispanic than Hispanic seekers of cancer prevention information. LiveHelp use for seeking cancer prevention information increased between 2003 and 2006 for both groups, but the increase was greater among non-Hispanics than Hispanics. Nearly half of Hispanics who sought cancer prevention information did so in Spanish. Because LiveHelp is not available in Spanish, the number of Spanish-only speakers who preferred to contact CIS via LiveHelp instead of telephone is unknown. When communicating cancer prevention information via multiple channels, it is important to consider differences in access to communication technologies and preferred communication channels among ethnic minority groups. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Waters, Erika AU - Sullivan, Helen AU - Finney Rutten, Lila AD - National Cancer Institute, US Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 476 EP - 486 VL - 14 IS - 5 SN - 1081-0730, 1081-0730 KW - Sociology KW - Screening KW - Communication KW - Hispanic-Americans KW - Health KW - U.S.A. KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37137587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Cancer+prevention+information-seeking+among+Hispanic+and+non-Hispanic+users+of+the+National+Cancer+Institute%27s+Cancer+Information+Service%3A+trends+in+telephone+and+livehelp+use&rft.au=Waters%2C+Erika%3BSullivan%2C+Helen%3BFinney+Rutten%2C+Lila&rft.aulast=Waters&rft.aufirst=Erika&rft.date=2009-07-01&rft.volume=14&rft.issue=5&rft.spage=476&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730903032952 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5864 4424 5865 961; 1939 3617 6220; 5772; 2572; 433 293 14 DO - http://dx.doi.org/10.1080/10810730903032952 ER - TY - JOUR T1 - OspC-Independent Infection and Dissemination by Host-Adapted Borrelia burgdorferi AN - 21504913; 12511299 AB - Borrelia burgdorferi OspC is required for the spirochete to establish infection in a mammal by tick transmission or needle inoculation. After a brief essential period, the protein no longer is required and the gene can be shut off. Using a system in which spirochetes contain only an unstable wild-type copy of the ospC gene, we can obtain mice persistently infected with bacteria lacking OspC. We implanted pieces of infected mouse skin subcutaneously in naive mice, using donors carrying wild-type or ospC mutant spirochetes, and found that both could infect mice by this method, with similar numbers of wild-type or ospC mutant spirochetes disseminated throughout the tissues of recipient mice. Recipient mouse immune responses to tissue transfer-mediated infection with wild-type or ospC mutant spirochetes were similar. These experiments demonstrate that mammalian host-adapted spirochetes can infect and disseminate in mice in the absence of OspC, thereby circumventing this hallmark of tick-derived or in vitro-grown spirochetes. We propose a model in which OspC is one of a succession of functionally equivalent, essential proteins that are synthesized at different stages of mammalian infection. In this model, another protein uniquely present on host-adapted spirochetes performs the same essential function initially fulfilled by OspC. The strict temporal control of B. burgdorferi outer surface protein gene expression may reflect immunological constraints rather than distinct functions. JF - Infection and Immunity AU - Tilly, Kit AU - Bestor, Aaron AU - Dulebohn, Daniel P AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, ktilly@niaid.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 2672 EP - 2682 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 7 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Animal models KW - Gene expression KW - Immune response KW - Infection KW - Inoculation KW - Models KW - Skin KW - Spirochetes KW - Succession KW - ospC gene KW - outer surface proteins KW - Borrelia burgdorferi KW - Ixodidae KW - J 02350:Immunology KW - A 01390:Forestry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21504913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.atitle=Highly+Polarized+Th1+Cells+as+Regulatory+T+Cells&rft.au=Jankovic%2C+Dragana&rft.aulast=Jankovic&rft.aufirst=Dragana&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Gene expression; Spirochetes; Skin; outer surface proteins; Inoculation; Animal models; ospC gene; Immune response; Succession; Infection; Models; Borrelia burgdorferi; Ixodidae DO - http://dx.doi.org/10.1128/IAI.01193-08 ER - TY - JOUR T1 - Anti-Apical-Membrane-Antigen-1 Antibody Is More Effective than Anti-42-Kilodalton-Merozoite-Surface-Protein-1 Antibody in Inhibiting Plasmodium falciparum Growth, as Determined by the In Vitro Growth Inhibition Assay AN - 21482543; 12492645 AB - Apical membrane antigen 1 (AMA1) and the 42-kDa merozoite surface protein 1 (MSP142) are leading malaria vaccine candidates. Several preclinical and clinical trials have been conducted, and an in vitro parasite growth inhibition assay has been used to evaluate the biological activities of the resulting antibodies. In a U.S. phase 1 trial with AMA1-C1/Alhydrogel plus CPG 7909, the vaccination elicited anti-AMA1 immunoglobulin G (IgG) which showed up to 96% inhibition. However, antibodies induced by MSP142-C1/Alhydrogel plus CPG 7909 vaccine showed less than 32% inhibition in vitro. To determine whether anti-MSP142 IgG had less growth-inhibitory activity than anti-AMA1 IgG in vitro, the amounts of IgG that produced 50% inhibition of parasite growth (Ab50) were compared for rabbit and human antibodies. The Ab50s of rabbit and human anti-MSP142 IgGs were significantly higher (0.21 and 0.62 mg/ml, respectively) than those of anti-AMA1 IgGs (0.07 and 0.10 mg/ml, respectively) against 3D7 parasites. Ab50 data against FVO parasites also demonstrated significant differences. We further investigated the Ab50s of mouse and monkey anti-AMA1 IgGs and showed that there were significant differences between the species (mouse, 0.28 mg/ml, and monkey, 0.14 mg/ml, against 3D7 parasites). Although it is unknown whether growth-inhibitory activity in vitro reflects protective immunity in vivo, this study showed that the Ab50 varies with both antigen and species. Our data provide a benchmark for antibody levels for future AMA1- or MSP142-based vaccine development efforts in preclinical and clinical trials. JF - Clinical and Vaccine Immunology AU - Miura, Kazutoyo AU - Zhou, Hong AU - Diouf, Ababacar AU - Moretz, Samuel E AU - Fay, Michael P AU - Miller, Louis H AU - Martin, Laura B AU - Pierce, Mark A AU - Ellis, Ruth D AU - D Mullen, Gregory E AU - Long, Carole A AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Twinbrook 3, Rockville, Maryland 20852, kmiura@niaid.nih.gov kmiura@niaid.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 963 EP - 968 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 16 IS - 7 SN - 1556-679X, 1556-679X KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Apical membrane antigen 1 KW - Parasites KW - Data processing KW - Disease control KW - Man-induced effects KW - Merozoite surface protein 1 KW - Malaria KW - Plasmodium falciparum KW - CpG islands KW - Immunity KW - Clinical trials KW - Vaccination KW - Public health KW - USA KW - Antibodies KW - Growth KW - Antigens KW - Immunoglobulin G KW - Vaccines KW - K 03350:Immunology KW - F 06905:Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21482543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Anti-Apical-Membrane-Antigen-1+Antibody+Is+More+Effective+than+Anti-42-Kilodalton-Merozoite-Surface-Protein-1+Antibody+in+Inhibiting+Plasmodium+falciparum+Growth%2C+as+Determined+by+the+In+Vitro+Growth+Inhibition+Assay&rft.au=Miura%2C+Kazutoyo%3BZhou%2C+Hong%3BDiouf%2C+Ababacar%3BMoretz%2C+Samuel+E%3BFay%2C+Michael+P%3BMiller%2C+Louis+H%3BMartin%2C+Laura+B%3BPierce%2C+Mark+A%3BEllis%2C+Ruth+D%3BD+Mullen%2C+Gregory+E%3BLong%2C+Carole+A&rft.aulast=Miura&rft.aufirst=Kazutoyo&rft.date=2009-07-01&rft.volume=16&rft.issue=7&rft.spage=963&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00042-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Growth; Antibodies; Antigens; Disease control; Man-induced effects; Immunity; Vaccines; Public health; Apical membrane antigen 1; Data processing; Immunoglobulin G; Malaria; Merozoite surface protein 1; CpG islands; Vaccination; Clinical trials; Plasmodium falciparum; USA DO - http://dx.doi.org/10.1128/CVI.00042-09 ER - TY - JOUR T1 - Developmental Perspectives on Nutrition and Obesity From Gestation to Adolescence AN - 21447426; 11861265 AB - Obesity results from a complex combination of factors that act at many stages throughout a person's life. Therefore, examining childhood nutrition and obesity from a developmental perspective is warranted. A developmental perspective recognizes the cumulative effects of factors that contribute to eating behavior and obesity, including biological and socioenvironmental factors that are relevant at different stages of development. A developmental perspective considers family, school, and community context. During gestation, risk factors for obesity include maternal diet, overweight, and smoking. In early childhood, feeding practices, taste acquisition, and eating in the absence of hunger must be considered. As children become more independent during middle childhood and adolescence, school nutrition, food marketing, and social networks become focal points for obesity prevention or intervention. Combining a multilevel approach with a developmental perspective can inform more effective and sustainable strategies for obesity prevention. JF - Preventing Chronic Disease AU - Huang, Terry T AU - Esposito, Layla AU - Fisher, Jennifer O AU - Mennella, Julie A AU - Hoelscher, Deanna M Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1 PB - U.S. Dept. of Health and Human Services, Centers for Disease Control and Prevention, Epidemiology Program Office Atlanta GA 30333 USA VL - 6 IS - 3 KW - Physical Education Index KW - Obesity KW - Schools KW - Eating disorders KW - Preventive health KW - Adolescence KW - Diet KW - Children KW - Nutrition KW - Perspective KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21447426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventing+Chronic+Disease&rft.atitle=Developmental+Perspectives+on+Nutrition+and+Obesity+From+Gestation+to+Adolescence&rft.au=Huang%2C+Terry+T%3BEsposito%2C+Layla%3BFisher%2C+Jennifer+O%3BMennella%2C+Julie+A%3BHoelscher%2C+Deanna+M&rft.aulast=Huang&rft.aufirst=Terry&rft.date=2009-07-01&rft.volume=6&rft.issue=3&rft.spage=A94&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.issn=&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obesity; Perspective; Nutrition; Preventive health; Adolescence; Eating disorders; Diet; Schools; Children ER - TY - JOUR T1 - Adolescent Obesity and Social Networks AN - 21444707; 11861261 AB - The prevalence of overweight among children worldwide is growing at an alarming rate. Social relationships may contribute to the development of obesity through the interaction of biological, behavioral, and environmental factors. Although there is evidence that early environment influences the expression of obesity, very little research elucidates the social context of obesity among children or adolescents. Social network approaches can contribute to research on the role of social environments in overweight and obesity and strengthen interventions to prevent disease and promote health. By capitalizing on the structure of the network system, a targeted intervention that uses social relationships in families, schools, neighborhoods, and communities may be successful in encouraging healthful behaviors among children and their families. JF - Preventing Chronic Disease AU - Koehly, Laura M AU - Loscalzo, Aunchalee Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1 PB - U.S. Dept. of Health and Human Services, Centers for Disease Control and Prevention, Epidemiology Program Office Atlanta GA 30333 USA VL - 6 IS - 3 KW - Physical Education Index KW - Obesity KW - Schools KW - Preventive health KW - Promotion KW - Adolescence KW - Family KW - Health KW - Chronic diseases KW - Children KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21444707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventing+Chronic+Disease&rft.atitle=Adolescent+Obesity+and+Social+Networks&rft.au=Koehly%2C+Laura+M%3BLoscalzo%2C+Aunchalee&rft.aulast=Koehly&rft.aufirst=Laura&rft.date=2009-07-01&rft.volume=6&rft.issue=3&rft.spage=A99&rft.isbn=&rft.btitle=&rft.title=Preventing+Chronic+Disease&rft.issn=1545-1151&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obesity; Children; Adolescence; Family; Preventive health; Promotion; Chronic diseases; Health; Schools ER - TY - JOUR T1 - Invasive Aspergillosis Due to Neosartorya udagawae AN - 21430241; 12488913 AB - Background. Invasive aspergillosis (IA) is most commonly caused by the morphospecies Aspergillus fumigatus. However, genetic-based methods indicate that organisms phenotypically identified as A. fumigatus actually constitute a mold complex, designated Aspergillus section fumigati subgenus fumigati. Methods. Multilocus sequencing and analysis was performed on fungi identified as A. fumigatus from the clinical culture collection maintained at the National Institutes of Health from 2000 through 2008, with a focus on the internal transcribed spacer 1 and 2 regions of ribosomal DNA (rDNA), b-tubulin, and rodlet A genes. We reviewed the medical records, radiology, and histopathology of corresponding patients. To confirm identification of Neosartorya udagawae isolates, mating studies were performed with reference strains. Antifungal susceptibility testing was performed by broth microdilution and read at 48 hours. Results. Thirty-six cases of infection attributed to A. fumigatus were identified; 4 were caused by N. udagawae (3 In patients with chronic granulomatous disease and 1 in a patient with myelodysplastic syndrome). Disease due to N. udagawae was chronic, with a median duration of 35 weeks, compared with a median duration of 5.5 weeks for patients with chronic granulomatous disease who had infection due to A. fumigatus sensu stricto (P < .05, Mann-Whitney U test). Infection spread across anatomical planes in a contiguous manner and was refractory to standard therapy. Two of the 4 patients died. N. udagawae demonstrated relatively higher minimum inhibitory concentrations to various agents, compared with those demonstrated by contemporary A. fumigatus sensu stricto isolates. Conclusions. To our knowledge, this is the first report documenting infection due to N. udagawae. Clinical manifestations were distinct from those of typical IA. Fumigati-mimetics with inherent potential for antifungal resistance are agents of IA. Genetic identification of molds should be considered for unusual or refractory IA. JF - Clinical Infectious Diseases AU - Vinh, D C AU - Shea, Y R AU - Sugui, JA AU - Parrilla-Castellar, ER AU - Freeman, A F AU - Campbell, J W AU - Pittaluga, S AU - Jones, P A AU - Zelazny, A AU - Kleiner, D AU - Kwon-Chung, K J AU - Holland, S M AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10CRC, Rm. B3-4141 MSC 1684, Bethesda, MD 20892-1684, USA, smh@nih.gov Y1 - 2009/07/01/ PY - 2009 DA - 2009 Jul 01 SP - 102 EP - 111 VL - 49 IS - 1 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - medical records KW - Fungi KW - Molds KW - Aspergillosis KW - Spacer KW - Radiology KW - Minimum inhibitory concentration KW - Myelodysplastic syndrome KW - Mating KW - DNA sequencing KW - Aspergillus fumigatus KW - Chronic infection KW - DNA KW - Neosartorya KW - Culture collections KW - Tubulin KW - Chronic granulomatous disease KW - A 01360:Plant Diseases KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21430241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Invasive+Aspergillosis+Due+to+Neosartorya+udagawae&rft.au=Vinh%2C+D+C%3BShea%2C+Y+R%3BSugui%2C+JA%3BParrilla-Castellar%2C+ER%3BFreeman%2C+A+F%3BCampbell%2C+J+W%3BPittaluga%2C+S%3BJones%2C+P+A%3BZelazny%2C+A%3BKleiner%2C+D%3BKwon-Chung%2C+K+J%3BHolland%2C+S+M&rft.aulast=Vinh&rft.aufirst=D&rft.date=2009-07-01&rft.volume=49&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F599345 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - medical records; Fungi; Molds; Spacer; Aspergillosis; Radiology; Minimum inhibitory concentration; Mating; Myelodysplastic syndrome; DNA sequencing; Chronic infection; DNA; Culture collections; Chronic granulomatous disease; Tubulin; Aspergillus fumigatus; Neosartorya DO - http://dx.doi.org/10.1086/599345 ER - TY - JOUR T1 - The Coxiella burnetii Ankyrin Repeat Domain-Containing Protein Family Is Heterogeneous, with C-Terminal Truncations That Influence Dot/Icm-Mediated Secretion AN - 21327711; 11916827 AB - Coxiella burnetii is an obligate intracellular bacterium that directs biogenesis of a parasitophorous vacuole (PV) for replication. Effectors of PV maturation are likely translocated into the host cytosol by a type IV secretion system (T4SS) with homology to the Dot/Icm apparatus of Legionella pneumophila. Since secreted bacterial virulence factors often functionally mimic the activities of host proteins, prokaryotic proteins with eukaryotic features are considered candidate T4SS substrates. Genes encoding proteins with eukaryotic-type ankyrin repeat domains (Anks) were identified upon genome sequencing of the C. burnetii Nine Mile reference isolate, which is associated with a case of human acute Q fever. Interestingly, recent genome sequencing of the G and K isolates, derived from human chronic endocarditis patients, and of the Dugway rodent isolate revealed remarkable heterogeneity in the Ank gene family, with the Dugway isolate harboring the largest number of full-length Ank genes. Using L. pneumophila as a surrogate host, we identified 10 Dugway Anks and 1 Ank specific to the G and K endocarditis isolates translocated into the host cytosol in a Dot/Icm-dependent fashion. A 10-amino-acid C-terminal region appeared to be necessary for translocation, with some Anks also requiring the chaperone IcmS for secretion. Ectopically expressed Anks localized to a variety of subcellular regions in mammalian cells, including microtubules, mitochondria, and the PV membrane. Collectively, these data suggest that C. burnetii isolates translocate distinct subsets of the Ank protein family into the host cytosol, where they modulate diverse functions, some of which may be unique to C. burnetii pathotypes. JF - Journal of Bacteriology AU - Voth, Daniel E AU - Howe, Dale AU - Beare, Paul A AU - Vogel, Joseph P AU - Unsworth, Nathan AU - Samuel, James E AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, rheinzen@niaid.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 4232 EP - 4242 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 13 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Genomes KW - ANK protein KW - Legionella pneumophila KW - Microtubules KW - Data processing KW - virulence factors KW - Replication KW - Secretion KW - Mitochondria KW - protein families KW - Endocarditis KW - parasitophorous vacuole KW - Coxiella burnetii KW - Homology KW - Mammalian cells KW - Ankyrin KW - Cytosol KW - Chaperones KW - Q fever KW - Translocation KW - J 02330:Biochemistry KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21327711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Coxiella+burnetii+Ankyrin+Repeat+Domain-Containing+Protein+Family+Is+Heterogeneous%2C+with+C-Terminal+Truncations+That+Influence+Dot%2FIcm-Mediated+Secretion&rft.au=Voth%2C+Daniel+E%3BHowe%2C+Dale%3BBeare%2C+Paul+A%3BVogel%2C+Joseph+P%3BUnsworth%2C+Nathan%3BSamuel%2C+James+E%3BHeinzen%2C+Robert+A&rft.aulast=Voth&rft.aufirst=Daniel&rft.date=2009-07-01&rft.volume=191&rft.issue=13&rft.spage=4232&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01656-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 58 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - ANK protein; Genomes; Microtubules; Data processing; virulence factors; Replication; Secretion; protein families; Mitochondria; Endocarditis; parasitophorous vacuole; Mammalian cells; Homology; Cytosol; Ankyrin; Chaperones; Translocation; Q fever; Legionella pneumophila; Coxiella burnetii DO - http://dx.doi.org/10.1128/JB.01656-08 ER - TY - JOUR T1 - Cohort Study of Molecular Identification and Typing of Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium bolletii AN - 21310630; 12511898 AB - Mycobacterium abscessus is the most common cause of rapidly growing mycobacterial chronic lung disease. Recently, two new M. abscessus-related species, M. massiliense and M. bolletii, have been described. Health care-associated outbreaks have recently been investigated by the use of molecular identification and typing tools; however, very little is known about the natural epidemiology and pathogenicity of M. massiliense or M. bolletii outside of outbreak situations. The differentiation of these two species from M. abscessus is difficult and relies on the sequencing of one or more housekeeping genes. We performed extensive molecular identification and typing of 42 clinical isolates of M. abscessus, M. massiliense, and M. bolletii from patients monitored at the NIH between 1999 and 2007. The corresponding clinical data were also examined. Partial sequencing of rpoB, hsp65, and secA led to the unambiguous identification of 26 M. abscessus isolates, 7 M. massiliense isolates, and 2 M. bolletii isolates. The identification results for seven other isolates were ambiguous and warranted further sequencing and an integrated phylogenetic analysis. Strain relatedness was assessed by repetitive-sequence-based PCR (rep-PCR) and pulsed-field gel electrophoresis (PFGE), which showed the characteristic clonal groups for each species. Five isolates with ambiguous species identities as M. abscessus-M. massiliense by rpoB, hsp65, and secA sequencing clustered as a distinct group by rep-PCR and PFGE together with the M. massiliense type strain. Overall, the clinical manifestations of disease caused by each species were similar. In summary, a multilocus sequencing approach (not just rpoB partial sequencing) is required for division of M. abscessus and closely related species. Molecular typing complements sequence-based identification and provides information on prevalent clones with possible relevant clinical aspects. JF - Journal of Clinical Microbiology AU - Zelazny, Adrian M AU - Root, Jeremy M AU - Shea, Yvonne R AU - Colombo, Rhonda E AU - Shamputa, Isdore C AU - Stock, Frida AU - Conlan, Sean AU - McNulty, Steven AU - Brown-Elliott, Barbara A AU - Wallace Jr, Richard J AU - Olivier, Kenneth N AU - Holland, Steven M AU - Sampaio, Elizabeth P AD - Immunopathogenesis Section, azelazny@mail.nih.gov azelazny@mail.nih.gov azelazny@mail.nih.gov azelazny@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1985 EP - 1995 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 47 IS - 7 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Clinical isolates KW - Heat shock proteins KW - Data processing KW - Mycobacterium KW - Lung diseases KW - Clinical aspects KW - Hsp65 protein KW - Differentiation KW - Typing KW - Mycobacterium abscessus KW - Pathogenicity KW - Epidemiology KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - RpoB protein KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21310630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.atitle=Role+of+Novel+H2S+releasing+NSAIDs+in+Non-Small+Lung+Cancer&rft.au=Moody%2C+Terry&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Phylogeny; Heat shock proteins; Data processing; Lung diseases; Hsp65 protein; Clinical aspects; Differentiation; Typing; Epidemiology; Pathogenicity; Pulsed-field gel electrophoresis; Polymerase chain reaction; RpoB protein; Mycobacterium abscessus; Mycobacterium DO - http://dx.doi.org/10.1128/JCM.01688-08 ER - TY - JOUR T1 - Active Transcription of rRNA Operons Condenses the Nucleoid in Escherichia coli: Examining the Effect of Transcription on Nucleoid Structure in the Absence of Transertion AN - 21308731; 11916829 AB - In Escherichia coli the genome must be compacted 1,000-fold to be contained in a cellular structure termed the nucleoid. It is proposed that the structure of the nucleoid is determined by a balance of multiple compaction forces and one major expansion force. The latter is mediated by transertion, a coupling of transcription, translation, and translocation of nascent membrane proteins and/or exported proteins. In supporting this notion, it has been shown consistently that inhibition of transertion by the translation inhibitor chloramphenicol results in nucleoid condensation due to the compaction forces that remain active in the cell. Our previous study showed that during optimal growth, RNA polymerase is concentrated into transcription foci or "factories," analogous to the eukaryotic nucleolus, indicating that transcription and RNA polymerase distribution affect the nucleoid structure. However, the interpretation of the role of transcription in the structure of the nucleoid is complicated by the fact that transcription is implicated in both compacting forces and the expansion force. In this work, we used a new approach to further examine the effect of transcription, specifically from rRNA operons, on the structure of the nucleoid, when the major expansion force was eliminated. Our results showed that transcription is necessary for the chloramphenicol-induced nucleoid compaction. Further, an active transcription from multiple rRNA operons in chromosome is critical for the compaction of nucleoid induced by inhibition of translation. All together, our data demonstrated that transcription of rRNA operons is a key mechanism affecting genome compaction and nucleoid structure. JF - Journal of Bacteriology AU - Cabrera, Julio E AU - Cagliero, Cedric AU - Quan, Selwyn AU - Squires, Catherine L AU - Jin, Ding Jun AD - Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland 21702, djjin@helix.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 4180 EP - 4185 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 13 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Translation KW - Nucleoli KW - Chloramphenicol KW - Data processing KW - Transcription KW - Membrane proteins KW - Compaction KW - rRNA KW - Chromosomes KW - DNA-directed RNA polymerase KW - Chromosome translocations KW - Escherichia coli KW - Condensation KW - Nucleoids KW - Operons KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21308731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Active+Transcription+of+rRNA+Operons+Condenses+the+Nucleoid+in+Escherichia+coli%3A+Examining+the+Effect+of+Transcription+on+Nucleoid+Structure+in+the+Absence+of+Transertion&rft.au=Cabrera%2C+Julio+E%3BCagliero%2C+Cedric%3BQuan%2C+Selwyn%3BSquires%2C+Catherine+L%3BJin%2C+Ding+Jun&rft.aulast=Cabrera&rft.aufirst=Julio&rft.date=2009-07-01&rft.volume=191&rft.issue=13&rft.spage=4180&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01707-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 53 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Genomes; Translation; Chloramphenicol; Nucleoli; Data processing; Transcription; Membrane proteins; Compaction; rRNA; DNA-directed RNA polymerase; Chromosomes; Chromosome translocations; Nucleoids; Condensation; Operons; Escherichia coli DO - http://dx.doi.org/10.1128/JB.01707-08 ER - TY - JOUR T1 - Heteroresistance to Fluconazole in Cryptococcus neoformans Is Intrinsic and Associated with Virulence , AN - 21253097; 11811489 AB - In 1999, heteroresistance to triazoles was reported in Cryptococcus neoformans strains isolated from an azole therapy failure case of cryptococcosis in an AIDS patient and in a diagnostic strain from a non-AIDS patient. In this study, we analyzed 130 strains of C. neoformans isolated from clinical and environmental sources before 1979, prior to the advent of triazoles, and 16 fluconazole (FLC)-resistant strains isolated from AIDS patients undergoing FLC maintenance therapy during 1990 to 2000. All strains isolated prior to 1979 manifested heteroresistance (subset of a population that grows in the presence of FLC) at concentrations between 4 and 64 kg/ml, and all 16 FLC-resistant AIDS isolates manifested heteroresistance at concentrations between 16 and 128 kg/ml. Upon exposure to stepwise increases in the concentration of FLC, subpopulations that could grow at higher concentrations emerged. Repeated transfer on drug-free media caused the highly resistant subpopulations to revert to the original level of heteroresistance. The reversion pattern fell into four categories based on the number of transfers required. The strains heteroresistant at 32 kg/ml were significantly more resistant to other xenobiotics and were also more virulent in mice than were those heteroresistant at 8 kg/ml. During FLC treatment of mice infected by strains with low levels of heteroresistance, subpopulations exhibiting higher levels of heteroresistance emerged after a certain period of time. The ABC transporter AFR1, known to efflux FLC, was unrelated to the heteroresistance mechanism. Our study showed that heteroresistance to azole is universal and suggests that heteroresistance contributes to relapse of cryptococcosis during azole maintenance therapy. JF - Antimicrobial Agents & Chemotherapy AU - Sionov, Edward AU - Chang, Yun C AU - Garraffo, HMartin AU - Kwon-Chung, Kyung J AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, June_Kwon-Chung@nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 2804 EP - 2815 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 53 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Virulence KW - Acquired immune deficiency syndrome KW - fluconazole KW - Cryptococcus neoformans KW - triazoles KW - ABC transporter KW - Subpopulations KW - Reversion KW - Xenobiotics KW - Cryptococcosis KW - azoles KW - K 03410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21253097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Heteroresistance+to+Fluconazole+in+Cryptococcus+neoformans+Is+Intrinsic+and+Associated+with+Virulence+%2C&rft.au=Sionov%2C+Edward%3BChang%2C+Yun+C%3BGarraffo%2C+HMartin%3BKwon-Chung%2C+Kyung+J&rft.aulast=Sionov&rft.aufirst=Edward&rft.date=2009-07-01&rft.volume=53&rft.issue=7&rft.spage=2804&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00295-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Virulence; Acquired immune deficiency syndrome; fluconazole; ABC transporter; triazoles; Subpopulations; Reversion; Xenobiotics; Cryptococcosis; azoles; Cryptococcus neoformans DO - http://dx.doi.org/10.1128/AAC.00295-09 ER - TY - JOUR T1 - Radiation Metabolomics. 2. Dose- and Time-Dependent Urinary Excretion of Deaminated Purines and Pyrimidines after Sublethal Gamma-Radiation Exposure in Mice AN - 21146629; 11204350 AB - Tyburski, J. B., Patterson, A. D., Krausz, K. W., Slavik, J., Fornace, A. J. Jr., Gonzalez, F. J. and Idle, J. R. Radiation Metabolomics. 2. Dose- and Time-Dependent Urinary Excretion of Deaminated Purines and Pyrimidines after Sublethal Gamma-Radiation Exposure in Mice. Radiat. Res. 172, 42-57 (2009). JF - Radiation Research AU - Tyburski, John B AU - Patterson, Andrew D AU - Krausz, Kristopher W AU - Slavik, Josef AU - Fornace, Albert J AU - Gonzalez, Frank J AU - Idle, Jeffrey R AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 42 EP - 57 PB - Radiation Research Society VL - 172 IS - 1 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - pyrimidines KW - Excretion KW - metabolomics KW - purines KW - X 24390:Radioactive Materials KW - N 14840:Antisense, Nucleotide Analogs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21146629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Radiation+Metabolomics.+2.+Dose-+and+Time-Dependent+Urinary+Excretion+of+Deaminated+Purines+and+Pyrimidines+after+Sublethal+Gamma-Radiation+Exposure+in+Mice&rft.au=Tyburski%2C+John+B%3BPatterson%2C+Andrew+D%3BKrausz%2C+Kristopher+W%3BSlavik%2C+Josef%3BFornace%2C+Albert+J%3BGonzalez%2C+Frank+J%3BIdle%2C+Jeffrey+R&rft.aulast=Tyburski&rft.aufirst=John&rft.date=2009-07-01&rft.volume=172&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1703.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - pyrimidines; Excretion; purines; metabolomics DO - http://dx.doi.org/10.1667/RR1703.1 ER - TY - JOUR T1 - Biofilms of streptococci and veillonellae: Interactions in vitro and in the Oral Cavity. AN - 21128399; 10297316 JF - Microscopy and Microanalysis AU - Jr., RJ Palmer AU - Egland, P G AU - Kolenbrander, P E AD - National Institutes of Health Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 820 EP - 821 PB - Cambridge University Press, 32 Avenue of the Americas New York NY 10013-2473 USA VL - 15 IS - S2 SN - 1431-9276, 1431-9276 KW - Microbiology Abstracts B: Bacteriology KW - Biofilms KW - Oral cavity KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21128399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microscopy+and+Microanalysis&rft.atitle=Biofilms+of+streptococci+and+veillonellae%3A+Interactions+in+vitro+and+in+the+Oral+Cavity.&rft.au=Jr.%2C+RJ+Palmer%3BEgland%2C+P+G%3BKolenbrander%2C+P+E&rft.aulast=Jr.&rft.aufirst=RJ&rft.date=2009-07-01&rft.volume=15&rft.issue=S2&rft.spage=820&rft.isbn=&rft.btitle=&rft.title=Microscopy+and+Microanalysis&rft.issn=14319276&rft_id=info:doi/10.1017%2FS1431927609092198 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Biofilms; Oral cavity DO - http://dx.doi.org/10.1017/S1431927609092198 ER - TY - JOUR T1 - Exposure and Effect Assessment of Aerosolized Red Tide Toxins (Brevetoxins) and Asthma AN - 21074695; 10989530 AB - Background In previous studies we demonstrated statistically significant changes in reported symptoms for lifeguards, general beach goers, and persons with asthma, as well as statistically significant changes in pulmonary function tests (PFTs) in asthmatics, after exposure to brevetoxins in Florida red tide (Karenia brevis bloom) aerosols. Objectives In this study we explored the use of different methods of intensive ambient and personal air monitoring to characterize these exposures to predict self-reported health effects in our asthmatic study population. Methods We evaluated health effects in 87 subjects with asthma before and after 1 hr of exposure to Florida red tide aerosols and assessed for aerosolized brevetoxin exposure using personal and ambient samplers. Results After only 1 hr of exposure to Florida red tide aerosols containing brevetoxin concentrations > 57 ng/m super(3), asthmatics had statistically significant increases in self-reported respiratory symptoms and total symptom scores. However, we did not see the expected corresponding changes in PFT results. Significant increases in self-reported symptoms were also observed for those not using asthma medication and those living aY 1 mile from the coast. Conclusions These results provide additional evidence of health effects in asthmatics from ambient exposure to aerosols containing very low concentrations of brevetoxins, possibly at the lower threshold for inducing a biologic response (i.e., toxicity). Consistent with the literature describing self-reported symptoms as an accurate measure of asthmatic distress, our results suggest that self-reported symptoms are a valuable measure of the extent of health effects from exposure to aerosolized brevetoxins in asthmatic populations. JF - Environmental Health Perspectives AU - Fleming, Lora E AU - Bean, Judy A AU - Kirkpatrick, Barbara AU - Cheng, Yung Sung AU - Pierce, Richard AU - Naar, Jerome AU - Nierenberg, Kate AU - Backer, Lorraine C AU - Wanner, Adam AU - Reich, Andrew AU - Zhou, Yue AU - Watkins, Sharon AU - Henry, Mike AU - Zaias, Julia AU - Abraham, William M AU - Benson, Janet AU - Cassedy, Amy AU - Hollenbeck, Julie AU - Kirkpatrick, Gary AU - Clarke, Tainya AU - Baden, Daniel G AD - National Science Foundation National Institute of Environmental Health Sciences Oceans and Human Health Center, University of Miami Rosenstiel School of Marine and Atmospheric Sciences, Miami, Florida, USA Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1095 EP - 1100 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 117 IS - 7 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts; Pollution Abstracts; Environment Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts KW - asthma KW - brevetoxins KW - harmful algal blooms (HABs) KW - Karenia brevis KW - red tides KW - sensitive populations KW - spirometry KW - Noxious organisms KW - Algal blooms KW - USA, Florida KW - Phytoplankton KW - Respiratory diseases KW - Public health KW - Exposure KW - Environmental monitoring KW - ASW, USA, Florida KW - Aerosols KW - Asthma KW - Toxins KW - Coastal zone KW - Brevetoxins KW - Monitoring KW - Pollution monitoring KW - Symptoms KW - Red tides KW - Statistical analysis KW - Assessments KW - Respiratory function KW - Drugs KW - Coasts KW - Marine KW - Beaches KW - Population studies KW - Toxicity KW - Samplers KW - Lung KW - Red Tide KW - X 24370:Natural Toxins KW - SW 3030:Effects of pollution KW - AQ 00008:Effects of Pollution KW - Q1 08481:Productivity KW - Q5 08524:Public health, medicines, dangerous organisms KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21074695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+and+Effect+Assessment+of+Aerosolized+Red+Tide+Toxins+%28Brevetoxins%29+and+Asthma&rft.au=Fleming%2C+Lora+E%3BBean%2C+Judy+A%3BKirkpatrick%2C+Barbara%3BCheng%2C+Yung+Sung%3BPierce%2C+Richard%3BNaar%2C+Jerome%3BNierenberg%2C+Kate%3BBacker%2C+Lorraine+C%3BWanner%2C+Adam%3BReich%2C+Andrew%3BZhou%2C+Yue%3BWatkins%2C+Sharon%3BHenry%2C+Mike%3BZaias%2C+Julia%3BAbraham%2C+William+M%3BBenson%2C+Janet%3BCassedy%2C+Amy%3BHollenbeck%2C+Julie%3BKirkpatrick%2C+Gary%3BClarke%2C+Tainya%3BBaden%2C+Daniel+G&rft.aulast=Fleming&rft.aufirst=Lora&rft.date=2009-07-01&rft.volume=117&rft.issue=7&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0900673 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Environmental monitoring; Noxious organisms; Algal blooms; Symptoms; Coastal zone; Aerosols; Red tides; Phytoplankton; Public health; Beaches; Lung; Brevetoxins; Statistical analysis; Population studies; Asthma; Toxicity; Samplers; Toxins; Coasts; Pollution monitoring; Respiratory function; Respiratory diseases; Drugs; Assessments; Exposure; Red Tide; Monitoring; Karenia brevis; ASW, USA, Florida; USA, Florida; Marine DO - http://dx.doi.org/10.1289/ehp.0900673 ER - TY - JOUR T1 - Occupational exposure to diesel engine exhaust: A literature review AN - 20941095; 10986281 AB - Diesel exhaust (DE) is classified as a probable human carcinogen. Aims were to describe the major occupational uses of diesel engines and give an overview of personal DE exposure levels and determinants of exposure as reported in the published literature. Measurements representative of personal DE exposure were abstracted from the literature for the following agents: elemental carbon (EC), particulate matter (PM), carbon monoxide (CO), nitrogen oxide (NO), and nitrogen dioxide (NO sub(2)). Information on determinants of exposure was abstracted. In total, 3528 EC, 4166 PM, 581 CO, 322 NO, and 1404 NO sub(2) measurements were abstracted. From the 10,001 measurements, 32% represented exposure from on-road vehicles and 68% from off-road vehicles (30% mining, 15% railroad, and 22% others). Highest levels were reported for enclosed underground work sites in which heavy equipment is used: mining, mine maintenance, and construction (EC: 27-658kg/m super(3)). Intermediate exposure levels were generally reported for above-ground (semi-) enclosed areas in which smaller equipment was run: mechanics in a shop, emergency workers in fire stations, distribution workers at a dock, and workers loading/unloading inside a ferry (generally: EC<50kg/m super(3)). Lowest levels were reported for enclosed areas separated from the source, such as drivers and train crew, or outside, such as surface mining, parking attendants, vehicle testers, utility service workers, surface construction and airline ground personnel (EC<25kg/m super(3)). The other agents showed a similar pattern. Determinants of exposure reported for enclosed situations were ventilation and exhaust after treatment devices. Reported DE exposure levels were highest for underground mining and construction, intermediate for working in above-ground (semi-) enclosed areas and lowest for working outside or separated from the source. The presented data can be used as a basis for assessing occupational exposure in population-based epidemiological studies and guide future exposure assessment efforts for industrial hygiene and epidemiological studies.Journal of Exposure Science and Environmental Epidemiology (2009) 19, 443-457; doi:10.1038/jes.2009.21; published online 11 March 2009 JF - Journal of Exposure Science and Environmental Epidemiology AU - Pronk, Anjoeka AU - Coble, Joseph AU - Stewart, Patricia A AD - aDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 443 EP - 457 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 19 IS - 5 SN - 1559-0631, 1559-0631 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Pollution Abstracts KW - Particulate matter KW - Carcinogens KW - Nitrogen dioxide KW - Workers KW - Personnel KW - Railroads KW - airlines KW - Exhaust emissions KW - Nitrogen oxides KW - Mines KW - Epidemiology KW - Literature reviews KW - Nitric oxide KW - Mining KW - Diesel engines KW - Nitrogen KW - Ventilation KW - Particulates KW - Unloading KW - Carbon monoxide KW - oxides KW - Occupational exposure KW - Fires KW - Data processing KW - Maintenance KW - Exhausts KW - Photochemicals KW - Reviews KW - Diesel KW - Hygiene KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20941095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Occupational+exposure+to+diesel+engine+exhaust%3A+A+literature+review&rft.au=Pronk%2C+Anjoeka%3BCoble%2C+Joseph%3BStewart%2C+Patricia+A&rft.aulast=Pronk&rft.aufirst=Anjoeka&rft.date=2009-07-01&rft.volume=19&rft.issue=5&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2009.21 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Fires; Data processing; Ventilation; Particulate matter; Carcinogens; Mines; Exhausts; Carbon monoxide; Unloading; Nitrogen dioxide; Workers; Literature reviews; Epidemiology; Personnel; oxides; Diesel; Nitric oxide; Hygiene; Occupational exposure; Nitrogen; Particulates; Nitrogen oxides; Maintenance; Photochemicals; airlines; Reviews; Railroads; Mining; Diesel engines; Exhaust emissions DO - http://dx.doi.org/10.1038/jes.2009.21 ER - TY - JOUR T1 - NIAID workshop on immunity to malaria: addressing immunological challenges AN - 20934946; 10986644 JF - Nature Immunology AU - Augustine, Alison Deckhut AU - Hall, B Fenton AU - Leitner, Wolfgang W AU - Mo, Annie X AU - Wali, Tonu M AU - Fauci, Anthony S AD - Alison Deckhut Augustine, B. Fenton Hall, Wolfgang W. Leitner, Annie X. Mo, Tonu M. Wali and Anthony S. Fauci are with the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. fauci[AT]niaid.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 673 EP - 678 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 10 IS - 7 SN - 1529-2908, 1529-2908 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Human diseases KW - Conferences KW - Immunology KW - Malaria KW - Immunity KW - Public health KW - K 03350:Immunology KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20934946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Immunology&rft.atitle=NIAID+workshop+on+immunity+to+malaria%3A+addressing+immunological+challenges&rft.au=Augustine%2C+Alison+Deckhut%3BHall%2C+B+Fenton%3BLeitner%2C+Wolfgang+W%3BMo%2C+Annie+X%3BWali%2C+Tonu+M%3BFauci%2C+Anthony+S&rft.aulast=Augustine&rft.aufirst=Alison&rft.date=2009-07-01&rft.volume=10&rft.issue=7&rft.spage=673&rft.isbn=&rft.btitle=&rft.title=Nature+Immunology&rft.issn=15292908&rft_id=info:doi/10.1038%2Fni0709-673 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Human diseases; Conferences; Immunology; Malaria; Public health; Immunity DO - http://dx.doi.org/10.1038/ni0709-673 ER - TY - JOUR T1 - Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse AN - 20930259; 10988488 AB - X-linked juvenile retinoschisis (XLRS) is a neurodevelopmental abnormality caused by retinoschisin gene mutations. XLRS is characterized by splitting through the retinal layers and impaired synaptic transmission of visual signals resulting in impaired acuity and a propensity to retinal detachment. Several groups have treated murine retinoschisis models successfully using adeno-associated virus (AAV) vectors. Owing to the fragile nature of XLRS retina, translating this therapy to the clinic may require an alternative to invasive subretinal vector administration. Here we show that all layers of the retinoschisin knockout (Rs1-KO) mouse retina can be transduced efficiently with AAV vectors administered by simple vitreous injection. Retinoschisin expression was restricted to the neuroretina using a new vector that uses a 3.5-kb human retinoschisin promoter and an AAV type 8 capsid. Intravitreal administration to Rs1-KO mice resulted in robust retinoschisin expression with a retinal distribution similar to that observed in wild-type retina, including the expression by the photoreceptors lying deep in the retina. No off-target expression was observed. Rs1-KO mice treated with this vector showed a decrease in the schisis cavities and had improved retinal signaling evaluated by recording the electroretinogram 11-15 weeks after the application.Gene Therapy (2009) 16, 916-926; doi:10.1038/gt.2009.61; published online 21 May 2009 JF - Gene Therapy AU - Park, T K AU - Wu, Z AU - Kjellstrom, S AU - Zeng, Y AU - Bush, R A AU - Sieving, P A AU - Colosi, P AD - Section for translational Research in Retinal and Macular Degeneration (STRRMD), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), Bethesda, MD, USA Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 916 EP - 926 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 16 IS - 7 SN - 0969-7128, 0969-7128 KW - Genetics Abstracts; Virology & AIDS Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Capsids KW - Cavities KW - Retina KW - Gene therapy KW - Point mutation KW - X chromosome KW - Acuity KW - Adeno-associated virus KW - Photoreceptors KW - Splitting KW - Expression vectors KW - Promoters KW - retinoschisis KW - Electroretinograms KW - Synaptic transmission KW - Signal transduction KW - W 30905:Medical Applications KW - V 22410:Animal Diseases KW - N3 11003:Developmental neuroscience KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20930259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Intravitreal+delivery+of+AAV8+retinoschisin+results+in+cell+type-specific+gene+expression+and+retinal+rescue+in+the+Rs1-KO+mouse&rft.au=Park%2C+T+K%3BWu%2C+Z%3BKjellstrom%2C+S%3BZeng%2C+Y%3BBush%2C+R+A%3BSieving%2C+P+A%3BColosi%2C+P&rft.aulast=Park&rft.aufirst=T&rft.date=2009-07-01&rft.volume=16&rft.issue=7&rft.spage=916&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2009.61 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Capsids; Cavities; Gene therapy; Retina; X chromosome; Point mutation; Acuity; Splitting; Photoreceptors; Expression vectors; retinoschisis; Promoters; Electroretinograms; Synaptic transmission; Signal transduction; Adeno-associated virus DO - http://dx.doi.org/10.1038/gt.2009.61 ER - TY - JOUR T1 - Dequalinium, a New Inhibitor of Mycobacterium tuberculosis Mycothiol Ligase Identified by High-Throughput Screening AN - 20766136; 10291435 AB - Mycothiol ligase (MshC) is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol that is unique to actinomycetes and whose primary role is to maintain intracellular redox balance and remove toxins. MshC catalyzes the adenosine triphosphate (ATP)a[Euro'dependent condensation of cysteine and glucosamine-inositol (GI) to produce cysteine-glucosamine-inositol (CGI). MshC is essential to Mycobacterium tuberculosis and therefore represents an attractive target for chemotherapeutic intervention. A screening protocol was developed to identify MshC inhibitors based on quantification of residual ATP using a coupled luminescent assay. The protocol was used to screen a library of 3100 compounds in a 384-well plate format (Za[Euro[ampersand]sup2[semicolon] appt[yen 0.65). Fifteen hits (0.48%) were identified from the screen, and 2 hits were confirmed in a secondary assay that measures production of CGI. The structures of both hits contain N-substituted quinolinium moieties, and the more potent of the 2a[Euro'namely, dequalinium chloridea[Euro'inhibits MshC with an IC sub(50) value of 24 A plus or minus 1 A mu M. Further studies showed dequalinium to be an ATP-competitive inhibitor of MshC, to bind MshC with a K sub(D) of 0.22 A mu M, and to inhibit the growth of M. tuberculosis under aerobic and anaerobic conditions with minimum inhibitory and anaerobic bactericidal concentrations of 1.2 and 0.3 A mu g/mL, respectively. The screening protocol described is robust and has enabled the identification of new MshC inhibitors. (Journal of Biomolecular Screening 2009:643-652) JF - Journal of Biomolecular Screening AU - Gutierrez-Lugo, Maria-Teresa AU - Baker, Heather AU - Shiloach, Joseph AU - Boshoff, Helena AU - Bewley, Carole A AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, caroleb@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 643 EP - 652 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 14 IS - 6 SN - 1087-0571, 1087-0571 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - competitive inhibitor KW - luminescent assay KW - mycothiol biosynthesis KW - screening KW - small molecular weight thiol KW - ATP KW - Enzymes KW - Anaerobic conditions KW - Toxins KW - Mycothiol KW - Cysteine KW - Molecular weight KW - Thiols KW - Tuberculosis KW - Condensation KW - high-throughput screening KW - Actinomycetes KW - Mycobacterium tuberculosis KW - W 30915:Pharmaceuticals & Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20766136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Dequalinium%2C+a+New+Inhibitor+of+Mycobacterium+tuberculosis+Mycothiol+Ligase+Identified+by+High-Throughput+Screening&rft.au=Gutierrez-Lugo%2C+Maria-Teresa%3BBaker%2C+Heather%3BShiloach%2C+Joseph%3BBoshoff%2C+Helena%3BBewley%2C+Carole+A&rft.aulast=Gutierrez-Lugo&rft.aufirst=Maria-Teresa&rft.date=2009-07-01&rft.volume=14&rft.issue=6&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057109335743 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cysteine; Molecular weight; Thiols; Enzymes; ATP; high-throughput screening; Condensation; Tuberculosis; Anaerobic conditions; Toxins; Actinomycetes; Mycothiol; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1177/1087057109335743 ER - TY - JOUR T1 - Concomitant Use of Prescription Drugs and Dietary Supplements in Ambulatory Elderly People AN - 20758995; 10206967 AB - OBJECTIVES: To analyze baseline data on concomitant use of prescription drugs and dietary supplements in elderly people from the Ginkgo Evaluation of Memory (GEM) Study, in which information was collected on all drugs and supplements used by participant.DESIGN: Cross-sectional correlation analysis.SETTING: GEM Study sites in California, Maryland, North Carolina, and Pennsylvania.PARTICIPANTS: Three thousand seventy ambulatory individuals aged 75 and older enrolled between September 2000 and June 2002.MEASUREMENTS: Use of prescription drugs and dietary supplements identified through bottles brought to the clinic.RESULTS: Almost three-quarters (74.2%) of the cohort combined use of at least one prescription drug and one dietary supplement, with 32.5% using three or more prescription drugs and three or more supplements. The 15 most-prevalent prescription drugs exhibited substantial concomitant use with dietary supplements, ranging from 77.6% for diuretics to 93.6% for estrogen preparations. Although supplements were taken concomitantly with all classes of prescription drugs, the use of supplements was more likely in individuals using nonsteroidal anti-inflammatory drugs, thyroid drugs, and estrogens. The use of drugs for diabetes mellitus was negatively associated with the use of supplements, with most of this attributed to low use in those taking multivitamins, glucosamine and chondroitin, and echinacea.CONCLUSION: There is substantial concomitant use of prescription drugs and dietary supplements in elderly people. Further investigations are needed to define the clinical importance of this concomitant use, especially in elderly patients who consume multiple prescription drugs or have experienced an adverse event secondary to their prescription medications. JF - Journal of the American Geriatrics Society AU - Nahin, Richard L AU - Pecha, Monica AU - Welmerink, Diana B AU - Sink, Kaycee AU - DeKosky, Steven T AU - Fitzpatrick, Annette L AD - *National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1197 EP - 1205 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK VL - 57 IS - 7 SN - 0002-8614, 0002-8614 KW - Health & Safety Science Abstracts KW - USA, North Carolina KW - dietary supplements KW - Thyroid KW - Ginkgo KW - diabetes mellitus KW - antiinflammatory agents KW - USA, California KW - elderly KW - Drugs KW - USA, Maryland KW - Side effects KW - estrogens KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20758995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Concomitant+Use+of+Prescription+Drugs+and+Dietary+Supplements+in+Ambulatory+Elderly+People&rft.au=Nahin%2C+Richard+L%3BPecha%2C+Monica%3BWelmerink%2C+Diana+B%3BSink%2C+Kaycee%3BDeKosky%2C+Steven+T%3BFitzpatrick%2C+Annette+L&rft.aulast=Nahin&rft.aufirst=Richard&rft.date=2009-07-01&rft.volume=57&rft.issue=7&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2009.02329.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Ginkgo; USA, Maryland; USA, California; USA, North Carolina; Drugs; dietary supplements; elderly; estrogens; Side effects; antiinflammatory agents; diabetes mellitus; Thyroid DO - http://dx.doi.org/10.1111/j.1532-5415.2009.02329.x ER - TY - JOUR T1 - Infections in Patients With Aplastic Anemia AN - 20747845; 10185784 AB - Infection is a major cause of death in patients with aplastic anemia (AA). There are differences between the immunocompromised state of a patient with AA and the patient who is neutropenic due to chemotherapy and this leads to a difference in the infections that they incur. Prolonged neutropenia is one of the largest risk factors for the development of infections with the invasive mycoses and bacteria. Recovery from neutropenia is directly related to survival, and supportive care plays a large role in protection while the patient is in a neutropenic state. The most common invasive mycoses include the Aspergillus species, Zygomycetes, Candida spp., and Fusarium spp. Bacterial infections that are seen in patients with AA include gram-positive coagulase-negative Staphylococcus species, Enterococcus, Staphylococus aureus, Clostridium spp., Micrococcus, alpha-hemolytic streptococci, Listeria monocytogenes, and Bacillus cereus. Gram-negative infections including gram-negative bacilli, Escherichia coli, Salmonella, Bacteroides fragilis, Klebsiella oxytoca, Klebsiella pneumonia, Aeromonas hydrophilia, Pseudomonas aeruginosa, and Vibrio vulnificus. Viral infections are much less common but include those that belong to the Herpesviridae family, community-acquired respiratory viral infection, and the viral hepatitides A, B, and C. Evidence of the parasite Strongyloides stercoralis has also been documented. This review discusses the major invasive fungal infections, bacterial pathogens, parasites, and viral infections that are found in patients with AA who are treated with immunosuppressive therapy. The specific immune impairment and current treatment parameters for each of these classes of infection will also be discussed. JF - Seminars in Hematology AU - Valdez, Jessica M AU - Scheinberg, Phillip AU - Young, Neal S AU - Walsh, Thomas J AD - Howard Hughes Medical Institute-National Institutes of Health Research Scholars Program, Bethesda, MD, walsht@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 269 EP - 276 PB - W.B. Saunders Co. VL - 46 IS - 3 SN - 0037-1963, 0037-1963 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Fusarium KW - Clostridium KW - Parasites KW - Chemotherapy KW - Bacillus cereus KW - Survival KW - Aspergillus KW - Infection KW - Immunosuppressive agents KW - Aeromonas KW - Strongyloides stercoralis KW - Vibrio vulnificus KW - Risk factors KW - Escherichia coli KW - Micrococcus KW - Pseudomonas aeruginosa KW - Listeria monocytogenes KW - Bacteroides fragilis KW - Staphylococcus KW - Candida KW - Pathogens KW - Klebsiella KW - Neutropenia KW - Gram-negative bacilli KW - Reviews KW - Enterococcus KW - Klebsiella oxytoca KW - Herpesviridae KW - Aplastic anemia KW - Salmonella KW - Pneumonia KW - Zygomycetes KW - A 01360:Plant Diseases KW - J 02400:Human Diseases KW - V 22400:Human Diseases KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20747845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Hematology&rft.atitle=Infections+in+Patients+With+Aplastic+Anemia&rft.au=Valdez%2C+Jessica+M%3BScheinberg%2C+Phillip%3BYoung%2C+Neal+S%3BWalsh%2C+Thomas+J&rft.aulast=Valdez&rft.aufirst=Jessica&rft.date=2009-07-01&rft.volume=46&rft.issue=3&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Hematology&rft.issn=00371963&rft_id=info:doi/10.1053%2Fj.seminhematol.2009.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Parasites; Neutropenia; Gram-negative bacilli; Reviews; Chemotherapy; Risk factors; Survival; Pathogens; Aplastic anemia; Infection; Immunosuppressive agents; Pneumonia; Bacteroides fragilis; Clostridium; Fusarium; Listeria monocytogenes; Staphylococcus; Candida; Bacillus cereus; Aspergillus; Klebsiella; Aeromonas; Vibrio vulnificus; Strongyloides stercoralis; Enterococcus; Escherichia coli; Micrococcus; Herpesviridae; Klebsiella oxytoca; Pseudomonas aeruginosa; Salmonella; Zygomycetes DO - http://dx.doi.org/10.1053/j.seminhematol.2009.03.008 ER - TY - JOUR T1 - Advances and Challenges in Infectious Diseases Supportive Care of Patients With Hematologic Malignancies, Hematopoietic Stem Cell Transplantation, and Severe Aplastic Anemia AN - 20747821; 10185778 AB - Infectious diseases are important causes of morbidity and mortality in immunocompromised patients with hematological malignancies, severe aplastic anemia (SAA), and myelodysplasia. Major advances in infectious diseases supportive care have been critical to improving the outcome of patients suffering from these life- threatening diseases. Advances in diagnosis, treatment, and prevention of life-threatening infections have reduced morbidity and mortality, improved quality of life, and enabled the use of potentially curative chemotherapy, radiation, hematopoietic stem cell transplantation (HSCT), and immunosuppressive therapy to patients battling these devastating diseases. Despite these advances, the continued development of antimicrobial resistance, emergence of new pathogens, and the evolution of host factors present evolving challenges to the successful management of infectious complications in this expanding patient population. JF - Seminars in Hematology AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 191 EP - 197 PB - W.B. Saunders Co. VL - 46 IS - 3 SN - 0037-1963, 0037-1963 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Mortality KW - Drug resistance KW - stem cell transplantation KW - Chemotherapy KW - Pathogens KW - Infection KW - Immunosuppressive agents KW - Morbidity KW - Malignancy KW - Radiation KW - Infectious diseases KW - Immunocompromised hosts KW - myelodysplasia KW - Aplastic anemia KW - Evolution KW - Quality of life KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20747821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Hematology&rft.atitle=Advances+and+Challenges+in+Infectious+Diseases+Supportive+Care+of+Patients+With+Hematologic+Malignancies%2C+Hematopoietic+Stem+Cell+Transplantation%2C+and+Severe+Aplastic+Anemia&rft.au=Walsh%2C+Thomas+J&rft.aulast=Walsh&rft.aufirst=Thomas&rft.date=2009-07-01&rft.volume=46&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Hematology&rft.issn=00371963&rft_id=info:doi/10.1053%2Fj.seminhematol.2009.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Chemotherapy; stem cell transplantation; Drug resistance; Pathogens; Infection; Immunosuppressive agents; Morbidity; Malignancy; Infectious diseases; Radiation; Immunocompromised hosts; myelodysplasia; Aplastic anemia; Evolution; Quality of life DO - http://dx.doi.org/10.1053/j.seminhematol.2009.05.001 ER - TY - JOUR T1 - Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro AN - 20745434; 9352855 AB - Microglial activation has been implicated in many astrogliosis-related pathological conditions including astroglioma; however, the detailed mechanism is not clear. In this study, we used primary enriched microglia and astrocyte cultures to determine the role of microglial prostaglandin E sub(2) (PGE sub(2)) in the proliferation of astrocytes. The proliferation of astrocytes was measured by BrdU incorporation. The level of PGE sub(2) was measured by ELISA method. Pharmacological inhibition or genetic ablation of COX-2 in microglia were also applied in this study. We found that proliferation of astrocytes increased following lipopolysaccharide (LPS) treatment in the presence of microglia. Furthermore, increased proliferation of astrocytes was observed in the presence of conditioned media from LPS-treated microglia. The potential involvement of microglial PGE sub(2) in enhanced astrocyte proliferation was suggested by the findings that PGE sub(2) production and COX-2 expression in microglia were increased by LPS treatment. In addition, activated microglia-induced increases in astrocyte proliferation were blocked by the PGE sub(2) antagonist AH6809, COX-2 selective inhibitor DuP-697 or by genetic knockout of microglial COX-2. These findings were further supported by the finding that addition of PGE sub(2) to the media significantly induced astrocyte proliferation. These results indicate that microglial PGE sub(2) plays an important role in astrocyte proliferation, identifying PGE sub(2) as a key neuroinflammatory molecule that triggers the pathological response related to uncontrollable astrocyte proliferation. These findings are important in elucidating the role of activated microglia and PGE sub(2) in astrocyte proliferation and in suggesting a potential avenue in the use of anti-inflammatory agents for the therapy of astroglioma. JF - Toxicology and Applied Pharmacology AU - Zhang, D AU - Hu, X AU - Qian, L AU - Wilson, B AU - Lee, C AU - Flood, P AU - Langenbach, R AU - Hong, J S AD - National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA, hong3@niehs.nih.gov Y1 - 2009/07/01/ PY - 2009 DA - 2009 Jul 01 SP - 64 EP - 70 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 238 IS - 1 SN - 0041-008X, 0041-008X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Cyclooxygenase-2 KW - Enzyme-linked immunosorbent assay KW - Astrocytes KW - Lipopolysaccharides KW - Prostaglandin E2 KW - Microglia KW - Media (selective) KW - Antiinflammatory agents KW - Inflammation KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20745434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Prostaglandin+E2+released+from+activated+microglia+enhances+astrocyte+proliferation+in+vitro&rft.au=Zhang%2C+D%3BHu%2C+X%3BQian%2C+L%3BWilson%2C+B%3BLee%2C+C%3BFlood%2C+P%3BLangenbach%2C+R%3BHong%2C+J+S&rft.aulast=Zhang&rft.aufirst=D&rft.date=2009-07-01&rft.volume=238&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Enzyme-linked immunosorbent assay; Astrocytes; Lipopolysaccharides; Prostaglandin E2; Microglia; Antiinflammatory agents; Media (selective); Inflammation DO - http://dx.doi.org/10.1016/j.taap.2009.04.015 ER - TY - JOUR T1 - NCBI Peptidome: a new public repository for mass spectrometry peptide identifications AN - 20697272; 10285675 JF - Nature Biotechnology AU - Slotta, Douglas J AU - Barrett, Tanya AU - Edgar, Ron AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA, peptidome@ncbi.nlm.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 600 EP - 601 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 27 IS - 7 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts KW - Mass spectroscopy KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20697272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=NCBI+Peptidome%3A+a+new+public+repository+for+mass+spectrometry+peptide+identifications&rft.au=Slotta%2C+Douglas+J%3BBarrett%2C+Tanya%3BEdgar%2C+Ron&rft.aulast=Slotta&rft.aufirst=Douglas&rft.date=2009-07-01&rft.volume=27&rft.issue=7&rft.spage=600&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt0709-600 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mass spectroscopy DO - http://dx.doi.org/10.1038/nbt0709-600 ER - TY - JOUR T1 - Axonal Mitochondrial Clusters Containing Mutant SOD1 in Transgenic Models of ALS AN - 20687635; 10134976 AB - We studied the subcellular distribution of mitochondria and superoxide dismutase-1 (SOD1) in whole mounts of microdissected motor axons of rats expressing the ALS-linked SOD1-G93A mutation. The rationale was to determine whether physical interactions between the enzyme and mitochondria were linked to the axonopathy of motor fibers occurring in amyotrophic lateral sclerosis (ALS). Mitochondria and SOD1 displayed a homogeneous distribution along motor axons both in nontransgenic rats and in those overexpressing wild-type SOD1. In contrast, axons from SOD1-G93A rats (older than 35 days) showed accumulation of mitochondria in discrete clusters located at regular intervals. Most of SOD1 immunoreactivity was enriched in these clusters and coloca-lized with mitochondria, suggesting a recruitment of SOD1-G93A to the organelle. The SOD1/mitochondrial clusters were abundant in motor axons but scarcely seen in sensory axons. Clusters also were stained for neuronal nitric oxide synthase, nitrotyrosine, and cytochrome c. The later also was detected surrounding clusters. Ubiquitin colocalized with clusters only at late stages of the disease. The cytoskeleton was not overtly altered in clusters. These results suggest that mutant SOD1 and defective mitochondria create localized dysfunctional domains in motor axons, which may lead to progressive axonopathy in ALS. JF - Antioxidants and Redox Signaling AU - Sotelo-Silveira, J R AU - Lepanto, P AU - Elizondo, V AU - Horjales, S AU - Palacios, F AU - Martinez-Palma, L AU - Marin, M AU - Beckman, J S AU - Barbeito, L AD - Laboratory of Molecular Technology, ATP, SAIC-National Cancer Institute, Frederick, MD, USA, soteloj@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1535 EP - 1545 VL - 11 IS - 7 SN - 1523-0864, 1523-0864 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - nitrotyrosine KW - Antioxidants KW - Sensory neurons KW - Recruitment KW - Enzymes KW - Mitochondria KW - Nitric-oxide synthase KW - Cytoskeleton KW - Motor neurons KW - Fibers KW - Amyotrophic lateral sclerosis KW - Cytochrome c KW - Superoxide dismutase KW - Superoxide KW - Immunoreactivity KW - Axons KW - Organelles KW - Mutation KW - Signal transduction KW - Ubiquitin KW - W 30910:Imaging KW - N3 11008:Neurochemistry KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20687635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+and+Redox+Signaling&rft.atitle=Axonal+Mitochondrial+Clusters+Containing+Mutant+SOD1+in+Transgenic+Models+of+ALS&rft.au=Sotelo-Silveira%2C+J+R%3BLepanto%2C+P%3BElizondo%2C+V%3BHorjales%2C+S%3BPalacios%2C+F%3BMartinez-Palma%2C+L%3BMarin%2C+M%3BBeckman%2C+J+S%3BBarbeito%2C+L&rft.aulast=Sotelo-Silveira&rft.aufirst=J&rft.date=2009-07-01&rft.volume=11&rft.issue=7&rft.spage=1535&rft.isbn=&rft.btitle=&rft.title=Antioxidants+and+Redox+Signaling&rft.issn=15230864&rft_id=info:doi/10.1089%2Fars.2009.2614 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Antioxidants; nitrotyrosine; Sensory neurons; Recruitment; Mitochondria; Enzymes; Cytoskeleton; Nitric-oxide synthase; Fibers; Motor neurons; Cytochrome c; Amyotrophic lateral sclerosis; Superoxide dismutase; Superoxide; Immunoreactivity; Axons; Organelles; Mutation; Ubiquitin; Signal transduction DO - http://dx.doi.org/10.1089/ars.2009.2614 ER - TY - JOUR T1 - Predictors of fasting serum insulin and glucose and the risk of pancreatic cancer in smokers AN - 20651285; 9408124 AB - Objectives: A history of type 2 diabetes is one of few consistent risk factors for pancreatic cancer. Potentially modifiable factors related to fasting insulin and glucose concentrations may influence pancreatic cancer risk. Methods: Multiple linear regression models were used to identify anthropometric, clinical, behavioral, and dietary factors associated with fasting insulin and glucose in a subcohort of non-diabetics in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n = 366). Hazards ratios (HRs) and 95% confidence intervals (CIs) were calculated among the larger cohort (n = 27,035). Results: During follow-up (median 16.1 years), 305 participants developed pancreatic cancer. Fasting insulin and/or glucose were positively associated with body mass index (BMI), height, and dietary total and saturated fat and inversely associated with serum high-density lipoprotein cholesterol (HDL) and dietary available carbohydrates, sucrose, and alcohol. Comparing highest to lowest quintiles, total fat (HR = 1.54, 95% CI 1.05-2.25, p-trend = 0.01) and saturated fat (HR = 1.38, 95% CI 0.97-1.98, p-trend = 0.06) were positively associated and available carbohydrates (HR = 0.63, 95% CI 0.44-0.90, p-trend = 0.01), particularly sucrose (HR = 0.62, 95% CI 0.43-0.89, p-trend = 0.09), were inversely associated with risk of pancreatic cancer. BMI, HDL, height, and alcohol were not associated with pancreatic cancer risk. Conclusion: Dietary fat is associated with higher fasting insulin concentrations and may increase pancreatic cancer risk in smokers. JF - Cancer Causes & Control AU - Meinhold, Cari L AU - Gonzalez, Amy Berrington AU - Albanes, Demetrius AU - Weinstein, Stephanie J AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Stolzenberg-Solomon, Rachael Z Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 681 EP - 690 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 20 IS - 5 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Diets KW - Alcohol KW - Historical account KW - pancreatic cancer KW - diabetes mellitus KW - body mass KW - insulin KW - prevention KW - Carbohydrates KW - cholesterol KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20651285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Predictors+of+fasting+serum+insulin+and+glucose+and+the+risk+of+pancreatic+cancer+in+smokers&rft.au=Meinhold%2C+Cari+L%3BGonzalez%2C+Amy+Berrington%3BAlbanes%2C+Demetrius%3BWeinstein%2C+Stephanie+J%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Meinhold&rft.aufirst=Cari&rft.date=2009-07-01&rft.volume=20&rft.issue=5&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-008-9281-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Historical account; Alcohol; diabetes mellitus; pancreatic cancer; body mass; insulin; prevention; Carbohydrates; cholesterol; Cancer DO - http://dx.doi.org/10.1007/s10552-008-9281-z ER - TY - JOUR T1 - Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health Study AN - 20632457; 9356576 AB - We investigated the association of dietary -tocopherol, -tocopherol and supplemental vitamin E intake with the risk of esophageal squamous cell carcinoma (n = 158), esophageal adenocarcinoma (n = 382), gastric cardia adenocarcinoma (n = 320) and gastric noncardia adenocarcinoma (GNCA; n = 327) in the NIH-AARP Diet and Health Study, a cohort of approximately 500,000 people. Data on dietary and supplemental vitamin E intake were collected using a validated questionnaire at baseline and were analyzed using Cox regression models. Intakes were analyzed as continuous variables and as quartiles. For dietary -tocopherol, we found some evidence of association with decreased esophageal squamous cell carcinoma and increased esophageal adenocarcinoma risk in the continuous analyses, with adjusted hazard ratios and 95% confidence intervals of 0.90 (0.81-0.99) and 1.05 (1.00-1.11), respectively, per 1.17 mg (half the interquartile range) increased intake. However, in quartile analyses, the p value for trend was nonsignificant for both these cancers. There was no association between dietary -tocopherol and gastric cardia adenocarcinoma or GNCA. We observed no statistically significant associations with -tocopherol. For supplemental vitamin E, the results were mainly null, except for a significantly lower risk of GNCA with higher doses of supplemental vitamin E. An increase of 71 mg/day (half the interquartile range) in supplemental vitamin E had an hazard ratio (95% confidence interval) of 0.92 (0.85-1.00) and the p value for trend in the quartile analysis was 0.015. JF - International Journal of Cancer AU - Carman, Sarah AU - Kamangar, Farin AU - Freedman, Neal D AU - Wright, Margaret E AU - Dawsey, Sanford M AU - Dixon, L Beth AU - Subar, Amy AU - Schatzkin, Arthur AU - Abnet, Christian C AD - NEB/DCEG, National Cancer Institute, Bethesda, MD, kamangaf@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 165 EP - 170 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 125 IS - 1 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Diets KW - vitamins KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20632457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Vitamin+E+intake+and+risk+of+esophageal+and+gastric+cancers+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Carman%2C+Sarah%3BKamangar%2C+Farin%3BFreedman%2C+Neal+D%3BWright%2C+Margaret+E%3BDawsey%2C+Sanford+M%3BDixon%2C+L+Beth%3BSubar%2C+Amy%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian+C&rft.aulast=Carman&rft.aufirst=Sarah&rft.date=2009-07-01&rft.volume=125&rft.issue=1&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24342 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; vitamins; Cancer DO - http://dx.doi.org/10.1002/ijc.24342 ER - TY - JOUR T1 - Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer AN - 20629701; 9356573 AB - Family history (FH) of lung cancer is an established risk factor for lung cancer, but the modifying effect of smoking in relatives has been rarely examined. Also, the role of FH of nonmalignant lung diseases on lung cancer risk is not well known. We examined the role of FH of cancer and nonmalignant lung diseases in lung cancer risk overall, and by personal smoking, FH of smoking and histology in 1,946 cases and 2,116 population-based controls within the Environment And Genetics in Lung cancer Etiology (EAGLE) study. Odds ratios (ORs) and 95% CI from logistic regression were calculated adjusting for age, gender, residence, education and cigarette smoking. FH of lung cancer in any family member was associated with increased lung cancer risk (OR = 1.57, 95% CI = 1.25-1.98). The odds associated with fathers', mothers' and siblings' history of lung cancer were 1.41, 2.14 and 1.53, respectively. The associations were generally stronger in never smokers, younger subjects and for the adenocarcinoma and squamous cell carcinoma subtypes. FH of chronic bronchitis and pneumonia was associated with increased (OR = 1.49, 95% CI = 1.23-1.80) and decreased (OR = 0.73, 95% CI = 0.61-0.87) lung cancer risk, respectively. FH of lung cancer and nonmalignant lung diseases affected lung cancer risk independently, and did not appear to be modified by FH of smoking. JF - International Journal of Cancer AU - Gao, Ying AU - Goldstein, Alisa M AU - Consonni, Dario AU - Pesatori, Angela C AU - Wacholder, Sholom AU - Tucker, Margaret A AU - Caporaso, Neil E AU - Goldin, Lynn AU - Landi, Maria Teresa AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, landim@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 146 EP - 152 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 125 IS - 1 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Genetics KW - Historical account KW - Education KW - Age KW - Etiology KW - Histology KW - Cigarette smoking KW - Gender KW - siblings KW - Cancer KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20629701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Family+history+of+cancer+and+nonmalignant+lung+diseases+as+risk+factors+for+lung+cancer&rft.au=Gao%2C+Ying%3BGoldstein%2C+Alisa+M%3BConsonni%2C+Dario%3BPesatori%2C+Angela+C%3BWacholder%2C+Sholom%3BTucker%2C+Margaret+A%3BCaporaso%2C+Neil+E%3BGoldin%2C+Lynn%3BLandi%2C+Maria+Teresa&rft.aulast=Gao&rft.aufirst=Ying&rft.date=2009-07-01&rft.volume=125&rft.issue=1&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24283 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Historical account; Genetics; Etiology; Age; Education; Histology; Gender; Cigarette smoking; siblings; Cancer; Lung cancer DO - http://dx.doi.org/10.1002/ijc.24283 ER - TY - JOUR T1 - Clinical implications of icaA and icaD genes in coagulase negative staphylococci and Staphylococcus aureus bacteremia in febrile neutropenic pediatric cancer patients AN - 20621473; 9331898 AB - Background Staphylococci are the most frequently isolated organisms from blood cultures of febrile neutropenic (FN) cancer patients. We aimed to define the nature of these isolates by studying the prevalence of icaA and icaD genes in coagulase-negative staphylococci (CoNS) and Staphylococcus aureus isolates in relation to clinical and microbiological features. Procedure Fifty-five CoNS and S. aureus isolates from blood cultures of FN pediatric patients receiving chemotherapy were tested for slime production using Congo red agar plate test (CRA test), and for the presence of icaA and icaD genes by PCR. Results Of the CoNS isolates, eight were positive for ica genes, and three were slime positive/ica negative. A total of 11 (24.4%) cases of CoNS bacteremia were either ica genes or CRA test positive. There was a concordance between ica genes and CRA test positivity (P < 0.001). S. aureus isolates exhibited icaA and icaD genes more than CoNS isolates (P = 0.03). Vancomycin was significantly more prescribed in episodes of ica-positive cases (P = 0.029). Conclusions The results of the present study support the hypothesis that the ica genes are important virulence markers for clinically significant CoNS isolates, indicating their ability to produce slime. This could be used to assign a group with higher risk FN. On the other hand, absence of these genes may permit, along with other clinical criteria, the consideration of a low-risk FN episode and allow for safe early discharge. Pediatr Blood Cancer 2009; 52:824-828. JF - Pediatric Blood & Cancer AU - El-Mahallawy, Hadir A AU - Loutfy, Samah A AU - El-Wakil, Mohamed AU - El-Al, Abeer K Abd AU - Morcos, Hanaa AD - Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt, hadir38@hotmail.com Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 824 EP - 828 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 52 IS - 7 SN - 1545-5009, 1545-5009 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Blood culture KW - Agar KW - Pediatrics KW - Chemotherapy KW - Bacteremia KW - Cancer KW - Coagulase KW - Virulence KW - Neutropenia KW - Slimes KW - Risk factors KW - Polymerase chain reaction KW - Risk groups KW - Vancomycin KW - Staphylococcus aureus KW - G 07880:Human Genetics KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20621473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+Blood+%26+Cancer&rft.atitle=Clinical+implications+of+icaA+and+icaD+genes+in+coagulase+negative+staphylococci+and+Staphylococcus+aureus+bacteremia+in+febrile+neutropenic+pediatric+cancer+patients&rft.au=El-Mahallawy%2C+Hadir+A%3BLoutfy%2C+Samah+A%3BEl-Wakil%2C+Mohamed%3BEl-Al%2C+Abeer+K+Abd%3BMorcos%2C+Hanaa&rft.aulast=El-Mahallawy&rft.aufirst=Hadir&rft.date=2009-07-01&rft.volume=52&rft.issue=7&rft.spage=824&rft.isbn=&rft.btitle=&rft.title=Pediatric+Blood+%26+Cancer&rft.issn=15455009&rft_id=info:doi/10.1002%2Fpbc.21964 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Blood culture; Agar; Pediatrics; Chemotherapy; Bacteremia; Cancer; Virulence; Coagulase; Neutropenia; Slimes; Risk factors; Vancomycin; Risk groups; Polymerase chain reaction; Staphylococcus aureus DO - http://dx.doi.org/10.1002/pbc.21964 ER - TY - JOUR T1 - Applications of high-throughput genomics to antiviral research: Evasion of antiviral responses and activation of inflammation during fulminant RNA virus infection AN - 20621429; 9352905 AB - Host responses can contribute to the severity of viral infection, through the failure of innate antiviral mechanisms to recognize and restrict the pathogen, the development of intense systemic inflammation leading to circulatory failure or through tissue injury resulting from overly exuberant cell-mediated immune responses. High-throughput genomics methods are now being used to identify the biochemical pathways underlying ineffective or damaging host responses in a number of acute and chronic viral infections. This article reviews recent gene expression studies of 1918 H1N1 influenza and Ebola hemorrhagic fever in cell culture and animal models, focusing on how genomics experiments can be used to increase our understanding of the mechanisms that permit those viruses to cause rapidly overwhelming infection. Particular attention is paid to how evasion of type I IFN responses in infected cells might contribute to over-activation of inflammatory responses. Reviewing recent research and describing how future studies might be tailored to understand the relationship between the infected cell and its environment, this article discusses how the rapidly growing field of high-throughput genomics can contribute to a more complete understanding of severe, acute viral infections and identify novel targets for therapeutic intervention. JF - Antiviral Research AU - Kash, J C AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 33 North Drive, MSC 3203, Bethesda, MD 20892-3203, USA, kashj@niaid.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 10 EP - 20 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 83 IS - 1 SN - 0166-3542, 0166-3542 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Injuries KW - Animal models KW - Therapeutic applications KW - Ebola virus KW - Cell culture KW - RNA viruses KW - Pathogens KW - Inflammation KW - Gene expression KW - Influenza KW - Interferon KW - Immune response (cell-mediated) KW - Chronic infection KW - Hemorrhagic fever KW - genomics KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - G 07730:Development & Cell Cycle KW - N 14810:Methods KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20621429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Applications+of+high-throughput+genomics+to+antiviral+research%3A+Evasion+of+antiviral+responses+and+activation+of+inflammation+during+fulminant+RNA+virus+infection&rft.au=Kash%2C+J+C&rft.aulast=Kash&rft.aufirst=J&rft.date=2009-07-01&rft.volume=83&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2009.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Injuries; Animal models; Therapeutic applications; RNA viruses; Cell culture; Pathogens; Inflammation; Influenza; Gene expression; Interferon; Immune response (cell-mediated); Chronic infection; Hemorrhagic fever; genomics; Ebola virus DO - http://dx.doi.org/10.1016/j.antiviral.2009.04.004 ER - TY - JOUR T1 - Respiratory viruses and eosinophils: Exploring the connections AN - 20619469; 9352906 AB - In this review, we consider the role played by eosinophilic leukocytes in the pathogenesis and pathophysiology of respiratory virus infection. The vast majority of the available information on this topic focuses on respiratory syncytial virus (RSV; Family Paramyxoviridae, genus Pneumovirus), an important pediatric pathogen that infects infants worldwide. There is no vaccine currently available for RSV. A formalin-inactivated RSV vaccine used in a trial in the 1960s elicited immunopathology in response to natural RSV infection; this has been modeled experimentally, primarily in inbred mice and cotton rats. Eosinophils are recruited to the lung tissue in response to formalin-inactivated RSV vaccine antigens in humans and in experimental models, but they may or may not be involved in promoting the severe clinical sequelae observed. Pulmonary eosinophilia elicited in response to primary RSV infection has also been explored; this response is particularly evident in the youngest human infants and in neonatal mouse models. Although pulmonary eosinophilia is nearly always perceived in a negative light, the specific role played by virus-elicited eosinophils - negative, positive or neutral bystander - remain unclear. Lastly, we consider the data that focus on the role of eosinophils in promoting virus clearance and antiviral host defense, and conclude with a recent study that explores the role of eosinophils themselves as targets of virus infection. JF - Antiviral Research AU - Rosenberg, H F AU - Dyer, K D AU - Domachowske, J B AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States, hrosenberg@niaid.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1 EP - 9 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 83 IS - 1 SN - 0166-3542, 0166-3542 KW - Immunology Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Pneumovirus KW - Data processing KW - Complications KW - Pediatrics KW - Lung diseases KW - Animal models KW - Pathogens KW - Leukocytes (eosinophilic) KW - Infection KW - Paramyxoviridae KW - Clinical trials KW - Eosinophilia KW - Respiratory syncytial virus KW - Lung KW - Reviews KW - Inbreeding KW - Neonates KW - Vaccines KW - Infants KW - A 01340:Antibiotics & Antimicrobials KW - F 06905:Vaccines KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20619469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Respiratory+viruses+and+eosinophils%3A+Exploring+the+connections&rft.au=Rosenberg%2C+H+F%3BDyer%2C+K+D%3BDomachowske%2C+J+B&rft.aulast=Rosenberg&rft.aufirst=H&rft.date=2009-07-01&rft.volume=83&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2009.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Pediatrics; Complications; Animal models; Lung diseases; Leukocytes (eosinophilic); Pathogens; Infection; Eosinophilia; Clinical trials; Lung; Reviews; Inbreeding; Vaccines; Neonates; Infants; Respiratory syncytial virus; Pneumovirus; Paramyxoviridae DO - http://dx.doi.org/10.1016/j.antiviral.2009.04.005 ER - TY - JOUR T1 - Antiviral Therapy in Patients With Hematologic Malignancies, Transplantation, and Aplastic Anemia AN - 20215747; 10185781 AB - Advances in supportive care over the past two decades have decreased the morbidity and mortality attributed to opportunistic infections in immunocompromised patients, including those with hematologic malignancies, hematopoietic stem cell transplantation (HSCT), and aplastic anemia. Despite advances in antiviral therapy, opportunistic viral infections such as influenza, herpes simplex virus (HSV), varicella zoster virus (VZV), and cytomegalovirus (CMV) still cause significant morbidity and mortality in patients with compromised host defenses. Antiviral agents are key antimicrobials used for treatment and prophylaxis of viral infections in immunocompromised hosts. Currently, there are more than 40 antiviral agents approved for clinical use, but the majority of these agents are for the treatment of human immunodeficiency virus (HIV) or viral hepatitis. This review will focus on antiviral agents used for the treatment of herpesviruses (HSV, VZV, CMV), community-acquired respiratory viruses (influenza), and adenoviruses. Antiviral agents used for the treatment of HIV and viral hepatitis will not be addressed in this review. JF - Seminars in Hematology AU - Jancel, Timothy AU - Penzak, Scott R AD - Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD, jancelt@cc.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 230 EP - 247 PB - W.B. Saunders Co. VL - 46 IS - 3 SN - 0037-1963, 0037-1963 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Mortality KW - stem cell transplantation KW - Cytomegalovirus KW - Morbidity KW - Antimicrobial agents KW - Opportunist infection KW - Hepatitis KW - Influenza KW - Malignancy KW - Antiviral agents KW - Human immunodeficiency virus KW - Immunocompromised hosts KW - Varicella-zoster virus KW - Prophylaxis KW - Aplastic anemia KW - Herpes simplex virus KW - Varicella KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20215747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Hematology&rft.atitle=Antiviral+Therapy+in+Patients+With+Hematologic+Malignancies%2C+Transplantation%2C+and+Aplastic+Anemia&rft.au=Jancel%2C+Timothy%3BPenzak%2C+Scott+R&rft.aulast=Jancel&rft.aufirst=Timothy&rft.date=2009-07-01&rft.volume=46&rft.issue=3&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Hematology&rft.issn=00371963&rft_id=info:doi/10.1053%2Fj.seminhematol.2009.03.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; stem cell transplantation; Morbidity; Opportunist infection; Antimicrobial agents; Influenza; Hepatitis; Malignancy; Antiviral agents; Immunocompromised hosts; Prophylaxis; Aplastic anemia; Varicella; Human immunodeficiency virus; Varicella-zoster virus; Herpes simplex virus; Cytomegalovirus DO - http://dx.doi.org/10.1053/j.seminhematol.2009.03.004 ER - TY - JOUR T1 - Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality AN - 20185016; 10278273 AB - Using our recently disclosed 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one and 4,5-dihydroxy-1H- isoindole-1,3(2H)-dione integrase inhibitors, we report differential effects on inhibitory potency induced by introduction of an alpha -chiral center into a key aryl substituent. We show that introduction of the chiral center is uniformly deleterious to binding, with the (R)-enantiomer being more deleterious than the (S)-enantiomer. A greater enantiomeric difference in potency is shown by inhibitors that have restricted rotation of the aryl ring, with the larger difference being due to poorer potency of the (R)- enantiomer rather than higher potency of the (S)-enantiomer. The potency difference for enantiomers based on the isoindoline-1,3-dione ring system is less than for those derived from the isoindol-1-one ring system. Our findings provide useful information that should aid in understanding molecular binding interactions of DKA-derived IN inhibitors. JF - Bioorganic and Medicinal Chemistry AU - Zhao, Xue Zhi AU - Maddali, Kasthuraiah AU - Marchand, Christophe AU - Pommier, Yves AU - Burke, Terrence R AD - Laboratory of Medicinal, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, United States, tburke@helix.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 5318 EP - 5324 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 14 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Enantiomers KW - Human immunodeficiency virus 1 KW - Integrase KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20185016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Diketoacid-genre+HIV-1+integrase+inhibitors+containing+enantiomeric+arylamide+functionality&rft.au=Zhao%2C+Xue+Zhi%3BMaddali%2C+Kasthuraiah%3BMarchand%2C+Christophe%3BPommier%2C+Yves%3BBurke%2C+Terrence+R&rft.aulast=Zhao&rft.aufirst=Xue&rft.date=2009-07-01&rft.volume=17&rft.issue=14&rft.spage=5318&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2009.05.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Enantiomers; Integrase; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.bmc.2009.05.008 ER - TY - JOUR T1 - Epigenetic gene regulation in stem cells and correlation to cancer AN - 20183525; 10258093 AB - Through the classic study of genetics, much has been learned about the regulation and progression of human disease. Specifically, cancer has been defined as a disease driven by genetic alterations, including mutations in tumor-suppressor genes and oncogenes, as well as chromosomal abnormalities. However, the study of normal human development has identified that in addition to classical genetics, regulation of gene expression is also modified by 'epigenetic' alterations including chromatin remodeling and histone variants, DNA methylation, the regulation of polycomb group proteins, and the epigenetic function of non-coding RNA. These changes are modifications inherited during both meiosis and mitosis, yet they do not result in alterations of the actual DNA sequence. A number of biological questions are directly influenced by epigenetics, such as how does a cell know when to divide, differentiate or remain quiescent, and more importantly, what happens when these pathways become altered? Do these alterations lead to the development and/or progression of cancer? This review will focus on summarizing the limited current literature involving epigenetic alterations in the context of human cancer stems cells (CSCs). The extent to which epigenetic changes define cell fate, identity, and phenotype are still under intense investigation, and many questions remain largely unanswered. Before discussing epigenetic gene silencing in CSCs, the different classifications of stem cells and their properties will be introduced. This will be followed by an introduction to the different epigenetic mechanisms. Finally, there will be a discussion of the current knowledge of epigenetic modifications in stem cells, specifically what is known from rodent systems and established cancer cell lines, and how they are leading us to understand human stem cells. JF - Differentiation AU - Mathews, Lesley A AU - Crea, Francesco AU - Farrar, W L AD - Cancer Stem Cell Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles St., Building 560, Room 21-81, Frederick, MD 21702, USA, farrar@mail.ncifcrf.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1 EP - 17 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 78 IS - 1 SN - 0301-4681, 0301-4681 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Tumor suppressor genes KW - Histones KW - Chromatin remodeling KW - polycomb group proteins KW - Nucleotide sequence KW - non-coding RNA KW - Cancer KW - Tumor cell lines KW - Stem cells KW - Oncogenes KW - epigenetics KW - Meiosis KW - Reviews KW - Gene regulation KW - Mitosis KW - DNA methylation KW - Cell fate KW - Mutation KW - Gene silencing KW - W 30940:Products KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20183525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Differentiation&rft.atitle=Epigenetic+gene+regulation+in+stem+cells+and+correlation+to+cancer&rft.au=Mathews%2C+Lesley+A%3BCrea%2C+Francesco%3BFarrar%2C+W+L&rft.aulast=Mathews&rft.aufirst=Lesley&rft.date=2009-07-01&rft.volume=78&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Differentiation&rft.issn=03014681&rft_id=info:doi/10.1016%2Fj.diff.2009.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Histones; polycomb group proteins; Chromatin remodeling; Nucleotide sequence; non-coding RNA; Cancer; Stem cells; Tumor cell lines; Oncogenes; Meiosis; epigenetics; Mitosis; Gene regulation; Reviews; DNA methylation; Cell fate; Mutation; Gene silencing DO - http://dx.doi.org/10.1016/j.diff.2009.04.002 ER - TY - JOUR T1 - Toward preparation of antibody-based imaging probe libraries for dual-modality positron emission tomography and fluorescence imaging AN - 20154894; 10278260 AB - Two novel imaging agents trastuzumab-Cy5.5-CHX-u 1 and cetuximab-Cy7-CHX-u 2, bearing both a chelating moiety (CHX-u) for sequestering metallic radionuclides ( super(86)Y or super(111)In) and the near infrared dye Cy5.5/Cy7, were prepared by a novel modular synthetic strategy as examples of dual-labeled, antibody-based imaging probe library. Fluorescent microscopy illustrated that 1 and 2 strongly bind to HER2-expressing cancer cells (e.g., NIH3T3-HER2 super(+), SKOV-3) and to EGFR-expressing cancer cells (e.g., A431), respectively, thereby demonstrating that the functionality of the targeting moiety is conserved. Hence, the described novel synthesis strategy can be applied to engineer other tumor-targeted monoclonal antibody based probes for multimodality imaging. JF - Bioorganic and Medicinal Chemistry AU - Xu, Heng AU - Eck, Peter K AU - Baidoo, Kwamena E AU - Choyke, Peter L AU - Brechbiel, Martin W AD - Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 1B40, 10 Center Drive, Bethesda, MD 20892-1088, USA, martinwb@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 5176 EP - 5181 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 14 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Fluorescence KW - Monoclonal antibodies KW - Microscopy KW - Probes KW - Positron emission tomography KW - Radioisotopes KW - Fluorescent indicators KW - imaging KW - Cancer KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20154894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Toward+preparation+of+antibody-based+imaging+probe+libraries+for+dual-modality+positron+emission+tomography+and+fluorescence+imaging&rft.au=Xu%2C+Heng%3BEck%2C+Peter+K%3BBaidoo%2C+Kwamena+E%3BChoyke%2C+Peter+L%3BBrechbiel%2C+Martin+W&rft.aulast=Xu&rft.aufirst=Heng&rft.date=2009-07-01&rft.volume=17&rft.issue=14&rft.spage=5176&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2009.05.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Fluorescence; Monoclonal antibodies; Microscopy; Radioisotopes; Positron emission tomography; Probes; Fluorescent indicators; imaging; Cancer DO - http://dx.doi.org/10.1016/j.bmc.2009.05.048 ER - TY - JOUR T1 - Molecular recognition in the P2Y sub(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose AN - 20153311; 10278271 AB - The P2Y sub(14) receptor, a nucleotide signaling protein, is activated by uridine-5'-diphosphoglucose 1 and other uracil nucleotides. We have determined that the glucose moiety of 1 is the most structurally permissive region for designing analogues of this P2Y sub(14) agonist. For example, the carboxylate group of uridine-5'-diphosphoglucuronic acid proved to be suitable for flexible substitution by chain extension through an amide linkage. Functionalized congeners containing terminal 2-acylaminoethylamides prepared by this strategy retained P2Y sub(14) activity, and molecular modeling predicted close proximity of this chain to the second extracellular loop of the receptor. In addition, replacement of glucose with other sugars did not diminish P2Y sub(14) potency. For example, the [5'']ribose derivative had an EC sub(50) of 0.24 mu M. Selective monofluorination of the glucose moiety indicated a role for the 2''- and 6''-hydroxyl groups of 1 in receptor recognition. The beta -glucoside was twofold less potent than the native alpha -isomer, but methylene replacement of the 1''-oxygen abolished activity. Replacement of the ribose ring system with cyclopentyl or rigid bicyclo[3.1.0]hexane groups abolished activity. Uridine-5'-diphosphoglucose also activates the P2Y sub(2) receptor, but the 2-thio analogue and several of the potent modified-glucose analogues were P2Y sub(14)-selective. JF - Bioorganic and Medicinal Chemistry AU - Ko, Hyojin AU - Das, Arijit AU - Carter, Rhonda L AU - Fricks, Ingrid P AU - Zhou, Yixing AU - Ivanov, Andrei A AU - Melman, Artem AU - Joshi, Bhalchandra V AU - Kovac, Pavol AU - Hajduch, Jan AU - Kirk, Kenneth L AU - Harden, TKendall AU - Jacobson, Kenneth A AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, Bethesda, MD 20892, USA, kajacobs@helix.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 5298 EP - 5311 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 14 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Sugar KW - Molecular modelling KW - Uracil KW - Purine P2Y receptors KW - Ribose KW - Glucose KW - Congeners KW - amides KW - Nucleotides KW - Signal transduction KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20153311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Molecular+recognition+in+the+P2Y+sub%2814%29+receptor%3A+Probing+the+structurally+permissive+terminal+sugar+moiety+of+uridine-5%27-diphosphoglucose&rft.au=Ko%2C+Hyojin%3BDas%2C+Arijit%3BCarter%2C+Rhonda+L%3BFricks%2C+Ingrid+P%3BZhou%2C+Yixing%3BIvanov%2C+Andrei+A%3BMelman%2C+Artem%3BJoshi%2C+Bhalchandra+V%3BKovac%2C+Pavol%3BHajduch%2C+Jan%3BKirk%2C+Kenneth+L%3BHarden%2C+TKendall%3BJacobson%2C+Kenneth+A&rft.aulast=Ko&rft.aufirst=Hyojin&rft.date=2009-07-01&rft.volume=17&rft.issue=14&rft.spage=5298&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2009.05.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Sugar; Uracil; Ribose; Purine P2Y receptors; Glucose; Congeners; amides; Nucleotides; Signal transduction DO - http://dx.doi.org/10.1016/j.bmc.2009.05.024 ER - TY - JOUR T1 - Predictive models of toxicity with external radiotherapy for prostate cancer AN - 20147707; 10259871 AB - The objective of the current study was to analyze the state of the art and present limitations of available predictive clinical models (when available) estimating the risk of genitourinary tract and small bowel complications, erectile dysfunction, and acute and late symptoms of the rectal syndrome caused by prostate cancer external irradiation. An analysis of the literature indicated that very limited attention has been devoted to the development of integrated, patient-tailored, user-friendly, and clinically usable tools for the prediction of external beam radiotoxicity. In this article, the authors reported on the multivariate correlation between late genitourinary and gastrointestinal toxicities and clinical/dosimetric risk factors, as well as on the first set of nomograms developed to predict acute and late rectal side effects. At the present state of knowledge, the use of nomograms as predictive instruments of radiotoxicity appears to be particularly attractive for several main reasons. They are user friendly and easily developed using the results of multivariate analyses, as they weigh the combined effects of multiple independent factors found to be correlated with the selected clinical endpoint. The integrated evaluation of clinical and dosimetric parameters in the single patient can help to provide a tailored probability of the specific outcome considered. Predicting a high probability of toxicity could avoid unnecessary daily costs for the individual patient in terms of quality of life modification during and after treatment, helping patients in the decision-making process of choosing the best individual, quality of life-related treatment, and clinicians in better tailoring the treatment to patient's characteristics. Cancer 2009; 115(13 suppl):3141-9. JF - Cancer AU - Valdagni, Riccardo AU - Rancati, Tiziana AU - Fiorino, Claudio AD - Prostate Program, Scientific Directorate, National Cancer Institute, Milan, Italy, riccardo.valdagni@istitutotumori.mi.it Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 3141 EP - 3149 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA, [mailto:info@wiley.com], [URL:http://www.wiley.com/WileyCDA/Brand/id-35.html] VL - 115 SN - 0008-543X, 0008-543X KW - Toxicology Abstracts KW - Rectum KW - Radiotherapy KW - Genitourinary tract KW - Toxicity KW - Models KW - Decision making KW - Prostate cancer KW - Radiation KW - Multivariate analysis KW - Risk factors KW - Intestine KW - Side effects KW - Quality of life KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20147707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Predictive+models+of+toxicity+with+external+radiotherapy+for+prostate+cancer&rft.au=Valdagni%2C+Riccardo%3BRancati%2C+Tiziana%3BFiorino%2C+Claudio&rft.aulast=Valdagni&rft.aufirst=Riccardo&rft.date=2009-07-01&rft.volume=115&rft.issue=&rft.spage=3141&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Rectum; Radiotherapy; Genitourinary tract; Toxicity; Models; Decision making; Prostate cancer; Radiation; Multivariate analysis; Risk factors; Intestine; Side effects; Quality of life DO - http://dx.doi.org/10.1002/cncr.24356 ER - TY - JOUR T1 - Value of Adding Single-Nucleotide Polymorphism Genotypes to a Breast Cancer Risk Model AN - 20115825; 10209693 AB - Background Adding genotypes from seven single-nucleotide polymorphisms (SNPs), which had previously been associated with breast cancer, to the National Cancer Institute's Breast Cancer Risk Assessment Tool (BCRAT) increases the area under the receiver operating characteristic curve from 0.607 to 0.632.Methods Criteria that are based on four clinical or public health applications were used to compare BCRAT with BCRATplus7, which includes the seven genotypes. Criteria included number of expected life-threatening events for the decision to take tamoxifen, expected decision losses (in units of the loss from giving a mammogram to a woman without detectable breast cancer) for the decision to have a mammogram, rates of risk reclassification, and number of lives saved by risk-based allocation of screening mammography. For all calculations, the following assumptions were made: Hardy-Weinberg equilibrium, linkage equilibrium across SNPs, additive effects of alleles at each locus, no interactions on the logistic scale among SNPs or with factors in BCRAT, and independence of SNPs from factors in BCRAT.Results Improvements in expected numbers of life-threatening events were only 0.07% and 0.81% for deciding whether to take tamoxifen to prevent breast cancer for women aged 50-59 and 40-49 years, respectively. For deciding whether to recommend screening mammograms to women aged 50-54 years, the reduction in expected losses was 0.86% if the ideal breast cancer prevalence threshold for recommending mammography was that of women aged 50-54 years. Cross-classification of risks indicated that some women classified by BCRAT would have different classifications with BCRATplus7, which might be useful if BCRATplus7 was well calibrated. Improvements from BCRATplus7 were small for risk-based allocation of mammograms under costs constraints.Conclusions The gains from BCRATplus7 are small in the applications examined. Models with SNPs, such as BCRATplus7, have not been validated for calibration in independent cohort data. Additional studies are needed to validate a model with SNPs and justify its use. JF - Journal of the National Cancer Institute AU - Gail, Mitchell H Y1 - 2009/07/01/ PY - 2009 DA - 2009 Jul 01 SP - 959 EP - 963 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 101 IS - 13 SN - 0027-8874, 0027-8874 KW - Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts KW - Risk assessment KW - Reclassification KW - Mammography KW - Data processing KW - Genotypes KW - Tamoxifen KW - Cancer KW - Models KW - Public health KW - Classification KW - Single-nucleotide polymorphism KW - classification KW - Breast cancer KW - R2 23060:Medical and environmental health KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20115825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Value+of+Adding+Single-Nucleotide+Polymorphism+Genotypes+to+a+Breast+Cancer+Risk+Model&rft.au=Gail%2C+Mitchell+H&rft.aulast=Gail&rft.aufirst=Mitchell&rft.date=2009-07-01&rft.volume=101&rft.issue=13&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp130 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Reclassification; Data processing; Mammography; Classification; Single-nucleotide polymorphism; Breast cancer; Tamoxifen; Public health; Models; classification; Genotypes; Cancer DO - http://dx.doi.org/10.1093/jnci/djp130 ER - TY - JOUR T1 - Remarks on q-space MR propagator in partially restricted, axially-symmetric, and isotropic environments AN - 20080968; 10185666 AB - The problem of reconstruction of an apparent propagator from a series of diffusion-attenuated magnetic resonance (MR) signals is revisited. In nonimaging acquisitions, the inverse Fourier transform of the MR signal attenuation is consistent with the notion of an ensemble average propagator. However, in image acquisitions where one is interested in quantifying a displacement distribution in every voxel of the image, the propagator derived in the traditional way may lead to a counter-intuitive profile when it is nonsymmetric, which could be a problem in partially restricted environments. By exploiting the reciprocity of the diffusion propagator, an alternative is introduced, which implies a forward Fourier transform of the MR signal attenuations yielding a propagator reflected around the origin. Two simple problems were considered as examples. In the case of diffusion in the proximity of a restricting barrier, the reflected propagator yields a more meaningful result, whereas in the case of curving fibers, the original propagator is more intuitive. In the final section of the article, two more one-dimensional transformations are introduced, which enable the reconstruction of two- and three-dimensional propagators in, respectively, axially symmetric and isotropic environments - in both cases, from one-dimensional q-space MR data. JF - Magnetic Resonance Imaging AU - Oezarslan, Evren AU - Koay, Cheng Guan AU - Basser, Peter J AD - Section on Tissue Biophysics and Biomimetics, LIMB, NICHD, National Institutes of Health, Bethesda, MD 20892, USA, evren@helix.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 834 EP - 844 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 27 IS - 6 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts KW - Transformation KW - Fibers KW - Data processing KW - Magnetic resonance imaging KW - N.M.R. KW - Diffusion KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20080968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Remarks+on+q-space+MR+propagator+in+partially+restricted%2C+axially-symmetric%2C+and+isotropic+environments&rft.au=Oezarslan%2C+Evren%3BKoay%2C+Cheng+Guan%3BBasser%2C+Peter+J&rft.aulast=Oezarslan&rft.aufirst=Evren&rft.date=2009-07-01&rft.volume=27&rft.issue=6&rft.spage=834&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2009.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diffusion; N.M.R.; Magnetic resonance imaging; Data processing; Fibers; Transformation DO - http://dx.doi.org/10.1016/j.mri.2009.01.005 ER - TY - JOUR T1 - In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is mediated by Hoxa9 AN - 20077073; 10098791 AB - Inactivating mutations in the tumor suppressor gene MEN1 cause the inherited cancer syndrome multiple endocrine neoplasia type 1 (MEN1). The ubiquitously expressed MEN1 encoded protein, menin, interacts with MLL (mixed-lineage leukemia protein), and together they are essential components of a multiprotein complex with histone methyl transferase activity. MLL is also essential for hematopoiesis, and plays a critical role in leukemogenesis via epigenetic regulation of Hoxa9 expression that also requires menin. Therefore we chose to explore the role of menin in hematopoiesis. We generated Men1[super]-/- embryonic stem (ES) cell lines, and induced them to differentiate in vitro. While these cells were able to form embryoid bodies (EBs) expressing the early markers Flk-1 and c-Kit, their ability to further differentiate into hematopoietic colonies was compromised. The Men1[super]-/- ES cells show reduced expression of Hoxa9 that can be recovered by reexpression of Menin. We demonstrate that the block in differentiation of Men1[super]-/- ES cell lines can be rescued not only by the expression of menin but also that of Hoxa9. These results suggest that, similar to MLL, menin is required for hematopoiesis, and this requirement may be mediated through regulation of Hoxa9 expression. JF - Mechanisms of Development AU - Novotny, Elizabeth AU - Compton, Sheila AU - Liu, PPaul AU - Collins, Francis S AU - Chandrasekharappa, Settara C AD - Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA, chandra@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 517 EP - 522 PB - Elsevier Science VL - 126 IS - 7 SN - 0925-4773, 0925-4773 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Oncogenes & Growth Factors Abstracts KW - Embryonic stem cells KW - ES KW - Hematopoiesis KW - Mixed-lineage leukemia KW - Multiple endocrine neoplasia type 1 KW - Menin KW - Hoxa9. KW - c-Kit protein KW - Tumor suppressor genes KW - Histones KW - multiple endocrine neoplasia KW - Leukemogenesis KW - MEN1 protein KW - Cancer KW - Differentiation KW - Colonies KW - Stem cells KW - Embryo cells KW - epigenetics KW - MLL protein KW - Hemopoiesis KW - Vascular endothelial growth factor receptor 2 KW - Mutation KW - B 26600:Tyrosine Kinase Activity KW - W 30940:Products KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20077073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+Development&rft.atitle=In+vitro+hematopoietic+differentiation+of+mouse+embryonic+stem+cells+requires+the+tumor+suppressor+menin+and+is+mediated+by+Hoxa9&rft.au=Novotny%2C+Elizabeth%3BCompton%2C+Sheila%3BLiu%2C+PPaul%3BCollins%2C+Francis+S%3BChandrasekharappa%2C+Settara+C&rft.aulast=Novotny&rft.aufirst=Elizabeth&rft.date=2009-07-01&rft.volume=126&rft.issue=7&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+Development&rft.issn=09254773&rft_id=info:doi/10.1016%2Fj.mod.2009.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; c-Kit protein; Histones; multiple endocrine neoplasia; MEN1 protein; Leukemogenesis; Cancer; Differentiation; Stem cells; Colonies; Embryo cells; MLL protein; epigenetics; Hemopoiesis; Vascular endothelial growth factor receptor 2; Mutation DO - http://dx.doi.org/10.1016/j.mod.2009.04.001 ER - TY - JOUR T1 - Stem cells in melanoma development AN - 20066887; 10067897 AB - Cutaneous melanoma is a significant health problem worldwide. Available treatments can induce objective tumor regression in a small percent of patients, but these responses are not always associated with improved long-term survival. The resistance of melanoma to therapy and its predestined recurrence are related to the genetic heterogeneity and genomic instability of the tumor. For many years these genetic alterations were thought to be linked to the accumulation of random mutations in functionally differentiated cells which transform them into malignant cells that have lost their ability to differentiate and have acquired drug resistance. In the last few years it has been largely demonstrated that melanoma as other solid tumors contains a subpopulation of cells (CSCs) considered the source of the primary tumor mass, of new tumor nodules and responsible for drug resistance and cancer recurrence. In this review, we provide an overview of findings and advances in CSCs research that are relevant to the initiation, natural history, and the response to treatment of malignant melanoma. JF - Cancer Letters AU - Sabatino, Marianna AU - Stroncek, David F AU - Klein, Harvey AU - Marincola, Francesco M AU - Wang, Ena AD - Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, 9000 Rockville Pike, Building 10 Room 1C711, Bethesda, MD 20892, United States, ewang@mail.cc.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 119 EP - 125 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 279 IS - 2 SN - 0304-3835, 0304-3835 KW - Biotechnology and Bioengineering Abstracts KW - Melanoma stem cells KW - Cancer stem cells KW - Stem cells KW - Genomic instability KW - Solid tumors KW - Drug resistance KW - Reviews KW - Tumors KW - Development KW - Mutation KW - Nodules KW - Cancer KW - Melanoma KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20066887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=Stem+cells+in+melanoma+development&rft.au=Sabatino%2C+Marianna%3BStroncek%2C+David+F%3BKlein%2C+Harvey%3BMarincola%2C+Francesco+M%3BWang%2C+Ena&rft.aulast=Sabatino&rft.aufirst=Marianna&rft.date=2009-07-01&rft.volume=279&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/10.1016%2Fj.canlet.2008.10.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Stem cells; Genomic instability; Solid tumors; Reviews; Drug resistance; Development; Tumors; Mutation; Cancer; Nodules; Melanoma DO - http://dx.doi.org/10.1016/j.canlet.2008.10.039 ER - TY - JOUR T1 - Transgenic mice expressing a cameleon fluorescent Ca super(2+) indicator in astrocytes and Schwann cells allow study of glial cell Ca super(2+) signals in situ and in vivo AN - 20061457; 10235990 AB - Glial cell Ca super(2+) signals play a key role in glial-neuronal and glial-glial network communication. Numerous studies have thus far utilized cell-permeant and injected Ca super(2+) indicator dyes to investigate glial Ca super(2+) signals in vitro and in situ. Genetically encoded fluorescent Ca super(2+) indicators have emerged as novel probes for investigating cellular Ca super(2+) signals. We have expressed one such indicator protein, the YC 3.60 cameleon, under the control of the S100 beta promoter and directed its expression predominantly in astrocytes and Schwann cells. Expression of YC 3.60 extended into the entire cellular cytoplasmic compartment and the fine terminal processes of protoplasmic astrocytes and Schwann cell Cajal bands. In the brain, all the cells known to express S100 beta in the adult or during development, expressed YC 3.60. While expression was most extensive in astrocytes, other glial cell types that express S100 beta , such as NG2 and CNP-positive oligodendrocyte progenitor cells (OP cells), microglia, and some of the large motor neurons in the brain stem, also contained YC 3.60 fluorescence. Using a variety of known in situ and in vivo assays, we found that stimuli known to elicit Ca super(2+) signals in astrocytes caused substantial and rapid Ca super(2+) signals in the YC 3.60-expressing astrocytes. In addition, forepaw stimulation while imaging astrocytes through a cranial window in the somatosensory cortex in live mice, revealed robust evoked and spontaneous Ca super(2+) signals. These results, for the first time, show that genetically encoded reporter is capable of recording activity-dependent Ca super(2+) signals in the astrocyte processes, and networks. JF - Journal of Neuroscience Methods AU - Atkin, Stan D AU - Patel, Sundip AU - Kocharyan, Ara AU - Holtzclaw, Lynne A AU - Weerth, Susanna H AU - Schram, Vincent AU - Pickel, James AU - Russell, James T AD - Section on Cell Biology and Signal Transduction, NICHD, NIH, Bethesda, MD, United States, james@helix.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 212 EP - 226 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 181 IS - 2 SN - 0165-0270, 0165-0270 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts; CSA Neurosciences Abstracts KW - YC 3.60 cameleon KW - Astrocytes KW - Schwann cells KW - Transgenic mice KW - Neuroimaging KW - Fluorescence KW - S100 beta protein KW - Glial cells KW - Brain stem KW - Calcium imaging KW - Development KW - Microglia KW - Motor neurons KW - Promoters KW - Nervous system KW - Glial stem cells KW - Skull KW - Dyes KW - Computed tomography KW - Fluorescent indicators KW - Calcium signalling KW - Cell interactions KW - Cortex (somatosensory) KW - W 30910:Imaging KW - T 2000:Cellular Calcium KW - N3 11003:Developmental neuroscience KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20061457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience+Methods&rft.atitle=Transgenic+mice+expressing+a+cameleon+fluorescent+Ca+super%282%2B%29+indicator+in+astrocytes+and+Schwann+cells+allow+study+of+glial+cell+Ca+super%282%2B%29+signals+in+situ+and+in+vivo&rft.au=Atkin%2C+Stan+D%3BPatel%2C+Sundip%3BKocharyan%2C+Ara%3BHoltzclaw%2C+Lynne+A%3BWeerth%2C+Susanna+H%3BSchram%2C+Vincent%3BPickel%2C+James%3BRussell%2C+James+T&rft.aulast=Atkin&rft.aufirst=Stan&rft.date=2009-07-01&rft.volume=181&rft.issue=2&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience+Methods&rft.issn=01650270&rft_id=info:doi/10.1016%2Fj.jneumeth.2009.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Neuroimaging; S100 beta protein; Fluorescence; Astrocytes; Glial cells; Brain stem; Schwann cells; Calcium imaging; Development; Microglia; Transgenic mice; Promoters; Motor neurons; Nervous system; Glial stem cells; Dyes; Skull; Computed tomography; Fluorescent indicators; Calcium signalling; Cell interactions; Cortex (somatosensory) DO - http://dx.doi.org/10.1016/j.jneumeth.2009.05.006 ER - TY - JOUR T1 - Validation of the Functional Status II questionnaire in the assessment of extremely-low-birthweight infants AN - 195608593; 19459909 AB - The increased survival of infants born at extremely low birthweight (ELBW) has been associated with significant morbidity, including higher rates of neurodevelopmental disability. However, formalized testing to evaluate these problems is both time-consuming and costly. The revised Functional Status questionnaire (FS-II) was designed to assess caregivers' perceptions of the functional status of children with chronic diseases. We evaluated the reliability and validity of the FS-II for ELBWinfants at 18 to 22 months corrected age using data from the US Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network (NRN). Exploratory factor analyses were conducted using data from the network's first follow-up study of 1080 children born in 1993 to 1994 (508 males, 572 females [53%]), and results were confirmed using data from the next network follow-up of 4022 children born in 1995 to 2000 (1864 males, 2158 females [54%]). Results suggest that a two-factor solution comprising measures of general health and independence is most appropriate for ELBW infants. These factors differed from those found among chronically ill children, and new, more appropriate scales are presented for screening ELBWsurvivors. Both scales demonstrated good internal consistency: Cronbach's a=0.87 for general health and a=0.75 for independence. Construct validity of the scales was assessed by comparing mean scores on the scales according to scores on the Bayley Scales of Infant Development, second edition (BSID-II), and medical conditions. As hypothesized, infants with greater functional impairments according to their BSID-II scores or medical conditions had lower scores on the general health and independence scales, supporting the validity of the scales. JF - Developmental Medicine and Child Neurology AU - Da Costa, David, MD AU - Bann, Carla M, PHD AU - Hansen, Nellie I, MPH AU - Shankaran, Seetha, MD AU - Delaney-Black, Virginia, MD MPH Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 536 EP - 44 CY - London PB - Mac Keith Press VL - 51 IS - 7 SN - 00121622 KW - Children And Youth - About KW - Severity of Illness Index KW - Questionnaires KW - Reproducibility of Results KW - Humans KW - Infant, Newborn KW - Activities of Daily Living KW - Psychometrics KW - Infant KW - Factor Analysis, Statistical KW - Child Development KW - Follow-Up Studies KW - Sensitivity & Specificity KW - Statistics, Nonparametric KW - Female KW - Male KW - Health Status Indicators KW - Developmental Disabilities -- diagnosis KW - Disability Evaluation KW - Quality of Life KW - Infant, Extremely Low Birth Weight UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/195608593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Medicine+and+Child+Neurology&rft.atitle=Validation+of+the+Functional+Status+II+questionnaire+in+the+assessment+of+extremely-low-birthweight+infants&rft.au=Da+Costa%2C+David%2C+MD%3BBann%2C+Carla+M%2C+PHD%3BHansen%2C+Nellie+I%2C+MPH%3BShankaran%2C+Seetha%2C+MD%3BDelaney-Black%2C+Virginia%2C+MD+MPH&rft.aulast=Da+Costa&rft.aufirst=David&rft.date=2009-07-01&rft.volume=51&rft.issue=7&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Developmental+Medicine+and+Child+Neurology&rft.issn=00121622&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Mac Keith Press Jul 2009 N1 - Last updated - 2012-02-22 N1 - CODEN - DMCNAW ER - TY - JOUR T1 - Human mesenchymal stem cells express vascular cell phenotypes upon interaction with endothelial cell matrix AN - 1022564920; 15244284 AB - Mesenchymal stem cells (MSCs) are thought to occupy a perivascular niche where they are exposed to signals originating from vascular cells. This study focused on the effects of endothelial cell (EC)-derived signals on MSC differentiation toward vascular cell lineages. Upon co-culture with two types of ECs, macrovascular (macro) ECs and microvascular (micro) ECs, the former caused MSCs to increase expression of both EC and smooth muscle cell (SMC) markers, while the latter induced expression of EC markers only. These marker changes in MSCs were linked to the extracellular matrixes secreted by the ECs (EC-matrix) rather than soluble EC-secreted factors. Beyond enhanced marker expression, EC-matrix also induced functional changes in MSCs indicative of development of a genuine vascular cell phenotype. These included enhanced incorporation into vessels and cytoskeletal localization of vascular SMC-specific contractile elements. The bioactivity of EC-matrix was sensitive to EDTA washes and required sulfated glycosaminoglycans. However, neither soluble VEGF nor substrate surfaces coated with fibronectin, collagen type IV, or laminin recreated the effects of EC-matrix on MSC vascular differentiation. In conclusion, these results identified EC-matrix as a critical regulator of vascular cell differentiation of MSCs. Elucidating these MSC-EC-matrix interactions and identifying the specific EC-matrix components involved will shed light on the perivascular signals seen by MSCs in vivo. J. Cell. Biochem. 107: 714-722, 2009. Published 2009 Wiley-Liss, Inc. JF - Journal of Cellular Biochemistry AU - Lozito, Thomas P AU - Kuo, Catherine K AU - Taboas, Juan M AU - Tuan, Rocky S Y1 - 2009/07/01/ PY - 2009 DA - 2009 Jul 01 SP - 714 EP - 722 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 107 IS - 4 SN - 1097-4644, 1097-4644 KW - Biotechnology and Bioengineering Abstracts KW - Cell lineage KW - Collagen (type IV) KW - Cytoskeleton KW - Differentiation KW - Edetic acid KW - Endothelial cells KW - Fibronectin KW - Glycosaminoglycans KW - Laminin KW - Mesenchyme KW - Microvasculature KW - Muscle contraction KW - Smooth muscle KW - Stem cells KW - Vascular endothelial growth factor KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1022564920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cellular+Biochemistry&rft.atitle=Human+mesenchymal+stem+cells+express+vascular+cell+phenotypes+upon+interaction+with+endothelial+cell+matrix&rft.au=Lozito%2C+Thomas+P%3BKuo%2C+Catherine+K%3BTaboas%2C+Juan+M%3BTuan%2C+Rocky+S&rft.aulast=Lozito&rft.aufirst=Thomas&rft.date=2009-07-01&rft.volume=107&rft.issue=4&rft.spage=714&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cellular+Biochemistry&rft.issn=10974644&rft_id=info:doi/10.1002%2Fjcb.22167 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jcb.22167/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Cell lineage; Vascular endothelial growth factor; Smooth muscle; Laminin; Microvasculature; Collagen (type IV); Muscle contraction; Fibronectin; Endothelial cells; Cytoskeleton; Differentiation; Stem cells; Glycosaminoglycans; Mesenchyme; Edetic acid DO - http://dx.doi.org/10.1002/jcb.22167 ER - TY - JOUR T1 - Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatum. AN - 67437303; 19564919 AB - Methamphetamine (METH) is an illicit toxic psychostimulant which is widely abused. Its toxic effects depend on the release of excessive levels of dopamine (DA) that activates striatal DA receptors. Inhibition of DA-mediated neurotransmission by the DA D1 receptor antagonist, SCH23390, protects against METH-induced neuronal apoptosis. The initial purpose of the present study was to investigate, using microarray analyses, the influence of SCH23390 on transcriptional responses in the rat striatum caused by a single METH injection at 2 and 4 hours after drug administration. We identified 545 out of a total of 22,227 genes as METH-responsive. These include genes which are involved in apoptotic pathways, endoplasmic reticulum (ER) stress, and in transcription regulation, among others. Of these, a total of 172 genes showed SCH23390-induced inhibition of METH-mediated changes. Among these SCH23390-responsive genes were several genes that are regulated during ER stress, namely ATF3, HSP27, Hmox1, HSP40, and CHOP/Gadd153. The secondary goal of the study was to investigate the role of DA D1 receptor stimulation on the expression of genes that participate in ER stress-mediated molecular events. We thus used quantitative PCR to confirm changes in the METH-responsive ER genes identified by the microarray analyses. We also measured the expression of these genes and of ATF4, ATF6, BiP/GRP78, and of GADD34 over a more extended time course. SCH23390 attenuated or blocked METH-induced increases in the expression of the majority of these genes. Western blot analysis revealed METH-induced increases in the expression of the antioxidant protein, Hmox1, which lasted for about 24 hours after the METH injection. Additionally, METH caused DA D1 receptor-dependent transit of the Hmox1 regulator protein, Nrf2, from cytosolic into nuclear fractions where the protein exerts its regulatory functions. When taken together, these findings indicate that SCH23390 can provide protection against neuronal apoptosis by inhibiting METH-mediated DA D1 receptor-mediated ER stress in the rat striatum. Our data also suggest that METH-induced toxicity might be a useful model to dissect molecular mechanisms involved in ER stress-dependent events in the rodent brain. JF - PloS one AU - Jayanthi, Subramaniam AU - McCoy, Michael T AU - Beauvais, Genevieve AU - Ladenheim, Bruce AU - Gilmore, Kristi AU - Wood, William AU - Becker, Kevin AU - Cadet, Jean Lud AD - Molecular Neuropsychiatry Research Branch, National Institute of Drug Abuse, National Institutes of Health (NIH)/Department of Health and Human Services (DHHS), Intramural Research Program, Baltimore, MD, USA. Y1 - 2009/06/30/ PY - 2009 DA - 2009 Jun 30 SP - 1 VL - 4 IS - 6 KW - Benzazepines KW - 0 KW - Dopamine Agents KW - Receptors, Dopamine D1 KW - SCH 23390 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Benzazepines -- pharmacology KW - Apoptosis KW - Oligonucleotide Array Sequence Analysis KW - Synaptic Transmission -- drug effects KW - Dopamine Agents -- pharmacology KW - Models, Biological KW - Male KW - Neurons -- pathology KW - Methamphetamine -- pharmacology KW - Corpus Striatum -- drug effects KW - Receptors, Dopamine D1 -- metabolism KW - Endoplasmic Reticulum -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67437303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Methamphetamine+induces+dopamine+D1+receptor-dependent+endoplasmic+reticulum+stress-related+molecular+events+in+the+rat+striatum.&rft.au=Jayanthi%2C+Subramaniam%3BMcCoy%2C+Michael+T%3BBeauvais%2C+Genevieve%3BLadenheim%2C+Bruce%3BGilmore%2C+Kristi%3BWood%2C+William%3BBecker%2C+Kevin%3BCadet%2C+Jean+Lud&rft.aulast=Jayanthi&rft.aufirst=Subramaniam&rft.date=2009-06-30&rft.volume=4&rft.issue=6&rft.spage=e6092&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0006092 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-06-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2007 Aug 24;282(34):25088-99 [17597071] Mol Biol Cell. 2007 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Med. 2008 Oct;74(13):1526-39 [18937164] Nat Rev Drug Discov. 2008 Dec;7(12):1013-30 [19043451] Cancer Lett. 2009 Feb 8;274(1):40-6 [18829155] J Invest Surg. 2009 Jan-Feb;22(1):29-34 [19191155] FASEB J. 1999 Nov;13(14):2061-70 [10544189] Mol Biol Cell. 1999 Nov;10(11):3787-99 [10564271] Brain Res Dev Brain Res. 2000 Jan 3;119(1):139-53 [10648880] Brain Res. 2000 Apr 28;863(1-2):106-11 [10773198] Nat Cell Biol. 2000 Jun;2(6):326-32 [10854322] Mol Cell. 2000 May;5(5):897-904 [10882126] Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10242-7 [10963684] Free Radic Biol Med. 2000 Aug;29(3-4):254-62 [11035254] J Biochem. 2000 Sep;128(3):399-405 [10965038] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0006092 ER - TY - JOUR T1 - A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats AN - 20614224; 9334279 AB - Psychostimulant addicts often take high doses of drugs, and high doses of psychostimulants such as methamphetamine (METH) are neurotoxic to striatal dopamine (DA) terminals. Yet, the effects of high doses of METH on drug-seeking and drug-taking behavior have not been examined. In the present study, we found that single high doses of METH in rats (10-20 mg/kg) dose-dependently increased cocaine self-administration under fixed-ratio 2 (FR2) reinforcement conditions, while higher doses (40 mg/kgx1 or 10 mg/kg/2 hx4) caused high mortality among rats maintained on daily cocaine self-administration. The increased cocaine self-administration appeared to be a compensatory response to reduced cocaine reward after METH, because the same doses of METH caused a dose-dependent reduction both in ''break-point'' levels for cocaine self-administration under progressive-ratio reinforcement and in nucleus accumbens DA response to acute cocaine. Further, METH (10-20 mg/kg) produced large DA release (4000%-6000% over baseline), followed by a significant reduction in striatal DA and 3,4-dihydroxyphenylacetic acid (DOPAC) contents, but without significant changes in striatal DA transporter levels. These findings suggest that the present high doses of METH caused striatal DA depletion or hypofunction without severe damage in DA terminals, which may contribute to the increased cocaine-taking behavior observed in the present study. Provided that the present doses of METH may mimic METH overdose incidents in humans, the present findings suggest that METH-induced DA depletion or neurotoxicity may lead to an increase in subsequent drug-taking and drug-seeking behavior. JF - Neuroscience AU - Xi, Z X AU - Kleitz, H K AU - Deng, X AU - Ladenheim, B AU - Peng, X Q AU - Li, X AU - Gardner, EL AU - Stein, E A AU - Cadet, J L AD - Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Boulevard, BRC Room 05A705, Baltimore, MD 21224, USA, zxi@intra.nida.nih.gov Y1 - 2009/06/30/ PY - 2009 DA - 2009 Jun 30 SP - 392 EP - 402 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 161 IS - 2 SN - 0306-4522, 0306-4522 KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - Nucleus accumbens KW - Mortality KW - Addicts KW - Drug abuse KW - Nervous system KW - Methamphetamine KW - Overdose KW - Dopamine transporter KW - Dopamine KW - Neurotoxicity KW - Neostriatum KW - Reinforcement KW - Drug addiction KW - Cocaine KW - Drug self-administration KW - X 24380:Social Poisons & Drug Abuse KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20614224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=A+single+high+dose+of+methamphetamine+increases+cocaine+self-administration+by+depletion+of+striatal+dopamine+in+rats&rft.au=Xi%2C+Z+X%3BKleitz%2C+H+K%3BDeng%2C+X%3BLadenheim%2C+B%3BPeng%2C+X+Q%3BLi%2C+X%3BGardner%2C+EL%3BStein%2C+E+A%3BCadet%2C+J+L&rft.aulast=Xi&rft.aufirst=Z&rft.date=2009-06-30&rft.volume=161&rft.issue=2&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2009.03.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Nucleus accumbens; Addicts; Drug abuse; Dopamine transporter; Overdose; Methamphetamine; Nervous system; Dopamine; Neostriatum; Neurotoxicity; Reinforcement; Cocaine; Drug addiction; Drug self-administration DO - http://dx.doi.org/10.1016/j.neuroscience.2009.03.060 ER - TY - CPAPER T1 - FPN1B, a novel ferroportin transcript lacking an iron responsive element, enables duodenal and erythroid precursor cells to evade translational repression T2 - 2009 Gordon Research Conference on Red Cells AN - 40306659; 5241884 JF - 2009 Gordon Research Conference on Red Cells AU - Zhang, Deliang Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - Iron KW - Translation KW - Regulatory sequences KW - Transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40306659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Red+Cells&rft.atitle=FPN1B%2C+a+novel+ferroportin+transcript+lacking+an+iron+responsive+element%2C+enables+duodenal+and+erythroid+precursor+cells+to+evade+translational+repression&rft.au=Zhang%2C+Deliang&rft.aulast=Zhang&rft.aufirst=Deliang&rft.date=2009-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Red+Cells&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=redcells LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structures and Detection of Prion Protein Isoforms T2 - Amyloid Fibril Formation and Protein Misfolding: Molecular Mechanisms and Cellular Effects AN - 40301356; 5240050 JF - Amyloid Fibril Formation and Protein Misfolding: Molecular Mechanisms and Cellular Effects AU - Caughey, Byron Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - Prion protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40301356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Amyloid+Fibril+Formation+and+Protein+Misfolding%3A+Molecular+Mechanisms+and+Cellular+Effects&rft.atitle=Structures+and+Detection+of+Prion+Protein+Isoforms&rft.au=Caughey%2C+Byron&rft.aulast=Caughey&rft.aufirst=Byron&rft.date=2009-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Amyloid+Fibril+Formation+and+Protein+Misfolding%3A+Molecular+Mechanisms+and+Cellular+Effects&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11703.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sphingosine-1-phosphate metabolism and its role in physiology T2 - Lysophospholipid Mediators in Health and Disease AN - 40294877; 5239938 JF - Lysophospholipid Mediators in Health and Disease AU - Proia, Richard Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - Metabolism KW - Physiology KW - Sphingosine 1-phosphate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40294877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Lysophospholipid+Mediators+in+Health+and+Disease&rft.atitle=Sphingosine-1-phosphate+metabolism+and+its+role+in+physiology&rft.au=Proia%2C+Richard&rft.aulast=Proia&rft.aufirst=Richard&rft.date=2009-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Lysophospholipid+Mediators+in+Health+and+Disease&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11653.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cooperation of sphingosine kinases, sphingosine- 1-phosphate, and the sphingosine-1-phosphate receptor 2 in determining anaphylactic susceptibility and recovery T2 - Lysophospholipid Mediators in Health and Disease AN - 40290765; 5239970 JF - Lysophospholipid Mediators in Health and Disease AU - Olivera, Ana Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - Sphingosine 1-phosphate KW - Anaphylaxis KW - Sphingosine kinase KW - Cooperation KW - Cooperativity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40290765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Lysophospholipid+Mediators+in+Health+and+Disease&rft.atitle=Cooperation+of+sphingosine+kinases%2C+sphingosine-+1-phosphate%2C+and+the+sphingosine-1-phosphate+receptor+2+in+determining+anaphylactic+susceptibility+and+recovery&rft.au=Olivera%2C+Ana&rft.aulast=Olivera&rft.aufirst=Ana&rft.date=2009-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Lysophospholipid+Mediators+in+Health+and+Disease&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11653.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Incidence and Correlates of Asymptomatic Chlamydia and Gonorrhea T2 - 18th Conference of the International Society for Sexually Transmitted Diseases Research (2009 ISSTDR/BASHH) AN - 40257622; 5226042 JF - 18th Conference of the International Society for Sexually Transmitted Diseases Research (2009 ISSTDR/BASHH) AU - Detels, R Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - Sexually-transmitted diseases KW - Gonorrhea KW - Chlamydia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40257622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Conference+of+the+International+Society+for+Sexually+Transmitted+Diseases+Research+%282009+ISSTDR%2FBASHH%29&rft.atitle=Incidence+and+Correlates+of+Asymptomatic+Chlamydia+and+Gonorrhea&rft.au=Detels%2C+R&rft.aulast=Detels&rft.aufirst=R&rft.date=2009-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Conference+of+the+International+Society+for+Sexually+Transmitted+Diseases+Research+%282009+ISSTDR%2FBASHH%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congrexnetwork.com/dbs/ISSTDR/files/symp_sci_prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular architecture of retrovirus capsids: pentamers and hexamers of the two-domain CA protein T2 - 2009 Gordon Research Conference on Three Dimensional Electron Microscopy AN - 40200975; 5184524 JF - 2009 Gordon Research Conference on Three Dimensional Electron Microscopy AU - Cardone, Giovanni Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - Hexamers KW - Retrovirus KW - Capsids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40200975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Three+Dimensional+Electron+Microscopy&rft.atitle=Molecular+architecture+of+retrovirus+capsids%3A+pentamers+and+hexamers+of+the+two-domain+CA+protein&rft.au=Cardone%2C+Giovanni&rft.aulast=Cardone&rft.aufirst=Giovanni&rft.date=2009-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Three+Dimensional+Electron+Microscopy&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=threedim LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The structure of Dnm1, the yeast dynamin involved in mitochondria fission, using single particle helical methods T2 - 2009 Gordon Research Conference on Three Dimensional Electron Microscopy AN - 40198379; 5184519 JF - 2009 Gordon Research Conference on Three Dimensional Electron Microscopy AU - Mears, Jason Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - Particulates KW - Mitochondria KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40198379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Three+Dimensional+Electron+Microscopy&rft.atitle=The+structure+of+Dnm1%2C+the+yeast+dynamin+involved+in+mitochondria+fission%2C+using+single+particle+helical+methods&rft.au=Mears%2C+Jason&rft.aulast=Mears&rft.aufirst=Jason&rft.date=2009-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Three+Dimensional+Electron+Microscopy&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=threedim LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stress-responsive genes are poised for rapid, synchronous activation T2 - 2009 Gordon Research Conference on Stress Proteins in Growth, Development and Disease AN - 40185061; 5184262 JF - 2009 Gordon Research Conference on Stress Proteins in Growth, Development and Disease AU - Adelman, Karen Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40185061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Stress+Proteins+in+Growth%2C+Development+and+Disease&rft.atitle=Stress-responsive+genes+are+poised+for+rapid%2C+synchronous+activation&rft.au=Adelman%2C+Karen&rft.aulast=Adelman&rft.aufirst=Karen&rft.date=2009-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Stress+Proteins+in+Growth%2C+Development+and+Disease&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=stressprot LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii. AN - 67406295; 19380583 AB - Excitatory amino acid transporters (EAATs) are crucial in maintaining extracellular levels of glutamate, the most abundant excitatory neurotransmitter, below toxic levels. The recent three-dimensional crystal structure of GltPh, an archaeal homolog of the EAATs, provides elegant structural details of this family of proteins, yet we know little about the mechanism of the bacterial transporter. Conflicting reports in the literature have described GltPh as an aspartate transporter driven by Na+ or a glutamate transporter driven by either Na+ or H+. Here we use purified protein reconstituted into liposomes to thoroughly characterize the ion and substrate dependence of the GltPh transport. We confirm that GltPh is a Na+-dependent transporter that is highly selective for aspartate over other amino acids, and we show that transport is coupled to at least two Na+ ions. In contrast to the EAATs, transport via GltPh is independent of H+ and K+. We propose a kinetic model of transport in which at least two Na+ ions are coupled to the cotransport of each aspartate molecule by GltPh, and where an ion- and substrate-free transporter reorients to complete the transport cycle. JF - The Journal of biological chemistry AU - Ryan, Renae M AU - Compton, Emma L R AU - Mindell, Joseph A AD - Membrane Transport Biophysics Unit, Porter Neuroscience Center, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/06/26/ PY - 2009 DA - 2009 Jun 26 SP - 17540 EP - 17548 VL - 284 IS - 26 SN - 0021-9258, 0021-9258 KW - Amino Acid Transport Systems KW - 0 KW - Amino Acids KW - Excitatory Amino Acid Transporter 1 KW - Liposomes KW - Aspartic Acid KW - 30KYC7MIAI KW - Glutamic Acid KW - 3KX376GY7L KW - Hydrogen KW - 7YNJ3PO35Z KW - Sodium KW - 9NEZ333N27 KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Cells, Cultured KW - Kinetics KW - Biological Transport KW - Hydrogen -- metabolism KW - Amino Acids -- metabolism KW - Substrate Specificity KW - Potassium -- metabolism KW - Excitatory Amino Acid Transporter 1 -- metabolism KW - Aspartic Acid -- metabolism KW - Excitatory Amino Acid Transporter 1 -- isolation & purification KW - Amino Acid Transport Systems -- metabolism KW - Pyrococcus horikoshii -- metabolism KW - Excitatory Amino Acid Transporter 1 -- genetics KW - Sodium -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67406295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Functional+characterization+of+a+Na%2B-dependent+aspartate+transporter+from+Pyrococcus+horikoshii.&rft.au=Ryan%2C+Renae+M%3BCompton%2C+Emma+L+R%3BMindell%2C+Joseph+A&rft.aulast=Ryan&rft.aufirst=Renae&rft.date=2009-06-26&rft.volume=284&rft.issue=26&rft.spage=17540&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M109.005926 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-06 N1 - Date created - 2009-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2002 Aug 16;277(33):29847-55 [12015317] J Biol Chem. 2002 Jul 19;277(29):26074-80 [11994293] Nature. 2004 Feb 26;427(6977):803-7 [14985752] J Biol Chem. 2004 May 14;279(20):20742-51 [14982939] Nature. 2004 Oct 14;431(7010):811-8 [15483603] FEBS Lett. 1978 Oct 15;94(2):245-8 [700148] Biochemistry. 1978 Sep 19;17(19):3949-53 [708689] Biochemistry. 1990 Jul 17;29(28):6734-40 [1697765] Neuron. 1995 May;14(5):1019-27 [7748550] Nature. 1995 Jun 15;375(6532):599-603 [7791878] J Biol Chem. 1995 Jul 28;270(30):17668-71 [7629063] Neuron. 1995 Sep;15(3):721-8 [7546750] Biochim Biophys Acta. 1995 Oct 10;1231(3):223-46 [7578213] Biochemistry. 1996 May 14;35(19):6150-6 [8634258] J Neurosci. 1996 Nov 1;16(21):6722-31 [8824313] Nature. 1996 Oct 17;383(6601):634-7 [8857541] J Biol Chem. 1997 Jan 17;272(3):1703-8 [8999849] J Neurosci. 1998 Oct 1;18(19):7650-61 [9742136] Neuron. 1998 Sep;21(3):623-32 [9768848] Neuron. 1998 Dec;21(6):1487-98 [9883740] Microbiol Mol Biol Rev. 1999 Jun;63(2):293-307 [10357852] J Neurosci. 2005 Feb 16;25(7):1730-6 [15716409] Biochemistry. 2005 Sep 6;44(35):11913-23 [16128593] Biochemistry. 2006 Oct 24;45(42):12796-805 [17042498] Nature. 2007 Jan 25;445(7126):387-93 [17230192] Nat Struct Mol Biol. 2007 May;14(5):365-71 [17435767] Nature. 2008 Jun 5;453(7196):788-92 [18449189] Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14282-7 [10588697] J Biol Chem. 2000 Mar 31;275(13):9684-9 [10734120] J Biol Chem. 2000 Dec 1;275(48):37436-42 [10978338] J Biol Chem. 2001 Apr 6;276(14):10775-81 [11148213] Prog Neurobiol. 2001 Sep;65(1):1-105 [11369436] J Biol Chem. 2002 Apr 19;277(16):13494-500 [11815608] J Biol Chem. 2002 Apr 19;277(16):13501-7 [11823462] J Biol Chem. 2003 Jan 24;278(4):2585-92 [12419818] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.005926 ER - TY - CPAPER T1 - Openness vs. Secrecy in Scientific Research T2 - Sixth Annual Conference of the Episteme (A Journal of Social Epistemology) AN - 40200514; 5191817 JF - Sixth Annual Conference of the Episteme (A Journal of Social Epistemology) AU - Resnik, David Y1 - 2009/06/26/ PY - 2009 DA - 2009 Jun 26 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40200514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Conference+of+the+Episteme+%28A+Journal+of+Social+Epistemology%29&rft.atitle=Openness+vs.+Secrecy+in+Scientific+Research&rft.au=Resnik%2C+David&rft.aulast=Resnik&rft.aufirst=David&rft.date=2009-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Conference+of+the+Episteme+%28A+Journal+of+Social+Epistemology%29&rft.issn=&rft_id=info:doi/ L2 - http://epistemejournal.wordpress.com/conference/2009-northwestern/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Trouble with Being Normal: Informed Consent, Group Review, and Ways of Deciding at the National Institutes of Health T2 - 41st Annual Meeting of the Cheiron: International Society for the History of Behavioral and Social Sciences AN - 40243945; 5215182 JF - 41st Annual Meeting of the Cheiron: International Society for the History of Behavioral and Social Sciences AU - Stark, Laura Y1 - 2009/06/25/ PY - 2009 DA - 2009 Jun 25 KW - Reviews KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40243945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=41st+Annual+Meeting+of+the+Cheiron%3A+International+Society+for+the+History+of+Behavioral+and+Social+Sciences&rft.atitle=The+Trouble+with+Being+Normal%3A+Informed+Consent%2C+Group+Review%2C+and+Ways+of+Deciding+at+the+National+Institutes+of+Health&rft.au=Stark%2C+Laura&rft.aulast=Stark&rft.aufirst=Laura&rft.date=2009-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=41st+Annual+Meeting+of+the+Cheiron%3A+International+Society+for+the+History+of+Behavioral+and+Social+Sciences&rft.issn=&rft_id=info:doi/ L2 - http://people.stu.ca/~cheiron/membership/Cheiron%20Program%202009.upda ted.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteins, Lipids, and Their Dynamic Interaction Viewed by Nmr T2 - 2009 Keystone Symposia on Protein Dynamics, Allostery and Function (E3) AN - 40196824; 5184155 JF - 2009 Keystone Symposia on Protein Dynamics, Allostery and Function (E3) AU - Bax, Ad Y1 - 2009/06/23/ PY - 2009 DA - 2009 Jun 23 KW - N.M.R. KW - Lipids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40196824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Protein+Dynamics%2C+Allostery+and+Function+%28E3%29&rft.atitle=Proteins%2C+Lipids%2C+and+Their+Dynamic+Interaction+Viewed+by+Nmr&rft.au=Bax%2C+Ad&rft.aulast=Bax&rft.aufirst=Ad&rft.date=2009-06-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Protein+Dynamics%2C+Allostery+and+Function+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visualizing Transient Lowly-Populated Regions of the Free Energy Landscape of Macromolecules and Their Complexes by Paramagnetic Relaxation Enhancement T2 - 2009 Keystone Symposia on Protein Dynamics, Allostery and Function (E3) AN - 40196708; 5184153 JF - 2009 Keystone Symposia on Protein Dynamics, Allostery and Function (E3) AU - Clore, G Y1 - 2009/06/23/ PY - 2009 DA - 2009 Jun 23 KW - Landscape KW - Macromolecules KW - Free energy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40196708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Protein+Dynamics%2C+Allostery+and+Function+%28E3%29&rft.atitle=Visualizing+Transient+Lowly-Populated+Regions+of+the+Free+Energy+Landscape+of+Macromolecules+and+Their+Complexes+by+Paramagnetic+Relaxation+Enhancement&rft.au=Clore%2C+G&rft.aulast=Clore&rft.aufirst=G&rft.date=2009-06-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Protein+Dynamics%2C+Allostery+and+Function+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Public Talks and Science Listens: A Community-Based Participatory Approach to Characterizing Environmental Health Risk Perceptions and Assessing Recovery needs in the Wake of Hurricanes Katrina and Rita AN - 21116011; 11330929 AB - In response to the human health threats stemming from Hurricanes Katrina and Rita, interdisciplinary working groups representing P30-funded Centers of the National Institute Environmental Health Sciences were created to assess threats posed by mold, harmful alga blooms, chemical toxicants, and various infectious agents at selected sites throughout the hurricane impact zone. Because of proximity to impacted areas, UTMB NIEHS Center in Environmental Toxicology was charged with coordinating direct community outreach efforts, primarily in south Louisiana. In early October 2005, UTMB/NIEHS Center Community Outreach and Education Core, in collaboration with outreach counterparts at The University of Texas MD Anderson Cancer Center, Smithville TX/Center for Research in Environmental Disease sent two groups into southern Louisiana. One group used Lafourche Parish as a base to deliver humanitarian aid and assess local needs for additional supplies during local recovery/reclamation. A second group, ranging through New Iberia, New Orleans, Chalmette, rural Terrebonne, Lafourche and Jefferson Parishes and Baton Rouge met with community environmental leaders, emergency personnel and local citizens to 1) sample public risk perceptions, 2) evaluate the scope and reach of ongoing risk communication efforts, and 3) determine how the NIEHS could best collaborate with local groups in environmental health research and local capacity building efforts. This scoping survey identified specific information gaps limiting efficacy of risk communication, produced a community "wish list" of potential collaborative research projects. The project provided useful heuristics for disaster response and management planning and a platform for future collaborative efforts in environmental health assessment and risk communication with local advocacy groups in south Terrebonne-Lafourche parishes. JF - Environmental Health Insights AU - Sullivan, J AU - Parras, B AU - St. Marie, R AU - Subra, W AU - Petronella, S AU - Gorenstein, J AU - Fuchs-Young, R AU - Santa, R K AU - Chavarria, A AU - Ward, J AU - Diamond, P AD - University of Texas Medical Branch, Galveston/NIEHs Center in Environmental Toxicology, USA Y1 - 2009/06/23/ PY - 2009 DA - 2009 Jun 23 SP - 37 EP - 51 SN - 1178-6302, 1178-6302 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Health & Safety Science Abstracts KW - Risk assessment KW - Toxicants KW - environmental diseases KW - reclamation KW - Communication KW - Environmental health KW - Molds KW - Personnel KW - USA, Louisiana KW - USA, Louisiana, Baton Rouge KW - Toxicology KW - Disasters KW - USA, Louisiana, New Orleans KW - community involvement KW - carrying capacity KW - Cancer KW - Hurricanes KW - Education KW - Communications KW - Perception KW - Problem solving KW - Rural areas KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21116011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Insights&rft.atitle=Public+Talks+and+Science+Listens%3A+A+Community-Based+Participatory+Approach+to+Characterizing+Environmental+Health+Risk+Perceptions+and+Assessing+Recovery+needs+in+the+Wake+of+Hurricanes+Katrina+and+Rita&rft.au=Sullivan%2C+J%3BParras%2C+B%3BSt.+Marie%2C+R%3BSubra%2C+W%3BPetronella%2C+S%3BGorenstein%2C+J%3BFuchs-Young%2C+R%3BSanta%2C+R+K%3BChavarria%2C+A%3BWard%2C+J%3BDiamond%2C+P&rft.aulast=Sullivan&rft.aufirst=J&rft.date=2009-06-23&rft.volume=&rft.issue=&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Insights&rft.issn=11786302&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Hurricanes; Toxicants; Personnel; Perception; Communication; Problem solving; Molds; Cancer; reclamation; environmental diseases; Disasters; Environmental health; community involvement; carrying capacity; Education; Communications; Toxicology; Rural areas; USA, Louisiana; USA, Louisiana, Baton Rouge; USA, Louisiana, New Orleans ER - TY - CPAPER T1 - Stem Cell and Cancer Stem Cell Regulation in Adult Drosophila Kidney T2 - 2009 BIT's Annual 2nd World Cancer Congress AN - 40262352; 5220614 JF - 2009 BIT's Annual 2nd World Cancer Congress AU - Hou, Steve Y1 - 2009/06/22/ PY - 2009 DA - 2009 Jun 22 KW - Stem cells KW - Cancer KW - Kidneys KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40262352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.atitle=Stem+Cell+and+Cancer+Stem+Cell+Regulation+in+Adult+Drosophila+Kidney&rft.au=Hou%2C+Steve&rft.aulast=Hou&rft.aufirst=Steve&rft.date=2009-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ER Stress, Epigenetics and Cancer Therapy: A New Twist on an Old Tale T2 - 2009 BIT's Annual 2nd World Cancer Congress AN - 40258432; 5220724 JF - 2009 BIT's Annual 2nd World Cancer Congress AU - Ye, Yihong Y1 - 2009/06/22/ PY - 2009 DA - 2009 Jun 22 KW - Cancer KW - Stress KW - Epigenetics KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40258432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.atitle=ER+Stress%2C+Epigenetics+and+Cancer+Therapy%3A+A+New+Twist+on+an+Old+Tale&rft.au=Ye%2C+Yihong&rft.aulast=Ye&rft.aufirst=Yihong&rft.date=2009-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of Breast Cancer during Pregnancy: What Evidence Do We Have? T2 - 2009 BIT's Annual 2nd World Cancer Congress AN - 40257668; 5220599 JF - 2009 BIT's Annual 2nd World Cancer Congress AU - Azim Jr, Hatem Y1 - 2009/06/22/ PY - 2009 DA - 2009 Jun 22 KW - Pregnancy KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40257668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.atitle=Treatment+of+Breast+Cancer+during+Pregnancy%3A+What+Evidence+Do+We+Have%3F&rft.au=Azim+Jr%2C+Hatem&rft.aulast=Azim+Jr&rft.aufirst=Hatem&rft.date=2009-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Signatures of Signal Pathways and Transcriptional Controls in Heterogeneous Head and Neck Cancer Subsets Related to Tp53 Status T2 - 2009 BIT's Annual 2nd World Cancer Congress AN - 40257579; 5220759 JF - 2009 BIT's Annual 2nd World Cancer Congress AU - Chen, Zhong Y1 - 2009/06/22/ PY - 2009 DA - 2009 Jun 22 KW - Head and neck cancer KW - P53 protein KW - Transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40257579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.atitle=Molecular+Signatures+of+Signal+Pathways+and+Transcriptional+Controls+in+Heterogeneous+Head+and+Neck+Cancer+Subsets+Related+to+Tp53+Status&rft.au=Chen%2C+Zhong&rft.aulast=Chen&rft.aufirst=Zhong&rft.date=2009-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prostate Cancer Stem Cells: Biological Pathways Underlying Self-Renewal and Molecular Targeting T2 - 2009 BIT's Annual 2nd World Cancer Congress AN - 40257374; 5220699 JF - 2009 BIT's Annual 2nd World Cancer Congress AU - Hurt, Elaine Y1 - 2009/06/22/ PY - 2009 DA - 2009 Jun 22 KW - Stem cells KW - Prostate cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40257374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.atitle=Prostate+Cancer+Stem+Cells%3A+Biological+Pathways+Underlying+Self-Renewal+and+Molecular+Targeting&rft.au=Hurt%2C+Elaine&rft.aulast=Hurt&rft.aufirst=Elaine&rft.date=2009-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IKKa is Required to Maintain Skin Homeostasis and Prevent Skin Cancer T2 - 2009 BIT's Annual 2nd World Cancer Congress AN - 40257282; 5220667 JF - 2009 BIT's Annual 2nd World Cancer Congress AU - Hu, Yinling Y1 - 2009/06/22/ PY - 2009 DA - 2009 Jun 22 KW - Skin cancer KW - Homeostasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40257282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.atitle=IKKa+is+Required+to+Maintain+Skin+Homeostasis+and+Prevent+Skin+Cancer&rft.au=Hu%2C+Yinling&rft.aulast=Hu&rft.aufirst=Yinling&rft.date=2009-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TGF-beta Signaling and Cancer T2 - 2009 BIT's Annual 2nd World Cancer Congress AN - 40255773; 5220776 JF - 2009 BIT's Annual 2nd World Cancer Congress AU - Zhang, Ying Y1 - 2009/06/22/ PY - 2009 DA - 2009 Jun 22 KW - Cancer KW - Signal transduction KW - Transforming growth factor-b KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40255773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.atitle=TGF-beta+Signaling+and+Cancer&rft.au=Zhang%2C+Ying&rft.aulast=Zhang&rft.aufirst=Ying&rft.date=2009-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Monoclonal Antibodies Targeting the IGF System for Cancer Treatment T2 - 2009 BIT's Annual 2nd World Cancer Congress AN - 40254890; 5220811 JF - 2009 BIT's Annual 2nd World Cancer Congress AU - Feng, Yang Y1 - 2009/06/22/ PY - 2009 DA - 2009 Jun 22 KW - Cancer KW - Monoclonal antibodies KW - Insulin-like growth factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40254890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.atitle=Human+Monoclonal+Antibodies+Targeting+the+IGF+System+for+Cancer+Treatment&rft.au=Feng%2C+Yang&rft.aulast=Feng&rft.aufirst=Yang&rft.date=2009-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NGEP, A Potential Target for Prostate Cancer Immunotherapy, Identified by EST Database Mining T2 - 2009 BIT's Annual 2nd World Cancer Congress AN - 40247279; 5220807 JF - 2009 BIT's Annual 2nd World Cancer Congress AU - Bera, Tapan Y1 - 2009/06/22/ PY - 2009 DA - 2009 Jun 22 KW - Immunotherapy KW - Prostate cancer KW - Mining KW - Expressed sequence tags KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40247279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.atitle=NGEP%2C+A+Potential+Target+for+Prostate+Cancer+Immunotherapy%2C+Identified+by+EST+Database+Mining&rft.au=Bera%2C+Tapan&rft.aulast=Bera&rft.aufirst=Tapan&rft.date=2009-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+BIT%27s+Annual+2nd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2009/ScientificProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain imaging phenotypes linked to neurotrophic factor polymorphisms T2 - 2009 Gordon Research Conference on Neurotrophic Factors AN - 40303177; 5241549 JF - 2009 Gordon Research Conference on Neurotrophic Factors AU - Berman, Karen Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Brain KW - Neuroimaging KW - Neurotrophic factors KW - Gene polymorphism KW - Imaging techniques KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40303177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Neurotrophic+Factors&rft.atitle=Brain+imaging+phenotypes+linked+to+neurotrophic+factor+polymorphisms&rft.au=Berman%2C+Karen&rft.aulast=Berman&rft.aufirst=Karen&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Neurotrophic+Factors&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=neurtrop LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recognition of a translation arrest motif inside the ribosome tunnel T2 - 2009 Gordon Research Conference on Proteins AN - 40296873; 5241811 JF - 2009 Gordon Research Conference on Proteins AU - Yap, Mee-Ngan Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Arrests KW - Translation KW - Ribosomes KW - Tunnels KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40296873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Proteins&rft.atitle=Recognition+of+a+translation+arrest+motif+inside+the+ribosome+tunnel&rft.au=Yap%2C+Mee-Ngan&rft.aulast=Yap&rft.aufirst=Mee-Ngan&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Proteins&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=proteins LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Small RNA regulators of transcriptional regulators T2 - Mechanisms and Regulation of Prokaryotic Transcription AN - 40295829; 5239881 JF - Mechanisms and Regulation of Prokaryotic Transcription AU - Gottesman, Susan Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Transcription KW - RNA KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40295829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Mechanisms+and+Regulation+of+Prokaryotic+Transcription&rft.atitle=Small+RNA+regulators+of+transcriptional+regulators&rft.au=Gottesman%2C+Susan&rft.aulast=Gottesman&rft.aufirst=Susan&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Mechanisms+and+Regulation+of+Prokaryotic+Transcription&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11593.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How to Work your Way through NIH/NIAID Grants Process: Strategies and Opportunities T2 - Signal Transduction in the Immune System AN - 40293871; 5239918 JF - Signal Transduction in the Immune System AU - Mallia, Conrad Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Grants KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40293871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Signal+Transduction+in+the+Immune+System&rft.atitle=How+to+Work+your+Way+through+NIH%2FNIAID+Grants+Process%3A+Strategies+and+Opportunities&rft.au=Mallia%2C+Conrad&rft.aulast=Mallia&rft.aufirst=Conrad&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Signal+Transduction+in+the+Immune+System&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11702.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of HU in nucleoid structure and function T2 - Mechanisms and Regulation of Prokaryotic Transcription AN - 40293482; 5239870 JF - Mechanisms and Regulation of Prokaryotic Transcription AU - Adhya, Sankar Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Nucleoids KW - Structure-function relationships KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40293482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Mechanisms+and+Regulation+of+Prokaryotic+Transcription&rft.atitle=Role+of+HU+in+nucleoid+structure+and+function&rft.au=Adhya%2C+Sankar&rft.aulast=Adhya&rft.aufirst=Sankar&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Mechanisms+and+Regulation+of+Prokaryotic+Transcription&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11593.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The roles of transcription and RNA polymerase distribution on structure of the nucleoid in the absence of transertion T2 - Mechanisms and Regulation of Prokaryotic Transcription AN - 40293437; 5239868 JF - Mechanisms and Regulation of Prokaryotic Transcription AU - Jin, Ding Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Nucleoids KW - Transcription KW - DNA-directed RNA polymerase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40293437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Mechanisms+and+Regulation+of+Prokaryotic+Transcription&rft.atitle=The+roles+of+transcription+and+RNA+polymerase+distribution+on+structure+of+the+nucleoid+in+the+absence+of+transertion&rft.au=Jin%2C+Ding&rft.aulast=Jin&rft.aufirst=Ding&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Mechanisms+and+Regulation+of+Prokaryotic+Transcription&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11593.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nanobiology of atherosclerosis T2 - 2009 Gordon Research Conference on Atherosclerosis AN - 40293397; 5240796 JF - 2009 Gordon Research Conference on Atherosclerosis AU - Buxton, Denis Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Arteriosclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40293397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Atherosclerosis&rft.atitle=Nanobiology+of+atherosclerosis&rft.au=Buxton%2C+Denis&rft.aulast=Buxton&rft.aufirst=Denis&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Atherosclerosis&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=athero LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of ADP-Ribosylarginine Hydrolase (ARH1) on Cell Proliferation and Tumorigenesis T2 - NAD Metabolism and Signaling AN - 40293240; 5239798 JF - NAD Metabolism and Signaling AU - Kato, Jiro Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Cell proliferation KW - Tumorigenesis KW - Hydrolase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40293240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NAD+Metabolism+and+Signaling&rft.atitle=Effects+of+ADP-Ribosylarginine+Hydrolase+%28ARH1%29+on+Cell+Proliferation+and+Tumorigenesis&rft.au=Kato%2C+Jiro&rft.aulast=Kato&rft.aufirst=Jiro&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NAD+Metabolism+and+Signaling&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11652.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The promoter spacer influences transcription initiation via sigma 70 region 1.1 of E. coli RNA polymerase T2 - Mechanisms and Regulation of Prokaryotic Transcription AN - 40292151; 5239841 JF - Mechanisms and Regulation of Prokaryotic Transcription AU - Hinton, Deborah Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Spacer KW - Transcription initiation KW - Promoters KW - DNA-directed RNA polymerase KW - Transcription KW - Escherichia coli KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40292151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Mechanisms+and+Regulation+of+Prokaryotic+Transcription&rft.atitle=The+promoter+spacer+influences+transcription+initiation+via+sigma+70+region+1.1+of+E.+coli+RNA+polymerase&rft.au=Hinton%2C+Deborah&rft.aulast=Hinton&rft.aufirst=Deborah&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Mechanisms+and+Regulation+of+Prokaryotic+Transcription&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11593.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Participation of the ADP-Ribose-Acceptor Hydrolase (ARH) Gene Family in Diverse Signal Transduction Pathways T2 - NAD Metabolism and Signaling AN - 40287130; 5239808 JF - NAD Metabolism and Signaling AU - Moss, Joel Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Signal transduction KW - ARH protein KW - Hydrolase KW - Transduction KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40287130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NAD+Metabolism+and+Signaling&rft.atitle=Participation+of+the+ADP-Ribose-Acceptor+Hydrolase+%28ARH%29+Gene+Family+in+Diverse+Signal+Transduction+Pathways&rft.au=Moss%2C+Joel&rft.aulast=Moss&rft.aufirst=Joel&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NAD+Metabolism+and+Signaling&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11652.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lipid rafts domains and regulation of store-operated calcium entry T2 - 2009 Gordon Research Conference on Calcium Signalling AN - 40182450; 5184966 JF - 2009 Gordon Research Conference on Calcium Signalling AU - Ambudkar, Indu Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Lipid rafts KW - Calcium KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40182450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Calcium+Signalling&rft.atitle=Lipid+rafts+domains+and+regulation+of+store-operated+calcium+entry&rft.au=Ambudkar%2C+Indu&rft.aulast=Ambudkar&rft.aufirst=Indu&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Calcium+Signalling&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=calcium LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy AN - 21144267; 11353268 AB - Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately upon introduction of the materials into a physiological environment. The further biological response of the body is influenced by the nanoparticle-protein complex. The nanoparticle's composition and surface chemistry dictate the extent and specificity of protein binding. Protein binding is one of the key elements that affects biodistribution of the nanoparticles throughout the body. Here we review recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility. Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution. JF - Advanced Drug Delivery Reviews AU - Aggarwal, Parag AU - Hall, Jennifer B AU - McLeland, Christopher B AU - Dobrovolskaia, Marina A AU - McNeil, Scott E AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD 21702, USA, marina@mail.nih.gov Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 SP - 428 EP - 437 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 61 IS - 6 SN - 0169-409X, 0169-409X KW - Biotechnology and Bioengineering Abstracts KW - Protein binding KW - Immunology KW - Biodistribution KW - Biocompatibility KW - Plasma proteins KW - Drug delivery KW - Bioavailability KW - Physicochemical properties KW - nanoparticles KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21144267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Nanoparticle+interaction+with+plasma+proteins+as+it+relates+to+particle+biodistribution%2C+biocompatibility+and+therapeutic+efficacy&rft.au=Aggarwal%2C+Parag%3BHall%2C+Jennifer+B%3BMcLeland%2C+Christopher+B%3BDobrovolskaia%2C+Marina+A%3BMcNeil%2C+Scott+E&rft.aulast=Aggarwal&rft.aufirst=Parag&rft.date=2009-06-21&rft.volume=61&rft.issue=6&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2009.03.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Plasma proteins; Bioavailability; Drug delivery; Biocompatibility; Physicochemical properties; nanoparticles DO - http://dx.doi.org/10.1016/j.addr.2009.03.009 ER - TY - JOUR T1 - Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia. AN - 67403881; 19414673 AB - To conduct a phase II trial in chemoresistant hairy cell leukemia (HCL) with BL22, a recombinant anti-CD22 immunotoxin which showed phase I activity in HCL. Eligible patients had relapsed/refractory HCL and needed treatment based on blood counts. Patients were stratified into three groups: response to cladribine less than 1 year, those with a response lasting 1 to 4 years, or no response and uncontrolled infection. Patients received BL22 40 microg/kg every other day for three doses on cycle 1. Those achieving hematologic remission (HR), defined as neutrophils > or = 1,500/mm(3), hemoglobin > or = 11 g/dL, and platelets > or = 100,000/mm(3), were observed. Patients without HR were re-treated at 30 microg/kg every other day for three doses every 4 weeks beginning at least 8 weeks after cycle 1. Thirty-six patients were enrolled including 26, nine, and one in groups 1 to 3. The response after one cycle (CR, 25%; PR, 25%) improved when 56% were re-treated (CR, 47%; PR, 25%). CR rate was similar in groups 1 and 2 (P = .7). Twenty-two with baseline spleen height lower than 200 mm had higher CR (64% v 21%; P = .019) and OR rates (95% v 36%; P = .0002) compared to 14 with spleens either absent or higher than 200 mm. The only serious toxicity was reversible grade 3 hemolytic uremic syndrome, not requiring plasmapheresis, in two patients (6%). High neutralizing antibodies were observed in four patients (11%) and prevented re-treatment. BL22 activity in HCL is confirmed. Best responses to BL22 after cladribine failure are achieved before the patients develop massive splenomegaly or undergo splenectomy. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Kreitman, Robert J AU - Stetler-Stevenson, Maryalice AU - Margulies, Inger AU - Noel, Pierre AU - Fitzgerald, David J P AU - Wilson, Wyndham H AU - Pastan, Ira AD - Laboratory of Molecular Biology, Laboratory of Clinical Pathology, and Medicine Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. kreitmar@mail.nih.gov Y1 - 2009/06/20/ PY - 2009 DA - 2009 Jun 20 SP - 2983 EP - 2990 VL - 27 IS - 18 KW - Antibodies KW - 0 KW - Antineoplastic Agents KW - Enterotoxins KW - RFB4(dsFv)-PE38 recombinant immunotoxin KW - Cladribine KW - 47M74X9YT5 KW - Index Medicus KW - Prospective Studies KW - Humans KW - Cladribine -- therapeutic use KW - Adult KW - Treatment Outcome KW - Spleen KW - Drug Resistance KW - Aged KW - Middle Aged KW - Antineoplastic Agents -- therapeutic use KW - Male KW - Female KW - Antibodies -- therapeutic use KW - Antibodies -- administration & dosage KW - Leukemia, Hairy Cell -- drug therapy KW - Enterotoxins -- therapeutic use KW - Enterotoxins -- administration & dosage KW - Enterotoxins -- pharmacokinetics KW - Enterotoxins -- toxicity KW - Antibodies -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67403881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+II+trial+of+recombinant+immunotoxin+RFB4%28dsFv%29-PE38+%28BL22%29+in+patients+with+hairy+cell+leukemia.&rft.au=Kreitman%2C+Robert+J%3BStetler-Stevenson%2C+Maryalice%3BMargulies%2C+Inger%3BNoel%2C+Pierre%3BFitzgerald%2C+David+J+P%3BWilson%2C+Wyndham+H%3BPastan%2C+Ira&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-06-20&rft.volume=27&rft.issue=18&rft.spage=2983&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2008.20.2630 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-09 N1 - Date created - 2009-06-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11311-6 [18678888] Cancer Treat Res. 2008;142:193-209 [18283787] Clin Cancer Res. 2000 Apr;6(4):1476-87 [10778980] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Haematologica. 2001 Oct;86(10):1046-50 [11602410] Br J Haematol. 2001 Dec;115(3):609-11 [11736943] N Engl J Med. 2002 Aug 22;347(8):589-600 [12192020] J Clin Oncol. 2003 Mar 1;21(5):891-6 [12610190] Blood. 2003 Aug 1;102(3):810-3 [12663446] Blood. 2003 Dec 1;102(12):3906-11 [12816862] Cell Immunol. 1989 Jan;118(1):85-99 [2463099] Blood. 1993 Aug 15;82(4):1277-87 [7688993] Leukemia. 1994 Jul;8(7):1153-6 [7913513] Leukemia. 1994 Nov;8(11):2019-20 [7967746] J Clin Pathol. 1995 Oct;48(10):955-60 [8537498] Blood. 1996 Sep 15;88(6):1954-9 [8822913] Blood. 1997 Sep 1;90(5):2020-6 [9292538] Cancer Res. 1998 Mar 1;58(5):968-75 [9500458] Blood. 1998 Sep 15;92(6):1918-26 [9731048] Int J Cancer. 1999 Mar 31;81(1):148-55 [10077166] Blood. 1958 Jul;13(7):609-30 [13560561] J Clin Oncol. 2005 Sep 20;23(27):6719-29 [16061911] Hematol Oncol Clin North Am. 2006 Oct;20(5):1099-108 [16990110] Annu Rev Med. 2007;58:221-37 [17059365] Blood. 2009 Apr 16;113(16):3792-800 [18988862] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1200/JCO.2008.20.2630 ER - TY - JOUR T1 - Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis. AN - 67369994; 19386607 AB - Tubacin is a small molecule inhibitor of histone deacetylase 6 and blocks aggresome activity. We found that Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) cells were generally killed by lower doses of tubacin than EBV-transformed lymphoblastoid cells (LCLs) or EBV-negative BL cells. Tubacin induced apoptosis of LCLs, which was inhibited by pretreatment with a pancaspase inhibitor but not by butylated hydroxyanisole, which inhibits reactive oxygen species. In contrast, tubacin killed EBV-positive BL cells in a caspase-3-independent pathway that involved reactive oxygen species and was blocked by butylated hydroxyanisole. Previously, we showed that bortezomib, a proteasome inhibitor, induces apoptosis of EBV LCLs and that LCLs are killed by lower doses of bortezomib than EBV-positive BL cells. Here we found that the combination of bortezomib and tubacin acted in synergy to kill EBV-positive BL cells and LCLs. Tubacin or the combination of bortezomib and tubacin did not induce EBV lytic replication. These findings suggest that the combination of a proteasome inhibitor and an HDAC6 inhibitor may represent a useful strategy for the treatment of certain EBV-associated B cell lymphomas. JF - The Journal of biological chemistry AU - Kawada, Junichi AU - Zou, Ping AU - Mazitschek, Ralph AU - Bradner, James E AU - Cohen, Jeffrey I AD - Medical Virology Section, Laboratory of Clinical Infectious Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892-1888, USA. Y1 - 2009/06/19/ PY - 2009 DA - 2009 Jun 19 SP - 17102 EP - 17109 VL - 284 IS - 25 KW - Anilides KW - 0 KW - Boronic Acids KW - Enzyme Inhibitors KW - Histone Deacetylase Inhibitors KW - Hydroxamic Acids KW - Protease Inhibitors KW - Pyrazines KW - Reactive Oxygen Species KW - tubacin KW - Bortezomib KW - 69G8BD63PP KW - CASP3 protein, human KW - EC 3.4.22.- KW - Caspase 3 KW - HDAC6 protein, human KW - EC 3.5.1.98 KW - Histone Deacetylases KW - Index Medicus KW - Boronic Acids -- pharmacology KW - Reactive Oxygen Species -- metabolism KW - Protease Inhibitors -- pharmacology KW - Enzyme Inhibitors -- administration & dosage KW - Humans KW - Pyrazines -- pharmacology KW - Genes, Viral -- drug effects KW - Cell Line, Tumor KW - Pyrazines -- administration & dosage KW - Protease Inhibitors -- administration & dosage KW - Boronic Acids -- administration & dosage KW - Enzyme Inhibitors -- pharmacology KW - Drug Synergism KW - Cell Transformation, Viral KW - Caspase 3 -- metabolism KW - Herpesvirus 4, Human -- pathogenicity KW - B-Lymphocytes -- pathology KW - B-Lymphocytes -- metabolism KW - Burkitt Lymphoma -- virology KW - Anilides -- pharmacology KW - Burkitt Lymphoma -- pathology KW - B-Lymphocytes -- drug effects KW - B-Lymphocytes -- virology KW - Hydroxamic Acids -- administration & dosage KW - Herpesvirus 4, Human -- genetics KW - Apoptosis -- drug effects KW - Hydroxamic Acids -- pharmacology KW - Anilides -- administration & dosage KW - Burkitt Lymphoma -- drug therapy KW - Burkitt Lymphoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67369994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Tubacin+kills+Epstein-Barr+virus+%28EBV%29-Burkitt+lymphoma+cells+by+inducing+reactive+oxygen+species+and+EBV+lymphoblastoid+cells+by+inducing+apoptosis.&rft.au=Kawada%2C+Junichi%3BZou%2C+Ping%3BMazitschek%2C+Ralph%3BBradner%2C+James+E%3BCohen%2C+Jeffrey+I&rft.aulast=Kawada&rft.aufirst=Junichi&rft.date=2009-06-19&rft.volume=284&rft.issue=25&rft.spage=17102&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M809090200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-20 N1 - Date created - 2009-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Biol. 1998 Dec 28;143(7):1883-98 [9864362] J Virol. 2007 Sep;81(18):10029-36 [17626072] J Biol Chem. 2001 Mar 9;276(10):7320-6 [11058599] Curr Opin Oncol. 2001 Sep;13(5):360-7 [11555713] Trends Mol Med. 2002;8(4 Suppl):S49-54 [11927288] Nature. 2002 May 23;417(6887):455-8 [12024216] Mol Cell. 2002 May;9(5):1031-44 [12049739] Cell Motil Cytoskeleton. 2002 Sep;53(1):26-38 [12211113] EMBO J. 2002 Dec 16;21(24):6820-31 [12486003] Virology. 2002 Nov 25;303(2):345-63 [12490396] EMBO J. 2003 Mar 3;22(5):1168-79 [12606581] Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94 [12677000] Chem Biol. 2003 May;10(5):383-96 [12770821] Apoptosis. 2003 Aug;8(4):345-52 [12815277] Virus Genes. 1991 Apr;5(2):147-56 [1647567] J Biol Chem. 1997 May 16;272(20):13432-6 [9148968] Blood. 2003 Nov 15;102(10):3765-74 [12893773] Cell. 2003 Dec 12;115(6):727-38 [14675537] Clin Cancer Res. 2004 Jun 1;10(11):3839-52 [15173093] J Virol. 2004 Oct;78(20):11040-50 [15452224] J Natl Cancer Inst. 2004 Oct 6;96(19):1447-57 [15467034] Biomedicine. 1975 Jul;22(4):276-84 [179629] Adv Enzyme Regul. 1984;22:27-55 [6382953] Proc Natl Acad Sci U S A. 1987 Nov;84(22):8060-4 [2825176] J Virol. 1990 May;64(5):2309-18 [2157887] J Gen Virol. 1990 Jul;71 ( Pt 7):1481-95 [2165133] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):673-8 [15637150] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72 [15937109] Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4952-7 [16547133] Cancer Res. 2006 Apr 1;66(7):3773-81 [16585204] Cancer Res. 2006 Sep 1;66(17):8762-9 [16951192] Nat Rev Drug Discov. 2006 Sep;5(9):769-84 [16955068] J Cell Biochem. 2006 Dec 1;99(5):1420-30 [16817225] N Engl J Med. 2000 Aug 17;343(7):481-92 [10944566] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M809090200 ER - TY - JOUR T1 - Discernment of possible mechanisms of hepatotoxicity via biological processes over-represented by co-expressed genes. AN - 67463269; 19538742 AB - Hepatotoxicity is a form of liver injury caused by exposure to stressors. Genomic-based approaches have been used to detect changes in transcription in response to hepatotoxicants. However, there are no straightforward ways of using co-expressed genes anchored to a phenotype or constrained by the experimental design for discerning mechanisms of a biological response. Through the analysis of a gene expression dataset containing 318 liver samples from rats exposed to hepatotoxicants and leveraging alanine aminotransferase (ALT), a serum enzyme indicative of liver injury as the phenotypic marker, we identified biological processes and molecular pathways that may be associated with mechanisms of hepatotoxicity. Our analysis used an approach called Coherent Co-expression Biclustering (cc-Biclustering) for clustering a subset of genes through a coherent (consistency) measure within each group of samples representing a subset of experimental conditions. Supervised biclustering identified 87 genes co-expressed and correlated with ALT in all the samples exposed to the chemicals. None of the over-represented pathways related to liver injury. However, biclusters with subsets of samples exposed to one of the 7 hepatotoxicants, but not to a non-toxic isomer, contained co-expressed genes that represented pathways related to a stress response. Unsupervised biclustering of the data resulted in 1) four to five times more genes within the bicluster containing all the samples exposed to the chemicals, 2) biclusters with co-expression of genes that discerned 1,4 dichlorobenzene (a non-toxic isomer at low and mid doses) from the other chemicals, pathways and biological processes that underlie liver injury and 3) a bicluster with genes up-regulated in an early response to toxic exposure. We obtained clusters of co-expressed genes that over-represented biological processes and molecular pathways related to hepatotoxicity in the rat. The mechanisms involved in the response of the liver to the exposure to 1,4-dichlorobenzene suggest non-genotoxicity whereas the exposure to the hepatotoxicants could be DNA damaging leading to overall genomic instability and activation of cell cycle check point signaling. In addition, key pathways and biological processes representative of an inflammatory response, energy production and apoptosis were impacted by the hepatotoxicant exposures that manifested liver injury in the rat. JF - BMC genomics AU - Chou, Jeff W AU - Bushel, Pierre R AD - Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. jchou@wfubmc.edu Y1 - 2009/06/18/ PY - 2009 DA - 2009 Jun 18 SP - 272 VL - 10 KW - Biomarkers KW - 0 KW - Chlorobenzenes KW - 4-dichlorobenzene KW - D149TYB5MK KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Alanine Transaminase -- metabolism KW - Gene Expression KW - Cluster Analysis KW - Male KW - Chlorobenzenes -- toxicity KW - Liver -- drug effects KW - Liver -- metabolism KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67463269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Discernment+of+possible+mechanisms+of+hepatotoxicity+via+biological+processes+over-represented+by+co-expressed+genes.&rft.au=Chou%2C+Jeff+W%3BBushel%2C+Pierre+R&rft.aulast=Chou&rft.aufirst=Jeff&rft.date=2009-06-18&rft.volume=10&rft.issue=&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2F1471-2164-10-272 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-24 N1 - Date created - 2009-07-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Immunity. 2001 Sep;15(3):375-85 [11567628] Proc Int Conf Intell Syst Mol Biol. 2000;8:93-103 [10977070] J Biol Chem. 2003 May 9;278(19):16726-31 [12609979] Genome Biol. 2003;4(5):P3 [12734009] Toxicol Sci. 2004 Jul;80(1):193-202 [15084756] NIDA Res Monogr. 1993;125:3-24 [8341367] Nat Rev Drug Discov. 2005 Jun;4(6):489-99 [15931258] Toxicol Sci. 2005 Aug;86(2):453-69 [15901911] Toxicol Sci. 2005 Sep;87(1):296-305 [15976192] Hepatology. 2006 Feb;43(2 Suppl 1):S45-53 [16447274] N Engl J Med. 2006 Feb 16;354(7):731-9 [16481640] Environ Health Perspect. 2006 Apr;114(4):553-9 [16581545] IEEE/ACM Trans Comput Biol Bioinform. 2005 Oct-Dec;2(4):339-54 [17044171] IEEE/ACM Trans Comput Biol Bioinform. 2004 Jan-Mar;1(1):24-45 [17048406] Bioinformatics. 2007 Jan 1;23(1):50-6 [17090578] Environ Health Perspect. 2007 Apr;115(4):572-8 [17450226] J Biol Chem. 2007 May 25;282(21):15851-61 [17369260] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18211-6 [17984051] Biochem Pharmacol. 2008 Jan 15;75(2):538-51 [17945193] Nucleic Acids Res. 2008 Jan;36(Database issue):D892-900 [17962311] Biochem Pharmacol. 2008 Mar 1;75(5):1230-9 [18068688] Mol Cell Biol. 2008 Apr;28(7):2201-12 [18250157] BMC Bioinformatics. 2008;9:210 [18433478] J Neurosci. 2008 Jun 11;28(24):6068-78 [18550749] BMC Genomics. 2008;9:288 [18558008] Genome Biol. 2008;9(6):R100 [18570634] BMC Genomics. 2008;9:419 [18796159] Ann Intern Med. 2002 Dec 17;137(12):947-54 [12484709] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2164-10-272 ER - TY - JOUR T1 - IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. AN - 67398777; 19380868 AB - Interleukin 7 (IL-7) is a common gamma chain receptor cytokine implicated in thymopoiesis and in peripheral expansion and survival of T lymphocytes. The safety and activity of recombinant human IL-7 (rhIL-7) administration were therefore examined in HIV-infected persons. In this prospective randomized placebo-controlled study, a single subcutaneous dose of rhIL-7 was well tolerated with biologic activity demonstrable at 3 microg/kg and a maximum tolerated dose of 30 microg/kg. Injection site reactions and transient elevations of liver function tests were the most notable side effects. Transient increases in plasma HIV-RNA levels were observed in 6 of 11 IL-7-treated patients. Recombinant hIL-7 induced CD4 and CD8 T cells to enter cell cycle; cell-cycle entry was also confirmed in antigen-specific CD8 T cells. Administration of rhIL-7 led to transient down-regulation of the IL-7 receptor alpha chain (CD127) in both CD4(+) and CD8(+) T cells. Single-dose rhIL-7 increased the numbers of circulating CD4(+) and CD8(+) T cells, predominantly of central memory phenotype. The frequency of CD4(+) T cells with a regulatory T-cell phenotype (CD25(high) CD127(low)) did not change after rhIL-7 administration. Thus, rhIL-7 has a biologic and toxicity profile suggesting a potential for therapeutic trials in HIV infection and other settings of lymphopenia. This clinical trial has been registered at http://www.clinicaltrials.gov under NCT0099671. JF - Blood AU - Sereti, Irini AU - Dunham, Richard M AU - Spritzler, John AU - Aga, Evgenia AU - Proschan, Michael A AU - Medvik, Kathy AU - Battaglia, Catherine A AU - Landay, Alan L AU - Pahwa, Savita AU - Fischl, Margaret A AU - Asmuth, David M AU - Tenorio, Allan R AU - Altman, John D AU - Fox, Lawrence AU - Moir, Susan AU - Malaspina, Angela AU - Morre, Michel AU - Buffet, Renaud AU - Silvestri, Guido AU - Lederman, Michael M AU - ACTG 5214 Study Team AD - National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. isereti@niaid.nih.gov ; ACTG 5214 Study Team Y1 - 2009/06/18/ PY - 2009 DA - 2009 Jun 18 SP - 6304 EP - 6314 VL - 113 IS - 25 KW - IL7 protein, human KW - 0 KW - Interleukin-7 KW - Interleukin-7 Receptor alpha Subunit KW - Recombinant Proteins KW - Abridged Index Medicus KW - Index Medicus KW - CD4-Positive T-Lymphocytes -- cytology KW - CD8-Positive T-Lymphocytes -- drug effects KW - T-Lymphocytes, Regulatory -- drug effects KW - CD8-Positive T-Lymphocytes -- metabolism KW - Humans KW - CD4-Positive T-Lymphocytes -- immunology KW - Recombinant Proteins -- blood KW - Interleukin-7 Receptor alpha Subunit -- genetics KW - Lymphocyte Count KW - Chemical and Drug Induced Liver Injury -- etiology KW - Interleukin-7 Receptor alpha Subunit -- biosynthesis KW - Adult KW - Recombinant Proteins -- adverse effects KW - Down-Regulation -- drug effects KW - Recombinant Proteins -- therapeutic use KW - Male KW - Recombinant Proteins -- administration & dosage KW - Recombinant Proteins -- pharmacology KW - Immunologic Memory -- drug effects KW - CD4-Positive T-Lymphocytes -- drug effects KW - Viral Load KW - CD8-Positive T-Lymphocytes -- cytology KW - CD4-Positive T-Lymphocytes -- metabolism KW - CD8-Positive T-Lymphocytes -- immunology KW - T-Lymphocytes, Regulatory -- cytology KW - Middle Aged KW - Maximum Tolerated Dose KW - Cell Cycle -- drug effects KW - Female KW - T-Lymphocytes, Regulatory -- immunology KW - T-Lymphocyte Subsets -- cytology KW - T-Lymphocyte Subsets -- drug effects KW - HIV Infections -- immunology KW - T-Lymphocyte Subsets -- immunology KW - Interleukin-7 -- blood KW - HIV Infections -- drug therapy KW - Interleukin-7 -- therapeutic use KW - Interleukin-7 -- administration & dosage KW - Interleukin-7 -- pharmacology KW - HIV-1 KW - Interleukin-7 -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67398777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=IL-7+administration+drives+T+cell-cycle+entry+and+expansion+in+HIV-1+infection.&rft.au=Sereti%2C+Irini%3BDunham%2C+Richard+M%3BSpritzler%2C+John%3BAga%2C+Evgenia%3BProschan%2C+Michael+A%3BMedvik%2C+Kathy%3BBattaglia%2C+Catherine+A%3BLanday%2C+Alan+L%3BPahwa%2C+Savita%3BFischl%2C+Margaret+A%3BAsmuth%2C+David+M%3BTenorio%2C+Allan+R%3BAltman%2C+John+D%3BFox%2C+Lawrence%3BMoir%2C+Susan%3BMalaspina%2C+Angela%3BMorre%2C+Michel%3BBuffet%2C+Renaud%3BSilvestri%2C+Guido%3BLederman%2C+Michael+M%3BACTG+5214+Study+Team&rft.aulast=Sereti&rft.aufirst=Irini&rft.date=2009-06-18&rft.volume=113&rft.issue=25&rft.spage=6304&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2008-10-186601 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-20 N1 - Date created - 2009-06-22 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00099671; ClinicalTrials.gov N1 - SuppNotes - Cited By: Blood. 2004 Aug 1;104(3):775-80 [15090457] Science. 1996 Oct 4;274(5284):94-6 [8810254] Nat Genet. 1998 Dec;20(4):394-7 [9843216] J Clin Invest. 2005 Jan;115(1):128-37 [15630452] J Immunol. 2005 Mar 1;174(5):2900-9 [15728501] J Infect Dis. 2005 Jul 1;192(1):62-70 [15942895] J Immunol. 2005 Jul 1;175(1):162-70 [15972643] J Clin Invest. 2005 Jul;115(7):1839-47 [15937547] Expert Opin Biol Ther. 2005 Nov;5(11):1421-6 [16255646] J Immunol. 2006 Jan 15;176(2):914-22 [16393976] J Infect Dis. 2006 Feb 15;193(4):505-14 [16425129] J Infect Dis. 2006 Mar 15;193(6):879-87 [16479523] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2262-7 [16461915] J Immunother. 2006 May-Jun;29(3):313-9 [16699374] J Exp Med. 2006 Jul 10;203(7):1693-700 [16818676] J Exp Med. 2006 Jul 10;203(7):1701-11 [16818678] J Acquir Immune Defic Syndr. 2006 Aug 15;42(5):537-44 [16837861] Curr Drug Targets. 2006 Dec;7(12):1571-82 [17168832] Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19436-41 [17158796] Nat Rev Immunol. 2007 Feb;7(2):144-54 [17259970] Science. 1993 Dec 17;262(5141):1877-80 [8266077] Blood. 1996 Sep 1;88(5):1887-94 [8781449] J Immunol. 2003 Oct 15;171(8):4447-53 [14530372] Blood. 2003 Mar 15;101(6):2294-9 [12411295] Blood. 2002 Jun 1;99(11):3892-904 [12010786] JAMA. 2000 Jul 12;284(2):183-9 [10889591] J Exp Med. 2008 Jul 7;205(7):1701-14 [18573906] J Exp Med. 2007 Sep 3;204(9):2171-85 [17724130] Blood. 2007 Mar 1;109(5):2086-8 [17053062] J Infect Dis. 2000 Oct;182(4):1063-9 [10979900] Nat Med. 2001 Jan;7(1):73-9 [11135619] Nat Immunol. 2000 Oct;1(4):285-9 [11017098] Blood. 2001 May 15;97(10):2983-90 [11342421] Clin Infect Dis. 2001 Jun 15;32(12):1738-55 [11360217] Eur J Immunol. 2001 May;31(5):1351-60 [11465092] J Exp Med. 2002 Mar 18;195(6):789-94 [11901204] Control Clin Trials. 2002 Apr;23(2):198-220 [11943448] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1182/blood-2008-10-186601 ER - TY - JOUR T1 - Pesticide exposure and risk of monoclonal gammopathy of undetermined significance in the Agricultural Health Study. AN - 67396524; 19387005 AB - Pesticides are associated with excess risk of multiple myeloma, albeit inconclusively. We included 678 men (30-94 years) from a well-characterized prospective cohort of restricted-use pesticide applicators to assess the risk of monoclonal gammopathy of undetermined significance (MGUS). Serum samples from all subjects were analyzed by electrophoresis performed on agarose gel; samples with a discrete or localized band were subjected to immunofixation. Age-adjusted prevalence estimates of MGUS were compared with MGUS prevalence in 9469 men from Minnesota. Associations between pesticide exposures and MGUS prevalence were assessed by logistic regression models adjusted for age and education level. Among study participants older than 50 years (n = 555), 38 were found to have MGUS, yielding a prevalence of 6.8% (95% CI, 5.0%-9.3%). Compared with men from Minnesota, the age-adjusted prevalence of MGUS was 1.9-fold (95% CI, 1.3- to 2.7-fold) higher among male pesticide applicators. Among applicators, a 5.6-fold (95% CI, 1.9- to 16.6-fold), 3.9-fold (95% CI, 1.5- to 10.0-fold), and 2.4-fold (95% CI, 1.1- to 5.3-fold) increased risk of MGUS prevalence was observed among users of the chlorinated insecticide dieldrin, the fumigant mixture carbon-tetrachloride/carbon disulfide, and the fungicide chlorothalonil, respectively. In summary, the prevalence of MGUS among pesticide applicators was twice that in a population-based sample of men from Minnesota, adding support to the hypothesis that specific pesticides are causatively linked to myelomagenesis. JF - Blood AU - Landgren, Ola AU - Kyle, Robert A AU - Hoppin, Jane A AU - Beane Freeman, Laura E AU - Cerhan, James R AU - Katzmann, Jerry A AU - Rajkumar, S Vincent AU - Alavanja, Michael C AD - Division of Cancer Epidemiology and Genetics, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. landgreo@mail.nih.gov Y1 - 2009/06/18/ PY - 2009 DA - 2009 Jun 18 SP - 6386 EP - 6391 VL - 113 IS - 25 KW - Nitriles KW - 0 KW - Pesticides KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Dieldrin KW - I0246D2ZS0 KW - tetrachloroisophthalonitrile KW - J718M71A7A KW - Carbon Disulfide KW - S54S8B99E8 KW - Abridged Index Medicus KW - Index Medicus KW - Carbon Disulfide -- adverse effects KW - Age Factors KW - Humans KW - Aged KW - North Carolina -- epidemiology KW - Carbon Tetrachloride -- adverse effects KW - Prospective Studies KW - Aged, 80 and over KW - Adult KW - Cohort Studies KW - Sampling Studies KW - Electrophoresis, Agar Gel KW - Middle Aged KW - Nitriles -- adverse effects KW - Dieldrin -- adverse effects KW - Male KW - Iowa -- epidemiology KW - Prevalence KW - Blood Protein Electrophoresis KW - Paraproteinemias -- epidemiology KW - Occupational Exposure KW - Paraproteinemias -- chemically induced KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- chemically induced KW - Pesticides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67396524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Pesticide+exposure+and+risk+of+monoclonal+gammopathy+of+undetermined+significance+in+the+Agricultural+Health+Study.&rft.au=Landgren%2C+Ola%3BKyle%2C+Robert+A%3BHoppin%2C+Jane+A%3BBeane+Freeman%2C+Laura+E%3BCerhan%2C+James+R%3BKatzmann%2C+Jerry+A%3BRajkumar%2C+S+Vincent%3BAlavanja%2C+Michael+C&rft.aulast=Landgren&rft.aufirst=Ola&rft.date=2009-06-18&rft.volume=113&rft.issue=25&rft.spage=6386&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2009-02-203471 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-20 N1 - Date created - 2009-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Epidemiol. 1986 Sep;15(3):321-5 [3771067] Blood. 2009 Jul 23;114(4):791-5 [19182202] Am J Ind Med. 1988;14(2):167-76 [3207102] Int J Cancer. 1989 Apr 15;43(4):554-9 [2703267] Aust N Z J Med. 1988 Oct;18(6):774-9 [3242463] Br J Cancer. 1989 Sep;60(3):385-8 [2789947] Cancer. 1989 Dec 1;64(11):2381-6 [2804930] Arch Environ Health. 1990 May-Jun;45(3):155-62 [2386420] Am J Ind Med. 1990;18(2):133-48 [2206046] Am J Ind Med. 1990;18(3):295-301 [2220834] Br J Ind Med. 1992 Feb;49(2):95-103 [1536825] Scand J Work Environ Health. 1992 Aug;18(4):209-15 [1411362] Cancer Causes Control. 1992 Nov;3(6):555-68 [1420859] Int J Cancer. 1993 Mar 12;53(5):740-5 [8449597] Am J Ind Med. 1993 Apr;23(4):629-39 [8338527] Cancer Causes Control. 1993 Mar;4(2):153-6 [8481493] Am J Ind Med. 1993 May;23(5):729-42 [8506851] J Occup Med. 1994 Nov;36(11):1210-21 [7861265] Epidemiology. 2001 Jan;12(1):78-87 [11138825] Epidemiology. 2002 Jan;13(1):94-9 [11805592] N Engl J Med. 2002 Feb 21;346(8):564-9 [11856795] Am J Ind Med. 2002 Nov;42(5):410-20 [12382254] Br J Haematol. 2003 Jun;121(5):749-57 [12780789] Annu Rev Public Health. 2004;25:155-97 [15015917] Scand J Work Environ Health. 2004 Jun;30(3):215-22 [15250650] J Natl Cancer Inst. 2004 Sep 15;96(18):1375-82 [15367570] N Engl J Med. 2004 Oct 28;351(18):1860-73 [15509819] Am J Epidemiol. 1971 Oct;94(4):507-10 [5165015] J Natl Cancer Inst. 1984 Feb;72(2):251-5 [6582313] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Cancer Causes Control. 1997 Jan;8(1):25-33 [9051319] Am J Ind Med. 1997 Nov;32(5):510-6 [9327075] Cancer Causes Control. 1998 May;9(3):311-9 [9684711] J Natl Cancer Inst. 2004 Dec 1;96(23):1781-9 [15572760] Environ Health Perspect. 2005 Jan;113(1):49-54 [15626647] Scand J Work Environ Health. 2005;31 Suppl 1:39-45; discussion 5-7 [16190148] N Engl J Med. 2006 Mar 30;354(13):1362-9 [16571879] Environ Health Perspect. 2009 Apr;117(4):581-6 [19440497] Blood. 2009 May 28;113(22):5412-7 [19179464] Br J Cancer. 1988 May;57(5):516-20 [3395559] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2009-02-203471 ER - TY - JOUR T1 - Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha. AN - 67375869; 19467232 AB - Nuclear xenobiotic receptor CAR activates transcription of the CYP2B6 gene by directly binding to the distal enhancer PB responsive enhancer module (PBREM). This CAR-mediated activation is synergized by transcription factors early growth response 1 (EGR1) and hepatocyte-enriched nuclear factor 4alpha (HNF4alpha) that bind to the proximal element OA response element KI (OARE(KI)) [Inoue, K., & Negishi, M. (2008). Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene. J. Biol. Chem. 283, 10425-10432]. Two additional EGR1 binding sites have now been found just downstream from PBREM. Internal deletion of EGR1 sites within the context of the -1.8 kb CYP2B6 promoter, which contains both PBREM and OARE(KI), revealed that the distal and proximal EGR1 sites are essential for EGR1 to synergize CAR-mediated transcription. Chromatin conformation capture 3C assays demonstrated that ERG1 may loop the distal PBREM towards the proximal OARE(KI) so that together, CAR and HNF4alpha synergistically activate the CYP2B6 promoter. JF - FEBS letters AU - Inoue, Kaoru AU - Negishi, Masahiko AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/06/18/ PY - 2009 DA - 2009 Jun 18 SP - 2126 EP - 2130 VL - 583 IS - 12 KW - CLMP protein, human KW - 0 KW - Coxsackie and Adenovirus Receptor-Like Membrane Protein KW - DNA Primers KW - EGR1 protein, human KW - Early Growth Response Protein 1 KW - HNF4A protein, human KW - Hepatocyte Nuclear Factor 4 KW - Receptors, Virus KW - Recombinant Proteins KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP2B6 protein, human KW - Cytochrome P-450 CYP2B6 KW - Oxidoreductases, N-Demethylating KW - EC 1.5.- KW - Index Medicus KW - DNA Primers -- genetics KW - Humans KW - Receptor Cross-Talk KW - Recombinant Proteins -- genetics KW - Transcriptional Activation KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Promoter Regions, Genetic KW - Transfection KW - Recombinant Proteins -- metabolism KW - In Vitro Techniques KW - Binding Sites -- genetics KW - Cell Line KW - Hepatocytes -- metabolism KW - Oxidoreductases, N-Demethylating -- genetics KW - Early Growth Response Protein 1 -- metabolism KW - Early Growth Response Protein 1 -- genetics KW - Receptors, Virus -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Hepatocyte Nuclear Factor 4 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67375869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Early+growth+response+1+loops+the+CYP2B6+promoter+for+synergistic+activation+by+the+distal+and+proximal+nuclear+receptors+CAR+and+HNF4alpha.&rft.au=Inoue%2C+Kaoru%3BNegishi%2C+Masahiko&rft.aulast=Inoue&rft.aufirst=Kaoru&rft.date=2009-06-18&rft.volume=583&rft.issue=12&rft.spage=2126&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=1873-3468&rft_id=info:doi/10.1016%2Fj.febslet.2009.05.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-02 N1 - Date created - 2009-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Pharmacol Toxicol. 2001;41:123-43 [11264453] Mol Pharmacol. 2008 Sep;74(3):913-23 [18552123] Mol Cell Biol. 1993 Nov;13(11):6858-65 [8413279] J Biol Chem. 1994 Mar 18;269(11):8176-81 [8132543] Mol Cell Biol. 1998 Oct;18(10):5652-8 [9742082] J Biol Chem. 1999 Mar 5;274(10):6043-6 [10037683] Mol Cell Biol. 1999 Sep;19(9):6318-22 [10454578] J Biol Chem. 2005 Feb 4;280(5):3458-66 [15563456] J Pharmacol Exp Ther. 2005 Sep;314(3):1125-33 [15919766] Mol Pharmacol. 2005 Sep;68(3):747-57 [15933212] Oncogene. 2006 Mar 13;25(11):1679-91 [16550168] Nat Protoc. 2007;2(7):1722-33 [17641637] Nat Protoc. 2008;3(2):303-13 [18274532] J Biol Chem. 2008 Mar 28;283(13):8164-72 [18252719] Mol Endocrinol. 2008 Apr;22(4):813-22 [18174357] J Biol Chem. 2008 Apr 18;283(16):10425-32 [18303024] Mol Cell Biol. 1993 Aug;13(8):4556-71 [8336701] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.febslet.2009.05.031 ER - TY - JOUR T1 - Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. AN - 67405467; 19482936 AB - Overactivation of NMDA receptors (NMDARs) is a critical early step in glutamate-evoked excitotoxic injury of CNS neurons. Distinct NMDAR-coupled pathways specified by, for example, receptor location or subunit composition seem to govern glutamate-induced excitotoxic death, but there is much uncertainty concerning the underlying mechanisms of pathway selection. Here we ask whether, and if so how, route-specific vulnerability is coupled to Ca(2+) overload and mitochondrial dysfunction, which is also a known, central component of exitotoxic injury. In cultured hippocampal neurons, overactivation of only extrasynaptic NMDARs resulted in Ca(2+) entry strong enough to promote Ca(2+) overload, which subsequently leads to mitochondrial dysfunction and cell death. Receptor composition per se appears not to be a primary factor for specifying signal coupling, as NR2B inhibition abolished Ca(2+) loading and was protective only in predominantly NR2B-expressing young neurons. In older neurons expressing comparable levels of NR2A- and NR2B-containing NMDARs, amelioration of Ca(2+) overload required the inhibition of extrasynaptic receptors containing both NR2 subunits. Prosurvival synaptic stimuli also evoked Ca(2+) entry through both N2A- and NR2B-containing NMDARs, but, in contrast to excitotoxic activation of extrasynaptic NMDARs, produced only low-amplitude cytoplasmic Ca(2+) spikes and modest, nondamaging mitochondrial Ca(2+) accumulation. The results--showing that the various routes of excitotoxic Ca(2+) entry converge on a common pathway involving Ca(2+) overload-induced mitochondrial dysfunction--reconcile and unify many aspects of the "route-specific" and "calcium load-dependent" views of exitotoxic injury. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Stanika, Ruslan I AU - Pivovarova, Natalia B AU - Brantner, Christine A AU - Watts, Charlotte A AU - Winters, Christine A AU - Andrews, S Brian AD - Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/06/16/ PY - 2009 DA - 2009 Jun 16 SP - 9854 EP - 9859 VL - 106 IS - 24 KW - Glutamates KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Microscopy, Fluorescence KW - Ion Channel Gating KW - Animals KW - Blotting, Western KW - Cells, Cultured KW - Hippocampus -- metabolism KW - Microscopy, Electron KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Synapses -- metabolism KW - Ion Transport KW - Hippocampus -- drug effects KW - Calcium -- metabolism KW - Mitochondria -- metabolism KW - Glutamates -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67405467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Coupling+diverse+routes+of+calcium+entry+to+mitochondrial+dysfunction+and+glutamate+excitotoxicity.&rft.au=Stanika%2C+Ruslan+I%3BPivovarova%2C+Natalia+B%3BBrantner%2C+Christine+A%3BWatts%2C+Charlotte+A%3BWinters%2C+Christine+A%3BAndrews%2C+S+Brian&rft.aulast=Stanika&rft.aufirst=Ruslan&rft.date=2009-06-16&rft.volume=106&rft.issue=24&rft.spage=9854&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0903546106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-14 N1 - Date created - 2009-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Jan 1;20(1):22-33 [10627577] J Neurosci. 2000 Mar 15;20(6):2094-103 [10704483] J Neurosci. 2000 Dec 1;20(23):8831-7 [11102491] J Neurophysiol. 2001 Jan;85(1):399-406 [11152740] Nat Neurosci. 2002 May;5(5):405-14 [11953750] Science. 2002 Oct 25;298(5594):846-50 [12399596] J Neurosci. 2002 Dec 15;22(24):10653-61 [12486158] Trends Neurosci. 2003 Feb;26(2):81-9 [12536131] Cell Calcium. 2003 Oct-Nov;34(4-5):325-37 [12909079] Curr Mol Med. 2004 Mar;4(2):149-77 [15032711] J Neurosci. 2004 Jun 16;24(24):5611-22 [15201334] Cell Calcium. 2004 Sep-Oct;36(3-4):257-64 [15261481] Mol Aspects Med. 2004 Aug;25(4):365-451 [15302203] J Neurobiol. 1992 Nov;23(9):1261-76 [1361523] Ann N Y Acad Sci. 1994 Dec 15;747:162-71 [7847669] J Neurosci. 1997 Sep 1;17(17):6669-77 [9254679] J Neurosci. 1998 Oct 1;18(19):7727-38 [9742143] J Neurophysiol. 1998 Nov;80(5):2688-98 [9819273] J Neurosci. 2005 Jan 12;25(2):308-17 [15647474] J Neurosci. 2006 Jan 18;26(3):981-90 [16421318] J Neurophysiol. 2006 Mar;95(3):1727-34 [16319212] J Neurosci. 2006 Mar 15;26(11):2956-63 [16540573] FEBS J. 2006 May;273(10):2077-99 [16649987] J Biol Chem. 2006 May 26;281(21):14864-74 [16551630] J Neurosci. 2007 Mar 14;27(11):2846-57 [17360906] Brain Res. 2007 Jun 2;1151:20-31 [17433272] Neuropharmacology. 2007 Jul;53(1):10-7 [17570444] J Physiol. 2007 Oct 15;584(Pt 2):509-19 [17717018] J Neurosci Res. 2007 Nov 15;85(15):3206-12 [17455297] J Physiol. 2007 Dec 15;585(Pt 3):741-58 [17947304] Cell Calcium. 2008 Mar;43(3):296-306 [17764739] J Neurochem. 2008 Mar;104(6):1686-99 [18036152] J Neurosci. 2008 May 7;28(19):5029-39 [18463256] Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):953-64 [18471431] J Neurosci. 2008 Oct 15;28(42):10696-710 [18923045] Brain Res. 1999 Dec 4;849(1-2):97-108 [10592291] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0903546106 ER - TY - JOUR T1 - Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs AN - 20609763; 9316990 AB - Standardized green tea extract was evaluated for exposure and toxicity in Beagle dogs following oral dosing by capsules. The main component (-)-epigallocatechin gallate (EGCG) accounted for 56-72% of the material. A 9-month chronic study (0, 200, 500, and 1000mg /kg/day) was done in fasted dogs to take advantage of the reported improved catechin bioavailability with fasting. Extensive morbidity, mortality, and pathology of many major organs led to its early termination at 6.5 months and prevented identification of the toxicity mechanisms. A follow-up 13-week study examined the exposure to and toxicity of the extract. In general, toxicities were less severe than in the chronic study during the same interval. Dosing in a fed state resulted in considerably lower and less variable exposure than found under fasted conditions. Toxicity was less frequent and of lesser severity with lower exposure but limited sample size and large variability prevented reaching that definitive conclusion. Differences in mortality and morbidity between the preliminary terminated chronic and follow-up subchronic studies with the same dose of the same drug lot and similar exposure were not fully resolved as there may be other as yet unclear confounding factors. detection JF - Toxicology AU - Kapetanovic, I M AU - Crowell, JA AU - Krishnaraj, R AU - Zakharov, A AU - Lindeblad, M AU - Lyubimov, A AD - Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd., Rm. 2116, Bethesda, MD 20892, United States, kapetani@mail.nih.gov Y1 - 2009/06/16/ PY - 2009 DA - 2009 Jun 16 SP - 28 EP - 36 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 260 IS - 1-3 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Mortality KW - epigallocatechin-3-gallate KW - Bioavailability KW - Polyphenols KW - green tea KW - Catechin KW - Toxicity KW - Fasting KW - Drugs KW - Morbidity KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20609763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Exposure+and+toxicity+of+green+tea+polyphenols+in+fasted+and+non-fasted+dogs&rft.au=Kapetanovic%2C+I+M%3BCrowell%2C+JA%3BKrishnaraj%2C+R%3BZakharov%2C+A%3BLindeblad%2C+M%3BLyubimov%2C+A&rft.aulast=Kapetanovic&rft.aufirst=I&rft.date=2009-06-16&rft.volume=260&rft.issue=1-3&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2009.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bioavailability; epigallocatechin-3-gallate; Mortality; Polyphenols; green tea; Catechin; Fasting; Toxicity; Drugs; Morbidity DO - http://dx.doi.org/10.1016/j.tox.2009.03.007 ER - TY - JOUR T1 - A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide. AN - 67382979; 19509150 AB - Manganese superoxide dismutase protects against oxidative damage and modulates the efficacy of chemotherapeutic drugs. A functional single-nucleotide polymorphism in codon 16 of SOD2 (rs4880), which encodes manganese superoxide dismutase, results in a substitution of valine by alanine (Val16Ala). We hypothesized that this single-nucleotide polymorphism affects breast cancer survival of patients receiving chemotherapy. Two patient populations from the United States (n = 248) and Norway (n = 340) were genotyped for Val16Ala. Kaplan-Meier survival and Cox proportional hazards regression analyses were used to examine the relationship between Val16Ala and disease-specific survival. Val16Ala was significantly associated with breast cancer outcome in both patient populations. Carriers of the Ala allele had inferior survival rates in the multivariate analysis [hazard ratio (HR), 2.44 and 95% confidence interval (95% CI), 1.11-5.37 in U.S. cohort; HR, 1.91 and 95% CI, 1.06-3.45 in Norway cohort for Ala/Ala versus Val/Val]. In an analysis of the combined cohorts, this association was significant for patients receiving adjuvant therapy (HR, 2.47; 95% CI, 1.46-4.19), but not for patients without it (HR, 1.47; 95% CI, 0.57-3.74). After further stratification by type of chemotherapy, the effect of the Ala allele was mostly restricted to cyclophosphamide-containing chemotherapy regimens (HR, 22.0; 95% CI, 5.22-92.9; Ala/Ala versus Val/Val). The Val16Ala polymorphism affects survival of patients receiving cyclophosphamide-containing chemotherapy. The findings provide the first evidence pointing toward a mechanism for cyclophosphamide resistance in breast cancer patients. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Glynn, Sharon A AU - Boersma, Brenda J AU - Howe, Tiffany M AU - Edvardsen, Hege AU - Geisler, Stephanie B AU - Goodman, Julie E AU - Ridnour, Lisa A AU - Lønning, Per E AU - Børresen-Dale, Anne-Lise AU - Naume, Bjorn AU - Kristensen, Vessela N AU - Chanock, Stephen J AU - Wink, David A AU - Ambs, Stefan AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, Office of Preventive Oncology, National Cancer Institute, NIH, Bethesda, Maryland 20892-4258, USA. Y1 - 2009/06/15/ PY - 2009 DA - 2009 Jun 15 SP - 4165 EP - 4173 VL - 15 IS - 12 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - superoxide dismutase 2 KW - Index Medicus KW - United States KW - Regression Analysis KW - Polymorphism, Single Nucleotide KW - Humans KW - Aged KW - Multivariate Analysis KW - Genotype KW - Kaplan-Meier Estimate KW - Alleles KW - Survival Rate KW - Adult KW - Cohort Studies KW - Mitochondria -- metabolism KW - Middle Aged KW - Norway KW - Female KW - Proportional Hazards Models KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- mortality KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - Cyclophosphamide -- therapeutic use KW - Drug Resistance, Neoplasm -- genetics KW - Superoxide Dismutase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67382979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+mitochondrial+target+sequence+polymorphism+in+manganese+superoxide+dismutase+predicts+inferior+survival+in+breast+cancer+patients+treated+with+cyclophosphamide.&rft.au=Glynn%2C+Sharon+A%3BBoersma%2C+Brenda+J%3BHowe%2C+Tiffany+M%3BEdvardsen%2C+Hege%3BGeisler%2C+Stephanie+B%3BGoodman%2C+Julie+E%3BRidnour%2C+Lisa+A%3BL%C3%B8nning%2C+Per+E%3BB%C3%B8rresen-Dale%2C+Anne-Lise%3BNaume%2C+Bjorn%3BKristensen%2C+Vessela+N%3BChanock%2C+Stephen+J%3BWink%2C+David+A%3BAmbs%2C+Stefan&rft.aulast=Glynn&rft.aufirst=Sharon&rft.date=2009-06-15&rft.volume=15&rft.issue=12&rft.spage=4165&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-0119 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-01 N1 - Date created - 2009-06-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Causes Control. 2006 Oct;17(8):1025-31 [16933053] J Natl Cancer Inst. 2006 Jul 5;98(13):911-9 [16818855] BMC Cancer. 2006;6:257 [17069650] J Pharm Sci. 2007 Sep;96(9):2181-96 [17593552] Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1581-6 [17646272] Ann Oncol. 2007 Aug;18(8):1293-306 [17317675] Brain Res. 2007 Oct 24;1176:71-81 [17889838] Breast Cancer Res Treat. 2008 Mar;108(2):203-15 [17473980] J Clin Oncol. 2008 Jun 1;26(16):2659-65 [18509177] Breast Cancer Res Treat. 2008 Sep;111(1):93-101 [17922231] Cell Biochem Funct. 2008 Oct;26(7):771-7 [18646267] Carcinogenesis. 2008 Dec;29(12):2335-40 [18784358] Cancer Res. 1979 Apr;39(4):1141-9 [217531] Science. 1985 Jan 25;227(4685):375-81 [2981433] Anal Biochem. 1989 May 15;179(1):8-18 [2547324] Toxicol Lett. 1991 Sep;58(1):69-75 [1716793] Mol Carcinog. 1992;6(4):238-42 [1485915] Chemotherapy. 1994 Jan-Feb;40(1):8-15 [8306820] Nat Med. 1996 Jul;2(7):811-4 [8673929] Biochem Biophys Res Commun. 1996 Sep 13;226(2):561-5 [8806673] J Pathol. 1997 Feb;181(2):140-5 [9120716] Cancer Lett. 2000 Oct 16;159(1):95-101 [10974411] Cancer Res. 2001 Mar 15;61(6):2505-12 [11289122] Carcinogenesis. 2001 May;22(5):827-9 [11323405] Arch Biochem Biophys. 2001 May 1;389(1):84-93 [11370676] Breast Cancer Res. 2001;3(5):323-7 [11597322] Int J Cancer. 2001 Nov15;94(4):545-50 [11745442] Cancer. 2002 Jun 1;94(11):2844-54 [12115371] Br J Haematol. 2003 Feb;120(3):457-63 [12580960] Pharmacogenetics. 2003 Mar;13(3):145-57 [12618592] Nat Rev Cancer. 2003 Apr;3(4):276-85 [12671666] Cancer Causes Control. 2003 Aug;14(6):513-8 [12948282] J Clin Oncol. 2003 Sep 15;21(18):3469-78 [12972522] Clin Cancer Res. 2003 Nov 15;9(15):5582-8 [14654539] Clin Cancer Res. 2003 Nov 15;9(15):5768-75 [14654562] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D528-32 [14681474] Cancer Res. 2004 Apr 1;64(7):2350-6 [15059885] Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):989-96 [15184255] Breast Cancer Res. 2004;6(4):R264-74 [15217492] Cancer Res. 1999 Feb 1;59(3):602-6 [9973207] Jpn J Cancer Res. 1999 May;90(5):555-64 [10391096] Breast Cancer Res. 2004;6(6):R647-55 [15535847] Cancer Res. 2005 Feb 1;65(3):1105-11 [15705913] Biomed Pharmacother. 2005 May;59(4):143-8 [15862707] Pharmacogenet Genomics. 2005 May;15(5):311-9 [15864132] Hum Exp Toxicol. 2005 Jun;24(6):313-8 [16004198] Oncogene. 2005 Dec 8;24(55):8154-66 [16170370] Pharmacogenet Genomics. 2006 Apr;16(4):279-86 [16538174] JAMA. 2006 Jun 7;295(21):2492-502 [16757721] Langenbecks Arch Surg. 2006 Sep;391(5):499-510 [16909291] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-0119 ER - TY - JOUR T1 - Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern China. AN - 67133945; 19296536 AB - To understand the role of environmental and genetic influences on nasopharyngeal carcinoma (NPC) in populations at high risk of NPC, we have performed a case-control study in Guangxi Province of Southern China in 2004-2005. NPC cases (n = 1,049) were compared with 785 NPC-free matched controls who were seropositive for IgA antibodies (IgA) to Epstein-Barr virus (EBV) capsid antigen (VCA)-a predictive marker for NPC in Chinese populations. A questionnaire was used to capture exposure and NPC family history data. Risk factors associated with NPC in a multivariant analysis model were the following: (i) a first, second or third degree relative with NPC [attributable risk (AR)= 6%, odds ratio (OR) = 3.1, 95% confidence interval (CI) = 2.0-4.9, p 0.05). We also assessed the contribution of EBV/IgA/VCA antibody serostatus to NPC risk-32.2% of NPC can be explained by IgA+ status. However, family history and environmental risk factors cumulatively explained only 2.7% of NPC development in NPC high risk population. These findings should have important public health implications for NPC risk reduction in endemic regions. Copyright 2008 UICC. JF - International journal of cancer AU - Guo, Xiuchan AU - Johnson, Randall C AU - Deng, Hong AU - Liao, Jian AU - Guan, Li AU - Nelson, George W AU - Tang, Mingzhong AU - Zheng, Yuming AU - de The, Guy AU - O'Brien, Stephen J AU - Winkler, Cheryl A AU - Zeng, Yi AD - Laboratory of Genomic Diversity, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2009/06/15/ PY - 2009 DA - 2009 Jun 15 SP - 2942 EP - 2947 VL - 124 IS - 12 KW - Antibodies, Viral KW - 0 KW - Antigens, Viral KW - Capsid Proteins KW - Epstein-Barr viral capsid antigen KW - Immunoglobulin A KW - Index Medicus KW - Occupational Exposure KW - Young Adult KW - Capsid Proteins -- immunology KW - Humans KW - Aged KW - Child KW - Antibodies, Viral -- blood KW - Smoking KW - Aged, 80 and over KW - Risk Factors KW - Antigens, Viral -- immunology KW - China -- epidemiology KW - Adult KW - Cohort Studies KW - Surveys and Questionnaires KW - Case-Control Studies KW - Immunoglobulin A -- analysis KW - Middle Aged KW - Diet KW - Adolescent KW - Herpesvirus 4, Human -- immunology KW - Male KW - Female KW - Epstein-Barr Virus Infections -- epidemiology KW - Nasopharyngeal Neoplasms -- epidemiology KW - Nasopharyngeal Neoplasms -- immunology KW - Epstein-Barr Virus Infections -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67133945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Evaluation+of+nonviral+risk+factors+for+nasopharyngeal+carcinoma+in+a+high-risk+population+of+Southern+China.&rft.au=Guo%2C+Xiuchan%3BJohnson%2C+Randall+C%3BDeng%2C+Hong%3BLiao%2C+Jian%3BGuan%2C+Li%3BNelson%2C+George+W%3BTang%2C+Mingzhong%3BZheng%2C+Yuming%3Bde+The%2C+Guy%3BO%27Brien%2C+Stephen+J%3BWinkler%2C+Cheryl+A%3BZeng%2C+Yi&rft.aulast=Guo&rft.aufirst=Xiuchan&rft.date=2009-06-15&rft.volume=124&rft.issue=12&rft.spage=2942&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.24293 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-22 N1 - Date created - 2009-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.24293 ER - TY - CPAPER T1 - Regulatory and Epigenetic Landscapes of Genomes: Fundamental Concepts and In Silico Analysis Methods T2 - Fourth Annual Ohio Collaborative Conference on Bioinformatics (OCCBIO 2009) AN - 42124841; 5140890 JF - Fourth Annual Ohio Collaborative Conference on Bioinformatics (OCCBIO 2009) AU - Elnitski, Laura AU - Welch, Lonnie AU - Drews, Frank AU - Lee, Stephen Y1 - 2009/06/15/ PY - 2009 DA - 2009 Jun 15 KW - Landscape KW - Genomes KW - Epigenetics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42124841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Annual+Ohio+Collaborative+Conference+on+Bioinformatics+%28OCCBIO+2009%29&rft.atitle=Regulatory+and+Epigenetic+Landscapes+of+Genomes%3A+Fundamental+Concepts+and+In+Silico+Analysis+Methods&rft.au=Elnitski%2C+Laura%3BWelch%2C+Lonnie%3BDrews%2C+Frank%3BLee%2C+Stephen&rft.aulast=Elnitski&rft.aufirst=Laura&rft.date=2009-06-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Annual+Ohio+Collaborative+Conference+on+Bioinformatics+%28OCCBIO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.occbio.org/2009/schedule.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - "Transporter dynamics in a bacterial 'glutamate' transporter" T2 - 2009 Gordon Research Conference on Mechanisms Of Membrane Transport AN - 42139838; 5153813 JF - 2009 Gordon Research Conference on Mechanisms Of Membrane Transport AU - Mindell, Joseph Y1 - 2009/06/14/ PY - 2009 DA - 2009 Jun 14 KW - Glutamic acid transporter KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42139838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Mechanisms+Of+Membrane+Transport&rft.atitle=%22Transporter+dynamics+in+a+bacterial+%27glutamate%27+transporter%22&rft.au=Mindell%2C+Joseph&rft.aulast=Mindell&rft.aufirst=Joseph&rft.date=2009-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Mechanisms+Of+Membrane+Transport&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=mechmemb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - C/EBPdelta is a mammary tumor suppressor promoting DNA damage and hypoxia response T2 - 2009 Gordon Research Conference on Mammary Gland Biology AN - 42139759; 5153795 JF - 2009 Gordon Research Conference on Mammary Gland Biology AU - Sterneck, Esta Y1 - 2009/06/14/ PY - 2009 DA - 2009 Jun 14 KW - Hypoxia KW - Tumors KW - Mammary gland KW - DNA damage KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42139759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Mammary+Gland+Biology&rft.atitle=C%2FEBPdelta+is+a+mammary+tumor+suppressor+promoting+DNA+damage+and+hypoxia+response&rft.au=Sterneck%2C+Esta&rft.aulast=Sterneck&rft.aufirst=Esta&rft.date=2009-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Mammary+Gland+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=mammgland LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Asymmetric cell division through selective chromatid segregation as a general mechanism for cellular differentiation T2 - 2009 Gordon Research Conference on Mammary Gland Biology AN - 42139725; 5153784 JF - 2009 Gordon Research Conference on Mammary Gland Biology AU - Klar, Amar Y1 - 2009/06/14/ PY - 2009 DA - 2009 Jun 14 KW - Chromatids KW - Cell division KW - Differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42139725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Mammary+Gland+Biology&rft.atitle=Asymmetric+cell+division+through+selective+chromatid+segregation+as+a+general+mechanism+for+cellular+differentiation&rft.au=Klar%2C+Amar&rft.aulast=Klar&rft.aufirst=Amar&rft.date=2009-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Mammary+Gland+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=mammgland LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A functional role for host ER-parasitophorous vacuole interaction in cross-presentation of Toxoplasma gondii-derived antigens T2 - 2009 Gordon Research Conference on Antigen Cross-Presentation AN - 42139263; 5153675 JF - 2009 Gordon Research Conference on Antigen Cross-Presentation AU - Goldszmid, Romina Y1 - 2009/06/14/ PY - 2009 DA - 2009 Jun 14 KW - Vacuoles KW - Antigen presentation KW - Antigens KW - Toxoplasma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42139263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Antigen+Cross-Presentation&rft.atitle=A+functional+role+for+host+ER-parasitophorous+vacuole+interaction+in+cross-presentation+of+Toxoplasma+gondii-derived+antigens&rft.au=Goldszmid%2C+Romina&rft.aulast=Goldszmid&rft.aufirst=Romina&rft.date=2009-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Antigen+Cross-Presentation&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=antigen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prolactin in breast development and cancer: a journey T2 - 2009 Gordon Research Conference on Mammary Gland Biology AN - 42132401; 5153807 JF - 2009 Gordon Research Conference on Mammary Gland Biology AU - Vonderhaar, Barbara Y1 - 2009/06/14/ PY - 2009 DA - 2009 Jun 14 KW - Breast cancer KW - Prolactin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42132401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Mammary+Gland+Biology&rft.atitle=Prolactin+in+breast+development+and+cancer%3A+a+journey&rft.au=Vonderhaar%2C+Barbara&rft.aulast=Vonderhaar&rft.aufirst=Barbara&rft.date=2009-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Mammary+Gland+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=mammgland LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploiting genomic analyses for pre-clinical testing in mouse models of mammary cancer T2 - 2009 Gordon Research Conference on Mammary Gland Biology AN - 42130030; 5153792 JF - 2009 Gordon Research Conference on Mammary Gland Biology AU - Green, Jeffrey Y1 - 2009/06/14/ PY - 2009 DA - 2009 Jun 14 KW - Cancer KW - Animal models KW - Genomic analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42130030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Mammary+Gland+Biology&rft.atitle=Exploiting+genomic+analyses+for+pre-clinical+testing+in+mouse+models+of+mammary+cancer&rft.au=Green%2C+Jeffrey&rft.aulast=Green&rft.aufirst=Jeffrey&rft.date=2009-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Mammary+Gland+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=mammgland LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - "Na+ access kinetics to the Na/K ATPase" T2 - 2009 Gordon Research Conference on Mechanisms Of Membrane Transport AN - 42129110; 5153823 JF - 2009 Gordon Research Conference on Mechanisms Of Membrane Transport AU - Holmgren, Miguel Y1 - 2009/06/14/ PY - 2009 DA - 2009 Jun 14 KW - Kinetics KW - Na@u+/K@u+-exchanging ATPase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42129110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Mechanisms+Of+Membrane+Transport&rft.atitle=%22Na%2B+access+kinetics+to+the+Na%2FK+ATPase%22&rft.au=Holmgren%2C+Miguel&rft.aulast=Holmgren&rft.aufirst=Miguel&rft.date=2009-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Mechanisms+Of+Membrane+Transport&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=mechmemb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. AN - 67371007; 19524515 AB - The pathways leading from aberrant Prion protein (PrP) metabolism to neurodegeneration are poorly understood. Some familial PrP mutants generate increased (Ctm)PrP, a transmembrane isoform associated with disease. In other disease situations, a potentially toxic cytosolic form (termed cyPrP) might be produced. However, the mechanisms by which (Ctm)PrP or cyPrP cause selective neuronal dysfunction are unknown. Here, we show that both (Ctm)PrP and cyPrP can interact with and disrupt the function of Mahogunin (Mgrn), a cytosolic ubiquitin ligase whose loss causes spongiform neurodegeneration. Cultured cells and transgenic mice expressing either (Ctm)PrP-producing mutants or cyPrP partially phenocopy Mgrn depletion, displaying aberrant lysosomal morphology and loss of Mgrn in selected brain regions. These effects were rescued by either Mgrn overexpression, competition for PrP-binding sites, or prevention of cytosolic PrP exposure. Thus, transient or partial exposure of PrP to the cytosol leads to inappropriate Mgrn sequestration that contributes to neuronal dysfunction and disease. JF - Cell AU - Chakrabarti, Oishee AU - Hegde, Ramanujan S AD - Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA. Y1 - 2009/06/12/ PY - 2009 DA - 2009 Jun 12 SP - 1136 EP - 1147 VL - 137 IS - 6 KW - PrPC Proteins KW - 0 KW - Protein Isoforms KW - MGRN1 protein, human KW - EC 2.3.2.27 KW - Mgrn1 protein, mouse KW - Ubiquitin-Protein Ligases KW - Index Medicus KW - Animals KW - HeLa Cells KW - Protein Isoforms -- metabolism KW - Humans KW - Mice KW - PrPC Proteins -- metabolism KW - Neurodegenerative Diseases -- metabolism KW - Ubiquitin-Protein Ligases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67371007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Functional+depletion+of+mahogunin+by+cytosolically+exposed+prion+protein+contributes+to+neurodegeneration.&rft.au=Chakrabarti%2C+Oishee%3BHegde%2C+Ramanujan+S&rft.aulast=Chakrabarti&rft.aufirst=Oishee&rft.date=2009-06-12&rft.volume=137&rft.issue=6&rft.spage=1136&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=1097-4172&rft_id=info:doi/10.1016%2Fj.cell.2009.03.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-13 N1 - Date created - 2009-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2003 Jul;77(13):7611-22 [12805461] Science. 2003 Jan 31;299(5607):710-2 [12560552] J Biol Chem. 2004 Feb 13;279(7):5435-43 [14645231] J Infect Dis. 1988 Dec;158(6):1198-208 [2904472] Neurology. 1991 May;41(5):681-4 [1674116] Protein Sci. 1992 Oct;1(10):1343-52 [1363897] Brain Pathol. 1995 Jan;5(1):53-9 [7767491] Nature. 1996 Jan 25;379(6563):339-43 [8552188] Neurology. 1996 Feb;46(2):532-7 [8614527] Science. 1998 Feb 6;279(5352):827-34 [9452375] J Biol Chem. 1999 Aug 13;274(33):23396-404 [10438517] EMBO J. 2004 Nov 24;23(23):4550-9 [15526034] Mol Biol Cell. 2005 Jan;16(1):279-91 [15496459] Science. 2005 Jun 3;308(5727):1435-9 [15933194] Curr Mol Med. 2006 Feb;6(1):37-43 [16472111] Nat Methods. 2006 Mar;3(3):205-10 [16489338] J Biol Chem. 2006 Oct 13;281(41):30431-8 [16908519] Cell. 2006 Dec 1;127(5):999-1013 [17129784] Nature. 2007 Jan 11;445(7124):168-76 [17151600] Mol Biol Cell. 2007 Apr;18(4):1129-42 [17229889] Mol Cell. 2007 Apr 27;26(2):175-88 [17466621] Nat Rev Mol Cell Biol. 2007 Jul;8(7):552-61 [17585315] Curr Opin Cell Biol. 2007 Aug;19(4):459-65 [17689064] Science. 2007 Nov 9;318(5852):930-6 [17991853] BMC Biochem. 2007;8 Suppl 1:S3 [18047740] Curr Opin Cell Biol. 2008 Feb;20(1):4-11 [18222686] Dev Cell. 2008 Sep;15(3):359-70 [18804434] Trends Biochem Sci. 2009 Jun;34(6):287-95 [19447626] Science. 2003 Oct 31;302(5646):871-4 [14593181] Nature. 1999 Dec 16;402(6763):822-6 [10617204] Neuron. 2000 Aug;27(2):399-408 [10985358] EMBO J. 2001 Oct 1;20(19):5383-91 [11574470] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14955-60 [11742063] Mol Biol Cell. 2002 Nov;13(11):3775-86 [12429823] Science. 2002 Nov 29;298(5599):1781-5 [12386337] Comment In: Cell. 2009 Jun 12;137(6):994-6 [19524502] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cell.2009.03.042 ER - TY - JOUR T1 - Bacillus anthracis lethal toxin represses MMTV promoter activity through transcription factors. AN - 67308603; 19389405 AB - We have recently shown that the anthrax lethal toxin (LeTx) selectively represses nuclear hormone receptors. In this study, we found that LeTx repressed the activation of the mouse mammary tumor virus promoter related to overexpression of the transcription factors hepatocyte nuclear factor 3, octamer-binding protein 1, and c-Jun. LeTx transcriptional repression was associated with a decrease in the protein levels of these transcription factors in a lethal factor protease activity-dependent manner. Early administration of LeTx antagonists partially or completely abolished the repressive effects of LeTx. In contrast to the rapid cleavage of mitogen-activated protein kinase kinases by LeTx, the degradation of these transcription factors occurred at a relatively late stage after LeTx treatment. In addition, LeTx repressed phorbol-12-myristate-13-acetate-induced mouse mammary tumor virus promoter activity and phorbol 12-myristate 13-acetate induction of endogenous c-Jun protein. Collectively, these findings suggest that transcription factors are intracellular targets of LeTx and expand our understanding of the molecular action of LeTx at a later stage of low-dose exposure. JF - Journal of molecular biology AU - Kang, Zhigang AU - Webster Marketon, Jeanette I AU - Johnson, Antoinette AU - Sternberg, Esther M AD - Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N13 (MSC 9401), Bethesda, MD 20892-9401, USA. Y1 - 2009/06/12/ PY - 2009 DA - 2009 Jun 12 SP - 595 EP - 605 VL - 389 IS - 3 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Transcription Factor AP-1 KW - Transcription Factors KW - anthrax toxin KW - phorbolol myristate acetate KW - 56937-68-9 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Transcription Factor AP-1 -- antagonists & inhibitors KW - Promoter Regions, Genetic -- drug effects KW - COS Cells KW - Transcription Factor AP-1 -- metabolism KW - Tetradecanoylphorbol Acetate -- analogs & derivatives KW - Cercopithecus aethiops KW - Genes, Reporter KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Transcriptional Activation KW - Mammary Tumor Virus, Mouse -- genetics KW - Bacterial Toxins -- metabolism KW - Antigens, Bacterial -- metabolism KW - Transcription Factors -- antagonists & inhibitors KW - Transcription Factors -- metabolism KW - Bacillus anthracis -- metabolism KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67308603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Bacillus+anthracis+lethal+toxin+represses+MMTV+promoter+activity+through+transcription+factors.&rft.au=Kang%2C+Zhigang%3BWebster+Marketon%2C+Jeanette+I%3BJohnson%2C+Antoinette%3BSternberg%2C+Esther+M&rft.aulast=Kang&rft.aufirst=Zhigang&rft.date=2009-06-12&rft.volume=389&rft.issue=3&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=1089-8638&rft_id=info:doi/10.1016%2Fj.jmb.2009.04.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-08 N1 - Date created - 2009-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1991 Dec;11(12):5825-31 [1944265] Science. 1992 Mar 20;255(5051):1573-6 [1347958] Mol Cell Biol. 1995 Oct;15(10):5346-54 [7565684] Am J Physiol. 1996 May;270(5 Pt 2):F806-11 [8928842] Cell Mol Neurobiol. 1996 Apr;16(2):85-101 [8743962] Mol Endocrinol. 1996 Jul;10(7):794-800 [8813720] Curr Opin Cell Biol. 1997 Apr;9(2):240-6 [9069263] Science. 1998 May 1;280(5364):734-7 [9563949] Mol Cell Biol. 1998 Jun;18(6):3416-30 [9584182] Semin Immunol. 1998 Apr;10(2):155-63 [9618761] Mol Endocrinol. 1998 Oct;12(10):1487-98 [9773973] Genes Dev. 1999 Feb 15;13(4):495-504 [10049364] Lab Invest. 1999 Feb;79(2):83-94 [10068197] J Immunol. 1999 Mar 15;162(6):3527-33 [10092810] Mol Endocrinol. 1999 Apr;13(4):604-18 [10194766] Dev Biol. 1999 May 1;209(1):1-10 [10208738] Endocr Rev. 1999 Jun;20(3):321-44 [10368774] J Biol Chem. 2004 Nov 26;279(48):49857-67 [15381691] Infect Immun. 2005 Mar;73(3):1879-85 [15731093] Biochem Biophys Res Commun. 1993 Dec 30;197(3):1260-6 [8280142] Mol Microbiol. 1994 Sep;13(6):1093-100 [7854123] Eur J Immunol. 1995 May;25(5):1431-5 [7774647] Biochem Pharmacol. 1995 Aug 8;50(4):435-42 [7646547] Biochem Biophys Res Commun. 2008 Sep 19;374(2):288-93 [18625197] FEBS Lett. 1999 Nov 26;462(1-2):199-204 [10580119] Matrix Biol. 2000 May;19(2):91-6 [10842092] Biochem J. 2000 Dec 15;352 Pt 3:739-45 [11104681] Int J Med Microbiol. 2000 Oct;290(4-5):421-7 [11111921] Trends Endocrinol Metab. 2000 Sep;11(7):281-5 [10920385] Oncogene. 2001 Feb 8;20(6):669-76 [11314000] Histol Histopathol. 2001 Apr;16(2):595-601 [11332715] Oncogene. 2001 Apr 30;20(19):2465-75 [11402341] Annu Rev Microbiol. 2001;55:647-71 [11544370] Crit Rev Microbiol. 2001;27(3):167-200 [11596878] J Biol Chem. 2001 Oct 26;276(43):39885-91 [11518712] Emerg Infect Dis. 2001 Nov-Dec;7(6):933-44 [11747719] Infect Immun. 2002 Feb;70(2):544-60 [11796581] Ann Rheum Dis. 2002 Nov;61 Suppl 2:ii40-2 [12379619] Clin Exp Immunol. 2003 Feb;131(2):217-24 [12562380] Exp Cell Res. 2005 Apr 1;304(2):593-603 [15748903] Anal Biochem. 2005 Jun 1;341(1):33-9 [15866525] Infect Immun. 2005 Jul;73(7):4238-44 [15972515] Mol Cell Endocrinol. 2005 Sep 28;241(1-2):21-31 [15964137] Cell Microbiol. 2006 Jan;8(1):130-8 [16367872] Microb Pathog. 2006 Oct-Nov;41(4-5):157-67 [16950595] Carcinogenesis. 2007 May;28(5):1104-10 [17114644] Annu Rev Biochem. 2007;76:243-65 [17335404] Infect Immun. 2007 Nov;75(11):5443-52 [17709410] Infect Immun. 2008 Apr;76(4):1410-22 [18227166] Methods Enzymol. 2008;438:355-65 [18413261] J Immunol. 2008 Jun 1;180(11):7516-24 [18490752] Trends Microbiol. 2002 Jun;10(6):287-93 [12088665] Infect Immun. 1992 Jul;60(7):2581-7 [1612727] Mol Cell Biol. 1992 Jul;12(7):3247-61 [1535687] Cell. 1992 Nov 13;71(4):577-86 [1423615] J Virol. 1993 Jan;67(1):415-24 [8380087] Science. 1993 Feb 19;259(5098):1132-3 [8382375] Mol Endocrinol. 1993 Apr;7(4):570-84 [8388998] J Biol Chem. 2003 Mar 14;278(11):9402-6 [12522135] Doc Ophthalmol. 2003 Jan;106(1):25-9 [12675482] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5706-11 [12724519] Cesk Fysiol. 2003 Aug;52(3):118-28 [12931542] Annu Rev Cell Dev Biol. 2003;19:45-70 [14570563] Cell. 2003 Dec 12;115(6):751-63 [14675539] Nat Struct Mol Biol. 2004 Jan;11(1):60-6 [14718924] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):30-45 [15020043] Mol Cell Biol. 2004 Apr;24(7):3036-47 [15024090] Curr Opin Microbiol. 2004 Feb;7(1):19-24 [15036135] J Endocrinol. 2004 May;181(2):207-21 [15128270] Biochem Biophys Res Commun. 2004 Aug 27;321(3):601-5 [15358148] EMBO J. 1982;1(12):1613-9 [6327283] Infect Immun. 1986 Mar;51(3):795-800 [3081444] Infect Immun. 1986 May;52(2):356-63 [3084381] Nature. 1988 Aug 18;334(6183):629-31 [2457172] J Exp Med. 1989 Feb 1;169(2):431-45 [2783450] Proc Natl Acad Sci U S A. 1989 Apr;86(7):2374-8 [2538840] Proc Natl Acad Sci U S A. 1990 May;87(10):3977-81 [2160080] J Virol. 1990 Sep;64(9):4477-88 [2166825] Biochem Biophys Res Commun. 1990 Oct 15;172(1):348-56 [2171522] Cell. 1991 Feb 8;64(3):565-72 [1846780] Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2274-7 [1900940] FASEB J. 1991 Apr;5(7):2044-51 [2010057] Mol Cell Biol. 1991 May;11(5):2529-37 [1708094] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jmb.2009.04.030 ER - TY - CPAPER T1 - Mycobacterial Susceptibility: The Real (Bob) Goods T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 42112062; 5134830 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Holland, Steven Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Diseases KW - Mycobacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42112062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=Mycobacterial+Susceptibility%3A+The+Real+%28Bob%29+Goods&rft.au=Holland%2C+Steven&rft.aulast=Holland&rft.aufirst=Steven&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Expression of Latency Associated Peptide (LAP) and IL-1 Receptor Type I/II (CD121a/CD121b) on Activated human FOXP3+ Regulatory T Cells Allows for Their Purification from Expansion Cultures for Potential Immunotherapy T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 42096967; 5134994 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Tran, Dat AU - Shevach, Ethan Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Immunotherapy KW - Interleukin 1 receptors KW - Cell culture KW - Protein purification KW - Lymphocytes T KW - Immunoregulation KW - Foxp3 protein KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42096967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=Selective+Expression+of+Latency+Associated+Peptide+%28LAP%29+and+IL-1+Receptor+Type+I%2FII+%28CD121a%2FCD121b%29+on+Activated+human+FOXP3%2B+Regulatory+T+Cells+Allows+for+Their+Purification+from+Expansion+Cultures+for+Potential+Immunotherapy&rft.au=Tran%2C+Dat%3BShevach%2C+Ethan&rft.aulast=Tran&rft.aufirst=Dat&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Eosinophilic Esophagitis and Atopic Dermatitis Treated with Omalizumab in a Patient with NEMO Defect T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 42095516; 5135170 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Heimall, Jennifer AU - Fessler, Margaret AU - Jain, Ashish Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Dermatitis KW - Monoclonal antibodies KW - Atopic dermatitis KW - Esophagitis KW - Leukocytes (eosinophilic) KW - Immunoglobulin E KW - Defects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42095516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=Eosinophilic+Esophagitis+and+Atopic+Dermatitis+Treated+with+Omalizumab+in+a+Patient+with+NEMO+Defect&rft.au=Heimall%2C+Jennifer%3BFessler%2C+Margaret%3BJain%2C+Ashish&rft.aulast=Heimall&rft.aufirst=Jennifer&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genotype-phenotype Correlations in STAT3 Mutated hyper IgE Syndrome (hIES) Patients T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 42092168; 5135048 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Heimall, Jennifer AU - Freeman, Alexandra AU - Davis, Joie AU - Hsu, Amy AU - Shaw, Pamela AU - Holland, Steven Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Stat3 protein KW - Job's syndrome KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42092168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=Genotype-phenotype+Correlations+in+STAT3+Mutated+hyper+IgE+Syndrome+%28hIES%29+Patients&rft.au=Heimall%2C+Jennifer%3BFreeman%2C+Alexandra%3BDavis%2C+Joie%3BHsu%2C+Amy%3BShaw%2C+Pamela%3BHolland%2C+Steven&rft.aulast=Heimall&rft.aufirst=Jennifer&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor Antigen-speci\c CD8 T Cells In\ltrating the Tumor Express high Levels of PD-1 and are Functionally Impaired T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 42091212; 5134863 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Ahmadzadeh, Mojgan AU - Johnson, Laura AU - Heemskerk, Bianca AU - Wunderlich, John AU - Rosenberg, Steven Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Tumors KW - CD8 antigen KW - Lymphocytes T KW - PD-1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42091212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=Tumor+Antigen-speci%5Cc+CD8+T+Cells+In%5Cltrating+the+Tumor+Express+high+Levels+of+PD-1+and+are+Functionally+Impaired&rft.au=Ahmadzadeh%2C+Mojgan%3BJohnson%2C+Laura%3BHeemskerk%2C+Bianca%3BWunderlich%2C+John%3BRosenberg%2C+Steven&rft.aulast=Ahmadzadeh&rft.aufirst=Mojgan&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute Exposure to IL-4 Reveals a Novel Pathway for Induction of hemophagocytosis and histiocytosis T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 42090117; 5134848 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Milner, Joshua AU - Lily, Cheng AU - Ward, Jerrold AU - Finkelman, Fred AU - Paul, William AU - Orekov, Tatyana Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Histiocytosis KW - Interleukin 4 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42090117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=Acute+Exposure+to+IL-4+Reveals+a+Novel+Pathway+for+Induction+of+hemophagocytosis+and+histiocytosis&rft.au=Milner%2C+Joshua%3BLily%2C+Cheng%3BWard%2C+Jerrold%3BFinkelman%2C+Fred%3BPaul%2C+William%3BOrekov%2C+Tatyana&rft.aulast=Milner&rft.aufirst=Joshua&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Th2 Responses T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 42089871; 5134788 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Wynn, Tom Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Lymphocytes T KW - Helper cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42089871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=Regulation+of+Th2+Responses&rft.au=Wynn%2C+Tom&rft.aulast=Wynn&rft.aufirst=Tom&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SAP Augments Proximal T Cell Receptor Signal Strength Necessary for Restimulation-induced Apoptosis of Activated T Cells T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 42089703; 5135230 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Snow, Andrew AU - Marsh, Rebecca AU - Krummey, Scott AU - Roehrs, Philip AU - Zhang, Kejian AU - Filipovich, Lisa AU - Su, Helen AU - Bleesing, Jacob AU - Lenardo, Michael Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - T-cell receptor KW - Apoptosis KW - Lymphocytes T KW - SAP protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42089703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=SAP+Augments+Proximal+T+Cell+Receptor+Signal+Strength+Necessary+for+Restimulation-induced+Apoptosis+of+Activated+T+Cells&rft.au=Snow%2C+Andrew%3BMarsh%2C+Rebecca%3BKrummey%2C+Scott%3BRoehrs%2C+Philip%3BZhang%2C+Kejian%3BFilipovich%2C+Lisa%3BSu%2C+Helen%3BBleesing%2C+Jacob%3BLenardo%2C+Michael&rft.aulast=Snow&rft.aufirst=Andrew&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GARP (LRRC32) is Essential for the Surface Expression of Latent TGFbeta on Platelets and Activated FOXP3+ Regulatory T Cells by Anchoring it to the Membrane T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 42086853; 5134868 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Tran, Dat AU - Shevach, Ethan Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Membranes KW - Platelets KW - Lymphocytes T KW - Immunoregulation KW - Foxp3 protein KW - Anchoring KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42086853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=GARP+%28LRRC32%29+is+Essential+for+the+Surface+Expression+of+Latent+TGFbeta+on+Platelets+and+Activated+FOXP3%2B+Regulatory+T+Cells+by+Anchoring+it+to+the+Membrane&rft.au=Tran%2C+Dat%3BShevach%2C+Ethan&rft.aulast=Tran&rft.aufirst=Dat&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Regulation of Lymphocyte homeostasis T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 42085911; 5134779 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Lenardo, Mike Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Lymphocytes KW - Homeostasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42085911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=Molecular+Regulation+of+Lymphocyte+homeostasis&rft.au=Lenardo%2C+Mike&rft.aulast=Lenardo&rft.aufirst=Mike&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identifying Biomarkers in ALPS: SerumVitamin B12 and Plasma IL-10 Levels as Potential Diagnostic Tools T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 40192404; 5175856 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Oliveira, Joao Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Bioindicators KW - Interleukin 10 KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40192404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=Identifying+Biomarkers+in+ALPS%3A+SerumVitamin+B12+and+Plasma+IL-10+Levels+as+Potential+Diagnostic+Tools&rft.au=Oliveira%2C+Joao&rft.aulast=Oliveira&rft.aufirst=Joao&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SomaticMosaicism for STAT3Mutation Unveils Critical Role in Human T CellMemory Development and B Cell Help T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 40186277; 5175858 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Milner, Joshua Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Lymphocytes B KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40186277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=SomaticMosaicism+for+STAT3Mutation+Unveils+Critical+Role+in+Human+T+CellMemory+Development+and+B+Cell+Help&rft.au=Milner%2C+Joshua&rft.aulast=Milner&rft.aufirst=Joshua&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence and Functional Significance of Anti-Cytokine Autoantibodies in Thymoma T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 40172933; 5175864 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Browne, Sarah Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Thymoma KW - Autoantibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40172933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=Prevalence+and+Functional+Significance+of+Anti-Cytokine+Autoantibodies+in+Thymoma&rft.au=Browne%2C+Sarah&rft.aulast=Browne&rft.aufirst=Sarah&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a Corneal/Lens-Specific miRNA Gene, miR-184 T2 - 2009 Keystone Symposia on MicroRNA and Cancer (E1) AN - 42136319; 5156404 JF - 2009 Keystone Symposia on MicroRNA and Cancer (E1) AU - Li, Yan Y1 - 2009/06/10/ PY - 2009 DA - 2009 Jun 10 KW - MiRNA KW - Cornea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42136319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+MicroRNA+and+Cancer+%28E1%29&rft.atitle=Characterization+of+a+Corneal%2FLens-Specific+miRNA+Gene%2C+miR-184&rft.au=Li%2C+Yan&rft.aulast=Li&rft.aufirst=Yan&rft.date=2009-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+MicroRNA+and+Cancer+%28E1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 19 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MicroRNAs and Inflammatory Cytokines as Biomarkers of Cancer Diagnosis, Prognosis, and Therapeutic Outcome T2 - 2009 Keystone Symposia on MicroRNA and Cancer (E1) AN - 42135475; 5156410 JF - 2009 Keystone Symposia on MicroRNA and Cancer (E1) AU - Harris, Curtis Y1 - 2009/06/10/ PY - 2009 DA - 2009 Jun 10 KW - Cancer KW - Bioindicators KW - Cytokines KW - MiRNA KW - Inflammation KW - Biomarkers KW - Prognosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42135475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+MicroRNA+and+Cancer+%28E1%29&rft.atitle=MicroRNAs+and+Inflammatory+Cytokines+as+Biomarkers+of+Cancer+Diagnosis%2C+Prognosis%2C+and+Therapeutic+Outcome&rft.au=Harris%2C+Curtis&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2009-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+MicroRNA+and+Cancer+%28E1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 19 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cholera toxin inhibits IL-12 production and CD8I- super(+) dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function AN - 21447949; 11866984 AB - Prior studies have demonstrated that cholera toxin (CT) and other cAMP-inducing factors inhibit interleukin (IL)-12 production from monocytes and dendritic cells (DCs). We show that CT inhibits Th1 responses in vivo in mice infected with Toxoplasma gondii. This correlated with low serum IL-12 levels and a selective reduction in the numbers of CD8I- super(+) conventional DCs (cDCs) in lymphoid organs. CT inhibited the function of interferon (IFN) regulatory factor (IRF) 8, a transcription factor known to positively regulate IL-12p35 and p40 gene expression, and the differentiation of CD8I- super(+) and plasmacytoid DCs (pDCs). Fluorescence recovery after photobleaching analysis showed that exposure to CT, forskolin, or dibutyryl (db) cAMP blocked LPS and IFN-I3ainduced IRF8 binding to chromatin. Moreover, CT and dbcAMP inhibited the binding of IRF8 to the IFN-stimulated response element (ISRE)alike element in the mouse IL-12p40 promoter, likely by blocking the formation of ISRE-binding IRF1aIRF8 heterocomplexes. Furthermore, CT inhibited the differentiation of pDCs from fms-like tyrosine kinase 3 ligandatreated bone marrow cells in vitro. Therefore, because IRF8 is essential for IL-12 production and the differentiation of CD8I- super(+) cDCs and pDCs, these data suggest that CT and other Gs-protein agonists can affect IL-12 production and DC differentiation via a common mechanism involving IRF8. JF - Journal of Experimental Medicine AU - la Sala, Andrea AU - He, Jianping AU - Laricchia-Robbio, Leopoldo AU - Gorini, Stefania AU - Iwasaki, Akiko AU - Braun, Michael AU - Yap, George S AU - Sher, Alan AU - Ozato, Keiko AU - Kelsall, Brian AD - Mucosal Immunobiology Section, Laboratory of Molecular Immunology , 3 Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease , 4 Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 Y1 - 2009/06/08/ PY - 2009 DA - 2009 Jun 08 SP - 1227 EP - 1235 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA VL - 206 IS - 6 SN - 0022-1007, 0022-1007 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Chromatin KW - Toxicants KW - Helper cells KW - Bone marrow KW - Fluorescence recovery after photobleaching KW - Public health KW - Gene expression KW - Promoters KW - Differentiation KW - Dendritic cells KW - Interleukin 12 KW - Cholera toxin KW - Lymphocytes T KW - Lipopolysaccharides KW - Monocytes KW - Data processing KW - Pathogenic bacteria KW - Regulatory sequences KW - Cyclic AMP KW - Bacterial diseases KW - p40 gene KW - Interferon KW - Serum KW - Toxoplasma gondii KW - Transcription factors KW - Flt3 protein KW - Cell differentiation KW - Forskolin KW - Q1 08206:Physiology, biochemistry, biophysics KW - X 24370:Natural Toxins KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21447949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Cholera+toxin+inhibits+IL-12+production+and+CD8I-+super%28%2B%29+dendritic+cell+differentiation+by+cAMP-mediated+inhibition+of+IRF8+function&rft.au=la+Sala%2C+Andrea%3BHe%2C+Jianping%3BLaricchia-Robbio%2C+Leopoldo%3BGorini%2C+Stefania%3BIwasaki%2C+Akiko%3BBraun%2C+Michael%3BYap%2C+George+S%3BSher%2C+Alan%3BOzato%2C+Keiko%3BKelsall%2C+Brian&rft.aulast=la+Sala&rft.aufirst=Andrea&rft.date=2009-06-08&rft.volume=206&rft.issue=6&rft.spage=1227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/10.1084%2Fjem.20080912 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Gene expression; Pathogenic bacteria; Toxicants; Serum; Bacterial diseases; Cell differentiation; Public health; Data processing; Chromatin; Regulatory sequences; Helper cells; Cyclic AMP; Bone marrow; p40 gene; Fluorescence recovery after photobleaching; Interleukin 12; Dendritic cells; Differentiation; Promoters; Interferon; Cholera toxin; Flt3 protein; Transcription factors; Lymphocytes T; Lipopolysaccharides; Monocytes; Forskolin; Toxoplasma gondii DO - http://dx.doi.org/10.1084/jem.20080912 ER - TY - CPAPER T1 - Adult Stem Cells and Nanomaterials in Cartilage Tissue Engineering and Regeneration T2 - 2009 Gordon Research Conference on Cartilage Biology and Pathology AN - 42140680; 5156714 JF - 2009 Gordon Research Conference on Cartilage Biology and Pathology AU - Tuan, Rocky Y1 - 2009/06/07/ PY - 2009 DA - 2009 Jun 07 KW - Stem cells KW - Nanotechnology KW - Regeneration KW - Tissue engineering KW - Cartilage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42140680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Cartilage+Biology+and+Pathology&rft.atitle=Adult+Stem+Cells+and+Nanomaterials+in+Cartilage+Tissue+Engineering+and+Regeneration&rft.au=Tuan%2C+Rocky&rft.aulast=Tuan&rft.aufirst=Rocky&rft.date=2009-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Cartilage+Biology+and+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=cartilage LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissecting the Regulation of Limb Skeletal Patterning and Morphogenesis with Conditional Genetic Approaches T2 - 2009 Gordon Research Conference on Cartilage Biology and Pathology AN - 42140613; 5156693 JF - 2009 Gordon Research Conference on Cartilage Biology and Pathology AU - Mackem, Susan Y1 - 2009/06/07/ PY - 2009 DA - 2009 Jun 07 KW - Limbs KW - Morphogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42140613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Cartilage+Biology+and+Pathology&rft.atitle=Dissecting+the+Regulation+of+Limb+Skeletal+Patterning+and+Morphogenesis+with+Conditional+Genetic+Approaches&rft.au=Mackem%2C+Susan&rft.aulast=Mackem&rft.aufirst=Susan&rft.date=2009-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Cartilage+Biology+and+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=cartilage LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Therapy with Parathyroid Hormone-related Protein Protects Chondrocytes from Cyclic Tensile Strain-induced Injury T2 - 2009 Gordon Research Conference on Cartilage Biology and Pathology AN - 42138868; 5156705 JF - 2009 Gordon Research Conference on Cartilage Biology and Pathology AU - Wang, Dean Y1 - 2009/06/07/ PY - 2009 DA - 2009 Jun 07 KW - Injuries KW - Parathyroid hormone-related protein KW - Gene therapy KW - Chondrocytes KW - Thyroid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42138868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Cartilage+Biology+and+Pathology&rft.atitle=Gene+Therapy+with+Parathyroid+Hormone-related+Protein+Protects+Chondrocytes+from+Cyclic+Tensile+Strain-induced+Injury&rft.au=Wang%2C+Dean&rft.aulast=Wang&rft.aufirst=Dean&rft.date=2009-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Cartilage+Biology+and+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=cartilage LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell biology and regulation of store-operated calcium entry T2 - 2009 Gordon Research Conference on Phosphorylation and G-Protein Mediated Signaling Networks AN - 42136738; 5156511 JF - 2009 Gordon Research Conference on Phosphorylation and G-Protein Mediated Signaling Networks AU - Putne, James Y1 - 2009/06/07/ PY - 2009 DA - 2009 Jun 07 KW - Calcium KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42136738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Phosphorylation+and+G-Protein+Mediated+Signaling+Networks&rft.atitle=Cell+biology+and+regulation+of+store-operated+calcium+entry&rft.au=Putne%2C+James&rft.aulast=Putne&rft.aufirst=James&rft.date=2009-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Phosphorylation+and+G-Protein+Mediated+Signaling+Networks&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=phosphor LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Complex Interactions between Matriptase and the Kunitz-Type Inhibitors, Hai-1 and Hai-2 Enable Embryonic Development and Postnatal Epithelial Homeostasis T2 - Proteases in Hemostasis and Vascular Biology AN - 42131579; 5152731 JF - Proteases in Hemostasis and Vascular Biology AU - Bugge, Thomas Y1 - 2009/06/07/ PY - 2009 DA - 2009 Jun 07 KW - Embryogenesis KW - Homeostasis KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42131579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Proteases+in+Hemostasis+and+Vascular+Biology&rft.atitle=Complex+Interactions+between+Matriptase+and+the+Kunitz-Type+Inhibitors%2C+Hai-1+and+Hai-2+Enable+Embryonic+Development+and+Postnatal+Epithelial+Homeostasis&rft.au=Bugge%2C+Thomas&rft.aulast=Bugge&rft.aufirst=Thomas&rft.date=2009-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Proteases+in+Hemostasis+and+Vascular+Biology&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11650.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dendritic signal processing in CA1 pyramidal neurons of the hippocampus T2 - Ion Channel Regulation AN - 42129175; 5152808 JF - Ion Channel Regulation AU - Hoffman, Dax Y1 - 2009/06/07/ PY - 2009 DA - 2009 Jun 07 KW - Pyramidal cells KW - Data processing KW - Hippocampus KW - Signal processing KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42129175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Ion+Channel+Regulation&rft.atitle=Dendritic+signal+processing+in+CA1+pyramidal+neurons+of+the+hippocampus&rft.au=Hoffman%2C+Dax&rft.aulast=Hoffman&rft.aufirst=Dax&rft.date=2009-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Ion+Channel+Regulation&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11700.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - From Retrotranslocation to Cancer Therapy: the Anti- Cancer Activity of a Retrotranslocation Inhibitor T2 - From Unfolded Proteins in the Endoplasmic Reticulum to Disease AN - 42128067; 5152791 JF - From Unfolded Proteins in the Endoplasmic Reticulum to Disease AU - Ye, Yihong Y1 - 2009/06/07/ PY - 2009 DA - 2009 Jun 07 KW - Cancer KW - Therapy KW - Inhibitors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42128067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=From+Unfolded+Proteins+in+the+Endoplasmic+Reticulum+to+Disease&rft.atitle=From+Retrotranslocation+to+Cancer+Therapy%3A+the+Anti-+Cancer+Activity+of+a+Retrotranslocation+Inhibitor&rft.au=Ye%2C+Yihong&rft.aulast=Ye&rft.aufirst=Yihong&rft.date=2009-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=From+Unfolded+Proteins+in+the+Endoplasmic+Reticulum+to+Disease&rft.issn=&rft_id=info:doi/ L2 - https://secure.faseb.org/faseb/meetings/Summrconf/Programs/11591.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity. AN - 67311534; 19324872 AB - p38 MAPKs are typically activated by upstream MAPK kinases that phosphorylate a Thr-X-Tyr motif in the activation loop. An exception is the T cell antigen receptor signaling pathway, which bypasses the MAPK cascade and activates p38alpha and p38beta by phosphorylation of Tyr-323 and subsequent autophosphorylation of the activation loop. Here we show that, unlike the classic MAPK cascade, the alternative pathway results primarily in mono-phosphorylation of the activation loop residue Thr-180. Recombinant mono-phosphorylated and dual phosphorylated p38alpha differed widely with regard to activity and substrate preference. Altered substrate specificity was reproduced in T cells in which p38 was activated by the alternative or classical MAPK pathways. These findings suggest that T cells have evolved a mechanism to utilize p38 in a specialized manner independent of and distinct from the classical p38 MAPK signaling cascade. JF - The Journal of biological chemistry AU - Mittelstadt, Paul R AU - Yamaguchi, Hiroshi AU - Appella, Ettore AU - Ashwell, Jonathan D AD - Laboratory of Immune Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/06/05/ PY - 2009 DA - 2009 Jun 05 SP - 15469 EP - 15474 VL - 284 IS - 23 SN - 0021-9258, 0021-9258 KW - Receptors, Antigen, T-Cell KW - 0 KW - Recombinant Proteins KW - Threonine KW - 2ZD004190S KW - Tyrosine KW - 42HK56048U KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Threonine -- metabolism KW - Enzyme Activation KW - Humans KW - Mice KW - T-Lymphocytes -- enzymology KW - Phosphorylation KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Adenosine Triphosphate -- metabolism KW - Mice, Inbred C57BL KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Tyrosine -- metabolism KW - Recombinant Proteins -- chemistry KW - Substrate Specificity KW - Signal Transduction KW - p38 Mitogen-Activated Protein Kinases -- genetics KW - p38 Mitogen-Activated Protein Kinases -- chemistry KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Receptors, Antigen, T-Cell -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67311534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=T+cell+receptor-mediated+activation+of+p38%7Balpha%7D+by+mono-phosphorylation+of+the+activation+loop+results+in+altered+substrate+specificity.&rft.au=Mittelstadt%2C+Paul+R%3BYamaguchi%2C+Hiroshi%3BAppella%2C+Ettore%3BAshwell%2C+Jonathan+D&rft.aulast=Mittelstadt&rft.aufirst=Paul&rft.date=2009-06-05&rft.volume=284&rft.issue=23&rft.spage=15469&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M901004200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-13 N1 - Date created - 2009-06-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Semin Cancer Biol. 2004 Aug;14(4):271-82 [15219620] Biochemistry. 2009 Mar 24;48(11):2497-504 [19209848] J Biol Chem. 1985 Mar 25;260(6):3344-9 [3972829] J Biol Chem. 1995 Mar 31;270(13):7420-6 [7535770] Biochem Biophys Res Commun. 1996 Nov 12;228(2):334-40 [8920915] J Biol Chem. 1996 Dec 13;271(50):31964-72 [8943243] Cell. 1997 Sep 5;90(5):859-69 [9298898] J Immunol. 1997 Dec 1;159(11):5309-17 [9548470] Mol Cell Biol. 1999 Jan;19(1):21-30 [9858528] J Immunol. 1999 Apr 1;162(7):4246-52 [10201954] Mol Cell Biol. 1999 Jun;19(6):4289-301 [10330170] Structure. 1999 Sep 15;7(9):1057-65 [10508788] J Biol Chem. 2004 Nov 5;279(45):47040-9 [15284239] Nat Immunol. 2005 Apr;6(4):390-5 [15735648] J Biol Chem. 2000 Jan 7;275(1):197-209 [10617605] Mol Cell Biol. 2000 Feb;20(3):936-46 [10629051] J Biol Chem. 2000 Apr 28;275(17):12560-4 [10777545] Immunopharmacology. 2000 May;47(2-3):185-201 [10878289] Free Radic Biol Med. 2000 May 1;28(9):1328-37 [10924852] Blood. 2000 Sep 1;96(5):1844-52 [10961885] J Biol Chem. 2001 Feb 23;276(8):5676-84 [11069918] Nat Immunol. 2001 Feb;2(2):157-64 [11175814] Physiol Rev. 2001 Apr;81(2):807-69 [11274345] Endocr Rev. 2001 Apr;22(2):153-83 [11294822] Leukemia. 2001 Jun;15(6):869-74 [11417471] J Biol Chem. 2001 Jul 6;276(27):25351-8 [11309396] J Biol Chem. 2002 Apr 19;277(16):13889-99 [11839761] Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12281-6 [12213961] Annu Rev Biochem. 2003;72:249-89 [12626339] Nat Immunol. 2004 Jan;5(1):38-44 [14691480] Int Immunol. 2004 Feb;16(2):295-302 [14734615] Microbiol Mol Biol Rev. 2004 Jun;68(2):320-44 [15187187] Nat Immunol. 2005 Apr;6(4):396-402 [15735649] Nat Immunol. 2005 Apr;6(4):368-70 [15785766] Mol Cell Biol. 2006 Mar;26(6):2118-29 [16507991] J Immunol. 2006 Apr 15;176(8):4616-21 [16585552] J Biol Chem. 2006 Jul 28;281(30):21353-61 [16714293] J Mol Biol. 2007 Jan 5;365(1):66-76 [17059827] Nat Immunol. 2007 Feb;8(2):154-61 [17187070] J Mol Biol. 2008 Jun 20;379(5):1075-93 [18501927] J Biol Chem. 2008 Sep 26;283(39):26591-601 [18669639] Biochemistry. 2004 Aug 10;43(31):9950-60 [15287722] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M901004200 ER - TY - JOUR T1 - The origin and global emergence of adamantane resistant A/H3N2 influenza viruses AN - 20604987; 9311290 AB - Resistance to the adamantane class of antiviral drugs by human A/H3N2 influenza viruses currently exceeds 90% in the United States and multiple Asian countries. Adamantane resistance is associated with a single amino acid change (S31N) in the M2 protein, which was shown to rapidly disseminate globally in 2005 in association with a genome reassortment event. However, the exact origin of influenza A /H3N2 viruses carrying the S31N mutation has not been characterized, particularly in South-East Asia. We therefore conducted a phylogenetic analysis of the HA, NA, and M1/2 segments of viral isolates collected between 1997 and 2007 from temperate localities in the Northern hemisphere (New York State, United States, 492 isolates) and Southern hemisphere (New Zealand and Australia, 629 isolates) and a subtropical locality in South-East Asia (Hong Kong, 281 isolates). We find that although the S31N mutation was independently introduced at least 11 times, the vast majority of resistant viruses now circulating globally descend from a single introduction that was first detected in the summer of 2003 in Hong Kong. These resistant viruses were continually detected in Hong Kong throughout 2003-2005, acquired a novel HA through reassortment during the first part of 2005, and thereafter spread globally. The emergence and persistence of adamantane resistant viruses in Hong Kong further supports a source-sink model of global influenza virus ecology, in which South-East Asia experiences continuous viral activity and repeatedly seeds epidemics in temperate areas. JF - Virology AU - Nelson, MI AU - Simonsen, L AU - Viboud, C AU - Miller, MA AU - Holmes, E C AD - National Institutes of Health, Bethesda, MD 20892, USA, nelsonma@mail.nih.gov Y1 - 2009/06/05/ PY - 2009 DA - 2009 Jun 05 SP - 270 EP - 278 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 388 IS - 2 SN - 0042-6822, 0042-6822 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Genomes KW - Phylogeny KW - Seeds KW - Influenza virus KW - Amino acids KW - Epidemics KW - Antiviral agents KW - Influenza A KW - Mutation KW - Models KW - A 01340:Antibiotics & Antimicrobials KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20604987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=The+origin+and+global+emergence+of+adamantane+resistant+A%2FH3N2+influenza+viruses&rft.au=Nelson%2C+MI%3BSimonsen%2C+L%3BViboud%2C+C%3BMiller%2C+MA%3BHolmes%2C+E+C&rft.aulast=Nelson&rft.aufirst=MI&rft.date=2009-06-05&rft.volume=388&rft.issue=2&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2009.03.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phylogeny; Genomes; Seeds; Epidemics; Amino acids; Antiviral agents; Influenza A; Mutation; Models; Influenza virus DO - http://dx.doi.org/10.1016/j.virol.2009.03.026 ER - TY - JOUR T1 - Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. AN - 67275656; 19272840 AB - Maintenance of the mitochondrial genome (mtDNA) is essential for proper cellular function. The accumulation of damage and mutations in the mtDNA leads to diseases, cancer, and aging. Mammalian mitochondria have proficient base excision repair, but the existence of other DNA repair pathways is still unclear. Deficiencies in DNA mismatch repair (MMR), which corrects base mismatches and small loops, are associated with DNA microsatellite instability, accumulation of mutations, and cancer. MMR proteins have been identified in yeast and coral mitochondria; however, MMR proteins and function have not yet been detected in human mitochondria. Here we show that human mitochondria have a robust mismatch-repair activity, which is distinct from nuclear MMR. Key nuclear MMR factors were not detected in mitochondria, and similar mismatch-binding activity was observed in mitochondrial extracts from cells lacking MSH2, suggesting distinctive pathways for nuclear and mitochondrial MMR. We identified the repair factor YB-1 as a key candidate for a mitochondrial mismatch-binding protein. This protein localizes to mitochondria in human cells, and contributes significantly to the mismatch-binding and mismatch-repair activity detected in HeLa mitochondrial extracts, which are significantly decreased when the intracellular levels of YB-1 are diminished. Moreover, YB-1 depletion in cells increases mitochondrial DNA mutagenesis. Our results show that human mitochondria contain a functional MMR repair pathway in which YB-1 participates, likely in the mismatch-binding and recognition steps. JF - DNA repair AU - de Souza-Pinto, Nadja C AU - Mason, Penelope A AU - Hashiguchi, Kazunari AU - Weissman, Lior AU - Tian, Jingyan AU - Guay, David AU - Lebel, Michel AU - Stevnsner, Tinna V AU - Rasmussen, Lene Juel AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, National Institute on Aging/Intramural Research Program (NIA-IRP), National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2009/06/04/ PY - 2009 DA - 2009 Jun 04 SP - 704 EP - 719 VL - 8 IS - 6 SN - 1568-7864, 1568-7864 KW - DNA, Mitochondrial KW - 0 KW - DNA-Binding Proteins KW - Nuclear Proteins KW - Y-Box-Binding Protein 1 KW - YBX1 protein, human KW - Index Medicus KW - Oxygen Consumption KW - HeLa Cells KW - Cell Nucleus -- metabolism KW - Humans KW - Electrophoretic Mobility Shift Assay KW - Subcellular Fractions KW - Chloramphenicol Resistance KW - Nuclear Proteins -- genetics KW - DNA Mismatch Repair KW - DNA-Binding Proteins -- genetics KW - Mitochondria -- metabolism KW - Nuclear Proteins -- metabolism KW - DNA-Binding Proteins -- metabolism KW - DNA, Mitochondrial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67275656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Novel+DNA+mismatch-repair+activity+involving+YB-1+in+human+mitochondria.&rft.au=de+Souza-Pinto%2C+Nadja+C%3BMason%2C+Penelope+A%3BHashiguchi%2C+Kazunari%3BWeissman%2C+Lior%3BTian%2C+Jingyan%3BGuay%2C+David%3BLebel%2C+Michel%3BStevnsner%2C+Tinna+V%3BRasmussen%2C+Lene+Juel%3BBohr%2C+Vilhelm+A&rft.aulast=de+Souza-Pinto&rft.aufirst=Nadja&rft.date=2009-06-04&rft.volume=8&rft.issue=6&rft.spage=704&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2009.01.021 LA - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.dnarep.2009.01.021 ER - TY - JOUR T1 - Temporal changes in the T1 and T2 relaxation rates ( Delta *DR1 and Delta *DR2) in the rat brain are consistent with the tissue-clearance rates of elemental manganese AN - 883039607; 15255421 AB - Temporal changes in the T1 and T2 relaxation rates ( Delta *DR1 and Delta *DR2) in rat olfactory bulb (OB) and cortex were compared with the absolute manganese (Mn) concentrations from the corresponding excised tissue samples. In vivo T1 and T2 relaxation times were measured before, and at 1, 7, 28, and 35 d after intravenous infusion of 176 mg/kg MnCl2. The values of Delta *DR1, Delta *DR2, and absolute Mn concentration peaked at day 1 and then declined to near control levels after 28 to 35 d. The Mn bioelimination rate from the rat brain was significantly faster than that reported using radioisotope techniques. The R1 and R2 relaxation rates were linearly proportional to the underlying tissue Mn concentration and reflect the total absolute amount of Mn present in the tissue. The in vivo Mn r1 and r2 tissue relaxivities were comparable to the in vitro values for aqueous Mn2+. These results demonstrate that loss of manganese-enhanced MRI (MEMRI) contrast after systemic Mn2+ administration is due to elimination of Mn2+ from the brain. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Chuang, Kai-Hsiang AU - Koretsky, Alan P AU - Sotak, Christopher H AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA, csotak@wpi.edu Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 1528 EP - 1532 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 61 IS - 6 SN - 1522-2594, 1522-2594 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain KW - Cortex KW - Cortex (olfactory) KW - Cortex (temporal) KW - Intravenous administration KW - Magnetic resonance imaging KW - Manganese KW - N.M.R. KW - Olfactory bulb KW - Radioisotopes KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883039607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Temporal+changes+in+the+T1+and+T2+relaxation+rates+%28+Delta+*DR1+and+Delta+*DR2%29+in+the+rat+brain+are+consistent+with+the+tissue-clearance+rates+of+elemental+manganese&rft.au=Chuang%2C+Kai-Hsiang%3BKoretsky%2C+Alan+P%3BSotak%2C+Christopher+H&rft.aulast=Chuang&rft.aufirst=Kai-Hsiang&rft.date=2009-06-01&rft.volume=61&rft.issue=6&rft.spage=1528&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.21962 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.21962/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Cortex (olfactory); Intravenous administration; Cortex; Magnetic resonance imaging; Radioisotopes; Brain; Cortex (temporal); N.M.R.; Manganese; Olfactory bulb DO - http://dx.doi.org/10.1002/mrm.21962 ER - TY - JOUR T1 - HTGRAPPA: Real-time B1-weighted image domain TGRAPPA reconstruction AN - 883039545; 15255409 AB - The temporal generalized autocalibrating partially parallel acquisitions (TGRAPPA) algorithm for parallel MRI was modified for real-time low latency imaging in interventional procedures using image domain, B1-weighted reconstruction. GRAPPA coefficients were calculated in k-space, but applied in the image domain after appropriate transformation. Convolution-like operations in k-space were thus avoided, resulting in improved reconstruction speed. Image domain GRAPPA weights were combined into composite unmixing coefficients using adaptive B1-map estimates and optimal noise weighting. Images were reconstructed by pixel-by-pixel multiplication in the image domain, rather than time-consuming convolution operations in k-space. Reconstruction and weight-set calculation computations were parallelized and implemented on a general-purpose multicore architecture. The weight calculation was performed asynchronously to the real-time image reconstruction using a dedicated parallel processing thread. The weight-set coefficients were computed in an adaptive manner with updates linked to changes in the imaging scan plane. In this implementation, reconstruction speed is not dependent on acceleration rate or GRAPPA kernel size. Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Saybasili, Haris AU - Kellman, Peter AU - Griswold, Mark A AU - Derbyshire, J Andrew AU - Guttman, Michael A AD - National Institutes of Health, National Heart, Lung, and Blood Institute, DHHS, Bethesda, Maryland, saybasilih@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 1425 EP - 1433 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 61 IS - 6 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Transformation KW - Magnetic resonance imaging KW - Algorithms KW - Image processing KW - Kernels KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883039545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=HTGRAPPA%3A+Real-time+B1-weighted+image+domain+TGRAPPA+reconstruction&rft.au=Saybasili%2C+Haris%3BKellman%2C+Peter%3BGriswold%2C+Mark+A%3BDerbyshire%2C+J+Andrew%3BGuttman%2C+Michael+A&rft.aulast=Saybasili&rft.aufirst=Haris&rft.date=2009-06-01&rft.volume=61&rft.issue=6&rft.spage=1425&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.21922 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.21922/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transformation; Magnetic resonance imaging; Algorithms; Kernels; Image processing; N.M.R. DO - http://dx.doi.org/10.1002/mrm.21922 ER - TY - JOUR T1 - Long-term transduction of miniature pig parotid glands using serotype 2 adeno-associated viral vectors AN - 883025253; 15246543 AB - Background Previously, using an adenoviral vector, we showed that miniature pigs could provide a valuable and affordable large animal model for pre-clinical gene therapy studies to correct parotid gland radiation damage. However, adenoviral vectors lead to short-term transgene expression and, ideally, a more stable correction is required. In the present study, we examined the suitability of using a serotype 2 adeno-associated viral (AAV2) vector to mediate more stable gene transfer in the parotid glands of these animals. Methods Heparan sulfate proteoglycan was detected by immunohistochemistry. beta -galactosidase expression was determined histochemically. An AAV2 vector encoding human erythropoietin (hEpo) was administered via Stensen's duct. Salivary and serum hEpo levels were measured using an enzyme-linked immunosorbent assay. Serum chemistry and hematological analyses were performed and serum antibodies to hEpo were measured throughout the study. Vector distribution was determined by a quantitative polymerase chain reaction. Results Transgene expression was vector dose-dependent, with high levels of hEpo being detected for up to 32 weeks (i.e. the longest time studied). hEpo reached maximal levels during weeks 4-8, but declined to approximately 25% of these values by week 32. Haematocrits were elevated from week 2. Transduced animals exhibited low serum anti-hEpo antibodies (1 : 8-1 : 16). Vector biodistribution at animal sacrifice revealed that most copies were in the targeted parotid gland, with few being detected elsewhere. No consistent adverse changes in serum chemistry or hematology parameters were seen. Conclusions AAV2 vectors mediate extended gene transfer to miniature pig parotid glands and should be useful for testing pre-clinical gene therapy strategies aiming to correct salivary gland radiation damage. JF - Journal of Gene Medicine AU - Hai, Bo AU - Yan, Xing AU - Voutetakis, Antonis AU - Zheng, Changyu AU - Cotrim, Ana P AU - Shan, Zhaochen AU - Ding, Gang AU - Zhang, Chunmei AU - Xu, Junji AU - Goldsmith, Corinne M AU - Afione, Sandra AU - Chiorini, John A AU - Baum, Bruce J AU - Wang, Songlin AD - Salivary Gland Disease Center and the Molecular Laboratory for Gene Therapy, School of Stomatology, Capital Medical University, Beijing, China, bbaum@dir.nidcr.nih.gov bbaum@dir.nidcr.nih.gov bbaum@dir.nidcr.nih.gov bbaum@dir.nidcr.nih.gov bbaum@dir.nidcr.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 506 EP - 514 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 11 IS - 6 SN - 1521-2254, 1521-2254 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Enzyme-linked immunosorbent assay KW - Serotypes KW - beta -Galactosidase KW - Gene therapy KW - Transgenes KW - Parotid gland KW - Animal models KW - Salivary gland KW - Expression vectors KW - Antibodies KW - Erythropoietin KW - Radiation KW - Polymerase chain reaction KW - Immunohistochemistry KW - Heparan sulfate proteoglycans KW - W 30905:Medical Applications KW - V 22410:Animal Diseases KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883025253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gene+Medicine&rft.atitle=Long-term+transduction+of+miniature+pig+parotid+glands+using+serotype+2+adeno-associated+viral+vectors&rft.au=Hai%2C+Bo%3BYan%2C+Xing%3BVoutetakis%2C+Antonis%3BZheng%2C+Changyu%3BCotrim%2C+Ana+P%3BShan%2C+Zhaochen%3BDing%2C+Gang%3BZhang%2C+Chunmei%3BXu%2C+Junji%3BGoldsmith%2C+Corinne+M%3BAfione%2C+Sandra%3BChiorini%2C+John+A%3BBaum%2C+Bruce+J%3BWang%2C+Songlin&rft.aulast=Hai&rft.aufirst=Bo&rft.date=2009-06-01&rft.volume=11&rft.issue=6&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gene+Medicine&rft.issn=15212254&rft_id=info:doi/10.1002%2Fjgm.1319 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jgm.1319/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Serotypes; Gene therapy; beta -Galactosidase; Parotid gland; Transgenes; Animal models; Salivary gland; Expression vectors; Antibodies; Radiation; Erythropoietin; Polymerase chain reaction; Heparan sulfate proteoglycans; Immunohistochemistry DO - http://dx.doi.org/10.1002/jgm.1319 ER - TY - JOUR T1 - Improved shim method based on the minimization of the maximum off-resonance frequency for balanced steady-state free precession (bSSFP) AN - 883019986; 15255417 AB - In this work, a shim method that minimizes the maximum off-resonance frequency (min-max shim) in balanced steady-state free precession (bSSFP) is tested for brain imaging at 3T with constant and linear shim terms. The method demonstrates improvement of spatial coverage and banding artifact reduction over standard least-squares shimming. In addition, a new method (modified min-max shim) is introduced. This method reduces boundary band regions where the artifact is inevitable due to the excessive off-resonance frequency distribution. In comparison to standard least-squares shimming, the min-max based shim method either eliminates or reduces the size of banding artifacts. The method can be used to increase the signal-to-noise ratio (SNR) in bSSFP imaging or to increase the functional contrast in bSSFP functional MRI (fMRI) by allowing a longer usable repetition time (TR). Magn Reson Med, 2009. [copy 2009 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Lee, Jongho AU - Lustig, Michael AU - Kim, Dong-hyun AU - Pauly, John M AD - Advanced MRI, Laboratory for Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, jonghoyi@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 1500 EP - 1506 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 61 IS - 6 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Repetition KW - Brain mapping KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Boundaries KW - N.M.R. KW - Banding KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883019986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Improved+shim+method+based+on+the+minimization+of+the+maximum+off-resonance+frequency+for+balanced+steady-state+free+precession+%28bSSFP%29&rft.au=Lee%2C+Jongho%3BLustig%2C+Michael%3BKim%2C+Dong-hyun%3BPauly%2C+John+M&rft.aulast=Lee&rft.aufirst=Jongho&rft.date=2009-06-01&rft.volume=61&rft.issue=6&rft.spage=1500&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.21800 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.21800/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Brain mapping; Repetition; Neuroimaging; Functional magnetic resonance imaging; Boundaries; N.M.R.; Banding DO - http://dx.doi.org/10.1002/mrm.21800 ER - TY - JOUR T1 - Successful behavioral strategy to unite mother and infant rhesus monkeys (Macaca mulatta) after cesarean delivery AN - 839142371; 4147213 AB - Developmental studies of pre- to postnatal continuities in rhesus monkeys sometimes require infants be reared with their mothers. However, complications during pregnancy or experimental designs may require cesarean delivery. Owing to lack of published information on this subject, strategies are needed to introduce mothers to their infants following cesarean delivery. Using positive and negative reinforcement techniques we attempted to unite six infant rhesus macaques, Macaca mulatta, to their mothers following c-sections. For our seventh subject, we attempted to cross-foster an infant onto an unrelated female after she had undergone a cesarean surgery for a late-term spontaneous abortion. The mothers varied in age, parity, previous postnatal mothering experience with infants, housing earlier to delivery, and housing subsequent to introduction. Although there were large individual differences among the mother-infant pairs, all seven introductions were successful. The mothers learned to accept and care for their infants from the continuous application of operant conditioning techniques. These data suggest that mother-rearing following cesarean section is a realistic possibility whether required for clinical reasons or for proper experimental control. Furthermore, the ability to successfully mother-rear infants produced from cesarean delivery lessens the impact this potential confound of not being reared by their mothers exerts on many types of developmental studies. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Ruggiero, Angela M AU - Novak, Matthew F.S.X. AU - Woodward, Ruth A AU - Suomi, Stephen J AD - National Institutes of Health, Maryland Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 510 EP - 522 VL - 71 IS - 6 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Birth KW - Primatology KW - Mothers KW - Primate behaviour KW - Anthropological analysis KW - Medical treatment KW - Primates KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839142371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Successful+behavioral+strategy+to+unite+mother+and+infant+rhesus+monkeys+%28Macaca+mulatta%29+after+cesarean+delivery&rft.au=Ruggiero%2C+Angela+M%3BNovak%2C+Matthew+F.S.X.%3BWoodward%2C+Ruth+A%3BSuomi%2C+Stephen+J&rft.aulast=Ruggiero&rft.aufirst=Angela&rft.date=2009-06-01&rft.volume=71&rft.issue=6&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20681 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1063 971; 10149; 10148; 10144 10148 10149 1542 11325; 1635 11574; 7890 5792 10484; 8317 9184; 6495 2212 DO - http://dx.doi.org/10.1002/ajp.20681 ER - TY - JOUR T1 - Invited Review: Histology Atlas of the Developing Mouse Heart with Emphasis on E11.5 to E18.5 AN - 746199600; 12621240 AB - In humans, congenital heart diseases are common. Since the rapid progression of transgenic technologies, the mouse has become the major animal model of defective cardiovascular development. Moreover, genetically modified mice frequently die in utero, commonly due to abnormal cardiovascular development. A variety of publications address specific developmental stages or structures of the mouse heart, but a single reference reviewing and describing the anatomy and histology of cardiac developmental events, stage by stage, has not been available. The aim of this color atlas, which demonstrates embryonic/fetal heart development, is to provide a tool for pathologists and biomedical scientists to use for detailed histological evaluation of hematoxylin and eosin (H&E)-stained sections of the developing mouse heart with emphasis on embryonic days (E) 11.5-18.5. The selected images illustrate the main structures and developmental events at each stage and serve as reference material for the confirmation of the chronological age of the embryo/early fetus and assist in the identification of any abnormalities. An extensive review of the literature covering cardiac development pre-E11.5 is summarized in the introduction. Although the focus of this atlas is on the descriptive anatomic and histological development of the normal mouse heart from E11.5 to E18.5, potential embryonic cardiac lesions are discussed with a list of the most common transgenic pre- and perinatal heart defects. Representative images of hearts at E11.5-15.5 and E18.5 are provided in Figures 2-4, 6, 8, and 9. A complete set of labeled images (Figures E11.5-18.5) is available on the CD enclosed in this issue of Toxicologic Pathology. All digital images can be viewed online at https://niehsimages.epl-inc.com with the username ''ToxPath'' and the password ''embryohearts.'' JF - Toxicologic Pathology AU - Savolainen, Saija M AU - Foley, Julie F AU - Elmore, Susan A AD - NIEHS, Cellular and Molecular Pathology Branch, Research Triangle Park, North Carolina, USA, elmore@niehs.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 395 EP - 414 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 37 IS - 4 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Heart KW - Embryogenesis KW - Age KW - Atlases KW - Reviews KW - Animal models KW - Developmental stages KW - Embryos KW - Fetuses KW - Color KW - Heart diseases KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746199600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Invited+Review%3A+Histology+Atlas+of+the+Developing+Mouse+Heart+with+Emphasis+on+E11.5+to+E18.5&rft.au=Savolainen%2C+Saija+M%3BFoley%2C+Julie+F%3BElmore%2C+Susan+A&rft.aulast=Savolainen&rft.aufirst=Saija&rft.date=2009-06-01&rft.volume=37&rft.issue=4&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623309335060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Heart; Age; Embryogenesis; Atlases; Reviews; Animal models; Developmental stages; Embryos; Fetuses; Heart diseases; Color DO - http://dx.doi.org/10.1177/0192623309335060 ER - TY - JOUR T1 - Gene Expression Studies Reveal That DNA Damage, Vascular Perturbation, and Inflammation Contribute to the Pathogenesis of Carbonyl Sulfide Neurotoxicity AN - 746199409; 12621243 AB - Carbonyl sulfide (COS) is an odorless gas that produces highly reproducible lesions in the central nervous system. In the present study, the time course for the development of the neurotoxicological lesions was defined and the gene expression changes occurring in the posterior colliculus upon exposure to COS were characterized. Fischer 344 rats were exposed to 0 or 500 ppm COS for one, two, three, four, five, eight, or ten days, six hours per day. On days 1 and 2, no morphological changes were detected; on day 3, 10/10 (100%) rats had necrosis in the posterior colliculi; and on day 4 and later, necrosis was observed in numerous areas of the brain. Important gene expression changes occurring in the posterior colliculi after one or two days of COS exposure that were predictive of the subsequent morphological findings included up-regulation of genes associated with DNA damage and G1/S checkpoint regulation (KLF4, BTG2, GADD45g), apoptosis (TGM2, GADD45g, RIPK3), and vascular mediators (ADAMTS, CTGF, CYR61, VEGFC). Proinflammatory mediators (CCL2, CEBPD) were up-regulated prior to increases in expression of the astrocytic marker GFAP and macrophage marker CSF2rb1. These gene expression findings were predictive of later CNS lesions caused by COS exposure and serve as a model for future investigations into the mechanisms of disease in the central nervous system. JF - Toxicologic Pathology AU - Morrison, James P AU - Ton, Thai-Vu AU - Collins, Jennifer B AU - Switzer, Robert C AU - Little, Peter B AU - Morgan, Daniel L AU - Sills, Robert C AD - Charles River Laboratories, Pathology Associates, Durham, NC 27703, USA, sills@niehs.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 502 EP - 511 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 37 IS - 4 SN - 0192-6233, 0192-6233 KW - Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Macrophages KW - Central nervous system KW - BTG2 protein KW - Apoptosis KW - Monocyte chemoattractant protein 1 KW - Connective tissue growth factor KW - Colliculus KW - CYR61 protein KW - Glial fibrillary acidic protein KW - Brain KW - KLF4 protein KW - Inflammation KW - Gene expression KW - Sulfide KW - DNA damage KW - Necrosis KW - Neurotoxicity KW - carbonyls KW - Vascular system KW - N 14820:DNA Metabolism & Structure KW - N3 11028:Neuropharmacology & toxicology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746199409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Gene+Expression+Studies+Reveal+That+DNA+Damage%2C+Vascular+Perturbation%2C+and+Inflammation+Contribute+to+the+Pathogenesis+of+Carbonyl+Sulfide+Neurotoxicity&rft.au=Morrison%2C+James+P%3BTon%2C+Thai-Vu%3BCollins%2C+Jennifer+B%3BSwitzer%2C+Robert+C%3BLittle%2C+Peter+B%3BMorgan%2C+Daniel+L%3BSills%2C+Robert+C&rft.aulast=Morrison&rft.aufirst=James&rft.date=2009-06-01&rft.volume=37&rft.issue=4&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623309335631 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 48 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Macrophages; Central nervous system; BTG2 protein; Monocyte chemoattractant protein 1; Apoptosis; CYR61 protein; Colliculus; Connective tissue growth factor; Brain; Glial fibrillary acidic protein; KLF4 protein; Inflammation; Gene expression; DNA damage; Sulfide; Necrosis; Neurotoxicity; carbonyls; Vascular system DO - http://dx.doi.org/10.1177/0192623309335631 ER - TY - JOUR T1 - Multiplex Manager 1.0: a cross-platform computer program that plans and optimizes multiplex PCR AN - 746079848; 13053556 AB - Multiplex Manager 1.0 is a user-friendly cross-platform program that designs efficient combinations of existing genetic marker loci into multiplex polymerase chain reactions and optimizes using prior marker information. The program has the flexibility to solve two design problems: combining all markers into the smallest number of reactions, or alternatively, selecting a subset from many available markers to design an efficient and robust multiplex. Our program minimizes the number of reactions, the genetic linkage, and the difference in annealing temperature. At the same time it maximizes the spacing between markers, the heterozygosity, and the number of alleles. The final output provides easily interpreted and informative graphical representations of reactions, as well as the option of manually editing final reactions. Multiplex Manager 1.0 is freely available at www.multiplexmanager.com. JF - BioTechniques AU - Holleley, CE AU - Geerts, P G AD - Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA, holleleyce@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 511 EP - 519 PB - Eaton Publishing Co., One Research Drive, Suite 400A PO Box 1070 Westboro MA 01581 USA VL - 46 IS - 7 SN - 0736-6205, 0736-6205 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Computer programs KW - Genetic markers KW - Polymerase chain reaction KW - Heterozygosity KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3A&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Internal+Medicine&rft.atitle=Navigating+language+barriers%3A+A+systematic+review+of+patient+navigators%E2%80%99+impact+on+cancer+screening+for+limited+English+proficient+patients&rft.au=Genoff%2C+Margaux+C.%3BZaballa%2C+Alexandra%3BGany%2C+Francesca%3BGonzalez%2C+Javier%3BRamirez%2C+Julia%3BJewell%2C+Sarah+T.%3BDiamond%2C+Lisa+C.&rft.aulast=Genoff&rft.aufirst=Margaux&rft.date=2016-04-01&rft.volume=31&rft.issue=4&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Internal+Medicine&rft.issn=08848734&rft_id=info:doi/10.1007%2Fs11606-015-3572-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Temperature effects; Computer programs; Genetic markers; Polymerase chain reaction; Heterozygosity DO - http://dx.doi.org/10.2144/000113156 ER - TY - JOUR T1 - ClpXP protease degrades the cytoskeletal protein, FtsZ, and modulates FtsZ polymer dynamics AN - 745899422; 10916331 AB - FtsZ is the major cytoskeletal protein in bacteria and a tubulin homologue. It polymerizes and forms a ring where constriction occurs to divide the cell. We found that FtsZ is degraded by E. coli ClpXP, an ATP-dependent protease. In vitro, ClpXP degrades both FtsZ protomers and polymers; however, polymerized FtsZ is degraded more rapidly than the monomer. Deletion analysis shows that the N-terminal domain of ClpX is important for polymer recognition and that the FtsZ C terminus contains a ClpX recognition signal. In vivo, FtsZ is turned over slower in a clpX deletion mutant compared with a WT strain. Overexpression of ClpXP results in increased FtsZ degradation and filamentation of cells. These results suggest that ClpXP may participate in cell division by modulating the equilibrium between free and polymeric FtsZ via degradation of FtsZ filaments and protomers. JF - Proceedings of the National Academy of Sciences, USA AU - Camberg, Jodi L AU - Hoskins, Joel R AU - Wickner, Sue AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, wickners@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 10614 EP - 10619 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 26 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - AAA+ ATPase KW - cell division KW - ClpP KW - proteolysis KW - septum KW - Cytoskeleton KW - Monomers KW - Cell division KW - Deletion mutant KW - Escherichia coli KW - Proteinase KW - Tubulin KW - Filaments KW - Filamentation KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745899422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=ClpXP+protease+degrades+the+cytoskeletal+protein%2C+FtsZ%2C+and+modulates+FtsZ+polymer+dynamics&rft.au=Camberg%2C+Jodi+L%3BHoskins%2C+Joel+R%3BWickner%2C+Sue&rft.aulast=Camberg&rft.aufirst=Jodi&rft.date=2009-06-01&rft.volume=106&rft.issue=26&rft.spage=10614&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0904886106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Monomers; Cytoskeleton; Cell division; Deletion mutant; Proteinase; Tubulin; Filaments; Filamentation; Escherichia coli DO - http://dx.doi.org/10.1073/pnas.0904886106 ER - TY - JOUR T1 - Nanofunctional Materials in Cancer Research: Challenges, Novel Methods, and Emerging Applications AN - 745698631; 12915079 AB - Despite recent progress in the treatment of cancer, far too many cases are still diagnosed only after tumors have metastasized. As a result, patients with cancer face a grim prognosis and often need to endure toxic and uncomfortable whole-body chemotherapy and/or other radiation treatments with the hope that their cancers will be eliminated. If the disease can be detected early enough, statistics have shown that the burden of cancer is drastically reduced. Nanotechnology applied to cancer, by way of nanofunctional materials, is in a unique position to significantly transform the way the disease is diagnosed, imaged, and treated and is the focus of this issue of MRS Bulletin. Materials research in nanotechnology is already successfully implemented in several applications. For instance, photocatalysis using TiO sub(2) nanoparticles is becoming the dominant method for the "self-cleaning" of material surfaces such as glass, ceramics, and fabrics. The nanomaterial carbon nanotubes is a promising candidate in sensor technology and field-emission technology. Our goal is to illustrate the promising new methods being developed in the research community and the challenges that need to be overcome in order to reach clinical utility. More importantly, we hope this issue helps educate and invoke the materials science community to tackle some of the hard issues in diagnosing and treating this disease. JF - M R S Bulletin AU - Nagahara, LA AU - Ferrari, M AU - Grodzinski, P AD - National, Cancer Institute, Bethesda, MD 20892-2580, USA, nagaharl@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 406 EP - 409 VL - 34 IS - 6 SN - 0883-7694, 0883-7694 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Chemotherapy KW - Prognosis KW - Tumors KW - Cancer KW - Ceramics KW - Fabrics KW - Carbon KW - Radiation KW - nanotubes KW - nanoparticles KW - nanotechnology KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745698631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=M+R+S+Bulletin&rft.atitle=Nanofunctional+Materials+in+Cancer+Research%3A+Challenges%2C+Novel+Methods%2C+and+Emerging+Applications&rft.au=Nagahara%2C+LA%3BFerrari%2C+M%3BGrodzinski%2C+P&rft.aulast=Nagahara&rft.aufirst=LA&rft.date=2009-06-01&rft.volume=34&rft.issue=6&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=M+R+S+Bulletin&rft.issn=08837694&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Fabrics; Ceramics; Carbon; Statistics; Radiation; Chemotherapy; Prognosis; nanotubes; Tumors; nanoparticles; Cancer; nanotechnology ER - TY - JOUR T1 - Patulin Surveillance in Apple Cider and Juice Marketed in Michigan AN - 744673898; 12685668 AB - Patulin is the most common mycotoxin found in apples and apple juices. The objective of this study was to determine the concentrations of patulin in (i) apple cider produced and marketed by Michigan apple cider mills during the fall seasons of 2002 to 2003 and 2003 to 2004 and (ii) apple juice and cider, including shelf-stable products, marketed in retail grocery stores in Michigan throughout 2005 and 2006. End product samples (n = 493) obtained from 104 Michigan apple cider mills were analyzed for patulin concentration by using solid-phase extraction followed by high-performance liquid chromatography. Patulin was detected (.4 kg/liter) in 18.7% of all cider mill samples, with 11 samples (2.2%) having patulin concentrations of .50 kg/liter. A greater percentage of cider samples obtained from mills using thermal pasteurization contained detectable patulin (28.4%) than did those from mills using UV light radiation (13.5%) or no pathogen reduction treatment (17.0%). Among retail grocery store samples (n = 159), 23% of apple juice and cider samples contained detectable patulin, with 18 samples (11.3%) having patulin concentrations of .50 kg/liter. The U.S. Food and Drug Administration (FDA) action level for patulin is 50 kg/kg. Some apple juice samples obtained from retail grocery stores had exceptionally high patulin concentrations, ranging up to 2,700 kg/liter. Collectively, these results indicate that most apple cider and juice test samples from Michigan were below the FDA action level for patulin but that certain apple cider and juice processors have inadequate controls over patulin concentrations in final products. The industry, overall, should focus on improved quality of fruit used in juice production and improve culling procedures to reduce patulin concentrations. JF - Journal of Food Protection AU - Harris, Kerri L AU - Bobe, Gerd AU - Bourquin, Leslie D AD - Department of Food Science and Human Nutrition, Michigan State University, 139A GM Trout FSHN Building, East Lansing, Michigan 48824-1224; and 2 Food Safety Policy Center, National Food Safety and Toxicology Center, Michigan State University, 165 Food Safety and Toxicology Building,East Lansing, Michigan 48824-1302, USAMS 08-072: Received 8 February 2008/Accepted 24 January 2009* Author for correspondence. Tel: 517-355-8474, Ext 112; Fax: 517-353-8963; bourquil[AT]msu.edu. Present address: U.S. Department of Agriculture, Food Safety and Inspection Service, Office of Program Evaluation, Enforcement and Review, Evaluation and Enforcement Division, Washington, DC 20250, USA. Present address: Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 1255 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 72 IS - 6 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - High-performance liquid chromatography KW - Fruit juices KW - Fruits KW - Mycotoxins KW - Patulin KW - U.V. radiation KW - Culling KW - Malus KW - Cider KW - Pathogens KW - Pasteurization KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744673898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Patulin+Surveillance+in+Apple+Cider+and+Juice+Marketed+in+Michigan&rft.au=Harris%2C+Kerri+L%3BBobe%2C+Gerd%3BBourquin%2C+Leslie+D&rft.aulast=Harris&rft.aufirst=Kerri&rft.date=2009-06-01&rft.volume=72&rft.issue=6&rft.spage=1255&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 43 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Fruits; Fruit juices; Mycotoxins; U.V. radiation; Patulin; Culling; Cider; Pathogens; Pasteurization; Malus ER - TY - JOUR T1 - Grazing and digestion of magnetotactic bacteria by ciliates AN - 742911319; 2010-049194 JF - Geochimica et Cosmochimica Acta AU - Silveira, T S AU - Martins, J L AU - Abreu, F AU - Silva, K T AU - Aranova, M AU - da Silva-Neto, I D AU - Kachar, B AU - Lins, U AU - Anonymous Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 1 PB - Elsevier, New York, NY VL - 73 IS - 13S SN - 0016-7037, 0016-7037 KW - experimental studies KW - Protista KW - diet KW - living taxa KW - biochemistry KW - prokaryotes KW - magnetosomes KW - TEM data KW - iron KW - geochemical cycle KW - laboratory studies KW - magnetotactic taxa KW - chemical reactions KW - metals KW - greigite KW - bacteria KW - Invertebrata KW - particulate materials KW - sulfides KW - geochemistry KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742911319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Grazing+and+digestion+of+magnetotactic+bacteria+by+ciliates&rft.au=Silveira%2C+T+S%3BMartins%2C+J+L%3BAbreu%2C+F%3BSilva%2C+K+T%3BAranova%2C+M%3Bda+Silva-Neto%2C+I+D%3BKachar%2C+B%3BLins%2C+U%3BAnonymous&rft.aulast=Silveira&rft.aufirst=T&rft.date=2009-06-01&rft.volume=73&rft.issue=13S&rft.spage=A1225&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 19th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 2 N1 - PubXState - NY N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - bacteria; biochemistry; chemical reactions; diet; experimental studies; geochemical cycle; geochemistry; greigite; Invertebrata; iron; laboratory studies; living taxa; magnetosomes; magnetotactic taxa; metals; particulate materials; prokaryotes; Protista; sulfides; TEM data ER - TY - JOUR T1 - Treatment for spasmodic dysphonia: limitations of current approaches. AN - 742785568; pmid-19337127 AB - PURPOSE OF REVIEW: Although botulinum toxin injection is the gold standard for treatment of spasmodic dysphonia, surgical approaches aimed at providing long-term symptom control have been advancing over recent years. RECENT FINDINGS: When surgical approaches provide greater long-term benefits to symptom control, they also increase the initial period of side effects of breathiness and swallowing difficulties. Recent analyses of quality-of-life questionnaires in patients undergoing regular injections of botulinum toxin demonstrate that a large proportion of patients have limited relief for relatively short periods due to early breathiness and loss-of-benefit before reinjection. SUMMARY: Most medical and surgical approaches to the treatment of spasmodic dysphonia have been aimed at denervation of the laryngeal muscles to block symptom expression in the voice, and have both adverse effects as well as treatment benefits. Research is needed to identify the central neuropathophysiology responsible for the laryngeal muscle spasms in order target treatment towards the central neurological abnormality responsible for producing symptoms. JF - Current opinion in otolaryngology & head and neck surgery AU - Ludlow, Christy L AD - Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1416, Bethesda, MD 20892-1416, USA. ludlowc@ninds.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 160 EP - 165 VL - 17 IS - 3 SN - 1068-9508, 1068-9508 KW - Index Medicus KW - National Library of Medicine KW - Dysphonia -- surgery KW - Dysphonia -- etiology KW - Microsurgery -- methods KW - Laryngeal Muscles -- surgery KW - Botulinum Toxin Type A -- therapeutic use KW - Humans KW - Injections, Intramuscular KW - Outcome and Process Assessment (Health Care) KW - Laryngeal Muscles -- drug effects KW - Dysphonia -- diagnosis KW - Recurrent Laryngeal Nerve -- surgery KW - Laryngeal Muscles -- innervation KW - Muscle Denervation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742785568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+otolaryngology+%26+head+and+neck+surgery&rft.atitle=Treatment+for+spasmodic+dysphonia%3A+limitations+of+current+approaches.&rft.au=Ludlow%2C+Christy+L&rft.aulast=Ludlow&rft.aufirst=Christy&rft.date=2009-06-01&rft.volume=17&rft.issue=3&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+otolaryngology+%26+head+and+neck+surgery&rft.issn=10689508&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-06-15 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline. AN - 733223993; 19486508 AB - Virtually all cases of cervical cancer are caused by persistent infections with a restricted set of human papillomaviruses (HPV). Some HPV types, like HPV16 and HPV18, are clear and powerful carcinogens. However, the categorization of the most weakly carcinogenic HPV types is extremely challenging. The decisions are important for screening test and vaccine development. This article describes for open discussion an approach recently taken by a World Health Organization International Agency for Research on Cancer (IARC) Monographs Working Group to re-assess the carcinogenicity of different HPV types. JF - Infectious agents and cancer AU - Schiffman, Mark AU - Clifford, Gary AU - Buonaguro, Franco M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, 20892, USA. schiffmm@mail.nih.gov Y1 - 2009/06/01/ PY - 2009 DA - 2009 Jun 01 SP - 8 VL - 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733223993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infectious+agents+and+cancer&rft.atitle=Classification+of+weakly+carcinogenic+human+papillomavirus+types%3A+addressing+the+limits+of+epidemiology+at+the+borderline.&rft.au=Schiffman%2C+Mark%3BClifford%2C+Gary%3BBuonaguro%2C+Franco+M&rft.aulast=Schiffman&rft.aufirst=Mark&rft.date=2009-06-01&rft.volume=4&rft.issue=&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Infectious+agents+and+cancer&rft.issn=1750-9378&rft_id=info:doi/10.1186%2F1750-9378-4-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-10 N1 - Date created - 2009-06-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet Oncol. 2009 Apr;10(4):321-2 [19350698] Lancet Oncol. 2005 Apr;6(4):204 [15830458] Cancer Detect Prev. 2005;29(1):37-41 [15734215] J Natl Cancer Inst. 2005 Jan 19;97(2):147-50 [15657345] Br J Cancer. 2003 Jul 7;89(1):101-5 [12838308] N Engl J Med. 2009 Apr 2;360(14):1453-5 [19339726] N Engl J Med. 2009 Apr 2;360(14):1385-94 [19339719] Int J Cancer. 2009 Feb 15;124(4):964-9 [19030188] Vaccine. 2008 Aug 19;26 Suppl 10:K42-52 [18847556] Vaccine. 2008 Aug 19;26 Suppl 10:K1-16 [18847553] Int J Cancer. 2008 Apr 1;122(7):1684-5 [18059025] Int J Cancer. 2008 Jan 1;122(1):244-6 [17764116] Br J Dermatol. 2007 Oct;157(4):788-94 [17634082] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] Lancet Infect Dis. 2007 Jul;7(7):453-9 [17597569] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Virus Res. 2007 May;125(2):176-82 [17257705] J Infect Dis. 2006 Nov 1;194(9):1291-9 [17041856] Gynecol Oncol. 2006 Sep;102(3):530-3 [16488468] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Virology. 2005 Jun 20;337(1):76-84 [15914222] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1157-64 [15894666] J Clin Virol. 2005 Mar;32 Suppl 1:S43-51 [15753011] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1750-9378-4-8 ER - TY - JOUR T1 - Transcriptional response to mitochondrial NADH kinase deficiency in Saccharomyces cerevisiae. AN - 733128934; 19254780 AB - Yeast cells lacking the mitochondrial NADH kinase encoded by POS5 display increased sensitivity to hydrogen peroxide, a slow-growth phenotype, reduced mitochondrial function and increased levels of mitochondrial protein oxidation and mtDNA mutations. Here we examined gene expression in pos5Delta cells, comparing these data to those from cells containing deletions of superoxide dismutase-encoding genes SOD1 or SOD2. Surprisingly, stress-response genes were down-regulated in pos5Delta, sod1Delta and sod2Delta cells, implying that cells infer stress levels from mitochondrial activity rather than sensing reactive oxygen species directly. Additionally, pos5Delta, but not sod1 or sod2, cells displayed an anaerobic expression profile, indicating a defect in oxygen sensing that is specific to pos5, and is not a general stress-response. Finally, the pos5Delta expression profile is quite similar to the hap1Delta expression profile previously reported, which may indicate a shared mechanism. JF - Mitochondrion AU - Stuart, Gregory R AU - Humble, Margaret M AU - Strand, Micheline K AU - Copeland, William C AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 211 EP - 221 VL - 9 IS - 3 KW - Antifungal Agents KW - 0 KW - Mitochondrial Proteins KW - Saccharomyces cerevisiae Proteins KW - Hydrogen Peroxide KW - BBX060AN9V KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Superoxide Dismutase-1 KW - superoxide dismutase 2 KW - Phosphotransferases (Alcohol Group Acceptor) KW - EC 2.7.1.- KW - POS5 protein, S cerevisiae KW - EC 2.7.1.86 KW - Index Medicus KW - Hydrogen Peroxide -- toxicity KW - Gene Expression Regulation, Fungal KW - Antifungal Agents -- toxicity KW - Down-Regulation KW - Saccharomyces cerevisiae Proteins -- genetics KW - Superoxide Dismutase -- genetics KW - Up-Regulation KW - Saccharomyces cerevisiae -- genetics KW - Gene Expression Profiling KW - Phosphotransferases (Alcohol Group Acceptor) -- deficiency KW - Saccharomyces cerevisiae -- growth & development KW - Saccharomyces cerevisiae -- drug effects KW - Mitochondrial Proteins -- deficiency KW - Gene Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733128934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mitochondrion&rft.atitle=Transcriptional+response+to+mitochondrial+NADH+kinase+deficiency+in+Saccharomyces+cerevisiae.&rft.au=Stuart%2C+Gregory+R%3BHumble%2C+Margaret+M%3BStrand%2C+Micheline+K%3BCopeland%2C+William+C&rft.aulast=Stuart&rft.aufirst=Gregory&rft.date=2009-06-01&rft.volume=9&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Mitochondrion&rft.issn=1872-8278&rft_id=info:doi/10.1016%2Fj.mito.2009.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-07 N1 - Date created - 2009-04-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Genet. 1999 Oct;36(4):195-200 [10541856] Nucleic Acids Res. 2009 Apr;37(7):e54 [19273534] Genome. 2000 Oct;43(5):881-6 [11081979] Cell Mol Life Sci. 1999 Oct 30;56(5-6):415-26 [11212295] Genetics. 2001 Mar;157(3):1169-77 [11238402] Curr Genet. 2001 May;39(3):137-49 [11409175] Nat Biotechnol. 2001 Aug;19(8):773-6 [11479573] J Bacteriol. 2002 Jan;184(1):250-65 [11741867] Mol Microbiol. 2002 Feb;43(3):545-55 [11929514] Methods Mol Biol. 2002;197:151-7 [12013793] Methods Enzymol. 2002;350:3-41 [12073320] Yeast. 2002 Jul;19(10):825-40 [12112237] EMBO J. 2003 May 1;22(9):2015-24 [12727869] Eukaryot Cell. 2003 Aug;2(4):809-20 [12912900] Nucleic Acids Res. 2003 Oct 15;31(20):5831-7 [14530431] Yeast. 2003 Oct 15;20(13):1115-44 [14558145] Genome Res. 2003 Nov;13(11):2498-504 [14597658] Biochim Biophys Acta. 1976 Sep 13;440(3):661-74 [786371] Genetics. 1986 May;113(1):35-43 [3519363] J Mol Biol. 1988 Nov 20;204(2):263-76 [2851658] Microbiol Rev. 1992 Mar;56(1):1-11 [1579104] Genomics. 1994 Jul 1;22(1):118-26 [7959757] Curr Genet. 1995 Apr;27(5):427-34 [7586028] Yeast. 1998 Jan 30;14(2):115-32 [9483801] Proc Natl Acad Sci U S A. 1999 May 11;96(10):5446-51 [10318903] Genetics. 2005 Mar;169(3):1343-52 [15654089] Mol Cell Biol. 2005 May;25(10):4075-91 [15870279] Sci STKE. 2005 Jun 21;2005(289):pe30 [15972699] FEBS J. 2005 Jul;272(13):3337-49 [15978040] BMC Bioinformatics. 2005;6:168 [15998470] Biochim Biophys Acta. 2005 Sep 5;1709(2):169-80 [16084486] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D446-51 [16381908] Mitochondrion. 2006 Apr;6(2):94-101 [16621727] Eukaryot Cell. 2006 Sep;5(9):1468-89 [16963631] Annu Rev Genet. 2006;40:159-85 [16771627] Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jul-Aug;146(1-2):255-63 [17035097] IUBMB Life. 2008 Jul;60(7):421-9 [18459161] Mol Microbiol. 2000 Mar;35(6):1421-30 [10760143] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mito.2009.02.004 ER - TY - JOUR T1 - Nitrite inhalant abuse in antisocial youth: prevalence, patterns, and predictors. AN - 67606676; 19705675 AB - The purpose of this study was to examine the prevalence, patterns, and predictors of nitrite inhalant use in antisocial adolescents. Face-to-face interviews were conducted with 723 Missouri youth (M age = 15.5, SD = 1.2) in residential care for antisocial behavior. The lifetime prevalence of nitrite inhalant use was 1.7% (1.3% for boys; 4.3% for girls, p = .06), a figure somewhat higher than comparable estimates from the MTF and NSDUH national surveys. Most lifetime users reported nitrite use in the prior year (92%) and experienced intoxication (83%) during periods of nitrite inhalation. Nitrite users had significantly higher scores on measures of somatization, obsessive-compulsive traits, interpersonal sensitivity, impulsivity, fearlessness, suicidality, and polydrug use and were significantly more likely to have suffered a serious head injury and to be White than their non-nitrite-using counterparts. Nitrite users also reported significantly higher levels of current psychiatric distress related to periods of faintness or dizziness, hot or cold spells, difficulty making decisions, and their "mind going blank" than did non-nitrite users. Antisocial adolescent nitrite users are at substantially elevated risk for serious functional impairments given their high rates of lifetime head injury, comparatively more varied and intensive levels of involvement with psychoactive drugs, and symptom reports suggestive of psychiatric and cognitive dysfunction. JF - Journal of psychoactive drugs AU - Hall, Martin T AU - Howard, Matthew O AD - National Institute on Drug Abuse, USA. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 135 EP - 143 VL - 41 IS - 2 SN - 0279-1072, 0279-1072 KW - Nitrites KW - 0 KW - Vasodilator Agents KW - Index Medicus KW - Young Adult KW - Missouri -- epidemiology KW - Craniocerebral Trauma -- chemically induced KW - Humans KW - Mental Disorders -- chemically induced KW - Mental Disorders -- epidemiology KW - Child KW - Risk Factors KW - Administration, Inhalation KW - Adolescent KW - Female KW - Male KW - Prevalence KW - Nitrites -- administration & dosage KW - Adolescent Behavior KW - Nitrites -- adverse effects KW - Juvenile Delinquency -- statistics & numerical data KW - Vasodilator Agents -- adverse effects KW - Vasodilator Agents -- administration & dosage KW - Substance-Related Disorders -- psychology KW - Juvenile Delinquency -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67606676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Nitrite+inhalant+abuse+in+antisocial+youth%3A+prevalence%2C+patterns%2C+and+predictors.&rft.au=Hall%2C+Martin+T%3BHoward%2C+Matthew+O&rft.aulast=Hall&rft.aufirst=Martin&rft.date=2009-06-01&rft.volume=41&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-15 N1 - Date created - 2009-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of infectious complications in infants with acute lymphoblastic leukemia treated on the Children's Cancer Group Protocol 1953: a report from the Children's Oncology Group. AN - 67546997; 19648788 AB - Infants with acute lymphoblastic leukemia have a poor prognosis. The Children's Cancer Group (CCG) 1953 protocol tested the hypothesis that intensification of therapy would improve outcome for these patients. This intensified therapy resulted in better disease control, but resulted in greater toxicity. In this paper, we report the infectious complications associated with this intensified therapy. We retrospectively analyzed the infectious complications reported on the case report forms of all 115 patients enrolled on CCG 1953. Overall 495 infectious complications were identified in 115 patients. Bacterial infections occurred most frequently (74%), followed by viral (13%), fungal (11%), and protozoan (1%). Infection related mortality disproportionately occurred with viral (31%) and fungal (19%) infections. Twenty-three percent (n=26) of patients died of infectious complications, with the majority occurring during induction/intensification. Lower respiratory infections contributed to death in 12 patients and were most commonly viral (n=6) and fungal (n=3). Intensification of therapy resulted in increased infectious complications and deaths compared with previous studies. Future studies will need to focus on: (1) decreasing intensification during the first month of therapy, (2) developing targeted therapies, and (3) improving measures designed to prevent, quickly diagnose, and appropriately treat infections. JF - Journal of pediatric hematology/oncology AU - Salzer, Wanda AU - Dinndorf, Patricia AU - Dreyer, Zoann AU - Hilden, Joanne AU - Reaman, Gregory H AD - National Cancer Institute, NIH, NCI-IRB, 9030 Old Georgetown Road, Building 82, Room 215, MSC 8200, Bethesda, MD 20892, USA. salzerw@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 398 EP - 405 VL - 31 IS - 6 KW - Index Medicus KW - Infant KW - Humans KW - Retrospective Studies KW - Infection -- etiology KW - Infection -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Infection -- epidemiology KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67546997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pediatric+hematology%2Foncology&rft.atitle=Analysis+of+infectious+complications+in+infants+with+acute+lymphoblastic+leukemia+treated+on+the+Children%27s+Cancer+Group+Protocol+1953%3A+a+report+from+the+Children%27s+Oncology+Group.&rft.au=Salzer%2C+Wanda%3BDinndorf%2C+Patricia%3BDreyer%2C+Zoann%3BHilden%2C+Joanne%3BReaman%2C+Gregory+H&rft.aulast=Salzer&rft.aufirst=Wanda&rft.date=2009-06-01&rft.volume=31&rft.issue=6&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Journal+of+pediatric+hematology%2Foncology&rft.issn=1536-3678&rft_id=info:doi/10.1097%2FMPH.0b013e3181a6dec0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-04 N1 - Date created - 2009-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MPH.0b013e3181a6dec0 ER - TY - JOUR T1 - Research opportunities for pathogen reduction/inactivation of blood components: summary of an NHLBI workshop. AN - 67535733; 19392769 AB - In July 2008, a workshop sponsored by the Division of Blood Diseases and Resources of the National Heart, Lung, and Blood Institute (NHLBI) was convened to identify potential research opportunities that could advance our understanding of both the biologic and the clinical impact of the various available pathogen reduction/inactivation (PR/PI) methods of blood components (platelets [PLTs], red blood cells, and plasma) intended for allogeneic transfusion. These discussions resulted in consensus that, even though several PR/PI technologies have already been licensed and are being used in Europe and elsewhere for PLTs and plasma, concerns about possible side effects, particularly component quality and pulmonary toxicity, have impeded regulatory approval in North America (United States and Canada). Such concerns thus threaten to stall further development of these technologies. As a consequence, the NHLBI workshop participants focused on formulating a series of research-related recommendations to better understand, mitigate, and prevent these adverse effects. Other important issues identified included the need for a single method to inactivate pathogens in whole blood without damaging the various blood components; new ways to monitor the efficacy of treated components, including animal models to screen for safety; a better understanding of the effect of PR/PI-treated products on recipient alloimmunization, tolerance, and immune modulation; understanding the impact of PR/PI on various other noninfectious hazards of transfusion; and establishing methods to evaluate risk-benefit and cost-effectiveness, in particular with reference to emerging pathogens. The working group also discussed issues related to specific blood components, such as improving the process of clinical evaluation, investigating the impact of PR/PI on component storage lesions, understanding mechanisms that reduce component viability, and addressing the underlying resistance to the adoption of PR/PI-treated components. This communication summarizes the opinions of workshop participants on these issues and concludes with a list of areas for possible research that could advance the application of PR/PI methods to enhance the safety of the world's blood supplies. JF - Transfusion AU - Klein, Harvey G AU - Glynn, Simone A AU - Ness, Paul M AU - Blajchman, Morris A AU - NHLBI Working Group on Research Opportunities for the Pathogen Reduction/Inactivation of Blood Components AD - National Institutes of Health, and Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA. ; NHLBI Working Group on Research Opportunities for the Pathogen Reduction/Inactivation of Blood Components Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 1262 EP - 1268 VL - 49 IS - 6 KW - Index Medicus KW - Humans KW - Cost-Benefit Analysis KW - Plasma -- microbiology KW - Erythrocytes -- microbiology KW - Blood Component Transfusion -- adverse effects KW - Blood Component Transfusion -- methods KW - Disinfection -- methods KW - Disinfection -- economics KW - Blood-Borne Pathogens -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67535733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Research+opportunities+for+pathogen+reduction%2Finactivation+of+blood+components%3A+summary+of+an+NHLBI+workshop.&rft.au=Klein%2C+Harvey+G%3BGlynn%2C+Simone+A%3BNess%2C+Paul+M%3BBlajchman%2C+Morris+A%3BNHLBI+Working+Group+on+Research+Opportunities+for+the+Pathogen+Reduction%2FInactivation+of+Blood+Components&rft.aulast=Klein&rft.aufirst=Harvey&rft.date=2009-06-01&rft.volume=49&rft.issue=6&rft.spage=1262&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=1537-2995&rft_id=info:doi/10.1111%2Fj.1537-2995.2009.02210.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-11 N1 - Date created - 2009-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1537-2995.2009.02210.x ER - TY - JOUR T1 - [Development and evaluation of a relapse prevention tool for drug-abusing delinquents incarcerated in a juvenile classification home: a self-teaching workbook for adolescents, the "SMARPP-Jr]. AN - 67507087; 19618838 AB - The purpose of the present study is to develop a relapse prevention tool for drug-abusing delinquents incarcerated in a juvenile classification home, and to evaluate effectiveness of the tool. We prepared a self-teaching workbook for drug-abusing adolescents named "SMARPP-Jr." referring to the workbook used in the "SMARPP (Serigaya Methamphetamine Relapse Prevention Program)", and consulted about the contents of the workbook to the director, the medical doctor, and the psychologists of a juvenile classification home. After establishing the final version, we provided 59 drug-abusing delinquents incarcerated in the juvenile classification home with a relapse prevention program by this workbook, and conducted pre- and post-evaluations by the Self-efficacy Scale for Drug Dependence and the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES). The scores of SOCRATES were remarkably elevated after finishing the self-teaching workbook, while those of the Self-efficacy Scale for Drug Dependence were hardly changed. Additionally, over 60% of the participants reported that the contents of the workbook were not difficult to be understood, and approximately 90% of them also answered that this workbook was useful. The findings of the present study suggest that intervention in drug-abusing delinquents incarcerated in a juvenile classification home using the self-teaching workbook "SMARPP-Jr." may be effective to obtain insights of their drug-abuse problems and to become aware of necessity of treatment for their drug abuse. JF - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence AU - Matsumoto, Toshihiko AU - Imamura, Fumi AU - Kobayashi, Ohji AU - Chiba, Yasuhiko AU - Wada, Kiyoshi AD - National Institute of Mental Health, National Center of Neurology and Psychiatry, Ogawa-Higashi 4-1-1, Kodaira-city, Tokyo 187-8553, Japan. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 121 EP - 138 VL - 44 IS - 3 SN - 1341-8963, 1341-8963 KW - Index Medicus KW - Humans KW - Textbooks as Topic KW - Adolescent KW - Japan KW - Juvenile Delinquency KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67507087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Lancet&rft.atitle=North+and+South%3A+bridging+the+information+gap.%3A+%5B2%5D&rft.au=Green%2C+C+W&rft.aulast=Green&rft.aufirst=C&rft.date=2000-09-16&rft.volume=356&rft.issue=9234&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=The+Lancet&rft.issn=01406736&rft_id=info:doi/ LA - Japanese DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-20 N1 - Date created - 2009-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life. AN - 67466100; 19590677 AB - Exposure to endocrine-disrupting chemicals during critical developmental periods causes adverse consequences later in life; an example is prenatal exposure to the pharmaceutical diethylstilbestrol (DES). Bisphenol A (BPA), an environmental estrogen used in the synthesis of plastics, is of concern because its chemical structure resembles that of DES, and it is a "high-volume production" chemical with widespread human exposure. In this study we investigated whether prenatal BPA causes long-term adverse effects in female reproductive tissues in an experimental animal model previously shown useful in studying effects of prenatal DES. Timed pregnant CD-1 mice were treated on days 9-16 of gestation with BPA (0.1, 1, 10, 100, or 1,000 mug/kg/day). After delivery, pups were held for 18 months; reproductive tissues were then evaluated. Ovarian cysts were significantly increased in the 1-mug/kg BPA group; ovarian cyst-adenomas were seen in the other three BPA-treated groups but not in corn-oil controls. We observed increased progressive proliferative lesions of the oviduct after BPA treatment, similar to those described in response to DES. Further, although not statistically different from the controls, prominent mesonephric (Wolffian) remnants and squamous metaplasia of the uterus, as well as vaginal adenosis, were present in BPA-treated mice, similar to lesions reported following DES treatment. More severe pathologies observed in some BPA-treated animals included atypical hyperplasia and stromal polyps of the uterus; sarcoma of the uterine cervix; and mammary adenocarcinoma. We did not observe these lesions in controls. These data suggest that BPA causes long-term adverse reproductive and carcinogenic effects if exposure occurs during critical periods of differentiation. JF - Environmental health perspectives AU - Newbold, Retha R AU - Jefferson, Wendy N AU - Padilla-Banks, Elizabeth AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. newbold1@niehs.nih.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 879 EP - 885 VL - 117 IS - 6 KW - Benzhydryl Compounds KW - 0 KW - Endocrine Disruptors KW - Phenols KW - Water Pollutants, Chemical KW - Diethylstilbestrol KW - 731DCA35BT KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - uterus KW - ovary KW - DES KW - development KW - carcinogenesis KW - endocrine disruptors KW - toxicology KW - BPA KW - diethylstilbestrol KW - reproduction KW - Endocrine Disruptors -- toxicity KW - Animals KW - Diethylstilbestrol -- toxicity KW - Ovary -- drug effects KW - Mice KW - Uterus -- drug effects KW - Female KW - Pregnancy KW - Reproduction -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Phenols -- toxicity KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67466100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Prenatal+exposure+to+bisphenol+a+at+environmentally+relevant+doses+adversely+affects+the+murine+female+reproductive+tract+later+in+life.&rft.au=Newbold%2C+Retha+R%3BJefferson%2C+Wendy+N%3BPadilla-Banks%2C+Elizabeth&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2009-06-01&rft.volume=117&rft.issue=6&rft.spage=879&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0800045 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-23 N1 - Date created - 2009-07-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Matern Child Nutr. 2005 Jul;1(3):130-41 [16881892] Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12033-8 [16882715] Mol Endocrinol. 2006 Sep;20(9):2141-55 [16613991] Environ Health Perspect. 2007 Jan;115(1):80-6 [17366824] Reprod Toxicol. 2007 Apr-May;23(3):383-90 [17123778] Reprod Toxicol. 2007 Apr-May;23(3):290-6 [17321108] Reprod Toxicol. 2007 Aug-Sep;24(2):178-98 [17628395] Reprod Toxicol. 2007 Aug-Sep;24(2):253-8 [17804194] Horm Behav. 2006 Jun;50(1):85-93 [16540110] Reprod Toxicol. 2007 Aug-Sep;24(2):139-77 [17825522] J Atheroscler Thromb. 2007 Oct;14(5):245-52 [17938543] Environ Health Perspect. 2008 Jan;116(1):39-44 [18197297] Epidemiology. 2008 Mar;19(2):251-7 [18223485] Reprod Toxicol. 2008 Feb;25(2):169-76 [18295446] Environ Health Perspect. 1993 Oct;101(5):372-7 [8119245] Development. 1994 Feb;120(2):335-45 [7908629] Am J Pathol. 1986 Sep;124(3):405-11 [3766701] Cancer Res. 1990 Dec 1;50(23):7677-81 [2174729] Carcinogenesis. 1992 Feb;13(2):145-51 [1740003] Eur J Cancer. 1992;28A(6-7):1182-9 [1627392] Eur J Cancer. 1992;29A(1):149-55 [1445734] Environ Health Perspect. 1992 Nov;98:39-43 [1486860] Environ Health Perspect. 1995 Jun;103(6):608-12 [7556016] Prog Clin Biol Res. 1996;394:175-82 [8778796] Prog Clin Biol Res. 1996;394:425-45 [8778808] Environ Health Perspect. 1996 Mar;104(3):298-305 [8919768] Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2056-61 [9050904] Biol Reprod. 1997 Dec;57(6):1338-45 [9408238] Carcinogenesis. 1997 Dec;18(12):2293-8 [9450472] Int J Cancer. 1998 Jan 19;75(2):290-4 [9462721] Dev Biol. 1998 May 15;197(2):141-54 [9630742] Nat Genet. 1998 Nov;20(3):228-30 [9806537] J Perinatol. 2008 Apr;28(4):258-63 [18273031] Nature. 1999 Oct 21;401(6755):763-4 [10548101] Lab Anim Sci. 1999 Oct;49(5):530-6 [10551455] Cancer Res. 2000 Jan 15;60(2):235-7 [10667565] Int J Cancer. 2000 Apr 15;86(2):151-4 [10738239] Environ Health Perspect. 2000 Oct;108 Suppl 5:769-73 [11035980] Cancer Res. 2001 Jun 1;61(11):4325-8 [11389053] Environ Health Perspect. 2001 Jul;109(7):675-80 [11485865] Biol Reprod. 2001 Oct;65(4):1215-23 [11566746] Biochem Biophys Res Commun. 2002 Feb 15;291(1):76-8 [11829464] Neoplasia. 2002 Mar-Apr;4(2):98-102 [11896564] Environ Health Perspect. 2002 Apr;110(4):427-31 [11940462] Reprod Toxicol. 2002 Mar-Apr;16(2):117-22 [11955942] Toxicol Pathol. 2002 Sep-Oct;30(5):611-6 [12371671] Environ Health Perspect. 2002 Nov;110(11):A703-7 [12417499] Evol Dev. 2003 Jan-Feb;5(1):67-75 [12492412] Curr Biol. 2003 Apr 1;13(7):546-53 [12676084] Obes Res. 2003 Apr;11(4):496-506 [12690076] Regul Toxicol Pharmacol. 2003 Jun;37(3):407-8; author reply 409-10 [12758220] J Pediatr Hematol Oncol. 2003 Aug;25(8):635-6 [12902917] J Obstet Gynaecol. 2003 Sep;23(5):555-60 [12963520] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13994-9 [14610279] Toxicol Sci. 2003 Dec;76(2):247-9 [14677558] Toxicol Appl Pharmacol. 2004 Sep 1;199(2):142-50 [15313586] Cancer Res. 1980 Nov;40(11):3988-99 [7193511] Obstet Gynecol Annu. 1981;10:267-78 [7024873] Cancer Res. 1982 May;42(5):2003-11 [7066910] Teratology. 1983 Jun;27(3):417-26 [6879463] Am J Pathol. 1984 Nov;117(2):333-5 [6437233] Cancer Res. 1985 Oct;45(10):5145-50 [4027990] Teratog Carcinog Mutagen. 1985;5(6):473-80 [2874632] Neoplasia. 2004 Sep-Oct;6(5):584-94 [15548368] Biol Reprod. 2005 Jun;72(6):1344-51 [15689538] Birth Defects Res A Clin Mol Teratol. 2005 Jul;73(7):478-80 [15959888] Environ Health Perspect. 2005 Aug;113(8):969-77 [16079065] Environ Health Perspect. 2006 Jan;114(1):106-12 [16393666] J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 2;831(1-2):110-5 [16377264] Endocrinology. 2006 Jun;147(6 Suppl):S50-5 [16690801] Endocrinology. 2006 Jun;147(6 Suppl):S11-7 [16690809] Cancer Res. 2006 Jun 1;66(11):5624-32 [16740699] Comment In: Environ Health Perspect. 2009 Jun;117(6):A256 [19590670] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0800045 ER - TY - JOUR T1 - N-methyldecahydroquinolines: an unexpected class of alkaloids from Amazonian poison frogs (Dendrobatidae). AN - 67419097; 19432407 AB - The dominant alkaloids previously identified in skin extracts of Amazonian dendrobatid frogs of the genus Ameerega are histrionicotoxins and 2,5-disubstituted decahydroquinolines. Analysis of alkaloids in skin extracts of Ameerega picta from Bolivia revealed that the alkaloid 257A, previously reported as a 2,5-disubstituted decahydroquinoline, is an N-methyl-2,5-disubstituted decahydroquinoline. We characterized alkaloids of another 12 of the more than 25 species recently assigned to the genus Ameerega, and five additional N-methyldecahydroquinolines were identified. In some cases, the relative configuration of the N-methyldecahydroquinolines was determined by comparison with the N-methylated products prepared from the corresponding 2,5-disubstituted decahydroquinolines of known relative configuration. A dietary source for N-methyldecahydroquinolines is unknown; however, myrmicine ants are the likely source for the 2,5-disubstituted decahydroquinolines. The alkaloids in skin extracts of three species of another genus of Amazonian poison frog, Adelphobates, were also characterized, but N-methyldecahydroquinolines were not detected. JF - Journal of natural products AU - Daly, John W AU - Ware, Nathaniel AU - Saporito, Ralph A AU - Spande, Thomas F AU - Garraffo, H Martin AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892-0820, USA. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 1110 EP - 1114 VL - 72 IS - 6 KW - Alkaloids KW - 0 KW - Amphibian Venoms KW - Quinolines KW - Index Medicus KW - Molecular Structure KW - Skin -- chemistry KW - Animals KW - Skin -- secretion KW - Bolivia KW - Amphibian Venoms -- chemistry KW - Amphibian Venoms -- isolation & purification KW - Alkaloids -- chemistry KW - Quinolines -- isolation & purification KW - Amphibian Venoms -- pharmacology KW - Quinolines -- chemistry KW - Quinolines -- pharmacology KW - Anura -- genetics KW - Alkaloids -- isolation & purification KW - Alkaloids -- pharmacology KW - Alkaloids -- analysis KW - Anura -- physiology KW - Quinolines -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67419097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+natural+products&rft.atitle=N-methyldecahydroquinolines%3A+an+unexpected+class+of+alkaloids+from+Amazonian+poison+frogs+%28Dendrobatidae%29.&rft.au=Daly%2C+John+W%3BWare%2C+Nathaniel%3BSaporito%2C+Ralph+A%3BSpande%2C+Thomas+F%3BGarraffo%2C+H+Martin&rft.aulast=Daly&rft.aufirst=John&rft.date=2009-06-01&rft.volume=72&rft.issue=6&rft.spage=1110&rft.isbn=&rft.btitle=&rft.title=Journal+of+natural+products&rft.issn=1520-6025&rft_id=info:doi/10.1021%2Fnp900094v LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-23 N1 - Date created - 2009-06-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Nat Prod. 2001 Apr;64(4):421-7 [11325220] Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):13996-4001 [12381780] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11092-7 [12960405] Proc Natl Acad Sci U S A. 2004 May 25;101(21):8045-50 [15128938] Toxicon. 1978;16(2):163-88 [635931] Toxicon. 1987;25(10):1023-95 [3321567] Toxicon. 2007 Nov;50(6):757-78 [17706737] J Chem Ecol. 2005 Oct;31(10):2403-15 [16195851] J Nat Prod. 2005 Oct;68(10):1556-75 [16252926] J Chem Ecol. 2006 Apr;32(4):795-814 [16718571] Mol Phylogenet Evol. 2006 Oct;41(1):149-64 [16815043] Proc Natl Acad Sci U S A. 2007 May 22;104(21):8885-90 [17502597] J Nat Prod. 1993 Mar;56(3):357-73 [8482947] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/np900094v ER - TY - JOUR T1 - Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. AN - 67412578; 19470598 AB - Base excision repair (BER) is the major pathway for removing mutagenic and cytotoxic oxidative and alkylation DNA modifications. Using a catalytically inactive, dominant negative protein form of human APE1, termed ED, which binds with high affinity to substrate DNA and blocks subsequent repair steps, we assessed the role of BER in mediating cellular resistance to clinically relevant alkylating drugs and antimetabolites. Colony formation assays revealed that ED expression enhanced cellular sensitivity to melphalan not at all; to decarbazine, thiotepa, busulfan and carmustine moderately (1.2- to 2.4-fold); and to streptozotocin and temozolomide significantly (2.0- to 5.3-fold). The effectiveness of ED to promote enhanced cytotoxicity generally correlated with the agent's (a) monofunctional nature, (b) capacity to induce N(7)-guanine and N(3)-adenine modifications, and (c) inability to generate O(6)-guanine adducts or DNA cross-links. ED also enhanced the cell killing potency of the antimetabolite troxacitabine, apparently by blocking the processing of DNA strand breaks, yet had no effect on the cytotoxicity of gemcitabine, results that agree well with the known efficiency of APE1 to excise these nucleoside analogues from DNA. Most impressively, ED expression produced an approximately 5- and 25-fold augmentation of the cell killing effect of 5-fluorouracil and 5-fluorodeoxyuridine, respectively, implicating BER in the cellular response to such antimetabolites; the increased 5-fluorouracil sensitivity was associated with an accumulation of abasic sites and active caspase-positive staining. Our data suggest that APE1, and BER more broadly, is a potential target for inactivation in anticancer treatment paradigms that involve select alkylating agents or antimetabolites. JF - Molecular cancer research : MCR AU - McNeill, Daniel R AU - Lam, Wing AU - DeWeese, Theodore L AU - Cheng, Yung-Chi AU - Wilson, David M AD - Biomedical Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 897 EP - 906 VL - 7 IS - 6 KW - Antimetabolites, Antineoplastic KW - 0 KW - Antineoplastic Agents, Alkylating KW - APEX1 protein, human KW - EC 4.2.99.18 KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Animals KW - Cricetulus KW - Cell Survival -- drug effects KW - Humans KW - Apoptosis -- drug effects KW - Fluorouracil -- pharmacology KW - CHO Cells KW - G1 Phase -- drug effects KW - Mutation KW - Cell Cycle -- drug effects KW - Cricetinae KW - Neoplasms -- drug therapy KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- genetics KW - Neoplasms -- pathology KW - DNA Repair KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- metabolism KW - Antineoplastic Agents, Alkylating -- pharmacology KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- biosynthesis KW - Neoplasms -- genetics KW - Neoplasms -- metabolism KW - Antimetabolites, Antineoplastic -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67412578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+research+%3A+MCR&rft.atitle=Impairment+of+APE1+function+enhances+cellular+sensitivity+to+clinically+relevant+alkylators+and+antimetabolites.&rft.au=McNeill%2C+Daniel+R%3BLam%2C+Wing%3BDeWeese%2C+Theodore+L%3BCheng%2C+Yung-Chi%3BWilson%2C+David+M&rft.aulast=McNeill&rft.aufirst=Daniel&rft.date=2009-06-01&rft.volume=7&rft.issue=6&rft.spage=897&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+research+%3A+MCR&rft.issn=1557-3125&rft_id=info:doi/10.1158%2F1541-7786.MCR-08-0519 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-18 N1 - Date created - 2009-06-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Oncol. 2006 May;17 Suppl 5:v7-12 [16807468] Mol Pharmacol. 2006 May;69(5):1607-14 [16481390] Mol Cancer Res. 2007 Jan;5(1):61-70 [17259346] Cancer Res. 2007 Feb 1;67(3):940-5 [17283124] Mol Aspects Med. 2007 Jun-Aug;28(3-4):375-95 [17560642] Yeast. 2007 Oct;24(10):861-70 [17640085] Pharmacol Res. 2007 Oct;56(4):275-87 [17897837] Gastroenterology. 2007 Dec;133(6):1858-68 [18054558] Environ Mol Mutagen. 2007 Dec;48(9):772-82 [17948279] Nat Rev Cancer. 2008 Mar;8(3):193-204 [18256616] Biochem Pharmacol. 2008 Sep 15;76(6):697-706 [18599024] Cell Mol Life Sci. 2009 Mar;66(5):788-99 [18979208] Cancer Treat Rev. 2000 Aug;26(4):257-68 [10913381] J Biol Chem. 2000 Oct 6;275(40):31009-15 [10906132] Nature. 2001 May 17;411(6835):366-74 [11357144] Nature. 2002 Feb 7;415(6872):655-9 [11832948] J Mol Biol. 2002 Feb 22;316(3):853-66 [11866537] Clin Cancer Res. 2002 Sep;8(9):2985-91 [12231545] Clin Cancer Res. 2002 Sep;8(9):3008-18 [12231548] Mutat Res. 2002 Dec;512(2-3):121-34 [12464347] Oncogene. 2002 Dec 16;21(58):8935-48 [12483510] Nat Rev Cancer. 2003 May;3(5):330-8 [12724731] J Mol Biol. 2003 Jul 25;330(5):1027-37 [12860125] Oncogene. 2003 Dec 8;22(56):9063-74 [14663485] Mol Cancer Ther. 2004 Jun;3(6):679-86 [15210853] Somat Cell Mol Genet. 1999 Nov;25(5-6):253-62 [15328905] Anticancer Res. 2004 Jul-Aug;24(4):2127-34 [15330152] DNA Repair (Amst). 2004 Nov 2;3(11):1389-407 [15380096] Br J Cancer. 2004 Sep 13;91(6):1166-73 [15316562] J Cancer Res Clin Oncol. 1986;112(3):196-204 [3536942] Exp Cell Res. 1988 Mar;175(1):184-91 [3345800] Mutat Res. 1990 Jul;231(1):11-30 [2195323] Cancer Res. 1992 Apr 1;52(7):2008-11 [1551130] Mutat Res. 1994 Jul;315(1):55-63 [7517011] Biochemistry. 1994 Aug 9;33(31):9045-51 [8049205] Mutat Res. 1994 Dec;318(3):205-26 [7527485] Nucleic Acids Res. 1994 Nov 25;22(23):4884-9 [7800476] Mutat Res. 1996 Aug 17;355(1-2):41-57 [8781576] Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8919-23 [8799128] Nucleic Acids Res. 1997 Jun 15;25(12):2495-500 [9171104] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9232-7 [9256465] Cancer Res. 1998 Jan 15;58(2):222-5 [9443396] Mutat Res. 1998 Oct 21;409(1):17-29 [9806499] Mol Cell. 2005 Feb 4;17(3):463-70 [15694346] J Biol Chem. 2005 Feb 18;280(7):5516-26 [15611052] Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5739-43 [15824325] Cancer Res. 2005 Jul 15;65(14):6394-400 [16024643] Nucleic Acids Res. 2005;33(15):4711-24 [16113242] Clin Cancer Res. 2005 Oct 15;11(20):7405-14 [16243814] DNA Repair (Amst). 2005 Dec 8;4(12):1442-9 [16199212] Cancer Treat Rev. 2005 Dec;31(8):603-17 [16298073] Nucleic Acids Res. 2006;34(1):140-51 [16407331] Clin Cancer Res. 2006 Jan 15;12(2):328-31 [16428468] Future Oncol. 2005 Dec;1(6):747-54 [16556052] Chem Res Toxicol. 2006 Dec;19(12):1580-94 [17173371] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1541-7786.MCR-08-0519 ER - TY - JOUR T1 - Final analysis of a phase II trial using sorafenib for metastatic castration-resistant prostate cancer. AN - 67404867; 19154507 AB - To determine if sorafenib is associated with an improved 4-month probability of progression-free survival, using radiographic and clinical criteria alone, in patients with metastatic castration-resistant prostate cancer. Secondary endpoints included pharmacokinetics, toxicity analysis and overall survival. The study was an open-label, phase II, two-stage design, focusing on the results from the second stage, as criteria for progression were modified after completing the first stage. Sorafenib was given at a dose of 400 mg orally twice daily in 28-day cycles. Clinical and laboratory assessments were done every 4 weeks, and radiographic scans were obtained every 8 weeks. Twenty-four patients were accrued in the second stage; the median (range) age was 66 (49-85) years, the on-study prostate-specific antigen level was 68.45 (5.8-995) ng/mL, the Gleason score 8 (6-9) and Eastern Cooperative Oncology Group status 1 (in 17 patients). Of the 24 patients, 21 had previous chemotherapy with docetaxel. All patients had bony metastases, either alone (in 11) or with soft-tissue disease (in 13). One patient had a partial response; 10 patients had stable disease (median duration 18 weeks, range 15-48). At a median potential follow-up of 27.2 months, the median progression-free survival was 3.7 months and the median overall survival was 18.0 months. For the whole trial of 46 patients the median survival was 18.3 months. Most frequent toxicities included hand-foot skin reaction (grade 2 in nine patients, grade 3 in three), rash, abnormalities in liver function tests, and fatigue. Sorafenib has moderate activity as a second-line treatment for metastatic castration-resistant prostate cancer. JF - BJU international AU - Aragon-Ching, Jeanny B AU - Jain, Lokesh AU - Gulley, James L AU - Arlen, Philip M AU - Wright, John J AU - Steinberg, Seth M AU - Draper, David AU - Venitz, Jürgen AU - Jones, Elizabeth AU - Chen, Clara C AU - Figg, William D AU - Dahut, William L AD - Medical Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 1636 EP - 1640 VL - 103 IS - 12 KW - Antineoplastic Agents KW - 0 KW - Benzenesulfonates KW - Phenylurea Compounds KW - Pyridines KW - Niacinamide KW - 25X51I8RD4 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - sorafenib KW - 9ZOQ3TZI87 KW - raf Kinases KW - EC 2.7.11.1 KW - Index Medicus KW - Disease-Free Survival KW - Aged, 80 and over KW - Humans KW - Treatment Outcome KW - Niacinamide -- analogs & derivatives KW - Neoplasm Metastasis KW - Aged KW - Middle Aged KW - Gonadotropin-Releasing Hormone -- therapeutic use KW - raf Kinases -- antagonists & inhibitors KW - Male KW - Orchiectomy KW - Benzenesulfonates -- therapeutic use KW - Soft Tissue Neoplasms -- mortality KW - Bone Neoplasms -- mortality KW - Soft Tissue Neoplasms -- drug therapy KW - Pyridines -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Soft Tissue Neoplasms -- secondary KW - Antineoplastic Agents -- adverse effects KW - Prostatic Neoplasms -- mortality KW - Benzenesulfonates -- adverse effects KW - Prostatic Neoplasms -- surgery KW - Bone Neoplasms -- drug therapy KW - Antineoplastic Agents -- therapeutic use KW - Pyridines -- adverse effects KW - Bone Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67404867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BJU+international&rft.atitle=Final+analysis+of+a+phase+II+trial+using+sorafenib+for+metastatic+castration-resistant+prostate+cancer.&rft.au=Aragon-Ching%2C+Jeanny+B%3BJain%2C+Lokesh%3BGulley%2C+James+L%3BArlen%2C+Philip+M%3BWright%2C+John+J%3BSteinberg%2C+Seth+M%3BDraper%2C+David%3BVenitz%2C+J%C3%BCrgen%3BJones%2C+Elizabeth%3BChen%2C+Clara+C%3BFigg%2C+William+D%3BDahut%2C+William+L&rft.aulast=Aragon-Ching&rft.aufirst=Jeanny&rft.date=2009-06-01&rft.volume=103&rft.issue=12&rft.spage=1636&rft.isbn=&rft.btitle=&rft.title=BJU+international&rft.issn=1464-410X&rft_id=info:doi/10.1111%2Fj.1464-410X.2008.08327.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-10 N1 - Date created - 2009-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] J Clin Oncol. 2008 May 1;26(13):2178-85 [18445842] Control Clin Trials. 1989 Mar;10(1):1-10 [2702835] Am J Pathol. 1993 Aug;143(2):401-9 [7688183] Clin Cancer Res. 2005 Aug 1;11(15):5472-80 [16061863] Ann Oncol. 2005 Oct;16(10):1688-94 [16006586] Clin Cancer Res. 2006 Jan 1;12(1):144-51 [16397036] Urology. 2006 Jun;67(6):1235-40 [16765185] Nat Rev Drug Discov. 2006 Oct;5(10):835-44 [17016424] Oncologist. 2007 Apr;12(4):426-37 [17470685] Cancer. 2007 Aug 1;110(3):556-63 [17577218] Br J Cancer. 2007 Dec 3;97(11):1480-5 [18040273] Clin Cancer Res. 2008 Jan 1;14(1):209-14 [18172272] Cancer. 2008 Feb 1;112(3):521-6 [18085595] J Pharm Biomed Anal. 2008 Jan 22;46(2):362-7 [18309574] J Clin Oncol. 2008 Mar 1;26(7):1148-59 [18309951] Ann Oncol. 2008 Apr;19(4):746-51 [18056648] N Engl J Med. 2004 Oct 7;351(15):1502-12 [15470213] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1464-410X.2008.08327.x ER - TY - JOUR T1 - Modeling thyroid cancer in the mouse. AN - 67352838; 19358084 AB - Thyroid carcinomas, the most common endocrine tumors in humans, have an increasing incidence in the U.S. and worldwide. There are four major types of thyroid cancers: papillary, follicular, anaplastic, and medullary carcinomas. In recent years, significant progress has been made in the identification of genetic alterations in thyroid carcinomas, particularly, papillary and medullary thyroid cancers. Mouse models of thyroid cancer are valuable tools in elucidating molecular genetic changes underlying thyroid carcinogenesis and in identifying potential molecular targets for therapeutic intervention. Representative mouse models of papillary, follicular, and medullary carcinomas are reviewed here with particular emphasis on those for follicular thyroid carcinomas. Challenges for further development in the modeling of thyroid cancer will also be discussed. JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme AU - Zhu, X-G AU - Cheng, S-Y AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 488 EP - 499 VL - 41 IS - 6 KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Animals KW - Humans KW - Thyroid Neoplasms -- genetics KW - Carcinoma -- pathology KW - Thyroid Neoplasms -- therapy KW - Carcinoma -- drug therapy KW - Disease Models, Animal KW - Thyroid Neoplasms -- pathology KW - Mice KW - Carcinoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67352838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hormone+and+metabolic+research+%3D+Hormon-+und+Stoffwechselforschung+%3D+Hormones+et+metabolisme&rft.atitle=Modeling+thyroid+cancer+in+the+mouse.&rft.au=Zhu%2C+X-G%3BCheng%2C+S-Y&rft.aulast=Zhu&rft.aufirst=X-G&rft.date=2009-06-01&rft.volume=41&rft.issue=6&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Hormone+and+metabolic+research+%3D+Hormon-+und+Stoffwechselforschung+%3D+Hormones+et+metabolisme&rft.issn=1439-4286&rft_id=info:doi/10.1055%2Fs-0029-1215572 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-06 N1 - Date created - 2009-06-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocr Pathol. 2002 Winter;13(4):271-88 [12665646] Cancer Res. 2003 Apr 1;63(7):1454-7 [12670889] J Clin Endocrinol Metab. 2003 May;88(5):2318-26 [12727991] Dev 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[9061850] Lab Invest. 1997 Mar;76(3):307-18 [9121114] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3330-5 [9096393] Horm Res. 1997;47(4-6):137-9 [9167944] Endocrinology. 1997 Aug;138(8):3133-40 [9231760] Oncogene. 1998 Jan 15;16(2):167-77 [9464534] Oncogene. 1998 Sep 24;17(12):1625-8 [9794240] Biol Cell. 1998 Sep;90(5):369-80 [9835011] Cancer Res. 1998 Dec 1;58(23):5523-8 [9850089] Cancer Res. 1999 Apr 15;59(8):1811-5 [10213482] Langenbecks Arch Surg. 1999 Feb;384(1):16-23 [10367625] Oncogene. 1999 Jun 17;18(24):3659-65 [10380889] Clin Endocrinol (Oxf). 1999 Apr;50(4):529-35 [10468914] J Biol Chem. 2004 Nov 5;279(45):46868-75 [15331589] Endocr Pathol. 2004 Winter;15(4):319-27 [15681856] J Surg Oncol. 2005 Mar 1;89(3):122-9 [15719378] Cancer Res. 2005 May 15;65(10):4238-45 [15899815] J Natl Cancer Inst. 2005 May 18;97(10):703-5 [15900034] J Natl Cancer Inst. 2005 May 18;97(10):724-32 [15900042] Am J Epidemiol. 2005 Jun 1;161(11):1056-65 [15901626] Cancer. 2005 Jun 1;103(11):2261-8 [15880523] Endocr Relat Cancer. 2005 Jun;12(2):245-62 [15947100] Cancer Genet Cytogenet. 2005 Sep;161(2):104-9 [16102579] Endocrinology. 2005 Oct;146(10):4456-63 [16002527] Expert Rev Mol Diagn. 2005 Nov;5(6):927-46 [16255634] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1780-5 [16446424] Oncogene. 2006 May 4;25(19):2736-47 [16314832] Oncogene. 2006 Aug 31;25(39):5467-74 [16785999] J Clin Invest. 2006 Nov;116(11):2972-84 [17039256] Endocrinology. 2007 Mar;148(3):936-41 [16946010] Endocrinology. 2007 Mar;148(3):1306-12 [17170101] Steroids. 2007 Feb;72(2):171-9 [17169389] Carcinogenesis. 2007 May;28(5):932-9 [17127711] Mol Cell Biol. 2007 Sep;27(17):6116-26 [17606624] Endocr Relat Cancer. 2007 Dec;14(4):957-77 [18045949] Carcinogenesis. 2007 Dec;28(12):2451-8 [17660507] Expert Rev Mol Diagn. 2008 Jan;8(1):83-95 [18088233] Oncogene. 2008 Jan 31;27(6):823-30 [17653082] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Expert Rev Anticancer Ther. 2008 Apr;8(4):625-32 [18402529] Horm Metab Res. 2008 May;40(5):323-8 [18491251] Endocrinol Metab Clin North Am. 2008 Jun;37(2):363-74, viii [18502331] Mol Cell Biol. 2008 Jul;28(14):4598-608 [18474620] Endocrinology. 2008 Oct;149(10):5107-17 [18583418] Br J Cancer. 2008 Dec 2;99(11):1874-83 [18985036] Cancer Invest. 2008 Nov;26(9):948-55 [18798058] Am J Pathol. 2003 Apr;162(4):1053-60 [12651598] Cancer Epidemiol Biomarkers Prev. 1999 Nov;8(11):991-7 [10566554] Pathol Res Pract. 2000;196(1):1-7 [10674266] Thyroid. 2000 Jan;10(1):19-23 [10691309] Am J Pathol. 2000 Aug;157(2):671-7 [10934169] Oncogene. 2000 Aug 10;19(34):3948-54 [10951588] Science. 2000 Aug 25;289(5483):1357-60 [10958784] Science. 2000 Oct 6;290(5489):138-41 [11021799] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Oncogene. 2000 Nov 23;19(50):5729-35 [11126359] Toxicol Pathol. 2001 Jan-Feb;29(1):8-33 [11215688] EMBO Rep. 2000 Aug;1(2):127-32 [11265751] EMBO Rep. 2000 Aug;1(2):133-9 [11265752] Eur J Surg Oncol. 2001 Mar;27(2):157-61 [11289751] Nature. 2001 Apr 26;410(6832):1111-6 [11323676] Genes Dev. 2001 Dec 15;15(24):3243-8 [11751630] Nature. 2002 Jun 27;417(6892):949-54 [12068308] Endocr Pathol. 2002 Spring;13(1):3-16 [12114746] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15462-7 [12432093] Thyroid. 2002 Nov;12(11):963-9 [12490073] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1055/s-0029-1215572 ER - TY - JOUR T1 - Occupational exposure to magnetic fields and the risk of brain tumors. AN - 67347209; 19234232 AB - We investigated the association between occupational exposure to extremely low-frequency magnetic fields (MFs) and the risk of glioma and meningioma. Occupational exposure to MF was assessed for 489 glioma cases, 197 meningioma cases, and 799 controls enrolled in a hospital-based case-control study. Lifetime occupational history questionnaires were administered to all subjects; for 24% of jobs, these were supplemented with job-specific questionnaires, or "job modules," to obtain information on the use of electrically powered tools or equipment at work. Job-specific quantitative estimates for exposure to MF in milligauss were assigned using a previously published job exposure matrix (JEM) with modification based on the job modules. Jobs were categorized as 1.5 to or =3.0 mG. Four exposure metrics were evaluated: (1) maximum exposed job; (2) total years of exposure >1.5 mG; (3) cumulative lifetime exposure; and (4) average lifetime exposure. Odds ratios (ORs) were calculated using unconditional logistic regression with adjustment for the age, gender, and hospital site. The job modules increased the number of jobs with exposure > or =3.0 mG from 4% to 7% relative to the JEM. No statistically significant elevation in ORs or trends in ORs across exposure categories was observed using four different exposure metrics for the three tumor types analyzed. Occupational exposure to MFs assessed using job modules was not associated with an increase in the risk for glioma, glioblastoma, or meningioma among the subjects evaluated in this study. JF - Neuro-oncology AU - Coble, Joseph B AU - Dosemeci, Mustafa AU - Stewart, Patricia A AU - Blair, Aaron AU - Bowman, Joseph AU - Fine, Howard A AU - Shapiro, William R AU - Selker, Robert G AU - Loeffler, Jay S AU - Black, Peter M AU - Linet, Martha S AU - Inskip, Peter D AD - National Cancer Institute, Rockville, MD 20892, USA. jcoble@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 242 EP - 249 VL - 11 IS - 3 SN - 1522-8517, 1522-8517 KW - Index Medicus KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Brain Neoplasms -- epidemiology KW - Electromagnetic Fields -- adverse effects KW - Occupational Exposure -- adverse effects KW - Brain Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67347209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuro-oncology&rft.atitle=Occupational+exposure+to+magnetic+fields+and+the+risk+of+brain+tumors.&rft.au=Coble%2C+Joseph+B%3BDosemeci%2C+Mustafa%3BStewart%2C+Patricia+A%3BBlair%2C+Aaron%3BBowman%2C+Joseph%3BFine%2C+Howard+A%3BShapiro%2C+William+R%3BSelker%2C+Robert+G%3BLoeffler%2C+Jay+S%3BBlack%2C+Peter+M%3BLinet%2C+Martha+S%3BInskip%2C+Peter+D&rft.aulast=Coble&rft.aufirst=Joseph&rft.date=2009-06-01&rft.volume=11&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Neuro-oncology&rft.issn=15228517&rft_id=info:doi/10.1215%2F15228517-2009-002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-06-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: AIHAJ. 2000 Mar-Apr;61(2):174-82 [10782189] Occup Environ Med. 2009 Feb;66(2):72-80 [18805878] Bioelectromagnetics. 2002 Jan;23(1):59-67 [11793406] Int J Epidemiol. 2002 Feb;31(1):210-7 [11914323] IARC Monogr Eval Carcinog Risks Hum. 2002;80:1-395 [12071196] Am J Ind Med. 2002 Sep;42(3):214-27 [12210690] J Natl Cancer Inst. 2002 Oct 16;94(20):1555-63 [12381708] Cancer Causes Control. 2003 Mar;14(2):139-50 [12749719] Am J Ind Med. 2004 May;45(5):395-407 [15095422] J Natl Cancer Inst. 1987 Aug;79(2):233-8 [3474455] J Expo Anal Environ Epidemiol. 1993 Jan-Mar;3(1):1-22 [8518543] Cancer Causes Control. 1993 Sep;4(5):465-76 [8218879] Am J Epidemiol. 1995 Jan 15;141(2):123-34 [7817968] Environ Health Perspect. 1995 Mar;103 Suppl 2:69-74 [7614951] Am J Epidemiol. 1996 Mar 1;143(5):480-6 [8610663] Epidemiol Rev. 1995;17(2):382-414 [8654518] J Occup Environ Med. 1995 Dec;37(12):1327-41 [8749738] Int J Epidemiol. 1996 Aug;25(4):744-52 [8921451] Phys Med Biol. 1997 Jan;42(1):67-76 [9015809] Occup Environ Med. 1997 Jan;54(1):7-13 [9072027] Am Ind Hyg Assoc J. 1998 Jan;59(1):39-44 [9438334] Am J Ind Med. 1998 Mar;33(3):247-55 [9481423] Am J Epidemiol. 2005 Jan 15;161(2):136-46 [15632263] J Natl Cancer Inst. 2006 Nov 1;98(21):1528-37 [17077355] Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2514-20 [17164378] J Occup Environ Hyg. 2007 Sep;4(9):715-28 [17654227] Am J Epidemiol. 2008 Apr 15;167(8):976-85 [18299277] Environ Health Perspect. 2001 Dec;109 Suppl 6:911-33 [11744509] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1215/15228517-2009-002 ER - TY - JOUR T1 - Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression. AN - 67346733; 19396528 AB - During rodent mammary gland involution there is a dramatic increase in the expression of the transforming growth factor-beta isoform, TGF-beta3. The TGF-betas are multifunctional cytokines which play important roles in wound healing and in carcinogenesis. The responses that are activated in the remodeling of the gland during involution have many similarities with the wound healing process and have been postulated to generate a mammary stroma that provides a microenvironment favoring tumor progression. In this review we will discuss the putative role of TGF-beta during involution, as well as its effects on the mammary microenvironment and possible implications for pregnancy-associated tumorigenesis. JF - Journal of mammary gland biology and neoplasia AU - Flanders, Kathleen C AU - Wakefield, Lalage M AD - Laboratory of Cancer Biology & Genetics, National Cancer Institute, Bethesda, MD 20892, USA. flanderk@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 131 EP - 144 VL - 14 IS - 2 KW - Protein Isoforms KW - 0 KW - RNA, Messenger KW - RNA, Neoplasm KW - Transforming Growth Factor beta KW - Transforming Growth Factor beta3 KW - Index Medicus KW - RNA, Neoplasm -- biosynthesis KW - Parity KW - Animals KW - Inflammation -- physiopathology KW - Cicatrix -- physiopathology KW - Apoptosis -- physiology KW - Humans KW - Prognosis KW - Disease Progression KW - Mice KW - Protein Isoforms -- physiology KW - Wound Healing -- physiology KW - RNA, Messenger -- biosynthesis KW - Pregnancy KW - Gene Expression Profiling KW - Pregnancy Complications, Neoplastic -- physiopathology KW - Treatment Outcome KW - Transforming Growth Factor beta3 -- physiology KW - Female KW - Breast Neoplasms -- genetics KW - Lactation -- physiology KW - Transforming Growth Factor beta -- physiology KW - Breast Neoplasms -- pathology KW - Mammary Glands, Animal -- physiology KW - Transforming Growth Factor beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67346733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+mammary+gland+biology+and+neoplasia&rft.atitle=Transforming+growth+factor-%28beta%29s+and+mammary+gland+involution%3B+functional+roles+and+implications+for+cancer+progression.&rft.au=Flanders%2C+Kathleen+C%3BWakefield%2C+Lalage+M&rft.aulast=Flanders&rft.aufirst=Kathleen&rft.date=2009-06-01&rft.volume=14&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Journal+of+mammary+gland+biology+and+neoplasia&rft.issn=1573-7039&rft_id=info:doi/10.1007%2Fs10911-009-9122-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-16 N1 - Date created - 2009-06-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2008 Nov 15;68(22):9107-11 [19010878] Cell Res. 2009 Jan;19(1):128-39 [19114990] J Cell Physiol. 2009 Apr;219(1):57-68 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Apr;4(2):153-64 [10426394] Genes Dev. 1999 Oct 1;13(19):2604-16 [10521404] Exp Dermatol. 1999 Oct;8(5):407-12 [10536968] J Biol Chem. 1999 Nov 5;274(45):32145-52 [10542250] Microbes Infect. 1999 Dec;1(15):1327-47 [10611761] Invest Ophthalmol Vis Sci. 2000 Mar;41(3):756-63 [10711691] J Cell Sci. 2003 Jan 15;116(Pt 2):217-24 [12482908] J Surg Oncol. 2003 Jan;82(1):57-64 [12501169] J Biol Chem. 2003 Jan 24;278(4):2750-7 [12429738] Genet Epidemiol. 2003 Apr;24(3):230-9 [12652527] Invest Ophthalmol Vis Sci. 2003 May;44(5):2094-102 [12714648] J Biol Chem. 2003 May 16;278(20):18408-18 [12626500] Mol Cell Endocrinol. 2003 May 30;203(1-2):185-96 [12782414] Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8621-3 [12861075] Am J Pathol. 2003 Oct;163(4):1539-49 [14507660] Lab Invest. 2004 Feb;84(2):203-12 [14661032] Mol Endocrinol. 2004 May;18(5):1171-84 [14963111] Int J Exp Pathol. 2004 Apr;85(2):47-64 [15154911] Obstet Gynecol. 2004 Jul;104(1):146-54 [15229014] Curr Cancer Drug Targets. 2004 Sep;4(6):521-9 [15379637] Mol Carcinog. 2004 Dec;41(4):207-20 [15468292] Proc Natl Acad Sci U S A. 1985 Dec;82(24):8530-4 [3001708] Proc Natl Acad Sci U S A. 1986 Jun;83(12):4167-71 [2424019] J Exp Med. 1987 Jan 1;165(1):251-6 [3491869] Proc Natl Acad Sci U S A. 1987 Aug;84(16):5788-92 [2886992] Proc Natl Acad Sci U S A. 1988 Feb;85(4):1105-8 [3422482] J Biol Chem. 1988 Jun 5;263(16):7741-6 [3259578] Cancer Res. 1989 Nov 15;49(22):6419-24 [2553256] Mol Cell Biol. 1989 Dec;9(12):5508-15 [2586525] Kidney Int. 1990 Feb;37(2):689-95 [2407884] Lab Invest. 1990 Sep;63(3):307-19 [2395327] Dev Biol. 1990 Oct;141(2):456-60 [1698672] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10911-009-9122-z ER - TY - JOUR T1 - Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors. AN - 67337567; 19505917 AB - There is some evidence that oxidative stress plays a role in lead-induced toxicity. Mechanisms for dealing with oxidative stress may be of particular relevance in the brain given the high rate of oxygen metabolism. Using a hospital-based case-control study, we investigated the role of oxidative stress in the potential carcinogenicity of lead through examination of effect modification of the association between occupational lead exposure and brain tumors by single nucleotide polymorphisms in genes with functions related to oxidative stress. The study included 362 patients with glioma (176 of which had glioblastoma multiforme), 134 patients with meningioma, and 494 controls. Lead exposure was estimated by expert review of detailed job history data for each participant. We evaluated effect modification with 142 single nucleotide polymorphisms using likelihood ratio tests that compared nested unconditional logistic regression models that did and did not include a cross-product term for cumulative lead exposure and genotype. When the analyses were restricted to cases with glioblastoma multiforme, RAC2 rs2239774 and two highly correlated GPX1 polymorphisms (rs1050450 and rs18006688) were found to significantly modify the association with lead exposure (P A, STOP; and two deletions (c.525_526delAG and c.1646delC) in the CHM gene and their phenotypic effect. To analyze the effect of mutations, the 3D structure of human REP-1 and the proteins associated with REP-1 function were modeled using sequence homology with rat proteins. In silico analysis of the missense mutation L550P suggests that the proline residue at position 550 destabilizes the beta -structural elements, and the REP-1 tertiary structure. Truncation and deletion mutants are associated with a partial or total loss of the REP-1 essential activity and protein-protein interactions as predicted by the analysis of the structure and stability of these protein products. The presumptive loss of protein was confirmed by Western Blot analysis of protein from mononuclear cells and fibroblasts (FB) from CHM patients. JF - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis AU - Sergeev, Y V AU - Smaoui, N AU - Sui, R AU - Stiles, D AU - Gordiyenko, N AU - Strunnikova, N AU - MacDonald, I M AD - National Eye Institute, National Institutes of Health, Bethesda, MD, United States, macdonaldi@mail.nih.gov Y1 - 2009/06/01/ PY - 2009 DA - 2009 Jun 01 SP - 44 EP - 50 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 665 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Western blotting KW - Leukocytes (mononuclear) KW - Molecular modelling KW - Proline KW - Missense mutation KW - Deletion mutant KW - Heredity KW - Retina KW - X chromosome KW - Blindness KW - Fibroblasts KW - Mutagenesis KW - Rab protein KW - Protein structure KW - retinal pigment epithelium KW - Gene deletion KW - Homology KW - Degeneration KW - Atrophy KW - Tertiary structure KW - Protein interaction KW - X 24310:Pharmaceuticals KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20579791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.atitle=The+functional+effect+of+pathogenic+mutations+in+Rab+escort+protein+1&rft.au=Sergeev%2C+Y+V%3BSmaoui%2C+N%3BSui%2C+R%3BStiles%2C+D%3BGordiyenko%2C+N%3BStrunnikova%2C+N%3BMacDonald%2C+I+M&rft.aulast=Sergeev&rft.aufirst=Y&rft.date=2009-06-01&rft.volume=665&rft.issue=1-2&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrfmmm.2009.02.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Leukocytes (mononuclear); Western blotting; Missense mutation; Proline; Deletion mutant; Retina; Heredity; X chromosome; Blindness; Mutagenesis; Fibroblasts; Protein structure; Rab protein; retinal pigment epithelium; Gene deletion; Homology; Atrophy; Degeneration; Tertiary structure; Protein interaction DO - http://dx.doi.org/10.1016/j.mrfmmm.2009.02.015 ER - TY - JOUR T1 - NH sub(4) super(+), NO sub(3) super(-), and SO sub(4) super(2) super(-) in roadside and rural size-resolved particles and transformation of NO sub(2)/SO sub(2) to nanoparticle-bound NO sub(3) super(-)/SO sub(4) super(2) super(-) AN - 20565733; 9264601 AB - This study investigates ammonium, nitrate, and sulfate (NH sub(4) super(+), NO sub(3) super(-), and SO sub(4) super(2) super(-)) in size-resolved particles (particularly nano (PM sub(0) sub(.) sub(0) sub(1) sub(-) sub(0) sub(.) sub(0) sub(5) sub(6))/ultrafine (PM sub(0) sub(.) sub(0) sub(1) sub(-) sub(0) sub(.) sub(1))) and NO sub(x)/SO sub(2) collected near a busy road and at a rural site. The average (mass) cumulative fraction of secondary inorganic aerosols (SO sub(4) super(2) super(-)+NO sub(3) super(-)+NH sub(4) super(+)) in nano or ultrafine particles at the roadside was found to be three to four times that at the rural site. The above three secondary inorganic aerosol species were present in similar cumulative fractions in particles of size 1-18 km at both sites; however, dissimilar fractions were observed for Cl super(-), Na super(+), and K super(+). The nitrogen ratios (NRs: NR = NO sub(3) super(-)-N/(NO sub(3) super(-)-N + NO sub(2)-N)), sulfur ratios (SRs: SR = SO sub(4) super(2) super(-)-S/(SO sub(4) super(2) super(-)-S + SO sub(2)-S)), dNR/D sub(P) (derivative of NR with respect to D sub(P) (particle diameter)), and dSR/D sub(P) (derivative of SR with respect to D sub(P)) at the roadside were higher than those at the rural site for nano /ultrafine particles. At both sites (particularly the roadside), the nanoparticles had significantly higher dNR/D sub(P) and dSR/D sub(P) values than differently sized particles, implying that NO sub(3) super(-) /SO sub(4) super(2) super(-) (from NO sub(2)/SO sub(2) transformation or NO sub(3) super(-) /SO sub(4) super(2) super(-) deposition) were present on these particles. JF - Atmospheric Environment AU - Lin, C C AU - Huang, K L AU - Chen, S J AU - Liu, S C AU - Tsai, J H AU - Lin, Y C AU - Lin, W Y AD - National Pingtung University of Science and Technology, Nei Pu, 1 Hseuh Fu RD, PingTung 91201, Taiwan, chensj@mail.npust.edu.tw Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 2731 EP - 2736 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 43 IS - 17 SN - 1352-2310, 1352-2310 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Particle size KW - Sulfur KW - Sulfates KW - Aerosols KW - Sulfur in aerosols KW - roadsides KW - Particulates KW - Nanoparticles KW - Pollutant deposition KW - Sulfur dioxide KW - Sulfur particles KW - Rural areas KW - Nitrogen KW - ammonium nitrate KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20565733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=NH+sub%284%29+super%28%2B%29%2C+NO+sub%283%29+super%28-%29%2C+and+SO+sub%284%29+super%282%29+super%28-%29+in+roadside+and+rural+size-resolved+particles+and+transformation+of+NO+sub%282%29%2FSO+sub%282%29+to+nanoparticle-bound+NO+sub%283%29+super%28-%29%2FSO+sub%284%29+super%282%29+super%28-%29&rft.au=Lin%2C+C+C%3BHuang%2C+K+L%3BChen%2C+S+J%3BLiu%2C+S+C%3BTsai%2C+J+H%3BLin%2C+Y+C%3BLin%2C+W+Y&rft.aulast=Lin&rft.aufirst=C&rft.date=2009-06-01&rft.volume=43&rft.issue=17&rft.spage=2731&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2009.02.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Sulfur in aerosols; Sulfur particles; Nanoparticles; Sulfates; Sulfur; Particle size; Pollutant deposition; Aerosols; Sulfur dioxide; roadsides; Particulates; ammonium nitrate; Nitrogen; Rural areas DO - http://dx.doi.org/10.1016/j.atmosenv.2009.02.058 ER - TY - JOUR T1 - Preclinical Evaluation of an Anti-CD25 Monoclonal Antibody, 7G7/B6, Armed with the beta -Emitter, Yttrium-90, as a Radioimmunotherapeutic Agent for Treating Lymphoma AN - 20235177; 10324234 AB - Objective:Radioirnmunotherapy of cancer with radiolabeled antibodies has shown promise. We evaluated an anti-CD25 monoclonal Antibody, 7G7/B6, armed with super(90)Y as a potential radioimmunotherapeutic agent for CD25-expressing lymphomas. Materials and Methods: The lymphoma model was established by subcutaneous injection of lxlO super(7) SUDHL-1 cells into nude mice. The biodistribution of super(111)In-7G7/B6 and therapeutic studies with super(90)Y-7G7/B6 were performed in the tumor-bearing mice. Results: Therapy using super(90)Y-7G7/B6 prolonged survival of the SUDHL-1 lymphoma-bearing mice significantly, as compared with either untreated mice or the mice treated with super(9O)Y-11F11, a radiolabeled isotype-matched control antibody (p < 0.001). All of the mice in the control and the super(9O)Y-11F11 treatment groups died by days 18 and 24, respectively. In contrast, 30% of the mice in the low-dose group (75 mu Ci of super(90)Y-7G7/B6/mouse) and 75% in the high-dose group (150 mu Ci of super(90)Y-7G7/B6/mouse) became tumor free and remained healthy for greater than 6 months. Conclusions: Our findings suggested that super(90)Y-7G7/B6 is a potentially useful radioimmunotherapeutic agent for the treatment of patients with CD25-expressing lymphomas. JF - Cancer Biotherapy and Radiopharmaceuticals AU - Zhang, M AU - Yao, Z AU - Garmestani, K AU - Yu, S AU - Goldman, C K AU - Paik, CH AU - Brechbiel, M W AU - Carrasquillo, JA AU - Waldmann, T A AD - Metabolism Branch, NCI, NIH; Building 10, Room 4N115, 10 Center Drive, Bethesda, MD 20892-1374; USA, tawald@helix.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 303 EP - 309 VL - 24 IS - 3 SN - 1084-9785, 1084-9785 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Monoclonal antibodies KW - Animal models KW - Radioisotopes KW - Pharmaceuticals KW - Tumors KW - CD25 antigen KW - Lymphoma KW - Cancer KW - W 30910:Imaging KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20235177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Biotherapy+and+Radiopharmaceuticals&rft.atitle=Preclinical+Evaluation+of+an+Anti-CD25+Monoclonal+Antibody%2C+7G7%2FB6%2C+Armed+with+the+beta+-Emitter%2C+Yttrium-90%2C+as+a+Radioimmunotherapeutic+Agent+for+Treating+Lymphoma&rft.au=Zhang%2C+M%3BYao%2C+Z%3BGarmestani%2C+K%3BYu%2C+S%3BGoldman%2C+C+K%3BPaik%2C+CH%3BBrechbiel%2C+M+W%3BCarrasquillo%2C+JA%3BWaldmann%2C+T+A&rft.aulast=Zhang&rft.aufirst=M&rft.date=2009-06-01&rft.volume=24&rft.issue=3&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Cancer+Biotherapy+and+Radiopharmaceuticals&rft.issn=10849785&rft_id=info:doi/10.1089%2Fcbr.2008.0577 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Monoclonal antibodies; Radioisotopes; Animal models; Pharmaceuticals; Tumors; CD25 antigen; Lymphoma; Cancer DO - http://dx.doi.org/10.1089/cbr.2008.0577 ER - TY - JOUR T1 - Ionising radiation and cancer risks: What have we learned from epidemiology? AN - 20211653; 10311479 AB - Purpose: Epidemiologic studies of persons exposed to ionising radiation offer a wealth of information on cancer risks in humans. The Life Span Study cohort of Japanese A-bomb survivors, a large cohort that includes all ages and both sexes with a wide range of well-characterised doses, is the primary resource for estimating carcinogenic risks from low linear energy transfer external exposure. Extensive data on persons exposed for therapeutic or diagnostic medical reasons offer the opportunity to study fractionated exposure, risks at high therapeutic doses, and risks of site-specific cancers in non-Japanese populations. Studies of persons exposed for occupational and environmental reasons allow a direct evaluation of exposure at low doses and dose rates, and also provide information on different types of radiation such as radon and iodine-131. This article summarises the findings from these studies with emphasis on studies with well-characterised doses. Conclusions: Epidemiologic studies provide the necessary data for quantifying cancer risks as a function of dose and for setting radiation protection standards. Leukaemia and most solid cancers have been linked with radiation. Most solid cancer data are reasonably well described by linear-dose response functions although there may be a downturn in risks at very high doses. Persons exposed early in life have especially high relative risks for many cancers, and radiation-related risk of solid cancers appears to persist throughout life. JF - International Journal of Radiation Biology AU - Gilbert, Ethel AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 467 EP - 482 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 85 IS - 6 SN - 0955-3002, 0955-3002 KW - Toxicology Abstracts KW - Risk assessment KW - Age KW - Data processing KW - Life span KW - Cancer KW - Radon KW - Leukemia KW - Radiation KW - Epidemiology KW - Risk factors KW - Occupational exposure KW - Sex KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20211653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Biology&rft.atitle=Ionising+radiation+and+cancer+risks%3A+What+have+we+learned+from+epidemiology%3F&rft.au=Gilbert%2C+Ethel&rft.aulast=Gilbert&rft.aufirst=Ethel&rft.date=2009-06-01&rft.volume=85&rft.issue=6&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Biology&rft.issn=09553002&rft_id=info:doi/10.1080%2F09553000902883836 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Leukemia; Age; Data processing; Epidemiology; Radiation; Risk factors; Life span; Radon; Occupational exposure; Cancer; Sex DO - http://dx.doi.org/10.1080/09553000902883836 ER - TY - JOUR T1 - Noncoding Mutations of HGF Are Associated with Nonsyndromic Hearing Loss, DFNB39 AN - 20141101; 10258625 AB - A gene causing autosomal-recessive, nonsyndromic hearing loss, DFNB39, was previously mapped to an 18 Mb interval on chromosome 7q11.22-q21.12. We mapped an additional 40 consanguineous families segregating nonsyndromic hearing loss to the DFNB39 locus and refined the obligate interval to 1.2 Mb. The coding regions of all genes in this interval were sequenced, and no missense, nonsense, or frameshift mutations were found. We sequenced the noncoding sequences of genes, as well as noncoding genes, and found three mutations clustered in intron 4 and exon 5 in the hepatocyte growth factor gene (HGF). Two intron 4 deletions occur in a highly conserved sequence that is part of the 3' untranslated region of a previously undescribed short isoform of HGF. The third mutation is a silent substitution, and we demonstrate that it affects splicing in vitro. HGF is involved in a wide variety of signaling pathways in many different tissues, yet these putative regulatory mutations cause a surprisingly specific phenotype, which is nonsydromic hearing loss. Two mouse models of Hgf dysregulation, one in which an Hgf transgene is ubiquitously overexpressed and the other a conditional knockout that deletes Hgf from a limited number of tissues, including the cochlea, result in deafness. Overexpression of HGF is associated with progressive degeneration of outer hair cells in the cochlea, whereas cochlear deletion of Hgf is associated with more general dysplasia. JF - American Journal of Human Genetics AU - Schultz, Julie M AU - Khan, Shaheen N AU - Ahmed, Zubair M AU - Riazuddin, Saima AU - Waryah, Ali M AU - Chhatre, Dhananjay AU - Starost, Matthew F AU - Ploplis, Barbara AU - Buckley, Stephanie AU - Velasquez, David AU - Kabra, Madhulika AU - Lee, Kwanghyuk AU - Hassan, Muhammad J AU - Ali, Ghazanfar AU - Ansar, Muhammad AU - Ghosh, Manju AU - Wilcox, Edward R AU - Ahmad, Wasim AU - Merlino, Glenn AU - Leal, Suzanne M AU - Riazuddin, Sheikh AU - Friedman, Thomas B AU - Morell, Robert J AD - Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA, morellr@nidcd.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 25 EP - 39 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 84 IS - 6 SN - 0002-9297, 0002-9297 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Genetics Abstracts KW - Cochlea KW - Dysplasia KW - Exons KW - Transgenes KW - Animal models KW - Hearing loss KW - chromosome 7 KW - outer hair cells KW - Splicing KW - Deafness KW - Frameshift mutation KW - Introns KW - Conserved sequence KW - Degeneration KW - Hepatocyte growth factor KW - Signal transduction KW - N3 11023:Neurogenetics KW - G 07870:Mammals KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20141101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Human+Genetics&rft.atitle=Noncoding+Mutations+of+HGF+Are+Associated+with+Nonsyndromic+Hearing+Loss%2C+DFNB39&rft.au=Schultz%2C+Julie+M%3BKhan%2C+Shaheen+N%3BAhmed%2C+Zubair+M%3BRiazuddin%2C+Saima%3BWaryah%2C+Ali+M%3BChhatre%2C+Dhananjay%3BStarost%2C+Matthew+F%3BPloplis%2C+Barbara%3BBuckley%2C+Stephanie%3BVelasquez%2C+David%3BKabra%2C+Madhulika%3BLee%2C+Kwanghyuk%3BHassan%2C+Muhammad+J%3BAli%2C+Ghazanfar%3BAnsar%2C+Muhammad%3BGhosh%2C+Manju%3BWilcox%2C+Edward+R%3BAhmad%2C+Wasim%3BMerlino%2C+Glenn%3BLeal%2C+Suzanne+M%3BRiazuddin%2C+Sheikh%3BFriedman%2C+Thomas+B%3BMorell%2C+Robert+J&rft.aulast=Schultz&rft.aufirst=Julie&rft.date=2009-06-01&rft.volume=84&rft.issue=6&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Human+Genetics&rft.issn=00029297&rft_id=info:doi/10.1016%2Fj.ajhg.2009.06.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Cochlea; Dysplasia; Exons; Transgenes; Animal models; Hearing loss; chromosome 7; Deafness; Splicing; outer hair cells; Frameshift mutation; Introns; Conserved sequence; Degeneration; Hepatocyte growth factor; Signal transduction DO - http://dx.doi.org/10.1016/j.ajhg.2009.06.003 ER - TY - JOUR T1 - Structure of a multidrug transporter AN - 20135614; 10082189 JF - Nature Biotechnology AU - Gottesman, Michael M AU - Ambudkar, Suresh V AU - Xia, Di AD - Michael M. Gottesman, Suresh V. Ambudkar and Di Xia are at the Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., mgottesman@nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 546 EP - 547 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 27 IS - 6 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Drugs KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20135614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Structure+of+a+multidrug+transporter&rft.au=Gottesman%2C+Michael+M%3BAmbudkar%2C+Suresh+V%3BXia%2C+Di&rft.aulast=Gottesman&rft.aufirst=Michael&rft.date=2009-06-01&rft.volume=27&rft.issue=6&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt0609-546 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein structure; Drugs DO - http://dx.doi.org/10.1038/nbt0609-546 ER - TY - JOUR T1 - Accounting for nonspecific enhancement in neuronal tract tracing using manganese enhanced magnetic resonance imaging AN - 20123904; 10254629 AB - Manganese enhanced MRI (MEMRI) is an emerging technique for tracing neuronal pathways in vivo. However, manganese may leak into blood vessels or cerebrospinal fluid (CSF) after local injection and can be circulated to and taken up by brain regions that may not have connections to the targeted pathways. Comparing enhancement time courses after intranasal injection with intravenous infusion of MnCl sub(2) in rats, the early enhancements in the pituitary gland (Pit) and hippocampus indicate the contrasts in those regions in the olfactory tract-tracing experiment were caused by such systemic effects. Since the Pit has easy access to manganese from the blood and its signal is proportional to other brain regions after intravenous infusion, it was used as an internal reference for the systemic effects. Applying intensity normalization by the Pit signal to tract-tracing data from the olfactory bulb led to reduced contrast in the hippocampus. These results demonstrate that nonspecific enhancements in MEMRI tract-tracing studies may have to be taken into account and that normalization by the Pit signal can compensate these effects. JF - Magnetic Resonance Imaging AU - Chuang, Kai-Hsiang AU - Koretsky, Alan P AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, chuangk@ninds.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 594 EP - 600 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 27 IS - 5 SN - 0730-725X, 0730-725X KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Intravenous administration KW - Data processing KW - Hippocampus KW - Magnetic resonance imaging KW - Brain KW - Olfactory bulb KW - Cerebrospinal fluid KW - Blood vessels KW - Pituitary KW - Manganese KW - W 30910:Imaging KW - N3 11009:Neuroendocrinology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20123904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Accounting+for+nonspecific+enhancement+in+neuronal+tract+tracing+using+manganese+enhanced+magnetic+resonance+imaging&rft.au=Chuang%2C+Kai-Hsiang%3BKoretsky%2C+Alan+P&rft.aulast=Chuang&rft.aufirst=Kai-Hsiang&rft.date=2009-06-01&rft.volume=27&rft.issue=5&rft.spage=594&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2008.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Manganese; Magnetic resonance imaging; Hippocampus; Intravenous administration; Brain; Cerebrospinal fluid; Data processing; Blood vessels; Pituitary; Olfactory bulb DO - http://dx.doi.org/10.1016/j.mri.2008.10.006 ER - TY - JOUR T1 - Glioma Stem Cells: Better Flat Than Round AN - 20074430; 10131838 AB - Glioma-initiating cells/glioma stem cells (GIC/GSCs) are grown invitro using a cumbersome and inefficient spheroid assay. In this issue of Cell Stem Cell, Pollard and coworkers present a protocol for the efficient derivation of GIC/GSC lines that may greatly improve the isolation and the potential clinical application of these cells JF - Cell Stem Cell AU - Woolard, Kevin AU - Fine, Howard A AD - Neuro-Oncology Branch, National Cancer Institute, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, hfine@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 466 EP - 467 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 4 IS - 6 SN - 1934-5909, 1934-5909 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Stem cells KW - Glioma cells KW - Therapeutic applications KW - spheroids KW - W 30965:Miscellaneous, Reviews KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20074430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Stem+Cell&rft.atitle=Glioma+Stem+Cells%3A+Better+Flat+Than+Round&rft.au=Woolard%2C+Kevin%3BFine%2C+Howard+A&rft.aulast=Woolard&rft.aufirst=Kevin&rft.date=2009-06-01&rft.volume=4&rft.issue=6&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Cell+Stem+Cell&rft.issn=19345909&rft_id=info:doi/10.1016%2Fj.stem.2009.05.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Stem cells; Glioma cells; Therapeutic applications; spheroids DO - http://dx.doi.org/10.1016/j.stem.2009.05.013 ER - TY - JOUR T1 - Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase AN - 20073008; 10082885 AB - To probe Pol functions in vivo via its error signature, here we report the properties of Saccharomyces cerevisiae Pol in which phenyalanine was substituted for the conserved Leu-979 in the catalytic (Rev3) subunit. We show that purified L979F Pol is 30% as active as wild-type Pol when replicating undamaged DNA. L979F Pol shares with wild-type Pol the ability to perform moderately processive DNA synthesis. When copying undamaged DNA, L979F Pol is error-prone compared to wild-type Pol , providing a biochemical rationale for the observed mutator phenotype of rev3-L979F yeast strains. Errors generated by L979F Pol in vitro include single-base insertions, deletions and substitutions, with the highest error rates involving stable misincorporation of dAMP and dGMP. L979F Pol also generates multiple errors in close proximity to each other. The frequency of these events far exceeds that expected for independent single changes, indicating that the first error increases the probability of additional errors within 10 nucleotides. Thus L979F Pol , and perhaps wild-type Pol , which also generates clustered mutations at a lower but significant rate, performs short patches of processive, error-prone DNA synthesis. This may explain the origin of some multiple clustered mutations observed in vivo. JF - Nucleic Acids Research AU - Stone, Jana E AU - Kissling, Grace E AU - Lujan, Scott A AU - Rogozin, Igor B AU - Stith, Carrie M AU - Burgers, Peter MJ AU - Kunkel, Thomas A Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 3774 EP - 3787 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 37 IS - 11 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids KW - DNA biosynthesis KW - Gene deletion KW - DNA-directed DNA polymerase KW - Probes KW - Mutation KW - Nucleotides KW - Saccharomyces cerevisiae KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20073008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Low-fidelity+DNA+synthesis+by+the+L979F+mutator+derivative+of+Saccharomyces+cerevisiae+DNA+polymerase&rft.au=Stone%2C+Jana+E%3BKissling%2C+Grace+E%3BLujan%2C+Scott+A%3BRogozin%2C+Igor+B%3BStith%2C+Carrie+M%3BBurgers%2C+Peter+MJ%3BKunkel%2C+Thomas+A&rft.aulast=Stone&rft.aufirst=Jana&rft.date=2009-06-01&rft.volume=37&rft.issue=11&rft.spage=3774&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkp238 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Gene deletion; DNA-directed DNA polymerase; Probes; Mutation; Nucleotides; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1093/nar/gkp238 ER - TY - JOUR T1 - Monitoring Compound Integrity With Cytochrome P450 Assays and qHTS AN - 20072546; 10083620 AB - The authors describe how room temperature storage of a 1120-member compound library prepared in either DMSO or in a hydrated-DMSO/water (67/33) mixture affects the reproducibility of potency values as monitored using cytochrome P450 1A2 and 2D6 isozyme assays. The bioluminescent assays showed Za[EuroA super(2) factors of 0.71 and 0.62, with 17% and 32% of the library found as active against the CYP 1A2 and 2D6 isozymes, respectively. The authors tested the library using quantitative high-throughput screening to generate potency values for every library member, which was measured at 7 time intervals spanning 37 weeks. They calculated the minimum significant ratio (MSR) from these potency values at each time interval and found that for the library stored in DMSO, the CYP 1A2 and 2D6 assay MSRs progressed from approximately 2.0 to 5.0. The hydrated conditions showed similar performance in both MSR progression and analytical quality control results. Based on this study, the authors recommend that DMSO samples be stored in 1536-well plates for <4 months at room temperature. Furthermore, the study illustrates the degree and time scale of apparent compound potency changes due to sample storage. (Journal of Biomolecular Screening 2009:538-546 JF - Journal of Biomolecular Screening AU - MacArthur, Ryan AU - Leister, William AU - Veith, Henrike AU - Shinn, Paul AU - Southall, Noel AU - Austin, Christopher P AU - Inglese, James AU - Auld, Douglas S AD - NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892-3370, USA, dauld@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 538 EP - 546 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 14 IS - 5 SN - 1087-0571, 1087-0571 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Quality control KW - Isoenzymes KW - high-throughput screening KW - Cytochrome P450 KW - Water temperature KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20072546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Monitoring+Compound+Integrity+With+Cytochrome+P450+Assays+and+qHTS&rft.au=MacArthur%2C+Ryan%3BLeister%2C+William%3BVeith%2C+Henrike%3BShinn%2C+Paul%3BSouthall%2C+Noel%3BAustin%2C+Christopher+P%3BInglese%2C+James%3BAuld%2C+Douglas+S&rft.aulast=MacArthur&rft.aufirst=Ryan&rft.date=2009-06-01&rft.volume=14&rft.issue=5&rft.spage=538&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057109336954 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Temperature effects; Quality control; Isoenzymes; high-throughput screening; Water temperature; Cytochrome P450 DO - http://dx.doi.org/10.1177/1087057109336954 ER - TY - JOUR T1 - Cardiac sympathetic neuroimaging: summary of the First International Symposium AN - 20072209; 10080337 AB - The First International Symposium on Cardiac Sympathetic Neuroimaging brought together for the first time clinical and preclinical researchers evaluating autonomic and neurocardiologic disorders by this modality. The invited lectures and posters presented some uses of cardiac sympathetic neuroimaging for diagnosis, prognosis, and monitoring treatments. The Symposium also included a discussion about whether and how to expand the availability of cardiac sympathetic neuroimaging at medical centers in the United States. Here, we review the background for the Symposium, provide an annotated summary of the lectures and posters, discuss some of the take-home points from the roundtable discussion, and propose a plan of action for the future. JF - Clinical Autonomic Research AU - Goldstein, David S AU - Orimo, Satoshi Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 137 EP - 148 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 19 IS - 3 SN - 0959-9851, 0959-9851 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Heart KW - Neuroimaging KW - Autonomic nervous system KW - Reviews KW - Prognosis KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20072209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Autonomic+Research&rft.atitle=Cardiac+sympathetic+neuroimaging%3A+summary+of+the+First+International+Symposium&rft.au=Goldstein%2C+David+S%3BOrimo%2C+Satoshi&rft.aulast=Goldstein&rft.aufirst=David&rft.date=2009-06-01&rft.volume=19&rft.issue=3&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Clinical+Autonomic+Research&rft.issn=09599851&rft_id=info:doi/10.1007%2Fs10286-009-0002-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Neuroimaging; Autonomic nervous system; Reviews; Prognosis DO - http://dx.doi.org/10.1007/s10286-009-0002-9 ER - TY - JOUR T1 - Bone marrow, thymus and blood: changes across the lifespan AN - 1014108835; 16481630 AB - The aim of this review is to present age-related changes in the bone marrow and thymus and their effects in later life. Age-related hematologic changes are marked by a decline in marrow cellularity, an increased risk of myeloproliferative disorders and anemia, and a decline in adaptive immunity. The exact mechanisms that produce these changes remain undefined. For the most part, the changes in function that are a consequence of aging alone rarely have meaningful clinical consequences. However, in the face of the stresses induced by other illnesses, the decreased physiologic reserve can slow or prevent an appropriate response to the stressors. JF - Aging Health AU - Prabhakar, Mamatha AU - Ershler, William B AU - Longo, Dan L AD - Clinical Research Branch, National Institute on Aging, and, Medstar Research Institute, Harbor Hospital, 3001 South Hanover Street, Baltimore, MD 21225, USA., prabhakarm@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 385 EP - 393 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 5 IS - 3 SN - 1745-509X, 1745-509X KW - Risk Abstracts KW - anemia KW - Reviews KW - Bone marrow KW - Stress KW - aging KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1014108835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+Health&rft.atitle=Bone+marrow%2C+thymus+and+blood%3A+changes+across+the+lifespan&rft.au=Prabhakar%2C+Mamatha%3BErshler%2C+William+B%3BLongo%2C+Dan+L&rft.aulast=Prabhakar&rft.aufirst=Mamatha&rft.date=2009-06-01&rft.volume=5&rft.issue=3&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Aging+Health&rft.issn=1745509X&rft_id=info:doi/10.2217%2Fahe.09.31 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Number of references - 95 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - anemia; Reviews; Bone marrow; Stress; aging DO - http://dx.doi.org/10.2217/ahe.09.31 ER - TY - CPAPER T1 - Regulation of Protein Phosphorylation at the Postsynaptic Density: Global Analysis Targeting Specific Kinase and Phosphatase Activities T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40378702; 5282426 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Jaffe, Howard AU - Dosemeci, Ayse Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Postsynaptic density KW - Phosphorylation KW - Phosphatase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40378702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Regulation+of+Protein+Phosphorylation+at+the+Postsynaptic+Density%3A+Global+Analysis+Targeting+Specific+Kinase+and+Phosphatase+Activities&rft.au=Jaffe%2C+Howard%3BDosemeci%2C+Ayse&rft.aulast=Jaffe&rft.aufirst=Howard&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Teaching the Masses. Development of a Mass Spectrometry Tutorial for the Biomedical Researcher T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40377578; 5280796 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Kelley, James AU - Blonder, Josip AU - Sumpter, Terry AU - Veenstra, Timothy AU - Phillips, Lawrence Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Education KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40377578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Teaching+the+Masses.+Development+of+a+Mass+Spectrometry+Tutorial+for+the+Biomedical+Researcher&rft.au=Kelley%2C+James%3BBlonder%2C+Josip%3BSumpter%2C+Terry%3BVeenstra%2C+Timothy%3BPhillips%2C+Lawrence&rft.aulast=Kelley&rft.aufirst=James&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autoantigen Structural Studies: Photolytic Oxidation and Chemical Modification Combined With Mass Spectrometry T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40376671; 5282465 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Wang, Jinglan AU - Smedley III, James AU - Bilski, Piotr AU - Kuhn, Jeffrey AU - Tomer, Kenneth AU - Deterding, Leesa Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Oxidation KW - Chemical modification KW - Autoantigens KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40376671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Autoantigen+Structural+Studies%3A+Photolytic+Oxidation+and+Chemical+Modification+Combined+With+Mass+Spectrometry&rft.au=Wang%2C+Jinglan%3BSmedley+III%2C+James%3BBilski%2C+Piotr%3BKuhn%2C+Jeffrey%3BTomer%2C+Kenneth%3BDeterding%2C+Leesa&rft.aulast=Wang&rft.aufirst=Jinglan&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterizing the ATP-Induced Structural Changes of the N-terminal Domain of Pms1 by Oxidative Surface Mapping and Mass Spectrometry Schorzman T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40372224; 5282464 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Schorzman, Allison AU - Perera, Lalith AU - Pedersen, Lars AU - Cutalo, Jenny AU - Darden, Thomas AU - Kunkel, Thomas AU - Tomer, Kenneth Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Mapping KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40372224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Characterizing+the+ATP-Induced+Structural+Changes+of+the+N-terminal+Domain+of+Pms1+by+Oxidative+Surface+Mapping+and+Mass+Spectrometry+Schorzman&rft.au=Schorzman%2C+Allison%3BPerera%2C+Lalith%3BPedersen%2C+Lars%3BCutalo%2C+Jenny%3BDarden%2C+Thomas%3BKunkel%2C+Thomas%3BTomer%2C+Kenneth&rft.aulast=Schorzman&rft.aufirst=Allison&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Corona Discharge Initiated Electrochemical Ionization T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40369748; 5282018 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Lloyd, John AU - Hess, Sonja Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Electrochemistry KW - Ionization KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40369748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Corona+Discharge+Initiated+Electrochemical+Ionization&rft.au=Lloyd%2C+John%3BHess%2C+Sonja&rft.aulast=Lloyd&rft.aufirst=John&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Methylation of dihydrotestosterone and implications for quantitative analysis T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40368175; 5281090 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Lih, Fred AU - Titus, Mark AU - Mohler, James AU - Tomer, Kenneth Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Quantitative analysis KW - Dihydrotestosterone KW - Methylation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40368175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Methylation+of+dihydrotestosterone+and+implications+for+quantitative+analysis&rft.au=Lih%2C+Fred%3BTitus%2C+Mark%3BMohler%2C+James%3BTomer%2C+Kenneth&rft.aulast=Lih&rft.aufirst=Fred&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing Phosphatidylserine Metabolism by Mass Spectrometry T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40367314; 5281011 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Kimura, Atsuko AU - Kevala, Karl AU - Kim, Hee-yong Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Metabolism KW - Phosphatidylserine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40367314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Probing+Phosphatidylserine+Metabolism+by+Mass+Spectrometry&rft.au=Kimura%2C+Atsuko%3BKevala%2C+Karl%3BKim%2C+Hee-yong&rft.aulast=Kimura&rft.aufirst=Atsuko&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Mass Spectrometry to Characterize a Novel Ptm in the Escherichia Coli Ribosomal Protein s12 T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40366239; 5282968 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Strader, Michael AU - Fujigaki, Suwako AU - Chen, Cai AU - Costantino, Nina AU - Makusky, Anthony AU - Hervy IV, W AU - Court, Donald AU - Markey, Sanford AU - Kowalak, Jeffrey Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Ribosomal protein S12 KW - Escherichia coli KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40366239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Using+Mass+Spectrometry+to+Characterize+a+Novel+Ptm+in+the+Escherichia+Coli+Ribosomal+Protein+s12&rft.au=Strader%2C+Michael%3BFujigaki%2C+Suwako%3BChen%2C+Cai%3BCostantino%2C+Nina%3BMakusky%2C+Anthony%3BHervy+IV%2C+W%3BCourt%2C+Donald%3BMarkey%2C+Sanford%3BKowalak%2C+Jeffrey&rft.aulast=Strader&rft.aufirst=Michael&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid, Isotope-Coded Method for Mapping Protein-Protein and Protein-Ligand Interactions T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40365799; 5283156 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Johnson, Katina AU - Cuneo, Matthew AU - London, Robert AU - Tomer, Kenneth AU - Williams, Jason Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mapping KW - Peptide mapping KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40365799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Rapid%2C+Isotope-Coded+Method+for+Mapping+Protein-Protein+and+Protein-Ligand+Interactions&rft.au=Johnson%2C+Katina%3BCuneo%2C+Matthew%3BLondon%2C+Robert%3BTomer%2C+Kenneth%3BWilliams%2C+Jason&rft.aulast=Johnson&rft.aufirst=Katina&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Profiling Akt-Interacting Proteins in Neuronal Cells T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40364536; 5283161 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Huang, Bill AU - Kim, Hee-yong Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40364536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Profiling+Akt-Interacting+Proteins+in+Neuronal+Cells&rft.au=Huang%2C+Bill%3BKim%2C+Hee-yong&rft.aulast=Huang&rft.aufirst=Bill&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluating the Antigenicity of Cancer Therapeutic Immunotoxins Using MS-Based Epitope Mapping T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40364069; 5281159 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Smedley, James AU - Hansen, Johanna AU - Onda, Masanori AU - Pastan, Ira AU - Tomer, Kenneth Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Cancer KW - Epitope mapping KW - Immunotoxins KW - Antigenicity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40364069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Evaluating+the+Antigenicity+of+Cancer+Therapeutic+Immunotoxins+Using+MS-Based+Epitope+Mapping&rft.au=Smedley%2C+James%3BHansen%2C+Johanna%3BOnda%2C+Masanori%3BPastan%2C+Ira%3BTomer%2C+Kenneth&rft.aulast=Smedley&rft.aufirst=James&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fragmentation pathways of non-tryptic peptides: formation of the bn-1+OH ion T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40363997; 5281762 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Perdivara, Irina AU - Deterding, Leesa AU - Przybylski, Michael AU - Tomer, Kenneth Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Peptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40363997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Fragmentation+pathways+of+non-tryptic+peptides%3A+formation+of+the+bn-1%2BOH+ion&rft.au=Perdivara%2C+Irina%3BDeterding%2C+Leesa%3BPrzybylski%2C+Michael%3BTomer%2C+Kenneth&rft.aulast=Perdivara&rft.aufirst=Irina&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a Novel Amine Derivatization to Investigate the Structural Properties of Proteins by Mass Spectrometry T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40363398; 5283217 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Paul, Lake AU - Tomer, Kenneth Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Amines KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40363398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Characterization+of+a+Novel+Amine+Derivatization+to+Investigate+the+Structural+Properties+of+Proteins+by+Mass+Spectrometry&rft.au=Paul%2C+Lake%3BTomer%2C+Kenneth&rft.aulast=Paul&rft.aufirst=Lake&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of N-Acylphosphatidylethanolamines by LC-MS/MS T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40362239; 5281012 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Kevala, Karl AU - Kim, Jeff AU - Lee, Jeongrim AU - Kim, Hee-yong Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40362239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Analysis+of+N-Acylphosphatidylethanolamines+by+LC-MS%2FMS&rft.au=Kevala%2C+Karl%3BKim%2C+Jeff%3BLee%2C+Jeongrim%3BKim%2C+Hee-yong&rft.aulast=Kevala&rft.aufirst=Karl&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Low Can We Go? An Evaluation of Strategies for Small-Molecule Analysis by Maldi T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40362019; 5282847 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Lai, Christopher AU - Phillips, Lawrence AU - Smith, Lyndsay AU - Kelley, James Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40362019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=How+Low+Can+We+Go%3F+An+Evaluation+of+Strategies+for+Small-Molecule+Analysis+by+Maldi&rft.au=Lai%2C+Christopher%3BPhillips%2C+Lawrence%3BSmith%2C+Lyndsay%3BKelley%2C+James&rft.aulast=Lai&rft.aufirst=Christopher&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Metabolite Search Using Stable Isotope Labeled Docosahexaenoic Acid Coupled to HPLC/MS/MS T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40361691; 5281961 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Lee, Jeongrim AU - Kevala, Karl AU - Kim, Hee-yong Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Isotopes KW - Metabolites KW - Docosahexaenoic acid KW - High-performance liquid chromatography KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40361691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Novel+Metabolite+Search+Using+Stable+Isotope+Labeled+Docosahexaenoic+Acid+Coupled+to+HPLC%2FMS%2FMS&rft.au=Lee%2C+Jeongrim%3BKevala%2C+Karl%3BKim%2C+Hee-yong&rft.aulast=Lee&rft.aufirst=Jeongrim&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasma Pharmacokinetics of NSC 265959, a Novel 3,11-Diazasteroid, in Mice T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40361385; 5281818 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Phillips, Lawrence AU - Carter, John AU - Majerova, Eva AU - Newton, Dianne AU - Hollingshead, Melinda Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mice KW - Pharmacokinetics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40361385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Plasma+Pharmacokinetics+of+NSC+265959%2C+a+Novel+3%2C11-Diazasteroid%2C+in+Mice&rft.au=Phillips%2C+Lawrence%3BCarter%2C+John%3BMajerova%2C+Eva%3BNewton%2C+Dianne%3BHollingshead%2C+Melinda&rft.aulast=Phillips&rft.aufirst=Lawrence&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved Sensitivity in Mass Spectrometric Quantification of Cardiolipin in Human Serum by HPLC/ESI-MS T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40361137; 5282289 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Ogbonna, Elizabeth AU - Kim, Hee-Yong AU - Yergey, Alfred AU - Backlund, Peter Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Sensitivity KW - Cardiolipin KW - High-performance liquid chromatography KW - Serum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40361137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Improved+Sensitivity+in+Mass+Spectrometric+Quantification+of+Cardiolipin+in+Human+Serum+by+HPLC%2FESI-MS&rft.au=Ogbonna%2C+Elizabeth%3BKim%2C+Hee-Yong%3BYergey%2C+Alfred%3BBacklund%2C+Peter&rft.aulast=Ogbonna&rft.aufirst=Elizabeth&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of an on-bead digestion procedure for immunoprecipitated proteins T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40359527; 5281753 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Berberich, Matthew AU - Nanavati, Dhaval AU - Makusky, Anthony AU - Martin, Brian AU - Vullhorst, Detlef AU - Buonanno, Andres AU - Markey, Sanford Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Digestion KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Development+of+an+on-bead+digestion+procedure+for+immunoprecipitated+proteins&rft.au=Berberich%2C+Matthew%3BNanavati%2C+Dhaval%3BMakusky%2C+Anthony%3BMartin%2C+Brian%3BVullhorst%2C+Detlef%3BBuonanno%2C+Andres%3BMarkey%2C+Sanford&rft.aulast=Berberich&rft.aufirst=Matthew&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mood Stabilizer-Induced Changes in the Postsynaptic Density Proteome T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40355862; 5281794 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Nanavati, Dhaval AU - Catapano, Lisa AU - Makusky, Anthony AU - Dosemeci, Ayse AU - Austin, Daniel AU - Chen, Guang AU - Manji, Husseini AU - Markey, Sanford Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mood KW - Postsynaptic density KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Mood+Stabilizer-Induced+Changes+in+the+Postsynaptic+Density+Proteome&rft.au=Nanavati%2C+Dhaval%3BCatapano%2C+Lisa%3BMakusky%2C+Anthony%3BDosemeci%2C+Ayse%3BAustin%2C+Daniel%3BChen%2C+Guang%3BManji%2C+Husseini%3BMarkey%2C+Sanford&rft.aulast=Nanavati&rft.aufirst=Dhaval&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Squid Neuron Analysis: Applying Proteomic Software Tools to LC/MS/MS Data from Species without Annotated Genomes T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40355096; 5282181 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Makusky, Anthony AU - DeGiorgis, Joseph AU - Kowalak, Jeffrey AU - Markey, Sanford Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Computer programs KW - Genomes KW - Data processing KW - Proteomics KW - Software KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Squid+Neuron+Analysis%3A+Applying+Proteomic+Software+Tools+to+LC%2FMS%2FMS+Data+from+Species+without+Annotated+Genomes&rft.au=Makusky%2C+Anthony%3BDeGiorgis%2C+Joseph%3BKowalak%2C+Jeffrey%3BMarkey%2C+Sanford&rft.aulast=Makusky&rft.aufirst=Anthony&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determining the Compatibility Between Processing and Staining Methods for Histological Analysis of Frozen Tissue Specimens and LC-MS Analysis of Hormones T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40351540; 5280576 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Hanson, Jeffrey AU - Johann, Donald AU - Rodriguez-Canales, Jaime AU - Xu, Xia AU - Blonder, Josip AU - Emmert-Buck, Michael AU - Veenstra, Timothy Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Hormones KW - Staining KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Determining+the+Compatibility+Between+Processing+and+Staining+Methods+for+Histological+Analysis+of+Frozen+Tissue+Specimens+and+LC-MS+Analysis+of+Hormones&rft.au=Hanson%2C+Jeffrey%3BJohann%2C+Donald%3BRodriguez-Canales%2C+Jaime%3BXu%2C+Xia%3BBlonder%2C+Josip%3BEmmert-Buck%2C+Michael%3BVeenstra%2C+Timothy&rft.aulast=Hanson&rft.aufirst=Jeffrey&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor. AN - 67291139; 19332542 AB - We investigated the role of G protein-coupled receptor kinase (GRK)-mediated phosphorylation in agonist-induced desensitization, arrestin association, endocytosis, and intracellular trafficking of the D(2) dopamine receptor (DAR). Agonist activation of D(2) DARs results in rapid and sustained receptor phosphorylation that is solely mediated by GRKs. A survey of GRKs revealed that only GRK2 or GRK3 promotes D(2) DAR phosphorylation. Mutational analyses resulted in the identification of eight serine/threonine residues within the third cytoplasmic loop of the receptor that are phosphorylated by GRK2/3. Simultaneous mutation of these eight residues results in a receptor construct, GRK(-), that is completely devoid of agonist-promoted GRK-mediated receptor phosphorylation. We found that both wild-type (WT) and GRK(-) receptors underwent a similar degree of agonist-induced desensitization as assessed using [(35)S]GTPgammaS binding assays. Similarly, both receptor constructs internalized to the same extent in response to agonist treatment. Furthermore, using bioluminescence resonance energy transfer assays to directly assess receptor association with arrestin3, we found no differences between the WT and GRK(-) receptors. Thus, phosphorylation is not required for arrestin-receptor association or agonist-induced desensitization or internalization. In contrast, when we examined recycling of the D(2) DARs to the cell surface, subsequent to agonist-induced endocytosis, the GRK(-) construct exhibited less recycling in comparison with the WT receptor. This impairment appears to be due to a greater propensity of the GRK(-) receptors to down-regulate once internalized. In contrast, if the receptor is highly phosphorylated, then receptor recycling is promoted. These results reveal a novel role for GRK-mediated phosphorylation in regulating the post-endocytic trafficking of a G protein-coupled receptor. JF - The Journal of biological chemistry AU - Namkung, Yoon AU - Dipace, Concetta AU - Javitch, Jonathan A AU - Sibley, David R AD - Molecular Neuropharmacology Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892-9405, USA. Y1 - 2009/05/29/ PY - 2009 DA - 2009 May 29 SP - 15038 EP - 15051 VL - 284 IS - 22 SN - 0021-9258, 0021-9258 KW - Arrestins KW - 0 KW - Receptors, Dopamine D2 KW - arrestin3 KW - Protein Kinase C KW - EC 2.7.11.13 KW - G-Protein-Coupled Receptor Kinases KW - EC 2.7.11.16 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Dopamine -- pharmacology KW - Protein Transport -- drug effects KW - Humans KW - Fluorescence Resonance Energy Transfer KW - Amino Acid Sequence KW - Phosphorylation -- drug effects KW - Rats KW - Protein Kinase C -- metabolism KW - Mutagenesis, Site-Directed KW - Genes, Dominant KW - Molecular Sequence Data KW - Mutation -- genetics KW - Arrestins -- metabolism KW - Cell Line KW - G-Protein-Coupled Receptor Kinases -- metabolism KW - Receptors, Dopamine D2 -- chemistry KW - Receptors, Dopamine D2 -- agonists KW - Endocytosis -- drug effects KW - Receptors, Dopamine D2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67291139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=G+protein-coupled+receptor+kinase-mediated+phosphorylation+regulates+post-endocytic+trafficking+of+the+D2+dopamine+receptor.&rft.au=Namkung%2C+Yoon%3BDipace%2C+Concetta%3BJavitch%2C+Jonathan+A%3BSibley%2C+David+R&rft.aulast=Namkung&rft.aufirst=Yoon&rft.date=2009-05-29&rft.volume=284&rft.issue=22&rft.spage=15038&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M900388200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-29 N1 - Date created - 2009-05-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 1996 Mar;49(3):560-6 [8643097] Mol Pharmacol. 1994 May;45(5):878-89 [7910658] Mol Pharmacol. 1996 Oct;50(4):966-76 [8863843] Can J Physiol Pharmacol. 1996 Oct;74(10):1095-110 [9022829] Physiol Rev. 1998 Jan;78(1):189-225 [9457173] Annu Rev Biochem. 1998;67:653-92 [9759500] J Cell Biol. 1999 Jan 11;144(1):31-43 [9885242] Eur J Biochem. 1999 Feb;260(1):112-9 [10091590] Eur J Biochem. 1999 Jul;263(2):596-602 [10406971] J Recept Signal Transduct Res. 2004 Aug;24(3):165-205 [15521361] J Biol Chem. 2004 Nov 19;279(47):49533-41 [15347675] Mol Pharmacol. 2004 Dec;66(6):1635-42 [15361545] J Biol Chem. 2005 Jan 21;280(3):2197-204 [15542600] Pharmacol Ther. 2005 Jun;106(3):405-21 [15922020] EMBO J. 2005 Jul 6;24(13):2265-83 [15944737] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11521-6 [16049099] J Biol Chem. 2006 Feb 3;281(5):2932-8 [16319069] Mol Pharmacol. 2006 Mar;69(3):759-69 [16338988] Mol Pharmacol. 2006 Mar;69(3):673-6 [16339846] Pharmacol Ther. 2006 Jun;110(3):465-502 [16460808] Protein Eng Des Sel. 2006 Sep;19(9):391-400 [16857694] Biochem Biophys Res Commun. 2006 Nov 24;350(3):634-40 [17022946] Annu Rev Physiol. 2007;69:451-82 [17037978] Annu Rev Physiol. 2007;69:483-510 [17305471] Annu Rev Physiol. 2007;69:511-34 [17305472] Trends Pharmacol Sci. 2007 Apr;28(4):173-9 [17350109] Synapse. 2007 Dec;61(12):1013-8 [17853435] J Biol Chem. 2007 Oct 5;282(40):29178-85 [17635908] Eur J Pharmacol. 2007 Dec 22;577(1-3):44-53 [17869243] Annu Rev Pharmacol Toxicol. 2008;48:601-29 [17995450] Annu Rev Pharmacol Toxicol. 2008;48:537-68 [18184106] Schizophr Res. 2008 Mar;100(1-3):4-19 [18291627] Neuropharmacology. 2008 Jun;54(8):1215-22 [18455202] J Neurochem. 2008 Jul;106(1):83-95 [18346199] Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9988-93 [18621717] Mol Endocrinol. 2008 Aug;22(8):1881-92 [18550774] J Recept Signal Transduct Res. 2008;28(5):453-64 [18946766] Mol Pharmacol. 2009 Jan;75(1):113-23 [18809670] Mol Pharmacol. 2009 Jan;75(1):19-26 [18820126] Synapse. 2009 Jul;63(7):621-4 [19309759] Pharmacol Rev. 2001 Mar;53(1):1-24 [11171937] J Biol Chem. 2001 Oct 5;276(40):37409-14 [11473130] Biol Psychiatry. 2001 Dec 1;50(11):873-83 [11743942] J Biol Chem. 2002 May 17;277(20):17916-27 [11867621] Science. 2002 Jul 26;297(5581):615-20 [12142540] Neuron. 2003 Apr 24;38(2):291-303 [12718862] Cell Signal. 2004 Apr;16(4):497-503 [14709338] J Biol Chem. 2004 Jun 11;279(24):25590-7 [15084596] Annu Rev Neurosci. 2004;27:107-44 [15217328] J Biochem. 1988 Mar;103(3):436-41 [3391998] Mol Pharmacol. 1991 Jan;39(1):55-63 [1846220] Mol Pharmacol. 1991 May;39(5):650-8 [1674585] Trends Pharmacol Sci. 1992 Feb;13(2):61-9 [1561715] Br J Pharmacol. 1996 Jul;118(6):1544-50 [8832084] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M900388200 ER - TY - CPAPER T1 - Analysis of phase I pharmacokinetic studies with targeted molecules based on gender and age T2 - 45th Annual Meeting of the American Society of Clinical Oncology (ASCO 2009) AN - 40216387; 5195795 JF - 45th Annual Meeting of the American Society of Clinical Oncology (ASCO 2009) AU - Di Segni, S. AU - Sperduti, I AU - Cinquina, A AU - Contestabile, M AU - Nuvoli, B AU - Giannarelli, D AU - Cognetti, F AU - Gelibter, A Y1 - 2009/05/29/ PY - 2009 DA - 2009 May 29 KW - Sex KW - Pharmacokinetics KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40216387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2009%29&rft.atitle=Analysis+of+phase+I+pharmacokinetic+studies+with+targeted+molecules+based+on+gender+and+age&rft.au=Di+Segni%2C+S.%3BSperduti%2C+I%3BCinquina%2C+A%3BContestabile%2C+M%3BNuvoli%2C+B%3BGiannarelli%2C+D%3BCognetti%2C+F%3BGelibter%2C+A&rft.aulast=Di+Segni&rft.aufirst=S.&rft.date=2009-05-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_meeting_cat egories_view&confID=65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dose-escalating study of continuative low dose of oral vinorelbine in patients with advanced breast cancer T2 - 45th Annual Meeting of the American Society of Clinical Oncology (ASCO 2009) AN - 40215612; 5195546 JF - 45th Annual Meeting of the American Society of Clinical Oncology (ASCO 2009) AU - Felici, A AU - Russillo, M AU - Di Segni, S. AU - Fabi, A AU - Ferretti, G AU - Carlini, P AU - Contestabile, M AU - Nuvoli, B AU - Sperduti, I AU - Cognetti, F AU - Papaldo, P Y1 - 2009/05/29/ PY - 2009 DA - 2009 May 29 KW - Breast cancer KW - Vinorelbine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40215612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2009%29&rft.atitle=Dose-escalating+study+of+continuative+low+dose+of+oral+vinorelbine+in+patients+with+advanced+breast+cancer&rft.au=Felici%2C+A%3BRussillo%2C+M%3BDi+Segni%2C+S.%3BFabi%2C+A%3BFerretti%2C+G%3BCarlini%2C+P%3BContestabile%2C+M%3BNuvoli%2C+B%3BSperduti%2C+I%3BCognetti%2C+F%3BPapaldo%2C+P&rft.aulast=Felici&rft.aufirst=A&rft.date=2009-05-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstract.asco.org/absttogo.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Value of stable disease (SD) in drug development of targeted therapies (TGT) T2 - 45th Annual Meeting of the American Society of Clinical Oncology (ASCO 2009) AN - 40214398; 5195765 JF - 45th Annual Meeting of the American Society of Clinical Oncology (ASCO 2009) AU - Vidaurre, T AU - Wilkerson, J AU - Bates, S AU - Simon, R AU - Fojo, A Y1 - 2009/05/29/ PY - 2009 DA - 2009 May 29 KW - Drug development KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40214398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2009%29&rft.atitle=Value+of+stable+disease+%28SD%29+in+drug+development+of+targeted+therapies+%28TGT%29&rft.au=Vidaurre%2C+T%3BWilkerson%2C+J%3BBates%2C+S%3BSimon%2C+R%3BFojo%2C+A&rft.aulast=Vidaurre&rft.aufirst=T&rft.date=2009-05-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_meeting_cat egories_view&confID=65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A phase I study of nelfinavir, an FDA approved HIV protease inhibitor, in adults with refractory solid tumors T2 - 45th Annual Meeting of the American Society of Clinical Oncology (ASCO 2009) AN - 40211440; 5195825 JF - 45th Annual Meeting of the American Society of Clinical Oncology (ASCO 2009) AU - Dennis, P AU - Blumenthal, G AU - Ballas, M AU - Gardner, E AU - Kawabata, S AU - LoPiccolo, J AU - Helsabeck, C AU - Root, H AU - Figg, W AU - Bernstein, W Y1 - 2009/05/29/ PY - 2009 DA - 2009 May 29 KW - Proteinase inhibitors KW - Human immunodeficiency virus KW - Tumors KW - FDA KW - Nelfinavir KW - Solid tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40211440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2009%29&rft.atitle=A+phase+I+study+of+nelfinavir%2C+an+FDA+approved+HIV+protease+inhibitor%2C+in+adults+with+refractory+solid+tumors&rft.au=Dennis%2C+P%3BBlumenthal%2C+G%3BBallas%2C+M%3BGardner%2C+E%3BKawabata%2C+S%3BLoPiccolo%2C+J%3BHelsabeck%2C+C%3BRoot%2C+H%3BFigg%2C+W%3BBernstein%2C+W&rft.aulast=Dennis&rft.aufirst=P&rft.date=2009-05-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_meeting_cat egories_view&confID=65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The UICC Cervical Cancer Initiative: A comprehensive program for cervical cancer prevention worldwide including a fellowship program T2 - 45th Annual Meeting of the American Society of Clinical Oncology (ASCO 2009) AN - 40209031; 5195598 JF - 45th Annual Meeting of the American Society of Clinical Oncology (ASCO 2009) AU - Harford, J Y1 - 2009/05/29/ PY - 2009 DA - 2009 May 29 KW - Cervical cancer KW - Prevention KW - Fellowships KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40209031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2009%29&rft.atitle=The+UICC+Cervical+Cancer+Initiative%3A+A+comprehensive+program+for+cervical+cancer+prevention+worldwide+including+a+fellowship+program&rft.au=Harford%2C+J&rft.aulast=Harford&rft.aufirst=J&rft.date=2009-05-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_meeting_cat egories_view&confID=65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure. AN - 67267840; 19402631 AB - Homology modeling of the human A(2A) adenosine receptor (AR) based on bovine rhodopsin predicted a protein structure that was very similar to the recently determined crystallographic structure. The discrepancy between the experimentally observed orientation of the antagonist and those obtained by previous antagonist docking is related to the loop structure of rhodopsin being carried over to the model of the A(2A) AR and was rectified when the beta(2)-adrenergic receptor was used as a template for homology modeling. Docking of the triazolotriazine antagonist ligand ZM241385 1 was greatly improved by including water molecules of the X-ray structure or by using a constraint from mutagenesis. Automatic agonists docking to both a new homology modeled receptor and the A(2A) AR crystallographic structure produced similar results. Heterocyclic nitrogen atoms closely corresponded when the docked adenine moiety of agonists and 1 were overlaid. The cumulative mutagenesis data, which support the proposed mode of agonist docking, can be reexamined in light of the crystallographic structure. Thus, homology modeling of GPCRs remains a useful technique in probing the structure of the protein and predicting modes of ligand docking. JF - Journal of medicinal chemistry AU - Ivanov, Andrei A AU - Barak, Dov AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/05/28/ PY - 2009 DA - 2009 May 28 SP - 3284 EP - 3292 VL - 52 IS - 10 KW - Adenosine A2 Receptor Agonists KW - 0 KW - Adenosine A2 Receptor Antagonists KW - Receptor, Adenosine A2A KW - Receptors, G-Protein-Coupled KW - Rhodopsin KW - 9009-81-8 KW - Index Medicus KW - Animals KW - Cattle KW - Rhodopsin -- antagonists & inhibitors KW - Rhodopsin -- agonists KW - Humans KW - Crystallography, X-Ray KW - Sequence Homology, Amino Acid KW - Rhodopsin -- chemistry KW - Protein Binding KW - Protein Conformation KW - Mutagenesis KW - Receptors, G-Protein-Coupled -- antagonists & inhibitors KW - Receptor, Adenosine A2A -- chemistry KW - Computer Simulation KW - Receptors, G-Protein-Coupled -- agonists KW - Models, Molecular KW - Receptors, G-Protein-Coupled -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67267840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Evaluation+of+homology+modeling+of+G-protein-coupled+receptors+in+light+of+the+A%282A%29+adenosine+receptor+crystallographic+structure.&rft.au=Ivanov%2C+Andrei+A%3BBarak%2C+Dov%3BJacobson%2C+Kenneth+A&rft.aulast=Ivanov&rft.aufirst=Andrei&rft.date=2009-05-28&rft.volume=52&rft.issue=10&rft.spage=3284&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm801533x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-17 N1 - Date created - 2009-05-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2008 Jul 24;454(7203):486-91 [18594507] Curr Pharm Des. 2008;14(15):1525-52 [18537675] Science. 2008 Nov 21;322(5905):1211-7 [18832607] Trends Pharmacol Sci. 2008 Dec;29(12):616-25 [18838178] J Comput Chem. 2009 Jan 15;30(1):14-32 [18496794] Science. 2000 Aug 4;289(5480):739-45 [10926528] J Med Chem. 2001 Nov 22;44(24):4125-36 [11708915] Annu Rev Pharmacol Toxicol. 2002;42:437-67 [11807179] J Med Chem. 2003 Nov 6;46(23):4847-59 [14584936] Bioorg Med Chem. 2004 May 1;12(9):2021-34 [15080906] J Mol Biol. 2004 Sep 10;342(2):571-83 [15327956] FEBS Lett. 1985 May 6;184(1):30-5 [2985445] Proc Natl Acad Sci U S A. 1989 Sep;86(17):6572-6 [2771944] J Med Chem. 1990 Jun;33(6):1708-13 [2342066] J Med Chem. 1990 Dec;33(12):3127-30 [2258897] J Biol Chem. 1995 Jun 9;270(23):13987-97 [7775460] Br J Pharmacol. 1995 Jul;115(6):1096-102 [7582508] Mol Pharmacol. 1996 Apr;49(4):683-91 [8609897] Mol Pharmacol. 1996 Sep;50(3):512-21 [8794889] Eur J Pharmacol. 1996 Aug 29;310(2-3):269-72 [8884226] J Med Chem. 1997 Aug 1;40(16):2588-95 [9258366] Bioorg Med Chem. 1998 May;6(5):523-33 [9629466] Biochemistry. 1999 Mar 23;38(12):3498-507 [10090736] Chem Biol. 2005 Feb;12(2):237-47 [15734651] J Med Chem. 2006 Jan 26;49(2):534-53 [16420040] Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1507-17 [16438031] Nat Rev Drug Discov. 2006 Mar;5(3):247-64 [16518376] J Mol Graph Model. 2007 Jan;25(5):740-54 [17095272] Biochemistry. 2007 Jun 26;46(25):7437-48 [17542617] Nature. 2007 Nov 15;450(7168):383-7 [17952055] Chem Rev. 2008 Jan;108(1):238-63 [18181659] J Chem Inf Model. 2008 Feb;48(2):350-63 [18215030] J Med Chem. 2008 Apr 10;51(7):2088-99 [18321038] J Med Chem. 2008 May 22;51(10):2907-14 [18442228] Bioorg Med Chem. 2008 Sep 15;16(18):8546-56 [18752961] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm801533x ER - TY - JOUR T1 - Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. AN - 67267177; 19397322 AB - We have recently identified a new class of compounds that selectively kill cells that express P-glycoprotein (P-gp, MDR1), the ATPase efflux pump that confers multidrug resistance on cancer cells. Several isatin-beta-thiosemicarbazones from our initial study have been validated and a range of analogues synthesized and tested. A number demonstrated improved MDR1-selective activity over the lead, NSC73306 (1). Pharmacophores for cytotoxicity and MDR1 selectivity were generated to delineate the structural features required for activity. The MDR1-selective pharmacophore highlights the importance of aromatic/hydrophobic features at the N4 position of the thiosemicarbazone and the reliance on the isatin moiety as key bioisosteric contributors. Additionally, a quantitative structure-activity relationship (QSAR) model that yielded a cross-validated correlation coefficient of 0.85 effectively predicts the cytotoxicity of untested thiosemicarbazones. Together, the models serve as effective approaches for predicting structures with MDR1-selective activity and aid in directing the search for the mechanism of action of 1. JF - Journal of medicinal chemistry AU - Hall, Matthew D AU - Salam, Noeris K AU - Hellawell, Jennifer L AU - Fales, Henry M AU - Kensler, Caroline B AU - Ludwig, Joseph A AU - Szakács, Gergely AU - Hibbs, David E AU - Gottesman, Michael M AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/05/28/ PY - 2009 DA - 2009 May 28 SP - 3191 EP - 3204 VL - 52 IS - 10 KW - Cytotoxins KW - 0 KW - Enzyme Inhibitors KW - Indoles KW - NSC73306 KW - P-Glycoprotein KW - isatin beta-thiosemicarbazone KW - 487-16-1 KW - Isatin KW - 82X95S7M06 KW - Index Medicus KW - Hydrophobic and Hydrophilic Interactions KW - Quantitative Structure-Activity Relationship KW - HeLa Cells KW - Humans KW - Indoles -- pharmacology KW - Enzyme Inhibitors -- chemical synthesis KW - Substrate Specificity KW - Cell Death -- drug effects KW - P-Glycoprotein -- antagonists & inhibitors KW - Isatin -- pharmacology KW - Isatin -- chemical synthesis KW - Isatin -- chemistry KW - Drug Resistance, Multiple -- drug effects KW - Cytotoxins -- pharmacology KW - Isatin -- analogs & derivatives KW - Cytotoxins -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67267177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Synthesis%2C+activity%2C+and+pharmacophore+development+for+isatin-beta-thiosemicarbazones+with+selective+activity+toward+multidrug-resistant+cells.&rft.au=Hall%2C+Matthew+D%3BSalam%2C+Noeris+K%3BHellawell%2C+Jennifer+L%3BFales%2C+Henry+M%3BKensler%2C+Caroline+B%3BLudwig%2C+Joseph+A%3BSzak%C3%A1cs%2C+Gergely%3BHibbs%2C+David+E%3BGottesman%2C+Michael+M&rft.aulast=Hall&rft.aufirst=Matthew&rft.date=2009-05-28&rft.volume=52&rft.issue=10&rft.spage=3191&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm800861c LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-17 N1 - Date created - 2009-05-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] Annu Rev Med. 2002;53:615-27 [11818492] Eur J Med Chem. 2002 Nov;37(11):909-18 [12446050] Curr Opin Investig Drugs. 2002 Nov;3(11):1652-9 [12476969] J Med Chem. 2003 Mar 27;46(7):1116-9 [12646019] Chem Biol. 2003 Dec;10(12):1255-66 [14700633] Mini Rev Med Chem. 2004 Jan;4(1):31-9 [14754441] Cancer Cell. 2004 Aug;6(2):129-37 [15324696] Cancer Chemother Pharmacol. 2004 Oct;54(4):331-42 [15148626] Proc Natl Acad Sci U S A. 1973 Jan;70(1):164-8 [4119222] Mol Pharmacol. 1977 Jan;13(1):89-98 [834188] Bioinorg Chem. 1977;7(2):151-7 [861291] J Med Chem. 1979 Jul;22(7):855-62 [376848] Prog Med Chem. 1978;15:321-56 [400614] Br Med Bull. 1985 Oct;41(4):309-14 [2996681] J Biol Chem. 1986 Jun 15;261(17):7762-70 [3711108] Free Radic Res. 1994 Feb;20(2):83-101 [8012526] Prog Med Chem. 1995;32:1-35 [8577916] Biochem Pharmacol. 1997 Sep 15;54(6):649-55 [9310341] Anticancer Res. 1997 Sep-Oct;17(5A):3185-93 [9413147] Adv Enzyme Regul. 1999;39:3-12 [10470363] Curr Opin Drug Discov Devel. 2005 Mar;8(2):207-27 [15782545] Pharmacol Rev. 2005 Dec;57(4):547-83 [16382108] Nat Rev Drug Discov. 2006 Mar;5(3):219-34 [16518375] Nat Rev Drug Discov. 2006 Apr;5(4):279-80 [16628834] Cancer Res. 2006 May 1;66(9):4808-15 [16651436] Bioorg Med Chem. 2006 Sep 15;14(18):6434-43 [16759872] Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6 [17003122] Adv Drug Deliv Rev. 2006 Nov 30;58(12-13):1431-50 [17097188] Bioorg Med Chem. 2007 Jan 15;15(2):931-8 [17088067] J Comput Aided Mol Des. 2006 Oct-Nov;20(10-11):647-71 [17124629] J Clin Oncol. 2007 Mar 1;25(7):884-96 [17327610] Expert Rev Anticancer Ther. 2007 Apr;7(4):447-59 [17428165] Leuk Res. 2003 Dec;27(12):1077-83 [12921943] Cancer Res. 2000 Aug 1;60(15):4152-60 [10945623] Arch Pharm (Weinheim). 2002 Aug;335(8):374-80 [12397621] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm800861c ER - TY - JOUR T1 - Topographical and Temporal Diversity of the Human Skin Microbiome AN - 20621082; 9350436 AB - Human skin is a large, heterogeneous organ that protects the body from pathogens while sustaining microorganisms that influence human health and disease. Our analysis of 16S ribosomal RNA gene sequences obtained from 20 distinct skin sites of healthy humans revealed that physiologically comparable sites harbor similar bacterial communities. The complexity and stability of the microbial community are dependent on the specific characteristics of the skin site. This topographical and temporal survey provides a baseline for studies that examine the role of bacterial communities in disease states and the microbial interdependencies required to maintain healthy skin. JF - Science (Washington) AU - Grice, Elizabeth A AU - Kong, Heidi H AU - Conlan, Sean AU - Deming, Clayton B AU - Davis, Joie AU - Young, Alice C AU - NISC Comparative Sequencing Program, AU - Bouffard, Gerard G AU - Blakesley, Robert W AU - Murray, Patrick R AU - Green, Eric D AU - Turner, Maria L AU - Segre, Julia A AD - Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA., jsegre@nhgri.nih.gov Y1 - 2009/05/28/ PY - 2009 DA - 2009 May 28 SP - 1190 EP - 1192 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 324 IS - 5931 SN - 0036-8075, 0036-8075 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Ecology Abstracts KW - Skin KW - Microorganisms KW - Pathogens KW - rRNA 16S KW - A 01490:Miscellaneous KW - D 04040:Ecosystem and Ecology Studies KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20621082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Topographical+and+Temporal+Diversity+of+the+Human+Skin+Microbiome&rft.au=Grice%2C+Elizabeth+A%3BKong%2C+Heidi+H%3BConlan%2C+Sean%3BDeming%2C+Clayton+B%3BDavis%2C+Joie%3BYoung%2C+Alice+C%3BNISC+Comparative+Sequencing+Program%2C%3BBouffard%2C+Gerard+G%3BBlakesley%2C+Robert+W%3BMurray%2C+Patrick+R%3BGreen%2C+Eric+D%3BTurner%2C+Maria+L%3BSegre%2C+Julia+A&rft.aulast=Grice&rft.aufirst=Elizabeth&rft.date=2009-05-28&rft.volume=324&rft.issue=5931&rft.spage=1190&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1171700 L2 - http://www.sciencemag.org/cgi/reprint/324/5931/1190.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Skin; Microorganisms; Pathogens; rRNA 16S DO - http://dx.doi.org/10.1126/science.1171700 ER - TY - JOUR T1 - Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. AN - 67317845; 19492085 AB - PTEN-induced novel kinase 1 (PINK1) mutations are associated with autosomal recessive parkinsonism. Previous studies have shown that PINK1 influences both mitochondrial function and morphology although it is not clearly established which of these are primary events and which are secondary. Here, we describe a novel mechanism linking mitochondrial dysfunction and alterations in mitochondrial morphology related to PINK1. Cell lines were generated by stably transducing human dopaminergic M17 cells with lentiviral constructs that increased or knocked down PINK1. As in previous studies, PINK1 deficient cells have lower mitochondrial membrane potential and are more sensitive to the toxic effects of mitochondrial complex I inhibitors. We also show that wild-type PINK1, but not recessive mutant or kinase dead versions, protects against rotenone-induced mitochondrial fragmentation whereas PINK1 deficient cells show lower mitochondrial connectivity. Expression of dynamin-related protein 1 (Drp1) exaggerates PINK1 deficiency phenotypes and Drp1 RNAi rescues them. We also show that Drp1 is dephosphorylated in PINK1 deficient cells due to activation of the calcium-dependent phosphatase calcineurin. Accordingly, the calcineurin inhibitor FK506 blocks both Drp1 dephosphorylation and loss of mitochondrial integrity in PINK1 deficient cells but does not fully rescue mitochondrial membrane potential. We propose that alterations in mitochondrial connectivity in this system are secondary to functional effects on mitochondrial membrane potential. JF - PloS one AU - Sandebring, Anna AU - Thomas, Kelly Jean AU - Beilina, Alexandra AU - van der Brug, Marcel AU - Cleland, Megan M AU - Ahmad, Rili AU - Miller, David W AU - Zambrano, Ibardo AU - Cowburn, Richard F AU - Behbahani, Homira AU - Cedazo-Mínguez, Angel AU - Cookson, Mark R AD - Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America. Y1 - 2009/05/27/ PY - 2009 DA - 2009 May 27 SP - 1 VL - 4 IS - 5 KW - Microtubule-Associated Proteins KW - 0 KW - Mitochondrial Proteins KW - Rotenone KW - 03L9OT429T KW - Protein Kinases KW - EC 2.7.- KW - PTEN-induced putative kinase KW - EC 2.7.11.1 KW - Calcineurin KW - EC 3.1.3.16 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - DNM1L protein, human KW - EC 3.6.5.5 KW - Index Medicus KW - Phenotype KW - Gene Knockdown Techniques KW - Cell Survival -- drug effects KW - Humans KW - Enzyme Activation -- drug effects KW - Rotenone -- pharmacology KW - Models, Biological KW - Cell Line KW - Phosphorylation -- drug effects KW - Protein Kinases -- metabolism KW - Microtubule-Associated Proteins -- metabolism KW - Calcineurin -- metabolism KW - Protein Kinases -- deficiency KW - Mitochondria -- ultrastructure KW - Mitochondria -- enzymology KW - GTP Phosphohydrolases -- metabolism KW - Mitochondria -- drug effects KW - Mitochondrial Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67317845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Mitochondrial+alterations+in+PINK1+deficient+cells+are+influenced+by+calcineurin-dependent+dephosphorylation+of+dynamin-related+protein+1.&rft.au=Sandebring%2C+Anna%3BThomas%2C+Kelly+Jean%3BBeilina%2C+Alexandra%3Bvan+der+Brug%2C+Marcel%3BCleland%2C+Megan+M%3BAhmad%2C+Rili%3BMiller%2C+David+W%3BZambrano%2C+Ibardo%3BCowburn%2C+Richard+F%3BBehbahani%2C+Homira%3BCedazo-M%C3%ADnguez%2C+Angel%3BCookson%2C+Mark+R&rft.aulast=Sandebring&rft.aufirst=Anna&rft.date=2009-05-27&rft.volume=4&rft.issue=5&rft.spage=e5701&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0005701 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-20 N1 - Date created - 2009-06-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0005701 ER - TY - CPAPER T1 - Biospecimen Research to Enable Molecular Medicine T2 - Biomarker World Congress 2009 AN - 42130695; 5149728 JF - Biomarker World Congress 2009 AU - Moore, Helen Y1 - 2009/05/27/ PY - 2009 DA - 2009 May 27 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42130695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Biomarker+World+Congress+2009&rft.atitle=Biospecimen+Research+to+Enable+Molecular+Medicine&rft.au=Moore%2C+Helen&rft.aulast=Moore&rft.aufirst=Helen&rft.date=2009-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Biomarker+World+Congress+2009&rft.issn=&rft_id=info:doi/ L2 - http://www.the-infoshop.com/conference/biomarker-world09/catalog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Public-Private Partnerships in Driving Biomarker Development: The Biomarkers Consortium T2 - Biomarker World Congress 2009 AN - 42124583; 5149690 JF - Biomarker World Congress 2009 AU - Wholley, David Y1 - 2009/05/27/ PY - 2009 DA - 2009 May 27 KW - Bioindicators KW - Biomarkers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42124583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Biomarker+World+Congress+2009&rft.atitle=The+Role+of+Public-Private+Partnerships+in+Driving+Biomarker+Development%3A+The+Biomarkers+Consortium&rft.au=Wholley%2C+David&rft.aulast=Wholley&rft.aufirst=David&rft.date=2009-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Biomarker+World+Congress+2009&rft.issn=&rft_id=info:doi/ L2 - http://www.the-infoshop.com/conference/biomarker-world09/catalog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Environmental estrogens and obesity AN - 896214040; 15124853 AB - Many chemicals in the environment, in particular those with estrogenic activity, can disrupt the programming of endocrine signaling pathways that are established during development and result in adverse consequences that may not be apparent until much later in life. Most recently, obesity and diabetes join the growing list of adverse consequences that have been associated with developmental exposure to environmental estrogens during critical stages of differentiation. These diseases are quickly becoming significant public health issues and are fast reaching epidemic proportions worldwide. In this review, we summarize the literature from experimental animal studies documenting an association of environmental estrogens and the development of obesity, and further describe an animal model of exposure to diethylstilbestrol (DES) that has proven useful in studying mechanisms involved in abnormal programming of various differentiating estrogen-target tissues. Other examples of environmental estrogens including the phytoestrogen genistein and the environmental contaminant Bisphenol A are also discussed. Together, these data suggest new targets (i.e., adipocyte differentiation and molecular mechanisms involved in weight homeostasis) for abnormal programming by estrogenic chemicals, and provide evidence that support the scientific hypothesis termed "the developmental origins of adult disease". The proposal of an association of environmental estrogens with obesity and diabetes expands the focus on the diseases from intervention/treatment to include prevention/avoidance of chemical modifiers especially during critical windows of development. JF - Molecular and Cellular Endocrinology AU - Newbold, Retha R AU - Padilla-Banks, Elizabeth AU - Jefferson, Wendy N Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 SP - 84 EP - 89 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 304 IS - 1-2 SN - 0303-7207, 0303-7207 KW - Physical Education Index KW - Metabolic disease KW - Diabetes KW - Xenoestrogens KW - Developmental exposure KW - Endocrine disruptor KW - Bisphenol A KW - Obesity KW - Programs KW - Estrogen KW - Preventive health KW - Basic instruction program KW - Diseases KW - Adults KW - Public health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896214040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Endocrinology&rft.atitle=Environmental+estrogens+and+obesity&rft.au=Newbold%2C+Retha+R%3BPadilla-Banks%2C+Elizabeth%3BJefferson%2C+Wendy+N&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2009-05-25&rft.volume=304&rft.issue=1-2&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Endocrinology&rft.issn=03037207&rft_id=info:doi/10.1016%2Fj.mce.2009.02.024 LA - English DB - Physical Education Index N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Obesity; Programs; Preventive health; Estrogen; Basic instruction program; Adults; Diseases; Public health; Diabetes DO - http://dx.doi.org/10.1016/j.mce.2009.02.024 ER - TY - JOUR T1 - Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity. AN - 67223804; 19433253 AB - The basis for the current obesity epidemic remains controversial. However, the simplistic idea that obesity can be explained by two factors: energy intake and energy expenditure, is now being challenged due to the lack of success in decreasing obesity based on a focus on only these two factors. In this article we propose an emerging hypothesis that the recent dramatic increase in obesity could be due to developmental nutrition, developmental exposure to environmental chemicals or the interaction of nutrition and environmental chemical exposures during development. Indeed, developmental exposure to environmental chemicals in animal studies has been shown to increase the susceptibility to a number of diseases including obesity. Obesity is thus one of many diseases shown to have a developmental origin. We show that factors that impact growth during fetal and neonatal life, such as placental blood flow and nutrient transport to fetuses, as well as components of the maternal and infant diets, can influence weight gain later in life. In addition, we show that developmental exposure to endocrine disrupting chemicals can create abnormalities in homeostatic control systems required to maintain a normal body weight throughout life. Eliminating exposures to these chemicals and improving nutrition during development offer the potential for reducing obesity and associated diseases. JF - Molecular and cellular endocrinology AU - Heindel, Jerrold J AU - vom Saal, Frederick S AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences, NIH/DHHS, Cellular, Organs and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA. heindelj@niehs.nih.gov Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 SP - 90 EP - 96 VL - 304 IS - 1-2 KW - Endocrine Disruptors KW - 0 KW - Environmental Pollutants KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Infant KW - Animals KW - Humans KW - Nicotine -- adverse effects KW - Infant, Newborn KW - Diet KW - Placenta -- physiology KW - Placenta -- blood supply KW - Regional Blood Flow KW - Female KW - Pregnancy KW - Nutritional Status KW - Obesity -- etiology KW - Environmental Pollutants -- pharmacology KW - Fetus -- drug effects KW - Endocrine Disruptors -- pharmacology KW - Fetus -- physiology KW - Environmental Exposure KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67223804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Role+of+nutrition+and+environmental+endocrine+disrupting+chemicals+during+the+perinatal+period+on+the+aetiology+of+obesity.&rft.au=Heindel%2C+Jerrold+J%3Bvom+Saal%2C+Frederick+S&rft.aulast=Heindel&rft.aufirst=Jerrold&rft.date=2009-05-25&rft.volume=304&rft.issue=1-2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=1872-8057&rft_id=info:doi/10.1016%2Fj.mce.2009.02.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mce.2009.02.025 ER - TY - CPAPER T1 - How different is Neosartorya udagawae from Aspergillus fumigatus ? T2 - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AN - 42129051; 5147889 JF - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AU - Sugui, Janyce Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 KW - Insecticides KW - Aspergillus fumigatus KW - Neosartorya KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42129051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.atitle=How+different+is+Neosartorya+udagawae+from+Aspergillus+fumigatus+%3F&rft.au=Sugui%2C+Janyce&rft.aulast=Sugui&rft.aufirst=Janyce&rft.date=2009-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/isham2009/pdf/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical applicability of interpretive breakpoints and methodologies for in vitro antifungal susceptibility testing T2 - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AN - 42128533; 5147798 JF - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AU - Walsh, Thomas Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 KW - Breakpoints KW - Fungicides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42128533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.atitle=Clinical+applicability+of+interpretive+breakpoints+and+methodologies+for+in+vitro+antifungal+susceptibility+testing&rft.au=Walsh%2C+Thomas&rft.aulast=Walsh&rft.aufirst=Thomas&rft.date=2009-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/isham2009/pdf/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Invasive aspergillosis in hematological and transplant patients: Comparisons between pediatric and adult populations T2 - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AN - 42119588; 5147694 JF - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AU - Walsh, Thomas Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 KW - Hematology KW - Pediatrics KW - Aspergillosis KW - Transplants KW - Aspergillus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42119588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.atitle=Invasive+aspergillosis+in+hematological+and+transplant+patients%3A+Comparisons+between+pediatric+and+adult+populations&rft.au=Walsh%2C+Thomas&rft.aulast=Walsh&rft.aufirst=Thomas&rft.date=2009-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/isham2009/pdf/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human pharmacogenomic models for antifungal efficacy and toxicity T2 - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AN - 42116262; 5147772 JF - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AU - Walsh, Thomas Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 KW - Toxicity KW - Models KW - Pharmacogenomics KW - Fungicides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42116262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.atitle=Human+pharmacogenomic+models+for+antifungal+efficacy+and+toxicity&rft.au=Walsh%2C+Thomas&rft.aulast=Walsh&rft.aufirst=Thomas&rft.date=2009-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/isham2009/pdf/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Uncommon and emerging fungal pathogens: Clinical manifestations and therapeutic options T2 - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AN - 42115957; 5147662 JF - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AU - Walsh, Thomas Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 KW - Pathogens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42115957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.atitle=Uncommon+and+emerging+fungal+pathogens%3A+Clinical+manifestations+and+therapeutic+options&rft.au=Walsh%2C+Thomas&rft.aulast=Walsh&rft.aufirst=Thomas&rft.date=2009-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/isham2009/pdf/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recent developments in the epidemiology of infections caused by Scedosporium species T2 - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AN - 42115892; 5147635 JF - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AU - Walsh, Thomas Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 KW - Infection KW - Epidemiology KW - Scedosporium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42115892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.atitle=Recent+developments+in+the+epidemiology+of+infections+caused+by+Scedosporium+species&rft.au=Walsh%2C+Thomas&rft.aulast=Walsh&rft.aufirst=Thomas&rft.date=2009-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/isham2009/pdf/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Individual differences in voriconazole N- and C-Oxidation in vivo independent on cytochrome P450 2C19 genotypes T2 - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AN - 42115445; 5147618 JF - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AU - Bennett, John Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 KW - Cytochrome P450 KW - Genotypes KW - Voriconazole KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42115445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.atitle=Individual+differences+in+voriconazole+N-+and+C-Oxidation+in+vivo+independent+on+cytochrome+P450+2C19+genotypes&rft.au=Bennett%2C+John&rft.aulast=Bennett&rft.aufirst=John&rft.date=2009-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/isham2009/pdf/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intrinsic heteroresistance of Cryptococcus neoformans to azoles: A stress survival mechanism of the fungus T2 - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AN - 42114801; 5147587 JF - 17th Congress of The International Society for Human and Animal Mycology 2009 (ISHAM 2009) AU - Kwon-Chung, Kyung Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 KW - Stress KW - Survival KW - Azoles KW - Cryptococcus neoformans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42114801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.atitle=Intrinsic+heteroresistance+of+Cryptococcus+neoformans+to+azoles%3A+A+stress+survival+mechanism+of+the+fungus&rft.au=Kwon-Chung%2C+Kyung&rft.aulast=Kwon-Chung&rft.aufirst=Kyung&rft.date=2009-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+Congress+of+The+International+Society+for+Human+and+Animal+Mycology+2009+%28ISHAM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congre.co.jp/isham2009/pdf/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SeqA protein and the architecture of the E. coli nucleoid T2 - 2009 Gordon Research Conference on Chromosome Dynamics AN - 42149494; 5156635 JF - 2009 Gordon Research Conference on Chromosome Dynamics AU - Austin, Stuart Y1 - 2009/05/24/ PY - 2009 DA - 2009 May 24 KW - Nucleoids KW - SeqA protein KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42149494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Chromosome+Dynamics&rft.atitle=SeqA+protein+and+the+architecture+of+the+E.+coli+nucleoid&rft.au=Austin%2C+Stuart&rft.aulast=Austin&rft.aufirst=Stuart&rft.date=2009-05-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Chromosome+Dynamics&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=chromosome LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromate-free corrosion resistant nanocomposite pretreatments for light-weight metals T2 - 215th Meeting of the Electrochemical Society AN - 42140292; 5157995 JF - 215th Meeting of the Electrochemical Society AU - Liu, Jiong AU - Bafna, Shekhar AU - Allen, Fred AU - Skandan, Ganesh Y1 - 2009/05/24/ PY - 2009 DA - 2009 May 24 KW - Corrosion KW - Metals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42140292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=215th+Meeting+of+the+Electrochemical+Society&rft.atitle=Chromate-free+corrosion+resistant+nanocomposite+pretreatments+for+light-weight+metals&rft.au=Liu%2C+Jiong%3BBafna%2C+Shekhar%3BAllen%2C+Fred%3BSkandan%2C+Ganesh&rft.aulast=Liu&rft.aufirst=Jiong&rft.date=2009-05-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=215th+Meeting+of+the+Electrochemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://ecsmeet7.peerx-press.org/jsp/mas/reportSymposiumList.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. AN - 67303098; 19479063 AB - Polymorphisms in genes coding for enzymes that activate tobacco lung carcinogens may generate inter-individual differences in lung cancer risk. Previous studies had limited sample sizes, poor exposure characterization, and a few single nucleotide polymorphisms (SNPs) tested in candidate genes. We analyzed 25 SNPs (some previously untested) in 2101 primary lung cancer cases and 2120 population controls from the Environment And Genetics in Lung cancer Etiology (EAGLE) study from six phase I metabolic genes, including cytochrome P450s, microsomal epoxide hydrolase, and myeloperoxidase. We evaluated the main genotype effects and genotype-smoking interactions in lung cancer risk overall and in the major histology subtypes. We tested the combined effect of multiple SNPs on lung cancer risk and on gene expression. Findings were prioritized based on significance thresholds and consistency across different analyses, and accounted for multiple testing and prior knowledge. Two haplotypes in EPHX1 were significantly associated with lung cancer risk in the overall population. In addition, CYP1B1 and CYP2A6 polymorphisms were inversely associated with adenocarcinoma and squamous cell carcinoma risk, respectively. Moreover, the association between CYP1A1 rs2606345 genotype and lung cancer was significantly modified by intensity of cigarette smoking, suggesting an underlying dose-response mechanism. Finally, increasing number of variants at CYP1A1/A2 genes revealed significant protection in never smokers and risk in ever smokers. Results were supported by differential gene expression in non-tumor lung tissue samples with down-regulation of CYP1A1 in never smokers and up-regulation in smokers from CYP1A1/A2 SNPs. The significant haplotype associations emphasize that the effect of multiple SNPs may be important despite null single SNP-associations, and warrants consideration in genome-wide association studies (GWAS). Our findings emphasize the necessity of post-GWAS fine mapping and SNP functional assessment to further elucidate cancer risk associations. JF - PloS one AU - Rotunno, Melissa AU - Yu, Kai AU - Lubin, Jay H AU - Consonni, Dario AU - Pesatori, Angela C AU - Goldstein, Alisa M AU - Goldin, Lynn R AU - Wacholder, Sholom AU - Welch, Robert AU - Burdette, Laurie AU - Chanock, Stephen J AU - Bertazzi, Pier Alberto AU - Tucker, Margaret A AU - Caporaso, Neil E AU - Chatterjee, Nilanjan AU - Bergen, Andrew W AU - Landi, Maria Teresa AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America. Y1 - 2009/05/21/ PY - 2009 DA - 2009 May 21 SP - 1 VL - 4 IS - 5 KW - RNA, Messenger KW - 0 KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Index Medicus KW - Cytochrome P-450 CYP1A1 -- genetics KW - Odds Ratio KW - Humans KW - Aged KW - Linkage Disequilibrium -- genetics KW - Smoking -- genetics KW - RNA, Messenger -- genetics KW - False Positive Reactions KW - Haplotypes KW - RNA, Messenger -- metabolism KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Gene Expression Regulation, Neoplastic KW - Lung Neoplasms -- enzymology KW - Metabolic Detoxication, Phase I -- genetics KW - Lung Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - Polymorphism, Single Nucleotide -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67303098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Phase+I+metabolic+genes+and+risk+of+lung+cancer%3A+multiple+polymorphisms+and+mRNA+expression.&rft.au=Rotunno%2C+Melissa%3BYu%2C+Kai%3BLubin%2C+Jay+H%3BConsonni%2C+Dario%3BPesatori%2C+Angela+C%3BGoldstein%2C+Alisa+M%3BGoldin%2C+Lynn+R%3BWacholder%2C+Sholom%3BWelch%2C+Robert%3BBurdette%2C+Laurie%3BChanock%2C+Stephen+J%3BBertazzi%2C+Pier+Alberto%3BTucker%2C+Margaret+A%3BCaporaso%2C+Neil+E%3BChatterjee%2C+Nilanjan%3BBergen%2C+Andrew+W%3BLandi%2C+Maria+Teresa&rft.aulast=Rotunno&rft.aufirst=Melissa&rft.date=2009-05-21&rft.volume=4&rft.issue=5&rft.spage=e5652&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0005652 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-20 N1 - Date created - 2009-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Lett. 2005 Apr 28;221(2):185-90 [15808404] Biochim Biophys Acta. 1983 Dec 29;695(3-4):251-70 [6418203] Cancer Res. 2005 Jun 15;65(12):5105-11 [15958554] Biochem Biophys Res Commun. 2005 Dec 9;338(1):306-10 [16176798] Epidemiology. 2006 Jan;17(1):89-99 [16357600] Cancer Lett. 2006 Jun 8;237(1):102-8 [16005144] Mol Pharmacol. 2006 Jun;69(6):1924-30 [16505155] Clin Pharmacol Ther. 2006 Sep;80(3):282-97 [16952495] Lung Cancer. 2007 Mar;55(3):255-62 [17174438] Int J Epidemiol. 2007 Feb;36(1):236-41 [17510079] Lung Cancer. 2007 Jul;57(1):1-25 [17337085] Future Oncol. 2007 Dec;3(6):617-27 [18041914] Carcinogenesis. 1998 Feb;19(2):291-8 [9498279] Carcinogenesis. 1998 Mar;19(3):387-93 [9525271] Nature. 1998 Jun 25;393(6687):750 [9655391] Carcinogenesis. 1998 Oct;19(10):1847-53 [9806168] Lancet. 1999 Mar 13;353(9156):898-9 [10093988] Toxicology. 1999 Mar 1;133(1):1-33 [10413191] Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):405-13 [18268125] Mutat Res. 2008 Mar 1;639(1-2):1-10 [18082227] PLoS One. 2008;3(2):e1651 [18297132] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Nature. 2008 Apr 3;452(7187):633-7 [18385738] Nature. 2008 Apr 3;452(7187):638-42 [18385739] Carcinogenesis. 2008 Jun;29(6):1164-9 [18258609] BMC Public Health. 2008;8:203 [18538025] Mutat Res. 2008 Aug 25;643(1-2):4-10 [18573508] J Natl Cancer Inst. 2008 Nov 5;100(21):1552-6 [18957677] Nat Genet. 2008 Dec;40(12):1407-9 [18978787] Nat Genet. 2008 Dec;40(12):1404-6 [18978790] Lung Cancer. 2009 Feb;63(2):187-93 [18571762] Ann Oncol. 1999;10 Suppl 5:S7-11 [10582132] Pharmacogenetics. 2000 Feb;10(1):25-33 [10739169] Curr Opin Oncol. 2000 Mar;12(2):143-8 [10750726] Pharmacogenetics. 2000 Mar;10(2):105-14 [10761998] Cancer Res. 2000 Jul 1;60(13):3440-4 [10910054] Respir Med. 2000 Jun;94(6):564-8 [10921760] Chem Biol Interact. 2000 Dec 1;129(1-2):41-59 [11154734] Chem Res Toxicol. 2001 Jul;14(7):767-90 [11453723] Cancer Lett. 2001 Nov 28;173(2):155-62 [11597790] Histochem J. 2001 Jun;33(6):329-36 [11758809] Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):890-4 [12223434] Proc Natl Acad Sci U S A. 1985 Aug;82(15):5194-8 [2991910] Carcinogenesis. 1991 Mar;12(3):521-4 [1849053] Environ Health Perspect. 1992 Nov;98:69-74 [1486865] Pharmacogenetics. 1991 Oct;1(1):20-5 [1726950] Hum Mol Genet. 1994 Mar;3(3):421-8 [7516776] Cancer Res. 1996 Nov 1;56(21):4965-9 [8895751] Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1550-4 [12496042] Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1555-9 [12496043] Carcinogenesis. 2002 Dec;23(12):1969-77 [12507920] Cancer Causes Control. 2003 May;14(4):339-46 [12846365] Biochim Biophys Acta. 2003 Jul 30;1638(3):208-16 [12878321] Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):6002-11 [14676126] Cancer Sci. 2004 Jan;95(1):1-6 [14720319] J Natl Cancer Inst. 2004 Mar 17;96(6):434-42 [15026468] Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):828-33 [15159316] J Biol Chem. 2004 Jun 4;279(23):23847-50 [15028720] Xenobiotica. 1973 May;3(5):305-40 [4584115] Cancer Lett. 2005 Jun 8;223(2):265-74 [15896461] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0005652 ER - TY - JOUR T1 - Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. AN - 67258171; 19364970 AB - UGT1A1*28 is considered the main pharmacogenetic predictor of the toxicity outcome of irinotecan-treated patients. We evaluated the effect of other UGT1A variants and haplotypes involved in 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation on severe toxicity and efficacy of fluorouracil, leucovorin, and irinotecan (FOLFIRI). In addition to UGT1A1*28, UGT1A1*60, UGT1A1*93, UGT1A7*3, and UGT1A9*22 were genotyped in 250 metastatic colorectal cancer patients, and associations with severe hematologic and nonhematologic toxicity, objective response, time to progression (TTP), and overall survival were evaluated. In a subset of 71 patients, pharmacokinetic data were also available. UGT1A7*3 was the only marker of severe hematologic toxicity after the first cycle (odds ratio [OR], 3.94; 95% CI, 1.05 to 14.82; P = .04) in a multivariate analysis. It was also associated with glucuronidation ratio (SN-38G area under the curve [AUC]/SN-38 AUC) and biliary index (irinotecan AUC) x (SN-38 AUC/SN-38G AUC). Haplotype I (all the reference sequence alleles but UGT1A9*22) was a predictor of severe hematologic toxicity during the entire course of therapy (OR, 0.39; 95% CI, 0.19 to 0.82; P = .01), together with sex (OR, 2.08; 95% CI, 1.01 to 4.28; P = .05). In addition to UGT1A1*28, haplotype II (all the variant alleles but UGT1A9*22) was associated with a response rate (OR, 8.61; 95% CI, 1.75 to 42.38; P = .01). UGT1A1*28 was the only marker associated with TTP. We propose that UGT1A variants additional to UGT1A1*28 might improve the prediction of the outcome of colorectal cancer patients treated with FOLFIRI. A UGT1A haplotype-based approach might be an efficacious strategy to achieve treatment individualization of FOLFIRI. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Cecchin, Erika AU - Innocenti, Federico AU - D'Andrea, Mario AU - Corona, Giuseppe AU - De Mattia, Elena AU - Biason, Paola AU - Buonadonna, Angela AU - Toffoli, Giuseppe AD - Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy. Y1 - 2009/05/20/ PY - 2009 DA - 2009 May 20 SP - 2457 EP - 2465 VL - 27 IS - 15 KW - Biomarkers, Tumor KW - 0 KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - UDP-glucuronosyltransferase 1A9 KW - UGT1A7 protein, human KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Biomarkers, Tumor -- genetics KW - Polymorphism, Single Nucleotide KW - Area Under Curve KW - Humans KW - Camptothecin -- therapeutic use KW - Linkage Disequilibrium KW - Fluorouracil -- therapeutic use KW - Polymerase Chain Reaction KW - Haplotypes KW - Drug Resistance, Neoplasm -- genetics KW - Treatment Outcome KW - Camptothecin -- analogs & derivatives KW - Leucovorin -- therapeutic use KW - Glucuronosyltransferase -- genetics KW - Colorectal Neoplasms -- genetics KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Colorectal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67258171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Predictive+role+of+the+UGT1A1%2C+UGT1A7%2C+and+UGT1A9+genetic+variants+and+their+haplotypes+on+the+outcome+of+metastatic+colorectal+cancer+patients+treated+with+fluorouracil%2C+leucovorin%2C+and+irinotecan.&rft.au=Cecchin%2C+Erika%3BInnocenti%2C+Federico%3BD%27Andrea%2C+Mario%3BCorona%2C+Giuseppe%3BDe+Mattia%2C+Elena%3BBiason%2C+Paola%3BBuonadonna%2C+Angela%3BToffoli%2C+Giuseppe&rft.aulast=Cecchin&rft.aufirst=Erika&rft.date=2009-05-20&rft.volume=27&rft.issue=15&rft.spage=2457&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2008.19.0314 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-05 N1 - Date created - 2009-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Oncol. 2009 May 20;27(15):2419-21 [19364959] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2008.19.0314 ER - TY - CPAPER T1 - Ultrafine Mixed Oxide Cathode Material for Advanced Li-Ion Cells T2 - 2009 Central Regional Meeting of the American Chemical Society (CERMACS 2009) AN - 42132101; 5152645 JF - 2009 Central Regional Meeting of the American Chemical Society (CERMACS 2009) AU - Dai, Jinxiang AU - Skandan, Ganesh AU - Badway, Farid AU - Martin, Krista AU - Meng, Ying Y1 - 2009/05/20/ PY - 2009 DA - 2009 May 20 KW - Cathodes KW - Oxides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42132101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2009%29&rft.atitle=Ultrafine+Mixed+Oxide+Cathode+Material+for+Advanced+Li-Ion+Cells&rft.au=Dai%2C+Jinxiang%3BSkandan%2C+Ganesh%3BBadway%2C+Farid%3BMartin%2C+Krista%3BMeng%2C+Ying&rft.aulast=Dai&rft.aufirst=Jinxiang&rft.date=2009-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://acs.confex.com/acs/cerm09/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Mortality From Lymphohematopoietic Malignancies Among Workers in Formaldehyde Industries: The National Cancer Institute Cohort AN - 20744723; 9422266 AB - Background Formaldehyde exposure is associated with leukemia in some epidemiological studies. In the National Cancer Institute's formaldehyde cohort, previously followed through December 31, 1979, and updated through December 31, 1994, formaldehyde exposure was associated with an increased risk for leukemia, particularly myeloid leukemia, that increased with peak and average intensity of exposure.Methods We extended follow-up through December 31, 2004 (median follow-up = 42 years), for 25 619 workers employed at one of 10 formaldehyde-using or formaldehyde-producing plants before 1966. We used Poisson regression to calculate relative risk (RR) estimates and 95% confidence intervals (CIs) to examine associations between quantitative formaldehyde exposure estimates (peak exposure, average intensity and cumulative exposure) and death from lymphohematopoietic malignancies. All statistical tests were two-sided and considered to be significant at P = .05.Results When follow-up ended in 2004, there were statistically significant increased risks for the highest vs lowest peak formaldehyde exposure category ( greater than or equal to 4 parts per million [ppm] vs >0 to .50), all leukemia (RR = 1.42; 95% CI = 0.92 to 2.18, P trend = .12), and myeloid leukemia (RR = 1.78; 95% CI = 0.87 to 3.64, P trend = .13). There was little evidence of association for any lymphohematopoietic malignancy with average intensity or cumulative exposure at the end of follow-up in 2004. However, disease associations varied over time. For peak exposure, the highest formaldehyde-related risks for myeloid leukemia occurred before 1980, but trend tests attained statistical significance in 1990 only. After the mid-1990s, the formaldehyde-related risk of myeloid leukemia declined.Conclusions Evaluation of risks over time suggests a possible link between formaldehyde exposure and lymphohematopoietic malignancies, particularly myeloid leukemia but also perhaps Hodgkin lymphoma and multiple myeloma. Observed patterns could be due to chance but are also consistent with a causal association within the relatively short induction-incubation periods characteristic of leukemogenesis. Further epidemiological study and exploration of potential molecular mechanisms are warranted. JF - Journal of the National Cancer Institute AU - Beane Freeman, Laura E AU - Blair, Aaron AU - Lubin, Jay H AU - Stewart, Patricia A AU - Hayes, Richard B AU - Hoover, Robert N AU - Hauptmann, Michael Y1 - 2009/05/20/ PY - 2009 DA - 2009 May 20 SP - 751 EP - 761 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 101 IS - 10 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - Risk assessment KW - Molecular modelling KW - Mortality KW - Hodgkin's disease KW - multiple myeloma KW - Myeloid leukemia KW - Leukemogenesis KW - Statistical analysis KW - Formaldehyde KW - Cancer KW - Leukemia KW - Workers KW - Malignancy KW - Multiple myeloma KW - Risk factors KW - lymphoma KW - Occupational exposure KW - F 06915:Cancer Immunology KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20744723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Mortality+From+Lymphohematopoietic+Malignancies+Among+Workers+in+Formaldehyde+Industries%3A+The+National+Cancer+Institute+Cohort&rft.au=Beane+Freeman%2C+Laura+E%3BBlair%2C+Aaron%3BLubin%2C+Jay+H%3BStewart%2C+Patricia+A%3BHayes%2C+Richard+B%3BHoover%2C+Robert+N%3BHauptmann%2C+Michael&rft.aulast=Beane+Freeman&rft.aufirst=Laura&rft.date=2009-05-20&rft.volume=101&rft.issue=10&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp096 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Molecular modelling; Hodgkin's disease; Myeloid leukemia; Statistical analysis; Leukemogenesis; Formaldehyde; Workers; Malignancy; Multiple myeloma; Risk factors; Occupational exposure; Leukemia; multiple myeloma; lymphoma; Cancer DO - http://dx.doi.org/10.1093/jnci/djp096 ER - TY - CPAPER T1 - Human premature aging disorders are defective in DNA Repair T2 - 13th Congress of the International Association of Biomedical Gerontology (IABG 2009) AN - 42140943; 5148666 JF - 13th Congress of the International Association of Biomedical Gerontology (IABG 2009) AU - Bohr, Vilhelm Y1 - 2009/05/18/ PY - 2009 DA - 2009 May 18 KW - Aging KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42140943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Congress+of+the+International+Association+of+Biomedical+Gerontology+%28IABG+2009%29&rft.atitle=Human+premature+aging+disorders+are+defective+in+DNA+Repair&rft.au=Bohr%2C+Vilhelm&rft.aulast=Bohr&rft.aufirst=Vilhelm&rft.date=2009-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Congress+of+the+International+Association+of+Biomedical+Gerontology+%28IABG+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.hospitalite.com/Clients/geron09/images/prog_geronto.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Toxic IbsC Protein Expression in Escherichia coli T2 - 109th General Meeting of the American Society for Microbiology AN - 42144665; 5151304 JF - 109th General Meeting of the American Society for Microbiology AU - Fozo, E AU - Mendieta, K AU - Storz, G Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Proteins KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42144665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Effects+of+Toxic+IbsC+Protein+Expression+in+Escherichia+coli&rft.au=Fozo%2C+E%3BMendieta%2C+K%3BStorz%2C+G&rft.aulast=Fozo&rft.aufirst=E&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Secretion of the Escherichia coli O157:H7 Exoprotein OtpA via the Two-Partner Secretion Pathway Occurs in Two Discrete Steps T2 - 109th General Meeting of the American Society for Microbiology AN - 42144608; 5151536 JF - 109th General Meeting of the American Society for Microbiology AU - Choi, P AU - Bernstein, H Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Secretion KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42144608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Secretion+of+the+Escherichia+coli+O157%3AH7+Exoprotein+OtpA+via+the+Two-Partner+Secretion+Pathway+Occurs+in+Two+Discrete+Steps&rft.au=Choi%2C+P%3BBernstein%2C+H&rft.aulast=Choi&rft.aufirst=P&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigating the Mechanism of fim Gene Activation in Bordetella pertussis T2 - 109th General Meeting of the American Society for Microbiology AN - 42135032; 5150692 JF - 109th General Meeting of the American Society for Microbiology AU - Baxter, K AU - Hinton, D AU - Chen, Q AU - Boucher, P AU - Stibitz, S Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Pertussis KW - FIM gene KW - Bordetella pertussis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42135032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Investigating+the+Mechanism+of+fim+Gene+Activation+in+Bordetella+pertussis&rft.au=Baxter%2C+K%3BHinton%2C+D%3BChen%2C+Q%3BBoucher%2C+P%3BStibitz%2C+S&rft.aulast=Baxter&rft.aufirst=K&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Examination of the Chlamydial Inclusion's Preferential Interception of Basolaterally Trafficked Exocytic Vesicles T2 - 109th General Meeting of the American Society for Microbiology AN - 42134618; 5150576 JF - 109th General Meeting of the American Society for Microbiology AU - Moore, E AU - Mead, D AU - Hackstadt, T Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Vesicles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42134618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Examination+of+the+Chlamydial+Inclusion%27s+Preferential+Interception+of+Basolaterally+Trafficked+Exocytic+Vesicles&rft.au=Moore%2C+E%3BMead%2C+D%3BHackstadt%2C+T&rft.aulast=Moore&rft.aufirst=E&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multi-Species Biofilm Formation by Streptococcus gordonii, Actinomyces naeslundii and Caries Pathogen Streptococcus mutans T2 - 109th General Meeting of the American Society for Microbiology AN - 42134049; 5150741 JF - 109th General Meeting of the American Society for Microbiology AU - Chalmers, N AU - Tanner, A AU - Kolenbrander, P AU - Du-Thumm, L AU - Sullivan, R Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Pathogens KW - Biofilms KW - Dental caries KW - Streptococcus gordonii KW - Streptococcus mutans KW - Actinomyces naeslundii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42134049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Multi-Species+Biofilm+Formation+by+Streptococcus+gordonii%2C+Actinomyces+naeslundii+and+Caries+Pathogen+Streptococcus+mutans&rft.au=Chalmers%2C+N%3BTanner%2C+A%3BKolenbrander%2C+P%3BDu-Thumm%2C+L%3BSullivan%2C+R&rft.aulast=Chalmers&rft.aufirst=N&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Basis of Coaggeragation Receptor Polysaccharide Biosynthesis in Streptococcus sanguinis SK45 T2 - 109th General Meeting of the American Society for Microbiology AN - 42127360; 5150454 JF - 109th General Meeting of the American Society for Microbiology AU - Yang, J AU - Cisar, J AU - Yoshida, Y Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Biosynthesis KW - Polysaccharides KW - Streptococcus sanguinis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42127360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Molecular+Basis+of+Coaggeragation+Receptor+Polysaccharide+Biosynthesis+in+Streptococcus+sanguinis+SK45&rft.au=Yang%2C+J%3BCisar%2C+J%3BYoshida%2C+Y&rft.aulast=Yang&rft.aufirst=J&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Virulence Determinants Identified through Transcriptional Profiling of Intracellular Francisella tularensis T2 - 109th General Meeting of the American Society for Microbiology AN - 42125032; 5150442 JF - 109th General Meeting of the American Society for Microbiology AU - Wehrly, T AU - Chong, A AU - Virtaneva, K AU - Sturdevant, D AU - Child, R AU - Edwards, J AU - Brouwer, D AU - Nair, V AU - Fischer, E AU - Wicke, L AU - Curda, A AU - Kupko III, J AU - Martens, C AU - Crane, D AU - Bosio, C AU - Porcella, S AU - Celli, J Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Virulence KW - Transcription KW - Profiling KW - Francisella tularensis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42125032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Novel+Virulence+Determinants+Identified+through+Transcriptional+Profiling+of+Intracellular+Francisella+tularensis&rft.au=Wehrly%2C+T%3BChong%2C+A%3BVirtaneva%2C+K%3BSturdevant%2C+D%3BChild%2C+R%3BEdwards%2C+J%3BBrouwer%2C+D%3BNair%2C+V%3BFischer%2C+E%3BWicke%2C+L%3BCurda%2C+A%3BKupko+III%2C+J%3BMartens%2C+C%3BCrane%2C+D%3BBosio%2C+C%3BPorcella%2C+S%3BCelli%2C+J&rft.aulast=Wehrly&rft.aufirst=T&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Identification of Emerging Pathogens within Scedosporium spp. T2 - 109th General Meeting of the American Society for Microbiology AN - 42122427; 5150342 JF - 109th General Meeting of the American Society for Microbiology AU - Cortez, K AU - Holland, S AU - Shea, Y AU - Zelazny, A Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Pathogens KW - Scedosporium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42122427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Molecular+Identification+of+Emerging+Pathogens+within+Scedosporium+spp.&rft.au=Cortez%2C+K%3BHolland%2C+S%3BShea%2C+Y%3BZelazny%2C+A&rft.aulast=Cortez&rft.aufirst=K&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D-galactose Metabolite Accumulation Causes Pyrimidine Deficiency in E. coli T2 - 109th General Meeting of the American Society for Microbiology AN - 42118625; 5149915 JF - 109th General Meeting of the American Society for Microbiology AU - Lee, S AU - Trostel, A AU - Le, P. AU - Fitzgerald, P AU - Adhya, S AU - Harinarayanan, R Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Metabolites KW - Pyrimidines KW - D-Galactose KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42118625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=D-galactose+Metabolite+Accumulation+Causes+Pyrimidine+Deficiency+in+E.+coli&rft.au=Lee%2C+S%3BTrostel%2C+A%3BLe%2C+P.%3BFitzgerald%2C+P%3BAdhya%2C+S%3BHarinarayanan%2C+R&rft.aulast=Lee&rft.aufirst=S&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synaptic remodeling by A-type K+ channels in CA1 pyramidal neuron dendrites T2 - 2009 Gordon Research Conference on Dendrites: Molecules, Structure and Function AN - 41905123; 5116155 JF - 2009 Gordon Research Conference on Dendrites: Molecules, Structure and Function AU - Hoffman, Dax Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Potassium channels KW - Dendrites KW - Pyramidal cells KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41905123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Dendrites%3A+Molecules%2C+Structure+and+Function&rft.atitle=Synaptic+remodeling+by+A-type+K%2B+channels+in+CA1+pyramidal+neuron+dendrites&rft.au=Hoffman%2C+Dax&rft.aulast=Hoffman&rft.aufirst=Dax&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Dendrites%3A+Molecules%2C+Structure+and+Function&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=dendrites LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Brain activation abnormalities during speech and non-speech in stuttering speakers AN - 746076830; 12978503 AB - Although stuttering is regarded as a speech-specific disorder, there is a growing body of evidence suggesting that subtle abnormalities in the motor planning and execution of non-speech gestures exist in stuttering individuals. We hypothesized that people who stutter (PWS) would differ from fluent controls in their neural responses during motor planning and execution of both speech and non-speech gestures that had auditory targets. Using fMRI with sparse sampling, separate BOLD responses were measured for perception, planning, and fluent production of speech and non-speech vocal tract gestures. During both speech and non-speech perception and planning, PWS had less activation in the frontal and temporoparietal regions relative to controls. During speech and non-speech production, PWS had less activation than the controls in the left superior temporal gyrus (STG) and the left pre-motor areas (BA 6) but greater activation in the right STG, bilateral Heschl's gyrus (HG), insula, putamen, and precentral motor regions (BA 4). Differences in brain activation patterns between PWS and controls were greatest in females and less apparent in males. In conclusion, similar differences in PWS from the controls were found during speech and non-speech; during perception and planning they had reduced activation while during production they had increased activity in the auditory area on the right and decreased activation in the left sensorimotor regions. These results demonstrated that neural activation differences in PWS are not speech-specific. JF - NeuroImage AU - Chang, Soo-Eun AU - Kenney, Mary Kay AU - Loucks, Torrey MJ AU - Ludlow, Christy L AD - Laryngeal and Speech Section, Medical Neurology Branch, NINDS/NIH, 10 Center Dr. MSC 1416 Building 10, Room 5D38, Bethesda, MD 20892, USA, ludlowc@ninds.nih.gov Y1 - 2009/05/15/ PY - 2009 DA - 2009 May 15 SP - 201 EP - 212 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 46 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Stuttering KW - Speech perception KW - Planning KW - Production KW - Non-speech KW - Functional magnetic resonance imaging (fMRI) KW - Auditory-motor interaction KW - Forward model KW - Brain mapping KW - sensorimotor system KW - speech KW - Neuroimaging KW - Perception KW - superior temporal gyrus KW - Functional magnetic resonance imaging KW - speech perception KW - Sampling KW - Putamen KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746076830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Brain+activation+abnormalities+during+speech+and+non-speech+in+stuttering+speakers&rft.au=Chang%2C+Soo-Eun%3BKenney%2C+Mary+Kay%3BLoucks%2C+Torrey+MJ%3BLudlow%2C+Christy+L&rft.aulast=Chang&rft.aufirst=Soo-Eun&rft.date=2009-05-15&rft.volume=46&rft.issue=1&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.01.066 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - sensorimotor system; Brain mapping; Neuroimaging; speech; superior temporal gyrus; Perception; Functional magnetic resonance imaging; speech perception; Sampling; Putamen DO - http://dx.doi.org/10.1016/j.neuroimage.2009.01.066 ER - TY - JOUR T1 - A phase I trial of enzastaurin in patients with recurrent gliomas. AN - 67247192; 19417015 AB - Enzastaurin is a selective inhibitor of protein kinase C beta. Prior phase I studies did not show increased drug exposures with escalating once daily administration. Limits from gastrointestinal absorption may be overcome by twice daily dosing, potentially improving antitumor effects. We conducted a phase I dose escalation study in 26 patients with recurrent malignant glioma, stratified by use of enzyme-inducing antiepileptic drugs, to investigate whether divided twice daily dosing results in higher exposures compared with once daily dosing. Phosphorylated glycogen synthase 3 beta was analyzed as a potential biomarker of enzastaurin activity. Enzastaurin was poorly tolerated at all dose levels evaluated (500, 800, and 1,000 mg total daily), with thrombocytopenia and prolonged QTc as dose-limiting toxicities. The average drug concentration of enzastaurin under steady-state conditions was doubled by twice daily dosing compared with daily dosing [1.990; 90% confidence interval (CI), 1.450-2.730]. Additionally, geometric mean ratios doubled with 800 versus 500 mg dosing for both daily (2.687; 90% CI, 1.232-5.860) and twice daily regimens (1.852; 90% CI, 0.799-4.292). Two patients achieved long-term benefit (over 150 weeks progression free). Higher and more frequent dosing of enzastaurin resulted in improved drug exposure but with unacceptable toxicity at the doses tested. Phosphorylated glycogen synthase 3 beta may be a useful biomarker of the biological activity of enzastaurin. Enzastaurin has activity in a subset of malignant glioma patients and warrants continued study in combination with other agents using a maximal once daily dose of 500 mg. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kreisl, Teri N AU - Kim, Lyndon AU - Moore, Kraig AU - Duic, Paul AU - Kotliarova, Svetlana AU - Walling, Jennifer AU - Musib, Luna AU - Thornton, Donald AU - Albert, Paul S AU - Fine, Howard A AD - Neuro-Oncology Branch and Biometric Research Branch, National Cancer Institute, National Institute of Neurological Disorder and Stroke, NIH, Bethesda, MD 20892, USA. Y1 - 2009/05/15/ PY - 2009 DA - 2009 May 15 SP - 3617 EP - 3623 VL - 15 IS - 10 SN - 1078-0432, 1078-0432 KW - Indoles KW - 0 KW - Phosphoproteins KW - Glycogen Synthase Kinase 3 beta KW - EC 2.7.11.1 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Protein Kinase C beta KW - Glycogen Synthase Kinase 3 KW - EC 2.7.11.26 KW - enzastaurin KW - UC96G28EQF KW - Index Medicus KW - Long QT Syndrome -- chemically induced KW - Area Under Curve KW - Dose-Response Relationship, Drug KW - Glycogen Synthase Kinase 3 -- blood KW - Humans KW - Metabolic Clearance Rate KW - Protein Kinase C -- antagonists & inhibitors KW - Adult KW - Cross-Over Studies KW - Thrombocytopenia -- chemically induced KW - Neoplasm Recurrence, Local KW - Phosphoproteins -- blood KW - Survival Analysis KW - Glioma -- pathology KW - Indoles -- pharmacokinetics KW - Glioma -- drug therapy KW - Indoles -- adverse effects KW - Indoles -- therapeutic use KW - Glioma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67247192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+phase+I+trial+of+enzastaurin+in+patients+with+recurrent+gliomas.&rft.au=Kreisl%2C+Teri+N%3BKim%2C+Lyndon%3BMoore%2C+Kraig%3BDuic%2C+Paul%3BKotliarova%2C+Svetlana%3BWalling%2C+Jennifer%3BMusib%2C+Luna%3BThornton%2C+Donald%3BAlbert%2C+Paul+S%3BFine%2C+Howard+A&rft.aulast=Kreisl&rft.aufirst=Teri&rft.date=2009-05-15&rft.volume=15&rft.issue=10&rft.spage=3617&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-08-3071 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-03 N1 - Date created - 2009-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-08-3071 ER - TY - JOUR T1 - Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound. AN - 67185384; 19364650 AB - Here we report a number of novel JS-K structural analogues with sub-micromolar anti-proliferative activities against human leukemia cell lines HL-60 and U937; JS-K is the anti-cancer lead compound O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate. The ability of these compounds to generate intracellular nitric oxide correlated well with their observed anti-proliferative effects: analogues that had potent inhibitory activity against leukemia cells formed elevated levels of intracellular nitric oxide. JF - Bioorganic & medicinal chemistry letters AU - Nandurdikar, Rahul S AU - Maciag, Anna E AU - Citro, Michael L AU - Shami, Paul J AU - Keefer, Larry K AU - Saavedra, Joseph E AU - Chakrapani, Harinath AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, MD 21702, USA. Y1 - 2009/05/15/ PY - 2009 DA - 2009 May 15 SP - 2760 EP - 2762 VL - 19 IS - 10 KW - Antineoplastic Agents KW - 0 KW - Azo Compounds KW - O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate KW - Piperazines KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Humans KW - Nitric Oxide -- metabolism KW - Cell Line, Tumor KW - Azo Compounds -- chemical synthesis KW - Piperazines -- chemical synthesis KW - Piperazines -- chemistry KW - Azo Compounds -- chemistry KW - Azo Compounds -- pharmacology KW - Antineoplastic Agents -- chemical synthesis KW - Piperazines -- pharmacology KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67185384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.atitle=Synthesis+and+evaluation+of+piperazine+and+homopiperazine+analogues+of+JS-K%2C+an+anti-cancer+lead+compound.&rft.au=Nandurdikar%2C+Rahul+S%3BMaciag%2C+Anna+E%3BCitro%2C+Michael+L%3BShami%2C+Paul+J%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E%3BChakrapani%2C+Harinath&rft.aulast=Nandurdikar&rft.aufirst=Rahul&rft.date=2009-05-15&rft.volume=19&rft.issue=10&rft.spage=2760&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry+letters&rft.issn=1464-3405&rft_id=info:doi/10.1016%2Fj.bmcl.2009.03.115 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-29 N1 - Date created - 2009-05-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cancer Ther. 2003 Apr;2(4):409-17 [12700285] J Cell Physiol. 2003 Dec;197(3):426-34 [14566972] Mol Cancer Ther. 2004 Jun;3(6):709-14 [15210857] J Med Chem. 2006 Jul 13;49(14):4356-66 [16821795] Leuk Res. 2006 Oct;30(10):1279-83 [16439016] Oncogene. 2009 Jan 29;28(4):619-24 [18978812] Bioorg Med Chem Lett. 2008 Feb 1;18(3):950-3 [18178089] Breast Cancer Res. 2008;10(3):R44 [18474097] Bioorg Med Chem. 2008 Nov 15;16(22):9764-71 [18930407] Org Lett. 2008 Nov 20;10(22):5155-8 [18956868] J Med Chem. 2008 Dec 25;51(24):7944-52 [19053760] Blood. 2007 Jul 15;110(2):709-18 [17384201] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bmcl.2009.03.115 ER - TY - JOUR T1 - Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network. AN - 67165523; 19251246 AB - Hypocretin (Hcrt), an arousal- and feeding-associated peptide, is expressed in lateral hypothalamic neurons that project to the ventral tegmental area (VTA). Intra-VTA Hcrt reinstates morphine-conditioned place preferences, and intracerebroventricular and intra-VTA corticotropin-releasing factor (CRF) reinstate cocaine seeking. Each is presumed to act, at least in part, through actions local to the VTA. Here, we examined the possibility that VTA perfusion of Hcrt reinstates cocaine seeking and, if so, whether it does so through the VTA mechanism that is implicated in reinstatement by CRF. Rats were trained to lever-press for intravenous cocaine (2 weeks) and then underwent extinction training (saline substituted for cocaine: 3 weeks). Reinstatement behavior was tested and VTA dialysates were collected and assayed for glutamate or dopamine following footshock or perfusion of Hcrt or CRF, with or without Hcrt or CRF antagonists, into the VTA. Ventral tegmental area perfusion of Hcrt-1 or footshock stress reinstated cocaine seeking and caused release of VTA glutamate and dopamine. The effects of Hcrt-1 were blocked by a selective Hcrt-1 antagonist, but not a CRF antagonist, and were not mimicked by Hcrt-2. The Hcrt-1 antagonist did not block CRF-dependent footshock-induced reinstatement or glutamate or dopamine release. The behavioral and neurochemical effects of Hcrt-1 were attenuated but not blocked by kynurenic acid, an ionotropic glutamate antagonist that blocks footshock-induced reinstatement and glutamate release. While Hcrt and CRF are known to interact in some area of the brain, in the VTA proper they appear to have largely independent actions on the mesolimbic dopamine mechanisms of cocaine seeking. JF - Biological psychiatry AU - Wang, Bin AU - You, Zhi-Bing AU - Wise, Roy A AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2009/05/15/ PY - 2009 DA - 2009 May 15 SP - 857 EP - 862 VL - 65 IS - 10 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - Neuropeptides KW - Orexin Receptors KW - Orexins KW - Phenylurea Compounds KW - Receptors, Corticotropin-Releasing Hormone KW - Receptors, G-Protein-Coupled KW - Receptors, Kainic Acid KW - Receptors, Neuropeptide KW - SB 408124 KW - Glutamic Acid KW - 3KX376GY7L KW - Kynurenic Acid KW - H030S2S85J KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Drug Interactions KW - Rats, Long-Evans KW - Glutamic Acid -- metabolism KW - Receptors, Neuropeptide -- antagonists & inhibitors KW - Dopamine -- metabolism KW - Kynurenic Acid -- pharmacology KW - Rats KW - Receptors, G-Protein-Coupled -- antagonists & inhibitors KW - Self Administration KW - Kynurenic Acid -- administration & dosage KW - Phenylurea Compounds -- antagonists & inhibitors KW - Receptors, Kainic Acid -- antagonists & inhibitors KW - Electroshock KW - Male KW - Neuropeptides -- pharmacology KW - Neuropeptides -- administration & dosage KW - Ventral Tegmental Area -- metabolism KW - Receptors, Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Intracellular Signaling Peptides and Proteins -- pharmacology KW - Ventral Tegmental Area -- drug effects KW - Cocaine -- pharmacology KW - Cocaine -- administration & dosage KW - Intracellular Signaling Peptides and Proteins -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67165523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Reinstatement+of+cocaine+seeking+by+hypocretin+%28orexin%29+in+the+ventral+tegmental+area%3A+independence+from+the+local+corticotropin-releasing+factor+network.&rft.au=Wang%2C+Bin%3BYou%2C+Zhi-Bing%3BWise%2C+Roy+A&rft.aulast=Wang&rft.aufirst=Bin&rft.date=2009-05-15&rft.volume=65&rft.issue=10&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=1873-2402&rft_id=info:doi/10.1016%2Fj.biopsych.2009.01.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-30 N1 - Date created - 2009-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuropsychopharmacology. 2006 Feb;31(2):384-95 [15988471] J Neurosci. 2006 Jan 11;26(2):398-405 [16407535] J Pharmacol Exp Ther. 2006 Apr;317(1):163-71 [16352704] Anesthesiology. 2006 May;104(5):1023-32 [16645455] Neuroscience. 2006 Sep 1;141(3):1101-5 [16820265] Eur J Neurosci. 2007 Mar;25(5):1537-45 [17425580] J Comp Neurol. 2007 Aug 10;503(5):668-84 [17559101] Psychopharmacology (Berl). 2007 Aug;193(2):283-94 [17437087] J Neurosci. 2007 Sep 26;27(39):10546-55 [17898226] Physiol Behav. 2008 Mar 18;93(4-5):947-51 [18262574] J Neurosci. 2008 Sep 3;28(36):9021-9 [18768696] J Neurosci. 2000 Feb 15;20(4):1635-42 [10662853] Peptides. 1999 Dec;20(12):1455-70 [10698122] Br J Pharmacol. 2000 Apr;129(7):1289-91 [10742282] J Comp Neurol. 2001 Jun 18;435(1):6-25 [11370008] Neurosci Lett. 2002 Apr 26;323(2):93-6 [11950501] Nat Rev Neurosci. 2002 May;3(5):339-49 [11988773] Annu Rev Neurosci. 2002;25:283-313 [12052911] J Neurosci. 2003 Jan 1;23(1):7-11 [12514194] Annu Rev Psychol. 1989;40:191-225 [2648975] Psychopharmacology (Berl). 1996 Jun;125(4):385-91 [8826544] Annu Rev Neurosci. 1996;19:319-40 [8833446] Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7 [9419374] Cell. 1998 Feb 20;92(4):573-85 [9491897] J Neurosci. 1998 Dec 1;18(23):9996-10015 [9822755] Synapse. 1999 Mar 15;31(4):241-9 [10051104] Br J Pharmacol. 1999 Sep;128(1):1-3 [10498827] J Neurosci. 2005 Jun 1;25(22):5389-96 [15930388] Nature. 2005 Sep 22;437(7058):556-9 [16100511] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19168-73 [16357203] Neuron. 2006 Feb 16;49(4):589-601 [16476667] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.biopsych.2009.01.018 ER - TY - JOUR T1 - Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort. AN - 67084281; 19142867 AB - Pancreatic cancer is a rapidly fatal disease that has been linked with pesticide use. Previous studies have reported excess risks of pancreatic cancer with organochlorines such as DDT, however, many other commonly used pesticides have not been examined. To further examine the potential associations between the use of a number of pesticides and pancreatic cancer, we conducted a case-control analysis in the Agricultural Health Study, one of the largest prospective cohorts with over 89,000 participants including pesticide applicators and their spouses in Iowa and North Carolina. This analysis included 93 incident pancreatic cancer cases (64 applicators, 29 spouses) and 82,503 cancer-free controls who completed an enrollment questionnaire providing detailed pesticide use, demographic and lifestyle information. Ever use of 24 pesticides and intensity-weighted lifetime days [(lifetime exposure days) x (exposure intensity score)] of 13 pesticides was assessed. Risk estimates were calculated using unconditional logistic regression controlling for age, smoking, and diabetes. Among pesticide applicators, 2 herbicides (EPTC and pendimethalin) of the 13 pesticides examined for intensity-weighted lifetime use showed a statistically significant exposure-response association with pancreatic cancer. Applicators in the top half of lifetime pendimethalin use had a 3.0-fold (95% CI 1.3-7.2, p-trend = 0.01) risk compared with never users, and those in the top half of lifetime EPTC use had a 2.56-fold (95% CI = 1.1-5.4, p-trend = 0.01) risk compared with never users. Organochlorines were not associated with an excess risk of pancreatic cancer in this study. These findings suggest that herbicides, particularly pendimethalin and EPTC, may be associated with pancreatic cancer. (c) 2008 Wiley-Liss, Inc. JF - International journal of cancer AU - Andreotti, Gabriella AU - Freeman, Laura E Beane AU - Hou, Lifang AU - Coble, Joseph AU - Rusiecki, Jennifer AU - Hoppin, Jane A AU - Silverman, Debra T AU - Alavanja, Michael C R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. andreotg@mail.nih.gov Y1 - 2009/05/15/ PY - 2009 DA - 2009 May 15 SP - 2495 EP - 2500 VL - 124 IS - 10 KW - Carcinogens KW - 0 KW - Pesticides KW - Index Medicus KW - Registries KW - Prospective Studies KW - Humans KW - Surveys and Questionnaires KW - Case-Control Studies KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Occupational Exposure KW - Agriculture KW - Pancreatic Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Pancreatic Neoplasms -- epidemiology KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67084281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Agricultural+pesticide+use+and+pancreatic+cancer+risk+in+the+Agricultural+Health+Study+Cohort.&rft.au=Andreotti%2C+Gabriella%3BFreeman%2C+Laura+E+Beane%3BHou%2C+Lifang%3BCoble%2C+Joseph%3BRusiecki%2C+Jennifer%3BHoppin%2C+Jane+A%3BSilverman%2C+Debra+T%3BAlavanja%2C+Michael+C+R&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2009-05-15&rft.volume=124&rft.issue=10&rft.spage=2495&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.24185 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-14 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1997 Jul 3;72(1):62-7 [9212224] Environ Health Perspect. 2008 Nov;116(11):1541-6 [19057708] Am J Ind Med. 1999 Aug;36(2):239-47 [10398932] Epidemiology. 2006 May;17(3):302-7 [16452832] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Lancet. 1999 Dec 18-25;354(9196):2125-9 [10609819] Cancer Epidemiol Biomarkers Prev. 2000 Feb;9(2):199-205 [10698482] Am J Ind Med. 2001 Jan;39(1):92-9 [11148019] J Occup Environ Med. 2001 Jul;43(7):641-9 [11464396] Epidemiology. 2002 Jan;13(1):94-9 [11805592] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] Am J Epidemiol. 2003 May 1;157(9):800-14 [12727674] Occup Environ Med. 2004 Sep;61(9):743-9 [15317914] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] Cancer Res. 1988 Dec 1;48(23):6912-7 [3180100] Cancer Surv. 1989;8(2):459-73 [2696590] IARC Sci Publ. 1991;(105):54-61 [1855913] J Natl Cancer Inst. 1992 May 20;84(10):764-71 [1573662] J Natl Cancer Inst. 1994 Oct 19;86(20):1510-6 [7932805] Epidemiology. 1995 Sep;6(5):498-502 [8562625] Am J Ind Med. 1997 Feb;31(2):233-42 [9028440] Environ Health Perspect. 1998 Aug;106(8):437-45 [9681970] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.24185 ER - TY - JOUR T1 - Preface: Natural Products in Medicinal Chemistry AN - 20469031; 9135834 JF - Bioorganic and Medicinal Chemistry AU - Newman, David AU - Cragg, Gordon AD - Natural Products Branch, NCI Y1 - 2009/05/15/ PY - 2009 DA - 2009 May 15 SP - 2120 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 6 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - natural products KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20469031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Preface%3A+Natural+Products+in+Medicinal+Chemistry&rft.au=Newman%2C+David%3BCragg%2C+Gordon&rft.aulast=Newman&rft.aufirst=David&rft.date=2009-05-15&rft.volume=17&rft.issue=6&rft.spage=2120&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2009.03.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - natural products DO - http://dx.doi.org/10.1016/j.bmc.2009.03.010 ER - TY - JOUR T1 - Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: Implications for alcohol-related carcinogenesis AN - 20562852; 9264999 AB - According to a recent IARC Working Group report, alcohol consumption is causally related to an increased risk of cancer of the upper aerodigestive tract, liver, colorectum, and female breast [R. Baan, K. Straif, Y. Grosse, B. Secretan, F. El Ghissassi, V. Bouvard, A. Altieri, V. Cogliano, Carcinogenicity of alcoholic beverages, Lancet Oncol. 8 (2007) 292-293]. Several lines of evidence indicate that acetaldehyde (AA), the first product of alcohol metabolism, plays a very important role in alcohol-related carcinogenesis, particularly in the esophagus. We previously proposed a model for alcohol-related carcinogenesis in which AA, generated from alcohol metabolism, reacts in cells to generate DNA lesions that form interstrand crosslinks (ICLs) [J.A. Theruvathu, P. Jaruga, R.G. Nath, M. Dizdaroglu, P.J. Brooks, Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde, Nucleic Acids Res. 33 (2005) 3513-3520]. Since the Fanconi anemia-breast cancer associated (FANC-BRCA) DNA damage response network plays a crucial role in protecting cells against ICLs, in the present work we tested this hypothesis by exposing cells to AA and monitoring activation of this network. We found that AA exposure results in a concentration-dependent increase in FANCD2 monoubiquitination, which is dependent upon the FANC core complex. AA also stimulated BRCA1 phosphorylation at Ser1524 and increased the level of gH2AX, with both modifications occurring in a dose-dependent manner. However, AA did not detectably increase the levels of hyperphosphorylated RPA34, a marker of single-stranded DNA exposure at replication forks. These results provide the initial description of the AA-DNA damage response, which is qualitatively similar to the cellular response to mitomycin C, a known DNA crosslinking agent. We discuss the mechanistic implications of these results, as well as their possible relationship to alcohol-related carcinogenesis in different human tissues. JF - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis AU - Marietta, C AU - Thompson, L H AU - Lamerdin, JE AU - Brooks, P J AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane, Room 3S32, Rockville, MD 20852, United States, pjbrooks@mail.nih.gov Y1 - 2009/05/12/ PY - 2009 DA - 2009 May 12 SP - 77 EP - 83 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 664 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Toxicology Abstracts KW - Esophagus KW - DNA biosynthesis KW - Molecular modelling KW - Alcoholic beverages KW - Acetaldehyde KW - Adducts KW - Mitomycin C KW - Cancer KW - Mutagenesis KW - DNA damage KW - ubiquitination KW - nucleic acids KW - Phosphorylation KW - Replication forks KW - polyamines KW - Carcinogenesis KW - Liver KW - BRCA1 protein KW - Metabolism KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20562852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.atitle=Acetaldehyde+stimulates+FANCD2+monoubiquitination%2C+H2AX+phosphorylation%2C+and+BRCA1+phosphorylation+in+human+cells+in+vitro%3A+Implications+for+alcohol-related+carcinogenesis&rft.au=Marietta%2C+C%3BThompson%2C+L+H%3BLamerdin%2C+JE%3BBrooks%2C+P+J&rft.aulast=Marietta&rft.aufirst=C&rft.date=2009-05-12&rft.volume=664&rft.issue=1-2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrfmmm.2009.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Esophagus; Molecular modelling; DNA biosynthesis; Alcoholic beverages; Adducts; Acetaldehyde; Mitomycin C; Cancer; Mutagenesis; ubiquitination; DNA damage; nucleic acids; Replication forks; Phosphorylation; polyamines; Carcinogenesis; Liver; BRCA1 protein; Metabolism; Ethanol DO - http://dx.doi.org/10.1016/j.mrfmmm.2009.03.011 ER - TY - CPAPER T1 - A Latent Model Approach to Estimation of the False Positive Rate for Multiple Screening Exams with Incomplete Test Results T2 - 5th Conference of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2009) AN - 41796768; 5027072 JF - 5th Conference of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2009) AU - Hu, P. Y1 - 2009/05/10/ PY - 2009 DA - 2009 May 10 KW - Models KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41796768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Conference+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2009%29&rft.atitle=A+Latent+Model+Approach+to+Estimation+of+the+False+Positive+Rate+for+Multiple+Screening+Exams+with+Incomplete+Test+Results&rft.au=Hu%2C+P.&rft.aulast=Hu&rft.aufirst=P.&rft.date=2009-05-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Conference+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibs-emr2009.com/sci_prog.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detecting Gene-Gene Interactions Using Genome-Wide Association Studies in Presence of Population Stratification T2 - 5th Conference of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2009) AN - 41750224; 5027101 JF - 5th Conference of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2009) AU - Chatterjee, N Y1 - 2009/05/10/ PY - 2009 DA - 2009 May 10 KW - Stratification KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41750224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Conference+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2009%29&rft.atitle=Detecting+Gene-Gene+Interactions+Using+Genome-Wide+Association+Studies+in+Presence+of+Population+Stratification&rft.au=Chatterjee%2C+N&rft.aulast=Chatterjee&rft.aufirst=N&rft.date=2009-05-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Conference+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibs-emr2009.com/sci_prog.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2) gene. AN - 67202150; 19279013 AB - The transcription factors GATA-1 and GATA-2 have been implicated in promoting differentiation of eosinophilic leukocytes. In this study, we examined the roles of GATA-1 and GATA-2 in activating transcription of the secretory ribonuclease, the eosinophil-derived neurotoxin (EDN/RNase 2). Augmented expression of both GATA-1 and GATA-2 was detected in eosinophil promyelocyte HL-60 clone 15 cells in response to biochemical differentiation with butyric acid. Deletion or mutation of one or both of the two consensus GATA-binding sites in the extended 1000-bp 5' promoter of the EDN gene resulted in profound reduction in reporter gene activity. Antibody-augmented electrophoretic mobility shift and chromatin immunoprecipitation analyses indicate that GATA-1 and GATA-2 proteins bind to both functional GATA consensus sequences in the EDN promoter. Interestingly, RNA silencing of GATA-1 alone had no impact on EDN expression; silencing of GATA-2 resulted in diminished expression of EDN, and also diminished expression of GATA-1 in both butyric acid-induced HL-60 clone 15 cells and in differentiating human eosinophils derived from CD34(+) hematopoietic progenitors. Likewise, overexpression of GATA-2 in uninduced HL-60 clone 15 cells resulted in augmented transcription of both EDN and GATA-1. Taken together, our data suggest that GATA-2 functions directly via interactions with the EDN promoter and also indirectly, via its ability to regulate the expression of GATA-1 in differentiating eosinophils and eosinophil cell lines. JF - The Journal of biological chemistry AU - Qiu, Zhijun AU - Dyer, Kimberly D AU - Xie, Zhihui AU - Rådinger, Madeleine AU - Rosenberg, Helene F AD - Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD 20892, USA. Y1 - 2009/05/08/ PY - 2009 DA - 2009 May 08 SP - 13099 EP - 13109 VL - 284 IS - 19 SN - 0021-9258, 0021-9258 KW - GATA1 Transcription Factor KW - 0 KW - GATA1 protein, human KW - GATA2 Transcription Factor KW - GATA2 protein, human KW - RNA, Messenger KW - RNA, Small Interfering KW - Eosinophil-Derived Neurotoxin KW - EC 3.1.- KW - RNASE2 protein, human KW - EC 3.1.27.5 KW - Index Medicus KW - Promoter Regions, Genetic KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Humans KW - Electrophoretic Mobility Shift Assay KW - Molecular Sequence Data KW - Eosinophils -- metabolism KW - Chromatin Immunoprecipitation KW - RNA, Small Interfering -- pharmacology KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Umbilical Cord KW - GATA1 Transcription Factor -- physiology KW - Gene Expression Regulation, Enzymologic KW - Eosinophil-Derived Neurotoxin -- metabolism KW - GATA2 Transcription Factor -- physiology KW - Leukemia, Promyelocytic, Acute -- metabolism KW - Leukemia, Promyelocytic, Acute -- genetics KW - Leukemia, Promyelocytic, Acute -- pathology KW - Eosinophil-Derived Neurotoxin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67202150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=GATA+transcription+factors+regulate+the+expression+of+the+human+eosinophil-derived+neurotoxin+%28RNase+2%29+gene.&rft.au=Qiu%2C+Zhijun%3BDyer%2C+Kimberly+D%3BXie%2C+Zhihui%3BR%C3%A5dinger%2C+Madeleine%3BRosenberg%2C+Helene+F&rft.aulast=Qiu&rft.aufirst=Zhijun&rft.date=2009-05-08&rft.volume=284&rft.issue=19&rft.spage=13099&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M807307200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-21 N1 - Date created - 2009-05-04 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - FJ785402; GENBANK N1 - SuppNotes - Cited By: Nat Genet. 1995 Jun;10(2):219-23 [7663519] Curr Mol Med. 2008 Sep;8(6):585-90 [18781965] J Biol Chem. 1996 May 24;271(21):12387-93 [8647842] Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12370-5 [8901588] J Biol Chem. 1997 Jan 17;272(3):1665-9 [8999843] Blood. 1998 Mar 15;91(6):2126-32 [9490699] Curr Opin Hematol. 1999 May;6(3):164-8 [10226737] Blood. 1999 Aug 15;94(4):1429-39 [10438731] Blood. 1999 Oct 1;94(7):2333-42 [10498605] Semin Cell Dev Biol. 2005 Feb;16(1):129-36 [15659347] Ann N Y Acad Sci. 2005 Jun;1044:142-58 [15958708] Int J Hematol. 2005 Jun;81(5):378-84 [16158817] Int J Biochem Cell Biol. 2006 Jan;38(1):6-11 [16095949] Annu Rev Immunol. 2006;24:147-74 [16551246] Genes Dev. 2006 Nov 1;20(21):3010-21 [17079688] Blood. 2009 Jan 8;113(2):317-27 [18832658] J Leukoc Biol. 1999 Oct;66(4):683-8 [10534126] J Biol Chem. 2000 Mar 31;275(13):9425-32 [10734088] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4701-6 [10758160] J Allergy Clin Immunol. 2001 Aug;108(2 Suppl):S72-6 [11498676] Cell Mol Life Sci. 2001 Dec;58(14):2008-17 [11814053] Curr Opin Hematol. 2002 Mar;9(2):93-100 [11844990] J Exp Med. 2002 Jun 3;195(11):1379-86 [12045236] J Exp Med. 2002 Jun 3;195(11):1387-95 [12045237] J Exp Med. 2002 Jun 3;195(11):F43-7 [12045250] J Allergy Clin Immunol. 2002 Oct;110(4):553-64 [12373260] Acta Haematol. 2002;108(4):237-45 [12432220] Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8811-6 [12857954] Am J Respir Med. 2003;2(3):245-59 [14720006] Mamm Genome. 2004 Feb;15(2):126-34 [15058383] Proc Natl Acad Sci U S A. 1981 Aug;78(8):5165-9 [6946462] J Allergy Clin Immunol. 1982 Nov;70(5):361-6 [7130551] J Exp Med. 1984 Jul 1;160(1):179-96 [6588134] Proc Natl Acad Sci U S A. 1989 Jun;86(12):4460-4 [2734298] Genes Dev. 1991 Jun;5(6):919-31 [2044960] Nucleic Acids Res. 1991 Oct 11;19(19):5285-91 [1656391] Nucleic Acids Res. 1992 Apr 11;20(7):1812 [1579480] Blood. 1993 Jun 15;81(12):3234-41 [8507862] Mol Cell Biol. 1993 Jul;13(7):4011-22 [8321208] Genes Dev. 1994 May 15;8(10):1184-97 [7926723] Exp Hematol. 1995 Feb;23(2):99-107 [7828675] Genes Dev. 1995 May 15;9(10):1250-62 [7758949] J Leukoc Biol. 1995 Jul;58(1):49-54 [7616105] J Immunol. 2007 Aug 1;179(3):1693-9 [17641035] BMC Mol Biol. 2007;8:89 [17927842] J Exp Med. 2008 Jan 21;205(1):79-90 [18195069] J Leukoc Biol. 2008 May;83(5):1079-87 [18211964] Curr Pharm Biotechnol. 2008 Jun;9(3):135-40 [18673278] J Biol Chem. 1995 Sep 15;270(37):21539-44 [7665566] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M807307200 ER - TY - JOUR T1 - Crystal Structures of the Histo-Aspartic Protease (HAP) from Plasmodium falciparum AN - 20523367; 9211246 AB - The structures of recombinant histo-aspartic protease (HAP) from malaria-causing parasite Plasmodium falciparum as apoenzyme and in complex with two inhibitors, pepstatin A and KNI-10006, were solved at 2.5-, 3.3-, and 3.05-A resolutions, respectively. In the apoenzyme crystals, HAP forms a tight dimer not seen previously in any aspartic protease. The interactions between the monomers affect the conformation of two flexible loops, the functionally important ''flap'' (residues 70-83) and its structural equivalent in the C-terminal domain (residues 238-245), as well as the orientation of helix 225-235. The flap is found in an open conformation in the apoenzyme. Unexpectedly, the active site of the apoenzyme contains a zinc ion tightly bound to His32 and Asp215 from one monomer and to Glu278A from the other monomer, with the coordination of Zn resembling that seen in metalloproteases. The flap is closed in the structure of the pepstatin A complex, whereas it is open in the complex with KNI-10006. Although the binding mode of pepstatin A is significantly different from that in other pepsin-like aspartic proteases, its location in the active site makes unlikely the previously proposed hypothesis that HAP is a serine protease. The binding mode of KNI-10006 is unusual compared with the binding of other inhibitors from the KNI series to aspartic proteases. The novel features of the HAP active site could facilitate design of specific inhibitors used in the development of antimalarial drugs. JF - Journal of Molecular Biology AU - Bhaumik, P AU - Xiao, H AU - Parr, CL AU - Kiso, Y AU - Gustchina, A AU - Yada, R Y AU - Wlodawer, A AD - Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA, alla@ncifcrf.gov Y1 - 2009/05/08/ PY - 2009 DA - 2009 May 08 SP - 520 EP - 540 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 388 IS - 3 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Parasites KW - Serine proteinase KW - Heavy metals KW - Apoenzymes KW - Drug development KW - Plasmodium falciparum KW - Crystals KW - Public health KW - Monomers KW - Metalloproteinase KW - Recombinants KW - aspartic endopeptidase KW - Zinc KW - Crystal structure KW - Inhibitors KW - Drugs KW - Conformation KW - K 03340:Effects of Physical & Chemical Factors KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20523367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Crystal+Structures+of+the+Histo-Aspartic+Protease+%28HAP%29+from+Plasmodium+falciparum&rft.au=Bhaumik%2C+P%3BXiao%2C+H%3BParr%2C+CL%3BKiso%2C+Y%3BGustchina%2C+A%3BYada%2C+R+Y%3BWlodawer%2C+A&rft.aulast=Bhaumik&rft.aufirst=P&rft.date=2009-05-08&rft.volume=388&rft.issue=3&rft.spage=520&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2009.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Recombinants; Parasites; Heavy metals; Inhibitors; Drugs; Public health; Metalloproteinase; Monomers; aspartic endopeptidase; Serine proteinase; Apoenzymes; Zinc; Crystal structure; Drug development; Crystals; Conformation; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.jmb.2009.03.011 ER - TY - JOUR T1 - ETS2 Regulating Neurodegenerative Signaling Pathway of Human Neuronal (SH-SY5Y) Cells Exposed to Single and Repeated Low-Dose Sarin (GB) AN - 754548299; 13301042 AB - The mechanistic understanding of low-level sarin-induced neurotoxicity after single or repeated doses has yet to be explored at a cellular level. Using the microarray (Affymetrix-GeneChips) transcription profiling approach, the present study examined gene expression in human SH-SY5Y cells exposed to single (3 and 24 h) or repeated (2 X 24 h) doses of sarin (5 *mg/mL) to delineate the possible mechanism. Two hundred twenty-four genes whose expression was significantly (P < 0.01) altered by at least 3-fold were selected by GeneSpringGX analysis. The comparative gene expression data confirmed the transcriptional changes to be related to dose and exposure time of sarin. The effect of a single noncytotoxic sarin dose on gene transcription was variable, whereas repeated doses over 48 h persistently down-regulated genes linked to neurodegenerative mechanisms. Thirty persistently altered genes were validated using real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Similar qRT-PCR profiles obtained in sarin-treated SH-SY5Y and HCN-1A cells confirmed the cell-independent alterations in expression levels. Genes (ETS2, APOE, PSEN1, DDC, and CD9) implicated mainly in the regulation of sarin-induced neuropathogenesis were further confirmed by Western blot and double-immunofluorescence assays. The regulome pathway suggests a new feasible mechanism by which sarin increases ETS2 expression and takes control over other genes involved in the neurodegenerative pathway. The overall data delineate an in vitro experimental model suitable for studying the neuropathology of cells and may provide novel insights into therapeutic interventions. JF - Chemical Research in Toxicology AU - Pachiappan, Arjunan AU - Thwin, Maung Maung AU - Keong, Loke Weng AU - Lee, Fook Kay AU - Manikandan, Jayapal AU - Sivakumar, Viswanathan AU - Gopalakrishnakone, Ponnampalam AD - Departments of Anatomy and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, DSO National Laboratories, Singapore 118230, and Porter Neuroscience Research Center, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2009/05/07/ PY - 2009 DA - 2009 May 07 SP - 990 EP - 996 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA VL - 22 IS - 6 SN - 0893-228X, 0893-228X KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Western blotting KW - Data processing KW - Apolipoprotein E KW - Neuropathogenesis KW - Therapeutic applications KW - Transcription KW - DNA microarrays KW - CD9 antigen KW - Gene expression KW - Ets-2 protein KW - Neurotoxicity KW - Sarin KW - Neuropathology KW - Signal transduction KW - X 24360:Metals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754548299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=ETS2+Regulating+Neurodegenerative+Signaling+Pathway+of+Human+Neuronal+%28SH-SY5Y%29+Cells+Exposed+to+Single+and+Repeated+Low-Dose+Sarin+%28GB%29&rft.au=Pachiappan%2C+Arjunan%3BThwin%2C+Maung+Maung%3BKeong%2C+Loke+Weng%3BLee%2C+Fook+Kay%3BManikandan%2C+Jayapal%3BSivakumar%2C+Viswanathan%3BGopalakrishnakone%2C+Ponnampalam&rft.aulast=Pachiappan&rft.aufirst=Arjunan&rft.date=2009-05-07&rft.volume=22&rft.issue=6&rft.spage=990&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx8003467 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Western blotting; Data processing; Apolipoprotein E; Neuropathogenesis; Transcription; Therapeutic applications; DNA microarrays; Gene expression; CD9 antigen; Ets-2 protein; Neurotoxicity; Sarin; Neuropathology; Signal transduction DO - http://dx.doi.org/10.1021/tx8003467 ER - TY - JOUR T1 - Hypusine-containing protein eIF5A promotes translation elongation AN - 20600266; 9310141 AB - Translation elongation factors facilitate protein synthesis by the ribosome. Previous studies identified two universally conserved translation elongation factors, EF-Tu in bacteria (known as eEF1A in eukaryotes) and EF-G (eEF2), which deliver aminoacyl-tRNAs to the ribosome and promote ribosomal translocation, respectively. The factor eIF5A (encoded by HYP2 and ANB1 in Saccharomyces cerevisiae), the sole protein in eukaryotes and archaea to contain the unusual amino acid hypusine (N super(epsilon)-(4- amino-2-hydroxybutyl)lysine), was originally identified based on its ability to stimulate the yield (endpoint) of methionyl-puromycin synthesis-a model assay for first peptide bond synthesis thought to report on certain aspects of translation initiation. Hypusine is required for eIF5A to associate with ribosomes and to stimulate methionyl-puromycin synthesis. Because eIF5A did not stimulate earlier steps of translation initiation, and depletion of eIF5A in yeast only modestly impaired protein synthesis, it was proposed that eIF5A function was limited to stimulating synthesis of the first peptide bond or that eIF5A functioned on only a subset of cellular messenger RNAs. However, the precise cellular role of eIF5A is unknown, and the protein has also been linked to mRNA decay, including the nonsense-mediated mRNA decay pathway, and to nucleocytoplasmic transport. Here we use molecular genetic and biochemical studies to show that eIF5A promotes translation elongation. Depletion or inactivation of eIF5A in the yeast S. cerevisiae resulted in the accumulation of polysomes and an increase in ribosomal transit times. Addition of recombinant eIF5A from yeast, but not a derivative lacking hypusine, enhanced the rate of tripeptide synthesis in vitro. Moreover, inactivation of eIF5A mimicked the effects of the eEF2 inhibitor sordarin, indicating that eIF5A might function together with eEF2 to promote ribosomal translocation. Because eIF5A is a structural homologue of the bacterial protein EF-P, we propose that eIF5A/EF-P is a universally conserved translation elongation factor. JF - Nature AU - Saini, Preeti AU - Eyler, Daniel E AU - Green, Rachel AU - Dever, Thomas E AD - Laboratory of Gene Regulation and Development, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2009/05/07/ PY - 2009 DA - 2009 May 07 SP - 118 EP - 121 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 458 IS - 7243 SN - 0028-0836, 0028-0836 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Polyribosomes KW - mRNA turnover KW - Protein biosynthesis KW - Amino acids KW - Archaea KW - Translation initiation KW - nonsense-mediated mRNA decay KW - Ribosomes KW - Saccharomyces cerevisiae KW - mRNA KW - Translation elongation KW - Translocation KW - J 02330:Biochemistry KW - A 01310:Products of Microorganisms KW - N 14830:RNA KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20600266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Hypusine-containing+protein+eIF5A+promotes+translation+elongation&rft.au=Saini%2C+Preeti%3BEyler%2C+Daniel+E%3BGreen%2C+Rachel%3BDever%2C+Thomas+E&rft.aulast=Saini&rft.aufirst=Preeti&rft.date=2009-05-07&rft.volume=458&rft.issue=7243&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature08034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Polyribosomes; mRNA turnover; Amino acids; Protein biosynthesis; Translation initiation; Translation elongation; nonsense-mediated mRNA decay; Ribosomes; Translocation; mRNA; Archaea; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1038/nature08034 ER - TY - CPAPER T1 - Mentoring & Finding a Niche T2 - 69th Annual Meeting of the Society for Investigative Dermatology (SID 2009) AN - 42109021; 5138304 JF - 69th Annual Meeting of the Society for Investigative Dermatology (SID 2009) AU - Katz, Stephen Y1 - 2009/05/06/ PY - 2009 DA - 2009 May 06 KW - Niches KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42109021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2009%29&rft.atitle=Mentoring+%26amp%3B+Finding+a+Niche&rft.au=Katz%2C+Stephen&rft.aulast=Katz&rft.aufirst=Stephen&rft.date=2009-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sidnet.org/Annual%20Meeting/2009%20Meeting%20Program%20-%20 Final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Applying different control approaches for resources with high and low utilisation: a case study of the production of complex products with stochastic processing times AN - 20592586; 9295896 AB - Research on dispatching rules has mainly focused upon deterministic job shop situations or small assembly environments and has ignored operational factors. Recent work has examined the relative performance of dispatching rules in companies that produce several families of complex products with stochastic processing times. Previous work has used common control policies for all resources. In practice, it is common for there to be a wide variation in the utilisation of machines. The Optimised Production Technology (OPT) philosophy suggests that particular attention should be paid to bottleneck resources. This paper investigates the effect of applying different manufacturing control approaches for resources with high and low utilisation. The work uses data obtained from an Engineer-To-Order (ETO) capital goods company that produces complex products in low volume. Processing times are assumed to be normally distributed. A range of scenarios are considered in which an increasing proportion of resources are considered to be 'bottlenecks'. The results show that the mean tardiness of products decreases significantly when the highly utilised machines are carefully controlled. However, there is only marginal benefit in carefully controlling the other machines. JF - International Journal of Technology Management AU - Hicks, Christian AU - Pongcharoen, Pupong AD - Newcastle University Business School, Newcastle upon Tyne NEI 7RU, UK. Y1 - 2009/05/04/ PY - 2009 DA - 2009 May 04 SP - 202 EP - 218 PB - Inderscience Publishers Ltd., PO Box 735 VL - 48 IS - 2 SN - 0267-5730, 0267-5730 KW - Sustainability Science Abstracts KW - MANAGEMENT JOURNALS KW - Policy and Organisational Management KW - Technology Management KW - case studies KW - Technology KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20592586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Technology+Management&rft.atitle=Applying+different+control+approaches+for+resources+with+high+and+low+utilisation%3A+a+case+study+of+the+production+of+complex+products+with+stochastic+processing+times&rft.au=Hicks%2C+Christian%3BPongcharoen%2C+Pupong&rft.aulast=Hicks&rft.aufirst=Christian&rft.date=2009-05-04&rft.volume=48&rft.issue=2&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Technology+Management&rft.issn=02675730&rft_id=info:doi/10.1504%2FIJTM.2009.024916 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - case studies; Technology DO - http://dx.doi.org/10.1504/IJTM.2009.024916 ER - TY - CPAPER T1 - Identification of Microbial DNA in Chorioretinal Lesions Associated With Chronic Granulomatous Disease T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42584487; 5479582 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Herzlich, A AU - Shen, D AU - Yeh, S AU - Holland, S AU - Chan, C Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Lesions KW - Chronic granulomatous disease KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42584487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Identification+of+Microbial+DNA+in+Chorioretinal+Lesions+Associated+With+Chronic+Granulomatous+Disease&rft.au=Herzlich%2C+A%3BShen%2C+D%3BYeh%2C+S%3BHolland%2C+S%3BChan%2C+C&rft.aulast=Herzlich&rft.aufirst=A&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lateral Induction of Jagged1 Through Jagged1-Notch2 Signaling During FGF-Induced Differentiation of Lens Epithelial Explants T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42583878; 5477996 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Saravanamuthu, S AU - Gao, C AU - Zelenka, P Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Signal transduction KW - Differentiation KW - Explants KW - Jagged1 protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42583878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Lateral+Induction+of+Jagged1+Through+Jagged1-Notch2+Signaling+During+FGF-Induced+Differentiation+of+Lens+Epithelial+Explants&rft.au=Saravanamuthu%2C+S%3BGao%2C+C%3BZelenka%2C+P&rft.aulast=Saravanamuthu&rft.aufirst=S&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Behavior in Retinal Microglia Is Regulated by CX3CR1 Signaling T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42581958; 5476645 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Wong, W T AU - Liang, K J AU - Lee, J AU - Wang, Y D AU - Fariss, R N Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Signal transduction KW - CX3CR1 protein KW - Retina KW - Microglia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42581958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Dynamic+Behavior+in+Retinal+Microglia+Is+Regulated+by+CX3CR1+Signaling&rft.au=Wong%2C+W+T%3BLiang%2C+K+J%3BLee%2C+J%3BWang%2C+Y+D%3BFariss%2C+R+N&rft.aulast=Wong&rft.aufirst=W&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Retinal Vascular Repair and Neovascularization Are Not Dependent on CX3CR1 Signaling in a Model of Ischemic Retinopathy T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42581625; 5476519 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Zhao, L AU - Ma, W. AU - Fariss, R N AU - Wong, W T Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Ischemia KW - Signal transduction KW - Retinopathy KW - CX3CR1 protein KW - Retina KW - Vascular system KW - Vascularization KW - Models KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42581625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Retinal+Vascular+Repair+and+Neovascularization+Are+Not+Dependent+on+CX3CR1+Signaling+in+a+Model+of+Ischemic+Retinopathy&rft.au=Zhao%2C+L%3BMa%2C+W.%3BFariss%2C+R+N%3BWong%2C+W+T&rft.aulast=Zhao&rft.aufirst=L&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic variation in individuals and populations T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42581032; 5476617 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Wojciechowski, R Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Genetic diversity KW - Population genetics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42581032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Genetic+variation+in+individuals+and+populations&rft.au=Wojciechowski%2C+R&rft.aulast=Wojciechowski&rft.aufirst=R&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monosaccharide Composition and Asparagine-Linked Oligosaccharide Profile of Interphotoreceptor Retinoid-Binding Protein T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42580310; 5476572 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Duncan, T AU - Kutty, R K AU - Samuel, W AU - Redmond, T M Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Monosaccharides KW - Oligosaccharides KW - Interphotoreceptor retinoid-binding protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42580310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Monosaccharide+Composition+and+Asparagine-Linked+Oligosaccharide+Profile+of+Interphotoreceptor+Retinoid-Binding+Protein&rft.au=Duncan%2C+T%3BKutty%2C+R+K%3BSamuel%2C+W%3BRedmond%2C+T+M&rft.aulast=Duncan&rft.aufirst=T&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Advanced AMD and Variants in Elements of Omega-3 Lipid-Associated Signaling Pathways T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42579965; 5476708 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - SanGiovanni, J P AU - Clemons, T E AU - Agron, E AU - Vora, A AU - Chew, E Y Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Signal transduction KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42579965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Advanced+AMD+and+Variants+in+Elements+of+Omega-3+Lipid-Associated+Signaling+Pathways&rft.au=SanGiovanni%2C+J+P%3BClemons%2C+T+E%3BAgron%2C+E%3BVora%2C+A%3BChew%2C+E+Y&rft.aulast=SanGiovanni&rft.aufirst=J&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Expression of Tissue Factor in Eyes With Age-Related Macular Degeneration T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42579348; 5476551 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Cho, Y AU - Shen, D AU - Parver, L M AU - Tuo, J AU - Rickles, F R Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Macular degeneration KW - Age KW - Tissue factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42579348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=The+Expression+of+Tissue+Factor+in+Eyes+With+Age-Related+Macular+Degeneration&rft.au=Cho%2C+Y%3BShen%2C+D%3BParver%2C+L+M%3BTuo%2C+J%3BRickles%2C+F+R&rft.aulast=Cho&rft.aufirst=Y&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - C/EBP? Regulates the Neuronal Differentiation and the Expression of Insulin-Like Growth Factor Binding Protein-5 in Human Retinal Pigment Epithelial (RPE) Cells Induced by N-(4- Hydroxyphenyl)Retinamide T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42578543; 5476489 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Samuel, W AU - Kutty, R K AU - Vijayasarathy, C AU - Pascual, I AU - Duncan, T AU - Redmond, T M Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Pigments KW - Growth factors KW - Retina KW - CCAAT/enhancer-binding protein KW - Differentiation KW - Insulin-like growth factors KW - Growth KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42578543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=C%2FEBP%3F+Regulates+the+Neuronal+Differentiation+and+the+Expression+of+Insulin-Like+Growth+Factor+Binding+Protein-5+in+Human+Retinal+Pigment+Epithelial+%28RPE%29+Cells+Induced+by+N-%284-+Hydroxyphenyl%29Retinamide&rft.au=Samuel%2C+W%3BKutty%2C+R+K%3BVijayasarathy%2C+C%3BPascual%2C+I%3BDuncan%2C+T%3BRedmond%2C+T+M&rft.aulast=Samuel&rft.aufirst=W&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The N-Terminal Extensions in Homo- and Hetero-Associations of ?-Crystallins T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42576971; 5475686 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Dolinska, M B AU - Chan, M P AU - Sergeev, Y V AU - Wingfield, P T AU - Hejtmancik, F J Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42576971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=The+N-Terminal+Extensions+in+Homo-+and+Hetero-Associations+of+%3F-Crystallins&rft.au=Dolinska%2C+M+B%3BChan%2C+M+P%3BSergeev%2C+Y+V%3BWingfield%2C+P+T%3BHejtmancik%2C+F+J&rft.aulast=Dolinska&rft.aufirst=M&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spontaneous Uveitis in IRBP T Cell Receptor Transgenic Mice T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42576731; 5476642 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Horai, R AU - Agarwal, R K AU - Yazdani, A T AU - Silver, P B AU - Natarajan, K AU - Wang, P AU - Chan, C.-C. AU - Caspi, R R Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Mice KW - T-cell receptor KW - Uveitis KW - Interphotoreceptor retinoid-binding protein KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42576731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Spontaneous+Uveitis+in+IRBP+T+Cell+Receptor+Transgenic+Mice&rft.au=Horai%2C+R%3BAgarwal%2C+R+K%3BYazdani%2C+A+T%3BSilver%2C+P+B%3BNatarajan%2C+K%3BWang%2C+P%3BChan%2C+C.-C.%3BCaspi%2C+R+R&rft.aulast=Horai&rft.aufirst=R&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IFNg Regulates Fluid Transport Across Human RPE: Role of CFTR T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42575936; 5475429 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Li, R. AU - Maminishkis, A AU - Banzon, T AU - Jalickee, S AU - Chen, S AU - Wan, Q AU - Miller, S S Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42575936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=IFNg+Regulates+Fluid+Transport+Across+Human+RPE%3A+Role+of+CFTR&rft.au=Li%2C+R.%3BMaminishkis%2C+A%3BBanzon%2C+T%3BJalickee%2C+S%3BChen%2C+S%3BWan%2C+Q%3BMiller%2C+S+S&rft.aulast=Li&rft.aufirst=R.&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Up-Regulation of WIF1 Gene Expression by Over-Expression of Olfactomedin 1 T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42575674; 5476483 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Sultana, A AU - Lee, H.-S. AU - Nakaya, N AU - Tomarev, S Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Gene expression KW - Olfactomedin KW - Overexpression KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42575674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Up-Regulation+of+WIF1+Gene+Expression+by+Over-Expression+of+Olfactomedin+1&rft.au=Sultana%2C+A%3BLee%2C+H.-S.%3BNakaya%2C+N%3BTomarev%2C+S&rft.aulast=Sultana&rft.aufirst=A&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photo-Damage Generates 7-Ketoand 7-Hydroxycholesterol in the Rat Retina via a Free Radical-Mediated Mechanism T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42575447; 5478837 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Rodriguez, I AU - Fliesler, S Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42575447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Photo-Damage+Generates+7-Ketoand+7-Hydroxycholesterol+in+the+Rat+Retina+via+a+Free+Radical-Mediated+Mechanism&rft.au=Rodriguez%2C+I%3BFliesler%2C+S&rft.aulast=Rodriguez&rft.aufirst=I&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Severe X-Linked Retinoschisis Phenotype From a Null RS1 Mutation (354del1ins18) T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42575246; 5477760 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Vijayasarathy, C AU - Caruso, R AU - Zeng, Y AU - Ziccardi, L AU - Smaoui, N AU - Sieving, P Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Mutation KW - Retinoschisis KW - X chromosome KW - Phenotypes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42575246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Severe+X-Linked+Retinoschisis+Phenotype+From+a+Null+RS1+Mutation+%28354del1ins18%29&rft.au=Vijayasarathy%2C+C%3BCaruso%2C+R%3BZeng%2C+Y%3BZiccardi%2C+L%3BSmaoui%2C+N%3BSieving%2C+P&rft.aulast=Vijayasarathy&rft.aufirst=C&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIH-CSR Peer Review T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42575152; 5477888 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Etcheberrigaray, R Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Reviews KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42575152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=NIH-CSR+Peer+Review&rft.au=Etcheberrigaray%2C+R&rft.aulast=Etcheberrigaray&rft.aufirst=R&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hambright T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42574868; 5478798 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - D., AU - Nasonkin, I AU - Park, K -Y AU - McKay, R AU - Swaroop, A Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42574868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Hambright&rft.au=D.%2C%3BNasonkin%2C+I%3BPark%2C+K+-Y%3BMcKay%2C+R%3BSwaroop%2C+A&rft.aulast=D.&rft.aufirst=&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apoferritin Is Maintaining the Native Conformation of Citrate Synthase in vitro T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42574113; 5477014 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Sergeev, Y V AU - Hejtmancik, J F Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Conformation KW - Apoferritin KW - Citric acid KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42574113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Apoferritin+Is+Maintaining+the+Native+Conformation+of+Citrate+Synthase+in+vitro&rft.au=Sergeev%2C+Y+V%3BHejtmancik%2C+J+F&rft.aulast=Sergeev&rft.aufirst=Y&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular and Functional Changes Associated With Normal Aging in the Retina T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42574074; 5479105 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Chang, J AU - Parapuram, S AU - Khanna, R AU - Brooks, M AU - Cojocaru, R AU - Khan, N AU - Nellissery, J AU - Roger, J AU - Swaroop, A Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Aging KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42574074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Molecular+and+Functional+Changes+Associated+With+Normal+Aging+in+the+Retina&rft.au=Chang%2C+J%3BParapuram%2C+S%3BKhanna%2C+R%3BBrooks%2C+M%3BCojocaru%2C+R%3BKhan%2C+N%3BNellissery%2C+J%3BRoger%2C+J%3BSwaroop%2C+A&rft.aulast=Chang&rft.aufirst=J&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Search for Interactors of Retinal Degeneration 3 (RD3) T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42573297; 5478149 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Krauth, D AU - Friedman, J AU - Cuzcano, A AU - Swaroop, A Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Retinal degeneration KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42573297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Search+for+Interactors+of+Retinal+Degeneration+3+%28RD3%29&rft.au=Krauth%2C+D%3BFriedman%2C+J%3BCuzcano%2C+A%3BSwaroop%2C+A&rft.aulast=Krauth&rft.aufirst=D&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 7-Ketocholesterol Induces VEGF and Other Cytokines via Multiple Inflammatory Pathways T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42572008; 5475421 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Larrayoz, I M AU - Pascual, I AU - Lee, J W AU - Rodriguez, I R Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Cytokines KW - Inflammation KW - Vascular endothelial growth factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42572008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=7-Ketocholesterol+Induces+VEGF+and+Other+Cytokines+via+Multiple+Inflammatory+Pathways&rft.au=Larrayoz%2C+I+M%3BPascual%2C+I%3BLee%2C+J+W%3BRodriguez%2C+I+R&rft.aulast=Larrayoz&rft.aufirst=I&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ophthalmic Manifestations of the Inherited Bone Marrow Failure Syndromes T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42571691; 5475893 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Tsilou, E T AU - Giri, N AU - Weinstein, S AU - Mueller, C AU - Savage, S AU - Alter, B P Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Bone marrow KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42571691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Ophthalmic+Manifestations+of+the+Inherited+Bone+Marrow+Failure+Syndromes&rft.au=Tsilou%2C+E+T%3BGiri%2C+N%3BWeinstein%2C+S%3BMueller%2C+C%3BSavage%2C+S%3BAlter%2C+B+P&rft.aulast=Tsilou&rft.aufirst=E&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome-Wide Analysis of Target Genes for Nrl in Developing and Mature Retina T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42571578; 5479093 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Hao, H AU - Kim, D AU - Brooks, M AU - Khanna, R AU - Othman, M AU - Johnson, K AU - Cojocaru, R AU - Swaroop, A Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42571578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Genome-Wide+Analysis+of+Target+Genes+for+Nrl+in+Developing+and+Mature+Retina&rft.au=Hao%2C+H%3BKim%2C+D%3BBrooks%2C+M%3BKhanna%2C+R%3BOthman%2C+M%3BJohnson%2C+K%3BCojocaru%2C+R%3BSwaroop%2C+A&rft.aulast=Hao&rft.aufirst=H&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SUMOylation of Neural Retina Leucine Zipper (NRL) Is Necessary for Rod Photoreceptor Differentiation T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42570946; 5477620 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Roger, J AU - Nellissery, J AU - Kim, D AU - Kanda, A AU - Swaroop, A Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Leucine zipper proteins KW - Retina KW - Photoreceptors KW - Differentiation KW - SUMO protein KW - Leucine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42570946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=SUMOylation+of+Neural+Retina+Leucine+Zipper+%28NRL%29+Is+Necessary+for+Rod+Photoreceptor+Differentiation&rft.au=Roger%2C+J%3BNellissery%2C+J%3BKim%2C+D%3BKanda%2C+A%3BSwaroop%2C+A&rft.aulast=Roger&rft.aufirst=J&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simvastatin Affects Viability, Morphology and Phagocytosis of Human Cells in Culture T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42570800; 5477018 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Sui, R AU - Gordiyenko, N AU - Strunnikova, N AU - Zhi, C AU - MacDonald, I Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Morphology KW - Cell culture KW - Simvastatin KW - Phagocytosis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42570800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Simvastatin+Affects+Viability%2C+Morphology+and+Phagocytosis+of+Human+Cells+in+Culture&rft.au=Sui%2C+R%3BGordiyenko%2C+N%3BStrunnikova%2C+N%3BZhi%2C+C%3BMacDonald%2C+I&rft.aulast=Sui&rft.aufirst=R&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapeutic Targeting of STAT3 Pathways of Macrophage and Th17 cells T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42569892; 5474358 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Lee, Y AU - Egwuagu, C E Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Macrophages KW - Stat3 protein KW - Helper cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42569892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Therapeutic+Targeting+of+STAT3+Pathways+of+Macrophage+and+Th17+cells&rft.au=Lee%2C+Y%3BEgwuagu%2C+C+E&rft.aulast=Lee&rft.aufirst=Y&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Is Essential for Recruitment of Active Src to Focal Adhesions T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42569459; 5476160 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Q. Pan, AU - Parthasarathy, A AU - Zelenka, P Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Adhesion KW - Recruitment KW - Src protein KW - Cyclin-dependent kinase 5 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42569459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Cdk5+Is+Essential+for+Recruitment+of+Active+Src+to+Focal+Adhesions&rft.au=Q.+Pan%2C%3BParthasarathy%2C+A%3BZelenka%2C+P&rft.aulast=Q.+Pan&rft.aufirst=&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanistic Insight into the Interaction of Pigment-epithelium Derived Factor and Its Receptor PEDF-R for Retinal Cell Survival T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42569050; 5475909 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Subramanian, P AU - Locatelli-Hoops, S AU - Choxi, S AU - Seigel, G M AU - Becerra, S P Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Survival KW - Retina KW - Cell survival KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42569050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Mechanistic+Insight+into+the+Interaction+of+Pigment-epithelium+Derived+Factor+and+Its+Receptor+PEDF-R+for+Retinal+Cell+Survival&rft.au=Subramanian%2C+P%3BLocatelli-Hoops%2C+S%3BChoxi%2C+S%3BSeigel%2C+G+M%3BBecerra%2C+S+P&rft.aulast=Subramanian&rft.aufirst=P&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Daclizumab and Its Effect on Chronic Uveitic CME T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42568798; 5476254 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Nazemzadeh, M AU - Faia, L AU - Shah, R AU - Nussenblatt, R B AU - Sen, H N Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Environmental effects KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42568798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Daclizumab+and+Its+Effect+on+Chronic+Uveitic+CME&rft.au=Nazemzadeh%2C+M%3BFaia%2C+L%3BShah%2C+R%3BNussenblatt%2C+R+B%3BSen%2C+H+N&rft.aulast=Nazemzadeh&rft.aufirst=M&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell-Cell Junctions in a Cdk5- Deficient Corneal Epithelial Cell Line T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42568496; 5476165 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Saravanan, A P AU - Gao, C Y AU - Tripathi, B AU - Zelenka, P Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Epithelial cells KW - Cornea KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42568496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Cell-Cell+Junctions+in+a+Cdk5-+Deficient+Corneal+Epithelial+Cell+Line&rft.au=Saravanan%2C+A+P%3BGao%2C+C+Y%3BTripathi%2C+B%3BZelenka%2C+P&rft.aulast=Saravanan&rft.aufirst=A&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pro-Angiogenic Effect of IFN? Is Dependent on the PI3k/mTOR/Translational Pathway T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42568178; 5474719 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Liu, B AU - Li, Z. AU - Faia, L AU - Nussenblatt, R Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Translation KW - 1-Phosphatidylinositol 3-kinase KW - Interferon KW - TOR protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42568178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Pro-Angiogenic+Effect+of+IFN%3F+Is+Dependent+on+the+PI3k%2FmTOR%2FTranslational+Pathway&rft.au=Liu%2C+B%3BLi%2C+Z.%3BFaia%2C+L%3BNussenblatt%2C+R&rft.aulast=Liu&rft.aufirst=B&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Choosing a Mentor in Residency T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42568143; 5474294 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Faia, L J Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42568143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Choosing+a+Mentor+in+Residency&rft.au=Faia%2C+L+J&rft.aulast=Faia&rft.aufirst=L&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ASCC3L1 Gene Mutation in a Chinese Family With Autosomal Dominant Retinitis Pigmentosa T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42567366; 5475876 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Li, N. AU - Han, M AU - Jiao, X AU - MacDonald, I AU - Zhao, K AU - Hejtmancik, J Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Point mutation KW - Retinitis pigmentosa KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42567366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=ASCC3L1+Gene+Mutation+in+a+Chinese+Family+With+Autosomal+Dominant+Retinitis+Pigmentosa&rft.au=Li%2C+N.%3BHan%2C+M%3BJiao%2C+X%3BMacDonald%2C+I%3BZhao%2C+K%3BHejtmancik%2C+J&rft.aulast=Li&rft.aufirst=N.&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of Active Anterior Uveitis Associated With JIA Using Daclizumab T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42566578; 5476253 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Sen, H AU - Levy-Clarke, G AU - Faia, L J AU - Zhuqing, L AU - Barron, K S AU - Hammel, K AU - Nussenblatt, R B Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Uveitis KW - Jia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42566578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Treatment+of+Active+Anterior+Uveitis+Associated+With+JIA+Using+Daclizumab&rft.au=Sen%2C+H%3BLevy-Clarke%2C+G%3BFaia%2C+L+J%3BZhuqing%2C+L%3BBarron%2C+K+S%3BHammel%2C+K%3BNussenblatt%2C+R+B&rft.aulast=Sen&rft.aufirst=H&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NEI Workshop: Successful Grantsmanship in the Changing Environment at NIH T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42562995; 5475157 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - McNicol, L A Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Conferences KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42562995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=NEI+Workshop%3A+Successful+Grantsmanship+in+the+Changing+Environment+at+NIH&rft.au=McNicol%2C+L+A&rft.aulast=McNicol&rft.aufirst=L&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Single Nucleotide Polymorphism in 5-UTR of ERCC6 Confers Protection Against Age-Related Macular Degeneration T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42562937; 5475130 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Tuo, J AU - Cho, Y AU - Chew, E Y AU - Chan, C.-C. Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Macular degeneration KW - Single-nucleotide polymorphism KW - Age KW - Nucleotides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42562937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=A+Single+Nucleotide+Polymorphism+in+5-UTR+of+ERCC6+Confers+Protection+Against+Age-Related+Macular+Degeneration&rft.au=Tuo%2C+J%3BCho%2C+Y%3BChew%2C+E+Y%3BChan%2C+C.-C.&rft.aulast=Tuo&rft.aufirst=J&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship Between Photoreceptor Outer Segment Length and Visual Acuity in Diabetic Macular Edema T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42561782; 5474925 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Forooghian, F AU - Stetson, P F AU - Meyer, S A AU - Chew, E Y AU - Wong, W T AU - Cukras, C AU - Meyerle, C B AU - Ferris, III, F.L. Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Edema KW - Diabetes mellitus KW - Acuity KW - Photoreceptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42561782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Relationship+Between+Photoreceptor+Outer+Segment+Length+and+Visual+Acuity+in+Diabetic+Macular+Edema&rft.au=Forooghian%2C+F%3BStetson%2C+P+F%3BMeyer%2C+S+A%3BChew%2C+E+Y%3BWong%2C+W+T%3BCukras%2C+C%3BMeyerle%2C+C+B%3BFerris%2C+III%2C+F.L.&rft.aulast=Forooghian&rft.aufirst=F&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome Wide Association Study (GWAS) of Age-Related Macular Degeneration (AMD) T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42561421; 5475150 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Swaroop, A AU - Chen, W AU - Stambolian, D AU - Branham, K E AU - Othman, M AU - Chew, E Y AU - Heckenlively, J AU - Tosakulwong, N AU - Edwards, A O AU - Abecasis, G Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Macular degeneration KW - Genomes KW - Age KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42561421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Genome+Wide+Association+Study+%28GWAS%29+of+Age-Related+Macular+Degeneration+%28AMD%29&rft.au=Swaroop%2C+A%3BChen%2C+W%3BStambolian%2C+D%3BBranham%2C+K+E%3BOthman%2C+M%3BChew%2C+E+Y%3BHeckenlively%2C+J%3BTosakulwong%2C+N%3BEdwards%2C+A+O%3BAbecasis%2C+G&rft.aulast=Swaroop&rft.aufirst=A&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optical Coherence Tomography- Based Decision Making in Exudative Age-Related Macular Degeneration: Comparison of Timeversus Spectral-Domain Devices T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42560360; 5474612 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Cukras, C A AU - Wang, Y D AU - Meyerle, C B AU - Forooghian, F AU - Wong, W T Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Macular degeneration KW - Age KW - Decision making KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42560360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Optical+Coherence+Tomography-+Based+Decision+Making+in+Exudative+Age-Related+Macular+Degeneration%3A+Comparison+of+Timeversus+Spectral-Domain+Devices&rft.au=Cukras%2C+C+A%3BWang%2C+Y+D%3BMeyerle%2C+C+B%3BForooghian%2C+F%3BWong%2C+W+T&rft.aulast=Cukras&rft.aufirst=C&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Choroidal Neovascularization in the Setting of Uveitis: Clinical Features and Visual Outcomes T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AN - 42558105; 5475080 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology AU - Gottlieb, C AU - Faia, L J AU - Forooghian, F AU - Nussenblatt, R B AU - Sen, H N Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Uveitis KW - Vascularization KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42558105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.atitle=Choroidal+Neovascularization+in+the+Setting+of+Uveitis%3A+Clinical+Features+and+Visual+Outcomes&rft.au=Gottlieb%2C+C%3BFaia%2C+L+J%3BForooghian%2C+F%3BNussenblatt%2C+R+B%3BSen%2C+H+N&rft.aulast=Gottlieb&rft.aufirst=C&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recruitment Methods Employed in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial T2 - 30th Annual Meeting of the Society for Clinical Trials AN - 41785577; 5050420 JF - 30th Annual Meeting of the Society for Clinical Trials AU - Marcus, Pamela Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Ovarian carcinoma KW - Lung KW - Recruitment KW - Prostate KW - Ovarian cancer KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41785577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Meeting+of+the+Society+for+Clinical+Trials&rft.atitle=Recruitment+Methods+Employed+in+the+Prostate%2C+Lung%2C+Colorectal+and+Ovarian+Cancer+Screening+Trial&rft.au=Marcus%2C+Pamela&rft.aulast=Marcus&rft.aufirst=Pamela&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Meeting+of+the+Society+for+Clinical+Trials&rft.issn=&rft_id=info:doi/ L2 - http://sctweb.org/2009/SCT%20brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Participation in Substance Abuse Clinical Trials: Comparing Gender and Racial/Ethnic Groups T2 - 30th Annual Meeting of the Society for Clinical Trials AN - 41783449; 5050373 JF - 30th Annual Meeting of the Society for Clinical Trials AU - Rosa, Carmen Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Clinical trials KW - Sex KW - Ethnic groups KW - Substance abuse KW - Drug abuse KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41783449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Meeting+of+the+Society+for+Clinical+Trials&rft.atitle=Participation+in+Substance+Abuse+Clinical+Trials%3A+Comparing+Gender+and+Racial%2FEthnic+Groups&rft.au=Rosa%2C+Carmen&rft.aulast=Rosa&rft.aufirst=Carmen&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Meeting+of+the+Society+for+Clinical+Trials&rft.issn=&rft_id=info:doi/ L2 - http://sctweb.org/2009/SCT%20brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Achieving Continuity of Care and Enhancing Clinical Trials Success with the caBIG Clinical Trials Suite T2 - 30th Annual Meeting of the Society for Clinical Trials AN - 41762944; 5050518 JF - 30th Annual Meeting of the Society for Clinical Trials AU - Dyer, Bill Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Clinical trials KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41762944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Meeting+of+the+Society+for+Clinical+Trials&rft.atitle=Achieving+Continuity+of+Care+and+Enhancing+Clinical+Trials+Success+with+the+caBIG+Clinical+Trials+Suite&rft.au=Dyer%2C+Bill&rft.aulast=Dyer&rft.aufirst=Bill&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Meeting+of+the+Society+for+Clinical+Trials&rft.issn=&rft_id=info:doi/ L2 - http://sctweb.org/2009/SCT%20brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immuno-Modulatory Effect of Human Fetal Retinal Pigment Epithelial (fRPE) Cells on Monocyte Differentiation and Maturation T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40252639; 5214112 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Chakrabarty, S AU - Li, Z. AU - Maminishkis, A AU - Liu, B AU - Miller, S AU - Nussenblatt, R Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Pigments KW - Retina KW - Differentiation KW - Fetuses KW - Monocytes KW - Sexual maturity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40252639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Immuno-Modulatory+Effect+of+Human+Fetal+Retinal+Pigment+Epithelial+%28fRPE%29+Cells+on+Monocyte+Differentiation+and+Maturation&rft.au=Chakrabarty%2C+S%3BLi%2C+Z.%3BMaminishkis%2C+A%3BLiu%2C+B%3BMiller%2C+S%3BNussenblatt%2C+R&rft.aulast=Chakrabarty&rft.aufirst=S&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myocilin Triggers Cell Migration Through Regulation of FAK Activity T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40248909; 5211795 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Kwon, H.-S. AU - Tomarev, S Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Migration KW - Focal adhesion kinase KW - Cell migration KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40248909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Myocilin+Triggers+Cell+Migration+Through+Regulation+of+FAK+Activity&rft.au=Kwon%2C+H.-S.%3BTomarev%2C+S&rft.aulast=Kwon&rft.aufirst=H.-S.&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Selected Human Embryonic Stem Cell Lines for Differentiation to Retinal Cells and for Cell-Based Therapy T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40247572; 5213343 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Hambright, D AU - Nasonkin, I AU - Park, K -Y AU - McKay, R AU - Swaroop, A Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Stem cells KW - Retina KW - Differentiation KW - Embryo cells KW - Therapy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40247572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Evaluation+of+Selected+Human+Embryonic+Stem+Cell+Lines+for+Differentiation+to+Retinal+Cells+and+for+Cell-Based+Therapy&rft.au=Hambright%2C+D%3BNasonkin%2C+I%3BPark%2C+K+-Y%3BMcKay%2C+R%3BSwaroop%2C+A&rft.aulast=Hambright&rft.aufirst=D&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Specifically Affects Rho Activation Required for Myosin-Dependent Contraction and Stress Fiber Maintenance in Spreading Lens Epithelial Cells T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40246976; 5212962 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Tripathi, B AU - Zelenka, P Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Stress KW - Fibers KW - Epithelial cells KW - Cyclin-dependent kinase 5 KW - Cell migration KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40246976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Cdk5+Specifically+Affects+Rho+Activation+Required+for+Myosin-Dependent+Contraction+and+Stress+Fiber+Maintenance+in+Spreading+Lens+Epithelial+Cells&rft.au=Tripathi%2C+B%3BZelenka%2C+P&rft.aulast=Tripathi&rft.aufirst=B&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Receptor Therapy For The Treatment Of Primary Intraocular Lymphoma T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40244853; 5212996 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Nussenblatt, R Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Lymphoma KW - Therapy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40244853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Receptor+Therapy+For+The+Treatment+Of+Primary+Intraocular+Lymphoma&rft.au=Nussenblatt%2C+R&rft.aulast=Nussenblatt&rft.aufirst=R&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Up-Regulation of WIF1 Gene Expression by Over-Expression of Olfactomedin 1 T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40244044; 5211036 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Sultana, A AU - Lee, H.-S. AU - Nakaya, N AU - Tomarev, S Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Gene expression KW - Olfactomedin KW - Overexpression KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40244044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Up-Regulation+of+WIF1+Gene+Expression+by+Over-Expression+of+Olfactomedin+1&rft.au=Sultana%2C+A%3BLee%2C+H.-S.%3BNakaya%2C+N%3BTomarev%2C+S&rft.aulast=Sultana&rft.aufirst=A&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Gene Expression in Rod Photoreceptors: Purification of Nrlcontaining Transcriptional Complexes From Bovine Retina T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40242470; 5213637 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Yadav, S AU - Nellissery, J AU - Miyagi, M AU - Swaroop, A Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Gene expression KW - Retina KW - Purification KW - Photoreceptors KW - Transcription KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40242470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Regulation+of+Gene+Expression+in+Rod+Photoreceptors%3A+Purification+of+Nrlcontaining+Transcriptional+Complexes+From+Bovine+Retina&rft.au=Yadav%2C+S%3BNellissery%2C+J%3BMiyagi%2C+M%3BSwaroop%2C+A&rft.aulast=Yadav&rft.aufirst=S&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Retinal Neurotransmission Regulates Dendritic Morphology and Dynamic Behavior in Microglia T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40242081; 5214446 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Fontainhas, A AU - Liang, K AU - Mettu, P AU - Chen, S AU - Li, W. AU - Fariss, R AU - Wong, W Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Morphology KW - Retina KW - Microglia KW - Neurotransmission KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40242081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Retinal+Neurotransmission+Regulates+Dendritic+Morphology+and+Dynamic+Behavior+in+Microglia&rft.au=Fontainhas%2C+A%3BLiang%2C+K%3BMettu%2C+P%3BChen%2C+S%3BLi%2C+W.%3BFariss%2C+R%3BWong%2C+W&rft.aulast=Fontainhas&rft.aufirst=A&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapeutic Targeting of STAT3 Pathways of Macrophage and Th17 cells T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40241632; 5208909 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Lee, Y AU - Egwuagu, C Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Macrophages KW - Stat3 protein KW - Helper cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40241632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Therapeutic+Targeting+of+STAT3+Pathways+of+Macrophage+and+Th17+cells&rft.au=Lee%2C+Y%3BEgwuagu%2C+C&rft.aulast=Lee&rft.aufirst=Y&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Analysis of Fundus Autofluorescence Images Shows Short-Term Progression in Stargardt Disease T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40240469; 5214469 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Caruso, R AU - Zein, W AU - Cunningham, D AU - Rasband, W Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Quantitative analysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40240469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Quantitative+Analysis+of+Fundus+Autofluorescence+Images+Shows+Short-Term+Progression+in+Stargardt+Disease&rft.au=Caruso%2C+R%3BZein%2C+W%3BCunningham%2C+D%3BRasband%2C+W&rft.aulast=Caruso&rft.aufirst=R&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Subpopulation of Th17 Cells Produce High Levels of IL-17, but Fail to Adoptively Transfer Ocular Inflammation T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40239976; 5210764 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Lovaas, J AU - Shi, G AU - Tan, C AU - Vistica, B AU - Wawrousek, E AU - Gery, I Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Subpopulations KW - Interleukin 17 KW - Inflammation KW - Helper cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40239976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=A+Subpopulation+of+Th17+Cells+Produce+High+Levels+of+IL-17%2C+but+Fail+to+Adoptively+Transfer+Ocular+Inflammation&rft.au=Lovaas%2C+J%3BShi%2C+G%3BTan%2C+C%3BVistica%2C+B%3BWawrousek%2C+E%3BGery%2C+I&rft.aulast=Lovaas&rft.aufirst=J&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IFNg Regulates Fluid Transport Across Human RPE: Role of CFTR T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40239826; 5209982 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Li, R. AU - Maminishkis, A AU - Banzon, T AU - Jalickee, S AU - Chen, S AU - Wan, Q AU - Miller, S Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40239826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=IFNg+Regulates+Fluid+Transport+Across+Human+RPE%3A+Role+of+CFTR&rft.au=Li%2C+R.%3BMaminishkis%2C+A%3BBanzon%2C+T%3BJalickee%2C+S%3BChen%2C+S%3BWan%2C+Q%3BMiller%2C+S&rft.aulast=Li&rft.aufirst=R.&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dicer and microRNAs Are Essential for Development of Lens and Cornea in Mice T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40239197; 5212546 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Li, Y. AU - Piatigorsky, J Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Mice KW - MiRNA KW - Cornea KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40239197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Dicer+and+microRNAs+Are+Essential+for+Development+of+Lens+and+Cornea+in+Mice&rft.au=Li%2C+Y.%3BPiatigorsky%2C+J&rft.aulast=Li&rft.aufirst=Y.&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Single Nucleotide Polymorphism in 5-UTR of ERCC6 Confers Protection Against Age-Related Macular Degeneration T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40238718; 5209683 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Tuo, J AU - Cho, Y AU - Chew, E AU - Chan, C.-C. Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Macular degeneration KW - Single-nucleotide polymorphism KW - Age KW - Nucleotides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40238718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=A+Single+Nucleotide+Polymorphism+in+5-UTR+of+ERCC6+Confers+Protection+Against+Age-Related+Macular+Degeneration&rft.au=Tuo%2C+J%3BCho%2C+Y%3BChew%2C+E%3BChan%2C+C.-C.&rft.aulast=Tuo&rft.aufirst=J&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Potentiation of Visible Light- Induced Photodamage in Cultured RPE Cells by Treatment With AY9944, A 7-Dehydrocholesterol Reductase Inhibitor T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40236825; 5209971 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Lee, J AU - Sanchez, J AU - Riddick, R AU - Huang, J.-D. AU - Fliesler, S AU - Rodriguez, I Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - 7-Dehydrocholesterol reductase KW - Potentiation KW - Inhibitors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40236825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Potentiation+of+Visible+Light-+Induced+Photodamage+in+Cultured+RPE+Cells+by+Treatment+With+AY9944%2C+A+7-Dehydrocholesterol+Reductase+Inhibitor&rft.au=Lee%2C+J%3BSanchez%2C+J%3BRiddick%2C+R%3BHuang%2C+J.-D.%3BFliesler%2C+S%3BRodriguez%2C+I&rft.aulast=Lee&rft.aufirst=J&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Pigment Epithelial Derived Factor on Murine Macrophages T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40236440; 5212479 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Faia, L AU - Li, Z. AU - Becerra, P AU - Amaral, J AU - Liu, B AU - Nussenblatt, R Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Pigments KW - Macrophages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40236440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=The+Effects+of+Pigment+Epithelial+Derived+Factor+on+Murine+Macrophages&rft.au=Faia%2C+L%3BLi%2C+Z.%3BBecerra%2C+P%3BAmaral%2C+J%3BLiu%2C+B%3BNussenblatt%2C+R&rft.aulast=Faia&rft.aufirst=L&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 7-Ketocholesterol Induces VEGF and Other Cytokines via Multiple Inflammatory Pathways T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40236246; 5209974 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Larrayoz, I AU - Pascual, I AU - Lee, J AU - Rodriguez, I Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Cytokines KW - Inflammation KW - Vascular endothelial growth factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40236246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=7-Ketocholesterol+Induces+VEGF+and+Other+Cytokines+via+Multiple+Inflammatory+Pathways&rft.au=Larrayoz%2C+I%3BPascual%2C+I%3BLee%2C+J%3BRodriguez%2C+I&rft.aulast=Larrayoz&rft.aufirst=I&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-27 Secreted by Retinal Microglia Induces IL-10 Expression in Retinal Cells. T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40235522; 5210767 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Amadi-Obi, A AU - Yu, C.-R. AU - Lee, Y AU - Mahdi, R AU - Egwuagu, C Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Retina KW - Interleukin 10 KW - Microglia KW - Interleukin 27 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40235522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=IL-27+Secreted+by+Retinal+Microglia+Induces+IL-10+Expression+in+Retinal+Cells.&rft.au=Amadi-Obi%2C+A%3BYu%2C+C.-R.%3BLee%2C+Y%3BMahdi%2C+R%3BEgwuagu%2C+C&rft.aulast=Amadi-Obi&rft.aufirst=A&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biochemical and Functional Studies of ARMS2, A Mitochondrial Protein Strongly Associated With Susceptibility to Age- Related Macular Degeneration T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40234344; 5210462 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Kanda, A AU - Estrada-Cuzcano, A AU - Hajkova, D AU - Miyagi, M AU - Swaroop, A Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Macular degeneration KW - Biochemistry KW - Mitochondria KW - Age KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40234344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Biochemical+and+Functional+Studies+of+ARMS2%2C+A+Mitochondrial+Protein+Strongly+Associated+With+Susceptibility+to+Age-+Related+Macular+Degeneration&rft.au=Kanda%2C+A%3BEstrada-Cuzcano%2C+A%3BHajkova%2C+D%3BMiyagi%2C+M%3BSwaroop%2C+A&rft.aulast=Kanda&rft.aufirst=A&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic heterogeneity, founder effects, population stratification, substructure and other things to consider in the design of genetic studies T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40233095; 5211172 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Bailey-Wilson, J Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Stratification KW - Founder effect KW - Population genetics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40233095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Genetic+heterogeneity%2C+founder+effects%2C+population+stratification%2C+substructure+and+other+things+to+consider+in+the+design+of+genetic+studies&rft.au=Bailey-Wilson%2C+J&rft.aulast=Bailey-Wilson&rft.aufirst=J&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genotype-Phenotype Correlation in Ocular von Hippel-Lindau Disease: The Effect of Missense Mutation Position on Ocular Phenotype T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40233039; 5212258 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Mettu, P AU - Agron, E AU - Chew, E Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Missense mutation KW - Von Hippel-Lindau disease KW - Phenotypes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40233039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Genotype-Phenotype+Correlation+in+Ocular+von+Hippel-Lindau+Disease%3A+The+Effect+of+Missense+Mutation+Position+on+Ocular+Phenotype&rft.au=Mettu%2C+P%3BAgron%2C+E%3BChew%2C+E&rft.aulast=Mettu&rft.aufirst=P&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monosaccharide Composition and Asparagine-Linked Oligosaccharide Profile of Interphotoreceptor Retinoid-Binding Protein T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40231656; 5211125 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Duncan, T AU - Kutty, R AU - Samuel, W AU - Redmond, T Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Monosaccharides KW - Oligosaccharides KW - Interphotoreceptor retinoid-binding protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40231656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Monosaccharide+Composition+and+Asparagine-Linked+Oligosaccharide+Profile+of+Interphotoreceptor+Retinoid-Binding+Protein&rft.au=Duncan%2C+T%3BKutty%2C+R%3BSamuel%2C+W%3BRedmond%2C+T&rft.aulast=Duncan&rft.aufirst=T&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Fetal and Adult RPE Gene Expression Signature: Function and Disease Association T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40231111; 5211045 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Strunnikova, N AU - Barb, J AU - Zhi, C AU - Maminishkis, A AU - Munson, P AU - Miller, S Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Gene expression KW - Fetuses KW - Public health KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40231111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Human+Fetal+and+Adult+RPE+Gene+Expression+Signature%3A+Function+and+Disease+Association&rft.au=Strunnikova%2C+N%3BBarb%2C+J%3BZhi%2C+C%3BMaminishkis%2C+A%3BMunson%2C+P%3BMiller%2C+S&rft.aulast=Strunnikova&rft.aufirst=N&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intravitreal Administration of an AAV8 Retinoschisin Vector to the RS1-KO Mouse Results in Cell Type-Specific Gene Expression and Rescue of the Disease Phenotype T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40230990; 5209869 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Park, T AU - Wu, Z. AU - Kjellstrom, S AU - Zeng, Y AU - Bush, R AU - Sieving, P AU - Colosi, P Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Gene expression KW - Expression vectors KW - Disease transmission KW - Hosts KW - Phenotypes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40230990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Intravitreal+Administration+of+an+AAV8+Retinoschisin+Vector+to+the+RS1-KO+Mouse+Results+in+Cell+Type-Specific+Gene+Expression+and+Rescue+of+the+Disease+Phenotype&rft.au=Park%2C+T%3BWu%2C+Z.%3BKjellstrom%2C+S%3BZeng%2C+Y%3BBush%2C+R%3BSieving%2C+P%3BColosi%2C+P&rft.aulast=Park&rft.aufirst=T&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Is Essential for Recruitment of Active Src to Focal Adhesions T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40229682; 5210712 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Pan, Q AU - Parthasarathy, A AU - Zelenka, P Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Adhesion KW - Recruitment KW - Src protein KW - Cyclin-dependent kinase 5 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40229682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Cdk5+Is+Essential+for+Recruitment+of+Active+Src+to+Focal+Adhesions&rft.au=Pan%2C+Q%3BParthasarathy%2C+A%3BZelenka%2C+P&rft.aulast=Pan&rft.aufirst=Q&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combination Daclizumab/ Sirolimus Therapy for the Induction of Immune Tolerance in Non-Infectious Intermediate and Posterior Uveitis T2 - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AN - 40226906; 5210153 JF - 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2009) AU - Wroblewski, K AU - Sen, H AU - Faia, L AU - Yeh, S AU - Nussenblatt, R AU - Ragheb, J Y1 - 2009/05/03/ PY - 2009 DA - 2009 May 03 KW - Uveitis KW - Sirolimus KW - Immunological tolerance KW - Therapy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40226906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.atitle=Combination+Daclizumab%2F+Sirolimus+Therapy+for+the+Induction+of+Immune+Tolerance+in+Non-Infectious+Intermediate+and+Posterior+Uveitis&rft.au=Wroblewski%2C+K%3BSen%2C+H%3BFaia%2C+L%3BYeh%2C+S%3BNussenblatt%2C+R%3BRagheb%2C+J&rft.aulast=Wroblewski&rft.aufirst=K&rft.date=2009-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.arvo.org/EWEB/dynamicpage.aspx?site=am2009&WebCode=progbook LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Anatomical Brain Magnetic Resonance Imaging of Typically Developing Children and Adolescents AN - 919969574; 201201783 AB - Many psychiatric disorders, including some with adult onset such as schizophrenia, are increasingly being conceptualized as stemming from anomalies of neurodevelopment. To explore neurodevelopmental hypotheses of illness, it is useful to have well-characterized data regarding typical maturation to serve as a "yardstick" from which to assess possible deviations. Studies of typical development, and the influences on that development, may also unveil the timing and mechanisms of brain maturation guiding the way for novel interventions. In this overview, we will touch on methodological issues relevant to magnetic resonance imaging (MRI) studies of brain anatomy, summarize MRI findings of neuroanatomic changes during childhood and adolescence, and discuss possible influences on brain development trajectories. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Giedd, Jay N AU - Lalonde, Francois M AU - Celano, Mark J AU - White, Samantha L AU - Wallace, Gregory L AU - Lee, Nancy R AU - Lenroot, Rhoshel K AD - Child Psychiatry Branch, National Institute of Mental Health, Building 10, Room 4C110, 10 Center Drive, Bethesda, MD 20854 Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 465 EP - 470 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 48 IS - 5 SN - 0890-8567, 0890-8567 KW - Maturation KW - Magnetic resonance imaging KW - Brain KW - Deviation KW - Children KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919969574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Anatomical+Brain+Magnetic+Resonance+Imaging+of+Typically+Developing+Children+and+Adolescents&rft.au=Giedd%2C+Jay+N%3BLalonde%2C+Francois+M%3BCelano%2C+Mark+J%3BWhite%2C+Samantha+L%3BWallace%2C+Gregory+L%3BLee%2C+Nancy+R%3BLenroot%2C+Rhoshel+K&rft.aulast=Giedd&rft.aufirst=Jay&rft.date=2009-05-01&rft.volume=48&rft.issue=5&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e31819f2715 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Brain; Adolescents; Maturation; Deviation; Children DO - http://dx.doi.org/10.1097/CHI.0b013e31819f2715 ER - TY - JOUR T1 - Nanoparticle therapeutics: a personal perspective AN - 869595338; 14821104 AB - Nanotechnology offers many potential benefits to cancer research through passive and active targeting, increased solubility/bioavailablility, and novel therapies. However, preclinical characterization of nanoparticles is complicated by the variety of materials, their unique surface properties, reactivity, and the task of tracking the individual components of multicomponent, multifunctional nanoparticle therapeutics in in vivo studies. There are also regulatory considerations and scale-up challenges that must be addressed. Despite these hurdles, cancer research has seen appreciable improvements in efficacy and quite a decrease in the toxicity of chemotherapeutics because of 'nanotech' formulations, and several engineered nanoparticle clinical trials are well underway. This article reviews some of the challenges and benefits of nanomedicine for cancer therapeutics and diagnostics. JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - McNeil, Scott E AD - Nanotechnology Characterization Lab, Imaging and Nanotechnology Group, SAIC-Frederick Inc./National Cancer Institute at Frederick, Frederick, MD, USA., ncl@mail.nih.gov Y1 - 2009/05/01/ PY - 2009 DA - 2009 May 01 SP - 264 EP - 271 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 1 IS - 3 SN - 1939-0041, 1939-0041 KW - Biotechnology and Bioengineering Abstracts KW - Surface properties KW - Solubility KW - Toxicity KW - nanoparticles KW - Clinical trials KW - Cancer KW - nanotechnology KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869595338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Nanoparticle+therapeutics%3A+a+personal+perspective&rft.au=McNeil%2C+Scott+E&rft.aulast=McNeil&rft.aufirst=Scott&rft.date=2009-05-01&rft.volume=1&rft.issue=3&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Surface properties; Solubility; Toxicity; Clinical trials; nanoparticles; Cancer; nanotechnology DO - http://dx.doi.org/10.1002/wnan.6 ER - TY - JOUR T1 - Simultaneous quantification of buprenorphine, norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide in human placenta by liquid chromatography mass spectrometry AN - 753651822; 13323807 AB - A LCMS method was developed and validated for the determination of buprenorphine (BUP), norbuprenorphine (NBUP), buprenorphine glucuronide (BUP-Gluc), and norbuprenorphine glucuronide (NBUP-Gluc) in placenta. Quantification was achieved by selected ion monitoring of m/z 468.4 (BUP), 414.3 (NBUP), 644.4 (BUP-Gluc), and 590 (NBUP-Gluc). BUP and NBUP were identified monitoring MS fragments m/z 396, 414 and 426 for BUP, and 340, 364 and 382 for NBUP, and glucuronide conjugates monitoring MS fragments m/z 396 and 414 for BUP-Gluc, and 340 and 382 for NBUP-Gluc. Linearity was 1--50 ng/g. Intra-day, inter-day and total assay imprecision (% RSD) were <13.4%, and analytical recoveries were 96.2--113.1%. Extraction efficiencies ranged from 40.7--68%, process efficiencies 38.8--70.5%, and matrix effect 1.3--15.4%. Limits of detection were 0.8 ng/g for all compounds. An authentic placenta from an opioid-dependent pregnant woman receiving BUP pharmacotherapy was analyzed. BUP was not detected but metabolite concentrations were NBUP-Gluc 46.6, NBUP 15.7 and BUP-Gluc 3.2 ng/g. JF - Analytical and Bioanalytical Chemistry AU - Concheiro-Guisan, Marta AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center (BRC), 251 Bayview Boulevard, Suite 200, Room 05A721, Baltimore, MD 21224, USA, mhuestis@intra.nida.nih.gov PY - 2009 SP - 513 EP - 522 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 394 IS - 2 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Mass Spectrometry KW - Assay KW - Liquid Chromatography KW - Metabolites KW - Monitoring KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753651822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Simultaneous+quantification+of+buprenorphine%2C+norbuprenorphine%2C+buprenorphine+glucuronide%2C+and+norbuprenorphine+glucuronide+in+human+placenta+by+liquid+chromatography+mass+spectrometry&rft.au=Concheiro-Guisan%2C+Marta%3BShakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Concheiro-Guisan&rft.aufirst=Marta&rft.date=2009-05-01&rft.volume=394&rft.issue=2&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-009-2706-z L2 - http://www.springerlink.com/content/x15t973g1602mr00/?p=54e9bda5905b4bd3b31a2367b35d6921&pi=14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Mass Spectrometry; Assay; Liquid Chromatography; Metabolites; Monitoring DO - http://dx.doi.org/10.1007/s00216-009-2706-z ER - TY - JOUR T1 - Miniaturized 96-well ELISA chips for staphylococcal enterotoxin B detection using portable colorimetric detector AN - 753651166; 13323805 AB - A previously developed fluorescence sensing platform, combining spatial illumination using electroluminescence (EL) semiconductor strips with charge coupled device (CCD)-based detection (EL-CCD), was adapted to a new 96-well chip for colorimetric immunological assays, enhancing the capabilities of the EL-CCD platform. The modified system was demonstrated using a colorimetric-based enzyme linked immunosorbent assay (ELISA) for detection of staphylococcal enterotoxin B (SEB). Limits of detection (LODs) of 3.9 ng/mL (c2.4 ng/mL) SEB were determined with the ELISA chip measured using the EL-CCD platform, following a standard 4-h ELISA protocol. The LODs were comparable to those obtained using standard 96-well ELISA plates measured using a standard laboratory 96-well plate reader. The miniature 96-well ELISA chip however required as little as 5-kL samples, representing a tenfold reduction in sample volume compared to a standard 96-well ELISA plates. The ELISA chip also demonstrated detection of SEB spiked into various food matrices (milk, mushrooms, and mayonnaise) using limited-to-no sample preparation, with LODs ranging from 3.9 to 18.5 ng/mL depending on the matrix. The EL-CCD platform is versatile, capable of multi-mode detection (e.g., fluorescent and colorimetric along with solution and solid phase assays), and could readily be applied to other field portable or point-of-care applications. JF - Analytical and Bioanalytical Chemistry AU - Sapsford, Kim E AU - Francis, Jesse AU - Sun, Steven AU - Kostov, Yordan AU - Rasooly, Avraham AD - Division of Biology, Office of Science and Engineering Laboratories, CDRH, FDA, Silver Spring, MD 20993, USA, rasoolya@mail.nih.gov PY - 2009 SP - 499 EP - 505 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 394 IS - 2 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts; Microbiology Abstracts B: Bacteriology KW - Food KW - Colorimetry KW - Sample Preparation KW - Assay KW - Enzyme-linked immunosorbent assay KW - Fluorescence KW - Milk KW - Laboratories KW - Enzymes KW - Solids KW - Staphylococcal enterotoxin B KW - Basidiocarps KW - Foods KW - Illumination KW - Standards KW - Mayonnaise KW - Solid phase methods KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - J 02420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753651166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Miniaturized+96-well+ELISA+chips+for+staphylococcal+enterotoxin+B+detection+using+portable+colorimetric+detector&rft.au=Sapsford%2C+Kim+E%3BFrancis%2C+Jesse%3BSun%2C+Steven%3BKostov%2C+Yordan%3BRasooly%2C+Avraham&rft.aulast=Sapsford&rft.aufirst=Kim&rft.date=2009-05-01&rft.volume=394&rft.issue=2&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-009-2730-z L2 - http://www.springerlink.com/content/x73q4g7256171713/?p=54e9bda5905b4bd3b31a2367b35d6921&pi=12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Milk; Fluorescence; Illumination; Food; Colorimetry; Mayonnaise; Solid phase methods; Staphylococcal enterotoxin B; Basidiocarps; Sample Preparation; Foods; Laboratories; Assay; Enzymes; Solids; Standards DO - http://dx.doi.org/10.1007/s00216-009-2730-z ER - TY - JOUR T1 - The complex dance of the molecular chaperone Hsp90 AN - 746228695; 12976733 AB - Hsp90 chaperone function requires traversal of a nucleotide-dependent conformational cycle, but the slow and variable rate of Hsp90-mediated ATP hydrolysis is difficult to envision as a determinant of conformational change. A recent study solves this dilemma by showing that Hsp90 samples multiple conformational states in the absence of nucleotides, which serve to influence, but not direct, the cycle. The conformational program of Hsp90 is conserved from bacteria to humans, although the population dynamics are species specific. JF - Trends in Biochemical Sciences AU - Neckers, Len AU - Mollapour, Mehdi AU - Tsutsumi, Shinji AD - Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA, len@helix.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 223 EP - 226 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 34 IS - 5 SN - 0968-0004, 0968-0004 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Hsp90 protein KW - Reviews KW - ATP KW - Chaperones KW - Population dynamics KW - Hydrolysis KW - Nucleotides KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746228695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Biochemical+Sciences&rft.atitle=The+complex+dance+of+the+molecular+chaperone+Hsp90&rft.au=Neckers%2C+Len%3BMollapour%2C+Mehdi%3BTsutsumi%2C+Shinji&rft.aulast=Neckers&rft.aufirst=Len&rft.date=2009-05-01&rft.volume=34&rft.issue=5&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Trends+in+Biochemical+Sciences&rft.issn=09680004&rft_id=info:doi/10.1016%2Fj.tibs.2009.01.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Hsp90 protein; Reviews; ATP; Chaperones; Population dynamics; Hydrolysis; Nucleotides DO - http://dx.doi.org/10.1016/j.tibs.2009.01.006 ER - TY - JOUR T1 - How well does structural equation modeling reveal abnormal brain anatomical connections? An fMRI simulation study AN - 746082223; 12978465 AB - Many brain disorders result from alterations in the strength of anatomical connectivity between different brain regions. This study investigates whether such alterations can be revealed by examining differences in interregional effective connectivity between patient and normal subjects. We applied one prominent effective connectivity method - Structural Equation Modeling (SEM) - to simulated functional MRI (fMRI) timeseries from a neurobiologically realistic network model in which the anatomical connectivity is known and can be manipulated. These timeseries were simulated for two task conditions, a delayed match-to-sample (DMS) task and passive-viewing, and for "normal subjects" and "patients" who had one weakened anatomical connection in the neural network model. SEM results were compared between task conditions as well as between groups. A significantly reduced effective connectivity corresponding to the weakened anatomical connection during the DMS task was found. We also obtained a significantly reduced set of effective connections in the patient networks for anatomical connections "downstream" from the weakened linkage. However, some "upstream" effective connections were significantly larger in the patient group relative to normals. Finally, we found that of the SEM model measures we examined, the total error variance was the best at distinguishing a patient network from a normal network. These results suggest that caution is necessary in applying effective connectivity methods to fMRI data obtained from non-normal populations, and emphasize that functional interactions among network elements can appear as abnormal even if only part of a network is damaged. JF - NeuroImage AU - Kim, Jieun AU - Horwitz, Barry AD - Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, Bldg. 10, Rm. 8S235, MSC 1407, National Institutes of Health, Bethesda, MD 20892, USA, horwitzb@mail.nih.gov Y1 - 2009/05/01/ PY - 2009 DA - 2009 May 01 SP - 1190 EP - 1198 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 45 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Neuroimaging KW - Mathematical models KW - Data processing KW - Neural networks KW - Functional magnetic resonance imaging KW - N3 11002:Computational & theoretical neuroscience KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746082223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=How+well+does+structural+equation+modeling+reveal+abnormal+brain+anatomical+connections%3F+An+fMRI+simulation+study&rft.au=Kim%2C+Jieun%3BHorwitz%2C+Barry&rft.aulast=Kim&rft.aufirst=Jieun&rft.date=2009-05-01&rft.volume=45&rft.issue=4&rft.spage=1190&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.01.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Brain mapping; Neuroimaging; Data processing; Mathematical models; Neural networks; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2009.01.006 ER - TY - JOUR T1 - Hyperstimulation of striatal D2 receptors with sleep deprivation: Implications for cognitive impairment AN - 746079443; 12978469 AB - Sleep deprivation interferes with cognitive performance but the mechanisms are poorly understood. We recently reported that one night of sleep deprivation increased dopamine in striatum (measured with [ super(11)C]raclopride, a PET radiotracer that competes with endogenous dopamine for binding to D2 receptors) and that these increases were associated with impaired performance in a visual attention task. To better understand this association here we evaluate the relationship between changes in striatal dopamine (measured as changes in D2 receptor availability using PET and [ super(11)C]raclopride) and changes in brain activation to a visual attention task (measured with BOLD and fMRI) when performed during sleep deprivation versus during rested wakefulness. We find that sleep induced changes in striatal dopamine were associated with changes in cortical brain regions modulated by dopamine (attenuated deactivation of anterior cingulate gyrus and insula) but also in regions that are not recognized targets of dopaminergic modulation (attenuated activation of inferior occipital cortex and cerebellum). Moreover, the increases in striatal dopamine as well as its associated regional activation and deactivation patterns correlated negatively with performance accuracy. These findings therefore suggest that hyperstimulation of D2 receptors in striatum may contribute to the impairment in visual attention during sleep deprivation. Thus, while dopamine increases in prefrontal regions (including stimulation of D1 receptors) may facilitate attention our findings suggest that hyperstimulation of D2 receptors in striatum may impair it. Alternatively, these associations may reflect a compensatory striatal dopamine response (to maintain arousal) that is superimposed on a larger response to sleep deprivation. JF - NeuroImage AU - Volkow, Nora D AU - Tomasi, Dardo AU - Wang, Gene-Jack AU - Telang, Frank AU - Fowler, Joanna S AU - Wang, Ruiliang L AU - Logan, Jean AU - Wong, Christopher AU - Jayne, Millard AU - Swanson, James M AD - National Institute on Drug Abuse, Bethesda, MD 20892, USA, nvolkow@nida.nih.govvolkow@bnl.gov Y1 - 2009/05/01/ PY - 2009 DA - 2009 May 01 SP - 1232 EP - 1240 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 45 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Dopamine D2 receptors KW - Raclopride KW - Visual attention KW - PET KW - fMRI KW - Default network KW - Thalamus KW - Brain mapping KW - Neuroimaging KW - Arousal KW - Functional magnetic resonance imaging KW - Cortex (occipital) KW - Cerebellum KW - Dopamine D1 receptors KW - Sleep and wakefulness KW - Cortex (cingulate) KW - Attention task KW - Sleep deprivation KW - Cognitive ability KW - Visual perception KW - Cortex (visual) KW - Neostriatum KW - Positron emission tomography KW - Deactivation KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Hyperstimulation+of+striatal+D2+receptors+with+sleep+deprivation%3A+Implications+for+cognitive+impairment&rft.au=Volkow%2C+Nora+D%3BTomasi%2C+Dardo%3BWang%2C+Gene-Jack%3BTelang%2C+Frank%3BFowler%2C+Joanna+S%3BWang%2C+Ruiliang+L%3BLogan%2C+Jean%3BWong%2C+Christopher%3BJayne%2C+Millard%3BSwanson%2C+James+M&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2009-05-01&rft.volume=45&rft.issue=4&rft.spage=1232&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Brain mapping; Neuroimaging; Arousal; Functional magnetic resonance imaging; Cortex (occipital); Dopamine D1 receptors; Cerebellum; Sleep and wakefulness; Cortex (cingulate); Attention task; Sleep deprivation; Cortex (visual); Visual perception; Cognitive ability; Neostriatum; Positron emission tomography; Deactivation DO - http://dx.doi.org/10.1016/j.neuroimage.2009.01.003 ER - TY - JOUR T1 - Serotonergic drugs and valvular heart disease AN - 744694361; 13097672 AB - Background: The serotonin (5-HT) releasers ( plus or minus )-fenfluramine and (+)-fenfluramine were withdrawn from clinical use owing to increased risk of valvular heart disease. One prevailing hypothesis (i.e., the '5-HT hypothesis') suggests that fenfluramine-induced increases in plasma 5-HT underlie the disease. Objective: Here, we critically evaluate the possible mechanisms responsible for fenfluramine-associated valve disease. Methods: Findings from in vitro and in vivo experiments performed in our laboratory are reviewed. The data are integrated with existing literature to address the validity of the 5-HT hypothesis and suggest alternative explanations. Conclusions: The overwhelming majority of evidence refutes the 5-HT hypothesis. A more likely cause of fenfluramine-induced valvulopathy is activation of 5-HT sub(2B) receptors on heart valves by the metabolite norfenfluramine. Future serotonergic medications should be designed to lack 5-HT sub(2B) agonist activity. JF - Expert Opinion on Drug Safety AU - Rothman, R B AU - Baumann, M H AD - Clinical Psychopharmacology Section, IRP/NIDA/NIH, 333 Cassell Drive, Suite 4500 Baltimore, Maryland 21224, USA, rrothman@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 317 EP - 329 VL - 8 IS - 3 SN - 1474-0338, 1474-0338 KW - Health & Safety Science Abstracts KW - Laboratory testing KW - Reviews KW - Metabolites KW - Drugs KW - heart diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744694361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Measuring+Adverse+Events+and+Levels+of+Harm+in+Pediatric+Inpatients+With+the+Global+Trigger+Tool&rft.au=Kirkendall%2C+Eric+S%2C+MD%3BKloppenborg%2C+Elizabeth%2C+MSN%2C+BSN%3BPapp%2C+James%2C+MSW%3BWhite%2C+Denise%2C+PhD%3BFrese%2C+Carol%2C+BSN%2C+RN%3BHacker%2C+Deborah%2C+ASN%2C+RN%3BSchoettker%2C+Pamela+J%2C+MS%3BMuething%2C+Stephen%2C+MD%3BKotagal%2C+Uma%2C+MBBS%2C+MSc&rft.aulast=Kirkendall&rft.aufirst=Eric&rft.date=2012-11-01&rft.volume=130&rft.issue=5&rft.spage=e1206&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Laboratory testing; Reviews; Metabolites; Drugs; heart diseases DO - http://dx.doi.org/10.1517/14740330902931524 ER - TY - JOUR T1 - Phonological processing in adults with deficits in musical pitch recognition. AN - 742787566; pmid-19233383 AB - We identified individuals with deficits in musical pitch recognition by screening a large random population using the Distorted Tunes Test (DTT), and enrolled individuals who had DTT scores in the lowest 10th percentile, classified as tune deaf. We examined phonological processing abilities in 35 tune deaf and 34 normal control individuals. Eight different tests of phonological processing, including auditory word discrimination, syllable segmentation, and the Comprehensive Test of Phonological Processing (CTOPP) were administered to both groups. The tune deaf group displayed lower phonological and phonemic awareness abilities on all measures. Our results indicate that poor performance on the DTT is associated with deficits in processing speech sounds. These findings support the hypothesis that processing of speech sounds and musical sounds share common elements, and that tune deafness may be viewed as a syndromic disorder, frequently accompanied by deficits in a number of aspects of sound processing not specific to music. LEARNING OUTCOMES: The reader will (1) understand the broad range of deficits in phonological perception and processing that accompany deficits in musical pitch recognition, and (2) recognize the possible utility of musical evaluation measures and music-based therapies in the treatment of phonological and other speech disorders. JF - Journal of communication disorders AU - Jones, Jennifer L AU - Lucker, Jay AU - Zalewski, Christopher AU - Brewer, Carmen AU - Drayna, Dennis AD - National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 226 EP - 234 VL - 42 IS - 3 SN - 0021-9924, 0021-9924 KW - Index Medicus KW - National Library of Medicine KW - Language Tests KW - Young Adult KW - Discrimination (Psychology) KW - Humans KW - Adult KW - Middle Aged KW - Acoustic Stimulation KW - Neuropsychological Tests KW - Adolescent KW - Speech KW - Male KW - Female KW - Speech Perception KW - Phonetics KW - Pitch Perception KW - Music KW - Auditory Perceptual Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742787566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+communication+disorders&rft.atitle=Phonological+processing+in+adults+with+deficits+in+musical+pitch+recognition.&rft.au=Jones%2C+Jennifer+L%3BLucker%2C+Jay%3BZalewski%2C+Christopher%3BBrewer%2C+Carmen%3BDrayna%2C+Dennis&rft.aulast=Jones&rft.aufirst=Jennifer&rft.date=2009-05-01&rft.volume=42&rft.issue=3&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Journal+of+communication+disorders&rft.issn=00219924&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-05-19 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Dietary meat intake in relation to colorectal adenoma in asymptomatic women. AN - 742781870; pmid-19367270 AB - OBJECTIVES: No previous study has concurrently assessed the associations between meat intake, meat-cooking methods and doneness levels, meat mutagens (heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons), heme iron, and nitrite from meat and colorectal adenoma in asymptomatic women undergoing colonoscopy. METHODS: Of the 807 eligible women in a cross-sectional multicenter colonoscopy screening study, 158 prevalent colorectal adenoma cases and 649 controls satisfactorily completed the validated food frequency and meat questionnaires. Using an established meat mutagen database and new heme iron and nitrite databases, we comprehensively investigated the components of meat that may be involved in carcinogenesis. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) within quartiles of meat-related variables. RESULTS: Red meat was associated positively with colorectal adenoma (OR fourth vs. first quartile = 2.02; 95% CI = 1.06-3.83; P trend = 0.38). Intake of pan-fried meat (OR = 1.72; 95% CI = 0.96-3.07; P trend = 0.01) and the HCA: 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) (OR = 1.90; 95% CI = 1.05-3.42; P trend = 0.07) were also associated with an increased risk of colorectal adenoma. The new databases yielded lower estimates of heme iron and nitrite than previous assessment methods, although the two methods were highly correlated for both exposures. Although not statistically significant, there were positive associations between iron and heme iron from meat and colorectal adenoma. CONCLUSIONS: In asymptomatic women undergoing colonoscopy, colorectal adenomas were associated with high intake of red meat, pan-fried meat, and the HCA MeIQx. Other meat-related exposures require further investigation. JF - The American journal of gastroenterology AU - Ferrucci, Leah M AU - Sinha, Rashmi AU - Graubard, Barry I AU - Mayne, Susan T AU - Ma, Xiaomei AU - Schatzkin, Arthur AU - Schoenfeld, Philip S AU - Cash, Brooks D AU - Flood, Andrew AU - Cross, Amanda J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. ferruccil@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1231 EP - 1240 VL - 104 IS - 5 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Colorectal Neoplasms -- diagnosis KW - Reference Values KW - Odds Ratio KW - Cookery KW - Humans KW - Aged KW - Mass Screening -- methods KW - Colonoscopy -- methods KW - Diet -- adverse effects KW - Risk Assessment KW - Multivariate Analysis KW - Cross-Sectional Studies KW - Logistic Models KW - Adult KW - Adenoma -- epidemiology KW - Colorectal Neoplasms -- etiology KW - Adenoma -- etiology KW - Confidence Intervals KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Colorectal Neoplasms -- epidemiology KW - Adenoma -- diagnosis KW - Female KW - Meat Products -- adverse effects KW - Heterocyclic Compounds -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742781870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Dietary+meat+intake+in+relation+to+colorectal+adenoma+in+asymptomatic+women.&rft.au=Ferrucci%2C+Leah+M%3BSinha%2C+Rashmi%3BGraubard%2C+Barry+I%3BMayne%2C+Susan+T%3BMa%2C+Xiaomei%3BSchatzkin%2C+Arthur%3BSchoenfeld%2C+Philip+S%3BCash%2C+Brooks+D%3BFlood%2C+Andrew%3BCross%2C+Amanda+J&rft.aulast=Ferrucci&rft.aufirst=Leah&rft.date=2009-05-01&rft.volume=104&rft.issue=5&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-07-08 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Age of drinking onset and injuries, motor vehicle crashes, and physical fights after drinking and when not drinking. AN - 733094170; 19298330 AB - Earlier age of drinking onset has been associated with greater odds of involvement in motor vehicle crashes, unintentional injuries, and physical fights after drinking. This study explores whether early drinkers take more risks even when sober by comparing potential associations between age of drinking onset and these outcomes after drinking relative to when respondents have not been drinking. From a national sample, 4,021 ever-drinkers ages 18 to 39 were asked age of drinking onset, not counting tastes or sips. They were also asked if they were ever in motor vehicle crashes, unintentionally injured, or in physical fights after drinking and when not drinking. GEE logistic regression models for repeated measures dichotomous outcomes compared whether odds ratios between age of onset and these adverse outcomes significantly differed when they occurred after drinking versus when not drinking, controlling for respondents' demographic characteristics, cigarette and marijuana use, family history of alcoholism, ever experiencing alcohol dependence, and frequency of binge drinking. Compared with persons who started drinking at age 21+, those who started at ages <14, 14 to 15, 16 to 17, and 18 to 20 had, after drinking, respectively greater odds: 6.3 (2.6, 15.3), 5.2 (2.2, 12.3), 3.3 (1.5, 7.3), and 2.2 (0.9, 5.1) of having been in a motor vehicle crash; 6.0 (3.4, 10.5), 4.9 (3.0, 8.6), 3.7 (2.4, 5.6), and 1.9 (1.2, 2.9) of ever being in a fight; and 4.6 (2.4, 8.7), 4.7 (2.6, 8.6), 3.2 (1.9, 5.6), and 2.3 (1.3, 4.0) of ever being accidentally injured. The odds of experiencing motor vehicle accidents or injuries when not drinking were not significantly elevated among early onset drinkers. The odds of earlier onset drinkers being in fights were also significantly greater when respondents had been drinking than not drinking. Starting to drink at an earlier age is associated with greater odds of experiencing motor vehicle crash involvement, unintentional injuries, and physical fights when respondents were drinking, but less so when respondents had not been drinking. These findings reinforce the need for programs and policies to delay drinking onset. JF - Alcoholism, clinical and experimental research AU - Hingson, Ralph W AU - Edwards, Erika M AU - Heeren, Timothy AU - Rosenbloom, David AD - Division of Epidemiology and Prevention Research, National Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Bethesda, MD 20892, USA. rhingson@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 783 EP - 790 VL - 33 IS - 5 KW - Index Medicus KW - Young Adult KW - Alcoholic Intoxication -- psychology KW - Age Factors KW - Alcoholic Intoxication -- epidemiology KW - Alcoholism -- epidemiology KW - Humans KW - Adult KW - Interviews as Topic KW - Adolescent KW - Alcoholism -- psychology KW - Alcoholism -- complications KW - Male KW - Female KW - Accidental Falls KW - Aggression -- psychology KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- adverse effects KW - Accidents, Traffic -- psychology KW - Alcohol Drinking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733094170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Age+of+drinking+onset+and+injuries%2C+motor+vehicle+crashes%2C+and+physical+fights+after+drinking+and+when+not+drinking.&rft.au=Hingson%2C+Ralph+W%3BEdwards%2C+Erika+M%3BHeeren%2C+Timothy%3BRosenbloom%2C+David&rft.aulast=Hingson&rft.aufirst=Ralph&rft.date=2009-05-01&rft.volume=33&rft.issue=5&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=1530-0277&rft_id=info:doi/10.1111%2Fj.1530-0277.2009.00896.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-11 N1 - Date created - 2009-05-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Alcohol Clin Exp Res. 2008 Feb;32(2):222-9 [18162076] Alcohol Res Health. 2004-2005;28(3):107-8 [19093683] S Afr Med J. 2001 Feb;91(2):145-50 [11288397] Pediatrics. 2001 Oct;108(4):872-7 [11581438] Am J Prev Med. 2001 Nov;21(4 Suppl):66-88 [11691562] J Subst Abuse. 2001;13(4):493-504 [11775078] Accid Anal Prev. 2002 Jan;34(1):85-92 [11789578] J Stud Alcohol Suppl. 2002 Mar;(14):206-25 [12022726] Pediatrics. 2003 May;111(5 Pt 1):949-55 [12728070] Subst Use Misuse. 2003 Dec;38(14):1983-2016 [14677779] Drug Alcohol Depend. 2004 Jun 11;74(3):223-34 [15194200] J Stud Alcohol. 1991 Sep;52(5):478-91 [1943105] J Subst Abuse. 1997;9:103-10 [9494942] Alcohol Clin Exp Res. 1999 Jan;23(1):101-7 [10029209] Arch Pediatr Adolesc Med. 1999 Mar;153(3):286-91 [10086407] Addiction. 2004 Dec;99(12):1529-41 [15585044] Health Educ Behav. 2005 Apr;32(2):175-94 [15749965] Annu Rev Public Health. 2005;26:259-79 [15760289] Psychol Med. 2006 Jan;36(1):109-18 [16194286] Arch Pediatr Adolesc Med. 2006 Jul;160(7):739-46 [16818840] J Sch Health. 2006 Oct;76(8):423-9 [16978166] J Safety Res. 2006;37(5):443-51 [17123546] J Stud Alcohol Drugs. 2007 Mar;68(2):208-19 [17286339] J Interpers Violence. 2007 May;22(5):585-602 [17429024] J Adolesc Health. 2007 Aug;41(2):175-81 [17659222] Addict Behav. 2007 Nov;32(11):2439-68 [17604915] J Stud Alcohol Drugs. 2007 Nov;68(6):798-804 [17960297] Pediatrics. 2008 Feb;121(2):297-305 [18245421] Pediatrics. 2008 Aug;122(2):e298-304 [18676515] JAMA. 2000 Sep 27;284(12):1527-33 [11000646] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1530-0277.2009.00896.x ER - TY - JOUR T1 - The dimensionality of DSM-IV alcohol use disorders among adolescent and adult drinkers and symptom patterns by age, gender, and race/ethnicity. AN - 733093993; 19320629 AB - There is limited information on the validity of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) alcohol use disorders (AUD) symptom criteria among adolescents in the general population. The purpose of this study is to assess the DSM-IV AUD symptom criteria as reported by adolescent and adult drinkers in a single representative sample of the U.S. population aged 12 years and older. This design avoids potential confounding due to differences in survey methodology when comparing adolescents and adults from different surveys. A total of 133,231 current drinkers (had at least 1 drink in the past year) aged 12 years and older were drawn from respondents to the 2002 to 2005 National Surveys on Drug Use and Health. DSM-IV AUD criteria were assessed by questions related to specific symptoms occurring during the past 12 months. Factor analytic and item response theory models were applied to the 11 AUD symptom criteria to assess the probabilities of symptom item endorsements across different values of the underlying trait. A 1-factor model provided an adequate and parsimonious interpretation for the 11 AUD criteria for the total sample and for each of the gender-age groups. The MIMIC model exhibited significant indication for item bias among some criteria by gender, age, and race/ethnicity. Symptom criteria for "tolerance,""time spent," and "hazardous use" had lower item thresholds (i.e., lower severity) and low item discrimination, and they were well separated from the other symptoms, especially in the 2 younger age groups (12 to 17 and 18 to 25). "Larger amounts,""cut down,""withdrawal," and "legal problems" had higher item thresholds but generally lower item discrimination, and they tend to exhibit greater dispersion at higher AUD severity, particularly in the youngest age group (12 to 17). Findings from the present study do not provide support for the 2 separate DSM-IV diagnoses of alcohol abuse and dependence among either adolescents or adults. Variations in criteria severity for both abuse and dependence offer support for a dimensional approach to diagnosis which should be considered in the ongoing development of DSM-V. JF - Alcoholism, clinical and experimental research AU - Harford, Thomas C AU - Yi, Hsiao-ye AU - Faden, Vivian B AU - Chen, Chiung M AD - Alcohol Epidemiologic Data System, NIAAA/NIH, CSR Incorporated, 2107 Wilson Boulevard, Arlington, VA 22201, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 868 EP - 878 VL - 33 IS - 5 KW - Index Medicus KW - Young Adult KW - Age Factors KW - Sex Factors KW - Humans KW - Health Surveys KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Alcohol-Related Disorders -- classification KW - Continental Population Groups -- psychology KW - Ethnic Groups -- psychology KW - Diagnostic and Statistical Manual of Mental Disorders KW - Alcohol-Related Disorders -- psychology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733093993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing&rft.atitle=Vial+design+makes+tampering+easy&rft.au=Cohen%2C+Michael+R%2C+ScD%2C+MS%2C+RPH&rft.aulast=Cohen&rft.aufirst=Michael&rft.date=2015-09-01&rft.volume=45&rft.issue=9&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Nursing&rft.issn=03604039&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-11 N1 - Date created - 2009-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1530-0277.2009.00910.x ER - TY - JOUR T1 - Drug-abuse deterrent formulations. AN - 67422061; 19555144 AB - Prescription drug abuse is a large and growing problem. In the decade between 1992 and 2002, prescriptions for controlled substances increased roughly three times faster than prescriptions for noncontrolled substances and 12 times faster than the general population. With drug/formulation tampering now a prevalent problem, regulators and manufacturers have turned to the manufacturing process for ways to decrease the likelihood that a specific formulation is abuse-ready. Abuse-deterrent formulations are one aspect of a comprehensive approach to prescription drug risk management. Several approaches seem most likely to deter misuse and abuse: adding agonists or excipients that foil tampering efforts, using physical barriers, and designing prodrugs. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Wick, Jeannette Y AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 356 EP - 62, 365 VL - 24 IS - 5 SN - 0888-5109, 0888-5109 KW - Excipients KW - 0 KW - Prescription Drugs KW - Prodrugs KW - Index Medicus KW - Risk Management -- methods KW - Humans KW - Excipients -- chemistry KW - Drug and Narcotic Control -- legislation & jurisprudence KW - Prodrugs -- administration & dosage KW - Prescription Drugs -- adverse effects KW - Prescription Drugs -- administration & dosage KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67422061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Home+Healthcare+Now&rft.atitle=Ingestion+or+Aspiration+of+Foreign+Objects+or+Toxic+Substances+Is+Not+Just+a+Safety+Concern+With+Children&rft.au=Shastay%2C+Ann%2C+MSN%2C+RN%2C+AOCN&rft.aulast=Shastay&rft.aufirst=Ann&rft.date=2015-02-01&rft.volume=33&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Home+Healthcare+Now&rft.issn=23744529&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An evaluation by midwives and gynecologists of treatability of cervical lesions by cryotherapy among human papillomavirus-positive women. AN - 67354931; 19509579 AB - To estimate efficacy of a visual triage of human papillomavirus (HPV)-positive women to either immediate cryotherapy or referral if not treatable (eg, invasive cancer, large precancers). We evaluated visual triage in the HPV-positive women aged 25 to 55 years from the 10,000-woman Guanacaste Cohort Study (n = 552). Twelve Peruvian midwives and 5 international gynecologists assessed treatability by cryotherapy using digitized high-resolution cervical images taken at enrollment. The reference standard of treatability was determined by 2 lead gynecologists from the entire 7-year follow-up of the women. Women diagnosed with histologic cervical intraepithelial neoplasia grade 2 or worse or 5-year persistence of carcinogenic HPV infection were defined as needing treatment. Midwives and gynecologists judged 30.8% and 41.2% of women not treatable by cryotherapy, respectively (P < 0.01). Among 149 women needing treatment, midwives and gynecologists correctly identified 57.5% and 63.8% (P = 0.07 for difference) of 71 women judged not treatable by the lead gynecologists and 77.6% and 59.7% (P < 0.01 for difference) of 78 women judged treatable by cryotherapy. The proportion of women judged not treatable by a reviewer varied widely and ranged from 18.6% to 61.1%. Interrater agreement was poor with mean pairwise overall agreement of 71.4% and 66.3% and kappa's of 0.33 and 0.30 for midwives and gynecologists, respectively. In future "screen-and-treat" cervical cancer prevention programs using HPV testing and cryotherapy, practitioners will visually triage HPV-positive women. The suboptimal performance of visual triage suggests that screen-and-treat programs using cryotherapy might be insufficient for treating precancerous lesions. Improved, low-technology triage methods and/or improved safe and low-technology treatment options are needed. JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society AU - Gage, Julia C AU - Rodriguez, Ana Cecilia AU - Schiffman, Mark AU - Adadevoh, Sydney AU - Larraondo, Manuel J Alvarez AU - Chumworathayi, Bandit AU - Lejarza, Sandra Vargas AU - Araya, Luis Villegas AU - Garcia, Francisco AU - Budihas, Scott R AU - Long, Rodney AU - Katki, Hormuzd A AU - Herrero, Rolando AU - Burk, Robert D AU - Jeronimo, Jose AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA. gagej@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 728 EP - 733 VL - 19 IS - 4 KW - Index Medicus KW - Gynecology KW - Triage KW - Humans KW - Adult KW - Middle Aged KW - Female KW - Papillomavirus Infections -- pathology KW - Uterine Cervical Neoplasms -- therapy KW - Uterine Cervical Diseases -- therapy KW - Papillomavirus Infections -- diagnosis KW - Uterine Cervical Diseases -- diagnosis KW - Papillomavirus Infections -- therapy KW - Cryotherapy KW - Uterine Cervical Neoplasms -- diagnosis KW - Uterine Cervical Diseases -- virology KW - Uterine Cervical Diseases -- pathology KW - Papillomavirus Infections -- virology KW - Midwifery KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67354931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.atitle=An+evaluation+by+midwives+and+gynecologists+of+treatability+of+cervical+lesions+by+cryotherapy+among+human+papillomavirus-positive+women.&rft.au=Gage%2C+Julia+C%3BRodriguez%2C+Ana+Cecilia%3BSchiffman%2C+Mark%3BAdadevoh%2C+Sydney%3BLarraondo%2C+Manuel+J+Alvarez%3BChumworathayi%2C+Bandit%3BLejarza%2C+Sandra+Vargas%3BAraya%2C+Luis+Villegas%3BGarcia%2C+Francisco%3BBudihas%2C+Scott+R%3BLong%2C+Rodney%3BKatki%2C+Hormuzd+A%3BHerrero%2C+Rolando%3BBurk%2C+Robert+D%3BJeronimo%2C+Jose&rft.aulast=Gage&rft.aufirst=Julia&rft.date=2009-05-01&rft.volume=19&rft.issue=4&rft.spage=728&rft.isbn=&rft.btitle=&rft.title=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.issn=1525-1438&rft_id=info:doi/10.1111%2FIGC.0b013e3181a48b99 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-25 N1 - Date created - 2009-06-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Obstet Gynecol. 2001 Sep;98(3):441-4 [11530126] J Low Genit Tract Dis. 2009 Jul;13(3):174-81 [19550216] Cancer Detect Prev. 2003;27(6):466-71 [14642555] Rev Panam Salud Publica. 2004 Feb;15(2):75-89 [15030652] Rev Panam Salud Publica. 1997 May;1(5):362-75 [9180057] Lancet. 1999 Mar 13;353(9156):869-73 [10093978] Cancer Detect Prev. 2004;28(5):345-51 [15542259] JAMA. 2005 Nov 2;294(17):2173-81 [16264158] J Low Genit Tract Dis. 2006 Jan;10(1):16-25 [16378028] J Low Genit Tract Dis. 2006 Jan;10(1):39-44 [16378030] Obstet Gynecol. 2006 Aug;108(2):264-72 [16880294] Int J Cancer. 2006 Sep 15;119(6):1389-95 [16619217] Int J Cancer. 2007 Aug 15;121(4):796-802 [17437272] Rev Panam Salud Publica. 2008 Jan;23(1):1-6 [18291067] J Natl Cancer Inst. 2008 Apr 2;100(7):513-7 [18364507] Gynecol Oncol. 2008 Sep;110(3):402-7 [18556050] Lancet Oncol. 2008 Oct;9(10):929-36 [18805733] J Low Genit Tract Dis. 2009 Jul;13(3):137-44 [19550210] J Med Virol. 2002 Nov;68(3):417-23 [12226831] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/IGC.0b013e3181a48b99 ER - TY - JOUR T1 - Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure. AN - 67305774; 19479012 AB - Hexavalent chromium [Cr(VI)] is a human carcinogen after inhalation exposure. Humans also ingest Cr(VI) from contaminated drinking water and soil; however, limited data exist on the oral toxicity and carcinogenicity of Cr(VI). We characterized the chronic oral toxicity and carcinogenicity of Cr(VI) in rodents. The National Toxicology Program (NTP) conducted 2-year drinking water studies of Cr(VI) (as sodium dichromate dihydrate) in male and female F344/N rats and B6C3F1 mice. Cr(VI) exposure resulted in increased incidences of rare neoplasms of the squamous epithelium that lines the oral cavity (oral mucosa and tongue) in male and female rats, and of the epithelium lining the small intestine in male and female mice. Cr(VI) exposure did not affect survival but resulted in reduced mean body weights and water consumption, due at least in part to poor palatability of the dosed water. Cr(VI) exposure resulted in transient microcytic hypochromic anemia in rats and microcytosis in mice. Nonneoplastic lesions included diffuse epithelial hyperplasia in the duodenum and jejunum of mice and histiocytic cell infiltration in the duodenum, liver, and mesenteric and pancreatic lymph nodes of rats and mice. Cr(VI) was carcinogenic after administration in drinking water to male and female rats and mice. JF - Environmental health perspectives AU - Stout, Matthew D AU - Herbert, Ronald A AU - Kissling, Grace E AU - Collins, Bradley J AU - Travlos, Gregory S AU - Witt, Kristine L AU - Melnick, Ronald L AU - Abdo, Kamal M AU - Malarkey, David E AU - Hooth, Michelle J AD - National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 , USA. hooth@niehs.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 716 EP - 722 VL - 117 IS - 5 KW - Carcinogens KW - 0 KW - Chromium KW - 0R0008Q3JB KW - chromium hexavalent ion KW - 18540-29-9 KW - Index Medicus KW - hexavalent chromium KW - small intestine KW - anemia KW - National Toxicology Program KW - oral cavity KW - histiocytic cellular infiltration KW - cancer KW - Rats KW - Administration, Oral KW - Animals KW - Rats, Inbred F344 KW - Mice KW - Male KW - Female KW - Mouth -- drug effects KW - Mouth Neoplasms -- chemically induced KW - Carcinogens -- administration & dosage KW - Carcinoma, Squamous Cell -- pathology KW - Carcinogens -- toxicity KW - Carcinoma, Squamous Cell -- chemically induced KW - Chromium -- toxicity KW - Mouth Neoplasms -- pathology KW - Mouth -- pathology KW - Chromium -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67305774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Hexavalent+chromium+is+carcinogenic+to+F344%2FN+rats+and+B6C3F1+mice+after+chronic+oral+exposure.&rft.au=Stout%2C+Matthew+D%3BHerbert%2C+Ronald+A%3BKissling%2C+Grace+E%3BCollins%2C+Bradley+J%3BTravlos%2C+Gregory+S%3BWitt%2C+Kristine+L%3BMelnick%2C+Ronald+L%3BAbdo%2C+Kamal+M%3BMalarkey%2C+David+E%3BHooth%2C+Michelle+J&rft.aulast=Stout&rft.aufirst=Matthew&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=716&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0800208 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-09 N1 - Date created - 2009-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 2000 Apr;21(4):533-41 [10753182] Natl Toxicol Program Tech Rep Ser. 2010 Jun;(556):1-194 [20725156] Acta Vet Hung. 2001;49(2):203-9 [11402649] J Toxicol Environ Health A. 2002 May 24;65(10):701-46 [12028825] Mutat Res. 2003 Dec 10;533(1-2):3-36 [14643411] J Lab Clin Med. 1966 Sep;68(3):484-93 [5922758] Arch Hyg Bakteriol. 1968 Jan;152(1):45-53 [5707368] Biometrics. 1977 Jun;33(2):386-9 [884197] J Natl Cancer Inst. 1986 Feb;76(2):283-9 [3456066] Biometrics. 1986 Mar;42(1):183-6 [3719054] Zhonghua Yu Fang Yi Xue Za Zhi. 1987 Sep;21(5):262-4 [3443034] Biometrics. 1988 Jun;44(2):417-31 [3390507] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Mutat Res. 1990 Mar;238(2):99-172 [2407950] Mutat Res. 1991 Jan;262(1):41-6 [1986283] Chem Res Toxicol. 1991 Nov-Dec;4(6):616-25 [1807444] Crit Rev Toxicol. 1993;23(3):255-81 [8260068] Carcinogenesis. 1997 Mar;18(3):531-7 [9067553] Crit Rev Toxicol. 1997 Sep;27(5):431-42 [9347224] Chem Res Toxicol. 2005 Jan;18(1):3-11 [15651842] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2006 Apr;24(1):155-82 [16690539] Crit Rev Toxicol. 2006 Feb;36(2):155-63 [16736941] Carcinogenesis. 2006 Nov;27(11):2316-21 [16714765] Nucleic Acids Res. 2007;35(2):465-76 [17169990] Toxic Rep Ser. 2007 Jan;(72):1-G4 [17342194] Epidemiology. 2008 Jan;19(1):12-23 [18091413] Mutat Res. 2008 Jul-Aug;659(1-2):60-7 [18155955] Natl Toxicol Program Tech Rep Ser. 2008 Jul;(546):1-192 [18716633] Environ Health Perspect. 2000 Sep;108(9):A402-7 [11017901] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0800208 ER - TY - JOUR T1 - The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS). AN - 67303004; 19478875 AB - Anthrax lethal toxin (LT) induces vascular insufficiency in experimental animals through unknown mechanisms. In this study, we show that neuronal nitric oxide synthase (nNOS) deficiency in mice causes strikingly increased sensitivity to LT, while deficiencies in the two other NOS enzymes (iNOS and eNOS) have no effect on LT-mediated mortality. The increased sensitivity of nNOS-/- mice was independent of macrophage sensitivity to toxin, or cytokine responses, and could be replicated in nNOS-sufficient wild-type (WT) mice through pharmacological inhibition of the enzyme with 7-nitroindazole. Histopathological analyses showed that LT induced architectural changes in heart morphology of nNOS-/- mice, with rapid appearance of novel inter-fiber spaces but no associated apoptosis of cardiomyocytes. LT-treated WT mice had no histopathology observed at the light microscopy level. Electron microscopic analyses of LT-treated mice, however, revealed striking pathological changes in the hearts of both nNOS-/- and WT mice, varying only in severity and timing. Endothelial/capillary necrosis and degeneration, inter-myocyte edema, myofilament and mitochondrial degeneration, and altered sarcoplasmic reticulum cisternae were observed in both LT-treated WT and nNOS-/- mice. Furthermore, multiple biomarkers of cardiac injury (myoglobin, cardiac troponin-I, and heart fatty acid binding protein) were elevated in LT-treated mice very rapidly (by 6 h after LT injection) and reached concentrations rarely reported in mice. Cardiac protective nitrite therapy and allopurinol therapy did not have beneficial effects in LT-treated mice. Surprisingly, the potent nitric oxide scavenger, carboxy-PTIO, showed some protective effect against LT. Echocardiography on LT-treated mice indicated an average reduction in ejection fraction following LT treatment in both nNOS-/- and WT mice, indicative of decreased contractile function in the heart. We report the heart as an early target of LT in mice and discuss a protective role for nNOS against LT-mediated cardiac damage. JF - PLoS pathogens AU - Moayeri, Mahtab AU - Crown, Devorah AU - Dorward, David W AU - Gardner, Don AU - Ward, Jerrold M AU - Li, Yan AU - Cui, Xizhong AU - Eichacker, Peter AU - Leppla, Stephen H AD - Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1 VL - 5 IS - 5 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Free Radical Scavengers KW - anthrax toxin KW - Nitric Oxide Synthase Type I KW - EC 1.14.13.39 KW - Nos1 protein, mouse KW - Index Medicus KW - Animals KW - Myocardium -- pathology KW - Endothelium, Vascular -- pathology KW - Mice KW - Myocytes, Cardiac -- pathology KW - Free Radical Scavengers -- pharmacology KW - Stroke Volume KW - Mice, Knockout KW - Nitric Oxide Synthase Type I -- physiology KW - Heart -- virology KW - Bacterial Toxins -- poisoning KW - Antigens, Bacterial -- poisoning KW - Nitric Oxide Synthase Type I -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67303004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+pathogens&rft.atitle=The+heart+is+an+early+target+of+anthrax+lethal+toxin+in+mice%3A+a+protective+role+for+neuronal+nitric+oxide+synthase+%28nNOS%29.&rft.au=Moayeri%2C+Mahtab%3BCrown%2C+Devorah%3BDorward%2C+David+W%3BGardner%2C+Don%3BWard%2C+Jerrold+M%3BLi%2C+Yan%3BCui%2C+Xizhong%3BEichacker%2C+Peter%3BLeppla%2C+Stephen+H&rft.aulast=Moayeri&rft.aufirst=Mahtab&rft.date=2009-05-01&rft.volume=5&rft.issue=5&rft.spage=e1000456&rft.isbn=&rft.btitle=&rft.title=PLoS+pathogens&rft.issn=1553-7374&rft_id=info:doi/10.1371%2Fjournal.ppat.1000456 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-15 N1 - Date created - 2009-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1984 Sep;45(3):761-7 [6432700] J Biol Chem. 1996 Sep 13;271(37):22810-4 [8798458] Cell Calcium. 1997 Jan;21(1):19-29 [9056074] Cell Calcium. 1997 Dec;22(6):447-54 [9502194] Mol Med. 1998 Feb;4(2):87-95 [9508786] Science. 1998 May 1;280(5364):734-7 [9563949] J Physiol. 1998 Aug 15;511 ( Pt 1):273-87 [9679181] Eur Heart J. 1998 Nov;19 Suppl N:N12-5 [9857933] Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):657-62 [9892689] Nat Med. 1999 Mar;5(3):320-6 [10086389] Mol Cell Biochem. 2004 Aug;263(1-2):35-53 [15524166] Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15944-8 [15486091] J Infect Dis. 2005 Feb 1;191(3):422-34 [15633102] Circ Res. 2005 Feb 18;96(3):355-62 [15637297] J Biol Chem. 2008 Jan 4;283(1):529-40 [17974567] Cardiovasc Res. 2008 Jan 15;77(2):256-64 [18006480] Toxicology. 2008 Mar 20;245(3):206-18 [18249481] Arch Biochem Biophys. 2008 Apr 1;472(1):58-64 [18269913] Curr Top Microbiol Immunol. 2008;323:315-35 [18357777] Circulation. 2008 Apr 15;117(15):1991-6 [18391107] Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L830-40 [18344415] Microb Pathog. 2008 Jun;44(6):467-72 [18222626] Circulation. 2008 Jun 24;117(25):3187-98 [18541744] PLoS One. 2008;3(9):e3130 [18769623] Trends Cardiovasc Med. 2008 Jul;18(5):163-72 [18790386] Expert Rev Cardiovasc Ther. 2008 Oct;6(9):1175-9 [18939904] Cardiovasc Res. 2009 Feb 1;81(2):389-99 [18987049] Clin Exp Pharmacol Physiol. 2008 Apr;35(4):483-8 [18307746] Am J Pathol. 2005 Jun;166(6):1871-81 [15920171] Eur Heart J. 2005 Aug;26(15):1458-60 [15917281] Circulation. 2000 Oct 31;102(18):2276-81 [11056105] Biochem J. 2000 Dec 15;352 Pt 3:739-45 [11104681] Int J Med Microbiol. 2000 Oct;290(4-5):421-7 [11111921] Cancer Res. 2001 Sep 15;61(18):6649-55 [11559528] Pharmacol Res. 2005 May;51(5):409-17 [15749455] Pharmacol Ther. 2005 May;106(2):147-62 [15866317] CMAJ. 2005 Nov 8;173(10):1191-202 [16275971] J Clin Invest. 2005 Nov;115(11):3128-39 [16276418] Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2502-8 [16224055] Circulation. 2005 Dec 13;112(24):3729-37 [16344403] Infect Immun. 2006 Feb;74(2):1266-72 [16428776] Arch Mal Coeur Vaiss. 2005 Dec;98(12):1244-8 [16435605] Infect Immun. 2006 Apr;74(4):2268-76 [16552057] Lab Anim. 2006 Apr;40(2):153-71 [16600075] Expert Rev Mol Diagn. 2006 Sep;6(5):685-702 [17009904] Exp Physiol. 2006 Nov;91(6):943-55 [16990366] Circ Res. 2007 Feb 16;100(3):e32-44 [17272813] PLoS One. 2007;2(5):e466 [17520025] Crit Care Med. 2007 Jun;35(6):1560-7 [17452924] Cardiology. 2007;108(1):4-10 [16960442] Cardiovasc Res. 2007 Jul 15;75(2):283-90 [17466959] Cardiovasc Res. 2007 Jul 15;75(2):327-38 [17568573] Cardiovasc Res. 2007 Jul 15;75(2):315-26 [17568574] J Exp Med. 2007 Sep 3;204(9):2089-102 [17682069] Intensive Care Med. 2007 Nov;33(11):1993-2003 [17684724] Eur Heart J. 2007 Nov;28(22):2792-8 [17602202] J Cell Sci. 2001 Aug;114(Pt 15):2755-73 [11683410] Biochem Biophys Res Commun. 2002 Mar 22;292(1):41-4 [11890668] Nature. 2002 Mar 21;416(6878):337-9 [11907582] Circulation. 2002 Jun 25;105(25):3011-6 [12081996] Circ Res. 2002 Nov 1;91(9):776-81 [12411391] FASEB J. 2002 Dec;16(14):1994-6 [12397095] Circ Res. 2003 Mar 21;92(5):e52-9 [12623875] Circ Res. 2003 Jun 27;92(12):1322-9 [12764022] J Clin Invest. 2003 Sep;112(5):670-82 [12952916] FASEB J. 2003 Oct;17(13):1934-6 [12897062] Infect Immun. 2004 Jan;72(1):430-9 [14688124] Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R699-709 [14715494] J Physiol. 2004 Mar 16;555(Pt 3):589-606 [14694147] QJM. 2004 Apr;97(4):187-98 [15028848] Lancet. 2004 Apr 24;363(9418):1365-7 [15110495] J Atheroscler Thromb. 2004;11(2):41-8 [15153662] J Cell Sci. 2004 Jun 1;117(Pt 13):2627-9 [15169833] Drug Metab Rev. 2004 May;36(2):363-75 [15237859] Infect Immun. 2004 Aug;72(8):4439-47 [15271901] Philos Trans R Soc Lond B Biol Sci. 2004 Jun 29;359(1446):1021-44 [15306414] Microbes Infect. 2004 Jul;6(9):835-43 [15374005] Circulation. 2004 Oct 19;110(16):2368-75 [15466641] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.ppat.1000456 ER - TY - JOUR T1 - Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for Leishmania. AN - 67280211; 19461875 AB - Immunity to a sand fly salivary protein protects against visceral leishmaniasis (VL) in hamsters. This protection was associated with the development of cellular immunity in the form of a delayed-type hypersensitivity response and the presence of IFN-gamma at the site of sand fly bites. To date, there are no data available regarding the cellular immune response to sand fly saliva in dogs, the main reservoirs of VL in Latin America, and its role in protection from this fatal disease. Two of 35 salivary proteins from the vector sand fly Lutzomyia longipalpis, identified using a novel approach termed reverse antigen screening, elicited strong cellular immunity in dogs. Immunization with either molecule induced high IgG(2) antibody levels and significant IFN-gamma production following in vitro stimulation of PBMC with salivary gland homogenate (SGH). Upon challenge with uninfected or infected flies, immunized dogs developed a cellular response at the bite site characterized by lymphocytic infiltration and IFN-gamma and IL-12 expression. Additionally, SGH-stimulated lymphocytes from immunized dogs efficiently killed Leishmania infantum chagasi within autologous macrophages. Certain sand fly salivary proteins are potent immunogens obligatorily co-deposited with Leishmania parasites during transmission. Their inclusion in an anti-Leishmania vaccine would exploit anti-saliva immunity following an infective sand fly bite and set the stage for a protective anti-Leishmania immune response. JF - PLoS pathogens AU - Collin, Nicolas AU - Gomes, Regis AU - Teixeira, Clarissa AU - Cheng, Lily AU - Laughinghouse, Andre AU - Ward, Jerrold M AU - Elnaiem, Dia-Eldin AU - Fischer, Laurent AU - Valenzuela, Jesus G AU - Kamhawi, Shaden AD - Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1 VL - 5 IS - 5 KW - Cytokines KW - 0 KW - Insect Proteins KW - Recombinant Proteins KW - Salivary Proteins and Peptides KW - Index Medicus KW - Psychodidae -- genetics KW - Insect Vectors -- parasitology KW - Animals KW - Cytokines -- genetics KW - Gene Expression KW - Antibody Formation KW - Cytokines -- metabolism KW - Recombinant Proteins -- genetics KW - Lymphocytes -- immunology KW - Insect Vectors -- immunology KW - Hypersensitivity, Delayed KW - Immunity, Cellular KW - Insect Bites and Stings -- immunology KW - Recombinant Proteins -- metabolism KW - Skin -- immunology KW - Recombinant Proteins -- immunology KW - Dogs KW - Insect Vectors -- genetics KW - Data Interpretation, Statistical KW - Psychodidae -- parasitology KW - Psychodidae -- immunology KW - Female KW - Salivary Proteins and Peptides -- metabolism KW - Salivary Proteins and Peptides -- immunology KW - Insect Proteins -- genetics KW - Leishmania infantum -- immunology KW - Salivary Proteins and Peptides -- genetics KW - Leishmania infantum -- physiology KW - Insect Proteins -- immunology KW - Leishmaniasis, Visceral -- immunology KW - Insect Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67280211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+pathogens&rft.atitle=Sand+fly+salivary+proteins+induce+strong+cellular+immunity+in+a+natural+reservoir+of+visceral+leishmaniasis+with+adverse+consequences+for+Leishmania.&rft.au=Collin%2C+Nicolas%3BGomes%2C+Regis%3BTeixeira%2C+Clarissa%3BCheng%2C+Lily%3BLaughinghouse%2C+Andre%3BWard%2C+Jerrold+M%3BElnaiem%2C+Dia-Eldin%3BFischer%2C+Laurent%3BValenzuela%2C+Jesus+G%3BKamhawi%2C+Shaden&rft.aulast=Collin&rft.aufirst=Nicolas&rft.date=2009-05-01&rft.volume=5&rft.issue=5&rft.spage=e1000441&rft.isbn=&rft.btitle=&rft.title=PLoS+pathogens&rft.issn=1553-7374&rft_id=info:doi/10.1371%2Fjournal.ppat.1000441 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-14 N1 - Date created - 2009-05-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2000 Nov 17;290(5495):1351-4 [11082061] Expert Rev Vaccines. 2008 Aug;7(6):833-51 [18665780] J Infect Dis. 2002 Nov 15;186(10):1530-4 [12404176] Nat Rev Immunol. 2002 Nov;2(11):845-58 [12415308] J Exp Biol. 2004 Oct;207(Pt 21):3717-29 [15371479] Nat Rev Microbiol. 2004 Sep;2(9):692 [15378809] Dev Biol Stand. 1994;82:65-9 [7958484] J Exp Med. 1998 Nov 16;188(10):1941-53 [9815271] Vaccine. 2005 Apr 22;23(22):2825-40 [15780731] Vaccine. 2005 Sep 23;23(40):4805-10 [16011864] Vaccine. 2006 Jan 16;24(3):374-90 [16154670] Indian J Med Res. 2006 Mar;123(3):289-94 [16778311] Trends Parasitol. 2006 Dec;22(12):552-7 [17023215] Epidemiol Infect. 2007 Feb;135(2):195-201 [16824254] Vaccine. 2007 Mar 8;25(12):2180-6 [17239495] Nat Rev Microbiol. 2007 Nov;5(11):873-82 [17938629] Eur J Immunol. 2007 Nov;37(11):3111-21 [17935072] Vaccine. 2008 Jan 30;26(5):623-38 [18180079] Vaccine. 2008 Mar 25;26(14):1709-24 [18295939] PLoS Negl Trop Dis. 2008;2(4):e226 [18414648] Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7845-50 [18509051] Trends Parasitol. 2008 Jul;24(7):324-30 [18514028] J Vector Borne Dis. 2008 Jun;45(2):105-11 [18592839] Emerg Infect Dis. 2008 Jul;14(7):1013-8 [18598618] Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10125-30 [18626016] J Exp Med. 2001 Aug 6;194(3):331-42 [11489952] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.ppat.1000441 ER - TY - JOUR T1 - Detection and characterization of a glutathione conjugate of a novel copper complex. AN - 67279100; 19454505 AB - Glutathione (GSH), an important component of the phase II detoxification system, plays a major role in storage, metabolism and transport of metals across the cell membrane. The role of copper, its metabolism and storage in living systems is not completely understood. Copper plays an important role in a number of physiological processes, e.g. several growth and transcription factors require copper for activity. In the present investigation, we focused on copper (II) (N-2-hydroxyacetophenone) glycinate (CuNG), a novel in vitro and in vivo resistance modifying agent. A conjugate of GSH and CuNG was detected in vivo in mice and was characterized by spectroscopic studies. Based on UV, IR, proton NMR and elemental analyses, the chemical structure of the conjugate was elucidated. By means of atomic absorption data, the distribution and metabolism of CuNG is described. JF - In vivo (Athens, Greece) AU - Basu, Soumya AU - Majumder, S AU - Chatterjee, S AU - Ganguly, A AU - Efferth, T AU - Choudhuri, S K AD - Department of In-vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, Calcutta-700 026, India. PY - 2009 SP - 401 EP - 408 VL - 23 IS - 3 SN - 0258-851X, 0258-851X KW - Copper KW - 789U1901C5 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Models, Molecular KW - Chromatography, Liquid KW - Spectrum Analysis -- methods KW - Mice KW - Male KW - Glutathione -- metabolism KW - Copper -- metabolism KW - Glutathione -- chemistry KW - Copper -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67279100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=Detection+and+characterization+of+a+glutathione+conjugate+of+a+novel+copper+complex.&rft.au=Basu%2C+Soumya%3BMajumder%2C+S%3BChatterjee%2C+S%3BGanguly%2C+A%3BEfferth%2C+T%3BChoudhuri%2C+S+K&rft.aulast=Basu&rft.aufirst=Soumya&rft.date=2009-05-01&rft.volume=23&rft.issue=3&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-14 N1 - Date created - 2009-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of CREB function in mouse epidermis reduces papilloma formation. AN - 67266097; 19435810 AB - We used a double transgenic tetracycline system to conditionally express A-CREB, a dominant negative protein that prevents the DNA binding and function of cAMP-responsive element binding protein (CREB) family members, in mouse basal epidermis using the keratin 5 promoter. There was no phenotype in the adult. However, following a 7,12-dimethylbenz(a)anthracene (DMBA)/phorbol-12-myristate-13-acetate two-stage skin carcinogenesis experiment, A-CREB-expressing epidermis develop 5-fold fewer papillomas than wild-type controls. However, A-CREB expression one month after DMBA treatment does not prevent papilloma formation, suggesting that CREB functions at an early stage of papilloma formation. Oncogenic H-Ras genes with A-->T mutations in codon 61 were found in wild-type skin but not in A-CREB-expressing skin 2 days after DMBA treatment, suggesting that A-CREB either prevents DMBA mutagenesis or kills oncogenic H-Ras cells. In primary keratinocyte cultures, A-CREB expression induced apoptosis of v-Ras(Ha)-infected cells and suppressed the expression of cell cycle proteins cyclin B1 and cyclin D1. These results suggest that inhibiting CREB function is a valuable cancer prevention strategy. JF - Molecular cancer research : MCR AU - Rozenberg, Julian AU - Rishi, Vikas AU - Orosz, Andras AU - Moitra, Jaideep AU - Glick, Adam AU - Vinson, Charles AD - Laboratory of Metabolism, National Cancer Institute, NIH, 37 Convent Drive, Room 2D24, Bethesda, MD 20892, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 654 EP - 664 VL - 7 IS - 5 SN - 1541-7786, 1541-7786 KW - Carcinogens KW - 0 KW - Cyclic AMP Response Element-Binding Protein KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Tetradecanoylphorbol Acetate -- toxicity KW - Animals KW - Skin -- metabolism KW - Apoptosis -- physiology KW - Cell Cycle -- physiology KW - Skin -- pathology KW - Carcinogens -- toxicity KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Transgenic KW - Cell Proliferation KW - Mice, Inbred Strains KW - Animals, Newborn KW - In Situ Nick-End Labeling KW - Blotting, Western KW - Skin -- drug effects KW - Genes, ras -- genetics KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Cells, Cultured KW - Keratinocytes -- cytology KW - Keratinocytes -- metabolism KW - Mutation KW - Male KW - Female KW - Skin Neoplasms -- genetics KW - Epidermis -- drug effects KW - Cyclic AMP Response Element-Binding Protein -- metabolism KW - Skin Neoplasms -- chemically induced KW - Cyclic AMP Response Element-Binding Protein -- physiology KW - Cyclic AMP Response Element-Binding Protein -- genetics KW - Epidermis -- metabolism KW - Epidermis -- pathology KW - Papilloma -- genetics KW - Skin Neoplasms -- metabolism KW - Papilloma -- chemically induced KW - Papilloma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67266097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+research+%3A+MCR&rft.atitle=Inhibition+of+CREB+function+in+mouse+epidermis+reduces+papilloma+formation.&rft.au=Rozenberg%2C+Julian%3BRishi%2C+Vikas%3BOrosz%2C+Andras%3BMoitra%2C+Jaideep%3BGlick%2C+Adam%3BVinson%2C+Charles&rft.aulast=Rozenberg&rft.aufirst=Julian&rft.date=2009-05-01&rft.volume=7&rft.issue=5&rft.spage=654&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+research+%3A+MCR&rft.issn=15417786&rft_id=info:doi/10.1158%2F1541-7786.MCR-08-0011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-23 N1 - Date created - 2009-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1541-7786.MCR-08-0011 ER - TY - JOUR T1 - The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases delta and eta. AN - 67263732; 19282446 AB - A DNA lesion created by oxidative stress is 7,8-dihydro-8-oxo-guanine (8-oxoG). Because 8-oxoG can mispair with adenine during DNA synthesis, it is of interest to understand the efficiency and fidelity of 8-oxoG bypass by DNA polymerases. We quantify bypass parameters for two DNA polymerases implicated in 8-oxoG bypass, Pols delta and eta. Yeast Pol delta and yeast Pol eta both bypass 8-oxoG and misincorporate adenine during bypass. However, yeast Pol eta is 10-fold more efficient than Pol delta, and following bypass Pol eta switches to less processive synthesis, similar to that observed during bypass of a cis-syn thymine-thymine dimer. Moreover, yeast Pol eta is at least 10-fold more accurate than yeast Pol delta during 8-oxoG bypass. These differences are maintained in the presence of the accessory proteins RFC, PCNA and RPA and are consistent with the established role of Pol eta in suppressing ogg1-dependent mutagenesis in yeast. Surprisingly different results are obtained with human and mouse Pol eta. Both mammalian enzymes bypass 8-oxoG efficiently, but they do so less processively, without a switch point and with much lower fidelity than yeast Pol eta. The fact that yeast and mammalian Pol eta have intrinsically different catalytic properties has potential biological implications. JF - Nucleic acids research AU - McCulloch, Scott D AU - Kokoska, Robert J AU - Garg, Parie AU - Burgers, Peter M AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences Research, NC 27709, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 2830 EP - 2840 VL - 37 IS - 9 KW - 8-hydroxyguanine KW - 5614-64-2 KW - Guanine KW - 5Z93L87A1R KW - DNA KW - 9007-49-2 KW - DNA Polymerase III KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Rad30 protein KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Saccharomyces cerevisiae -- enzymology KW - DNA -- biosynthesis KW - Guanine -- chemistry KW - Guanine -- analogs & derivatives KW - DNA Polymerase III -- metabolism KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67263732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=The+efficiency+and+fidelity+of+8-oxo-guanine+bypass+by+DNA+polymerases+delta+and+eta.&rft.au=McCulloch%2C+Scott+D%3BKokoska%2C+Robert+J%3BGarg%2C+Parie%3BBurgers%2C+Peter+M%3BKunkel%2C+Thomas+A&rft.aulast=McCulloch&rft.aufirst=Scott&rft.date=2009-05-01&rft.volume=37&rft.issue=9&rft.spage=2830&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkp103 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-14 N1 - Date created - 2009-05-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1998 Jul 31;273(31):19756-62 [9677406] Nucleic Acids Res. 1999 Jan 15;27(2):496-502 [9862971] J Biol Chem. 1999 Jun 4;274(23):15975-7 [10347143] EMBO J. 1999 Jun 15;18(12):3491-501 [10369688] Genetics. 2005 Feb;169(2):575-82 [15520252] Mol Cell Biol. 2005 Mar;25(6):2169-76 [15743815] Mol Cell. 2005 May 27;18(5):499-505 [15916957] Genes Cells. 2005 Jun;10(6):543-50 [15938713] J Biol Chem. 2005 Aug 19;280(33):29980-7 [15964835] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13538-43 [16157879] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18361-6 [16344468] Cancer Res. 2006 Jan 1;66(1):87-94 [16397220] J Biol Chem. 2006 Jan 27;281(4):2358-72 [16306039] Curr Biol. 2006 Jan 24;16(2):202-7 [16431373] PLoS Biol. 2006 Jan;4(1):e11 [16379496] Methods Enzymol. 2006;408:341-55 [16793379] Nucleic Acids Res. 2006;34(16):4335-41 [16936322] Nature. 2007 May 31;447(7144):606-8 [17507928] Biochemistry. 2007 Jul 31;46(30):8888-96 [17608453] DNA Repair (Amst). 2007 Dec 1;6(12):1829-38 [17715002] Mutat Res. 2008 May 10;641(1-2):19-26 [18359049] Nucleic Acids Res. 2008 Jul;36(12):3892-904 [18503083] Nucleic Acids Res. 2008 Oct;36(17):5660-7 [18772226] Cell. 1999 Oct 15;99(2):155-66 [10535734] Biochemistry. 2000 Feb 8;39(5):1029-33 [10653647] Carcinogenesis. 2000 Mar;21(3):361-70 [10688856] J Biol Chem. 2000 Mar 17;275(11):8233-9 [10713149] Nature. 2000 Apr 27;404(6781):1011-3 [10801132] Nat Genet. 2000 Aug;25(4):458-61 [10932195] Nucleic Acids Res. 2000 Nov 1;28(21):4138-46 [11058110] Nucleic Acids Res. 2000 Dec 1;28(23):4717-24 [11095682] Mol Cell Biol. 2001 Jan;21(1):185-8 [11113193] J Biol Chem. 2001 Jan 26;276(4):2317-20 [11113111] J Biol Chem. 2001 Feb 9;276(6):3764-71 [11110788] J Mol Biol. 2001 Sep 14;312(2):335-46 [11554790] Nucleic Acids Res. 2002 Mar 1;30(5):1262-7 [11861920] J Biol Chem. 2002 Mar 8;277(10):8260-6 [11756455] Mutat Res. 2002 Dec 29;510(1-2):81-90 [12459445] Structure. 2003 Jan;11(1):121-7 [12517346] J Biol Chem. 2003 Jan 17;278(3):1618-25 [12424238] Cell. 2003 Feb 7;112(3):391-401 [12581528] J Invest Dermatol. 2003 Sep;121(3):435-40 [12925197] J Biol Chem. 2003 Dec 12;278(50):50537-45 [14523013] Nature. 2004 Mar 4;428(6978):97-100 [14999287] EMBO J. 2004 Apr 7;23(7):1494-505 [15057282] Nucleic Acids Res. 2004;32(15):4665-75 [15333698] EMBO J. 2004 Sep 1;23(17):3452-61 [15297882] Nature. 2004 Sep 9;431(7005):217-21 [15322558] Nucleic Acids Res. 2004;32(17):5003-10 [15388802] Nature. 1976 Jun 17;261(5561):593-5 [934300] Biochem Biophys Res Commun. 1976 Jul 12;71(1):228-34 [962915] Biochemistry. 1991 Jan 15;30(2):538-46 [1988042] Biochemistry. 1991 Feb 5;30(5):1403-12 [1991121] Nature. 1991 Jan 31;349(6308):431-4 [1992344] Nucleic Acids Res. 1991 Apr 11;19(7):1407-12 [2027747] Mol Cell Biol. 1992 Jan;12(1):155-63 [1346062] Bioessays. 1992 May;14(5):303-8 [1637361] J Biol Chem. 1994 Apr 15;269(15):11121-32 [8157639] Mutat Res. 1994 Aug;318(1):1-64 [7519315] Biochemistry. 1994 Aug 30;33(34):10266-70 [8068665] Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):719-23 [7846041] Methods Enzymol. 1995;262:217-32 [8594349] Biochemistry. 1996 Jul 30;35(30):9840-9 [8703958] Photochem Photobiol. 1997 Jan;65(1):119-24 [9066291] Carcinogenesis. 1997 Apr;18(4):811-6 [9111219] Biochemistry. 1997 May 27;36(21):6475-87 [9174365] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6126-31 [9177181] Nucleic Acids Res. 1998 Jan 1;26(1):205-13 [9399837] Genetics. 1997 Dec;147(4):1557-68 [9409821] Carcinogenesis. 1997 Dec;18(12):2379-84 [9450485] Mol Gen Genet. 1998 Apr;257(6):686-92 [9604893] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkp103 ER - TY - JOUR T1 - Emergencies related to cancer chemotherapy and hematopoietic stem cell transplantation. AN - 67249503; 19447314 AB - As a vast majority of oncologic treatments are being administered in the outpatient setting, emergency department (ED) physicians are increasingly encountering patients who present with a wide array of toxicities that are a direct effect of chemotherapy. This review aims to highlight the most often encountered and clinically relevant toxicities of the more commonly administered chemotherapeutic drugs. In addition, because stem cell transplantation is being used increasingly for various malignancies, a brief introduction to post-transplant complications is included. JF - Emergency medicine clinics of North America AU - Adelberg, David E AU - Bishop, Michael R AD - Medical Oncology Branch, National Cancer Institute, 10 Center Drive, CRC/Room 12N226, Bethesda, MD 20892, USA. adelbergd@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 311 EP - 331 VL - 27 IS - 2 KW - Index Medicus KW - Infection -- etiology KW - Graft vs Host Disease -- diagnosis KW - Infection -- diagnosis KW - Humans KW - Graft vs Host Disease -- drug therapy KW - Infection -- drug therapy KW - Immunocompromised Host KW - Emergency Service, Hospital KW - Graft vs Host Disease -- etiology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Neoplasms -- therapy KW - Hematopoietic Stem Cell Transplantation -- adverse effects KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67249503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emergency+medicine+clinics+of+North+America&rft.atitle=Emergencies+related+to+cancer+chemotherapy+and+hematopoietic+stem+cell+transplantation.&rft.au=Adelberg%2C+David+E%3BBishop%2C+Michael+R&rft.aulast=Adelberg&rft.aufirst=David&rft.date=2009-05-01&rft.volume=27&rft.issue=2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Emergency+medicine+clinics+of+North+America&rft.issn=1558-0539&rft_id=info:doi/10.1016%2Fj.emc.2009.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-04 N1 - Date created - 2009-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.emc.2009.01.005 ER - TY - JOUR T1 - Diadenosine tetraphosphate reduces toxicity caused by high-dose methamphetamine administration. AN - 67245286; 19442829 AB - Diadenosine tetraphosphate (AP(4)A), two adenosine moieties bridged by four phosphates, is an endogenous purinergic ligand found in brain. Previous studies have shown that AP(4)A reduced neurodegeneration caused by the dopaminergic neurotoxin 6-hydroxydopamine in rat striatum and substantia nigra. The purpose of this study was to determine whether AP(4)A is protective against methamphetamine (MA)-mediated toxicity. Primary neuronal cultures were prepared from rat embryonic (E14-E15) ventral mesencephalic tissue. Cultures treated with 2mM MA exhibited decreased tyrosine hydroxylase (TH) immunoreactivity and increased cleaved caspase-3 immunoreactivity and TUNEL labeling. All these changes were lessened by pretreatment with AP(4)A. The protective effect of AP(4)A was also found in vivo. Adult Sprague-Dawley rats were injected with AP(4)A (25 microg/20 microl) or vehicle intracerebroventricularly followed by 4 doses of MA (5 or 10 mg/kg), given subcutaneously every 2h. Administration of MA reduced locomotor activity 1 day after injection, which was significantly antagonized by the pretreatment with AP(4)A. Using immunohistochemical analysis, TH fiber density at the substantia nigra pars reticulata was found reduced while cleaved caspase-3 immunoreactivity in striatum was increased after MA treatment; these responses were also significantly antagonized by AP(4)A. Taken together, our data show that AP(4)A has protective effects against MA-mediated toxicity both in vitro and in vivo. The mechanism of action involves suppression of MA-induced apoptosis. JF - Neurotoxicology AU - Harvey, Brandon K AU - Chou, Jenny AU - Shen, Hui AU - Hoffer, Barry J AU - Wang, Yun AD - National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, United States. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 436 EP - 444 VL - 30 IS - 3 KW - Dinucleoside Phosphates KW - 0 KW - Neuroprotective Agents KW - Methamphetamine KW - 44RAL3456C KW - diadenosine tetraphosphate KW - 5542-28-9 KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Caspase 3 KW - EC 3.4.22.- KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Tyrosine 3-Monooxygenase -- metabolism KW - Drug Interactions KW - Corpus Striatum -- metabolism KW - Cell Culture Techniques KW - Dopamine -- metabolism KW - Mesencephalon -- cytology KW - Pregnancy KW - Rats KW - Rats, Sprague-Dawley KW - Corpus Striatum -- drug effects KW - Motor Activity -- drug effects KW - Female KW - Male KW - Caspase 3 -- metabolism KW - Methamphetamine -- administration & dosage KW - Neurons -- metabolism KW - Neuroprotective Agents -- administration & dosage KW - Neurons -- drug effects KW - Dinucleoside Phosphates -- administration & dosage KW - Methamphetamine -- antagonists & inhibitors KW - Dinucleoside Phosphates -- pharmacology KW - Neuroprotective Agents -- pharmacology KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67245286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Diadenosine+tetraphosphate+reduces+toxicity+caused+by+high-dose+methamphetamine+administration.&rft.au=Harvey%2C+Brandon+K%3BChou%2C+Jenny%3BShen%2C+Hui%3BHoffer%2C+Barry+J%3BWang%2C+Yun&rft.aulast=Harvey&rft.aufirst=Brandon&rft.date=2009-05-01&rft.volume=30&rft.issue=3&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=1872-9711&rft_id=info:doi/10.1016%2Fj.neuro.2009.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-04 N1 - Date created - 2009-05-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Acta Neurochir Suppl. 2008;101:93-8 [18642641] Neurosci Lett. 2001 Aug 31;309(3):177-80 [11514070] Neuroscience. 2008 Jan 2;151(1):92-103 [18082966] Brain Res Mol Brain Res. 2001 Sep 10;93(1):64-9 [11532339] Pflugers Arch. 2002 Jan;443(3):432-6 [11810214] Neuropharmacology. 2002 May;42(6):837-45 [12015210] Biochim Biophys Acta. 2003 Jan 2;1619(1):39-52 [12495814] J Neurosci. 2003 Aug 27;23(21):7958-65 [12944527] FASEB J. 2003 Oct;17(13):1775-88 [14519657] FASEB J. 2004 Feb;18(2):238-51 [14769818] Cell. 1984 May;37(1):225-32 [6373012] J Pharmacol Exp Ther. 1992 Feb;260(2):817-24 [1346646] Neurosci Lett. 1993 Feb 5;150(1):13-6 [8469395] J Pharmacol Exp Ther. 1994 Mar;268(3):1571-80 [8138969] J Neurochem. 1995 Feb;64(2):670-6 [7830059] Br J Pharmacol. 1995 Jul;115(6):895-902 [7582517] Psychopharmacology (Berl). 1996 Jul;126(1):55-61 [8853217] Synapse. 1996 Aug;23(4):280-91 [8855513] Ann N Y Acad Sci. 1996 Oct 31;801:187-98 [8959033] Synapse. 1997 Feb;25(2):176-84 [9021898] Brain Res. 1997 Jun 6;759(1):135-40 [9219871] J Neurosci. 1998 Mar 15;18(6):2009-16 [9482788] FEBS Lett. 1998 May 8;427(2):157-63 [9607303] Braz J Med Biol Res. 1998 Dec;31(12):1529-32 [9951547] FASEB J. 1999 Jun;13(9):1065-72 [10336889] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):868-73 [15644446] Neurotoxicology. 2006 Jan;27(1):131-6 [16165214] Neurotox Res. 2007 Apr;11(3-4):183-202 [17449459] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuro.2009.02.003 ER - TY - JOUR T1 - Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts. AN - 67228970; 19424414 AB - The p53 tumor suppressor regulates its target genes through sequence-specific binding to DNA response elements (REs). Although numerous p53 REs are established, the thousands more identified by bioinformatics are not easily subjected to comparative functional evaluation. To examine the relationship between RE sequence variation -- including polymorphisms -- and p53 binding, we have developed a multiplex format microsphere assay of protein-DNA binding (MAPD) for p53 in nuclear extracts. Using MAPD we measured sequence-specific p53 binding of doxorubicin-activated or transiently expressed p53 to REs from established p53 target genes and p53 consensus REs. To assess the sensitivity and scalability of the assay, we tested 16 variants of the p21 target sequence and a 62-multiplex set of single nucleotide (nt) variants of the p53 consensus sequence and found many changes in p53 binding that are not captured by current computational binding models. A group of eight single nucleotide polymorphisms (SNPs) was examined and binding profiles closely matched transactivation capability tested in luciferase constructs. The in vitro binding characteristics of p53 in nuclear extracts recapitulated the cellular in vivo transactivation capabilities for eight well-established human REs measured by luciferase assay. Using a set of 26 bona fide REs, we observed distinct binding patterns characteristic of transiently expressed wild type and mutant p53s. This microsphere assay system utilizes biologically meaningful cell extracts in a multiplexed, quantitative, in vitro format that provides a powerful experimental tool for elucidating the functional impact of sequence polymorphism and protein variation on protein/DNA binding in transcriptional networks. JF - PLoS genetics AU - Noureddine, Maher A AU - Menendez, Daniel AU - Campbell, Michelle R AU - Bandele, Omari J AU - Horvath, Monica M AU - Wang, Xuting AU - Pittman, Gary S AU - Chorley, Brian N AU - Resnick, Michael A AU - Bell, Douglas A AD - Environmental Genomics Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1 VL - 5 IS - 5 KW - Fluorescent Dyes KW - 0 KW - Recombinant Proteins KW - TP53 protein, human KW - Tumor Suppressor Protein p53 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Sensitivity and Specificity KW - Polymorphism, Single Nucleotide KW - Cell Nucleus -- metabolism KW - Humans KW - Gene Regulatory Networks KW - Recombinant Proteins -- genetics KW - Protein Binding KW - Microspheres KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Genes, p53 KW - Recombinant Proteins -- metabolism KW - Models, Genetic KW - In Vitro Techniques KW - Recombinant Proteins -- chemistry KW - Binding Sites -- genetics KW - DNA -- metabolism KW - DNA -- genetics KW - Tumor Suppressor Protein p53 -- chemistry KW - Tumor Suppressor Protein p53 -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Genetic Techniques -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67228970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+genetics&rft.atitle=Probing+the+functional+impact+of+sequence+variation+on+p53-DNA+interactions+using+a+novel+microsphere+assay+for+protein-DNA+binding+with+human+cell+extracts.&rft.au=Noureddine%2C+Maher+A%3BMenendez%2C+Daniel%3BCampbell%2C+Michelle+R%3BBandele%2C+Omari+J%3BHorvath%2C+Monica+M%3BWang%2C+Xuting%3BPittman%2C+Gary+S%3BChorley%2C+Brian+N%3BResnick%2C+Michael+A%3BBell%2C+Douglas+A&rft.aulast=Noureddine&rft.aufirst=Maher&rft.date=2009-05-01&rft.volume=5&rft.issue=5&rft.spage=e1000462&rft.isbn=&rft.btitle=&rft.title=PLoS+genetics&rft.issn=1553-7404&rft_id=info:doi/10.1371%2Fjournal.pgen.1000462 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-13 N1 - Date created - 2009-05-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2003 Oct;12(4):1015-27 [14580351] Cancer Res. 2008 Dec 1;68(23):9671-7 [19047144] Science. 1992 May 8;256(5058):827-30 [1589764] Nat Genet. 1992 Apr;1(1):45-9 [1301998] Mol Cell Biol. 1995 Apr;15(4):2157-65 [7891710] BMC Genomics. 2005;6:18 [15717931] J Mol Biol. 2005 May 6;348(3):589-96 [15826656] Proc Natl Acad Sci U S A. 2005 May 3;102(18):6431-6 [15843459] Fertil Steril. 2005 Aug;84(2):446-53 [16084888] Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):84-90 [16002116] Gene. 2005 Oct 10;359:44-52 [16102917] Cell. 2006 Jan 13;124(1):207-19 [16413492] Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1406-11 [16432214] J Clin Microbiol. 2006 Feb;44(2):504-12 [16455905] Mol Cell Biol. 2006 Mar;26(6):2297-308 [16508005] Cytometry A. 2006 May;69(5):374-83 [16604539] Cancer Res. 2006 May 15;66(10):5104-10 [16707433] Methods Mol Biol. 2006;338:245-60 [16888363] Mol Cell Biol. 2006 Sep;26(18):6859-69 [16943427] EMBO J. 2006 Oct 18;25(20):4820-32 [16990795] J Immunol Methods. 2006 Oct 20;316(1-2):97-106 [17010371] Nat Biotechnol. 2006 Nov;24(11):1429-35 [16998473] Nucleic Acids Res. 2007;35(1):340-52 [17170001] Hum Genet. 2007 Feb;120(6):879-88 [17006670] Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L448-53 [17071721] Oncogene. 2007 Apr 2;26(15):2157-65 [17401424] Oncogene. 2007 Apr 2;26(15):2191-201 [17401428] Hum Mutat. 2007 Jun;28(6):622-9 [17311302] Hum Mol Genet. 2007 May 15;16(10):1188-200 [17409198] PLoS Genet. 2007 Jul;3(7):e127 [17677004] Nat Genet. 2007 Oct;39(10):1217-24 [17873874] Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):944-9 [18187580] Nucleic Acids Res. 2008 Mar;36(5):1589-98 [18234719] Nat Rev Mol Cell Biol. 2008 May;9(5):402-12 [18431400] Oncogene. 2008 Jul 3;27(29):4013-23 [18278067] PLoS One. 2008;3(7):e2535 [18596971] Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11936-41 [11035798] Biochem Biophys Res Commun. 2001 Jun 22;284(4):880-6 [11409876] Cytometry. 2001 Aug 1;44(4):326-37 [11500849] Mol Cell. 2001 Jul;8(1):57-69 [11511360] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):95-100 [11756653] Mol Biol Evol. 2002 Jul;19(7):1114-21 [12082130] Biotechniques. 2002 Jun;Suppl:56-8, 60-1 [12083399] Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8467-72 [12077306] Exp Hematol. 2002 Nov;30(11):1227-37 [12423675] Mol Cell Biol. 2002 Dec;22(24):8612-25 [12446780] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9934-9 [12909720] Methods Mol Biol. 2003;226:123-34 [12958493] J Biol Chem. 2003 Sep 26;278(39):37536-44 [12860987] PLoS Genet. 2008 Jun;4(6):e1000104 [18714371] Science. 2008 Oct 17;322(5900):434-8 [18787134] J Biotechnol. 2004 Mar 18;108(3):193-205 [15006421] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pgen.1000462 ER - TY - JOUR T1 - Common variation in genes related to innate immunity and risk of adult glioma. AN - 67227585; 19423540 AB - Current evidence suggests that immune system alterations contribute to the etiology of adult glioma, the most common adult brain tumor. Although previous studies have focused on variation in candidate genes in the adaptive immune system, the innate immune system has emerged as a critical avenue for research given its known link with carcinogenesis. To identify genetic markers in pathways critical to innate immunity, we conducted an association study of 551 glioma cases and 865 matched controls of European ancestry to investigate "tag" single nucleotide polymorphisms (SNP) in 148 genetic regions. Two independent U.S. case-control studies included were as follows: a hospital-based study conducted by the National Cancer Institute (263 cases, 330 controls) and a community-based study conducted by the National Institute for Occupational Safety and Health (288 cases, 535 controls). Tag SNPs (1,397) chosen on the basis of an r(2) of >0.8 and minor allele frequency of >5% in Caucasians in HapMap1 were genotyped. Glioma risk was estimated by odds ratios. Nine SNPs distributed across eight genetic regions (ALOX5, IRAK3, ITGB2, NCF2, NFKB1, SELP, SOD1, and STAT1) were associated with risk of glioma with P value of <0.01. Although these associations were no longer statistically significant after controlling for multiple comparisons, the associations were notably consistent in both studies. Region-based tests were statistically significant (P < 0.05) for SELP, SOD, and ALOX5. Analyses restricted to glioblastoma (n = 254) yielded significant associations for the SELP, DEFB126/127, SERPINI1, and LY96 genetic regions. We have identified a promising set of innate immunity-related genetic regions for further investigation. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Rajaraman, Preetha AU - Brenner, Alina V AU - Butler, Mary Ann AU - Wang, Sophia S AU - Pfeiffer, Ruth M AU - Ruder, Avima M AU - Linet, Martha S AU - Yeager, Meredith AU - Wang, Zhaoming AU - Orr, Nick AU - Fine, Howard A AU - Kwon, Deukwoo AU - Thomas, Gilles AU - Rothman, Nathaniel AU - Inskip, Peter D AU - Chanock, Stephen J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA. rajarama@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1651 EP - 1658 VL - 18 IS - 5 SN - 1055-9965, 1055-9965 KW - 5-Lipoxygenase-Activating Proteins KW - 0 KW - ALOX5AP protein, human KW - Carrier Proteins KW - Cytoskeletal Proteins KW - DEFB126 protein, human KW - Epididymal Secretory Proteins KW - ITGB1BP2 protein, human KW - LY96 protein, human KW - Lymphocyte Antigen 96 KW - Membrane Proteins KW - Muscle Proteins KW - NF-kappa B p50 Subunit KW - NFKB1 protein, human KW - Neuropeptides KW - SOD1 protein, human KW - STAT1 Transcription Factor KW - STAT1 protein, human KW - Selenoprotein P KW - Serpins KW - beta-Defensins KW - neuroserpin KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Superoxide Dismutase-1 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - NCF2 protein, human KW - IRAK3 protein, human KW - EC 2.7.11.1 KW - Interleukin-1 Receptor-Associated Kinases KW - Index Medicus KW - United States KW - Genetic Variation KW - Polymorphism, Single Nucleotide KW - Epididymal Secretory Proteins -- genetics KW - Carrier Proteins -- genetics KW - Humans KW - Aged KW - Membrane Proteins -- genetics KW - Alleles KW - NF-kappa B p50 Subunit -- genetics KW - Aged, 80 and over KW - European Continental Ancestry Group KW - Adult KW - Adolescent KW - Serpins -- genetics KW - Interleukin-1 Receptor-Associated Kinases -- genetics KW - Lymphocyte Antigen 96 -- genetics KW - Male KW - Cytoskeletal Proteins -- genetics KW - Glioblastoma -- genetics KW - STAT1 Transcription Factor -- genetics KW - Selenoprotein P -- genetics KW - Glioblastoma -- immunology KW - Genotype KW - Muscle Proteins -- genetics KW - Risk KW - Logistic Models KW - Case-Control Studies KW - Superoxide Dismutase -- genetics KW - Middle Aged KW - NADPH Oxidase -- genetics KW - Female KW - Neuropeptides -- genetics KW - Glioma -- immunology KW - Glioma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67227585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Common+variation+in+genes+related+to+innate+immunity+and+risk+of+adult+glioma.&rft.au=Rajaraman%2C+Preetha%3BBrenner%2C+Alina+V%3BButler%2C+Mary+Ann%3BWang%2C+Sophia+S%3BPfeiffer%2C+Ruth+M%3BRuder%2C+Avima+M%3BLinet%2C+Martha+S%3BYeager%2C+Meredith%3BWang%2C+Zhaoming%3BOrr%2C+Nick%3BFine%2C+Howard+A%3BKwon%2C+Deukwoo%3BThomas%2C+Gilles%3BRothman%2C+Nathaniel%3BInskip%2C+Peter+D%3BChanock%2C+Stephen+J&rft.aulast=Rajaraman&rft.aufirst=Preetha&rft.date=2009-05-01&rft.volume=18&rft.issue=5&rft.spage=1651&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-1041 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-25 N1 - Date created - 2009-05-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Immunol. 2007 Mar;28(3):138-45 [17276138] Free Radic Biol Med. 2008 Dec 1;45(11):1501-9 [18790046] Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1229-35 [17548690] Nature. 2007 Jun 7;447(7145):655-60 [17554299] J Natl Cancer Inst. 2007 Oct 17;99(20):1544-50 [17925535] J Mol Med (Berl). 2007 Nov;85(11):1271-80 [17634906] N Engl J Med. 2001 Jan 11;344(2):79-86 [11150357] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Int J Cancer. 2002 Apr 1;98(4):609-15 [11920623] Int J Cancer. 2002 May 10;99(2):252-9 [11979441] Hum Mutat. 2002 Jul;20(1):1-14 [12112652] Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Jun;3(2):69-74 [12215228] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Int J Cancer. 2003 Sep 1;106(3):423-8 [12845684] Genet Epidemiol. 2003 Dec;25(4):360-6 [14639705] Nature. 2003 Dec 18;426(6968):789-96 [14685227] J Med Genet. 2004 May;41(5):334-41 [15121769] Clin Chem. 1985 Jan;31(1):164-5 [3965205] Cancer. 1992 May 15;69(10):2541-7 [1568177] Epidemiology. 1993 Jul;4(4):295-302 [8347739] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Methods Enzymol. 1996;272:199-210 [8791778] Int J Cancer. 1999 Jul 19;82(2):155-60 [10389745] Cancer Res. 2004 Nov 15;64(22):8468-73 [15548720] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Cancer Res. 2005 Jul 15;65(14):6459-65 [16024651] Nat Rev Immunol. 2005 Nov;5(11):866-79 [16261174] Cell Mol Life Sci. 2006 Mar;63(6):709-22 [16465451] Cancer Res. 2006 Apr 15;66(8):4531-41 [16618782] Nat Genet. 2006 Aug;38(8):904-9 [16862161] Int J Cancer. 2006 Nov 1;119(9):2165-72 [16823851] Immunol Rev. 2006 Oct;213:48-65 [16972896] Immunol Rev. 2006 Oct;213:195-212 [16972905] J Agric Saf Health. 2006 Nov;12(4):255-74 [17131948] Trends Immunol. 2007 Jan;28(1):12-8 [17129764] J Clin Neurosci. 2007 Nov;14(11):1041-8 [17954373] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2448-54 [18006935] Carcinogenesis. 2007 Dec;28(12):2543-7 [17916900] Genet Epidemiol. 2007 Dec;31(8):803-12 [17549762] Arthritis Rheum. 2007 Dec;56(12):4164-73 [18050247] Amyotroph Lateral Scler. 2008 Apr;9(2):108-19 [18428003] PLoS One. 2008;3(7):e2551 [18596976] J Am Coll Cardiol. 2007 May 15;49(19):1934-42 [17498578] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-1041 ER - TY - JOUR T1 - Improving mental health treatments through comparative effectiveness research. AN - 67216405; 19414887 AB - There is a pressing need for comparative effectiveness research to improve mental health treatments. Although U.S. mental health spending has increased dramatically, mainly because of the rapid adoption of newer psychotropic medications, fewer than a quarter of people with serious mental illnesses receive appropriate care. Because of a general lack of information on the relative effectiveness of different treatments, payers are uncertain about the value of current spending, which in turn may deter new investments to reduce unmet need. We use several recent comparative effectiveness trials to illustrate the potential value of such research for improving practice and policy. JF - Health affairs (Project Hope) AU - Wang, Philip S AU - Ulbricht, Christine M AU - Schoenbaum, Michael AD - National Institute of Mental Health (NIMH) in Bethesda, Maryland, USA. wangphi@mail.nih.gov PY - 2009 SP - 783 EP - 791 VL - 28 IS - 3 KW - Antidepressive Agents KW - 0 KW - Antipsychotic Agents KW - Psychotropic Drugs KW - Index Medicus KW - United States KW - Humans KW - Alzheimer Disease -- drug therapy KW - Antipsychotic Agents -- therapeutic use KW - Antidepressive Agents -- adverse effects KW - Insurance Coverage KW - Drug Costs -- statistics & numerical data KW - Psychotic Disorders -- economics KW - Alzheimer Disease -- economics KW - Depressive Disorder, Major -- drug therapy KW - Cost-Benefit Analysis KW - Treatment Outcome KW - Antipsychotic Agents -- economics KW - Antidepressive Agents -- therapeutic use KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Depressive Disorder, Major -- economics KW - Schizophrenia -- economics KW - Insurance, Pharmaceutical Services KW - Antidepressive Agents -- economics KW - Psychotic Disorders -- drug therapy KW - Randomized Controlled Trials as Topic KW - Mental Disorders -- drug therapy KW - Psychotropic Drugs -- economics KW - Psychotropic Drugs -- therapeutic use KW - Evidence-Based Medicine -- economics KW - Health Policy -- economics KW - Mental Disorders -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67216405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+affairs+%28Project+Hope%29&rft.atitle=Improving+mental+health+treatments+through+comparative+effectiveness+research.&rft.au=Wang%2C+Philip+S%3BUlbricht%2C+Christine+M%3BSchoenbaum%2C+Michael&rft.aulast=Wang&rft.aufirst=Philip&rft.date=2009-05-01&rft.volume=28&rft.issue=3&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Health+affairs+%28Project+Hope%29&rft.issn=1544-5208&rft_id=info:doi/10.1377%2Fhlthaff.28.3.783 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-03 N1 - Date created - 2009-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1377/hlthaff.28.3.783 ER - TY - JOUR T1 - A study of Amplicor human papillomavirus DNA detection in the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study. AN - 67213402; 19423515 AB - We analyzed the performance of Amplicor for detecting carcinogenic human papillomavirus (HPV) infections and cervical precancer in women with an atypical squamous cells of undetermined significance (ASCUS) Pap and compared the results with Hybrid Capture 2 (hc2) in the ASCUS and low-grade squamous intraepithelial lesion (LSIL) triage study (ALTS). Baseline specimens collected from women referred into ALTS based on an ASCUS Pap result were prospectively tested by hc2 and retrospectively tested by Amplicor (n = 3,277). Following receiver-operator-characteristics curve analysis, Amplicor performance was analyzed at three cutoffs (0.2, 1.0, and 1.5). Paired Amplicor and hc2 results were compared for the detection of 2-year cumulative cervical intraepithelial neoplasia (CIN) grade 3 and more severe disease outcomes (CIN3+) and for the detection of 13 targeted carcinogenic HPV types. Amplicor at the 0.2 cutoff had a higher sensitivity for the detection of CIN3+ (95.8% versus 92.6%, P = 0.01) but a much lower specificity (38.9% versus 50.6%, P < 0.001) than hc2. Amplicor at the 1.5 cutoff had an identical sensitivity for the detection of CIN3+ (92.6%) and a slightly lower specificity (47.5%; P < 0.001). The positive predictive value of hc2 was higher at all Amplicor cutoffs, whereas referral rates were significantly lower (53.2% for hc2 versus 64.1% at the 0.2 cutoff and 56.0% at the 1.5 cutoff, P < 0.001). Amplicor was more analytically specific for detecting targeted carcinogenic HPV types than hc2. Amplicor at the 1.5 cutoff had comparable performance with hc2. Whereas Amplicor missed more disease related to nontargeted types, hc2 was more likely to miss disease related to targeted types. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Wentzensen, Nicolas AU - Gravitt, Patti E AU - Solomon, Diane AU - Wheeler, Cosette M AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20854-7234, USA. wentzenn@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1341 EP - 1349 VL - 18 IS - 5 SN - 1055-9965, 1055-9965 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Prospective Studies KW - ROC Curve KW - Triage KW - Risk Factors KW - Humans KW - Chi-Square Distribution KW - Adult KW - Retrospective Studies KW - Vaginal Smears KW - Predictive Value of Tests KW - Female KW - Cervical Intraepithelial Neoplasia -- pathology KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics KW - Papillomavirus Infections -- genetics KW - Molecular Diagnostic Techniques -- methods KW - Precancerous Conditions -- virology KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- genetics KW - Cervical Intraepithelial Neoplasia -- genetics KW - Papillomaviridae -- classification KW - DNA, Viral -- analysis KW - Cervical Intraepithelial Neoplasia -- virology KW - DNA, Viral -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67213402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=A+study+of+Amplicor+human+papillomavirus+DNA+detection+in+the+atypical+squamous+cells+of+undetermined+significance-low-grade+squamous+intraepithelial+lesion+triage+study.&rft.au=Wentzensen%2C+Nicolas%3BGravitt%2C+Patti+E%3BSolomon%2C+Diane%3BWheeler%2C+Cosette+M%3BCastle%2C+Philip+E&rft.aulast=Wentzensen&rft.aufirst=Nicolas&rft.date=2009-05-01&rft.volume=18&rft.issue=5&rft.spage=1341&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-1180 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-25 N1 - Date created - 2009-05-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] Acta Cytol. 2000 Sep-Oct;44(5):726-42 [11015972] J Natl Cancer Inst. 2001 Feb 21;93(4):293-9 [11181776] J Infect Dis. 2001 Jun 1;183(11):1554-64 [11343204] Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):477-84 [12814990] Am J Obstet Gynecol. 2003 Jun;188(6):1383-92 [12824967] Am J Obstet Gynecol. 2003 Jun;188(6):1393-400 [12824968] Am J Clin Pathol. 2004 Aug;122(2):238-45 [15323141] J Clin Virol. 2004 Oct;31(2):140-7 [15364271] Obstet Gynecol. 1998 Jun;91(6):973-6 [9611007] Biometrics. 1998 Jun;54(2):444-52 [9629638] Lancet Oncol. 2005 Apr;6(4):204 [15830458] J Clin Microbiol. 2005 Jun;43(6):2662-7 [15956381] Gynecol Oncol. 2005 Oct;99(1):160-8 [16023184] Am J Clin Pathol. 2005 Nov;124(5):722-32 [16203281] Am J Clin Pathol. 2005 Nov;124(5):716-21 [16203283] J Natl Cancer Inst. 2006 Jan 18;98(2):92-100 [16418511] Int J Cancer. 2006 Sep 1;119(5):1095-101 [16586444] Vaccine. 2006 Aug 31;24 Suppl 3:S3/78-89 [16950021] Cancer Res. 2006 Oct 15;66(20):10112-9 [17047075] J Clin Microbiol. 2007 Feb;45(2):364-9 [17122008] J Clin Microbiol. 2007 May;45(5):1447-54 [17344361] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Cancer. 2007 Jun 25;111(3):145-53 [17487850] J Med Virol. 2007 Aug;79(8):1169-75 [17596834] J Clin Microbiol. 2007 Jul;45(7):2130-7 [17494721] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] J Low Genit Tract Dis. 2007 Oct;11(4):201-22 [17917566] N Engl J Med. 2007 Oct 18;357(16):1579-88 [17942871] N Engl J Med. 2007 Oct 18;357(16):1589-97 [17942872] Lancet. 2007 Nov 24;370(9601):1764-72 [17919718] Cancer Res. 2008 Jan 1;68(1):307-13 [18172324] J Clin Microbiol. 2008 Jan;46(1):109-17 [17989194] J Clin Virol. 2008 Feb;41(2):104-10 [18036888] J Natl Cancer Inst. 2008 Mar 5;100(5):308-20 [18314477] Int J Cancer. 2008 Jul 1;123(1):153-60 [18404671] Lancet Oncol. 2008 May;9(5):425-34 [18407790] Lancet Oncol. 2008 May;9(5):404-6 [18452848] J Clin Microbiol. 2008 Aug;46(8):2595-604 [18579716] Vaccine. 2008 Aug 19;26 Suppl 10:K42-52 [18847556] Erratum In: Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1943 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-1180 ER - TY - JOUR T1 - Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions. AN - 67213348; 19363293 AB - The uptake of lipoproteins by macrophages is a critical step in the development of atherosclerotic lesions. Cultured monocyte-derived macrophages take up large amounts of native LDL by receptor-independent fluid-phase pinocytosis, either constitutively or in response to specific activating stimuli, depending on the macrophage phenotype. We therefore sought to determine whether fluid-phase pinocytosis occurs in vivo in macrophages in atherosclerotic lesions. We demonstrated that fluorescent pegylated nanoparticles similar in size to LDL (specifically nontargeted Qtracker quantum dot and AngioSPARK nanoparticles) can serve as models of LDL uptake by fluid-phase pinocytosis in cultured human monocyte-derived macrophages and mouse bone marrow-derived macrophages. Using fluorescence microscopy, we showed that atherosclerosis-prone Apoe-knockout mice injected with these nanoparticles displayed massive accumulation of the nanoparticles within CD68+ macrophages, including lipid-containing foam cells, in atherosclerotic lesions in the aortic arch. Similar results were obtained when atherosclerotic mouse aortas were cultured with nanoparticles in vitro. These results show that macrophages within atherosclerotic lesions can take up LDL-sized nanoparticles by fluid-phase pinocytosis and indicate that fluid-phase pinocytosis of LDL is a mechanism for macrophage foam cell formation in vivo. JF - The Journal of clinical investigation AU - Buono, Chiara AU - Anzinger, Joshua J AU - Amar, Marcelo AU - Kruth, Howard S AD - Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland 20892-1422, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1373 EP - 1381 VL - 119 IS - 5 KW - Apolipoproteins E KW - 0 KW - Cholesterol, Dietary KW - Fluorescent Dyes KW - Lipoproteins, LDL KW - acetyl-LDL KW - Cytochalasin D KW - 22144-77-0 KW - Polyethylene Glycols KW - 30IQX730WE KW - Abridged Index Medicus KW - Index Medicus KW - Aorta -- metabolism KW - Foam Cells -- physiology KW - Animals KW - Quantum Dots KW - Particle Size KW - Humans KW - Aorta, Thoracic -- metabolism KW - Aorta -- pathology KW - Mice KW - Mice, Knockout KW - Foam Cells -- cytology KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Lipoproteins, LDL -- metabolism KW - Cytochalasin D -- pharmacology KW - Cholesterol, Dietary -- pharmacology KW - Aorta, Thoracic -- pathology KW - Female KW - Apolipoproteins E -- genetics KW - Macrophages -- cytology KW - Atherosclerosis -- pathology KW - Polyethylene Glycols -- chemistry KW - Fluorescent Dyes -- chemistry KW - Pinocytosis -- drug effects KW - Macrophages -- drug effects KW - Atherosclerosis -- chemically induced KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67213348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Fluorescent+pegylated+nanoparticles+demonstrate+fluid-phase+pinocytosis+by+macrophages+in+mouse+atherosclerotic+lesions.&rft.au=Buono%2C+Chiara%3BAnzinger%2C+Joshua+J%3BAmar%2C+Marcelo%3BKruth%2C+Howard+S&rft.aulast=Buono&rft.aufirst=Chiara&rft.date=2009-05-01&rft.volume=119&rft.issue=5&rft.spage=1373&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=1558-8238&rft_id=info:doi/10.1172%2FJCI35548 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-08 N1 - Date created - 2009-05-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Med Microbiol. 2002 Feb;291(6-7):487-94 [11890548] Am J Pathol. 2008 Apr;172(4):1112-26 [18321997] J Clin Invest. 2002 Oct;110(7):905-11 [12370266] J Biol Chem. 2002 Dec 20;277(51):49982-8 [12376530] Ann Intern Med. 1979 Jan;90(1):85-91 [217290] Biochem Biophys Res Commun. 1978 Dec 29;85(4):1424-30 [217387] Proc Natl Acad Sci U S A. 1979 Jan;76(1):333-7 [218198] J Supramol Struct. 1980;13(1):67-81 [6255257] J Biol Chem. 1982 Jan 10;257(1):307-10 [6273431] J Cell Biol. 1982 Apr;93(1):49-56 [6279673] Biochim Biophys Acta. 1982 Aug 18;712(2):412-9 [7126615] Arteriosclerosis. 1983 Jan-Feb;3(1):2-12 [6297442] Biochim Biophys Acta. 1983 Dec 20;754(3):249-57 [6197091] Atherosclerosis. 1984 May-Jun;51(2-3):281-92 [6204652] Am J Pathol. 1985 Nov;121(2):200-11 [3840653] Mech Ageing Dev. 1986 Feb;33(3):305-12 [3713267] J Lipid Res. 1987 Jan;28(1):32-41 [3559399] Eur Heart J. 1990 Aug;11 Suppl E:72-81 [2226536] Am J Pathol. 1992 Feb;140(2):291-300 [1739123] Am J Pathol. 1992 Feb;140(2):301-16 [1739124] Cell. 1992 Oct 16;71(2):343-53 [1423598] J Lipid Res. 1993 Feb;34(2):325-30 [8381454] Blood. 1997 Jan 1;89(1):315-21 [8978307] Circulation. 1997 Feb 18;95(4):1062-71 [9054771] J Biol Chem. 1951 Nov;193(1):265-75 [14907713] J Biol Chem. 2005 Jan 21;280(3):2352-60 [15533943] N Engl J Med. 2005 Apr 21;352(16):1685-95 [15843671] J Clin Invest. 2005 Aug;115(8):2192-201 [16075060] Micron. 2006;37(3):208-22 [16360317] Immunology. 2006 Apr;117(4):443-51 [16556257] J Biol Chem. 2006 Jun 9;281(23):15757-62 [16606620] Biochem Biophys Res Commun. 2006 Oct 13;349(1):214-20 [16930534] J Lipid Res. 2007 Aug;48(8):1710-23 [17476031] Environ Health Perspect. 2007 Sep;115(9):1339-43 [17805425] J Lipid Res. 2007 Nov;48(11):2411-8 [17693624] Lancet. 2007 Dec 1;370(9602):1829-39 [18061058] Cardiovasc Res. 2008 Apr 1;78(1):185-96 [18065445] J Biol Chem. 2002 Sep 13;277(37):34573-80 [12118008] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1172/JCI35548 ER - TY - JOUR T1 - Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer. AN - 67204406; 19401522 JF - Cancer prevention research (Philadelphia, Pa.) AU - Vitale-Cross, Lynn AU - Czerninski, Rakefet AU - Amornphimoltham, Panomwat AU - Patel, Vyomesh AU - Molinolo, Alfredo A AU - Gutkind, J Silvio AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research/NIH, 30 Convent Drive, Bethesda, MD 20892-4340, USA. sg39v@nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 419 EP - 422 VL - 2 IS - 5 KW - Index Medicus KW - Animals KW - Humans KW - Mouth Neoplasms -- prevention & control KW - Carcinoma, Squamous Cell -- prevention & control KW - Carcinoma, Squamous Cell -- genetics KW - Models, Biological KW - Mouth Neoplasms -- genetics KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67204406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Chemical+carcinogenesis+models+for+evaluating+molecular-targeted+prevention+and+treatment+of+oral+cancer.&rft.au=Vitale-Cross%2C+Lynn%3BCzerninski%2C+Rakefet%3BAmornphimoltham%2C+Panomwat%3BPatel%2C+Vyomesh%3BMolinolo%2C+Alfredo+A%3BGutkind%2C+J+Silvio&rft.aulast=Vitale-Cross&rft.aufirst=Lynn&rft.date=2009-05-01&rft.volume=2&rft.issue=5&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-09-0058 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-09-0058 ER - TY - JOUR T1 - Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. AN - 67200135; 19255064 AB - We systematically investigated the association of 48 SNPS in four vitamin D metabolizing genes [CYP27A1, GC, CYP27B1 and CYP24A1] with serum 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] levels and the association of these SNPS and an additional 164 SNPS in eight downstream mediators of vitamin D signaling [VDR, RXRA, RXRB, PPAR, NCOA1, NCOA2, NCOA3 and SMAD3] with prostate cancer risk in the 749 incident prostate cancer cases and 781 controls of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. 25(OH)D (all cases and controls) and 1,25(OH)(2)D (a subset of 150 controls) levels were measured by radioimmunoassay and SNP data were genotyped as part of a genome-wide scan. Among investigated SNPS, only four tag SNPS in GC, the major serum 25(OH)D carrier, were associated with 25(OH)D levels; no SNPS were associated with 1,25(OH)(2)D levels. None of the 212 SNPS examined were associated with cancer risk overall. Among men in the lowest tertile of serum 25(OH)D (<48.9 nmol/l), however, prostate cancer risk was related to tag SNPS in or near the 3' untranslated region (UTR) of VDR, with the strongest association for rs11574143 [odds ratio (95% confidence interval) for risk allele carriers versus wild-type: 2.49 (1.51-4.11), P = 0.0007]; the genotype associations were null among men in tertile 2 and tertile 3. Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status. JF - Carcinogenesis AU - Ahn, Jiyoung AU - Albanes, Demetrius AU - Berndt, Sonja I AU - Peters, Ulrike AU - Chatterjee, Nilanjan AU - Freedman, Neal D AU - Abnet, Christian C AU - Huang, Wen-Yi AU - Kibel, Adam S AU - Crawford, E David AU - Weinstein, Stephanie J AU - Chanock, Stephen J AU - Schatzkin, Arthur AU - Hayes, Richard B AU - Prostate, Lung, Colorectal and Ovarian Trial Project Team AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA. ahnj@mail.nih.gov ; Prostate, Lung, Colorectal and Ovarian Trial Project Team Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 769 EP - 776 VL - 30 IS - 5 KW - Vitamin D KW - 1406-16-2 KW - Steroid Hydroxylases KW - EC 1.14.- KW - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase KW - EC 1.14.13.13 KW - CYP27A1 protein, human KW - EC 1.14.15.15 KW - Cholestanetriol 26-Monooxygenase KW - CYP24A1 protein, human KW - EC 1.14.15.16 KW - Vitamin D3 24-Hydroxylase KW - Calcitriol KW - FXC9231JVH KW - Calcifediol KW - P6YZ13C99Q KW - Index Medicus KW - Genotype KW - Genetic Variation KW - Polymorphism, Single Nucleotide KW - Risk Factors KW - Humans KW - Genetic Predisposition to Disease KW - United States -- epidemiology KW - Male KW - Risk Assessment KW - Genome-Wide Association Study KW - Cholestanetriol 26-Monooxygenase -- genetics KW - Calcifediol -- blood KW - Prostatic Neoplasms -- epidemiology KW - Vitamin D -- blood KW - Prostatic Neoplasms -- blood KW - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase -- genetics KW - Prostatic Neoplasms -- genetics KW - Steroid Hydroxylases -- genetics KW - Prostatic Neoplasms -- enzymology KW - Calcitriol -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67200135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Vitamin+D-related+genes%2C+serum+vitamin+D+concentrations+and+prostate+cancer+risk.&rft.au=Ahn%2C+Jiyoung%3BAlbanes%2C+Demetrius%3BBerndt%2C+Sonja+I%3BPeters%2C+Ulrike%3BChatterjee%2C+Nilanjan%3BFreedman%2C+Neal+D%3BAbnet%2C+Christian+C%3BHuang%2C+Wen-Yi%3BKibel%2C+Adam+S%3BCrawford%2C+E+David%3BWeinstein%2C+Stephanie+J%3BChanock%2C+Stephen+J%3BSchatzkin%2C+Arthur%3BHayes%2C+Richard+B%3BProstate%2C+Lung%2C+Colorectal+and+Ovarian+Trial+Project+Team&rft.aulast=Ahn&rft.aufirst=Jiyoung&rft.date=2009-05-01&rft.volume=30&rft.issue=5&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp055 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-20 N1 - Date created - 2009-05-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 1997 Sep 8;238(1):77-80 [9299455] J Bone Miner Res. 1997 Jun;12(6):915-21 [9169350] Nutr Rev. 1998 Feb;56(2 Pt 2):S4-10; discussion S 54-75 [9564171] Cancer Epidemiol Biomarkers Prev. 1998 May;7(5):385-90 [9610787] Cancer Epidemiol Biomarkers Prev. 1998 May;7(5):391-5 [9610788] Cancer Causes Control. 1998 Aug;9(4):425-32 [9794175] Genet Epidemiol. 2004 Dec;27(4):348-64 [15543638] Cancer Res. 2005 Jun 15;65(12):5470-9 [15958597] Mutat Res. 2005 Dec 30;592(1-2):147-54 [16054167] J Urol. 2006 May;175(5):1613-23 [16600714] Nat Genet. 2007 May;39(5):645-9 [17401363] Prostate. 2007 Jun 15;67(9):911-23 [17440943] PLoS Med. 2007 Mar;4(3):e103 [17388667] Nat Rev Cancer. 2007 Sep;7(9):684-700 [17721433] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):1990-9 [17932346] Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2784-6 [18086789] J Natl Cancer Inst. 2008 Jun 4;100(11):796-804 [18505967] Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):265-70 [10750664] Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684] J Clin Endocrinol Metab. 2001 Feb;86(2):888-94 [11158062] BJU Int. 2002 Oct;90(6):607-16 [12230626] Stat Med. 2003 May 15;22(9):1477-93 [12704611] Hum Hered. 2003;55(1):56-65 [12890927] Int J Cancer. 2004 Jan 1;108(1):104-8 [14618623] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Environ Mol Mutagen. 2004;43(2):121-7 [14991752] Cancer Causes Control. 2004 Apr;15(3):255-65 [15090720] J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):533-7 [15225833] Gene. 2004 Sep 1;338(2):143-56 [15315818] Diabetes. 2004 Oct;53(10):2709-12 [15448105] Cancer Res. 1992 Feb 1;52(3):515-20 [1370648] Nature. 1992 Aug 27;358(6389):771-4 [1324435] Cancer Epidemiol Biomarkers Prev. 1993 Sep-Oct;2(5):467-72 [8220092] Cancer Res. 1994 Feb 1;54(3):805-10 [7508338] Nature. 1994 Jan 20;367(6460):284-7 [8161378] Curr Opin Cell Biol. 1995 Jun;7(3):386-92 [7662369] Trends Biochem Sci. 1995 Nov;20(11):465-70 [8578590] Cancer Epidemiol Biomarkers Prev. 1996 Feb;5(2):121-6 [8850273] J Bone Miner Res. 1997 May;12(5):726-33 [9144338] Methods Enzymol. 1997;282:174-86 [9330287] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp055 ER - TY - JOUR T1 - Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. AN - 67197821; 19286953 AB - Doxorubicin (DOX) is a potent available antitumor agent; however, its clinical use is limited because of its cardiotoxicity. Cell death is a key component in DOX-induced cardiotoxicity, but its mechanisms are elusive. Here, we explore the role of superoxide, nitric oxide (NO), and peroxynitrite in DOX-induced cell death using both in vivo and in vitro models of cardiotoxicity. Western blot analysis, real-time PCR, immunohistochemistry, flow cytometry, fluorescent microscopy, and biochemical assays were used to determine the markers of apoptosis/necrosis and sources of NO and superoxide and their production. Left ventricular function was measured by a pressure-volume system. We demonstrated increases in myocardial apoptosis (caspase-3 cleavage/activity, cytochrome c release, and TUNEL), inducible NO synthase (iNOS) expression, mitochondrial superoxide generation, 3-nitrotyrosine (NT) formation, matrix metalloproteinase (MMP)-2/MMP-9 gene expression, poly(ADP-ribose) polymerase activation [without major changes in NAD(P)H oxidase isoform 1, NAD(P)H oxidase isoform 2, p22(phox), p40(phox), p47(phox), p67(phox), xanthine oxidase, endothelial NOS, and neuronal NOS expression] and decreases in myocardial contractility, catalase, and glutathione peroxidase activities 5 days after DOX treatment to mice. All these effects of DOX were markedly attenuated by peroxynitrite scavengers. Doxorubicin dose dependently increased mitochondrial superoxide and NT generation and apoptosis/necrosis in cardiac-derived H9c2 cells. DOX- or peroxynitrite-induced apoptosis/necrosis positively correlated with intracellular NT formation and could be abolished by peroxynitrite scavengers. DOX-induced cell death and NT formation were also attenuated by selective iNOS inhibitors or in iNOS knockout mice. Various NO donors when coadministered with DOX but not alone dramatically enhanced DOX-induced cell death with concomitant increased NT formation. DOX-induced cell death was also attenuated by cell-permeable SOD but not by cell-permeable catalase, the xanthine oxidase inhibitor allopurinol, or the NADPH oxidase inhibitors apocynine or diphenylene iodonium. Thus, peroxynitrite is a major trigger of DOX-induced cell death both in vivo and in vivo, and the modulation of the pathways leading to its generation or its effective neutralization can be of significant therapeutic benefit. JF - American journal of physiology. Heart and circulatory physiology AU - Mukhopadhyay, Partha AU - Rajesh, Mohanraj AU - Bátkai, Sándor AU - Kashiwaya, Yoshihiro AU - Haskó, György AU - Liaudet, Lucas AU - Szabó, Csaba AU - Pacher, Pál AD - Section on Oxidative Stress and Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC-9413, Bethesda, MD 20892-9413, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - H1466 EP - H1483 VL - 296 IS - 5 SN - 0363-6135, 0363-6135 KW - Antibiotics, Antineoplastic KW - 0 KW - Antioxidants KW - Enzyme Inhibitors KW - Free Radical Scavengers KW - Nitric Oxide Donors KW - Superoxides KW - 11062-77-4 KW - Peroxynitrous Acid KW - 14691-52-2 KW - Nitric Oxide KW - 31C4KY9ESH KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Doxorubicin KW - 80168379AG KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Nos2 protein, mouse KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Mmp2 protein, mouse KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Mmp9 protein, mouse KW - Index Medicus KW - Animals KW - Nitric Oxide Synthase Type II -- deficiency KW - Myocardial Contraction -- drug effects KW - Matrix Metalloproteinase 2 -- metabolism KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Mice, Knockout KW - Nitric Oxide Donors -- pharmacology KW - Matrix Metalloproteinase 9 -- metabolism KW - Necrosis KW - Nitric Oxide Synthase Type II -- antagonists & inhibitors KW - Mitochondria, Heart -- drug effects KW - Mitochondria, Heart -- metabolism KW - Tyrosine -- analogs & derivatives KW - Tyrosine -- metabolism KW - Male KW - Free Radical Scavengers -- pharmacology KW - Ventricular Function, Left -- drug effects KW - Dose-Response Relationship, Drug KW - Mice KW - Mitochondria, Heart -- pathology KW - Antioxidants -- metabolism KW - Ventricular Pressure -- drug effects KW - Mice, Inbred C57BL KW - Enzyme Inhibitors -- pharmacology KW - Nitric Oxide Synthase Type II -- genetics KW - Cell Line KW - Peroxynitrous Acid -- metabolism KW - Myocytes, Cardiac -- drug effects KW - Heart Diseases -- chemically induced KW - Heart Diseases -- metabolism KW - Nitric Oxide -- metabolism KW - Doxorubicin -- toxicity KW - Heart Diseases -- prevention & control KW - Myocytes, Cardiac -- pathology KW - Antibiotics, Antineoplastic -- toxicity KW - Superoxides -- metabolism KW - Apoptosis -- drug effects KW - Heart Diseases -- physiopathology KW - Heart Diseases -- pathology KW - Myocytes, Cardiac -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67197821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Heart+and+circulatory+physiology&rft.atitle=Role+of+superoxide%2C+nitric+oxide%2C+and+peroxynitrite+in+doxorubicin-induced+cell+death+in+vivo+and+in+vitro.&rft.au=Mukhopadhyay%2C+Partha%3BRajesh%2C+Mohanraj%3BB%C3%A1tkai%2C+S%C3%A1ndor%3BKashiwaya%2C+Yoshihiro%3BHask%C3%B3%2C+Gy%C3%B6rgy%3BLiaudet%2C+Lucas%3BSzab%C3%B3%2C+Csaba%3BPacher%2C+P%C3%A1l&rft.aulast=Mukhopadhyay&rft.aufirst=Partha&rft.date=2009-05-01&rft.volume=296&rft.issue=5&rft.spage=H1466&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Heart+and+circulatory+physiology&rft.issn=03636135&rft_id=info:doi/10.1152%2Fajpheart.00795.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-19 N1 - Date created - 2009-05-04 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Mol Cell Cardiol. 2007 Mar;42(3):549-58 [17223128] Am J Pathol. 2008 Jul;173(1):2-13 [18535182] J Pharmacol Exp Ther. 2000 Jul;294(1):396-401 [10871338] Mol Cell Biochem. 2000 Apr;207(1-2):77-86 [10888230] Antioxid Redox Signal. 2001 Feb;3(1):135-45 [11291592] EMBO J. 2001 Aug 1;20(15):4107-21 [11483514] Res Commun Mol Pathol Pharmacol. 1999;106(3):193-202 [11485049] Br J Pharmacol. 2002 Feb;135(3):581-8 [11834605] J Pharmacol Exp Ther. 2002 Mar;300(3):862-7 [11861791] Cancer Res. 2002 Aug 15;62(16):4592-8 [12183413] Biochem J. 2002 Nov 1;367(Pt 3):729-40 [12139490] Free Radic Biol Med. 2002 Dec 1;33(11):1451-64 [12446202] Circulation. 2003 Feb 18;107(6):896-904 [12591762] Br J Pharmacol. 2003 Feb;138(4):532-43 [12598407] Oncol Rep. 2004 Feb;11(2):505-8 [14719091] Mol Ther. 2004 Feb;9(2):173-81 [14759801] Circulation. 2004 Mar 23;109(11):1428-33 [15023870] J Biol Chem. 1986 Mar 5;261(7):3068-74 [3005279] Circulation. 1987 Dec;76(6):1422-36 [3454658] Cancer Chemother Pharmacol. 1990;26(1):9-12 [2322993] Circulation. 1990 Oct;82(4):1352-61 [2401069] Circulation. 1994 Jun;89(6):2829-35 [8205698] FEBS Lett. 1996 Mar 18;382(3):223-8 [8605974] N Engl J Med. 1998 Sep 24;339(13):900-5 [9744975] Protein Eng. 1998 Oct;11(10):931-5 [9862213] Circulation. 2004 Nov 2;110(18):2869-74 [15505089] Toxicol Pathol. 2004 Sep-Oct;32(5):536-47 [15605432] Biochem Pharmacol. 2005 Mar 1;69(5):725-32 [15710350] Ann Clin Biochem. 2005 Mar;42(Pt 2):99-104 [15829117] Nat Protoc. 2008;3(9):1422-34 [18772869] Gastroenterology. 2008 Oct;135(4):1344-57 [18778711] Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H1956-65 [18775851] Cancer Res. 2009 Jan 15;69(2):695-9 [19147586] J Pharmacol Exp Ther. 2009 Mar;328(3):740-8 [19066339] J Mol Cell Cardiol. 2005 May;38(5):765-75 [15850570] Trends Pharmacol Sci. 2005 Jun;26(6):302-10 [15925705] Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H701-7 [15821039] Cardiovasc Res. 2006 Jan;69(1):186-97 [16157314] Int J Mol Med. 2006 Feb;17(2):369-75 [16391839] Cardiovasc Res. 2006 Feb 15;69(3):736-45 [16213474] Pharmacol Res. 2006 Apr;53(4):341-6 [16455267] Mol Cell Biochem. 2006 Apr;285(1-2):149-54 [16612575] Circulation. 2006 May 9;113(18):2211-20 [16651473] J Am Coll Cardiol. 2006 Jun 20;47(12):2444-55 [16781372] J Pharmacol Sci. 2006 Jun;101(2):151-8 [16766856] Circ Res. 2006 Jun 23;98(12):1479-89 [16709900] Eur Heart J. 2006 Aug;27(15):1868-75 [16717080] Chem Biol. 2006 Jul;13(7):765-70 [16873024] Free Radic Biol Med. 2006 Sep 15;41(6):886-95 [16934671] Mol Cancer Ther. 2006 Nov;5(11):2851-60 [17121932] J Biochem Mol Biol. 2006 Nov 30;39(6):759-65 [17129413] Annu Rev Pharmacol Toxicol. 2007;47:211-42 [17129183] Physiol Rev. 2007 Jan;87(1):315-424 [17237348] FASEB J. 2007 Jun;21(8):1788-800 [17327359] Circulation. 2007 Jul 31;116(5):506-14 [17638931] Nat Rev Drug Discov. 2007 Aug;6(8):662-80 [17667957] Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H909-18 [17434980] J Am Coll Cardiol. 2007 Aug 7;50(6):528-36 [17678736] Nat Protoc. 2007;2(9):2295-301 [17853886] Cardiovasc Drug Rev. 2007 Fall;25(3):235-60 [17919258] J Leukoc Biol. 2007 Dec;82(6):1382-9 [17652447] Circ Res. 2008 Feb 29;102(4):488-96 [18096818] Free Radic Res. 2008 Jun;42(6):533-43 [18569011] Biochem Biophys Res Commun. 2007 Jun 22;358(1):203-8 [17475217] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1152/ajpheart.00795.2008 ER - TY - JOUR T1 - Intramolecular disulfide bonds of the prolactin receptor short form are required for its inhibitory action on the function of the long form of the receptor. AN - 67191178; 19273600 AB - The short form (S1b) of the prolactin receptor (PRLR) silences prolactin-induced activation of gene transcription by the PRLR long form (LF). The functional and structural contributions of two intramolecular disulfide (S-S) bonds within the extracellular subdomain 1 (D1) of S1b to its inhibitory function on the LF were investigated. Mutagenesis of the paired cysteines eliminated the inhibitory action of S1b. The expression of the mutated S1b (S1bx) on the cell surface was not affected, indicating native-like folding of the receptor. The constitutive JAK2 phosphorylation observed in S1b was not present in cells expressing S1bx, and JAK2 association was disrupted. BRET(50) (BRET(50) represents the relative affinity as acceptor/donor ratio required to reach half-maximal BRET [bioluminescence resonance energy transfer] values) showed decreased LF/S1bx heterodimeric-association and increased affinity in S1bx homodimerization, thus favoring LF homodimerization and prolactin-induced signaling. Computer modeling based on the PRLR crystal structure showed that minor changes in the tertiary structure of D1 upon S-S bond disruption propagated to the quaternary structure of the homodimer, affecting the dimerization interface. These changes explain the higher homodimerization affinity of S1bx and provide a structural basis for its lack of inhibitory function. The PRLR conformation as stabilized by S-S bonds is required for the inhibitory action of S1b on prolactin-induced LF-mediated function and JAK2 association. JF - Molecular and cellular biology AU - Xie, Y-L AU - Hassan, S A AU - Qazi, A M AU - Tsai-Morris, C H AU - Dufau, M L AD - Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-4510, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 2546 EP - 2555 VL - 29 IS - 10 KW - Disulfides KW - 0 KW - Protein Isoforms KW - Receptors, Prolactin KW - Prolactin KW - 9002-62-4 KW - Janus Kinase 2 KW - EC 2.7.10.2 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Cysteine -- metabolism KW - Models, Molecular KW - Dimerization KW - Humans KW - Transcription, Genetic KW - Janus Kinase 2 -- genetics KW - Protein Multimerization KW - Mutagenesis, Site-Directed KW - Genes, Reporter KW - Janus Kinase 2 -- metabolism KW - Mutation KW - Cell Line KW - Prolactin -- metabolism KW - Disulfides -- chemistry KW - Receptors, Prolactin -- metabolism KW - Protein Isoforms -- chemistry KW - Receptors, Prolactin -- chemistry KW - Protein Isoforms -- metabolism KW - Gene Expression Regulation KW - Protein Isoforms -- genetics KW - Receptors, Prolactin -- genetics KW - Protein Conformation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67191178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Intramolecular+disulfide+bonds+of+the+prolactin+receptor+short+form+are+required+for+its+inhibitory+action+on+the+function+of+the+long+form+of+the+receptor.&rft.au=Xie%2C+Y-L%3BHassan%2C+S+A%3BQazi%2C+A+M%3BTsai-Morris%2C+C+H%3BDufau%2C+M+L&rft.aulast=Xie&rft.aufirst=Y-L&rft.date=2009-05-01&rft.volume=29&rft.issue=10&rft.spage=2546&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.01716-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-04 N1 - Date created - 2009-05-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1999 Dec 10;274(50):35461-8 [10585417] J Chem Inf Model. 2008 Sep;48(9):1920-9 [18698840] J Biol Chem. 2000 Dec 15;275(50):39073-80 [10991949] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4379-84 [11296286] J Biol Chem. 2001 Nov 2;276(44):41086-94 [11518703] Endocrinology. 2002 Jun;143(6):2139-42 [12021177] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9858-63 [12105275] J Biol Chem. 2002 Aug 23;277(34):31107-14 [12060651] Proteins. 2003 Apr 1;51(1):109-25 [12596268] Mol Endocrinol. 2003 Nov;17(11):2268-82 [12907754] J Am Chem Soc. 2004 Jan 28;126(3):698-9 [14733527] Cancer Res. 2004 Aug 15;64(16):5677-82 [15313907] Adv Exp Med Biol. 2004;554:495-9 [15384631] Biochem Biophys Res Commun. 1989 Oct 31;164(2):788-95 [2554900] J Biol Chem. 1991 Sep 5;266(25):16472-7 [1885580] Nature. 1994 Dec 1;372(6505):478-81 [7984244] Mol Cell Biol. 1995 Feb;15(2):954-63 [7529876] Trends Genet. 1995 Feb;11(2):69-74 [7716810] J Biol Chem. 1995 May 5;270(18):10664-70 [7537736] Mol Endocrinol. 1995 Dec;9(12):1750-9 [8614411] Endocr Rev. 1998 Jun;19(3):225-68 [9626554] Science. 1999 Feb 12;283(5404):987-90 [9974392] Science. 1999 Feb 12;283(5404):990-3 [9974393] EMBO J. 1999 Mar 1;18(5):1309-20 [10064597] J Clin Endocrinol Metab. 1999 Mar;84(3):1153-6 [10084611] J Biol Chem. 1999 Oct 15;274(42):30266-72 [10514520] Proteins. 2005 Aug 15;60(3):464-84 [15959866] Mol Endocrinol. 2006 Aug;20(8):1912-23 [16556730] Proteins. 2006 Aug 15;64(3):673-90 [16729264] Mol Endocrinol. 2006 Nov;20(11):2734-46 [16840534] Curr Opin Genet Dev. 2007 Feb;17(1):8-14 [17208428] Nat Protoc. 2006;1(1):337-45 [17406254] Nat Struct Biol. 2000 Sep;7(9):808-15 [10966654] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.01716-08 ER - TY - JOUR T1 - Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. AN - 67190974; 19205035 AB - Liver fibrosis is a common scarring response to all forms of chronic liver injury and is always associated with inflammation that contributes to fibrogenesis. Although a variety of cell populations infiltrate the liver during inflammation, it is generically clear that CD8 T lymphocytes promote while natural killer (NK) cells inhibit liver fibrosis. However, the role of invariant natural killer T (iNKT) cells, which are abundant in the liver, in hepatic fibrogenesis, remains obscure. Here we show that iNKT-deficient mice are more susceptible to carbon tetrachloride (CCl(4))-induced acute liver injury and inflammation. The protective effect of naturally activated iNKT in this model is likely mediated via suppression of the proinflammatory effect of activated hepatic stellate cells. Interestingly, strong activation of iNKT through injection of iNKT activator alpha-galactosylceramide (alpha-GalCer) accelerates CCl(4)-induced acute liver injury and fibrosis. In contrast, chronic CCl(4) administration induces a similar degree of liver injury in iNKT-deficient and wild-type mice, and only a slightly higher grade of liver fibrosis in iNKT-deficient mice than wild-type mice 2 weeks but not 4 weeks after CCl(4) injection, although iNKT cells are able to kill activated stellate cells. An insignificant role of iNKT in chronic liver injury and fibrosis may be attributable to hepatic iNKT cell depletion. Finally, chronic alpha-GalCer treatment had little effect on liver injury and fibrosis, which is attributable to iNKT tolerance after alpha-GalCer injection. Natural activation of hepatic iNKT cells inhibits, whereas strong activation of iNKT cells by alpha-GalCer accelerates CCl(4)-induced acute liver injury, inflammation, and fibrosis. During chronic liver injury, hepatic iNKT cells are depleted and play a role in inhibiting liver fibrosis in the early stage but not the late stage of fibrosis. JF - Hepatology (Baltimore, Md.) AU - Park, Ogyi AU - Jeong, Won-Il AU - Wang, Lei AU - Wang, Hua AU - Lian, Zhe-Xiong AU - Gershwin, M Eric AU - Gao, Bin AD - Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1683 EP - 1694 VL - 49 IS - 5 KW - Galactosylceramides KW - 0 KW - Inflammation Mediators KW - STAT1 Transcription Factor KW - Stat1 protein, mouse KW - alpha-galactosylceramide KW - Interferon-gamma KW - 82115-62-6 KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Index Medicus KW - Animals KW - Galactosylceramides -- pharmacology KW - Carbon Tetrachloride -- metabolism KW - Mice KW - Carbon Tetrachloride -- immunology KW - Inflammation Mediators -- metabolism KW - Mice, Knockout KW - Hepatic Stellate Cells -- metabolism KW - Lymphocyte Activation -- drug effects KW - Interferon-gamma -- metabolism KW - Mice, Inbred C57BL KW - STAT1 Transcription Factor -- metabolism KW - Male KW - Liver Cirrhosis -- chemically induced KW - Liver -- immunology KW - Natural Killer T-Cells -- physiology KW - Liver Cirrhosis -- immunology KW - Chemical and Drug Induced Liver Injury -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67190974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Diverse+roles+of+invariant+natural+killer+T+cells+in+liver+injury+and+fibrosis+induced+by+carbon+tetrachloride.&rft.au=Park%2C+Ogyi%3BJeong%2C+Won-Il%3BWang%2C+Lei%3BWang%2C+Hua%3BLian%2C+Zhe-Xiong%3BGershwin%2C+M+Eric%3BGao%2C+Bin&rft.aulast=Park&rft.aufirst=Ogyi&rft.date=2009-05-01&rft.volume=49&rft.issue=5&rft.spage=1683&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.22813 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-02 N1 - Date created - 2009-05-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2001 Nov;75(22):10746-54 [11602716] J Immunol. 2005 Aug 1;175(3):1540-50 [16034092] Trends Immunol. 2003 Jul;24(7):364-9 [12860526] Int Immunol. 2004 Feb;16(2):241-7 [14734609] Gastroenterology. 2008 Jan;134(1):248-58 [18166357] Physiol Rev. 2008 Jan;88(1):125-72 [18195085] Hepatology. 2008 Feb;47(2):571-80 [18098320] Hepatology. 2008 Feb;47(2):729-36 [18167066] Hepatology. 2008 Apr;47(4):1317-30 [18220275] J Exp Med. 2005 Dec 19;202(12):1623-6 [16365145] Gastroenterology. 2006 Feb;130(2):435-52 [16472598] J Hepatol. 2006 Jul;45(1):60-71 [16515819] Hepatology. 2006 Oct;44(4):955-66 [17006930] Hepatology. 2006 Dec;44(6):1441-51 [17133483] Hepatology. 2007 Jan;45(1):242-9 [17187439] Immunity. 2007 Jan;26(1):117-29 [17239632] J Clin Invest. 2007 Mar;117(3):539-48 [17332881] Crit Rev Immunol. 2006;26(5):453-73 [17341188] Hepatology. 2007 Jun;45(6):1400-12 [17523147] J Clin Invest. 2007 Aug;117(8):2302-12 [17641782] Lab Invest. 2007 Sep;87(9):927-37 [17607300] Int Immunol. 2007 Aug;19(8):1021-9 [17698563] Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G651-6 [17627969] J Leukoc Biol. 2008 Jan;83(1):64-70 [17884993] Gastroenterology. 2008 May;134(6):1655-69 [18471545] J Leukoc Biol. 2008 Jul;84(1):264-79 [18407967] Cell. 2008 Aug 22;134(4):657-67 [18724938] Hepatology. 2008 Sep;48(3):889-97 [18712839] Hepatology. 2008 Sep;48(3):963-77 [18726940] Clin Immunol. 2009 Jan;130(1):16-26 [18823822] Gastroenterology. 2009 Mar;136(3):1048-59 [19056387] J Clin Invest. 2005 Sep;115(9):2572-83 [16138194] J Hepatol. 1999 Dec;31(6):1120-30 [10604588] Eur J Immunol. 2001 Jun;31(6):1720-7 [11385616] Gastroenterology. 2004 May;126(5):1387-99 [15131799] J Immunol. 2004 Jul 15;173(2):1417-25 [15240738] Gastroenterology. 2004 Sep;127(3):870-82 [15362042] J Leukoc Biol. 2004 Oct;76(4):743-59 [15218054] Hepatology. 2004 Nov;40(5):1033-40 [15486982] J Investig Med. 1994 Dec;42(4):660-70 [8521029] Science. 1997 Nov 28;278(5343):1623-6 [9374462] J Immunol. 1999 Nov 1;163(9):4647-50 [10528160] Gastroenterology. 2004 Dec;127(6):1760-74 [15578514] J Clin Invest. 2005 Feb;115(2):209-18 [15690074] Annu Rev Immunol. 2005;23:877-900 [15771592] Liver Int. 2005 Aug;25(4):808-16 [15998432] Gastroenterology. 2002 Oct;123(4):1031-43 [12360465] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/hep.22813 ER - TY - JOUR T1 - Identification of potential driver genes in human liver carcinoma by genomewide screening. AN - 67189532; 19366792 AB - Genomic copy number aberrations and corresponding transcriptional deregulation in the cancer genome have been suggested to have regulatory roles in cancer development and progression. However, functional evaluation of individual genes from lengthy lists of candidate genes from genomic data sets presents a significant challenge. Here, we report effective gene selection strategies to identify potential driver genes based on systematic integration of genome scale data of DNA copy numbers and gene expression profiles. Using regional pattern recognition approaches, we discovered the most probable copy number-dependent regions and 50 potential driver genes. At each step of the gene selection process, the functional relevance of the selected genes was evaluated by estimating the prognostic significance of the selected genes. Further validation using small interference RNA-mediated knockdown experiments showed proof-of-principle evidence for the potential driver roles of the genes in hepatocellular carcinoma progression (i.e., NCSTN and SCRIB). In addition, systemic prediction of drug responses implicated the association of the 50 genes with specific signaling molecules (mTOR, AMPK, and EGFR). In conclusion, the application of an unbiased and integrative analysis of multidimensional genomic data sets can effectively screen for potential driver genes and provides novel mechanistic and clinical insights into the pathobiology of hepatocellular carcinoma. JF - Cancer research AU - Woo, Hyun Goo AU - Park, Eun Sung AU - Lee, Ju-Seog AU - Lee, Yun-Han AU - Ishikawa, Tsuyoshi AU - Kim, Yoon Jun AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4262, USA. Y1 - 2009/05/01/ PY - 2009 DA - 2009 May 01 SP - 4059 EP - 4066 VL - 69 IS - 9 KW - DNA, Neoplasm KW - 0 KW - Index Medicus KW - Comparative Genomic Hybridization KW - Genome, Human KW - Humans KW - Prognosis KW - DNA, Neoplasm -- genetics KW - Transcription, Genetic KW - Gene Dosage KW - Liver Neoplasms -- pathology KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67189532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Identification+of+potential+driver+genes+in+human+liver+carcinoma+by+genomewide+screening.&rft.au=Woo%2C+Hyun+Goo%3BPark%2C+Eun+Sung%3BLee%2C+Ju-Seog%3BLee%2C+Yun-Han%3BIshikawa%2C+Tsuyoshi%3BKim%2C+Yoon+Jun%3BThorgeirsson%2C+Snorri+S&rft.aulast=Woo&rft.aufirst=Hyun&rft.date=2009-05-01&rft.volume=69&rft.issue=9&rft.spage=4059&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-0164 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-14 N1 - Date created - 2009-05-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Genet. 2002 Aug;31(4):339-46 [12149612] Gastroenterology. 2008 Dec;135(6):1972-83, 1983.e1-11 [18929564] Nat Med. 2003 Apr;9(4):416-23 [12640447] Genome Res. 2004 Jun;14(6):1085-94 [15173114] Hum Mol Genet. 2004 Jul 1;13(13):1303-13 [15138198] Bioinformatics. 2004 Jun 12;20(9):1453-4 [14871861] Hepatology. 2004 Sep;40(3):667-76 [15349906] Clin Cancer Res. 2004 Dec 15;10(24):8421-5 [15623621] Br J Cancer. 2005 Mar 14;92(5):935-41 [15756261] Oncogene. 2005 May 26;24(23):3737-47 [15735714] J Clin Oncol. 2005 Sep 20;23(27):6657-63 [16170173] Nat Genet. 2006 Apr;38(4):421-30 [16518402] Nat Med. 2006 Apr;12(4):410-6 [16532004] Cancer Cell. 2006 Apr;9(4):313-25 [16616336] Cell Cycle. 2006 Jul;5(13):1431-7 [16855393] Nat Chem Biol. 2006 Sep;2(9):458-66 [16921358] Science. 2006 Sep 29;313(5795):1929-35 [17008526] Gastroenterology. 2006 Oct;131(4):1262-70 [17030195] Cancer Cell. 2006 Oct;10(4):331-42 [17010674] Cancer Cell. 2006 Oct;10(4):321-30 [17010675] Cancer Res. 2006 Nov 1;66(21):10269-73 [17062558] Nat Genet. 2006 Dec;38(12):1386-96 [17099711] Nucleic Acids Res. 2007 Jan;35(Database issue):D727-31 [17098932] Hepatology. 2007 Apr;45(4):938-47 [17393520] Nat Genet. 2007 May;39(5):638-44 [17401364] Cancer Res. 2007 May 1;67(9):4337-45 [17483347] Blood. 2007 Jul 1;110(1):278-86 [17363738] Cancer Cell. 2007 Jul;12(1):9-22 [17613433] Cancer Res. 2007 Jul 15;67(14):6745-52 [17638885] Hum Pathol. 2007 Aug;38(8):1273-81 [17509663] Cancer. 2007 Sep 1;110(5):1059-67 [17623837] Cell. 2007 Sep 21;130(6):1005-18 [17889646] Gastroenterology. 2007 Nov;133(5):1475-86 [17983802] Br J Cancer. 2008 Mar 11;98(5):923-30 [18319715] Clin Cancer Res. 2008 Apr 1;14(7):2056-64 [18381945] Hepatology. 2008 Apr;47(4):1200-10 [18214995] Oncogene. 2008 Jun 5;27(25):3576-86 [18212742] Cancer Res. 2008 Aug 15;68(16):6779-88 [18701503] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12963-8 [12297621] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-09-0164 ER - TY - JOUR T1 - C/EBPbeta regulates body composition, energy balance-related hormones and tumor growth. AN - 67186410; 19056928 AB - The prevalence of obesity, an established epidemiologic risk factor for many chronic diseases including cancer, has been steadily increasing in the US over several decades. The mechanisms used to regulate energy balance and adiposity and the relationship of these factors to cancer are not completely understood. Here we have used knockout mice to examine the roles of the transcription factors CCAAT/enhancer-binding protein (C/EBP) beta and C/EBPdelta in regulating body composition and systemic levels of hormones such as insulin-like growth factor-1 (IGF-1), leptin and insulin that mediate energy balance. Dual-energy X-ray absorptiometry showed that C/EBPbeta, either directly or indirectly, modulated body weight, fat content and bone density in both males and females, while the effect of C/EBPdelta was minor and only affected adiposity and body weight in female animals. Levels of IGF-1, leptin and insulin in the serum were decreased in both male and female C/EBPbeta(-/-) mice, and C/EBPbeta was associated with their promoters in vivo. Moreover, colon adenocarcinoma cells displayed reduced tumorigenic potential when transplanted into C/EBPbeta-deficient animals, especially males. Thus, C/EBPbeta contributes to endocrine expression of IGF-1, leptin and insulin, which modulate energy balance and can contribute to cancer progression by creating a favorable environment for tumor cell proliferation and survival. JF - Carcinogenesis AU - Staiger, Jennifer AU - Lueben, Mary J AU - Berrigan, David AU - Malik, Radek AU - Perkins, Susan N AU - Hursting, Stephen D AU - Johnson, Peter F AD - Basic Research Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702-1201, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 832 EP - 840 VL - 30 IS - 5 KW - CCAAT-Enhancer-Binding Protein-beta KW - 0 KW - Insulin KW - Leptin KW - CCAAT-Enhancer-Binding Protein-delta KW - 142662-43-9 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Index Medicus KW - Animals KW - Insulin-Like Growth Factor I -- physiology KW - CCAAT-Enhancer-Binding Protein-delta -- physiology KW - CCAAT-Enhancer-Binding Protein-delta -- deficiency KW - Mice KW - Leptin -- physiology KW - Adipose Tissue -- physiology KW - Mice, Knockout KW - Adenocarcinoma -- pathology KW - Body Weight KW - Insulin -- physiology KW - Mice, Inbred C57BL KW - Bone Density KW - CCAAT-Enhancer-Binding Protein-delta -- genetics KW - Colonic Neoplasms -- pathology KW - Male KW - Cell Division -- genetics KW - Female KW - Obesity -- genetics KW - Body Composition -- physiology KW - Neoplasms -- epidemiology KW - CCAAT-Enhancer-Binding Protein-beta -- physiology KW - Obesity -- physiopathology KW - CCAAT-Enhancer-Binding Protein-beta -- genetics KW - CCAAT-Enhancer-Binding Protein-beta -- deficiency KW - Obesity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67186410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=C%2FEBPbeta+regulates+body+composition%2C+energy+balance-related+hormones+and+tumor+growth.&rft.au=Staiger%2C+Jennifer%3BLueben%2C+Mary+J%3BBerrigan%2C+David%3BMalik%2C+Radek%3BPerkins%2C+Susan+N%3BHursting%2C+Stephen+D%3BJohnson%2C+Peter+F&rft.aulast=Staiger&rft.aufirst=Jennifer&rft.date=2009-05-01&rft.volume=30&rft.issue=5&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn273 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-20 N1 - Date created - 2009-05-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Clin Nutr. 2001 Sep;74(3):295-301 [11522551] Growth Horm IGF Res. 2001 Aug;11(4):213-9 [11735236] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):207-12 [11756662] Pituitary. 2001 Jan-Apr;4(1-2):63-70 [11824509] Growth Horm IGF Res. 2001 Dec;11(6):339-45 [11914021] J Biol Chem. 2002 May 3;277(18):15261-70 [11825899] Carcinogenesis. 2002 May;23(5):817-22 [12016155] Lancet Oncol. 2002 May;3(5):298-302 [12067807] Biochem J. 2002 Aug 1;365(Pt 3):561-75 [12006103] Lancet Oncol. 2002 Sep;3(9):565-74 [12217794] Oncology. 2002;63(4):317-32 [12417786] Breast Cancer Res. 2002;4(6):231-9 [12473169] Annu Rev Med. 2003;54:131-52 [12525670] J Urol. 2003 Feb;169(2):714-7 [12544349] J Urol. 2003 Apr;169(4):1308-11 [12629349] Cancer Res. 2003 Apr 15;63(8):1752-5 [12702556] N Engl J Med. 2003 Apr 24;348(17):1625-38 [12711737] Cancer Res. 2003 Aug 1;63(15):4384-8 [12907608] Int J Cancer. 2004 Mar10;109(1):149-52 [14735482] Mol Cell Biol. 2004 Apr;24(8):3238-50 [15060147] Clin Cancer Res. 2004 Jul 1;10(13):4325-31 [15240518] Nat Rev Cancer. 2004 Aug;4(8):579-91 [15286738] Obes Res. 2004 Sep;12(9):1481-91 [15483213] Cancer Res. 1975 Sep;35(9):2434-9 [1149045] Diabetologia. 1978 Mar;14(3):141-8 [350680] Endocrinology. 1989 Mar;124(3):1247-53 [2645113] Endocrinology. 1991 Jun;128(6):2895-900 [1645254] Genes Dev. 1991 Sep;5(9):1538-52 [1840554] Genomics. 1991 Dec;11(4):1054-62 [1686014] Genes Dev. 1992 Apr;6(4):533-44 [1373117] Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4874-8 [1594587] Endocrinology. 1992 Jun;130(6):3608-16 [1597158] Immunol Rev. 1992 Jun;127:25-50 [1380488] Cancer Res. 1994 Sep 15;54(18):4848-50 [8069850] Nature. 1994 Dec 1;372(6505):425-32 [7984236] Ann Intern Med. 1995 Jan 1;122(1):54-9 [7619109] Cancer Res. 1995 Jan 15;55(2):249-52 [7812953] Genes Dev. 1995 Jan 15;9(2):168-81 [7531665] N Engl J Med. 1996 Feb 1;334(5):292-5 [8532024] Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):873-7 [8570651] Nat Genet. 1996 Mar;12(3):318-20 [8589726] Endocrinology. 1996 May;137(5):1764-74 [8612513] Diabetes. 1996 Jul;45(7):984-7 [8666153] J Biol Chem. 1997 Jan 3;272(1):154-61 [8995241] J Clin Invest. 1997 Feb 1;99(3):391-5 [9022071] Diabetes. 1997 Mar;46(3):342-7 [9032087] Int J Obes Relat Metab Disord. 1997 Apr;21(4):255-60 [9130020] Genes Dev. 1997 Sep 1;11(17):2153-62 [9303532] J Biol Chem. 1997 Nov 7;272(45):28349-59 [9353292] J Biol Chem. 1997 Dec 12;272(50):31793-800 [9395525] EMBO J. 1997 Dec 15;16(24):7432-43 [9405372] Endocrinology. 1998 Mar;139(3):1013-22 [9492033] Clin Chem. 1998 Mar;44(3):565-70 [9510863] Science. 1998 May 29;280(5368):1378-83 [9603721] Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10908-13 [9724803] J Biol Chem. 1998 Nov 6;273(45):29279-82 [9792624] Circ Res. 1998 Nov 16;83(10):1059-66 [9815153] J Biol Chem. 1999 Apr 9;274(15):10609-17 [10187857] Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):679-85 [15681294] Cancer Res. 2005 Apr 1;65(7):2592-601 [15805255] In Vivo. 2005 Jul-Aug;19(4):667-74 [15999532] J Biol Chem. 2005 Jul 22;280(29):26751-9 [15899886] Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1646-52 [16030096] Cytokine Growth Factor Rev. 2005 Aug-Oct;16(4-5):407-20 [15886048] EMBO J. 2005 Sep 21;24(18):3301-12 [16107878] Oncogene. 2006 Feb 23;25(8):1272-6 [16205634] Clin Cancer Res. 2006 Mar 1;12(5):1447-53 [16533767] JAMA. 2006 Apr 5;295(13):1549-55 [16595758] Cell Cycle. 2006 May;5(9):953-7 [16687924] Clin Cancer Res. 2006 Oct 1;12(19):5611-4 [17020962] Endocrinology. 2006 Dec;147(12):5826-34 [16959846] J Clin Invest. 2006 Dec;116(12):3171-82 [17111047] Mol Cancer Ther. 2007 Jan;6(1):1-12 [17237261] J Biol Chem. 2007 May 25;282(21):15717-29 [17387171] Science. 2007 Jul 6;317(5834):121-4 [17615358] Curr Cancer Drug Targets. 2007 Aug;7(5):484-91 [17691908] Brain Res. 1999 Nov 27;848(1-2):114-23 [10612703] J Neurosci. 2000 Aug 1;20(15):5703-8 [10908609] Obes Res. 2000 Aug;8(5):392-8 [10968731] Science. 2000 Sep 22;289(5487):2122-5 [11000114] Prostate. 2001 Jan 1;46(1):62-7 [11170133] J Biol Chem. 2001 May 4;276(18):15354-61 [11278589] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn273 ER - TY - JOUR T1 - Propofol anesthesia does not alter regional rates of cerebral protein synthesis measured with L-[1-(11)C]leucine and PET in healthy male subjects. AN - 67183368; 19223912 AB - We report regional rates of cerebral protein synthesis (rCPS) in 10 healthy young males, each studied under two conditions: awake and anesthetized with propofol. We used the quantitative L-[1-(11)C]leucine positron emission tomography (PET) method to measure rCPS. The method accounts for the fraction (lambda) of unlabeled leucine in the precursor pool for protein synthesis that is derived from arterial plasma; the remainder comes from proteolysis of tissue proteins. Across 18 regions and whole brain, mean differences in rCPS between studies ranged from -5% to 5% and were within the variability of rCPS in awake studies (coefficient of variation range: 7% to 14%). Similarly, differences in lambda (range: 1% to 4%) were typically within the variability of lambda (coefficient of variation range: 3% to 6%). Intersubject variances and patterns of regional variation were also similar under both conditions. In propofol-anesthetized subjects, rCPS varied regionally from 0.98+/-0.12 to 2.39+/-0.23 nmol g(-1) min(-1) in the corona radiata and in the cerebellum, respectively. Our data indicate that the values, variances, and patterns of regional variation in rCPS and lambda measured by the L-[1-(11)C]leucine PET method are not significantly altered by anesthesia with propofol. JF - Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism AU - Bishu, Shrinivas AU - Schmidt, Kathleen C AU - Burlin, Thomas V AU - Channing, Michael A AU - Horowitz, Lisa AU - Huang, Tianjiang AU - Liu, Zhong-hua AU - Qin, Mei AU - Vuong, B-K AU - Unterman, Aaron J AU - Xia, Zengyan AU - Zametkin, Alan AU - Herscovitch, Peter AU - Quezado, Zenaide AU - Smith, Carolyn B AD - Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health, Bethesda, Maryland 20892-1298, USA. bishus@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1035 EP - 1047 VL - 29 IS - 5 KW - Anesthetics, Intravenous KW - 0 KW - Carbon Radioisotopes KW - Leucine KW - GMW67QNF9C KW - Propofol KW - YI7VU623SF KW - Index Medicus KW - Magnetic Resonance Imaging KW - Young Adult KW - Prospective Studies KW - Cognition -- drug effects KW - Memory -- drug effects KW - Kinetics KW - Humans KW - Adult KW - Leucine -- administration & dosage KW - Male KW - Leucine -- blood KW - Protein Biosynthesis -- drug effects KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- metabolism KW - Anesthesia, Intravenous -- adverse effects KW - Positron-Emission Tomography -- methods KW - Anesthetics, Intravenous -- adverse effects KW - Propofol -- adverse effects KW - Cerebral Cortex -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67183368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cerebral+blood+flow+and+metabolism+%3A+official+journal+of+the+International+Society+of+Cerebral+Blood+Flow+and+Metabolism&rft.atitle=Propofol+anesthesia+does+not+alter+regional+rates+of+cerebral+protein+synthesis+measured+with+L-%5B1-%2811%29C%5Dleucine+and+PET+in+healthy+male+subjects.&rft.au=Bishu%2C+Shrinivas%3BSchmidt%2C+Kathleen+C%3BBurlin%2C+Thomas+V%3BChanning%2C+Michael+A%3BHorowitz%2C+Lisa%3BHuang%2C+Tianjiang%3BLiu%2C+Zhong-hua%3BQin%2C+Mei%3BVuong%2C+B-K%3BUnterman%2C+Aaron+J%3BXia%2C+Zengyan%3BZametkin%2C+Alan%3BHerscovitch%2C+Peter%3BQuezado%2C+Zenaide%3BSmith%2C+Carolyn+B&rft.aulast=Bishu&rft.aufirst=Shrinivas&rft.date=2009-05-01&rft.volume=29&rft.issue=5&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Journal+of+cerebral+blood+flow+and+metabolism+%3A+official+journal+of+the+International+Society+of+Cerebral+Blood+Flow+and+Metabolism&rft.issn=1559-7016&rft_id=info:doi/10.1038%2Fjcbfm.2009.7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-15 N1 - Date created - 2009-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anesthesiology. 1999 Dec;91(6):1720-3 [10598615] Anesthesiology. 1990 Sep;73(3):499-505 [2393135] Nucl Med Biol. 2003 Jan;30(1):39-44 [12493541] Acta Anaesthesiol Scand. 2003 Aug;47(7):833-7 [12859304] Anesth Analg. 2004 Aug;99(2):399-408, table of contents [15271714] Experientia. 1964 Feb 15;20(2):98-9 [5852169] Biochim Biophys Acta. 1976 Apr 2;425(4):511-20 [1259983] J Neurochem. 1977 May;28(5):897-916 [864466] Fed Proc. 1981 Jun;40(8):2311-6 [7238911] Anesthesiology. 1982 Aug;57(2):87-93 [7091748] Mol Pharmacol. 1983 Sep;24(2):277-81 [6888370] J Cereb Blood Flow Metab. 1991 Jan;11(1):10-24 [1983993] Anesthesiology. 1995 Feb;82(2):393-403; discussion 27A [7856898] Glia. 1997 Sep;21(1):92-8 [9298851] Anesthesiology. 1997 Oct;87(4):808-15 [9357882] Am J Physiol. 1998 May;274(5 Pt 1):E852-9 [9612243] Psychiatry Res. 1998 Jun 15;79(2):163-73 [9705054] J Neurosci. 1999 Jul 1;19(13):5506-13 [10377359] Proc R Soc Lond B Biol Sci. 1956 Mar 27;144(918):83-99 [13310586] Anesthesiology. 2005 Jan;102(1):57-62 [15618787] J Cereb Blood Flow Metab. 2005 May;25(5):617-28 [15703696] J Cereb Blood Flow Metab. 2005 May;25(5):629-40 [15703697] Am J Physiol Endocrinol Metab. 2006 May;290(5):E882-8 [16352675] Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1267-75 [16434554] J Neurosci. 2007 Mar 21;27(12):3090-7 [17376970] Semin Pediatr Neurol. 2007 Sep;14(3):108-17 [17980307] Neuron. 2007 Nov 8;56(3):422-37 [17988628] Psychol Assess. 2007 Dec;19(4):369-81 [18085930] Handb Exp Pharmacol. 2008;(182):227-52 [18175094] Neuropathol Appl Neurobiol. 2008 Feb;34(1):4-11 [17971078] J Cereb Blood Flow Metab. 2008 Jul;28(7):1388-98 [18431402] J Cereb Blood Flow Metab. 2008 Aug;28(8):1502-13 [18493259] Methods Inf Med. 2004;43(4):327-30 [15472742] J Cereb Blood Flow Metab. 1984 Sep;4(3):458-65 [6432811] J Neurochem. 1987 Feb;48(2):352-63 [3794710] J Neurochem. 1987 Nov;49(5):1651-8 [3668544] J Cereb Blood Flow Metab. 1987 Dec;7(6):709-19 [3121647] J Cereb Blood Flow Metab. 1988 Apr;8(2):285-8 [3257762] Anesthesiology. 1988 Sep;69(3):319-26 [3046437] Int J Geriatr Psychiatry. 2000 Apr;15(4):317-24 [10767731] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/jcbfm.2009.7 ER - TY - JOUR T1 - Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein. AN - 67182901; 19372478 AB - P-glycoprotein (P-gp) is a membrane-bound efflux pump that limits the distribution of drugs to several organs of the body. At the blood-brain barrier, P-gp blocks the entry of both loperamide and its metabolite, N-desmethyl-loperamide (N-dLop), and thereby prevents central opiate effects. Animal studies have shown that (11)C-dLop, compared with (11)C-loperamide, is an especially promising radiotracer because it generates negligible radiometabolites that enter the brain. The purposes of this study were to determine whether (11)C-dLop is a substrate for P-gp at the blood-brain barrier in humans and to measure the distribution of radioactivity in the entire body to estimate radiation exposure. Brain PET scans were acquired in 4 healthy subjects for 90 min and included concurrent measurements of the plasma concentration of unchanged radiotracer. Time-activity data from the whole brain were quantified using a 1-tissue-compartment model to estimate the rate of entry (K(1)) of radiotracer into the brain. Whole-body PET scans were acquired in 8 healthy subjects for 120 min. For brain imaging, after the injection of (11)C-dLop the concentration of radioactivity in the brain was low (standardized uptake value, approximately 15%) and stable after approximately 20 min. In contrast, uptake of radioactivity in the pituitary was about 50-fold higher than that in the brain. The plasma concentration of (11)C-dLop declined rapidly, but the percentage composition of plasma was unusually stable, with the parent radiotracer constituting 85% of total radioactivity after approximately 5 min. The rate of brain entry was low (K(1) = 0.009 +/- 0.002 mL.cm(-3).min(-1); n = 4). For whole-body imaging, as a measure of radiation exposure to the entire body the effective dose of (11)C-dLop was 7.8 +/- 0.6 muSv/MBq (n = 8). The low brain uptake of radioactivity is consistent with (11)C-dLop being a substrate for P-gp in humans and confirms that this radiotracer generates negligible quantities of brain-penetrant radiometabolites. In addition, the low rate of K(1) is consistent with P-gp rapidly effluxing substrates while they transit through the lipid bilayer. The radiation exposure of (11)C-dLop is similar to that of many other (11)C-radiotracers. Thus, (11)C-dLop is a promising radiotracer to study the function of P-gp at the blood-brain barrier, at which impaired function would allow increased uptake into the brain. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Seneca, Nicholas AU - Zoghbi, Sami S AU - Liow, Jeih-San AU - Kreisl, William AU - Herscovitch, Peter AU - Jenko, Kimberly AU - Gladding, Robert L AU - Taku, Andrew AU - Pike, Victor W AU - Innis, Robert B AD - National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 807 EP - 813 VL - 50 IS - 5 SN - 0161-5505, 0161-5505 KW - N-demethylloperamide KW - 0 KW - P-Glycoprotein KW - Radiopharmaceuticals KW - Loperamide KW - 6X9OC3H4II KW - Index Medicus KW - Radiopharmaceuticals -- pharmacokinetics KW - Radiation Dosage KW - Radiometry KW - Humans KW - Adult KW - Metabolic Clearance Rate KW - Organ Specificity KW - Tissue Distribution KW - Male KW - Female KW - Positron-Emission Tomography -- methods KW - P-Glycoprotein -- metabolism KW - Loperamide -- analogs & derivatives KW - Body Burden KW - Loperamide -- pharmacokinetics KW - Brain -- metabolism KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67182901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Human+brain+imaging+and+radiation+dosimetry+of+11C-N-desmethyl-loperamide%2C+a+PET+radiotracer+to+measure+the+function+of+P-glycoprotein.&rft.au=Seneca%2C+Nicholas%3BZoghbi%2C+Sami+S%3BLiow%2C+Jeih-San%3BKreisl%2C+William%3BHerscovitch%2C+Peter%3BJenko%2C+Kimberly%3BGladding%2C+Robert+L%3BTaku%2C+Andrew%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Seneca&rft.aufirst=Nicholas&rft.date=2009-05-01&rft.volume=50&rft.issue=5&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/10.2967%2Fjnumed.108.058453 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-20 N1 - Date created - 2009-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Nucl Med. 2003 Aug;44(8):1330-9 [12902425] J Nucl Med. 2009 Jan;50(1):108-15 [19091890] Cancer Res. 1993 Mar 1;53(5):977-84 [8094997] J Pharm Sci. 1994 Jul;83(7):1014-9 [7965658] Nucl Med Biol. 2005 Jan;32(1):87-93 [15691665] J Nucl Med. 2005 Jun;46(6):1023-7 [15937315] Mol Imaging. 2005 Jan-Mar;4(1):30-9 [15967124] J Pharmacol Exp Ther. 2006 Feb;316(2):647-53 [16293715] J Nucl Med. 2006 Mar;47(3):520-7 [16513622] J Nucl Med. 2006 Sep;47(9):1531-7 [16954563] J Nucl Med. 2007 Jan;48(1):100-7 [17204705] J Cereb Blood Flow Metab. 2007 Feb;27(2):424-33 [16757979] J Nucl Med. 2007 Dec;48(12):2072-9 [18006619] J Nucl Med. 2008 Apr;49(4):649-56 [18344435] Nucl Med Biol. 2008 May;35(4):493-500 [18482687] J Med Chem. 2008 Oct 9;51(19):6034-43 [18783208] Trends Pharmacol Sci. 2004 Aug;25(8):423-9 [15276711] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2967/jnumed.108.058453 ER - TY - JOUR T1 - Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study. AN - 67180374; 19397459 AB - To determine the electrocardiographic effects of coadministration of lofexidine and methadone. Prospective, double-blind study. Outpatient drug treatment research clinic. Fourteen adults (mean +/- SD age 34.9 +/- 5.3 yrs) with physical dependence on opioids. Participants were stabilized on methadone maintenance therapy, reaching a target dose of 80 mg/day. After 3 weeks of methadone stabilization, participants received lofexidine 0.4 mg or placebo once/day, each for 1 week, administered at the same time as methadone. From weeks 3-8, all subjects received lofexidine, with the dose escalated each week in 0.2-mg increments so that by week 8, participants were receiving lofexidine 1.6 mg/day. Electrocardiograms (ECGs) were obtained at baseline (before methadone), after stabilization with methadone, and after lofexidine coadministration during peak plasma lofexidine levels. Prespecified outcome measures of mean and maximal changes in heart rate, and PR, QRS, and QTc intervals were obtained after stabilization with methadone and after lofexidine 0.4 mg coadministration. Repeated-measures regression showed no significant changes in heart rate or PR, QRS, or QTc interval after methadone stabilization, but a significant decrease in heart rate (mean +/- SD -8.0 +/- 7.3 beats/min, p=0.0006) after starting lofexidine. When data were analyzed by using maximal ECG response, again, no significant changes were noted during methadone induction compared with baseline, but significant changes did occur in all four ECG parameters when lofexidine was coadministered: decreased heart rate (mean +/- SD -9.6 +/- 5.8 beats/min, p 40 msec). Our preliminary data suggest that coadministration of lofexidine and methadone induces QTc interval prolongation. This drug combination should be prescribed cautiously, with ECG monitoring. Furthermore, because the participants with the largest changes in QTc interval in our study were female, women may be at highest risk. JF - Pharmacotherapy AU - Schmittner, John AU - Schroeder, Jennifer R AU - Epstein, David H AU - Krantz, Mori J AU - Eid, Nicole C AU - Preston, Kenzie L AD - Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 495 EP - 502 VL - 29 IS - 5 KW - Narcotic Antagonists KW - 0 KW - Clonidine KW - MN3L5RMN02 KW - Methadone KW - UC6VBE7V1Z KW - lofexidine KW - UI82K0T627 KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Administration Schedule KW - Sex Characteristics KW - Risk Factors KW - Humans KW - Adult KW - Pilot Projects KW - Opioid-Related Disorders -- drug therapy KW - Male KW - Female KW - Narcotic Antagonists -- administration & dosage KW - Methadone -- adverse effects KW - Narcotic Antagonists -- adverse effects KW - Clonidine -- analogs & derivatives KW - Clonidine -- administration & dosage KW - Clonidine -- adverse effects KW - Methadone -- administration & dosage KW - Electrocardiography -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67180374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Electrocardiographic+effects+of+lofexidine+and+methadone+coadministration%3A+secondary+findings+from+a+safety+study.&rft.au=Schmittner%2C+John%3BSchroeder%2C+Jennifer+R%3BEpstein%2C+David+H%3BKrantz%2C+Mori+J%3BEid%2C+Nicole+C%3BPreston%2C+Kenzie+L&rft.aulast=Schmittner&rft.aufirst=John&rft.date=2009-05-01&rft.volume=29&rft.issue=5&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=1875-9114&rft_id=info:doi/10.1592%2Fphco.29.5.495 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-09 N1 - Date created - 2009-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Cardiol. 2005 Apr 1;95(7):915-8 [15781034] BMJ. 2004 Nov 6;329(7474):1075 [15528619] Addict Biol. 2005 Jun;10(2):149-55 [16191667] Fed Regist. 2005 Oct 20;70(202):61134-5 [16237860] Lancet. 2006 Aug 12;368(9535):556-7 [16905001] Am J Cardiol. 2006 Oct 15;98(8):1121 [17027587] Psychopharmacology (Berl). 2007 Mar;190(4):569-74 [17136399] Pharmacotherapy. 2007 Aug;27(8):1111-9 [17655511] J Cardiovasc Electrophysiol. 2007 Sep;18(9):960-4 [17666066] Pharmacotherapy. 2008 Nov;28(11):1315-24 [18956991] Neuropsychopharmacology. 2000 Aug;23(2):138-50 [10882840] Neuropsychopharmacology. 2001 Sep;25(3):320-31 [11522461] J Addict Dis. 2002;21(3):1-12 [12094996] J Pharmacol Exp Ther. 2002 Nov;303(2):688-94 [12388652] Pharmacotherapy. 2003 Jun;23(6):802-5 [12820821] N Engl J Med. 2004 Mar 4;350(10):1013-22 [14999113] Cochrane Database Syst Rev. 2004;(4):CD002024 [15495025] J Pharmacol Exp Ther. 1977 Sep;202(3):646-53 [894527] Gen Pharmacol. 1979;10(3):195-200 [467958] J Pharmacol Exp Ther. 1980 Oct;215(1):259-65 [6109016] Clin Pharmacol Ther. 1981 Aug;30(2):239-45 [7249508] Arzneimittelforschung. 1982;32(8a):931-40 [6890367] Fundam Appl Toxicol. 1983 Nov-Dec;3(6):536-42 [6662295] Pacing Clin Electrophysiol. 1993 Jan;16(1 Pt 1):33-8 [7681173] Eur Addict Res. 1999 Mar;5(1):43-9 [10085500] Psychopharmacology (Berl). 2005 May;179(2):366-73 [15551068] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1592/phco.29.5.495 ER - TY - JOUR T1 - C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation. AN - 67179859; 19144510 AB - Pharmacogenetics represents an exciting, new promising tool for the individualisation of therapy. Several genetic polymorphisms and haplotypes have been considered in an attempt to optimise therapy with specific drugs but, up to now, their clinical applications remain limited. 5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme of one-carbon metabolism, catalyses the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Two common non-synonymous variants, the C677T (Ala222Val) and A1298C (Glu429Ala), were described for the MTHFR gene and associated with a decreased enzymatic activity and an alteration of intracellular folate distribution. Other MTHFR polymorphisms with marginal impact on enzymatic activity were also reported. Several published clinical studies have investigated the potential predictive role of C677T and A1298C genetic variants on toxicity and efficacy of antifolate and fluoropyrimidine agents, such as methotrexate (MTX), 5-fluorouracil (5-FU) and raltitrexed. Many of these studies show significant associations with MTHFR variants, but others report neither association nor opposite results. A significant interaction between MTHFR polymorphisms and nutrient/environmental factors (i.e. folate status) as well as the ethnicity was reported. Finally, a haplotype approach and the combined analysis of multiple folate pathway gene variants seem to provide a more comprehensive strategy compared to single-locus investigations. The aim of this review is to critically analyse the available data on the importance of MTHFR polymorphisms in modulating the clinical outcome of antifolate and fluoropyrimidine therapies. JF - European journal of cancer (Oxford, England : 1990) AU - De Mattia, Elena AU - Toffoli, Giuseppe AD - Experimental and Clinical Pharmacology Unit, CRO - National Cancer Institute, via Franco Gallini, 2-33081 Aviano (PN), Italy. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1333 EP - 1351 VL - 45 IS - 8 KW - Antimetabolites, Antineoplastic KW - 0 KW - Folic Acid Antagonists KW - Quinazolines KW - Thiophenes KW - Methylenetetrahydrofolate Reductase (NADPH2) KW - EC 1.5.1.20 KW - raltitrexed KW - FCB9EGG971 KW - Fluorouracil KW - U3P01618RT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Fluorouracil -- therapeutic use KW - Animals KW - Thiophenes -- therapeutic use KW - Humans KW - Treatment Outcome KW - Quinazolines -- therapeutic use KW - Methotrexate -- therapeutic use KW - Pharmacogenetics -- methods KW - Drug Resistance, Neoplasm -- drug effects KW - Neoplasms -- drug therapy KW - Folic Acid Antagonists -- therapeutic use KW - Polymorphism, Genetic KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Neoplasms -- genetics KW - Methylenetetrahydrofolate Reductase (NADPH2) -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67179859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.atitle=C677T+and+A1298C+MTHFR+polymorphisms%2C+a+challenge+for+antifolate+and+fluoropyrimidine-based+therapy+personalisation.&rft.au=De+Mattia%2C+Elena%3BToffoli%2C+Giuseppe&rft.aulast=De+Mattia&rft.aufirst=Elena&rft.date=2009-05-01&rft.volume=45&rft.issue=8&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.issn=1879-0852&rft_id=info:doi/10.1016%2Fj.ejca.2008.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-28 N1 - Date created - 2009-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ejca.2008.12.004 ER - TY - JOUR T1 - Novel oncogenic actions of TRbeta mutants in tumorigenesis. AN - 67178790; 19391168 AB - The thyroid hormone, T3, plays important roles in metabolism, growth, and differentiation. Germline mutations in thyroid hormone receptor beta (TRbeta) have been identified in many individuals with resistance to thyroid hormone, a syndrome of reduced sensitivity to T3. A close association of somatic mutations of TRbeta with several human cancers has become increasingly apparent, but how TRbeta mutants could be involved in the carcinogenesis in vivo has not been addressed. The creation of a mouse model (TRbeta(PV/PV) mouse) that harbors a knockin mutation of TRbeta (denoted TRbetaPV) has facilitated the study of the molecular actions of TRbeta mutants in vivo. The striking phenotype of thyroid cancer and the development of pituitary tumors exhibited by TRbeta(PV/PV) mice have uncovered novel functions of a TRbeta mutant in tumorigenesis. It led to the important findings that the oncogenic action of TRbetaPV is mediated by both genomic and nongenomic actions to alter gene expression and signaling pathways activity. JF - IUBMB life AU - Guigon, Celine J AU - Cheng, Sheue-yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4264, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 528 EP - 536 VL - 61 IS - 5 KW - Thyroid Hormone Receptors beta KW - 0 KW - Cyclin D1 KW - 136601-57-5 KW - Index Medicus KW - Animals KW - Mice, Mutant Strains KW - Cyclin D1 -- metabolism KW - Mice KW - Thyroid Hormone Receptors beta -- metabolism KW - Thyroid Neoplasms -- genetics KW - Signal Transduction -- genetics KW - Mutation -- genetics KW - Pituitary Neoplasms -- genetics KW - Thyroid Hormone Receptors beta -- genetics KW - Gene Expression Regulation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67178790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IUBMB+life&rft.atitle=Novel+oncogenic+actions+of+TRbeta+mutants+in+tumorigenesis.&rft.au=Guigon%2C+Celine+J%3BCheng%2C+Sheue-yann&rft.aulast=Guigon&rft.aufirst=Celine&rft.date=2009-05-01&rft.volume=61&rft.issue=5&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=IUBMB+life&rft.issn=1521-6551&rft_id=info:doi/10.1002%2Fiub.180 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2009-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):57-66 [18328691] Prostate. 2008 May 1;68(6):610-9 [18196550] Thyroid. 2001 Mar;11(3):281-91 [11327621] Mol Cell. 2001 May;7(5):927-36 [11389840] Physiol Rev. 2001 Jul;81(3):1097-142 [11427693] Cancer Res. 2001 Aug 15;61(16):6105-11 [11507060] Mol Endocrinol. 2001 Sep;15(9):1529-38 [11518802] J Clin Endocrinol Metab. 2001 Nov;86(11):5572-6 [11701737] Carcinogenesis. 2002 Jan;23(1):25-33 [11756220] Trends Endocrinol Metab. 2002 Mar;13(2):55-60 [11854019] J Clin Endocrinol Metab. 2002 Mar;87(3):1120-8 [11889175] Cancer Res. 2002 Apr 1;62(7):1939-43 [11929806] Oncogene. 2002 Jun 20;21(27):4307-16 [12082618] Curr Biol. 2002 Jul 23;12(14):R499-R501 [12176352] BMC Cell Biol. 2001;2:5 [11312999] Biochim Biophys Acta. 2002 Oct 10;1584(2-3):73-80 [12385889] Thyroid. 2002 Nov;12(11):963-9 [12490073] Nat Rev Mol Cell Biol. 2003 May;4(5):349-60 [12728269] Endocr J. 2003 Feb;50(1):77-83 [12733712] J Biol Chem. 2003 Aug 8;278(32):29954-62 [12771132] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] Cancer Res. 2003 Sep 1;63(17):5274-80 [14500358] Mol Cell Endocrinol. 2003 Dec 31;213(1):1-11 [15062569] Endocr Rev. 2004 Apr;25(2):276-308 [15082523] J Biol Chem. 2004 Aug 20;279(34):35583-94 [15190077] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] Mol Endocrinol. 1992 Feb;6(2):248-58 [1569968] Thyroid. 1992 Winter;2(4):307-13 [1493372] Oncogene. 1994 Jul;9(7):2105-7 [8208558] J Clin Endocrinol Metab. 1994 Aug;79(2):384-9 [8045952] EMBO J. 1994 Sep 15;13(18):4241-50 [7925269] Mol Endocrinol. 1994 Sep;8(9):1262-77 [7838159] Mol Cell Endocrinol. 1995 Mar;109(1):105-11 [7540569] Endocrinology. 1999 Apr;140(4):1665-71 [10098501] Nature. 1999 Apr 1;398(6726):422-6 [10201372] Cancer Res. 1999 Apr 15;59(8):1811-5 [10213482] Mol Carcinog. 1999 Sep;26(1):53-61 [10487522] Endocr Rev. 2004 Dec;25(6):869-98 [15583021] Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Mol Endocrinol. 2005 Jan;19(1):102-12 [15388791] Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16251-6 [16260719] Cell. 2006 Jan 27;124(2):381-92 [16439211] Int J Cancer. 2006 Apr 1;118(7):1653-9 [16231318] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1780-5 [16446424] Oncogene. 2006 May 4;25(19):2736-47 [16314832] Oncogene. 2006 Jun 15;25(25):3576-88 [16434963] Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14104-9 [16966610] Cell. 2006 Oct 6;127(1):185-97 [17018285] J Clin Invest. 2006 Nov;116(11):2972-84 [17039256] Curr Opin Genet Dev. 2007 Feb;17(1):45-51 [17208432] J Biol Chem. 2007 Apr 13;282(15):11221-9 [17287208] Carcinogenesis. 2007 May;28(5):932-9 [17127711] Prostate. 2008 Jul 1;68(10):1133-42 [18454446] Mol Cell Biol. 2008 Jul;28(14):4598-608 [18474620] Endocrinology. 2008 Aug;149(8):3817-31 [18467449] Endocr Relat Cancer. 2008 Sep;15(3):721-43 [18753362] Mol Cell Endocrinol. 2000 Jan 25;159(1-2):109-24 [10687857] Cancer Lett. 2000 Jul 31;155(2):145-52 [10822129] Science. 2000 Aug 25;289(5483):1357-60 [10958784] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3998-4003 [11274423] Mol Cell Biol. 2007 Sep;27(17):6116-26 [17606624] Mol Cell. 2007 Sep 7;27(5):691-700 [17803935] Carcinogenesis. 2007 Dec;28(12):2451-8 [17660507] Anticancer Res. 2007 Nov-Dec;27(6B):3999-4009 [18225562] Cancer Res. 2008 Mar 15;68(6):1697-706 [18339849] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/iub.180 ER - TY - JOUR T1 - Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease. AN - 67165732; 19389504 AB - Mouse models for hepatocellular carcinoma (HCC) provide an experimental ground for dissecting the genetic and biological complexities of human liver cancer and contribute to our ability to gain insights into the relevance of candidate cancer genes. We examined, using spectral karyotyping (SKY) and array-based CGH (aCGH), seven cell lines derived from HCC spontaneously developed in transgenic Myc mice (Myc), and four cell lines established from tumors induced in nude mice by inoculation with the original Myc cells (nuMyc). All the cell lines exhibited gain of material from chromosomes 5, 6, 8, 10, 11, 15, and 19 and DNA copy-number loss from chromosomes 2, 4, 7, 9, 12, 14, and X. In addition, several recurrent chromosome reorganizations were found, including del(3), t(3;8), del(4), t(4;11), t(6;5), del(7), del(8), del(9), t(10;14), del(11), and del(16). Chromosome breakpoints underlying rearrangements clustered in the regions previously identified as important for the early stages of Myc-induced hepatocarcinogenesis. The results strongly suggest the importance of recurrent breakage and loss of chromosomes 4, 9, and 14 and gain of chromosomes 15 and 19 in mouse liver neoplasia. Genomic changes observed in Myc HCC cell lines are also recurrent in HCC developed in other transgenic mouse models, in mouse spontaneous HCC and derivative cell lines, and in preneoplastic liver lesions induced with chemical carcinogens. Overall, the present results document selective, nonrandom genomic changes involving chromosomal regions homologous to those implicated in human HCC. JF - Cancer genetics and cytogenetics AU - Zimonjic, Drazen B AU - Ullmannova-Benson, Veronika AU - Factor, Valentina M AU - Thorgeirsson, Snorri S AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, 37 Convent Drive MSC 4262, Building 37, Room 4128B, Bethesda, MD 20892, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 17 EP - 26 VL - 191 IS - 1 KW - DNA, Neoplasm KW - 0 KW - Proto-Oncogene Proteins c-myc KW - Index Medicus KW - Animals KW - Comparative Genomic Hybridization KW - Chromosomes, Mammalian -- genetics KW - Humans KW - Injections, Subcutaneous KW - Gene Rearrangement KW - Disease Models, Animal KW - Mice KW - Cell Line, Tumor KW - Mice, Transgenic KW - Spectral Karyotyping KW - Liver Neoplasms -- pathology KW - Carcinoma, Hepatocellular -- genetics KW - Chromosome Aberrations KW - Carcinoma, Hepatocellular -- pathology KW - Proto-Oncogene Proteins c-myc -- genetics KW - DNA, Neoplasm -- genetics KW - Proto-Oncogene Proteins c-myc -- metabolism KW - Gene Dosage KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67165732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+genetics+and+cytogenetics&rft.atitle=Recurrent+and+nonrandom+DNA+copy+number+and+chromosome+alterations+in+Myc+transgenic+mouse+model+for+hepatocellular+carcinogenesis%3A+implications+for+human+disease.&rft.au=Zimonjic%2C+Drazen+B%3BUllmannova-Benson%2C+Veronika%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S%3BPopescu%2C+Nicholas+C&rft.aulast=Zimonjic&rft.aufirst=Drazen&rft.date=2009-05-01&rft.volume=191&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Cancer+genetics+and+cytogenetics&rft.issn=1873-4456&rft_id=info:doi/10.1016%2Fj.cancergencyto.2008.12.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-05 N1 - Date created - 2009-04-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 1999 Nov;20(11):2083-8 [10545409] Genes Dev. 2008 Jun 1;22(11):1439-44 [18519636] Cancer Res. 2000 Feb 15;60(4):1049-53 [10706123] Cytogenet Cell Genet. 2000;89(1-2):129-32 [10894954] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13306-11 [11087871] Genomics. 2001 Apr 1;73(1):20-7 [11352562] Cytogenet Cell Genet. 2001;93(1-2):114-6 [11474192] Nat Rev Cancer. 2001 Dec;1(3):214-21 [11902576] Oncogene. 2002 Feb 28;21(10):1518-26 [11896580] Mol Carcinog. 2002 May;34(1):19-24 [12112319] Nat Genet. 2002 Aug;31(4):339-46 [12149612] J Cell Mol Med. 2002 Apr-Jun;6(2):151-9 [12169201] Cytogenet Genome Res. 2002;97(1-2):140G [12438760] Lancet Oncol. 2003 Oct;4(10):639-42 [14554243] Genes Chromosomes Cancer. 2003 Dec;38(4):307-21 [14566849] Lancet Oncol. 2004 Feb;5(2):77; discussion 77 [14761808] J Cell Sci. 1977 Apr;24:217-54 [893544] Adv Cancer Res. 1986;47:235-81 [3022564] J Biol Chem. 1988 May 5;263(13):5989-92 [3283115] Carcinogenesis. 1991 Oct;12(10):1777-80 [1934257] Cancer Res. 1993 Apr 15;53(8):1719-23 [8467484] Cancer Res. 1993 May 1;53(9):1990-4 [8097672] Oncogene. 1994 Feb;9(2):665-8 [8290278] Oncogene. 1994 Mar;9(3):727-37 [8108115] Genomics. 1994 Mar 1;20(1):114-5 [8020936] Carcinogenesis. 1994 Aug;15(8):1637-45 [8055644] Drug Metab Rev. 1994;26(1-2):201-8 [8082565] Genomics. 1994 Sep 1;23(1):118-24 [7829059] Mol Carcinog. 1995 May;13(1):37-43 [7766309] Ann Surg. 1995 Aug;222(2):171-8 [7639583] Cancer Genet Cytogenet. 1995 Sep;83(2):172-3 [7553591] Cancer Res. 1996 May 1;56(9):2137-42 [8616862] Genomics. 1996 Apr 15;33(2):328-9 [8660988] Am J Pathol. 1996 Aug;149(2):407-28 [8701981] Carcinogenesis. 1997 Jan;18(1):59-81 [9054591] Nat Genet. 1997 Apr;15 Spec No:417-74 [9140409] Cancer Res. 1998 Jan 1;58(1):123-34 [9426068] Gene. 1999 Jan 21;226(2):273-83 [9931502] Hepatology. 1999 Apr;29(4):1208-14 [10094966] Am J Pathol. 1999 Apr;154(4):1047-55 [10233843] Cancer Genet Cytogenet. 1999 May;111(1):37-44 [10326589] Br J Cancer. 1999 Apr;80(1-2):73-8 [10389981] Cancer Res. 2005 Nov 1;65(21):9695-704 [16266989] Cancer Genet Cytogenet. 2007 Aug;177(1):6-15 [17693185] Neoplasia. 2007 Jul;9(7):578-88 [17710161] Cell. 2000 Jan 7;100(1):57-70 [10647931] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cancergencyto.2008.12.014 ER - TY - JOUR T1 - Next generation oncology drug development: opportunities and challenges. AN - 67162952; 19390552 AB - The optimal development of novel molecularly targeted agents for the treatment of cancer requires a re-evaluation of the current drug development paradigm. Selection of patients, optimal biologic dose versus maximum tolerated dose, definition of response and clinical benefit and trial designs that address these considerations are the focus of debate in the field of early cancer therapeutics. We present a review of the opportunities and challenges facing drug development in oncology through the phases of clinical development starting with first-in-human trials. JF - Nature reviews. Clinical oncology AU - Gutierrez, Martin E AU - Kummar, Shivaani AU - Giaccone, Giuseppe AD - National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 259 EP - 265 VL - 6 IS - 5 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Medical Oncology -- methods KW - Dose-Response Relationship, Drug KW - Humans KW - Clinical Trials as Topic KW - Maximum Tolerated Dose KW - Patient Selection KW - Research Design KW - Drug Design KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67162952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Clinical+oncology&rft.atitle=Next+generation+oncology+drug+development%3A+opportunities+and+challenges.&rft.au=Gutierrez%2C+Martin+E%3BKummar%2C+Shivaani%3BGiaccone%2C+Giuseppe&rft.aulast=Gutierrez&rft.aufirst=Martin&rft.date=2009-05-01&rft.volume=6&rft.issue=5&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Clinical+oncology&rft.issn=1759-4782&rft_id=info:doi/10.1038%2Fnrclinonc.2009.38 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-29 N1 - Date created - 2009-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nrclinonc.2009.38 ER - TY - JOUR T1 - Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors. AN - 67162760; 19228996 AB - Benztropine (BZT) analogs inhibit dopamine uptake but are less effective than cocaine in producing behavioral effects predicting abuse liability. The present study compared reinforcing effects of intravenous BZT analogs with those of standard monoamine uptake inhibitors and the effects of their oral pretreatment on cocaine self-administration. Responding of rats was maintained by cocaine [0.032-1.0 mg/kg/injection (inj)] or food reinforcement under fixed-ratio five-response schedules. Maximal rates of responding were maintained by 0.32 mg/kg/inj cocaine or substituted methylphenidate, with lower rates maintained at lower and higher doses. The N-methyl BZT analog, AHN 1-055 (3alpha-[bis(4'-fluorophenyl)methoxy]-tropane), also maintained responding (0.1 mg/kg/inj), although maximal rates were less than those with cocaine. Responding was not maintained above vehicle levels by the N-allyl, AHN 2-005 (N-allyl-3alpha-[bis(4'-fluorophenyl)methoxy]-tropane), and N-butyl, JHW 007 [N-(n-butyl)-3alpha-[bis(4'-fluorophenyl)methoxy]-tropane], BZT analogs, and it was not maintained with nisoxetine or citalopram. Presession treatment with methylphenidate (3.2-32 mg/kg) dose-dependently shifted the cocaine self-administration dose-effect curve leftward, whereas nisoxetine and citalopram effects were not significant. An intermediate dose of AHN 1-055 (32 mg/kg) increased responding maintained by low cocaine doses and decreased responding maintained by higher doses. A higher dose of AHN 1-055 completely suppressed cocaine-maintained responding. Both AHN 2-005 and JHW 007 dose-dependently (10-32 mg/kg) decreased cocaine self-administration, shifting its dose-effect curve down. Decreases in cocaine-maintained responding occurred at doses of methylphenidate and BZT analogs that left food-maintained responding unchanged. During a component in which injections were not available, methylphenidate and AHN 1-055, but not AHN 2-005 or JHW 007, increased response rates. These findings further support the low abuse liability of BZT analogs and their potential development as medications for cocaine abuse. JF - The Journal of pharmacology and experimental therapeutics AU - Hiranita, Takato AU - Soto, Paul L AU - Newman, Amy H AU - Katz, Jonathan L AD - Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 677 EP - 686 VL - 329 IS - 2 KW - Dopamine Uptake Inhibitors KW - 0 KW - Benztropine KW - 1NHL2J4X8K KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Self Administration KW - Dose-Response Relationship, Drug KW - Cocaine-Related Disorders -- psychology KW - Male KW - Cocaine-Related Disorders -- prevention & control KW - Benztropine -- administration & dosage KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Reinforcement (Psychology) KW - Benztropine -- analogs & derivatives KW - Benztropine -- pharmacology KW - Cocaine -- administration & dosage KW - Dopamine Uptake Inhibitors -- chemistry KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67162760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Assessment+of+reinforcing+effects+of+benztropine+analogs+and+their+effects+on+cocaine+self-administration+in+rats%3A+comparisons+with+monoamine+uptake+inhibitors.&rft.au=Hiranita%2C+Takato%3BSoto%2C+Paul+L%3BNewman%2C+Amy+H%3BKatz%2C+Jonathan+L&rft.aulast=Hiranita&rft.aufirst=Takato&rft.date=2009-05-01&rft.volume=329&rft.issue=2&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.145813 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-22 N1 - Date created - 2009-04-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addict Behav. 2004 Sep;29(7):1439-64 [15345275] J Pharmacol Exp Ther. 2004 Jun;309(3):959-69 [14982963] Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):67-75 [684280] Pharmacol Biochem Behav. 1987 Apr;26(4):835-9 [3496618] Science. 1987 Sep 4;237(4819):1219-23 [2820058] J Pharmacol Exp Ther. 1989 Oct;251(1):142-9 [2795456] J Pharmacol Exp Ther. 1989 Oct;251(1):150-5 [2529365] Pharmacol Biochem Behav. 1992 Dec;43(4):1135-42 [1475296] Eur J Pharmacol. 1993 Jan 12;230(2):195-201 [8422901] Drug Alcohol Depend. 1993 Jun;33(1):31-9 [8370338] J Med Chem. 1995 Sep 29;38(20):3933-40 [7562926] J Pharmacol Exp Ther. 1995 Dec;275(3):1551-9 [8531128] Life Sci. 1996;58(12):231-9 [8786705] Neuropsychopharmacology. 1996 Jun;14(6):375-424 [8726752] J Med Chem. 1997 Dec 19;40(26):4329-39 [9435902] Synapse. 1998 Sep;30(1):49-55 [9704880] J Pharmacol Exp Ther. 1999 Jan;288(1):302-15 [9862785] J Med Chem. 2004 Dec 2;47(25):6401-9 [15566309] J Neurosci. 2005 Feb 23;25(8):1889-93 [15728828] J Pharmacol Exp Ther. 2005 May;313(2):613-20 [15681658] J Pharmacol Exp Ther. 2005 Jun;313(3):1223-30 [15743929] J Pharmacol Exp Ther. 2005 Oct;315(1):397-404 [16014753] Pharmacol Ther. 2005 Oct;108(1):94-108 [16083966] Neuropsychopharmacology. 2006 Feb;31(2):351-62 [15957006] Eur J Pharmacol. 2006 Dec 28;553(1-3):149-56 [17067572] J Pharmacol Exp Ther. 2007 Jan;320(1):344-53 [17003230] J Pharmacol Exp Ther. 2007 Feb;320(2):757-65 [17105829] Pharmacol Biochem Behav. 2007 Jan;86(1):45-54 [17258302] Mol Pharmacol. 2008 Mar;73(3):813-23 [17978168] Pharmacol Biochem Behav. 2008 Sep;90(3):453-62 [18468667] Nat Neurosci. 2008 Jul;11(7):780-9 [18568020] J Pharmacol Exp Ther. 2000 Feb;292(2):521-9 [10640288] Psychopharmacology (Berl). 2000 Jan;147(4):426-35 [10672637] Psychopharmacology (Berl). 2000 Nov;152(4):414-21 [11140334] Psychopharmacology (Berl). 2001 Apr;154(4):375-82 [11349390] Psychopharmacology (Berl). 2002 Mar;160(3):263-70 [11889495] J Pharmacol Exp Ther. 2002 Oct;303(1):211-7 [12235253] J Pharmacol Exp Ther. 2003 Nov;307(2):801-8 [12966155] J Pharmacol Exp Ther. 2004 May;309(2):650-60 [14755006] Neuropharmacology. 2004;47 Suppl 1:256-73 [15464142] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.145813 ER - TY - JOUR T1 - Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. AN - 67162173; 19197004 AB - Modafinil is prescribed for numerous medical conditions, but the drug's mechanism of action is unclear. Here, we examined the interaction of modafinil with receptors and transporters in vitro and compared pharmacological effects of the drug with those produced by indirect dopamine (DA) agonists 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR12909) and (+)-methamphetamine (METH). Modafinil was screened at various receptors and transporters using binding assays. Transporter-mediated uptake and release were examined in rat brain synaptosomes. Effects of modafinil on motor activity and neurochemistry were determined in rats undergoing in vivo microdialysis in nucleus accumbens. Of the receptors and transporters assayed, modafinil displayed measurable potency only at DA transporters (DAT), inhibiting [(3)H]DA uptake, with an IC(50) value of 4.0 microM. Accordingly, modafinil pretreatment (10 microM) antagonized METH-induced release of the DAT substrate [(3)H]1-methyl-4-phenylpyridinium. Intravenous modafinil (20 and 60 mg/kg) produced dose-dependent increases in motor activity and extracellular DA, without affecting serotonin (5-HT). Analogous results were observed for GBR12909 (1 and 3 mg/kg), whereas METH (0.3 and 1 mg/kg) increased DA and 5-HT. Locomotor effects of all drugs were positively correlated with dialysate DA (P < 0.001). Interestingly, modafinil pretreatment reduced METH-induced ambulation and DA release. Our data show that modafinil interacts with DAT sites in rat brain, a property shared with agonist medications under investigation for treating cocaine dependence. Nondopaminergic mechanisms may also contribute to the pharmacology of modafinil. Finally, the results suggest that modafinil should be tested as an adjunct for treating METH addiction. JF - The Journal of pharmacology and experimental therapeutics AU - Zolkowska, Dorota AU - Jain, Raka AU - Rothman, Richard B AU - Partilla, John S AU - Roth, Bryan L AU - Setola, Vincent AU - Prisinzano, Thomas E AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 738 EP - 746 VL - 329 IS - 2 KW - Benzhydryl Compounds KW - 0 KW - Central Nervous System Stimulants KW - Dopamine Agonists KW - Dopamine Plasma Membrane Transport Proteins KW - Methamphetamine KW - 44RAL3456C KW - modafinil KW - R3UK8X3U3D KW - Index Medicus KW - Amphetamine-Related Disorders -- prevention & control KW - Animals KW - Amphetamine-Related Disorders -- metabolism KW - Synaptosomes -- drug effects KW - Dose-Response Relationship, Drug KW - Nucleus Accumbens -- drug effects KW - Radioligand Assay KW - Protein Binding KW - Binding Sites KW - Rats KW - Microdialysis KW - Rats, Sprague-Dawley KW - Dopamine Agonists -- pharmacology KW - Methamphetamine -- pharmacology KW - Nucleus Accumbens -- metabolism KW - Motor Activity -- drug effects KW - Synaptosomes -- metabolism KW - Male KW - Behavior, Animal -- drug effects KW - Central Nervous System Stimulants -- pharmacology KW - Benzhydryl Compounds -- pharmacology KW - Dopamine Plasma Membrane Transport Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67162173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Evidence+for+the+involvement+of+dopamine+transporters+in+behavioral+stimulant+effects+of+modafinil.&rft.au=Zolkowska%2C+Dorota%3BJain%2C+Raka%3BRothman%2C+Richard+B%3BPartilla%2C+John+S%3BRoth%2C+Bryan+L%3BSetola%2C+Vincent%3BPrisinzano%2C+Thomas+E%3BBaumann%2C+Michael+H&rft.aulast=Zolkowska&rft.aufirst=Dorota&rft.date=2009-05-01&rft.volume=329&rft.issue=2&rft.spage=738&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.146142 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-22 N1 - Date created - 2009-04-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Psychiatry. 2006 Jan;67(1):137-47 [16426100] J Biol Chem. 2005 Feb 18;280(7):5129-32 [15590622] Psychopharmacology (Berl). 2006 Sep;188(1):119-27 [16896954] J Pharmacol Exp Ther. 2006 Nov;319(2):561-9 [16885432] Am J Drug Alcohol Abuse. 2006;32(4):577-87 [17127546] Behav Brain Res. 2007 Jan 25;176(2):353-7 [17098298] Neuropharmacology. 2007 Feb;52(2):626-33 [17070873] Eur J Pharmacol. 2007 Jul 30;568(1-3):112-23 [17477916] Biochem Pharmacol. 2008 Jan 1;75(1):2-16 [17897630] Sleep. 2007 Dec;30(12):1712-27 [18246981] Neuropsychopharmacology. 2008 Mar;33(4):761-8 [17568397] Neuropsychopharmacology. 2008 Jun;33(7):1477-502 [17712350] Pharmacol Biochem Behav. 2008 Aug;90(2):208-17 [18403002] Neuropharmacology. 2000 Aug 23;39(11):1974-83 [10963741] Synapse. 2001 Jan;39(1):32-41 [11071707] J Neurosci. 2001 Mar 1;21(5):1787-94 [11222668] Sleep Res Online. 1998;1(1):49-61 [11382857] Neuroreport. 2001 Nov 16;12(16):3533-7 [11733706] J Pharmacol Exp Ther. 2002 Jun;301(3):1190-7 [12023554] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11934-9 [12192085] Neurosci Lett. 2003 Mar 20;339(2):143-6 [12614915] Drug Alcohol Depend. 2003 May 1;70(1):29-37 [12681523] J Pharmacol Exp Ther. 2003 Oct;307(1):138-45 [12954796] Ann N Y Acad Sci. 2003 Nov;1003:328-45 [14684456] J Neurochem. 2004 May;89(4):853-64 [15140185] Pharmacol Biochem Behav. 1986 Jul;25(1):233-48 [2875470] Brain Res. 1987 Jan 20;401(2):322-30 [3815099] Eur J Pharmacol. 1990 May 3;180(1):49-58 [1973114] Prog Neurobiol. 1994 Apr;42(6):719-61 [7938546] Sleep. 1994 Aug;17(5):436-7 [7991954] J Pharmacol Exp Ther. 1994 Dec;271(3):1216-22 [7996429] J Pharmacol Exp Ther. 1994 Dec;271(3):1597-610 [7996474] Eur Neuropsychopharmacol. 1995 Dec;5(4):509-14 [8998404] Naunyn Schmiedebergs Arch Pharmacol. 1997 Nov;356(5):562-9 [9402035] Biol Psychiatry. 1997 Dec 15;42(12):1181-3 [9426889] Neurosci Lett. 1998 Sep 4;253(2):135-8 [9774168] J Neurosci. 1999 Jan 15;19(2):630-6 [9880583] Neuropsychopharmacology. 1999 Apr;20(4):346-56 [10088135] Neuropsychopharmacology. 2005 Jan;30(1):205-11 [15525998] J Clin Psychiatry. 2006 Apr;67(4):554-66 [16669720] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.146142 ER - TY - JOUR T1 - Transcriptome analysis of liver cancer: ready for the clinic? AN - 67150512; 19328580 JF - Journal of hepatology AU - Wang, Xin Wei AU - Thorgeirsson, Snorri S AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20982, USA. xw3u@nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1062 EP - 1064 VL - 50 IS - 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67150512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Transcriptome+analysis+of+liver+cancer%3A+ready+for+the+clinic%3F&rft.au=Wang%2C+Xin+Wei%3BThorgeirsson%2C+Snorri+S&rft.aulast=Wang&rft.aufirst=Xin&rft.date=2009-05-01&rft.volume=50&rft.issue=5&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2009.02.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-17 N1 - Date created - 2009-04-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hepatology. 2004 Sep;40(3):667-76 [15349906] Gut. 2001 Feb;48(2):251-9 [11156649] N Engl J Med. 2008 Nov 6;359(19):1995-2004 [18923165] Nat Med. 2008 Aug;14(8):822-7 [18641660] Hepatology. 2008 Mar;47(3):897-907 [18176954] Cancer Cell. 2006 Aug;10(2):99-111 [16904609] N Engl J Med. 2004 Dec 30;351(27):2817-26 [15591335] J Med Screen. 2003;10(4):204-9 [14738659] Nat Med. 2003 Apr;9(4):416-23 [12640447] Nat Genet. 2003 Jan;33(1):49-54 [12469122] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Cancer. 2001 Apr 15;91(8):1479-86 [11301395] Comment In: J Hepatol. 2009 Sep;51(3):595-6; author reply 596-7 [19586677] Comment On: N Engl J Med. 2008 Nov 6;359(19):1995-2004 [18923165] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jhep.2009.02.007 ER - TY - JOUR T1 - Intractable epilepsy in patients treated for childhood acute lymphocytic leukemia. AN - 67124131; 19041267 AB - In the 1970s and 80s, standard treatment for childhood acute lymphocytic leukemia (ALL) included both intrathecal methotrexate and whole-brain irradiation. During acute treatment, seizures were not uncommon. The development of intractable epilepsy years after treatment, however, has not been well described in the literature. We describe five patients who were treated for acute lymphocytic leukemia as children, who later developed intractable epilepsy. All of the patients were diagnosed with leukemia before age seven. Treatment included both whole-brain irradiation and intrathecal chemotherapy. All five received intrathecal methotrexate; in addition, two also received intrathecal cytosine arabinoside. The first seizure occurred at a mean of 7.5 years after diagnosis. Four patients have multiple seizure types, and all patients have been on multiple antiepileptic drugs. All five patients are cognitively impaired. Successful treatment for childhood leukemia may be followed by signs of late cerebral injury including intractable epilepsy. We propose that neurotoxicity resulting from exposure to intrathecal methotrexate and cranial irradiation may have contributed to the intractable epilepsy seen in our five patients. JF - Seizure AU - Fasano, Rebecca E AU - Bergen, Donna C AD - Department of Neurological Sciences, Rush University Medical Center, 1725 W. Harrison St., Chicago, IL 60612, USA. fasanore@ninds.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 298 EP - 302 VL - 18 IS - 4 SN - 1059-1311, 1059-1311 KW - Antirheumatic Agents KW - 0 KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Humans KW - Brain -- radiation effects KW - Adult KW - Male KW - Female KW - Methotrexate -- adverse effects KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- pathology KW - Cranial Irradiation -- adverse effects KW - Antirheumatic Agents -- adverse effects KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- therapy KW - Cranial Irradiation -- methods KW - Epilepsy -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67124131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seizure&rft.atitle=Intractable+epilepsy+in+patients+treated+for+childhood+acute+lymphocytic+leukemia.&rft.au=Fasano%2C+Rebecca+E%3BBergen%2C+Donna+C&rft.aulast=Fasano&rft.aufirst=Rebecca&rft.date=2009-05-01&rft.volume=18&rft.issue=4&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Seizure&rft.issn=10591311&rft_id=info:doi/10.1016%2Fj.seizure.2008.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-09 N1 - Date created - 2009-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.seizure.2008.10.008 ER - TY - JOUR T1 - The implications of medication development in the treatment of substance use disorders in developing countries. AN - 67122756; 19346946 AB - To enquire as to how applicable are the latest developments in pharmacotherapy of substance use disorders (SUDs) to patients in developing countries. We review the latest literature regarding the magnitude of the problem in developing countries. We then present a review of recent developments in pharmacotherapy of SUDs, especially from developing countries. Finally, we discuss the barriers that prevent patients in developing countries from benefiting from these developments. The problem of SUDs is increasing in developing countries and there is a severe shortage of manpower to manage it. Disulfiram, naltrexone and acamprosate are useful in treating alcohol dependence, and likewise methadone and buprenorphine in treating opioid dependence. Strategies of matching patients to medications and combining the medications have shown promise. There is a parallel benefit of reduction in the risk of HIV spread among injecting drug users. However, many barriers prevent an average patient with SUD from benefiting from these developments. Medication treatment can improve the outcome of SUDs. Research in this field is catching up in developing countries. However, due to issues of availability, affordability, manpower and governmental policies, a large number of patients in these countries are unable to benefit from recent developments. Urgent efforts are required to fill this gap between research and practice. JF - Current opinion in psychiatry AU - Thirthalli, Jagadisha AU - Chand, Prabhat K AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India. jaga@nimhans.kar.nic.in Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 274 EP - 280 VL - 22 IS - 3 KW - Alcohol Deterrents KW - 0 KW - Narcotic Antagonists KW - Taurine KW - 1EQV5MLY3D KW - Buprenorphine KW - 40D3SCR4GZ KW - acamprosate KW - N4K14YGM3J KW - Disulfiram KW - TR3MLJ1UAI KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Alcoholism -- rehabilitation KW - Taurine -- analogs & derivatives KW - Disulfiram -- therapeutic use KW - Substance Abuse, Intravenous -- rehabilitation KW - Humans KW - Taurine -- therapeutic use KW - Substance Abuse, Intravenous -- epidemiology KW - Public Policy KW - HIV Infections -- epidemiology KW - Comorbidity KW - Alcohol Deterrents -- therapeutic use KW - Prevalence KW - Developing Countries -- statistics & numerical data KW - Methadone -- therapeutic use KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67122756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+psychiatry&rft.atitle=The+implications+of+medication+development+in+the+treatment+of+substance+use+disorders+in+developing+countries.&rft.au=Thirthalli%2C+Jagadisha%3BChand%2C+Prabhat+K&rft.aulast=Thirthalli&rft.aufirst=Jagadisha&rft.date=2009-05-01&rft.volume=22&rft.issue=3&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+psychiatry&rft.issn=1473-6578&rft_id=info:doi/10.1097%2FYCO.0b013e32832a1dc0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-14 N1 - Date created - 2009-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/YCO.0b013e32832a1dc0 ER - TY - JOUR T1 - Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1. AN - 67119959; 18656336 AB - The modulatory influence of tea polyphenols (epigallocatechin gallate, epicatechin gallate and theaflavin) on benzo[a]pyrene (B[a]P)-induced lung carcinogenesis in mice was analyzed using histopathological and molecular parameters. Progression of lung lesions was restricted at the hyperplastic stage by tea polyphenols. A significant reduction in cellular proliferative index and an increase in apoptotic index were noted in the restricted lung lesions. High expression of H-ras, c-myc, cyclin D1 and p53 genes was seen at the inflammatory stage (9th week) and in subsequent premalignant lesions, but down-regulation of H-ras at the hyperplastic stage (17th week). Expression of bcl-2 was high in hyperplastic lesions, whereas the expression of mdm2 and bcl-xl increased only at the moderately dysplastic stage (36th week). The tea polyphenols inhibited inflammatory response in the lung lesions on the 9th week, when decreased expression of H-ras and c-myc and increased expression of bax were noted. Prolonged treatment (>9th week) with tea polyphenols resulted in changes in the expression of some additional genes, such as reduced expression of cyclin D1 (from the 17th week), bcl-2 (from the 26th week; mild dysplasia) and p21 (on the 36th week), and high expression of p53 (from the 17th week) and p27 (on the 36th week). These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points. JF - The Journal of nutritional biochemistry AU - Manna, Sugata AU - Mukherjee, Sudeshna AU - Roy, Anup AU - Das, Sukta AU - Panda, Chinmay Kr AD - Department of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata 700026, India. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 337 EP - 349 VL - 20 IS - 5 KW - Biflavonoids KW - 0 KW - Flavonoids KW - Phenols KW - Polyphenols KW - Proto-Oncogene Proteins c-myc KW - Tea KW - Tumor Suppressor Protein p53 KW - Cyclin D1 KW - 136601-57-5 KW - theaflavin KW - 1IA46M0D13 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Catechin KW - 8R1V1STN48 KW - epicatechin gallate KW - 92587OVD8Z KW - epigallocatechin gallate KW - BQM438CTEL KW - ras Proteins KW - EC 3.6.5.2 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Cell Transformation, Neoplastic -- pathology KW - Catechin -- analogs & derivatives KW - Biflavonoids -- pharmacology KW - Mice KW - Lung -- pathology KW - Tumor Suppressor Protein p53 -- metabolism KW - Apoptosis -- drug effects KW - Catechin -- pharmacology KW - Female KW - Male KW - Proto-Oncogene Proteins c-myc -- biosynthesis KW - Phenols -- pharmacology KW - ras Proteins -- biosynthesis KW - Cyclin D1 -- biosynthesis KW - Lung Neoplasms -- chemically induced KW - Flavonoids -- pharmacology KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67119959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutritional+biochemistry&rft.atitle=Tea+polyphenols+can+restrict+benzo%5Ba%5Dpyrene-induced+lung+carcinogenesis+by+altered+expression+of+p53-associated+genes+and+H-ras%2C+c-myc+and+cyclin+D1.&rft.au=Manna%2C+Sugata%3BMukherjee%2C+Sudeshna%3BRoy%2C+Anup%3BDas%2C+Sukta%3BPanda%2C+Chinmay+Kr&rft.aulast=Manna&rft.aufirst=Sugata&rft.date=2009-05-01&rft.volume=20&rft.issue=5&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutritional+biochemistry&rft.issn=1873-4847&rft_id=info:doi/10.1016%2Fj.jnutbio.2008.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-25 N1 - Date created - 2009-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jnutbio.2008.04.001 ER - TY - JOUR T1 - Third generation triplet cytotoxic chemotherapy in advanced non-small cell lung cancer: a systematic overview. AN - 67113223; 18809226 AB - Previous meta-analysis on three drugs combination for treatment of advanced non-small cell lung cancer (NSCLC) did not demonstrate an improvement in survival, however many of the trials included in this meta-analysis used older and less effective cytotoxic drugs. We conducted this analysis to compare the relative efficacy of third generation triplet therapy with that of standard double therapy in the treatment of advanced NSCLC. A MEDLINE search was performed using the search terms "lung cancer" and "randomized trials". Trials not utilizing a third generation cytotoxic chemotherapeutic agent (paclitaxel, docetaxel, vinorelbine, gemcitabine) were excluded. Pooled odds ratios (OR) for the objective response and toxicity rates were calculated using the Mantel-Haenszel estimate. Pooled median ratios for median survival were calculated using the weighted sum of the log-ratio of median ratios of individual study. We analyzed six randomized comparative trials involving 1932 patients. Patients receiving triplet therapy had a significantly higher response rate (OR: 1.33; 95% CI, 1.50-2.23; P<0.001). Incidence of grade III/IV hematological toxicity was higher with triplet therapy. Non-hematological toxicities, with the exception of neuropathy, were similar. Median survival of triplet therapy was not significantly different from doublet (MR: 1.10; 95% CI: 0.91-1.35; P=0.059). Triplet therapy with third generation cytotoxic drugs is associated with higher tumor response rate at the expense of increased toxicity. Although triplet therapy had a better overall survival compared to doublet therapy, this did not reach statistical significance. JF - Lung cancer (Amsterdam, Netherlands) AU - Azim, Hatem A AU - Elattar, Inas AU - Loberiza, Fausto R AU - Azim, Hamdy AU - Mok, Tony AU - Ganti, Apar Kishor AD - Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 194 EP - 198 VL - 64 IS - 2 KW - Deoxycytidine KW - 0W860991D6 KW - Vinblastine KW - 5V9KLZ54CY KW - gemcitabine KW - B76N6SBZ8R KW - Carboplatin KW - BG3F62OND5 KW - Paclitaxel KW - P88XT4IS4D KW - Cisplatin KW - Q20Q21Q62J KW - vinorelbine KW - Q6C979R91Y KW - Ifosfamide KW - UM20QQM95Y KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Randomized Controlled Trials as Topic KW - Clinical Trials, Phase III as Topic KW - Deoxycytidine -- analogs & derivatives KW - Humans KW - Ifosfamide -- adverse effects KW - Carboplatin -- administration & dosage KW - Carboplatin -- adverse effects KW - Cisplatin -- administration & dosage KW - Vinblastine -- analogs & derivatives KW - Paclitaxel -- adverse effects KW - Deoxycytidine -- adverse effects KW - Vinblastine -- administration & dosage KW - Deoxycytidine -- administration & dosage KW - Vinblastine -- adverse effects KW - Cisplatin -- adverse effects KW - Ifosfamide -- administration & dosage KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67113223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.atitle=Third+generation+triplet+cytotoxic+chemotherapy+in+advanced+non-small+cell+lung+cancer%3A+a+systematic+overview.&rft.au=Azim%2C+Hatem+A%3BElattar%2C+Inas%3BLoberiza%2C+Fausto+R%3BAzim%2C+Hamdy%3BMok%2C+Tony%3BGanti%2C+Apar+Kishor&rft.aulast=Azim&rft.aufirst=Hatem&rft.date=2009-05-01&rft.volume=64&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.issn=1872-8332&rft_id=info:doi/10.1016%2Fj.lungcan.2008.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.lungcan.2008.08.011 ER - TY - JOUR T1 - Low weight predicts neutropenia and peginterferon alfa-2a dose reductions during treatment for chronic hepatitis C. AN - 67113205; 19220735 AB - Treatment-induced neutropenia frequently complicates the treatment course of patients treated with pegylated interferon alfa and ribavirin for chronic hepatitis C. We investigated the effect of weight on the risk for dose reductions caused by neutropenia in patients treated with a weight-independent dose of peginterferon alfa-2a. We retrospectively analysed single centre data for 172 patients enrolled in a multi-centre, open-label trial of peginterferon alfa-2a and ribavirin for chronic hepatitis C. Low body weight was significantly associated with dose reductions due to neutropenia. Patients weighing less than 62 kg had a 35% risk for significant neutropenia as opposed to a 12% risk for heavier patients (P = 0.001), and this side-effect occurred earlier during treatment. Low weight was an independent risk factor by multivariate analysis (hazard ratio 0.956/kg). The risk for treatment-induced neutropenia was associated with body surface area more than with the body mass index. In conclusion, a low pre-treatment weight strongly predicts the need for peginterferon alfa-2a dose reductions. This apparently reflects overall body size more than body fat content. It is prudent to frequently monitor blood counts for smaller-sized patients, especially during the first weeks of treatment. JF - Journal of viral hepatitis AU - Rotman, Y AU - Katz, L AU - Cohen, M AU - Cohen-Ezra, O AU - Manhaim, V AU - Braun, M AU - Ben-Ari, Z AU - Tur-Kaspa, R AD - Liver Institute, Rabin Medical Center, Bellinson Hospital, Petach-Tiqwa, Israel. rotmany@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 340 EP - 345 VL - 16 IS - 5 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2a KW - 47RRR83SK7 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Young Adult KW - Ribavirin -- therapeutic use KW - Humans KW - Body Surface Area KW - Retrospective Studies KW - Aged KW - Body Mass Index KW - Risk Factors KW - Adult KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Body Weight KW - Antiviral Agents -- therapeutic use KW - Antiviral Agents -- administration & dosage KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Interferon-alpha -- administration & dosage KW - Polyethylene Glycols -- therapeutic use KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - Neutropenia -- chemically induced KW - Polyethylene Glycols -- adverse effects KW - Antiviral Agents -- adverse effects KW - Polyethylene Glycols -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67113205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+viral+hepatitis&rft.atitle=Low+weight+predicts+neutropenia+and+peginterferon+alfa-2a+dose+reductions+during+treatment+for+chronic+hepatitis+C.&rft.au=Rotman%2C+Y%3BKatz%2C+L%3BCohen%2C+M%3BCohen-Ezra%2C+O%3BManhaim%2C+V%3BBraun%2C+M%3BBen-Ari%2C+Z%3BTur-Kaspa%2C+R&rft.aulast=Rotman&rft.aufirst=Y&rft.date=2009-05-01&rft.volume=16&rft.issue=5&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Journal+of+viral+hepatitis&rft.issn=1365-2893&rft_id=info:doi/10.1111%2Fj.1365-2893.2009.01079.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-05 N1 - Date created - 2009-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2893.2009.01079.x ER - TY - JOUR T1 - Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia. AN - 67112089; 19067193 AB - The Wnt/APC/beta-catenin signaling pathway, which includes frizzled-related protein (FRZB), plays a critical role in the development of colorectal cancer, and recent evidence suggests that the functional polymorphism, FRZB Arg324Gly, may be associated with risk for this disease. To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case-control studies. Participants consisted of 1,709 adenoma cases, 620 cancer cases, and 1,849 controls within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI) for the associations with colorectal neoplasia. No association was observed for either polymorphism or any haplotypes with colorectal adenoma or colorectal cancer (p>0.05 for all). Our study does not support the previously observed association between the FRZB 324Gly variant and colorectal cancer risk. However, further study of additional genetic variants within this pathway is still warranted, given the important role of the Wnt signaling pathway in colorectal carcinogenesis. JF - Cancer causes & control : CCC AU - Berndt, Sonja I AU - Huang, Wen-Yi AU - Yeager, Meredith AU - Weissfeld, Joel L AU - Chanock, Stephen J AU - Hayes, Richard B AD - Division of Cancer Epidemiology & Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8116, MSC 7240, Bethesda, MD 20892-7240, USA. berndts@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 487 EP - 490 VL - 20 IS - 4 KW - DNA, Neoplasm KW - 0 KW - FRZB protein KW - Glycoproteins KW - Tryptophan KW - 8DUH1N11BX KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Odds Ratio KW - Polymorphism, Single Nucleotide KW - Gene Frequency KW - Humans KW - Algorithms KW - African Americans KW - Tryptophan -- metabolism KW - DNA, Neoplasm -- isolation & purification KW - Linkage Disequilibrium KW - Sigmoidoscopy KW - Alleles KW - Haplotypes KW - European Continental Ancestry Group KW - Early Detection of Cancer KW - Amino Acid Substitution KW - Male KW - Homozygote KW - Glycine -- metabolism KW - Likelihood Functions KW - Mass Screening KW - Logistic Models KW - Risk Factors KW - Case-Control Studies KW - DNA, Neoplasm -- genetics KW - Confidence Intervals KW - Female KW - Genetic Variation KW - Colorectal Neoplasms -- pathology KW - Colorectal Neoplasms -- ethnology KW - Colorectal Neoplasms -- genetics KW - Glycoproteins -- genetics KW - Adenoma -- pathology KW - Adenoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67112089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Genetic+variants+in+frizzled-related+protein+%28FRZB%29+and+the+risk+of+colorectal+neoplasia.&rft.au=Berndt%2C+Sonja+I%3BHuang%2C+Wen-Yi%3BYeager%2C+Meredith%3BWeissfeld%2C+Joel+L%3BChanock%2C+Stephen+J%3BHayes%2C+Richard+B&rft.aulast=Berndt&rft.aufirst=Sonja&rft.date=2009-05-01&rft.volume=20&rft.issue=4&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=1573-7225&rft_id=info:doi/10.1007%2Fs10552-008-9274-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-08 N1 - Date created - 2009-04-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Nat Rev Cancer. 2001 Oct;1(1):55-67 [11900252] Hum Mol Genet. 2008 Sep 1;17(17):2665-72 [18535017] Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9757-62 [15210948] Gastroenterology. 2006 Dec;131(6):1683-9 [17188959] Carcinogenesis. 2007 Sep;28(9):1914-7 [17420170] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D528-32 [14681474] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10552-008-9274-y ER - TY - JOUR T1 - Organ preservation in locally advanced head and neck cancer of the larynx using induction chemotherapy followed by improved radiation schemes. AN - 67054086; 18779973 AB - The present prospective study seeks to evaluate overall and disease free survival, response and organ preservation rate, and toxicity of an intensive chemotherapy regimen (CT) followed by unconventional radiotherapy (RT) in patients with locally advanced operable head and neck cancer. Between January 1998 and December 2006 (June 2005), 115 patients with locally advanced, operable head and neck cancer were evaluated. A total of 333 cycles of neoadjuvant CT (cisplatin-5FU, days 1, 14, 28) followed by hyperfractionated/accelerated radiotherapy were given to 108 patients. A total of 108 patients were evaluable and received the planned CT-RT treatment. Two months after the end of RT, 97.2% of patients had a clinical complete remission of the primary and 67.5% of the neck node site. The overall survival was 55% and cause-specific survival was 73% at 5 years. Of the 33 relapsed patients, 12 recurred only at the primary site and 10 patients had distant metastases. The overall organ preservation rate was 73.5%. The chemotherapy regimen reported an overall cardiotoxicity from 5FU in 14% of patients, with severe toxicity in 3%. The radiotherapy schedule developed 84% of Grade 3-4 mucositis in the observed patients. The accelerated CT-RT regimen is able to achieve a high rate of larynx preservation, a good tolerability, and a satisfactory cause-specific overall survival. JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery AU - Franchin, Giovanni AU - Vaccher, Emanuela AU - Politi, Doriano AU - Minatel, Emilio AU - Gobitti, Carlo AU - Talamini, Renato AU - Spazzapan, Simon AU - Savignano, Maria Gabriella AU - Trovò, Mauro G AU - Barzan, Luigi AD - Department of Radiation Therapy, Centro di Riferimento Oncologico, National Cancer Institute, Via Franco Gallini 2, 33081, Aviano, Italy. gfranchin@cro.it Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 719 EP - 726 VL - 266 IS - 5 KW - Index Medicus KW - Drug Administration Schedule KW - Neoplasm Staging KW - Combined Modality Therapy KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Salvage Therapy KW - Laryngeal Neoplasms -- radiotherapy KW - Laryngeal Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Laryngeal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67054086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+archives+of+oto-rhino-laryngology+%3A+official+journal+of+the+European+Federation+of+Oto-Rhino-Laryngological+Societies+%28EUFOS%29+%3A+affiliated+with+the+German+Society+for+Oto-Rhino-Laryngology+-+Head+and+Neck+Surgery&rft.atitle=Organ+preservation+in+locally+advanced+head+and+neck+cancer+of+the+larynx+using+induction+chemotherapy+followed+by+improved+radiation+schemes.&rft.au=Franchin%2C+Giovanni%3BVaccher%2C+Emanuela%3BPoliti%2C+Doriano%3BMinatel%2C+Emilio%3BGobitti%2C+Carlo%3BTalamini%2C+Renato%3BSpazzapan%2C+Simon%3BSavignano%2C+Maria+Gabriella%3BTrov%C3%B2%2C+Mauro+G%3BBarzan%2C+Luigi&rft.aulast=Franchin&rft.aufirst=Giovanni&rft.date=2009-05-01&rft.volume=266&rft.issue=5&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=European+archives+of+oto-rhino-laryngology+%3A+official+journal+of+the+European+Federation+of+Oto-Rhino-Laryngological+Societies+%28EUFOS%29+%3A+affiliated+with+the+German+Society+for+Oto-Rhino-Laryngology+-+Head+and+Neck+Surgery&rft.issn=1434-4726&rft_id=info:doi/10.1007%2Fs00405-008-0798-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-13 N1 - Date created - 2009-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00405-008-0798-2 ER - TY - JOUR T1 - Evaluation of Digital Repository Software at the National Library of Medicine AN - 57740373; 200908077 AB - The National Institutes of Health (NIH) National Library of Medicine(Registered) (NLM) undertook an 18-month project to evaluate, test and recommend digital repository software and systems to support NLM's collection and preservation of a wide variety of digital objects. This article outlines the methodology NLM used to analyze the landscape of repository software and select three systems for in-depth testing. Finally, the article discusses the evaluation results and next steps for NLM. This project followed an earlier NLM working group, which created functional requirements and identified key policy issues for an NLM digital repository to aid in building NIM's collection in the digital environment. Adapted from the source document. JF - D-Lib Magazine AU - Marill, Jennifer L AU - Luczak, Edward C AD - National Library of Medicine jennifer.marill@nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 PB - Corporation for National Research Initiatives, Reston, VA VL - 15 IS - 5-6 SN - 1082-9873, 1082-9873 KW - Software KW - National Library of Medicine, USA KW - Institutional repositories KW - article KW - 14.19: COMPUTER APPLICATIONS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57740373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=D-Lib+Magazine&rft.atitle=Evaluation+of+Digital+Repository+Software+at+the+National+Library+of+Medicine&rft.au=Marill%2C+Jennifer+L%3BLuczak%2C+Edward+C&rft.aulast=Marill&rft.aufirst=Jennifer&rft.date=2009-05-01&rft.volume=15&rft.issue=5-6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=D-Lib+Magazine&rft.issn=10829873&rft_id=info:doi/ L2 - http://www.dlib.org LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-08-03 N1 - Last updated - 2016-09-27 N1 - CODEN - DLMAF7 N1 - SubjectsTermNotLitGenreText - Software; Institutional repositories; National Library of Medicine, USA ER - TY - JOUR T1 - Personality profiles of cultures: Patterns of ethos AN - 57309456; 200919671 AB - Culture and the human mind are deeply interdependent, because they co-evolved. Personality traits were a preexisting feature of the primate mind and must have left an imprint on forms of culture. Trait taxonomies can structure ethnographies, by specifying institutions that reflect the operation of traits. Facets of ethos can be assessed by expert ratings or objective indicators. Ratings of ethos in Japan and the US were reliable and yielded plausible descriptions of culture. However, measures of ethos based on the analysis of stories were not meaningfully correlated with aggregate personality traits or national character stereotypes. Profiles of ethos may provide another axis that can be used with aggregate personality trait levels to predict behaviour and understand the operation of culture. Published in 2009 by John Wiley & Sons, Ltd. [Copyright John Wiley and Sons, Ltd.] JF - European Journal of Personality AU - McCrae, Robert R AD - Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, USA mccraej@grc.nia.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 205 EP - 227 PB - John Wiley & Sons, Chichester UK VL - 23 IS - 3 SN - 0890-2070, 0890-2070 KW - Sons KW - Classification KW - Ethnography KW - Personality KW - Primates KW - Japan KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57309456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Personality&rft.atitle=Personality+profiles+of+cultures%3A+Patterns+of+ethos&rft.au=McCrae%2C+Robert+R&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2009-05-01&rft.volume=23&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Personality&rft.issn=08902070&rft_id=info:doi/10.1002%2Fper.712 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - EJPEEU N1 - SubjectsTermNotLitGenreText - Personality; Classification; Ethnography; Sons; Japan; Primates DO - http://dx.doi.org/10.1002/per.712 ER - TY - JOUR T1 - Brief Report: Information Processing Speed is Intact in Autism but not Correlated with Measured Intelligence AN - 57304524; 200920946 AB - Speed of information processing, as measured by inspection time (IT), is a robust predictor of intellectual functioning. However, among individuals with autism and low IQ scores, IT has been reported to be discrepantly fast, and equal to that of high IQ typically developing children (Scheuffgen et al. in Dev Psychopathol 12: 8390, 2000). The present investigation replicates and extends this study by examining IT and its relationship to IQ in a higher functioning (average range mean IQ) group of children with autism spectrum disorders (ASD) versus matched controls. Though IT was not significantly faster in the ASD group than in the matched control group, the relationship between IT and IQ was uniquely discrepant for the ASD group, partially corroborating and extending previous findings. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Wallace, Gregory L AU - Anderson, Mike AU - Happe, Francesca AD - Social, Genetic, Developmental Psychiatry Centre, Instit of Psychiatry, Kings College, U of London, UK gregwallace@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 809 EP - 814 PB - Springer, Dordrecht The Netherlands VL - 39 IS - 5 SN - 0162-3257, 0162-3257 KW - Autism, Aspergers syndrome, Processing speed, Inspection time, Intelligence, IQ KW - High functioning KW - Information processing KW - Children KW - Autistic children KW - Intelligence quotient KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57304524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Brief+Report%3A+Information+Processing+Speed+is+Intact+in+Autism+but+not+Correlated+with+Measured+Intelligence&rft.au=Wallace%2C+Gregory+L%3BAnderson%2C+Mike%3BHappe%2C+Francesca&rft.aulast=Wallace&rft.aufirst=Gregory&rft.date=2009-05-01&rft.volume=39&rft.issue=5&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-008-0684-1 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Intelligence quotient; Autistic spectrum disorders; Autistic children; Information processing; Children; High functioning DO - http://dx.doi.org/10.1007/s10803-008-0684-1 ER - TY - JOUR T1 - College Students' Motivation to Achieve and Maintain a Healthy Weight AN - 57299665; 200914735 AB - Objectives: To develop and refine a scale of motivational factors related to healthy weight achievement and maintenance and to examine differences by gender and weight status. Methods: A crosssectional survey of 300 university students aged 18-24 years. Results: Factor analysis yielded 6 factors - Intrinsic (Cronbach's alpha= 0.73): affective motivation, self-efficacy/interest; Extrinsic (Cronbach's alpha= 0.68): social reward, peer pressure, lack of choice, and authority influence. Males and normal-weight students showed higher affective motivation and overall intrinsic motivation compared to females and overweight students, (P<.001). Conclusion: Intrinsic motivational factors and gender differences should be considered in developing obesity prevention interventions in this age-group. Adapted from the source document. JF - American Journal of Health Behavior AU - Furia, Andrea C AU - Lee, Rebecca E AU - Strother, Myra L AU - Huang, Terry T-K AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, 4B11, Bethesda, MD 20892-7510 Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 256 EP - 263 PB - PNG Publications, Oak Ridge, NC VL - 33 IS - 3 SN - 1087-3244, 1087-3244 KW - weight maintenance, obesity, overweight, motivation, college students KW - Peer pressure KW - Obesity KW - Intrinsic motivation KW - Motivation KW - Gender differences KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57299665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Behavior&rft.atitle=College+Students%27+Motivation+to+Achieve+and+Maintain+a+Healthy+Weight&rft.au=Furia%2C+Andrea+C%3BLee%2C+Rebecca+E%3BStrother%2C+Myra+L%3BHuang%2C+Terry+T-K&rft.aulast=Furia&rft.aufirst=Andrea&rft.date=2009-05-01&rft.volume=33&rft.issue=3&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Behavior&rft.issn=10873244&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHBF6 N1 - SubjectsTermNotLitGenreText - Intrinsic motivation; Motivation; Gender differences; Obesity; Undergraduate students; Peer pressure ER - TY - JOUR T1 - A Randomized, Double-Blind Comparison of Lorazepam and Chlordiazepoxide in Patients with Uncomplicated Alcohol Withdrawal AN - 57281271; 200912309 AB - Objective: For important reasons, lorazepam (Ativan) and chlordiazepoxide (Librium) are both popular treatments for alcohol-withdrawal syndrome. Nevertheless, there is little literature directly comparing the two drugs. A formal comparison is desirable because of pharmacokinetic and other differences that could affect safety and efficacy considerations relevant to practice in developing countries. Method: One hundred consecutive consenting male inpatients in a state of moderately severe, uncomplicated alcohol withdrawal at screening were randomized to receive either lorazepam (8 mg/day) or chlordiazepoxide (80 mg/day) with dosing down-titrated to zero in a fixed-dose schedule across 8 treatment days. Double-blind assessments of withdrawal-symptom severity and impairing adverse events were obtained during treatment and for 4 days afterward. Results: One chlordiazepoxide patient developed withdrawal delirium. Lorazepam and chlordiazepoxide showed similar efficacy in reducing symptoms of alcohol withdrawal as assessed using the revised Clinical Institute Withdrawal Assessment for Alcohol scale. During withdrawal, irritability and dizziness were more common with lorazepam, and palpitations were more common with chlordiazepoxide. No difficulties in drug discontinuation or differences in impairing adverse events were observed with either drug. Conclusions: With the treatment schedule used in this study, lorazepam is as effective as the more traditional drug chlordiazepoxide in attenuating uncomplicated alcohol withdrawal. Lorazepam, therefore, could be used with confidence when liver disease or the inability to determine liver function status renders chlordiazepoxide therapy problematic. The absence of clinically significant withdrawal complications with lorazepam in this large study contrasts with findings from previously published studies and suggests that higher doses of lorazepam than those formerly used may be necessary during alcohol withdrawal. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Kumar, Channaveerachari Naveen AU - Andrade, Chittaranjan AU - Murthy, Pratima AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India cnkumar1974@gmail.com Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 467 EP - 474 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 70 IS - 3 SN - 1937-1888, 1937-1888 KW - Irritability KW - Clinical assessment KW - Critical incidents KW - Liver diseases KW - Efficacy KW - Withdrawal symptoms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=A+Randomized%2C+Double-Blind+Comparison+of+Lorazepam+and+Chlordiazepoxide+in+Patients+with+Uncomplicated+Alcohol+Withdrawal&rft.au=Kumar%2C+Channaveerachari+Naveen%3BAndrade%2C+Chittaranjan%3BMurthy%2C+Pratima&rft.aulast=Kumar&rft.aufirst=Channaveerachari&rft.date=2009-05-01&rft.volume=70&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Efficacy; Critical incidents; Liver diseases; Withdrawal symptoms; Clinical assessment; Irritability ER - TY - JOUR T1 - The value of vocalizing: five-month-old infants associate their own noncry vocalizations with responses from caregivers AN - 37171086; 3876583 AB - The early noncry vocalizations of infants are salient social signals. Caregivers spontaneously respond to 30%-50% of these sounds, and their responsiveness to infants' prelinguistic noncry vocalizations facilities the development of phonology and speech. Have infants learned that their vocalizations influence the behavior of social partners? If they have, infants should show an extinction burst in vocalizing when adults temporarily stop responding to infant vocalizations. Thirty-eight 5-month-olds were tested in the still-face paradigm with an unfamiliar adult. When the adult assumed a still face, infants showed an extinction burst. Thus, 5-month-olds have learned the social efficacy of their vocalizations on caregivers' behavior. Furthermore, the magnitude of 5-month infants' extinction bursts predicted their language comprehension at 13 months. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Goldstein, Michael H AU - Schwade, Jennifer A AU - Bornstein, Marc H AD - Cornell University ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 636 EP - 644 VL - 80 IS - 3 SN - 0009-3920, 0009-3920 KW - Sociology KW - Sound KW - Cognitive development KW - Phonology KW - Language acquisition KW - Speech KW - Child care KW - Child development KW - Family studies KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37171086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=The+value+of+vocalizing%3A+five-month-old+infants+associate+their+own+noncry+vocalizations+with+responses+from+caregivers&rft.au=Goldstein%2C+Michael+H%3BSchwade%2C+Jennifer+A%3BBornstein%2C+Marc+H&rft.aulast=Goldstein&rft.aufirst=Michael&rft.date=2009-05-01&rft.volume=80&rft.issue=3&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2197 2212 6075 3483; 2192; 12079 11505 1678; 12115; 7227 7239 7226; 9495 7443; 6495 2212; 2450 6075 3483; 4783 ER - TY - JOUR T1 - Early family and child-care antecedents of awakening cortisol levels in adolescence AN - 37169419; 3876601 JF - Child development AU - Roisman, Glenn I AU - Susman, Elizabeth AU - Barnett-Walker, Kortnee AU - Booth-LaForce, Cathryn AU - Owen, Margaret Tresch AU - Belsky, Jay AU - Bradley, Robert H AU - Houts, Renate AU - Steinberg, Laurence Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 907 EP - 920 VL - 80 IS - 3 SN - 0009-3920, 0009-3920 KW - Sociology KW - Demography KW - Cognitive development KW - Child care KW - Child development KW - Adolescents KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37169419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Early+family+and+child-care+antecedents+of+awakening+cortisol+levels+in+adolescence&rft.au=Roisman%2C+Glenn+I%3BSusman%2C+Elizabeth%3BBarnett-Walker%2C+Kortnee%3BBooth-LaForce%2C+Cathryn%3BOwen%2C+Margaret+Tresch%3BBelsky%2C+Jay%3BBradley%2C+Robert+H%3BHouts%2C+Renate%3BSteinberg%2C+Laurence&rft.aulast=Roisman&rft.aufirst=Glenn&rft.date=2009-05-01&rft.volume=80&rft.issue=3&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2197 2212 6075 3483; 2192; 593; 3412; 2450 6075 3483; 4783 ER - TY - JOUR T1 - The acquisition of gender labels in infancy: implications for gender-typed play AN - 37156990; 3876551 AB - Two aspects of children's early gender development-the spontaneous production of gender labels and gender-typed play-were examined longitudinally in a sample of 82 children. Survival analysis, a statistical technique well suited to questions involving developmental transitions, was used to investigate the timing of the onset of children's gender labeling as based on mothers' biweekly telephone interviews regarding their children's language from 9 through 21 months. Videotapes of children's play both alone and with mother during home visits at 17 and 21 months were independently analyzed for play with gender-stereotyped and gender-neutral toys. Finally, the relation between gender labeling and gender-typed play was examined. Children transitioned to using gender labels at approximately 19 months, on average. Although girls and boys showed similar patterns in the development of gender labeling, girls began labeling significantly earlier than boys. Modest sex differences in play were present at 17 months and increased at 21 months. Gender labeling predicted increases in gender-typed play, suggesting that knowledge of gender categories might influence gender typing before the age of 2. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Zosuls, Kristina M AU - Ruble, Diane N AU - Tamis-LeMonda, Catherine S AU - Shrout, Patrick E AU - Bornstein, Marc H AU - Greulich, Faith K AD - New York University ; National Institute of Child Health and Human Development Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 688 EP - 701 VL - 45 IS - 3 SN - 0012-1649, 0012-1649 KW - Sociology KW - Longitudinal studies KW - Emotions KW - Psychology KW - Gender differentiation KW - Socialization KW - Developmental psychology KW - Gender roles KW - Language use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37156990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=The+acquisition+of+gender+labels+in+infancy%3A+implications+for+gender-typed+play&rft.au=Zosuls%2C+Kristina+M%3BRuble%2C+Diane+N%3BTamis-LeMonda%2C+Catherine+S%3BShrout%2C+Patrick+E%3BBornstein%2C+Marc+H%3BGreulich%2C+Faith+K&rft.aulast=Zosuls&rft.aufirst=Kristina&rft.date=2009-05-01&rft.volume=45&rft.issue=3&rft.spage=688&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2Fa0014053 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 5428; 11977; 7239 7226; 5423 3549 2688 2449 10404; 7541 7537 971; 4196; 10404 DO - http://dx.doi.org/10.1037/a0014053 ER - TY - JOUR T1 - Factors influencing consent to HIV testing among wives of heavy drinkers in an urban slum in India AN - 37132895; 3865343 AB - The study examined the influence of socio cultural factors, perception of risk and exposure to violence on consent to HIV testing among at risk women in an urban slum. Married women chosen via a multistage probability sampling in a section of Bangalore, India, between 18 and 44 years, sexually active and considered to be at risk because of their husband's hazardous drinking were recruited for the study. Written informed consent was obtained and measures of risk behavior and violence were administered. Pretest HIV counseling was then conducted and consent for HIV testing was sought. Factors influencing refusal of and consent to HIV testing were documented. Data collected on 100 participants indicated that over half the sample (58%) refused consent for HIV testing. There were no significant differences between the groups who consented and those who refused on perception of risk and exposure to violence. Reasons women refused testing include the following: spouse/family would not allow it (40%), believed that they were not at risk or would test negative (29%) and underwent HIV testing during an earlier pregnancy (21%). Among those who consented for HIV testing, 79% did so because the testing site was easily accessible, 67% consented because testing was free and because the importance of HIV testing was understood. The findings highlight the role of social, logistic and awareness related factors in utilizing voluntary counseling and testing services by women in the slum community. They have important implications for HIV testing, particularly among at risk monogamous women. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Satyanarayana, Veena AU - Chandra, Prabha AU - Vaddiparti, Krishna AU - Benegal, Vivek AU - Cottler, Linda AD - Washington University in St. Louis ; National Institute of Mental Health and Neuro Sciences, India ; Institute of Human Behavior and Allied Sciences, India Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 615 EP - 621 VL - 21 IS - 5 SN - 0954-0121, 0954-0121 KW - Sociology KW - India KW - Community KW - Risk KW - Wives KW - Health care KW - Monogamy KW - Alcoholism KW - Women KW - Karnataka KW - HIV KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37132895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Factors+influencing+consent+to+HIV+testing+among+wives+of+heavy+drinkers+in+an+urban+slum+in+India&rft.au=Satyanarayana%2C+Veena%3BChandra%2C+Prabha%3BVaddiparti%2C+Krishna%3BBenegal%2C+Vivek%3BCottler%2C+Linda&rft.aulast=Satyanarayana&rft.aufirst=Veena&rft.date=2009-05-01&rft.volume=21&rft.issue=5&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120802385603 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 13598 5421 6091; 5703 3617 6220; 11035; 8250 7753 3237 12867; 913 561 6220; 13577 13598 5421 6091; 2603; 5790 5772; 5775 13521; 197 175 387 30 DO - http://dx.doi.org/10.1080/09540120802385603 ER - TY - JOUR T1 - Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder AN - 221164385; 19088739 AB - Two recent reports have highlighted ANK3 as a susceptibility gene for bipolar disorder (BD). We first reported association between BD and the ANK3 marker rs9804190 in a genome-wide association study (GWAS) of two independent samples (Baum et al., 2008). Subsequently, a meta-analysis of GWAS data based on samples from the US and the UK reported association with a different ANK3 marker, rs10994336 (Ferreira et al., 2008). The markers lie about 340 kb apart in the gene. Here, we test both markers in additional samples and characterize the contribution of each marker to BD risk. Our previously reported findings at rs9804190, which had been based on DNA pooling, were confirmed by individual genotyping in the National Institute of Mental Health (NIMH) waves 1-4 (P=0.05; odds ratio (OR)=1.24) and German (P=0.0006; OR=1.34) samples. This association was replicated in an independent US sample known as NIMH wave 5 (466 cases, 212 controls; P=0.017; OR=1.38). A random-effects meta-analysis of all three samples was significant (P=3 x 10(-6); OR=1.32), with no heterogeneity. Individual genotyping of rs10994336 revealed a significant association in the German sample (P=0.0001; OR=1.70), and similar ORs in the NIMH 1-4 and NIMH 5 samples that were not significant at the P<0.05 level. Meta-analysis of all three samples supported an association with rs10994336 (P=1.7 x 10(-5); OR=1.54), again with no heterogeneity. There was little linkage disequilibrium between the two markers. Further analysis suggested that each marker contributed independently to BD, with no significant marker x marker interaction. Our findings strongly support ANK3 as a BD susceptibility gene and suggest true allelic heterogeneity. JF - Molecular Psychiatry AU - Schulze, T G AU - Detera-wadleigh, S D AU - Akula, N AU - Gupta, A AU - Kassem, L AU - Steele, J AU - Pearl, J AU - Strohmaier, J AU - Breuer, R AU - Schwarz, M AU - Propping, P AU - Nöthen, M M AU - Cichon, S AU - Schumacher, J AU - Rietschel, M AU - Mcmahon, F J Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 487 EP - 91 CY - New York PB - Nature Publishing Group VL - 14 IS - 5 SN - 13594184 KW - Medical Sciences--Psychiatry And Neurology KW - ANK3 protein, human KW - Ankyrins KW - United States KW - Young Adult KW - Gene Frequency KW - Humans KW - National Institute of Mental Health (U.S.) KW - Genome-Wide Association Study -- methods KW - Linkage Disequilibrium KW - Genotype KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Germany KW - Meta-Analysis as Topic KW - Female KW - Male KW - Bipolar Disorder -- genetics KW - Genetic Predisposition to Disease KW - Polymorphism, Single Nucleotide -- genetics KW - Ankyrins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/221164385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Psychiatry&rft.atitle=Two+variants+in+Ankyrin+3+%28ANK3%29+are+independent+genetic+risk+factors+for+bipolar+disorder&rft.au=Schulze%2C+T+G%3BDetera-wadleigh%2C+S+D%3BAkula%2C+N%3BGupta%2C+A%3BKassem%2C+L%3BSteele%2C+J%3BPearl%2C+J%3BStrohmaier%2C+J%3BBreuer%2C+R%3BSchwarz%2C+M%3BPropping%2C+P%3BN%C3%B6then%2C+M+M%3BCichon%2C+S%3BSchumacher%2C+J%3BRietschel%2C+M%3BMcmahon%2C+F+J&rft.aulast=Schulze&rft.aufirst=T&rft.date=2009-05-01&rft.volume=14&rft.issue=5&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Molecular+Psychiatry&rft.issn=13594184&rft_id=info:doi/10.1038%2Fmp.2008.134 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group May 2009 N1 - Last updated - 2014-03-21 DO - http://dx.doi.org/10.1038/mp.2008.134 ER - TY - JOUR T1 - Fusobacterium nucleatum ATCC 10953 Requires Actinomyces naeslundii ATCC 43146 for Growth on Saliva in a Three-Species Community That Includes Streptococcus oralis 34 AN - 21486313; 12509919 AB - Formation of dental plaque is a developmental process involving initial and late colonizing species that form polymicrobial communities. Fusobacteria are the most numerous gram-negative bacteria in dental plaque, but they become prevalent after the initial commensal colonizers, such as streptococci and actinomyces, have established communities. The unusual ability of these bacteria to coaggregate with commensals, as well as pathogenic late colonizers, has been proposed to facilitate colonization by the latter organisms. We investigated the integration of Fusobacterium nucleatum into multispecies communities by employing two in vitro models with saliva as the sole nutritional source. In flow cell biofilms, numbers of cells were quantified using fluorescently conjugated antibodies against each species, and static biofilms were analyzed by quantitative real-time PCR (q-PCR) using species-specific primers. Unable to grow as single-species biofilms, F. nucleatum grew in two-species biofilms with Actinomyces naeslundii but not with Streptococcus oralis. However, enhanced growth of fusobacteria was observed in three-species biofilms, indicating that there was multispecies cooperation. Importantly, these community dynamics yielded an 18-fold increase in the F. nucleatum biomass between 4 h and 18 h in the flow cell inoculated with three species. q-PCR analysis of static biofilms revealed that maximum growth of the three species occurred at 24 h to 36 h. Lower numbers of cells were observed at 48 h, suggesting that saliva could not support higher cell densities as the sole nutrient. Integration of F. nucleatum into multispecies commensal communities was evident from the interdigitation of fusobacteria in coaggregates with A. naeslundii and S. oralis and from the improved growth of fusobacteria, which was dependent on the presence of A. naeslundii. JF - Applied and Environmental Microbiology AU - Periasamy, Saravanan AU - Chalmers, Natalia I AU - Du-Thumm, Laurence AU - Kolenbrander, Paul E AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, Bethesda, Maryland 20892, pkolenbrander@dir.nidrc.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 3250 EP - 3257 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 75 IS - 10 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Antibodies KW - Biofilms KW - Actinomyces naeslundii KW - A 01340:Antibiotics & Antimicrobials KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21486313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Fusobacterium+nucleatum+ATCC+10953+Requires+Actinomyces+naeslundii+ATCC+43146+for+Growth+on+Saliva+in+a+Three-Species+Community+That+Includes+Streptococcus+oralis+34&rft.au=Periasamy%2C+Saravanan%3BChalmers%2C+Natalia+I%3BDu-Thumm%2C+Laurence%3BKolenbrander%2C+Paul+E&rft.aulast=Periasamy&rft.aufirst=Saravanan&rft.date=2009-05-01&rft.volume=75&rft.issue=10&rft.spage=3250&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02901-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Biofilms; Actinomyces naeslundii DO - http://dx.doi.org/10.1128/AEM.02901-08 ER - TY - JOUR T1 - High Sensitivity and Specificity of Acid-Fast Microscopy for Diagnosis of Pulmonary Tuberculosis in an African Population with a High Prevalence of Human Immunodeficiency Virus AN - 21285842; 12511751 AB - Laboratories in low-income countries report that acid-fast microscopy is insensitive and nonspecific. We demonstrate that for a Ugandan population with high prevalences of tuberculosis and human immunodeficiency virus infection, acid-fast microscopy is highly sensitive (93.1%) and specific (100%) when performed by trained technologists in a carefully controlled manner using established techniques. JF - Journal of Clinical Microbiology AU - Shea, Yvonne R AU - Davis, JLucian AU - Huang, Laurence AU - Kovacs, Joseph A AU - Masur, Henry AU - Mulindwa, Francis AU - Opus, Sally AU - Chow, Yuenwah AU - Murray, Patrick R AD - Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland, Pmurray@cc.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1553 EP - 1555 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 47 IS - 5 SN - 0095-1137, 0095-1137 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Human immunodeficiency virus KW - Mycobacterium KW - Lung KW - Microscopy KW - Tuberculosis KW - Infection KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21285842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=High+Sensitivity+and+Specificity+of+Acid-Fast+Microscopy+for+Diagnosis+of+Pulmonary+Tuberculosis+in+an+African+Population+with+a+High+Prevalence+of+Human+Immunodeficiency+Virus&rft.au=Shea%2C+Yvonne+R%3BDavis%2C+JLucian%3BHuang%2C+Laurence%3BKovacs%2C+Joseph+A%3BMasur%2C+Henry%3BMulindwa%2C+Francis%3BOpus%2C+Sally%3BChow%2C+Yuenwah%3BMurray%2C+Patrick+R&rft.aulast=Shea&rft.aufirst=Yvonne&rft.date=2009-05-01&rft.volume=47&rft.issue=5&rft.spage=1553&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00348-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Lung; Microscopy; Tuberculosis; Infection; Mycobacterium; Human immunodeficiency virus DO - http://dx.doi.org/10.1128/JCM.00348-09 ER - TY - JOUR T1 - Immunological detection of N-formylkynurenine in oxidized proteins AN - 21187798; 10245442 AB - Reactions of tryptophan residues in proteins with radical and other oxidative species frequently lead to cleavage of the indole ring, modifying tryptophan residues into N-formylkynurenine (NFK) and kynurenine. Tryptophan modification has been detected in physiologically important proteins and has been associated with a number of human disease conditions. Modified residues have been identified through various combinations of proteomic analyses, tryptic digestion, HPLC, and mass spectrometry. Here we present a novel, immunological approach using polyclonal antiserum for detection of NFK. The specificity of our antiserum is confirmed using photooxidation and radical-mediated oxidation of proteins with and without tryptophan residues. The sensitivity of our antiserum is validated through detection of NFK in photooxidized myoglobin (two tryptophan residues) and in carbonate radical-oxidized human SOD1, which contains a single tryptophan residue. Analysis of photooxidized milk also shows that our antiserum can detect NFK residues in a mixture of proteins. Results from mass spectrometric analysis of photooxidized myoglobin samples corroborate the immunological data, detecting an increase in NFK content as the extent of photooxidation increases. JF - Free Radical Biology and Medicine AU - Ehrenshaft, Marilyn AU - de Oliveira Silva, Sueli AU - Perdivara, Irina AU - Bilski, Piotr AU - Sik, Robert H AU - Chignell, Colin F AU - Tomer, Kenneth B AU - Mason, Ronald P AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA, ehrensh1@niehs.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1260 EP - 1266 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 9 SN - 0891-5849, 0891-5849 KW - Biotechnology and Bioengineering Abstracts KW - N-formylkynurenine KW - Oxidized proteins KW - Tryptophan KW - Immunological detection KW - Antibodies KW - Superoxide dismutase KW - Myoglobin KW - Mass spectrometry KW - Free radicals KW - High-performance liquid chromatography KW - Data processing KW - Milk KW - myoglobin KW - Mass spectroscopy KW - Indole KW - Photooxidation KW - Oxidation KW - proteomics KW - carbonates KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21187798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+and+Medicine&rft.atitle=Immunological+detection+of+N-formylkynurenine+in+oxidized+proteins&rft.au=Ehrenshaft%2C+Marilyn%3Bde+Oliveira+Silva%2C+Sueli%3BPerdivara%2C+Irina%3BBilski%2C+Piotr%3BSik%2C+Robert+H%3BChignell%2C+Colin+F%3BTomer%2C+Kenneth+B%3BMason%2C+Ronald+P&rft.aulast=Ehrenshaft&rft.aufirst=Marilyn&rft.date=2009-05-01&rft.volume=46&rft.issue=9&rft.spage=1260&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+and+Medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2009.01.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Tryptophan; Milk; Data processing; Indole; Superoxide dismutase; Oxidation; Photooxidation; myoglobin; proteomics; carbonates; Mass spectroscopy DO - http://dx.doi.org/10.1016/j.freeradbiomed.2009.01.020 ER - TY - JOUR T1 - Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice AN - 21176263; 11236620 AB - Rationale: Effect of cannabinoid CB1 receptor deletion on cocaine's actions is controversial. This is partly based on findings in CB1-receptor-knockout (CB1-/-) mice with CD1 genetic background. Objectives: In the present study, we used CB1-/- mice with a C57BL/6J genetic background to further investigate the role of CB1 receptors in cocaine's action. Materials and methods: Locomotor activity was assessed using AccuScan locomotor chambers. Brain extracellular dopamine (DA) levels were measured by in vivo microdialysis and by fast-scan cyclic voltammetry in the nucleus accumbens (NAc). Results: CB1-/- mice displayed a significant reduction in basal levels of locomotion and extracellular DA, as well as in cocaine-enhanced locomotion and extracellular DA, as compared to their wild-type (CB1+/+) littermates. The reduction in basal and cocaine-enhanced DA appears to be related to a reduction in basal DA release, not to an increase in DA clearance, as indicated by fast-scan cyclic voltammetry in brain slices. Pharmacological blockade of CB1 receptors by SR141716 inhibited locomotion and NAc DA release in CB1+/+ mice. Conclusions: The present findings suggest an important role for CB1 receptors in mediating cocaine's behavioral and neurochemical effects. JF - Psychopharmacology AU - Li, Xia AU - Hoffman, Alexander F AU - Peng, Xiao-Qing AU - Lupica, Carl R AU - Gardner, Eliot L AU - Xi, Zheng-Xiong AD - Neuropsychopharmacology Section, Chemical Biology Research Branch, National Institute on Drug Abuse, Baltimore, MD, 21224, USA, zxi@intra.nida.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1 EP - 11 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 204 IS - 1 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - Microdialysis KW - Nucleus accumbens KW - Dopamine KW - Locomotion KW - Locomotor activity KW - Brain slice preparation KW - Cannabinoid CB1 receptors KW - Cocaine KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25080:Orientation, Migration and Locomotion KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21176263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Attenuation+of+basal+and+cocaine-enhanced+locomotion+and+nucleus+accumbens+dopamine+in+cannabinoid+CB1-receptor-knockout+mice&rft.au=Li%2C+Xia%3BHoffman%2C+Alexander+F%3BPeng%2C+Xiao-Qing%3BLupica%2C+Carl+R%3BGardner%2C+Eliot+L%3BXi%2C+Zheng-Xiong&rft.aulast=Li&rft.aufirst=Xia&rft.date=2009-05-01&rft.volume=204&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-008-1432-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Microdialysis; Nucleus accumbens; Dopamine; Locomotion; Locomotor activity; Brain slice preparation; Cocaine; Cannabinoid CB1 receptors DO - http://dx.doi.org/10.1007/s00213-008-1432-0 ER - TY - JOUR T1 - Subclinical Hypothyroidism after Radioiodine Exposure: Ukrainian-American Cohort Study of Thyroid Cancer and Other Thyroid Diseases after the Chornobyl Accident (1998-2000) AN - 21093251; 9315972 AB - Background: Hypothyroidism is the most common thyroid abnormality in patients treated with high doses of iodine-131 ( super(131)I). Data on risk of hypothyroidism from low to moderate super(131)I thyroid doses are limited and inconsistent. Objective: This study was conducted to quantify the risk of hypothyroidism prevalence in relation to super(131)I doses received because of the Chornobyl accident. Methods: This is a cross-sectional (1998-2000) screening study of thyroid diseases in a cohort of 11,853 individuals 4 mIU/L), including 14 with overt hypothyroidism. We found a significant, small association between super(131)I thyroid doses and prevalent hypothyroidism, with the excess odds ratio (EOR) per gray of 0.10 (95% confidence interval, 0.03-0.21). EOR per gray was higher in individuals with ATPO , 60 U/mL compared with individuals with ATPO > 60 U/mL (p < 0.001). Conclusions: This is the first study to find a significant relationship between prevalence of hypothyroidism and individual super(131)I thyroid doses due to environmental exposure. The radiation increase in hypothyroidism was small (10% per Gy) and limited largely to subclinical hypothyroidism. Prospective data are needed to evaluate the dynamics of radiation-related hypothyroidism and clarify the role of antithvroid antibodies. JF - Environmental Health Perspectives AU - Ostroumova, E AU - Brenner, A AU - Oliynyk, V AU - McConnell, R AU - Robbins, J AU - Terekhova, G AU - Zablotska, L AU - Likhtarev, I AU - Bouville, A AU - Shpak, V AU - Markov, V AU - Masnyk, I AU - Ron, E AU - Tronko, M AU - Hatch, M AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MS 7238, 6120 Executive Blvd., Bethesda, MD 20892-7238 USA, brennera@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 745 EP - 750 VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Aqualine Abstracts; Toxicology Abstracts; Risk Abstracts; Water Resources Abstracts; Health & Safety Science Abstracts; Environment Abstracts; Pollution Abstracts KW - Nuclear power plants KW - Ukraine, Chernobyl KW - Accidents KW - Hypothyroidism KW - X 24390:Radioactive Materials KW - AQ 00001:Water Resources and Supplies KW - R2 23020:Technological risks KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION KW - SW 3030:Effects of pollution KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21093251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Subclinical+Hypothyroidism+after+Radioiodine+Exposure%3A+Ukrainian-American+Cohort+Study+of+Thyroid+Cancer+and+Other+Thyroid+Diseases+after+the+Chornobyl+Accident+%281998-2000%29&rft.au=Ostroumova%2C+E%3BBrenner%2C+A%3BOliynyk%2C+V%3BMcConnell%2C+R%3BRobbins%2C+J%3BTerekhova%2C+G%3BZablotska%2C+L%3BLikhtarev%2C+I%3BBouville%2C+A%3BShpak%2C+V%3BMarkov%2C+V%3BMasnyk%2C+I%3BRon%2C+E%3BTronko%2C+M%3BHatch%2C+M&rft.aulast=Ostroumova&rft.aufirst=E&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0800184 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Hypothyroidism; Nuclear power plants; Accidents; Ukraine, Chernobyl DO - http://dx.doi.org/10.1289/ehp.0800184 ER - TY - JOUR T1 - A genetic approach for finding small RNAs regulators of genes of interest identifies RybC as regulating the DpiA-DpiB two-component system AN - 21016802; 9253001 AB - SummaryIn Escherichia coli, the largest class of small regulatory RNAs binds to the RNA chaperone Hfq and regulates the stability and-or translation of specific mRNAs. While recent studies have shown that some mRNAs could be subject to post-transcriptional regulation by sRNAs (e.g. mRNAs found by co-immunoprecipitation with Hfq), no method has yet been described to identify small RNAs that regulate them. We developed a method to easily make translational fusions of genes of interest to the lacZ reporter gene, under the control of a PBAD-inducible promoter. A multicopy plasmid library of the E. coli genome can then be used to screen for small RNAs that affect the activity of the fusion. This screening method was first applied to the dpiB gene from the dpiBA operon, which encodes a two-component signal transduction system involved in the SOS response to b-lactams. One small RNA, RybC, was found to negatively regulate the expression of dpiB. Using mutants in the dpiB-lacZ fusion and compensatory mutations in the RybC sRNA, we demonstrate that RybC directly base pairs with the dpiBA mRNA. JF - Molecular Microbiology AU - Mandin, Pierre AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 551 EP - 565 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 72 IS - 3 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Genomes KW - Translation KW - b-Lactam antibiotics KW - Plasmids KW - Promoters KW - Reporter gene KW - SOS response KW - Escherichia coli KW - Chaperones KW - Operons KW - Post-transcription KW - Mutation KW - Base pairs KW - Signal transduction KW - N 14810:Methods KW - G 07770:Bacteria KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21016802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=A+genetic+approach+for+finding+small+RNAs+regulators+of+genes+of+interest+identifies+RybC+as+regulating+the+DpiA-DpiB+two-component+system&rft.au=Mandin%2C+Pierre%3BGottesman%2C+Susan&rft.aulast=Mandin&rft.aufirst=Pierre&rft.date=2009-05-01&rft.volume=72&rft.issue=3&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2009.06665.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Translation; b-Lactam antibiotics; Plasmids; Promoters; Reporter gene; SOS response; Chaperones; Post-transcription; Operons; Mutation; Signal transduction; Base pairs; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2009.06665.x ER - TY - JOUR T1 - Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo AN - 20971826; 11068372 AB - Bacterial DNA expressing unmethylated CpG motifs binds to TLR9, thereby stimulating a broadly protective, innate immune response. Although CpG-mediated signal transduction has been studied, the scope of TLR9-dependent gene expression is incompletely understood. To resolve these issues, mice were treated with immunostimulatory CpG oligonucleotides (ODN) and splenic mRNA levels monitored from 30 min through 3 days by microarray. Through the unique application of bioinformatic analysis to these experimental data, this study is the first to describe the complex regulatory networks responsible for TLR9-mediated gene expression. Current results are the first to establish that CpG-induced stimulation of the innate immune system proceeds in multiple waves over time, and gene up-regulation is mediated by a small number of temporally activated "major inducers" and "minor inducers". An additional study of TNF knockout mice supports the conclusion that the regulatory networks identified by our bioinformatic analysis accurately identified CpG ODN-driven gene-gene interactions in vivo. Equally important, this work identifies the counter-regulatory mechanisms embedded within the signaling cascade that suppresses the proinflammatory response triggered in vivo by CpG DNA stimulation. Identifying these network interactions provides novel and global insights into the regulation of TLR9-mediated gene activation, improves our understanding of TLR-mediated host defense, and facilitates the development of interventions designed to optimize the nature and duration of the ensuing response. JF - Journal of Leukocyte Biology AU - Klaschik, S AU - Tross, D AU - Klinman, D M AD - Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Building 567, Room 205, Frederick, MD 21702, USA, klinmand@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 788 EP - 795 VL - 85 IS - 5 SN - 0741-5400, 0741-5400 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Bioinformatics KW - CpG islands KW - Data processing KW - Gene expression KW - Gene regulation KW - Immune response KW - Immunostimulation KW - Inflammation KW - Leukocytes KW - Oligonucleotides KW - Signal transduction KW - Spleen KW - TLR9 protein KW - Toll-like receptors KW - Transcription KW - Transcription activation KW - Tumor necrosis factor KW - Waves KW - J 02350:Immunology KW - G 07770:Bacteria KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20971826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Inductive+and+suppressive+networks+regulate+TLR9-dependent+gene+expression+in+vivo&rft.au=Klaschik%2C+S%3BTross%2C+D%3BKlinman%2C+D+M&rft.aulast=Klaschik&rft.aufirst=S&rft.date=2009-05-01&rft.volume=85&rft.issue=5&rft.spage=788&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Data processing; TLR9 protein; Tumor necrosis factor; Leukocytes; Transcription; Spleen; CpG islands; Oligonucleotides; Inflammation; Gene expression; Gene regulation; Immunostimulation; Waves; Bioinformatics; Immune response; Transcription activation; Toll-like receptors; Signal transduction ER - TY - JOUR T1 - Assessment of methods and analysis of outcomes for comprehensive optimization of nucleofection AN - 20838405; 11031706 JF - Genetic Vaccines and Therapy AU - Bradburne, C AU - Robertson, K AU - Thach, D AD - NIAID, NIH, DHHS, Bldg 33, Room 3W10A.6, 33 North Drive, MSC 3203 Bethesda, Maryland 20892-3203, USA Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 6 VL - 7 IS - 6 SN - 1479-0556, 1479-0556 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - nucleic acids KW - Transfection KW - Biotechnology KW - G 07880:Human Genetics KW - W 30915:Pharmaceuticals & Vaccines KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20838405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetic+Vaccines+and+Therapy&rft.atitle=Assessment+of+methods+and+analysis+of+outcomes+for+comprehensive+optimization+of+nucleofection&rft.au=Bradburne%2C+C%3BRobertson%2C+K%3BThach%2C+D&rft.aulast=Bradburne&rft.aufirst=C&rft.date=2009-05-01&rft.volume=7&rft.issue=6&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Genetic+Vaccines+and+Therapy&rft.issn=14790556&rft_id=info:doi/10.1186%2F1479-0556-7-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - nucleic acids; Transfection; Biotechnology DO - http://dx.doi.org/10.1186/1479-0556-7-6 ER - TY - JOUR T1 - Plasma Urate and Parkinson's Disease in the Atherosclerosis Risk in Communities (ARIC) Study AN - 20756928; 9300992 AB - Higher plasma urate concentration has been linked to lower risk of Parkinson's disease in men, but data are lacking on women and African Americans. The authors examined plasma urate in relation to Parkinson's disease in the biracial, population-based Atherosclerosis Risk in Communities (ARIC) cohort. Between 1987 and 1989, 15,792 participants, aged 45-64 years, were recruited from 4 US communities and have since been followed with 3 triennial visits and annual surveillance. Plasma urate was measured at visits 1 and 2, and the concentrations were highly correlated. From visit 1 through 2004, 95 potential cases of Parkinson's disease were identified from multiple sources. Odds ratios and 95% confidence intervals were calculated from multivariate logistic regression models. Plasma urate concentration was inversely associated with Parkinson's disease occurrence. The odds ratios between extreme quartiles of plasma urate were 0.4 (95% confidence interval: 0.2, 0.8) in the overall analysis, 0.3 (95% confidence interval: 0.1, 0.7) for men, and 0.4 (95% confidence interval: 0.2, 1.0) for Caucasians. Such an association was also suggested among women and African Americans but was not statistically significant because of small sample sizes. These data support the previous finding that urate may be a protective factor against Parkinson's disease. JF - American Journal of Epidemiology AU - Chen, Honglei AU - Mosley, Thomas H AU - Alonso, Alvaro AU - Huang, Xuemei Y1 - 2009/05/01/ PY - 2009 DA - 2009 May 01 SP - 1064 EP - 1069 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street VL - 169 IS - 9 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - cohort studies KW - Parkinson disease KW - uric acid KW - Data processing KW - Parkinson's disease KW - Statistical analysis KW - Arteriosclerosis KW - Models KW - Neurodegenerative diseases KW - Movement disorders KW - Risk factors KW - Regression analysis KW - Africa KW - Ethnic groups KW - Uric acid KW - N3 11028:Neuropharmacology & toxicology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20756928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Plasma+Urate+and+Parkinson%27s+Disease+in+the+Atherosclerosis+Risk+in+Communities+%28ARIC%29+Study&rft.au=Chen%2C+Honglei%3BMosley%2C+Thomas+H%3BAlonso%2C+Alvaro%3BHuang%2C+Xuemei&rft.aulast=Chen&rft.aufirst=Honglei&rft.date=2009-05-01&rft.volume=169&rft.issue=9&rft.spage=1064&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Data processing; Movement disorders; Risk factors; Parkinson's disease; Regression analysis; Statistical analysis; Arteriosclerosis; Models; Uric acid; Ethnic groups; Africa DO - http://dx.doi.org/10.1093/aje/kwp033 ER - TY - JOUR T1 - Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention Trial AN - 20629206; 9356370 AB - Epidemiological evidence suggests that obesity may be causally associated with colorectal cancer. Dopamine and the dopaminergic reward pathway have been implicated in drug and alcohol addiction as well as obesity. Polymorphisms within the D2 dopamine receptor gene (DRD2) have been shown to be associated with colorectal cancer risk. We investigated the association between DRD2 genotype at these loci and the risk of colorectal adenoma recurrence in the Polyp Prevention Trial. Odds ratios (OR) and 95% confidence intervals (CI) for risk of adenoma recurrence were calculated using unconditional logistic regression. Individuals with any, multiple (2) or advanced adenoma recurrence after 4 years were compared to those without adenoma recurrence. Variation in intake of certain dietary components according to DRD2 genotype at 3 loci (rs1799732; rs6277; rs1800497) was also investigated. The DRD2 rs1799732 CT genotype was significantly associated with all adenoma recurrence (OR: 1.30; 95% CI: 1.01, 1.69). The rs1800497 TT genotype was also associated with a significantly increased risk of advanced adenoma recurrence (OR: 2.40; 95% CI: 1.11, 5.20). The rs1799732 CT and rs1800497 TT genotypes were significantly associated with adenoma recurrence in the Polyp Prevention Trial. Increased risk of adenoma recurrence as conferred by DRD2 genotypes may be related to difference in alcohol and fat intake across genotypes. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Murphy, Gwen AU - Cross, Amanda J AU - Sansbury, Leah S AU - Bergen, Andrew AU - Laiyemo, Adeyinka O AU - Albert, Paul S AU - Wang, Zhuoqiao AU - Yu, Binbing AU - Lehman, Teresa AU - Kalidindi, Aravind AU - Modali, Rama AU - Schatzkin, Arthur AU - Lanza, Elaine AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, Bethesda, MD, murphygw@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 2148 EP - 2151 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 9 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Diets KW - Alcohol KW - polyps KW - colorectal carcinoma KW - prevention KW - obesity KW - Genotypes KW - Drugs KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20629206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Dopamine+D2+receptor+polymorphisms+and+adenoma+recurrence+in+the+Polyp+Prevention+Trial&rft.au=Murphy%2C+Gwen%3BCross%2C+Amanda+J%3BSansbury%2C+Leah+S%3BBergen%2C+Andrew%3BLaiyemo%2C+Adeyinka+O%3BAlbert%2C+Paul+S%3BWang%2C+Zhuoqiao%3BYu%2C+Binbing%3BLehman%2C+Teresa%3BKalidindi%2C+Aravind%3BModali%2C+Rama%3BSchatzkin%2C+Arthur%3BLanza%2C+Elaine&rft.aulast=Murphy&rft.aufirst=Gwen&rft.date=2009-05-01&rft.volume=124&rft.issue=9&rft.spage=2148&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Alcohol; polyps; colorectal carcinoma; obesity; prevention; Genotypes; Drugs; Cancer DO - http://dx.doi.org/10.1002/ijc.24079 ER - TY - JOUR T1 - Physical activity, sedentary behavior, and endometrial cancer risk in the NIH-AARP Diet and Health Study AN - 20627893; 9356369 AB - Consistent with a strong hormonal etiology, endometrial cancer is thought to be influenced by both obesity and physical activity. Although obesity has been consistently related to risk, associations with physical activity have been inconclusive. We examined relationships of activity patterns with endometrial cancer incidence in the NIH-AARP Diet and Health Study cohort, which included 109,621 women, ages 50-71, without cancer history, who in 1995-1996 completed a mailed baseline questionnaire capturing daily routine and vigorous (defined as any period of 20 min of activity at work or home causing increases in breathing, heart rate, or sweating) physical activity. A second questionnaire, completed by 70,351 women, in 1996-1997 collected additional physical activity information. State cancer registry linkage identified 1,052 primary incident endometrial cancers from baseline through December 31, 2003. In multivariate proportional hazards models, vigorous activity was inversely associated with endometrial cancer in a dose-response manner (p for trend = 0.02) (relative risk (RR) for 5 times/week vs. never/rarely = 0.77, 95% confidence interval (CI): 0.63-0.95); this association was more pronounced among overweight and obese women (body mass index 25; RR = 0.61, 95% CI: 0.47-0.79) than among lean women (body mass index <25; RR = 0.76, 95% CI: 0.52-1.10; p for interaction = 0.12). Although we observed no associations with light/moderate, daily routine or occupational physical activities, risk did increase with number of hours of daily sitting (p for trend = 0.02). Associations with vigorous activities, which may interact with body mass index, suggest directions for future research to clarify underlying biologic mechanisms, including those relating to hormonal alterations. JF - International Journal of Cancer AU - Gierach, Gretchen L AU - Chang, Shih-Chen AU - Brinton, Louise A AU - Lacey Jr, James V AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, gierachg@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 2139 EP - 2147 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 9 SN - 0020-7136, 0020-7136 KW - Physical Education Index; Risk Abstracts KW - Diets KW - Historical account KW - Obesity KW - Age KW - Etiology KW - Body mass KW - Women KW - obesity KW - Surveys KW - Health (behavior) KW - Exercise KW - Cancer KW - Behavior KW - body mass KW - heart rate KW - Dose-response effects KW - Diet KW - physical activity KW - Trends KW - R2 23060:Medical and environmental health KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20627893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Physical+activity%2C+sedentary+behavior%2C+and+endometrial+cancer+risk+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Gierach%2C+Gretchen+L%3BChang%2C+Shih-Chen%3BBrinton%2C+Louise+A%3BLacey+Jr%2C+James+V%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BLeitzmann%2C+Michael+F&rft.aulast=Gierach&rft.aufirst=Gretchen&rft.date=2009-05-01&rft.volume=124&rft.issue=9&rft.spage=2139&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24059 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Body mass; Women; Health (behavior); Surveys; Diet; Exercise; Trends; Cancer; Diets; Historical account; Etiology; Age; Behavior; heart rate; body mass; Dose-response effects; obesity; physical activity DO - http://dx.doi.org/10.1002/ijc.24059 ER - TY - JOUR T1 - Exposure to enriched environment restores the survival and differentiation of new born cells in the hippocampus and ameliorates depressive symptoms in chronically stressed rats AN - 20625203; 9363185 AB - Chronic stress decreases neurogenesis in the adult brain, while exposure to enriched environment (EE) increases it. Recent studies demonstrate the ability of EE to ameliorate stress-induced behavioral deficits. Whether a restored neurogenesis contributes to these effects of EE is unknown. Recently, we demonstrated that EE following restraint stress restores cell proliferation in the dentate gyrus (DG), hippocampal volume and learning. In the current study, we examine the effects of EE following stress on survival and differentiation of the progenitor cells in the DG and behavioral depression using the forced swim test (FST) and sucrose consumption test (SCT). Adult male Wistar rats were subjected to 21 days of restraint stress followed by housing in either standard or enriched conditions (10 days, 6 h/day). Survival and differentiation of BrdU-labeled cells were evaluated 31 days post-BrdU administration. Stress decreased the survival and differentiation of progenitor cells, which was ameliorated by EE. Also the percentage of BrdU- ir cells that did not co-localize with NeuN or S100 beta was significantly greater in the stressed rats and was restored by EE. Stress increased immobility in FST and decreased sucrose preference in the SCT, and these behaviors were ameliorated by EE. Adult neurogenesis is thought to be linked to learning and memory and in mediating antidepressant effect. Taken together with our earlier report that EE restores stress-induced impairment in learning and cytogenesis, the current results indicate that the reversal of adult neurogenesis could be one of the mechanisms involved in the amelioration of stress-induced deficits. JF - Neuroscience Letters AU - Veena, J AU - Srikumar, B N AU - Raju, T R AU - Rao, BSShankaranarayana AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), PB # 2900, Hosur Road, Bangalore 560 029, India, bssrao@nimhans.kar.nic.in Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 178 EP - 182 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 455 IS - 3 SN - 0304-3940, 0304-3940 KW - Animal Behavior Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Neurogenesis KW - Chronic restraint stress KW - Environmental enrichment KW - Depression KW - BrdU immunoreactivity KW - Forced swim test KW - Sucrose consumption test KW - Cell survival KW - Learning KW - S100 beta protein KW - Housing KW - Hippocampus KW - Brain KW - Stress KW - Dentate gyrus KW - Antidepressants KW - Differentiation KW - Stem cells KW - Memory KW - Nervous system KW - Sucrose KW - Cell proliferation KW - Enrichment KW - X 24310:Pharmaceuticals KW - N3 11007:Neurobiology KW - Y 25050:Genetics and Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20625203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+Letters&rft.atitle=Exposure+to+enriched+environment+restores+the+survival+and+differentiation+of+new+born+cells+in+the+hippocampus+and+ameliorates+depressive+symptoms+in+chronically+stressed+rats&rft.au=Veena%2C+J%3BSrikumar%2C+B+N%3BRaju%2C+T+R%3BRao%2C+BSShankaranarayana&rft.aulast=Veena&rft.aufirst=J&rft.date=2009-05-01&rft.volume=455&rft.issue=3&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Neuroscience+Letters&rft.issn=03043940&rft_id=info:doi/10.1016%2Fj.neulet.2009.03.059 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell survival; Learning; S100 beta protein; Depression; Housing; Hippocampus; Brain; Stress; Dentate gyrus; Differentiation; Antidepressants; Nervous system; Memory; Neurogenesis; Stem cells; Sucrose; Enrichment; Cell proliferation DO - http://dx.doi.org/10.1016/j.neulet.2009.03.059 ER - TY - JOUR T1 - Review: Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide AN - 20592629; 9303440 AB - Both major depressive disorder and bipolar disorder are the subject of a voluminous imaging and genetics literature. Here, we attempt a comprehensive review of MRI and metabolic PET studies conducted to date on these two disorders, and interpret our findings from the perspective of developmental and degenerative models of illness. Elevated activity and volume loss of the hippocampus, orbital and ventral prefrontal cortex are recurrent themes in the literature. In contrast, dorsal aspects of the PFC tend to display hypometabolism. Ventriculomegaly and white matter hyperintensities are intimately associated with depression in elderly populations and likely have a vascular origin. Important confounding influences are medication, phenotypic and genetic heterogeneity, and technological limitations. We suggest that environmental stress and genetic risk variants interact with each other in a complex manner to alter neural circuitry and precipitate illness. Imaging genetic approaches hold out promise for advancing our understanding of affective illness. JF - Neuroscience & Biobehavioral Reviews AU - Savitz, Jonathan AU - Drevets, Wayne C AD - Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH/NIMH, Bethesda, MD 20892, United States, savitzj@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 699 EP - 771 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 33 IS - 5 SN - 0149-7634, 0149-7634 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Neuroimaging KW - Hippocampus KW - Magnetic resonance imaging KW - Substantia alba KW - Nervous system KW - Positron emission tomography KW - Geriatrics KW - Environmental stress KW - Vascular system KW - Depression KW - Neural networks KW - Bipolar disorder KW - Reviews KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20592629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+%26+Biobehavioral+Reviews&rft.atitle=Review%3A+Bipolar+and+major+depressive+disorder%3A+Neuroimaging+the+developmental-degenerative+divide&rft.au=Savitz%2C+Jonathan%3BDrevets%2C+Wayne+C&rft.aulast=Savitz&rft.aufirst=Jonathan&rft.date=2009-05-01&rft.volume=33&rft.issue=5&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Neuroscience+%26+Biobehavioral+Reviews&rft.issn=01497634&rft_id=info:doi/10.1016%2Fj.neubiorev.2009.01.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Reviews; Depression; Nervous system; Neural networks; Hippocampus; Substantia alba; Cortex (prefrontal); Bipolar disorder; Environmental stress; Geriatrics; Vascular system; Positron emission tomography; Magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neubiorev.2009.01.004 ER - TY - JOUR T1 - Tumor suppressor and oncogene actions of TGF beta 1 occur early in skin carcinogenesis and are mediated by Smad3 AN - 20592219; 9306851 AB - Interactions between TGF1 and ras signaling pathways play an important role in cancer development. Here we show that in primary mouse keratinocytes, v-rasHa does not block the early biochemical events of TGF1 signal transduction but does alter global TGF1 mediated gene expression in a gene specific manner. Expression of Smad3 dependent TGF1 early response genes and the TGF1 cytostatic gene expression response were not altered by v-rasHa consistent with an intact TGF1 growth arrest. However, TGF1 and v-rasHa cause significant alteration in genes regulating matrix remodeling as the TGF1 induction of extracellular matrix genes was blocked by v-rasHa but specific matrix proteases associated with cancer progression were elevated. Smad3 deletion in keratinocytes repressed normal differentiation maker expression and caused expression of Keratin 8 a simple epithelial keratin and marker of malignant conversion. Smad3 was required for the TGF1 cytostatic response in v-rasHa keratinocytes, but also for protease induction, keratinocyte attachment and migration. These results show that pro-oncogenic activities of TGF1 can occur early in carcinogenesis before loss of its tumor suppressive function and that selective regulation rather than complete inactivation of Smad3 function may be crucial for tumor progression. JF - Molecular Carcinogenesis AU - Bae, Dong-Soon AU - Blazanin, Nicholas AU - Licata, Mathew AU - Lee, Jessica AU - Glick, Adam B AD - Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 441 EP - 453 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 5 SN - 0899-1987, 0899-1987 KW - Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - Tumor suppressor genes KW - Migration KW - Transforming growth factor-^b1 KW - Transforming growth factor-b1 KW - Leukocyte migration KW - Gene expression KW - Differentiation KW - Oncogenes KW - Proteinase KW - Keratinocytes KW - Ras protein KW - Skin KW - Tumors KW - Cancer KW - Keratin KW - Extracellular matrix KW - Carcinogenesis KW - Smad3 protein KW - Signal transduction KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - B 26610:Guanine nucleotide-binding proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20592219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Carcinogenesis&rft.atitle=Tumor+suppressor+and+oncogene+actions+of+TGF+beta+1+occur+early+in+skin+carcinogenesis+and+are+mediated+by+Smad3&rft.au=Bae%2C+Dong-Soon%3BBlazanin%2C+Nicholas%3BLicata%2C+Mathew%3BLee%2C+Jessica%3BGlick%2C+Adam+B&rft.aulast=Bae&rft.aufirst=Dong-Soon&rft.date=2009-05-01&rft.volume=48&rft.issue=5&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Molecular+Carcinogenesis&rft.issn=08991987&rft_id=info:doi/10.1002%2Fmc.20482 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Smad3 protein; Keratinocytes; Carcinogenesis; Gene expression; Tumors; Keratin; Signal transduction; Cancer; Proteinase; Oncogenes; Leukocyte migration; Transforming growth factor-b1; Ras protein; Tumor suppressor genes; Differentiation; Extracellular matrix; Skin; Migration; Transforming growth factor-^b1 DO - http://dx.doi.org/10.1002/mc.20482 ER - TY - JOUR T1 - Alcohol Use and Risk of Pancreatic Cancer AN - 20588537; 9300983 AB - The epidemiologic evidence for the role of alcohol use in pancreatic cancer development is equivocal. The authors prospectively examined the relation between alcohol use and risk of pancreatic cancer among 470,681 participants who were aged 50-71 years in 1995-1996 in the US National Institutes of Health-AARP Diet and Health Study. The authors identified 1,149 eligible exocrine pancreatic cancer cases through December 2003. Multivariate Cox proportional hazards regression models were used to calculate relative risks and 95% confidence intervals with the referent group being light drinkers (<1 drink/day). The relative risks of developing pancreatic cancer were 1.45 (95% confidence interval (CI): 1.17, 1.80; Ptrend=0.002) for heavy total alcohol use ( greater than or equal to 3 drinks/day, similar to 40 g of alcohol/day) and 1.62 (95% CI: 1.24, 2.10; Ptrend=0.001) for heavy liquor use, compared with the respective referent group. The increased risk with heavy total alcohol use was seen in never smokers (relative risk=1.35, 95% CI: 0.79, 2.30) and participants who quit smoking 10 or more years ago before baseline (relative risk=1.41, 95% CI: 1.01, 2.00). These findings suggest a moderately increased pancreatic cancer risk with heavy alcohol use, particularly liquor; however, residual confounding by cigarette smoking cannot be completely excluded. JF - American Journal of Epidemiology AU - Jiao, Li AU - Silverman, Debra T AU - Schairer, Catherine AU - Thiebaut, Anne CM AU - Hollenbeck, Albert R AU - Leitzmann, Michael F AU - Schatzkin, Arthur AU - Stolzenberg-Solomon, Rachael Z Y1 - 2009/05/01/ PY - 2009 DA - 2009 May 01 SP - 1043 EP - 1051 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street VL - 169 IS - 9 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Health & Safety Science Abstracts KW - alcohol drinking KW - cohort studies KW - pancreatic neoplasms KW - risk KW - smoking KW - Alcohol KW - Smoking KW - Age KW - Pancreatic cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Alcohol+Use+and+Risk+of+Pancreatic+Cancer&rft.au=Jiao%2C+Li%3BSilverman%2C+Debra+T%3BSchairer%2C+Catherine%3BThiebaut%2C+Anne+CM%3BHollenbeck%2C+Albert+R%3BLeitzmann%2C+Michael+F%3BSchatzkin%2C+Arthur%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Jiao&rft.aufirst=Li&rft.date=2009-05-01&rft.volume=169&rft.issue=9&rft.spage=1043&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoking; Alcohol; Age; Pancreatic cancer DO - http://dx.doi.org/10.1093/aje/kwp034 ER - TY - JOUR T1 - dCAS: a desktop application for cDNA sequence annotation AN - 20587242; 9301051 AB - Motivation: Understanding gene regulation and expression is the key to the advancement of biology. EST sequence assembly and analysis provide unique benefits in this regard. We have developed a standalone application, dCAS (Desktop cDNA Annotation System), which performs automated EST cleaning, clustering, assembly and annotation on a desktop computer. Compared with other available tools, dCAS provides a more convenient and user-friendly solution to biologists for extracting biological meaning from sequence data.Availability: The dCAS package is distributed freely. A cross-platform installer and associated sequence databases can be downloaded at: http://exon.niaid.nih.gov/applications.htmlContact: guoyoatmail.nih.gov JF - Bioinformatics AU - Guo, Yongjian AU - Ribeiro, Jose MC AU - Anderson, Jennifer M AU - Bour, Stephan AD - 1 Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology and 2 Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA Y1 - 2009/05/01/ PY - 2009 DA - 2009 May 01 SP - 1195 EP - 1196 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 25 IS - 9 SN - 1367-4803, 1367-4803 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Databases KW - Gene regulation KW - Computers KW - Bioinformatics KW - expressed sequence tags KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20587242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=dCAS%3A+a+desktop+application+for+cDNA+sequence+annotation&rft.au=Guo%2C+Yongjian%3BRibeiro%2C+Jose+MC%3BAnderson%2C+Jennifer+M%3BBour%2C+Stephan&rft.aulast=Guo&rft.aufirst=Yongjian&rft.date=2009-05-01&rft.volume=25&rft.issue=9&rft.spage=1195&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp129 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Databases; Computers; Gene regulation; Bioinformatics; expressed sequence tags DO - http://dx.doi.org/10.1093/bioinformatics/btp129 ER - TY - JOUR T1 - Exercise and the brain: something to chew on AN - 20568811; 9275953 AB - Evidence is accumulating that exercise has profound benefits for brain function. Physical activity improves learning and memory in humans and animals. Moreover, an active lifestyle might prevent or delay loss of cognitive function with aging or neurodegenerative disease. Recent research indicates that the effects of exercise on the brain can be enhanced by concurrent consumption of natural products such as omega fatty acids or plant polyphenols. The potential synergy between diet and exercise could involve common cellular pathways important for neurogenesis, cell survival, synaptic plasticity and vascular function. Optimal maintenance of brain health might depend on exercise and intake of natural products. JF - Trends in Neurosciences AU - van Praag, H AD - 251 Bayview Blvd, vanpraagh@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 283 EP - 290 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 32 IS - 5 SN - 0166-2236, 0166-2236 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Cell survival KW - Physical activity KW - Lipids KW - Aging KW - natural products KW - Health KW - Plasticity (synaptic) KW - Lifestyle KW - Neurogenesis KW - Memory KW - Vascular system KW - Diets KW - Diet (effects) KW - Learning KW - Polyphenols KW - Preventive health KW - Brain KW - Exercise KW - Physical training KW - Neurodegenerative diseases KW - Cognitive ability KW - Reviews KW - Fatty acids KW - Trends KW - N3 11001:Behavioral and Cognitive Neuroscience KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20568811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Neurosciences&rft.atitle=Exercise+and+the+brain%3A+something+to+chew+on&rft.au=van+Praag%2C+H&rft.aulast=van+Praag&rft.aufirst=H&rft.date=2009-05-01&rft.volume=32&rft.issue=5&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Trends+in+Neurosciences&rft.issn=01662236&rft_id=info:doi/10.1016%2Fj.tins.2008.12.007 LA - English DB - Physical Education Index N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Learning; Diet (effects); Preventive health; Lipids; Brain; Health; Exercise; Trends; Lifestyle; Cell survival; Diets; Polyphenols; Physical activity; Aging; natural products; Plasticity (synaptic); Physical training; Neurodegenerative diseases; Memory; Neurogenesis; Cognitive ability; Reviews; Fatty acids; Vascular system DO - http://dx.doi.org/10.1016/j.tins.2008.12.007 ER - TY - JOUR T1 - Histone H2AX is integral to hypoxia-driven neovascularization AN - 20568251; 9275840 AB - H2A histone family member X (H2AX, encoded by H2AFX) and its C- terminal phosphorylation ([gamma]-H2AX) participates in the DNA damage response and mediates DNA repair super(6). Hypoxia is a physiological stress that induces a replication-associated DNA damage response super(7). Moreover, hypoxia is the major driving force for neovascularization super(8), as the hypoxia- mediated induction of vascular growth factors triggers endothelial cell proliferation super(8). Here we studied the role of the hypoxia-induced DNA damage response in endothelial cell function and in hypoxia-driven neovascularization in vivo. Hypoxia induced replication-associated generation of [gamma]-H2AX in endothelial cells in vitro and in mice. Both in cultured cells and in mice, endothelial cell proliferation under hypoxic conditions was reduced by H2AX deficiency. Whereas developmental angiogenesis was not affected in H2afx super(-/-) mice, hypoxia-induced neovascularization during pathologic proliferative retinopathy, in response to hind limb ischemia or during tumor angiogenesis was substantially lower in H2afx super(-/-) mice. Moreover, endothelial-specific H2afx deletion resulted in reduced hypoxia-driven retina neovascularization and tumor neovascularization. Our findings establish that H2AX, and hence activation of the DNA repair response, is needed for endothelial cells to maintain their proliferation under hypoxic conditions and is crucial for hypoxia-driven neovascularization. JF - Nature Medicine AU - Economopoulou, Matina AU - Langer, Harald F AU - Celeste, Arkady AU - Orlova, Valeria V AU - Choi, Eun Young AU - Ma, Mingchao AU - Vassilopoulos, Athanassios AU - Callen, Elsa AU - Deng, Chuxia AU - Bassing, Craig H AU - Boehm, Manfred AU - Nussenzweig, Andre AU - Chavakis, Triantafyllos AD - Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland, USA., chavakist@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 553 EP - 558 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 15 IS - 5 SN - 1078-8956, 1078-8956 KW - Biochemistry Abstracts 2: Nucleic Acids; Sustainability Science Abstracts KW - Retina KW - vascularization KW - Physiology KW - Angiogenesis KW - tumors KW - Endothelial cells KW - Phosphorylation KW - Retinopathy KW - Growth factors KW - growth factors KW - Vascular system KW - Stress KW - Mice KW - Ischemia KW - Tumors KW - DNA repair KW - DNA damage KW - Limbs KW - Hypoxia KW - DNA KW - Cell proliferation KW - Histone H2A KW - M3 1010:Issues in Sustainable Development KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20568251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Histone+H2AX+is+integral+to+hypoxia-driven+neovascularization&rft.au=Economopoulou%2C+Matina%3BLanger%2C+Harald+F%3BCeleste%2C+Arkady%3BOrlova%2C+Valeria+V%3BChoi%2C+Eun+Young%3BMa%2C+Mingchao%3BVassilopoulos%2C+Athanassios%3BCallen%2C+Elsa%3BDeng%2C+Chuxia%3BBassing%2C+Craig+H%3BBoehm%2C+Manfred%3BNussenzweig%2C+Andre%3BChavakis%2C+Triantafyllos&rft.aulast=Economopoulou&rft.aufirst=Matina&rft.date=2009-05-01&rft.volume=15&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm.1947 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Retina; vascularization; Angiogenesis; Stress; Tumors; Ischemia; DNA repair; Endothelial cells; DNA damage; Limbs; Phosphorylation; Retinopathy; Hypoxia; Growth factors; Cell proliferation; Histone H2A; Vascular system; Physiology; DNA; tumors; Mice; growth factors DO - http://dx.doi.org/10.1038/nm.1947 ER - TY - JOUR T1 - A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia AN - 20567944; 9275845 AB - Organized neuronal firing is crucial for cortical processing and is disrupted in schizophrenia. Using rapid amplification of 5' complementary DNA ends in human brain, we identified a primate-specific isoform (3.1) of the ether-a-go-go-related K super(+) channel KCNH2 that modulates neuronal firing. KCNH2-3.1 messenger RNA levels are comparable to full-length KCNH2 (1A) levels in brain but three orders of magnitude lower in heart. In hippocampus from individuals with schizophrenia, KCNH2-3.1 expression is 2.5-fold greater than KCNH2-1A expression. A meta-analysis of five clinical data sets (367 families, 1,158 unrelated cases and 1,704 controls) shows association of single nucleotide polymorphisms in KCNH2 with schizophrenia. Risk-associated alleles predict lower intelligence quotient scores and speed of cognitive processing, altered memory-linked functional magnetic resonance imaging signals and increased KCNH2-3.1 mRNA levels in postmortem hippocampus. KCNH2-3.1 lacks a domain that is crucial for slow channel deactivation. Overexpression of KCNH2-3.1 in primary cortical neurons induces a rapidly deactivating K super(+) current and a high- frequency, nonadapting firing pattern. These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target. JF - Nature Medicine AU - Huffaker, Stephen J AU - Chen, Jingshan AU - Nicodemus, Kristin K AU - Sambataro, Fabio AU - Yang, Feng AU - Mattay, Venkata AU - Lipska, Barbara K AU - Hyde, Thomas M AU - Song, Jian AU - Rujescu, Dan AU - Giegling, Ina AU - Mayilyan, Karine AU - Proust, Morgan J AU - Soghoyan, Armen AU - Caforio, Grazia AU - Callicott, Joseph H AU - Bertolino, Alessandro AU - Meyer-Lindenberg, Andreas AU - Chang, Jay AU - Ji, Yuanyuan AU - Egan, Michael F AU - Goldberg, Terry E AU - Kleinman, Joel E AU - Lu, Bai AU - Weinberger, Daniel R AD - Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA., weinberd@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 509 EP - 518 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 15 IS - 5 SN - 1078-8956, 1078-8956 KW - Sustainability Science Abstracts; CSA Neurosciences Abstracts KW - Brain mapping KW - Hippocampus KW - Functional magnetic resonance imaging KW - Physiology KW - Schizophrenia KW - Mental disorders KW - Firing rate KW - Cortex KW - Information processing KW - Deactivation KW - Drugs KW - intelligence KW - Heart KW - Data processing KW - Brain KW - Firing pattern KW - mRNA KW - Channels KW - Intelligence KW - cognitive ability KW - Psychosis KW - Cognitive ability KW - Single-nucleotide polymorphism KW - Reviews KW - Computed tomography KW - DNA KW - Potassium channels KW - mental disorders KW - N3 11001:Behavioral and Cognitive Neuroscience KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20567944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=A+primate-specific%2C+brain+isoform+of+KCNH2+affects+cortical+physiology%2C+cognition%2C+neuronal+repolarization+and+risk+of+schizophrenia&rft.au=Huffaker%2C+Stephen+J%3BChen%2C+Jingshan%3BNicodemus%2C+Kristin+K%3BSambataro%2C+Fabio%3BYang%2C+Feng%3BMattay%2C+Venkata%3BLipska%2C+Barbara+K%3BHyde%2C+Thomas+M%3BSong%2C+Jian%3BRujescu%2C+Dan%3BGiegling%2C+Ina%3BMayilyan%2C+Karine%3BProust%2C+Morgan+J%3BSoghoyan%2C+Armen%3BCaforio%2C+Grazia%3BCallicott%2C+Joseph+H%3BBertolino%2C+Alessandro%3BMeyer-Lindenberg%2C+Andreas%3BChang%2C+Jay%3BJi%2C+Yuanyuan%3BEgan%2C+Michael+F%3BGoldberg%2C+Terry+E%3BKleinman%2C+Joel+E%3BLu%2C+Bai%3BWeinberger%2C+Daniel+R&rft.aulast=Huffaker&rft.aufirst=Stephen&rft.date=2009-05-01&rft.volume=15&rft.issue=5&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm.1962 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Brain mapping; Data processing; Hippocampus; Functional magnetic resonance imaging; Firing pattern; mRNA; Schizophrenia; Intelligence; Firing rate; Mental disorders; Cortex; Single-nucleotide polymorphism; Cognitive ability; Psychosis; Information processing; Reviews; Computed tomography; DNA; Deactivation; Potassium channels; Drugs; Channels; cognitive ability; Physiology; Brain; mental disorders; intelligence DO - http://dx.doi.org/10.1038/nm.1962 ER - TY - JOUR T1 - Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-xL AN - 20563496; 9273109 AB - Cancer cells evade death by over-producing specific proteins that inhibit apoptosis. One such group of proteins is the Bcl-2 family, of which Bcl-xL is an important member. This protein binds and inhibits BAK, another protein that promotes apoptosis. While the development of chemical inhibitors that block Bcl-xL-BAK association have been the focus of intense research efforts, we demonstrate in this manuscript an alternative strategy to downregulate Bcl-xL. We have identified a small molecule (Bang52) that induces apoptosis in a lymphoblast-derived cell line by lowering levels of Bcl-xL. Since Bang52 bears no resemblance to any chemical binder of Bcl-xL we believe that degradation of the protein is stimulated by a new type of pathway. These findings highlight a novel approach to the development of small molecules that promote apoptosis. JF - Bioorganic and Medicinal Chemistry Letters AU - Rossi, Matteo AU - Bang, Jeong-kyu AU - Mazur, Sharlyn AU - Iera, Jaclyn A AU - Phillips, Darren C AU - Zambetti, Gerard P AU - Appella, Daniel H AD - Laboratory of Cell Biology, NCI, NIH, Bethesda, MD 20892, United States, appellad@niddk.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 2429 EP - 2434 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 19 IS - 9 SN - 0960-894X, 0960-894X KW - Oncogenes & Growth Factors Abstracts; Biotechnology and Bioengineering Abstracts KW - Cancer KW - Apoptosis KW - Bcl-xL KW - Bcl-x protein KW - BAK protein KW - Bcl-2 protein KW - W 30915:Pharmaceuticals & Vaccines KW - B 26640:Cell Cycle & DNA Repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20563496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Induction+of+apoptosis+promoted+by+Bang52%3B+a+small+molecule+that+downregulates+Bcl-xL&rft.au=Rossi%2C+Matteo%3BBang%2C+Jeong-kyu%3BMazur%2C+Sharlyn%3BIera%2C+Jaclyn+A%3BPhillips%2C+Darren+C%3BZambetti%2C+Gerard+P%3BAppella%2C+Daniel+H&rft.aulast=Rossi&rft.aufirst=Matteo&rft.date=2009-05-01&rft.volume=19&rft.issue=9&rft.spage=2429&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2009.03.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bcl-x protein; Apoptosis; BAK protein; Bcl-2 protein; Cancer DO - http://dx.doi.org/10.1016/j.bmcl.2009.03.067 ER - TY - JOUR T1 - Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones AN - 20562473; 9273170 AB - Using 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one and 4,5-dihydroxy-1H-isoindole-1,3(2H)-dione based HIV-1 integrase inhibitors as display platforms, we undertook a thorough examination of the effects of modifying the halogen substituents on a key benzyl ring that is hypothesized to bind in a hydrophobic pocket of the integrase·DNA complex. Data from this study suggest that in general dihalo-substituted analogues have higher potency than monohalo-substituted compounds, but that further addition of halogens is not beneficial. JF - Bioorganic and Medicinal Chemistry Letters AU - Zhao, Xue Zhi AU - Maddali, Kasthuraiah AU - Vu, B Christie AU - Marchand, Christophe AU - Hughes, Stephen H AU - Pommier, Yves AU - Burke, Terrence R AD - Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, United States, tburke@helix.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 2714 EP - 2717 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 19 IS - 10 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - HIV integrase KW - Inhibitor KW - AIDS KW - Structure-activity relationship KW - Data processing KW - Halogens KW - Human immunodeficiency virus 1 KW - Hydrophobicity KW - Integrase KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20562473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Examination+of+halogen+substituent+effects+on+HIV-1+integrase+inhibitors+derived+from+2%2C3-dihydro-6%2C7-dihydroxy-1H-isoindol-1-ones+and+4%2C5-dihydroxy-1H-isoindole-1%2C3%282H%29-diones&rft.au=Zhao%2C+Xue+Zhi%3BMaddali%2C+Kasthuraiah%3BVu%2C+B+Christie%3BMarchand%2C+Christophe%3BHughes%2C+Stephen+H%3BPommier%2C+Yves%3BBurke%2C+Terrence+R&rft.aulast=Zhao&rft.aufirst=Xue&rft.date=2009-05-01&rft.volume=19&rft.issue=10&rft.spage=2714&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2009.03.122 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Halogens; Hydrophobicity; Integrase; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.bmcl.2009.03.122 ER - TY - JOUR T1 - Supercontinuum white light lasers for flow cytometry AN - 20561983; 9267365 AB - Excitation of fluorescent probes for flow cytometry has traditionally been limited to a few discrete laser lines, an inherent limitation in our ability to excite the vast array of fluorescent probes available for cellular analysis. In this report, we have used a supercontinuum (SC) white light laser as an excitation source for flow cytometry. By selectively filtering the wavelength of interest, almost any laser wavelength in the visible spectrum can be separated and used for flow cytometric analysis. The white light lasers used in this study were integrated into a commercial flow cytometry platform, and a series of high-transmission bandpass filters used to select wavelength ranges from the blue (480 nm) to the long red (>700 nm). Cells labeled with a variety of fluorescent probes or expressing fluorescent proteins were then analyzed, in comparison with traditional lasers emitting at wavelengths similar to the filtered SC source. Based on a standard sensitivity metric, the white light laser bandwidths produced similar excitation levels to traditional lasers for a wide variety of fluorescent probes and expressible proteins. Sensitivity assessment using fluorescent bead arrays confirmed that the SC laser and traditional sources resulted in similar levels of detection sensitivity. Supercontinuum white light laser sources therefore have the potential to remove a significant barrier in flow cytometric analysis, namely the limitation of excitation wavelengths. Almost any visible wavelength range can be made available for excitation, allowing access to virtually any fluorescent probe, and permitting fine-tuning of excitation wavelength to particular probes. JF - Cytometry Part A AU - Telford, William G AU - Subach, Fedor V AU - Verkhusha, Vladislav V AD - Experimental Transplantation and Immunology Branch, NCI-NIH, Bethesda, Maryland, telfordw@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 450 EP - 459 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 75A IS - 5 SN - 1552-4922, 1552-4922 KW - Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Filters KW - Fluorescent indicators KW - Lasers KW - Wavelength KW - Light effects KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20561983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Supercontinuum+white+light+lasers+for+flow+cytometry&rft.au=Telford%2C+William+G%3BSubach%2C+Fedor+V%3BVerkhusha%2C+Vladislav+V&rft.aulast=Telford&rft.aufirst=William&rft.date=2009-05-01&rft.volume=75A&rft.issue=5&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524922&rft_id=info:doi/10.1002%2Fcyto.a.20687 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Filters; Flow cytometry; Fluorescent indicators; Lasers; Wavelength; Light effects DO - http://dx.doi.org/10.1002/cyto.a.20687 ER - TY - JOUR T1 - Characterization of polychlorinated dibenzo-p-dioxin/dibenzofuran emissions from joss paper burned in a furnace with air pollution control devices AN - 20476815; 9164586 AB - Burning joss paper, a common practice in temples in some Asian countries, can release toxic pollutants. This study investigated polychlorinated dibenzo-p-dioxin/dibenzofuran (PCDD/F) emissions and profiles from burning joss paper in a temple furnace connected to two wet scrubbers. The mean total PCDD/F content and corresponding toxic equivalent quantity (TEQ) in joss paper were 193 ng kg super(-) super(1) and 0.645 ng I-TEQ kg super(-) super(1), respectively, whereas those in bottom ash from burned joss paper were 18.5 ng kg super(-) super(1) and 1.92 ng I-TEQ kg super(-) super(1), respectively. The wet scrubbers decreased individual PCDD/F emissions by 26.7-71.0% and those of total PCDD/Fs and I-TEQ by 47.2% and 66.0%, respectively. The total PCDD/F TEQ emission factors before and after the wet scrubbers were 8.14 and 3.42 ?g I-TEQ ton-feedstock super(-) super(1), respectively. The estimated total PCDD/F and corresponding TEQ emissions were 5.29 g year super(-) super(1) and 0.462 g I-TEQ year super(-) super(1), respectively, in Taiwan. Burning joss paper in temple furnaces is a significant source of PCDD/F emissions. JF - Science of the Total Environment AU - Hu, M T AU - Chen, S J AU - Huang, K L AU - Lin, Y C AU - Chang-Chien, G P AU - Tsai, J H AD - National Pingtung University of Science and Technology, 1 Shieh-Fu Rd., Nei Pu 91207, Pingtung, Taiwan, chensj@mail.npust.edu.tw Y1 - 2009/05/01/ PY - 2009 DA - 2009 May 01 SP - 3290 EP - 3294 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 407 IS - 10 SN - 0048-9697, 0048-9697 KW - Toxicology Abstracts; Environment Abstracts; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Taiwan KW - Atmospheric pollution control KW - Ash KW - Air pollution control KW - burning KW - Air pollution KW - Furnaces KW - Pollutants KW - Dibenzofuran KW - Scrubbers KW - Emissions KW - Dibenzo-p-dioxin KW - Pollution control equipment KW - Atmospheric pollution emission KW - Toxic pollutants KW - Burning KW - PCDD KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development KW - X 24360:Metals KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20476815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+of+the+Total+Environment&rft.atitle=Characterization+of+polychlorinated+dibenzo-p-dioxin%2Fdibenzofuran+emissions+from+joss+paper+burned+in+a+furnace+with+air+pollution+control+devices&rft.au=Hu%2C+M+T%3BChen%2C+S+J%3BHuang%2C+K+L%3BLin%2C+Y+C%3BChang-Chien%2C+G+P%3BTsai%2C+J+H&rft.aulast=Hu&rft.aufirst=M&rft.date=2009-05-01&rft.volume=407&rft.issue=10&rft.spage=3290&rft.isbn=&rft.btitle=&rft.title=Science+of+the+Total+Environment&rft.issn=00489697&rft_id=info:doi/10.1016%2Fj.scitotenv.2009.01.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Air pollution; Pollutants; Dibenzofuran; Dibenzo-p-dioxin; Burning; Atmospheric pollution control; Toxic pollutants; Atmospheric pollution emission; Furnaces; Ash; Scrubbers; Emissions; Air pollution control; Pollution control equipment; burning; PCDD; Taiwan DO - http://dx.doi.org/10.1016/j.scitotenv.2009.01.037 ER - TY - JOUR T1 - Anthropometric Measurements, Physical Activity, and the Risk of Symptomatic Gallstone Disease in Chinese Women AN - 20088455; 10183542 AB - Gallstone disease is more common among overweight individuals, particularly in women. We conducted a cross-sectional case-control study of Chinese women nested in the Shanghai Women's Health Study (SWHS) to evaluate the association of gallstone disease with body mass index (BMI), waist to hip ratio (WHR), and physical activity (PA). Methods - The study included 8,485 women with self-reported, physician-diagnosed, prevalent gallstone disease and 16,970 frequency-matched controls by birth year and age at gallstone diagnosis (4-year intervals). Information on height, weight history, waist and hip circumferences, physical activities, and other exposures was obtained by in-person interview. Results - : UsualI (p trend < 0.001) and WHR (p trend < 0.001) were both related to a high prevalence of gallstone disease, and a significant interaction betweenI and WHR on gallstone risk was found (odds ratio [OR] = 3.82, 95%CI [95% confidence interval] 2.47-5.23 for those with both highestI and WHR relative to those with lowestI and WHR, p interaction = 0.03). Gallstone risk was positively associated with cumulative occupational sitting time (p trend = 0.01) and inversely associated with occupational cumulative energy expenditure (p trend = 0.03) as well as with household PA (p trend = 0.02). Conclusions - Our findings further support that overall and central excessive adiposity is an independent risk factor for gallstones in women. In addition, regardless of adiposity level, being physically active may ameliorate the risk of this disease. JF - Annals of Epidemiology AU - Hou, Lifang AU - Shu, Xiao-Ou AU - Gao, Yu-Tang AU - Ji, Bu-Tian AU - Weiss, Jocelyn M AU - Yang, Gong AU - Li, Hong-Lan AU - Blair, Aaron AU - Zheng, Wei AU - Chow, Wong-Ho AD - Department of Preventive Medicine, Northwestern University, Chicago Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Center for Health Service Research, Vanderbilt University, Nashville, TN Shanghai Cancer Institute, Shanghai, China, l-hou@northwestern.edu Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 344 EP - 350 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 19 IS - 5 SN - 1047-2797, 1047-2797 KW - Physical Education Index; Risk Abstracts KW - Body Mass Index KW - Gallstone Disease Risk KW - Physical Activity KW - Waist-to-Hip Ratio KW - Historical account KW - Age KW - Body mass KW - Women KW - obesity KW - Exercise KW - Hips KW - households KW - Waist KW - Epidemiology KW - body mass KW - China, People's Rep., Shanghai KW - Females KW - Diseases KW - Interviews KW - physical activity KW - Trends KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20088455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Anthropometric+Measurements%2C+Physical+Activity%2C+and+the+Risk+of+Symptomatic+Gallstone+Disease+in+Chinese+Women&rft.au=Hou%2C+Lifang%3BShu%2C+Xiao-Ou%3BGao%2C+Yu-Tang%3BJi%2C+Bu-Tian%3BWeiss%2C+Jocelyn+M%3BYang%2C+Gong%3BLi%2C+Hong-Lan%3BBlair%2C+Aaron%3BZheng%2C+Wei%3BChow%2C+Wong-Ho&rft.aulast=Hou&rft.aufirst=Lifang&rft.date=2009-05-01&rft.volume=19&rft.issue=5&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2008.12.002 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Epidemiology; Waist; Body mass; Women; Interviews; Exercise; Diseases; Trends; Hips; Historical account; Age; households; body mass; obesity; Females; physical activity; China, People's Rep., Shanghai DO - http://dx.doi.org/10.1016/j.annepidem.2008.12.002 ER - TY - JOUR T1 - SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma AN - 20080376; 10068107 AB - CD133+ populations of human glioblastoma multiforme (GBM) cells are reportedly enriched for tumor stem cells (TSCs) or tumor-initiating cells (TICs). Approximately 40% of freshly isolated GBM specimens, however, do not contain CD133+ tumor cells, raising the possibility that CD133 may not be a universal enrichment marker for GBM TSCs/TICs. Here we demonstrate that stage-specific embryonic antigen 1(SSEA-1/LeX)+ GBM cells fulfill the functional criteria for TSC/TIC, since (1) SSEA-1+ cells are highly tumorigenic in vivo, unlike SSEA-1- cells; (2) SSEA-1+ cells can give rise to both SSEA-1+ and SSEA-1- cells, thereby establishing a cellular hierarchy; and (3) SSEA-1+ cells have self-renewal and multilineage differentiation potentials. A distinct subpopulation of SSEA-1+ cells was present in all but one of the primary GBMs examined (n = 24), and most CD133+ tumor cells were also SSEA-1+, suggesting that SSEA-1 may be a general TSC/TIC enrichment marker in human GBMs. JF - Cell Stem Cell AU - Son, Myung Jin AU - Woolard, Kevin AU - Nam, Do-Hyun AU - Lee, Jeongwu AU - Fine, Howard A AD - Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, leejeo@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 440 EP - 452 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 4 IS - 5 SN - 1934-5909, 1934-5909 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - STEMCELL KW - Differentiation KW - Glioblastoma KW - Stem cells KW - glioblastoma multiforme KW - Embryos KW - Tumors KW - Tumor cells KW - W 30965:Miscellaneous, Reviews KW - N3 11150:General and miscellaneous topics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20080376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Stem+Cell&rft.atitle=SSEA-1+Is+an+Enrichment+Marker+for+Tumor-Initiating+Cells+in+Human+Glioblastoma&rft.au=Son%2C+Myung+Jin%3BWoolard%2C+Kevin%3BNam%2C+Do-Hyun%3BLee%2C+Jeongwu%3BFine%2C+Howard+A&rft.aulast=Son&rft.aufirst=Myung&rft.date=2009-05-01&rft.volume=21&rft.issue=5&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Neurology&rft.issn=13515101&rft_id=info:doi/10.1111%2Fene.12274 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Glioblastoma; Differentiation; Stem cells; glioblastoma multiforme; Embryos; Tumors; Tumor cells DO - http://dx.doi.org/10.1016/j.stem.2009.03.003 ER - TY - CPAPER T1 - Pharmacological Inhibition of Xanthine Oxidase Attenuates the Development of Diabetic Cardiomyopathy T2 - 2009 Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference (ATVB 2009) AN - 41795855; 5046954 JF - 2009 Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference (ATVB 2009) AU - Mohanraj, Rajesh AU - Mukhopadhyay, Partha AU - Batkai, Sandor AU - Mukhopadhyay, Bani AU - Patel, Vivek AU - Pacher, Pal Y1 - 2009/04/29/ PY - 2009 DA - 2009 Apr 29 KW - Diabetes mellitus KW - Cardiomyopathy KW - Xanthine oxidase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41795855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology+Annual+Conference+%28ATVB+2009%29&rft.atitle=Pharmacological+Inhibition+of+Xanthine+Oxidase+Attenuates+the+Development+of+Diabetic+Cardiomyopathy&rft.au=Mohanraj%2C+Rajesh%3BMukhopadhyay%2C+Partha%3BBatkai%2C+Sandor%3BMukhopadhyay%2C+Bani%3BPatel%2C+Vivek%3BPacher%2C+Pal&rft.aulast=Mohanraj&rft.aufirst=Rajesh&rft.date=2009-04-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology+Annual+Conference+%28ATVB+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1239305234814ATVB%20Fi nalProg%20WEB_0309.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Native Low-Density Lipoprotein Uptake by Macrophage Colony-Stimulating Factor Differentiated Macrophages Is Mediated by Macropinocytosis and Micropinocytosis T2 - 2009 Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference (ATVB 2009) AN - 41785452; 5046510 JF - 2009 Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference (ATVB 2009) AU - Anzinger, Joshua AU - Chang, Janet AU - Leyva, Francisco AU - Kruth, Howard Y1 - 2009/04/29/ PY - 2009 DA - 2009 Apr 29 KW - Lipoproteins KW - Macrophage colony-stimulating factor KW - Macrophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41785452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Arteriosclerosis%2C+Thrombosis+and+Vascular+Biology+Annual+Conference+%28ATVB+2009%29&rft.atitle=Native+Low-Density+Lipoprotein+Uptake+by+Macrophage+Colony-Stimulating+Factor+Differentiated+Macrophages+Is+Mediated+by+Macropinocytosis+and+Micropinocytosis&rft.au=Anzinger%2C+Joshua%3BChang%2C+Janet%3BLeyva%2C+Francisco%3BKruth%2C+Howard&rft.aulast=Anzinger&rft.aufirst=Joshua&rft.date=2009-04-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Children%27s+Health+Care&rft.issn=02739615&rft_id=info:doi/10.1080%2F02739615.2014.986328 L2 - http://www.americanheart.org/downloadable/heart/1239305234814ATVB%20Fi nalProg%20WEB_0309.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epigenetic Genome Control by RNAi and Transposon-Derived Proteins T2 - 2009 Keystone Symposia on the Biology of RNA Silencing (D6) AN - 41941494; 5114927 JF - 2009 Keystone Symposia on the Biology of RNA Silencing (D6) AU - Grewal, Shiv Y1 - 2009/04/25/ PY - 2009 DA - 2009 Apr 25 KW - Genomes KW - RNA-mediated interference KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41941494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+the+Biology+of+RNA+Silencing+%28D6%29&rft.atitle=Epigenetic+Genome+Control+by+RNAi+and+Transposon-Derived+Proteins&rft.au=Grewal%2C+Shiv&rft.aulast=Grewal&rft.aufirst=Shiv&rft.date=2009-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+the+Biology+of+RNA+Silencing+%28D6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 02 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of an RNA-Dependent RNA Polymerase in Drosophila Involved in RNAi and Transposon Suppression T2 - 2009 Keystone Symposia on the Biology of RNA Silencing (D6) AN - 41904843; 5114923 JF - 2009 Keystone Symposia on the Biology of RNA Silencing (D6) AU - Paterson, Bruce Y1 - 2009/04/25/ PY - 2009 DA - 2009 Apr 25 KW - RNA-directed RNA polymerase KW - RNA-mediated interference KW - DNA-directed RNA polymerase KW - Transposons KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41904843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+the+Biology+of+RNA+Silencing+%28D6%29&rft.atitle=Identification+of+an+RNA-Dependent+RNA+Polymerase+in+Drosophila+Involved+in+RNAi+and+Transposon+Suppression&rft.au=Paterson%2C+Bruce&rft.aulast=Paterson&rft.aufirst=Bruce&rft.date=2009-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+the+Biology+of+RNA+Silencing+%28D6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 02 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Identification of a Post-targeting Step Required for Efficient Cotranslational Translocation of Proteins across the Escherichia coli Inner Membrane AN - 21079422; 11080762 AB - Recent studies have shown that cytoplasmic proteins are exported efficiently in Escherichia coli only if they are attached to signal peptides that are recognized by the signal recognition particle and are thereby targeted to the SecYEG complex cotranslationally. The evidence suggests that the entry of these proteins into the secretory pathway at an early stage of translation is necessary to prevent them from folding into a translocation-incompetent conformation. We found, however, that several glycolytic enzymes attached to signal peptides that are recognized by the signal recognition particle were exported inefficiently. Based on previous studies of post-translational export, we hypothesized that the export block was due to the presence of basic residues at the extreme N terminus of each enzyme. Consistent with our hypothesis, we found that the introduction of negatively charged residues into this segment increased the efficiency of export. Export efficiency was sensitive to the number, position, and sequence context of charged residues. The importance of charge for efficient export was underscored by an in silico analysis that revealed a conserved negative charge bias at the N terminus of the mature region of bacterial presecretory proteins. Our results demonstrate that cotranslational targeting of a protein to the E. coli SecYEG complex does not ensure its export but that export also depends on a subsequent event (most likely the initiation of translocation) that involves sequences both within and just beyond the signal peptide. JF - Journal of Biological Chemistry AU - Tian, Pu AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0538 Y1 - 2009/04/24/ PY - 2009 DA - 2009 Apr 24 SP - 11396 EP - 11404 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 284 IS - 17 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Translation KW - Protein transport KW - Post-translation KW - Signal recognition particle KW - Inner membranes KW - Signal peptides KW - Escherichia coli KW - Enzymes KW - Glycolysis KW - Translocation KW - J 02330:Biochemistry KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21079422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Identification+of+a+Post-targeting+Step+Required+for+Efficient+Cotranslational+Translocation+of+Proteins+across+the+Escherichia+coli+Inner+Membrane&rft.au=Tian%2C+Pu%3BBernstein%2C+Harris+D&rft.aulast=Tian&rft.aufirst=Pu&rft.date=2009-04-24&rft.volume=284&rft.issue=17&rft.spage=11396&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M900375200 L2 - http://www.jbc.org/cgi/reprint/284/17/11396.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Protein transport; Translation; Post-translation; Inner membranes; Signal recognition particle; Signal peptides; Enzymes; Translocation; Glycolysis; Escherichia coli DO - http://dx.doi.org/10.1074/jbc.M900375200 ER - TY - JOUR T1 - N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists. AN - 67132245; 19331412 AB - In the present report, the D3 receptor pharmacophore is modified in the 2,3-diCl- and 2-OCH(3)-phenylpiperazine class of compounds with the goal to improve D3 receptor affinity and selectivity. This extension of structure-activity relationships (SAR) has resulted in the identification of the first enantioselective D3 antagonists (R- and S-22) to be reported, wherein enantioselectivity is more pronounced at D3 than at D2, and that a binding region on the second extracellular loop (E2) may play a role in both enantioselectivity and D3 receptor selectivity. Moreover, we have discovered some of the most D3-selective compounds reported to date that show high affinity (K(i) = 1 nM) for D3 and approximately 400-fold selectivity over the D2 receptor subtype. Several of these analogues showed exquisite selectivity for D3 receptors over >60 other receptors, further underscoring their value as in vivo research tools. These lead compounds also have appropriate physical characteristics for in vivo exploration and therefore will be useful in determining how intrinsic activity at D3 receptors tested in vitro is related to behaviors in animal models of addiction and other neuropsychiatric disorders. JF - Journal of medicinal chemistry AU - Newman, Amy Hauck AU - Grundt, Peter AU - Cyriac, George AU - Deschamps, Jeffrey R AU - Taylor, Michelle AU - Kumar, Rakesh AU - Ho, David AU - Luedtke, Robert R AD - Medicinal Chemistry Section, National Institute on Drug AbuseIntramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, USA. anewman@intra.nida.nih.gov Y1 - 2009/04/23/ PY - 2009 DA - 2009 Apr 23 SP - 2559 EP - 2570 VL - 52 IS - 8 KW - Dopamine D2 Receptor Antagonists KW - 0 KW - Indoles KW - Ligands KW - N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)-1H-indole-2-carboxamide KW - Piperazines KW - Receptors, Dopamine D2 KW - Receptors, Dopamine D3 KW - Recombinant Fusion Proteins KW - Receptors, Dopamine D4 KW - 137750-34-6 KW - Index Medicus KW - Recombinant Fusion Proteins -- antagonists & inhibitors KW - Stereoisomerism KW - Drug Partial Agonism KW - Humans KW - Radioligand Assay KW - Structure-Activity Relationship KW - Binding Sites KW - Receptors, Dopamine D4 -- antagonists & inhibitors KW - Binding, Competitive KW - Recombinant Fusion Proteins -- genetics KW - Crystallography, X-Ray KW - Receptors, Dopamine D2 -- genetics KW - Allosteric Site KW - Cell Line KW - Receptors, Dopamine D3 -- agonists KW - Piperazines -- chemical synthesis KW - Piperazines -- chemistry KW - Receptors, Dopamine D3 -- genetics KW - Receptors, Dopamine D3 -- antagonists & inhibitors KW - Indoles -- chemical synthesis KW - Indoles -- pharmacology KW - Piperazines -- pharmacology KW - Indoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67132245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=N-%284-%284-%282%2C3-dichloro-+or+2-methoxyphenyl%29piperazin-1-yl%29butyl%29heterobiarylcarboxamides+with+functionalized+linking+chains+as+high+affinity+and+enantioselective+D3+receptor+antagonists.&rft.au=Newman%2C+Amy+Hauck%3BGrundt%2C+Peter%3BCyriac%2C+George%3BDeschamps%2C+Jeffrey+R%3BTaylor%2C+Michelle%3BKumar%2C+Rakesh%3BHo%2C+David%3BLuedtke%2C+Robert+R&rft.aulast=Newman&rft.aufirst=Amy&rft.date=2009-04-23&rft.volume=52&rft.issue=8&rft.spage=2559&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm900095y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-06 N1 - Date created - 2009-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1999 Jul 22;400(6742):371-5 [10432116] Bioorg Med Chem Lett. 2003 Jul 7;13(13):2179-83 [12798330] J Med Chem. 2005 Feb 10;48(3):839-48 [15689168] Synapse. 2005 Jul;57(1):17-28 [15858839] J Med Chem. 2005 Jun 2;48(11):3663-79 [15916415] Brain Res Brain Res Rev. 2005 Jul;49(1):77-105 [15960988] J Pharmacol Exp Ther. 2005 Jul;314(1):310-9 [15833897] Drug Discov Today. 2005 Jul 1;10(13):917-25 [15993811] Bioorg Med Chem Lett. 2005 Nov 1;15(21):4819-23 [16139501] Mol Pharmacol. 2006 Jan;69(1):185-94 [16236817] J Med Chem. 2006 Jan 12;49(1):358-65 [16392820] Neuropsychopharmacology. 2006 Jul;31(7):1393-405 [16205781] Nucl Med Biol. 2006 Aug;33(6):785-95 [16934697] Pharmacol Ther. 2006 Oct;112(1):281-333 [16905195] J Pharmacol Exp Ther. 2007 Jan;320(1):1-13 [16803859] Int J Neuropsychopharmacol. 2007 Apr;10(2):167-81 [16426478] J Pharmacol Exp Ther. 2007 Mar;320(3):1268-78 [17170312] J Pharmacol Exp Ther. 2007 May;321(2):573-82 [17272677] Psychopharmacology (Berl). 2007 Aug;193(2):159-70 [17393143] CNS Drug Rev. 2007 Summer;13(2):240-59 [17627675] J Neurochem. 2007 Aug;102(4):1410-24 [17532788] J Med Chem. 2007 Aug 23;50(17):4135-46 [17672446] J Med Chem. 2007 Oct 18;50(21):5076-89 [17867665] Science. 2007 Nov 23;318(5854):1258-65 [17962520] J Med Chem. 2008 Jan 10;51(1):101-17 [18072730] J Pharmacol Exp Ther. 2008 Feb;324(2):600-11 [18024787] J Pharmacol Exp Ther. 2008 Feb;324(2):587-99 [18024789] Psychopharmacology (Berl). 2008 Mar;196(4):533-42 [17985117] J Med Chem. 2003 Aug 28;46(18):3883-99 [12930150] J Med Chem. 2003 Nov 6;46(23):4952-64 [14584946] Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):440-5 [14704269] Bioorg Med Chem Lett. 2004 Aug 2;14(15):3963-6 [15225707] Neurochem Int. 2004 Oct;45(5):609-17 [15234102] Nature. 1990 Sep 13;347(6289):146-51 [1975644] Bioorg Med Chem Lett. 1998 Oct 6;8(19):2715-8 [9873609] Bioorg Med Chem. 2005 Jan 3;13(1):77-87 [15582454] J Pharmacol Exp Ther. 2008 Mar;324(3):1212-26 [18096759] J Med Chem. 2008 May 22;51(10):3005-19 [18410082] Parkinsonism Relat Disord. 2008;14 Suppl 2:S139-44 [18585083] Nature. 2008 Jul 24;454(7203):486-91 [18594507] J Med Chem. 2008 Aug 14;51(15):4529-38 [18598015] J Med Chem. 2008 Oct 9;51(19):6095-109 [18774793] J Med Chem. 2008 Oct 9;51(19):5905-8 [18785726] J Biol Chem. 2008 Oct 24;283(43):29312-21 [18723515] Mol Pharmacol. 1999 Nov;56(5):1025-30 [10531409] J Med Chem. 2000 May 4;43(9):1878-85 [10794704] Naunyn Schmiedebergs Arch Pharmacol. 2000 May;361(5):569-72 [10832613] Science. 2000 Aug 4;289(5480):739-45 [10926528] J Pharmacol Exp Ther. 2000 Sep;294(3):1154-65 [10945872] J Med Chem. 2000 Oct 5;43(20):3714-7 [11020286] Synapse. 2000 Dec 15;38(4):438-49 [11044891] Eur J Pharmacol. 2000 Oct 27;407(1-2):47-51 [11050289] Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26 [11259830] Behav Pharmacol. 2001 Feb;12(1):1-11 [11270507] J Pharmacol Toxicol Methods. 2000 Jul-Aug;44(1):235-49 [11274893] Eur J Pharmacol. 2001 Jul 20;424(2):85-90 [11476753] J Med Chem. 2001 Sep 13;44(19):3175-86 [11543687] J Neurosci. 2002 Nov 1;22(21):9595-603 [12417684] Mol Pharmacol. 1999 Mar;55(3):564-74 [10051542] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm900095y ER - TY - CPAPER T1 - Reframing the "Cholesterol Controversy": Etiology, Epidemiology, and Memory in Postwar American Medicine T2 - 82nd Annual Meeting of the American Association for the History of Medicine (AAHM 2009) AN - 41920223; 5097259 JF - 82nd Annual Meeting of the American Association for the History of Medicine (AAHM 2009) AU - Olszewski, Todd Y1 - 2009/04/23/ PY - 2009 DA - 2009 Apr 23 KW - Cholesterol KW - Etiology KW - Memory KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41920223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=82nd+Annual+Meeting+of+the+American+Association+for+the+History+of+Medicine+%28AAHM+2009%29&rft.atitle=Reframing+the+%22Cholesterol+Controversy%22%3A+Etiology%2C+Epidemiology%2C+and+Memory+in+Postwar+American+Medicine&rft.au=Olszewski%2C+Todd&rft.aulast=Olszewski&rft.aufirst=Todd&rft.date=2009-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=82nd+Annual+Meeting+of+the+American+Association+for+the+History+of+Medicine+%28AAHM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.histmed.org/documents/aahm_pro_2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Recent History of Complementary and Alternative Medicine at the National Institutes of Health, 1991-2008 T2 - 82nd Annual Meeting of the American Association for the History of Medicine (AAHM 2009) AN - 41901111; 5097299 JF - 82nd Annual Meeting of the American Association for the History of Medicine (AAHM 2009) AU - Boyle, Eric Y1 - 2009/04/23/ PY - 2009 DA - 2009 Apr 23 KW - Historical account KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41901111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=82nd+Annual+Meeting+of+the+American+Association+for+the+History+of+Medicine+%28AAHM+2009%29&rft.atitle=The+Recent+History+of+Complementary+and+Alternative+Medicine+at+the+National+Institutes+of+Health%2C+1991-2008&rft.au=Boyle%2C+Eric&rft.aulast=Boyle&rft.aufirst=Eric&rft.date=2009-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=82nd+Annual+Meeting+of+the+American+Association+for+the+History+of+Medicine+%28AAHM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.histmed.org/documents/aahm_pro_2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patenting in Biomedicine: The Ownership and Dissemination of Biomedical Innovations and the NIH's Shift in Patent Policy in the 1960s and 1970s T2 - 82nd Annual Meeting of the American Association for the History of Medicine (AAHM 2009) AN - 41895580; 5097300 JF - 82nd Annual Meeting of the American Association for the History of Medicine (AAHM 2009) AU - Yi, Doogab Y1 - 2009/04/23/ PY - 2009 DA - 2009 Apr 23 KW - Patents KW - Innovations KW - Policies KW - Property rights KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41895580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=82nd+Annual+Meeting+of+the+American+Association+for+the+History+of+Medicine+%28AAHM+2009%29&rft.atitle=Patenting+in+Biomedicine%3A+The+Ownership+and+Dissemination+of+Biomedical+Innovations+and+the+NIH%27s+Shift+in+Patent+Policy+in+the+1960s+and+1970s&rft.au=Yi%2C+Doogab&rft.aulast=Yi&rft.aufirst=Doogab&rft.date=2009-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=82nd+Annual+Meeting+of+the+American+Association+for+the+History+of+Medicine+%28AAHM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.histmed.org/documents/aahm_pro_2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Demethylation and Antitumor Potential of Zebularine in Liver Cancer T2 - 44th Annual Meeting of the European Association for the Study of the Liver AN - 42087232; 5135651 JF - 44th Annual Meeting of the European Association for the Study of the Liver AU - Andersen, J AU - Raggi, C AU - Marquardt, J AU - Conner, E AU - Lee, Y AU - Factor, V AU - Thorgeirsson, S Y1 - 2009/04/22/ PY - 2009 DA - 2009 Apr 22 KW - Liver cancer KW - Demethylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42087232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.atitle=Modulation+of+Demethylation+and+Antitumor+Potential+of+Zebularine+in+Liver+Cancer&rft.au=Andersen%2C+J%3BRaggi%2C+C%3BMarquardt%2C+J%3BConner%2C+E%3BLee%2C+Y%3BFactor%2C+V%3BThorgeirsson%2C+S&rft.aulast=Andersen&rft.aufirst=J&rft.date=2009-04-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/easl2009/Orals/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sphingosine-1-Phosphate, a Determinant of Mast Cell Responsiveness T2 - 2009 Meeting of the Complex Lipids in Biology: Signaling, Compartmentalization and Disease (Z4) AN - 41895009; 5113100 JF - 2009 Meeting of the Complex Lipids in Biology: Signaling, Compartmentalization and Disease (Z4) AU - Olivera, Ana Y1 - 2009/04/22/ PY - 2009 DA - 2009 Apr 22 KW - Mast cells KW - Sphingosine 1-phosphate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41895009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Meeting+of+the+Complex+Lipids+in+Biology%3A+Signaling%2C+Compartmentalization+and+Disease+%28Z4%29&rft.atitle=Sphingosine-1-Phosphate%2C+a+Determinant+of+Mast+Cell+Responsiveness&rft.au=Olivera%2C+Ana&rft.aulast=Olivera&rft.aufirst=Ana&rft.date=2009-04-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Meeting+of+the+Complex+Lipids+in+Biology%3A+Signaling%2C+Compartmentalization+and+Disease+%28Z4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=96 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sphingosine-1-Phosphate and its Role in Physiology T2 - 2009 Meeting of the Complex Lipids in Biology: Signaling, Compartmentalization and Disease (Z4) AN - 41894974; 5113089 JF - 2009 Meeting of the Complex Lipids in Biology: Signaling, Compartmentalization and Disease (Z4) AU - Proia, Richard Y1 - 2009/04/22/ PY - 2009 DA - 2009 Apr 22 KW - Physiology KW - Sphingosine 1-phosphate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41894974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Meeting+of+the+Complex+Lipids+in+Biology%3A+Signaling%2C+Compartmentalization+and+Disease+%28Z4%29&rft.atitle=Sphingosine-1-Phosphate+and+its+Role+in+Physiology&rft.au=Proia%2C+Richard&rft.aulast=Proia&rft.aufirst=Richard&rft.date=2009-04-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Meeting+of+the+Complex+Lipids+in+Biology%3A+Signaling%2C+Compartmentalization+and+Disease+%28Z4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=96 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Scent marking and countermarking behaviors as a measure of olfactory communication in the BTBR T+tf/J inbred strain, a mouse model of autism T2 - 31st Annual Meeting of the Association for Chemoreception Sciences (AChemS 2009) AN - 41801287; 5048623 JF - 31st Annual Meeting of the Association for Chemoreception Sciences (AChemS 2009) AU - Roullet, Florence AU - Wohr, Markus AU - Yang, Mu AU - Crawley, Jacqueline Y1 - 2009/04/22/ PY - 2009 DA - 2009 Apr 22 KW - Communication KW - Autism KW - Chemical communication KW - Animal models KW - Marking behavior KW - Scent marking behavior KW - Inbreeding KW - Olfaction KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41801287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Psychology&rft.atitle=%27I%27m+cured+but%E2%80%A6.%27%3A+Perceptions+of+illness+following+treatment&rft.au=O%E2%80%99Connor%2C+K.+P.%3BJanelle%2C+C.%3BCoutu%2C+M.-F.%3BRouleau%2C+A.%3BLessard%2C+M.-+J.%3BKirouac%2C+C.%3BMarchand%2C+A.%3BDupuis%2C+G.%3BTurgeon%2C+L.%3BB%C3%A9langer%2C+M.-P.&rft.aulast=O%E2%80%99Connor&rft.aufirst=K.&rft.date=2009-03-01&rft.volume=14&rft.issue=2&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105308100212 L2 - http://www.achems.org/files/public/PROGRAMFINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa AN - 20232280; 10319562 AB - Reports from the United States have demonstrated that elevated markers of microbial translocation from the gut may be found in chronic and advanced HIV-1 infection and are associated with an increase in immune activation. However, this phenomenon's role in HIV-1 disease in Africa is unknown. This study examined the longitudinal relationship between microbial translocation and circulating inflammatory cytokine responses in a cohort of people with varying rates of HIV-1 disease progression in Rakai, Uganda. Multiple markers for microbial translocation (lipopolysaccharide, endotoxin antibody, and sCD14) did not change significantly during HIV-1 disease progression. Moreover, circulating immunoreactive cytokine levels either decreased or remained virtually unchanged throughout disease progression. These data suggest that microbial translocation and its subsequent inflammatory immune response do not have a causal relationship with HIV-1 disease progression in Africa. JF - Proceedings of the National Academy of Sciences, USA AU - Redd, Andrew D AU - Dabitao, Djeneba AU - Bream, Jay H AU - Charvat, Blake AU - Laeyendecker, Oliver AU - Kiwanuka, Noah AU - Lutalo, Tom AU - Kigozi, Godfrey AU - Tobian, Aaron AR AU - Gamiel, Jordyn AU - Neal, Jessica D AU - Oliver, Amy E AU - Margolick, Joseph B AU - Sewankambo, Nelson AU - Reynolds, Steven J AU - Wawer, Maria J AU - Serwadda, David AU - Gray, Ronald H AU - Quinn, Thomas C AD - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, tquinn@jhmi.edu Y1 - 2009/04/21/ PY - 2009 DA - 2009 Apr 21 SP - 6718 EP - 6723 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 16 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Endotoxins KW - Antibodies KW - Digestive tract KW - Data processing KW - Human immunodeficiency virus 1 KW - Chronic infection KW - Cytokines KW - Lipopolysaccharides KW - Immune response KW - Translocation KW - Inflammation KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20232280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Microbial+translocation%2C+the+innate+cytokine+response%2C+and+HIV-1+disease+progression+in+Africa&rft.au=Redd%2C+Andrew+D%3BDabitao%2C+Djeneba%3BBream%2C+Jay+H%3BCharvat%2C+Blake%3BLaeyendecker%2C+Oliver%3BKiwanuka%2C+Noah%3BLutalo%2C+Tom%3BKigozi%2C+Godfrey%3BTobian%2C+Aaron+AR%3BGamiel%2C+Jordyn%3BNeal%2C+Jessica+D%3BOliver%2C+Amy+E%3BMargolick%2C+Joseph+B%3BSewankambo%2C+Nelson%3BReynolds%2C+Steven+J%3BWawer%2C+Maria+J%3BSerwadda%2C+David%3BGray%2C+Ronald+H%3BQuinn%2C+Thomas+C&rft.aulast=Redd&rft.aufirst=Andrew&rft.date=2009-04-21&rft.volume=106&rft.issue=16&rft.spage=6718&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0901983106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Endotoxins; Antibodies; Data processing; Digestive tract; Chronic infection; Lipopolysaccharides; Cytokines; Immune response; Translocation; Inflammation; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1073/pnas.0901983106 ER - TY - CPAPER T1 - The Evolution of Viral Vaccinology T2 - 25th Annual Clinical Virology Symposium AN - 41753318; 5045968 JF - 25th Annual Clinical Virology Symposium AU - Graham, Barney Y1 - 2009/04/19/ PY - 2009 DA - 2009 Apr 19 KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41753318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Clinical+Virology+Symposium&rft.atitle=The+Evolution+of+Viral+Vaccinology&rft.au=Graham%2C+Barney&rft.aulast=Graham&rft.aufirst=Barney&rft.date=2009-04-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Clinical+Virology+Symposium&rft.issn=&rft_id=info:doi/ L2 - http://hsc.usf.edu/nocms/medicine/medmicro/virology/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nuclear receptor dependent chromatin remodeling T2 - 2009 Conference on Experimental Biology AN - 40403281; 5291390 JF - 2009 Conference on Experimental Biology AU - Archer, T Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Chromatin remodeling KW - Nuclear receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40403281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=Nuclear+receptor+dependent+chromatin+remodeling&rft.au=Archer%2C+T&rft.aulast=Archer&rft.aufirst=T&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alterations in D2 dopamine receptor internalization in the presence of the Na+/K+-ATPase T2 - 2009 Conference on Experimental Biology AN - 40396860; 5292666 JF - 2009 Conference on Experimental Biology AU - Hazelwood, L AU - Free, R AU - Cabrera, D AU - Sibley, D Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Dopamine D2 receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40396860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=Alterations+in+D2+dopamine+receptor+internalization+in+the+presence+of+the+Na%2B%2FK%2B-ATPase&rft.au=Hazelwood%2C+L%3BFree%2C+R%3BCabrera%2C+D%3BSibley%2C+D&rft.aulast=Hazelwood&rft.aufirst=L&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High NaCl activates c-Abl kinase, phosphorylating TonEBP/OREBP on Y143, which contributes to its increased nuclear localization T2 - 2009 Conference on Experimental Biology AN - 40394966; 5293317 JF - 2009 Conference on Experimental Biology AU - Gallazzini, M AU - Villers, C AU - Burg, M AU - Ferraris, J Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Sodium chloride KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40394966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=High+NaCl+activates+c-Abl+kinase%2C+phosphorylating+TonEBP%2FOREBP+on+Y143%2C+which+contributes+to+its+increased+nuclear+localization&rft.au=Gallazzini%2C+M%3BVillers%2C+C%3BBurg%2C+M%3BFerraris%2C+J&rft.aulast=Gallazzini&rft.aufirst=M&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - S-nitrosylation signaling in the setting of ischemia T2 - 2009 Conference on Experimental Biology AN - 40394281; 5293565 JF - 2009 Conference on Experimental Biology AU - Murphy, E Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Ischemia KW - Signal transduction KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40394281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=S-nitrosylation+signaling+in+the+setting+of+ischemia&rft.au=Comings%2C+David+E.%3BComings%2C+Brenda+G.&rft.aulast=Comings&rft.aufirst=David&rft.date=1987-08-01&rft.volume=151&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.151.2.195 L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Marine-sourced secondary metabolites as leads to drugs T2 - 2009 Conference on Experimental Biology AN - 40393706; 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5288054 JF - 2009 Conference on Experimental Biology AU - Franco, R AU - Cidlowski, J Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Apoptosis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40376742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=Protein+glutathionylation+regulates+FasL-induced+apoptosis&rft.au=Franco%2C+R%3BCidlowski%2C+J&rft.aulast=Franco&rft.aufirst=R&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of His-tag and immunoprecipitation procedures for recombinant protein purification T2 - 2009 Conference on Experimental Biology AN - 40376120; 5287975 JF - 2009 Conference on Experimental Biology AU - Lin, R AU - Cao, H Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Immunoprecipitation KW - Protein purification KW - Recombinants KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40376120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=Evaluation+of+His-tag+and+immunoprecipitation+procedures+for+recombinant+protein+purification&rft.au=Lin%2C+R%3BCao%2C+H&rft.aulast=Lin&rft.aufirst=R&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation and characterization of mouse UDP-glucuronosyltransferase homologs of human isozymes that inactivate mutagenizing catechol estrogens T2 - 2009 Conference on Experimental Biology AN - 40373242; 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5289518 JF - 2009 Conference on Experimental Biology AU - Kleeberger, S Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Lung diseases KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40372892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+Anxiety&rft.atitle=Obsessive-compulsive+spectrum+conditions+in+obsessive-compulsive+disorder+and+other+anxiety+disorders&rft.au=Richter%2C+Margaret+A.%3BSummerfeldt%2C+Laura+J.%3BAntony%2C+Martin+M.%3BSwinson%2C+Richard+P.&rft.aulast=Richter&rft.aufirst=Margaret&rft.date=2003-01-01&rft.volume=18&rft.issue=3&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Depression+and+Anxiety&rft.issn=10914269&rft_id=info:doi/10.1002%2Fda.10126 L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Live cell single particle tracking/photoactivated localization microscopy T2 - 2009 Conference on Experimental Biology AN - 40370753; 5287588 JF - 2009 Conference on Experimental Biology AU - Lippincott-Schwartz, J Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Particulates KW - Microscopy KW - Tracking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40370753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=Live+cell+single+particle+tracking%2Fphotoactivated+localization+microscopy&rft.au=Lippincott-Schwartz%2C+J&rft.aulast=Lippincott-Schwartz&rft.aufirst=J&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calculating the permanent lifestyle changes required for weight-loss maintenance T2 - 2009 Conference on Experimental Biology AN - 40370414; 5289313 JF - 2009 Conference on Experimental Biology AU - Hall, K AU - Jordan, P Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Maintenance KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40370414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=Calculating+the+permanent+lifestyle+changes+required+for+weight-loss+maintenance&rft.au=Hall%2C+K%3BJordan%2C+P&rft.aulast=Hall&rft.aufirst=K&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Principles of biomarker characterization for epidemiological studies T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40363741; 5270625 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Rothman, Nathaniel Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Bioindicators KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40363741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Principles+of+biomarker+characterization+for+epidemiological+studies&rft.au=Rothman%2C+Nathaniel&rft.aulast=Rothman&rft.aufirst=Nathaniel&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090418.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hsp90:What is the pathway? T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40363651; 5270597 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Neckers, Leonard Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40363651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychopharmacology&rft.atitle=Editorial%3A+Anxiety+and+OCD+--+The+chicken+or+the+egg%3F&rft.au=Nutt%2C+David%3BMalizia%2C+Andrea&rft.aulast=Nutt&rft.aufirst=David&rft.date=2006-11-01&rft.volume=20&rft.issue=6&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychopharmacology&rft.issn=02698811&rft_id=info:doi/10.1177%2F0269881106068424 L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090418.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Grantsmanship, Junior Faculty T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40362208; 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5270618 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Kobayashi, Hisataka Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Tumors KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=New+activation+mechanisms+for+optical+molecular+imaging+of+tumors&rft.au=Kobayashi%2C+Hisataka&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090418.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integrated genomics and transcriptional mapping T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40356684; 5270665 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Meltzer, Paul Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Gene mapping KW - Transcription KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Integrated+genomics+and+transcriptional+mapping&rft.au=Meltzer%2C+Paul&rft.aulast=Meltzer&rft.aufirst=Paul&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090418.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Asking and answering questions: The role of molecular imaging in the oncology clinic T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40356647; 5270740 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Choyke, Peter Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Oncology KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Asking+and+answering+questions%3A+The+role+of+molecular+imaging+in+the+oncology+clinic&rft.au=Choyke%2C+Peter&rft.aulast=Choyke&rft.aufirst=Peter&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090418.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Systems analysis of inherited breast cancer metastasis susceptibility T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40356520; 5270623 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Hunter, Kent Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Genetics KW - Systems analysis KW - Metastases KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Systems+analysis+of+inherited+breast+cancer+metastasis+susceptibility&rft.au=Hunter%2C+Kent&rft.aulast=Hunter&rft.aufirst=Kent&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090418.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunologic signatures from the tumor microenvironment T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40356399; 5270670 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Marincola, Francesco Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Tumors KW - Microenvironments KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Immunologic+signatures+from+the+tumor+microenvironment&rft.au=Marincola%2C+Francesco&rft.aulast=Marincola&rft.aufirst=Francesco&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090418.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environment and occupational cancer research in the age of genomics T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40355704; 5270731 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Rothman, Nathaniel Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Age KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Environment+and+occupational+cancer+research+in+the+age+of+genomics&rft.au=Rothman%2C+Nathaniel&rft.aulast=Rothman&rft.aufirst=Nathaniel&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090418.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Re-issuance of EDRN T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40354733; 5274867 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Srivastava, Sudhir Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Re-issuance+of+EDRN&rft.au=Srivastava%2C+Sudhir&rft.aulast=Srivastava&rft.aufirst=Sudhir&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Introduction to NCI's glycomics initiative T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40354654; 5274858 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Srivastava, Sudhir Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Introduction+to+NCI%27s+glycomics+initiative&rft.au=Srivastava%2C+Sudhir&rft.aulast=Srivastava&rft.aufirst=Sudhir&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of miRNAs in human HCC T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40354224; 5275978 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Wang, Xin Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - MiRNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Role+of+miRNAs+in+human+HCC&rft.au=Wang%2C+Xin&rft.aulast=Wang&rft.aufirst=Xin&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090422.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of driver genes in human HCC T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40354193; 5275977 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Thorgeirsson, Snorri Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Identification+of+driver+genes+in+human+HCC&rft.au=Thorgeirsson%2C+Snorri&rft.aulast=Thorgeirsson&rft.aufirst=Snorri&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090422.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic risk factors for pancreatic cancer from genome-wide association studies T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40353700; 5275003 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Amundadottir, Laufey Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Pancreatic cancer KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40353700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Genetic+risk+factors+for+pancreatic+cancer+from+genome-wide+association+studies&rft.au=Amundadottir%2C+Laufey&rft.aulast=Amundadottir&rft.aufirst=Laufey&rft.date=2009-04-18&rft.volume=53&rft.issue=10&rft.spage=914&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/10.1016%2FS0006-3223%2802%2901677-3 L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tenure Track, Research Track T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40353678; 5273984 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Bailey, Lee Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40353678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Tenure+Track%2C+Research+Track&rft.au=Bailey%2C+Lee&rft.aulast=Bailey&rft.aufirst=Lee&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090420.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Survival Skills, Graduate Level T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40351941; 5273981 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Faupel-Badger, Jessica Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Survival+Skills%2C+Graduate+Level&rft.au=Faupel-Badger%2C+Jessica&rft.aulast=Faupel-Badger&rft.aufirst=Jessica&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090420.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular biology of breast cancer metastasis to the brain T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40351674; 5271737 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Steeg, Patricia Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Molecular biology KW - Brain KW - Breast cancer KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Molecular+biology+of+breast+cancer+metastasis+to+the+brain&rft.au=Steeg%2C+Patricia&rft.aulast=Steeg&rft.aufirst=Patricia&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090419.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Genetic Basis of Kidney Cancer: Disease Specific Approaches to Therapy T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40351610; 5274863 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Linehan, William Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Kidneys KW - Kidney diseases KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=The+Genetic+Basis+of+Kidney+Cancer%3A+Disease+Specific+Approaches+to+Therapy&rft.au=Linehan%2C+William&rft.aulast=Linehan&rft.aufirst=William&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of MDS mouse model T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40351270; 5275968 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Aplan, Peter Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Animal models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Development+of+MDS+mouse+model&rft.au=Aplan%2C+Peter&rft.aulast=Aplan&rft.aufirst=Peter&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NCI Cancer Therapy Evaluation Program: Therapeutics in the public interest T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40349857; 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5273902 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Collins, Jerry Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40349822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=The+NCI+Developmental+Therapeutics+Program%3A+From+molecules+to+medicines&rft.au=Collins%2C+Jerry&rft.aulast=Collins&rft.aufirst=Jerry&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090420.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular profiling: Insights into the pathogenesis of HCC T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40349142; 5275005 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Wang, Xin Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40349142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Molecular+profiling%3A+Insights+into+the+pathogenesis+of+HCC&rft.au=Wang%2C+Xin&rft.aulast=Wang&rft.aufirst=Xin&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Searching and downloading cancer genome data sets through TCGA Data Portal Data Access Matrix T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40348915; 5275958 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Schaefer, Carl Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Data processing KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Searching+and+downloading+cancer+genome+data+sets+through+TCGA+Data+Portal+Data+Access+Matrix&rft.au=Schaefer%2C+Carl&rft.aulast=Schaefer&rft.aufirst=Carl&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - State of the EDRN T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40348890; 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5272799 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Harris, Curtis Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Microenvironments KW - MiRNA KW - Cytokines KW - P53 protein KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Inflammation+and+cancer%3A+Microenvironment%2C+cytokines%2C+microRNA%2C+and+p53&rft.au=Harris%2C+Curtis&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090419.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Translating Cancer Biology into Cancer Medicine: IGFIR Ab Development in Sarcomas T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40348698; 5273997 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Helman, Lee Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Antibodies KW - Sarcoma KW - Insulin-like growth factor I receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychopathology+%2F+Giornale+di+Psicopatologia&rft.atitle=Comorbilit%C3%A0+psichiatrica+nell%27autismo+ad+alto+funzionamento%3A+Uno+studio+clinico&rft.au=De+Micheli%2C+A.+I.%3BFaggioli%2C+R.%3BBoso%2C+M.%3BBroglia%2C+D.%3BOrsi%2C+P.%3BDe+Vidovich%2C+G.%3BEmanuele%2C+E.%3BCaverzasi%2C+E.%3BPoliti%2C+P.%3BLenti%2C+C.%3BBarale%2C+F.&rft.aulast=De+Micheli&rft.aufirst=A.&rft.date=2012-12-01&rft.volume=18&rft.issue=4&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychopathology+%2F+Giornale+di+Psicopatologia&rft.issn=15921107&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Research Funding/Grant Opportunities, Postdoctoral Level T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40348662; 5273980 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Marino, Pamela Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Grants KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Research+Funding%2FGrant+Opportunities%2C+Postdoctoral+Level&rft.au=Marino%2C+Pamela&rft.aulast=Marino&rft.aufirst=Pamela&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090420.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The value for clinical and public health decisions of adding SNPs to a model to project breast cancer risk T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40348457; 5274888 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Gail, Mitchell Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Public health KW - Breast cancer KW - Single-nucleotide polymorphism KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Crop+science.&rft.atitle=Genetic+Mapping+of+Sheath+Blight+Resistance+QTLs+within+Tropical+Japonica+Rice+Cultivars&rft.au=Sharma%2C+Arun%3BMcClung%2C+Anna+M%3BPinson%2C+Shannon+R.M.%3BKepiro%2C+Joseph+L%3BShank%2C+A+Robert%3BTabien%2C+Rodante+E%3BFjellstrom%2C+Robert&rft.aulast=Sharma&rft.aufirst=Arun&rft.date=2009-01-01&rft.volume=49&rft.issue=1&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Crop+science.&rft.issn=0011183X&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cross-Talk of Innate Resistance and Immunity T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40348350; 5275963 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Trinchieri, Giorgio Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Immunity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Cross-Talk+of+Innate+Resistance+and+Immunity&rft.au=Trinchieri%2C+Giorgio&rft.aulast=Trinchieri&rft.aufirst=Giorgio&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using cancer genome data sets to examine mechanisms, targets, and outcomes in cancer T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40348028; 5275955 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Buetow, Kenneth Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Genomes KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Using+cancer+genome+data+sets+to+examine+mechanisms%2C+targets%2C+and+outcomes+in+cancer&rft.au=Das%2C+S+C%3BBalamohan%2C+T+N%3BPoornima%2C+K%3BSeenivasan%2C+N%3BVelalazan%2C+R%3BBergh%2C+I.+Van+den%3BWaele%2C+D+De&rft.aulast=Das&rft.aufirst=S&rft.date=2014-03-01&rft.volume=&rft.issue=1026&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Acta+horticulturae.&rft.issn=05677572&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammation and Cancer: Interweaving microRNA, Inflammatory Cytokine, and p53 Pathways T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40347645; 5275842 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Harris, Curtis Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Inflammation KW - Cytokines KW - MiRNA KW - P53 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Inflammation+and+Cancer%3A+Interweaving+microRNA%2C+Inflammatory+Cytokine%2C+and+p53+Pathways&rft.au=Harris%2C+Curtis&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NCI Cancer Imaging Program: Developing imaging tools for drug development T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40347379; 5273904 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Jacobs, Paula Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Drug development KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pest+management+science.&rft.atitle=Impact+of+insecticide-manipulated+defoliation+by+Japanese+beetle+%28Popillia+japonica%29+on+grapevines+from+vineyard+establishment+through+production&rft.au=Hammons%2C+Derrick+L%3BKaan+Kurtural%2C+S.%3BPotter%2C+Daniel+A&rft.aulast=Hammons&rft.aufirst=Derrick&rft.date=2010-05-01&rft.volume=66&rft.issue=5&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Pest+management+science.&rft.issn=1526498X&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090420.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A critical examination of the use of archived specimens for evaluating the medical utility of prognostic and predictive biomarkers T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40347143; 5272780 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Simon, Richard Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Bioindicators KW - Biomarkers KW - Prediction KW - Archives KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=A+critical+examination+of+the+use+of+archived+specimens+for+evaluating+the+medical+utility+of+prognostic+and+predictive+biomarkers&rft.au=Simon%2C+Richard&rft.aulast=Simon&rft.aufirst=Richard&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090419.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microbial natural products, derivatives, and mimics as antitumor agents T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40346852; 5275931 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Newman, David Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Natural products KW - Antitumor agents KW - Metabolites KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Microbial+natural+products%2C+derivatives%2C+and+mimics+as+antitumor+agents&rft.au=Newman%2C+David&rft.aulast=Newman&rft.aufirst=David&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - caBIGRG overview T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40346022; 5272901 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Klemm, Juli Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=caBIGRG+overview&rft.au=Klemm%2C+Juli&rft.aulast=Klemm&rft.aufirst=Juli&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090420.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanistic Discovery in Murine Cancer Models: From Basic Discovery to Clinical Translation T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40345888; 5273994 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Van Dyke, Terry Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Translation KW - Animal models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Mechanistic+Discovery+in+Murine+Cancer+Models%3A+From+Basic+Discovery+to+Clinical+Translation&rft.au=Van+Dyke%2C+Terry&rft.aulast=Van+Dyke&rft.aufirst=Terry&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NCI Alliance for Nanotechnology in Cancer: Challenges and opportunities T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40344211; 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5273937 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Staudt, Louis Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Lymphoma KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40344171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+horticulturae.&rft.atitle=Growers+can+reduce+sprays+during+control+of+Botryosphaeria+panicle+and+shoot+blight+of+pistachio+by+using+a+leaf+wetness+model&rft.au=Michailides%2C+T+J%3BMorgan%2C+D+P%3BPuckett%2C+R+D&rft.aulast=Michailides&rft.aufirst=T&rft.date=2014-03-01&rft.volume=&rft.issue=1028&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Acta+horticulturae.&rft.issn=05677572&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090420.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Introduction to Tumor Glycome Laboratories T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40343703; 5274859 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Krueger, Karl Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Introduction+to+Tumor+Glycome+Laboratories&rft.au=Krueger%2C+Karl&rft.aulast=Krueger&rft.aufirst=Karl&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090421.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - caIntegrator 2: Integrative analysis of translational research data T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40343034; 5272903 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Heiskanen, Mervi Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Translation KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=caIntegrator+2%3A+Integrative+analysis+of+translational+research+data&rft.au=Heiskanen%2C+Mervi&rft.aulast=Heiskanen&rft.aufirst=Mervi&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090420.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Update on the Collaborative's activities addressing the Critical Path T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40342814; 5272779 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Khleif, Samir Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Update+on+the+Collaborative%27s+activities+addressing+the+Critical+Path&rft.au=Khleif%2C+Samir&rft.aulast=Khleif&rft.aufirst=Samir&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090419.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Life sciences data and tools connected via caGrid T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40342697; 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5270780 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Terabe, Masaki Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Lymphocytes T KW - Immunoregulation KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=NKT+cells+and+cancer%3A+Two+subsets+form+a+new+immunoregulatory+axis&rft.au=Terabe%2C+Masaki&rft.aulast=Terabe&rft.aufirst=Masaki&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090418.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcisciplinary science, obesity and cancer: opportunities and perspective T2 - 2009 Conference on Experimental Biology AN - 40294402; 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5234960 JF - 2009 Conference on Experimental Biology AU - Milgram, S Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Mass spectroscopy KW - Channels KW - Ion channels KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40270432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=Identification+of+ion+channel+regulators+using+mass+spectrometry&rft.au=Milgram%2C+S&rft.aulast=Milgram&rft.aufirst=S&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Gene encoding erythrocyte binding ligand linked to blood stage multiplication rate phenotype in Plasmodium yoelii yoelii AN - 20772304; 10319836 AB - Variation in the multiplication rate of blood stage malaria parasites is often positively correlated with the severity of the disease they cause. The rodent malaria parasite Plasmodium yoelii yoelii has strains with marked differences in multiplication rate and pathogenicity in the blood. We have used genetic analysis by linkage group selection (LGS) to identify genes that determine differences in multiplication rate. Genetic crosses were generated between genetically unrelated, fast- (17XYM) and slowly multiplying (33XC) clones of P. y. yoelii. The uncloned progenies of these crosses were placed under multiplication rate selection in blood infections in mice. The selected progenies were screened for reduction in intensity of quantitative genetic markers of the slowly multiplying parent. A small number of strongly selected markers formed a linkage group on P. y. yoelii chromosome 13. Of these, that most strongly selected marked the gene encoding the P. yoelii erythrocyte binding ligand (pyebl), which has been independently identified by Otsuki and colleagues [Otsuki H, et al. (2009) Proc Natl Acad Sci USA 106:10.1073/pnas.0811313106] as a major determinant of virulence in these parasites. In an analysis of a previous genetic cross in P. y. yoelii, pyebl alleles of fast- and slowly multiplying parents segregated with the fast and slow multiplication rate phenotype in the cloned recombinant progeny, implying the involvement of the pyebl locus in determining the multiplication rate. Our genome-wide LGS analysis also indicated effects of at least 1 other locus on multiplication rate, as did the findings of Otsuki and colleagues on virulence in P. y. yoelii. JF - Proceedings of the National Academy of Sciences, USA AU - Pattaradilokrat, Sittiporn AU - Culleton, Richard L AU - Cheesman, Sandra J AU - Carter, Richard AD - Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom, pattaradilokrats@mail.nih.gov Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 SP - 7161 EP - 7166 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 17 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - erythrocyte binding ligand protein KW - rodent malaria KW - linkage group selection KW - virulence KW - Parasites KW - Human diseases KW - Group selection KW - Genetic analysis KW - Erythrocytes KW - Malaria KW - Infection KW - Phenotypes KW - Public health KW - Virulence KW - Alleles KW - Chromosomes KW - Pathogenicity KW - chromosome 13 KW - Endoparasites KW - Blood KW - USA KW - Linkage analysis KW - Genetic markers KW - Genetic crosses KW - Plasmodium yoelii yoelii KW - K 03410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20772304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Gene+encoding+erythrocyte+binding+ligand+linked+to+blood+stage+multiplication+rate+phenotype+in+Plasmodium+yoelii+yoelii&rft.au=Pattaradilokrat%2C+Sittiporn%3BCulleton%2C+Richard+L%3BCheesman%2C+Sandra+J%3BCarter%2C+Richard&rft.aulast=Pattaradilokrat&rft.aufirst=Sittiporn&rft.date=2009-04-18&rft.volume=106&rft.issue=17&rft.spage=7161&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0811430106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Blood; Chromosomes; Alleles; Human diseases; Erythrocytes; Malaria; Endoparasites; Phenotypes; Public health; chromosome 13; Group selection; Genetic analysis; Infection; Virulence; Linkage analysis; Pathogenicity; Genetic markers; Genetic crosses; Plasmodium yoelii yoelii; USA DO - http://dx.doi.org/10.1073/pnas.0811430106 ER - TY - JOUR T1 - Mechanisms of chiral discrimination by topoisomerase IV AN - 20241162; 10319806 AB - Topoisomerase IV (Topo IV), an essential ATP-dependent bacterial type II topoisomerase, transports one segment of DNA through a transient double-strand break in a second segment of DNA. In vivo, Topo IV unlinks catenated chromosomes before cell division and relaxes positive supercoils generated during DNA replication. In vitro, Topo IV relaxes positive supercoils at least 20-fold faster than negative supercoils. The mechanisms underlying this chiral discrimination by Topo IV and other type II topoisomerases remain speculative. We used magnetic tweezers to measure the relaxation rates of single and multiple DNA crossings by Topo IV. These measurements allowed us to determine unambiguously the relative importance of DNA crossing geometry and enzymatic processivity in chiral discrimination by Topo IV. Our results indicate that Topo IV binds and passes DNA strands juxtaposed in a nearly perpendicular orientation and that relaxation of negative supercoiled DNA is perfectly distributive. Together, these results suggest that chiral discrimination arises primarily from dramatic differences in the processivity of relaxing positive and negative supercoiled DNA: Topo IV is highly processive on positively supercoiled DNA, whereas it is perfectly distributive on negatively supercoiled DNA. These results provide fresh insight into topoisomerase mechanisms and lead to a model that reconciles contradictory aspects of previous findings while providing a framework to interpret future results. JF - Proceedings of the National Academy of Sciences, USA AU - Neuman, K C AU - Charvin, G AU - Bensimon, D AU - Croquette, V AD - Laboratoire de Physique Statistique, Ecole Normale Superieure, 75005 Paris, France, neumankc@nhlbi.nih.gov Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 SP - 6986 EP - 6991 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 17 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - DNA KW - magnetic tweezers KW - single molecule KW - topology KW - segregation KW - DNA biosynthesis KW - Cell division KW - Replication KW - DNA topoisomerase IV KW - J 02410:Animal Diseases KW - A 01490:Miscellaneous KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20241162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Mechanisms+of+chiral+discrimination+by+topoisomerase+IV&rft.au=Neuman%2C+K+C%3BCharvin%2C+G%3BBensimon%2C+D%3BCroquette%2C+V&rft.aulast=Neuman&rft.aufirst=K&rft.date=2009-04-18&rft.volume=106&rft.issue=17&rft.spage=6986&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0900574106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Cell division; Replication; DNA topoisomerase IV DO - http://dx.doi.org/10.1073/pnas.0900574106 ER - TY - JOUR T1 - A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. AN - 67129821; 18988862 AB - Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that combine a variable fragment (Fv) from an antibody to a tumor-associated antigen with a 38-kDa fragment of PE (PE38). The intoxication pathway of PE immunotoxins involves receptor-mediated internalization and trafficking through endosomes/lysosomes, during which the immunotoxin undergoes important proteolytic processing steps but must otherwise remain intact for eventual transport to the cytosol. We have investigated the proteolytic susceptibility of PE38 immunotoxins to lysosomal proteases and found that cleavage clusters within a limited segment of PE38. We subsequently generated mutants containing deletions in this region using HA22, an anti-CD22 Fv-PE38 immunotoxin currently undergoing clinical trials for B-cell malignancies. One mutant, HA22-LR, lacks all identified cleavage sites, is resistant to lysosomal degradation, and retains excellent biologic activity. HA22-LR killed chronic lymphocytic leukemia cells more potently and uniformly than HA22, suggesting that lysosomal protease digestion may limit immunotoxin efficacy unless the susceptible domain is eliminated. Remarkably, mice tolerated doses of HA22-LR at least 10-fold higher than lethal doses of HA22, and these higher doses exhibited markedly enhanced antitumor activity. We conclude that HA22-LR advances the therapeutic efficacy of HA22 by using an approach that may be applicable to other PE-based immunotoxins. JF - Blood AU - Weldon, John E AU - Xiang, Laiman AU - Chertov, Oleg AU - Margulies, Inger AU - Kreitman, Robert J AU - FitzGerald, David J AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4264, USA. Y1 - 2009/04/16/ PY - 2009 DA - 2009 Apr 16 SP - 3792 EP - 3800 VL - 113 IS - 16 KW - Antibodies, Monoclonal KW - 0 KW - Bacterial Toxins KW - CD22 protein, human KW - Cd22 protein, mouse KW - Exotoxins KW - Immunoglobulin Variable Region KW - Immunotoxins KW - Sialic Acid Binding Ig-like Lectin 2 KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Humans KW - Clinical Trials as Topic KW - Mice, Nude KW - Mice KW - Lysosomes -- metabolism KW - Endosomes -- metabolism KW - Mice, Inbred BALB C KW - Mutation KW - Female KW - Antibodies, Monoclonal -- genetics KW - ADP Ribose Transferases -- adverse effects KW - Exotoxins -- adverse effects KW - Antibodies, Monoclonal -- pharmacology KW - ADP Ribose Transferases -- pharmacology KW - Leukemia, Lymphocytic, Chronic, B-Cell -- metabolism KW - ADP Ribose Transferases -- genetics KW - Bacterial Toxins -- genetics KW - Bacterial Toxins -- adverse effects KW - Immunoglobulin Variable Region -- pharmacology KW - Xenograft Model Antitumor Assays KW - Immunotoxins -- genetics KW - Immunoglobulin Variable Region -- genetics KW - Immunotoxins -- pharmacokinetics KW - Exotoxins -- genetics KW - Exotoxins -- pharmacology KW - ADP Ribose Transferases -- pharmacokinetics KW - Immunoglobulin Variable Region -- adverse effects KW - Immunotoxins -- adverse effects KW - Virulence Factors -- genetics KW - Bacterial Toxins -- pharmacology KW - Exotoxins -- pharmacokinetics KW - Virulence Factors -- pharmacology KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Bacterial Toxins -- pharmacokinetics KW - Antibodies, Monoclonal -- pharmacokinetics KW - Antibodies, Monoclonal -- adverse effects KW - Immunotoxins -- pharmacology KW - Virulence Factors -- pharmacokinetics KW - Virulence Factors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67129821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=A+protease-resistant+immunotoxin+against+CD22+with+greatly+increased+activity+against+CLL+and+diminished+animal+toxicity.&rft.au=Weldon%2C+John+E%3BXiang%2C+Laiman%3BChertov%2C+Oleg%3BMargulies%2C+Inger%3BKreitman%2C+Robert+J%3BFitzGerald%2C+David+J%3BPastan%2C+Ira&rft.aulast=Weldon&rft.aufirst=John&rft.date=2009-04-16&rft.volume=113&rft.issue=16&rft.spage=3792&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2008-08-173195 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-15 N1 - Date created - 2009-04-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2000 Apr;6(4):1476-87 [10778980] J Clin Oncol. 2000 Apr;18(8):1622-36 [10764422] Blood. 1994 Jan 15;83(2):426-34 [8286741] Cancer Res. 1994 May 15;54(10):2714-8 [8168102] J Biol Chem. 1994 Jul 8;269(27):18167-76 [8027078] Bioconjug Chem. 1994 Nov-Dec;5(6):532-8 [7873657] Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):974-8 [8577771] Semin Cancer Biol. 1996 Apr;7(2):87-95 [8740564] Biochemistry. 1997 Nov 25;36(47):14577-82 [9398176] Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):669-74 [9435250] Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4516-21 [9539769] Immunity. 1999 Feb;10(2):197-206 [10072072] Immunity. 1999 Feb;10(2):207-17 [10072073] Int J Cancer. 1999 Mar 31;81(1):148-55 [10077166] Mol Microbiol. 1999 Mar;31(5):1385-93 [10200959] Clin Cancer Res. 2005 Feb 15;11(4):1545-50 [15746059] J Biol Chem. 2005 Jun 3;280(22):21194-201 [15799975] J Clin Oncol. 2005 Sep 20;23(27):6719-29 [16061911] Biochim Biophys Acta. 2005 Sep 25;1741(3):234-9 [16095885] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Annu Rev Med. 2007;58:221-37 [17059365] Cell Res. 2007 Feb;17(2):89-99 [17242688] Clin Cancer Res. 2007 Sep 1;13(17):5144-9 [17785569] Blood. 2008 Jan 1;111(1):338-43 [17895404] Curr Protoc Cell Biol. 2005 Jul;Chapter 15:Unit 15.8 [18228463] Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11311-6 [18678888] J Immunol. 2000 Dec 15;165(12):7150-6 [11120846] Cancer Res. 2001 Jul 1;61(13):5070-7 [11431343] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] J Mol Biol. 2001 Dec 7;314(4):823-37 [11734000] Eur J Immunol. 2002 Feb;32(2):467-76 [11813165] Clin Cancer Res. 2002 Apr;8(4):995-1002 [11948105] Leukemia. 2002 Sep;16(9):1868-70 [12200708] Methods Mol Biol. 2004;248:503-18 [14970517] Am J Physiol. 1978 Jun;234(6):F455-60 [665772] Proc Natl Acad Sci U S A. 1986 Mar;83(5):1320-4 [3006045] Cell. 1987 Jan 16;48(1):129-36 [3098436] J Biol Chem. 1989 Aug 25;264(24):14256-61 [2503515] J Biol Chem. 1989 Sep 25;264(27):15953-9 [2506173] Eur J Biochem. 1990 Sep 11;192(2):379-85 [2170123] J Biol Chem. 1990 Nov 25;265(33):20678-85 [2122978] Mol Cell Biol. 1991 Mar;11(3):1751-3 [1671711] Biochemistry. 1992 Apr 14;31(14):3555-9 [1567815] J Biol Chem. 1992 Jun 25;267(18):12420-3 [1618748] J Immunol. 1999 Dec 1;163(11):6072-7 [10570296] Biochemistry. 1999 Dec 14;38(50):16507-13 [10600112] Immunology. 2000 May;100(1):13-20 [10809954] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2008-08-173195 ER - TY - CONF T1 - Current status and future potential of advanced technologies in radiation oncology. Part 2. State of the science by anatomic site. AN - 67290165; 19476269 AB - In December 2006, the Radiation Research Program of the Division of Cancer Treatment and Diagnosis of the National Cancer Institute hosted a workshop intended to address current issues related to advanced radiation therapy technologies, with an eye toward (1) defining the specific toxicities that have limited the success of "conventional" radiation therapy, (2) examining the evidence from phase III studies for the improvements attributed to the advanced technologies in the treatment of several cancers commonly treated with radiation therapy, and (3) determining the opportunities and priorities for further technologic development and clinical trials. The new technologies offer substantial theoretical advantage in radiation dose distributions that, if realized in clinical practice, may help many cancer patients live longer and/or better. The precision of the advanced technologies may allow us to reduce the volume of normal tissue irradiated in the vicinity of the clinical target volume. Part 1 of this two-part article, which appeared in the March issue of ONCOLOGY, provided a general overview of the workshop discussion, focusing on the challenges posed by the new technologies and resources available or in development for meeting those challenges. This month, part 2 will outline the state of the science for each disease site. JF - Oncology (Williston Park, N.Y.) AU - Vikram, Bhadrasain AU - Coleman, C Norman AU - Deye, James A Y1 - 2009/04/15/ PY - 2009 DA - 2009 Apr 15 SP - 380 EP - 385 VL - 23 IS - 4 KW - Index Medicus KW - United States KW - Radiotherapy Planning, Computer-Assisted KW - Nasopharyngeal Neoplasms -- radiotherapy KW - Glioblastoma -- radiotherapy KW - Clinical Trials, Phase III as Topic KW - Humans KW - Radiotherapy, Adjuvant -- adverse effects KW - Breast Neoplasms -- radiotherapy KW - Brain Neoplasms -- secondary KW - National Cancer Institute (U.S.) KW - Radiotherapy Dosage KW - Brain Neoplasms -- radiotherapy KW - Treatment Outcome KW - Female KW - Male KW - Prostatic Neoplasms -- radiotherapy KW - Neoplasms -- pathology KW - Neoplasms -- radiotherapy KW - Radiation Oncology -- trends KW - Radiation Injuries -- prevention & control KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67290165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Oncology+%28Williston+Park%2C+N.Y.%29&rft.atitle=Current+status+and+future+potential+of+advanced+technologies+in+radiation+oncology.+Part+2.+State+of+the+science+by+anatomic+site.&rft.au=Vikram%2C+Bhadrasain%3BColeman%2C+C+Norman%3BDeye%2C+James+A&rft.aulast=Vikram&rft.aufirst=Bhadrasain&rft.date=2009-04-15&rft.volume=23&rft.issue=4&rft.spage=380&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Williston+Park%2C+N.Y.%29&rft.issn=08909091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-19 N1 - Date created - 2009-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Oncology (Williston Park). 2009 Apr 15;23(4):390, 393 [19476271] Oncology (Williston Park). 2009 Apr 15;23(4):386, 389 [19476270] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells. AN - 67127055; 19351856 AB - Limited information is available about epigenetic mechanisms by which cigarette smoke enhances the initiation and progression of lung cancer. To examine this issue, A549 and Calu-6 lung cancer cells were cultured in normal media with or without tobacco smoke condensate (TSC) under clinically relevant exposure conditions. Ten-day TSC exposure dramatically increased the tumorigenicity of lung cancer cells in nude mice. Microarray and quantitative reverse transcription-PCR (RT-PCR) experiments revealed that this phenomenon coincided with diminished expression of Dickkopf-1 (Dkk-1). Western blot, chromatin immunoprecipitation, methylation-specific PCR, and pyrosequencing experiments showed that repression of Dkk-1 coincided with decreased H4K16Ac, increased H3K27me3, and recruitment of SirT1, EZH2, SUZ12, and Bmi1 without DNA hypermethylation within the Dkk-1 promoter despite prolonged TSC exposures. Removal of TSC from culture media resulted in loss of promoter-associated polycomb repressor complexes and reexpression of Dkk-1. siRNA-mediated knockdown of EZH2 and SirT1 partially abrogated TSC-mediated inhibition of Dkk-1 expression. Western blot and quantitative RT-PCR array experiments showed that TSC exposure as well as knockdown of Dkk-1 activated Wnt signaling and significantly up-regulated Wnt5a in lung cancer cells. Knockdown of Dkk-1 recapitulated the dramatic protumorigenic effects of TSC exposure in Calu-6 cells. Despite the transient nature of Dkk-1 repression following TSC exposure in vitro, Dkk-1 remained silenced in tumor xenografts derived from TSC-treated Calu-6 cells. Collectively, these data provide evidence that cigarette smoke directly engages polycomb machinery to activate a signaling network implicated in maintenance of cancer stem cells. JF - Cancer research AU - Hussain, Mustafa AU - Rao, Mahadev AU - Humphries, Ashley E AU - Hong, Julie A AU - Liu, Fang AU - Yang, Maocheng AU - Caragacianu, Diana AU - Schrump, David S AD - Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1201, USA. Y1 - 2009/04/15/ PY - 2009 DA - 2009 Apr 15 SP - 3570 EP - 3578 VL - 69 IS - 8 KW - DKK1 protein, human KW - 0 KW - DNA-Binding Proteins KW - Intercellular Signaling Peptides and Proteins KW - Polycomb-Group Proteins KW - RNA, Small Interfering KW - Repressor Proteins KW - Smoke KW - Transcription Factors KW - Wnt Proteins KW - EZH2 protein, human KW - EC 2.1.1.43 KW - Enhancer of Zeste Homolog 2 Protein KW - Polycomb Repressive Complex 2 KW - SIRT1 protein, human KW - EC 3.5.1.- KW - Sirtuin 1 KW - Sirtuins KW - Index Medicus KW - Animals KW - Humans KW - DNA-Binding Proteins -- genetics KW - RNA, Small Interfering -- genetics KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Transcription Factors -- genetics KW - Wnt Proteins -- metabolism KW - Acetylation KW - Gene Expression Profiling KW - Promoter Regions, Genetic KW - DNA Methylation KW - Down-Regulation KW - Sirtuins -- genetics KW - Transplantation, Heterologous KW - Signal Transduction KW - Tobacco -- toxicity KW - Intercellular Signaling Peptides and Proteins -- genetics KW - Repressor Proteins -- biosynthesis KW - Lung Neoplasms -- etiology KW - Tobacco -- chemistry KW - Repressor Proteins -- metabolism KW - Lung Neoplasms -- genetics KW - Intercellular Signaling Peptides and Proteins -- biosynthesis KW - Repressor Proteins -- genetics KW - Intercellular Signaling Peptides and Proteins -- metabolism KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67127055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Tobacco+smoke+induces+polycomb-mediated+repression+of+Dickkopf-1+in+lung+cancer+cells.&rft.au=Hussain%2C+Mustafa%3BRao%2C+Mahadev%3BHumphries%2C+Ashley+E%3BHong%2C+Julie+A%3BLiu%2C+Fang%3BYang%2C+Maocheng%3BCaragacianu%2C+Diana%3BSchrump%2C+David+S&rft.aulast=Hussain&rft.aufirst=Mustafa&rft.date=2009-04-15&rft.volume=69&rft.issue=8&rft.spage=3570&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-2807 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-19 N1 - Date created - 2009-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-2807 ER - TY - JOUR T1 - Detection of precancerous cervical lesions is differential by human papillomavirus type. AN - 67124359; 19351830 AB - Epidemiologic studies have reported the underrepresentation of cervical precancerous lesions caused by human papillomavirus (HPV) types 18 and 45 (HPV18/45) compared with the proportion of cervical cancers attributed to these HPV types. We investigated the timing of diagnosis of histologic cervical intraepithelial neoplasia grade 3 or worse (CIN3+) using data from the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study (ALTS). Of the 2,725 women who underwent enrollment colposcopy, 412 of 472 (87.3%) diagnosed with histologic CIN3+ over the 2-year duration of ALTS could be assigned to a HPV type or group of types and were included in this analysis. Eighty-four percent of HPV16-positive CIN3+ were diagnosed at enrollment, compared with 57% of HPV18/45-positive CIN3+, and 58% of CIN3 positive for other carcinogenic HPV types at enrollment. In contrast, only 8% of HPV16-positive CIN3+ were diagnosed at exit, whereas 31% were HPV18/45 positive and 22% were positive for other carcinogenic types at study exit (P < 0.001). These results indicate the underrepresentation of HPV18/45 in precancers, whereas HPV16-associated CIN3+ is diagnosed much earlier. Whether the underrepresentation of 18/45 may be due to occult pathology needs further investigation. JF - Cancer research AU - Safaeian, Mahboobeh AU - Schiffman, Mark AU - Gage, Julia AU - Solomon, Diane AU - Wheeler, Cosette M AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA. safaeianm@mail.nih.gov Y1 - 2009/04/15/ PY - 2009 DA - 2009 Apr 15 SP - 3262 EP - 3266 VL - 69 IS - 8 KW - Index Medicus KW - Humans KW - Vaginal Smears KW - Female KW - Colposcopy KW - Papillomavirus Infections -- pathology KW - Cervical Intraepithelial Neoplasia -- pathology KW - Carcinoma, Squamous Cell -- diagnosis KW - Human papillomavirus 16 -- isolation & purification KW - Carcinoma, Squamous Cell -- pathology KW - Uterine Cervical Neoplasms -- diagnosis KW - Papillomavirus Infections -- virology KW - Human papillomavirus 18 -- isolation & purification KW - Cervical Intraepithelial Neoplasia -- virology KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Uterine Cervical Neoplasms -- pathology KW - Carcinoma, Squamous Cell -- virology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67124359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Detection+of+precancerous+cervical+lesions+is+differential+by+human+papillomavirus+type.&rft.au=Safaeian%2C+Mahboobeh%3BSchiffman%2C+Mark%3BGage%2C+Julia%3BSolomon%2C+Diane%3BWheeler%2C+Cosette+M%3BCastle%2C+Philip+E&rft.aulast=Safaeian&rft.aufirst=Mahboobeh&rft.date=2009-04-15&rft.volume=69&rft.issue=8&rft.spage=3262&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-4192 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-19 N1 - Date created - 2009-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Obstet Gynecol. 2008 Apr;111(4):847-56 [18378743] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] J Natl Cancer Inst. 2000 Mar 1;92(5):397-402 [10700419] Acta Cytol. 2000 Sep-Oct;44(5):726-42 [11015972] J Natl Cancer Inst. 2001 Feb 21;93(4):293-9 [11181776] J Infect Dis. 2001 Jun 1;183(11):1554-64 [11343204] Br J Cancer. 2003 Jan 13;88(1):63-73 [12556961] Am J Obstet Gynecol. 2003 Jun;188(6):1383-92 [12824967] Am J Obstet Gynecol. 2003 Jun;188(6):1393-400 [12824968] Br J Cancer. 2003 Jul 7;89(1):101-5 [12838308] Am J Obstet Gynecol. 2007 Jul;197(1):47.e1-8 [17618753] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] Obstet Gynecol. 1992 Mar;79(3):328-37 [1310805] Virology. 2005 Jun 20;337(1):76-84 [15914222] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Obstet Gynecol. 2006 Aug;108(2):264-72 [16880294] Cancer Res. 2006 Oct 15;66(20):10112-9 [17047075] Comment In: Cancer Res. 2010 Mar 1;70(5):2136; author reply 2136 [20179199] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-4192 ER - TY - JOUR T1 - Translating the metastasis paradigm from scientific theory to clinical oncology. AN - 67123368; 19351761 AB - Cancer metastasis contributes to significant morbidity and mortality. Patients with metastatic cancer, often considered incurable, are provided with either supportive care or aggressive management without curative intent. Despite decades of research toward unraveling cancer progression mechanisms, the current body of knowledge has not translated into effective antimetastasis therapies, but recent findings challenge the classic notion that metastases develop during the late stages of carcinogenesis. Here, we evaluate the scientific evidence in the context of the multistage metastasis model. The resolution of current controversies has implications on both the prognostic value of molecular technology and the future of targeted therapies for the clinical benefit of metastasis patients. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Dong, Fei AU - Budhu, Anuradha S AU - Wang, Xin Wei AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20902, USA. Y1 - 2009/04/15/ PY - 2009 DA - 2009 Apr 15 SP - 2588 EP - 2593 VL - 15 IS - 8 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - Intercellular Signaling Peptides and Proteins KW - Index Medicus KW - Signal Transduction -- physiology KW - Animals KW - Intercellular Signaling Peptides and Proteins -- immunology KW - Humans KW - Signal Transduction -- drug effects KW - Models, Biological KW - Intercellular Signaling Peptides and Proteins -- metabolism KW - Antibodies, Monoclonal -- therapeutic use KW - Neoplasm Metastasis -- therapy KW - Neoplasm Metastasis -- physiopathology KW - Neoplasm Metastasis -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67123368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Translating+the+metastasis+paradigm+from+scientific+theory+to+clinical+oncology.&rft.au=Dong%2C+Fei%3BBudhu%2C+Anuradha+S%3BWang%2C+Xin+Wei&rft.aulast=Dong&rft.aufirst=Fei&rft.date=2009-04-15&rft.volume=15&rft.issue=8&rft.spage=2588&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-08-2356 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-04 N1 - Date created - 2009-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Metastasis Rev. 1989 Aug;8(2):98-101 [2673568] Cancer Res. 2008 Mar 1;68(5):1451-61 [18316609] Br J Cancer. 1997;76(5):628-33 [9303362] N Engl J Med. 2004 Nov 18;351(21):2159-69 [15548776] Nature. 2005 Jul 28;436(7050):518-24 [16049480] J Clin Oncol. 2005 Sep 20;23(27):6657-63 [16170173] Semin Oncol. 2005 Dec;32(6 Suppl 9):S43-7 [16399431] Nat Rev Cancer. 2006 Feb;6(2):141-6 [16491073] Cancer Cell. 2006 Aug;10(2):99-111 [16904609] Nature. 2007 Apr 12;446(7137):765-70 [17429393] Cancer. 2007 Aug 1;110(3):581-9 [17583545] Cancer. 2007 Sep 1;110(5):1059-67 [17623837] Cancer Metastasis Rev. 2007 Dec;26(3-4):373-400 [17717638] Cancer. 2008 Jan 15;112(2):250-9 [18041064] Cancer Cell. 2008 Jan;13(1):58-68 [18167340] Hepatology. 2008 Mar;47(3):897-907 [18176954] Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4283-8 [18337506] Nat Rev Immunol. 2008 Jul;8(7):523-32 [18566595] N Engl J Med. 2008 Jul 24;359(4):378-90 [18650514] Nature. 2008 Jul 24;454(7203):436-44 [18650914] Curr Oncol Rep. 2008 May;10(3):199-205 [18765149] Gastroenterology. 2009 Mar;136(3):1012-24 [19150350] Cell. 2000 Jan 7;100(1):57-70 [10647931] Nature. 2000 Aug 3;406(6795):532-5 [10952316] Nature. 2000 Aug 17;406(6797):747-52 [10963602] Nature. 2001 Nov 1;414(6859):105-11 [11689955] Eur J Cancer. 2002 Feb;38(3):409-13 [11818207] Nature. 2002 Jan 31;415(6871):530-6 [11823860] Nat Rev Cancer. 2002 Jun;2(6):442-54 [12189386] Nature. 2002 Aug 22;418(6900):823 [12192390] N Engl J Med. 2002 Dec 19;347(25):1999-2009 [12490681] Nat Genet. 2003 Jan;33(1):49-54 [12469122] Nat Med. 2003 Apr;9(4):416-23 [12640447] Cancer Cell. 2003 Jun;3(6):537-49 [12842083] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15901-5 [14665696] Nat Rev Cancer. 2004 Jan;4(1):71-8 [14708027] Hepatology. 2004 Mar;39(3):792-7 [14999698] Virchows Arch A Pathol Anat Histol. 1975;365(2):91-101 [804747] Science. 1977 Aug 26;197(4306):893-5 [887927] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597] Cancer Res. 2007 Nov 15;67(22):10831-9 [18006828] Cancer Res. 2007 Dec 15;67(24):11476-9; discussion 11479-80 [18089773] Cancer. 1995 May 1;75(9):2214-9 [7536120] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-08-2356 ER - TY - JOUR T1 - A finite mixture survival model to characterize risk groups of neuroblastoma. AN - 67049383; 19184977 AB - Neuroblastoma is a childhood cancer with patients experiencing heterogeneous survival outcomes despite aggressive treatment. Disease outcomes range from early death to spontaneous regression of the tumor followed by cure. Owing to this heterogeneity, it is of interest to identify patients with similar types of neuroblastoma so that specific types of treatment can be developed. Oncologists are especially interested in identifying patients who will be cured so that the minimum amount of a potentially toxic treatment can be given to this group of patients. We analyze a large cohort of neuroblastoma patients and develop a finite mixture model that uses covariates to predict the probability of being in a cure group or other (one or more) risk groups. A prediction method is developed that uses the estimated probabilities to assign a patient to different risk groups. The robustness of the model and the prediction method is examined via simulation by looking at misclassification rates under misspecified models. JF - Statistics in medicine AU - Hunsberger, Sally AU - Albert, Paul S AU - London, Wendy B AD - Biometric Research Branch, National Cancer Institute, 6130 Executive Boulevard, Rm 8120, Rockville, MD 20852, USA. sallyh@ctep.nci.nih.gov Y1 - 2009/04/15/ PY - 2009 DA - 2009 Apr 15 SP - 1301 EP - 1314 VL - 28 IS - 8 SN - 0277-6715, 0277-6715 KW - Index Medicus KW - Infant KW - Neoplasm Staging KW - Age of Onset KW - Genes, myc KW - Humans KW - Cohort Studies KW - Child KW - Survival Analysis KW - Child, Preschool KW - Neuroblastoma -- pathology KW - Neuroblastoma -- genetics KW - Neuroblastoma -- therapy KW - Models, Statistical KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67049383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+medicine&rft.atitle=A+finite+mixture+survival+model+to+characterize+risk+groups+of+neuroblastoma.&rft.au=Hunsberger%2C+Sally%3BAlbert%2C+Paul+S%3BLondon%2C+Wendy+B&rft.aulast=Hunsberger&rft.aufirst=Sally&rft.date=2009-04-15&rft.volume=28&rft.issue=8&rft.spage=1301&rft.isbn=&rft.btitle=&rft.title=Statistics+in+medicine&rft.issn=02776715&rft_id=info:doi/10.1002%2Fsim.3543 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-20 N1 - Date created - 2009-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/sim.3543 ER - TY - CPAPER T1 - Craniofacial resection for malignant tumours involving the anterior skull base T2 - 9th Congress of the European Skull Base Society (ESBS 2009) AN - 41883862; 5098834 JF - 9th Congress of the European Skull Base Society (ESBS 2009) AU - Cantu, G AU - Riccio, S AU - Solero, C Y1 - 2009/04/15/ PY - 2009 DA - 2009 Apr 15 KW - Skull KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41883862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Congress+of+the+European+Skull+Base+Society+%28ESBS+2009%29&rft.atitle=Craniofacial+resection+for+malignant+tumours+involving+the+anterior+skull+base&rft.au=Cantu%2C+G%3BRiccio%2C+S%3BSolero%2C+C&rft.aulast=Cantu&rft.aufirst=G&rft.date=2009-04-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Congress+of+the+European+Skull+Base+Society+%28ESBS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.esbs2009.eu/Media/documenten/scientific_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cause-Specific Mortality in Long-Term Survivors of Retinoblastoma AN - 20593789; 9300767 AB - Background Subsequent malignant neoplasms are a major cause of premature death in survivors of hereditary retinoblastoma. Radiotherapy further increases the risk of death. Mortality information is limited among long-term survivors who were irradiated for hereditary retinoblastoma.Methods We examined cause-specific mortality among 1854 retinoblastoma survivors who were diagnosed from January 1, 1914, through December 31, 1996, at two US institutions. Standardized mortality ratios (SMRs) were calculated by use of US mortality data to estimate expected numbers of deaths. The relative rates (RRs) of mortality due to subsequent malignant neoplasms associated with multiple risk factors were evaluated with Poisson regression models. Cumulative mortality from subsequent malignant neoplasms was calculated by treating other causes of death as competing risks.Results A total of 151 deaths due to subsequent malignant neoplasms occurred among 1092 hereditary retinoblastoma survivors (SMR = 35, 95% confidence interval [CI] = 30 to 41) compared with 12 deaths among 762 nonhereditary retinoblastoma survivors (SMR = 2.5, 95% CI = 1.3 to 4.4). In this extended follow-up of retinoblastoma survivors, we found no evidence of excess mortality from non-neoplastic causes compared with the general population. However, excess mortality from subsequent malignant neoplasms (particularly sarcomas, melanomas, and cancers of the brain and other parts of the nervous system) among hereditary retinoblastoma survivors extended beyond 40 years after retinoblastoma diagnosis. The additional 13 years of follow-up since our last mortality study revealed a previously unreported increased risk of death due to cancers of the corpus uteri (primarily sarcomas) and confirmed the previously reported elevated risk of death from lung cancer among hereditary retinoblastoma survivors. Among hereditary and nonhereditary retinoblastoma survivors, the relative rates of mortality from subsequent malignant neoplasm were higher in those who had been treated with radiotherapy than in those who had not. Cumulative mortality from subsequent malignant neoplasms at 50 years after retinoblastoma diagnosis was 25.5% (95% CI = 20.8% to 30.2%) for hereditary retinoblastoma survivors and 1.0% (95% CI = 0.2% to 1.8%) for nonhereditary retinoblastoma survivors.Conclusions The temporal patterns of site-specific excess risks of subsequent malignant neoplasms in retinoblastoma survivors should inform screening programs designed for the early detection and treatment of subsequent malignant neoplasms. JF - Journal of the National Cancer Institute AU - Yu, Chu-Ling AU - Tucker, Margaret A AU - Abramson, David H AU - Furukawa, Kyoji AU - Seddon, Johanna M AU - Stovall, Marilyn AU - Fraumeni, Joseph F AU - Kleinerman, Ruth A AD - Affiliations of authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD (C-LY, MAT, JFF, RAK); Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY (DHA); Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan (KF); Ophthalmic Epidemiology & Genetics Service, Tufts-New England Medical Center, Boston, MA (JMS); Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (MS), yuchu@mail.nih.gov Y1 - 2009/04/15/ PY - 2009 DA - 2009 Apr 15 SP - 581 EP - 591 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 101 IS - 8 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - Brain KW - Standards KW - melanoma KW - radiotherapy KW - Cancer KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20593789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Cause-Specific+Mortality+in+Long-Term+Survivors+of+Retinoblastoma&rft.au=Yu%2C+Chu-Ling%3BTucker%2C+Margaret+A%3BAbramson%2C+David+H%3BFurukawa%2C+Kyoji%3BSeddon%2C+Johanna+M%3BStovall%2C+Marilyn%3BFraumeni%2C+Joseph+F%3BKleinerman%2C+Ruth+A&rft.aulast=Yu&rft.aufirst=Chu-Ling&rft.date=2009-04-15&rft.volume=101&rft.issue=8&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Brain; Standards; melanoma; radiotherapy; Cancer; Lung cancer DO - http://dx.doi.org/10.1093/jnci/djp046 ER - TY - JOUR T1 - Lung Cancer and Chronic Obstructive Pulmonary Disease: Needs and Opportunities for Integrated Research AN - 20588446; 9300778 AB - Lung cancer and chronic obstructive pulmonary disease (COPD) are leading causes of morbidity and mortality in the United States and worldwide. They share a common environmental risk factor in cigarette smoke exposure and a genetic predisposition represented by the incidence of these diseases in only a fraction of smokers. The presence of COPD increases the risk of lung cancer up to 4.5-fold. To investigate commonalities in disease mechanisms and perspectives for disease chemoprevention, the National Heart, Lung, and Blood Institute (NHLBI) and the National Cancer Institute (NCI) held a workshop. The participants identified four research objectives: 1) clarify common epidemiological characteristics of lung cancer and COPD; 2) identify shared genetic and epigenetic risk factors; 3) identify and validate biomarkers, molecular signatures, and imaging-derived measurements of each disease; and 4) determine common and disparate pathogenetic mechanisms. These objectives should be reached via four research approaches: 1) identify, publicize, and enable the evaluation and analysis of existing datasets and repositories of biospecimens; 2) obtain phenotypic and outcome data and biospecimens from large studies of subjects with and/or at risk for COPD and lung cancer; 3) develop and use animal and other preclinical models to investigate pathogenetic links between the diseases; and 4) conduct early-phase clinical trials of potential chemopreventive agents. To foster much needed research interactions, two final recommendations were made by the participants: 1) incorporate baseline phenotyping and outcome measures for both diseases in future longitudinal studies of each disease and 2) expand collaborative efforts between the NCI and NHLBI. JF - Journal of the National Cancer Institute AU - Punturieri, Antonello AU - Szabo, Eva AU - Croxton, Thomas L AU - Shapiro, Steven D AU - Dubinett, Steven M AD - Affiliations of authors: Division of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, MD (AP, TLC); Division of Cancer Prevention, National Cancer Institute, Bethesda, MD (ES); Department of Medicine, University of Pittsburgh, Pittsburgh, PA (SDS); David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, CA (SMD), punturieria@nhlbi.nih.gov Y1 - 2009/04/15/ PY - 2009 DA - 2009 Apr 15 SP - 554 EP - 559 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 101 IS - 8 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Bioindicators KW - Smoke KW - Mortality KW - USA KW - clinical trials KW - Cancer KW - Morbidity KW - longitudinal studies KW - chemotherapy KW - Lung cancer KW - chronic obstructive pulmonary disease KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Lung+Cancer+and+Chronic+Obstructive+Pulmonary+Disease%3A+Needs+and+Opportunities+for+Integrated+Research&rft.au=Punturieri%2C+Antonello%3BSzabo%2C+Eva%3BCroxton%2C+Thomas+L%3BShapiro%2C+Steven+D%3BDubinett%2C+Steven+M&rft.aulast=Punturieri&rft.aufirst=Antonello&rft.date=2009-04-15&rft.volume=101&rft.issue=8&rft.spage=554&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoke; Bioindicators; Mortality; clinical trials; chemotherapy; longitudinal studies; Morbidity; Cancer; chronic obstructive pulmonary disease; Lung cancer; USA DO - http://dx.doi.org/10.1093/jnci/djp023 ER - TY - JOUR T1 - g-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin AN - 20465564; 9165804 AB - Ionizing radiation (IR) exposure is inevitable in our modern society and can lead to a variety of deleterious effects including cancer and birth defects. A reliable, reproducible and sensitive assessment of exposure to IR and the individual response to that exposure would provide much needed information for the optimal treatment of each donor examined. We have developed a diagnostic test for IR exposure based on detection of the phosphorylated form of variant histone H2AX (g-H2AX), which occurs specifically at sites of DNA double-strand breaks (DSBs). The cell responds to a nascent DSB through the phosphorylation of thousands of H2AX molecules flanking the damaged site. This highly amplified response can be visualized as a g-H2AX focus in the chromatin that can be detected in situ with the appropriate antibody. Here we assess the usability of g-H2AX focus formation as a possible biodosimeter for human exposure to IR using peripheral blood lymphocytes irradiated ex vivo and three-dimensional artificial models of human skin biopsies. In both systems, the tissues were exposed to 0.2-5Gy, doses of IR that might be realistically encountered in various scenarios such as cancer radiotherapies or accidental exposure to radiation. Since the g-H2AX response is maximal 30min after exposure and declines over a period of hours as the cells repair the damage, we examined the time limitations of the useful detectability of g-H2AX foci. We report that a linear response proportional to the initial radiation dose was obtained 48 and 24h after exposure in blood samples and skin cells respectively. Thus, detection of g-H2AX formation to monitor DNA damage in minimally invasive blood and skin tests could be useful tools to determine radiation dose exposure and analyze its effects on humans. JF - Advances in Space Research AU - Redon, CE AU - Dickey, J S AU - Bonner, WM AU - Sedelnikova, O A AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, D.H.H.S., Bethesda, MD 20892, USA, redonc@mail.nih.gov Y1 - 2009/04/15/ PY - 2009 DA - 2009 Apr 15 SP - 1171 EP - 1178 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 43 IS - 8 SN - 0273-1177, 0273-1177 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Meteorological & Geoastrophysical Abstracts KW - Skin KW - Chromatin KW - Radiotherapy KW - Biopsy KW - Peripheral blood KW - Lymphocytes KW - biomarkers KW - Cancer KW - Skin tests KW - DNA damage KW - Antibodies KW - Radiation KW - Phosphorylation KW - Ionizing radiation KW - Congenital defects KW - Histone H2A KW - X 24390:Radioactive Materials KW - N 14820:DNA Metabolism & Structure KW - M2 52:C. Astrophysics (52) KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20465564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Space+Research&rft.atitle=g-H2AX+as+a+biomarker+of+DNA+damage+induced+by+ionizing+radiation+in+human+peripheral+blood+lymphocytes+and+artificial+skin&rft.au=Redon%2C+CE%3BDickey%2C+J+S%3BBonner%2C+WM%3BSedelnikova%2C+O+A&rft.aulast=Redon&rft.aufirst=CE&rft.date=2009-04-15&rft.volume=43&rft.issue=8&rft.spage=1171&rft.isbn=&rft.btitle=&rft.title=Advances+in+Space+Research&rft.issn=02731177&rft_id=info:doi/10.1016%2Fj.asr.2008.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Skin; Chromatin; Radiotherapy; Peripheral blood; Biopsy; Lymphocytes; biomarkers; Cancer; Skin tests; DNA damage; Antibodies; Phosphorylation; Ionizing radiation; Congenital defects; Histone H2A; Radiation DO - http://dx.doi.org/10.1016/j.asr.2008.10.011 ER - TY - JOUR T1 - Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. AN - 733363325; 19570025 AB - Mutations in the gene encoding LRRK2 (leucine-rich repeat kinase 2) were first identified in 2004 and have since been shown to be the single most common cause of inherited Parkinson's disease. The protein is a large GTP-regulated serine/threonine kinase that additionally contains several protein-protein interaction domains. In the present review, we discuss three important, but unresolved, questions concerning LRRK2. We first ask: what is the normal function of LRRK2? Related to this, we discuss the evidence of LRRK2 activity as a GTPase and as a kinase and the available data on protein-protein interactions. Next we raise the question of how mutations affect LRRK2 function, focusing on some slightly controversial results related to the kinase activity of the protein in a variety of in vitro systems. Finally, we discuss what the possible mechanisms are for LRRK2-mediated neurotoxicity, in the context of known activities of the protein. JF - ASN neuro AU - Greggio, Elisa AU - Cookson, Mark R AD - Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20982-3707, USA. Y1 - 2009/04/14/ PY - 2009 DA - 2009 Apr 14 VL - 1 IS - 1 KW - Intermediate Filament Proteins KW - 0 KW - desmuslin KW - LRRK2 protein, human KW - EC 2.7.11.1 KW - Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 KW - Protein-Serine-Threonine Kinases KW - Index Medicus KW - Intermediate Filament Proteins -- genetics KW - Animals KW - Humans KW - Protein Interaction Domains and Motifs -- genetics KW - Intermediate Filament Proteins -- metabolism KW - Protein-Serine-Threonine Kinases -- metabolism KW - Mutation -- genetics KW - Protein-Serine-Threonine Kinases -- genetics KW - Parkinson Disease -- enzymology KW - Parkinson Disease -- pathology KW - Parkinson Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733363325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ASN+neuro&rft.atitle=Leucine-rich+repeat+kinase+2+mutations+and+Parkinson%27s+disease%3A+three+questions.&rft.au=Greggio%2C+Elisa%3BCookson%2C+Mark+R&rft.aulast=Greggio&rft.aufirst=Elisa&rft.date=2009-04-14&rft.volume=1&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=ASN+neuro&rft.issn=1759-0914&rft_id=info:doi/10.1042%2FAN20090007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-07 N1 - Date created - 2009-07-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurochem. 2007 Oct;103(1):238-47 [17623048] Exp Cell Res. 2007 Oct 1;313(16):3658-70 [17706965] J Cell Biol. 1998 Oct 19;143(2):443-55 [9786954] Neuron. 2004 Nov 18;44(4):595-600 [15541308] Neuron. 2004 Nov 18;44(4):601-7 [15541309] Lancet. 2005 Jan 29-Feb 4;365(9457):415-6 [15680457] Neurosci Lett. 2005 Jul 15;382(3):309-11 [15925109] Ann Neurol. 2005 Jun;57(6):918-21 [15880653] Annu Rev Biochem. 2005;74:29-52 [15952880] Mov Disord. 2005 Aug;20(8):1077-8 [16001413] Neurology. 2005 Sep 13;65(5):696-700 [16157901] Neurology. 2005 Sep 13;65(5):741-4 [16157909] Neurosci Lett. 2006 Jul 10;402(1-2):92-6 [16632201] Neurobiol Dis. 2006 Aug;23(2):329-41 [16750377] Neurology. 2006 Aug 22;67(4):697-9 [16728648] Mov Disord. 2006 Aug;21(8):1232-5 [16622859] Am J Hum Genet. 2006 Oct;79(4):752-8 [16960813] Arch Neurol. 2006 Sep;63(9):1242-6 [16966501] Nat Neurosci. 2006 Oct;9(10):1231-3 [16980962] Neurology. 2006 Oct 24;67(8):1518-9 [17060595] Ann Neurol. 2006 Oct;60(4):389-98 [17068789] Mov Disord. 2006 Dec;21(12):2257-60 [17078063] Hum Mol Genet. 2007 Jan 15;16(2):223-32 [17200152] Mov Disord. 2007 Jan;22(1):55-61 [17115391] Biochemistry. 2007 Feb 6;46(5):1380-8 [17260967] Parkinsonism Relat Disord. 2007 Mar;13(2):89-92 [17222580] Nature. 2007 Mar 8;446(7132):153-8 [17344846] Curr Biol. 2007 Apr 3;17(7):592-8 [17346966] Hum Mol Genet. 2007 Mar 15;16(6):678-90 [17341485] Biochem Biophys Res Commun. 2007 Jun 8;357(3):668-71 [17442267] Parkinsonism Relat Disord. 2007 Oct;13(7):382-5 [17400507] Parkinsonism Relat Disord. 2009 Jul;15(6):466-7 [18952485] Mol Biol Evol. 2006 Dec;23(12):2423-33 [16966681] Neuron. 2006 Nov 22;52(4):587-93 [17114044] Ann Neurol. 2006 Nov;60(5):557-69 [17120249] Ann Acad Med Singapore. 2006 Nov;35(11):840-2 [17160203] Neurology. 2007 Oct 16;69(16):1595-602 [17938369] Mov Disord. 2008 Jan 30;23(2):290-4 [17999435] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1499-504 [18230735] BMC Neurosci. 2007;8:102 [18045479] BMC Neurol. 2008;8:1 [18211709] Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2693-8 [18258746] Hum Mutat. 2008 Apr;29(4):485-90 [18213618] J Neurosci. 2008 Mar 26;28(13):3384-91 [18367605] Neurology. 2008 Apr 15;70(16 Pt 2):1456-60 [18337586] J Neurochem. 2008 May;105(3):1048-56 [18182054] J Neurosci Res. 2008 Jun;86(8):1711-20 [18214993] J Biol Chem. 2008 Jun 13;283(24):16906-14 [18397888] Exp Cell Res. 2008 Jun 10;314(10):2055-65 [18445495] Lancet Neurol. 2008 Jul;7(7):583-90 [18539534] Lancet Neurol. 2008 Jul;7(7):591-4 [18539535] J Mol Evol. 2008 Jul;67(1):41-50 [18523712] EMBO J. 2008 Aug 20;27(16):2239-49 [18650931] J Neural Transm (Vienna). 2008 Sep;115(9):1275-7 [18523722] FASEB J. 2008 Sep;22(9):3103-10 [18523161] J Biomed Sci. 2008 Sep;15(5):661-7 [18523869] Neurobiol Dis. 2008 Oct;32(1):116-24 [18675914] EMBO J. 2008 Sep 17;27(18):2432-43 [18701920] Subcell Biochem. 2008;48:56-71 [18925371] J Biol Chem. 2008 Oct 31;283(44):30412-20 [18703517] BMC Med. 2008;6:32 [18986508] Biochem Biophys Res Commun. 2009 Jan 16;378(3):473-7 [19027715] FEBS J. 2009 Jan;276(2):466-78 [19076219] Biol Cell. 2009 Mar;101(3):183-91 [19152505] J Neurosci. 2009 Jan 28;29(4):1011-6 [19176810] Neurogenetics. 2009 Apr;10(2):157-9 [19020907] Parkinsonism Relat Disord. 2009 May;15(4):300-6 [18804399] Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):1022-3 [19152345] Ann Neurol. 2002 Mar;51(3):296-301 [11891824] Science. 2002 Dec 6;298(5600):1912-34 [12471243] Science. 2003 Oct 31;302(5646):841 [14593171] Biochim Biophys Acta. 2003 Dec 7;1643(1-3):5-10 [14654223] Am J Hum Genet. 2004 Jan;74(1):11-9 [14691730] Ann Neurol. 2004 Feb;55(2):164-73 [14755719] Lancet. 2004 Sep 25-Oct 1;364(9440):1167-9 [15451224] Science. 1997 Jun 27;276(5321):2045-7 [9197268] Eur Neurol. 1997;38 Suppl 1:39-43 [9276200] Nat Genet. 1998 Feb;18(2):106-8 [9462735] Ann Neurol. 2005 Nov;58(5):784-7 [16240353] J Med Genet. 2005 Nov;42(11):e65 [16272257] Curr Opin Neurol. 2005 Dec;18(6):706-11 [16280683] Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16842-7 [16269541] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18676-81 [16352719] Hum Mol Genet. 2006 Jan 15;15(2):223-32 [16321986] Ann Neurol. 2006 Feb;59(2):388-93 [16437559] Cell Signal. 2006 Jun;18(6):910-20 [16243488] Neurosci Lett. 2006 Mar 13;395(3):224-6 [16298482] J Neurol Neurosurg Psychiatry. 2006 May;77(5):665-7 [16614029] Hum Mol Genet. 2007 Jun 1;16(11):1319-26 [17409193] J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):626-8 [17210620] Biochem Biophys Res Commun. 2007 Jun 29;358(2):534-9 [17498648] J Neurochem. 2007 Jul;102(1):93-102 [17394548] Biochem J. 2007 Jul 15;405(2):307-17 [17447891] Mov Disord. 2007 Jun 15;22(8):1194-201 [17469194] Neuroscience. 2007 Jul 29;147(4):1047-58 [17611037] Hum Mol Genet. 2007 Sep 1;16(17):2031-9 [17584768] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1042/AN20090007 ER - TY - JOUR T1 - Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas. AN - 67130016; 19329485 AB - To look for a direct role of ultraviolet radiation (UV) exposure in cutaneous melanoma induction, we studied xeroderma pigmentosum (XP) patients who have defective DNA repair resulting in a 1000-fold increase in melanoma risk. These XP melanomas have the same anatomic distribution as melanomas in the general population. We analyzed laser capture microdissection samples of skin melanomas from XP patients studied at the National Institutes of Health. The tumor suppressor gene PTEN was sequenced and analyzed for UV-induced mutations. Samples from 59 melanomas (47 melanomas in situ and 12 invasive melanomas) from 8 XP patients showed mutations in the PTEN tumor suppressor gene in 56% of the melanomas. Further, 91% of the melanomas with mutations had 1 to 4 UV type base substitution mutations (occurring at adjacent pyrimidines) (P < 0.0001 compared to random mutations). We found a high frequency of amino-acid-altering mutations in the melanomas and demonstrated that these mutations impaired PTEN function; UV damage plays a direct role in induction of mutations and in inactivation of the PTEN gene in XP melanomas including in situ, the earliest stage of melanoma. This gene is known to be a key regulator of carcinogenesis and therefore these data provide solid mechanistic support for UV protection for prevention of melanoma. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Wang, Yun AU - Digiovanna, John J AU - Stern, Jere B AU - Hornyak, Thomas J AU - Raffeld, Mark AU - Khan, Sikandar G AU - Oh, Kyu-Seon AU - Hollander, M Christine AU - Dennis, Philip A AU - Kraemer, Kenneth H AD - Basic Research Laboratory, Laboratory of Pathology, Dermatology Branch, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2009/04/14/ PY - 2009 DA - 2009 Apr 14 SP - 6279 EP - 6284 VL - 106 IS - 15 KW - PTEN Phosphohydrolase KW - EC 3.1.3.67 KW - PTEN protein, human KW - Index Medicus KW - Base Sequence KW - PTEN Phosphohydrolase -- chemistry KW - Cells, Cultured KW - Humans KW - Mutation -- genetics KW - Amino Acid Sequence KW - PTEN Phosphohydrolase -- metabolism KW - PTEN Phosphohydrolase -- genetics KW - Xeroderma Pigmentosum -- pathology KW - Ultraviolet Rays KW - Melanoma -- pathology KW - Melanoma -- genetics KW - Xeroderma Pigmentosum -- genetics KW - Xeroderma Pigmentosum -- metabolism KW - Melanoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67130016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Evidence+of+ultraviolet+type+mutations+in+xeroderma+pigmentosum+melanomas.&rft.au=Wang%2C+Yun%3BDigiovanna%2C+John+J%3BStern%2C+Jere+B%3BHornyak%2C+Thomas+J%3BRaffeld%2C+Mark%3BKhan%2C+Sikandar+G%3BOh%2C+Kyu-Seon%3BHollander%2C+M+Christine%3BDennis%2C+Philip+A%3BKraemer%2C+Kenneth+H&rft.aulast=Wang&rft.aufirst=Yun&rft.date=2009-04-14&rft.volume=106&rft.issue=15&rft.spage=6279&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0812401106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-12 N1 - Date created - 2009-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2001 Sep 20;413(6853):271-2 [11565020] J Invest Dermatol. 2000 Feb;114(2):277-80 [10651986] J Photochem Photobiol B. 2001 Oct;63(1-3):19-27 [11684448] Cancer Cell. 2002 Oct;2(4):275-8 [12398891] J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Dec 25;782(1-2):105-10 [12458000] Trends Cell Biol. 2003 Sep;13(9):478-83 [12946627] J Am Acad Dermatol. 2003 Nov;49(5):865-72 [14576666] Br J Dermatol. 2004 Apr;150(4):687-92 [15099364] Oncogene. 2004 Aug 5;23(35):5968-77 [15195137] Science. 1987 Jan 16;235(4786):305-11 [3541204] Arch Dermatol. 1987 Feb;123(2):241-50 [3545087] Proc Natl Acad Sci U S A. 1987 Jul;84(14):4944-8 [3474635] Proc Natl Acad Sci U S A. 1989 Nov;86(22):8922-6 [2813430] Vet Pathol. 1991 Jan;28(1):55-65 [2017828] Proc Natl Acad Sci U S A. 1993 May 1;90(9):4216-20 [8483937] J Invest Dermatol. 1994 May;102(5):819-21 [8176269] Arch Dermatol. 1994 Aug;130(8):1018-21 [8053698] Nature. 1994 Dec 22-29;372(6508):773-6 [7997263] Oncogene. 2000 Jan 20;19(3):463-7 [10656695] Biochem J. 2000 Mar 15;346 Pt 3:827-33 [10698713] Cancer Res. 2000 Apr 1;60(7):1800-4 [10766161] Virchows Arch. 2000 May;436(5):487-93 [10881743] Hum Mutat. 2000;16(2):109-22 [10923032] J Med Genet. 2000 Sep;37(9):653-7 [10978354] Cancer Genet Cytogenet. 2001 Feb;125(1):21-6 [11297763] J Photochem Photobiol B. 2001 Oct;63(1-3):8-18 [11684447] Carcinogenesis. 1995 Jul;16(7):1557-63 [7614689] Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):11-4 [8990152] Cancer Res. 1997 Sep 1;57(17):3660-3 [9288767] Oncogene. 1998 Jul 2;16(26):3397-402 [9692547] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13513-8 [9811831] N Engl J Med. 1999 Apr 29;340(17):1341-8 [10219070] J Clin Oncol. 2005 Mar 1;23(7):1473-82 [15735123] Am J Clin Pathol. 2005 Jul;124(1):89-96 [15923161] Clin Cancer Res. 2005 Jul 15;11(14):5153-7 [16033830] Am J Clin Pathol. 2005 Oct;124(4):528-36 [16146807] N Engl J Med. 2005 Nov 17;353(20):2135-47 [16291983] J Clin Oncol. 2006 Jan 10;24(2):288-95 [16344319] J Invest Dermatol. 2006 Jan;126(1):154-60 [16417231] J Clin Oncol. 2006 Jul 1;24(19):3172-7 [16809740] Cancer Res. 2006 Jul 1;66(13):6546-52 [16818626] Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18083-8 [17114294] Cell. 2007 Jan 12;128(1):25-8 [17218252] Cell. 2007 Jan 12;128(1):157-70 [17218262] Cancer Res. 2007 Apr 1;67(7):3018-26 [17409408] Neuroscience. 2007 Apr 14;145(4):1407-17 [17184928] Hum Mutat. 2007 Jun;28(6):578-88 [17295241] Oncogene. 2007 Jul 12;26(32):4738-48 [17260012] Melanoma Res. 2008 Aug;18(4):259-67 [18626310] Cancer Res. 2001 May 15;61(10):3986-97 [11358816] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0812401106 ER - TY - JOUR T1 - Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component AN - 20241236; 10319458 AB - To prevent sexually transmitted HIV, the most desirable active ingredients of microbicides are antiretrovirals (ARVs) that directly target viral entry and avert infection at mucosal surfaces. However, most promising ARV entry inhibitors are biologicals, which are costly to manufacture and deliver to resource-poor areas where effective microbicides are urgently needed. Here, we report a manufacturing breakthrough for griffithsin (GRFT), one of the most potent HIV entry inhibitors. This red algal protein was produced in multigram quantities after extraction from Nicotiana benthamiana plants transduced with a tobacco mosaic virus vector expressing GRFT. Plant-produced GRFT (GRFT-P) was shown as active against HIV at picomolar concentrations, directly virucidal via binding to HIV envelope glycoproteins, and capable of blocking cell-to-cell HIV transmission. GRFT-P has broad-spectrum activity against HIV clades A, B, and C, with utility as a microbicide component for HIV prevention in established epidemics in sub-Saharan Africa, South Asia, China, and the industrialized West. Cognizant of the imperative that microbicides not induce epithelial damage or inflammatory responses, we also show that GRFT-P is nonirritating and noninflammatory in human cervical explants and in vivo in the rabbit vaginal irritation model. Moreover, GRFT-P is potently active in preventing infection of cervical explants by HIV-1 and has no mitogenic activity on cultured human lymphocytes. JF - Proceedings of the National Academy of Sciences, USA AU - O'Keefe, Barry R AU - Vojdani, Fakhrieh AU - Buffa, Viviana AU - Shattock, Robin J AU - Montefiori, David C AU - Bakke, James AU - Mirsalis, Jon AU - D'Andrea, Anna-Lisa AU - Hume, Steven D AU - Bratcher, Barry AU - Saucedo, Carrie J AU - McMahon, James B AU - Pogue, Gregory P AU - Palmer, Kenneth E AD - Molecular Targets Development Program, National Cancer Institute at Frederick, Frederick, MD 21702, kepalm02@gwise.louisville.edu Y1 - 2009/04/14/ PY - 2009 DA - 2009 Apr 14 SP - 6099 EP - 6104 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 15 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources; Genetics Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - AIDS KW - lectin KW - plant KW - sexually transmitted KW - tobacco mosaic virus KW - Mucosa KW - Animal models KW - Disease control KW - Man-induced effects KW - Lymphocytes KW - Hosts KW - Infection KW - Disease transmission KW - Envelopes KW - Antiviral agents KW - Human immunodeficiency virus 1 KW - Inhibitors KW - Glycoproteins KW - Algae KW - Epidemics KW - Vectors KW - Irritation KW - Tobacco mosaic virus KW - Inflammation KW - Nicotiana benthamiana KW - Viral diseases KW - Vagina KW - Africa KW - China, People's Rep. KW - Plant extracts KW - Explants KW - microbicides KW - K 03410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - G 07800:Plants and Algae KW - Q1 08587:Diseases of Cultured Organisms KW - F 06910:Microorganisms & Parasites KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20241236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Scaleable+manufacture+of+HIV-1+entry+inhibitor+griffithsin+and+validation+of+its+safety+and+efficacy+as+a+topical+microbicide+component&rft.au=O%27Keefe%2C+Barry+R%3BVojdani%2C+Fakhrieh%3BBuffa%2C+Viviana%3BShattock%2C+Robin+J%3BMontefiori%2C+David+C%3BBakke%2C+James%3BMirsalis%2C+Jon%3BD%27Andrea%2C+Anna-Lisa%3BHume%2C+Steven+D%3BBratcher%2C+Barry%3BSaucedo%2C+Carrie+J%3BMcMahon%2C+James+B%3BPogue%2C+Gregory+P%3BPalmer%2C+Kenneth+E&rft.aulast=O%27Keefe&rft.aufirst=Barry&rft.date=2009-04-14&rft.volume=106&rft.issue=15&rft.spage=6099&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0901506106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Epidemics; Viral diseases; Disease control; Man-induced effects; Inhibitors; Glycoproteins; Hosts; Lymphocytes; Disease transmission; Mucosa; Animal models; Vectors; Infection; Irritation; Inflammation; Envelopes; Antiviral agents; Vagina; Plant extracts; Explants; microbicides; Algae; Nicotiana benthamiana; Human immunodeficiency virus 1; Tobacco mosaic virus; Africa; China, People's Rep. DO - http://dx.doi.org/10.1073/pnas.0901506106 ER - TY - CPAPER T1 - Interfacial thermodynamics of confined water near molecularly rough surfaces T2 - Faraday Discussion 146: Wetting Dynamics of Hydrophobic and Structured Surfaces (FD146) AN - 754171781; 5720253 JF - Faraday Discussion 146: Wetting Dynamics of Hydrophobic and Structured Surfaces (FD146) AU - Mittal, Jeetain AU - Hummer, Gerhard Y1 - 2009/04/12/ PY - 2009 DA - 2009 Apr 12 KW - Thermodynamics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754171781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Faraday+Discussion+146%3A+Wetting+Dynamics+of+Hydrophobic+and+Structured+Surfaces+%28FD146%29&rft.atitle=Interfacial+thermodynamics+of+confined+water+near+molecularly+rough+surfaces&rft.au=Mittal%2C+Jeetain%3BHummer%2C+Gerhard&rft.aulast=Mittal&rft.aufirst=Jeetain&rft.date=2009-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Faraday+Discussion+146%3A+Wetting+Dynamics+of+Hydrophobic+and+Structured+Surfaces+%28FD146%29&rft.issn=&rft_id=info:doi/ L2 - http://www.rsc.org/images/FD146_final%20programme_web_tcm18-171487.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Meta-analysis of single-agent chemotherapy compared with combination chemotherapy as second-line treatment of advanced non-small-cell lung cancer. AN - 67122363; 19273711 AB - Doublet chemotherapy is more effective than single-agent as first-line treatment of advanced non-small-cell lung cancer (NSCLC). As second-line treatment, several randomized trials have been performed comparing single-agent with doublet chemotherapy, but each trial had an insufficient power to detect potentially relevant differences in survival. We performed meta-analysis of individual patient data from randomized trials, both published and unpublished, comparing single-agent with doublet chemotherapy as second-line treatment of advanced NSCLC. Primary end point was overall survival (OS). All statistical analyses were stratified by trial. Eight eligible trials were identified. Data of two trials were not available, and data of six trials (847 patients) were collected. Median age was 61 years. Performance status was 0 or 1 in 90%; 80% of patients had received previous platin-based chemotherapy. OS was not significantly different between arms (P = .32). Median OS was 37.3 and 34.7 weeks in the doublet and single-agent arms, respectively. Hazard ratio (HR) was 0.92 (95% CI, 0.79 to 1.08). Response rate was 15.1% with doublet and 7.3% with single-agent (P = .0004). Median progression-free survival was 14 weeks for doublet and 11.7 weeks for single agent (P = .0009; HR, 0.79; 95% CI, 0.68 to 0.91). There was no significant heterogeneity among trials for the three efficacy outcomes. Patients treated with doublet chemotherapy had significantly more grade 3 to 4 hematologic (41% v 25%; P < .0001) and grade 3 to 4 nonhematologic toxicity (28% v 22%; P = .034). Doublet chemotherapy as second-line treatment of advanced NSCLC significantly increases response rate and progression-free survival, but is more toxic and does not improve overall survival compared to single-agent. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Di Maio, Massimo AU - Chiodini, Paolo AU - Georgoulias, Vassilis AU - Hatzidaki, Dora AU - Takeda, Koji AU - Wachters, Floris M AU - Gebbia, Vittorio AU - Smit, Egbert F AU - Morabito, Alessandro AU - Gallo, Ciro AU - Perrone, Francesco AU - Gridelli, Cesare AD - Clinical Trials Unit, National Cancer Institute, Department of Medicine and Public Health, Second University of Napoli, Italy. Y1 - 2009/04/10/ PY - 2009 DA - 2009 Apr 10 SP - 1836 EP - 1843 VL - 27 IS - 11 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Young Adult KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Male KW - Female KW - Survival Analysis KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Antineoplastic Agents -- administration & dosage KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- mortality KW - Carcinoma, Non-Small-Cell Lung -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67122363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Meta-analysis+of+single-agent+chemotherapy+compared+with+combination+chemotherapy+as+second-line+treatment+of+advanced+non-small-cell+lung+cancer.&rft.au=Di+Maio%2C+Massimo%3BChiodini%2C+Paolo%3BGeorgoulias%2C+Vassilis%3BHatzidaki%2C+Dora%3BTakeda%2C+Koji%3BWachters%2C+Floris+M%3BGebbia%2C+Vittorio%3BSmit%2C+Egbert+F%3BMorabito%2C+Alessandro%3BGallo%2C+Ciro%3BPerrone%2C+Francesco%3BGridelli%2C+Cesare&rft.aulast=Di+Maio&rft.aufirst=Massimo&rft.date=2009-04-10&rft.volume=27&rft.issue=11&rft.spage=1836&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2008.17.5844 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2009-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2008.17.5844 ER - TY - JOUR T1 - Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. AN - 67116940; 19357635 AB - This report updates and combines earlier versions of guidelines for the prevention and treatment of opportunistic infections (OIs) in HIV-infected adults (i.e., persons aged >/=18 years) and adolescents (i.e., persons aged 13--17 years), last published in 2002 and 2004, respectively. It has been prepared by the Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the HIV Medicine Association (HIVMA) of the Infectious Diseases Society of America (IDSA). The guidelines are intended for use by clinicians and other health-care providers, HIV-infected patients, and policy makers in the United States. These guidelines address several OIs that occur in the United States and five OIs that might be acquired during international travel. Topic areas covered for each OI include epidemiology, clinical manifestations, diagnosis, prevention of exposure; prevention of disease by chemoprophylaxis and vaccination; discontinuation of primary prophylaxis after immune reconstitution; treatment of disease; monitoring for adverse effects during treatment; management of treatment failure; prevention of disease recurrence; discontinuation of secondary prophylaxis after immune reconstitution; and special considerations during pregnancy. These guidelines were developed by a panel of specialists from the United States government and academic institutions. For each OI, a small group of specialists with content-matter expertise reviewed the literature for new information since the guidelines were last published; they then proposed revised recommendations at a meeting held at NIH in June 2007. After these presentations and discussion, the revised guidelines were further reviewed by the co-editors; by the Office of AIDS Research, NIH; by specialists at CDC; and by HIVMA of IDSA before final approval and publication. The recommendations are rated by a letter that indicates the strength of the recommendation and a Roman numeral that indicates the quality of evidence supporting the recommendation, so that readers can ascertain how best to apply the recommendations in their practice environments. Major changes in the guidelines include 1) greater emphasis on the importance of antiretroviral therapy for the prevention and treatment of OIs, especially those OIs for which no specific therapy exists; 2) information regarding the diagnosis and management of immune reconstitution inflammatory syndromes; 3) information regarding the use of interferon-gamma release assays for the diagnosis of latent Mycobacterium tuberculosis (TB) infection; 4) updated information concerning drug interactions that affect the use of rifamycin drugs for prevention and treatment of TB; 5) the addition of a section on hepatitis B virus infection; and 6) the addition of malaria to the list of OIs that might be acquired during international travel. This report includes eleven tables pertinent to the prevention and treatment of OIs, a figure that pertains to the diagnois of tuberculosis, a figure that describes immunization recommendations, and an appendix that summarizes recommendations for prevention of exposure to opportunistic pathogens. JF - MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports AU - Kaplan, Jonathan E AU - Benson, Constance AU - Holmes, King K AU - Brooks, John T AU - Pau, Alice AU - Masur, Henry AU - Centers for Disease Control and Prevention (CDC) AU - National Institutes of Health AU - HIV Medicine Association of the Infectious Diseases Society of America AD - CDC, Atlanta, Georgia, USA. ; Centers for Disease Control and Prevention (CDC) ; National Institutes of Health ; HIV Medicine Association of the Infectious Diseases Society of America Y1 - 2009/04/10/ PY - 2009 DA - 2009 Apr 10 SP - 1 EP - 207; quiz CE1-4 VL - 58 KW - Anti-HIV Agents KW - 0 KW - Anti-Retroviral Agents KW - Index Medicus KW - Acute Disease KW - Young Adult KW - Pregnancy Complications, Infectious -- prevention & control KW - Treatment Failure KW - Drug Interactions KW - Humans KW - Immune Reconstitution Inflammatory Syndrome -- chemically induced KW - Pregnancy Complications, Infectious -- drug therapy KW - Recurrence KW - Pregnancy KW - Adult KW - Immune Reconstitution Inflammatory Syndrome -- diagnosis KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - AIDS-Related Opportunistic Infections -- drug therapy KW - Anti-HIV Agents -- therapeutic use KW - Anti-Retroviral Agents -- adverse effects KW - Anti-HIV Agents -- adverse effects KW - AIDS-Related Opportunistic Infections -- prevention & control KW - AIDS-Related Opportunistic Infections -- diagnosis KW - AIDS-Related Opportunistic Infections -- epidemiology KW - Anti-Retroviral Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67116940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Recommendations+and+reports+%3A+Morbidity+and+mortality+weekly+report.+Recommendations+and+reports&rft.atitle=Guidelines+for+prevention+and+treatment+of+opportunistic+infections+in+HIV-infected+adults+and+adolescents%3A+recommendations+from+CDC%2C+the+National+Institutes+of+Health%2C+and+the+HIV+Medicine+Association+of+the+Infectious+Diseases+Society+of+America.&rft.au=Kaplan%2C+Jonathan+E%3BBenson%2C+Constance%3BHolmes%2C+King+K%3BBrooks%2C+John+T%3BPau%2C+Alice%3BMasur%2C+Henry%3BCenters+for+Disease+Control+and+Prevention+%28CDC%29%3BNational+Institutes+of+Health%3BHIV+Medicine+Association+of+the+Infectious+Diseases+Society+of+America&rft.aulast=Kaplan&rft.aufirst=Jonathan&rft.date=2009-04-10&rft.volume=58&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=MMWR.+Recommendations+and+reports+%3A+Morbidity+and+mortality+weekly+report.+Recommendations+and+reports&rft.issn=1545-8601&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-14 N1 - Date created - 2009-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proteolytic Cleavage of a C-terminal Prosequence, Leading to Autoprocessing at the N Terminus, Activates Leucine Aminopeptidase from Pseudomonas aeruginosa AN - 21083597; 11080612 AB - At high bacterial cell density the gene expression program of Pseudomonas aeruginosa is regulated by quorum sensing. Among the gene products highly up-regulated by this system is an exoprotease, leucine aminopeptidase (PA-LAP), which is coexpressed with several known virulence factors and secreted as a proenzyme. We undertook a study of its activation by expressing the full-length proform of PA-LAP recombinantly in Escherichia coli (here termed, rLAP55) and characterizing individual steps in its conversion to an active enzyme. Activation is initiated with the proteolytic removal of a C-terminal prosequence. Removal of 620 amino acids is accomplished by Pseudomonas elastase, which is also positively regulated by quorum sensing. Activation is also mediated by other proteases that cleave rLAP55 near its C terminus. The importance of the C terminus was confirmed by showing that C-terminal deletions of 1-24 amino acids produce a fully active enzyme. The removal of C-terminal prosequences either by proteolysis or deletion leads to an unusual autoprocessing event at the N terminus. Autoprocessing is apparently an intramolecular event, requires the active site of LAP, and results in the removal of 12 N-terminal amino acids. Furthermore, a detailed analysis of the C-terminal prosequence suggests that the proenzyme state is dependent on the presence of a basic side chain contributed by the last amino acid, lysine 536. Our data support a model whereby full-length PA-LAP is activated in a two-step process; proteolytic cleavage at the C terminus is followed by an intramolecular autocatalytic removal of a 12-amino acid propeptide at the N terminus. JF - Journal of Biological Chemistry AU - Sarnovsky, Robert AU - Rea, Jennifer AU - Makowski, Matt AU - Hertle, Ralf AU - Kelly, Colleen AU - Antignani, Antonella AU - Pastrana, Diana V AU - FitzGerald, David J AD - Laboratory of Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2009/04/10/ PY - 2009 DA - 2009 Apr 10 SP - 10243 EP - 10253 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 284 IS - 15 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Proteolysis KW - Data processing KW - Amino acids KW - virulence factors KW - quorum sensing KW - Elastase KW - Cell density KW - Lysine KW - Enzymes KW - Proenzymes KW - Gene expression KW - Aminopeptidase KW - Escherichia coli KW - Leucine KW - Proteinase KW - Pseudomonas aeruginosa KW - J 02310:Genetics & Taxonomy KW - A 01310:Products of Microorganisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21083597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Proteolytic+Cleavage+of+a+C-terminal+Prosequence%2C+Leading+to+Autoprocessing+at+the+N+Terminus%2C+Activates+Leucine+Aminopeptidase+from+Pseudomonas+aeruginosa&rft.au=Sarnovsky%2C+Robert%3BRea%2C+Jennifer%3BMakowski%2C+Matt%3BHertle%2C+Ralf%3BKelly%2C+Colleen%3BAntignani%2C+Antonella%3BPastrana%2C+Diana+V%3BFitzGerald%2C+David+J&rft.aulast=Sarnovsky&rft.aufirst=Robert&rft.date=2009-04-10&rft.volume=284&rft.issue=15&rft.spage=10243&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M808686200 L2 - http://www.jbc.org/cgi/reprint/284/15/10243.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Proteolysis; Amino acids; Data processing; virulence factors; quorum sensing; Cell density; Elastase; Enzymes; Lysine; Proenzymes; Gene expression; Aminopeptidase; Leucine; Proteinase; Escherichia coli; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1074/jbc.M808686200 ER - TY - JOUR T1 - Glioma Stem Cells: Not All Created Equal AN - 20473898; 9177134 AB - A growing body of evidence suggests that only a small subpopulation of malignant glioma cells have true tumorigenic potential. A study by Penuelas et al. in this issue of Cancer Cell demonstrates that TGF- beta can stimulate self-renewal and inhibit differentiation in a proportion of these glioma-initiating cells. JF - Cancer Cell AU - Fine, HA AD - Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, hfine@mail.nih.gov Y1 - 2009/04/07/ PY - 2009 DA - 2009 Apr 07 SP - 247 EP - 249 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 15 IS - 4 SN - 1535-6108, 1535-6108 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Differentiation KW - Stem cells KW - Glioma cells KW - Transforming growth factor- beta KW - W 30965:Miscellaneous, Reviews KW - N3 11150:General and miscellaneous topics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20473898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Cell&rft.atitle=Glioma+Stem+Cells%3A+Not+All+Created+Equal&rft.au=Fine%2C+HA&rft.aulast=Fine&rft.aufirst=HA&rft.date=2009-04-07&rft.volume=15&rft.issue=4&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Cancer+Cell&rft.issn=15356108&rft_id=info:doi/10.1016%2Fj.ccr.2009.03.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Transforming growth factor- beta; Glioma cells DO - http://dx.doi.org/10.1016/j.ccr.2009.03.010 ER - TY - JOUR T1 - Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus AN - 20222155; 10319423 AB - Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has recently emerged worldwide. The United States, in particular, is experiencing a serious epidemic of CA-MRSA that is almost entirely caused by an extraordinarily infectious strain named USA300. However, the molecular determinants underlying the pathogenic success of CA-MRSA are mostly unknown. To gain insight into the evolution of the exceptional potential of USA300 to cause disease, we compared the phylogeny and virulence of USA300 with that of closely related MRSA clones. We discovered that the sublineage from which USA300 evolved is characterized by a phenotype of high virulence that is clearly distinct from other MRSA strains. Namely, USA300 and its progenitor, USA500, had high virulence in animal infection models and the capacity to evade innate host defense mechanisms. Furthermore, our results indicate that increased virulence in the USA300/USA500 sublineage is attributable to differential expression of core genome-encoded virulence determinants, such as phenol- soluble modulins and a-toxin. Notably, the fact that the virulence phenotype of USA300 was already established in its progenitor indicates that acquisition of mobile genetic elements has played a limited role in the evolution of USA300 virulence and points to a possibly different role of those elements. Thus, our results highlight the importance of differential gene expression in the evolution of USA300 virulence. This finding calls for a profound revision of our notion about CA-MRSA pathogenesis at the molecular level and has important implications for design of therapeutics directed against CA-MRSA. JF - Proceedings of the National Academy of Sciences, USA AU - Li, Min AU - Diep, Binh An AU - Villaruz, Amer E AU - Braughton, Kevin R AU - Jiang, Xiaofei AU - DeLeo, Frank R AU - Chambers, Henry F AU - Lu, Yuan AU - Otto, Michael AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, and 9000 Rockville Pike, Bethesda, MD 20892, motto@niaid.nih.gov Y1 - 2009/04/07/ PY - 2009 DA - 2009 Apr 07 SP - 5883 EP - 5888 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 14 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Epidemics KW - Drug resistance KW - Animal models KW - a-Toxin KW - Infection KW - Virulence KW - Gene expression KW - Stem cells KW - Defense mechanisms KW - Staphylococcus aureus KW - Evolution KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20222155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Evolution+of+virulence+in+epidemic+community-associated+methicillin-resistant+Staphylococcus+aureus&rft.au=Li%2C+Min%3BDiep%2C+Binh+An%3BVillaruz%2C+Amer+E%3BBraughton%2C+Kevin+R%3BJiang%2C+Xiaofei%3BDeLeo%2C+Frank+R%3BChambers%2C+Henry+F%3BLu%2C+Yuan%3BOtto%2C+Michael&rft.aulast=Li&rft.aufirst=Min&rft.date=2009-04-07&rft.volume=106&rft.issue=14&rft.spage=5883&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0900743106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phylogeny; Gene expression; Virulence; Stem cells; Epidemics; Drug resistance; Animal models; a-Toxin; Defense mechanisms; Infection; Evolution; Staphylococcus aureus DO - http://dx.doi.org/10.1073/pnas.0900743106 ER - TY - JOUR T1 - Simultaneous quantification of nicotine, opioids, cocaine, and metabolites in human fetal postmortem brain by liquid chromatography tandem mass spectrometry AN - 753695377; 13323742 AB - A validated method for simultaneous LCMSMS quantification of nicotine, cocaine, 6-acetylmorphine (6AM), codeine, and metabolites in 100 mg fetal human brain was developed and validated. After homogenization and solid-phase extraction, analytes were resolved on a Hydro-RP analytical column with gradient elution. Empirically determined linearity was from 5--5,000 pg/mg for cocaine and benzoylecgonine (BE), 25--5,000 pg/mg for cotinine, ecgonine methyl ester (EME) and 6AM, 50-5000 pg/mg for trans-3-hydroxycotinine (OH-cotinine) and codeine, and 250--5,000 pg/mg for nicotine. Potential endogenous and exogenous interferences were resolved. Intra- and inter-assay analytical recoveries were >=92%, intra- and inter-day and total assay imprecision were =67.2% with <=83% matrix effect. Method applicability was demonstrated with a postmortem fetal brain containing 40 pg/mg cotinine, 65 pg/mg OH-cotinine, 13 pg/mg cocaine, 34 pg/mg EME, and 525 pg/mg BE. This validated method is useful for determination of nicotine, opioid, and cocaine biomarkers in brain. JF - Analytical and Bioanalytical Chemistry AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, Biomedical Research Center, 251 Bayview Boulevard Suite 5A721, Baltimore, MD 21224, USA, mhuestis@intra.nida.nih.gov PY - 2009 SP - 1957 EP - 1965 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 393 IS - 8 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts; CSA Neurosciences Abstracts KW - Bioindicators KW - Mass Spectrometry KW - Brain KW - Metabolites KW - Esters KW - biomarkers KW - Fetuses KW - Codeine KW - Mass spectroscopy KW - Cotinine KW - Nicotine KW - Liquid chromatography KW - Assay KW - Liquid Chromatography KW - Opioids KW - Cocaine KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753695377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Simultaneous+quantification+of+nicotine%2C+opioids%2C+cocaine%2C+and+metabolites+in+human+fetal+postmortem+brain+by+liquid+chromatography+tandem+mass+spectrometry&rft.au=Shakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Shakleya&rft.aufirst=Diaa&rft.date=2009-04-01&rft.volume=393&rft.issue=8&rft.spage=1957&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-009-2661-8 L2 - http://www.springerlink.com/content/71kt06004271xkp5/?p=c8fd02fca76f4ea6a83686c41291352f&pi=19 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Cotinine; Liquid chromatography; Nicotine; Brain; Metabolites; Opioids; Cocaine; biomarkers; Mass spectroscopy; Codeine; Fetuses; Bioindicators; Mass Spectrometry; Assay; Liquid Chromatography; Esters DO - http://dx.doi.org/10.1007/s00216-009-2661-8 ER - TY - JOUR T1 - Dysregulated molecular networks in head and neck carcinogenesis. AN - 733100150; 18805044 AB - Multiple genetic and epigenetic events, including the aberrant expression and function of molecules regulating cell signaling, growth, survival, motility, angiogenesis, and cell cycle control, underlie the progressive acquisition of a malignant phenotype in squamous carcinomas of the head and neck (HNSCC). In this regard, there has been a recent explosion in our understanding on how extracellular components, cell surface molecules, and a myriad of intracellular proteins and second messenger systems interact with each other, and are organized in pathways and networks to control cellular and tissue functions and cell fate decisions. This emerging ability to understand the basic mechanism controlling inter- and intra-cellular communication has provided an unprecedented opportunity to understand how their dysregulation contributes to the growth and dissemination of human cancers. Here, we will discuss the emerging information on how the use of modern technologies, including gene array and proteomic studies, combined with the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFkappaB, Stat, Wnt/beta-catenin, TGF-beta, and PI3K-AKT-mTOR signaling pathways, can help elucidate the molecular mechanisms underlying HNSCC progression. Ultimately, we can envision that this knowledge may provide tremendous opportunities for the diagnosis of premalignant squamous lesions, and for the development of novel molecular-targeted strategies for the prevention and treatment of HNSCC. JF - Oral oncology AU - Molinolo, Alfredo A AU - Amornphimoltham, Panomwat AU - Squarize, Cristiane H AU - Castilho, Rogerio M AU - Patel, Vyomesh AU - Gutkind, J Silvio AD - Oral and Pharyngeal Cancer Branch, National Institute of Craniofacial and Dental Research, National Institutes of Health, Building 30, Room 211, 30 Convent Drive, Bethesda, MD 20892-4330, USA. PY - 2009 SP - 324 EP - 334 VL - 45 IS - 4-5 KW - NF-kappa B KW - 0 KW - Transforming Growth Factor beta KW - Wnt Proteins KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Wnt Proteins -- metabolism KW - Receptor, Epidermal Growth Factor -- metabolism KW - Oncogenes KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Genes, Tumor Suppressor KW - Humans KW - Transforming Growth Factor beta -- metabolism KW - NF-kappa B -- metabolism KW - Precancerous Conditions -- genetics KW - Signal Transduction -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Head and Neck Neoplasms -- genetics KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733100150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+oncology&rft.atitle=Dysregulated+molecular+networks+in+head+and+neck+carcinogenesis.&rft.au=Molinolo%2C+Alfredo+A%3BAmornphimoltham%2C+Panomwat%3BSquarize%2C+Cristiane+H%3BCastilho%2C+Rogerio+M%3BPatel%2C+Vyomesh%3BGutkind%2C+J+Silvio&rft.aulast=Molinolo&rft.aufirst=Alfredo&rft.date=2009-04-01&rft.volume=45&rft.issue=4-5&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Oral+oncology&rft.issn=1879-0593&rft_id=info:doi/10.1016%2Fj.oraloncology.2008.07.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-14 N1 - Date created - 2009-05-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Immunol. 2006 Aug;6(8):602-12 [16868551] Cancer Lett. 2006 Aug 28;240(2):306-11 [16303247] Oral Dis. 2006 Sep;12(5):443-54 [16910914] Int J Cancer. 2006 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15;67(20):9643-8 [17942893] Annu Rev Cell Dev Biol. 2007;23:675-99 [17645413] Oncogene. 2000 Jun 29;19(28):3220-4 [10918578] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.oraloncology.2008.07.011 ER - TY - JOUR T1 - Clostridium difficile infection: current perspectives. AN - 67459935; 19578325 AB - Clostridium difficile infection (CDI), long-associated with morbidity and mortality in healthcare settings, has evolved in recent years with unprecedented clinical manifestations. Today, CDI is characterized by unusually toxigenic and resistant subtypes, expanded epidemiology, and a growing list of risk factors. In this article, we discuss current trends and research for CDI in critical care settings, and new controversies that influence clinical practice. CDI is the focus of intense and comprehensive research. For the critical care practitioner, relevant knowledge includes diagnosis of CDI, defining the severity of disease, the role of proton pump inhibitors, and treatment options for refractory or relapsing disease. Annually, CDI adds billions of dollars to US healthcare costs compared with just a few years ago, and reflects a new and profound pattern of morbidity and mortality. As this disease changes, our knowledge and practice patterns must adjust to meet the current challenge of CDI. JF - Current opinion in critical care AU - Janka, Jacqueline AU - O'Grady, Naomi P AD - Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 149 EP - 153 VL - 15 IS - 2 KW - Anti-Bacterial Agents KW - 0 KW - Proton Pump Inhibitors KW - Virulence Factors KW - Vancomycin KW - 6Q205EH1VU KW - Index Medicus KW - Severity of Illness Index KW - Anti-Bacterial Agents -- therapeutic use KW - Humans KW - Intensive Care Units KW - Proton Pump Inhibitors -- therapeutic use KW - United States -- epidemiology KW - Vancomycin -- therapeutic use KW - Secondary Prevention KW - Clostridium Infections -- transmission KW - Clostridium Infections -- drug therapy KW - Clostridium Infections -- epidemiology KW - Clostridium difficile -- pathogenicity KW - Clostridium Infections -- diagnosis KW - Clostridium Infections -- physiopathology KW - Clostridium difficile -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67459935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+critical+care&rft.atitle=Clostridium+difficile+infection%3A+current+perspectives.&rft.au=Janka%2C+Jacqueline%3BO%27Grady%2C+Naomi+P&rft.aulast=Janka&rft.aufirst=Jacqueline&rft.date=2009-04-01&rft.volume=15&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+critical+care&rft.issn=1531-7072&rft_id=info:doi/10.1097%2FMCC.0b013e328324e6ad LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-27 N1 - Date created - 2009-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MCC.0b013e328324e6ad ER - TY - JOUR T1 - Ethical issues in treating pregnant women with severe mental illness. AN - 67362131; 19517649 AB - Severe mental illness tends to occur and recur among women in the reproductive period. Both the disorders and the treatments may have effects on the mother and the foetus. The clinician hence is often in a dilemma when treating pregnant women with severe mental illness and is challenged with ethical issues related to decision making in this regard. Both treatment and non treatment are not without risks and this is particularly challenging if the mother has active symptoms and cannot make decisions because of impaired capacity. This paper highlights some of these ethical and clinical dilemmas through case vignettes based on data from a specialised perinatal psychiatry service. JF - Indian journal of medical ethics AU - Desai, Geetha AU - Chandra, Prabha S AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560 029, India. desaigeetha@gmail.com PY - 2009 SP - 75 EP - 77 VL - 6 IS - 2 SN - 0974-8466, 0974-8466 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Decision Making -- ethics KW - Abortion, Induced -- ethics KW - Humans KW - Mental Competency KW - Antipsychotic Agents -- adverse effects KW - Female KW - Professional-Patient Relations -- ethics KW - Pregnancy KW - India KW - Mental Disorders -- therapy KW - Pregnancy Complications -- psychology KW - Pregnancy Complications -- therapy KW - Mental Disorders -- drug therapy KW - Prenatal Care -- ethics KW - Pregnancy Complications -- drug therapy KW - Mental Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67362131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+journal+of+medical+ethics&rft.atitle=Ethical+issues+in+treating+pregnant+women+with+severe+mental+illness.&rft.au=Desai%2C+Geetha%3BChandra%2C+Prabha+S&rft.aulast=Desai&rft.aufirst=Geetha&rft.date=2009-04-01&rft.volume=6&rft.issue=2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Indian+journal+of+medical+ethics&rft.issn=09748466&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-24 N1 - Date created - 2009-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Indian J Med Ethics. 2009 Jul-Sep;6(3):172 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Renal toxicity of targeted therapies. AN - 67312626; 19421832 AB - The use of molecular targeted therapies for the treatment of cancer has increased over the last decade. The benefits of these compounds in terms of efficacy are often relatively modest and counter balanced by the occurrence of significant toxicities. Many of these newer agents used in clinical practice lack specificity and selectivity and have a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity are poorly defined and numerous class-specific toxicities have been described. The kidney is an organ where most of these targeted pathways are expressed. Preclinical data and human renal biopsies have generated an understanding of the mechanisms involved in how targeted agents can cause renal toxicity. This review article discusses the observed nephrotoxicity with this burgeoning class of therapeutics and reviews both the biological reasons for its occurrence and possible ways to prevent significant renal damage. JF - Targeted oncology AU - Kelly, Ronan J AU - Billemont, Bertrand AU - Rixe, Olivier AD - National Cancer Institute, Medical Oncology Branch, Center for Cancer Research, NIH, Bethesda, MD 20892, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 121 EP - 133 VL - 4 IS - 2 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Benzenesulfonates KW - Indoles KW - Phenylurea Compounds KW - Protein Kinase Inhibitors KW - Pyridines KW - Pyrroles KW - Vascular Endothelial Growth Factor A KW - Niacinamide KW - 25X51I8RD4 KW - Bevacizumab KW - 2S9ZZM9Q9V KW - sorafenib KW - 9ZOQ3TZI87 KW - sunitinib KW - V99T50803M KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Niacinamide -- analogs & derivatives KW - Antibodies, Monoclonal -- therapeutic use KW - Vascular Endothelial Growth Factor A -- antagonists & inhibitors KW - Hypertension -- chemically induced KW - Neovascularization, Pathologic -- drug therapy KW - Hypertension -- prevention & control KW - Proteinuria -- prevention & control KW - Antibodies, Monoclonal -- adverse effects KW - Vascular Endothelial Growth Factor A -- immunology KW - Drug Evaluation, Preclinical KW - Proteinuria -- chemically induced KW - Pyrroles -- adverse effects KW - Neoplasms -- drug therapy KW - Benzenesulfonates -- therapeutic use KW - Kidney -- pathology KW - Benzenesulfonates -- adverse effects KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- adverse effects KW - Indoles -- adverse effects KW - Kidney -- drug effects KW - Indoles -- therapeutic use KW - Pyridines -- therapeutic use KW - Pyrroles -- therapeutic use KW - Pyridines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67312626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Targeted+oncology&rft.atitle=Renal+toxicity+of+targeted+therapies.&rft.au=Kelly%2C+Ronan+J%3BBillemont%2C+Bertrand%3BRixe%2C+Olivier&rft.aulast=Kelly&rft.aufirst=Ronan&rft.date=2009-04-01&rft.volume=4&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Targeted+oncology&rft.issn=1776-260X&rft_id=info:doi/10.1007%2Fs11523-009-0109-x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-20 N1 - Date created - 2009-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11523-009-0109-x ER - TY - JOUR T1 - The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats. AN - 67288999; 19459743 AB - The major component, called curcumin, of turmeric (Curcuma longa L.) (Family Zingiberaceae) powder is responsible for its biological actions. The present study aimed to prove the protective effect of turmeric extract against doxorubicin (DOX)-induced cardiac, hepatic, and renal toxicity as evaluated in rats. Body weight and urine volume of the animal groups under investigation were recorded daily throughout the experimental period. Also, the cardiac, hepatic, and renal toxicities were determined by estimating the changes in serum activities of the enzymes lactate dehydrogenase (LDH) and creatine kinase (CK), serum levels of alanine aminotransferase, aspartate aminotransferase, nitric oxide, albumin, and calcium, and kidney and liver tissue activities of superoxide dismutase and glutathione peroxidase, as well as the contents of glutathione and malondialdehyde. Hyperlipidemia was also determined, and protein and albumin changes in urine were estimated. Biochemical and histopathological findings demonstrate that turmeric extract has multiple therapeutic activities that are beneficially protective, and it has an ameliorative effect against DOX-induced cardiac toxicity and hepatotoxicity and blocks DOX-induced nephrosis. Similarly, turmeric extract inhibited the DOX-induced increase in plasma cholesterol, LDH, and CK. The present findings conclude that the turmeric extract has multiple therapeutic activities that block the cardiac, hepatic, and renal toxicities induced by DOX, and it also possibly acts as a free radical scavenger. JF - Journal of medicinal food AU - Mohamad, Ragaa Hosny AU - El-Bastawesy, Amal Mohamad AU - Zekry, Zekry Khalid AU - Al-Mehdar, Hussain A AU - Al-Said, Mohamad Gamil Abdel Monaam AU - Aly, Soaad Shaker AU - Sharawy, Sabry Mohamed AU - El-Merzabani, Mahmuod M AD - Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. ragaatahtawy@gmail.com Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 394 EP - 402 VL - 12 IS - 2 KW - Antibiotics, Antineoplastic KW - 0 KW - Antioxidants KW - Lipids KW - Plant Extracts KW - Serum Albumin KW - Troponin T KW - Nitric Oxide KW - 31C4KY9ESH KW - Malondialdehyde KW - 4Y8F71G49Q KW - Doxorubicin KW - 80168379AG KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Transaminases KW - EC 2.6.1.- KW - Creatine Kinase KW - EC 2.7.3.2 KW - Glutathione KW - GAN16C9B8O KW - Curcumin KW - IT942ZTH98 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Lipids -- blood KW - Serum Albumin -- metabolism KW - Animals KW - Heart Diseases -- drug therapy KW - Troponin T -- blood KW - Random Allocation KW - Calcium -- blood KW - Nitric Oxide -- metabolism KW - Chemical and Drug Induced Liver Injury -- drug therapy KW - Rats KW - Malondialdehyde -- metabolism KW - Transaminases -- blood KW - Antioxidants -- metabolism KW - Creatine Kinase -- blood KW - L-Lactate Dehydrogenase -- blood KW - Kidney Diseases -- drug therapy KW - Male KW - Plant Extracts -- pharmacology KW - Phytotherapy KW - Curcumin -- therapeutic use KW - Curcuma -- chemistry KW - Plant Extracts -- therapeutic use KW - Drug-Related Side Effects and Adverse Reactions -- drug therapy KW - Doxorubicin -- toxicity KW - Antibiotics, Antineoplastic -- toxicity KW - Curcumin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67288999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+food&rft.atitle=The+role+of+Curcuma+longa+against+doxorubicin+%28adriamycin%29-induced+toxicity+in+rats.&rft.au=Mohamad%2C+Ragaa+Hosny%3BEl-Bastawesy%2C+Amal+Mohamad%3BZekry%2C+Zekry+Khalid%3BAl-Mehdar%2C+Hussain+A%3BAl-Said%2C+Mohamad+Gamil+Abdel+Monaam%3BAly%2C+Soaad+Shaker%3BSharawy%2C+Sabry+Mohamed%3BEl-Merzabani%2C+Mahmuod+M&rft.aulast=Mohamad&rft.aufirst=Ragaa&rft.date=2009-04-01&rft.volume=12&rft.issue=2&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+food&rft.issn=1557-7600&rft_id=info:doi/10.1089%2Fjmf.2007.0715 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-10 N1 - Date created - 2009-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/jmf.2007.0715 ER - TY - JOUR T1 - Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions. AN - 67169325; 19349511 AB - Vandetanib is a novel, orally available inhibitor of different intracellular signaling pathways involved in tumor growth, progression, and angiogenesis: vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and REarranged during Transfection tyrosine kinase activity. Phase I clinical trials have shown that vandetanib is well tolerated as a single agent at daily doses < or =300 mg. In the phase II setting, negative results were observed with vandetanib in small cell lung cancer, metastatic breast cancer, and multiple myeloma. In contrast, three randomized phase II studies showed that vandetanib prolonged the progression-free survival (PFS) time of patients with non-small cell lung cancer (NSCLC) as a single agent when compared with gefitinib or when added to chemotherapy. Rash, diarrhea, hypertension, fatigue, and asymptomatic QTc prolongation were the most common adverse events. Antitumor activity was also observed in medullary thyroid cancer. Four randomized phase III clinical trials in NSCLC are exploring the efficacy of vandetanib in combination with docetaxel, the Zactima in cOmbination with Docetaxel In non-small cell lung Cancer (ZODIAC) trial, or with pemetrexed, the Zactima Efficacy with Alimta in Lung cancer (ZEAL) trial, or as a single agent, the Zactima Efficacy when Studied versus Tarceva (ZEST) and the Zactima Efficacy trial for NSCLC Patients with History of EGFR-TKI chemo-Resistance (ZEPHYR) trials. Based on a press release by the sponsor of these trials, the PFS time was longer with vandetanib in the ZODIAC and ZEAL trials; the ZEST trial was negative for its primary superiority analysis, but was successful according to a preplanned noninferiority analysis of PFS. Ongoing phase II and III clinical trials will better define the appropriate schedule, the optimal setting of evaluation, and the safety of long-term use of vandetanib. JF - The oncologist AU - Morabito, Alessandro AU - Piccirillo, Maria Carmela AU - Falasconi, Fabiano AU - De Feo, Gianfranco AU - Del Giudice, Antonia AU - Bryce, Jane AU - Di Maio, Massimo AU - De Maio, Ermelinda AU - Normanno, Nicola AU - Perrone, Francesco AD - Clinical Trials Unit, National Cancer Institute, Napoli, Italy. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 378 EP - 390 VL - 14 IS - 4 KW - Glutamates KW - 0 KW - Piperidines KW - Quinazolines KW - Taxoids KW - Pemetrexed KW - 04Q9AIZ7NO KW - docetaxel KW - 15H5577CQD KW - Guanine KW - 5Z93L87A1R KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Receptors, Vascular Endothelial Growth Factor KW - Vascular Endothelial Growth Factor Receptor-1 KW - N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine KW - YO460OQ37K KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Glutamates -- administration & dosage KW - Clinical Trials, Phase II as Topic KW - Clinical Trials, Phase III as Topic KW - Humans KW - Clinical Trials, Phase I as Topic KW - Treatment Outcome KW - Guanine -- analogs & derivatives KW - Drug Therapy -- methods KW - Vascular Endothelial Growth Factor Receptor-1 -- drug effects KW - Guanine -- administration & dosage KW - Taxoids -- administration & dosage KW - Receptor, Epidermal Growth Factor -- drug effects KW - Quinazolines -- administration & dosage KW - Receptors, Vascular Endothelial Growth Factor -- drug effects KW - Small Cell Lung Carcinoma -- drug therapy KW - Lung Neoplasms -- drug therapy KW - Piperidines -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67169325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Vandetanib+%28ZD6474%29%2C+a+dual+inhibitor+of+vascular+endothelial+growth+factor+receptor+%28VEGFR%29+and+epidermal+growth+factor+receptor+%28EGFR%29+tyrosine+kinases%3A+current+status+and+future+directions.&rft.au=Morabito%2C+Alessandro%3BPiccirillo%2C+Maria+Carmela%3BFalasconi%2C+Fabiano%3BDe+Feo%2C+Gianfranco%3BDel+Giudice%2C+Antonia%3BBryce%2C+Jane%3BDi+Maio%2C+Massimo%3BDe+Maio%2C+Ermelinda%3BNormanno%2C+Nicola%3BPerrone%2C+Francesco&rft.aulast=Morabito&rft.aufirst=Alessandro&rft.date=2009-04-01&rft.volume=14&rft.issue=4&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2008-0261 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-15 N1 - Date created - 2009-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2008-0261 ER - TY - JOUR T1 - Teen prescription drug abuse a major health concern. AN - 67156360; 19385366 JF - Tennessee medicine : journal of the Tennessee Medical Association AU - Volkow, Nora D AD - National Institute on Drug Abuse, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 28 EP - 29 VL - 102 IS - 4 SN - 1088-6222, 1088-6222 KW - Analgesics, Opioid KW - 0 KW - Prescription Drugs KW - Index Medicus KW - Humans KW - Adolescent KW - Consumer Health Information KW - Opioid-Related Disorders -- epidemiology KW - Adolescent Behavior KW - Analgesics, Opioid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67156360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tennessee+medicine+%3A+journal+of+the+Tennessee+Medical+Association&rft.atitle=Teen+prescription+drug+abuse+a+major+health+concern.&rft.au=Volkow%2C+Nora+D&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2009-04-01&rft.volume=102&rft.issue=4&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Tennessee+medicine+%3A+journal+of+the+Tennessee+Medical+Association&rft.issn=10886222&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-29 N1 - Date created - 2009-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Difference in phototoxicity of cyclodextrin complexed fullerene [(gamma-CyD)2/C60] and its aggregated derivatives toward human lens epithelial cells. AN - 67136142; 19281132 AB - The water-soluble fullerene derivative gamma-cyclodextrin bicapped C(60) [(gamma-CyD)(2)/C(60), CDF0] has several clinical applications, including use as a drug carrier to bypass the blood ocular barriers or a photosensitizer to treat tumors in photodynamic therapy. We have assessed the potential ocular toxicity of (gamma-CyD)(2)/C(60) and its aggregated derivatives induced by UVA and visible light in vitro in human lens epithelial cells (HLE B-3). Cell viability using the MTS assay demonstrated that 2 microM (gamma-CyD)(2)/C(60) was highly phototoxic to HLE B-3 cells with UVA irradiation, while no effect was observed in the presence of visible light or when maintained in the dark. In contrast, the aggregated derivative (CDF150) showed neither cytotoxicity nor any phototoxic effect even at 30 microM with either UVA or visible light irradiation. In lens cells treated with (gamma-CyD)(2)/C(60), phototoxicity was manifested as apoptosis. Singlet oxygen production measurement using the EPR/TEMP trapping technique determined that (gamma-CyD)(2)/C(60) (CDF0) efficiently produced singlet oxygen. The rate of singlet oxygen production decreased with increased aggregation, with no production by the fully aggregated sample formed after 150 min of heating (CDF150). UVA irradiation of HLE B-3 in the presence of (gamma-CyD)(2)/C(60) resulted in a significant rise in intracellular protein-derived peroxides. The singlet oxygen quenchers sodium azide and histidine each significantly protected lens cells against (gamma-CyD)(2)/C(60) photodamage, but lutein and Trolox (vitamin E) did not. Clearly, singlet oxygen is an important intermediate in the phototoxicity of monomeric (gamma-CyD)(2)/fullerene. Our results also demonstrate that UVA-blocking sunglasses can limit the ocular phototoxicity of this nanomaterial, while nontoxic endogenous antioxidants like lutein or Trolox cannot provide adequate protection. JF - Chemical research in toxicology AU - Zhao, Baozhong AU - He, Yu-Ying AU - Chignell, Colin F AU - Yin, Jun-Jie AU - Andley, Usha AU - Roberts, Joan E AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 660 EP - 667 VL - 22 IS - 4 KW - (gamma-CyD)2 C60 KW - 0 KW - Fullerenes KW - Photosensitizing Agents KW - gamma-Cyclodextrins KW - Singlet Oxygen KW - 17778-80-2 KW - Peroxidases KW - EC 1.11.1.- KW - gamma-cyclodextrin KW - KZJ0BYZ5VA KW - Index Medicus KW - Ultraviolet Rays KW - Singlet Oxygen -- metabolism KW - Humans KW - Electron Spin Resonance Spectroscopy KW - Temperature KW - Cell Line KW - Peroxidases -- metabolism KW - Fullerenes -- pharmacology KW - Photosensitizing Agents -- toxicity KW - Epithelial Cells -- drug effects KW - gamma-Cyclodextrins -- pharmacology KW - Lens, Crystalline -- cytology KW - Lens, Crystalline -- drug effects KW - gamma-Cyclodextrins -- toxicity KW - Fullerenes -- toxicity KW - Photosensitizing Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67136142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Difference+in+phototoxicity+of+cyclodextrin+complexed+fullerene+%5B%28gamma-CyD%292%2FC60%5D+and+its+aggregated+derivatives+toward+human+lens+epithelial+cells.&rft.au=Zhao%2C+Baozhong%3BHe%2C+Yu-Ying%3BChignell%2C+Colin+F%3BYin%2C+Jun-Jie%3BAndley%2C+Usha%3BRoberts%2C+Joan+E&rft.aulast=Zhao&rft.aufirst=Baozhong&rft.date=2009-04-01&rft.volume=22&rft.issue=4&rft.spage=660&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx800478u LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-07 N1 - Date created - 2009-04-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2004 Mar 18;428(6980):279-80 [15029186] J Photochem Photobiol B. 2002 Jul;67(3):157-62 [12167314] Nature. 1976 Sep 30;263(5576):442-3 [972689] Phys Med Biol. 1977 Mar;22(2):309-16 [857265] J Photochem Photobiol B. 1991 Jul;10(1-2):23-40 [1955945] BMJ. 1992 Aug 8;305(6849):335-9 [1392884] Antimicrob Agents Chemother. 1993 Aug;37(8):1707-10 [8215289] Invest Ophthalmol Vis Sci. 1994 Jun;35(7):3094-102 [8206728] Biochim Biophys Acta. 1994 Dec 30;1196(2):172-80 [7841181] J Exp Med. 1995 Nov 1;182(5):1545-56 [7595224] Invest Ophthalmol Vis Sci. 1995 Dec;36(13):2756-61 [7499098] Pharm Res. 1996 Feb;13(2):311-5 [8932455] Biosci Biotechnol Biochem. 1996 Aug;60(8):1359-61 [8987557] Genetika. 1997 Mar;33(3):405-9 [9244774] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9434-9 [9256500] Chem Biol. 1995 Jun;2(6):385-9 [9383440] Free Radic Biol Med. 2003 Mar 15;34(6):637-47 [12633741] Int J Toxicol. 2002 Nov-Dec;21(6):491-500 [12537645] Int J Toxicol. 2002 Nov-Dec;21(6):501-9 [12537646] Med Electron Microsc. 2002 Dec;35(4):234-41 [12658358] J Am Chem Soc. 2003 Oct 22;125(42):12803-9 [14558828] Acc Chem Res. 2003 Nov;36(11):807-15 [14622027] Histochem Cell Biol. 1998 Nov;110(5):467-76 [9826126] Anal Biochem. 1999 Sep 10;273(2):149-55 [10469484] Photochem Photobiol. 1999 Sep;70(3):353-8 [10483364] Photochem Photobiol. 2005 May-Jun;81(3):490-2 [15656701] Environ Sci Technol. 2005 Jun 1;39(11):4307-16 [15984814] Biomaterials. 2005 Dec;26(36):7587-95 [16005959] Photochem Photobiol. 2007 May-Jun;83(3):706-13 [17576381] Toxicol Appl Pharmacol. 2008 Apr 1;228(1):49-58 [18234258] Chem Res Toxicol. 2008 May;21(5):1056-63 [18422350] Photochem Photobiol. 2008 Sep-Oct;84(5):1215-23 [18399919] Exp Cell Res. 2000 Apr 10;256(1):328-37 [10739681] J Ocul Pharmacol Ther. 2000 Jun;16(3):285-97 [10872925] Acc Chem Res. 2000 Oct;33(10):695-703 [11041834] J Photochem Photobiol B. 2001 Nov 15;64(2-3):166-75 [11744403] Toxicol In Vitro. 2002 Feb;16(1):41-6 [11812638] Toxicol In Vitro. 2004 Oct;18(5):629-37 [15251181] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx800478u ER - TY - JOUR T1 - Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. AN - 67135447; 19256530 AB - Metabolic bioactivation, glutathione depletion, and covalent binding are the early hallmark events after acetaminophen (APAP) overdose. However, the subsequent metabolic consequences contributing to APAP-induced hepatic necrosis and apoptosis have not been fully elucidated. In this study, serum metabolomes of control and APAP-treated wild-type and Cyp2e1-null mice were examined by liquid chromatography-mass spectrometry (LC-MS) and multivariate data analysis. A dose-response study showed that the accumulation of long-chain acylcarnitines in serum contributes to the separation of wild-type mice undergoing APAP-induced hepatotoxicity from other mouse groups in a multivariate model. This observation, in conjunction with the increase of triglycerides and free fatty acids in the serum of APAP-treated wild-type mice, suggested that APAP treatment can disrupt fatty acid beta-oxidation. A time-course study further indicated that both wild-type and Cyp2e1-null mice had their serum acylcarnitine levels markedly elevated within the early hours of APAP treatment. While remaining high in wild-type mice, serum acylcarnitine levels gradually returned to normal in Cyp2e1-null mice at the end of the 24 h treatment. Distinct from serum aminotransferase activity and hepatic glutathione levels, the pattern of serum acylcarnitine accumulation suggested that acylcarnitines can function as complementary biomarkers for monitoring the APAP-induced hepatotoxicity. An essential role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the regulation of serum acylcarnitine levels was established by comparing the metabolomic responses of wild-type and Ppara-null mice to a fasting challenge. The upregulation of PPARalpha activity following APAP treatment was transient in wild-type mice but was much more prolonged in Cyp2e1-null mice. Overall, serum metabolomics of APAP-induced hepatotoxicity revealed that the CYP2E1-mediated metabolic activation and oxidative stress following APAP treatment can cause irreversible inhibition of fatty acid oxidation, potentially through suppression of PPARalpha-regulated pathways. JF - Chemical research in toxicology AU - Chen, Chi AU - Krausz, Kristopher W AU - Shah, Yatrik M AU - Idle, Jeffrey R AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 699 EP - 707 VL - 22 IS - 4 KW - Fatty Acids KW - 0 KW - PPAR alpha KW - acylcarnitine KW - Acetaminophen KW - 362O9ITL9D KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Glutathione KW - GAN16C9B8O KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Mass Spectrometry KW - Animals KW - Glutathione -- metabolism KW - Cytochrome P-450 CYP2E1 -- deficiency KW - Liver Diseases -- pathology KW - Chromatography, Liquid KW - Mice KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Time Factors KW - Mice, Knockout KW - Liver Diseases -- metabolism KW - Fatty Acids -- metabolism KW - Carnitine -- blood KW - Chemical and Drug Induced Liver Injury KW - PPAR alpha -- antagonists & inhibitors KW - PPAR alpha -- metabolism KW - Carnitine -- analogs & derivatives KW - Metabolomics KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67135447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Serum+metabolomics+reveals+irreversible+inhibition+of+fatty+acid+beta-oxidation+through+the+suppression+of+PPARalpha+activation+as+a+contributing+mechanism+of+acetaminophen-induced+hepatotoxicity.&rft.au=Chen%2C+Chi%3BKrausz%2C+Kristopher+W%3BShah%2C+Yatrik+M%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Chen&rft.aufirst=Chi&rft.date=2009-04-01&rft.volume=22&rft.issue=4&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx800464q LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-07 N1 - Date created - 2009-04-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Inherit Metab Dis. 2000 Mar;23(2):188-9 [10801061] Toxicol Sci. 2000 Oct;57(2):338-44 [11006363] J Inherit Metab Dis. 2000 Sep;23(6):571-82 [11032332] Toxicol Appl Pharmacol. 2000 Oct 15;168(2):114-22 [11032766] Toxicol Sci. 2002 Jan;65(1):135-50 [11752693] Lancet. 2002 Feb 16;359(9306):558-63 [11867109] J Inherit Metab Dis. 2002 Feb;25(1):17-27 [11999976] Hepatology. 2002 Sep;36(3):659-65 [12198658] Chem Res Toxicol. 2003 Mar;16(3):295-303 [12641429] Nat Rev Drug Discov. 2003 Aug;2(8):668-76 [12904817] FASEB J. 2003 Sep;17(12):1748-50 [12958197] J Pharm Biomed Anal. 2004 Apr 1;35(1):93-105 [15030884] Mol Aspects Med. 2004 Oct-Dec;25(5-6):521-32 [15363639] Toxicol Sci. 2004 Nov;82(1):318-32 [15282401] Toxicology. 1976 Jun;6(1):9-20 [941168] Biochem Pharmacol. 1983 Jul 1;32(13):1979-88 [6870927] Biochem Pharmacol. 1987 Feb 15;36(4):427-33 [3827934] Toxicol Appl Pharmacol. 1988 May;93(3):378-87 [3368917] Chem Biol Interact. 1990;75(2):201-11 [2369786] J Biol Chem. 1990 Dec 25;265(36):22313-6 [2266127] Chem Res Toxicol. 1993 Jul-Aug;6(4):511-8 [8374050] Biochim Biophys Acta. 1994 Jul 18;1226(3):269-76 [8054358] Mol Cell Biol. 1995 Jun;15(6):3012-22 [7539101] Pharmacol Ther. 1995;67(1):101-54 [7494860] J Biol Chem. 1996 May 17;271(20):12063-7 [8662637] Fundam Appl Toxicol. 1996 Feb;29(2):229-37 [8742320] Toxicol Appl Pharmacol. 1996 Nov;141(1):299-307 [8917703] Physiol Rev. 1997 Apr;77(2):517-44 [9114822] J Biol Chem. 1998 Jul 10;273(28):17940-53 [9651401] J Clin Invest. 1999 Jun;103(11):1489-98 [10359558] Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7473-8 [10377439] J Toxicol Environ Health A. 1999 Oct 15;58(3):171-86 [10522648] Ann N Y Acad Sci. 2004 Nov;1033:1-16 [15590999] J Hepatol. 2005 Jan;42(1):110-6 [15629515] J Pharmacol Exp Ther. 2005 Feb;312(2):509-16 [15466245] Drug Metab Dispos. 2005 Mar;33(3):449-57 [15576447] Hepatology. 2005 Dec;42(6):1364-72 [16317692] J Biol Chem. 2005 Dec 23;280(51):42464-75 [16227625] J Biol Chem. 2006 Jun 16;281(24):16768-76 [16608839] Eur J Pharmacol. 2007 May 7;562(1-2):68-71 [17331495] Biochim Biophys Acta. 2007 Aug;1771(8):952-60 [17560826] Drug Metab Rev. 2007;39(2-3):581-97 [17786640] Exp Toxicol Pathol. 2007 Oct;59(2):121-8 [17716880] J Biol Chem. 2008 Feb 22;283(8):4543-59 [18093979] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx800464q ER - TY - JOUR T1 - Autoimmunity and hematologic malignancies: associations and mechanisms. AN - 67135395; 19373651 AB - Although the true prevalence of autoimmune diseases remains to be better defined, in Western countries the current estimates indicate that at least 5% of the population is affected by an autoimmune disorder. Over the last few decades, autoimmune diseases have been associated with an elevated risk of developing lymphoproliferative malignancies, particularly non-Hodgkin lymphomas. Some studies have found the relationship between autoimmunity and lymphoproliferative tumors to be bi-directional. Although substantial work has been carried out to characterise the associations between autoimmunity and lymphoproliferation, current insights regarding underlying biological mechanisms remain limited and hence present a gap in the literature. In this article, we review reported main associations between selected common autoimmune diseases and lymphoproliferative neoplasms. We also discuss potential underlying mechanisms that have been proposed to connect these two disorders. Finally, we provide future directions for new research studies aimed to improve our understanding of inflammation and the dysregulated immune system in the development of autoimmunity and hematologic malignancies. JF - Leukemia & lymphoma AU - Martin, Damali N AU - Mikhail, Isis S AU - Landgren, Ola AD - Division of Cancer Control and Population Sciences, Center for Cancer Research, National Cancer Institute, Bethesda, Rockville, MD 20852-7324, USA. martinda@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 541 EP - 550 VL - 50 IS - 4 KW - Index Medicus KW - Lymphoma, Non-Hodgkin -- genetics KW - Genetic Predisposition to Disease -- genetics KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Lymphoma, Non-Hodgkin -- etiology KW - Lymphoma, Non-Hodgkin -- immunology KW - Models, Biological KW - Inflammation -- complications KW - Infection -- complications KW - Autoimmunity -- immunology KW - Hematologic Neoplasms -- etiology KW - Hematologic Neoplasms -- genetics KW - Hematologic Neoplasms -- immunology KW - Autoimmune Diseases -- immunology KW - Autoimmune Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67135395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Autoimmunity+and+hematologic+malignancies%3A+associations+and+mechanisms.&rft.au=Martin%2C+Damali+N%3BMikhail%2C+Isis+S%3BLandgren%2C+Ola&rft.aulast=Martin&rft.aufirst=Damali&rft.date=2009-04-01&rft.volume=50&rft.issue=4&rft.spage=541&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=1029-2403&rft_id=info:doi/10.1080%2F10428190902780677 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-25 N1 - Date created - 2009-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10428190902780677 ER - TY - JOUR T1 - Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis. AN - 67124486; 19364932 AB - Maintenance therapy with anti-CD25 antibody has emerged as a potentially useful treatment for multiple sclerosis (MS). Constitutive CD25 expression on CD4+CD25+ regulatory T cells (Treg) suggests that anti-CD25 antibody treatment may potentially target a subset of T cells that exhibit immune suppressive properties. We examined changes to CD4+CD25+ Treg in patients with MS receiving maintenance anti-CD25 monoclonal antibody treatment to determine the effect of treatment on Treg and, consequently, on immunological tolerance. Peripheral blood and cerebrospinal fluid samples obtained from a before-and-after trial of anti-CD25 antibody monotherapy were examined to compare baseline and treatment differences in CD4+CD25+ Treg. A total of 15 subjects with MS. One subject was withdrawn owing to an adverse effect. Sustained reduction of the frequency of CD4+CD25+ Treg was observed during treatment. Anti-CD25 antibody treatment led to evidence of impaired in vivo Treg proliferation and impaired ex vivo Treg suppression. Inflammatory MS activity was substantially reduced with treatment despite reduction of circulating Treg, and there was no correlation between changes in the frequency of Treg and changes in brain inflammatory activity. However, new-onset inflammatory disease, notably dermatitis, was also observed in a number of subjects during treatment. The reduction in Treg did not negatively affect maintenance of central nervous system tolerance during anti-CD25 antibody treatment. The incidence of new-onset inflammatory disease outside of the central nervous system in a subset of patients, however, warrants further studies to examine the possibility of compartmental differences in the capacity to maintain tolerance in the setting of reduced CD4+CD25+ Treg. JF - Archives of neurology AU - Oh, Unsong AU - Blevins, Gregg AU - Griffith, Caitlin AU - Richert, Nancy AU - Maric, Dragan AU - Lee, C Richard AU - McFarland, Henry AU - Jacobson, Steven AD - Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke (NINDS), National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 471 EP - 479 VL - 66 IS - 4 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Immunoglobulin G KW - Immunosuppressive Agents KW - Interleukin-2 Receptor alpha Subunit KW - daclizumab KW - CUJ2MVI71Y KW - Abridged Index Medicus KW - Index Medicus KW - Magnetic Resonance Imaging KW - Young Adult KW - Drug Eruptions -- etiology KW - Infusions, Intravenous KW - Brain -- drug effects KW - Humans KW - Brain -- immunology KW - CD4 Lymphocyte Count KW - Self Tolerance -- drug effects KW - Self Tolerance -- immunology KW - Lymphocyte Activation -- drug effects KW - Drug Eruptions -- immunology KW - Lymphocyte Activation -- immunology KW - Brain -- pathology KW - Adult KW - Middle Aged KW - Long-Term Care KW - Flow Cytometry KW - Male KW - Female KW - Immunoglobulin G -- adverse effects KW - T-Lymphocytes, Regulatory -- drug effects KW - Multiple Sclerosis -- drug therapy KW - CD4-Positive T-Lymphocytes -- immunology KW - CD4-Positive T-Lymphocytes -- drug effects KW - Immunoglobulin G -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use KW - Antibodies, Monoclonal -- adverse effects KW - Interleukin-2 Receptor alpha Subunit -- immunology KW - Multiple Sclerosis -- immunology KW - Immunosuppressive Agents -- therapeutic use KW - T-Lymphocytes, Regulatory -- immunology KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67124486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+neurology&rft.atitle=Regulatory+T+cells+are+reduced+during+anti-CD25+antibody+treatment+of+multiple+sclerosis.&rft.au=Oh%2C+Unsong%3BBlevins%2C+Gregg%3BGriffith%2C+Caitlin%3BRichert%2C+Nancy%3BMaric%2C+Dragan%3BLee%2C+C+Richard%3BMcFarland%2C+Henry%3BJacobson%2C+Steven&rft.aulast=Oh&rft.aufirst=Unsong&rft.date=2009-04-01&rft.volume=66&rft.issue=4&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Archives+of+neurology&rft.issn=1538-3687&rft_id=info:doi/10.1001%2Farchneurol.2009.16 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-24 N1 - Date created - 2009-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1994 Dec 8;372(6506):570-3 [7990932] Eur J Immunol. 2005 Nov;35(11):3343-52 [16206232] J Immunol. 2005 Jan 1;174(1):164-73 [15611238] Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5138-43 [15790681] Immunity. 2005 Mar;22(3):329-41 [15780990] Blood. 2006 Mar 15;107(6):2409-14 [16304057] Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5941-6 [16585503] J Neurosci Res. 2006 Jun;83(8):1432-46 [16583400] J Exp Med. 2006 Jul 10;203(7):1693-700 [16818676] J Exp Med. 2006 Jul 10;203(7):1701-11 [16818678] Blood. 2006 Sep 1;108(5):1571-9 [16645171] J Clin Invest. 2006 Sep;116(9):2423-33 [16955142] J Immunol. 2006 Oct 1;177(7):4488-94 [16982885] Am J Transplant. 2007 Jan;7(1):249-55 [17109733] J Immunol. 2007 Feb 15;178(4):2579-88 [17277168] J Clin Immunol. 2007 Jan;27(1):1-18 [17216565] Nat Med. 2007 Apr;13(4):423-31 [17384649] Blood. 2007 May 15;109(10):4368-75 [17227828] J Exp Med. 2007 Jun 11;204(6):1335-47 [17548521] J Immunol. 2007 Jul 15;179(2):1322-30 [17617625] J Histochem Cytochem. 2007 Sep;55(9):891-8 [17478450] Neurology. 2007 Aug 21;69(8):785-9 [17709711] Blood. 2007 Sep 1;110(5):1603-6 [17463169] Nat Genet. 2001 Jan;27(1):20-1 [11137993] J Exp Med. 2001 Jun 4;193(11):F41-6 [11390442] Ann Neurol. 2001 Jul;50(1):121-7 [11456302] J Immunol. 2001 Aug 1;167(3):1245-53 [11466340] J Autoimmun. 2003 Nov;21(3):283-93 [14599854] Annu Rev Immunol. 2004;22:531-62 [15032588] J Exp Med. 2004 Apr 5;199(7):971-9 [15067033] Arch Dermatol. 2004 Apr;140(4):466-72 [15096376] Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8705-8 [15161974] Int Immunol. 2004 Nov;16(11):1643-56 [15466453] Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15434-9 [15492218] J Immunol. 1984 Oct;133(4):1710-5 [6206131] Immunol Today. 1993 Jun;14(6):264-70 [8397768] J Exp Med. 1994 Mar 1;179(3):973-84 [7509366] N Engl J Med. 1998 Jan 15;338(3):161-5 [9428817] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archneurol.2009.16 ER - TY - JOUR T1 - Nitric oxide synthase gene polymorphisms and prostate cancer risk. AN - 67119149; 19168583 AB - Nitric oxide (NO) induces cytotoxicity and angiogenesis, and may play a role in prostate carcinogenesis, potentially modulated by environmental exposures. We evaluated the association of prostate cancer with genetic polymorphisms in two genes related to intracellular NO: NOS2A [inducible nitric oxide synthase (NOS); -2892T>C, Ex16 + 14C>T (S608L), IVS16 + 88T>G and IVS20 + 524G>A] and NOS3 [endothelial NOS; IVS1-762C>T, Ex7-43C>T (D258D), IVS7-26A>G, Ex8-63G>T (E298D) and IVS15-62G>T]. Prostate cancer cases (n = 1320) from the screening arm of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial were frequency matched to controls (n = 1842), by age, race, time since initial screening and year of blood draw. An antioxidant score [range 3-12; low (3-7) versus high (8-12)] was created by summing the quartile levels of vitamin E, beta-carotene and lycopene, which were coded from 1 to 4, respectively. The global tests for all eight single-nucleotide polymorphisms (SNPs) (excluding NOS2A-2892T>C, with low minor allele frequency) were statistically significant for prostate cancer (P = 0.005), especially for aggressive cancer (stage III-IV or Gleason score > or = 7) (P = 0.01). The NOS2A IVS16 + 88 GT/TT was associated with increased prostate cancer risk (odds ratio = 1.24, 95% confidence interval = 1.00-1.54), whereas the IVS20 + 524 AG/GG was associated with decreased risk (0.77, 0.66-0.90). The NOS3 IVS7-26GG was associated with increased prostate cancer risk (1.33, 1.07-1.64). All these SNPs showed significant associations with aggressive cancer and not for non-aggressive cancer. In the evaluation of effect modification, the effect of the NOS2A IVS16 + 88 GT/TT on aggressive cancer was stronger among subjects with higher antioxidant intake (1.61, 1.18-2.19; P(interaction) = 0.01). Our results suggest that NOS gene polymorphisms are genetic susceptibility factors for aggressive prostate cancer. JF - Carcinogenesis AU - Lee, Kyoung-Mu AU - Kang, Daehee AU - Park, Sue Kyung AU - Berndt, Sonja I AU - Reding, Douglas AU - Chatterjee, Nilanjan AU - Chanock, Stephen AU - Huang, Wen-Yi AU - Hayes, Richard B AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. leekyou@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 621 EP - 625 VL - 30 IS - 4 KW - Antioxidants KW - 0 KW - beta Carotene KW - 01YAE03M7J KW - Vitamin E KW - 1406-18-4 KW - Carotenoids KW - 36-88-4 KW - NOS2 protein, human KW - EC 1.14.13.39 KW - NOS3 protein, human KW - Nitric Oxide Synthase Type II KW - Nitric Oxide Synthase Type III KW - lycopene KW - SB0N2N0WV6 KW - Index Medicus KW - beta Carotene -- administration & dosage KW - Genotype KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Carotenoids -- administration & dosage KW - Vitamin E -- administration & dosage KW - Male KW - Nitric Oxide Synthase Type III -- genetics KW - Polymorphism, Genetic -- genetics KW - Prostatic Neoplasms -- blood KW - Prostatic Neoplasms -- genetics KW - Prostatic Neoplasms -- prevention & control KW - Nitric Oxide Synthase Type II -- genetics KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67119149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Nitric+oxide+synthase+gene+polymorphisms+and+prostate+cancer+risk.&rft.au=Lee%2C+Kyoung-Mu%3BKang%2C+Daehee%3BPark%2C+Sue+Kyung%3BBerndt%2C+Sonja+I%3BReding%2C+Douglas%3BChatterjee%2C+Nilanjan%3BChanock%2C+Stephen%3BHuang%2C+Wen-Yi%3BHayes%2C+Richard+B&rft.aulast=Lee&rft.aufirst=Kyoung-Mu&rft.date=2009-04-01&rft.volume=30&rft.issue=4&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-28 N1 - Date created - 2009-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Antioxid Redox Signal. 2001 Apr;3(2):203-13 [11396476] Eur J Cancer Prev. 2002 Aug;11(4):343-50 [12195160] J Hypertens. 2002 Oct;20(10):2023-7 [12359981] Cancer Lett. 2003 Jan 10;189(1):85-90 [12445681] Int J Cancer. 2003 Apr 10;104(3):274-82 [12569550] Cancer Lett. 2004 Jul 8;210(1):63-71 [15172122] Cancer Metastasis Rev. 1998 Mar;17(1):91-106 [9544425] Cancer. 1998 May 15;82(10):1897-903 [9587122] Carcinogenesis. 1998 May;19(5):711-21 [9635855] J Clin Oncol. 2005 Jan 10;23(2):368-77 [15637399] Exp Mol Med. 2005 Oct 31;37(5):497-506 [16264276] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Cancer Res. 2006 Jul 1;66(13):6459-62 [16818612] Lancet Oncol. 2007 Feb;8(2):111-8 [17267325] Oncogene. 2007 Mar 22;26(13):1875-84 [16983333] Nat Genet. 2007 May;39(5):645-9 [17401363] Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1581-6 [17646272] J Natl Cancer Inst. 2007 Oct 17;99(20):1525-33 [17925536] Breast Cancer Res Treat. 2007 Dec;106(3):433-8 [17262178] J Natl Cancer Inst. 2007 Dec 19;99(24):1836-44 [18073375] Nat Genet. 2008 Mar;40(3):310-5 [18264096] Urol Res. 2001 Feb;29(1):23-8 [11310211] Gynecol Oncol. 2002 Aug;86(2):134-7 [12144818] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp028 ER - TY - JOUR T1 - Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China. AN - 67117691; 19168589 AB - Biliary tract cancers, encompassing gallbladder, extrahepatic bile duct and ampulla of Vater cancers, are uncommon but often fatal malignancies. Hormone-related factors, including parity, oral contraceptive use, obesity, and gallstones, have been implicated in the etiology of these cancers. To further clarify the role of hormones in biliary tract cancers and biliary stones, we genotyped 18 single-nucleotide polymorphisms (SNPs) in nine genes involved in steroid hormone biosynthesis, metabolism and transport in a population-based case-control study in Shanghai, China. This study included subjects who completed an interview and provided blood, which totaled 411 biliary tract cancer and 893 biliary stone patients and 786 healthy Shanghai residents. The CYP1A1 IVS1 + 606 (rs2606345) T allele was associated with gallbladder [odds ratio (OR) = 2.0, 95% confidence interval (CI), 1.3-3.0] and bile duct cancers (OR = 1.8, 95% CI = 1.1-3.1), whereas the CYP1A1 Ex7 + 131 (rs1048943) G allele was associated with ampulla of Vater cancer (OR = 2.9, 95% CI = 1.5-5.4). After taking into account multiple comparisons for SNPs within each gene, CYP1A1 was significantly associated with gallbladder (P = 0.004) and ampulla of Vater cancers (P = 0.01), but borderline with bile duct cancer (P = 0.06). The effect of CYP1A1 IVS1 + 606 on gallbladder cancer was more pronounced among non-obese (body mass index < 23) (OR = 3.3, 95% CI = 1.8-6.1; P interaction = 0.001). Among women taking oral contraceptives, the effect of SHBG Ex8 + 6 (rs6259) on gallbladder cancer (OR = 6.7, 95% CI = 2.2-20.5; P interaction = 0.001) and stones (OR = 2.3, 95% CI = 1.1-4.9; P-interaction = 0.05) was statistically significant. Our findings suggest that common variants in hormone-related genes contribute to the risk of biliary tract cancers and stones, possibly by modulating hormone metabolism. JF - Carcinogenesis AU - Park, Sue K AU - Andreotti, Gabriella AU - Sakoda, Lori C AU - Gao, Yu-Tang AU - Rashid, Asif AU - Chen, Jinbo AU - Chen, Bingshu E AU - Rosenberg, Philip S AU - Shen, Ming-Chang AU - Wang, Bing-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Yeager, Meredith AU - Chanock, Stephen AU - Hsing, Ann W AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, EPS 5024, MSC 7234, Bethesda, MD 20892-7234, USA. suepark@snu.ac.kr Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 606 EP - 614 VL - 30 IS - 4 KW - Biomarkers, Tumor KW - 0 KW - Contraceptives, Oral, Hormonal KW - Hormones KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Index Medicus KW - Humans KW - Prognosis KW - Aged KW - Body Mass Index KW - Risk Factors KW - China -- epidemiology KW - DNA -- blood KW - Adult KW - DNA -- genetics KW - Case-Control Studies KW - Interviews as Topic KW - Middle Aged KW - Contraceptives, Oral, Hormonal -- administration & dosage KW - Female KW - Male KW - Gallstones -- epidemiology KW - Biomarkers, Tumor -- genetics KW - Cytochrome P-450 CYP1A1 -- genetics KW - Biliary Tract Neoplasms -- epidemiology KW - Biliary Tract Neoplasms -- blood KW - Biliary Tract Neoplasms -- genetics KW - Gallstones -- blood KW - Hormones -- metabolism KW - Polymorphism, Single Nucleotide -- genetics KW - Gallstones -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67117691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Variants+in+hormone-related+genes+and+the+risk+of+biliary+tract+cancers+and+stones%3A+a+population-based+study+in+China.&rft.au=Park%2C+Sue+K%3BAndreotti%2C+Gabriella%3BSakoda%2C+Lori+C%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BChen%2C+Jinbo%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip+S%3BShen%2C+Ming-Chang%3BWang%2C+Bing-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BYeager%2C+Meredith%3BChanock%2C+Stephen%3BHsing%2C+Ann+W&rft.aulast=Park&rft.aufirst=Sue&rft.date=2009-04-01&rft.volume=30&rft.issue=4&rft.spage=606&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-28 N1 - Date created - 2009-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):3-28 [10667460] Menopause. 2000 May-Jun;7(3):162-7 [10810961] Pharmacogenetics. 2000 Aug;10(6):519-30 [10975606] Ann Intern Med. 2001 Oct 2;135(7):493-501 [11578152] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Trends Endocrinol Metab. 2002 Apr;13(3):122-8 [11893526] J Exp Clin Cancer Res. 2002 Mar;21(1):119-24 [12071517] Int J Cancer. 2002 Jun 10;99(5):762-3 [12115514] J Endocrinol Invest. 2002 Nov;25(10):893-8 [12508952] Int J Cancer. 2003 Jun 20;105(3):408-12 [12704678] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D528-32 [14681474] Acta Endocrinol Suppl (Copenh). 1980;232:1-127 [6770572] Recent Prog Horm Res. 1982;38:457-510 [6750727] J Natl Cancer Inst. 1985 Apr;74(4):741-5 [3857369] Cancer. 1987 Jun 15;59(12):2112-6 [3567872] Jpn J Cancer Res. 1989 Oct;80(10):932-8 [2515177] J Clin Epidemiol. 1990;43(7):687-92 [2370576] J Clin Invest. 1991 Jan;87(1):237-46 [1845870] Contraception. 1991 Jun;43(6):667-93 [1868737] J Toxicol Environ Health. 1993 Oct-Nov;40(2-3):309-16 [7901425] Int J Cancer. 1994 Apr 15;57(2):146-53 [8157350] Cancer Causes Control. 1994 May;5(3):267-72 [8061176] Toxicol Lett. 1995 May;77(1-3):357-62 [7618162] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Eur J Cancer Prev. 1996 Aug;5(4):241-7 [8894561] J Cell Biochem Suppl. 1996;25:15-22 [9027593] J Natl Cancer Inst. 1997 Aug 6;89(15):1132-8 [9262251] Int J Cancer. 1998 Jan 30;75(3):368-70 [9455795] Am J Gastroenterol. 1999 Jan;94(1):149-52 [9934746] Hepatogastroenterology. 1999 May-Jun;46(27):1529-32 [10430289] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Expert Opin Drug Saf. 2006 Jan;5(1):117-29 [16370961] J Sex Med. 2006 Jan;3(1):104-13 [16409223] Int J Cancer. 2006 Apr 1;118(7):1591-602 [16397865] Int J Cancer. 2006 Jun 1;118(11):2847-53 [16381022] Fertil Steril. 2006 May;85(5):1319-40 [16647374] Carcinogenesis. 2006 Jun;27(6):1251-6 [16361272] Stat Med. 2006 Sep 30;25(18):3134-49 [16252274] J Gastroenterol Hepatol. 2006 Nov;21(11):1737-43 [16984599] Br J Cancer. 2007 Dec 3;97(11):1577-82 [18000509] Int J Cancer. 2008 Apr 15;122(8):1849-53 [18076042] Cancer Res. 2008 Aug 1;68(15):6442-52 [18676870] Br J Cancer. 2008 Sep 2;99(5):811-5 [18728671] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp024 ER - TY - JOUR T1 - Precursor-product discrimination by La protein during tRNA metabolism. AN - 67114163; 19287396 AB - La proteins bind pre-tRNAs at their UUU-3'OH ends, facilitating their maturation. Although the mechanism by which La binds pre-tRNA 3' trailers is known, the function of the RNA binding beta-sheet surface of the RNA-recognition motif (RRM1) is unknown. How La dissociates from UUU-3'OH-containing trailers after 3' processing is also unknown. Here we show that La preferentially binds pre-tRNAs over processed tRNAs or 3' trailer products through coupled use of two sites: one on the La motif and another on the RRM1 beta-surface that binds elsewhere on tRNA. Two sites provide stable pre-tRNA binding, whereas the processed tRNA and 3' trailer are released from their single sites relatively fast. RRM1 loop-3 mutations decrease affinity for pre-tRNA and tRNA, but not for the UUU-3'OH trailer, and impair tRNA maturation in vivo. We propose that RRM1 functions in activities that are more complex than UUU-3'OH binding. Accordingly, the RRM1 mutations also impair an RNA chaperone activity of La. The results suggest how La distinguishes precursor from product RNAs, allowing it to recycle onto a new pre-tRNA. JF - Nature structural & molecular biology AU - Bayfield, Mark A AU - Maraia, Richard J AD - Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 430 EP - 437 VL - 16 IS - 4 KW - Autoantigens KW - 0 KW - RNA Precursors KW - RNA-Binding Proteins KW - Ribonucleoproteins KW - SS-B antigen KW - RNA, Transfer KW - 9014-25-9 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Amino Acid Substitution -- genetics KW - Kinetics KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Protein Binding KW - Models, Biological KW - Binding Sites KW - RNA Precursors -- metabolism KW - RNA-Binding Proteins -- metabolism KW - RNA, Transfer -- metabolism KW - Ribonucleoproteins -- chemistry KW - Ribonucleoproteins -- metabolism KW - RNA-Binding Proteins -- chemistry KW - Autoantigens -- metabolism KW - Autoantigens -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67114163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+structural+%26+molecular+biology&rft.atitle=Precursor-product+discrimination+by+La+protein+during+tRNA+metabolism.&rft.au=Bayfield%2C+Mark+A%3BMaraia%2C+Richard+J&rft.aulast=Bayfield&rft.aufirst=Mark&rft.date=2009-04-01&rft.volume=16&rft.issue=4&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Nature+structural+%26+molecular+biology&rft.issn=1545-9985&rft_id=info:doi/10.1038%2Fnsmb.1573 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-16 N1 - Date created - 2009-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 1997 Sep 15;11(18):2371-82 [9308965] Mol Cell Biol. 2005 Jan;25(2):621-36 [15632064] Mol Cell. 2000 Aug;6(2):339-48 [10983981] Nat Struct Biol. 2000 Oct;7(10):847-50 [11017190] EMBO J. 2000 Nov 15;19(22):6230-9 [11080168] Mol Cell Biol. 2001 Jan;21(2):367-79 [11134326] J Biol Chem. 2001 Jul 20;276(29):27188-96 [11342556] J Mol Biol. 2001 Oct 5;312(5):975-84 [11580243] Gene Expr. 2002;10(1-2):41-57 [11868987] RNA. 2002 Mar;8(3):324-35 [12003492] Annu Rev Biochem. 2002;71:375-403 [12045101] Mol Cell. 2002 May;9(5):1113-23 [12049746] Genes Dev. 2003 Jan 15;17(2):162-80 [12533506] Biochemistry. 2003 May 20;42(19):5736-47 [12741831] EMBO J. 2003 Dec 15;22(24):6562-72 [14657028] EMBO J. 2004 Mar 10;23(5):1000-7 [14976553] Nat Struct Mol Biol. 2004 Apr;11(4):323-9 [15004549] Nat Struct Mol Biol. 2004 Apr;11(4):303-5 [15048103] J Biol Chem. 2004 Jun 18;279(25):26563-70 [15060081] J Mol Biol. 1981 Jan 15;145(2):405-20 [7196457] Mol Cell Biol. 1981 Dec;1(12):1138-49 [6180298] Biochim Biophys Acta. 1987 Apr 22;928(2):217-26 [2436670] Cell. 1997 May 2;89(3):393-402 [9150139] Mol Cell Biol. 1997 Oct;17(10):5823-32 [9315640] RNA. 1997 Dec;3(12):1434-43 [9404894] Biochemistry. 1998 Nov 17;37(46):16349-59 [9819227] Genes Dev. 1998 Dec 1;12(23):3650-62 [9851972] Mol Cell Biol. 1999 Jun;19(6):4167-81 [10330157] Nat Rev Mol Cell Biol. 2004 Nov;5(11):908-19 [15520810] Nat Struct Mol Biol. 2004 Dec;11(12):1206-14 [15531892] FEBS J. 2005 May;272(9):2118-31 [15853797] Annu Rev Biophys Biomol Struct. 2005;34:221-43 [15869389] RNA. 2005 Jul;11(7):1084-94 [15928345] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11127-8 [16061803] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18350-5 [16344466] Mol Cell. 2006 Jan 6;21(1):75-85 [16387655] Mol Cell. 2006 Jan 20;21(2):149-52 [16427005] RNA. 2006 Apr;12(4):644-54 [16581807] Trends Biochem Sci. 2006 Jun;31(6):303-5 [16679019] Nat Struct Mol Biol. 2006 Jul;13(7):611-8 [16799560] Nucleic Acids Res. 2006;34(17):4826-36 [16971453] Nature. 2007 Mar 22;446(7134):458-61 [17322903] Mol Cell Biol. 2007 May;27(9):3303-12 [17308035] RNA. 2007 Dec;13(12):2053-60 [17901153] Mol Cell. 2008 Mar 14;29(5):588-99 [18249148] Nucleic Acids Res. 2008 Apr;36(7):2219-29 [18281698] Structure. 2008 Jun;16(6):852-62 [18547518] Mol Cell Biol. 2008 Jul;28(14):4576-87 [18474615] Methods Mol Biol. 1999;118:115-28 [10549519] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nsmb.1573 ER - TY - JOUR T1 - The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers. AN - 67113119; 19336734 AB - Myoinositol is an isomer of glucose that has chemopreventive activity in animal models of cancer. In a recent phase I clinical trial, myoinositol administration correlated with a statistically significant regression of preexisting bronchial dysplastic lesions in heavy smokers. To shed light on the potential mechanisms involved, activation of Akt and extracellular signal-regulated kinase (ERK), two kinases that control cellular proliferation and survival, was assessed in 206 paired bronchial biopsies from 21 patients who participated in this clinical trial. Before myoinositol treatment, strongly positive staining for activation of Akt was detected in 27% of hyperplastic/metaplastic lesions and 58% of dysplastic lesions (P = 0.05, chi(2) test). There was also a trend toward increased activation of ERK (28% in regions of hyperplasia/metaplasia to 42% of dysplastic lesions). Following myoinositol treatment, significant decreases in Akt and ERK phosphorylation were observed in dysplastic (P 0.05). In vitro, myoinositol decreased endogenous and tobacco carcinogen-induced activation of Akt and ERK in immortalized human bronchial epithelial cells, which decreased cell proliferation and induced a G(1)-S cell cycle arrest. These results show that the phenotypic progression of premalignant bronchial lesions from smokers correlates with increased activation of Akt and ERK and that these kinases are targets of myoinositol. Moreover, they suggest that myoinositol might cause regression of bronchial dysplastic lesions through inhibition of active Akt and ERK. JF - Cancer prevention research (Philadelphia, Pa.) AU - Han, Wei AU - Gills, Joell J AU - Memmott, Regan M AU - Lam, Stephen AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20889, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 370 EP - 376 VL - 2 IS - 4 KW - Antineoplastic Agents KW - 0 KW - Inositol KW - 4L6452S749 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Humans KW - Aged KW - Precancerous Conditions -- drug therapy KW - Precancerous Conditions -- enzymology KW - Lung Neoplasms -- prevention & control KW - Phosphorylation KW - Adult KW - Middle Aged KW - Immunohistochemistry KW - Cell Line KW - Female KW - Male KW - Inositol -- therapeutic use KW - Proto-Oncogene Proteins c-akt -- drug effects KW - Extracellular Signal-Regulated MAP Kinases -- biosynthesis KW - Bronchial Diseases -- drug therapy KW - Smoking -- adverse effects KW - Bronchial Diseases -- enzymology KW - Antineoplastic Agents -- therapeutic use KW - Proto-Oncogene Proteins c-akt -- biosynthesis KW - Extracellular Signal-Regulated MAP Kinases -- drug effects KW - Bronchial Diseases -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67113119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=The+chemopreventive+agent+myoinositol+inhibits+Akt+and+extracellular+signal-regulated+kinase+in+bronchial+lesions+from+heavy+smokers.&rft.au=Han%2C+Wei%3BGills%2C+Joell+J%3BMemmott%2C+Regan+M%3BLam%2C+Stephen%3BDennis%2C+Phillip+A&rft.aulast=Han&rft.aufirst=Wei&rft.date=2009-04-01&rft.volume=2&rft.issue=4&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-08-0209 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-23 N1 - Date created - 2009-04-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anticancer Res. 1999 Sep-Oct;19(5A):3743-7 [10625951] PLoS One. 2008;3(8):e2850 [18682746] Cancer Lett. 2001 Jun 10;167(1):1-6 [11323092] J Neurochem. 2001 Nov;79(3):489-98 [11701752] Cancer. 2001 Sep 15;92(6):1525-30 [11745231] Curr Opin Oncol. 2002 Mar;14(2):185-90 [11880709] Carcinogenesis. 2002 Sep;23(9):1455-61 [12189187] J Clin Invest. 2003 Jan;111(1):81-90 [12511591] Ann Clin Biochem. 2003 Jan;40(Pt 1):79-85 [12542915] Clin Cancer Res. 2003 Jun;9(6):2241-7 [12796392] Cancer Epidemiol Biomarkers Prev. 2003 Jul;12(7):660-4 [12869408] Br J Cancer. 2004 Mar 8;90(5):1047-52 [14997206] Oncogene. 2004 Mar 4;23(9):1754-65 [14755253] Cancer Res. 2004 Apr 15;64(8):2782-92 [15087394] FASEB J. 2004 Sep;18(12):1436-8 [15247149] Am J Clin Nutr. 1980 Sep;33(9):1954-67 [7416064] Annu Rev Nutr. 1986;6:563-97 [2425833] Pediatr Res. 1994 Feb;35(2):141-7 [8165046] Eur Neuropsychopharmacol. 1997 May;7(2):147-55 [9169302] Cancer Res. 1997 Jul 15;57(14):2873-8 [9230193] Carcinogenesis. 1998 Apr;19(4):551-6 [9600337] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8773-8 [9671754] Cancer Res. 2004 Dec 15;64(24):9027-34 [15604268] Biochem Biophys Res Commun. 2005 Apr 1;329(1):58-63 [15721273] Oncogene. 2005 Apr 21;24(18):3042-9 [15846305] Breast Cancer Res Treat. 2005 May;91(1):35-45 [15868430] Carcinogenesis. 2005 Jul;26(7):1182-95 [15790591] J Clin Oncol. 2006 Jan 10;24(2):306-14 [16330671] Cancer Res. 2006 Feb 15;66(4):2116-28 [16489012] Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1526-31 [16896044] Int J Cancer. 2006 Oct 1;119(7):1547-52 [16671086] Nutr Cancer. 2006;55(2):109-25 [17044765] Carcinogenesis. 2007 Feb;28(2):446-54 [16973672] Int J Chron Obstruct Pulmon Dis. 2006;1(1):31-8 [18046900] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Curr Biol. 2000 Apr 20;10(8):439-48 [10801415] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-08-0209 ER - TY - JOUR T1 - Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer. AN - 67109562; 19318490 AB - Gefitinib targeting of the epidermal growth factor receptor (EGFR) has shown limited activity in clinical trials of head and neck squamous cell carcinoma (HNSCC). To investigate the underlying molecular mechanism, the proteomic signatures and responses of EGFR and downstream signals have been studied in a panel of HNSCC cell lines and tumor specimens pre- and post-gefitinib treatment. The IC(50) of gefitinib for HNSCC cell lines were determined using 3-(4,5-dmethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide proliferation assay. The effects of gefitinib on activation of EGFR and downstream signaling molecules were determined by Western blot, ELISA, and reverse-phase protein microarray (RPMA). The biomarkers involved in the signaling pathways were examined in HNSCC tumor specimens from patients in a phase I gefitinib trial. In vitro, gefitinib inhibited cell proliferation with differing IC(50), and suppressed activation of EGFR and downstream signaling molecules protein kinase B (AKT), extracellular signal-regulated kinase 1/2, signal transducer and activator of transcription 3 (STAT3), and nuclear factor kappaB. The drug sensitivity was statistically correlated with activation of phosphorylated AKT (p-AKT) and phosphorylated STAT3 (p-STAT3) detected by ELISA, and consistent with results measured by RPMA. In patient samples, a broad suppression of activation of EGFR and downstream signaling molecules was observed in a molecular responder patient, in contrast to a lack of inhibition or increased activation of biomarkers in different pathways in nonresponder patients. Gefitinib sensitivity is correlated with p-AKT and p-STAT3 activation in HNSCC cell lines and tumor specimens. p-AKT and p-STAT3 could serve as potentially useful biomarkers and drug targets for further development of novel therapeutic agents for HNSCC. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Pernas, Francisco G AU - Allen, Clint T AU - Winters, Mary E AU - Yan, Bin AU - Friedman, Jay AU - Dabir, Bhavana AU - Saigal, Kunal AU - Mundinger, Gerhard S AU - Xu, Xiaojiang AU - Morris, John C AU - Calvo, Katherine R AU - Van Waes, Carter AU - Chen, Zhong AD - Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 2361 EP - 2372 VL - 15 IS - 7 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Biomarkers, Tumor KW - NF-kappa B KW - Protein Kinase Inhibitors KW - Quinazolines KW - Epidermal Growth Factor KW - 62229-50-9 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Protein Array Analysis KW - Epidermal Growth Factor -- antagonists & inhibitors KW - Blotting, Western KW - Phosphorylation KW - Cell Survival -- drug effects KW - Humans KW - Clinical Trials, Phase I as Topic KW - Proteomics KW - Biomarkers, Tumor -- analysis KW - Enzyme-Linked Immunosorbent Assay KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - NF-kappa B -- antagonists & inhibitors KW - Carcinoma, Squamous Cell -- enzymology KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Receptor, Epidermal Growth Factor -- metabolism KW - Protein Kinase Inhibitors -- pharmacology KW - Carcinoma, Squamous Cell -- metabolism KW - Head and Neck Neoplasms -- drug therapy KW - Head and Neck Neoplasms -- enzymology KW - Head and Neck Neoplasms -- metabolism KW - Protein Kinase Inhibitors -- therapeutic use KW - Signal Transduction -- drug effects KW - Quinazolines -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Carcinoma, Squamous Cell -- drug therapy KW - Quinazolines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67109562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Proteomic+signatures+of+epidermal+growth+factor+receptor+and+survival+signal+pathways+correspond+to+gefitinib+sensitivity+in+head+and+neck+cancer.&rft.au=Pernas%2C+Francisco+G%3BAllen%2C+Clint+T%3BWinters%2C+Mary+E%3BYan%2C+Bin%3BFriedman%2C+Jay%3BDabir%2C+Bhavana%3BSaigal%2C+Kunal%3BMundinger%2C+Gerhard+S%3BXu%2C+Xiaojiang%3BMorris%2C+John+C%3BCalvo%2C+Katherine+R%3BVan+Waes%2C+Carter%3BChen%2C+Zhong&rft.aulast=Pernas&rft.aufirst=Francisco&rft.date=2009-04-01&rft.volume=15&rft.issue=7&rft.spage=2361&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-08-1011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-22 N1 - Date created - 2009-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-08-1011 ER - TY - JOUR T1 - Comparative study of the prevalence of suicidal behavior and sexual abuse history in delinquent and non-delinquent adolescents. AN - 67107508; 19335395 AB - The present study examined the prevalence of suicidal behavior and sexual abuse history in delinquent and non-delinquent adolescents aged 15-17 years. Results showed that delinquent adolescents, particularly girls, more frequently reported histories of suicidal behavior and sexual abuse than non-delinquent adolescents. JF - Psychiatry and clinical neurosciences AU - Matsumoto, Toshihiko AU - Tsutsumi, Atsuro AU - Izutsu, Takashi AU - Imamura, Fumi AU - Chiba, Yasuhiko AU - Takeshima, Tadashi AD - National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan. tmatsu@ncnp.go.jp Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 238 EP - 240 VL - 63 IS - 2 KW - Index Medicus KW - Self-Injurious Behavior -- psychology KW - Software KW - Prisons KW - Sex Factors KW - Humans KW - Substance-Related Disorders -- complications KW - Self-Injurious Behavior -- epidemiology KW - Child KW - Substance-Related Disorders -- psychology KW - Adolescent KW - Male KW - Female KW - Child Abuse, Sexual -- psychology KW - Juvenile Delinquency -- statistics & numerical data KW - Child Abuse, Sexual -- statistics & numerical data KW - Suicide -- statistics & numerical data KW - Suicide -- psychology KW - Juvenile Delinquency -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67107508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+and+clinical+neurosciences&rft.atitle=Comparative+study+of+the+prevalence+of+suicidal+behavior+and+sexual+abuse+history+in+delinquent+and+non-delinquent+adolescents.&rft.au=Matsumoto%2C+Toshihiko%3BTsutsumi%2C+Atsuro%3BIzutsu%2C+Takashi%3BImamura%2C+Fumi%3BChiba%2C+Yasuhiko%3BTakeshima%2C+Tadashi&rft.aulast=Matsumoto&rft.aufirst=Toshihiko&rft.date=2009-04-01&rft.volume=63&rft.issue=2&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Psychiatry+and+clinical+neurosciences&rft.issn=1440-1819&rft_id=info:doi/10.1111%2Fj.1440-1819.2009.01929.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1440-1819.2009.01929.x ER - TY - JOUR T1 - Subunit- and pathway-specific localization of NMDA receptors and scaffolding proteins at ganglion cell synapses in rat retina. AN - 67102331; 19339621 AB - Retinal ganglion cells (RGCs) receive excitatory glutamatergic input from ON and OFF bipolar cells in distinct sublaminae of the inner plexiform layer (IPL). AMPA and NMDA receptors (AMPARs and NMDARs) mediate excitatory inputs in both synaptic layers, but specific roles for NMDARs at RGC synapses remain unclear. NMDARs comprise NR1 and NR2 subunits and are anchored by membrane-associated guanylate kinases (MAGUKs), but it is unknown whether particular NR2 subunits associate preferentially with particular NR1 splice variants and MAGUKs. Here, we used postembedding immunogold electron microscopy techniques to examine the subsynaptic localization of NMDAR subunits and MAGUKs at ON and OFF synapses onto rat RGCs. We found that the NR2A subunit, the NR1C2' splice variant, and MAGUKs PSD-95 and PSD-93 are localized to the postsynaptic density (PSD), preferentially at OFF synapses, whereas the NR2B subunit, the NR1C2 splice variant, and the MAGUK SAP102 are localized perisynaptically, with NR2B exhibiting a preference for ON synapses. Consistent with these anatomical data, spontaneous EPSCs (sEPSCs) recorded from OFF cells exhibited an NMDAR component that was insensitive to the NR2B antagonist Ro 25-6981. In ON cells, sEPSCs expressed an NMDAR component, partially sensitive to Ro 25-6981, only when glutamate transport was inhibited, indicating perisynaptic expression of NR2B NMDARs. These results provide the first evidence for preferential association of particular NR1 splice variants, NR2 subunits, and MAGUKs at central synapses and suggest that different NMDAR subtypes may play specific roles at functionally distinct synapses in the retinal circuitry. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Zhang, Jun AU - Diamond, Jeffrey S AD - Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-3701, USA. Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 4274 EP - 4286 VL - 29 IS - 13 KW - Excitatory Amino Acid Agents KW - 0 KW - Membrane Proteins KW - NR1 NMDA receptor KW - NR2A NMDA receptor KW - Nerve Tissue Proteins KW - Receptors, N-Methyl-D-Aspartate KW - Cholera Toxin KW - 9012-63-9 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Excitatory Amino Acid Agents -- pharmacology KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Rats KW - Calcium -- metabolism KW - Animals, Newborn KW - Rats, Sprague-Dawley KW - Cerebellum -- cytology KW - Excitatory Postsynaptic Potentials -- drug effects KW - Patch-Clamp Techniques KW - Receptors, N-Methyl-D-Aspartate -- ultrastructure KW - Microscopy, Immunoelectron -- methods KW - In Vitro Techniques KW - Nerve Tissue Proteins -- metabolism KW - Excitatory Postsynaptic Potentials -- physiology KW - Cholera Toxin -- metabolism KW - Retinal Ganglion Cells -- ultrastructure KW - Retina -- cytology KW - Retinal Ganglion Cells -- metabolism KW - Synapses -- ultrastructure KW - Membrane Proteins -- metabolism KW - Retinal Ganglion Cells -- cytology KW - Synapses -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67102331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Subunit-+and+pathway-specific+localization+of+NMDA+receptors+and+scaffolding+proteins+at+ganglion+cell+synapses+in+rat+retina.&rft.au=Zhang%2C+Jun%3BDiamond%2C+Jeffrey+S&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2009-04-01&rft.volume=29&rft.issue=13&rft.spage=4274&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.5602-08.2009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-23 N1 - Date created - 2009-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.5602-08.2009 ER - TY - JOUR T1 - Central role of c-Myc during malignant conversion in human hepatocarcinogenesis. AN - 67098245; 19276364 AB - Hepatocarcinogenesis is a multistage process in which precursor lesions progress into early hepatocellular carcinomas (eHCC) by sequential accumulation of multiple genetic and epigenetic alterations. To decode the molecular events during early stages of liver carcinogenesis, we performed gene expression profiling on cirrhotic (regenerative) and dysplastic nodules (DN), as well as eHCC. Although considerable heterogeneity was observed at the regenerative and dysplastic stages, overall, 460 differentially expressed genes were detected between DN and eHCC. Functional analysis of the significant gene set identified the MYC oncogene as a plausible driver gene for malignant conversion of the DNs. In addition, gene set enrichment analysis revealed global activation of the MYC up-regulated gene set in eHCC versus dysplasia. Presence of the MYC signature significantly correlated with increased expression of CSN5, as well as with higher overall transcription rate of genes located in the 8q chromosome region. Furthermore, a classifier constructed from MYC target genes could robustly discriminate eHCC from high-grade and low-grade DNs. In conclusion, our study identified unique expression patterns associated with the transition of high-grade DNs into eHCC and showed that activation of the MYC transcription signature is strongly associated with the malignant conversion of preneoplastic liver lesions. JF - Cancer research AU - Kaposi-Novak, Pal AU - Libbrecht, Louis AU - Woo, Hyun Goo AU - Lee, Yun-Han AU - Sears, Nathaniel C AU - Coulouarn, Cedric AU - Conner, Elizabeth A AU - Factor, Valentina M AU - Roskams, Tania AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, Maryland 20892, USA. Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 2775 EP - 2782 VL - 69 IS - 7 KW - MYC protein, human KW - 0 KW - Proto-Oncogene Proteins c-myc KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Liver Cirrhosis -- pathology KW - Gene Expression Profiling KW - Precancerous Conditions -- genetics KW - Neoplasm Staging KW - Humans KW - Liver Cirrhosis -- metabolism KW - Disease Progression KW - Precancerous Conditions -- metabolism KW - Liver Cirrhosis -- genetics KW - Precancerous Conditions -- pathology KW - Proto-Oncogene Proteins c-myc -- biosynthesis KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Cell Transformation, Neoplastic -- pathology KW - Genes, myc KW - Cell Transformation, Neoplastic -- metabolism KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - Proto-Oncogene Proteins c-myc -- genetics KW - Cell Transformation, Neoplastic -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67098245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Central+role+of+c-Myc+during+malignant+conversion+in+human+hepatocarcinogenesis.&rft.au=Kaposi-Novak%2C+Pal%3BLibbrecht%2C+Louis%3BWoo%2C+Hyun+Goo%3BLee%2C+Yun-Han%3BSears%2C+Nathaniel+C%3BCoulouarn%2C+Cedric%3BConner%2C+Elizabeth+A%3BFactor%2C+Valentina+M%3BRoskams%2C+Tania%3BThorgeirsson%2C+Snorri+S&rft.aulast=Kaposi-Novak&rft.aufirst=Pal&rft.date=2009-04-01&rft.volume=69&rft.issue=7&rft.spage=2775&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-3357 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-02 N1 - Date created - 2009-04-02 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE12443; GEO N1 - SuppNotes - Cited By: Semin Liver Dis. 2005;25(2):162-70 [15918145] Nature. 2005 Aug 11;436(7052):807-11 [16094360] Hepatology. 2005 Oct;42(4):809-18 [16175600] Carcinogenesis. 2005 Dec;26(12):2050-7 [16000397] Nature. 2006 Jan 19;439(7074):353-7 [16273092] Nat Genet. 2006 Apr;38(4):421-30 [16518402] Nat Med. 2006 Apr;12(4):410-6 [16532004] Gastroenterology. 2006 Apr;130(4):1117-28 [16618406] Curr Top Microbiol Immunol. 2006;302:1-32 [16620023] J Clin Invest. 2006 Jun;116(6):1582-95 [16710476] Oncogene. 2006 Jun 26;25(27):3848-56 [16799626] Semin Cancer Biol. 2006 Aug;16(4):313-7 [16935001] Hepatology. 2006 Oct;44(4):1003-11 [17006931] Gastroenterology. 2006 Oct;131(4):1262-70 [17030195] Semin Liver Dis. 2007 Feb;27(1):55-76 [17295177] Hepatology. 2007 Mar;45(3):725-34 [17326147] Hepatology. 2007 Apr;45(4):938-47 [17393520] Nature. 2007 Apr 5;446(7136):676-9 [17377531] Nat Rev Cancer. 2008 Jan;8(1):51-6 [18046334] J Pathol. 2000 Oct;192(2):207-15 [11004697] Nucleic Acids Res. 2002 May 1;30(9):e36 [11972351] Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6274-9 [11983916] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Digestion. 2002;66(3):131-44 [12481159] Annu Rev Cell Dev Biol. 2003;19:261-86 [14570571] Urology. 2003 Nov;62(5 Suppl 1):55-62 [14607218] Nature. 2004 Oct 28;431(7012):1112-7 [15475948] Cell. 1990 Jun 1;61(5):759-67 [2188735] J Hepatol. 1992 Mar;14(2-3):342-6 [1323601] Hepatology. 1995 Sep;22(3):983-93 [7657307] Carcinogenesis. 1997 Jan;18(1):59-81 [9054591] Science. 1998 Sep 4;281(5382):1509-12 [9727977] Mol Cell. 1999 Feb;3(2):169-79 [10078200] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] Nat Genet. 2005 Jan;37(1):48-55 [15608639] Hum Pathol. 2004 Nov;35(11):1324-31 [15668888] Liver Int. 2005 Feb;25(1):70-6 [15698401] Gastroenterology. 2005 May;128(5):1369-80 [15887118] Semin Liver Dis. 2005;25(2):133-42 [15918142] Erratum In: Cancer Res. 2009 Apr 15;69(8):3721 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-3357 ER - TY - JOUR T1 - Infection in pregnancy and cerebral palsy. AN - 67091842; 19335562 JF - Developmental medicine and child neurology AU - Nelson, Karin B AD - National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 253 EP - 254 VL - 51 IS - 4 KW - Anti-Bacterial Agents KW - 0 KW - Index Medicus KW - Anti-Bacterial Agents -- therapeutic use KW - Risk Factors KW - Humans KW - Anti-Bacterial Agents -- adverse effects KW - Male KW - Female KW - Pregnancy KW - Urinary Tract Infections -- drug therapy KW - Urinary Tract Infections -- epidemiology KW - Urinary Tract Infections -- complications KW - Pregnancy Complications, Infectious -- epidemiology KW - Pregnancy Complications, Infectious -- drug therapy KW - Cerebral Palsy -- epidemiology KW - Cerebral Palsy -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67091842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+medicine+and+child+neurology&rft.atitle=Infection+in+pregnancy+and+cerebral+palsy.&rft.au=Nelson%2C+Karin+B&rft.aulast=Nelson&rft.aufirst=Karin&rft.date=2009-04-01&rft.volume=51&rft.issue=4&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Developmental+medicine+and+child+neurology&rft.issn=1469-8749&rft_id=info:doi/10.1111%2Fj.1469-8749.2008.03256.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-04 N1 - Date created - 2009-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Dev Med Child Neurol. 2009 Apr;51(4):282-8 [19191825] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1469-8749.2008.03256.x ER - TY - JOUR T1 - A liquid chromatography tandem mass spectrometry method for the simultaneous quantification of 20 drugs of abuse and metabolites in human meconium. AN - 67086061; 19241063 AB - A method for the simultaneous quantification of 20 cocaine, amphetamine, opiate, and nicotine analytes in meconium, the first neonatal feces, by liquid chromatography tandem mass spectrometry was developed and validated. Specimen preparation included methanol homogenization and solid phase extraction. Two injections were required to achieve sufficient sensitivity and linear dynamic range. Linearity ranged from 0.5-25 up to 500 ng/g (250 ng/g p-hydroxymethamphetamine), and correlation coefficients were >0.996. Imprecision was 46.7% at three concentrations across the linear range. Despite significant matrix effects of -305.7-40.7%, effects were similar for native and deuterated analytes. No carryover, endogenous or exogenous interferences were observed, with analyte stability at room temperature, 4 degrees C, and -20 degrees C and on the autosampler >70%, except for 6-acetylmorphine, hydrocodone, oxycodone, and morphine. Method applicability was demonstrated by analyzing meconium from drug-exposed neonates. JF - Analytical and bioanalytical chemistry AU - Gray, Teresa R AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD 21224, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 1977 EP - 1990 VL - 393 IS - 8 KW - Narcotics KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Sensitivity and Specificity KW - Humans KW - Substance-Related Disorders KW - Infant, Newborn KW - Chromatography, Liquid KW - Tandem Mass Spectrometry KW - Feces -- chemistry KW - Cocaine -- analysis KW - Meconium -- metabolism KW - Meconium -- chemistry KW - Amphetamine -- analysis KW - Substance Abuse Detection -- methods KW - Narcotics -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67086061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+bioanalytical+chemistry&rft.atitle=A+liquid+chromatography+tandem+mass+spectrometry+method+for+the+simultaneous+quantification+of+20+drugs+of+abuse+and+metabolites+in+human+meconium.&rft.au=Gray%2C+Teresa+R%3BShakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Gray&rft.aufirst=Teresa&rft.date=2009-04-01&rft.volume=393&rft.issue=8&rft.spage=1977&rft.isbn=&rft.btitle=&rft.title=Analytical+and+bioanalytical+chemistry&rft.issn=1618-2650&rft_id=info:doi/10.1007%2Fs00216-009-2680-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-23 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Forensic Sci Int. 1999 Jun 28;102(2-3):167-71 [10464932] Clin Chem. 2004 Dec;50(12):2323-30 [15472033] Anal Bioanal Chem. 2007 Aug;388(7):1455-65 [17370066] J Appl Toxicol. 2007 Sep-Oct;27(5):464-71 [17299832] Obstet Gynecol Surv. 2007 Nov;62(11):749-57 [17925048] Ther Drug Monit. 2007 Dec;29(6):711-34 [18043469] Anal Chem. 2008 Jan 1;80(1):246-52 [18044957] Drug Alcohol Rev. 2008 Mar;27(2):197-9 [18264882] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):107-14 [18243821] Clin Infect Dis. 2008 Mar 15;46(6):953-5; author reply 955-6 [18288906] Neuro Endocrinol Lett. 2008 Feb;29(1):80-6 [18283247] Drug Alcohol Depend. 2008 Jul 1;96(1-2):69-78 [18355989] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 15;867(2):194-204 [18424195] Drug Alcohol Rev. 2008 Jul;27(4):449-50 [18584400] Clin Pharmacol Ther. 2008 Nov;84(5):604-12 [18701886] Clin Chem. 2008 Dec;54(12):2018-27 [18845770] Ther Drug Monit. 2009 Feb;31(1):70-5 [19125148] J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jan 25;814(2):369-73 [15639461] J Anal Toxicol. 2005 Jan-Feb;29(1):54-7 [15808014] J Perinatol. 2005 Jun;25(6):368-74 [15703775] Drug Alcohol Depend. 2005 Jul;79(1):1-10 [15943939] Forensic Sci Int. 2005 Oct 4;153(1):59-65 [15923097] East Mediterr Health J. 2004 Jan-Mar;10(1-2):96-105 [16201714] Addiction. 2006 Feb;101(2):275-81 [16445556] Drug Alcohol Depend. 2006 May 20;82(3):250-7 [16257138] Matern Child Health J. 2006 May;10(3):293-302 [16395620] Clin Infect Dis. 2006 Dec 15;43 Suppl 4:S197-215 [17109307] Acta Obstet Gynecol Scand. 2007;86(2):185-90 [17364281] J Anal Toxicol. 2007 Jan-Feb;31(1):1-14 [17389078] Subst Use Misuse. 2007;42(6):1027-8 [17613961] Anal Chem. 2000 Feb 15;72(4):764-71 [10701261] Matern Child Health J. 1999 Sep;3(3):161-6 [10746755] J Anal Toxicol. 2001 Jan-Feb;25(1):40-4 [11215999] Pediatrics. 2001 Feb;107(2):309-17 [11158464] J Pediatr. 2001 Mar;138(3):344-8 [11241040] J Anal Toxicol. 2001 Mar;25(2):93-8 [11300513] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Sep 5;794(2):281-92 [12954379] Anal Chem. 2003 Jul 1;75(13):3019-30 [12964746] Clin Chem. 1981 Jan;27(1):202 [7449114] Clin Chem. 1984 Feb;30(2):290-2 [6692538] J Anal Toxicol. 1995 Oct;19(6):514-8 [8926748] J Anal Toxicol. 1996 Oct;20(6):453-62 [8889682] J Anal Toxicol. 1997 Mar-Apr;21(2):154-9 [9083834] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00216-009-2680-5 ER - TY - JOUR T1 - Determinants of exposure to metalworking fluid aerosols: a literature review and analysis of reported measurements. AN - 67085360; 19329796 AB - An extensive literature review of published metalworking fluid (MWF) aerosol measurement data was conducted to identify the major determinants that may affect exposure to aerosol fractions (total or inhalable, thoracic and respirable) and mass median diameters (MMDs). The identification of determinants was conducted through published studies and analysis of published measurement levels. For the latter, weighted arithmetic means (WAMs) by number of measurements were calculated and compared using analysis of variance and t-tests. The literature review found that the major factors affecting aerosol exposure levels were, primarily, decade, type of industry, operation and fluid and engineering control measures. Our analysis of total aerosol levels found a significant decline in measured levels from an average of 5.36 mg m(-3) prior to the 1970s and 2.52 mg m(-3) in the 1970s to 1.21 mg m(-3) in the 1980s, 0.50 mg m(-3) in the 1990s and 0.55 mg m(-3) in the 2000s. Significant declines from the 1990s to the 2000s also were found in thoracic fraction levels (0.48 versus 0.40 mg m(-3)), but not for the respirable fraction. The WAMs for the auto (1.47 mg m(-3)) and auto parts manufacturing industry (1.83 mg m(-3)) were significantly higher than that for small-job machine shops (0.68 mg m(-3)). In addition, a significant difference in the thoracic WAM was found between the automotive industry (0.46 mg m(-3)) and small-job machine shops (0.32 mg m(-3)). Operation type, in particular, grinding, was a significant factor affecting the total aerosol fraction [grinding operations (1.75 mg m(-3)) versus other machining (0.95 mg m(-3))], but the levels associated with these operations were not statistically different for either the thoracic or the respirable fractions. Across all decades, the total aerosol fraction for straight oils (1.49 mg m(-3)) was higher than for other fluid types (soluble = 1.08 mg m(-3), synthetic = 0.52 mg m(-3) and semisynthetic = 0.50 mg m(-3)). Fluid type was also found to be partly associated with differences in the respirable fraction level. We found that the total aerosols were measured by a variety of sampling media, devices and analytical methods. This diversity of approaches makes interpretation of the study results difficult. In conclusion, both the literature review and the measurement data analyzed found that decade and type of industry, operation and fluid were important determinants of total aerosol exposure. Industry type and fluid type were associated with differences in exposure to the thoracic and respirable fraction levels, respectively. JF - The Annals of occupational hygiene AU - Park, Donguk AU - Stewart, Patrica A AU - Coble, Joseph B AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA. pdw545@knou.ac.kr Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 271 EP - 288 VL - 53 IS - 3 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Index Medicus KW - Industrial Oils -- analysis KW - Particle Size KW - Humans KW - Risk Assessment -- methods KW - Environmental Monitoring -- methods KW - Aerosols -- analysis KW - Air Pollutants, Occupational -- analysis KW - Occupational Exposure -- analysis KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67085360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Determinants+of+exposure+to+metalworking+fluid+aerosols%3A+a+literature+review+and+analysis+of+reported+measurements.&rft.au=Park%2C+Donguk%3BStewart%2C+Patrica+A%3BCoble%2C+Joseph+B&rft.aulast=Park&rft.aufirst=Donguk&rft.date=2009-04-01&rft.volume=53&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmep005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-14 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Occup Environ Med. 2001 May;43(5):483-93 [11382184] Appl Occup Environ Hyg. 2000 Aug;15(8):618-28 [10957817] AIHAJ. 2001 May-Jun;62(3):342-8 [11434440] AIHAJ. 2001 May-Jun;62(3):356-70 [11434442] AIHAJ. 2001 May-Jun;62(3):379-82 [11434444] Scand J Work Environ Health. 2001 Aug;27(4):240-9 [11560338] Ann Occup Hyg. 2003 Jan;47(1):17-30 [12505903] Appl Occup Environ Hyg. 2003 Nov;18(11):838-41 [14555436] Appl Occup Environ Hyg. 2003 Nov;18(11):842-54 [14555437] Occup Environ Med. 2004 May;61(5):426-31 [15090663] Ann Occup Hyg. 2004 Jul;48(5):383-91 [15240341] J Occup Med. 1970 Jul;12(7):253-61 [5451053] Am J Ind Med. 1988;13(5):569-80 [3376946] J Occup Med. 1988 Sep;30(9):706-14 [3183787] J Occup Environ Hyg. 2007 Apr;4(4):288-300 [17365501] Occup Environ Med. 2007 Apr;64(4):244-9 [16912088] J Occup Environ Hyg. 2008 Jan;5(1):36-47 [18041643] Ann Occup Hyg. 2008 Oct;52(7):597-605 [18664515] J Occup Environ Hyg. 2009 Sep;6(9):530-41 [19544177] Am J Ind Med. 1988;14(4):465-77 [3189359] Scand J Work Environ Health. 1992 Dec;18(6):351-60 [1485160] Am Ind Hyg Assoc J. 1994 Jan;55(1):20-9 [8116525] Am J Ind Med. 1994 Aug;26(2):185-202 [7977395] Am J Ind Med. 1994 Nov;26(5):621-34 [7832210] Am Ind Hyg Assoc J. 1996 Dec;57(12):1137-41 [8976588] Am Ind Hyg Assoc J. 1996 Dec;57(12):1149-53 [8976589] Am Ind Hyg Assoc J. 1996 Dec;57(12):1154-62 [8976590] Am Ind Hyg Assoc J. 1996 Dec;57(12):1173-8 [8976592] Am J Ind Med. 1997 May;31(5):525-33 [9099353] Am J Ind Med. 1997 Jun;31(6):671-7 [9131220] Am J Ind Med. 1997 Sep;32(3):240-7 [9219653] Am J Ind Med. 1997 Nov;32(5):450-9 [9327068] Am J Ind Med. 1998 Mar;33(3):282-92 [9481427] Am J Ind Med. 1998 Jul;34(1):36-48 [9617386] Scand J Work Environ Health. 1998 Apr;24(2):125-9 [9630060] Am J Respir Crit Care Med. 1999 Jan;159(1):87-93 [9872823] Am J Ind Med. 2005 Feb;47(2):153-60 [15662639] J Occup Environ Hyg. 2005 Apr;2(4):219-26 [15788383] Scand J Work Environ Health. 2005 Jun;31(3):205-11 [15999572] Occup Environ Med. 2005 Sep;62(9):633-41 [16109820] Epidemiology. 2005 Sep;16(5):664-71 [16135943] J Occup Environ Hyg. 2005 Dec;2(12):609-25 [16282165] Ann Occup Hyg. 2006 Apr;50(3):249-57 [16361396] Appl Occup Environ Hyg. 2000 Apr;15(4):370-9 [10750281] AIHAJ. 2000 Mar-Apr;61(2):275-81 [10782200] Appl Occup Environ Hyg. 2000 Jun;15(6):492-502 [10853290] Am J Ind Med. 2001 Jun;39(6):616-28 [11385646] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mep005 ER - TY - JOUR T1 - Randomized, controlled trial of prednisone, cyclophosphamide, and cyclosporine in lupus membranous nephropathy. AN - 67080714; 19297556 AB - Patients with lupus membranous nephropathy (LMN) are at substantial long-term risk for morbidity and mortality associated with protracted nephrotic syndrome, including ESRD. The optimal treatment for this condition is controversial. Forty-two patients with LMN participated in a randomized, controlled trial to compare adjunctive immunosuppressive drugs with prednisone alone. Adjunctive regimens included either cyclosporine (CsA) for 11 mo or alternate-month intravenous pulse cyclophosphamide (IVCY) for six doses; the control group received alternate-day prednisone alone. Median proteinuria was 5.4 g/d (range 2.7 to 15.4 g/d). We assessed the primary outcome, time to remission of proteinuria during the 12-mo protocol, by univariate survival analysis. At 1 yr, the cumulative probability of remission was 27% with prednisone, 60% with IVCY, and 83% with CsA. Although both IVCY and CsA were more effective than prednisone in inducing remissions of proteinuria, relapse of nephrotic syndrome occurred significantly more often after completion of CsA than after IVCY. By multivariate survival analysis, treatment with prednisone and high-grade proteinuria (>5 g/d) but not race or ethnicity were independently associated with a decreased probability of remission. Adverse effects during the 12-mo protocol included insulin-requiring diabetes (one with prednisone and two with CsA), pneumonia (one with prednisone and two with CsA), and localized herpes zoster (two with IVCY). In conclusion, regimens containing CsA or IVCY are each more effective than prednisone alone in inducing remission of proteinuria among patients with LMN. JF - Journal of the American Society of Nephrology : JASN AU - Austin, Howard A AU - Illei, Gabor G AU - Braun, Michelle J AU - Balow, James E AD - Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, CRC 5-2551, Bethesda, Maryland 20892-1455, USA. howarda@bdg10.niddk.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 901 EP - 911 VL - 20 IS - 4 KW - Immunosuppressive Agents KW - 0 KW - Serum Albumin KW - Cyclosporine KW - 83HN0GTJ6D KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Young Adult KW - Serum Albumin -- metabolism KW - Age of Onset KW - Humans KW - Prognosis KW - Proteinuria -- drug therapy KW - Adult KW - Hematocrit KW - Middle Aged KW - Adolescent KW - Serum Albumin -- drug effects KW - Female KW - Male KW - Lupus Nephritis -- drug therapy KW - Cyclophosphamide -- therapeutic use KW - Prednisone -- therapeutic use KW - Cyclosporine -- therapeutic use KW - Lupus Nephritis -- immunology KW - Immunosuppressive Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67080714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=Randomized%2C+controlled+trial+of+prednisone%2C+cyclophosphamide%2C+and+cyclosporine+in+lupus+membranous+nephropathy.&rft.au=Austin%2C+Howard+A%3BIllei%2C+Gabor+G%3BBraun%2C+Michelle+J%3BBalow%2C+James+E&rft.aulast=Austin&rft.aufirst=Howard&rft.date=2009-04-01&rft.volume=20&rft.issue=4&rft.spage=901&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=1533-3450&rft_id=info:doi/10.1681%2FASN.2008060665 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-22 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lupus. 2000;9(4):241-51 [10866094] N Engl J Med. 1989 Jan 26;320(4):210-5 [2643046] Kidney Int. 2001 Apr;59(4):1484-90 [11260412] Q J Med. 1990 Feb;74(274):133-56 [2189149] Am J Kidney Dis. 1992 May;19(5):473-9 [1585937] Kidney Int. 1992 Oct;42(4):960-6 [1453588] Am J Ophthalmol. 1993 May 15;115(5):583-91 [8488909] Clin Nephrol. 1993 Apr;39(4):175-82 [8491046] Kidney Int. 1993 Sep;44(3):638-42 [8231039] Kidney Int. 1994 Feb;45(2):544-50 [8164443] Am J Kidney Dis. 1994 Aug;24(2):159-71 [8048420] Clin Nephrol. 1994 Sep;42(3):147-54 [7994932] Kidney Int. 1995 Apr;47(4):1130-5 [7783410] Lupus. 1995 Apr;4(2):109-15 [7795613] Nephrol Dial Transplant. 1995;10(9):1620-8 [8559480] J Am Soc Nephrol. 1996 Feb;7(2):299-305 [8785400] Kidney Int. 1997 Mar;51(3):901-7 [9067928] Kidney Int. 1997 Apr;51(4):1188-95 [9083285] Arthritis Rheum. 1997 Sep;40(9):1725 [9324032] Am J Kidney Dis. 1998 Apr;31(4):681-6 [9531186] Arthritis Rheum. 1998 Jul;41(7):1173-80 [9663472] QJM. 1999 Apr;92(4):211-8 [10396609] Lupus. 1999;8(7):545-51 [10483033] Kidney Int. 2004 Dec;66(6):2411-5 [15569333] Rheumatology (Oxford). 2005 Oct;44(10):1317-21 [16049051] Kidney Int. 2006 May;69(10):1846-51 [16598205] Rheumatol Int. 2006 Oct;26(12):1078-83 [16736162] J Am Soc Nephrol. 2007 Jan;18(1):244-54 [17167111] Kidney Int. 2007 Dec;72(12):1429-47 [17898700] Lupus. 2008 Jan;17(1):40-5 [18089682] Presse Med. 2008 Apr;37(4 Pt 1):559-63 [18155876] QJM. 2001 Jan;94(1):19-26 [11161132] Arthritis Rheum. 2001 Dec;44(12):2797-806 [11762940] Lupus. 2002;11(2):95-101 [11958584] Lupus. 2002;11(3):152-60 [12004788] Am J Med. 2002 Jun 15;112(9):726-9 [12079714] Nephrol Dial Transplant. 2002 Oct;17(10):1771-8 [12270983] Nephrol Dial Transplant. 2003 Oct;18(10):2039-46 [13679478] Chin Med J (Engl). 2003 Dec;116(12):1827-30 [14687467] J Am Soc Nephrol. 2004 Feb;15(2):241-50 [14747370] Am J Kidney Dis. 2004 Feb;43(2):269-76 [14750092] Rheumatology (Oxford). 2004 Mar;43(3):377-80 [14963204] Kidney Int. 2004 Sep;66(3):1199-205 [15327418] Medicine (Baltimore). 1971 Mar;50(2):85-95 [4109481] Am J Med. 1976 Feb;60(2):221-5 [1251849] Lupus. 2001;10(4):295-8 [11341107] Medicine (Baltimore). 1977 Nov;56(6):527-36 [916891] N Engl J Med. 1978 Nov 23;299(21):1151-5 [309095] Arthritis Rheum. 1979 Jul;22(7):764-9 [454503] Ann Intern Med. 1982 Jun;96(6 Pt 1):728-36 [7046543] Arthritis Rheum. 1982 Nov;25(11):1271-7 [7138600] Kidney Int. 1984 Apr;25(4):689-95 [6482173] Adv Nephrol Necker Hosp. 1985;14:347-64 [3919538] N Engl J Med. 1986 May 15;314(20):1293-8 [3702930] Am J Med. 1987 Nov;83(5):877-85 [3674094] Comment In: J Am Soc Nephrol. 2009 Apr;20(4):690-1 [19279123] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1681/ASN.2008060665 ER - TY - JOUR T1 - An extensive genetic program occurring during postnatal growth in multiple tissues. AN - 67060794; 19036884 AB - Mammalian somatic growth is rapid in early postnatal life but then slows and eventually ceases in multiple tissues. We hypothesized that there exists a postnatal gene expression program that is common to multiple tissues and is responsible for this coordinate growth deceleration. Consistent with this hypothesis, microarray analysis identified more than 1600 genes that were regulated with age (1 vs. 4 wk) coordinately in kidney, lung, and heart of male mice, including many genes that regulate proliferation. As examples, we focused on three growth-promoting genes, Igf2, Mest, and Peg3, that were markedly down-regulated with age. In situ hybridization revealed that expression occurred in organ-specific parenchymal cells and suggested that the decreasing expression with age was due primarily to decreased expression per cell rather than a decreased number of expressing cells. The declining expression of these genes was slowed during hypothyroidism and growth inhibition (induced by propylthiouracil at 0-5 wk of age) in male rats, suggesting that the normal decline in expression is driven by growth rather than by age per se. We conclude that there exists an extensive genetic program occurring during postnatal life. Many of the involved genes are regulated coordinately in multiple organs, including many genes that regulate cell proliferation. At least some of these are themselves apparently regulated by growth, suggesting that, in the embryo, a gene expression pattern is established that allows for rapid somatic growth of multiple tissues, but then, during postnatal life, this growth leads to negative-feedback changes in gene expression that in turn slow and eventually halt somatic growth, thus imposing a fundamental limit on adult body size. JF - Endocrinology AU - Finkielstain, Gabriela P AU - Forcinito, Patricia AU - Lui, Julian C K AU - Barnes, Kevin M AU - Marino, Rose AU - Makaroun, Sami AU - Nguyen, Vina AU - Lazarus, Jacob E AU - Nilsson, Ola AU - Baron, Jeffrey AD - Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1103, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 1791 EP - 1800 VL - 150 IS - 4 KW - IGF2 protein, mouse KW - 0 KW - Igf2bp3 protein, mouse KW - Kruppel-Like Transcription Factors KW - Peg3 protein, mouse KW - Proteins KW - RNA, Messenger KW - RNA-Binding Proteins KW - mesoderm specific transcript protein KW - Insulin-Like Growth Factor II KW - 67763-97-7 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - RNA-Binding Proteins -- genetics KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Insulin-Like Growth Factor II -- genetics KW - Mice KW - Computational Biology KW - Hypothyroidism -- chemically induced KW - Hypothyroidism -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Proteins -- genetics KW - Rats KW - Rats, Sprague-Dawley KW - In Situ Hybridization KW - Mice, Inbred C57BL KW - Kruppel-Like Transcription Factors -- genetics KW - Male KW - Gene Expression Regulation, Developmental -- physiology KW - Gene Expression Regulation, Developmental -- genetics KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67060794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=An+extensive+genetic+program+occurring+during+postnatal+growth+in+multiple+tissues.&rft.au=Finkielstain%2C+Gabriela+P%3BForcinito%2C+Patricia%3BLui%2C+Julian+C+K%3BBarnes%2C+Kevin+M%3BMarino%2C+Rose%3BMakaroun%2C+Sami%3BNguyen%2C+Vina%3BLazarus%2C+Jacob+E%3BNilsson%2C+Ola%3BBaron%2C+Jeffrey&rft.aulast=Finkielstain&rft.aufirst=Gabriela&rft.date=2009-04-01&rft.volume=150&rft.issue=4&rft.spage=1791&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2008-0868 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-14 N1 - Date created - 2009-03-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genesis. 2004 May;39(1):65-72 [15124229] Pediatr Res. 2008 Sep;64(3):240-5 [18535488] Trends Endocrinol Metab. 2004 Oct;15(8):370-4 [15380808] Dev Biol. 1965 Dec;12(3):451-66 [5884354] Am Rev Respir Dis. 1975 Jun;111(6):803-44 [1094872] Acta Endocrinol (Copenh). 1978 Dec;89(4):780-8 [716781] Biol Reprod. 1978 Nov;19(4):807-16 [570431] Life Sci. 1984 Apr 9;34(15):1487-96 [6708742] Nature. 1985 Sep 19-25;317(6034):260-2 [2995818] Biol Reprod. 1986 Mar;34(2):322-6 [3955146] J Biol Chem. 1986 Oct 5;261(28):13144-50 [3759952] Development. 1988 Jul;103(3):497-506 [3246220] J Pharm Pharmacol. 1989 Jul;41(7):439-44 [2570847] Nature. 1990 May 3;345(6270):78-80 [2330056] Cell. 1991 Feb 22;64(4):849-59 [1997210] Endocrinology. 1991 Dec;129(6):3281-8 [1659527] Nucleic Acids Res. 1993 Apr 25;21(8):2009 [8493110] Nature. 1996 Apr 25;380(6576):711-4 [8614465] Eur J Pediatr. 1996 May;155(5):362-7 [8741031] Am J Physiol. 1996 Aug;271(2 Pt 1):L332-9 [8770073] Physiol Rev. 1996 Oct;76(4):1005-26 [8874492] J Mol Cell Cardiol. 1996 Aug;28(8):1737-46 [8877783] Am J Physiol. 1996 Nov;271(5 Pt 2):H2183-9 [8945939] Endocr Rev. 1997 Oct;18(5):646-61 [9331546] Nature. 1997 Oct 23;389(6653):809-15 [9349812] Hum Mol Genet. 1997 Oct;6(11):1907-15 [9302270] Semin Immunol. 1998 Apr;10(2):127-32 [9618758] Brain Res Mol Brain Res. 2000 Jun 23;79(1-2):180-91 [10925158] Dev Biol. 2001 Jan 1;229(1):141-62 [11133160] J Bone Miner Res. 2000 Dec;15(12):2402-12 [11127205] Toxicol Sci. 2001 Apr;60(2):285-95 [11248141] Nat Rev Mol Cell Biol. 2001 Jan;2(1):48-54 [11413465] J Histochem Cytochem. 2002 Apr;50(4):541-8 [11897807] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4397-402 [11917104] Am J Physiol Renal Physiol. 2002 May;282(5):F953-65 [11934706] J Biol Chem. 2002 Jun 21;277(25):23000-7 [11943780] J Clin Endocrinol Metab. 1998 Sep;83(9):3252-7 [9745438] Nat Genet. 1998 Oct;20(2):163-9 [9771709] Circ Res. 1998 Nov 16;83(10):986-94 [9815146] Science. 1999 Apr 9;284(5412):330-3 [10195900] J Pediatr Orthop. 1999 May-Jun;19(3):398-403 [10344328] Endocrinology. 1999 Jul;140(7):3391-4 [10385438] Nephron Exp Nephrol. 2004;98(4):e109-13 [15627793] Endocrinology. 2005 Mar;146(3):1012-7 [15604211] Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2814-9 [15710898] J Mol Endocrinol. 2005 Apr;34(2):489-503 [15821112] Horm Res. 2005;63(3):125-8 [15795509] J Biol Chem. 2005 May 6;280(18):18517-24 [15753088] J Endocrinol. 2005 Jul;186(1):241-9 [16002553] FASEB J. 2005 Aug;19(10):1302-4 [15928196] Transpl Immunol. 2005 Oct;15(1):1-8 [16223667] Nat Rev Neurosci. 2005 Dec;6(12):945-54 [16340955] Nephron Physiol. 2006;102(3-4):p81-91 [16340241] Endocrinology. 2006 Nov;147(11):5132-8 [16873534] Dev Cell. 2006 Nov;11(5):711-22 [17084362] Pituitary. 2007;10(2):151-7 [17429593] J Endocrinol. 2007 Jul;194(1):31-40 [17592018] Endocrinology. 2008 Apr;149(4):1820-8 [18174286] Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R189-96 [18448610] Birth Defects Res B Dev Reprod Toxicol. 2004 Jun;71(3):185-90 [15282739] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2008-0868 ER - TY - JOUR T1 - Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow. AN - 67052302; 19299733 AB - IL-27 exerts antitumor activity in murine orthotopic neuroblastoma, but only partial antitumor effect in disseminated disease. This study demonstrates that combined treatment with IL-2 and IL-27 induces potent antitumor activity in disseminated neuroblastoma metastasis. Complete durable tumor regression was achieved in 90% of mice bearing metastatic TBJ-IL-27 tumors treated with IL-2 compared with only 40% of mice bearing TBJ-IL-27 tumors alone and 0% of mice bearing TBJ-FLAG tumors with or without IL-2 treatment. Comparable antitumor effects were achieved by IL-27 protein produced upon hydrodynamic IL-27 plasmid DNA delivery when combined with IL-2. Although delivery of IL-27 alone, or in combination with IL-2, mediated pronounced regression of neuroblastoma metastases in the liver, combined delivery of IL-27 and IL-2 was far more effective than IL-27 alone against bone marrow metastases. Combined exposure to IL-27 produced by tumor and IL-2 synergistically enhances the generation of tumor-specific CTL reactivity. Potentiation of CTL reactivity by IL-27 occurs via mechanisms that appear to be engaged during both the initial sensitization and effector phase. Potent immunologic memory responses are generated in mice cured of their disseminated disease by combined delivery of IL-27 and IL-2, and depletion of CD8(+) ablates the antitumor efficacy of this combination. Moreover, IL-27 delivery can inhibit the expansion of CD4(+)CD25(+)Foxp3(+) regulatory and IL-17-expressing CD4(+) cells that are otherwise observed among tumor-infiltrating lymphocytes from mice treated with IL-2. These studies demonstrate that IL-27 and IL-2 synergistically induce complete tumor regression and long-term survival in mice bearing widely metastatic neuroblastoma tumors. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Salcedo, Rosalba AU - Hixon, Julie A AU - Stauffer, Jimmy K AU - Jalah, Rashmi AU - Brooks, Alan D AU - Khan, Tahira AU - Dai, Ren-Ming AU - Scheetz, Loretta AU - Lincoln, Erin AU - Back, Timothy C AU - Powell, Douglas AU - Hurwitz, Arthur A AU - Sayers, Thomas J AU - Kastelein, Robert AU - Pavlakis, George N AU - Felber, Barbara K AU - Trinchieri, Giorgio AU - Wigginton, Jon M AD - Science Applications International Corporation, National Cancer Institute-Frederick, MD 21702, USA. lmirosi@ncifcrf.gov Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 4328 EP - 4338 VL - 182 IS - 7 KW - Il27 protein, mouse KW - 0 KW - Interleukin-2 KW - Interleukins KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Bone Marrow Neoplasms -- secondary KW - Animals KW - Lymphocytes, Tumor-Infiltrating -- immunology KW - Liver Neoplasms -- drug therapy KW - Bone Marrow Neoplasms -- drug therapy KW - Mice KW - Interferon-gamma -- immunology KW - Flow Cytometry KW - Liver Neoplasms -- secondary KW - Drug Synergism KW - Male KW - Interleukin-2 -- administration & dosage KW - T-Lymphocytes, Cytotoxic -- immunology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- immunology KW - Lymphocyte Activation -- drug effects KW - Neuroblastoma -- secondary KW - Interleukins -- administration & dosage KW - Neuroblastoma -- immunology KW - Neuroblastoma -- drug therapy KW - Lymphocyte Activation -- immunology KW - Interleukin-2 -- immunology KW - Interleukins -- immunology KW - T-Lymphocytes, Cytotoxic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67052302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Immunologic+and+therapeutic+synergy+of+IL-27+and+IL-2%3A+enhancement+of+T+cell+sensitization%2C+tumor-specific+CTL+reactivity+and+complete+regression+of+disseminated+neuroblastoma+metastases+in+the+liver+and+bone+marrow.&rft.au=Salcedo%2C+Rosalba%3BHixon%2C+Julie+A%3BStauffer%2C+Jimmy+K%3BJalah%2C+Rashmi%3BBrooks%2C+Alan+D%3BKhan%2C+Tahira%3BDai%2C+Ren-Ming%3BScheetz%2C+Loretta%3BLincoln%2C+Erin%3BBack%2C+Timothy+C%3BPowell%2C+Douglas%3BHurwitz%2C+Arthur+A%3BSayers%2C+Thomas+J%3BKastelein%2C+Robert%3BPavlakis%2C+George+N%3BFelber%2C+Barbara+K%3BTrinchieri%2C+Giorgio%3BWigginton%2C+Jon+M&rft.aulast=Salcedo&rft.aufirst=Rosalba&rft.date=2009-04-01&rft.volume=182&rft.issue=7&rft.spage=4328&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.0800471 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-14 N1 - Date created - 2009-03-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Cancer. 2000 May;36(7):901-8 [10785596] Cancer Immunol Immunother. 1997 Jan;43(6):361-7 [9067408] Transplantation. 2000 Oct 15;70(7):1100-4 [11045650] Immunity. 2000 Nov;13(5):715-25 [11114383] Med Pediatr Oncol. 2001 Jan;36(1):213-9 [11464888] J Pediatr Surg. 2001 Aug;36(8):1285-92 [11479878] Immunity. 2002 Jun;16(6):755-8 [12121657] Immunity. 2002 Jun;16(6):779-90 [12121660] J Immunol. 2002 Oct 15;169(8):4467-74 [12370382] J Neuroimmunol. 2002 Dec;133(1-2):60-71 [12446009] J Biol Chem. 2003 Jan 17;278(3):1910-4 [12417590] Nat Rev Immunol. 2003 Feb;3(2):133-46 [12563297] J Pediatr Surg. 2003 Feb;38(2):199-204 [12596103] J Pediatr Surg. 2003 Mar;38(3):301-7; discussion 301-7 [12632339] Int J Cancer. 2003 Jul 20;105(6):820-4 [12767068] Br J Cancer. 2003 May 19;88(10):1641-8 [12771934] Oncologist. 2003;8(3):278-92 [12773750] J Immunother. 2003 May-Jun;26(3):234-40 [12806277] J Immunol. 2003 Jul 15;171(2):600-7 [12847224] J Interferon Cytokine Res. 2003 Sep;23(9):513-22 [14565860] Immunity. 2003 Nov;19(5):641-4 [14614851] Cancer Res. 2004 Feb 1;64(3):1152-6 [14871851] Nat Rev Immunol. 2004 Sep;4(9):665-74 [15343366] Cancer Treat Rev. 1989 Jun;16 Suppl A:129-42 [2670209] Proc Natl Acad Sci U S A. 1990 Sep;87(17):6808-12 [2204066] J Virol. 1992 Jan;66(1):150-9 [1727477] Am J Pediatr Hematol Oncol. 1992 Nov;14(4):305-11 [1456395] J Exp Med. 1993 Oct 1;178(4):1223-30 [8104230] J Immunother Emphasis Tumor Immunol. 1994 Jan;15(1):29-37 [8110728] J Surg Res. 1995 Feb;58(2):218-26 [7861776] Curr Opin Pediatr. 1997 Feb;9(1):55-69 [9088757] Cancer. 1997 Jul 15;80(2):317-33 [9217046] Cancer J Sci Am. 1997 Dec;3 Suppl 1:S121-7 [9457407] J Immunol. 1998 Feb 15;160(4):1742-9 [9469432] Blood. 1998 Mar 1;91(5):1706-15 [9473237] J Clin Invest. 1998 Mar 15;101(6):1441-52 [9502787] Bone Marrow Transplant. 1999 Apr;23(8):789-95 [10231141] J Pediatr Surg. 1999 May;34(5):902-6; discussion 906-7 [10359203] Methods. 1999 Sep;19(1):121-32 [10525448] Immunol Rev. 2004 Dec;202:96-105 [15546388] J Immunol. 2004 Dec 15;173(12):7170-82 [15585838] Curr Opin Pediatr. 2005 Feb;17(1):7-13 [15659956] Anticancer Res. 2004 Nov-Dec;24(6):3763-7 [15736409] Int J Cancer. 2005 Jun 20;115(3):437-42 [15688376] J Immunol. 2005 Jun 15;174(12):7684-91 [15944269] J Immunol. 2005 Aug 1;175(3):1686-93 [16034109] Blood. 2006 Mar 15;107(6):2409-14 [16304057] J Immunol. 2006 Oct 15;177(8):5377-85 [17015723] Immunity. 2007 Mar;26(3):371-81 [17363300] J Immunother. 2007 Feb-Mar;30(2):203-14 [17471167] J Immunol. 2007 Jun 1;178(11):6730-3 [17513719] Eur J Immunol. 2007 Jul;37(7):1809-16 [17549733] Int Immunol. 2008 Feb;20(2):223-34 [18156621] Ann Rheum Dis. 2008 Oct;67(10):1474-9 [18199596] Cancer. 1995 Jun 15;75(12):2959-65 [7773948] Eur J Cancer. 1995;31A(4):553-6 [7576966] J Natl Cancer Inst. 1996 Jan 3;88(1):38-43 [8847724] Int Immunol. 1995 Jul;7(7):1135-45 [8527411] Cancer Chemother Pharmacol. 1996;38 Suppl:S16-21 [8765410] Immunol Rev. 1995 Dec;148:35-44 [8825281] Ann N Y Acad Sci. 1996 Oct 31;795:434-9 [8958976] Bone Marrow Transplant. 2000 Jul;26(1):91-6 [10918410] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.0800471 ER - TY - JOUR T1 - Nicotine abstinence genotyping: assessing the impact on smoking cessation clinical trials. AN - 67051742; 18781146 AB - Twin studies document substantial heritability for successful abstinence from smoking. A genome-wide association study has identified markers whose allele frequencies differ with nominal P<0.005 in nicotine-dependent clinical trial participants who were successful vs unsuccessful in abstaining from smoking; many of these results are also supported by data from two additional samples. More study is required to precisely determine the variance in quitting success that can be accounted for by the single-nucleotide polymorphisms that are currently identified and to precisely classify individuals who may display varying degrees of genetic vs environmental effects into quitters or nonquitters. However, the data at hand do allow us to model the effects of genotypic stratification in smoking cessation trials. We identify relationships between the costs of identifying and genotyping prospective trial participants vs the costs of performing the clinical trials. We quantitate the increasing savings that result from genetically stratified designs as recruiting/genotyping costs go down and trial costs increase. This model helps to define the circumstances in which genetically stratified designs may enhance power and reduce costs for smoking cessation clinical trials. JF - The pharmacogenomics journal AU - Uhl, G R AU - Drgon, T AU - Johnson, C AU - Rose, J E AD - Molecular Neurobiology Branch, NIH-IRP, NIDA, Baltimore, MD 21224, USA. guhl@intra.nida.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 111 EP - 115 VL - 9 IS - 2 KW - Index Medicus KW - Phenotype KW - Genotype KW - Computer Simulation KW - Models, Genetic KW - Humans KW - Treatment Outcome KW - Cost Savings KW - Genetic Testing -- economics KW - Models, Economic KW - Tobacco Use Disorder -- therapy KW - Clinical Trials as Topic -- economics KW - Tobacco Use Disorder -- genetics KW - Smoking Cessation KW - Smoking -- prevention & control KW - Smoking -- genetics KW - Patient Selection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67051742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+pharmacogenomics+journal&rft.atitle=Nicotine+abstinence+genotyping%3A+assessing+the+impact+on+smoking+cessation+clinical+trials.&rft.au=Uhl%2C+G+R%3BDrgon%2C+T%3BJohnson%2C+C%3BRose%2C+J+E&rft.aulast=Uhl&rft.aufirst=G&rft.date=2009-04-01&rft.volume=9&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=The+pharmacogenomics+journal&rft.issn=1473-1150&rft_id=info:doi/10.1038%2Ftpj.2008.10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2009-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addiction. 1997 Apr;92(4):469-72 [9177068] JAMA. 1994 Feb 23;271(8):589-94 [8301790] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Am J Med Genet. 1999 Aug 20;88(4):391-7 [10402507] J Behav Health Serv Res. 2005 Oct-Dec;32(4):381-92 [16215448] Twin Res Hum Genet. 2006 Feb;9(1):64-72 [16611469] Tob Control. 2006 Jun;15(3):152-9 [16728744] BMC Genet. 2007;8:10 [17407593] Psychol Med. 2007 Sep;37(9):1357-67 [17466111] Arch Gen Psychiatry. 2008 Jun;65(6):683-93 [18519826] Am J Med Genet. 2000 Oct 9;96(5):665-70 [11054775] Nicotine Tob Res. 2003 Apr;5(2):245-54 [12745498] N Engl J Med. 1991 Aug 1;325(5):311-5 [2057036] N Engl J Med. 1992 Sep 17;327(12):829-33 [1508241] Psychopharmacology (Berl). 1998 Jun;137(4):345-50 [9676894] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/tpj.2008.10 ER - TY - JOUR T1 - The role of copper in drug-resistant murine and human tumors. AN - 67051606; 18956143 AB - Multidrug resistance (MDR) is still a major threat to successful clinical application of cancer chemotherapy. Copper plays an important role in biological systems, and copper is also involved in carcinogenesis. In the present investigation, we addressed the question whether metal copper might be involved in drug resistance of murine and human tumors. By means of atomic absorption spectroscopy, we determined serum copper concentrations. We found that the blood serum of tumor-bearing mice contained higher amounts of copper than healthy mice with tumors. Secondly, mice bearing doxorubicin-resistant Ehrlich ascites carcinoma- or cyclophosphamide-resistant Lewis lung carcinoma contained more copper in their serum than mice bearing the corresponding drug-sensitive parental tumors. Furthermore, the analysis of patients with breast cancer, colon carcinoma or lung cancer showed that the serum copper contents were higher in patients not responding to chemotherapy when compared to patients whose tumors responded to treatment. The copper levels in serum of healthy volunteers were lower than in cancer patients irrespective of their response to chemotherapy. Our results imply that the level of serum copper may be considered as a biomarker for treatment response. JF - Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine AU - Majumder, S AU - Chatterjee, S AU - Pal, Smarajit AU - Biswas, J AU - Efferth, T AU - Choudhuri, Soumitra Kumar AD - Department of In-Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkatta, 700 026, India. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 377 EP - 384 VL - 22 IS - 2 KW - Copper KW - 789U1901C5 KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Humans KW - Adult KW - Mice, Inbred C57BL KW - Aged KW - Middle Aged KW - Mice KW - Cell Line, Tumor KW - Male KW - Female KW - Drug Resistance, Multiple KW - Neoplasms -- drug therapy KW - Copper -- physiology KW - Drug Resistance, Neoplasm KW - Copper -- blood KW - Copper -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67051606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometals+%3A+an+international+journal+on+the+role+of+metal+ions+in+biology%2C+biochemistry%2C+and+medicine&rft.atitle=The+role+of+copper+in+drug-resistant+murine+and+human+tumors.&rft.au=Majumder%2C+S%3BChatterjee%2C+S%3BPal%2C+Smarajit%3BBiswas%2C+J%3BEfferth%2C+T%3BChoudhuri%2C+Soumitra+Kumar&rft.aulast=Majumder&rft.aufirst=S&rft.date=2009-04-01&rft.volume=22&rft.issue=2&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Biometals+%3A+an+international+journal+on+the+role+of+metal+ions+in+biology%2C+biochemistry%2C+and+medicine&rft.issn=1572-8773&rft_id=info:doi/10.1007%2Fs10534-008-9174-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-13 N1 - Date created - 2009-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10534-008-9174-3 ER - TY - JOUR T1 - The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice. AN - 67051063; 18957951 AB - Neuroinflammation plays a role in the progression of several neurodegenerative disorders. We used a lipopolysaccharide (LPS) model of neuroinflammation to characterize the gene expression changes underlying the inflammatory and behavioral effects of neuroinflammation. A single intracerebroventricular injection of LPS (5 microg) was administered into the lateral ventricle of mice and, 24 h later, we examined gene expression in the cerebral cortex and hippocampus using microarray technology. Gene Ontology (GO) terms for inflammation and the ribosome were significantly enriched by LPS, whereas GO terms associated with learning and memory had decreased expression. We detected 224 changed transcripts in the cerebral cortex and 170 in the hippocampus. Expression of Egr1 (also known as Zif268) and Arc, two genes associated with learning and memory, was significantly lower in the cortex, but not in the hippocampus, of LPS-treated animals. Overall, altered expression of these genes may underlie some of the inflammatory and behavioral effects of neuroinflammation. JF - The pharmacogenomics journal AU - Bonow, R H AU - Aïd, S AU - Zhang, Y AU - Becker, K G AU - Bosetti, F AD - Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-0947, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 116 EP - 126 VL - 9 IS - 2 KW - DNA, Ribosomal KW - 0 KW - Lipopolysaccharides KW - RNA, Messenger KW - Index Medicus KW - Animals KW - Lipopolysaccharides -- administration & dosage KW - Transcription, Genetic -- drug effects KW - Oligonucleotide Array Sequence Analysis KW - RNA, Messenger -- analysis KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Gene Expression Profiling -- methods KW - Injections, Intraventricular KW - Behavior, Animal -- drug effects KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- chemistry KW - Memory -- drug effects KW - Learning -- drug effects KW - Gene Expression Regulation -- drug effects KW - Encephalitis -- genetics KW - Encephalitis -- chemically induced KW - DNA, Ribosomal -- analysis KW - Hippocampus -- chemistry KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67051063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+pharmacogenomics+journal&rft.atitle=The+brain+expression+of+genes+involved+in+inflammatory+response%2C+the+ribosome%2C+and+learning+and+memory+is+altered+by+centrally+injected+lipopolysaccharide+in+mice.&rft.au=Bonow%2C+R+H%3BA%C3%AFd%2C+S%3BZhang%2C+Y%3BBecker%2C+K+G%3BBosetti%2C+F&rft.aulast=Bonow&rft.aufirst=R&rft.date=2009-04-01&rft.volume=9&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=The+pharmacogenomics+journal&rft.issn=1473-1150&rft_id=info:doi/10.1038%2Ftpj.2008.15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2009-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Neurosci. 1999 Dec;2(12):1120-4 [10570490] J Neurosci. 2007 Sep 26;27(39):10445-55 [17898216] Brain Res. 2000 Mar 17;859(1):157-66 [10720625] Nat Genet. 2000 May;25(1):25-9 [10802651] J Neurosci. 2000 Jun 1;20(11):3993-4001 [10818134] J Neurosci. 2007 Dec 5;27(49):13481-90 [18057206] FASEB J. 2008 May;22(5):1491-501 [18162486] J Neuroinflammation. 2008;5:17 [18489773] Mol Cell Biol. 2005 Dec;25(23):10286-300 [16287845] Neurobiol Aging. 2000 May-Jun;21(3):383-421 [10858586] Nat Genet. 2000 Jul;25(3):294-7 [10888876] J Biol Chem. 2000 Aug 25;275(34):26252-8 [10856294] Nat Neurosci. 2001 Mar;4(3):289-96 [11224546] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21 [11309499] Behav Brain Res. 2001 Sep 28;124(1):47-54 [11423165] Methods. 2001 Dec;25(4):402-8 [11846609] J Neurosci. 2002 Apr 1;22(7):2478-86 [11923412] Exp Neurol. 2002 Aug;176(2):336-41 [12359175] J Neurochem. 2002 Oct;83(2):463-70 [12423256] J Mol Diagn. 2003 May;5(2):73-81 [12707371] J Neurosci. 2003 May 1;23(9):3807-19 [12736351] Eur J Neurosci. 2003 May;17(9):1921-7 [12752791] J Neurosci. 2003 Jun 15;23(12):5219-26 [12832546] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13632-7 [14581618] Science. 2003 Dec 5;302(5651):1760-5 [14615545] J Cell Biol. 2003 Dec 22;163(6):1313-26 [14691139] J Neurochem. 2003 Dec;87(6):1518-26 [14713307] Exp Neurol. 2003 Dec;184(2):561-4 [14769349] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2173-8 [14769913] Brain Res. 1988 Nov;464(3):259-62 [3145095] Neurosci Lett. 1989 Jul 3;101(3):274-80 [2505198] Brain Res Mol Brain Res. 1990 Oct;8(4):267-74 [2176705] Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5106-10 [1828891] Brain Res. 1992 Aug 7;587(2):250-6 [1381982] J Neurosci. 1993 Nov;13(11):4776-86 [8229198] Nat Med. 1996 May;2(5):581-4 [8616720] Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):227-32 [8990190] J Neuroimmunol. 1998 May 1;85(1):1-10 [9626992] Infect Dis Clin North Am. 1999 Jun;13(2):341-53, vii [10340170] Neuroscience. 1999;91(3):831-42 [10391466] Prog Neurobiol. 2004 Nov;74(4):183-211 [15556287] J Neurosci. 2005 Jan 19;25(3):723-31 [15659610] FASEB J. 2005 Aug;19(10):1329-31 [15919760] BMC Bioinformatics. 2005;6:144 [15941488] Am J Physiol Gastrointest Liver Physiol. 2005 Sep;289(3):G434-43 [15878984] J Neurochem. 2005 Nov;95(3):796-810 [16248890] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 [16199517] Neurol Clin. 2006 Aug;24(3):521-38 [16877122] J Neurochem. 2006 Aug;98(3):801-11 [16787416] Neuron. 2006 Oct 5;52(1):39-59 [17015226] Neuron. 2006 Nov 9;52(3):403-7 [17088207] Neuron. 2006 Nov 9;52(3):437-44 [17088210] Neuron. 2006 Nov 9;52(3):445-59 [17088211] J Neuroimmunol. 2006 Nov;180(1-2):71-87 [16996144] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] Brain Res. 2007 Jan 26;1130(1):158-66 [17174281] Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7205-10 [17409187] J Clin Invest. 2000 Feb;105(4):497-504 [10683379] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/tpj.2008.15 ER - TY - JOUR T1 - Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6. AN - 67049840; 19258450 AB - MicroRNAs (miRNA) play pivotal roles in controlling cell proliferation and differentiation. Aberrant miRNA expression in human is becoming recognized as a new molecular mechanism of carcinogenesis. However, the causes for alterations in miRNA expression remain largely unknown. Infection with oncogenic human papillomavirus types 16 (HPV16) and 18 (HPV18) can lead to cervical and other ano-genital cancers. Here, we have demonstrated that cervical cancer tissues and cervical cancer-derived cell lines containing oncogenic HPVs display reduced expression of tumor-suppressive miR-34a. The reduction of miR-34a expression in organotypic tissues derived from HPV-containing primary human keratinocytes correlates with the early productive phase and is attributed to the expression of viral E6, which destabilizes the tumor suppressor p53, a known miR-34a transactivator. Knockdown of viral E6 expression in HPV16(+) and HPV18(+) cervical cancer cell lines by siRNAs leads to an increased expression of p53 and miR-34a and accumulation of miR-34a in G(0)/G(1) phase cells. Ectopic expression of miR-34a in HPV18(+) HeLa cells and HPV(-) HCT116 cells results in a substantial induction of cell growth retardation and a moderate cell apoptosis. Together, this is the first time a viral oncoprotein has been shown to regulate cellular miRNA expression. Our data have provided new insights into mechanisms by which high-risk HPVs contribute to the development of cervical cancer. JF - RNA (New York, N.Y.) AU - Wang, Xiaohong AU - Wang, Hsu-Kun AU - McCoy, J Philip AU - Banerjee, Nilam S AU - Rader, Janet S AU - Broker, Thomas R AU - Meyers, Craig AU - Chow, Louise T AU - Zheng, Zhi-Ming AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 637 EP - 647 VL - 15 IS - 4 KW - DNA-Binding Proteins KW - 0 KW - E6 protein, Human papillomavirus type 16 KW - E6 protein, Human papillomavirus type 18 KW - MIRN34 microRNA, human KW - MicroRNAs KW - Oncogene Proteins, Viral KW - Repressor Proteins KW - Index Medicus KW - Gene Knockdown Techniques KW - Humans KW - Adult KW - Middle Aged KW - Cell Line, Tumor KW - Female KW - MicroRNAs -- metabolism KW - Human papillomavirus 16 -- metabolism KW - Repressor Proteins -- metabolism KW - Papillomavirus Infections -- virology KW - Papillomavirus Infections -- metabolism KW - Oncogene Proteins, Viral -- metabolism KW - Human papillomavirus 18 -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67049840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=RNA+%28New+York%2C+N.Y.%29&rft.atitle=Oncogenic+HPV+infection+interrupts+the+expression+of+tumor-suppressive+miR-34a+through+viral+oncoprotein+E6.&rft.au=Wang%2C+Xiaohong%3BWang%2C+Hsu-Kun%3BMcCoy%2C+J+Philip%3BBanerjee%2C+Nilam+S%3BRader%2C+Janet+S%3BBroker%2C+Thomas+R%3BMeyers%2C+Craig%3BChow%2C+Louise+T%3BZheng%2C+Zhi-Ming&rft.aulast=Wang&rft.aufirst=Xiaohong&rft.date=2009-04-01&rft.volume=15&rft.issue=4&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=RNA+%28New+York%2C+N.Y.%29&rft.issn=1469-9001&rft_id=info:doi/10.1261%2Frna.1442309 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-01 N1 - Date created - 2009-03-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 1999 Jul;5(7):1805-15 [10430085] J Virol. 1997 Apr;71(4):2905-12 [9060648] PLoS Biol. 2005 Mar;3(3):e85 [15723116] Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5570-5 [15800047] Oncogene. 2005 Apr 18;24(17):2796-809 [15838516] Nat Methods. 2005 Apr;2(4):269-76 [15782219] J Virol. 2005 Jul;79(14):9301-5 [15994824] EMBO J. 2005 Aug 3;24(15):2768-82 [16037820] Methods Mol Med. 2005;119:171-86 [16350404] Methods Mol Med. 2005;119:187-202 [16353336] Science. 2005 Dec 16;310(5755):1817-21 [16308420] Nat Genet. 2006 Mar;38(3):356-62 [16462742] Oncogene. 2006 Mar 30;25(14):2094-104 [16369495] J Virol. 2006 May;80(9):4249-63 [16611884] Nat Rev Cancer. 2006 Nov;6(11):857-66 [17060945] Science. 2007 Jan 5;315(5808):97-100 [17204650] Nat Rev Mol Cell Biol. 2007 Apr;8(4):275-83 [17380161] RNA. 2007 Jun;13(6):930-6 [17456563] Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9667-72 [17535905] Mol Cell. 2007 Jun 8;26(5):731-43 [17540598] Mol Cell. 2007 Jun 8;26(5):745-52 [17540599] Nature. 2007 Jun 28;447(7148):1130-4 [17554337] Cell. 2007 Jun 29;129(7):1401-14 [17604727] Mol Cell. 2007 Jul 6;27(1):91-105 [17612493] Cell Cycle. 2007 Jul 1;6(13):1586-93 [17554199] Oncogene. 2007 Jul 26;26(34):5017-22 [17297439] Curr Biol. 2007 Aug 7;17(15):1298-307 [17656095] Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15472-7 [17875987] RNA. 2007 Nov;13(11):1894-910 [17872505] Cancer Res. 2007 Dec 1;67(23):11202-8 [18056445] Science. 2008 Mar 7;319(5868):1352-5 [18323444] J Virol. 2008 May;82(10):4862-73 [18321970] PLoS One. 2008;3(7):e2557 [18596939] Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10931-6 [18678906] Nature. 2008 Aug 7;454(7205):780-3 [18596690] Cell Cycle. 2008 Aug 15;7(16):2591-600 [18719384] Genes Dev. 2009 Jan 15;23(2):181-94 [19131434] J Biol Chem. 2000 Jan 7;275(1):18-28 [10617580] J Virol. 2001 Jul;75(13):6121-34 [11390614] J Virol. 2001 Aug;75(16):7583-91 [11462030] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] Oncogene. 2003 Jun 5;22(23):3645-54 [12789273] J Virol. 2003 Dec;77(24):13232-47 [14645580] Science. 2004 Apr 30;304(5671):734-6 [15118162] J Virol. 2004 Nov;78(21):11451-60 [15479788] Int J Cancer. 1989 Apr 15;43(4):672-6 [2467886] Cell. 1990 Dec 21;63(6):1129-36 [2175676] Oncogene. 1991 May;6(5):873-5 [1646990] Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5523-7 [1648218] Proc Natl Acad Sci U S A. 1992 May 15;89(10):4549-53 [1316611] Genes Dev. 1992 Jul;6(7):1131-42 [1321068] Science. 1992 Aug 14;257(5072):971-3 [1323879] Cell Growth Differ. 1992 Aug;3(8):471-83 [1390334] Carcinogenesis. 1993 May;14(5):833-9 [8504475] Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5320-4 [8202487] Genes Dev. 1995 Oct 1;9(19):2335-49 [7557386] J Clin Microbiol. 1996 Mar;34(3):738-44 [8904450] Cell. 2005 Jan 14;120(1):15-20 [15652477] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1261/rna.1442309 ER - TY - JOUR T1 - Isolation of rafts from mouse brain tissue by a detergent-free method. AN - 67044626; 19060326 AB - Membrane rafts are rich in cholesterol and sphingolipids and have specific proteins associated with them. Due to their small size, their identification and isolation have proved to be problematic. Their insolubility in nonionic detergents, such as Triton-X 100, at 4 degrees C has been the most common means of isolation. However, detergent presence can produce artifacts or interfere with ganglioside distribution. The direction is therefore toward the use of detergent-free protocols. We report an optimized method of raft isolation from lipid-rich brain tissue using a detergent-free method. We compared this to Triton-X 100-based isolation along sucrose or Optiprep gradients using the following endpoints: low protein content, high cholesterol content, presence of Flotillin 1 (Flot1), and absence of transferrin receptor (TfR) proteins. These criteria were met in raft fractions isolated in a detergent-free buffer along a sucrose gradient of 5%/35%/42.5%. The use of optiprep gave less consistent results with respect to protein distribution. We demonstrate that clean raft fractions with minimal myelin contamination can be reproducibly obtained in the top three low-density fractions along a sucrose step gradient. JF - Journal of lipid research AU - Persaud-Sawin, Dixie-Ann AU - Lightcap, Samantha AU - Harry, G Jean AD - Laboratory of Molecular Toxicology/Neurotoxicology Group, National Institute of Environmental Health Sciences, RTP, NC 27709, USA. sawind@niehs.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 759 EP - 767 VL - 50 IS - 4 SN - 0022-2275, 0022-2275 KW - Detergents KW - 0 KW - Membrane Lipids KW - Membrane Proteins KW - Nerve Tissue Proteins KW - Receptors, Transferrin KW - flotillins KW - Sucrose KW - 57-50-1 KW - Octoxynol KW - 9002-93-1 KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Centrifugation, Density Gradient KW - Animals KW - Nerve Tissue Proteins -- isolation & purification KW - Mice, Inbred C57BL KW - Membrane Lipids -- isolation & purification KW - Myelin Sheath -- chemistry KW - Mice KW - Cholesterol -- isolation & purification KW - Receptors, Transferrin -- isolation & purification KW - Membrane Proteins -- isolation & purification KW - Cell Fractionation -- methods KW - Brain Chemistry KW - Membrane Microdomains -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67044626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=Isolation+of+rafts+from+mouse+brain+tissue+by+a+detergent-free+method.&rft.au=Persaud-Sawin%2C+Dixie-Ann%3BLightcap%2C+Samantha%3BHarry%2C+G+Jean&rft.aulast=Persaud-Sawin&rft.aufirst=Dixie-Ann&rft.date=2009-04-01&rft.volume=50&rft.issue=4&rft.spage=759&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=00222275&rft_id=info:doi/10.1194%2Fjlr.D800037-JLR200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-22 N1 - Date created - 2009-03-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochim Biophys Acta. 2005 Jan 5;1686(3):200-8 [15629689] Curr Opin Cell Biol. 1997 Aug;9(4):534-42 [9261060] J Neurosci Res. 2005 Apr 1;80(1):114-9 [15704187] J Neurosci Res. 2005 Apr 15;80(2):211-25 [15772981] Annu Rev Phys Chem. 2005;56:309-36 [15796703] J Lipid Res. 2005 May;46(5):1061-7 [15722565] J Neural Transm (Vienna). 2005 Aug;112(8):1049-56 [15583959] Trends Biochem Sci. 2005 Aug;30(8):430-6 [15996869] J Neurochem. 2005 Sep;94(6):1696-710 [16045452] J Neurosci Methods. 2006 Jan 30;150(2):238-41 [16087244] J Biol Chem. 2006 Apr 28;281(17):11872-8 [16507579] J Biol Chem. 2006 Apr 28;281(17):11949-54 [16513632] Nat Rev Mol Cell Biol. 2006 Jun;7(6):456-62 [16625153] Biochem Cell Biol. 2006 Dec;84(6):993-1005 [17215885] Biochimie. 2007 Feb;89(2):192-6 [16935406] J Neurotrauma. 2007 May;24(5):823-34 [17518537] J Histochem Cytochem. 2007 Aug;55(8):805-12 [17409378] Nat Protoc. 2007;2(9):2159-65 [17853872] Glia. 2008 Jan 1;56(1):118-33 [17963267] J Biol Chem. 2007 Dec 14;282(50):36682-91 [17947241] Neurobiol Dis. 2008 Feb;29(2):221-31 [17964175] Methods Mol Biol. 2007;398:21-8 [18214371] Biochim Biophys Acta. 2008 Mar;1780(3):383-92 [18078821] Methods Mol Biol. 2008;440:97-110 [18369940] J Neurochem. 2008 May;105(4):1536-49 [18266936] Glia. 2009 Feb;57(3):320-35 [18756527] Biochem J. 2009 Jan 15;417(2):525-33 [18831713] J Neurochem. 2007 Dec;103(6):2540-55 [17931362] J Neurochem. 2005 Jan;92(1):171-82 [15606906] J Biol Chem. 2000 Jun 9;275(23):17221-4 [10770957] J Cell Biol. 2000 Oct 2;151(1):143-54 [11018060] Trends Cell Biol. 2000 Nov;10(11):459-62 [11050411] Biochim Biophys Acta. 2000 Nov 23;1508(1-2):182-95 [11090825] J Cell Biol. 2001 Apr 30;153(3):529-41 [11331304] Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9 [11413487] Biophys J. 2002 Jan;82(1 Pt 1):274-84 [11751315] J Clin Invest. 2002 Sep;110(5):597-603 [12208858] J Cell Biol. 2003 Jan 6;160(1):113-23 [12515826] Brain Res. 2003 Feb 7;962(1-2):144-50 [12543465] Nat Genet. 2003 Mar;33(3):366-74 [12590258] J Biol Chem. 2003 Apr 25;278(17):14920-5 [12594205] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5795-800 [12721375] Annu Rev Biophys Biomol Struct. 2003;32:257-83 [12543707] Expert Rev Mol Med. 2002 Dec;4(27):1-22 [14987385] Biochem J. 2004 May 15;380(Pt 1):219-30 [14769131] Ann N Y Acad Sci. 2004 Apr;1014:164-9 [15153431] Pediatr Res. 2004 Sep;56(3):449-63 [15240864] Eur J Neurosci. 2004 Oct;20(8):2015-21 [15450080] Cell. 1992 Feb 7;68(3):533-44 [1531449] Anal Biochem. 1994 Aug 1;220(2):360-6 [7978279] Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10104-8 [7479734] J Biol Chem. 1996 Apr 19;271(16):9690-7 [8621645] J Biol Chem. 1997 Mar 14;272(11):7211-22 [9054417] Nature. 1997 Jun 5;387(6633):569-72 [9177342] J Neurol Sci. 2005 Mar 15;229-230:225-32 [15760644] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1194/jlr.D800037-JLR200 ER - TY - JOUR T1 - GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. AN - 67036196; 18818659 AB - The chromosome 4 cluster of GABA(A) receptor genes is predominantly expressed in the brain reward circuitry and this chromosomal region has been implicated in linkage scans for alcoholism. Variation in one chromosome 4 gene, GABRA2, has been robustly associated with alcohol use disorders (AUD) although no functional locus has been identified. As HapMap data reveal moderate long-distance linkage disequilibrium across GABRA2 and the adjacent gene, GABRG1, it is possible that the functional locus is in GABRG1. We genotyped 24 SNPs across GABRG1 and GABRA2 in two population isolates: 547 Finnish Caucasian men (266 alcoholics) and 311 community-derived Plains Indian men and women (181 alcoholics). In both the Plains Indians and the Caucasians: (1) the GABRG1 haplotype block(s) did not extend to GABRA2; (2) GABRG1 haplotypes and SNPs were significantly associated with AUD; (3) there was no association between GABRA2 haplotypes and AUD; (4) there were several common (>or=0.05) haplotypes that spanned GABRG1 and GABRA2 (341 kb), three of which were present in both populations: one of these ancestral haplotypes was associated with AUD, the other two were more common in non-alcoholics; this association was determined by GABRG1; (5) in the Finns, three less common (<0.05) extended haplotypes showed an association with AUD that was determined by GABRA2. Our results suggest that there are likely to be independent, complex contributions from both GABRG1 and GABRA2 to alcoholism vulnerability. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Enoch, Mary-Anne AU - Hodgkinson, Colin A AU - Yuan, Qiaoping AU - Albaugh, Bernard AU - Virkkunen, Matti AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. maenoch@dicbr.niaaa.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 1245 EP - 1254 VL - 34 IS - 5 KW - GABRA2 protein, human KW - 0 KW - GABRG1 protein, human KW - Receptors, GABA-A KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Gene Frequency KW - Finland KW - Humans KW - Sequence Analysis, DNA KW - European Continental Ancestry Group -- genetics KW - Linkage Disequilibrium KW - Indians, North American -- genetics KW - Oklahoma KW - Haplotypes KW - Adult KW - Genetic Predisposition to Disease KW - Female KW - Male KW - Receptors, GABA-A -- genetics KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67036196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=GABRG1+and+GABRA2+as+independent+predictors+for+alcoholism+in+two+populations.&rft.au=Enoch%2C+Mary-Anne%3BHodgkinson%2C+Colin+A%3BYuan%2C+Qiaoping%3BAlbaugh%2C+Bernard%3BVirkkunen%2C+Matti%3BGoldman%2C+David&rft.aulast=Enoch&rft.aufirst=Mary-Anne&rft.date=2009-04-01&rft.volume=34&rft.issue=5&rft.spage=1245&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.171 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2009-03-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Genet Epidemiol. 1999;17 Suppl 1:S421-6 [10597473] Mol Genet Genomics. 2004 Dec;272(5):519-29 [15503142] Neuroscience. 2000;101(4):815-50 [11113332] J Comp Neurol. 2001 May 14;433(4):526-49 [11304716] Drug Discov Today. 2003 May 15;8(10):445-50 [12801796] Am J Hum Genet. 2003 Nov;73(5):1162-9 [14574645] Am J Hum Genet. 2004 Apr;74(4):705-14 [15024690] J Neurochem. 2004 Apr;89(1):7-14 [15030384] Pharmacol Ther. 2004 Mar;101(3):259-81 [15031002] BMC Bioinformatics. 2004 Jul 6;5:89 [15238162] Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):104-9 [15274050] J Neurosci. 1992 Mar;12(3):1040-62 [1312131] Alcohol Clin Exp Res. 2005 Apr;29(4):493-8 [15834213] Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):174-83 [15950776] Hum Hered. 2005;60(2):119-22 [16224189] Psychiatr Genet. 2006 Feb;16(1):9-17 [16395124] Alcohol Clin Exp Res. 2006 Mar;30(3):399-406 [16499480] J Biomol Tech. 2005 Dec;16(4):398-406 [16522862] Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 5;141B(6):599-607 [16874763] Arch Gen Psychiatry. 2006 Sep;63(9):957-68 [16952998] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):854-60 [16894595] Behav Genet. 2006 Sep;36(5):640-50 [16622805] J Stud Alcohol Drugs. 2007 Sep;68(5):625-33 [17690794] J Psychiatr Res. 2008 Feb;42(3):184-91 [17207817] Genomics. 2008 Jan;91(1):61-9 [17976953] Neuropsychopharmacology. 2008 Mar;33(4):837-48 [17507911] Pharmacol Biochem Behav. 2008 Jul;90(1):1-8 [18313124] Pharmacol Biochem Behav. 2008 Jul;90(1):95-104 [18440057] Alcohol Alcohol. 2008 Sep-Oct;43(5):505-15 [18477577] Mol Pharmacol. 1993 Aug;44(2):437-42 [8102787] Am J Med Genet. 1998 May 8;81(3):207-15 [9603606] Am J Med Genet. 1998 May 8;81(3):216-21 [9603607] Pharmacol Rev. 1998 Jun;50(2):291-313 [9647870] Arch Gen Psychiatry. 1998 Nov;55(11):989-94 [9819067] Science. 2000 Oct 6;290(5489):131-4 [11021797] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/npp.2008.171 ER - TY - JOUR T1 - Inheritance of susceptibility to induction of nephroblastomas in the Noble rat. AN - 67029036; 19281789 AB - Noble (Nb) strain rats are susceptible to nephroblastoma induction with transplacental exposure to direct-acting alkylating agent N-nitrosoethylurea (ENU), while F344 strain rats are highly resistant. To study the inheritance of susceptibility to induction of these embryonal renal tumors, fetal Nb and F344 rats and F1, F2 and reciprocal backcross hybrids were exposed transplacentally to ENU once on day 18 of gestation. Nephroblastomas developed in 53% of Nb offspring with no apparent gender difference, while no nephroblastomas developed in inbred F344 offspring. F1 and F2 hybrid offspring had intermediate responses, 28% and 30%, respectively. Nephroblastoma incidence in the offspring of F1 hybrids backcrossed to the susceptible strain Nb was 46%, while that in F1 hybrids backcrossed to resistant strain F344 was much lower (16%). Carcinogenic susceptibility is therefore consistent with the involvement of one major autosomal locus; the operation of a gene dosage effect; and a lack of simple Mendelian dominance for either susceptibility or resistance. Since established Wilms tumor-associated suppressor genes, Wt1 and Wtx, were not mutated in normal or neoplastic tissues, genomic profiling was performed on isolated Nb and F344 metanephric progenitors to identify possible predisposing factors to nephroblastoma induction. Genes preferentially elevated in expression in Nb rat progenitors included Wnt target genes Epidermal growth factor receptor, Inhibitor of DNA binding 2, and Jagged1, which were further increased in nephroblastomas. These studies demonstrate the value of this model for genetic analysis of nephroblastoma development and implicate both the Wnt and Notch pathways in its pathogenesis. JF - Differentiation; research in biological diversity AU - Diwan, Bhalchandra A AU - Timofeeva, Olga AU - Rice, Jerry M AU - Yang, Yili AU - Sharma, Nirmala AU - Fortini, Mark E AU - Wang, Honghe AU - Perantoni, Alan O AD - Basic Research Program, Science Applications International Corporation-Frederick, Inc., National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 424 EP - 432 VL - 77 IS - 4 KW - Alkylating Agents KW - 0 KW - Tumor Suppressor Proteins KW - WT1 Proteins KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Animals KW - Alkylating Agents -- pharmacology KW - Tumor Suppressor Proteins -- genetics KW - Kidney -- drug effects KW - WT1 Proteins -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Rats KW - Rats, Inbred Strains KW - Gene Expression Profiling KW - Rats, Sprague-Dawley KW - Blotting, Western KW - Breeding KW - Mutation KW - Ethylnitrosourea -- pharmacology KW - Female KW - Male KW - Kidney Neoplasms -- genetics KW - Kidney Neoplasms -- physiopathology KW - Genetic Predisposition to Disease KW - Wilms Tumor -- physiopathology KW - Wilms Tumor -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67029036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Differentiation%3B+research+in+biological+diversity&rft.atitle=Inheritance+of+susceptibility+to+induction+of+nephroblastomas+in+the+Noble+rat.&rft.au=Diwan%2C+Bhalchandra+A%3BTimofeeva%2C+Olga%3BRice%2C+Jerry+M%3BYang%2C+Yili%3BSharma%2C+Nirmala%3BFortini%2C+Mark+E%3BWang%2C+Honghe%3BPerantoni%2C+Alan+O&rft.aulast=Diwan&rft.aufirst=Bhalchandra&rft.date=2009-04-01&rft.volume=77&rft.issue=4&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Differentiation%3B+research+in+biological+diversity&rft.issn=1432-0436&rft_id=info:doi/10.1016%2Fj.diff.2008.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-03-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5828-32 [8390684] Biochim Biophys Acta. 1993 Dec 23;1155(3):295-306 [8268188] Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9931-5 [7937920] Science. 1995 Jul 14;269(5221):230-4 [7618084] Carcinogenesis. 1995 Sep;16(9):2023-8 [7554049] J Biol Chem. 1996 May 24;271(21):12414-22 [8647846] Dev Dyn. 1996 Nov;207(3):235-52 [8922523] Development. 1996 Dec;122(12):4159-67 [9012535] Development. 1997 Apr;124(8):1485-95 [9108365] Dev Dyn. 2004 Dec;231(4):828-38 [15499562] J Am Soc Nephrol. 2005 Jun;16(6):1632-44 [15843474] Nature. 2005 Jun 16;435(7044):959-63 [15959515] Gastroenterology. 2005 Jul;129(1):285-302 [16012954] Radiat Res. 2005 Oct;164(4 Pt 2):462-6 [16187750] Trends Mol Med. 2005 Nov;11(11):496-502 [16214417] Nat Cell Biol. 2005 Dec;7(12):1202-12 [16311606] Cancer Invest. 2006 Apr-May;24(3):310-7 [16809160] Development. 2006 Nov;133(22):4427-38 [17035290] Cancer Res. 2006 Dec 15;66(24):11983-90 [17178897] Science. 2007 Feb 2;315(5812):642-5 [17204608] Science. 2007 May 18;316(5827):1043-6 [17510365] Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4360-4 [17646270] Neoplasia. 2007 Jul;9(7):589-600 [17710162] Dev Biol. 2008 Jan 1;313(1):234-45 [18061157] Genome Biol. 2007;8(6):R117 [17577413] Pediatr Dev Pathol. 2010 Jan-Feb;13(1):1-8 [19348510] Mech Dev. 2005 Jun;122(6):765-80 [15905075] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514] J Biol Chem. 2001 Nov 30;276(48):45113-9 [11572874] Cancer. 2001 Dec 15;92(12):3120-9 [11753991] Dev Biol. 2002 May 1;245(1):157-71 [11969263] J Pathol. 2003 Jan;199(1):68-76 [12474228] Kidney Int. 2003 Jun;63(6):2075-87 [12753294] Cancer Cell. 2003 Jun;3(6):525-30 [12842081] Nature. 1969 Jul 12;223(5202):206-7 [5791738] Am J Pathol. 1971 Apr;63(1):37-56 [4323476] Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;82(1):37-64 [4280214] J Natl Cancer Inst. 1975 Jun;54(6):1439-48 [1169326] Gan. 1978 Oct;69(5):719-22 [215483] Environ Health Perspect. 1979 Apr;29:23-27 [116842] Neoplasma. 1980;27(3):229-35 [6256671] Endocrinology. 1981 Nov;109(5):1708-14 [7297501] Proc Natl Acad Sci U S A. 1981 Nov;78(11):6766-70 [6947250] Acta Pathol Jpn. 1982 May;32(3):385-98 [6285663] J Natl Cancer Inst. 1985 Jan;74(1):241-5 [3855483] Carcinogenesis. 1985 Nov;6(11):1551-8 [2996800] Toxicol Pathol. 1986;14(1):112-22 [3012758] Proc Natl Acad Sci U S A. 1987 Sep;84(17):6317-21 [3476947] IARC Sci Publ. 1989;(96):17-34 [2553598] IARC Sci Publ. 1989;(96):75-80 [2807490] Science. 1990 Nov 30;250(4985):1259-62 [2244209] Science. 1992 Jul 31;257(5070):674-8 [1323141] Cancer Res. 1992 Nov 15;52(22):6407-12 [1330293] J Biol Chem. 1993 May 5;268(13):9172-5 [8486616] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.diff.2008.12.003 ER - TY - JOUR T1 - Effect of garlic on lipid peroxidation and antioxidation enzymes in DMBA-induced skin carcinoma. AN - 66981950; 19084378 AB - Naturally occurring phytochemicals display an active cancer preventive strategy to inhibit, delay, or reverse human carcinogenesis. Studies have indicated that certain daily-consumed dietary phytochemicals have cancer protective effects mediated by carcinogens. Lipid peroxide plays a detrimental role in all cancers including skin carcinogenesis. Garlic, a phytochemical, has acquired a special position in the folklore of many cultures as a formidable prophylactic and therapeutic medicinal agent. In this report, we pursue the chemopreventive effect of aqueous garlic on skin carcinogenesis. "Swiss albino mice" were divided into five groups depending on the combination of skin cancer-inducing 7,12-dimethylbenz[a]anthracene and garlic treatments. Histology of the affected skin and biochemical assays for lipid peroxide, catalase, superoxide dismutase, glutathione-S-transferase, and glutathione peroxidase were performed to demonstrate the effect of garlic in mice. Immunoblotting was performed with cyclo-oxygenase-2, p53, and caspase-3 to demonstrate expressions of the respective proteins in skin lysates. Garlic extracts inhibited the oxidative modification of lipids, thus protecting cells from injury by the oxidized molecules. The best chemopreventive action of garlic was observed in mice in which garlic treatment was performed before and after the induction of skin carcinogenesis. Garlic ingestion delayed formation of skin papillomas in animals and simultaneously decreased the size and number of papillomas, which was also reflected in the skin histology of the mice treated. The protective effects against skin cancer elicited by garlic in mice are believed to be due at least in part to the induction cellular defense systems. JF - Nutrition (Burbank, Los Angeles County, Calif.) AU - Das, Ila AU - Saha, Tapas AD - Departments of Cancer Chemoprevention and Cancer Detection and Screening, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 459 EP - 471 VL - 25 IS - 4 SN - 0899-9007, 0899-9007 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Antioxidants KW - Benz(a)Anthracenes KW - Biomarkers KW - Carcinogens KW - Plant Extracts KW - Tumor Suppressor Protein p53 KW - 7,12-dihydroxymethylbenz(a)anthracene KW - 2564-65-0 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Tumor Suppressor Protein p53 -- metabolism KW - Papilloma -- drug therapy KW - 9,10-Dimethyl-1,2-benzanthracene -- adverse effects KW - Body Weight -- drug effects KW - Biomarkers -- metabolism KW - Cyclooxygenase 2 -- metabolism KW - Female KW - Caspase 3 -- metabolism KW - Plant Extracts -- pharmacology KW - Antioxidants -- metabolism KW - Skin -- drug effects KW - Skin -- anatomy & histology KW - Skin Neoplasms -- chemically induced KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Lipid Peroxidation -- drug effects KW - Antineoplastic Agents, Phytogenic -- pharmacology KW - Skin Neoplasms -- pathology KW - Garlic KW - Skin Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66981950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+%28Burbank%2C+Los+Angeles+County%2C+Calif.%29&rft.atitle=Effect+of+garlic+on+lipid+peroxidation+and+antioxidation+enzymes+in+DMBA-induced+skin+carcinoma.&rft.au=Das%2C+Ila%3BSaha%2C+Tapas&rft.aulast=Das&rft.aufirst=Ila&rft.date=2009-04-01&rft.volume=25&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Nutrition+%28Burbank%2C+Los+Angeles+County%2C+Calif.%29&rft.issn=08999007&rft_id=info:doi/10.1016%2Fj.nut.2008.10.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-26 N1 - Date created - 2009-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.nut.2008.10.014 ER - TY - JOUR T1 - Quantification of phase I/II metabolizing enzyme gene expression and polycyclic aromatic hydrocarbon-DNA adduct levels in human prostate. AN - 66964032; 19143007 AB - Studies of migrant populations suggest that dietary and/or environmental factors play a crucial role in the etiology of prostatic adenocarcinoma (CaP). The human prostate consists of the peripheral zone (PZ), transition zone (TZ), and central zone (CZ); CaP occurs most often in the PZ. To investigate the notion that an underlying differential expression of phase I/II genes, and/or the presence of polycyclic aromatic hydrocarbon (PAH)-DNA adducts might explain the elevated PZ susceptibility, we examined prostate tissues (matched tissue sets consisting of PZ and TZ) from men undergoing radical retropubic prostatectomy for CaP (n = 26) or cystoprostatectomy (n = 1). Quantitative gene expression analysis was employed for cytochrome P450 (CYP) isoforms CYP1A1, CYP1B1, and CYP1A2, as well as N-acetyltransferase 1 and 2 (NAT1 and NAT2) and catechol-O-methyl transferase (COMT). CYP1B1, NAT1, and COMT were expressed in all tissue sets; levels of CYP1B1 and NAT1 were consistently higher in the PZ compared to TZ. Immunohistochemistry confirmed the presence of CYP1B1 (nuclear-associated and primarily in basal epithelial cells) and NAT1. Normal tissue from 23 of these aforementioned 27 matched tissue sets was analyzed for PAH-DNA adduct levels using antiserum elicited against DNA modified with r7,t8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydro-benzo[a]pyrene (BPDE). PAH-DNA adduct levels were highest in glandular epithelial cells, but a comparison of PZ and TZ showed no significant differences. Although expression of activating and/or detoxifying enzymes may be higher in the PZ, PAH-DNA adduct levels appear to be similar in both zones. Therefore, factors other than PAH-DNA adducts may be responsible for promotion of tumor formation in the human prostate. (c) 2009 Wiley-Liss, Inc. JF - The Prostate AU - John, Kaarthik AU - Ragavan, Narasimhan AU - Pratt, M Margaret AU - Singh, Paras B AU - Al-Buheissi, Salah AU - Matanhelia, Shyam S AU - Phillips, David H AU - Poirier, Miriam C AU - Martin, Francis L AD - Carcinogen-DNA Interactions Section, LCBG, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 505 EP - 519 VL - 69 IS - 5 KW - DNA Adducts KW - 0 KW - Isoenzymes KW - Polycyclic Aromatic Hydrocarbons KW - polycyclic aromatic hydrocarbons-DNA adduct KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1B1 KW - Catechol O-Methyltransferase KW - EC 2.1.1.6 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - Index Medicus KW - Gene Expression Regulation, Enzymologic KW - Cell Transformation, Neoplastic -- pathology KW - Prostatectomy KW - Disease Susceptibility KW - Humans KW - Cell Transformation, Neoplastic -- metabolism KW - Male KW - Prostatic Neoplasms -- metabolism KW - Adenocarcinoma -- metabolism KW - Prostate -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Prostate -- surgery KW - Arylamine N-Acetyltransferase -- metabolism KW - DNA Adducts -- metabolism KW - Isoenzymes -- metabolism KW - Adenocarcinoma -- pathology KW - Prostatic Neoplasms -- pathology KW - Prostate -- pathology KW - Polycyclic Aromatic Hydrocarbons -- metabolism KW - Catechol O-Methyltransferase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66964032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Prostate&rft.atitle=Quantification+of+phase+I%2FII+metabolizing+enzyme+gene+expression+and+polycyclic+aromatic+hydrocarbon-DNA+adduct+levels+in+human+prostate.&rft.au=John%2C+Kaarthik%3BRagavan%2C+Narasimhan%3BPratt%2C+M+Margaret%3BSingh%2C+Paras+B%3BAl-Buheissi%2C+Salah%3BMatanhelia%2C+Shyam+S%3BPhillips%2C+David+H%3BPoirier%2C+Miriam+C%3BMartin%2C+Francis+L&rft.aulast=John&rft.aufirst=Kaarthik&rft.date=2009-04-01&rft.volume=69&rft.issue=5&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=The+Prostate&rft.issn=1097-0045&rft_id=info:doi/10.1002%2Fpros.20898 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-13 N1 - Date created - 2009-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Rev. 1999 Dec;51(4):593-628 [10581325] Cancer Res. 1994 Jan 1;54(1):89-94 [8261468] Cancer Res. 1997 Jan 15;57(2):195-8 [9000552] Jpn J Cancer Res. 1997 Jul;88(7):644-51 [9310137] J Urol. 1999 Jan;161(1):152-5 [10037388] Carcinogenesis. 1999 Apr;20(4):545-51 [10223180] Mutat Res. 1999 Jul 15;443(1-2):139-47 [10415437] Genomics. 1998 Nov 1;53(3):284-95 [9799594] Carcinogenesis. 1999 Aug;20(8):1591-5 [10426812] Cancer Lett. 1999 Sep 1;143(2):167-71 [10503898] Cancer Res. 2004 Dec 15;64(24):8854-9 [15604244] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Eur J Cancer. 2005 Apr;41(6):834-45 [15808953] Int J Cancer. 2005 Oct 20;117(1):8-13 [15880531] Pharmacogenet Genomics. 2006 Jun;16(6):391-9 [16708048] Am J Epidemiol. 2006 Aug 15;164(4):376-84 [16829552] Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1236-45 [17548691] J Natl Cancer Inst. 2007 Sep 19;99(18):1384-94 [17848670] Mutat Res. 2007 Nov 1;624(1-2):114-23 [17583755] Clin Cancer Res. 2008 Feb 1;14(3):750-7 [18245535] Eur J Cancer. 2008 May;44(7):928-36 [18381236] Lancet Oncol. 2008 May;9(5):445-52 [18424233] Mutat Res. 1991 Mar-Apr;259(3-4):251-61 [2017211] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514] J Natl Cancer Inst Monogr. 2000;(27):67-73 [10963620] J Natl Cancer Inst Monogr. 2000;(27):75-93 [10963621] J Natl Cancer Inst Monogr. 2000;(27):95-112 [10963622] Carcinogenesis. 2000 Sep;21(9):1683-9 [10964100] Cancer Res. 2001 Jan 1;61(1):103-9 [11196146] J Histochem Cytochem. 2001 Feb;49(2):229-36 [11156691] Curr Drug Metab. 2000 Sep;1(2):107-32 [11465078] Eur J Clin Invest. 2001 Oct;31(10):880-6 [11737226] Cancer Lett. 2002 Jan 25;175(2):141-6 [11741741] Carcinogenesis. 2002 Feb;23(2):329-33 [11872641] Int J Mol Med. 2002 Apr;9(4):411-6 [11891538] Ann N Y Acad Sci. 2002 Apr;959:341-54 [11976208] Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1622-9 [12496053] Prostate Cancer Prostatic Dis. 2002;5(2):96-104 [12496996] Carcinogenesis. 2002 Dec;23(12):2043-9 [12507927] Curr Drug Metab. 2003 Feb;4(1):45-58 [12570745] Lancet. 2003 Mar 8;361(9360):859-64 [12642065] J Cell Biochem. 2004 Feb 1;91(2):423-9 [14743400] Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):500-9 [14751521] Mutat Res. 2004 Mar 22;547(1-2):55-62 [15013699] Nat Rev Cancer. 2004 Jul;4(7):519-27 [15229477] Cancer Lett. 2004 Nov 8;215(1):69-78 [15374634] Cancer. 1969 Jan;23(1):24-34 [5763258] J Urol. 1974 Jan;111(1):58-64 [4813554] Cancer Res. 1980 Feb;40(2):412-6 [7356524] J Natl Cancer Inst. 1980 Nov;65(5):1127-39 [6933244] Prostate. 1981;2(1):35-49 [7279811] Am J Surg Pathol. 1988 Aug;12(8):619-33 [2456702] Mutat Res. 1991 Mar-Apr;259(3-4):205-17 [2017208] Br J Cancer. 1991 Jun;63(6):963-6 [2069852] Carcinogenesis. 1991 Aug;12(8):1503-6 [1860171] Epidemiol Rev. 1991;13:200-27 [1765112] Chem Res Toxicol. 1989 Mar-Apr;2(2):104-8 [2519708] Int J Cancer. 2000 Jan 1;85(1):60-7 [10585584] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pros.20898 ER - TY - JOUR T1 - Gender, Development, Values, Adaptation, and Discrimination in Acculturating Adolescents: The Case of Turk Heritage Youth Born and Living in Belgium AN - 61777242; 200926957 AB - This study addressed gender differences and similarities in acculturation, values, adaptation, and perceived discrimination among middle (14--17 years) and late (18--20 years) adolescents. Girls perceived less discrimination and showed better adaptation than did boys. All adolescents valued openness to change and self-transcendence similarly, but older adolescents attached greater importance to their heritage culture and conservatism. Overall, a larger gender gap in acculturation experiences emerged in late adolescence. The findings are discussed with reference to acculturative and developmental processes in a multicultural context. Adapted from the source document. JF - Sex Roles: A Journal of Research AU - Gungor, Derya AU - Bornstein, Marc H AD - Child and Family Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6705 Rockledge Drive, Suite 8030, Bethesda, MD 20892-7971, USA Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 537 EP - 548 PB - Springer Science+Business Media, Inc., New York NY VL - 60 IS - 7-8 SN - 0360-0025, 0360-0025 KW - Values KW - Acculturation KW - Belgium KW - Sex Differences KW - Discrimination KW - Middle Eastern Cultural Groups KW - Adolescents KW - article KW - 0410: group interactions; social group identity & intergroup relations (groups based on race & ethnicity, age, & sexual orientation) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61777242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sex+Roles%3A+A+Journal+of+Research&rft.atitle=Gender%2C+Development%2C+Values%2C+Adaptation%2C+and+Discrimination+in+Acculturating+Adolescents%3A+The+Case+of+Turk+Heritage+Youth+Born+and+Living+in+Belgium&rft.au=Gungor%2C+Derya%3BBornstein%2C+Marc+H&rft.aulast=Gungor&rft.aufirst=Derya&rft.date=2009-04-01&rft.volume=60&rft.issue=7-8&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Sex+Roles%3A+A+Journal+of+Research&rft.issn=03600025&rft_id=info:doi/10.1007%2Fs11199-008-9531-2 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 78 N1 - Last updated - 2016-09-28 N1 - CODEN - SROLDH N1 - SubjectsTermNotLitGenreText - Belgium; Sex Differences; Acculturation; Values; Adolescents; Middle Eastern Cultural Groups; Discrimination DO - http://dx.doi.org/10.1007/s11199-008-9531-2 ER - TY - JOUR T1 - United States National Library of Medicine Drug Information Portal AN - 57729081; 200907820 AB - The Drug Information Portal is a free Web resource from the National Library of Medicine (MM) that provides a user-friendly gateway to current information for more than 15,000 drugs. The site guides users to related resources of NLM, the National Institutes of Health (MW, and other government agencies. Current drug-related information regarding consumer health, clinical trials, AIDS, MeSH pharmacological actions, MEDLINE/PubMed biomedical literature, and physical properties and structure is easily retrieved by searching on a drug name. A varied selection of focused topics in medicine and drugs is also available from displayed subject headings. This column provides background information about the Drug Information Portal, as well as search basics. Adapted from the source document. JF - Medical Reference Services Quarterly AU - Hochstein, Colette AU - Goshorn, Jeanne AU - Chang, Florence AD - Division of Specialized Information Services (SIS), National Library of Medicine, 6707 Democracy Boulevard, Suite 510, Room 515, Bethesda, MD 20892 colette@nlm.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 154 EP - 163 PB - Taylor & Francis, Philadelphia PA VL - 28 IS - 2 SN - 0276-3869, 0276-3869 KW - Clinical trials, databases, drug, drug information, Drug Information Portal, hazardous substances, Internet resources, National Library of Medicine (NLM), public health, PubMed, U.S. Food and Drug Administration (FDA) KW - National Library of Medicine, USA KW - Electronic information services KW - Drug information KW - Portals KW - article KW - 10.14: INFORMATION SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57729081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Reference+Services+Quarterly&rft.atitle=United+States+National+Library+of+Medicine+Drug+Information+Portal&rft.au=Hochstein%2C+Colette%3BGoshorn%2C+Jeanne%3BChang%2C+Florence&rft.aulast=Hochstein&rft.aufirst=Colette&rft.date=2009-04-01&rft.volume=28&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Medical+Reference+Services+Quarterly&rft.issn=02763869&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-08-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Drug information; Electronic information services; Portals; National Library of Medicine, USA ER - TY - JOUR T1 - The Great Contribution: Index Medicus, Index-Catalogue, and IndexCat AN - 57675846; 200907863 AB - Objective: The systematic indexing of medical literature by the Library of the Surgeon-General's Office (now the National Library of Medicine) has been called "America's greatest contribution to medical knowledge." In the 1870s, the library launched two indexes: the Index Medicus and the Index-Catalogue of the Library of the Surgeon-General's Office. Index Medicus is better remembered today as the forerunner of MEDLINE, but Index Medicus began as the junior partner of what the library saw as its major publication, the Index-Catalogue. However, the Index-Catalogue had been largely overlooked by many medical librarians until 2004, when the National Library of Medicine released IndexCat, the online version of Index-Catalogue. Access to this huge amount of material raised new questions: What was the coverage of the Index-Catalogue? How did it compare and overlap with the Index Medicus? Method: Over 1,000 randomly generated Index Medicus citations were cross-referenced in IndexCat. Results: Inclusion, form, content, authority control, and subject headings were evaluated, revealing that the relationship between the two publications was neither simple nor static through time. In addition, the authors found interesting anomalies that shed light on how medical literature was selected and indexed in "Americans greatest contribution to medical knowledge.". Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Greenberg, Stephen J AU - Gallagher, Patricia E AD - History of Medicine Division, National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894 greenbes@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 108 EP - 113 PB - Medical Library Association, Chicago, IL VL - 97 IS - 2 SN - 1536-5050, 1536-5050 KW - Indexing KW - Index Medicus KW - Online cataloguing KW - article KW - 12.11: CATALOGUING AND INDEXING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57675846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=The+Great+Contribution%3A+Index+Medicus%2C+Index-Catalogue%2C+and+IndexCat&rft.au=Greenberg%2C+Stephen+J%3BGallagher%2C+Patricia+E&rft.aulast=Greenberg&rft.aufirst=Stephen&rft.date=2009-04-01&rft.volume=97&rft.issue=2&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-08-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Indexing; Online cataloguing; Index Medicus ER - TY - JOUR T1 - Longitudinal Outcome of Youth Oppositionality: Irritable, Headstrong, and Hurtful Behaviors have Distinctive Predictions AN - 57283938; 200913141 AB - Objective: Oppositional behavior in youths is one of the strongest predictors of a wide range of psychiatric disorders. We test the hypothesis that oppositionality encompasses an Irritable, a Headstrong, and a Hurtful dimension, each with distinct predictions. Method: Longitudinal design combining data from two British national surveys and their respective 3-year follow-ups (N = 7,912). The Developmental and Well-Being Assessment was used to generate DSM-IV diagnoses. Results: The Irritable dimension was the sole predictor of emotional disorders at follow-up and was particularly associated with distress disorders (depression and anxiety) rather than fear disorders (phobias, separation anxiety, and panic disorder), both before and after adjustment for baseline psychopathology. The Headstrong dimension was the only predictor of attention-deficit/hyperactivity disorder at follow-up. Both Headstrong and Hurtful predicted conduct disorder, although only the Headstrong dimension did so after adjustment for baseline psychopathology. The Hurtful dimension was the strongest predictor of aggressive conduct disorder symptoms. Conclusions: Our data suggest a developmental model of mental disorder whereby oppositionality is an interim shared manifestation of different dimensions of psychopathology with distinct outcomes. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Stringaris, Argyris AU - Goodman, Robert AD - Section on Bipolar Spectrum Disorders, Emotion and Development Branch, Mood and Anxiety Program, National Institute of Mental Health, Building 15K, MSC-2670, Bethesda, MD 20892-2670 stringarisa@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 404 EP - 412 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 48 IS - 4 SN - 0890-8567, 0890-8567 KW - Oppositional defiant disorder KW - depression KW - comorbidity KW - emotional disorders KW - attention-deficit/hyperactivity disorder KW - Predictors KW - Attention deficit hyperactivity disorder KW - Psychiatric disorders KW - Young people KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57283938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Longitudinal+Outcome+of+Youth+Oppositionality%3A+Irritable%2C+Headstrong%2C+and+Hurtful+Behaviors+have+Distinctive+Predictions&rft.au=Stringaris%2C+Argyris%3BGoodman%2C+Robert&rft.aulast=Stringaris&rft.aufirst=Argyris&rft.date=2009-04-01&rft.volume=48&rft.issue=4&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e3181984f30 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Predictors; Psychiatric disorders; Oppositional defiant disorder; Attention deficit hyperactivity disorder; Comorbidity; Young people DO - http://dx.doi.org/10.1097/CHI.0b013e3181984f30 ER - TY - JOUR T1 - The familial aggregation of cannabis use disorders AN - 57282189; 200909855 AB - Aims The aim of this paper is to examine the familial aggregation of cannabis use disorders and other psychiatric conditions among first-degree relatives and spouses of probands with a cannabis use disorder. Design Controlled family study methods. Setting Out-patient psychiatric clinics and the local community (same geographic area). Participants Two hundred and sixty-two probands with a life-time history of cannabis use disorder, alcohol dependence, anxiety disorders or no history of any disorder, and their first-degree relatives and spouses. Measurements Cannabis use disorders and other DSM-III-R disorders in the relatives and spouses using the Schedule for Affective Disorders and Schizophrenia. Findings Results reveal an elevated risk of life-time history of cannabis use disorders among siblings [odds ratio (OR: 3.6), adult offspring (OR): 6.9], and spouses (OR: 4.4) of probands with cannabis use disorders. There is a latent familial factor underlying cannabis use disorders that was shared partially with alcohol abuse/dependence. Comorbid mood and anxiety disorders aggregated independently from cannabis use disorders in families. Equal elevation in the magnitude of the association among the first-degree adult relatives and spouses of probands with a cannabis use disorder suggests the probable contribution of both environmental and genetic factors. Conclusions These findings support a family-based approach to drug abuse intervention and the importance of future research concerning environmental mediators of familial transmission of drug abuse. Submitted 17 January 2008; initial review completed 29 April 2008; final version accepted 14 October 2008. Adapted from the source document. JF - Addiction AU - Merikangas, Kathleen R AU - Li, Julan Julia AU - Stipelman, Brooke AU - Yu, Kelly AU - Fucito, Lisa AU - Swendsen, Joel AU - Zhang, Heping AD - Section on Developmental Genetic Epidemiology, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA kathleen.merikangas@nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 622 EP - 629 PB - Blackwell Publishing, Oxford UK VL - 104 IS - 4 SN - 0965-2140, 0965-2140 KW - Alcohol dependence KW - Substance abuse disorders KW - Cannabis KW - Aggregation KW - Relatives KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57282189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=The+familial+aggregation+of+cannabis+use+disorders&rft.au=Merikangas%2C+Kathleen+R%3BLi%2C+Julan+Julia%3BStipelman%2C+Brooke%3BYu%2C+Kelly%3BFucito%2C+Lisa%3BSwendsen%2C+Joel%3BZhang%2C+Heping&rft.aulast=Merikangas&rft.aufirst=Kathleen&rft.date=2009-04-01&rft.volume=104&rft.issue=4&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02468.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Cannabis; Substance abuse disorders; Alcohol dependence; Relatives; Aggregation DO - http://dx.doi.org/10.1111/j.1360-0443.2008.02468.x ER - TY - JOUR T1 - Measures of the Food Environment: A Compilation of the Literature, 1990-2007 AN - 57281580; 200909824 AB - Background Valid and reliable measures are required to assess any effect of the food environment on individual dietary behavior, and form the foundation of research that may inform obesity-related policy. Although many methods of measuring the food environment exist, this area of research is still relatively new and there has been no systematic attempt to gather these measures, to compare and contrast them, or to report on their psychometric properties. Evidence acquisition A structured literature search was conducted to identify peer-reviewed articles published between January 1990 and August 2007 that measured the community-level food environment. These articles were categorized into the following environments: food stores, restaurants, schools, and worksites. The measurement strategies in these studies were categorized as instruments (checklists, market baskets, inventories, or interviews/questionnaires) or methodologies (geographic, sales, menu, or nutrient analyses). Evidence synthesis A total of 137 articles were identified that included measures of the food environment. Researchers focused on assessing the accessibility, availability, affordability, and quality of the food environment. The most frequently used measure overall was some form of geographic analysis. Eighteen of the 137 articles (13.1%) tested for any psychometric properties, including inter-rater reliability, test-retest reliability, and/or validity. Conclusions A greater focus on testing for reliability and validity of measures of the food environment may increase rigor in research in this area. Robust measures of the food environment may strengthen research on the effects of the community-level food environment on individual dietary behavior, assist in the development and evaluation of interventions, and inform policymaking targeted at reducing the prevalence of obesity and improving diet. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - McKinnon, Robin A AU - Reedy, Jill AU - Morrissette, Meredith A AU - Lytle, Leslie A AU - Yaroch, Amy L AD - National Cancer Institute, Bethesda, Maryland mckinnonr@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - S124 EP - S133 PB - Elsevier Science, New York NY VL - 36 IS - 4S1 SN - 0749-3797, 0749-3797 KW - Community based research KW - Literature reviews KW - Environmental aspects KW - Food KW - Measures KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Measures+of+the+Food+Environment%3A+A+Compilation+of+the+Literature%2C+1990-2007&rft.au=McKinnon%2C+Robin+A%3BReedy%2C+Jill%3BMorrissette%2C+Meredith+A%3BLytle%2C+Leslie+A%3BYaroch%2C+Amy+L&rft.aulast=McKinnon&rft.aufirst=Robin&rft.date=2009-04-01&rft.volume=36&rft.issue=4S1&rft.spage=S124&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2009.01.012 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Measures; Food; Environmental aspects; Community based research; Literature reviews DO - http://dx.doi.org/10.1016/j.amepre.2009.01.012 ER - TY - JOUR T1 - Psychopathy, attention and emotion AN - 57276356; 200908301 AB - Psychopathy is a developmental disorder marked by emotional hypo-responsiveness and an increased risk for antisocial behavior. Influential attention-based accounts of psychopathy have long been made; however, these accounts have made relatively little reference to general models of attention in healthy individuals. This review has three aims: (1) to summarize current cognitive neuroscience data on differing attentional systems; (2) to examine the functional integrity of these attentional systems in individuals with psychopathy; and (3) to consider the implications of these data for attention and emotion dysfunction accounts of psychopathy. Adapted from the source document. JF - Psychological Medicine AU - Blair, R J R AU - Mitchell, G V AD - National Institute of Mental Health, National Institutes of Health, 15k North Drive, Bethesda, MD 20892, USA blairj@intra.nimh.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 543 EP - 555 PB - Cambridge University Press, UK VL - 39 IS - 4 SN - 0033-2917, 0033-2917 KW - Antisocial behaviour KW - biased competition model KW - callous-unemotional traits KW - emotional attention KW - psychopathy KW - Developmental disorders KW - Emotions KW - Psychopathy KW - Cognitive neurosciences KW - Dysfunction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Psychopathy%2C+attention+and+emotion&rft.au=Blair%2C+R+J+R%3BMitchell%2C+G+V&rft.aulast=Blair&rft.aufirst=R+J&rft.date=2009-04-01&rft.volume=39&rft.issue=4&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291708003991 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Psychopathy; Emotions; Cognitive neurosciences; Antisocial behaviour; Developmental disorders; Dysfunction DO - http://dx.doi.org/10.1017/S0033291708003991 ER - TY - JOUR T1 - National Comorbidity Survey Replication Adolescent Supplement (NCS-A): I. Background and Measures AN - 57270154; 200912581 AB - Objective: This article presents an overview of the background and measures used in the National Comorbidity Survey Replication Adolescent Supplement (NCS-A). Method: The NCS-A is a national psychiatric epidemiological survey of adolescents aged 13 to 17 years. Results: The NCS-A was designed to provide the first nationally representative estimates of the prevalence, correlates, and patterns of service use for DSM-IV mental disorders among U.S. adolescents and to lay the groundwork for follow-up studies of risk and protective factors, consequences, and early expressions of adult mental disorders. The core NCS-A diagnostic interview, the World Health Organization Composite International Diagnostic Interview, is a fully structured research diagnostic interview designed for use by trained lay interviewers. A multiconstruct, multimethod, and multi-informant battery was also included to assess risk and protective factors and barriers to service use. Design limitations due to the NCS-A evolving as a supplement to an ongoing survey of mental disorders of U.S. adults include restricted age range of youths, cross-sectional assessment, and lack of full parental/surrogate informant reports on youth mental disorders and correlates. Conclusions: Despite these limitations, the NCS-A contains unparalleled information that can be used to generate national estimates of prevalence and correlates of adolescent mental disorders, risk and protective factors, patterns of service use, and barriers to receiving treatment for these disorders. The retrospective NCS-A data on the development of psychopathology can additionally complement data from longitudinal studies based on more geographically restricted samples and serve as a useful baseline for future prospective studies of the onset and progression of mental disorders in adulthood. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Merikangas, Kathleen R AU - Avenevoli, Shelli AU - Costello, E Jane AU - Koretz, Doreen AU - Kessler, Ronald C AD - Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 367 EP - 379 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 48 IS - 4 SN - 0890-8567, 0890-8567 KW - Adolescent mental disorders KW - National Comorbidity Survey Replication Adolescent Supplement KW - Composite International Diagnostic Interview KW - mental disorders KW - epidemiology KW - Protective factors KW - Epidemiology KW - Risk factors KW - Psychiatric disorders KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57270154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=National+Comorbidity+Survey+Replication+Adolescent+Supplement+%28NCS-A%29%3A+I.+Background+and+Measures&rft.au=Merikangas%2C+Kathleen+R%3BAvenevoli%2C+Shelli%3BCostello%2C+E+Jane%3BKoretz%2C+Doreen%3BKessler%2C+Ronald+C&rft.aulast=Merikangas&rft.aufirst=Kathleen&rft.date=2009-04-01&rft.volume=48&rft.issue=4&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e31819996f1 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Adolescents; Epidemiology; Psychiatric disorders; Protective factors; Risk factors DO - http://dx.doi.org/10.1097/CHI.0b013e31819996f1 ER - TY - JOUR T1 - Promoting abstinence from cocaine and heroin with a methadone dose increase and a novel contingency AN - 57256124; 200908808 AB - To test whether a combination of contingency management and methadone dose increase would promote abstinence from heroin and cocaine, we conducted a randomized controlled trial using a 2NBXNB3 (doseNBXNBcontingency) factorial design in which dose assignment was double-blind. Participants were 252 heroin- and cocaine-abusing outpatients on methadone maintenance. They were randomly assigned to methadone dose (70 or 100NBmg/day, double-blind) and voucher condition (noncontingent, contingent on cocaine-negative urines, or "split"). The split contingency was a novel contingency that reinforced abstinence from either drug while doubly reinforcing simultaneous abstinence from both: the total value of incentives was "split" between drugs to contain costs. The main outcome measures were percentages of urine specimens negative for heroin, cocaine, and both simultaneously; these were monitored during a 5-week baseline of standard treatment (to determine study eligibility), a 12-week intervention, and a 10-week maintenance phase (to examine intervention effects in return-to-baseline conditions). DSM-IV criteria for ongoing drug dependence were assessed at study exit. Urine-screen results showed that the methadone dose increase reduced heroin use but not cocaine use. The split 100NBmg group was the only group to achieve a longer duration of simultaneous negatives than its same-dose noncontingent control group. The frequency of DSM-IV opiate and cocaine dependence diagnoses decreased in the active intervention groups. For a split contingency to promote simultaneous abstinence from cocaine and heroin, a relatively high dose of methadone appears necessary but not sufficient; an increase in overall incentive amount may also be required. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Epstein, David H AU - Schmittner, John AU - Umbricht, Annie AU - Schroeder, Jennifer R AU - Moolchan, Eric T AU - Preston, Kenzie L AD - Treatment Section, Clinical Pharmacology & Therapeutics Branch, Intramural Research Branch of the National Institute on Drug Abuse, 251 Bayview Blvd #200, Baltimore, MD 21224, US depstein@intra.nida.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 92 EP - 100 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 101 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Contingency management KW - Polydrug dependence KW - Methadone dose KW - DSM diagnoses KW - Abstinence KW - Methadone KW - Urine KW - Heroin KW - Contingencies KW - Cocaine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57256124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Promoting+abstinence+from+cocaine+and+heroin+with+a+methadone+dose+increase+and+a+novel+contingency&rft.au=Epstein%2C+David+H%3BSchmittner%2C+John%3BUmbricht%2C+Annie%3BSchroeder%2C+Jennifer+R%3BMoolchan%2C+Eric+T%3BPreston%2C+Kenzie+L&rft.aulast=Epstein&rft.aufirst=David&rft.date=2009-04-01&rft.volume=101&rft.issue=1-2&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2008.11.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Methadone; Heroin; Cocaine; Abstinence; Contingencies; Urine DO - http://dx.doi.org/10.1016/j.drugalcdep.2008.11.006 ER - TY - JOUR T1 - Toxicity testing in the 21st century: implications for human health risk assessment AN - 37281970; 3940576 JF - Risk analysis AU - Kavlock, Robert J AU - Austin, Christopher P AU - Tice, Raymond R AD - US Environmental Protection Agency ; NIH Chemical Genomics Center ; National Institute of Environmental Health Sciences, USA Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 485 EP - 487 VL - 29 IS - 4 SN - 0272-4332, 0272-4332 KW - Economics KW - Environment KW - Risk KW - Health KW - Toxicity KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37281970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=Toxicity+testing+in+the+21st+century%3A+implications+for+human+health+risk+assessment&rft.au=Kavlock%2C+Robert+J%3BAustin%2C+Christopher+P%3BTice%2C+Raymond+R&rft.aulast=Kavlock&rft.aufirst=Robert&rft.date=2009-04-01&rft.volume=29&rft.issue=4&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2008.01168.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11035; 5772; 4309; 12807 9818; 7994 DO - http://dx.doi.org/10.1111/j.1539-6924.2008.01168.x ER - TY - JOUR T1 - Modelling population-based cancer survival trends by using join point models for grouped survival data AN - 37113293; 3845397 AB - In the USA cancer as a whole is the second leading cause of death and a major burden to health care; thus medical progress against cancer is a major public health goal. There are many individual studies to suggest that cancer treatment breakthroughs and early diagnosis have significantly improved the prognosis of cancer patients. To understand better the relationship between medical improvements and the survival experience for the patient population at large, it is useful to evaluate cancer survival trends on the population level, e.g. to find out when and how much the cancer survival rates changed. We analyse population-based grouped cancer survival data by incorporating join points into the survival models. A join point survival model facilitates the identification of trends with significant change-points in cancer survival, when related to cancer treatments or interventions. The Bayesian information criterion is used to select the number of join points. The performance of the join point survival models is evaluated with respect to cancer prognosis, join point locations, annual percentage changes in death rates by year of diagnosis and sample sizes through intensive simulation studies. The model is then applied to grouped relative survival data for several major cancer sites from the 'Surveillance, epidemiology and end results' programme of the National Cancer Institute. The change-points in the survival trends for several major cancer sites are identified and the potential driving forces behind such change-points are discussed. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Yu, B. AU - Huang, L AU - Tiwari, R C AU - Feuer, E J AU - Johnson, K A AD - US National Institutes of Health ; US National Cancer Institute Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 405 EP - 426 VL - 172 IS - 2 SN - 0964-1998, 0964-1998 KW - Sociology KW - Economics KW - Epidemiology KW - Medical research KW - Survival KW - Patients KW - U.S.A. KW - Statistical methods KW - Cancer KW - Population statistics KW - Bayesian method UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37113293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Modelling+population-based+cancer+survival+trends+by+using+join+point+models+for+grouped+survival+data&rft.au=Yu%2C+B.%3BHuang%2C+L%3BTiwari%2C+R+C%3BFeuer%2C+E+J%3BJohnson%2C+K+A&rft.aulast=Yu&rft.aufirst=B.&rft.date=2009-04-01&rft.volume=172&rft.issue=2&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=09641998&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 7886 10902; 9879 12233; 1939 3617 6220; 12430; 9271 7890 5792 10484; 1512 3865 4025; 4357 7894; 433 293 14 ER - TY - JOUR T1 - Evidence for substance abuse services and policy research: a systematic review of national databases AN - 37104847; 3851964 AB - We reviewed 39 national government- and nongovernment-sponsored data sets related to substance addiction policy. These data sets describe patients with substance use disorders (SUDs), treatment providers and the services they offer, and/or expenditures on treatment. Findings indicate the availability of reliable data on the prevalence of SUD and the characteristics of specialty treatment facilities, but meager data on financing and services. Gaps in information might be filled through agency collaboration to redesign, coordinate, and augment existing substance abuse and general health surveys. Despite noted gaps, these data sets represent an unusually rich set of resources for health services and policy research. Reprinted by permission of Sage Publications, Inc. JF - Evaluation review AU - Coffey, Rosanna AU - Levit, Katharine AU - Kassed, Cheryl AU - McLellan, A AU - Chalk, Mady AU - Brady, Thomas AU - Vandivort-Warren, Rita AD - Thomson Reuters ; Treatment Research Institute ; National Institute on Drug Abuse ; Substance Abuse and Mental Health Services Administration Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 103 EP - 137 VL - 33 IS - 2 SN - 0193-841X, 0193-841X KW - Sociology KW - Financing methods KW - Medical treatment KW - Data analysis KW - Drug addiction KW - Drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37104847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation+review&rft.atitle=Evidence+for+substance+abuse+services+and+policy+research%3A+a+systematic+review+of+national+databases&rft.au=Coffey%2C+Rosanna%3BLevit%2C+Katharine%3BKassed%2C+Cheryl%3BMcLellan%2C+A%3BChalk%2C+Mady%3BBrady%2C+Thomas%3BVandivort-Warren%2C+Rita&rft.aulast=Coffey&rft.aufirst=Rosanna&rft.date=2009-04-01&rft.volume=33&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Evaluation+review&rft.issn=0193841X&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7890 5792 10484; 3742 1121 11776 3753 3755; 3744 561 6220; 3279 971 3286; 4968 4908 ER - TY - JOUR T1 - Codon-Optimized Fluorescent Proteins Designed for Expression in Low-GC Gram-Positive Bacteria AN - 21499087; 12510729 AB - Fluorescent proteins have wide applications in biology. However, not all of these proteins are properly expressed in bacteria, especially if the codon usage and genomic GC content of the host organism are not ideal for high expression. In this study, we analyzed the DNA sequences of multiple fluorescent protein genes with respect to codons and GC content and compared them to a low-GC gram-positive bacterium, Bacillus anthracis. We found high discrepancies for cyan fluorescent protein (CFP), yellow fluorescent protein (YFP), and the photoactivatable green fluorescent protein (PAGFP), but not GFP, with regard to GC content and codon usage. Concomitantly, when the proteins were expressed in B. anthracis, CFP- and YFP-derived fluorescence was undetectable microscopically, a phenomenon caused not by lack of gene transcription or degradation of the proteins but by lack of protein expression. To improve expression in bacteria with low genomic GC contents, we synthesized a codon-optimized gfp and constructed optimized photoactivatable pagfp, cfp, and yfp, which were in contrast to nonoptimized genes highly expressed in B. anthracis and in another low-GC gram-positive bacterium, Staphylococcus aureus. Using optimized GFP as a reporter, we were able to monitor the activity of the protective antigen promoter of B. anthracis and confirm its dependence on bicarbonate and regulators present on virulence plasmid pXO1. JF - Applied and Environmental Microbiology AU - Sastalla, Inka AU - Chim, Kannie AU - C Cheung, Gordon Y AU - Pomerantsev, Andrei P AU - Leppla, Stephen H AD - Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-3202, sleppla@niaid.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 2099 EP - 2110 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 75 IS - 7 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids KW - Bicarbonate KW - Guanylate cyclase KW - Bacillus anthracis KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21499087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Codon-Optimized+Fluorescent+Proteins+Designed+for+Expression+in+Low-GC+Gram-Positive+Bacteria&rft.au=Sastalla%2C+Inka%3BChim%2C+Kannie%3BC+Cheung%2C+Gordon+Y%3BPomerantsev%2C+Andrei+P%3BLeppla%2C+Stephen+H&rft.aulast=Sastalla&rft.aufirst=Inka&rft.date=2009-04-01&rft.volume=75&rft.issue=7&rft.spage=2099&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02066-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Guanylate cyclase; Bacillus anthracis DO - http://dx.doi.org/10.1128/AEM.02066-08 ER - TY - JOUR T1 - Quality assurance of research protocols conducted in the community: The National Institute on Drug Abuse Clinical Trials Network Experience AN - 21337452; 9398780 AB - Background: Quality assurance (QA) of clinical trials is essential to protect the welfare of trial participants and the integrity of the data collected. However, there is little detailed information available on specific procedures and outcomes of QA monitoring for clinical trials.Purpose: This article describes the experience of the National Institute on Drug Abuse's (NIDA) National Drug Abuse Treatment Clinical Trials Network (CTN) in devising and implementing a three-tiered QA model for rigorous multi-site randomized clinical trials implemented in community-based substance abuse treatment programs. The CTN QA model combined local and national resources and was developed to address the unique needs of clinical trial sites with limited research experience.Methods: The authors reviewed internal records maintained by the sponsor, a coordinating site (Lead Nodes), and a local site detailing procedural development, training sessions, protocol violation monitoring, and site visit reporting.Results: Between January 2001 and September 2005, the CTN implemented 21 protocols, of which 18 were randomized clinical trials, one was a quality improvement study and two were surveys. Approximately 160 community-based treatment programs participated in the 19 studies that were monitored, with a total of 6560 participants randomized across the sites. During this time 1937 QA site visits were reported across the three tiers of monitoring and the cost depended on the location of the sites and the salaries of the staff involved. One study reported 109 protocol violations (M = 15.6). Examples are presented to highlight training, protocol violation monitoring, site visit frequency and intensity and cost considerations.Limitations: QA data from the entire network were not easily available for review as much of the data were not electronically accessible. The authors reviewed and discussed a representative sample of internal data from the studies and participating sites.Conclusions: The lessons learned from the CTN's experience include the need for balancing thoroughness with efficiency, monitoring early, assessing research staff abilities in order to judge the need for proactive, focused attention, providing targeted training sessions, and developing flexible tools. The CTN model can work for sponsors overseeing studies at sites with limited research experience that require more frequent, in-depth monitoring. We recommend that sponsors not develop a rigid monitoring approach, but work with the study principal investigators to determine the intensity of monitoring needed depending on trial complexity, the risks of the intervention(s), and the experience of the staff with clinical research. After careful evaluation, sponsors should then determine the best approach to site monitoring and what resources will be needed. Clinical Trials 2009; 6: 151-161. http://ctj.sagepub.com JF - Clinical Trials AU - Rosa, Carmen AU - Campbell, Aimee AU - Kleppinger, Cynthia AU - Sampson, Royce AU - Tyson, Clare AU - Mamay-Gentilin, Stephanie AD - Center for the Clinical Trials Network, National Institute on Drug Abuse, 6001 Executive Blvd., Bethesda, MD 20892 USA, crosa@nida.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 151 EP - 161 PB - Sage Publications Ltd., 6 Bonhill St. VL - 6 IS - 2 SN - 1740-7745, 1740-7745 KW - Risk Abstracts KW - substance abuse KW - Efficiency KW - Training KW - Reviews KW - quality assurance KW - clinical trials KW - Drug abuse KW - community involvement KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21337452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Quality+assurance+of+research+protocols+conducted+in+the+community%3A+The+National+Institute+on+Drug+Abuse+Clinical+Trials+Network+Experience&rft.au=Rosa%2C+Carmen%3BCampbell%2C+Aimee%3BKleppinger%2C+Cynthia%3BSampson%2C+Royce%3BTyson%2C+Clare%3BMamay-Gentilin%2C+Stephanie&rft.aulast=Rosa&rft.aufirst=Carmen&rft.date=2009-04-01&rft.volume=6&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774509102560 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - substance abuse; Efficiency; Training; quality assurance; Reviews; Drug abuse; clinical trials; community involvement DO - http://dx.doi.org/10.1177/1740774509102560 ER - TY - JOUR T1 - Non-Cleavage Site Gag Mutations in Amprenavir-Resistant Human Immunodeficiency Virus Type 1 (HIV-1) Predispose HIV-1 to Rapid Acquisition of Amprenavir Resistance but Delay Development of Resistance to Other Protease Inhibitors AN - 21329285; 11915764 AB - In an attempt to determine whether mutations in Gag in human immunodeficiency virus type 1 (HIV-1) variants selected with a protease inhibitor (PI) affect the development of resistance to the same or a different PI(s), we generated multiple infectious HIV-1 clones carrying mutated Gag and/or mutated protease proteins that were identified in amprenavir (APV)-selected HIV-1 variants and examined their virological characteristics. In an HIV-1 preparation selected with APV (33 passages, yielding HIVAPVp33), we identified six mutations in protease and six apparently critical mutations at cleavage and non-cleavage sites in Gag. An infectious recombinant clone carrying the six protease mutations but no Gag mutations failed to replicate, indicating that the Gag mutations were required for the replication of HIVAPVp33. An infectious recombinant clone that carried wild-type protease and a set of five Gag mutations (rHIVWTpro12/75/219/390/409gag) replicated comparably to wild-type HIV-1; however, when exposed to APV, rHIVWTpro12/75/219/390/409gag rapidly acquired APV resistance. In contrast, the five Gag mutations significantly delayed the acquisition of HIV-1 resistance to ritonavir and nelfinavir (NFV). Recombinant HIV-1 clones containing NFV resistance-associated mutations, such as D30N and N88S, had increased susceptibilities to APV, suggesting that antiretroviral regimens including both APV and NFV may bring about favorable antiviral efficacy. The present data suggest that the preexistence of certain Gag mutations related to PI resistance can accelerate the emergence of resistance to the PI and delay the acquisition of HIV resistance to other PIs, and these findings should have clinical relevance in the therapy of HIV-1 infection with PI-including regimens. JF - Journal of Virology AU - Aoki, Manabu AU - Venzon, David J AU - Koh, Yasuhiro AU - Aoki-Ogata, Hiromi AU - Miyakawa, Toshikazu AU - Yoshimura, Kazuhisa AU - Maeda, Kenji AU - Mitsuya, Hiroaki AD - Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto 860-8556, Japan, hm21q@nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 3059 EP - 3068 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 83 IS - 7 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Data processing KW - Replication KW - Proteinase inhibitors KW - Disease resistance KW - Infection KW - Gag protein KW - Antiviral agents KW - Ritonavir KW - Human immunodeficiency virus 1 KW - Nelfinavir KW - Mutation KW - amprenavir KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21329285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Non-Cleavage+Site+Gag+Mutations+in+Amprenavir-Resistant+Human+Immunodeficiency+Virus+Type+1+%28HIV-1%29+Predispose+HIV-1+to+Rapid+Acquisition+of+Amprenavir+Resistance+but+Delay+Development+of+Resistance+to+Other+Protease+Inhibitors&rft.au=Aoki%2C+Manabu%3BVenzon%2C+David+J%3BKoh%2C+Yasuhiro%3BAoki-Ogata%2C+Hiromi%3BMiyakawa%2C+Toshikazu%3BYoshimura%2C+Kazuhisa%3BMaeda%2C+Kenji%3BMitsuya%2C+Hiroaki&rft.aulast=Aoki&rft.aufirst=Manabu&rft.date=2009-04-01&rft.volume=83&rft.issue=7&rft.spage=3059&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.02539-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 49 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Data processing; Antiviral agents; Ritonavir; Replication; Proteinase inhibitors; Disease resistance; Infection; Nelfinavir; Mutation; Gag protein; amprenavir; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/JVI.02539-08 ER - TY - JOUR T1 - Predicting Clearance of Colonization with Vancomycin-Resistant Enterococci and Methicillin-Resistant Staphylococcus aureus by Use of Weekly Surveillance Cultures AN - 21309872; 12511742 AB - We analyzed surveillance cultures for vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) collected during a multicenter trial to determine if three negative cultures collected at weekly intervals would predict clearance of VRE or MRSA from colonized patients. Seventy-two percent of VRE-colonized patients and 94% of MRSA-colonized patients were culture negative after three consecutive negative cultures. JF - Journal of Clinical Microbiology AU - Huckabee, Charmaine M AU - Huskins, WCharles AU - Murray, Patrick R AD - National Institutes of Health Clinical Center, Bethesda, Maryland, pmurray@cc.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1229 EP - 1230 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 47 IS - 4 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Colonization KW - Drug resistance KW - Staphylococcus aureus KW - Clinical trials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21309872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosomatic+Research&rft.atitle=Is+there+an+association+between+adolescent+sleep+restriction+and+obesity&rft.au=Roberts%2C+Robert+E.%3BDuong%2C+Hao+T.&rft.aulast=Roberts&rft.aufirst=Robert&rft.date=2015-12-01&rft.volume=79&rft.issue=6&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosomatic+Research&rft.issn=00223999&rft_id=info:doi/10.1016%2Fj.jpsychores.2015.05.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Colonization; Drug resistance; Clinical trials; Staphylococcus aureus DO - http://dx.doi.org/10.1128/JCM.02424-08 ER - TY - JOUR T1 - Accelerated Metabolism of Voriconazole and Its Partial Reversal by Cimetidine AN - 21289119; 11811251 AB - We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of cimetidine as a cytochrome P450 enzyme inhibitor. JF - Antimicrobial Agents & Chemotherapy AU - Moriyama, Brad AU - Elinoff, Jason AU - Danner, Robert L AU - Gea-Banacloche, Juan AU - Pennick, Gennethel AU - Rinaldi, Michael G AU - Walsh, Thomas J AD - National Cancer Institute, Bethesda, Maryland, walsht@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1712 EP - 1714 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 53 IS - 4 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Case reports KW - Body weight KW - Lung KW - Voriconazole KW - Enzymes KW - Aspergillosis KW - Aspergillus KW - Cytochrome P450 KW - Cimetidine KW - Metabolism KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21289119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Accelerated+Metabolism+of+Voriconazole+and+Its+Partial+Reversal+by+Cimetidine&rft.au=Moriyama%2C+Brad%3BElinoff%2C+Jason%3BDanner%2C+Robert+L%3BGea-Banacloche%2C+Juan%3BPennick%2C+Gennethel%3BRinaldi%2C+Michael+G%3BWalsh%2C+Thomas+J&rft.aulast=Moriyama&rft.aufirst=Brad&rft.date=2009-04-01&rft.volume=53&rft.issue=4&rft.spage=1712&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01221-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Body weight; Case reports; Lung; Voriconazole; Enzymes; Aspergillosis; Cytochrome P450; Cimetidine; Metabolism; Aspergillus DO - http://dx.doi.org/10.1128/AAC.01221-08 ER - TY - JOUR T1 - High cell density production of Deinococcus radiodurans under optimized conditions AN - 21252350; 11726482 AB - Deinococcus radiodurans is a bacterium being investigated for mechanisms of extreme radiation resistance and for bioremediation of environmental radioactive waste sites. In both fundamental and applied research settings, methods for large-scale production of D. radiodurans are needed. In this study, a systematic investigation was carried out to optimize D. radiodurans production at the 20-L fermentor scale. In defined medium, the phosphate buffer typically used was found to be inhibitory to D. radiodurans growth, and caused cell aggregation. Substitution of HEPES and MOPS buffers for phosphate buffer improved D. radiodurans growth characteristics. Several antifoaming agents were investigated to support large-scale production with submerged aeration, and the defoamer KFO 673 was chosen based on its ability to prevent foaming without affecting D. radiodurans growth. The conventional undefined rich medium tryptone/glucose/yeast extract (TGY) maximally supported D. radiodurans growth to an OD sub(600) of 10. Using a 'design of experiments' approach, we found glucose, Mg and Mn to be critical in supporting high-density growth of D. radiodurans. The optimal pH and temperature for D. radiodurans growth in large-scale preparations were 7.0 and 37C, respectively. Growth was carried out in a 20-L fermentor using the newly developed media under the optimal conditions. With addition of 10g/L glucose, 0.5g/L MgSO sub(4).7H sub(2)O, 5kM MnCl sub(2) into TGY media, an OD sub(600) of 40 was achieved. JF - Journal of Industrial Microbiology & Biotechnology AU - He, Yi AD - Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, MD, 20892, USA, hey4@nhlbi.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 539 EP - 546 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 36 IS - 4 SN - 1367-5435, 1367-5435 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Bioremediation KW - Cell density KW - Glucose KW - Radioactive wastes KW - Foaming KW - Aeration KW - Phosphate KW - Radiation KW - Cell aggregation KW - Deinococcus radiodurans KW - pH effects KW - Manganese KW - J 02310:Genetics & Taxonomy KW - A 01310:Products of Microorganisms KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21252350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.atitle=High+cell+density+production+of+Deinococcus+radiodurans+under+optimized+conditions&rft.au=He%2C+Yi&rft.aulast=He&rft.aufirst=Yi&rft.date=2009-04-01&rft.volume=36&rft.issue=4&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.issn=13675435&rft_id=info:doi/10.1007%2Fs10295-008-0524-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Temperature effects; Bioremediation; Radiation; Phosphate; Cell aggregation; Cell density; Radioactive wastes; Glucose; Aeration; Manganese; pH effects; Foaming; Deinococcus radiodurans DO - http://dx.doi.org/10.1007/s10295-008-0524-5 ER - TY - JOUR T1 - Rapid Myeloid Cell Transcriptional and Proteomic Responses to Periodontopathogenic Porphyromonas gingivalis AN - 21196232; 11664383 AB - Long-lived monocytes, macrophages, and dendritic cells (DCs) are Toll-like receptor-expressing, antigen-presenting cells derived from a common myeloid lineage that play key roles in innate and adaptive immune responses. Based on immunohistochemical and molecular analyses of inflamed tissues from patients with chronic destructive periodontal disease, these cells, found in the inflammatory infiltrate, may drive the progressive periodontal pathogenesis. To investigate early transcriptional signatures and subsequent proteomic responses to the periodontal pathogen, Porphyromonas gingivalis, donor-matched human blood monocytes, differentiated DCs, and macrophages were exposed to P. gingivalis lipopolysaccharide (LPS) and gene expression levels were measured by oligonucleotide microarrays. In adcition to striking differences in constitutive transcriptional profiles between these myeloid populations, we identify a P. gingivalis LPS-inducible convergent, transcriptional core response of more than 400 annotated genes/ESTs among these populations, reflected by a shared, but quantitatively distinct, proteomic response. Nonetheless, clear differences emerged between the monocytes, DCs, and macrophages. The finding that long-lived myeloid inflammatory cells, particularly DCs, rapidly and aggressively respond to P. gingivalis LPS by generating chemokines, proteases, and cytokines capable of driving T-helper cell lineage polarization without evidence of corresponding immunosuppressive pathways highlights their prominent role in host defense and progressive tissue pathogenesis. The shared, unique, and/or complementary transcriptional and proteomic profiles may frame the context of the host response to P. gingivalis, contributing to the destructive nature of periodontal inflammation. JF - American Journal of Pathology AU - Nares, S AU - Moutsopoulos, N M AU - Angelov, N AU - Ranged, Z G AU - Munson, P J AU - Sinha, N AU - Wahl, S M AD - Oral Infection and Immunity Branch, Center for Information Technology, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1400 EP - 1414 VL - 174 IS - 4 SN - 0002-9440, 0002-9440 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Cell lineage KW - Macrophages KW - Chemokines KW - Porphyromonas gingivalis KW - Transcription KW - Pathogens KW - Myeloid cells KW - Polarization KW - DNA microarrays KW - expressed sequence tags KW - Oligonucleotides KW - Inflammation KW - Gene expression KW - Periodontal diseases KW - Dendritic cells KW - Blood KW - Cytokines KW - Lipopolysaccharides KW - Proteinase KW - Antigen-presenting cells KW - Monocytes KW - proteomics KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21196232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Pathology&rft.atitle=Rapid+Myeloid+Cell+Transcriptional+and+Proteomic+Responses+to+Periodontopathogenic+Porphyromonas+gingivalis&rft.au=Nares%2C+S%3BMoutsopoulos%2C+N+M%3BAngelov%2C+N%3BRanged%2C+Z+G%3BMunson%2C+P+J%3BSinha%2C+N%3BWahl%2C+S+M&rft.aulast=Nares&rft.aufirst=S&rft.date=2009-04-01&rft.volume=174&rft.issue=4&rft.spage=1400&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Pathology&rft.issn=00029440&rft_id=info:doi/10.2353%2Fajpath.2009.080677 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Macrophages; Cell lineage; Chemokines; Transcription; Pathogens; Polarization; Myeloid cells; Oligonucleotides; expressed sequence tags; DNA microarrays; Inflammation; Periodontal diseases; Gene expression; Blood; Dendritic cells; Lipopolysaccharides; Cytokines; Proteinase; proteomics; Monocytes; Antigen-presenting cells; Porphyromonas gingivalis DO - http://dx.doi.org/10.2353/ajpath.2009.080677 ER - TY - JOUR T1 - Sample size re-estimation in clinical trials AN - 21069860; 11133107 AB - Adaptive clinical trials are becoming very popular because of their flexibility in allowing mid-stream changes of sample size, endpoints, populations, etc. At the same time, they have been regarded with mistrust because they can produce bizarre results in very extreme settings. Understanding the advantages and disadvantages of these rapidly developing methods is a must. This paper reviews flexible methods for sample size re-estimation when the outcome is continuous. JF - Biometrical Journal AU - Proschan, Michael A AD - National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-7609, USA, ProschaM@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 348 EP - 357 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 2 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Clinical trials KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21069860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Sample+size+re-estimation+in+clinical+trials&rft.au=Proschan%2C+Michael+A&rft.aulast=Proschan&rft.aufirst=Michael&rft.date=2009-04-01&rft.volume=51&rft.issue=2&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200800266 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Clinical trials DO - http://dx.doi.org/10.1002/bimj.200800266 ER - TY - JOUR T1 - Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis AN - 20869990; 9356245 AB - Genetic variation in SIPA1, signal-induced proliferation-associated gene 1, has been proposed to be associated with aggressive breast tumor characteristics related to metastasis and worse prognosis in humans and rodents. To test this hypothesis, we genotyped 3 single nucleotide polymorphisms (SNP) located at -3092 (AT, rs3741378), and exon 14 + 14 (C>T, rs746429), and examined them in relation to breast cancer risk and overall survival, stratified by tumor characteristics in 2 independent case-control studies conducted in Poland (1,995 cases, 2,296 controls) and in Britain (2,142 cases, 2,257 controls). Vital status (n = 396 deaths) was available for 911 Polish and 1,919 British breast cancer cases with an average follow-up time of 5.5 years. Overall, we found no significant associations between genetic variants of SIPA1 SNPs and breast cancer risk (per allele odds ratios, 95% confidence intervals (CI): rs931127-0.9,0.93-1.06; rs3741378-1.03, 0.94-1.13; and, rs74642-0.9,0.92-1.04). In both studies, SIPA1 polymorphisms were not related to overall mortality (per allele hazard ratios, 95% CI: 1.0,0.88-1.17; 0.90, 0.72-1.11; 1.0,0.90-1.21, respectively). Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Gaudet, Mia M AU - Hunter, Kent AU - Pharoah, Paul AU - Dunning, Alison M AU - Kristyiver AU - Lissowska, Jolanta AU - Sherman, Mark AU - Peplonska, Beata AU - Brinton, Louise A AU - Chanock, Stephen AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, gaudetm@mskcc.org Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1716 EP - 1720 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 7 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts KW - British Isles KW - Mortality KW - Exons KW - Prognosis KW - Survival KW - Genetic diversity KW - tumors KW - genetic diversity KW - Tumors KW - Cancer KW - Metastases KW - Single-nucleotide polymorphism KW - Poland KW - Breast cancer KW - survival KW - rodents KW - G 07870:Mammals KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20869990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Genetic+variation+in+SIPA1+in+relation+to+breast+cancer+risk+and+survival+after+breast+cancer+diagnosis&rft.au=Gaudet%2C+Mia+M%3BHunter%2C+Kent%3BPharoah%2C+Paul%3BDunning%2C+Alison+M%3BKristyiver%3BLissowska%2C+Jolanta%3BSherman%2C+Mark%3BPeplonska%2C+Beata%3BBrinton%2C+Louise+A%3BChanock%2C+Stephen%3BGarcia-Closas%2C+Montserrat&rft.aulast=Gaudet&rft.aufirst=Mia&rft.date=2009-04-01&rft.volume=124&rft.issue=7&rft.spage=1716&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23919 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Metastases; Mortality; Exons; Single-nucleotide polymorphism; Prognosis; Genetic diversity; Survival; Breast cancer; Tumors; genetic diversity; tumors; survival; rodents; Cancer; British Isles; Poland DO - http://dx.doi.org/10.1002/ijc.23919 ER - TY - JOUR T1 - Synthesis, characterization, and immunogenicity in mice of Shigella sonnei O-specific oligosaccharide-core-protein conjugates AN - 20799519; 10915672 AB - Shigellosis, an enteric disease, is on the World Health Organization's priority prevention list. In one study, the Shigella sonnei O-specific polysaccharide (O-SP)-protein conjugate showed 72% protection against disease in Israeli army recruits exposed to high rates (8-14%) of infection. The protection was related to vaccine-induced IgG anti-O-SP levels. Synthetic oligosaccharides of Shigella dysenteriae type 1, bound by their reducing ends to a carrier protein ('sun--type configuration), induced significantly higher antibody levels than the native O-SP bound to protein by multiple-point attachments ('lattice--type configuration). Attempts to synthesize the S. sonnei O-SP based oligosaccharides were not successful. Here, we describe the isolation, characterization, and conjugation of low-molecular-mass O-SP-core (O-SPC) fragments. The O-SPC fragments were bound by their reducing ends similar to the preparation of the synthetic S. dysenteriae type 1 conjugates. The O-SPC conjugates used oxime linkages between the terminal Kdo residues at the reducing ends of the S. sonnei saccharides and aminooxy linkers bound to BSA or a recombinant diphtheria toxin. The coupling reaction was carried out at a neutral pH and room temperature. IgG antibody levels induced in young outbred mice by the S. sonnei O- SPC conjugates were significantly higher then those elicited by the O-SP conjugates. Accordingly, we propose to evaluate clinically these conjugates. JF - Proceedings of the National Academy of Sciences, USA AU - Robbins, John B AU - Kubler-Kielb, Joanna AU - Vinogradov, Evguenii AU - Mocca, Christopher AU - Pozsgay, Vince AU - Shiloach, Joseph AU - Schneerson, Rachel AD - National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA, robbinsjo@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 7974 EP - 7978 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 19 SN - 0027-8424, 0027-8424 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology KW - lipopolysaccharide KW - glycoconjugate KW - vaccine KW - Kdo KW - IgG KW - Temperature effects KW - Conjugation KW - oligosaccharides KW - Organizations KW - Toxicants KW - Recruitment KW - Infection KW - Polysaccharides KW - Diphtheria toxin KW - Shigella dysenteriae KW - Saccharides KW - Recombinants KW - Antibodies KW - Shigella sonnei KW - Immunogenicity KW - Shigellosis KW - oximes KW - Immunoglobulin G KW - Vaccines KW - pH effects KW - Q1 08484:Species interactions: parasites and diseases KW - J 02350:Immunology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20799519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Synthesis%2C+characterization%2C+and+immunogenicity+in+mice+of+Shigella+sonnei+O-specific+oligosaccharide-core-protein+conjugates&rft.au=Robbins%2C+John+B%3BKubler-Kielb%2C+Joanna%3BVinogradov%2C+Evguenii%3BMocca%2C+Christopher%3BPozsgay%2C+Vince%3BShiloach%2C+Joseph%3BSchneerson%2C+Rachel&rft.aulast=Robbins&rft.aufirst=John&rft.date=2009-04-01&rft.volume=106&rft.issue=19&rft.spage=7974&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0900891106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Recombinants; Conjugation; Antibodies; Toxicants; Organizations; Recruitment; Polysaccharides; Saccharides; Temperature effects; oligosaccharides; Shigellosis; Immunogenicity; oximes; Immunoglobulin G; Vaccines; Infection; pH effects; Diphtheria toxin; Shigella sonnei; Shigella dysenteriae DO - http://dx.doi.org/10.1073/pnas.0900891106 ER - TY - JOUR T1 - PapR peptide maturation: role of the NprB protease in Bacillus cereus 569 PlcR/PapR global gene regulation AN - 20740275; 9257487 AB - AbstractThe global transcriptional regulator PlcR controls gene expression in Bacillus cereus and Bacillus thuringiensis. Activity of PlcR is regulated by PapR, the product of an ORF located immediately downstream of plcR. To be active in B. cereus, PapR must be secreted and then processed to the mature peptide by an unknown protease. This peptide is transported by an oligopeptide permease into the cell, where it activates PlcR. In this study, we show that the neutral protease B (NprB) secreted by B. cereus 569 is required for extracellular PapR maturation. Purified recombinant NprB processed the synthetic PapR propeptide to produce a set of peptides derived from the C-terminal domain of PapR. Supplementation of growth media with synthetic PapR-derived C-terminal 5-, 7-, 8- and 27-amino acid (aa) peptides caused activation of intracellular PlcR in a PapR-deficient strain of B. cereus 569 while only the 5- and 7-aa peptides activated PlcR in a nprB mutant. The maximum activity was found for the 7-mer peptide. However, even the 7-mer peptide could not activate PlcR with a C-terminal truncation of as few as 6aa. This indicates that interactions of the C-terminal regions of both PlcR and PapR are important in transcriptional activation of the B. cereus 569 PlcR regulon. JF - FEMS Immunology and Medical Microbiology AU - Pomerantsev, Andrei P AU - Pomerantseva, Olga M AU - Camp, Andrew S AU - Mukkamala, Radhika AU - Goldman, Stanley AU - Leppla, Stephen H AD - 1Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; and Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 361 EP - 377 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 55 IS - 3 SN - 0928-8244, 0928-8244 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Bacillus cereus KW - Bacillus anthracis KW - PlcR/PapR regulation KW - quorum sensing KW - protease KW - peptide KW - Bacillus thuringiensis KW - Phospholipase C KW - Gene regulation KW - oligopeptide permease KW - Transcription activation KW - Open reading frames KW - Supplementation KW - J 02320:Cell Biology KW - N 14830:RNA KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20740275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Immunology+and+Medical+Microbiology&rft.atitle=PapR+peptide+maturation%3A+role+of+the+NprB+protease+in+Bacillus+cereus+569+PlcR%2FPapR+global+gene+regulation&rft.au=Pomerantsev%2C+Andrei+P%3BPomerantseva%2C+Olga+M%3BCamp%2C+Andrew+S%3BMukkamala%2C+Radhika%3BGoldman%2C+Stanley%3BLeppla%2C+Stephen+H&rft.aulast=Pomerantsev&rft.aufirst=Andrei&rft.date=2009-04-01&rft.volume=55&rft.issue=3&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=FEMS+Immunology+and+Medical+Microbiology&rft.issn=09288244&rft_id=info:doi/10.1111%2Fj.1574-695X.2008.00521.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene regulation; Phospholipase C; oligopeptide permease; Supplementation; Open reading frames; Transcription activation; Bacillus thuringiensis; Bacillus cereus DO - http://dx.doi.org/10.1111/j.1574-695X.2008.00521.x ER - TY - JOUR T1 - Physical activity and breast cancer risk among pre- and postmenopausal women in the U.S. Radiologic Technologists cohort AN - 20738868; 9134756 AB - To clarify aspects of the association between physical activity and breast cancer, such as activity intensity required, and possible effect modification by factors such as menopausal hormone therapy (MHT) use. We prospectively examined physical activity in relation to breast cancer risk among 45,631 women participating in the U.S. Radiologic Technologists cohort. Participants provided information at baseline regarding hours spent per week engaging in strenuous activity, walking/hiking for exercise, and walking at home or work. We estimated multivariable relative risks (RR) and 95% confidence intervals (CI) of breast cancer using Cox regression. We identified 864 incident-invasive breast cancers. Greatest risk reduction was observed among women who reported walking/hiking for exercise 10 or more hours per week (RR, 0.57; 95% CI, 0.34-0.95) compared with those reporting no walking/hiking. The association between walking/hiking for exercise and breast cancer was modified by MHT use (p for interaction = 0.039). Postmenopausal women who never used MHT had reduced risks of breast cancer associated with physical activity whereas no relation was observed among ever users of MHT. Our study suggests moderate intensity physical activity, such as walking, may protect against breast cancer. Further, the relation between physical activity and breast cancer may be modified by MHT use. JF - Cancer Causes & Control AU - Howard, Regan A AU - Leitzmann, Michael F AU - Linet, Martha S AU - Freedman, DMichal AD - Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, NIH, DHHS, Executive Plaza South, Suite 7036, Bethesda, MD, 20892, USA, freedmam@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 323 EP - 333 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 20 IS - 3 SN - 0957-5243, 0957-5243 KW - Physical Education Index; Risk Abstracts KW - Home KW - post-menopause KW - Women KW - Walking KW - Work KW - Breasts KW - Exercise KW - Hormones KW - hiking KW - Cancer KW - risk reduction KW - USA KW - Exercise (intensity) KW - Breast cancer KW - Females KW - physical activity KW - Hiking KW - PE 090:Sports Medicine & Exercise Sport Science KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20738868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Physical+activity+and+breast+cancer+risk+among+pre-+and+postmenopausal+women+in+the+U.S.+Radiologic+Technologists+cohort&rft.au=Howard%2C+Regan+A%3BLeitzmann%2C+Michael+F%3BLinet%2C+Martha+S%3BFreedman%2C+DMichal&rft.aulast=Howard&rft.aufirst=Regan&rft.date=2009-04-01&rft.volume=20&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-008-9246-2 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Home; Exercise (intensity); Women; Work; Walking; Breasts; Exercise; Hiking; Cancer; risk reduction; post-menopause; Breast cancer; Females; physical activity; Hormones; hiking; USA DO - http://dx.doi.org/10.1007/s10552-008-9246-2 ER - TY - JOUR T1 - Identification of Pregnane X Receptor Ligands Using Time-Resolved Fluorescence Resonance Energy Transfer and Quantitative High-Throughput Screening AN - 20685426; 10193193 AB - The human pregnane X nuclear receptor (PXR) is a xenobiotic-regulated receptor that is activated by a range of diverse chemicals, including antibiotics, antifungals, glucocorticoids, and herbal extracts. PXR has been characterized as an important receptor in the metabolism of xenobiotics due to induction of cytochrome P450 isozymes and activation by a large number of prescribed medications. Developing methodologies that can efficiently detect PXR ligands will be clinically beneficial to avoid potential drug-drug interactions. To facilitate the identification of PXR ligands, a time-resolved fluorescence resonance energy transfer (TR-FRET) assay was miniaturized to a 1,536-well microtiter plate format to employ quantitative high-throughput screening (qHTS). The optimized 1,536-well TR-FRET assay showed Z'-factors of greater than or equal to 0.5. Seven- to 15-point concentration-response curves (CRCs) were generated for 8,280 compounds using both terbium and fluorescein emission data, resulting in the generation of 241,664 data points. The qHTS method allowed us to retrospectively examine single concentration screening datasets to assess the sensitivity and selectivity of the PXR assay at different compound screening concentrations. Furthermore, nonspecific assay artifacts such as concentration-based quenching of the terbium signal and compound fluorescence were identified through the examination of CRCs for specific emission channels. The CRC information was also used to define chemotypes associated with PXR ligands. This study demonstrates the feasibility of profiling thousands of compounds against PXR using the TR-FRET assay in a high-throughput format. JF - Assay and Drug Development Technologies AU - Shukla, S J AU - Nguyen, D-T AU - MacArthur, R AU - Simeonov, A AU - Frazee, W J AU - Hallis, T M AU - Marks, B D AU - Singh, U AU - Eliason, H C AU - Printen, J AU - Austin, C P AU - Inglese, J AU - Auld, D S AD - NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892-3370, USA, dauld@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 143 EP - 158 VL - 7 IS - 2 SN - 1540-658X, 1540-658X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Nuclear receptors KW - fluorescence resonance energy transfer KW - Antibiotics KW - Drug development KW - Xenobiotics KW - Glucocorticoids KW - fluorescein KW - Isoenzymes KW - high-throughput screening KW - pregnane X receptors KW - Cytochrome P450 KW - Metabolism KW - K 03320:Cell Biology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20685426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=Identification+of+Pregnane+X+Receptor+Ligands+Using+Time-Resolved+Fluorescence+Resonance+Energy+Transfer+and+Quantitative+High-Throughput+Screening&rft.au=Shukla%2C+S+J%3BNguyen%2C+D-T%3BMacArthur%2C+R%3BSimeonov%2C+A%3BFrazee%2C+W+J%3BHallis%2C+T+M%3BMarks%2C+B+D%3BSingh%2C+U%3BEliason%2C+H+C%3BPrinten%2C+J%3BAustin%2C+C+P%3BInglese%2C+J%3BAuld%2C+D+S&rft.aulast=Shukla&rft.aufirst=S&rft.date=2009-04-01&rft.volume=7&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/10.1089%2Fadt.2009.193 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Nuclear receptors; fluorescence resonance energy transfer; Drug development; Antibiotics; Xenobiotics; Glucocorticoids; fluorescein; Isoenzymes; high-throughput screening; Cytochrome P450; pregnane X receptors; Metabolism DO - http://dx.doi.org/10.1089/adt.2009.193 ER - TY - JOUR T1 - Cancer patterns in nasopharyngeal carcinoma multiplex families in Taiwan AN - 20626572; 9356232 AB - Genetic and environmental factors have been implicated in the etiology of nasopharyngeal carcinoma (NPC), a tumor known to be closely associated with Epstein-Barr virus (EBV) infection. Studies have reported familial aggregation of NPC and have suggested the possible aggregation of NPC and other cancers. We evaluated familial aggregation of cancer in 358 high-risk families with two or more NPC cases enrolled in a NPC genetics study in Taiwan. Participants were linked to the Taiwan National Cancer Registry to identify incident cancers diagnosed after study enrollment (started in 1996) and before December 31, 2005, or death. In total, 2,870 individuals from the NPC Multiplex Family Study contributed 15,151 person-years over an average of 5.3 years of follow-up. One hundred ten incident cancers were identified. Multiple-primary standardized incidence ratios (MP-SIRs) were computed to evaluate overall cancer risk associated with infectious agents and with other tumors. The overall MP-SIR was 1.3 (95% CI: 1.1-1.6), which was largely explained by an excess in NPC (MP-SIR = 15; 95% CI: 10-23). Exclusion of incident NPC diagnoses led to an overall MP-SIR of 1.0 (95% CI: 0.83-1.3). Similarly, the observed excess risk of cancers associated with infectious agents (MP-SIR = 2.0; 95% CI: 1.5-2.6) was driven by the excess in NPC; exclusion of NPC cases led to a reduced MP-SIR that did not differ from 1.0. Analysis of the largest NPC multiplex family study to date confirms the presence of coaggregation of NPC within families in Taiwan but does not provide evidence for a broader familial syndrome involving NPC and other tumors. JF - International Journal of Cancer AU - Yu, Kelly J AU - Hsu, Wan-Lun AU - Chiang, Chun-Ju AU - Cheng, Yu-Juen AU - Pfeiffer, Ruth M AU - Diehl, Scott R AU - Goldstein, Alisa M AU - Gravitt, Patti E AU - Chen, Chien-Jen AU - Hildesheim, Allan AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, yuke@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1622 EP - 1625 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 7 SN - 0020-7136, 0020-7136 KW - Virology & AIDS Abstracts; Risk Abstracts KW - environmental factors KW - Mortality KW - Taiwan KW - Etiology KW - tumors KW - Tumors KW - Infection KW - Environmental factors KW - Cancer KW - Family studies KW - Epstein-Barr virus KW - Nasopharyngeal carcinoma KW - Risk factors KW - infection KW - Risk groups KW - Standards KW - R2 23060:Medical and environmental health KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20626572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Cancer+patterns+in+nasopharyngeal+carcinoma+multiplex+families+in+Taiwan&rft.au=Yu%2C+Kelly+J%3BHsu%2C+Wan-Lun%3BChiang%2C+Chun-Ju%3BCheng%2C+Yu-Juen%3BPfeiffer%2C+Ruth+M%3BDiehl%2C+Scott+R%3BGoldstein%2C+Alisa+M%3BGravitt%2C+Patti+E%3BChen%2C+Chien-Jen%3BHildesheim%2C+Allan&rft.aulast=Yu&rft.aufirst=Kelly&rft.date=2009-04-01&rft.volume=124&rft.issue=7&rft.spage=1622&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24051 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Etiology; Nasopharyngeal carcinoma; Risk factors; Risk groups; Tumors; Infection; Environmental factors; Family studies; Mortality; environmental factors; infection; Standards; tumors; Cancer; Epstein-Barr virus; Taiwan DO - http://dx.doi.org/10.1002/ijc.24051 ER - TY - JOUR T1 - Geometric Aspects of Biological Sequence Comparison AN - 20607331; 9313642 AB - We introduce a geometric framework suitable for studying the relationships among biological sequences. In contrast to previous works, our formulation allows asymmetric distances (quasi-metrics), originating from uneven weighting of strings, which may induce non-trivial partial orders on sets of biosequences. The distances considered are more general than traditional generalized string edit distances. In particular, our framework enables non-trivial conversion between sequence similarities, both local and global, and distances. Our constructions apply to a wide class of scoring schemes and require much less restrictive gap penalties than the ones regularly used. Numerous examples are provided to illustrate the concepts introduced and their potential applications. JF - Journal of Computational Biology AU - Stojmirovic, A AU - Yu, Y-K AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA, yyu@ncbi.nlm.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 579 EP - 610 VL - 16 IS - 4 SN - 1066-5277, 1066-5277 KW - Biotechnology and Bioengineering Abstracts KW - Computer applications KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20607331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Biology&rft.atitle=Geometric+Aspects+of+Biological+Sequence+Comparison&rft.au=Stojmirovic%2C+A%3BYu%2C+Y-K&rft.aulast=Stojmirovic&rft.aufirst=A&rft.date=2009-04-01&rft.volume=16&rft.issue=4&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Biology&rft.issn=10665277&rft_id=info:doi/10.1089%2Fcmb.2008.0100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Computer applications DO - http://dx.doi.org/10.1089/cmb.2008.0100 ER - TY - JOUR T1 - Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family AN - 20596292; 9300847 AB - DNA single-strand breaks containing 3'-blocking groups are generated from attack of the sugar backbone by reactive oxygen species or after base excision by DNA glycosylase/apurinic/apyrimidinic (AP) lyases. In human cells, APE1 excises sugar fragments that block the 3'-ends thus facilitating DNA repair synthesis. In Leishmania major, the causal agent of leishmaniasis, the APE1 homolog is the class II AP endonuclease LMAP. Expression of LMAP but not of APE1 reverts the hypersensitivity of a xth nfo repair-deficient Escherichia coli strain to the oxidative compound hydrogen peroxide (H2O2). To identify the residues specifically involved in the repair of oxidative DNA damage, we generated random mutations in the ape1 gene and selected those variants that conferred protection against H2O2. Among the resistant clones, we isolated a mutant in the nuclease domain of APE1 (D70A) with an increased capacity to remove 3'-blocking ends in vitro. D70 of APE1 aligns with A138 of LMAP and mutation of the latter to aspartate significantly reduces its 3'-phosphodiesterase activity. Kinetic analysis shows a novel role of residue D70 in the excision rate of 3'-blocking ends. The functional and structural differences between the parasite and human enzymes probably reflect a divergent molecular evolution of their DNA repair responses to oxidative damage. JF - Nucleic Acids Research AU - Castillo-Acosta, Victor M AU - Ruiz-Perez, Luis M AU - Yang, Wei AU - Gonzalez-Pacanowska, Dolores AU - Vidal, Antonio E AD - 1 Instituto de Parasitologia y Biomedicina Lopez-Neyra, Consejo Superior de Investigaciones Cientificas, Avda. del Conocimiento s/n, 18100 Armilla (Granada), Spain and 2 Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA, avidal@ipb.csic.es Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1829 EP - 1842 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 37 IS - 6 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Leishmaniasis KW - Parasites KW - Sugar KW - molecular evolution KW - DNA glycosylase KW - Enzymes KW - Nuclease KW - DNA repair KW - DNA damage KW - Hypersensitivity KW - Reactive oxygen species KW - Structure-function relationships KW - Hydrogen peroxide KW - Kinetics KW - Escherichia coli KW - AP endonuclease KW - Endonuclease KW - Leishmania major KW - Mutation KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20596292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Identification+of+a+residue+critical+for+the+excision+of+3%27-blocking+ends+in+apurinic%2Fapyrimidinic+endonucleases+of+the+Xth+family&rft.au=Castillo-Acosta%2C+Victor+M%3BRuiz-Perez%2C+Luis+M%3BYang%2C+Wei%3BGonzalez-Pacanowska%2C+Dolores%3BVidal%2C+Antonio+E&rft.aulast=Castillo-Acosta&rft.aufirst=Victor&rft.date=2009-04-01&rft.volume=37&rft.issue=6&rft.spage=1829&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkp021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Leishmaniasis; Sugar; Parasites; molecular evolution; DNA glycosylase; Nuclease; Enzymes; DNA repair; DNA damage; Hypersensitivity; Reactive oxygen species; Hydrogen peroxide; Structure-function relationships; Kinetics; AP endonuclease; Endonuclease; Mutation; Escherichia coli; Leishmania major DO - http://dx.doi.org/10.1093/nar/gkp021 ER - TY - JOUR T1 - Brugia malayi Excreted/Secreted Proteins at the Host/Parasite Interface: Stage- and Gender-Specific Proteomic Profiling AN - 20592258; 9304711 AB - Relatively little is known about the filarial proteins that interact with the human host. Although the filarial genome has recently been completed, protein profiles have been limited to only a few recombinants or purified proteins of interest. Here, we describe a large-scale proteomic analysis using microcapillary reverse-phase liquid chromatography-tandem-mass spectrometry to identify the excretory-secretory (ES) products of the L3, L3 to L4 molting ES, adult male, adult female, and microfilarial stages of the filarial parasite Brugia malayi. The analysis of the ES products from adult male, adult female, microfilariae (Mf), L3, and molting L3 larvae identified 852 proteins. Annotation suggests that the functional and component distribution was very similar across each of the stages studied; however, the Mf contributed a higher proportion to the total number of identified proteins than the other stages. Of the 852 proteins identified in the ES, only 229 had previous confirmatory expressed sequence tags (ESTs) in the available databases. Moreover, this analysis was able to confirm the presence of 274 ahypotheticala proteins inferred from gene prediction algorithms applied to the B. malayi (Bm) genome. Not surprisingly, the majority (160/274) of these ahypotheticala proteins were predicted to be secreted by Signal IP and/or SecretomeP 2.0 analysis. Of major interest is the abundance of previously characterized immunomodulatory proteins such as ES-62 (leucyl aminopeptidase), MIF-1, SERPIN, glutathione peroxidase, and galectin in the ES of microfilariae (and Mf-containing adult females) compared to the adult males. In addition, searching the ES protein spectra against the Wolbachia database resulted in the identification of 90 Wolbachia-specific proteins, most of which were metabolic enzymes that have not been shown to be immunogenic. This proteomic analysis extends our knowledge of the ES and provides insight into the hostaparasite interaction. Author Summary Human lymphatic filariasis caused by the nematode parasites Brugia malayi and Wuchereria bancrofti are a major cause of concern in tropical countries. Studies over several decades have identified various proteins of these parasites that have highlighted their role in hostaparasite interactions and possible chemotherapeutic and prophylactic interventions. The availability of the parasite genome facilitates the identification of all of the proteins of the parasite that could interact with the host. In this study, we have attempted to identify the excretory-secretory proteins of the various stages of the parasite that could be maintained in vitro for a limited period utilizing a high-throughput proteomics approach. We observe and report that the parasites expend resources to secrete out various molecules that they utilize to evade the host immune system and modulate its responses. Further, this study also provides information on the predicted hypothetical proteins to be bonafide proteins and thus a catalogue of the excretory-secretory proteins towards a better understanding of the hostaparasite interactions. JF - PLoS Neglected Tropical Diseases AU - Bennuru, Sasisekhar AU - Semnani, Roshanak AU - Meng, Zhaojing AU - Ribeiro, Jose MC AU - Veenstra, Timothy D AU - Nutman, Thomas B AU - Ghedin, Elodie AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 3 IS - 4 SN - 1935-2727, 1935-2727 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Genomes KW - Parasites KW - Wolbachia KW - Immune system KW - Larvae KW - Algorithms KW - Filariasis KW - Leucyl aminopeptidase KW - Enzymes KW - Molting KW - expressed sequence tags KW - Immunomodulation KW - Spectrometry KW - Recombinants KW - Databases KW - Wuchereria bancrofti KW - ES-62 protein KW - Brugia malayi KW - Immunogenicity KW - Glutathione peroxidase KW - proteomics KW - serpins KW - Nematoda KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20592258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Brugia+malayi+Excreted%2FSecreted+Proteins+at+the+Host%2FParasite+Interface%3A+Stage-+and+Gender-Specific+Proteomic+Profiling&rft.au=Bennuru%2C+Sasisekhar%3BSemnani%2C+Roshanak%3BMeng%2C+Zhaojing%3BRibeiro%2C+Jose+MC%3BVeenstra%2C+Timothy+D%3BNutman%2C+Thomas+B%3BGhedin%2C+Elodie&rft.aulast=Bennuru&rft.aufirst=Sasisekhar&rft.date=2009-04-01&rft.volume=3&rft.issue=4&rft.spage=e410&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0000410 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Parasites; Immune system; Filariasis; Algorithms; Larvae; Enzymes; Leucyl aminopeptidase; Molting; Immunomodulation; expressed sequence tags; Spectrometry; Recombinants; Databases; ES-62 protein; Glutathione peroxidase; Immunogenicity; proteomics; serpins; Wuchereria bancrofti; Wolbachia; Brugia malayi; Nematoda DO - http://dx.doi.org/10.1371/journal.pntd.0000410 ER - TY - JOUR T1 - The Tachikawa cohort of motor vehicle accident study investigating psychological distress: design, methods and cohort profiles AN - 20591219; 9297392 AB - Background: The Tachikawa cohort of motor vehicle accident (TCOM) Study has been carried out in Tokyo since 2004. This study examined the association of medical and psychosocial variables evaluated shortly after admission to the acute critical care center with long-term psychiatric morbidity risk in patients with accidental injuries. Methods: Between May 2004 and January 2008, patients with accidental injury consecutively admitted were recruited to the TCOM Study. Psychiatric morbidity as a primary endpoint was measured using a structured clinical interview at 1, 6, 18 and 36 months after involvement in a motor vehicle accident (MVA). The baseline investigation consisted of self-administered questionnaires concerning acute psychological responses and personality. Medical information was obtained from patients' medical charts. Various socio-demographic data, health-related habits and psychosocial factors were assessed by interview. To examine potential biomarkers of psychological distress, blood samples were collected. Results: Out of 344 patients who were asked to participate in this study, 300 (87%) patients with MVA-related injury were enrolled. Corresponding rates for the questionnaires on psychological responses and blood sampling were 98-99 and 79%, respectively. The cohort sample was composed of 78% men; the median age was 34 years; and 45% of the participants were motorcycle drivers. Conclusions: The TCOM Study should prove useful for researchers examining the association between bio-psychosocial variables and psychological distress and may contribute to the formation of a framework for providing care for patients with MVA-related injury. JF - Social Psychiatry and Psychiatric Epidemiology AU - Matsuoka, Yutaka AU - Nishi, Daisuke AU - Nakajima, Satomi AU - Yonemoto, Naohiro AU - Hashimoto, Kenji AU - Noguchi, Hiroko AU - Homma, Masato AU - Otomo, Yasuhiro AU - Kim, Yoshiharu AD - Dept. of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi Kodaira, Tokyo, 187-8553, Japan, yutaka@ncnp.go.jp Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 333 EP - 340 PB - Springer-Verlag (New York), P.O. Box 2485 VL - 44 IS - 4 SN - 0933-7954, 0933-7954 KW - Risk Abstracts KW - Bioindicators KW - Accidents KW - Age KW - Injuries KW - Psychology KW - Motor vehicles KW - Japan, Honshu, Tokyo Prefect., Tokyo KW - personality KW - Motorcycles KW - Morbidity KW - Design KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20591219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.atitle=The+Tachikawa+cohort+of+motor+vehicle+accident+study+investigating+psychological+distress%3A+design%2C+methods+and+cohort+profiles&rft.au=Matsuoka%2C+Yutaka%3BNishi%2C+Daisuke%3BNakajima%2C+Satomi%3BYonemoto%2C+Naohiro%3BHashimoto%2C+Kenji%3BNoguchi%2C+Hiroko%3BHomma%2C+Masato%3BOtomo%2C+Yasuhiro%3BKim%2C+Yoshiharu&rft.aulast=Matsuoka&rft.aufirst=Yutaka&rft.date=2009-04-01&rft.volume=44&rft.issue=4&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Social+Psychiatry+and+Psychiatric+Epidemiology&rft.issn=09337954&rft_id=info:doi/10.1007%2Fs00127-008-0438-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bioindicators; Age; Accidents; Injuries; Psychology; Motor vehicles; Motorcycles; personality; Morbidity; Design; Japan, Honshu, Tokyo Prefect., Tokyo DO - http://dx.doi.org/10.1007/s00127-008-0438-6 ER - TY - JOUR T1 - Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission AN - 20588950; 9292688 AB - In this double-blind, placebo-controlled study, we examined the effects of subanaesthetic doses of ketamine (an NMDA glutamate receptor antagonist) and thiopental (a GABA-A receptor agonist) on the event-related potential (ERP) correlates of deviant stimulus processing in 24 healthy adults. Participants completed three separate pharmacological challenge sessions (ketamine, thiopental, saline) in a counterbalanced order. EEG data were recorded both before and during each challenge while participants performed a visual 'oddball' task consisting of infrequent 'target' and 'novel' stimuli intermixed with frequent 'standard' stimuli. We examined drug effects on the amplitude and latency of the P300 (P3) component of the ERP elicited by target (P3b) and novel stimuli (P3a), as well as the N200 (N2) component elicited by both target and novel stimuli, and the N100 (N1) elicited by standard stimuli. Relative to placebo, both drugs reduced the amplitude of parietal P3b. While both drugs reduced parietal P3a and Novelty N2, ketamine also shortened P3a latency, reduced Novelty N2 amplitude more than thiopental, and increased frontal P3a amplitude relative to placebo. Overall, the data suggest that both the GABA-A and NMDA receptor systems modulate P3b and P3a. NMDA antagonism appears to lead to more varied effects on the neural correlates of novelty processing. JF - International Journal of Neuropsychopharmacology AU - Watson, Todd D AU - Petrakis, Ismene L AU - Edgecombe, Javon AU - Perrino, Albert AU - Krystal, John H AU - Mathalon, Daniel H AD - NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA, toddw@lclark.edu Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 357 EP - 370 PB - Cambridge University Press VL - 12 IS - 3 SN - 1461-1457, 1461-1457 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Novelty KW - N-Methyl-D-aspartic acid receptors KW - Data processing KW - gamma -Aminobutyric acid KW - Event-related potentials KW - Glutamic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Auditory evoked potentials KW - Visual evoked potentials KW - thiopental KW - Neurotransmission KW - Information processing KW - gamma -Aminobutyric acid A receptors KW - Ketamine KW - EEG KW - Drugs KW - N3 11001:Behavioral and Cognitive Neuroscience KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Neuropsychopharmacology&rft.atitle=Modulation+of+the+cortical+processing+of+novel+and+target+stimuli+by+drugs+affecting+glutamate+and+GABA+neurotransmission&rft.au=Watson%2C+Todd+D%3BPetrakis%2C+Ismene+L%3BEdgecombe%2C+Javon%3BPerrino%2C+Albert%3BKrystal%2C+John+H%3BMathalon%2C+Daniel+H&rft.aulast=Watson&rft.aufirst=Todd&rft.date=2009-04-01&rft.volume=12&rft.issue=3&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Neuropsychopharmacology&rft.issn=14611457&rft_id=info:doi/10.1017%2FS1461145708009334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Novelty; N-Methyl-D-aspartic acid receptors; Data processing; gamma -Aminobutyric acid; Event-related potentials; Glutamic acid receptors; Glutamic acid receptors (ionotropic); Visual evoked potentials; Auditory evoked potentials; Neurotransmission; thiopental; Information processing; gamma -Aminobutyric acid A receptors; Ketamine; EEG; Drugs DO - http://dx.doi.org/10.1017/S1461145708009334 ER - TY - JOUR T1 - Opinion: The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research AN - 20567082; 9283846 AB - Cyclooxygenases (COX-1 and COX-2) are key enzymes in the conversion of arachidonic acid to prostaglandins and other lipid mediators. Because it can be induced by inflammatory stimuli, COX-2 has been classically considered as the most appropriate target for anti-inflammatory drugs. However, recent data indicate that COX-2 can mediate neuroprotection and that COX-1 is a major player in the neuroinflammatory process. We discuss the specific contributions of COX-1 and COX-2 in various neurodegenerative diseases and in models of neuroinflammation. We suggest that, owing to its predominant localization in microglia, COX-1 might be the major player in neuroinflammation, whereas COX-2, which is localized in neurons, might have a major role in models in which the neurons are directly challenged. Overall, the benefit of using COX-2 inhibitors should be carefully evaluated and COX-1 preferential inhibitors should be further investigated as a potential therapeutic approach in neurodegenerative diseases with an inflammatory component. JF - Trends in Pharmacological Sciences AU - Choi, Sang-Ho AU - Aid, Saba AU - Bosetti, Francesca AD - Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA, frances@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 174 EP - 181 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 30 IS - 4 SN - 0165-6147, 0165-6147 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Cyclooxygenase-2 KW - Translation KW - Data processing KW - Lipids KW - Prostaglandins KW - Enzymes KW - Arachidonic acid KW - Neuroprotection KW - Microglia KW - Inflammation KW - Cyclooxygenase-1 KW - Neurodegenerative diseases KW - Inflammatory diseases KW - Reviews KW - Neurons KW - Antiinflammatory agents KW - W 30940:Products KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20567082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Pharmacological+Sciences&rft.atitle=Opinion%3A+The+distinct+roles+of+cyclooxygenase-1+and+-2+in+neuroinflammation%3A+implications+for+translational+research&rft.au=Choi%2C+Sang-Ho%3BAid%2C+Saba%3BBosetti%2C+Francesca&rft.aulast=Choi&rft.aufirst=Sang-Ho&rft.date=2009-04-01&rft.volume=30&rft.issue=4&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Trends+in+Pharmacological+Sciences&rft.issn=01656147&rft_id=info:doi/10.1016%2Fj.tips.2009.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Translation; Data processing; Lipids; Prostaglandins; Arachidonic acid; Enzymes; Neuroprotection; Microglia; Cyclooxygenase-1; Inflammation; Neurodegenerative diseases; Inflammatory diseases; Neurons; Reviews; Antiinflammatory agents DO - http://dx.doi.org/10.1016/j.tips.2009.01.002 ER - TY - JOUR T1 - Evaluation of 6-([ super(18)F]fluoroacetamido)-l-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain AN - 20557436; 9259241 AB - Introduction: Histone deacetylases (HDACs) are enzymes involved in epigenetic modifications that shift the balance toward chromatin condensation and silencing of gene expression. Here, we evaluate the utility of 6-([ super(18)F]fluoroacetamido)-l-hexanoicanilide ([ super(18)F]FAHA) for positron emission tomography imaging of HDAC activity in the baboon brain. For this purpose, we assessed its in vivo biodistribution, sensitivity to HDAC inhibition, metabolic stability and the distribution of the putative metabolite [ super(18)F]fluoroacetate ([ super(18)F]FAC). Methods: [ super(18)F]FAHA and its metabolite [ super(18)F]FAC were prepared, and their in vivo biodistribution and pharmacokinetics were determined in baboons. [ super(18)F]FAHA metabolism and its sensitivity to HDAC inhibition using suberanilohydroxamic acid (SAHA) were assessed in arterial plasma and by in vitro incubation studies. The chemical form of F-18 in rodent brain was assessed by ex vivo studies. Distribution volumes for [ super(18)F]FAHA in the brain were derived. Results: [ super(18)F]FAHA was rapidly metabolized to [ super(18)F]FAC, and both labeled compounds entered the brain. [ super(18)F]FAHA exhibited regional differences in brain uptake and kinetics. In contrast, [ super(18)F]FAC showed little variation in regional brain uptake and kinetics. A kinetic analysis that takes into account the uptake of peripherally produced [ super(18)F]FAC indicated that SAHA inhibited binding of [ super(18)F]FAHA in the baboon brain dose-dependently. In vitro studies demonstrated SAHA-sensitive metabolism of [ super(18)F]FAHA to [ super(18)F]FAC within the cell and diffusion of [ super(18)F]FAC out of the cell. All radioactivity in brain homogenate from rodents was [ super(18)F]FAC at 7 min postinjection of [ super(18)F]FAHA. Conclusion: The rapid metabolism of [ super(18)F]FAHA to [ super(18)F]FAC in the periphery complicates the quantitative analysis of HDAC in the brain. However, dose-dependent blocking studies with SAHA and kinetic modeling indicated that a specific interaction of [ super(18)F]FAHA in the brain was observed. Validating the nature of this interaction as HDAC specific will require additional studies. Published by Elsevier Inc. JF - Nuclear Medicine and Biology AU - Reid, A E AU - Hooker, J AU - Shumay, E AU - Logan, J AU - Shea, C AU - Kim, S W AU - Collins, S AU - Xu, Y AU - Volkow, N AU - Fowler, J S AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA, areid@bnl.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 247 EP - 258 VL - 36 IS - 3 SN - 0969-8051, 0969-8051 KW - Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Papio KW - Histone deacetylase KW - Neuroimaging KW - Chromatin KW - Brain KW - Enzymes KW - Metabolites KW - Pharmacokinetics KW - Gene expression KW - epigenetics KW - Kinetics KW - Positron emission tomography KW - Diffusion KW - Condensation KW - Radioactivity KW - Metabolism KW - W 30910:Imaging KW - N 14820:DNA Metabolism & Structure KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20557436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Medicine+and+Biology&rft.atitle=Evaluation+of+6-%28%5B+super%2818%29F%5Dfluoroacetamido%29-l-hexanoicanilide+for+PET+imaging+of+histone+deacetylase+in+the+baboon+brain&rft.au=Reid%2C+A+E%3BHooker%2C+J%3BShumay%2C+E%3BLogan%2C+J%3BShea%2C+C%3BKim%2C+S+W%3BCollins%2C+S%3BXu%2C+Y%3BVolkow%2C+N%3BFowler%2C+J+S&rft.aulast=Reid&rft.aufirst=A&rft.date=2009-04-01&rft.volume=36&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Nuclear+Medicine+and+Biology&rft.issn=09698051&rft_id=info:doi/10.1016%2Fj.nucmedbio.2008.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Neuroimaging; Chromatin; Brain; Enzymes; Metabolites; Pharmacokinetics; Gene expression; epigenetics; Kinetics; Positron emission tomography; Condensation; Diffusion; Radioactivity; Metabolism; Papio DO - http://dx.doi.org/10.1016/j.nucmedbio.2008.12.005 ER - TY - JOUR T1 - Simultaneous single neuron recording of O2 consumption, [Ca2+]i and mitochondrial membrane potential in glutamate toxicity AN - 20547601; 9255287 AB - AbstractIn order to determine the sequence of cellular processes in glutamate toxicity, we simultaneously recorded O2 consumption, cytosolic Ca2+ concentration ([Ca2+]i), and mitochondrial membrane potential (m psi ) in single cortical neurons. Oxygen consumption was measured using an amperometric self-referencing platinum electrode adjacent to neurons in which [Ca2+]i and m psi were monitored with Fluo-4 and TMRE+, respectively, using a spinning disk laser confocal microscope. Excitotoxic doses of glutamate caused an elevation of [Ca2+]i followed seconds afterwards by an increase in O2 consumption which reached a maximum level within 1-5min. A modest increase in m psi occurred during this time period, and then, shortly before maximal O2 consumption was reached, the m psi , as indicated by TMRE+ fluorescence, dissipated. Maximal O2 consumption lasted up to 5min and then declined together with m psi and ATP levels, while [Ca2+]i further increased. m psi and [Ca2+]i returned to baseline levels when neurons were treated with an NMDA receptor antagonist shortly after the [Ca2+]i increased. Our unprecedented spatial and time resolution revealed that this sequence of events is identical in all neurons, albeit with considerable variability in magnitude and kinetics of changes in O2 consumption, [Ca2+]i, and m psi . The data obtained using this new method are consistent with a model where Ca2+ influx causes ATP depletion, despite maximal mitochondrial respiration, minutes after glutamate receptor activation. JF - Journal of Neurochemistry AU - Gleichmann, Marc AU - Collis, Leon P AU - Smith, Peter JS AU - Mattson, Mark P AD - *Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Biomedical Research Center, Baltimore, Maryland, USA, mattsonm@grc.nia.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 644 EP - 655 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 109 IS - 2 SN - 0022-3042, 0022-3042 KW - Toxicology Abstracts; Calcium & Calcified Tissue Abstracts; CSA Neurosciences Abstracts KW - Oxygen consumption KW - N-Methyl-D-aspartic acid receptors KW - Fluorescence KW - Calcium KW - Data processing KW - Microscopes KW - ATP KW - Mitochondria KW - Toxicity KW - Glutamic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Calcium influx KW - Cortex KW - Neurons KW - Kinetics KW - Electrodes KW - Platinum KW - Lasers KW - Electron transport KW - Excitotoxicity KW - Membrane potential KW - X 24390:Radioactive Materials KW - T 2055:Laboratory Methods KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20547601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Simultaneous+single+neuron+recording+of+O2+consumption%2C+%5BCa2%2B%5Di+and+mitochondrial+membrane+potential+in+glutamate+toxicity&rft.au=Gleichmann%2C+Marc%3BCollis%2C+Leon+P%3BSmith%2C+Peter+JS%3BMattson%2C+Mark+P&rft.aulast=Gleichmann&rft.aufirst=Marc&rft.date=2009-04-01&rft.volume=109&rft.issue=2&rft.spage=644&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2009.05997.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Oxygen consumption; N-Methyl-D-aspartic acid receptors; Data processing; Calcium; Fluorescence; Microscopes; Mitochondria; ATP; Toxicity; Glutamic acid receptors; Glutamic acid receptors (ionotropic); Calcium influx; Cortex; Kinetics; Neurons; Electrodes; Platinum; Lasers; Electron transport; Excitotoxicity; Membrane potential DO - http://dx.doi.org/10.1111/j.1471-4159.2009.05997.x ER - TY - JOUR T1 - Production Assistance for Cellular Therapies (PACT): four-year experience from the United States National Heart, Lung, and Blood Institute (NHLBI) contract research program in cell and tissue therapies AN - 20546389; 9256258 AB - BACKGROUND: In 2002, the US National Heart, Lung, and Blood Institute (NHLBI) conducted a workshop to determine needs of the cell therapy community. A consensus emerged that improved access to cGMP facilities, regulatory assistance, and training would foster the advancement of cellular therapy.STUDY DESIGN AND METHODS: A 2003 NHLBI request for proposals resulted in four contracts being awarded to three cell-manufacturing facilities (Baylor College of Medicine, University of Minnesota, and University of Pittsburgh) and one administrative center (The EMMES Corporation). As a result, Production Assistance for Cellular Therapies (PACT) was formed.RESULTS: As of October 1, 2008, PACT has received 65 preliminary applications of which 45 have been approved for product manufacture. A variety of cell therapies are represented including T-regulatory cells, natural killer cells, adipose-derived stem cells, cardiac progenitor cells for cardiac disease, hematopoietic progenitor cells (HPCs) for central nervous system applications, cytotoxic T lymphocytes, and dendritic cells. A total of 169 products have been administered under 12 applications and 2 reagents were manufactured and delivered. Fourteen peer-reviewed publications and 15 abstracts have resulted from the PACT project to date. A cell therapy textbook is nearly complete. PACT technical projects have addressed assay development, rapid endotoxin testing, shipping of cell products, and CD34+ HPC isolation from low-volume marrow. Educational Web seminars and onsite training through workshops have been conducted.CONCLUSIONS: PACT is an active and successful cell therapy manufacturing resource in the United States, addressing research and training while forging relationships among academia, industry, and participating institutions. JF - Transfusion AU - Reed, William AU - Noga, Stephen J AU - Gee, Adrian P AU - Rooney, Cliona M AU - Wagner, John E AU - McCullough, Jeffrey AU - McKenna, David H AU - Whiteside, Theresa L AU - Donnenberg, Albert D AU - Baker, Acacia K AU - Lindblad, Robert W AU - Wagner, Elizabeth L AU - Mondoro, Traci Heath AD - From the Blood Systems Research Institute (BSRI), San Francisco, California; the Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; Sinai Hospital, Johns Hopkins University, Baltimore, Maryland; Baylor College of Medicine, Houston, Texas; University of Minnesota, Minneapolis, Minnesota; University of Pittsburgh, Pittsburgh, Pennsylvania; The EMMES Corporation, Rockville, Maryland; and the National Heart, Lung, and Blood Institute, Bethesda, Maryland. Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 786 EP - 796 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 49 IS - 4 SN - 0041-1132, 0041-1132 KW - Biotechnology and Bioengineering Abstracts KW - Endotoxins KW - Heart KW - Central nervous system KW - Conferences KW - Natural killer cells KW - CD34 antigen KW - Cyclic GMP KW - Dendritic cells KW - Blood KW - Stem cells KW - Cytotoxicity KW - Lung KW - Lymphocytes T KW - Hemopoiesis KW - Research programs KW - Heart diseases KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20546389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Production+Assistance+for+Cellular+Therapies+%28PACT%29%3A+four-year+experience+from+the+United+States+National+Heart%2C+Lung%2C+and+Blood+Institute+%28NHLBI%29+contract+research+program+in+cell+and+tissue+therapies&rft.au=Reed%2C+William%3BNoga%2C+Stephen+J%3BGee%2C+Adrian+P%3BRooney%2C+Cliona+M%3BWagner%2C+John+E%3BMcCullough%2C+Jeffrey%3BMcKenna%2C+David+H%3BWhiteside%2C+Theresa+L%3BDonnenberg%2C+Albert+D%3BBaker%2C+Acacia+K%3BLindblad%2C+Robert+W%3BWagner%2C+Elizabeth+L%3BMondoro%2C+Traci+Heath&rft.aulast=Reed&rft.aufirst=William&rft.date=2009-04-01&rft.volume=49&rft.issue=4&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2008.02027.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Endotoxins; Central nervous system; Conferences; Natural killer cells; CD34 antigen; Cyclic GMP; Blood; Dendritic cells; Cytotoxicity; Stem cells; Lung; Lymphocytes T; Hemopoiesis; Research programs; Heart diseases DO - http://dx.doi.org/10.1111/j.1537-2995.2008.02027.x ER - TY - JOUR T1 - Factors Associated with the Prevalence and Incidence of Herpes Simplex Virus Type 2 Infection among Men in Rakai, Uganda AN - 20536735; 9225179 AB - Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: JF - Journal of Infectious Diseases AU - Tobian, Aaron AR AU - Charvat, Blake AU - Ssempijja, Victor AU - Kigozi, Godfrey AU - Serwadda, David AU - Makumbi, Frederick AU - Iga, Boaz AU - Laeyendecker, Oliver AU - Riedesel, Melissa AU - Oliver, Amy AU - Chen, Michael Z AU - Reynolds, Steven J AU - Wawer, Maria J AU - Gray, Ronald H AU - Quinn, Thomas C AD - Departments of Pathology and Medicine, Johns Hopkins University School of Medicine, and Department of Population, Family, and Reproductive Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, and Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, atobian1@jhmi.edu Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 945 EP - 949 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 7 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - sexual behavior KW - Alcohol KW - males KW - Uganda KW - Herpes simplex virus 2 KW - Infection KW - Condoms KW - Education KW - Human immunodeficiency virus KW - Risk factors KW - Treponema pallidum KW - infection KW - condoms KW - alcohols KW - Africa KW - Sexual intercourse KW - Syphilis KW - syphilis KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20536735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Factors+Associated+with+the+Prevalence+and+Incidence+of+Herpes+Simplex+Virus+Type+2+Infection+among+Men+in+Rakai%2C+Uganda&rft.au=Tobian%2C+Aaron+AR%3BCharvat%2C+Blake%3BSsempijja%2C+Victor%3BKigozi%2C+Godfrey%3BSerwadda%2C+David%3BMakumbi%2C+Frederick%3BIga%2C+Boaz%3BLaeyendecker%2C+Oliver%3BRiedesel%2C+Melissa%3BOliver%2C+Amy%3BChen%2C+Michael+Z%3BReynolds%2C+Steven+J%3BWawer%2C+Maria+J%3BGray%2C+Ronald+H%3BQuinn%2C+Thomas+C&rft.aulast=Tobian&rft.aufirst=Aaron&rft.date=2009-04-01&rft.volume=199&rft.issue=7&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F597074 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Condoms; Risk factors; alcohols; Infection; Syphilis; Sexual intercourse; Alcohol; sexual behavior; Education; Human immunodeficiency virus; condoms; infection; males; syphilis; Treponema pallidum; Herpes simplex virus 2; Africa; Uganda DO - http://dx.doi.org/10.1086/597074 ER - TY - JOUR T1 - Early Changes in Hepatitis C Virus (HCV) Levels in Response to Peginterferon and Ribavirin Treatment in Patients with Chronic HCV Genotype 1 Infection AN - 20536524; 9225203 AB - Early changes in hepatitis C virus (HCV) RNA levels were assessed in a large cohort of African American and white patients with chronic hepatitis C due to HCV genotype 1 who underwent therapy with peginterferon alfa-2a and ribavirin in the Study of Viral Resistance to Antiviral Therapy of Hepatitis C (Virahep-C). Analyses were restricted to 341 patients who completed the first 28 days of therapy without dose modification. HCV RNA levels decreased in virtually all patients, but the amount of the change varied markedly. The overall 28-day decrease in HCV RNA levels was at least as predictive of a sustained virological response as the first- or second-phase viral kinetics responses. Factors associated with a smaller decrease in the HCV RNA level between baseline and day 28 included African American race, higher initial HCV RNA level, more severe hepatic fibrosis, and higher body weight. African American patients with similar 28-day decreases in viral levels as white patients were still less likely to achieve a sustained virological response. These results suggest that racial differences in the response to antiviral therapy are due to greater unresponsiveness to intracellular actions of interferon in African American individuals and that standard doses of peginterferon and ribavirin may be suboptimal for patients with higher body weights. Trial registration. ClinicalTrials.gov identifier: JF - Journal of Infectious Diseases AU - Hoofnagle, Jay H AU - Wahed, Abdus S AU - Brown, Robert S AU - Howell, Charles D AU - Belle, Steven H AU - Group, Virahep-C Study AD - Liver Disease Research Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, and Division of Hepatology, University of Maryland School of Medicine, Baltimore, Maryland, hoofnaglej@extra.niddk.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1112 EP - 1120 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 8 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Fibrosis KW - Ribavirin KW - RNA viruses KW - Genotypes KW - Disease resistance KW - Clinical trials KW - Interferon KW - Hepatitis C virus KW - Body weight KW - RNA KW - Kinetics KW - Chronic infection KW - RNA modification KW - Liver KW - Hepatitis C KW - Races KW - A 01340:Antibiotics & Antimicrobials KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20536524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Early+Changes+in+Hepatitis+C+Virus+%28HCV%29+Levels+in+Response+to+Peginterferon+and+Ribavirin+Treatment+in+Patients+with+Chronic+HCV+Genotype+1+Infection&rft.au=Hoofnagle%2C+Jay+H%3BWahed%2C+Abdus+S%3BBrown%2C+Robert+S%3BHowell%2C+Charles+D%3BBelle%2C+Steven+H%3BGroup%2C+Virahep-C+Study&rft.aulast=Hoofnagle&rft.aufirst=Jay&rft.date=2009-04-01&rft.volume=199&rft.issue=8&rft.spage=1112&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F597384 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Fibrosis; Ribavirin; RNA viruses; Disease resistance; Genotypes; Clinical trials; Interferon; RNA; Body weight; Kinetics; RNA modification; Chronic infection; Liver; Hepatitis C; Races; Hepatitis C virus DO - http://dx.doi.org/10.1086/597384 ER - TY - JOUR T1 - Effects of chronic caffeine exposure on adenosinergic modulation of the discriminative-stimulus effects of nicotine, methamphetamine, and cocaine in rats AN - 20513081; 9204733 AB - Rationale: Adenosine receptors are involved in cocaine and methamphetamine discrimination and exposure to caffeine can affect behavioral effects of nicotine in rats. Objectives: Here we investigated the relative involvement of adenosine A1 and A2A receptors in nicotine, cocaine, and methamphetamine discrimination, before and/or during chronic caffeine exposure. Materials and methods: The nonselective adenosine receptor antagonist caffeine, the A1-receptor antagonist cyclopentyltheophylline (CPT), and the A2A-receptor antagonist MSX-3 were evaluated in rats trained to discriminate 0.4 mg/kg nicotine from saline under a fixed-ratio schedule of food delivery. Effects of adenosine receptor antagonists were then compared in rats discriminating nicotine, methamphetamine, or cocaine from saline during chronic caffeine exposure in their drinking water. Results: Caffeine, CPT, and MSX-3 partially generalized to nicotine and shifted nicotine dose-response curves leftwards. During chronic caffeine exposure, however, all three ligands failed to generalize to nicotine and failed to shift nicotine dose-response curves. In previous experiments, CPT and MSX-3 partially generalized to methamphetamine and cocaine and shifted dose-response curves leftwards. In the present experiments, CPT neither generalized nor shifted dose-response curves for methamphetamine or cocaine during chronic caffeine exposure. However, MSX-3 partially generalized to both psychostimulants and shifted their dose-response curves leftwards. Caffeine partially generalized to cocaine, but not methamphetamine, and shifted both dose-response curves leftwards. Conclusions: Both adenosine A1 and A2A receptors are capable of modulating the discriminative-stimulus effects of nicotine. Chronic caffeine exposure produces complete tolerance to both A1- and A2A-mediated effects in nicotine-trained rats. In contrast, chronic caffeine exposure produces tolerance to adenosine A1-mediated, but not A2A-mediated, effects in methamphetamine- and cocaine-trained rats. JF - Psychopharmacology AU - Justinova, Zuzana AU - FerrE, Sergi AU - Barnes, Chanel AU - Wertheim, Carrie E AU - Pappas, Lara A AU - Goldberg, Steven R AU - Le Foll, Bernard AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD, 21224, USA, zjustino@intra.nida.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 355 EP - 367 PB - Springer-Verlag, Heidelberger Platz 3 VL - 203 IS - 2 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Methamphetamine KW - Nicotine KW - Adenosine receptors KW - Food KW - Drug tolerance KW - Caffeine KW - Cocaine KW - Adenosine A2A receptors KW - Drinking water KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20513081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Effects+of+chronic+caffeine+exposure+on+adenosinergic+modulation+of+the+discriminative-stimulus+effects+of+nicotine%2C+methamphetamine%2C+and+cocaine+in+rats&rft.au=Justinova%2C+Zuzana%3BFerrE%2C+Sergi%3BBarnes%2C+Chanel%3BWertheim%2C+Carrie+E%3BPappas%2C+Lara+A%3BGoldberg%2C+Steven+R%3BLe+Foll%2C+Bernard&rft.aulast=Justinova&rft.aufirst=Zuzana&rft.date=2009-04-01&rft.volume=203&rft.issue=2&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-008-1270-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Methamphetamine; Adenosine receptors; Nicotine; Food; Drug tolerance; Caffeine; Drinking water; Adenosine A2A receptors; Cocaine DO - http://dx.doi.org/10.1007/s00213-008-1270-0 ER - TY - JOUR T1 - Human Papillomavirus Genotype Distributions: Implications for Vaccination and Cancer Screening in the United States AN - 20503133; 9195836 AB - Background Limited data are available describing human papillomavirus (HPV) genotype distributions in cervical cancer in the United States. Such studies are needed to predict how HPV vaccination and HPV-based screening will influence cervical cancer prevention.Methods We used the New Mexico Surveillance, Epidemiology, and End Results Registry to ascertain cases of in situ (n = 1213) and invasive (n = 808) cervical cancer diagnosed during 1985-1999 and 1980-1999, respectively, in the state of New Mexico. HPV genotyping was performed using two polymerase chain reaction-based methods on paraffin-embedded tissues from in situ and invasive cancers and on cervical Papanicolaou test specimen from control subjects (ie, women aged 18-40 years attending clinics for routine cervical screening [n = 4007]). Relative risks for cervical cancer were estimated, and factors associated with age at cancer diagnosis and the prevalence of HPV genotypes in cancers were examined.Results The most common HPV genotypes detected in invasive cancers were HPV type 16 (HPV16, 53.2%), HPV18 (13.1%), and HPV45 (6.1%) and those in in situ cancers were HPV16 (56.3%), HPV31 (12.6%), and HPV33 (8.0%). Invasive cancer case subjects who were positive for HPV16 or 18 were diagnosed at younger ages than those who were positive for other carcinogenic HPV genotypes (mean age at diagnosis: 48.1 [95% confidence interval {CI} = 46.6 to 49.6 years], 45.9 [95% CI = 42.9 to 49.0 years], and 52.3 years [95% CI = 50.0 to 54.6 years], respectively). The proportion of HPV16-positive in situ and invasive cancers, but not of HPV18-positive cancers, declined with more recent calendar year of diagnosis, whereas the proportion positive for carcinogenic HPV genotypes other than HPV18 increased.Conclusions HPV16 and 18 caused the majority of invasive cervical cancer in this population sample of US women, but the proportion attributable to HPV16 declined over the last 20 years. The age at diagnosis of HPV16- and HPV18-related cancers was 5 years earlier than that of cancers caused by carcinogenic HPV genotypes other than HPV16 and 18, suggesting that the age at initiation of cervical screening could be delayed in HPV-vaccinated populations. JF - Journal of the National Cancer Institute AU - Wheeler, Cosette M AU - Hunt, William C AU - Joste, Nancy E AU - Key, Charles R AU - Quint, Wim GV AU - Castle, Philip E AD - Affiliations of authors: Department of Molecular Genetics and Microbiology (CMW, WCH), Department of Obstetrics and Gynecology (CMW), Department of Pathology (NEJ, CRK), New Mexico Tumor Registry (CRK), School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM; DDL Diagnostic Laboratory, Voorburg, the Netherlands (WGVQ); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (PEC), cwheeler@salud.unm.edu Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 475 EP - 487 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 101 IS - 7 SN - 0027-8874, 0027-8874 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Risk assessment KW - Cancer vaccines KW - USA, New Mexico KW - Invasiveness KW - Age KW - Data processing KW - Genotyping KW - Cervical cancer KW - Human papillomavirus 18 KW - Genotypes KW - Vaccination KW - Cancer KW - Epidemiology KW - Carcinogenicity KW - Human papillomavirus 16 KW - Cervix KW - Human papillomavirus KW - R2 23060:Medical and environmental health KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20503133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Human+Papillomavirus+Genotype+Distributions%3A+Implications+for+Vaccination+and+Cancer+Screening+in+the+United+States&rft.au=Wheeler%2C+Cosette+M%3BHunt%2C+William+C%3BJoste%2C+Nancy+E%3BKey%2C+Charles+R%3BQuint%2C+Wim+GV%3BCastle%2C+Philip+E&rft.aulast=Wheeler&rft.aufirst=Cosette&rft.date=2009-04-01&rft.volume=101&rft.issue=7&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn510 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Cancer vaccines; Age; Invasiveness; Data processing; Epidemiology; Genotyping; Cervical cancer; Genotypes; Cervix; Vaccination; Carcinogenicity; Cancer; Human papillomavirus 16; Human papillomavirus 18; Human papillomavirus; USA, New Mexico DO - http://dx.doi.org/10.1093/jnci/djn510 ER - TY - JOUR T1 - Multicomponent T2 relaxation analysis in cartilage AN - 20483958; 9180697 AB - MR techniques are sensitive to the early stages of osteoarthritis, characterized by disruption of collagen and loss of proteoglycan (PG), but are of limited specificity. Here, water compartments in normal and trypsin-degraded bovine nasal cartilage were identified using a nonnegative least squares multiexponential analysis of T2 relaxation. Three components were detected: T2,1 = 2.3 ms, T2,2 = 25.2 ms, and T2,3 = 96.3 ms, with fractions w1 = 6.2%, w2 = 14.5%, and w3 = 79.3%, respectively. Trypsinization resulted in increased (P < 0.01) values of T2,2 = 64.2 ms and T2,3 = 149.4 ms, supporting their assignment to water compartments that are bound and loosely associated with PG, respectively. The T2 of the rapidly relaxing component was not altered by digestion, supporting assignment to relatively immobile collagen-bound water. Relaxation data were simulated for a range of TE, number of echoes, and SNR to guide selection of acquisition parameters and assess the accuracy and precision of experimental results. Based on this, the expected experimental accuracy of measured T2s and associated weights was within 2% and 4% respectively, with precision within 1% and 3%. These results demonstrate the potential of multiexponential T2 analysis to increase the specificity of MR characterization of cartilage. Magn Reson Med, 2009. JF - Magnetic Resonance in Medicine AU - Reiter, David A AU - Lin, Ping-Chang AU - Fishbein, Kenneth W AU - Spencer, Richard G AD - Magnetic Resonance Imaging and Spectroscopy Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, spencer@helix.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 803 EP - 809 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 61 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Digestion KW - Proteoglycans KW - Cartilage diseases KW - Data processing KW - Osteoarthritis KW - N.M.R. KW - Collagen KW - W 30910:Imaging KW - T 2030:Cartilage and Cartilage Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20483958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Multicomponent+T2+relaxation+analysis+in+cartilage&rft.au=Reiter%2C+David+A%3BLin%2C+Ping-Chang%3BFishbein%2C+Kenneth+W%3BSpencer%2C+Richard+G&rft.aulast=Reiter&rft.aufirst=David&rft.date=2009-04-01&rft.volume=61&rft.issue=4&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21926 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Proteoglycans; Digestion; Data processing; Cartilage diseases; Osteoarthritis; N.M.R.; Collagen DO - http://dx.doi.org/10.1002/mrm.21926 ER - TY - JOUR T1 - Fast high-resolution T1 mapping using inversion-recovery look-locker echo-planar imaging at steady state: Optimization for accuracy and reliability AN - 20483516; 9180709 AB - A fast T1 measurement sequence using inversion recovery Look-Locker echo-planar imaging at steady state (IR LL-EPI SS) is presented. Delay time for a full magnetization recovery is not required in the sequence, saving acquisition time significantly for high-resolution T1 mapping. Imaging parameters of the IR LL-EPI SS sequence were optimized to minimize the bias from the excitation pulses imperfection and to maximize the accuracy and reliability of T1 measurements, which are critical for its applications. Compared with the conventional inversion recovery Look-Locker echo-planar imaging (IR LL-EPI) sequence, IR LL-EPI SS method preserves similar accuracy and reliability, while saving 20% in acquisition time. Optimized IR LL-EPI SS provided quantitative T1 mapping with 1 X 1 X 4 mm3 resolution and whole-brain coverage (28 slices) in approximately 4 min. Magn Reson Med, 2009. JF - Magnetic Resonance in Medicine AU - Shin, Wanyong AU - Gu, Hong AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA, shinwa@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 899 EP - 906 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 61 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Inversion KW - N.M.R. KW - Mapping KW - imaging KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20483516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Fast+high-resolution+T1+mapping+using+inversion-recovery+look-locker+echo-planar+imaging+at+steady+state%3A+Optimization+for+accuracy+and+reliability&rft.au=Shin%2C+Wanyong%3BGu%2C+Hong%3BYang%2C+Yihong&rft.aulast=Shin&rft.aufirst=Wanyong&rft.date=2009-04-01&rft.volume=61&rft.issue=4&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21836 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inversion; N.M.R.; Mapping; imaging DO - http://dx.doi.org/10.1002/mrm.21836 ER - TY - JOUR T1 - A comprehensive Plasmodium falciparum protein interaction map reveals a distinct architecture of a core interactome AN - 20479770; 9180771 AB - We derive a map of protein interactions in the parasite Plasmodium falciparum from conserved interactions in Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and Escherichia coli and pool them with experimental interaction data. The application of a clique-percolation algorithm allows us to find overlapping clusters, strongly correlated with yeast specific conserved protein complexes. Such clusters contain core activities that govern gene expression, largely dominated by components of protein production and degradation processes as well as RNA metabolism. A critical role of protein hubs in the interactome of P. falciparum is supported by their appearance in multiple clusters and the tendencies of their interactions to reach into many distinct protein clusters. Parasite proteins with a human ortholog tend to appear in single complexes. Annotating each protein with the stage where it is maximally expressed we observe a high level of cluster integrity in the ring stage. While we find no signal in the trophozoite phase, expression patterns are reversed in the schizont phase, implying a preponderance of parasite specific functions in this late, invasive schizont stage. As such, the inference of potential protein interactions and their analysis contributes to our understanding of the parasite, indicating basic pathways and processes as unique targets for therapeutic intervention. JF - Proteomics AU - Wuchty, Stefan AU - Adams, John H AU - Ferdig, Michael T AD - Northwestern Institute of Complexity, Northwestern University, Evanston, IL, USA, wuchtys@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1841 EP - 1849 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 9 IS - 7 SN - 1615-9853, 1615-9853 KW - Microbiology Abstracts B: Bacteriology; Entomology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Parasites KW - Data processing KW - Algorithms KW - Schizonts KW - Therapeutic applications KW - Plasmodium falciparum KW - Saccharomyces cerevisiae KW - Gene expression KW - RNA KW - Caenorhabditis elegans KW - Drosophila melanogaster KW - Escherichia coli KW - Protein turnover KW - proteomics KW - Protein interaction KW - Trophozoites KW - J 02410:Animal Diseases KW - Z 05360:Genetics and Evolution KW - K 03310:Genetics & Taxonomy KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20479770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=A+comprehensive+Plasmodium+falciparum+protein+interaction+map+reveals+a+distinct+architecture+of+a+core+interactome&rft.au=Wuchty%2C+Stefan%3BAdams%2C+John+H%3BFerdig%2C+Michael+T&rft.aulast=Wuchty&rft.aufirst=Stefan&rft.date=2009-04-01&rft.volume=9&rft.issue=7&rft.spage=1841&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159853&rft_id=info:doi/10.1002%2Fpmic.200800383 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Parasites; Data processing; RNA; Algorithms; Therapeutic applications; Protein turnover; Schizonts; proteomics; Protein interaction; Trophozoites; Drosophila melanogaster; Caenorhabditis elegans; Escherichia coli; Plasmodium falciparum; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1002/pmic.200800383 ER - TY - JOUR T1 - Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression AN - 20466823; 9134760 JF - Cancer Causes & Control AU - Figueroa, Jonine D AU - Terry, Mary Beth AU - Gammon, Marilie D AU - Vaughan, Thomas L AU - Risch, Harvey A AU - Zhang, Fang-Fang AU - Kleiner, David E AU - Bennett, William P AU - Howe, Christine L AU - Dubrow, Robert AU - Mayne, Susan T AU - Fraumeni, Joseph F AU - Chow, Wong-Ho AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, figueroaj@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 361 EP - 368 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 20 IS - 3 SN - 0957-5243, 0957-5243 KW - Physical Education Index KW - Smoking KW - Body mass KW - Tobacco KW - Diseases KW - Drugs KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20466823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Cigarette+smoking%2C+body+mass+index%2C+gastro-esophageal+reflux+disease%2C+and+non-steroidal+anti-inflammatory+drug+use+and+risk+of+subtypes+of+esophageal+and+gastric+cancers+by+P53+overexpression&rft.au=Figueroa%2C+Jonine+D%3BTerry%2C+Mary+Beth%3BGammon%2C+Marilie+D%3BVaughan%2C+Thomas+L%3BRisch%2C+Harvey+A%3BZhang%2C+Fang-Fang%3BKleiner%2C+David+E%3BBennett%2C+William+P%3BHowe%2C+Christine+L%3BDubrow%2C+Robert%3BMayne%2C+Susan+T%3BFraumeni%2C+Joseph+F%3BChow%2C+Wong-Ho&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2009-04-01&rft.volume=20&rft.issue=3&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-008-9250-6 LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoking; Body mass; Tobacco; Diseases; Drugs; Cancer DO - http://dx.doi.org/10.1007/s10552-008-9250-6 ER - TY - JOUR T1 - Compliance packaging for over-the-counter drug products AN - 20409436; 9091866 AB - In view of the serious health risks and high costs to the health-care system of misuse and abuse of over-the-counter (OTC) analgesics, this article describes a rationale and prototype for new safety or compliance packaging for OTC drug products that are sold in pill form (e.g., tablets, caplets and gelcaps) inside blister packs. The proposed packaging is not simply promoting the use of blister packs for pills; that utility is already well known. It is an integrated system in which blister packs of pills can, themselves, be packaged, labeled and sold, offering a dose-directed unit-of- use design with enhanced warnings and directions to help prevent consumers from taking more than the instructed dose of pill-form medicines. Method Literature and information searches were conducted in publicly available databases and websites to (1) assess safety problems (serious adverse events and fatalities) associated with OTC analgesics and (2) determine public perceptions and knowledge about their use. Results Each year in the US, there are an estimated 100,000 hospitalizations and 16,500 deaths due to NSAID overdosing, and 26,000 hospitalizations and 1,600 acute liver failure cases due to acetaminophen poisoning. Many adults take more than the recommended dose and in some cases use multiple products containing acetaminophen and ibuprofen. Risk factors, such as alcohol use or pre-existing liver disease, exacerbate problems associated with acetaminophen misuse and abuse. In pediatric cases, dosing errors are often related to confusion over different product formulations, dosing strengths, and the use of inappropriate dosing devices. Consumers are often unaware of the active ingredients in, and correct doses of, drugs they are taking; they underestimate the risks associated with misuse of OTC medicines, and they frequently discard the packaging on which the drug's directions, warnings and dosing instructions are located. Conclusion Optimal compliance packaging should (1) keep the instructions, warnings and dosing directions attached to the blister card of pills at all times, thus avoiding the problem of cartons and package inserts being thrown away once the package is opened; (2) increase the surface area of the packaging, without adding bulk, to provide space for the use of larger font sizes and enhanced directions and warnings that are more conspicuous, explicit and memorable; (3) organize the pills into logical, unit-of-use (per-dose maximum and per-day maximum) sets or rows; (4) limit the number of pills in a unit-of-use package to coincide with the instructed maximum dose and maximum days of use for a specific product. JF - Zeitschrift fuer Gesundheitswissenschaften/Journal of Public Health AU - Weiss, Susanna AD - Division of Clinical Research, Office of Strategic Planning and Assessment, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6700B Rockledge Drive, Rm. 1106, MSC 7609, Bethesda, MD 20892-7609, USA, Weisssu@niaid.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 155 EP - 164 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 17 IS - 2 SN - 0943-1853, 0943-1853 KW - Health & Safety Science Abstracts KW - Dose compliance KW - OTC drugs KW - Packaging KW - Labeling KW - Warnings KW - Directions The term "compliance packaging" is used for this prototype because it is packaging designed to increase consumer compliance and to distinguish it from the more commonly known child-proof safety packaging or tamper-evident packaging. KW - Mortality KW - Alcohol KW - prototypes KW - Compliance KW - Poisoning KW - Public opinion KW - safety engineering KW - Liver KW - Drugs KW - Side effects KW - surface area KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20409436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zeitschrift+fuer+Gesundheitswissenschaften%2FJournal+of+Public+Health&rft.atitle=Compliance+packaging+for+over-the-counter+drug+products&rft.au=Weiss%2C+Susanna&rft.aulast=Weiss&rft.aufirst=Susanna&rft.date=2009-04-01&rft.volume=17&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Zeitschrift+fuer+Gesundheitswissenschaften%2FJournal+of+Public+Health&rft.issn=09431853&rft_id=info:doi/10.1007%2Fs10389-008-0233-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Public opinion; Alcohol; Mortality; safety engineering; prototypes; Compliance; Poisoning; Liver; Drugs; Side effects; surface area; Packaging DO - http://dx.doi.org/10.1007/s10389-008-0233-6 ER - TY - JOUR T1 - Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years AN - 20404838; 9083057 AB - Trivalent chromium (Cr(III)) has been proposed to be an essential element, which may increase sensitivity to insulin and thus participate in carbohydrate and lipid metabolism. Humans ingest Cr(III) both as a natural dietary constituent and in dietary supplements taken for weight loss and antidiabetic effects. Chromium picolinate (CP), a widely used supplement, contains Cr(III) chelated with three molecules of picolinic acid and was formulated in an attempt to improve the absorption of Cr(III). In order to examine the potential for CP to induce chronic toxicity and carcinogenicity, the NTP conducted studies of the monohydrate form (CPM) in groups of 50 male and female F344/N rats and B6C3F1 mice exposed in feed to concentrations of 0, 2000, 10,000 or 50,000ppm for 2 years; exposure concentrations were selected following review of the data from NTP 3-month toxicity studies. Exposure to CPM did not induce biologically significant changes in survival, body weight, feed consumption, or non-neoplastic lesions in rats or mice. In male rats, a statistically significant increase in the incidence of preputial gland adenoma at 10,000ppm was considered an equivocal finding. CPM was not carcinogenic to female rats or to male or female mice. JF - Food and Chemical Toxicology AU - Stout, MD AU - Nyska, A AU - Collins, B J AU - Witt, K L AU - Kissling, GE AU - Malarkey, DE AU - Hooth, MJ AD - National Institute of Environmental Health Sciences, NIEHS, P.O. Box 12233, MD EC-34, Research Triangle Park, NC 27709, USA, stoutm@niehs.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 729 EP - 733 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 47 IS - 4 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Data processing KW - Chromium KW - Statistical analysis KW - Survival KW - Toxicity KW - Insulin KW - Lipid metabolism KW - Body weight loss KW - Preputial gland KW - Diabetes mellitus KW - Body weight KW - Carcinogenicity KW - Reviews KW - Dietary supplements KW - Chronic toxicity KW - picolinic acid KW - Carbohydrates KW - Adenoma KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20404838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Chronic+toxicity+and+carcinogenicity+studies+of+chromium+picolinate+monohydrate+administered+in+feed+to+F344%2FN+rats+and+B6C3F1+mice+for+2+years&rft.au=Stout%2C+MD%3BNyska%2C+A%3BCollins%2C+B+J%3BWitt%2C+K+L%3BKissling%2C+GE%3BMalarkey%2C+DE%3BHooth%2C+MJ&rft.aulast=Stout&rft.aufirst=MD&rft.date=2009-04-01&rft.volume=47&rft.issue=4&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2009.01.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Chromium; Statistical analysis; Survival; Toxicity; Insulin; Lipid metabolism; Diabetes mellitus; Preputial gland; Body weight loss; Body weight; Carcinogenicity; Chronic toxicity; Dietary supplements; Reviews; picolinic acid; Carbohydrates; Adenoma DO - http://dx.doi.org/10.1016/j.fct.2009.01.006 ER - TY - JOUR T1 - Methamphetamine Preconditioning: Differential Protective Effects on Monoaminergic Systems in the Rat Brain AN - 20143635; 10263415 AB - Pretreatment with methamphetamine (METH) can attenuate toxicity due to acute METH challenges. The majority of previous reports have focused mainly on the effects of the drug on the striatal dopaminergic system. In the present study, we used a regimen that involves gradual increases in METH administration to rats in order to mimic progressively larger doses of the drug used by some human METH addicts. We found that this METH preconditioning was associated with complete protection against dopamine depletion caused by a METH challenge (5 mg/kg X 6 injections given 1 h apart) in the striatum and cortex. In contrast, there was no preconditioning-mediated protection against METH-induced serotonin depletion in the striatum and hippocampus, with some protection being observed in the cortex. There was also no protection against METH-induced norepinephrine (NE) depletion in the hippocampus. These results indicate that, in contrast to the present dogmas, there might be differences in the mechanisms involved in METH toxicity on monoaminergic systems in the rodent brain. Thus, chronic injections of METH might activate programs that protect against dopamine toxicity without influencing drug-induced pathological changes in serotoninergic systems. Further studies will need to evaluate the cellular and molecular bases for these differential responses. JF - Neurotoxicity Research AU - Cadet, Jean Lud AU - Krasnova, Irina N AU - Ladenheim, Bruce AU - Cai, Ning-Sheng AU - McCoy, Michael T AU - Atianjoh, Fidelis E AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse/NIH/DHHS, 251 Bayview Boulevard, Baltimore, MD 21224, USA, jcadet@intra.nida.nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 252 EP - 259 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 15 IS - 3 SN - 1029-8428, 1029-8428 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Methamphetamine KW - Dopamine KW - Cortex KW - Addicts KW - Hippocampus KW - Neurotoxicity KW - Neostriatum KW - Norepinephrine KW - Brain KW - Drug abuse KW - Serotonin KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20143635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+Research&rft.atitle=Methamphetamine+Preconditioning%3A+Differential+Protective+Effects+on+Monoaminergic+Systems+in+the+Rat+Brain&rft.au=Cadet%2C+Jean+Lud%3BKrasnova%2C+Irina+N%3BLadenheim%2C+Bruce%3BCai%2C+Ning-Sheng%3BMcCoy%2C+Michael+T%3BAtianjoh%2C+Fidelis+E&rft.aulast=Cadet&rft.aufirst=Jean&rft.date=2009-04-01&rft.volume=15&rft.issue=3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+Research&rft.issn=10298428&rft_id=info:doi/10.1007%2Fs12640-009-9026-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Methamphetamine; Cortex; Dopamine; Addicts; Hippocampus; Norepinephrine; Neostriatum; Neurotoxicity; Brain; Drug abuse; Serotonin DO - http://dx.doi.org/10.1007/s12640-009-9026-0 ER - TY - JOUR T1 - Determination of free and protein-bound glutathione in HepG2 cells using capillary electrophoresis with laser-induced fluorescence detection AN - 20074832; 10133749 AB - A rapid method using capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) was developed to determine free and protein-bound glutathione (GSH) in human HepG2 hepatocarcinoma cells. The samples were derivatized with 5-iodoacetamidofluorescein (5-IAF), and analyzed at 22 kV using sodium phosphate buffer (10 mM, pH 11.4) and an uncoated 58 cm x 75 km I.D. fused silica capillary. The analysis time was less than 10 min and N-acetylcysteine was used as internal standard. The derivatization conditions, such as reaction time, 5-IAF concentration, running buffer and cartridge temperature were optimized. Argon gas was used in the study to prevent the oxidization of GSH during sample preparation. The optimized method required only 30-40 nl sample per analysis and was fast and sensitive. The method was applied to the analyses of HepG2 cells treated with the small metal chelating agent, pyrrolidine dithiocarbamate (PDTC). The results demonstrate that the amount of protein-bound GSH, which reflects the amount of protein S-glutathionylation, increased in a time-dependent manner upon cell treatment with PDTC, reaching a maximum of over 50% increase 2 h post-PDTC. JF - Journal of Chromatography A AU - Wang, Yan AU - Xie, Yi AU - Bernier, Michel AU - Wainer, Irving W AD - Laboratory of Clinical Investigation, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA, wangy5@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 3533 EP - 3537 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 1216 IS - 16 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts; Toxicology Abstracts KW - Glutathione KW - Pyrrolidine dithiocarbamate KW - 5-Iodoacetamidofluorescein KW - HepG2 cell KW - Capillary electrophoresis KW - Laser-induced fluorescence KW - Chromatographic techniques KW - Chelating agents KW - Sample Preparation KW - sodium phosphate KW - Argon KW - pyrrolidine dithiocarbamate KW - Pyrrolidine KW - capillary electrophoresis KW - Acetylcysteine KW - Coenzymes KW - Chelates KW - pH effects KW - Temperature effects KW - Metals KW - Electrophoresis KW - Fluorescence KW - Sodium KW - Phosphates KW - Silica KW - Analytical techniques KW - Standards KW - Chelating Agents KW - X 24390:Radioactive Materials KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20074832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Determination+of+free+and+protein-bound+glutathione+in+HepG2+cells+using+capillary+electrophoresis+with+laser-induced+fluorescence+detection&rft.au=Wang%2C+Yan%3BXie%2C+Yi%3BBernier%2C+Michel%3BWainer%2C+Irving+W&rft.aulast=Wang&rft.aufirst=Yan&rft.date=2009-04-01&rft.volume=1216&rft.issue=16&rft.spage=3533&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2008.06.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Fluorescence; Chromatographic techniques; Analytical techniques; Pyrrolidine; Coenzymes; Chelates; Temperature effects; Metals; Argon; Silica; sodium phosphate; pyrrolidine dithiocarbamate; Glutathione; capillary electrophoresis; Acetylcysteine; Chelating agents; pH effects; Sodium; Sample Preparation; Phosphates; Electrophoresis; Standards; Chelating Agents DO - http://dx.doi.org/10.1016/j.chroma.2008.06.027 ER - TY - JOUR T1 - Nanomedicine for the management of lung and blood diseases AN - 1464513489; 18788004 AB - Nanotechnology provides a broad range of opportunities to develop new solutions for clinical problems. For the pulmonary field, nanotechnology promises better delivery of drugs and nucleic acid-based therapeutics to disease sites. Administration of therapeutics via inhalation provides the opportunity for direct delivery to the lung epithelium, the lining of the respiratory tract. By appropriate selection of particle size, deep lung delivery can be obtained with control of phagocytic uptake, the removal of particles by resident macrophages. Nanotechnology can also help in pulmonary therapies administered by intravenous and oral routes through targeting specific cell types and controlling bioavailability and release kinetics. In the hematology field, nanotechnology can counter multiple drug resistance in leukemia by blocking drug efflux from cancer cells, and provide effective delivery of siRNA into lymphocytes to block apoptosis in sepsis. Controlling the surface properties of materials on devices such as valves and stents promises improved biocompatibility by inhibition of thrombosis, the formation of blood clots, and regulating cell adhesion and activation. Nanoparticle-based thrombolytic agents have the potential to improve the effectiveness of clot removal. Treatment of both lung and blood diseases is also likely to benefit from nano-scaffold-based methods for controlling the differentiation and proliferation of stem and progenitor cells. JF - Nanomedicine AU - Buxton, Denis B AD - Advanced Technologies & Surgery Branch, Division of Cardiovascular Diseases, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Suite 8216, Bethesda, MD 20892, USA., db225a@nih.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 331 EP - 339 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 4 IS - 3 SN - 1743-5889, 1743-5889 KW - Biotechnology and Bioengineering Abstracts KW - Macrophages KW - Biocompatibility KW - thrombolysis KW - Intravenous administration KW - Apoptosis KW - Drug resistance KW - Lung diseases KW - Cancer KW - Cell adhesion KW - Cell activation KW - Blood KW - Differentiation KW - Surface properties KW - Blood coagulation KW - siRNA KW - Lung KW - Cell proliferation KW - Respiratory tract KW - nanotechnology KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1464513489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine&rft.atitle=Nanomedicine+for+the+management+of+lung+and+blood+diseases&rft.au=Buxton%2C+Denis+B&rft.aulast=Buxton&rft.aufirst=Denis&rft.date=2009-04-01&rft.volume=4&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Nanomedicine&rft.issn=17435889&rft_id=info:doi/10.2217%2Fnnm.09.8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-11-01 N1 - Number of references - 53 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Macrophages; Intravenous administration; thrombolysis; Biocompatibility; Apoptosis; Drug resistance; Lung diseases; Cancer; Cell activation; Cell adhesion; Differentiation; Blood; Blood coagulation; Surface properties; siRNA; Lung; Cell proliferation; nanotechnology; Respiratory tract DO - http://dx.doi.org/10.2217/nnm.09.8 ER - TY - JOUR T1 - Environmental toxicity, oxidative stress and apoptosis: Menage a Trois AN - 20415307; 9091100 AB - Apoptosis is an evolutionary conserved homeostatic process involved in distinct physiological processes including organ and tissue morphogenesis, development and senescence. Its deregulation is also known to participate in the etiology of several human diseases including cancer, neurodegenerative and autoimmune disorders. Environmental stressors (cytotoxic agents, pollutants or toxicants) are well known to induce apoptotic cell death and to contribute to a variety of pathological conditions. Oxidative stress seems to be the central element in the regulation of the apoptotic pathways triggered by environmental stressors. In this work, we review the established mechanisms by which oxidative stress and environmental stressors regulate the apoptotic machinery with the aim to underscore the relevance of apoptosis as a component in environmental toxicity and human disease progression. cells JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis AU - Franco, R AU - Sanchez-Olea, R AU - Reyes-Reyes, E M AU - Panayiotidis, MI AD - National Institute of Environmental Health Sciences, P. O. Box 12233, 111. T.W. Alexander Drive, Research Triangle Park, NC 27709, United States, franco2@mail.nih.gov Y1 - 2009/03/31/ PY - 2009 DA - 2009 Mar 31 SP - 3 EP - 22 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 674 IS - 1-2 SN - 1383-5718, 1383-5718 KW - Genetics Abstracts; Toxicology Abstracts KW - Evolutionary conservation KW - Etiology KW - Apoptosis KW - Toxicants KW - Autoimmune diseases KW - Morphogenesis KW - Cytotoxic agents KW - Development KW - Toxicity KW - Cancer KW - Mutagenesis KW - Pollutants KW - Oxidative stress KW - Reviews KW - Senescence KW - X 24310:Pharmaceuticals KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20415307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Environmental+toxicity%2C+oxidative+stress+and+apoptosis%3A+Menage+a+Trois&rft.au=Franco%2C+R%3BSanchez-Olea%2C+R%3BReyes-Reyes%2C+E+M%3BPanayiotidis%2C+MI&rft.aulast=Franco&rft.aufirst=R&rft.date=2009-03-31&rft.volume=674&rft.issue=1-2&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2008.11.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Evolutionary conservation; Etiology; Apoptosis; Toxicants; Morphogenesis; Autoimmune diseases; Cytotoxic agents; Toxicity; Development; Cancer; Mutagenesis; Pollutants; Oxidative stress; Reviews; Senescence DO - http://dx.doi.org/10.1016/j.mrgentox.2008.11.012 ER - TY - JOUR T1 - Sympathetic nervous system control of anti-influenza CD8 super(+) T cell responses AN - 20207283; 10313969 AB - Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remain enigmatic. Here, we show that 6-hydroxydopamine-mediated ablation of the mouse peripheral sympathetic nervous system increases primary CD8 super(+) T cell responses to viral and cellular antigens presented by direct priming or cross-priming. The sympathetic nervous system also suppresses antiviral CD4 super(+) T cell responses, but this is not required for suppressing CD8 super(+) T cell responses. Adoptive transfer experiments indicate that enhanced CD8 super(+) responses do not result from permanent alterations in CD8 super(+) T cell function in sympathectomized mice. Rather, additional findings suggest that the sympathetic nervous system tempers the capacity of antigen-presenting cells to activate na¯ve CD8 super(+) T cells. We also show that antiviral CD8 super(+) T cell responses are enhanced by administration of a b sub(2) (but not b sub(1) or a) adrenergic antagonist. These findings demonstrate a critical role for the sympathetic nervous system in limiting CD8 super(+) T cell responses and indicate that CD8 super(+) T cell responses may be altered in patients using b- blockers, one of the most widely prescribed classes of drugs. JF - Proceedings of the National Academy of Sciences, USA AU - Grebe, Kristie M AU - Hickman, Heather D AU - Irvine, Kari R AU - Takeda, Kazuyo AU - Bennink, Jack R AU - Yewdell, Jonathan W AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, jyewdell@nih.gov Y1 - 2009/03/31/ PY - 2009 DA - 2009 Mar 31 SP - 5300 EP - 5305 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 13 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; CSA Neurosciences Abstracts; Virology & AIDS Abstracts KW - antigen presentation KW - vaccine KW - cross-priming KW - direct-priming KW - dendritic cell KW - CD4 antigen KW - Antiviral agents KW - Immune system KW - Lymphocytes T KW - Adoptive transfer KW - Communication KW - Sympathetic nervous system KW - CD8 antigen KW - Antigen-presenting cells KW - Antigen presentation KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites KW - V 22400:Human Diseases KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20207283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Sympathetic+nervous+system+control+of+anti-influenza+CD8+super%28%2B%29+T+cell+responses&rft.au=Grebe%2C+Kristie+M%3BHickman%2C+Heather+D%3BIrvine%2C+Kari+R%3BTakeda%2C+Kazuyo%3BBennink%2C+Jack+R%3BYewdell%2C+Jonathan+W&rft.aulast=Grebe&rft.aufirst=Kristie&rft.date=2009-03-31&rft.volume=106&rft.issue=13&rft.spage=5300&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0808851106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - CD4 antigen; Antiviral agents; Immune system; Communication; Adoptive transfer; Lymphocytes T; Sympathetic nervous system; Antigen-presenting cells; CD8 antigen; Antigen presentation DO - http://dx.doi.org/10.1073/pnas.0808851106 ER - TY - JOUR T1 - Biometric identification using knee X-rays AN - 21004254; 9295907 AB - Identification of people often makes use of unique features of the face, fingerprints and retina. Beyond this, a similar identifying process can be applied to internal parts of the body that are not visible to the unaided eye. Here we show that knee X-rays can be used for the identification of individual persons. The image analysis method is based on the wnd-charm algorithm, which has been found effective for the diagnosis of clinical conditions of knee joints. Experimental results show that the rank-10 identification accuracy using a dataset of 425 individuals is ∼ 56% , and the rank-1 accuracy is ∼ 34% . The dataset contained knee X-rays taken several years apart from each other, showing that the identifiable features correspond to specific persons, rather than the present clinical condition of the joint. JF - International Journal of Biometrics AU - Shamir, Lior AU - Ling, Shari AU - Rahimi, Salim AU - Ferrucci, Luigi AU - Goldberg, Ilya G AD - Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 251 Bayview boulevard, Baltimore, MD 21224, USA. Y1 - 2009/03/30/ PY - 2009 DA - 2009 Mar 30 SP - 365 EP - 370 PB - Inderscience Publishers Ltd., PO Box 735 VL - 1 IS - 3 SN - 1755-8301, 1755-8301 KW - Biotechnology and Bioengineering Abstracts KW - TECHNICAL JOURNALS KW - COMPUTING AND MATHEMATICS JOURNALS KW - RISK, SAFETY AND EMERGENCY JOURNALS KW - Biosciences and Bioinformatics KW - Computing Science, Applications and Software KW - Electronic Systems, Control and Artificial Intelligence KW - Security and Emergency Management KW - Retina KW - Eye KW - Ionizing radiation KW - Algorithms KW - Image processing KW - Biometrics KW - Knee KW - Joints KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21004254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Biometrics&rft.atitle=Biometric+identification+using+knee+X-rays&rft.au=Shamir%2C+Lior%3BLing%2C+Shari%3BRahimi%2C+Salim%3BFerrucci%2C+Luigi%3BGoldberg%2C+Ilya+G&rft.aulast=Shamir&rft.aufirst=Lior&rft.date=2009-03-30&rft.volume=1&rft.issue=3&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Biometrics&rft.issn=17558301&rft_id=info:doi/10.1504%2FIJBM.2009.024279 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Eye; Retina; Ionizing radiation; Algorithms; Image processing; Biometrics; Knee; Joints DO - http://dx.doi.org/10.1504/IJBM.2009.024279 ER - TY - JOUR T1 - Human papillomavirus type 16 E2 and E6 are RNA-binding proteins and inhibit in vitro splicing of pre-mRNAs with suboptimal splice sites AN - 20414893; 9090525 AB - Human papillomavirus type 16 (HPV16) genome expresses six regulatory proteins (E1, E2, E4, E5, E6, and E7) which regulate viral DNA replication, gene expression, and cell function. We expressed HPV16 E2, E4, E6, and E7 from bacteria as GST fusion proteins and examined their possible functions in RNA splicing. Both HPV16 E2, a viral transactivator protein, and E6, a viral oncoprotein, inhibited splicing of pre-mRNAs containing an intron with suboptimal splice sites, whereas HPV5 E2 did not. The N-terminal half and the hinge region of HPV16 E2 as well as the N-terminal and central portions of HPV16 E6 are responsible for the suppression. HPV16 E2 interacts with pre-mRNAs through its C-terminal DNA-binding domain. HPV16 E6 binds pre-mRNAs via nuclear localization signal (NLS3) in its C-terminal half. Low-risk HPV6 E6, a cytoplasmic protein, does not bind RNA. Notably, both HPV16 E2 and E6 selectively bind to the intron region of pre-mRNAs and interact with a subset of cellular SR proteins. Together, these findings suggest that HPV16 E2 and E6 are RNA binding proteins and might play roles in posttranscriptional regulation during virus infection. JF - Virology AU - Bodaghi, S AU - Jia, R AU - Zheng, Z M AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, zhengt@exchange.nih.gov Y1 - 2009/03/30/ PY - 2009 DA - 2009 Mar 30 SP - 32 EP - 43 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 386 IS - 1 SN - 0042-6822, 0042-6822 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Genomes KW - DNA biosynthesis KW - RNA-binding protein KW - Replication KW - Infection KW - SR protein KW - Gene expression KW - Splicing KW - RNA KW - regulatory proteins KW - Human papillomavirus 16 KW - Introns KW - Risk groups KW - Fusion protein KW - Post-transcription KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure KW - V 22320:Replication KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20414893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Human+papillomavirus+type+16+E2+and+E6+are+RNA-binding+proteins+and+inhibit+in+vitro+splicing+of+pre-mRNAs+with+suboptimal+splice+sites&rft.au=Bodaghi%2C+S%3BJia%2C+R%3BZheng%2C+Z+M&rft.aulast=Bodaghi&rft.aufirst=S&rft.date=2009-03-30&rft.volume=386&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2008.12.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; DNA biosynthesis; RNA-binding protein; Replication; Infection; SR protein; Gene expression; Splicing; regulatory proteins; RNA; Introns; Risk groups; Fusion protein; Post-transcription; Human papillomavirus 16 DO - http://dx.doi.org/10.1016/j.virol.2008.12.037 ER - TY - JOUR T1 - Cell type specific accumulation of the major latency-associated transcript (LAT) of herpes simplex virus type 2 in LAT transgenic mice AN - 20413160; 9090518 AB - We performed in situ hybridization to determine the cell type specific accumulation of the intron of the latency-associated transcript (LAT) in tissues in HSV-2 LAT transgenic mice in which LAT expression is driven by its native promoter. We identified LAT in multiple cell types in most tissues analyzed from HSV-2 LAT transgenic mice. While weak to moderate signals were seen in brain and spinal cord neurons, epithelial cells, and muscle cells, the strongest signals were detected in neurons from dorsal root and trigeminal ganglia. About 70-86% of neurons in these ganglia were LAT-positive with varying signal intensities, while cells surrounding the neurons were LAT-negative. The frequency of A5 or KH10-positive neurons was similar in LAT-positive and total neurons. These data indicate that HSV-2 LAT promoter activity is not restricted to neurons and that LAT accumulation in ganglionic neurons is likely regulated by cell-specific factors. JF - Virology AU - Wang, K AU - Mahalingam, G AU - Imai, Y AU - Pesnicak, L AU - Margolis, T T AU - Straus, SE AU - Cohen, JI AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, 10 Center Drive, Room 11N234 Bethesda, MD 20892, USA, kwang@niaid.nih.gov Y1 - 2009/03/30/ PY - 2009 DA - 2009 Mar 30 SP - 79 EP - 87 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 386 IS - 1 SN - 0042-6822, 0042-6822 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Virology & AIDS Abstracts KW - Epithelial cells KW - Data processing KW - Spinal cord KW - Dorsal roots KW - Brain KW - Muscles KW - Transcription KW - Trigeminal ganglion KW - Herpes simplex virus 2 KW - Transgenic mice KW - Promoters KW - Neurons KW - Introns KW - Ganglia KW - W 30925:Genetic Engineering KW - V 22410:Animal Diseases KW - G 07730:Development & Cell Cycle KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20413160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Cell+type+specific+accumulation+of+the+major+latency-associated+transcript+%28LAT%29+of+herpes+simplex+virus+type+2+in+LAT+transgenic+mice&rft.au=Wang%2C+K%3BMahalingam%2C+G%3BImai%2C+Y%3BPesnicak%2C+L%3BMargolis%2C+T+T%3BStraus%2C+SE%3BCohen%2C+JI&rft.aulast=Wang&rft.aufirst=K&rft.date=2009-03-30&rft.volume=386&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2008.12.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Data processing; Spinal cord; Muscles; Brain; Dorsal roots; Transcription; Trigeminal ganglion; Transgenic mice; Promoters; Neurons; Introns; Ganglia; Herpes simplex virus 2 DO - http://dx.doi.org/10.1016/j.virol.2008.12.035 ER - TY - CPAPER T1 - Myeloid Differentiation Primary Response Protein 88 Couples Reverse Cholesterol Transport to Inflammation T2 - 2009 Keystone Symposia on Dendritic Cells (Z2) AN - 41952358; 5114079 JF - 2009 Keystone Symposia on Dendritic Cells (Z2) AU - Smoak, Kathleen Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - Cholesterol KW - Differentiation KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41952358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.atitle=Myeloid+Differentiation+Primary+Response+Protein+88+Couples+Reverse+Cholesterol+Transport+to+Inflammation&rft.au=Smoak%2C+Kathleen&rft.aulast=Smoak&rft.aufirst=Kathleen&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Host ER-Parasitophorous Vacuole Interaction Provides a Route of Entry for Antigen Cross-Presentation in Toxoplasma Infected Dendritic Cells T2 - 2009 Keystone Symposia on Dendritic Cells (Z2) AN - 41927267; 5113974 JF - 2009 Keystone Symposia on Dendritic Cells (Z2) AU - Goldszmid, Romina Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - Vacuoles KW - Dendritic cells KW - Antigen presentation KW - Antigens KW - Toxoplasma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41927267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.atitle=Host+ER-Parasitophorous+Vacuole+Interaction+Provides+a+Route+of+Entry+for+Antigen+Cross-Presentation+in+Toxoplasma+Infected+Dendritic+Cells&rft.au=Goldszmid%2C+Romina&rft.aulast=Goldszmid&rft.aufirst=Romina&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemotaxis Signaling in Dictyostelium and Neutrophils T2 - 2009 Gordon Research Conference on Gradient Sensing and Directed Cell Migration AN - 41911980; 5115749 JF - 2009 Gordon Research Conference on Gradient Sensing and Directed Cell Migration AU - Parent, Carole Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - Signal transduction KW - Leukocytes (neutrophilic) KW - Chemotaxis KW - Dictyostelium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41911980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Gradient+Sensing+and+Directed+Cell+Migration&rft.atitle=Chemotaxis+Signaling+in+Dictyostelium+and+Neutrophils&rft.au=Parent%2C+Carole&rft.aulast=Parent&rft.aufirst=Carole&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Gradient+Sensing+and+Directed+Cell+Migration&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=gradient LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TLR Signaling in DC: Lessons from Fibroblasts T2 - 2009 Keystone Symposia on Dendritic Cells (Z2) AN - 41904032; 5114028 JF - 2009 Keystone Symposia on Dendritic Cells (Z2) AU - Trinchieri, Giorgio Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - Fibroblasts KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41904032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.atitle=TLR+Signaling+in+DC%3A+Lessons+from+Fibroblasts&rft.au=Trinchieri%2C+Giorgio&rft.aulast=Trinchieri&rft.aufirst=Giorgio&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Dendritic Cell Function by Progesterone T2 - 2009 Keystone Symposia on Pattern Recognition Molecules and Immune Sensors of Pathogens (Z1) AN - 41903251; 5114212 JF - 2009 Keystone Symposia on Pattern Recognition Molecules and Immune Sensors of Pathogens (Z1) AU - Butts, Cherie Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - Progesterone KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41903251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Pattern+Recognition+Molecules+and+Immune+Sensors+of+Pathogens+%28Z1%29&rft.atitle=Regulation+of+Dendritic+Cell+Function+by+Progesterone&rft.au=Butts%2C+Cherie&rft.aulast=Butts&rft.aufirst=Cherie&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Pattern+Recognition+Molecules+and+Immune+Sensors+of+Pathogens+%28Z1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ribosomal Protein S3: A Novel Non-Rel Subunit of NF-kappaB Confers Regulatory Specificity T2 - 2009 Keystone Symposia on Pattern Recognition Molecules and Immune Sensors of Pathogens (Z1) AN - 41903084; 5114169 JF - 2009 Keystone Symposia on Pattern Recognition Molecules and Immune Sensors of Pathogens (Z1) AU - Wan, Fengyi Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - Ribosomal protein S3 KW - NF-B protein KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41903084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Pattern+Recognition+Molecules+and+Immune+Sensors+of+Pathogens+%28Z1%29&rft.atitle=Ribosomal+Protein+S3%3A+A+Novel+Non-Rel+Subunit+of+NF-kappaB+Confers+Regulatory+Specificity&rft.au=Wan%2C+Fengyi&rft.aulast=Wan&rft.aufirst=Fengyi&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Pattern+Recognition+Molecules+and+Immune+Sensors+of+Pathogens+%28Z1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Th1/Th2 Polarizing Functions of Dendritic Cells in the Immune Response to Parasites T2 - 2009 Keystone Symposia on Dendritic Cells (Z2) AN - 41902084; 5114065 JF - 2009 Keystone Symposia on Dendritic Cells (Z2) AU - Sher, Alan Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - Parasites KW - Immune response KW - Lymphocytes T KW - Helper cells KW - Dendritic cells KW - Immunity KW - Defense mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.atitle=Th1%2FTh2+Polarizing+Functions+of+Dendritic+Cells+in+the+Immune+Response+to+Parasites&rft.au=Sher%2C+Alan&rft.aulast=Sher&rft.aufirst=Alan&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TLR Signaling in DC: Lessons from Fibroblasts T2 - 2009 Keystone Symposia on Pattern Recognition Molecules and Immune Sensors of Pathogens (Z1) AN - 41901660; 5114160 JF - 2009 Keystone Symposia on Pattern Recognition Molecules and Immune Sensors of Pathogens (Z1) AU - Trinchieri, Giorgio Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - Fibroblasts KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41901660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Pattern+Recognition+Molecules+and+Immune+Sensors+of+Pathogens+%28Z1%29&rft.atitle=TLR+Signaling+in+DC%3A+Lessons+from+Fibroblasts&rft.au=Trinchieri%2C+Giorgio&rft.aulast=Trinchieri&rft.aufirst=Giorgio&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Pattern+Recognition+Molecules+and+Immune+Sensors+of+Pathogens+%28Z1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Structure of NALP1/NLRP1 Leucine-rich Repeats Illustrates a Potential Ligand-binding Site T2 - 2009 Keystone Symposia on Dendritic Cells (Z2) AN - 41900113; 5114016 JF - 2009 Keystone Symposia on Dendritic Cells (Z2) AU - Xiao, Tsan Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41900113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.atitle=The+Structure+of+NALP1%2FNLRP1+Leucine-rich+Repeats+Illustrates+a+Potential+Ligand-binding+Site&rft.au=Xiao%2C+Tsan&rft.aulast=Xiao&rft.aufirst=Tsan&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease T2 - 2009 Keystone Symposia on Dendritic Cells (Z2) AN - 41896782; 5114090 JF - 2009 Keystone Symposia on Dendritic Cells (Z2) AU - Kastner, Daniel Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41896782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.atitle=Horror+Autoinflammaticus%3A+The+Molecular+Pathophysiology+of+Autoinflammatory+Disease&rft.au=Kastner%2C+Daniel&rft.aulast=Kastner&rft.aufirst=Daniel&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monocytes are Precursors of F4/80highCD11cint Macrophage-Like Cells and CD11chighF4/80int Dendritic Cells in the Mouse Colon T2 - 2009 Keystone Symposia on Dendritic Cells (Z2) AN - 41896697; 5114069 JF - 2009 Keystone Symposia on Dendritic Cells (Z2) AU - Rivollier, Aymeric Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - Colon KW - Dendritic cells KW - Monocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41896697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.atitle=Monocytes+are+Precursors+of+F4%2F80highCD11cint+Macrophage-Like+Cells+and+CD11chighF4%2F80int+Dendritic+Cells+in+the+Mouse+Colon&rft.au=Rivollier%2C+Aymeric&rft.aulast=Rivollier&rft.aufirst=Aymeric&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Mechanism of Type I Interferon Transcription in Dendritic Cells T2 - 2009 Keystone Symposia on Dendritic Cells (Z2) AN - 41896661; 5114055 JF - 2009 Keystone Symposia on Dendritic Cells (Z2) AU - Ozato, Keiko Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 KW - Interferon KW - Dendritic cells KW - Transcription KW - Molecular modelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41896661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.atitle=Molecular+Mechanism+of+Type+I+Interferon+Transcription+in+Dendritic+Cells&rft.au=Ozato%2C+Keiko&rft.aulast=Ozato&rft.aufirst=Keiko&rft.date=2009-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Dendritic+Cells+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases AN - 20446998; 9132923 AB - Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, accelerating and boosting antigen-specific immune responses. CpG motifs promote the induction of Th1 and pro-inflammatory cytokines and support the maturation/activation of professional antigen presenting cells (particularly plasmacytoid dendritic cells). These effects are optimized by maintaining close physical contact between the CpG ODN and the immunogen. Co-administering CpG ODN with a variety of vaccines has improved the resultant humoral and/or cellular immune responses, culminating in enhanced protective immunity in rodent and primate challenge models. Ongoing clinical studies indicate that CpG ODN are safe and well-tolerated when administered as adjuvants to humans, and that they can support increased vaccine-specific immune responses. JF - Advanced Drug Delivery Reviews AU - Klinman, Dennis M AU - Klaschik, Sven AU - Sato, Takashi AU - Tross, Debbie AD - Laboratory of Experimental Immunology, National Cancer Institute at Frederick, Frederick, MD 21702, United States, klinmand@mail.nih.gov Y1 - 2009/03/28/ PY - 2009 DA - 2009 Mar 28 SP - 248 EP - 255 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 61 IS - 3 SN - 0169-409X, 0169-409X KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - CpG KW - Adjuvant KW - Vaccine KW - Immunogenicity KW - Antibody KW - IFNg KW - Protection KW - Drug delivery KW - Helper cells KW - Animal models KW - Adjuvants KW - CpG islands KW - Primates KW - Oligonucleotides KW - Cell activation KW - Inflammation KW - Dendritic cells KW - Infectious diseases KW - Lymphocytes T KW - Cytokines KW - Antigen-presenting cells KW - Vaccines KW - Immune response KW - N 14840:Antisense, Nucleotide Analogs KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20446998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=CpG+oligonucleotides+as+adjuvants+for+vaccines+targeting+infectious+diseases&rft.au=Klinman%2C+Dennis+M%3BKlaschik%2C+Sven%3BSato%2C+Takashi%3BTross%2C+Debbie&rft.aulast=Klinman&rft.aufirst=Dennis&rft.date=2009-03-28&rft.volume=61&rft.issue=3&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2008.12.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Drug delivery; Helper cells; Animal models; CpG islands; Adjuvants; Oligonucleotides; Inflammation; Cell activation; Dendritic cells; Infectious diseases; Lymphocytes T; Cytokines; Immune response; Vaccines; Antigen-presenting cells; Primates DO - http://dx.doi.org/10.1016/j.addr.2008.12.012 ER - TY - CPAPER T1 - NCI Chemical Biology Consortium (CBC) T2 - 2009 Keystone Symposia on Targeted Cancer Therapies (X8) AN - 41935985; 5113232 JF - 2009 Keystone Symposia on Targeted Cancer Therapies (X8) AU - Forry-Schaudies, Suzanne Y1 - 2009/03/27/ PY - 2009 DA - 2009 Mar 27 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41935985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Targeted+Cancer+Therapies+%28X8%29&rft.atitle=NCI+Chemical+Biology+Consortium+%28CBC%29&rft.au=Forry-Schaudies%2C+Suzanne&rft.aulast=Forry-Schaudies&rft.aufirst=Suzanne&rft.date=2009-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Targeted+Cancer+Therapies+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=96 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A multi-valent vaccinia virus-based tuberculosis vaccine molecularly adjuvanted with interleukin-15 induces robust immune responses in mice AN - 746228683; 12976938 AB - Tuberculosis caused by Mycobacterium tuberculosis is responsible for nearly two million deaths every year globally. A single licensed vaccine derived from Mycobacterium bovis, bacille Calmette-Guerin (BCG) administered perinatally as a prophylactic vaccine has been in use for over 80 years and confers substantial protection against childhood tuberculous meningitis and miliary tuberculosis. However, the BCG vaccine is virtually ineffective against the adult pulmonary form of tuberculosis that is pivotal in the transmission of tuberculosis that has infected almost 33% of the global population. Thus, an effective vaccine to both prevent tuberculosis and reduce its transmission is urgently needed. We have generated a multi-valent, vectored vaccine candidate utilizing the modified virus Ankara (MVA) strain of vaccinia virus to tandemly express five antigens, ESAT6, Ag85A, Ag85B, HSP65 and Mtb39A of M. tuberculosis that have been reported to be protective individually in certain animal models together with an immunostimulatory cytokine interleukin-15 (MVA/IL-15/5Mtb). Although, immunological correlates of protection against tuberculosis in humans remain to be established, we demonstrate that our vaccine induced comparable CD4 super(+) T cell and greater CD8 super(+) T cell and antibody responses against M. tuberculosis in vaccinated mice in a direct comparison with the BCG vaccine and conferred protection against an aerogenic challenge of M. tuberculosis, thus warranting its further preclinical development. JF - Vaccine AU - Perera, Pin-Yu AU - Derrick, Steven C AU - Kolibab, Kristopher AU - Momoi, Fumiki AU - Yamamoto, Masafumi AU - Morris, Sheldon L AU - Waldmann, Thomas A AU - Perera, Liyanage P AD - Veterans Affairs Medical Center, Washington, DC 20422, USA, pereral@mail.nih.gov Y1 - 2009/03/26/ PY - 2009 DA - 2009 Mar 26 SP - 2121 EP - 2127 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 27 IS - 15 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Animal models KW - Tuberculosis KW - Mycobacterium bovis KW - V 22350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746228683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=A+multi-valent+vaccinia+virus-based+tuberculosis+vaccine+molecularly+adjuvanted+with+interleukin-15+induces+robust+immune+responses+in+mice&rft.au=Perera%2C+Pin-Yu%3BDerrick%2C+Steven+C%3BKolibab%2C+Kristopher%3BMomoi%2C+Fumiki%3BYamamoto%2C+Masafumi%3BMorris%2C+Sheldon+L%3BWaldmann%2C+Thomas+A%3BPerera%2C+Liyanage+P&rft.aulast=Perera&rft.aufirst=Pin-Yu&rft.date=2009-03-26&rft.volume=27&rft.issue=15&rft.spage=2121&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2009.01.132 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Tuberculosis; Mycobacterium bovis DO - http://dx.doi.org/10.1016/j.vaccine.2009.01.132 ER - TY - JOUR T1 - An analysis of growth, differentiation and apoptosis genes with risk of renal cancer. AN - 67490974; 19603096 AB - We conducted a case-control study of renal cancer (987 cases and 1298 controls) in Central and Eastern Europe and analyzed genomic DNA for 319 tagging single-nucleotide polymorphisms (SNPs) in 21 genes involved in cellular growth, differentiation and apoptosis using an Illumina Oligo Pool All (OPA). A haplotype-based method (sliding window analysis of consecutive SNPs) was used to identify chromosome regions of interest that remained significant at a false discovery rate of 10%. Subsequently, risk estimates were generated for regions with a high level of signal and individual SNPs by unconditional logistic regression adjusting for age, gender and study center. Three regions containing genes associated with renal cancer were identified: caspase 1/5/4/12(CASP 1/5/4/12), epidermal growth factor receptor (EGFR), and insulin-like growth factor binding protein-3 (IGFBP3). We observed that individuals with CASP1/5/4/12 haplotype (spanning area upstream of CASP1 through exon 2 of CASP5) GGGCTCAGT were at higher risk of renal cancer compared to individuals with the most common haplotype (OR:1.40, 95% CI:1.10-1.78, p-value = 0.007). Analysis of EGFR revealed three strong signals within intron 1, particularly a region centered around rs759158 with a global p = 0.006 (GGG: OR:1.26, 95% CI:1.04-1.53 and ATG: OR:1.55, 95% CI:1.14-2.11). A region in IGFBP3 was also associated with increased risk (global p = 0.04). In addition, the number of statistically significant (p-value<0.05) SNP associations observed within these three genes was higher than would be expected by chance on a gene level. To our knowledge, this is the first study to evaluate these genes in relation to renal cancer and there is need to replicate and extend our findings. The specific regions associated with risk may have particular relevance for gene function and/or carcinogenesis. In conclusion, our evaluation has identified common genetic variants in CASP1, CASP5, EGFR, and IGFBP3 that could be associated with renal cancer risk. JF - PloS one AU - Dong, Linda M AU - Brennan, Paul AU - Karami, Sara AU - Hung, Rayjean J AU - Menashe, Idan AU - Berndt, Sonja I AU - Yeager, Meredith AU - Chanock, Stephen AU - Zaridze, David AU - Matveev, Vsevolod AU - Janout, Vladimir AU - Kollarova, Hellena AU - Bencko, Vladimir AU - Schwartz, Kendra AU - Davis, Faith AU - Navratilova, Marie AU - Szeszenia-Dabrowska, Neonila AU - Mates, Dana AU - Colt, Joanne S AU - Holcatova, Ivana AU - Boffetta, Paolo AU - Rothman, Nathaniel AU - Chow, Wong-Ho AU - Rosenberg, Philip S AU - Moore, Lee E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America. donglm@mail.nih.gov Y1 - 2009/03/24/ PY - 2009 DA - 2009 Mar 24 SP - 1 VL - 4 IS - 3 KW - Index Medicus KW - Genotype KW - Polymorphism, Single Nucleotide KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Genetic Predisposition to Disease KW - Cell Proliferation KW - Male KW - Female KW - Kidney Neoplasms -- genetics KW - Apoptosis -- genetics KW - Cell Differentiation -- genetics KW - Kidney Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67490974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=An+analysis+of+growth%2C+differentiation+and+apoptosis+genes+with+risk+of+renal+cancer.&rft.au=Dong%2C+Linda+M%3BBrennan%2C+Paul%3BKarami%2C+Sara%3BHung%2C+Rayjean+J%3BMenashe%2C+Idan%3BBerndt%2C+Sonja+I%3BYeager%2C+Meredith%3BChanock%2C+Stephen%3BZaridze%2C+David%3BMatveev%2C+Vsevolod%3BJanout%2C+Vladimir%3BKollarova%2C+Hellena%3BBencko%2C+Vladimir%3BSchwartz%2C+Kendra%3BDavis%2C+Faith%3BNavratilova%2C+Marie%3BSzeszenia-Dabrowska%2C+Neonila%3BMates%2C+Dana%3BColt%2C+Joanne+S%3BHolcatova%2C+Ivana%3BBoffetta%2C+Paolo%3BRothman%2C+Nathaniel%3BChow%2C+Wong-Ho%3BRosenberg%2C+Philip+S%3BMoore%2C+Lee+E&rft.aulast=Dong&rft.aufirst=Linda&rft.date=2009-03-24&rft.volume=4&rft.issue=3&rft.spage=e4895&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0004895 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-22 N1 - Date created - 2009-07-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Tohoku J Exp Med. 2002 Nov;198(3):181-90 [12597245] Endocr Rev. 2002 Dec;23(6):824-54 [12466191] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Kidney Int. 2004 Apr;65(4):1272-9 [15086466] J Pathol. 2004 May;203(1):545-50 [15095477] Lancet. 2004 Apr 24;363(9418):1346-53 [15110491] Nat Rev Cancer. 2004 Jul;4(7):505-18 [15229476] Science. 1991 Nov 22;254(5035):1146-53 [1659742] Hum Mol Genet. 1992 May;1(2):135 [1301150] J Biol Chem. 1994 Apr 22;269(16):12032-9 [8163506] Eur Urol. 2007 Oct;52(4):1147-55 [17287073] J Clin Endocrinol Metab. 2007 Sep;92(9):3660-6 [17566087] Carcinogenesis. 2007 Sep;28(9):1960-4 [17617661] J Urol. 2008 Feb;179(2):445-9 [18076934] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] BJU Int. 2008 Apr;101(8):949-58 [18241251] Cancer Res. 2008 Apr 15;68(8):3037-42 [18413774] Cancer Cell. 2008 May;13(5):385-93 [18455122] Hum Pathol. 2008 Jun;39(6):895-900 [18430458] Eur J Cancer. 2008 Jul;44(10):1345-89 [18280139] PLoS One. 2008;3(7):e2578 [18596909] Carcinogenesis. 2008 Oct;29(10):1938-43 [18676680] Cancer J. 2008 Sep-Oct;14(5):288-301 [18836333] Carcinogenesis. 2008 Nov;29(11):2112-9 [18711149] Br J Urol. 1996 Oct;78(4):542-5 [8944511] Science. 1998 Aug 28;281(5381):1312-6 [9721091] Cancer Res. 2005 Jan 1;65(1):46-53 [15665278] Mol Cancer Res. 2005 May;3(5):251-60 [15886296] Ann Oncol. 2005 Nov;16(11):1740-8 [15980157] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Gene. 2006 Jan 17;366(1):2-16 [16377102] Trends Genet. 2006 Mar;22(3):119-22 [16430990] Dis Colon Rectum. 2006 Mar;49(3):399-406 [16421660] Cancer Res. 2006 May 15;66(10):5021-8 [16707423] Stat Med. 2006 Sep 30;25(18):3134-49 [16252274] J Natl Cancer Inst. 2006 Oct 4;98(19):1382-96 [17018785] Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1993-7 [17035411] Kidney Int. 2006 Nov;70(9):1584-90 [16969385] Cell Death Differ. 2007 Jan;14(1):10-22 [16977329] Oncologist. 2007 Feb;12(2):201-10 [17296816] Cell Death Differ. 1999 Nov;6(11):1028-42 [10578171] Cell. 2000 Jan 7;100(1):57-70 [10647931] Int J Biol Markers. 2000 Jan-Mar;15(1):105-10 [10763151] Hum Genet. 2001 Aug;109(2):146-51 [11511919] Eur J Cancer Prev. 2002 Apr;11(2):171-8 [11984136] Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):513-20 [12050091] Int J Mol Med. 2003 Oct;12(4):443-6 [12964016] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0004895 ER - TY - JOUR T1 - The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. AN - 67085399; 19320537 JF - PLoS medicine AU - Brooks, Philip J AU - Enoch, Mary-Anne AU - Goldman, David AU - Li, Ting-Kai AU - Yokoyama, Akira AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, United States of America. pjbrooks@mail.nih.gov Y1 - 2009/03/24/ PY - 2009 DA - 2009 Mar 24 SP - 1 VL - 6 IS - 3 KW - Ethanol KW - 3K9958V90M KW - ALDH2 protein, human KW - EC 1.2.1.3 KW - Aldehyde Dehydrogenase KW - Aldehyde Dehydrogenase, Mitochondrial KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - DNA Damage KW - Humans KW - Social Behavior KW - Acetaldehyde -- metabolism KW - Asian Continental Ancestry Group -- genetics KW - Far East -- epidemiology KW - Patient Education as Topic KW - Alcoholism -- epidemiology KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Genetic Predisposition to Disease KW - Early Diagnosis KW - Esophageal Neoplasms -- prevention & control KW - Esophageal Neoplasms -- chemically induced KW - Aldehyde Dehydrogenase -- genetics KW - Carcinoma, Squamous Cell -- epidemiology KW - Alcohol Drinking -- adverse effects KW - Carcinoma, Squamous Cell -- chemically induced KW - Flushing -- ethnology KW - Flushing -- genetics KW - Esophageal Neoplasms -- epidemiology KW - Carcinoma, Squamous Cell -- ethnology KW - Ethanol -- adverse effects KW - Ethanol -- pharmacokinetics KW - Esophageal Neoplasms -- ethnology KW - Aldehyde Dehydrogenase -- physiology KW - Esophageal Neoplasms -- genetics KW - Alcohol Drinking -- psychology KW - Carcinoma, Squamous Cell -- genetics KW - Carcinoma, Squamous Cell -- prevention & control KW - Flushing -- chemically induced KW - Aldehyde Dehydrogenase -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67085399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+medicine&rft.atitle=The+alcohol+flushing+response%3A+an+unrecognized+risk+factor+for+esophageal+cancer+from+alcohol+consumption.&rft.au=Brooks%2C+Philip+J%3BEnoch%2C+Mary-Anne%3BGoldman%2C+David%3BLi%2C+Ting-Kai%3BYokoyama%2C+Akira&rft.aulast=Brooks&rft.aufirst=Philip&rft.date=2009-03-24&rft.volume=6&rft.issue=3&rft.spage=e50&rft.isbn=&rft.btitle=&rft.title=PLoS+medicine&rft.issn=1549-1676&rft_id=info:doi/10.1371%2Fjournal.pmed.1000050 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-08 N1 - Date created - 2009-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):15S-32S [11391045] Alcohol Clin Exp Res. 2000 Jun;24(6):873-7 [10888077] Jpn J Clin Oncol. 2003 Mar;33(3):111-21 [12672787] Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1227-33 [14652286] Proc Nutr Soc. 2004 Feb;63(1):49-63 [15099407] Clin Genet. 1979 Jul;16(1):29-33 [477012] Lancet. 1981 Oct 31;2(8253):982 [6117742] Lancet. 1982 Oct 9;2(8302):827 [6126701] Proc Natl Acad Sci U S A. 1984 Jan;81(1):258-61 [6582480] Am J Epidemiol. 1985 Nov;122(5):904-14 [4050778] Mutat Res. 1988 Jan;195(1):1-20 [3122032] Alcohol Clin Exp Res. 1989 Apr;13(2):229-31 [2658661] Lancet. 1994 Mar 19;343(8899):741-2 [7907720] Cancer Epidemiol Biomarkers Prev. 1996 Feb;5(2):99-102 [8850269] Am J Hum Genet. 1999 Sep;65(3):795-807 [10441588] Alcohol. 2005 Apr;35(3):187-93 [16054980] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1967-71 [16103445] Endoscopy. 2006 Feb;38(2):149-56 [16479422] Alcohol Clin Exp Res. 2006 Mar;30(3):491-500 [16499490] Chem Res Toxicol. 2006 Oct;19(10):1374-8 [17040107] Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2209-15 [17119048] Mutat Res. 2007 Feb 3;615(1-2):134-42 [17207821] Lancet Oncol. 2007 Apr;8(4):292-3 [17431955] Eur J Cancer. 2007 May;43(7):1188-99 [17383866] Nat Rev Cancer. 2007 Aug;7(8):599-612 [17646865] Alcohol Res Health. 2007;30(1):22-7 [17718397] World J Gastroenterol. 2007 Nov 21;13(43):5760-4 [17963305] Int J Cancer. 2008 Mar 15;122(6):1347-56 [18033686] Hum Mol Genet. 2008 Mar 15;17(6):854-8 [18056758] Food Chem Toxicol. 2008 Aug;46(8):2903-11 [18577414] Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2846-54 [18843030] Nat Clin Pract Gastroenterol Hepatol. 2008 Sep;5(9):517-26 [18679388] Carcinogenesis. 2000 Apr;21(4):663-8 [10753201] Carcinogenesis. 2002 Nov;23(11):1851-9 [12419833] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pmed.1000050 ER - TY - JOUR T1 - Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats. AN - 67094073; 19309499 AB - There is experimental evidence from animal models favoring the notion that the disruption of interactions between stroma and epithelium plays an important role in the initiation of carcinogenesis. These disrupted interactions are hypothesized to be mediated by molecules, termed morphostats, which diffuse through the tissue to determine cell phenotype and maintain tissue architecture. We developed a computer simulation based on simple properties of cell renewal and morphostats. Under the computer simulation, the disruption of the morphostat gradient in the stroma generated epithelial precursors of cancer without any mutation in the epithelium. The model is consistent with the possibility that the accumulation of genetic and epigenetic changes found in tumors could arise after the formation of a founder population of aberrant cells, defined as cells that are created by low or insufficient morphostat levels and that no longer respond to morphostat concentrations. Because the model is biologically plausible, we hope that these results will stimulate further experiments. JF - BMC cancer AU - Baker, Stuart G AU - Soto, Ana M AU - Sonnenschein, Carlos AU - Cappuccio, Antonio AU - Potter, John D AU - Kramer, Barnett S AD - Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, USA. sb16i@nih.gov Y1 - 2009/03/23/ PY - 2009 DA - 2009 Mar 23 SP - 89 VL - 9 KW - Index Medicus KW - Phenotype KW - Animals KW - Neoplasms -- pathology KW - Cell Polarity KW - Humans KW - Morphogenesis KW - Cell Differentiation KW - Cell Communication KW - Mutation KW - Neoplasms -- genetics KW - Neoplasms -- etiology KW - Models, Theoretical KW - Epithelial Cells -- metabolism KW - Computer Simulation KW - Epithelial Cells -- pathology KW - Cell Transformation, Neoplastic -- metabolism KW - Stromal Cells -- metabolism KW - Stromal Cells -- pathology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67094073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Plausibility+of+stromal+initiation+of+epithelial+cancers+without+a+mutation+in+the+epithelium%3A+a+computer+simulation+of+morphostats.&rft.au=Baker%2C+Stuart+G%3BSoto%2C+Ana+M%3BSonnenschein%2C+Carlos%3BCappuccio%2C+Antonio%3BPotter%2C+John+D%3BKramer%2C+Barnett+S&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2009-03-23&rft.volume=9&rft.issue=&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/10.1186%2F1471-2407-9-89 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-06 N1 - Date created - 2009-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Cell. 2005 Jan;7(1):17-23 [15652746] Am J Anat. 1965 Jul;117:73-87 [14345836] Math Med Biol. 2005 Jun;22(2):163-86 [15781426] J Neurobiol. 2005 Sep 15;64(4):458-75 [16041741] Semin Cancer Biol. 2005 Dec;15(6):423-35 [16043359] J Natl Cancer Inst. 2005 Nov 16;97(22):1652-62 [16288118] Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14140-5 [16966602] Cell. 2006 Nov 3;127(3):469-80 [17081971] Cancer Cell. 2007 Feb;11(2):109-17 [17292823] Nat Rev Cancer. 2007 Jun;7(6):464-74 [17522715] Neuroimage. 2007;37 Suppl 1:S120-34 [17629503] BMC Cancer. 2007;7:151 [17683619] N Engl J Med. 2008 Jan 31;358(5):502-11 [18234754] Nat Genet. 2008 May;40(5):650-5 [18408720] Cancer Res. 2008 May 15;68(10):3551-7; discussion 3557 [18483233] Br J Cancer. 2008 Jul 8;99(1):143-50 [18577996] J Natl Cancer Inst. 1967 Oct;39(4):663-79 [18623928] Semin Cancer Biol. 2008 Oct;18(5):372-7 [18472276] Development. 1999 Dec;126(23):5309-17 [10556056] Carcinogenesis. 2000 Mar;21(3):397-404 [10688860] Cancer Res. 2000 Mar 1;60(5):1254-60 [10728684] Cell. 2000 Oct 13;103(2):311-20 [11057903] Cancer Epidemiol Biomarkers Prev. 2001 Mar;10(3):161-70 [11303583] Nature. 2001 Oct 25;413(6858):797-803 [11677596] Nat Rev Cancer. 2001 Oct;1(1):46-54 [11900251] Nat Rev Cancer. 2004 Mar;4(3):197-205 [14993901] J Cell Sci. 2004 Mar 15;117(Pt 8):1495-502 [14996910] Bioessays. 2004 Oct;26(10):1097-107 [15382143] Int J Cancer. 1966 Sep 15;1(5):419-50 [4287947] Nature. 1971 Sep 24;233(5317):267-8 [4938366] J Natl Cancer Inst. 1973 Oct;51(4):1275-85 [4583375] Cancer Res. 1973 Dec;33(12):3139-54 [4357350] J Theor Biol. 1982 Nov 7;99(1):31-68 [6892044] Cell. 1986 May 23;45(4):485-95 [3011271] Oncogene. 1993 Jun;8(6):1551-8 [8099220] Cancer Res. 1994 Oct 15;54(20):5296-300 [7923156] Int J Radiat Biol. 1996 Feb;69(2):175-82 [8609453] Curr Biol. 1997 Sep 1;7(9):671-81 [9285724] Curr Opin Cell Biol. 1998 Oct;10(5):647-53 [9818176] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15333-8 [9860969] Natl Cancer Inst Monogr. 1964 May;14:119-50 [14147128] Prog Exp Tumor Res. 1964;5:85-133 [14317768] Cell Res. 2005 Jan;15(1):28-32 [15686623] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2407-9-89 ER - TY - CPAPER T1 - Parkin Scavenges Damaged Mitochondria T2 - 2009 Keystone Symposia on Mitochondrial Dynamics and Physiology (X6) AN - 41939459; 5113504 JF - 2009 Keystone Symposia on Mitochondrial Dynamics and Physiology (X6) AU - Tanaka, Atsushi Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Mitochondria KW - Parkin protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41939459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Mitochondrial+Dynamics+and+Physiology+%28X6%29&rft.atitle=Parkin+Scavenges+Damaged+Mitochondria&rft.au=Tanaka%2C+Atsushi&rft.aulast=Tanaka&rft.aufirst=Atsushi&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Mitochondrial+Dynamics+and+Physiology+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=97 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 3D Architecture of the Virological Synapse and Structural Mechanisms of HIV Entry T2 - 2009 Keystone Symposia on HIV Immunobiology: From Infection to Immune Control (X4) AN - 41926989; 5114647 JF - 2009 Keystone Symposia on HIV Immunobiology: From Infection to Immune Control (X4) AU - Subramaniam, Sriram Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Human immunodeficiency virus KW - Synapses KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41926989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+HIV+Immunobiology%3A+From+Infection+to+Immune+Control+%28X4%29&rft.atitle=3D+Architecture+of+the+Virological+Synapse+and+Structural+Mechanisms+of+HIV+Entry&rft.au=Subramaniam%2C+Sriram&rft.aulast=Subramaniam&rft.aufirst=Sriram&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+HIV+Immunobiology%3A+From+Infection+to+Immune+Control+%28X4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunogenetic Variation Characterizing Exceptional Control of HIV T2 - 2009 Keystone Symposia on HIV Immunobiology: From Infection to Immune Control (X4) AN - 41926813; 5114600 JF - 2009 Keystone Symposia on HIV Immunobiology: From Infection to Immune Control (X4) AU - Carrington, Mary Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Human immunodeficiency virus KW - Immunogenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41926813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+HIV+Immunobiology%3A+From+Infection+to+Immune+Control+%28X4%29&rft.atitle=Immunogenetic+Variation+Characterizing+Exceptional+Control+of+HIV&rft.au=Carrington%2C+Mary&rft.aulast=Carrington&rft.aufirst=Mary&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+HIV+Immunobiology%3A+From+Infection+to+Immune+Control+%28X4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effective Control of HIV by CD8+ T-Cells is Associated with Infected CD4+ T Cell Elimination: Ramifications for T Cell Based Vaccines T2 - 2009 Keystone Symposia on HIV Immunobiology: From Infection to Immune Control (X4) AN - 41925010; 5114610 JF - 2009 Keystone Symposia on HIV Immunobiology: From Infection to Immune Control (X4) AU - Connors, Mark Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Human immunodeficiency virus KW - Vaccines KW - Lymphocytes T KW - CD8 antigen KW - CD4 antigen KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41925010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+HIV+Immunobiology%3A+From+Infection+to+Immune+Control+%28X4%29&rft.atitle=Effective+Control+of+HIV+by+CD8%2B+T-Cells+is+Associated+with+Infected+CD4%2B+T+Cell+Elimination%3A+Ramifications+for+T+Cell+Based+Vaccines&rft.au=Connors%2C+Mark&rft.aulast=Connors&rft.aufirst=Mark&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+HIV+Immunobiology%3A+From+Infection+to+Immune+Control+%28X4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The characterisation of ABCB5 reveals a full length transporter mediating multidrug resistance T2 - 2009 Gordon Research Conference on Multi-Drug Efflux Systems AN - 41919183; 5115520 JF - 2009 Gordon Research Conference on Multi-Drug Efflux Systems AU - Gillet, Jean-Pierre Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Multidrug resistance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41919183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Multi-Drug+Efflux+Systems&rft.atitle=The+characterisation+of+ABCB5+reveals+a+full+length+transporter+mediating+multidrug+resistance&rft.au=Gillet%2C+Jean-Pierre&rft.aulast=Gillet&rft.aufirst=Jean-Pierre&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Multi-Drug+Efflux+Systems&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=multidrug LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of HIV-1 Nuclear Entry T2 - 2009 Keystone Symposia on HIV Immunobiology: From Infection to Immune Control (X4) AN - 41918769; 5114634 JF - 2009 Keystone Symposia on HIV Immunobiology: From Infection to Immune Control (X4) AU - KewalRamani, Vineet Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41918769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+HIV+Immunobiology%3A+From+Infection+to+Immune+Control+%28X4%29&rft.atitle=Regulation+of+HIV-1+Nuclear+Entry&rft.au=KewalRamani%2C+Vineet&rft.aulast=KewalRamani&rft.aufirst=Vineet&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+HIV+Immunobiology%3A+From+Infection+to+Immune+Control+%28X4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of eukaryotic multidrug transporters T2 - 2009 Gordon Research Conference on Multi-Drug Efflux Systems AN - 41913889; 5115513 JF - 2009 Gordon Research Conference on Multi-Drug Efflux Systems AU - Gottesman, Michael Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41913889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Multi-Drug+Efflux+Systems&rft.atitle=Overview+of+eukaryotic+multidrug+transporters&rft.au=Gottesman%2C+Michael&rft.aulast=Gottesman&rft.aufirst=Michael&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Multi-Drug+Efflux+Systems&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=multidrug LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drug interactions and multidrug efflux pumps T2 - 2009 Gordon Research Conference on Multi-Drug Efflux Systems AN - 41908138; 5115556 JF - 2009 Gordon Research Conference on Multi-Drug Efflux Systems AU - Figg, William AU - Sissung, Tristan Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Drug interaction KW - Pumps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41908138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Multi-Drug+Efflux+Systems&rft.atitle=Drug+interactions+and+multidrug+efflux+pumps&rft.au=Figg%2C+William%3BSissung%2C+Tristan&rft.aulast=Figg&rft.aufirst=William&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Multi-Drug+Efflux+Systems&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=multidrug LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV at the Mucosa: Portal of Entry and Front-Line Defense T2 - 2009 Keystone Symposia on Prevention of HIV/AIDS (X3) AN - 41906537; 5114730 JF - 2009 Keystone Symposia on Prevention of HIV/AIDS (X3) AU - Douek, Daniel AU - Haase, Ashley AU - Simmons, Alison AU - Veazey, Ronald AU - Dandekar, Satya Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Human immunodeficiency virus KW - Mucosa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41906537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Prevention+of+HIV%2FAIDS+%28X3%29&rft.atitle=HIV+at+the+Mucosa%3A+Portal+of+Entry+and+Front-Line+Defense&rft.au=Douek%2C+Daniel%3BHaase%2C+Ashley%3BSimmons%2C+Alison%3BVeazey%2C+Ronald%3BDandekar%2C+Satya&rft.aulast=Douek&rft.aufirst=Daniel&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Prevention+of+HIV%2FAIDS+%28X3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mitochondrial Morphogenesis and Apoptosis T2 - 2009 Keystone Symposia on Mitochondrial Dynamics and Physiology (X6) AN - 41905295; 5113461 JF - 2009 Keystone Symposia on Mitochondrial Dynamics and Physiology (X6) AU - Youle, Richard Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Mitochondria KW - Apoptosis KW - Morphogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41905295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Mitochondrial+Dynamics+and+Physiology+%28X6%29&rft.atitle=Mitochondrial+Morphogenesis+and+Apoptosis&rft.au=Youle%2C+Richard&rft.aulast=Youle&rft.aufirst=Richard&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Mitochondrial+Dynamics+and+Physiology+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=97 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Which Immune Correlates of Protection against HIV? How to Measure T Cell and B Cell Correlates? Supported in part by the French Agency for AIDS Research (ANRS) T2 - 2009 Keystone Symposia on Prevention of HIV/AIDS (X3) AN - 41894517; 5114729 JF - 2009 Keystone Symposia on Prevention of HIV/AIDS (X3) AU - Koup, Richard AU - Saez-Cirion, Asier AU - Hersperger, Adam AU - Genesca, Meritxell AU - Almeida, Jorge AU - Stamatatos, Leonidas AU - Doria-Rose, Nicole AU - Hessell, Ann AU - Holl, Vincent Y1 - 2009/03/22/ PY - 2009 DA - 2009 Mar 22 KW - Human immunodeficiency virus KW - Acquired immune deficiency syndrome KW - Lymphocytes B KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41894517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Prevention+of+HIV%2FAIDS+%28X3%29&rft.atitle=Which+Immune+Correlates+of+Protection+against+HIV%3F+How+to+Measure+T+Cell+and+B+Cell+Correlates%3F+Supported+in+part+by+the+French+Agency+for+AIDS+Research+%28ANRS%29&rft.au=Koup%2C+Richard%3BSaez-Cirion%2C+Asier%3BHersperger%2C+Adam%3BGenesca%2C+Meritxell%3BAlmeida%2C+Jorge%3BStamatatos%2C+Leonidas%3BDoria-Rose%2C+Nicole%3BHessell%2C+Ann%3BHoll%2C+Vincent&rft.aulast=Koup&rft.aufirst=Richard&rft.date=2009-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Prevention+of+HIV%2FAIDS+%28X3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione. AN - 67032498; 19117944 AB - ATP-binding cassette transporters play an important role in drug resistance and nutrient transport. In the human malaria parasite Plasmodium falciparum, a homolog of the human p-glycoprotein (PfPgh-1) was shown to be involved in resistance to several drugs. More recently, many transporters were associated with higher IC(50) levels in responses to chloroquine (CQ) and quinine (QN) in field isolates. Subsequent studies, however, could not confirm the associations, although inaccuracy in drug tests in the later studies could contribute to the lack of associations. Here we disrupted a gene encoding a putative multidrug resistance-associated protein (PfMRP) that was previously shown to be associated with P. falciparum responses to CQ and QN. Parasites with disrupted PfMRP (W2/MRPDelta) could not grow to a parasitemia higher than 5% under normal culture conditions, possibly because of lower efficiency in removing toxic metabolites. The W2/MRPDelta parasite also accumulated more radioactive glutathione, CQ, and QN and became more sensitive to multiple antimalarial drugs, including CQ, QN, artemisinin, piperaquine, and primaquine. PfMRP was localized on the parasite surface membrane, within membrane-bound vesicles, and along the straight side of the D-shaped stage II gametocytes. The results suggest that PfMRP plays a role in the efflux of glutathione, CQ, and QN and contributes to parasite responses to multiple antimalarial drugs, possibly by pumping drugs outside the parasite. JF - The Journal of biological chemistry AU - Raj, Dipak Kumar AU - Mu, Jianbing AU - Jiang, Hongying AU - Kabat, Juraj AU - Singh, Subash AU - Sullivan, Margery AU - Fay, Michael P AU - McCutchan, Thomas F AU - Su, Xin-Zhuan AD - Laboratory of Malaria and Vector Research, Research Technologies Branch, and Biostatistical Research Branch, NIAID, National Institutes of Health, Bethesda, Maryland 20892-8132, USA. Y1 - 2009/03/20/ PY - 2009 DA - 2009 Mar 20 SP - 7687 EP - 7696 VL - 284 IS - 12 SN - 0021-9258, 0021-9258 KW - Antimalarials KW - 0 KW - Multidrug Resistance-Associated Proteins KW - Protozoan Proteins KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Gene Knockout Techniques KW - Animals KW - Humans KW - Cell Membrane -- genetics KW - Biological Transport -- genetics KW - Cell Membrane -- metabolism KW - Biological Transport -- drug effects KW - Protozoan Proteins -- metabolism KW - Antimalarials -- pharmacology KW - Antimalarials -- metabolism KW - Plasmodium falciparum -- genetics KW - Glutathione -- metabolism KW - Multidrug Resistance-Associated Proteins -- metabolism KW - Multidrug Resistance-Associated Proteins -- genetics KW - Protozoan Proteins -- genetics KW - Plasmodium falciparum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67032498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Disruption+of+a+Plasmodium+falciparum+multidrug+resistance-associated+protein+%28PfMRP%29+alters+its+fitness+and+transport+of+antimalarial+drugs+and+glutathione.&rft.au=Raj%2C+Dipak+Kumar%3BMu%2C+Jianbing%3BJiang%2C+Hongying%3BKabat%2C+Juraj%3BSingh%2C+Subash%3BSullivan%2C+Margery%3BFay%2C+Michael+P%3BMcCutchan%2C+Thomas+F%3BSu%2C+Xin-Zhuan&rft.aulast=Raj&rft.aufirst=Dipak&rft.date=2009-03-20&rft.volume=284&rft.issue=12&rft.spage=7687&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M806944200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-14 N1 - Date created - 2009-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Microbiol. 2004 May;52(4):985-97 [15130119] Mol Microbiol. 2008 Nov;70(4):786-98 [18713316] Lancet. 2004 Jul 31-Aug 6;364(9432):438-47 [15288742] Biochem Biophys Res Commun. 2004 Aug 13;321(1):197-201 [15358235] Mol Biol Evol. 2004 Nov;21(11):2149-60 [15297601] Science. 1976 Aug 20;193(4254):673-5 [781840] J Parasitol. 1979 Jun;65(3):418-20 [383936] Science. 1989 Jun 9;244(4909):1184-6 [2658061] Cell. 1989 Jun 16;57(6):921-30 [2701941] Nature. 1990 May 17;345(6272):255-8 [2185424] J Cell Biol. 1991 Jun;113(5):1033-42 [1674943] Exp Parasitol. 1994 Sep;79(2):137-47 [7914495] Trends Microbiol. 1994 Oct;2(10):407-11 [7850210] Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1130-4 [8577727] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6 [9380737] Infect Immun. 1998 Jun;66(6):2969-75 [9596774] Exp Parasitol. 1998 Jun;89(2):262-5 [9635451] Biochem Pharmacol. 1998 Nov 15;56(10):1305-13 [9825729] Biochemistry. 2005 Mar 22;44(11):4426-33 [15766272] Antimicrob Agents Chemother. 2005 Jun;49(6):2180-8 [15917511] Mol Biochem Parasitol. 2005 Sep;143(1):67-79 [16005087] Mol Microbiol. 2005 Aug;57(4):913-26 [16091034] Annu Rev Genomics Hum Genet. 2005;6:123-42 [16124856] PLoS Biol. 2005 Oct;3(10):e335 [16144426] Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16813-8 [16275909] Vaccine. 2006 Jan 16;24(3):374-90 [16154670] Methods Enzymol. 2005;400:409-29 [16399363] Methods Enzymol. 2005;400:460-84 [16399365] FEBS Lett. 2006 Feb 13;580(4):1183-91 [16364309] FEBS Lett. 2006 Feb 13;580(4):1131-8 [16406363] Cancer Lett. 2006 Mar 8;234(1):62-72 [16337740] Malar J. 2006;5:24 [16569231] Science. 1999 Nov 12;286(5443):1351-3 [10558988] Biosci Rep. 1999 Aug;19(4):293-300 [10589994] Parasitol Today. 2000 Mar;16(3):102-7 [10689328] Nature. 2000 Feb 24;403(6772):906-9 [10706290] Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2674-9 [10716995] Mol Microbiol. 2000 May;36(4):955-61 [10844681] J Natl Cancer Inst. 2000 Aug 16;92(16):1295-302 [10944550] Cancer Res. 2000 Oct 15;60(20):5761-6 [11059771] Parasitology. 2000 Jul;121 ( Pt 1):1-7 [11085219] Mol Cell. 2000 Oct;6(4):861-71 [11090624] Acta Biochim Pol. 2000;47(3):763-72 [11310975] Mol Pharmacol. 2002 Jan;61(1):35-42 [11752204] Biochim Biophys Acta. 2002 Feb 15;1559(2):171-8 [11853683] Nature. 2002 Jul 18;418(6895):320-3 [12124623] Nature. 2002 Oct 3;419(6906):498-511 [12368864] Mol Microbiol. 2003 Aug;49(4):977-89 [12890022] Science. 2003 Sep 12;301(5639):1503-8 [12893887] Redox Rep. 2003;8(5):276-9 [14962364] PLoS Biol. 2003 Oct;1(1):E5 [12929205] Antimicrob Agents Chemother. 2004 May;48(5):1803-6 [15105138] Curr Drug Targets. 2006 Aug;7(8):911-21 [16918320] J Biol Chem. 2006 Sep 15;281(37):27039-45 [16849328] Nat Rev Genet. 2007 Jul;8(7):497-506 [17572690] Parasitol Int. 2008 Mar;57(1):1-7 [17890140] Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20043-8 [18048320] Emerg Infect Dis. 2008 May;14(5):716-9 [18439351] Physiol Res. 2004;53(3):235-43 [15209530] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M806944200 ER - TY - JOUR T1 - p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities. AN - 67046009; 19151751 AB - DLC1 (deleted in liver cancer 1), which encodes a Rho GTPase-activating protein (Rho-GAP), is a potent tumor suppressor gene that is frequently inactivated in several human cancers. DLC1 is a multidomain protein that has been shown previously to bind members of the tensin gene family. Here we show that p120Ras-GAP (Ras-GAP; also known as RASA1) interacts and extensively colocalizes with DLC1 in focal adhesions. The binding was mapped to the SH3 domain located in the N terminus of Ras-GAP and to the Rho-GAP catalytic domain located in the C terminus of the DLC1. In vitro analyses with purified proteins determined that the isolated Ras-GAP SH3 domain inhibits DLC1 Rho-GAP activity, suggesting that Ras-GAP is a negative regulator of DLC1 Rho-GAP activity. Consistent with this possibility, we found that ectopic overexpression of Ras-GAP in a Ras-GAP-insensitive tumor line impaired the growth-suppressing activity of DLC1 and increased RhoA activity in vivo. Our observations expand the complexity of proteins that regulate DLC1 function and define a novel mechanism of the cross talk between Ras and Rho GTPases.1R01CA129610 JF - Oncogene AU - Yang, X-Y AU - Guan, M AU - Vigil, D AU - Der, C J AU - Lowy, D R AU - Popescu, N C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4262, USA. Y1 - 2009/03/19/ PY - 2009 DA - 2009 Mar 19 SP - 1401 EP - 1409 VL - 28 IS - 11 KW - DLC1 protein, human KW - 0 KW - GTPase-Activating Proteins KW - Tumor Suppressor Proteins KW - p120 GTPase Activating Protein KW - RHOA protein, human KW - 124671-05-2 KW - rhoA GTP-Binding Protein KW - EC 3.6.5.2 KW - Index Medicus KW - Humans KW - Catalytic Domain KW - Cell Line, Tumor KW - Cell Proliferation KW - src Homology Domains KW - Tumor Suppressor Proteins -- antagonists & inhibitors KW - rhoA GTP-Binding Protein -- metabolism KW - Neoplasms -- pathology KW - p120 GTPase Activating Protein -- analysis KW - Tumor Suppressor Proteins -- physiology KW - Tumor Suppressor Proteins -- analysis KW - p120 GTPase Activating Protein -- physiology KW - p120 GTPase Activating Protein -- chemistry KW - Tumor Suppressor Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67046009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=p120Ras-GAP+binds+the+DLC1+Rho-GAP+tumor+suppressor+protein+and+inhibits+its+RhoA+GTPase+and+growth-suppressing+activities.&rft.au=Yang%2C+X-Y%3BGuan%2C+M%3BVigil%2C+D%3BDer%2C+C+J%3BLowy%2C+D+R%3BPopescu%2C+N+C&rft.aulast=Yang&rft.aufirst=X-Y&rft.date=2009-03-19&rft.volume=28&rft.issue=11&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2008.498 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-01 N1 - Date created - 2009-03-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Oncol. 2008 Jun;32(6):1285-91 [18497990] Cancer Gene Ther. 2008 Jun;15(6):371-81 [18369381] PLoS One. 2008;3(8):e2902 [18682833] Science. 2008 Sep 26;321(5897):1801-6 [18772397] Cancer Res. 2008 Oct 1;68(19):7718-22 [18829524] J Biol Chem. 2008 Nov 21;283(47):32762-70 [18786931] Development. 2000 Nov;127(22):4891-903 [11044403] J Cell Biochem. 2001;84(1):173-87 [11746526] J Biol Chem. 2002 Jun 28;277(26):23742-6 [11976319] Adv Protein Chem. 2002;61:161-210 [12461824] Adv Protein Chem. 2002;61:211-68 [12461825] Oncogene. 2004 Feb 12;23(6):1308-13 [14647417] J Biol Chem. 2004 Mar 26;279(13):12883-9 [14707121] Nature. 1988 Sep 1;335(6185):90-3 [2842690] Science. 1988 Dec 23;242(4886):1697-700 [3201259] Nature. 1990 Aug 23;346(6286):754-6 [2201922] Curr Biol. 1995 Apr 1;5(4):364-7 [7542990] J Biol Chem. 1995 Jul 28;270(30):17947-52 [7629101] J Biol Chem. 1997 Jan 17;272(3):1677-81 [8999845] EMBO J. 1997 Feb 3;16(3):473-83 [9034330] Cell Signal. 1997 Feb;9(2):153-8 [9113414] Cancer Res. 1998 May 15;58(10):2196-9 [9605766] Mol Cell Biol. 1998 Sep;18(9):5567-78 [9710640] Mol Cell Biol. 1998 Nov;18(11):6729-36 [9774686] Oncogene. 1999 Aug 26;18(34):4884-9 [10490822] FEBS Lett. 2005 Feb 14;579(5):1191-6 [15710412] Biochem J. 2005 Sep 15;390(Pt 3):641-53 [16134966] Cancer Res. 2005 Oct 1;65(19):8861-8 [16204057] Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15207-12 [16217026] Methods. 2005 Oct;37(2):183-89 [16288887] Br J Cancer. 2006 Jan 30;94(2):318-22 [16421597] Cancer Res. 2006 Sep 1;66(17):8367-72 [16951145] Int J Oncol. 2006 Nov;29(5):1127-32 [17016643] Mol Biol Cell. 2006 Nov;17(11):4827-36 [16971514] Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8 [17188236] J Cell Biol. 2007 Jan 1;176(1):43-9 [17190795] Biochem Biophys Res Commun. 2007 Mar 30;355(1):72-7 [17292327] Mol Cancer Ther. 2007 Mar;6(3):820-32 [17339364] J Biol Chem. 2007 Mar 23;282(12):8801-11 [17272280] Proc Natl Acad Sci U S A. 2007 May 22;104(21):9012-7 [17517630] Oncogene. 2007 Jul 5;26(31):4580-9 [17297465] Nucleic Acids Res. 2007 Jul;35(Web Server issue):W451-4 [17485474] J Cell Mol Med. 2007 Sep-Oct;11(5):1185-207 [17979893] Biochem Biophys Res Commun. 2007 Dec 28;364(4):783-9 [17976533] Oncol Rep. 2008 Mar;19(3):669-74 [18288400] J Clin Oncol. 2008 Apr 1;26(10):1582-4 [18316790] Mol Carcinog. 2008 May;47(5):326-37 [17932950] Genes Dev. 2008 Jun 1;22(11):1439-44 [18519636] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2008.498 ER - TY - JOUR T1 - Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. AN - 67049494; 19293415 AB - Modafinil, a wake-promoting drug used to treat narcolepsy, is increasingly being used as a cognitive enhancer. Although initially launched as distinct from stimulants that increase extracellular dopamine by targeting dopamine transporters, recent preclinical studies suggest otherwise. To measure the acute effects of modafinil at doses used therapeutically (200 mg and 400 mg given orally) on extracellular dopamine and on dopamine transporters in the male human brain. Positron emission tomography with [(11)C]raclopride (D(2)/D(3) radioligand sensitive to changes in endogenous dopamine) and [(11)C]cocaine (dopamine transporter radioligand) was used to measure the effects of modafinil on extracellular dopamine and on dopamine transporters in 10 healthy male participants. The study took place over an 8-month period (2007-2008) at Brookhaven National Laboratory. Primary outcomes were changes in dopamine D(2)/D(3) receptor and dopamine transporter availability (measured by changes in binding potential) after modafinil when compared with after placebo. Modafinil decreased mean (SD) [(11)C]raclopride binding potential in caudate (6.1% [6.5%]; 95% confidence interval [CI], 1.5% to 10.8%; P = .02), putamen (6.7% [4.9%]; 95% CI, 3.2% to 10.3%; P = .002), and nucleus accumbens (19.4% [20%]; 95% CI, 5% to 35%; P = .02), reflecting increases in extracellular dopamine. Modafinil also decreased [(11)C]cocaine binding potential in caudate (53.8% [13.8%]; 95% CI, 43.9% to 63.6%; P < .001), putamen (47.2% [11.4%]; 95% CI, 39.1% to 55.4%; P < .001), and nucleus accumbens (39.3% [10%]; 95% CI, 30% to 49%; P = .001), reflecting occupancy of dopamine transporters. In this pilot study, modafinil blocked dopamine transporters and increased dopamine in the human brain (including the nucleus accumbens). Because drugs that increase dopamine in the nucleus accumbens have the potential for abuse, and considering the increasing use of modafinil, these results highlight the need for heightened awareness for potential abuse of and dependence on modafinil in vulnerable populations. JF - JAMA AU - Volkow, Nora D AU - Fowler, Joanna S AU - Logan, Jean AU - Alexoff, David AU - Zhu, Wei AU - Telang, Frank AU - Wang, Gene-Jack AU - Jayne, Millard AU - Hooker, Jacob M AU - Wong, Christopher AU - Hubbard, Barbara AU - Carter, Pauline AU - Warner, Donald AU - King, Payton AU - Shea, Colleen AU - Xu, Youwen AU - Muench, Lisa AU - Apelskog-Torres, Karen AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA. nvolkow@nida.nih.gov Y1 - 2009/03/18/ PY - 2009 DA - 2009 Mar 18 SP - 1148 EP - 1154 VL - 301 IS - 11 KW - Benzhydryl Compounds KW - 0 KW - Carbon Radioisotopes KW - Central Nervous System Stimulants KW - Dopamine Plasma Membrane Transport Proteins KW - Receptors, Dopamine D2 KW - Receptors, Dopamine D3 KW - Raclopride KW - 430K3SOZ7G KW - Cocaine KW - I5Y540LHVR KW - modafinil KW - R3UK8X3U3D KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Caudate Nucleus -- metabolism KW - Positron-Emission Tomography KW - Humans KW - Pilot Projects KW - Receptors, Dopamine D2 -- metabolism KW - Receptors, Dopamine D3 -- metabolism KW - Adult KW - Substance-Related Disorders KW - Putamen -- metabolism KW - Nucleus Accumbens -- metabolism KW - Middle Aged KW - Male KW - Central Nervous System Stimulants -- pharmacology KW - Brain -- drug effects KW - Benzhydryl Compounds -- pharmacology KW - Dopamine -- metabolism KW - Brain -- metabolism KW - Central Nervous System Stimulants -- administration & dosage KW - Brain -- diagnostic imaging KW - Benzhydryl Compounds -- administration & dosage KW - Dopamine Plasma Membrane Transport Proteins -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67049494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Effects+of+modafinil+on+dopamine+and+dopamine+transporters+in+the+male+human+brain%3A+clinical+implications.&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BLogan%2C+Jean%3BAlexoff%2C+David%3BZhu%2C+Wei%3BTelang%2C+Frank%3BWang%2C+Gene-Jack%3BJayne%2C+Millard%3BHooker%2C+Jacob+M%3BWong%2C+Christopher%3BHubbard%2C+Barbara%3BCarter%2C+Pauline%3BWarner%2C+Donald%3BKing%2C+Payton%3BShea%2C+Colleen%3BXu%2C+Youwen%3BMuench%2C+Lisa%3BApelskog-Torres%2C+Karen&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2009-03-18&rft.volume=301&rft.issue=11&rft.spage=1148&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/10.1001%2Fjama.2009.351 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2009-03-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Neuropharmacol. 2000 May-Jun;23(3):149-56 [10895398] Science. 2008 Dec 12;322(5908):1700-2 [19074351] J Neurosci. 2001 Mar 1;21(5):1787-94 [11222668] Neuroreport. 2001 Nov 16;12(16):3533-7 [11733706] Synapse. 2002 Mar 1;43(3):181-7 [11793423] Synapse. 2002 Jun 1;44(3):175-80 [11954049] Ann Clin Psychiatry. 2004 Apr-Jun;16(2):101-9 [15328903] Synapse. 1989;4(4):371-7 [2557686] J Cereb Blood Flow Metab. 1990 Sep;10(5):740-7 [2384545] Synapse. 1994 Apr;16(4):255-62 [8059335] J Cereb Blood Flow Metab. 1994 Nov;14(6):995-1010 [7929663] Nucl Med Biol. 1995 Oct;22(7):893-904 [8547887] Psychopharmacology (Berl). 1996 Aug;126(4):286-92 [8878344] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14128-33 [8943072] Biol Psychiatry. 1997 Dec 15;42(12):1181-3 [9426889] Am J Psychiatry. 1998 Oct;155(10):1325-31 [9766762] Acta Physiol Scand. 1963 Aug;58:292-305 [14078649] Neuropsychopharmacology. 2005 Jan;30(1):205-11 [15525998] Int Rev Neurobiol. 2005;63:1-20 [15797463] Psychopharmacology (Berl). 2005 Oct;182(1):186-93 [15986191] Nat Neurosci. 2005 Nov;8(11):1429-30 [16251981] Am J Psychiatry. 2006 Mar;163(3):549 [16513889] J Clin Psychiatry. 2006 May;67(5):727-35 [16841622] Pediatr Ann. 2006 Aug;35(8):552-6 [16986449] J Pharmacol Exp Ther. 2006 Nov;319(2):561-9 [16885432] Behav Brain Res. 2007 Jan 25;176(2):353-7 [17098298] J Clin Psychiatry. 2007 Jun;68(6):970-1; author reply 971-2 [17592927] Nature. 2007 Nov 15;450(7168):320 [18004327] Neuropsychopharmacology. 2008 Mar;33(4):761-8 [17568397] J Sleep Res. 2008 Mar;17(1):82-8 [18275558] Neuropsychopharmacology. 2008 Jun;33(7):1477-502 [17712350] J Neurosci. 2008 Aug 20;28(34):8462-9 [18716204] J Neurosci. 2000 Nov 15;20(22):8620-8 [11069971] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/jama.2009.351 ER - TY - JOUR T1 - ABO Blood Group and the Risk of Pancreatic Cancer AN - 20456208; 9146029 AB - Background Other than several rare, highly penetrant familial syndromes, genetic risk factors for sporadic pancreatic cancer are largely unknown. ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies.Methods We separately examined the relationship between ABO blood type and the risk of incident pancreatic cancer in two large, independent, prospective cohort studies (the Nurses' Health Study and Health Professionals Follow-up Study) that collected blood group data on 107503 US health professionals. Hazard ratios for pancreatic cancer by ABO blood type were calculated using Cox proportional hazards models with adjustment for other known risk factors, including age, tobacco use, body mass index, physical activity, and history of diabetes mellitus. All statistical tests were two-sided.Results During 927995 person-years of follow-up, 316 participants developed pancreatic cancer. ABO blood type was associated with the risk of developing pancreatic cancer (P =.004; log-rank test). Compared with participants with blood group O, those with blood groups A, AB, or B were more likely to develop pancreatic cancer (adjusted hazard ratios for incident pancreatic cancer were 1.32 [95% confidence interval {CI}=1.02 to 1.72], 1.51 [95% CI=1.02 to 2.23], and 1.72 [95% CI=1.25 to 2.38], respectively). The association between blood type and pancreatic cancer risk was nearly identical in the two cohorts (Pinteraction=.97). Overall, 17% of the pancreatic cancer cases were attributable to inheriting a non-O blood group (blood group A, B, or AB). The age-adjusted incidence rates for pancreatic cancer per 100000 person-years were 27 (95% CI=23 to 33) for participants with blood type O, 36 (95% CI=26 to 50) for those with blood type A, 41 (95% CI=31 to 56) for those with blood type AB, and 46 (95% CI=32 to 68) for those with blood type B.Conclusions In two large, independent populations, ABO blood type was statistically significantly associated with the risk of pancreatic cancer. Further studies are necessary to define the mechanisms by which ABO blood type or closely linked genetic variants may influence pancreatic cancer risk. JF - Journal of the National Cancer Institute AU - Wolpin, Brian M AU - Chan, Andrew T AU - Hartge, Patricia AU - Chanock, Stephen J AU - Kraft, Peter AU - Hunter, David J AU - Giovannucci, Edward L AU - Fuchs, Charles S AD - Affiliations of authors: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (BMW, CSF); Channing Laboratory (ATC, ELG, CSF), Department of Medicine (BMW, DJH, CSF), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA (ATC); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (PH, SJC); Department of Epidemiology (PK, DJH, ELG) and Department of Nutrition (DJH, ELG), Harvard School of Public Health, Boston, MA, bwolpin@partners.org Y1 - 2009/03/18/ PY - 2009 DA - 2009 Mar 18 SP - 424 EP - 431 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 101 IS - 6 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Historical account KW - pancreatic cancer KW - diabetes mellitus KW - Age KW - body mass KW - Tobacco KW - physical activity KW - nursing KW - Cancer KW - Medical personnel KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20456208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=ABO+Blood+Group+and+the+Risk+of+Pancreatic+Cancer&rft.au=Wolpin%2C+Brian+M%3BChan%2C+Andrew+T%3BHartge%2C+Patricia%3BChanock%2C+Stephen+J%3BKraft%2C+Peter%3BHunter%2C+David+J%3BGiovannucci%2C+Edward+L%3BFuchs%2C+Charles+S&rft.aulast=Wolpin&rft.aufirst=Brian&rft.date=2009-03-18&rft.volume=101&rft.issue=6&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Historical account; Age; diabetes mellitus; pancreatic cancer; body mass; Tobacco; physical activity; nursing; Medical personnel; Cancer DO - http://dx.doi.org/10.1093/jnci/djp020 ER - TY - JOUR T1 - Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan. AN - 67128669; 19361477 AB - Islet-associated protein 2 (IA-2) and IA-2beta are major autoantigens in type 1 diabetes and transmembrane proteins in dense core secretory vesicles (DCV) of neuroendocrine cells. The deletion of these genes results in a decrease in insulin secretion. The present study was initiated to test the hypothesis that this deletion not only affects the secretion of insulin, but has a more global effect on neuroendocrine secretion that leads to disturbances in behavior and learning. Measurement of neurotransmitters showed that norepinephrine, dopamine and 5-HT were significantly decreased in the brain of double knockout (DKO) mice (P<0.05 to <0.001). In tests evaluating anxiety-like behavior and conditioned-learning, the DKO mice showed a highly significant increase in anxiety-like behavior (P<0.01 to <0.001) and impairment of conditioned learning (P<0.01) as compared to WT mice. The DKO mice also displayed an increase in spontaneous and induced seizures (P<0.01) and age-related death. Contrary to the generally held view that IA-2 and IA-2beta are expressed exclusively in DCV, subcellular fractionation studies revealed that IA-2beta, but not IA-2, co-purifies with fractions rich in synaptic vesicles (SV), and that the secretion of dopamine, GABA and glutamate from the synaptosomes of the DKO mice was significantly decreased as was the number of SV (P<0.01). Taken together, these findings show that IA-2beta is present in both DCV and SV, and that the deletion of IA-2/IA-2beta has a global effect on the secretion of neurotransmitters. The impairment of secretion leads to behavioral and learning disturbances, seizures and reduced lifespan. JF - Neuroscience AU - Nishimura, T AU - Kubosaki, A AU - Ito, Y AU - Notkins, A L AD - Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4322, USA. Y1 - 2009/03/17/ PY - 2009 DA - 2009 Mar 17 SP - 427 EP - 437 VL - 159 IS - 2 SN - 0306-4522, 0306-4522 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Insulin KW - Neurotransmitter Agents KW - Synapsins KW - Protein Tyrosine Phosphatase, Non-Receptor Type 1 KW - EC 3.1.3.48 KW - Ptpn1 protein, mouse KW - Ptprn protein, mouse KW - Receptor-Like Protein Tyrosine Phosphatases, Class 8 KW - Pentylenetetrazole KW - WM5Z385K7T KW - Index Medicus KW - Animals KW - Age Factors KW - Neurons -- ultrastructure KW - Mice, Knockout KW - Biotinylation -- methods KW - Secretory Vesicles -- metabolism KW - Seizures -- genetics KW - Exploratory Behavior -- physiology KW - Secretory Vesicles -- drug effects KW - Male KW - Reaction Time -- genetics KW - Motor Activity -- genetics KW - Rotarod Performance Test -- methods KW - Seizures -- chemically induced KW - Antidepressive Agents, Second-Generation -- pharmacology KW - Neurons -- metabolism KW - Synaptic Vesicles -- metabolism KW - Synaptic Vesicles -- drug effects KW - Mice KW - Insulin -- secretion KW - Hindlimb Suspension -- physiology KW - Synapsins -- metabolism KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Synaptosomes -- metabolism KW - Female KW - Drinking -- genetics KW - Protein Tyrosine Phosphatase, Non-Receptor Type 1 -- deficiency KW - Neurotransmitter Agents -- secretion KW - Conditioning (Psychology) -- physiology KW - Behavior, Animal -- physiology KW - Brain -- ultrastructure KW - Brain -- secretion KW - Receptor-Like Protein Tyrosine Phosphatases, Class 8 -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67128669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Disturbances+in+the+secretion+of+neurotransmitters+in+IA-2%2FIA-2beta+null+mice%3A+changes+in+behavior%2C+learning+and+lifespan.&rft.au=Nishimura%2C+T%3BKubosaki%2C+A%3BIto%2C+Y%3BNotkins%2C+A+L&rft.aulast=Nishimura&rft.aufirst=T&rft.date=2009-03-17&rft.volume=159&rft.issue=2&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2009.01.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-17 N1 - Date created - 2009-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anal Biochem. 2000 Jan 1;277(1):143-53 [10610699] Diabetologia. 2008 Mar;51(3):488-92 [18193190] J Histochem Cytochem. 2001 Jun;49(6):767-76 [11373323] J Clin Invest. 2001 Nov;108(9):1247-52 [11696564] Diabetes. 2002 Jun;51(6):1842-50 [12031972] Neurochem Int. 2003 Jun;42(7):583-90 [12590941] Acta Pharmacol Sin. 2003 Oct;24(10):991-5 [14531940] Neurobiol Dis. 2004 Apr;15(3):500-9 [15056457] Proc Natl Acad Sci U S A. 2004 May 25;101(21):8186-91 [15148402] Diabetes. 2004 Jul;53(7):1684-91 [15220191] Eur J Neurosci. 2004 Aug;20(4):1051-8 [15305873] J Cell Biol. 1983 May;96(5):1374-88 [6404912] Psychopharmacology (Berl). 1985;85(3):367-70 [3923523] J Neurochem. 1988 Apr;50(4):1237-42 [2964510] Biochemistry. 1989 Jan 24;28(2):586-93 [2653424] Pharmacopsychiatry. 1990 Jul;23(4):187-94 [2116631] J Neurosci. 1993 Sep;13(9):3895-903 [8366350] DNA Cell Biol. 1994 May;13(5):505-14 [8024693] Neurosci Res. 1995 Jul;22(4):423-6 [7478307] Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2307-11 [8637868] EMBO J. 1996 May 1;15(9):2102-14 [8641276] Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6367-70 [8692821] J Biol Chem. 1996 Jul 26;271(30):18161-70 [8663434] Biochem Biophys Res Commun. 1996 Oct 14;227(2):581-8 [8878556] Mamm Genome. 1997 Dec;8(12):949-50 [9383296] Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14060-5 [9391152] Neuroscience. 1998 Dec;87(3):583-90 [9758225] Biol Psychiatry. 1999 Jul 15;46(2):212-20 [10418696] J Biol Chem. 2005 Jun 3;280(22):21418-26 [15799973] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8704-9 [15939893] Diabetes. 2005 Dec;54 Suppl 2:S46-51 [16306340] Endocrinology. 2006 Feb;147(2):811-5 [16269463] Nat Cell Biol. 2006 May;8(5):435-45 [16622421] J Clin Neurosci. 2006 Nov;13(9):934-8 [17085299] Cell. 2006 Nov 17;127(4):831-46 [17110340] Sci Am. 2007 Mar;296(3):72-9 [17348162] Clin Exp Immunol. 2007 Oct;150(1):49-60 [17725654] Diabetologia. 2000 Nov;43(11):1429-34 [11126414] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2009.01.022 ER - TY - JOUR T1 - Host cell-free growth of the Q fever bacterium Coxiella burnetii AN - 20236876; 10313637 AB - The inability to propagate obligate intracellular pathogens under axenic (host cell-free) culture conditions imposes severe experimental constraints that have negatively impacted progress in understanding pathogen virulence and disease mechanisms. Coxiella burnetii, the causative agent of human Q (Query) fever, is an obligate intracellular bacterial pathogen that replicates exclusively in an acidified, lysosome-like vacuole. To define conditions that support C. burnetii growth, we systematically evaluated the organism's metabolic requirements using expression microarrays, genomic reconstruction, and metabolite typing. This led to development of a complex nutrient medium that supported substantial growth (approximately 3 log sub(10)) of C. burnetii in a 2.5% oxygen environment. Importantly, axenically grown C. burnetii were highly infectious for Vero cells and exhibited developmental forms characteristic of in vivo grown organisms. Axenic cultivation of C. burnetii will facilitate studies of the organism's pathogenesis and genetics and aid development of Q fever preventatives such as an effective subunit vaccine. Furthermore, the systematic approach used here may be broadly applicable to development of axenic media that support growth of other medically important obligate intracellular pathogens. JF - Proceedings of the National Academy of Sciences, USA AU - Omsland, Anders AU - Cockrell, Diane C AU - Howe, Dale AU - Fischer, Elizabeth R AU - Virtaneva, Kimmo AU - Sturdevant, Daniel E AU - Porcella, Stephen F AU - Heinzen, Robert A Y1 - 2009/03/17/ PY - 2009 DA - 2009 Mar 17 SP - 4430 EP - 4434 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 11 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - axenic growth KW - metabolism KW - microaerophile KW - obligate intracellular pathogen KW - Bacteria KW - Vero cells KW - Cell culture KW - Metabolites KW - Nutrients KW - Pathogens KW - Virulence KW - Coxiella burnetii KW - Oxygen KW - Typing KW - Vacuoles KW - Vaccines KW - genomics KW - Q fever KW - Media (culture) KW - J 02310:Genetics & Taxonomy KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20236876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Host+cell-free+growth+of+the+Q+fever+bacterium+Coxiella+burnetii&rft.au=Omsland%2C+Anders%3BCockrell%2C+Diane+C%3BHowe%2C+Dale%3BFischer%2C+Elizabeth+R%3BVirtaneva%2C+Kimmo%3BSturdevant%2C+Daniel+E%3BPorcella%2C+Stephen+F%3BHeinzen%2C+Robert+A&rft.aulast=Omsland&rft.aufirst=Anders&rft.date=2009-03-17&rft.volume=106&rft.issue=11&rft.spage=4430&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0812074106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Vero cells; Nutrients; Metabolites; Cell culture; Pathogens; Virulence; Oxygen; Typing; Vacuoles; genomics; Vaccines; Q fever; Media (culture); Coxiella burnetii; Bacteria DO - http://dx.doi.org/10.1073/pnas.0812074106 ER - TY - JOUR T1 - Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells. AN - 67036280; 19276279 AB - Nonsteroidal anti-inflammatory drugs (NSAID) are promising chemopreventive agents against colon and other cancers. However, the molecular basis mediated by NSAIDs for chemoprevention has not been fully elucidated. Environmental carcinogens induce DNA mutation and cellular transformation; therefore, we examined the effect of NSAIDs on carcinogenesis mediated by the aryl hydrocarbon receptor signaling pathway. In this study, we investigated the activities of a new class of NSAIDs containing dithiolethione moieties (S-NSAID) on both arms of carcinogenesis. We investigated the effects of the S-NSAIDs, S-diclofenac and S-sulindac, on carcinogen activation and detoxification mechanisms in human hepatoma HepG2 and human colonic adenocarcinoma LS180 cells. We found that S-diclofenac and S-sulindac inhibited the activity and expression of the carcinogen activating enzymes, cytochromes P-450 (CYP) CYP1A1, CYP1B1, and CYP1A2. Inhibition was mediated by transcriptional regulation of the aryl hydrocarbon receptor (AhR) pathway. The S-NSAIDs down-regulated carcinogen-induced expression of CYP1A1 heterogeneous nuclear RNA, a measure of transcription rate. Both compounds blocked carcinogen-activated AhR from binding to the xenobiotic responsive element as shown by chromatin immunoprecipitation. S-diclofenac and S-sulindac inhibited carcinogen-induced CYP enzyme activity through direct inhibition as well as through decreased transcriptional activation of the AhR. S-sulindac induced expression of several carcinogen detoxification enzymes of the glutathione cycle including glutathione S-transferase A2, glutamate cysteine ligase catalytic subunit, glutamate cysteine ligase modifier subunit, and glutathione reductase. These results indicate that S-diclofenac and S-sulindac may serve as effective chemoprevention agents by favorably balancing the equation of carcinogen activation and detoxification mechanisms. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Bass, Sara E AU - Sienkiewicz, Pawel AU - Macdonald, Christopher J AU - Cheng, Robert Y S AU - Sparatore, Anna AU - Del Soldato, Piero AU - Roberts, David D AU - Moody, Terry W AU - Wink, David A AU - Yeh, Grace Chao AD - Basic Research Program, Science Applications International Corporation-Frederick, Inc., and Laboratory of Metabolism, National Cancer Institute-Frederick, Frederick, Maryland, USA. Y1 - 2009/03/15/ PY - 2009 DA - 2009 Mar 15 SP - 1964 EP - 1972 VL - 15 IS - 6 SN - 1078-0432, 1078-0432 KW - 2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester KW - 0 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Anticarcinogenic Agents KW - Polychlorinated Dibenzodioxins KW - RNA, Messenger KW - Receptors, Aryl Hydrocarbon KW - S-sulindac KW - Thiones KW - Diclofenac KW - 144O8QL0L1 KW - Sulindac KW - 184SNS8VUH KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Index Medicus KW - Liver Neoplasms -- pathology KW - Cytochrome P-450 CYP1A1 -- genetics KW - Colorectal Neoplasms -- pathology KW - Liver Neoplasms -- enzymology KW - Humans KW - Polychlorinated Dibenzodioxins -- pharmacology KW - RNA, Messenger -- analysis KW - Cell Line, Tumor KW - Colorectal Neoplasms -- enzymology KW - Cytochrome P-450 CYP1A1 -- antagonists & inhibitors KW - Receptors, Aryl Hydrocarbon -- antagonists & inhibitors KW - Diclofenac -- analogs & derivatives KW - Diclofenac -- pharmacology KW - Thiones -- pharmacology KW - Anticarcinogenic Agents -- pharmacology KW - Sulindac -- pharmacology KW - Sulindac -- analogs & derivatives KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67036280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Novel+dithiolethione-modified+nonsteroidal+anti-inflammatory+drugs+in+human+hepatoma+HepG2+and+colon+LS180+cells.&rft.au=Bass%2C+Sara+E%3BSienkiewicz%2C+Pawel%3BMacdonald%2C+Christopher+J%3BCheng%2C+Robert+Y+S%3BSparatore%2C+Anna%3BDel+Soldato%2C+Piero%3BRoberts%2C+David+D%3BMoody%2C+Terry+W%3BWink%2C+David+A%3BYeh%2C+Grace+Chao&rft.aulast=Bass&rft.aufirst=Sara&rft.date=2009-03-15&rft.volume=15&rft.issue=6&rft.spage=1964&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-08-1870 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-16 N1 - Date created - 2009-03-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biotechniques. 1996 Mar;20(3):470-7 [8679208] Cancer Res. 1985 Jan;45(1):1-8 [3880665] Toxicology. 2000 Apr 3;144(1-3):31-8 [10781868] Carcinogenesis. 2000 Jun;21(6):1149-55 [10837003] Life Sci. 2001 Mar 23;68(18):2141-50 [11324719] Mutat Res. 2001 Sep 1;480-481:305-15 [11506823] JAMA. 2001 Aug 22-29;286(8):954-9 [11509060] J Nutr. 2001 Nov;131(11 Suppl):3027S-33S [11694642] FASEB J. 2002 Nov;16(13):1792-8 [12409322] Annu Rev Pharmacol Toxicol. 2003;43:309-34 [12540743] J Biochem. 2003 May;133(5):583-92 [12801909] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10937-41 [12960371] Mol Cell Biol. 2003 Nov;23(21):7920-5 [14560034] Gut. 2003 Nov;52(11):1537-42 [14570719] Ann Med. 2003;35(7):476-87 [14649330] Cancer Res. 2004 Jan 1;64(1):429-34 [14729655] Methods Enzymol. 2004;382:414-23 [15047114] Food Chem Toxicol. 1986 May;24(5):405-15 [3744194] Toxicol Appl Pharmacol. 1988 May;93(3):442-51 [3130679] Free Radic Biol Med. 1990;9(1):79-90 [2210442] Arch Biochem Biophys. 1991 Oct;290(1):27-36 [1654865] Cancer Res. 1994 Apr 1;54(7 Suppl):1982s-1986s [8137324] Gastroenterology. 1994 Jul;107(1):173-9 [8020659] Toxicology. 1994 Sep 6;92(1-3):39-51 [7940568] Pharmacogenetics. 1994 Aug;4(4):219-22 [7987406] Dis Colon Rectum. 1995 Aug;38(8):813-30 [7634976] Biochem Biophys Res Commun. 1996 Jan 5;218(1):148-53 [8573121] Cancer Res. 1997 Jan 15;57(2):267-71 [9000566] Biochem Pharmacol. 1998 Jul 1;56(1):61-9 [9698089] Clin Cancer Res. 1995 Oct;1(10):1133-8 [9815904] Hum Mutat. 2005 Feb;25(2):196-206 [15643613] Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L391-9 [15863442] J Mol Cell Cardiol. 2006 Jan;40(1):119-30 [16325198] Mol Pharmacol. 2006 Jun;69(6):1924-30 [16505155] Gastroenterology. 2006 Jul;131(1):259-71 [16831608] Carcinogenesis. 2006 Aug;27(8):1586-92 [16531450] J Pharmacol Exp Ther. 2006 Oct;319(1):447-58 [16855178] Biochem Biophys Res Commun. 2006 Dec 15;351(2):485-91 [17069760] Gastroenterology. 2007 Jan;132(1):261-71 [17241876] J Physiol Pharmacol. 2006 Dec;57 Suppl 12:15-24 [17244951] Free Radic Biol Med. 2007 Mar 1;42(5):706-19 [17291994] Br J Pharmacol. 2007 May;151(1):63-72 [17351657] Am J Pathol. 2007 Nov;171(5):1538-48 [17823287] Shock. 2008 Jan;29(1):84-8 [17621252] Int J Cancer. 2008 Mar 1;122(5):990-8 [17985343] Br J Pharmacol. 2008 Jan;153(1):100-9 [17965734] Scand J Gastroenterol Suppl. 1996;220:124-7 [8898449] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-08-1870 ER - TY - CPAPER T1 - The Mouse Mammary Microenvironment Redirects Spermatogenic, Neural and Marrow Cells to a Mammary Epithelial Progenitor Cell Fate T2 - 2009 Keystone Symposia on Extrinsic Control of Tumor Genesis and Progression (C8) AN - 41907936; 5113271 JF - 2009 Keystone Symposia on Extrinsic Control of Tumor Genesis and Progression (C8) AU - Smith, Gilbert Y1 - 2009/03/15/ PY - 2009 DA - 2009 Mar 15 KW - Microenvironments KW - Neural stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41907936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Extrinsic+Control+of+Tumor+Genesis+and+Progression+%28C8%29&rft.atitle=The+Mouse+Mammary+Microenvironment+Redirects+Spermatogenic%2C+Neural+and+Marrow+Cells+to+a+Mammary+Epithelial+Progenitor+Cell+Fate&rft.au=Smith%2C+Gilbert&rft.aulast=Smith&rft.aufirst=Gilbert&rft.date=2009-03-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Extrinsic+Control+of+Tumor+Genesis+and+Progression+%28C8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=96 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Population-Specific Genetic Variants Control Human Sweet Taste Sensitivity T2 - 2009 Keystone Symposia on Chemical Senses: Receptors and Circuits (C7) AN - 41907468; 5115107 JF - 2009 Keystone Symposia on Chemical Senses: Receptors and Circuits (C7) AU - Drayna, Dennis Y1 - 2009/03/15/ PY - 2009 DA - 2009 Mar 15 KW - Sensitivity KW - Sweet taste KW - Taste KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41907468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Chemical+Senses%3A+Receptors+and+Circuits+%28C7%29&rft.atitle=Population-Specific+Genetic+Variants+Control+Human+Sweet+Taste+Sensitivity&rft.au=Drayna%2C+Dennis&rft.aulast=Drayna&rft.aufirst=Dennis&rft.date=2009-03-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Chemical+Senses%3A+Receptors+and+Circuits+%28C7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 05 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Messenger RNA for neuropeptide Y in the arcuate nucleus increases in parallel with plasma adrenocorticotropin during sepsis in the rat AN - 762277533; 13712885 AB - Loss of appetite occurs in the cecal ligation and puncture (CLP) model of sepsis in conjunction with the activation of central neural stress pathways. Neuropeptide Y (NPY) in the arcuate nucleus of the hypothalamus is upregulated by several stressors and is stimulatory to feeding. To examine the response of NPY messenger RNA in the arcuate nucleus to sepsis, we used biotinylated RNA probes and a quantitative non-isotopic in situ hybridization approach in cryo-preserved sections from rats made septic by CLP. The mRNA in arcuate neurons was upregulated from the first day after CLP. By the afternoon of the third day through the morning of the fourth day, the average grey level of NPY mRNA clusters was 30% greater after CLP than after sham surgery (P < 0.05), and the integrated optical density based on both the grey level and the amount of area with detectable mRNA was 60% greater after CLP than after sham surgery (P < 0.03). Both the average grey level and area with detectable staining were positively correlated to plasma ACTH (r = 0.953 and 0.917, respectively, n = 10 and P < 0.01 in each case). Thus sepsis increases the expression of the mRNA for NPY in the arcuate nucleus in proportion to the magnitude of the stress response. However, the suppression of feeding behavior in the CLP model suggests that sepsis activates additional mechanisms that negate the orexigenic contribution of the neuronal increase in NPY mRNA. JF - Neuroscience Letters AU - Carlson, Drew E AU - Le, WeiWei AU - Chiu, William C AU - Hoffman, Gloria E AD - Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA, carlsonde@mail.nih.gov Y1 - 2009/03/13/ PY - 2009 DA - 2009 Mar 13 SP - 146 EP - 150 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB UK VL - 452 IS - 2 SN - 0304-3940, 0304-3940 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Adrenocorticotropic hormone KW - mRNA KW - N:14830 KW - N3:11001 KW - J:02490 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762277533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+Letters&rft.atitle=Messenger+RNA+for+neuropeptide+Y+in+the+arcuate+nucleus+increases+in+parallel+with+plasma+adrenocorticotropin+during+sepsis+in+the+rat&rft.au=Carlson%2C+Drew+E%3BLe%2C+WeiWei%3BChiu%2C+William+C%3BHoffman%2C+Gloria+E&rft.aulast=Carlson&rft.aufirst=Drew&rft.date=2009-03-13&rft.volume=452&rft.issue=2&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Neuroscience+Letters&rft.issn=03043940&rft_id=info:doi/10.1016%2Fj.neulet.2009.01.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - mRNA DO - http://dx.doi.org/10.1016/j.neulet.2009.01.046 ER - TY - JOUR T1 - Hijacked DNA repair proteins and unchained DNA polymerases. AN - 66866845; 19008198 AB - Somatic hypermutation of immunoglobulin (Ig) genes occurs at a frequency that is a million times greater than the mutation in other genes. Mutations occur in variable genes to increase antibody affinity, and in switch regions before constant genes to cause switching from IgM to IgG. Hypermutation is initiated in activated B cells when the activation-induced deaminase protein deaminates cytosine in DNA to uracil. Uracils can be processed by either a mutagenic pathway to produce mutations or a non-mutagenic pathway to remove mutations. In the mutagenic pathway, we first studied the role of mismatch repair proteins, MSH2, MSH3, MSH6, PMS2 and MLH1, since they would recognize mismatches. The MSH2-MSH6 heterodimer is involved in hypermutation by binding to U:G and other mismatches generated during repair synthesis, but the other proteins are not necessary. Second, we analysed the role of low-fidelity DNA polymerases eta, iota and theta in synthesizing mutations, and conclude that polymerase eta is the dominant participant by generating mutations at A:T base pairs. In the non-mutagenic pathway, we examined the role of the Cockayne syndrome B protein that interacts with other repair proteins. Mice deficient in this protein had normal hypermutation and class switch recombination, showing that it is not involved. JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences AU - Saribasak, Huseyin AU - Rajagopal, Deepa AU - Maul, Robert W AU - Gearhart, Patricia J AD - Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009/03/12/ PY - 2009 DA - 2009 Mar 12 SP - 605 EP - 611 VL - 364 IS - 1517 KW - Antibodies KW - 0 KW - Uracil KW - 56HH86ZVCT KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - MutS DNA Mismatch-Binding Protein KW - EC 3.6.1.3 KW - Index Medicus KW - Animals KW - Uracil -- metabolism KW - Models, Genetic KW - Mutation -- genetics KW - Mice KW - MutS DNA Mismatch-Binding Protein -- metabolism KW - Somatic Hypermutation, Immunoglobulin -- genetics KW - Base Pair Mismatch -- genetics KW - Somatic Hypermutation, Immunoglobulin -- immunology KW - DNA-Directed DNA Polymerase -- metabolism KW - Antibodies -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66866845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.atitle=Hijacked+DNA+repair+proteins+and+unchained+DNA+polymerases.&rft.au=Saribasak%2C+Huseyin%3BRajagopal%2C+Deepa%3BMaul%2C+Robert+W%3BGearhart%2C+Patricia+J&rft.aulast=Saribasak&rft.aufirst=Huseyin&rft.date=2009-03-12&rft.volume=364&rft.issue=1517&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.issn=1471-2970&rft_id=info:doi/10.1098%2Frstb.2008.0188 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-27 N1 - Date created - 2009-01-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 2000 Feb 7;191(3):579-84 [10662804] DNA Repair (Amst). 2008 Sep 1;7(9):1603-8 [18485835] Nat Immunol. 2001 Jun;2(6):537-41 [11376341] J Immunol. 2001 Jul 1;167(1):327-35 [11418667] J Mol Biol. 2001 Sep 14;312(2):335-46 [11554790] Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14553-8 [11717399] J Immunol. 2002 Apr 15;168(8):3702-6 [11937519] Nature. 2002 Jul 4;418(6893):99-103 [12097915] Nature. 2002 Sep 5;419(6902):43-8 [12214226] Curr Biol. 2002 Oct 15;12(20):1748-55 [12401169] Eur J Immunol. 2002 Nov;32(11):3152-60 [12555660] J Exp Med. 2003 Aug 18;198(4):635-43 [12925679] J Exp Med. 2004 Jan 19;199(2):265-70 [14734526] Nat Immunol. 2004 Feb;5(2):224-9 [14716311] J Exp Med. 2004 Apr 5;199(7):917-24 [15051760] J Exp Med. 2004 Jul 5;200(1):47-59 [15238604] J Exp Med. 2004 Jul 5;200(1):61-8 [15238605] J Exp Med. 1998 Jun 1;187(11):1735-43 [9607915] J Exp Med. 1998 Jun 1;187(11):1745-51 [9607916] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6953-8 [9618520] Immunity. 1998 Jul;9(1):127-34 [9697842] Immunity. 1998 Jul;9(1):135-41 [9697843] J Immunol. 1999 Mar 15;162(6):3121-4 [10092760] EMBO J. 1999 Jun 15;18(12):3484-90 [10369687] J Exp Med. 1999 Jul 5;190(1):21-30 [10429667] J Exp Med. 1999 Aug 2;190(3):323-30 [10430621] J Exp Med. 2005 Feb 21;201(4):637-45 [15710654] J Exp Med. 2005 Apr 18;201(8):1191-6 [15824086] J Immunol. 2005 Jun 15;174(12):7781-6 [15944281] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8656-61 [15939880] DNA Repair (Amst). 2006 Mar 7;5(3):392-8 [16443401] J Exp Med. 2006 Feb 20;203(2):319-23 [16476771] Mol Immunol. 2006 Apr;43(10):1587-94 [16263170] Cell. 2006 Jul 28;126(2):297-308 [16873062] J Exp Med. 2007 Jan 22;204(1):17-23 [17190840] Mol Immunol. 2007 Apr;44(11):2800-5 [17336386] J Biol Chem. 2007 Jun 15;282(24):17387-94 [17449470] J Exp Med. 2007 Jul 9;204(7):1677-89 [17591858] Nucleic Acids Res. 2007;35(12):4103-13 [17567611] J Exp Med. 2007 Nov 26;204(12):3017-26 [18025127] Cell. 2000 Sep 1;102(5):553-63 [11007474] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1098/rstb.2008.0188 ER - TY - CPAPER T1 - Exploring Mechanisms Underlying Invasion in HLRCC-Associated Kidney Cancer: Assessing the Contribution of HIF and ROS T2 - 2009 Meeting on Hypoxia and Consequences: from Molecule to Malady AN - 41699555; 4994236 JF - 2009 Meeting on Hypoxia and Consequences: from Molecule to Malady AU - Sourbier, Carole Y1 - 2009/03/12/ PY - 2009 DA - 2009 Mar 12 KW - Cancer KW - Kidneys KW - Reactive oxygen species KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41699555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Meeting+on+Hypoxia+and+Consequences%3A+from+Molecule+to+Malady&rft.atitle=Exploring+Mechanisms+Underlying+Invasion+in+HLRCC-Associated+Kidney+Cancer%3A+Assessing+the+Contribution+of+HIF+and+ROS&rft.au=Sourbier%2C+Carole&rft.aulast=Sourbier&rft.aufirst=Carole&rft.date=2009-03-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Meeting+on+Hypoxia+and+Consequences%3A+from+Molecule+to+Malady&rft.issn=&rft_id=info:doi/ L2 - http://www.nyas.org/pdfs/HypoxiaBrochure_2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Proceedings of the First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES-2007). AN - 733320476; 19278557 AB - The First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES-2007) was held at the North Carolina State University McKimmon Center in Raleigh, North Carolina on October 25th and 26th, 2007. Based on the presentations at the conference and the commitment or interest of the presenters to contribute a manuscript of their research, we compiled this collection of articles as proceedings of the conference and an in-depth topical review of the utility of bioinformatics in the fields of toxicogenomics and environmental genomics. JF - BMC proceedings AU - Bushel, Pierre R AU - Nielsen, Dahlia AU - Tong, Weida AD - Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. bushel@niehs.nih.gov Y1 - 2009/03/10/ PY - 2009 DA - 2009 Mar 10 SP - 1 VL - 3 Suppl 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733320476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+proceedings&rft.atitle=Proceedings+of+the+First+International+Conference+on+Toxicogenomics+Integrated+with+Environmental+Sciences+%28TIES-2007%29.&rft.au=Bushel%2C+Pierre+R%3BNielsen%2C+Dahlia%3BTong%2C+Weida&rft.aulast=Bushel&rft.aufirst=Pierre&rft.date=2009-03-10&rft.volume=3+Suppl+2&rft.issue=&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=BMC+proceedings&rft.issn=1753-6561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-15 N1 - Date created - 2009-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMC Genomics. 2008;9:288 [18558008] J Proteome Res. 2008 Jul;7(7):2973-9 [18529071] Nat Biotechnol. 2006 Sep;24(9):1151-61 [16964229] Nat Biotechnol. 2006 Sep;24(9):1103 [16964221] Environ Health Perspect. 2006 Jan;114(1):A14 [16393638] Toxicology. 2005 Oct 1;213(3):177-93 [15996808] Mutat Res. 2002 Jan 29;499(1):27-52 [11804603] Mutat Res. 2005 Aug 4;575(1-2):4-16 [15885710] Mol Carcinog. 1999 Mar;24(3):153-9 [10204799] Am J Hum Genet. 1995 Mar;56(3):799-810 [7887436] Environ Health Perspect. 2004 Mar;112(4):495-505 [15033600] Int J Hyg Environ Health. 2003 Aug;206(4-5):263-7 [12971681] Nat Genet. 2003 Aug;34(4):429-33 [12881721] Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):84-90 [16002116] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Breast cancer risk in elderly women with systemic autoimmune rheumatic diseases: a population-based case-control study AN - 20749622; 9206343 AB - Systemic autoimmune rheumatic diseases (SARDs) are chronic inflammatory and immuno-modulatory conditions that have been suggested to affect cancer risk. Using the Surveillance, Epidemiology and End Results-Medicare-linked database, women aged 67-99 years and diagnosed with incident breast cancer in 1993-2002 (n = 84 778) were compared with an equal number of age-matched cancer-free female controls. Diagnoses of SARDs, including rheumatoid arthritis (RA n = 5238), systemic lupus erythematosus (SLE, n = 340), Sjogren's syndrome (n = 374), systemic sclerosis (n = 128), and dermatomyositis (n = 31), were determined from claim files for individuals from age 65 years to 1 year before selection. Associations of SARD diagnoses with breast cancer, overall and by oestrogen receptor (ER) expression, were assessed using odds ratio (OR) estimates from multivariable logistic regression models. The women diagnosed with RA were less likely to develop breast cancer (OR = 0.87, 95% confidence interval (Cl) =0.82-0.93). The risk reduction did not differ by tumour ER-status (OR= 0.83, 95% Cl = 0.78-0.89 for ER-positive vs OR= 0.91,95% Cl = 0.81 -1.04 for ER-negative, P for heterogeneity=0.14). The breast cancer risk was not associated with any of the other SARDs, except for a risk reduction of ER-negative cases (OR=0.49, 95% Cl = 0.26-0.93) among women with SLE These findings suggest that systemic inflammation may affect breast epithelial neoplasia. JF - British Journal of Cancer AU - Gadalla, S M AU - Amr, S AU - Langenberg, P AU - Baumgarten, M AU - Davidson, W F AU - Schairer, C AU - Engels, E A AU - Pfeiffer, R M AU - Goedert, J J AD - Division of Cancer Epidemiolog/ and Genetics, National Cancer Institute, Bethesda, MD 20892, USA, goedertj@mail.nih.gov Y1 - 2009/03/10/ PY - 2009 DA - 2009 Mar 10 SP - 817 EP - 821 VL - 100 IS - 5 SN - 0007-0920, 0007-0920 KW - Risk Abstracts; Immunology Abstracts KW - Age KW - Systemic sclerosis KW - Cancer KW - Neoplasia KW - Models KW - Rheumatic diseases KW - Inflammation KW - Sjogren's syndrome KW - risk reduction KW - Databases KW - Dermatomyositis KW - Rheumatoid arthritis KW - Epidemiology KW - rheumatoid arthritis KW - Regression analysis KW - Geriatrics KW - Breast cancer KW - Females KW - Systemic lupus erythematosus KW - elderly KW - Estrogen receptors KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20749622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Breast+cancer+risk+in+elderly+women+with+systemic+autoimmune+rheumatic+diseases%3A+a+population-based+case-control+study&rft.au=Gadalla%2C+S+M%3BAmr%2C+S%3BLangenberg%2C+P%3BBaumgarten%2C+M%3BDavidson%2C+W+F%3BSchairer%2C+C%3BEngels%2C+E+A%3BPfeiffer%2C+R+M%3BGoedert%2C+J+J&rft.aulast=Gadalla&rft.aufirst=S&rft.date=2009-03-10&rft.volume=100&rft.issue=5&rft.spage=817&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604906 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Systemic sclerosis; Neoplasia; Inflammation; Rheumatic diseases; Models; Sjogren's syndrome; Databases; Rheumatoid arthritis; Dermatomyositis; Epidemiology; Geriatrics; Regression analysis; Breast cancer; Systemic lupus erythematosus; Estrogen receptors; risk reduction; Age; rheumatoid arthritis; Females; elderly; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6604906 ER - TY - CPAPER T1 - Quality Metrics of Formalin Fixed Paraffin Embedded Tissue T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41796552; 5041228 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Hewitt, Stephen Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Paraffin KW - Formaldehyde KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41796552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=Quality+Metrics+of+Formalin+Fixed+Paraffin+Embedded+Tissue&rft.au=Hewitt%2C+Stephen&rft.aulast=Hewitt&rft.aufirst=Stephen&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NCI Best Practices for Biospecimen Resources and the Biospecimen Research Network T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41793121; 5041319 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Lim, Mark AU - Moore, Helen AU - Compton, Carolyn Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Best practices KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41793121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=The+NCI+Best+Practices+for+Biospecimen+Resources+and+the+Biospecimen+Research+Network&rft.au=Lim%2C+Mark%3BMoore%2C+Helen%3BCompton%2C+Carolyn&rft.aulast=Lim&rft.aufirst=Mark&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Funding Opportunities and Resources for Biospecimen Research from the National Cancer Institute T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41788694; 5041233 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Lim, Mark Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Cancer KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41788694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=Funding+Opportunities+and+Resources+for+Biospecimen+Research+from+the+National+Cancer+Institute&rft.au=Lim%2C+Mark&rft.aulast=Lim&rft.aufirst=Mark&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Overview of the NIH Genes, Environment, and Health Initiative T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41785797; 5039768 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Balshaw, David Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41785797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=An+Overview+of+the+NIH+Genes%2C+Environment%2C+and+Health+Initiative&rft.au=Balshaw%2C+David&rft.aulast=Balshaw&rft.aufirst=David&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic and Molecular Studies of nrg1/erbb4 T2 - 2009 Keystone Symposia on Epigenetic Basis of Neurodevelopmental Disorders (X2) AN - 41956501; 5115020 JF - 2009 Keystone Symposia on Epigenetic Basis of Neurodevelopmental Disorders (X2) AU - Weinberger, Daniel Y1 - 2009/03/06/ PY - 2009 DA - 2009 Mar 06 KW - ErbB-2 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41956501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Epigenetic+Basis+of+Neurodevelopmental+Disorders+%28X2%29&rft.atitle=Genetic+and+Molecular+Studies+of+nrg1%2Ferbb4&rft.au=Weinberger%2C+Daniel&rft.aulast=Weinberger&rft.aufirst=Daniel&rft.date=2009-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Epigenetic+Basis+of+Neurodevelopmental+Disorders+%28X2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 07 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetics and Brain Development of Childhood Onset Schizophrenia T2 - 2009 Keystone Symposia on the Molecular Basis of Schizophrenia and Bipolar Disorder (X1) AN - 41912198; 5115283 JF - 2009 Keystone Symposia on the Molecular Basis of Schizophrenia and Bipolar Disorder (X1) AU - Rapoport, Judith Y1 - 2009/03/06/ PY - 2009 DA - 2009 Mar 06 KW - Mental disorders KW - Genetics KW - Children KW - Brain KW - Schizophrenia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41912198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+the+Molecular+Basis+of+Schizophrenia+and+Bipolar+Disorder+%28X1%29&rft.atitle=Genetics+and+Brain+Development+of+Childhood+Onset+Schizophrenia&rft.au=Rapoport%2C+Judith&rft.aulast=Rapoport&rft.aufirst=Judith&rft.date=2009-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+the+Molecular+Basis+of+Schizophrenia+and+Bipolar+Disorder+%28X1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetics and Brain Development of Childhood Onset Schizophrenia: Update 2009 T2 - 2009 Keystone Symposia on Epigenetic Basis of Neurodevelopmental Disorders (X2) AN - 41903532; 5115026 JF - 2009 Keystone Symposia on Epigenetic Basis of Neurodevelopmental Disorders (X2) AU - Rapoport, Judith Y1 - 2009/03/06/ PY - 2009 DA - 2009 Mar 06 KW - Mental disorders KW - Genetics KW - Children KW - Brain KW - Schizophrenia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41903532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Epigenetic+Basis+of+Neurodevelopmental+Disorders+%28X2%29&rft.atitle=Genetics+and+Brain+Development+of+Childhood+Onset+Schizophrenia%3A+Update+2009&rft.au=Rapoport%2C+Judith&rft.aulast=Rapoport&rft.aufirst=Judith&rft.date=2009-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Epigenetic+Basis+of+Neurodevelopmental+Disorders+%28X2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 07 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reported Hearing Loss and Associated Factors in the US, 2007 T2 - 2009 Annual Meeting of the American Auditory Society (AAS 2009) AN - 41802764; 5050237 JF - 2009 Annual Meeting of the American Auditory Society (AAS 2009) AU - Hoffman, Howard AU - Losonczy, Katalin AU - Chiu, May AU - Ko, Chia-Wen Y1 - 2009/03/05/ PY - 2009 DA - 2009 Mar 05 KW - Hearing loss KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41802764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+American+Auditory+Society+%28AAS+2009%29&rft.atitle=Reported+Hearing+Loss+and+Associated+Factors+in+the+US%2C+2007&rft.au=Hoffman%2C+Howard%3BLosonczy%2C+Katalin%3BChiu%2C+May%3BKo%2C+Chia-Wen&rft.aulast=Hoffman&rft.aufirst=Howard&rft.date=2009-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+American+Auditory+Society+%28AAS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.amauditorysoc.org/downloads/2009_AAS_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Carcinogenesis studies of cresols in rats and mice. AN - 66877358; 19114085 AB - Cresols, monomethyl derivatives of phenol, are high production chemicals with potential for human exposure. The three isomeric forms of cresol are used individually or in mixtures as disinfectants, preservatives, and solvents or as intermediates in the production of antioxidants, fragrances, herbicides, insecticides, dyes, and explosives. Carcinogenesis studies were conducted in groups of 50 male F344/N rats and 50 female B6C3F1 mice exposed to a 60:40 mixture of m- and p-cresols (m-/p-cresol) in feed. Rats and mice were fed diets containing 0, 1500, 5000, or 15,000 ppm and 0, 1000, 3000, or 10,000 ppm, respectively. Survival of each exposed group was similar to that of their respective control group. Mean body weight gains were depressed in rats exposed to 15,000 ppm and in mice exposed to 3000 ppm and higher. A decrease of 25% over that of controls for the final mean body weight in mice exposed to 10,000 ppm appeared to be associated with lack of palatability of the feed. A marginally increased incidence of renal tubule adenoma was observed in the 15,000-ppm-exposed rats. The increased incidence was not statistically significant, but did exceed the range of historical controls. No increased incidence of hyperplasia of the renal tubules was observed; however, a significantly increased incidence of hyperplasia of the transitional epithelium associated with an increased incidence of nephropathy was observed at the high exposure concentration. The only significantly increased incidence of a neoplastic lesion related to cresol exposure observed in these studies was that of squamous cell papilloma in the forestomach of 10,000-ppm-exposed mice. A definitive association with irritation at the site-of-contact could not be made because of limited evidence of injury to the gastric mucosa at the time of necropsy. However, given the minimal chemical-related neoplastic response in these studies, it was concluded that there was no clear evidence of carcinogenicity in male rats or female mice exposed to the cresol mixture. JF - Toxicology AU - Sanders, J M AU - Bucher, J R AU - Peckham, J C AU - Kissling, G E AU - Hejtmancik, M R AU - Chhabra, R S AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States. sander10@niehs.nih.gov Y1 - 2009/03/04/ PY - 2009 DA - 2009 Mar 04 SP - 33 EP - 39 VL - 257 IS - 1-2 SN - 0300-483X, 0300-483X KW - Carcinogens KW - 0 KW - Cresols KW - Index Medicus KW - Eating -- drug effects KW - Stomach Neoplasms -- pathology KW - Animals KW - Kidney Tubules -- pathology KW - Papilloma -- pathology KW - Dose-Response Relationship, Drug KW - Mice KW - Gastric Mucosa -- pathology KW - Rats KW - Rats, Inbred F344 KW - Stomach Neoplasms -- chemically induced KW - Kidney Tubules -- drug effects KW - Adenoma -- chemically induced KW - Body Weight -- drug effects KW - Gastric Mucosa -- drug effects KW - Adenoma -- pathology KW - Time Factors KW - Papilloma -- chemically induced KW - Female KW - Male KW - Kidney Neoplasms -- pathology KW - Neoplasms -- pathology KW - Cresols -- toxicity KW - Kidney Neoplasms -- chemically induced KW - Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Carcinogenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66877358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Carcinogenesis+studies+of+cresols+in+rats+and+mice.&rft.au=Sanders%2C+J+M%3BBucher%2C+J+R%3BPeckham%2C+J+C%3BKissling%2C+G+E%3BHejtmancik%2C+M+R%3BChhabra%2C+R+S&rft.aulast=Sanders&rft.aufirst=J&rft.date=2009-03-04&rft.volume=257&rft.issue=1-2&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2008.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-20 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 1990 Apr;85:177-86 [2200661] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Forensic Sci Int. 1990 Aug;47(1):21-9 [2210550] Annu Rev Pharmacol Toxicol. 1991;31:621-52 [2064387] Food Chem Toxicol. 1992 Apr;30(4):333-40 [1628870] Environ Health Perspect. 1993 Oct;101 Suppl 3:341-4 [8143642] Chem Res Toxicol. 1995 Jan-Feb;8(1):55-60 [7703367] Pharmacology. 1995 Sep;51(3):195-204 [7501706] J Chromatogr B Biomed Sci Appl. 1997 Dec 5;703(1-2):105-13 [9448067] Vet Hum Toxicol. 1998 Dec;40(6):341-3 [9830694] Bull Environ Contam Toxicol. 1999 Sep;63(3):399-406 [10475920] J Dairy Sci. 2005 Jan;88(1):7-12 [15591361] J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Mar 25;817(2):309-17 [15687000] Drug Metab Dispos. 2005 Dec;33(12):1867-76 [16174805] Environ Sci Pollut Res Int. 2006 Mar;13(2):83-9 [16612896] Chem Res Toxicol. 2001 Jan;14(1):25-33 [11170505] J Agric Food Chem. 2001 Mar;49(3):1382-7 [11312868] J Contam Hydrol. 2001 Dec 15;53(3-4):233-67 [11820472] Toxicol Lett. 2002 Mar 24;129(1-2):65-76 [11879975] J Agric Food Chem. 2002 Mar 27;50(7):2016-21 [11902950] Forensic Sci Int. 2002 Mar 28;126(1):77-81 [11955837] Toxicol Pathol. 2002 Nov-Dec;30(6):681-6 [12512869] Anal Bioanal Chem. 2003 Jun;376(3):413-21 [12732922] Nephrol Dial Transplant. 2003 Jul;18(7):1299-306 [12808165] Biodegradation. 2003 Aug;14(4):297-307 [12948059] Leg Med (Tokyo). 2004 Mar;6(1):32-40 [15177071] Med Sci Law. 1975 Jan;15(1):65-6 [1219312] Am J Clin Nutr. 1976 Dec;29(12):1448-54 [826152] Toxicol Appl Pharmacol. 1977 Nov;42(2):417-23 [595018] Br J Ind Med. 1981 May;38(2):194-7 [7236546] J Natl Cancer Inst. 1983 Feb;70(2):343-52 [6571941] J Hyg Epidemiol Microbiol Immunol. 1984;28(2):129-38 [6470477] Biometrics. 1988 Jun;44(2):417-31 [3390507] Environ Health Perspect. 1990 Apr;85:187-208 [2200662] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2008.12.005 ER - TY - JOUR T1 - Dynamic regulation of mitochondrial function by glucocorticoids. AN - 66990911; 19202080 AB - Glucocorticoids play an important biphasic role in modulating neural plasticity; low doses enhance neural plasticity and spatial memory behavior, whereas chronic, higher doses produce inhibition. We found that 3 independent measures of mitochondrial function-mitochondrial oxidation, membrane potential, and mitochondrial calcium holding capacity-were regulated by long-term corticosterone (CORT) treatment in an inverted "U"-shape. This regulation of mitochondrial function by CORT correlated with neuroprotection; that is, treatment with low doses of CORT had a neuroprotective effect, whereas treatment with high doses of CORT enhanced kainic acid (KA)-induced toxicity of cortical neurons. We then undertook experiments to elucidate the mechanisms underlying these biphasic effects and found that glucocorticoid receptors (GRs) formed a complex with the anti-apoptotic protein Bcl-2 in response to CORT treatment and translocated with Bcl-2 into mitochondria after acute treatment with low or high doses of CORT in primary cortical neurons. However, after 3 days of treatment, high, but not low, doses of CORT resulted in decreased GR and Bcl-2 levels in mitochondria. As with the in vitro studies, Bcl-2 levels in the mitochondria of the prefrontal cortex were significantly decreased, along with GR levels, after long-term treatment with high-dose CORT in vivo. These findings have the potential to contribute to a more complete understanding of the mechanisms by which glucocorticoids and chronic stress regulate cellular plasticity and resilience and to inform the future development of improved therapeutics. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Du, Jing AU - Wang, Yun AU - Hunter, Richard AU - Wei, Yanling AU - Blumenthal, Rayah AU - Falke, Cynthia AU - Khairova, Rushaniya AU - Zhou, Rulun AU - Yuan, Peixiong AU - Machado-Vieira, Rodrigo AU - McEwen, Bruce S AU - Manji, Husseini K AD - Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/03/03/ PY - 2009 DA - 2009 Mar 03 SP - 3543 EP - 3548 VL - 106 IS - 9 KW - Glucocorticoids KW - 0 KW - Proto-Oncogene Proteins c-bcl-2 KW - Mifepristone KW - 320T6RNW1F KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Animals KW - Neurons -- metabolism KW - Prefrontal Cortex -- metabolism KW - Tissue Culture Techniques KW - Biological Transport KW - Membrane Potential, Mitochondrial KW - Mifepristone -- pharmacology KW - Cell Survival KW - Oxidation-Reduction KW - Corticosterone -- metabolism KW - Neurons -- cytology KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Time Factors KW - Glucocorticoids -- metabolism KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66990911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Dynamic+regulation+of+mitochondrial+function+by+glucocorticoids.&rft.au=Du%2C+Jing%3BWang%2C+Yun%3BHunter%2C+Richard%3BWei%2C+Yanling%3BBlumenthal%2C+Rayah%3BFalke%2C+Cynthia%3BKhairova%2C+Rushaniya%3BZhou%2C+Rulun%3BYuan%2C+Peixiong%3BMachado-Vieira%2C+Rodrigo%3BMcEwen%2C+Bruce+S%3BManji%2C+Husseini+K&rft.aulast=Du&rft.aufirst=Jing&rft.date=2009-03-03&rft.volume=106&rft.issue=9&rft.spage=3543&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0812671106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-01 N1 - Date created - 2009-03-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1985 Sep 27;229(4720):1397-400 [4035356] EMBO J. 1984 Apr;3(4):751-5 [6327286] Exp Clin Endocrinol. 1988 Mar;92(3):275-9 [2855318] Neuroscience. 1990;37(2):367-75 [2133348] J Neurochem. 1992 May;58(5):1730-5 [1560229] Neuroendocrinology. 1992 Mar;55(3):344-50 [1323803] J Steroid Biochem Mol Biol. 1995 Nov;55(2):135-46 [7495692] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9893-8 [8790427] Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14048-53 [9391150] Brain Res Brain Res Protoc. 1998 Mar;2(3):209-14 [9507134] Oncogene. 1998 Feb 26;16(8):1055-63 [9519879] Ann N Y Acad Sci. 1998 May 1;840:33-44 [9629234] Life Sci. 1998;63(5):357-68 [9714423] Mol Psychiatry. 2005 Aug;10(8):790-8 [15940303] Trends Pharmacol Sci. 2006 May;27(5):244-50 [16584791] Biochem Biophys Res Commun. 2007 Mar 2;354(1):253-8 [17222799] J Neurosci. 2008 Jan 2;28(1):68-79 [18171924] Biochim Biophys Acta. 2007 Dec;1773(12):1701-20 [18240421] Eur J Pharmacol. 2008 Apr 7;583(2-3):174-85 [18282566] Front Neuroendocrinol. 2008 May;29(2):273-91 [18054070] Biol Psychiatry. 2000 Oct 15;48(8):755-65 [11063972] Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1653-9 [11381074] Nat Neurosci. 2001 Dec;4(12):1169-71 [11713467] J Cell Biol. 2003 Oct 27;163(2):385-95 [14581459] Mol Cell Endocrinol. 2003 Nov 14;209(1-2):51-60 [14604816] News Physiol Sci. 2003 Dec;18:252-6 [14614159] Neuroscience. 2004;126(2):503-9 [15207367] J Cell Mol Med. 2004 Apr-Jun;8(2):181-90 [15256066] Psychosom Med. 1981 Apr;43(2):127-32 [7267936] Nature. 1987 Aug 13-19;328(6131):624-6 [3614365] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0812671106 ER - TY - JOUR T1 - Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy. AN - 66989629; 19218456 AB - Forward genetic screens with ENU (N-ethyl-N-nitrosourea) mutagenesis can facilitate gene discovery, but mutation identification is often difficult. We present the first study in which an ENU-induced mutation was identified by massively parallel DNA sequencing. This mutation causes heterotaxy and complex congenital heart defects and was mapped to a 2.2-Mb interval on mouse chromosome 7. Massively parallel sequencing of the entire 2.2-Mb interval identified 2 single-base substitutions, one in an intergenic region and a second causing replacement of a highly conserved cysteine with arginine (C193R) in the gene Megf8. Megf8 is evolutionarily conserved from human to fruit fly, and is observed to be ubiquitously expressed. Morpholino knockdown of Megf8 in zebrafish embryos resulted in a high incidence of heterotaxy, indicating a conserved role in laterality specification. Megf8(C193R) mouse mutants show normal breaking of symmetry at the node, but Nodal signaling failed to be propagated to the left lateral plate mesoderm. Videomicroscopy showed nodal cilia motility, which is required for left-right patterning, is unaffected. Although this protein is predicted to have receptor function based on its amino acid sequence, surprisingly confocal imaging showed it is translocated into the nucleus, where it is colocalized with Gfi1b and Baf60C, two proteins involved in chromatin remodeling. Overall, through the recovery of an ENU-induced mutation, we uncovered Megf8 as an essential regulator of left-right patterning. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Zhang, Zhen AU - Alpert, Deanne AU - Francis, Richard AU - Chatterjee, Bishwanath AU - Yu, Qing AU - Tansey, Terry AU - Sabol, Steven L AU - Cui, Cheng AU - Bai, Yongli AU - Koriabine, Maxim AU - Yoshinaga, Yuko AU - Cheng, Jan-Fang AU - Chen, Feng AU - Martin, Joel AU - Schackwitz, Wendy AU - Gunn, Teresa M AU - Kramer, Kenneth L AU - De Jong, Pieter J AU - Pennacchio, Len A AU - Lo, Cecilia W AD - Laboratory of Developmental Biology, National Heart Lung and Blood Institute, Bethesda, MD 20892-1583, USA. Y1 - 2009/03/03/ PY - 2009 DA - 2009 Mar 03 SP - 3219 EP - 3224 VL - 106 IS - 9 KW - Megf8 protein, zebrafish KW - 0 KW - Membrane Proteins KW - Nodal Protein KW - Zebrafish Proteins KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Active Transport, Cell Nucleus KW - Animals KW - Zebrafish -- metabolism KW - Humans KW - Embryo, Nonmammalian -- embryology KW - Amino Acid Sequence KW - Base Sequence KW - Sequence Alignment KW - Cells, Cultured KW - Molecular Sequence Data KW - Mutation -- genetics KW - Embryo, Nonmammalian -- metabolism KW - Zebrafish -- genetics KW - Zebrafish -- embryology KW - Embryo, Nonmammalian -- drug effects KW - Signal Transduction KW - Gene Expression Regulation, Developmental -- drug effects KW - Nodal Protein -- metabolism KW - Body Patterning KW - Zebrafish Proteins -- chemistry KW - Membrane Proteins -- chemistry KW - Membrane Proteins -- metabolism KW - Zebrafish Proteins -- genetics KW - Membrane Proteins -- genetics KW - Zebrafish Proteins -- metabolism KW - Ethylnitrosourea -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66989629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Massively+parallel+sequencing+identifies+the+gene+Megf8+with+ENU-induced+mutation+causing+heterotaxy.&rft.au=Zhang%2C+Zhen%3BAlpert%2C+Deanne%3BFrancis%2C+Richard%3BChatterjee%2C+Bishwanath%3BYu%2C+Qing%3BTansey%2C+Terry%3BSabol%2C+Steven+L%3BCui%2C+Cheng%3BBai%2C+Yongli%3BKoriabine%2C+Maxim%3BYoshinaga%2C+Yuko%3BCheng%2C+Jan-Fang%3BChen%2C+Feng%3BMartin%2C+Joel%3BSchackwitz%2C+Wendy%3BGunn%2C+Teresa+M%3BKramer%2C+Kenneth+L%3BDe+Jong%2C+Pieter+J%3BPennacchio%2C+Len+A%3BLo%2C+Cecilia+W&rft.aulast=Zhang&rft.aufirst=Zhen&rft.date=2009-03-03&rft.volume=106&rft.issue=9&rft.spage=3219&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0813400106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-01 N1 - Date created - 2009-03-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Biol. 1999 Nov 18;9(22):1339-42 [10574770] Science. 2009 Jan 2;323(5910):133-8 [19023044] Genes Dev. 2002 Feb 1;16(3):301-6 [11825872] Curr Biol. 2002 Jun 4;12(11):938-43 [12062060] Genes Dev. 2002 Sep 15;16(18):2339-44 [12231623] Dev Biol. 2003 Apr 1;256(1):160-72 [12654299] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3960-4 [12651960] Methods Mol Biol. 2004;255:1-46 [15020813] Mamm Genome. 2004 Aug;15(8):585-91 [15457338] Nature. 1980 Oct 30;287(5785):795-801 [6776413] Proc Natl Acad Sci U S A. 1998 May 26;95(11):5857-64 [9600884] Cell. 1998 Dec 11;95(6):829-37 [9865700] Development. 2004 Dec;131(24):6211-23 [15548583] Science. 2005 Sep 9;309(5741):1728-32 [16081699] Nature. 2005 Sep 15;437(7057):376-80 [16056220] Physiol Genomics. 2005 Dec 14;24(1):23-36 [16174781] Cell. 2006 Apr 7;125(1):33-45 [16615888] Development. 2006 Jun;133(11):2095-104 [16672339] Cell. 2006 May 19;125(4):801-14 [16713569] EMBO J. 2006 Jun 7;25(11):2409-19 [16688220] Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11240-5 [16840556] Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):846-51 [17210915] Proc Natl Acad Sci U S A. 2007 May 29;104(22):9387-92 [17517648] Development. 2007 Nov;134(21):3893-904 [17913787] Nat Methods. 2007 Nov;4(11):903-5 [17934467] Nat Genet. 2007 Dec;39(12):1522-7 [17982454] Genes Dev. 2007 Dec 15;21(24):3272-82 [18079174] Pediatr Res. 2008 Jan;63(1):9-14 [18043505] Genome Res. 2008 Jan;18(1):172-7 [18032722] Nat Genet. 2008 Jul;40(7):897-903 [18552846] Neuron. 2000 Nov;28(2):399-409 [11144351] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0813400106 ER - TY - JOUR T1 - Origin, antiviral function and evidence for positive selection of the gammaretrovirus restriction gene Fv1 in the genus Mus AN - 20212591; 10314755 AB - The Fv1 virus resistance gene is a coopted endogenous retrovirus (ERV) sequence related to the gag gene of the MuERV-L ERV family. Three major Fv1 resistance alleles have been identified in laboratory mice, and they target virus capsid genes to produce characteristic patterns of resistance to mouse leukemia viruses (MLVs). We identified Fv1 in 3 of the 4 Mus subgenera; its absence from Coelomys and 1 of 3 species of Pyromys indicate Fv1 was acquired shortly after the origin of the Mus genus. We sequenced Fv1 genes from 21 mice representative of the major taxonomic groups of Mus. Two lines of evidence indicate that Fv1 has had antiviral function for 7 million years of evolution. First, 2 species of African pygmy mice (subgenus Nannomys) show an Fv1-like MLV resistance, and transduced cells expressing the Nannomys Fv1 gene reproduce this resistance pattern. Second, sequence comparisons suggest that Fv1 has been involved in genetic conflicts throughout Mus evolution. We found evidence for strong positive selection of Fv1 and identified 6 codons that show evidence of positive selection: 3 codons in the C-terminal region including 2 previously shown to contribute to Fv1 restriction in laboratory mice, and 3 codons in a 10-codon segment overlapping the major homology region of Fv1; this segment is known to be involved in capsid multimerization. This analysis suggests that Fv1 has had an antiviral role throughout Mus evolution predating exposure of mice to the MLVs restricted by laboratory mouse Fv1, and suggests a mechanism for Fv1 restriction. JF - Proceedings of the National Academy of Sciences, USA AU - Yan, Yuhe AU - Buckler-White, Alicia AU - Wollenberg, Kurt AU - Kozak, Christine A Y1 - 2009/03/03/ PY - 2009 DA - 2009 Mar 03 SP - 3259 EP - 3263 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 9 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Virology & AIDS Abstracts KW - Antiviral activity KW - Capsids KW - Codons KW - Disease resistance KW - Evolution KW - Fv1 gene KW - Gag protein KW - Homology KW - Leukemia KW - Positive selection KW - Retrovirus KW - Mus KW - A 01340:Antibiotics & Antimicrobials KW - G 07740:Evolution KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20212591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Origin%2C+antiviral+function+and+evidence+for+positive+selection+of+the+gammaretrovirus+restriction+gene+Fv1+in+the+genus+Mus&rft.au=Yan%2C+Yuhe%3BBuckler-White%2C+Alicia%3BWollenberg%2C+Kurt%3BKozak%2C+Christine+A&rft.aulast=Yan&rft.aufirst=Yuhe&rft.date=2009-03-03&rft.volume=106&rft.issue=9&rft.spage=3259&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0900181106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Capsids; Leukemia; Retrovirus; Homology; Fv1 gene; Codons; Disease resistance; Antiviral activity; Positive selection; Gag protein; Evolution; Mus DO - http://dx.doi.org/10.1073/pnas.0900181106 ER - TY - JOUR T1 - Current status of nanotechnology approaches for cardiovascular disease: a personal perspective AN - 869595316; 14821098 AB - Nanotechnology is poised to have an increasing impact on cardiovascular health in coming years. Diagnostically, multiplexed point-of-care devices will enable rapid genotyping and biomarker measurement to optimize and tailor therapies for the individual patient. Nanoparticle-based molecular imaging agents will take advantage of targeted agents to provide increased insight into disease pathways rather then simply providing structural and functional information. Drug delivery will be impacted by targeting of nanoparticle-encapsulated drugs to the site of action, increasing the effective concentration and decreasing systemic dosage and side effects. Controlled and tailored release of drugs from polymers will improve control of pharmacokinetics and bioavailability. The application of nanotechnology to tissue engineering will facilitate the fabrication of better tissue implants in vitro, and provide scaffolds to promote regeneration in vivo taking advantage of the body's own repair mechanisms. Medical devices will benefit from the development of nanostructured surfaces and coatings to provide better control of thrombogenicity and infection. Taken together, these new technologies have enormous potential for improving the diagnosis and treatment of cardiovascular diseases. JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Buxton, Denis B AD - National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Bethesda, MD 20892-7940, USA., db225a@nih.gov Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 SP - 149 EP - 155 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 1 IS - 2 SN - 1939-0041, 1939-0041 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Genotyping KW - Infection KW - Tissue engineering KW - biomarkers KW - scaffolds KW - Pharmacokinetics KW - Bioavailability KW - Structure-function relationships KW - Computed tomography KW - Cardiovascular diseases KW - Side effects KW - Coatings KW - nanotechnology KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869595316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Current+status+of+nanotechnology+approaches+for+cardiovascular+disease%3A+a+personal+perspective&rft.au=Buxton%2C+Denis+B&rft.aulast=Buxton&rft.aufirst=Denis&rft.date=2009-03-01&rft.volume=1&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Drug delivery; Genotyping; Tissue engineering; Infection; biomarkers; Pharmacokinetics; scaffolds; Bioavailability; Structure-function relationships; Computed tomography; Cardiovascular diseases; Side effects; nanotechnology; Coatings DO - http://dx.doi.org/10.1002/wnan.8 ER - TY - JOUR T1 - MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine AN - 754893269; 13521833 AB - Referred to as the micromanagers of gene expression, microRNAs (miRNAs) are evolutionarily conserved small noncoding RNAs. Polymorphisms in the miRNA pathway (miR-polymorphisms) are emerging as powerful tools to study the biology of a disease and have the potential to be used in disease prognosis and diagnosis. Detection of miR-polymorphisms holds promise in the field of miRNA pharmacogenomics, molecular epidemiology and for individualized medicine. MiRNA pharmacogenomics can be defined as the study of miRNAs and polymorphisms affecting miRNA function in order to predict drug behavior and to improve drug efficacy. Advancements in the miRNA field indicate the clear involvement of miRNAs and genetic variations within the miRNA pathway in the progression and prognosis of diseases such as cancer, neurological disorders, muscular hypertrophy, gastric mucosal atrophy, cardiovascular disease and Type II diabetes. Various algorithms are available to predict miRNA-target mRNA sites; however, it is advisable to use multiple algorithms to confirm the predictions. Polymorphisms that may potentially affect miRNA-mediated regulation of the cell can be present not only in the 3-UTR of a miRNA target gene, but also in the genes involved in miRNA biogenesis and in pri-, pre- and mature-miRNA sequences. A polymorphism in processed miRNAs may affect expression of several genes and have serious consequences, whereas a polymorphism in miRNA target site, in the 3-UTR of the target mRNA, may be more target and/or pathway specific. In this review, we for the first time suggest a classification of miRNA polymorphisms/mutations. We also describe the importance and implications of miR-polymorphisms in gene regulation, disease progression, pharmacogenomics and molecular epidemiology. JF - Pharmacogenomics AU - Mishra, Prasun J AU - Bertino, Joseph R AD - super(1)Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20892-4264, USA. Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 399 EP - 416 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB UK VL - 10 IS - 3 SN - 1462-2416, 1462-2416 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Neurological diseases KW - pharmacogenomics KW - Gene polymorphism KW - Mucosa KW - miRNA KW - Prognosis KW - Algorithms KW - Cancer KW - Diabetes mellitus KW - Hypertrophy KW - Epidemiology KW - Gene regulation KW - Atrophy KW - Cardiovascular diseases KW - Mutation KW - Evolution KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754893269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics&rft.atitle=MicroRNA+polymorphisms%3A+the+future+of+pharmacogenomics%2C+molecular+epidemiology+and+individualized+medicine&rft.au=Mishra%2C+Prasun+J%3BBertino%2C+Joseph+R&rft.aulast=Mishra&rft.aufirst=Prasun&rft.date=2009-03-01&rft.volume=10&rft.issue=3&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics&rft.issn=14622416&rft_id=info:doi/10.2217%2F14622416.10.3.399 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Neurological diseases; pharmacogenomics; Gene polymorphism; miRNA; Mucosa; Algorithms; Prognosis; Cancer; Diabetes mellitus; Hypertrophy; Epidemiology; Gene regulation; Atrophy; Cardiovascular diseases; Mutation; Evolution DO - http://dx.doi.org/10.2217/14622416.10.3.399 ER - TY - JOUR T1 - How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum AN - 746225942; 12879023 AB - Human leukocytes, including macrophages and neutrophils, are phagocytic immune cells that capture and engulf pathogens and subsequently destroy them in intracellular vesicles. To accomplish this vital task, these leukocytes utilize two basic cell behaviors--chemotaxis for chasing down infectious pathogens and phagocytosis for destroying them. The molecular mechanisms controlling these behaviors are not well understood for immune cells. Interestingly, a soil amoeba, Dictyostelium discoideum, uses these same behaviors to pursue and injest its bacterial food source and to organize its multi-cellular development. Consequently, studies of this model system have provided and will continue to provide us with mechanistic insights into the chemotaxis and phagocytosis of immune cells. Here, we review recent research in these areas that have been conducted in the Chemotaxis Signal Section of NIAID's Laboratory of Immunogenetics. JF - Immunologic Research AU - Jin, Tian AU - Xu, Xuehua AU - Fang, Jun AU - Isik, Nilgun AU - Yan, Jianshe AU - Brzostowski, Joseph A AU - Hereld, Dale AD - Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, 12331 Parklawn Drive, Rockville, MD 20852, USA, tjin@niaid.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 118 EP - 127 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 43 IS - 1-3 SN - 0257-277X, 0257-277X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Dictyostelium discoideum KW - Macrophages KW - Molecular modelling KW - Leukocytes (neutrophilic) KW - Amoeba KW - Development KW - Pathogens KW - Chemotaxis KW - Soil KW - Immunogenetics KW - Phagocytes KW - Reviews KW - Food sources KW - Vesicles KW - Phagocytosis KW - K 03350:Immunology KW - J 02350:Immunology KW - A 01400:Soil Microbes KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746225942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=How+human+leukocytes+track+down+and+destroy+pathogens%3A+lessons+learned+from+the+model+organism+Dictyostelium+discoideum&rft.au=Jin%2C+Tian%3BXu%2C+Xuehua%3BFang%2C+Jun%3BIsik%2C+Nilgun%3BYan%2C+Jianshe%3BBrzostowski%2C+Joseph+A%3BHereld%2C+Dale&rft.aulast=Jin&rft.aufirst=Tian&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8056-7 L2 - http://www.springerlink.com/content/7075460640k10827/?p=80cfe64c784a497d83a909e0c1168af3&pi=9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Macrophages; Molecular modelling; Leukocytes (neutrophilic); Pathogens; Development; Chemotaxis; Soil; Immunogenetics; Phagocytes; Food sources; Reviews; Vesicles; Phagocytosis; Dictyostelium discoideum; Amoeba DO - http://dx.doi.org/10.1007/s12026-008-8056-7 ER - TY - JOUR T1 - Redox warfare between airway epithelial cells and Pseudomonas: dual oxidase versus pyocyanin AN - 746225834; 12879031 AB - The importance of reactive oxygen species-dependent microbial killing by the phagocytic cell NADPH oxidase has been appreciated for some time, although only recently has an appreciation developed for the partnership of lactoperoxidase with related dual oxidases (Duox) within secretions of the airway surface layer. This system produces mild oxidants designed for extracellular killing that are effective against several airway pathogens, including Staphylococcus aureus, Burkholderia cepacia, and Pseudomonas aeruginosa. Establishment of chronic pseudomonas infections involves adaptations to resist oxidant-dependent killing by expression of a redox-active virulence factor, pyocyanin, that competitively inhibits epithelial Duox activity by consuming intracellular NADPH and producing superoxide, thereby inflicting oxidative stress on the host. JF - Immunologic Research AU - Rada, Balazs AU - Leto, Thomas L AD - Laboratory of Host Defenses, National Institutes of Health, National Institute of Allergy and Infectious Diseases, 12441 Parklawn Drive, 20852 Rockville, MD, USA, tleto@nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 198 EP - 209 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 43 IS - 1-3 SN - 0257-277X, 0257-277X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Epithelial cells KW - Adaptations KW - virulence factors KW - Secretions KW - Burkholderia cepacia KW - Pathogens KW - NADP KW - pyocyanin KW - Oxygen KW - Oxidative stress KW - Phagocytes KW - Superoxide KW - Chronic infection KW - NAD(P)H oxidase KW - Pseudomonas aeruginosa KW - Staphylococcus aureus KW - Oxidants KW - Respiratory tract KW - A 01490:Miscellaneous KW - J 02330:Biochemistry KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746225834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Redox+warfare+between+airway+epithelial+cells+and+Pseudomonas%3A+dual+oxidase+versus+pyocyanin&rft.au=Rada%2C+Balazs%3BLeto%2C+Thomas+L&rft.aulast=Rada&rft.aufirst=Balazs&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8071-8 L2 - http://www.springerlink.com/content/607m328w737jm015/?p=78a477da0c704f14852ca7777bec0bc3&pi=17 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Adaptations; virulence factors; Secretions; Pathogens; pyocyanin; NADP; Oxygen; Phagocytes; Oxidative stress; Superoxide; Chronic infection; NAD(P)H oxidase; Oxidants; Respiratory tract; Burkholderia cepacia; Staphylococcus aureus; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1007/s12026-008-8071-8 ER - TY - JOUR T1 - Adaptive immunity to the obligate intracellular pathogen Coxiella burnetii AN - 746225831; 12879025 AB - Coxiella burnetii is an obligate intracellular bacterial pathogen that causes the zoonosis Q fever. While an effective whole-cell vaccine (WCV) against Q fever exists, the vaccine has limitations in being highly reactogenic in sensitized individuals. Thus, a safe and effective vaccine based on recombinant protein antigen (Ag) is desirable. To achieve this goal, a better understanding of the host response to primary infection and the precise mechanisms involved in protective immunity to C. burnetii are needed. This review summarizes our current understanding of adaptive immunity to C. burnetii with a focus on recent developments in the field. JF - Immunologic Research AU - Shannon, Jeffrey G AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, USA, rheinzen@niaid.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 138 EP - 148 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 43 IS - 1-3 SN - 0257-277X, 0257-277X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Coxiella burnetii KW - Vaccines KW - Immunity KW - Pathogens KW - Infection KW - Q fever KW - F 06905:Vaccines KW - A 01490:Miscellaneous KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746225831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Adaptive+immunity+to+the+obligate+intracellular+pathogen+Coxiella+burnetii&rft.au=Shannon%2C+Jeffrey+G%3BHeinzen%2C+Robert+A&rft.aulast=Shannon&rft.aufirst=Jeffrey&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8059-4 L2 - http://www.springerlink.com/content/9j03106g3261r1k4/?p=78a477da0c704f14852ca7777bec0bc3&pi=11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Pathogens; Immunity; Vaccines; Infection; Q fever; Coxiella burnetii DO - http://dx.doi.org/10.1007/s12026-008-8059-4 ER - TY - JOUR T1 - Advances in treatment for chronic granulomatous disease AN - 746224956; 12879019 AB - Chronic granulomatous disease (CGD) is a rare congenital disorder resulting from a failure of neutrophils to produce oxidases. Patients are therefore prone to recurrent infections from various organisms including fungi and atypical bacteria. The mortality in patients with the X-linked form of CGD, the most common type, ranges from 3% to 5% per year and although management of infections has improved with advances in antimicrobial therapies, better methods are needed to be able to cure these patients. Peripheral blood stem cell or bone marrow transplantation, while curative, is not widely used due to the episodic nature of the infections and the belief by many that conservative management is preferable to the risks of transplantation. Still, as will be discussed, improvements in the field are making allogenic transplantation more desirable and tilting the risk benefit ratio in favor of this modality. Additionally, gene therapy, which has been a long touted method to cure CGD, has within the last 5--10 years become more and more of a reality and may be realized by the end of this decade. JF - Immunologic Research AU - Kang, Elizabeth M AU - Malech, Harry L AD - National Institutes of Health, Building 10-Room 6-3752, 10 Center Drive, Bethesda, Maryland 20892, USA, Ekang@niaid.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 77 EP - 84 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 43 IS - 1-3 SN - 0257-277X, 0257-277X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Mortality KW - Stem cells KW - Gene therapy KW - Fungi KW - X chromosome KW - Leukocytes (neutrophilic) KW - Recurrent infection KW - Peripheral blood KW - Chronic granulomatous disease KW - Bone marrow transplantation KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746224956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Advances+in+treatment+for+chronic+granulomatous+disease&rft.au=Kang%2C+Elizabeth+M%3BMalech%2C+Harry+L&rft.aulast=Kang&rft.aufirst=Elizabeth&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8051-z L2 - http://www.springerlink.com/content/8484014p85306046/?p=80cfe64c784a497d83a909e0c1168af3&pi=5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Mortality; Stem cells; Gene therapy; Fungi; X chromosome; Leukocytes (neutrophilic); Peripheral blood; Recurrent infection; Chronic granulomatous disease; Bone marrow transplantation; Antimicrobial agents DO - http://dx.doi.org/10.1007/s12026-008-8051-z ER - TY - JOUR T1 - Neutrophil apoptosis and the resolution of infection AN - 746223612; 12879017 AB - Polymorphonuclear leukocytes (PMNs) are the most abundant white cell in humans and an essential component of the innate immune system. PMNs are typically the first type of leukocyte recruited to sites of infection or areas of inflammation. Ingestion of microorganisms triggers production of reactive oxygen species and fusion of cytoplasmic granules with forming phagosomes, leading to effective killing of ingested microbes. Phagocytosis of bacteria typically accelerates neutrophil apoptosis, which ultimately promotes the resolution of infection. However, some bacterial pathogens alter PMN apoptosis to survive and thereby cause disease. Herein, we review PMN apoptosis and the ability of microorganisms to alter this important process. JF - Immunologic Research AU - Kennedy, Adam D AU - Deleo, Frank R AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA, fdeleo@niaid.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 25 EP - 61 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 43 IS - 1-3 SN - 0257-277X, 0257-277X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Granules KW - Apoptosis KW - Immune system KW - Leukocytes (polymorphonuclear) KW - Phagosomes KW - Leukocytes KW - Leukocytes (neutrophilic) KW - Pathogens KW - Infection KW - Inflammation KW - Reactive oxygen species KW - Reviews KW - Microorganisms KW - Phagocytosis KW - A 01490:Miscellaneous KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746223612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Neutrophil+apoptosis+and+the+resolution+of+infection&rft.au=Kennedy%2C+Adam+D%3BDeleo%2C+Frank+R&rft.aulast=Kennedy&rft.aufirst=Adam&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8049-6 L2 - http://www.springerlink.com/content/m756254lr4326178/?p=80cfe64c784a497d83a909e0c1168af3&pi=3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Granules; Apoptosis; Leukocytes (polymorphonuclear); Immune system; Leukocytes; Phagosomes; Leukocytes (neutrophilic); Pathogens; Infection; Inflammation; Reactive oxygen species; Reviews; Microorganisms; Phagocytosis DO - http://dx.doi.org/10.1007/s12026-008-8049-6 ER - TY - JOUR T1 - Activation and regulation of Toll-Like Receptors (TLRs) by helminth parasites AN - 744719202; 12879035 AB - Helminth (worm) infections are major public health problems that have important socioeconomic consequences for the more than 2 billion infected individuals. Chronicity (their hallmark) can lead to anemia (in hookworm infection), river blindness (onchcerciasis), cirrhosis (schistosomiasis), and elephantiasis (lymphatic filariasis). Although there have been many studies examining innate immune responses (including TLR expression and function) in response to intracellular pathogens, fewer have examined the interaction of the multicellular helminth parasites and the innate immune system. This review will focus on two 'systemic' helminth parasitic infections (lymphatic filariasis and schistosomiasis) and the regulation of TLRs that may contribute to infection outcome. JF - Immunologic Research AU - Venugopal, Priyanka Goel AU - Nutman, Thomas B AU - Semnani, Roshanak Tolouei AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 126, Bethesda, MD 20892-0425, USA, rsemnani@niaid.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 252 EP - 263 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 43 IS - 1-3 SN - 0257-277X, 0257-277X KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Parasites KW - Cirrhosis KW - Immune system KW - Anemia KW - Filariasis KW - Receptors KW - Disease control KW - Schistosomiasis KW - Pathogens KW - Infection KW - Public health KW - Socio-economic aspects KW - Anaemia KW - Schistosoma KW - Immune response KW - Aquatic insects KW - river blindness KW - Toll-like receptors KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744719202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Activation+and+regulation+of+Toll-Like+Receptors+%28TLRs%29+by+helminth+parasites&rft.au=Venugopal%2C+Priyanka+Goel%3BNutman%2C+Thomas+B%3BSemnani%2C+Roshanak+Tolouei&rft.aulast=Venugopal&rft.aufirst=Priyanka&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8079-0 L2 - http://www.springerlink.com/content/5628101g40057742/?p=f268b15947f84f048300fc1ea0d102b5&pi=21 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Parasites; Anaemia; Disease control; Receptors; Schistosomiasis; Pathogens; Aquatic insects; Public health; Cirrhosis; Immune system; Filariasis; Anemia; Infection; Socio-economic aspects; Immune response; Toll-like receptors; river blindness; Schistosoma DO - http://dx.doi.org/10.1007/s12026-008-8079-0 ER - TY - JOUR T1 - Innate immune recognition of nucleic acids AN - 744699532; 12879021 AB - The innate immune system employs a number of pattern recognition receptor families in response to DNAs and RNAs, either from invading microbes or within the hosts. These include the Toll-like receptors (TLRs), the retinoic acid inducible gene I (RIG-I) like receptors (RLRs), and the nucleotide-binding domain leucine-rich repeat/NOD-like receptor (NLRs), among other potential sensors in the cytoplasm. These receptors are composed of modular domain architecture, with ligand binding/sensing domains and signaling domains regulated either through dimerization/oligomerization, or conformational changes directed by enzymatic activities. Signaling pathways from different families of receptors converge on their respective common adapter proteins and lead to activation of transcription factors or caspases. Many of these receptors induce orchestrated responses to similar ligands from different cell types, resulting in redundant and complementary immunity to infections. This highly efficient defense system is a double-edged sword: inappropriate reaction to host ligands leads to compromised innate tolerance and autoimmune diseases. Structural studies of innate immune receptors and their signaling pathways are essential in our understanding of pattern recognition mechanisms and design of more efficient vaccine adjuvants. JF - Immunologic Research AU - Xiao, Tsan AD - Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Memorial Drive, Building 4, Room 138, Bethesda, MD 20892-0430, USA, Xiaot@niaid.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 98 EP - 108 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 43 IS - 1-3 SN - 0257-277X, 0257-277X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Retinoic acid KW - Immune system KW - Oligomerization KW - Autoimmune diseases KW - Adjuvants KW - Immunity KW - Infection KW - Immunological tolerance KW - Pattern recognition KW - adaptor proteins KW - nucleic acids KW - Cytoplasm KW - Transcription factors KW - Caspase KW - Vaccines KW - Enzymatic activity KW - Toll-like receptors KW - Signal transduction KW - A 01490:Miscellaneous KW - N 14835:Protein-Nucleic Acids Association KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744699532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Innate+immune+recognition+of+nucleic+acids&rft.au=Xiao%2C+Tsan&rft.aulast=Xiao&rft.aufirst=Tsan&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8053-x L2 - http://www.springerlink.com/content/f1jk084825t36t36/?p=80cfe64c784a497d83a909e0c1168af3&pi=7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Retinoic acid; Immune system; Autoimmune diseases; Oligomerization; Immunity; Adjuvants; Infection; Immunological tolerance; Pattern recognition; adaptor proteins; nucleic acids; Transcription factors; Cytoplasm; Caspase; Enzymatic activity; Vaccines; Toll-like receptors; Signal transduction DO - http://dx.doi.org/10.1007/s12026-008-8053-x ER - TY - JOUR T1 - Understanding B cell activation: from single molecule tracking, through Tolls, to stalking memory in malaria AN - 744698431; 12879020 AB - B lymphocyte activation is initiated by the binding of antigens to the clonally expressed B cell receptors (BCRs) triggering signaling cascades that lead to the transcription of a variety of genes associated with B cell activation. Provided with the appropriate T cell help and the microenvironment of germinal centers antigen drives B cells to proliferate and differentiate into long-lived plasma cells and memory B cells that together constitute immunological memory. Here I describe efforts in my laboratory to gain an understanding of the cellular and molecular mechanisms that underlie three processes central to B cell biology namely, the initiation of BCR signaling, the interactions of the BCR with the innate immune system Toll-like receptors, and the generation and maintenance of B cell memory. Such knowledge is likely to aid research efforts in two areas of high public health priority, namely, the development of new therapeutics to control B cell responses in autoimmune disease and the design of effective vaccines to control infectious diseases. JF - Immunologic Research AU - Pierce, Susan K AD - Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, NIAID/NIH/Twinbrook II, 12441 Parklawn Drive, Room 200B, MSC 8180, Rockville, MD 20852, USA, spierce@nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 85 EP - 97 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 43 IS - 1-3 SN - 0257-277X, 0257-277X KW - ASFA Aquaculture Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Molecular modelling KW - Immune system KW - Autoimmune diseases KW - Immunological memory KW - Disease control KW - Malaria KW - Lymphocytes KW - Cell activation KW - Public health KW - Antigens KW - Infectious diseases KW - Lymphocytes T KW - Cytology KW - Germinal centers KW - Lymphocytes B KW - Memory cells KW - Receptors KW - Transcription KW - Drug development KW - Tracking KW - B-cell receptor KW - Microenvironments KW - Vaccines KW - Plasma cells KW - Toll-like receptors KW - Signal transduction KW - Q1 08587:Diseases of Cultured Organisms KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744698431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Understanding+B+cell+activation%3A+from+single+molecule+tracking%2C+through+Tolls%2C+to+stalking+memory+in+malaria&rft.au=Pierce%2C+Susan+K&rft.aulast=Pierce&rft.aufirst=Susan&rft.date=2009-03-01&rft.volume=43&rft.issue=1-3&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-008-8052-y L2 - http://www.springerlink.com/content/p376577337w72310/?p=80cfe64c784a497d83a909e0c1168af3&pi=6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Antigens; Disease control; Receptors; Transcription; Cytology; Vaccines; Lymphocytes; Tracking; Public health; Molecular modelling; Lymphocytes B; Immune system; Autoimmune diseases; Memory cells; Immunological memory; Drug development; Malaria; Cell activation; B-cell receptor; Infectious diseases; Lymphocytes T; Microenvironments; Germinal centers; Plasma cells; Toll-like receptors; Signal transduction DO - http://dx.doi.org/10.1007/s12026-008-8052-y ER - TY - JOUR T1 - 4 Toxicological decision-making on hazards and risks - status quo and way forward. 4.1 Current concepts and schemes of science-driven toxicological decision-making - an overview AN - 744582234; 12614145 JF - Human & Experimental Toxicology AU - Portier, C AD - National Institute of Environmental Health Sciences, North Carolina, USA; Office of Risk Assessment Research, Principal Investigator, Environmental Systems Biology, North Carolina, USA Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 123 EP - 125 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 28 IS - 2-3 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - Decision making KW - Reviews KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744582234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=4+Toxicological+decision-making+on+hazards+and+risks+-+status+quo+and+way+forward.+4.1+Current+concepts+and+schemes+of+science-driven+toxicological+decision-making+-+an+overview&rft.au=Portier%2C+C&rft.aulast=Portier&rft.aufirst=C&rft.date=2009-03-01&rft.volume=28&rft.issue=2-3&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/10.1177%2F0960327109105768 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Decision making; Reviews DO - http://dx.doi.org/10.1177/0960327109105768 ER - TY - JOUR T1 - The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats. AN - 67593638; 19136017 AB - We have previously reported that selective dopamine (DA) D3 receptor antagonists are effective in a number of animal models of drug addiction, but not in intravenous drug self-administration, suggesting a limited ability to modify drug reward. In the present study, we evaluated the actions ofS33138, a novel partially selective D3 receptor antagonist, in animal models relevant to drug addiction. S33138, at doses of 0.156 or 0.625 mg/kg (i.p.), attenuated cocaine-enhanced brain-stimulation reward (BSR), and the highest dose tested (2.5 mg/kg) produced a significant aversive-like rightward shift in BSR rate-frequency reward functions. Further, S33138 produced biphasic effects on cocaine self-administration, i.e., a moderate dose (2.5 mg/kg, p.o.) increased, while a higher dose (5 mg/kg, p.o.) inhibited, cocaine self-administration. The increase in cocaine self-administration likely reflects a compensatory response to a partial reduction in drug reward after S33138. In addition, S33138 (0.156-2.5 mg/kg, p.o.) also dose-dependently inhibited cocaine-induced reinstatement of drug-seeking behavior. The reduction in cocaine-enhanced BSR and cocaine-triggered reinstatement produced by lower effective doses (e.g., 0.156 or 0.625 mg/kg) of 533138 is unlikely due to impaired locomotion, as lower effective doses of S33138 decreased neither Ymax levels in the BSR paradigm, rotarod performance, nor locomotion. However, the higher doses (2.5 or 5 mg/kg) of S33138 also significantly inhibited sucrose self-administration and rotarod performance, suggesting non-D3 receptor-mediated effects on non-drug reward and locomotion. These data suggest that lower doses of S33138 interacting essentially with D3 receptors have pharmacotherapeutic potential in treatment of cocaine addiction, while higher doses occupying D2 receptors may influence locomotion and non-drug reward. JF - Neuropharmacology AU - Peng, Xiao-Qing AU - Ashby, Charles R AU - Spiller, Krista AU - Li, Xia AU - Li, Jie AU - Thomasson, Nitza AU - Millan, Mark J AU - Mocaër, Elisabeth AU - Muńoz, Carmen AU - Gardner, Eliot L AU - Xi, Zheng-Xiong AD - National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 752 EP - 760 VL - 56 IS - 4 KW - Acetanilides KW - 0 KW - Benzopyrans KW - Dopamine Antagonists KW - Dopamine Uptake Inhibitors KW - N-(4-(2-(8-cyano-1,3a,4,9b-tetrahydro(1)benzopyrano(3,4-c)pyrrol-2(3H)-yl)ethyl)phenyl)acetamide KW - Receptors, Dopamine D3 KW - Sucrose KW - 57-50-1 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Reinforcement Schedule KW - Rats, Long-Evans KW - Self Stimulation KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Electric Stimulation KW - Recurrence KW - Postural Balance -- drug effects KW - Rats KW - Self Administration KW - Psychomotor Performance -- drug effects KW - Motor Activity -- drug effects KW - Extinction, Psychological -- drug effects KW - Sucrose -- pharmacology KW - Male KW - Acetanilides -- pharmacology KW - Dopamine Uptake Inhibitors -- antagonists & inhibitors KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Dopamine Antagonists -- pharmacology KW - Receptors, Dopamine D3 -- antagonists & inhibitors KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- drug therapy KW - Benzopyrans -- pharmacology KW - Cocaine -- pharmacology KW - Cocaine -- administration & dosage KW - Dopamine Uptake Inhibitors -- pharmacology KW - Cocaine -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67593638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=The+preferential+dopamine+D3+receptor+antagonist+S33138+inhibits+cocaine+reward+and+cocaine-triggered+relapse+to+drug-seeking+behavior+in+rats.&rft.au=Peng%2C+Xiao-Qing%3BAshby%2C+Charles+R%3BSpiller%2C+Krista%3BLi%2C+Xia%3BLi%2C+Jie%3BThomasson%2C+Nitza%3BMillan%2C+Mark+J%3BMoca%C3%ABr%2C+Elisabeth%3BMu%C5%84oz%2C+Carmen%3BGardner%2C+Eliot+L%3BXi%2C+Zheng-Xiong&rft.aulast=Peng&rft.aufirst=Xiao-Qing&rft.date=2009-03-01&rft.volume=56&rft.issue=4&rft.spage=752&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=1873-7064&rft_id=info:doi/10.1016%2Fj.neuropharm.2008.12.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-17 N1 - Date created - 2009-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2000 Jun;293(3):1063-73 [10869411] Neuropsychopharmacology. 2008 Nov;33(12):2969-80 [18305460] J Neurosci. 2000 Dec 1;20(23):8677-84 [11102473] J Pharmacol Exp Ther. 2001 Apr;297(1):357-63 [11259563] Behav Brain Res. 2001 Jun;121(1-2):189-97 [11275296] Psychopharmacology (Berl). 2001 Dec;158(4):343-59 [11797055] Pharmacol Rev. 2002 Mar;54(1):1-42 [11870259] Psychopharmacology (Berl). 2002 Oct;163(3-4):265-82 [12373428] Neuropsychopharmacology. 2002 Oct;27(4):576-86 [12377394] J Neurosci. 2002 Nov 1;22(21):9595-603 [12417684] Neuropsychopharmacology. 2003 Jun;28(6):1150-9 [12700684] Neuropsychopharmacology. 2003 Jul;28(7):1272-80 [12700694] Brain Res Bull. 2003 Oct 15;61(6):595-601 [14519456] Neuropsychopharmacology. 2004 Apr;29(4):686-93 [14872205] Exp Neurol. 2004 Jul;188(1):128-38 [15191809] Drugs. 2004;64(14):1547-73 [15233592] Science. 1975 Feb 14;187(4176):547-9 [1114313] Behav Neurosci. 1987 Apr;101(2):209-14 [3580122] Ann N Y Acad Sci. 1992 Jun 28;654:400-15 [1632593] Mol Neurobiol. 1995 Aug-Dec;11(1-3):1-19 [8561954] Science. 1996 Mar 15;271(5255):1586-9 [8599115] Psychopharmacology (Berl). 1996 Dec;128(4):351-8 [8986005] Eur Neuropsychopharmacol. 1999 Jan;9(1-2):1-7 [10082221] Pharmacol Biochem Behav. 1999 Jun;63(2):237-43 [10371652] Pharmacol Ther. 2005 Jun;106(3):389-403 [15922019] Brain Res Brain Res Rev. 2005 Jul;49(1):77-105 [15960988] Drug Discov Today. 2005 Jul 1;10(13):917-25 [15993811] Eur J Neurosci. 2005 Jun;21(12):3427-38 [16026480] Neuropharmacology. 2005 Sep;49(4):525-41 [15963538] Pharmacol Ther. 2005 Oct;108(1):18-58 [16183393] J Comp Neurol. 2005 Dec 5;493(1):115-21 [16254990] Neuropsychopharmacology. 2006 Jul;31(7):1393-405 [16205781] Behav Brain Res. 2006 Nov 1;174(1):1-8 [16920204] Int J Neuropsychopharmacol. 2006 Oct;9(5):585-602 [16942635] Eur J Pharmacol. 2007 Mar 22;559(2-3):173-9 [17303116] CNS Drug Rev. 2007 Summer;13(2):240-59 [17627675] J Pharmacol Exp Ther. 2008 Feb;324(2):600-11 [18024787] J Pharmacol Exp Ther. 2008 Feb;324(2):587-99 [18024789] Psychopharmacology (Berl). 2008 Mar;196(4):533-42 [17985117] J Pharmacol Exp Ther. 2008 Mar;324(3):1212-26 [18096759] Therapie. 2008 May-Jun;63(3):187-229 [18718210] J Pharmacol Exp Ther. 2000 Dec;295(3):1223-31 [11082459] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuropharm.2008.12.007 ER - TY - JOUR T1 - Current status and future potential of advanced technologies in radiation oncology. Part 1. Challenges and resources. AN - 67203461; 19418829 AB - In 2006, the Radiation Research Program of the Division of Cancer Treatment and Diagnosis of the National Cancer Institute hosted a workshop intended to address current issues related to advanced radiation therapy technologies, with an eye toward (1) defining the specific toxicities that have limited the success of "conventional" radiation therapy, (2) examining the evidence from phase III studies for the improvements attributed to the advanced technologies in the treatment of several cancers commonly treated with radiation therapy, and (3) determining the opportunities and priorities for further technologic development and clinical trials. The new technologies offer substantial theoretical advantage in radiation dose distributions that, if realized in clinical practice, may help many cancer patients live longer and/or better. The precision of the advanced technologies may allow us to reduce the volume of normal tissue irradiated in the vicinity of the clinical target volume. Part 1 of this two-part article will provide a general overview of the workshop discussion, focusing on the challenges posed by the new technologies and resources available or in development for meeting those challenges. Part 2, which will appear in next month's issue of ONCOLOGY, will address the state of the science for each disease site. JF - Oncology (Williston Park, N.Y.) AU - Vikram, Bhadrasain AU - Coleman, C Norman AU - Deye, James A AD - Clinical Radiation Oncology Branch, Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, Maryland 20852, USA. vikramb@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 279 EP - 283 VL - 23 IS - 3 SN - 0890-9091, 0890-9091 KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Neoplasms -- radiotherapy KW - Radiation Oncology -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67203461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+%28Williston+Park%2C+N.Y.%29&rft.atitle=Current+status+and+future+potential+of+advanced+technologies+in+radiation+oncology.+Part+1.+Challenges+and+resources.&rft.au=Vikram%2C+Bhadrasain%3BColeman%2C+C+Norman%3BDeye%2C+James+A&rft.aulast=Vikram&rft.aufirst=Bhadrasain&rft.date=2009-03-01&rft.volume=23&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Williston+Park%2C+N.Y.%29&rft.issn=08909091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-02 N1 - Date created - 2009-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prognostic factors influencing tumor response, locoregional control and survival, in melanoma patients with multiple limb in-transit metastases treated with TNFalpha-based isolated limb perfusion. AN - 67200028; 19414425 AB - In isolated limb perfusion (ILP) with tumor necrosis factor-alpha (TNFalpha) and interferon (IFN)-gamma, pioneered by Lienard and Lejenne in 1988, TNFalpha was empirically employed at a dosage (3-4 mg) ten times higher than the systemic maximum tolerable dose (MTD). We previously conducted a phase I/II study in 20 patients with in-transit melanoma metastases, using a combination of melphalan and TNFalpha at dosages ranging from 0.5 to 3.3 mg. The dose of 1 mg of TNFalpha was identified as optimal in terms of both efficacy and toxicity. The aim of the present study was to describe our experience with 113 stage IIIA/IIIAB melanoma patients treated with a TNFalpha-based ILP and identify prognostic factors for response, locoregional control and survival. Patients at stage IIIA-IIIAB (presence of in-transit metastases and/or regional node involvement) were considered eligible. The disease was bulky (>or=10 nodules3 cm) in 42.5% of the patients and unresectable in 33% . Forty patients were treated with a TNFalpha dosage of >1 mg and 73 with 1 mg. Patients with tumors in the upper and lower limbs were submitted to ILP via axillary and iliac vessels, respectively. TNFalpha was injected in the arterial line of an extracorporeal circuit at the pre-established dose, followed by melphalan (13 and 10 mg/l of limb volume for the upper and lower limbs, respectively) 30 minutes later. Complete responses (CR) and partial responses (PR) were 63% and 24.5%, respectively, with an objective response (OR) of 87.5%. No change (NC) was observed in only 12.5% of the patients. Upon multivariate analysis, only bulky disease maintained its independent value for tumor response with an odds ratio of 4.07 and a p-value of 0.02. The 5-year locoregional disease-free survival was 42.7%. Upon multivariate analysis, the only prognostic factors were stage, age and bulky disease. The 5-year overall survival was 49%. Multivariate analysis showed that only sex, stage and CR maintained their independent values. TNFalpha-based ILP was proven to be an effective treatment for melanoma patients with in-transit metastases. The TNFalpha dosage of 1 mg was as effective as 3-4 mg, with lower toxicity and cost. We propose that TNFalpha and melphalan-based ILP should be employed for bulky tumors or after failure of melphalan-based ILP. JF - In vivo (Athens, Greece) AU - Di Filippo, F AU - Giacomini, P AU - Rossi, C R AU - Santinami, M AU - Anzà, M AU - Garinei, R AU - Perri, P AU - Botti, C AU - Di Angelo, P AU - Sofra, C AU - Pasqualoni, R AU - Sperduti, I AU - Cavaliere, F AU - Di Filippo, S AU - Corrias, F AU - Armenti, A AU - Ferraresi, V AU - Ginebri, A AD - Department of Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144 Rome, Italy. difilippo@ifo.it PY - 2009 SP - 347 EP - 352 VL - 23 IS - 2 SN - 0258-851X, 0258-851X KW - Tumor Necrosis Factor-alpha KW - 0 KW - Melphalan KW - Q41OR9510P KW - Index Medicus KW - Perfusion KW - Humans KW - Prognosis KW - Aged KW - Melphalan -- pharmacology KW - Extremities KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Neoplasm Metastasis KW - Middle Aged KW - Maximum Tolerated Dose KW - Female KW - Male KW - Melanoma -- pathology KW - Melanoma -- mortality KW - Melanoma -- drug therapy KW - Tumor Necrosis Factor-alpha -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67200028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=Prognostic+factors+influencing+tumor+response%2C+locoregional+control+and+survival%2C+in+melanoma+patients+with+multiple+limb+in-transit+metastases+treated+with+TNFalpha-based+isolated+limb+perfusion.&rft.au=Di+Filippo%2C+F%3BGiacomini%2C+P%3BRossi%2C+C+R%3BSantinami%2C+M%3BAnz%C3%A0%2C+M%3BGarinei%2C+R%3BPerri%2C+P%3BBotti%2C+C%3BDi+Angelo%2C+P%3BSofra%2C+C%3BPasqualoni%2C+R%3BSperduti%2C+I%3BCavaliere%2C+F%3BDi+Filippo%2C+S%3BCorrias%2C+F%3BArmenti%2C+A%3BFerraresi%2C+V%3BGinebri%2C+A&rft.aulast=Di+Filippo&rft.aufirst=F&rft.date=2009-03-01&rft.volume=23&rft.issue=2&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-01 N1 - Date created - 2009-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hyperthermic isolated perfusion with tumor necrosis factor-alpha and doxorubicin for the treatment of limb-threatening soft tissue sarcoma: the experience of the Italian Society of Integrated Locoregional Treatment in Oncology (SITILO). AN - 67197775; 19414428 AB - Tumor necrosis factor-alpha (TNFalpha)-based hyperthermic isolated limb perfusion (HILP) is routinely carried out at most oncological institutions in the treatment of locally advanced soft tissue limb sarcoma (STS), employing high TNFalpha dosages. After a phase I-II study, the SITILO (Italian Society of Integrated Locoregional Therapies in Oncology) centers began to employ the lower dose of 1 mg of TNFalpha. The aim of this paper is to report on the results obtained in 75 patients with limb-threatening STS treated with a low TNFalpha dose and doxorubicin (Dx). HILP with TNFalpha (at a dosage of either 1 mg) and Dx was administered to 75 patients with limb-threatening STS: 37 males and 38 females; median age 50 years; tumor in the lower and upper limbs in 58 and 17 patients, respectively; primary and recurrent tumors in 45 and 30 patients, respectively. Most tumors (77%) were high grade. Tumor resection was carried out 6 to 8 weeks after HILP. The grade of limb toxicity was mild to moderate in the vast majority of patients (76%). Grades IV and V were observed, but only when high muscle temperatures were recorded and high TNFalpha dosages were employed. Systemic toxicity was also mild to moderate and there were no postoperative deaths. Complete and partial tumor responses were 34% and 48%, respectively, with an overall response of 82% . Limb sparing surgery was carried out in 85.3% of patients. At a median follow-up of 28 months, 16 recurrences (21.3%) were recorded, with a 5-year locoregional disease-free survival of 63% . The 5-year disease-free survival and overall survival were 36.7% and 61.6%, respectively. HILP with 1 mg of TNFalpha is an effective neoadjuvant therapy resulting in a high rate of limb sparing in limb-threatening STS, with acceptable local reactions and negligible systemic toxicity. JF - In vivo (Athens, Greece) AU - Di Filippo, F AU - Giacomini, P AU - Rossi, C R AU - Santinami, M AU - Garinei, R AU - Anzà, M AU - Deraco, M AU - Botti, C AU - Perri, P AU - Cavaliere, F AU - Di Angelo, P AU - Sofra, C AU - Sperduti, I AU - Pasqualoni, R AU - Di Filippo, S AU - Corrias, F AU - Armenti, A AU - Ferraresi, V AD - Department of Surgery, Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144 Rome, Italy. difilippo@ifo.it PY - 2009 SP - 363 EP - 367 VL - 23 IS - 2 SN - 0258-851X, 0258-851X KW - Tumor Necrosis Factor-alpha KW - 0 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Disease-Free Survival KW - Perfusion KW - Humans KW - Aged KW - Chemotherapy, Cancer, Regional Perfusion -- methods KW - Recurrence KW - Extremities -- pathology KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Tumor Necrosis Factor-alpha -- administration & dosage KW - Hyperthermia, Induced KW - Soft Tissue Neoplasms -- drug therapy KW - Doxorubicin -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Sarcoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67197775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=Hyperthermic+isolated+perfusion+with+tumor+necrosis+factor-alpha+and+doxorubicin+for+the+treatment+of+limb-threatening+soft+tissue+sarcoma%3A+the+experience+of+the+Italian+Society+of+Integrated+Locoregional+Treatment+in+Oncology+%28SITILO%29.&rft.au=Di+Filippo%2C+F%3BGiacomini%2C+P%3BRossi%2C+C+R%3BSantinami%2C+M%3BGarinei%2C+R%3BAnz%C3%A0%2C+M%3BDeraco%2C+M%3BBotti%2C+C%3BPerri%2C+P%3BCavaliere%2C+F%3BDi+Angelo%2C+P%3BSofra%2C+C%3BSperduti%2C+I%3BPasqualoni%2C+R%3BDi+Filippo%2C+S%3BCorrias%2C+F%3BArmenti%2C+A%3BFerraresi%2C+V&rft.aulast=Di+Filippo&rft.aufirst=F&rft.date=2009-03-01&rft.volume=23&rft.issue=2&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-01 N1 - Date created - 2009-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of chemotherapy in Hodgkin's lymphoma. AN - 67162617; 19390311 AB - The development of curative chemotherapy regimens for the treatment of Hodgkin's lymphoma (HL) is one of the true success stories in oncology. Most patients diagnosed with HL today can be cured. The major task remaining before us is curing as many patients as possible with their initial therapeutic approach while minimizing the acute toxicities and limiting the lifetime risks of important secondary events such as cardiovascular complications and secondary malignancies. In the 40 years since DeVita et al. developed the mechlorethamine, vincristine, procarbazine, and prednisone chemotherapy regimen, we have learned a great deal about risk stratification to minimize treatment-related toxicity. Positron emission tomography may further assist us in reducing radiation treatment without compromising cures. This review will discuss the development of the chemotherapy regimens used in the management of early and advanced stage HL and the advantages and disadvantages of their use in combination with radiation therapy. JF - Cancer journal (Sudbury, Mass.) AU - Seam, Pamela AU - Janik, John E AU - Longo, Dan L AU - Devita, Vincent T AD - Clinical Trials Team, Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. PY - 2009 SP - 150 EP - 154 VL - 15 IS - 2 SN - 1528-9117, 1528-9117 KW - Antineoplastic Agents KW - 0 KW - Radiopharmaceuticals KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Bleomycin KW - 11056-06-7 KW - Vinblastine KW - 5V9KLZ54CY KW - Dacarbazine KW - 7GR28W0FJI KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Humans KW - Prognosis KW - Disease Progression KW - Antineoplastic Combined Chemotherapy Protocols KW - Radionuclide Imaging KW - Hodgkin Disease -- radiotherapy KW - Hodgkin Disease -- pathology KW - Hodgkin Disease -- drug therapy KW - Hodgkin Disease -- diagnostic imaging KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67162617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.atitle=Role+of+chemotherapy+in+Hodgkin%27s+lymphoma.&rft.au=Seam%2C+Pamela%3BJanik%2C+John+E%3BLongo%2C+Dan+L%3BDevita%2C+Vincent+T&rft.aulast=Seam&rft.aufirst=Pamela&rft.date=2009-03-01&rft.volume=15&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.issn=15289117&rft_id=info:doi/10.1097%2FPPO.0b013e3181a27018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-27 N1 - Date created - 2009-04-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2001 Jun 1;19(11):2905-14 [11387364] N Engl J Med. 2007 Nov 8;357(19):1916-27 [17989384] J Clin Oncol. 2002 Feb 1;20(3):630-7 [11821442] J Clin Oncol. 2003 Feb 15;21(4):607-14 [12586796] N Engl J Med. 2003 Jun 12;348(24):2386-95 [12802024] Ann Diagn Pathol. 2003 Oct;7(5):333-4 [14571438] J Clin Oncol. 2004 Jan 1;22(1):62-8 [14657226] Med Ann Dist Columbia. 1967 Apr;36(4):232-4 passim [5232852] Cancer Res. 1971 Nov;31(11):1860-1 [5121694] Ann Intern Med. 1970 Dec;73(6):881-95 [5525541] Cancer. 1975 Jul;36(1):252-9 [54209] Ann Intern Med. 1982 Feb;96(2):139-43 [6174060] Eur J Cancer Clin Oncol. 1985 May;21(5):601-5 [2408897] J Clin Oncol. 1985 Sep;3(9):1174-82 [2411881] Ann Intern Med. 1986 Jun;104(6):739-46 [2422994] J Clin Oncol. 1986 Jun;4(6):830-7 [3711960] J Clin Oncol. 1986 Sep;4(9):1295-306 [3528400] J Clin Oncol. 1987 Jan;5(1):27-37 [2433409] N Engl J Med. 1987 Mar 19;316(12):710-4 [3821809] J Clin Oncol. 1989 Nov;7(11):1630-6 [2809679] J Clin Oncol. 1991 Jun;9(6):906-17 [2033427] N Engl J Med. 1992 Nov 19;327(21):1478-84 [1383821] J Clin Oncol. 1995 May;13(5):1080-8 [7537796] J Clin Oncol. 1996 May;14(5):1421-30 [8622055] Ann Oncol. 1997 Feb;8(2):143-8 [9093722] J Clin Oncol. 1997 Apr;15(4):1638-45 [9193364] J Clin Oncol. 1998 Jan;16(1):19-26 [9440718] J Clin Oncol. 1998 Mar;16(3):818-29 [9508162] J Clin Oncol. 1998 Mar;16(3):830-43 [9508163] N Engl J Med. 1998 Nov 19;339(21):1506-14 [9819449] Blood. 1998 Dec 15;92(12):4560-7 [9845521] Blood. 2004 Dec 1;104(12):3483-9 [15315964] J Clin Oncol. 2005 Jul 20;23(21):4634-42 [15837968] J Clin Oncol. 2005 Dec 20;23(36):9198-207 [16172458] Blood. 2006 Jan 1;107(1):52-9 [16150944] J Clin Oncol. 2006 Jul 1;24(19):3128-35 [16754934] Blood. 2007 Feb 1;109(3):905-9 [17018856] J Clin Oncol. 2007 Aug 10;25(23):3495-502 [17606976] J Clin Oncol. 2007 Aug 20;25(24):3746-52 [17646666] J Clin Oncol. 2001 Nov 15;19(22):4238-44 [11709567] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/PPO.0b013e3181a27018 ER - TY - JOUR T1 - Placebo-controlled trial of rituximab in IgM anti-myelin-associated glycoprotein antibody demyelinating neuropathy. AN - 67107900; 19334068 AB - Report a double-blind, placebo-controlled study of rituximab in patients with anti-MAG demyelinating polyneuropathy (A-MAG-DP). Twenty-six patients were randomized to four weekly infusions of 375 mg/m(2) rituximab or placebo. Sample size was calculated to detect changes of > or = 1 Inflammatory Neuropathy Course and Treatment (INCAT) leg disability scores at month 8. IgM levels, anti-MAG titers, B cells, antigen-presenting cells, and immunoregulatory T cells were monitored every 2 months. Thirteen A-MAG-DP patients were randomized to rituximab and 13 to placebo. Randomization was balanced for age, electrophysiology, disease duration, disability scores, and baseline B cells. After 8 months, by intention to treat, 4 of 13 rituximab-treated patients improved by > or = 1 INCAT score compared with 0 of 13 patients taking placebo (p = 0.096). Excluding one rituximab-randomized patient who had normal INCAT score at entry, and thus could not improve, the results were significant (p = 0.036). The time to 10m walk was significantly reduced in the rituximab group (p = 0.042) (intention to treat). Clinically, walking improved in 7 of 13 rituximab-treated patients. At month 8, IgM was reduced by 34% and anti-MAG titers by 50%. CD25+CD4+Foxp3+ regulatory cells significantly increased by month 8. The most improved patients were those with high anti-MAG titers and most severe sensory deficits at baseline. Rituximab is the first drug that improves some patients with A-MAG-DP in a controlled study. The benefit may be exerted by reducing the putative pathogenic antibodies or by inducing immunoregulatory T cells. The results warrant confirmation with a larger trial. JF - Annals of neurology AU - Dalakas, Marinos C AU - Rakocevic, Goran AU - Salajegheh, Mohammad AU - Dambrosia, James M AU - Hahn, Angelika F AU - Raju, Raghavan AU - McElroy, Beverly AD - Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. m.dalakas@imperial.ac.uk Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 286 EP - 293 VL - 65 IS - 3 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Murine-Derived KW - Immunoglobulin M KW - Immunologic Factors KW - Myelin-Associated Glycoprotein KW - Rituximab KW - 4F4X42SYQ6 KW - Index Medicus KW - B-Lymphocytes -- drug effects KW - Double-Blind Method KW - Humans KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - T-Lymphocytes -- drug effects KW - Seveso Accidental Release KW - Male KW - Female KW - Demyelinating Diseases -- complications KW - Immunoglobulin M -- blood KW - Immunologic Factors -- therapeutic use KW - Demyelinating Diseases -- immunology KW - Myelin-Associated Glycoprotein -- immunology KW - Polyneuropathies -- complications KW - Polyneuropathies -- immunology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67107900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+neurology&rft.atitle=Placebo-controlled+trial+of+rituximab+in+IgM+anti-myelin-associated+glycoprotein+antibody+demyelinating+neuropathy.&rft.au=Dalakas%2C+Marinos+C%3BRakocevic%2C+Goran%3BSalajegheh%2C+Mohammad%3BDambrosia%2C+James+M%3BHahn%2C+Angelika+F%3BRaju%2C+Raghavan%3BMcElroy%2C+Beverly&rft.aulast=Dalakas&rft.aufirst=Marinos&rft.date=2009-03-01&rft.volume=65&rft.issue=3&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Annals+of+neurology&rft.issn=1531-8249&rft_id=info:doi/10.1002%2Fana.21577 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-23 N1 - Date created - 2009-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ana.21577 ER - TY - JOUR T1 - Five-year experience of human papillomavirus DNA and Papanicolaou test cotesting. AN - 67047912; 19300322 AB - To estimate the 5-year age group-specific test positives for Pap tests and human papillomavirus (HPV) testing in a large, general screening population of women 30 and older. Using data from Kaiser Permanente Northern California, a large health maintenance organization that introduced cotesting in 2003, we evaluated the cotesting results overall and by 5-year age groups. Women (n=580,289) who opted for and underwent cotesting (n cotests=812,598) between January 2003 and April 2008 were included in the analysis. Pap tests interpreted as atypical squamous cells of undetermined significance (ASC-US) or more severe were considered to be positive. Women were tested for carcinogenic HPV using an assay approved by the U.S. Food and Drug Administration. Binomial exact 95% confidence intervals (CIs) were calculated. Overall, 6.27% (95% CI 6.21-6.32%) of cotests were carcinogenic HPV positive, and only 3.99% (95% CI 3.94-4.03%) cotests had normal cytology and were carcinogenic HPV positive. By comparison, 5.18% (95% CI 5.13-5.23%) of cotests had ASC-US or more severe cytology, and 2.87% (95% CI 2.84-2.91%) of cotests had ASC-US or more severe cytology and were carcinogenic HPV negative. In a general screening population, concerns about excessive HPV test positives among women aged 30 years and older are not borne out. JF - Obstetrics and gynecology AU - Castle, Philip E AU - Fetterman, Barbara AU - Poitras, Nancy AU - Lorey, Thomas AU - Shaber, Ruth AU - Kinney, Walter AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 595 EP - 600 VL - 113 IS - 3 SN - 0029-7844, 0029-7844 KW - DNA, Viral KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - DNA, Viral -- analysis KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Papillomaviridae -- genetics KW - Middle Aged KW - Female KW - Comorbidity KW - Papillomavirus Infections -- epidemiology KW - Papillomavirus Infections -- diagnosis KW - Uterine Cervical Neoplasms -- epidemiology KW - Uterine Cervical Neoplasms -- diagnosis KW - Mass Screening -- methods KW - Vaginal Smears -- methods KW - Uterine Cervical Neoplasms -- virology KW - Papanicolaou Test UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67047912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Five-year+experience+of+human+papillomavirus+DNA+and+Papanicolaou+test+cotesting.&rft.au=Castle%2C+Philip+E%3BFetterman%2C+Barbara%3BPoitras%2C+Nancy%3BLorey%2C+Thomas%3BShaber%2C+Ruth%3BKinney%2C+Walter&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2009-03-01&rft.volume=113&rft.issue=3&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/10.1097%2FAOG.0b013e3181996ffa LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-14 N1 - Date created - 2009-03-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2002 Apr 24;287(16):2120-9 [11966387] Lancet Oncol. 2008 Oct;9(10):937-45 [18783988] CA Cancer J Clin. 2002 Nov-Dec;52(6):342-62 [12469763] J Natl Cancer Inst. 2003 Jan 1;95(1):46-52 [12509400] Am J Obstet Gynecol. 2003 Jun;188(6):1383-92 [12824967] Am J Obstet Gynecol. 2003 Jun;188(6):1393-400 [12824968] N Engl J Med. 2003 Oct 16;349(16):1501-9 [14561792] Obstet Gynecol. 2004 Feb;103(2):304-9 [14754700] Am J Clin Pathol. 2004 Aug;122(2):238-45 [15323141] JAMA. 1994 Jun 15;271(23):1866-9 [8196145] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Am J Clin Pathol. 2005 Nov;124(5):716-21 [16203283] Lancet. 2006 Feb 11;367(9509):489-98 [16473126] Int J Cancer. 2006 Sep 1;119(5):1095-101 [16586444] Vaccine. 2006 Aug 31;24 Suppl 3:S3/63-70 [16950019] Vaccine. 2006 Aug 31;24 Suppl 3:S3/78-89 [16950021] Cancer Res. 2006 Nov 1;66(21):10630-6 [17062559] JAMA. 2007 Feb 28;297(8):813-9 [17327523] Obstet Gynecol. 2007 Jun;109(6):1325-31 [17540804] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] Am J Obstet Gynecol. 2007 Oct;197(4):356.e1-6 [17904958] N Engl J Med. 2007 Oct 18;357(16):1579-88 [17942871] N Engl J Med. 2007 Oct 18;357(16):1589-97 [17942872] Lancet. 2007 Nov 24;370(9601):1764-72 [17919718] Obstet Gynecol. 2008 Jan;111(1):2-3 [18165385] Obstet Gynecol. 2008 Jan;111(1):167-77 [18165406] Ann Intern Med. 2008 Apr 1;148(7):493-500 [18378945] Ann Intern Med. 2008 Apr 1;148(7):557-9 [18378951] Am J Epidemiol. 2008 Jul 15;168(2):138-44; discussion 145-8 [18483124] Arch Pathol Lab Med. 2008 Aug;132(8):1290-4 [18684028] BMJ. 2008;337:a1284 [18801868] BMJ. 2008;337:a1343 [18801869] Virus Res. 2002 Nov;89(2):263-9 [12445665] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/AOG.0b013e3181996ffa ER - TY - JOUR T1 - The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. AN - 67031484; 19282983 AB - HIV-1 release is mediated through two motifs in the p6 region of Gag, PTAP and LYPX(n)L, which recruit cellular proteins Tsg101 and Alix, respectively. The Nucleocapsid region of Gag (NC), which binds the Bro1 domain of Alix, also plays an important role in HIV-1 release, but the underlying mechanism remains unclear. Here we show that the first 202 residues of the Bro1 domain (Bro(i)) are sufficient to bind Gag. Bro(i) interferes with HIV-1 release in an NC-dependent manner and arrests viral budding at the plasma membrane. Similar interrupted budding structures are seen following over-expression of a fragment containing Bro1 with the adjacent V domain (Bro1-V). Although only Bro1-V contains binding determinants for CHMP4, both Bro(i) and Bro1-V inhibited release via both the PTAP/Tsg101 and the LYPX(n)L/Alix pathways, suggesting that they interfere with a key step in HIV-1 release. Remarkably, we found that over-expression of Bro1 rescued the release of HIV-1 lacking both L domains. This rescue required the N-terminal region of the NC domain in Gag and the CHMP4 binding site in Bro1. Interestingly, release defects due to mutations in NC that prevented Bro1 mediated rescue of virus egress were rescued by providing a link to the ESCRT machinery via Nedd4.2s over-expression. Our data support a model in which NC cooperates with PTAP in the recruitment of cellular proteins necessary for its L domain activity and binds the Bro1-CHMP4 complex required for LYPX(n)L-mediated budding. JF - PLoS pathogens AU - Dussupt, Vincent AU - Javid, Melodi P AU - Abou-Jaoudé, Georges AU - Jadwin, Joshua A AU - de La Cruz, Jason AU - Nagashima, Kunio AU - Bouamr, Fadila AD - Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 1 VL - 5 IS - 3 KW - Calcium-Binding Proteins KW - 0 KW - Cell Cycle Proteins KW - DNA-Binding Proteins KW - Endosomal Sorting Complexes Required for Transport KW - PDCD6IP protein, human KW - Transcription Factors KW - Tsg101 protein KW - Viral Proteins KW - gag Gene Products, Human Immunodeficiency Virus KW - Index Medicus KW - Transcription Factors -- metabolism KW - Humans KW - DNA-Binding Proteins -- genetics KW - Immunoprecipitation KW - Transcription Factors -- genetics KW - Cell Cycle Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Polymerase Chain Reaction KW - Blotting, Western KW - Amino Acid Motifs KW - Cell Cycle Proteins -- genetics KW - Transfection KW - Calcium-Binding Proteins -- genetics KW - Calcium-Binding Proteins -- metabolism KW - Fluorescent Antibody Technique KW - DNA-Binding Proteins -- metabolism KW - Viral Proteins -- genetics KW - gag Gene Products, Human Immunodeficiency Virus -- genetics KW - Nucleocapsid -- metabolism KW - Nucleocapsid -- genetics KW - Viral Proteins -- metabolism KW - HIV-1 -- physiology KW - gag Gene Products, Human Immunodeficiency Virus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67031484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+pathogens&rft.atitle=The+nucleocapsid+region+of+HIV-1+Gag+cooperates+with+the+PTAP+and+LYPXnL+late+domains+to+recruit+the+cellular+machinery+necessary+for+viral+budding.&rft.au=Dussupt%2C+Vincent%3BJavid%2C+Melodi+P%3BAbou-Jaoud%C3%A9%2C+Georges%3BJadwin%2C+Joshua+A%3Bde+La+Cruz%2C+Jason%3BNagashima%2C+Kunio%3BBouamr%2C+Fadila&rft.aulast=Dussupt&rft.aufirst=Vincent&rft.date=2009-03-01&rft.volume=5&rft.issue=3&rft.spage=e1000339&rft.isbn=&rft.btitle=&rft.title=PLoS+pathogens&rft.issn=1553-7374&rft_id=info:doi/10.1371%2Fjournal.ppat.1000339 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-12 N1 - Date created - 2009-03-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Med. 2001 Dec;7(12):1313-9 [11726971] Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):955-60 [11805336] Trends Microbiol. 2002 May;10(5):203-5 [11973141] J Virol. 2002 Jun;76(11):5472-9 [11991975] Dev Cell. 2002 Aug;3(2):271-82 [12194857] J Virol. 2002 Dec;76(23):11853-65 [12414928] J Biol Chem. 2002 Nov 15;277(46):43924-32 [12221077] J Virol. 2003 Apr;77(8):4794-804 [12663786] J Cell Sci. 2003 May 15;116(Pt 10):1893-903 [12668726] J Virol. 2003 May;77(10):5547-56 [12719547] Biochemistry. 2003 Jun 3;42(21):6408-17 [12767222] Cell. 2003 Sep 19;114(6):689-99 [14505569] J Virol. 1993 Oct;67(10):6159-69 [8371356] J Virol. 1994 Apr;68(4):2556-69 [8139035] J Virol. 1995 Sep;69(9):5455-60 [7636991] J Virol. 1995 Oct;69(10):6487-97 [7666550] J Virol. 1995 Nov;69(11):6810-8 [7474093] EMBO J. 1997 Apr 15;16(8):1820-31 [9155008] EMBO J. 1998 Jun 1;17(11):2982-93 [9606181] Trends Biochem Sci. 1998 Aug;23(8):297-301 [9757830] Virology. 1998 Nov 10;251(1):1-15 [9813197] J Biol Chem. 1999 Jan 15;274(3):1533-40 [9880530] Science. 2007 Jun 29;316(5833):1908-12 [17556548] EMBO J. 2007 Oct 3;26(19):4215-27 [17853893] Nature. 2007 Oct 11;449(7163):740-4 [17928862] Cell Host Microbe. 2007 Mar 15;1(1):5-7 [18005675] Nat Struct Mol Biol. 2008 Jan;15(1):43-9 [18066081] J Virol. 2008 Feb;82(3):1389-98 [18032513] J Cell Biol. 2008 Jan 28;180(2):389-402 [18209100] FEBS J. 2008 Feb;275(4):682-92 [18190528] Cell. 2003 Sep 19;114(6):701-13 [14505570] Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12414-9 [14519844] J Virol. 2003 Nov;77(22):12373-7 [14581576] J Virol. 2004 Jan;78(2):716-23 [14694103] J Virol. 2004 Jan;78(2):724-32 [14694104] J Virol. 2004 Jun;78(11):5554-63 [15140952] J Biol Chem. 2004 Aug 20;279(34):36059-71 [15218037] Annu Rev Cell Dev Biol. 2004;20:395-425 [15473846] J Virol. 1986 Aug;59(2):284-91 [3016298] J Virol. 1988 Feb;62(2):633-6 [3336071] Proc Natl Acad Sci U S A. 1990 Jan;87(2):523-7 [2405382] J Virol. 1990 Jun;64(6):2743-50 [1692347] Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3195-9 [2014240] J Virol. 1993 Jul;67(7):4027-36 [8510214] Curr Opin Struct Biol. 2008 Apr;18(2):203-17 [18406133] J Virol. 2008 May;82(10):4884-97 [18321968] J Virol. 2008 May;82(10):4898-907 [18321969] Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6308-13 [18434552] Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7687-91 [18511562] Dev Cell. 2008 Jul;15(1):62-73 [18606141] J Virol. 2000 Apr;74(7):3046-57 [10708419] J Virol. 2000 Jun;74(12):5395-402 [10823843] J Virol. 2000 Aug;74(16):7250-60 [10906179] J Virol. 2000 Sep;74(18):8670-9 [10954568] J Virol. 1999 Mar;73(3):2270-9 [9971810] Cell Death Differ. 1999 Feb;6(2):124-9 [10200558] Virus Res. 2004 Dec;106(2):87-102 [15567490] J Biol Chem. 2005 Apr 1;280(13):12799-809 [15632132] Biosci Biotechnol Biochem. 2005 Apr;69(4):861-5 [15849434] Dev Cell. 2005 Jun;8(6):937-47 [15935782] J Virol. 2005 Jul;79(14):9038-45 [15994797] J Cell Sci. 2005 Jul 15;118(Pt 14):3003-17 [16014378] Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13813-8 [16174732] Nature. 2005 Dec 1;438(7068):590-6 [16319878] J Biol Chem. 2005 Dec 9;280(49):40474-80 [16215227] Virology. 2006 Jan 5;344(1):55-63 [16364736] J Cell Sci. 2006 Aug 1;119(Pt 15):3025-32 [16868030] Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19140-5 [17146056] Arch Biochem Biophys. 2007 Jan 15;457(2):142-9 [17174262] J Biol Chem. 2007 Feb 9;282(6):3847-55 [17158451] J Virol. 2007 Mar;81(6):2909-22 [17182674] Nat Struct Mol Biol. 2007 Mar;14(3):194-9 [17277784] Cell. 2007 Mar 9;128(5):841-52 [17350572] J Virol. 2007 Apr;81(7):3317-26 [17229703] Cell. 2007 May 4;129(3):485-98 [17442384] J Virol. 2007 Jun;81(12):6614-22 [17428861] J Virol. 2000 Oct;74(19):8980-8 [10982342] Traffic. 2000 Mar;1(3):248-58 [11208108] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7724-9 [11427703] Cell. 2001 Jul 27;106(2):145-55 [11511343] J Cell Sci. 2001 Jul;114(Pt 13):2395-404 [11559748] Cell. 2001 Oct 5;107(1):55-65 [11595185] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.ppat.1000339 ER - TY - JOUR T1 - Obesity and weight gain in adulthood and telomere length. AN - 67014711; 19273484 AB - Obesity and weight gain in adulthood are associated with an increased risk of several cancers. Telomeres play a critical role in maintaining genomic integrity and may be involved in carcinogenesis. Using data from 647 women ages 35 to 74 years in the United States and Puerto Rico (2003-2004), we examined the association between current and past anthropometric characteristics and telomere length in blood. In a multivariate linear regression model, higher current body mass index (BMI) and hip circumference were inversely associated with telomere length. Higher BMI in the 30s was associated with shorter telomere length among women ages>or=40 years (Ptrend<0.01). Weight gain since the age 30s (Ptrend=0.07) and weight cycling (Ptrend=0.04) were also inversely associated with telomere length. When current BMI and BMI at ages 30 to 39 years were considered together, the most marked decrease in telomere length was found for women who had overweight or obese BMI at both time points (mean telomere repeat copy number to single-copy gene copy number ratio=1.26; 95% confidence interval, 1.21-1.30) compared with women who had normal BMI at both times (mean telomere repeat copy number to single-copy gene copy number ratio=1.33; 95% confidence interval, 1.30-1.36). These findings support the hypothesis that obesity may accelerate aging, and highlight the importance of maintaining a desirable weight in adulthood. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Kim, Sangmi AU - Parks, Christine G AU - DeRoo, Lisa A AU - Chen, Honglei AU - Taylor, Jack A AU - Cawthon, Richard M AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, P.O. Box 12233, MD A3-05, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 816 EP - 820 VL - 18 IS - 3 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Age Factors KW - Humans KW - Linear Models KW - Aged KW - Body Mass Index KW - Anthropometry KW - Prospective Studies KW - Puerto Rico KW - Risk Factors KW - Adult KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Breast Neoplasms -- genetics KW - Obesity -- genetics KW - Telomere KW - Weight Gain -- genetics KW - Breast Neoplasms -- epidemiology KW - Obesity -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67014711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Obesity+and+weight+gain+in+adulthood+and+telomere+length.&rft.au=Kim%2C+Sangmi%3BParks%2C+Christine+G%3BDeRoo%2C+Lisa+A%3BChen%2C+Honglei%3BTaylor%2C+Jack+A%3BCawthon%2C+Richard+M%3BSandler%2C+Dale+P&rft.aulast=Kim&rft.aufirst=Sangmi&rft.date=2009-03-01&rft.volume=18&rft.issue=3&rft.spage=816&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0935 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-16 N1 - Date created - 2009-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nutrition. 2001 Nov-Dec;17(11-12):953-66 [11744348] Obesity (Silver Spring). 2008 Dec;16(12):2682-9 [18820651] Trends Biochem Sci. 2002 Jul;27(7):339-44 [12114022] J Nutr. 2003 Mar;133 Suppl 3:933S-940S [12612179] J Natl Cancer Inst. 2003 Aug 20;95(16):1211-8 [12928346] Obes Res. 2004 Jul;12(7):1094-103 [15292473] J Health Soc Behav. 1983 Dec;24(4):385-96 [6668417] Epidemiology. 1995 Jan;6(1):61-6 [7888448] FEBS Lett. 1997 Nov 17;417(3):349-51 [9409749] J Clin Invest. 2004 Dec;114(12):1752-61 [15599400] Circulation. 2005 May 3;111(17):2171-7 [15851602] Curr Mol Med. 2005 Mar;5(2):197-203 [15974873] Am J Epidemiol. 2005 Aug 1;162(3):229-37 [15987723] Lancet. 2005 Aug 20-26;366(9486):662-4 [16112303] J Clin Endocrinol Metab. 2006 Feb;91(2):635-40 [16303830] Aging Cell. 2006 Aug;5(4):325-30 [16913878] Am J Epidemiol. 2007 Jan 1;165(1):14-21 [17043079] Lancet. 2007 Jan 13;369(9556):107-14 [17223473] Cancer Res. 2007 Jun 1;67(11):5538-44 [17545637] Am J Epidemiol. 2007 Aug 15;166(4):447-55 [17556763] Br J Cancer. 2007 Dec 17;97(12):1696-700 [18000505] PLoS Genet. 2008 Feb;4(2):e37 [18282113] Cancer Res. 2008 May 15;68(10):3618-23 [18483243] Nucleic Acids Res. 2002 May 15;30(10):e47 [12000852] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0935 ER - TY - JOUR T1 - A screening study of thyroid cancer and other thyroid diseases among individuals exposed in utero to iodine-131 from Chernobyl fallout. AN - 66998832; 19106267 AB - Like stable iodine, radioiodines concentrate in the thyroid gland, increasing thyroid cancer risk in exposed children. Data on exposure to the embryonic/fetal thyroid are rare, raising questions about use of iodine 131 (I-131) in pregnant women. We present here estimated risks of thyroid disease from exposure in utero to I-131 fallout from the Chernobyl nuclear accident. We conducted a cross-sectional thyroid screening study (palpation, ultrasound, thyroid hormones, and, if indicated, fine needle aspiration) from 2003 to 2006. Participants were 2582 mother-child pairs from Ukraine in which the mother had been pregnant at the time of the accident on April 26, 1986, or 2 months after the time during which I-131 fallout was still present (1494 from contaminated areas, 1088 in the comparison group). Individual cumulative in utero thyroid dose estimates were derived from estimated I-131 activity in the mother's thyroid (mean 72 mGy; range 0-3230 mGy). There were seven cases of thyroid carcinoma and one case of Hurthle cell neoplasm identified as a result of the screening. Whereas the estimated excess odds ratio per gray for thyroid carcinoma was elevated (excess odds ratio per gray 11.66), it was not statistically significant (P = 0.12). No radiation risks were identified for other thyroid diseases. Our results suggest that in utero exposure to radioiodines may have increased the risk of thyroid carcinoma approximately 20 yr after the Chernobyl accident, supporting a conservative approach to medical uses of I-131 during pregnancy. JF - The Journal of clinical endocrinology and metabolism AU - Hatch, M AU - Brenner, A AU - Bogdanova, T AU - Derevyanko, A AU - Kuptsova, N AU - Likhtarev, I AU - Bouville, A AU - Tereshchenko, V AU - Kovgan, L AU - Shpak, V AU - Ostroumova, E AU - Greenebaum, E AU - Zablotska, L AU - Ron, E AU - Tronko, M AD - Chernobyl Research Unit, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, EPS 7098, Rockville, Maryland 20852, USA. hatchm@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 899 EP - 906 VL - 94 IS - 3 KW - Iodine Radioisotopes KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Radiation Dosage KW - Cross-Sectional Studies KW - Humans KW - Adult KW - Dose-Response Relationship, Radiation KW - Adolescent KW - Male KW - Female KW - Pregnancy KW - Fetus -- radiation effects KW - Chernobyl Nuclear Accident KW - Neoplasms, Radiation-Induced -- etiology KW - Iodine Radioisotopes -- adverse effects KW - Thyroid Diseases -- etiology KW - Thyroid Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66998832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=A+screening+study+of+thyroid+cancer+and+other+thyroid+diseases+among+individuals+exposed+in+utero+to+iodine-131+from+Chernobyl+fallout.&rft.au=Hatch%2C+M%3BBrenner%2C+A%3BBogdanova%2C+T%3BDerevyanko%2C+A%3BKuptsova%2C+N%3BLikhtarev%2C+I%3BBouville%2C+A%3BTereshchenko%2C+V%3BKovgan%2C+L%3BShpak%2C+V%3BOstroumova%2C+E%3BGreenebaum%2C+E%3BZablotska%2C+L%3BRon%2C+E%3BTronko%2C+M&rft.aulast=Hatch&rft.aufirst=M&rft.date=2009-03-01&rft.volume=94&rft.issue=3&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=1945-7197&rft_id=info:doi/10.1210%2Fjc.2008-2049 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-07 N1 - Date created - 2009-03-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2006 Jul 5;98(13):897-903 [16818853] Radiat Res. 2006 Jul;166(1 Pt 2):271-86 [16808613] Radiat Res. 2006 Aug;166(2):367-74 [16881738] Cytopathology. 2006 Oct;17(5):245-50 [16961652] Health Phys. 2007 Nov;93(5):487-501 [18049225] Endocr J. 2008 Mar;55(1):135-42 [18219180] J Natl Cancer Inst. 2008 Mar 19;100(6):428-36 [18334707] J Clin Endocrinol Metab. 2008 May;93(5):1641-8 [18319305] J Clin Endocrinol Metab. 2000 Nov;85(11):4367-72 [11095481] Phys Med Biol. 2001 Nov;46(11):2773-83 [11720346] Ann ICRP. 2001;31(1-3):19-515 [11730884] Nat Rev Cancer. 2002 Jul;2(7):543-9 [12094241] Food Nutr Bull. 2002 Sep;23(3 Suppl):87-94 [12362821] Radiat Prot Dosimetry. 2003;105(1-4):265-8 [14526968] Radiat Res. 2004 Apr;161(4):373-9 [15038761] Radiat Res. 2004 Apr;161(4):481-92 [15038762] J Nucl Med. 1967 Mar;8(3):157-65 [6024129] Cancer. 1994 Jul 15;74(2):748-66 [8033057] Health Phys. 1996 Apr;70(4):559-62 [8617598] Radiat Res. 1997 Apr;147(4):422-30 [9092921] Ciba Found Symp. 1997;203:155-64; discussion 164-6 [9339316] Thyroid. 1999 Jul;9(7):721-6 [10447020] Radiat Res. 2005 Feb;163(2):125-36 [15658887] J Natl Cancer Inst. 2005 May 18;97(10):724-32 [15900042] Thyroid. 2005 Nov;15(11):1291-7 [16356095] J Clin Endocrinol Metab. 2006 Jul;91(7):2672-7 [16670159] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/jc.2008-2049 ER - TY - JOUR T1 - Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. AN - 66980764; 19204058 AB - Postnatal steroid use decreases lung inflammation but increases impairment. We hypothesized that increased dose is associated with increased neurodevelopmental impairment, lower postmenstrual age at exposure increases impairment, and risk of bronchopulmonary dysplasia modifies the effect of postnatal corticosteroid. Steroid dose and timing of exposure beyond 7 days was assessed among 2358 extremely low birth weight infants nested in a prospective trial, with 1667 (84%) survivors examined at 18 to 22 months' postmenstrual age. Logistic regression tested the relationship between impairment (Bayley Mental Developmental Index/Psychomotor Developmental Index of /=1.9 mg/kg), and postmenstrual age at first dose. Separate logistic regression tested effect modification according to bronchopulmonary dysplasia severity (Romagnoli risk > 0.5 as high risk, n = 2336 (99%) for days of life 4-7). Three hundred sixty-six (16%) neonates were steroid-treated (94% dexamethasone). Treated neonates were smaller and less mature; 72% of those treated were at high risk for bronchopulmonary dysplasia. Exposure was associated with neurodevelopmental impairment/death. Impairment increased with higher dose; 71% dead or impaired at highest dose tertile. Each 1 mg/kg dose was associated with a 2.0-point reduction on the Mental Developmental Index and a 40% risk increase for disabling cerebral palsy. Older age did not mitigate the harm. Treatment after 33 weeks' postmenstrual age was associated with greatest harm despite not receiving the highest dose. The relationship between steroid exposure and impairment was modified by the bronchopulmonary dysplasia risk, with those at highest risk experiencing less harm. Higher steroid dose was associated with increased neurodevelopmental impairment. There is no "safe" window for steroid use in extremely low birth weight infants. Neonates with low bronchopulmonary dysplasia risk should not be exposed. A randomized trial of steroid use in infants at highest risk is warranted. JF - Pediatrics AU - Wilson-Costello, Deanne AU - Walsh, Michele C AU - Langer, John C AU - Guillet, Ronnie AU - Laptook, Abbot R AU - Stoll, Barbara J AU - Shankaran, Seetha AU - Finer, Neil N AU - Van Meurs, Krisa P AU - Engle, William A AU - Das, Abhik AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network AD - Rainbow Babies and Children's Hospital, Division of Neonatology, 11100 Euclid Ave, Cleveland, OH 44106, USA. ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Y1 - 2009/03// PY - 2009 DA - March 2009 SP - e430 EP - e437 VL - 123 IS - 3 KW - Anti-Inflammatory Agents KW - 0 KW - Dexamethasone KW - 7S5I7G3JQL KW - Abridged Index Medicus KW - Index Medicus KW - Infant KW - Prospective Studies KW - Survival Rate KW - Dose-Response Relationship, Drug KW - Humans KW - Gestational Age KW - Cohort Studies KW - Infant, Newborn KW - Follow-Up Studies KW - Developmental Disabilities -- chemically induced KW - Bronchopulmonary Dysplasia -- mortality KW - Sensation Disorders -- mortality KW - Anti-Inflammatory Agents -- adverse effects KW - Sensation Disorders -- diagnosis KW - Dexamethasone -- administration & dosage KW - Anti-Inflammatory Agents -- administration & dosage KW - Cerebral Palsy -- mortality KW - Sensation Disorders -- chemically induced KW - Dexamethasone -- adverse effects KW - Cerebral Palsy -- diagnosis KW - Developmental Disabilities -- diagnosis KW - Bronchopulmonary Dysplasia -- prevention & control KW - Infant, Extremely Low Birth Weight KW - Cerebral Palsy -- chemically induced KW - Developmental Disabilities -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66980764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Impact+of+postnatal+corticosteroid+use+on+neurodevelopment+at+18+to+22+months%27+adjusted+age%3A+effects+of+dose%2C+timing%2C+and+risk+of+bronchopulmonary+dysplasia+in+extremely+low+birth+weight+infants.&rft.au=Wilson-Costello%2C+Deanne%3BWalsh%2C+Michele+C%3BLanger%2C+John+C%3BGuillet%2C+Ronnie%3BLaptook%2C+Abbot+R%3BStoll%2C+Barbara+J%3BShankaran%2C+Seetha%3BFiner%2C+Neil+N%3BVan+Meurs%2C+Krisa+P%3BEngle%2C+William+A%3BDas%2C+Abhik%3BEunice+Kennedy+Shriver+National+Institute+of+Child+Health+and+Human+Development+Neonatal+Research+Network&rft.aulast=Wilson-Costello&rft.aufirst=Deanne&rft.date=2009-03-01&rft.volume=123&rft.issue=3&rft.spage=e430&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2008-1928 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-30 N1 - Date created - 2009-03-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Pediatrics. 1999 Nov;104(5):e63 [10545589] Pediatrics. 2002 Feb;109(2):330-8 [11826218] Arch Dis Child Fetal Neonatal Ed. 2000 Nov;83(3):F177-81 [11040164] N Engl J Med. 2001 Jan 11;344(2):95-101 [11150359] Pediatrics. 2001 Feb;107(2):217-21 [11158449] Neurotoxicol Teratol. 2001 Jan-Feb;23(1):57-69 [11274876] Pediatrics. 2001 Aug;108(2):E35 [11483845] J Perinatol. 2001 Jun;21(4):242-7 [11533841] Pediatrics. 2001 Sep;108(3):741-8 [11533345] Pediatrics. 2002 Aug;110(2 Pt 1):275-9 [12165578] Cochrane Database Syst Rev. 2003;(1):CD001144 [12535400] Cochrane Database Syst Rev. 2003;(1):CD001146 [12535402] Pediatrics. 2003 Apr;111(4 Pt 2):e534-41 [12671173] Acta Paediatr. 2003 Jul;92(7):827-35 [12892163] Acta Paediatr. 2003 Aug;92(8):888-9 [12948061] Acta Paediatr. 2003 Aug;92(8):948-51 [12948071] J Perinatol. 2003 Sep;23(6):451-6 [13679930] BMC Pediatr. 2001;1:1 [11248841] Pediatrics. 2003 Nov;112(5):e359 [14595077] N Engl J Med. 2004 Mar 25;350(13):1304-13 [15044641] Ann Surg. 1978 Jan;187(1):1-7 [413500] J Pediatr. 1978 Apr;92(4):529-34 [305471] Am J Ophthalmol. 1982 Dec;94(6):744-9 [6897494] Arch Dis Child. 1989 Apr;64(4 Spec No):496-502 [2730118] Pediatrics. 1993 May;91(5):969-75 [8474818] Exp Neurol. 1996 Jul;140(1):43-52 [8682178] Ann N Y Acad Sci. 1997 Aug 14;823:201-13 [9292046] Endocr Rev. 1998 Jun;19(3):269-301 [9626555] Intensive Care Med. 1998 May;24(5):476-80 [9660264] Pediatrics. 1999 Jul;104(1 Pt 1):15-21 [10390254] Pediatr Pulmonol. 1999 Sep;28(3):167-74 [10495332] Dev Med Child Neurol. 1964 Jun;6:295-7 [14155190] Am J Perinatol. 2005 Feb;22(2):77-81 [15731985] Pediatrics. 2005 Mar;115(3):655-61 [15741368] Pediatrics. 2005 Mar;115(3):681-7 [15741372] Pediatrics. 2005 Jul;116(1):1-7 [15995023] Arch Ophthalmol. 2005 Jul;123(7):991-9 [16009843] Neuropsychopharmacology. 2006 Jan;31(1):12-35 [15920497] Pediatrics. 2006 Jan;117(1):75-83 [16396863] J Matern Fetal Neonatal Med. 2006 Jan;19(1):43-8 [16492591] Neuropsychopharmacology. 2006 May;31(5):904-11 [16160705] Pediatrics. 2006 Nov;118(5):e1328-35 [17079534] Arch Dis Child Fetal Neonatal Ed. 2007 Jan;92(1):F30-3 [16769711] Pediatrics. 2007 May;119(5):876-90 [17473087] Pediatrics. 2007 Jul;120(1):40-8 [17606560] Pediatrics. 2008 Jan;121(1):73-81 [18166559] J Neurosci. 2000 Oct 1;20(19):7424-9 [11007901] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1542/peds.2008-1928 ER - TY - JOUR T1 - Polychlorinated biphenyls and risk of testicular germ cell tumors. AN - 66978883; 19223531 AB - Exposure to endocrine-disrupting chemicals, such as polychlorinated biphenyls (PCB), may alter hormonal balance and thereby increase risk of testicular germ cell tumors (TGCT). To study the relationship of PCBs to TGCT, prediagnostic serum samples from 736 cases and 913 controls in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants study were analyzed. Adjusted odds ratios and 95% confidence intervals were estimated using logistic regression. PCB levels were examined in association with all TGCT and, separately, with each histologic type (seminoma and nonseminoma). Risks associated with seven functional groupings of PCBs, as well as sum of PCBs, were also examined. There were significantly decreased risks of TGCT in association with eight PCBs (PCB-118, PCB-138, PCB-153, PCB-156, PCB-163, PCB-170, PCB-180, and PCB-187) and no association with the remaining three (PCB-99, PCB-101, and PCB-183). The same eight congeners were significantly associated with decreased risk of nonseminoma, whereas five (PCB-138, PCB-153, PCB-156, PCB-163, and PCB-170) were associated with decreased risk of seminoma. All functional groupings of PCBs were also associated with decreased risk of TGCT and of nonseminoma, whereas six of the seven functional groups were associated with decreased risk of seminoma. Sum of PCBs was significantly associated with decreased risk of TGCT (P(trend) = 0.006), nonseminoma (P(trend) = 0.007), and seminoma (P(trend) = 0.05). Overall, these data do not support the hypothesis that PCB exposure increases the risk of TGCT. JF - Cancer research AU - McGlynn, Katherine A AU - Quraishi, Sabah M AU - Graubard, Barry I AU - Weber, Jean-Philippe AU - Rubertone, Mark V AU - Erickson, Ralph L AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA. mcglynnk@mail.nih.gov Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 SP - 1901 EP - 1909 VL - 69 IS - 5 KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Risk KW - Hypospadias -- chemically induced KW - Age Factors KW - Humans KW - Adult KW - Middle Aged KW - Dichlorodiphenyl Dichloroethylene -- toxicity KW - Adolescent KW - Male KW - Polychlorinated Biphenyls -- toxicity KW - Testicular Neoplasms -- chemically induced KW - Neoplasms, Germ Cell and Embryonal -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66978883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Polychlorinated+biphenyls+and+risk+of+testicular+germ+cell+tumors.&rft.au=McGlynn%2C+Katherine+A%3BQuraishi%2C+Sabah+M%3BGraubard%2C+Barry+I%3BWeber%2C+Jean-Philippe%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2009-03-01&rft.volume=69&rft.issue=5&rft.spage=1901&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-3935 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-20 N1 - Date created - 2009-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Horm Res. 1999 Dec;51(6):261-9 [10640886] World J Urol. 2004 Apr;22(1):2-14 [15034740] Hum Reprod. 2001 May;16(5):972-8 [11331648] Cancer Invest. 2001;19(8):842-53 [11768038] Eur J Endocrinol. 2002 Mar;146(3):357-63 [11888842] Hum Reprod. 2002 Aug;17(8):1973-9 [12151423] Am J Public Health. 2002 Dec;92(12):1900-4 [12453804] Fertil Steril. 2002 Dec;78(6):1187-94 [12477510] Cancer. 2003 Jan 1;97(1):63-70 [12491506] Environ Health Perspect. 2003 Apr;111(4):409-13 [12676591] APMIS. 2003 Jan;111(1):267-78; discussion 278-9 [12752272] Environ Health Perspect. 2003 Jun;111(7):930-4 [12782494] Environ Health Perspect. 2003 Sep;111(12):1505-11 [12948891] Arch Toxicol. 2004 May;78(5):252-68 [15064922] Hum Reprod. 2004 Sep;19(9):2066-75 [15284211] Nature. 1969 Oct 18;224(5216):247-50 [5388040] Arch Environ Contam Toxicol. 1986 Jul;15(4):333-41 [3090950] Int J Androl. 1987 Feb;10(1):19-28 [3034791] IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;6:1-729 [3504843] Environ Health Perspect. 1989 May;81:225-39 [2503374] Zentralbl Gynakol. 1990;112(13):817-21 [1700563] Nature. 1995 Jun 15;375(6532):581-5 [7791873] Int J Cancer. 1996 Mar 15;65(6):723-9 [8631581] Environ Health Perspect. 1996 Aug;104 Suppl 4:741-803 [8880001] Environ Health Perspect. 1997 Jan;105(1):13-4 [9074863] Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2224-36 [16172236] Pharmacogenet Genomics. 2006 May;16(5):375-7 [16609370] Nat Clin Pract Urol. 2006 Oct;3(10):532-43 [17031378] J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):184-6 [17049842] J Assist Reprod Genet. 2006 Sep-Oct;23(9-10):393-9 [17019632] Environ Health Perspect. 2007 Oct;115(10):1490-6 [17938741] Environ Health Perspect. 2008 Mar;116(3):269-77 [18335090] J Natl Cancer Inst. 2008 May 7;100(9):663-71 [18445826] Arch Environ Contam Toxicol. 2008 Jul;55(1):143-52 [18166985] Eur J Pediatr Surg. 2000 Oct;10(5):304-9 [11194541] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-3935 ER - TY - JOUR T1 - V-PROLI/NO, a nitric oxide donor prodrug, protects liver cells from arsenic-induced toxicity. AN - 66973476; 19154403 AB - Inorganic arsenic shows great promise in human cancer chemotherapy, although hepatotoxicity is a major limiting side-effect. O(2)-Vinyl 1-[2-(Carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (V-PROLI/NO) [Correction added after publication 19 December 2008: 1-[2-(Carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (V-PROLI/NO) was corrected to O(2)-Vinyl 1-[2-(Carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (V-PROLI/NO)] is a nitric oxide (NO) donor prodrug that is metabolized by liver cytochromes P450 to release NO. Other NO-releasing agents have been shown to mitigate arsenic toxicity. Thus, the effects of V-PROLI/NO pretreatment on the toxicity of inorganic arsenic (as NaAsO(2)) were studied in vitro in a human liver (HepG2) cell line. HepG2 cells acted upon the prodrug to release NO, as assessed by nitrite levels, in a dose- and time-dependent fashion to maximal levels of 57-fold above control levels. In cells pretreated with V-PROLI/NO (200 microM, 24 h) then exposed to arsenic for an additional 24 h, arsenic was much less toxic (LC(50) = 151.9 +/- 5.9 microM) than in control cells (LC(50) = 90.5 +/- 6.5 microM) and the reduced cytolethality was directly related to the level of NO produced. V-PROLI/NO also increased CYP2E1 transcriptional expression in a dose-dependent manner and CYP2E1 expression was directly related to the level of NO produced and the reduction in arsenic cytotoxicity. V-PROLI/NO pretreatment markedly reduced arsenic-induced apoptosis as measured by DNA fragmentation. Pretreatment with V-PROLI/NO suppressed phosphorylation of JNK1/2 after arsenic exposure. Arsenic increased metallothionein, a metal-binding protein important in arsenic tolerance, and V-PROLI/NO pretreatment caused additional increases in metallothionein levels. Thus, the prodrug, V-PROLI/NO, protects against arsenic toxicity in cultured human liver cells, reducing cytolethality, apoptosis and dysregulation of mitogen-activated protein kinases, through generation of NO formed after metabolism by liver cell enzymes, possibly including CYP2E1. JF - Cancer science AU - Qu, Wei AU - Liu, Jie AU - Dill, Anna L AU - Saavedra, Joseph E AU - Keefer, Larry K AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 382 EP - 388 VL - 100 IS - 3 KW - Arsenicals KW - 0 KW - Nitric Oxide Donors KW - Prodrugs KW - Nitric Oxide KW - 31C4KY9ESH KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Gene Expression -- drug effects KW - Blotting, Western KW - Humans KW - Apoptosis -- drug effects KW - Nitric Oxide -- metabolism KW - DNA Fragmentation -- drug effects KW - Cytochrome P-450 CYP2E1 -- drug effects KW - JNK Mitogen-Activated Protein Kinases -- drug effects KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Nitric Oxide Donors -- pharmacology KW - Hepatocytes -- drug effects KW - Prodrugs -- pharmacology KW - Arsenicals -- adverse effects KW - Prodrugs -- metabolism KW - Nitric Oxide Donors -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66973476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+science&rft.atitle=V-PROLI%2FNO%2C+a+nitric+oxide+donor+prodrug%2C+protects+liver+cells+from+arsenic-induced+toxicity.&rft.au=Qu%2C+Wei%3BLiu%2C+Jie%3BDill%2C+Anna+L%3BSaavedra%2C+Joseph+E%3BKeefer%2C+Larry+K%3BWaalkes%2C+Michael+P&rft.aulast=Qu&rft.aufirst=Wei&rft.date=2009-03-01&rft.volume=100&rft.issue=3&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=Cancer+science&rft.issn=1349-7006&rft_id=info:doi/10.1111%2Fj.1349-7006.2008.01050.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-25 N1 - Date created - 2009-03-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2000 Jun;55(2):460-7 [10828279] Blood. 1996 Aug 1;88(3):1052-61 [8704214] Biol Trace Elem Res. 2000 Winter;78(1-3):241-54 [11314982] Toxicol Lett. 2001 Feb 28;119(2):103-8 [11311571] Carcinogenesis. 2002 Jan;23(1):151-9 [11756236] Annu Rev Pharmacol Toxicol. 2003;43:585-607 [12415121] Hepatology. 2003 Feb;37(2):324-33 [12540782] Chem Res Toxicol. 2003 Jul;16(7):873-80 [12870890] J Pharmacol Exp Ther. 2004 Jul;310(1):18-24 [15010501] Toxicol Appl Pharmacol. 1982 Oct;66(1):134-42 [7157381] Fundam Appl Toxicol. 1993 Feb;20(2):184-9 [8449390] J Med Chem. 1996 Oct 25;39(22):4361-5 [8893830] J Surg Res. 1997 Jan;67(1):26-32 [9070177] Blood. 1997 May 1;89(9):3354-60 [9129042] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] Anesthesiology. 1998 Jan;88(1):190-5 [9447872] Am J Physiol. 1998 Sep;275(3 Pt 1):L551-8 [9728050] Biochem Mol Biol Int. 1998 Sep;45(6):1121-7 [9762410] J Biol Chem. 1998 Dec 4;273(49):33027-34 [9830056] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Cancer Res. 1999 Jul 1;59(13):3053-8 [10397243] Nitric Oxide. 2005 Mar;12(2):114-20 [15740985] J Clin Oncol. 2005 Apr 1;23(10):2396-410 [15800332] J Pharm Sci. 2006 Jan;95(1):108-15 [16315224] Leukemia. 2006 May;20(5):881-3 [16525498] Nitric Oxide. 2006 Jun;14(4):309-15 [16545970] J Am Chem Soc. 2006 Sep 27;128(38):12473-83 [16984198] J Natl Cancer Inst. 2007 May 2;99(9):667-8 [17470732] Environ Health Perspect. 2007 Jul;115(7):1101-6 [17637929] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] Acta Pharmacol Sin. 2007 Sep;28(9):1429-33 [17723176] Cancer Lett. 2007 Oct 28;256(2):238-45 [17658681] Blood. 2008 Mar 1;111(5):2505-15 [18299451] Pediatr Blood Cancer. 2008 Jun;50(6):1265-7 [18300308] Toxicol Sci. 2008 Sep;105(1):24-32 [18566022] Science. 1995 Nov 24;270(5240):1326-31 [7481820] J Biol Chem. 1996 Jun 28;271(26):15703-7 [8663189] Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14382-7 [11121042] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1349-7006.2008.01050.x ER - TY - JOUR T1 - EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. AN - 66970635; 19150350 AB - Cancer progression/metastases and embryonic development share many properties including cellular plasticity, dynamic cell motility, and integral interaction with the microenvironment. We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence of hepatic cancer cells with stem/progenitor features. Gene expression profiling and immunohistochemistry analyses were used to analyze 235 tumor specimens derived from 2 recently identified HCC subtypes (EpCAM(+) alpha-fetoprotein [AFP(+)] HCC and EpCAM(-) AFP(-) HCC). These subtypes differed in their expression of AFP, a molecule produced in the developing embryo, and EpCAM, a cell surface hepatic stem cell marker. Fluorescence-activated cell sorting was used to isolate EpCAM(+) HCC cells, which were tested for hepatic stem/progenitor cell properties. Gene expression and pathway analyses revealed that the EpCAM(+) AFP(+) HCC subtype had features of hepatic stem/progenitor cells. Indeed, the fluorescence-activated cell sorting-isolated EpCAM(+) HCC cells displayed hepatic cancer stem cell-like traits including the abilities to self-renew and differentiate. Moreover, these cells were capable of initiating highly invasive HCC in nonobese diabetic, severe combined immunodeficient mice. Activation of Wnt/beta-catenin signaling enriched the EpCAM(+) cell population, whereas RNA interference-based blockage of EpCAM, a Wnt/beta-catenin signaling target, attenuated the activities of these cells. Taken together, our results suggest that HCC growth and invasiveness is dictated by a subset of EpCAM(+) cells, opening a new avenue for HCC cancer cell eradication by targeting Wnt/beta-catenin signaling components such as EpCAM. JF - Gastroenterology AU - Yamashita, Taro AU - Ji, Junfang AU - Budhu, Anuradha AU - Forgues, Marshonna AU - Yang, Wen AU - Wang, Hong-Yang AU - Jia, Huliang AU - Ye, Qinghai AU - Qin, Lun-Xiu AU - Wauthier, Elaine AU - Reid, Lola M AU - Minato, Hiroshi AU - Honda, Masao AU - Kaneko, Shuichi AU - Tang, Zhao-You AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 1012 EP - 1024 VL - 136 IS - 3 KW - Antigens, Neoplasm KW - 0 KW - Cell Adhesion Molecules KW - EPCAM protein, human KW - Epithelial Cell Adhesion Molecule KW - RNA, Small Interfering KW - Glycogen Synthase Kinase 3 beta KW - EC 2.7.11.1 KW - Glycogen Synthase Kinase 3 KW - EC 2.7.11.26 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Humans KW - Mice, Inbred NOD KW - Prognosis KW - Stem Cells -- pathology KW - Cell Line, Tumor KW - Mice KW - Stem Cells -- physiology KW - Cell Separation KW - Neoplasm Transplantation KW - Gene Expression Regulation, Neoplastic KW - Signal Transduction -- physiology KW - Tumor Cells, Cultured KW - Glycogen Synthase Kinase 3 -- metabolism KW - Mice, SCID KW - Glycogen Synthase Kinase 3 -- antagonists & inhibitors KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Cell Adhesion Molecules -- genetics KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- pathology KW - Cell Adhesion Molecules -- metabolism KW - Antigens, Neoplasm -- metabolism KW - Liver Neoplasms -- physiopathology KW - Carcinoma, Hepatocellular -- physiopathology KW - Antigens, Neoplasm -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66970635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=EpCAM-positive+hepatocellular+carcinoma+cells+are+tumor-initiating+cells+with+stem%2Fprogenitor+cell+features.&rft.au=Yamashita%2C+Taro%3BJi%2C+Junfang%3BBudhu%2C+Anuradha%3BForgues%2C+Marshonna%3BYang%2C+Wen%3BWang%2C+Hong-Yang%3BJia%2C+Huliang%3BYe%2C+Qinghai%3BQin%2C+Lun-Xiu%3BWauthier%2C+Elaine%3BReid%2C+Lola+M%3BMinato%2C+Hiroshi%3BHonda%2C+Masao%3BKaneko%2C+Shuichi%3BTang%2C+Zhao-You%3BWang%2C+Xin+Wei&rft.aulast=Yamashita&rft.aufirst=Taro&rft.date=2009-03-01&rft.volume=136&rft.issue=3&rft.spage=1012&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/10.1053%2Fj.gastro.2008.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-07 N1 - Date created - 2009-02-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2006 Feb 15;66(4):1883-90; discussion 1895-6 [16488983] Nat Med. 2003 Apr;9(4):416-23 [12640447] Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9912-7 [16782807] Stem Cells. 2006 Aug;24(8):1852-8 [16627685] Cancer Cell. 2006 Aug;10(2):99-111 [16904609] N Engl J Med. 2006 Sep 21;355(12):1253-61 [16990388] Cancer Res. 2006 Oct 1;66(19):9339-44 [16990346] Nature. 2006 Dec 7;444(7120):761-5 [17151667] Nature. 2007 Jan 4;445(7123):111-5 [17122771] Nature. 2007 Jan 4;445(7123):106-10 [17122772] Br J Cancer. 2007 Apr 10;96(7):1013-9 [17325709] Genes Dev. 2003 May 15;17(10):1253-70 [12756227] Stem Cells. 2003;21(4):506-8 [12832703] Nat Med. 2004 Jan;10(1):55-63 [14702635] Oncogene. 2004 Jul 29;23(34):5748-58 [15195135] Biochim Biophys Acta. 1976 Oct 12;458(3):283-321 [1067873] Br J Cancer. 1978 Jul;38(1):1-23 [356869] Cancer Res. 1984 Jun;44(6):2259-65 [6372991] Am J Physiol. 1992 Aug;263(2 Pt 1):G139-48 [1325126] Lab Invest. 1994 Jan;70(1):6-22 [8302019] Environ Health Perspect. 1993 Dec;101 Suppl 5:15-26 [7516873] Nat Med. 1997 Jul;3(7):730-7 [9212098] Blood. 1997 Dec 15;90(12):5002-12 [9389720] Nature. 2004 Nov 18;432(7015):396-401 [15549107] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Nat Rev Cancer. 2005 Apr;5(4):275-84 [15803154] Nature. 2005 Apr 14;434(7035):843-50 [15829953] Cancer Res. 2005 Oct 15;65(20):9328-37 [16230395] Hepatology. 2006 Feb;43(2 Suppl 1):S89-98 [16447292] Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63 [17548814] Gastroenterology. 2007 Jun;132(7):2542-56 [17570225] Am J Pathol. 2007 Aug;171(2):386-95 [17600130] J Exp Med. 2007 Aug 6;204(8):1973-87 [17664288] Cancer Res. 2007 Oct 1;67(19):8980-4 [17908997] J Natl Cancer Inst. 2007 Oct 3;99(19):1435-40 [17895479] Mol Biol Cell. 2007 Nov;18(11):4292-303 [17761539] Cancer Res. 2007 Nov 15;67(22):10831-9 [18006828] Cell. 2007 Nov 30;131(5):861-72 [18035408] Nature. 2007 Dec 20;450(7173):1235-9 [18097410] Cancer Cell. 2008 Feb;13(2):153-66 [18242515] Cancer Res. 2008 Mar 1;68(5):1451-61 [18316609] J Clin Invest. 2008 Jun;118(6):2111-20 [18497886] J Mol Med (Berl). 1999 Oct;77(10):699-712 [10606205] Cell. 2000 Jan 7;100(1):57-70 [10647931] Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12132-7 [11050242] Nat Rev Genet. 2002 Jul;3(7):499-512 [12094228] Nat Genet. 2002 Aug;31(4):339-46 [12149612] FASEB J. 2002 Oct;16(12):1665-7 [12207007] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218] Nat Med. 2006 Apr;12(4):410-6 [16532004] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1053/j.gastro.2008.12.004 ER - TY - JOUR T1 - S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling. AN - 66966187; 18988672 AB - S-glutathionylation is a physiological, reversible protein modification of cysteine residues with glutathione in response to mild oxidative stress. Because the key cell growth regulator signal transducer and activator of transcription (STAT) 3 is particularly susceptible to redox regulation, we hypothesized that oxidative modification of cysteine residues of STAT3 by S-glutathionylation may occur. Herein, we show that the cysteine residues of STAT3 are modified by a thiol-alkylating agent and are the targets of S-glutathionylation. STAT3 protein thiol reactivity was reversibly attenuated with concomitant increase in the S-glutathionylation of STAT3 upon treatment of human HepG2 hepatoma cells with pyrrolidine dithiocarbamate, glutathione disulfide, or diamide. Under these conditions there was a marked reduction in IL-6-dependent STAT3 signaling, including decreased STAT3 tyrosine phosphorylation, loss in nuclear accumulation of STAT3, and impaired expression of target genes, such as fibrinogen-gamma. In a cell-free system, diamide induced glutathionylation of STAT3, which was decreased upon addition of glutaredoxin (GRX)-1, a deglutathionylation enzyme, or the reducing agent, dithiothreitol. Glutathionylated STAT3 was a poor Janus protein tyrosine kinase 2 substrate in vitro, and it exhibited low DNA-binding activity. Cellular GRX-1 activity was inhibited by diamide and pyrrolidine dithiocarbamate treatment; however, ectopic expression of GRX-1 was accompanied by a modest increase in phosphorylation, nuclear translocation, and DNA-binding ability of STAT3 in response to IL-6. These results are the first to show S-glutathionylation of STAT3, a modification that may exert regulatory function in STAT3 signaling. JF - Endocrinology AU - Xie, Yi AU - Kole, Sutapa AU - Precht, Patricia AU - Pazin, Michael J AU - Bernier, Michel AD - Laboratories of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 1122 EP - 1131 VL - 150 IS - 3 KW - Antioxidants KW - 0 KW - Diamines KW - GLRX protein, human KW - Glutaredoxins KW - Interleukin-6 KW - Oxidants KW - Pyrrolidines KW - STAT3 Transcription Factor KW - STAT3 protein, human KW - Thiocarbamates KW - pyrrolidine dithiocarbamic acid KW - 25769-03-3 KW - Janus Kinase 2 KW - EC 2.7.10.2 KW - Glutathione KW - GAN16C9B8O KW - Cysteine KW - K848JZ4886 KW - Abridged Index Medicus KW - Index Medicus KW - Cysteine -- metabolism KW - Oxidants -- pharmacology KW - Humans KW - Diamines -- pharmacology KW - Glutaredoxins -- genetics KW - Interleukin-6 -- pharmacology KW - Glutaredoxins -- physiology KW - Signal Transduction -- physiology KW - Antioxidants -- pharmacology KW - Phosphorylation KW - Transfection KW - Cells, Cultured KW - Pyrrolidines -- pharmacology KW - Glutaredoxins -- metabolism KW - Thiocarbamates -- pharmacology KW - Janus Kinase 2 -- metabolism KW - Protein Processing, Post-Translational -- drug effects KW - STAT3 Transcription Factor -- physiology KW - Protein Processing, Post-Translational -- physiology KW - Glutathione -- metabolism KW - STAT3 Transcription Factor -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66966187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=S-glutathionylation+impairs+signal+transducer+and+activator+of+transcription+3+activation+and+signaling.&rft.au=Xie%2C+Yi%3BKole%2C+Sutapa%3BPrecht%2C+Patricia%3BPazin%2C+Michael+J%3BBernier%2C+Michel&rft.aulast=Xie&rft.aufirst=Yi&rft.date=2009-03-01&rft.volume=150&rft.issue=3&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2008-1241 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2009-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Biochem Cell Biol. 2003 Mar;35(3):316-23 [12531244] J Chromatogr A. 2009 Apr 17;1216(16):3533-7 [18602637] J Immunol. 2003 Jul 1;171(1):257-66 [12817006] J Biol Chem. 2003 Dec 12;278(50):50226-33 [14522978] Front Biosci. 2004 Jan 1;9:283-9 [14766366] J Biol Chem. 2004 Feb 27;279(9):7740-50 [14668336] Biochem J. 2004 May 1;379(Pt 3):595-600 [14763903] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6728-33 [15096606] Biochem J. 2004 Aug 1;381(Pt 3):675-83 [15139849] J Biol Chem. 1986 Jan 25;261(3):996-1001 [3944096] Methods Enzymol. 1987;143:264-70 [3657543] J Biol Chem. 2000 Jul 14;275(28):21130-9 [10801793] Eur J Biochem. 2000 Aug;267(16):4928-44 [10931175] Mol Cell Biol. 2001 Mar;21(5):1621-32 [11238899] FEBS Lett. 2001 Apr 20;495(1-2):71-6 [11322950] J Biol Chem. 2001 Jun 15;276(24):21618-26 [11290748] Biochemistry. 2001 Nov 27;40(47):14134-42 [11714266] Sci STKE. 2001 Jun 12;2001(86):pl1 [11752655] Cell. 1993 Jul 30;74(2):237-44 [8343952] J Pathol. 1997 Mar;181(3):257-66 [9155709] Arch Biochem Biophys. 1998 Jul 15;355(2):145-52 [9675020] Biochem J. 1999 Mar 15;338 ( Pt 3):659-65 [10051436] FEBS Lett. 1999 Apr 1;448(1):49-52 [10217408] J Biol Chem. 1999 Jun 18;274(25):17580-6 [10364193] FASEB J. 1999 Sep;13(12):1481-90 [10463938] Mol Cancer. 2005 Jan 12;4(1):2 [15647107] Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):348-66 [15706083] J Biol Chem. 2005 Mar 18;280(11):10846-54 [15653693] Annu Rev Immunol. 2005;23:1-21 [15771564] J Biol Chem. 2005 Jul 8;280(27):25901-6 [15888455] Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):964-72 [15998251] Eur J Cancer. 2005 Nov;41(16):2502-12 [16199153] FASEB J. 2006 Mar;20(3):518-20 [16415107] Biochem Biophys Res Commun. 2006 May 5;343(2):435-42 [16546138] EMBO J. 2006 May 3;25(9):1945-56 [16619030] World J Gastroenterol. 2006 Jun 14;12(22):3512-22 [16773708] Cancer Res. 2006 Jul 1;66(13):6800-6 [16818657] Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13086-91 [16916935] J Biol Chem. 2006 Oct 20;281(42):31369-79 [16926159] Cytokine Growth Factor Rev. 2006 Dec;17(6):451-61 [17045835] Clin Cancer Res. 2006 Dec 1;12(23):7140-8 [17145839] Mol Cancer Ther. 2007 Jan;6(1):112-21 [17237271] Circ Res. 2007 Feb 2;100(2):213-9 [17185628] J Biol Chem. 2007 Apr 27;282(17):12467-74 [17324929] J Biol Chem. 2007 May 11;282(19):14428-36 [17355958] Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6 [17463090] J Biol Chem. 2007 May 18;282(20):14816-26 [17389601] Biochemistry. 2007 Jul 3;46(26):7765-80 [17555331] Curr Opin Pharmacol. 2007 Aug;7(4):381-91 [17662654] Free Radic Biol Med. 2007 Nov 1;43(9):1299-312 [17893043] Oncogene. 2007 Dec 6;26(55):7656-64 [17563747] BMC Biochem. 2007;8:26 [18070357] EMBO J. 2008 Feb 20;27(4):642-53 [18200042] Cancer Lett. 2008 Apr 18;262(2):201-13 [18248786] Cancer Res. 2008 Apr 15;68(8):2870-7 [18413755] Cancer Biol Ther. 2007 Nov;6(11):1733-42 [17986852] Cancer Biol Ther. 2007 Dec;6(12):1900-7 [18059167] J Biol Chem. 2003 Feb 14;278(7):5242-9 [12456685] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2008-1241 ER - TY - JOUR T1 - Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice. AN - 66966104; 18974269 AB - Color vision is mediated by cone photoreceptors that express opsin photopigments with sensitivities to different light wavelengths. Most mammals, including mice, differentially express M and S opsins for response to medium-long and short wavelengths, respectively. Previous studies demonstrated that a thyroid hormone receptor (TRbeta2) is critical for opsin patterning: in TRbeta2-deficient mice, M opsin is lost and all cones instead express S opsin. Here, to investigate the requirement for thyroid hormone in cone development, we studied Tshr(-/-)mice as a model of congenital hypothyroidism. The onset of M opsin expression in Tshr(-/-)mice was severely delayed until after postnatal d 17 (P17), and M opsin expression failed to attain normal levels at older adult ages. S opsin showed a subtler change with an extended distribution pattern over the superior-inferior axis of the retina. Similar opsin abnormalities were detected in wild-type C57BL/6J mice made hypothyroid by methimazole treatment. In Tshr(-/-) mice, T(3) treatment from P8 recovered significant M opsin expression at P17. Tshr(-/-) mice produced normal numbers of cones, indicating that the major requirement for thyroid hormone is in opsin patterning rather than in cone generation. The phenotype is similar to, although milder than, that caused by loss of TRbeta2 and indicates the necessity for thyroid hormone for cone maturation. JF - Endocrinology AU - Lu, Ailing AU - Ng, Lily AU - Ma, Michelle AU - Kefas, Benjamin AU - Davies, Terry F AU - Hernandez, Arturo AU - Chan, Chi-Chao AU - Forrest, Douglas AD - National Institute of Diabetes and Digestive and Kidney Diseases, Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892-1772, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 1536 EP - 1544 VL - 150 IS - 3 KW - Cone Opsins KW - 0 KW - Receptors, Thyrotropin KW - Triiodothyronine KW - 06LU7C9H1V KW - Methimazole KW - 554Z48XN5E KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Triiodothyronine -- pharmacology KW - Retina -- drug effects KW - Mice KW - Models, Biological KW - Mice, Knockout KW - Pregnancy KW - Receptors, Thyrotropin -- genetics KW - Mice, Inbred C57BL KW - Retina -- pathology KW - Time Factors KW - Female KW - Congenital Hypothyroidism -- pathology KW - Cone Opsins -- genetics KW - Retinal Cone Photoreceptor Cells -- pathology KW - Cone Opsins -- metabolism KW - Body Patterning -- drug effects KW - Retinal Cone Photoreceptor Cells -- metabolism KW - Congenital Hypothyroidism -- genetics KW - Congenital Hypothyroidism -- chemically induced KW - Gene Expression Regulation, Developmental -- drug effects KW - Retinal Cone Photoreceptor Cells -- drug effects KW - Body Patterning -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66966104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Retarded+developmental+expression+and+patterning+of+retinal+cone+opsins+in+hypothyroid+mice.&rft.au=Lu%2C+Ailing%3BNg%2C+Lily%3BMa%2C+Michelle%3BKefas%2C+Benjamin%3BDavies%2C+Terry+F%3BHernandez%2C+Arturo%3BChan%2C+Chi-Chao%3BForrest%2C+Douglas&rft.aulast=Lu&rft.aufirst=Ailing&rft.date=2009-03-01&rft.volume=150&rft.issue=3&rft.spage=1536&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2008-1092 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2009-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Thyroid. 1994 Winter;4(4):467-74 [7711512] Invest Ophthalmol Vis Sci. 2008 May;49(5):2039-45 [18436838] Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):589-95 [8570600] Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4743-5 [10220361] Eur J Endocrinol. 2004 Nov;151 Suppl 3:U25-37 [15554884] Pediatr Res. 2005 Jun;57(6):902-7 [15774837] Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2897-904 [16043864] Ophthalmic Res. 2005 Jul-Aug;37(4):225-34 [16006782] J Clin Invest. 2006 Feb;116(2):476-84 [16410833] Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6218-23 [16606843] Vis Neurosci. 2006 Mar-Apr;23(2):169-79 [16638170] Neuron. 1999 Oct;24(2):299-312 [10571225] Neuron. 1999 Dec;24(4):871-8 [10624950] Nat Genet. 2001 Jan;27(1):94-8 [11138006] Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3998-4003 [11274423] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3985-9 [11891331] Endocrinology. 2002 Jun;143(6):2019-24 [12021164] Trends Endocrinol Metab. 2002 Jul;13(5):215-20 [12185668] Ophthalmic Res. 2002 Jul-Aug;34(4):181-91 [12297689] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15776-81 [12432094] Invest Ophthalmol Vis Sci. 2003 Mar;44(3):996-1007 [12601020] Paediatr Drugs. 2003;5(3):141-9 [12608879] J Clin Invest. 2003 Aug;112(4):588-97 [12925699] Exp Eye Res. 2004 Jun;78(6):1143-54 [15109921] Klin Monbl Augenheilkd. 1977 Nov;171(5):731-4 [304503] J Comp Neurol. 1979 Nov 15;188(2):245-62 [500858] J Comp Neurol. 1979 Nov 15;188(2):263-72 [500859] Scand J Clin Lab Invest. 1982 Nov;42(7):585-93 [7156868] J Comp Neurol. 1983 Nov 20;221(1):31-41 [6643744] Dev Med Child Neurol. 1985 Jun;27(3):317-24 [4018426] Nature. 1989 Jun 22;339(6226):593-7 [2733791] Development. 1992 Jan;114(1):39-47 [1576965] J Comp Neurol. 1993 May 22;331(4):564-77 [8509512] Endocr Rev. 1993 Jun;14(3):348-99 [8319599] Mol Vis. 2006;12:915-30 [16917485] EMBO J. 2006 Oct 18;25(20):4943-51 [17006540] Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5590-8 [17122153] Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59 [17315033] Mol Endocrinol. 2007 May;21(5):1108-19 [17341594] Dev Dyn. 2007 May;236(5):1203-12 [17436273] Mol Genet Metab. 2007 Jul;91(3):268-77 [17512233] Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3827-36 [17652758] Vision Res. 2007 Aug;47(17):2314-26 [17655910] Trends Endocrinol Metab. 2008 Mar;19(2):50-6 [18291666] Invest Ophthalmol Vis Sci. 1995 Jun;36(7):1280-9 [7775105] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2008-1092 ER - TY - JOUR T1 - A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex. AN - 66964477; 19129443 AB - A critical function of the human immunodeficiency virus type 1 Nef protein is the downregulation of CD4 from the surfaces of infected cells. Nef is believed to act by linking the cytosolic tail of CD4 to the endocytic machinery, thereby increasing the rate of CD4 internalization. In support of this model, weak binary interactions between CD4, Nef, and the endocytic adaptor complex, AP-2, have been reported. In particular, dileucine and diacidic motifs in the C-terminal flexible loop of Nef have been shown to mediate binding to a combination of the alpha and sigma2 subunits of AP-2. Here, we report the identification of a potential binding site for the Nef diacidic motif on alpha-adaptin. This site comprises two basic residues, lysine-297 and arginine-340, on the alpha-adaptin trunk domain. The mutation of these residues specifically inhibits the ability of Nef to bind AP-2 and downregulate CD4. We also present evidence that the diacidic motif on Nef and the basic patch on alpha-adaptin are both required for the cooperative assembly of a CD4-Nef-AP-2 complex. This cooperativity explains how Nef is able to efficiently downregulate CD4 despite weak binary interactions between components of the tripartite complex. JF - Journal of virology AU - Chaudhuri, Rittik AU - Mattera, Rafael AU - Lindwasser, O Wolf AU - Robinson, Margaret S AU - Bonifacino, Juan S AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Building 18T, Room 101, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 2518 EP - 2530 VL - 83 IS - 6 KW - Adaptor Protein Complex 2 KW - 0 KW - Adaptor Protein Complex alpha Subunits KW - Antigens, CD4 KW - nef Gene Products, Human Immunodeficiency Virus KW - nef protein, Human immunodeficiency virus 1 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Sequence Alignment KW - Protein Interaction Mapping KW - Models, Molecular KW - HeLa Cells KW - Amino Acid Substitution -- genetics KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Binding KW - Mutation, Missense KW - Protein Structure, Quaternary KW - Adaptor Protein Complex alpha Subunits -- genetics KW - Adaptor Protein Complex alpha Subunits -- metabolism KW - HIV-1 -- physiology KW - nef Gene Products, Human Immunodeficiency Virus -- metabolism KW - Protein Interaction Domains and Motifs KW - Antigens, CD4 -- metabolism KW - Adaptor Protein Complex 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66964477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=A+basic+patch+on+alpha-adaptin+is+required+for+binding+of+human+immunodeficiency+virus+type+1+Nef+and+cooperative+assembly+of+a+CD4-Nef-AP-2+complex.&rft.au=Chaudhuri%2C+Rittik%3BMattera%2C+Rafael%3BLindwasser%2C+O+Wolf%3BRobinson%2C+Margaret+S%3BBonifacino%2C+Juan+S&rft.aulast=Chaudhuri&rft.aufirst=Rittik&rft.date=2009-03-01&rft.volume=83&rft.issue=6&rft.spage=2518&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.02227-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2009-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Apr 16;279(16):16657-61 [14985334] Nature. 1987 Nov 19-25;330(6145):266-9 [3118220] Cell. 1988 Oct 21;55(2):301-8 [3262426] Annu Rev Immunol. 1989;7:579-99 [2653377] Cell. 1990 Nov 30;63(5):1061-72 [2257624] Nature. 1991 Apr 11;350(6318):508-11 [2014052] Cell Regul. 1990 Mar;1(4):369-77 [2100204] Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10971-5 [1720558] Virology. 1992 Mar;187(1):46-55 [1736544] Virology. 1992 May;188(1):391-5 [1566581] J Exp Med. 1993 Jun 1;177(6):1561-6 [8098729] Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5549-53 [8516299] J Virol. 1993 Aug;67(8):4639-50 [8043040] Mol Biol Cell. 2005 Sep;16(9):4231-42 [15987739] J Virol. 2006 Feb;80(3):1311-20 [16415008] Mol Biol Cell. 2006 Dec;17(12):5298-308 [17035630] Traffic. 2007 Jan;8(1):61-76 [17140399] Curr Mol Med. 2007 Mar;7(2):171-84 [17346169] J Virol. 2007 Apr;81(8):3877-90 [17267500] Mol Biol Cell. 2007 May;18(5):1887-96 [17360967] Mol Biol Cell. 2007 Sep;18(9):3351-65 [17581864] J Gen Virol. 2007 Nov;88(Pt 11):3133-8 [17947540] J Virol. 2008 Feb;82(3):1166-74 [18032517] J Virol. 2008 Feb;82(3):1249-58 [18057255] J Biol Chem. 2008 Feb 8;283(6):3011-22 [18073204] J Virol. 2008 Aug;82(16):7758-67 [18524831] J Exp Med. 1994 Jan 1;179(1):101-13 [8270859] Cell. 1994 Mar 11;76(5):853-64 [8124721] J Virol. 1994 May;68(5):3092-101 [8151774] J Virol. 1994 Aug;68(8):5156-63 [8035515] Curr Biol. 1999 Jun 17;9(12):622-31 [10375528] Cell. 1999 Jun 11;97(6):805-15 [10380931] Rev Med Virol. 1999 Apr-Jun;9(2):111-20 [10386338] Mol Cell. 2005 May 27;18(5):519-31 [15916959] Proc Natl Acad Sci U S A. 2005 May 31;102(22):7910-5 [15911768] J Virol. 2005 Sep;79(17):11422-33 [16103193] J Immunol. 2005 Sep 1;175(5):3157-64 [16116206] Curr Top Microbiol Immunol. 2006;303:97-120 [16570858] Microbiol Mol Biol Rev. 2006 Jun;70(2):548-63 [16760313] Retrovirology. 2008;5:84 [18808677] Nature. 2008 Dec 18;456(7224):976-79 [19140243] Virology. 1994 Dec;205(2):578-82 [7975260] J Virol. 1995 Jul;69(7):4112-21 [7769669] EMBO J. 1995 Jun 1;14(11):2424-35 [7781597] Science. 1995 Sep 29;269(5232):1872-5 [7569928] J Cell Sci. 1995 Aug;108 ( Pt 8):2865-75 [7593326] J Cell Biol. 1995 Nov;131(3):619-30 [7593184] EMBO J. 1995 Oct 16;14(20):4961-75 [7588625] EMBO J. 1995 Dec 1;14(23):5869-83 [8846780] Virology. 1996 Mar 1;217(1):293-300 [8599214] Virology. 1996 Mar 1;217(1):397-403 [8599229] Biochemistry. 1996 Aug 13;35(32):10256-61 [8756680] EMBO J. 1997 Dec 1;16(23):6964-76 [9384576] Science. 1998 Apr 17;280(5362):431-4 [9545220] Cell. 1998 Jul 24;94(2):205-16 [9695949] Trends Cell Biol. 1998 Aug;8(8):302-5 [9704405] Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11229-34 [9736718] Science. 1998 Nov 13;282(5392):1327-32 [9812899] Curr Biol. 1998 Nov 5;8(22):1235-8 [9811606] Curr Biol. 1998 Nov 5;8(22):1239-42 [9811611] J Virol. 1999 Mar;73(3):1964-73 [9971776] Mol Biol Cell. 1999 Mar;10(3):677-91 [10069811] Mol Cell Biol. 1999 Apr;19(4):3136-44 [10082580] Cell. 1999 Apr 2;97(1):63-73 [10199403] Curr Biol. 1999 Jun 17;9(12):613-21 [10375525] J Virol. 2000 Jun;74(11):5310-9 [10799608] J Virol. 2000 Jun;74(12):5691-701 [10823877] Protein Sci. 2000 Jun;9(6):1137-48 [10892807] J Biol Chem. 2000 Jul 28;275(30):23097-105 [10807905] J Virol. 2001 Apr;75(8):3960-4 [11264384] J Virol. 2001 Nov;75(21):10113-7 [11581379] Cell. 2002 May 17;109(4):523-35 [12086608] J Virol. 2003 Feb;77(3):2124-33 [12525647] J Virol. 2003 Jul;77(14):8116-26 [12829850] J Cell Biol. 2003 Sep 1;162(5):909-18 [12952941] J Gen Virol. 2003 Oct;84(Pt 10):2705-13 [13679604] Science. 2003 Sep 19;301(5640):1725-8 [14500983] Annu Rev Biochem. 2003;72:395-447 [12651740] J Cell Biol. 2003 Dec 22;163(6):1281-90 [14691137] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.02227-08 ER - TY - JOUR T1 - The chromodomain of Tf1 integrase promotes binding to cDNA and mediates target site selection. AN - 66958500; 19109383 AB - The long terminal repeat (LTR) retrotransposon Tf1 of Schizosaccharomyces pombe integrates specifically into the promoters of pol II-transcribed genes. Its integrase (IN) contains a C-terminal chromodomain related to the chromodomains that bind to the N-terminal tail of histone H3. Although we have been unable to detect an interaction between histone tails and the chromodomain of Tf1 IN, it is possible that the chromodomain plays a role in directing IN to its target sites. To test this idea, we generated transposons with single amino acid substitutions in highly conserved residues of the chromodomain and created a chromodomain-deleted mutant. The mutations, V1290A, Y1292A, W1305A, and CHDDelta, substantially reduced transposition activity in vivo. Blotting assays showed that there was little or no reduction in the levels of IN or cDNA. By measuring the homologous recombination between cDNA and the plasmid copy of Tf1, we found that two of the mutations did not reduce the import of cDNA into the nucleus, while another caused a 33% reduction. Chromatin immunoprecipitation assays revealed that CHDDelta caused an approximately threefold reduction in the binding of IN to the downstream LTR of the cDNA. These data indicate that the chromodomain contributed directly to integration. We therefore tested whether the chromodomain contributed to selecting insertion sites. Results of a target plasmid assay showed that the deletion of the chromodomain resulted in a drastic reduction in the preference for pol II promoters. Collectively, these data indicate that the chromodomain promotes binding of cDNA and plays a key role in efficient targeting. JF - Journal of virology AU - Chatterjee, Atreyi Ghatak AU - Leem, Young Eun AU - Kelly, Felice D AU - Levin, Henry L AD - Section on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 2675 EP - 2685 VL - 83 IS - 6 KW - DNA, Complementary KW - 0 KW - Retroelements KW - Integrases KW - EC 2.7.7.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Sequence Alignment KW - Amino Acid Substitution -- genetics KW - Molecular Sequence Data KW - Chromatin Immunoprecipitation KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Sequence Deletion KW - Schizosaccharomyces -- genetics KW - Integrases -- metabolism KW - Integrases -- genetics KW - DNA, Complementary -- metabolism KW - Recombination, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66958500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=The+chromodomain+of+Tf1+integrase+promotes+binding+to+cDNA+and+mediates+target+site+selection.&rft.au=Chatterjee%2C+Atreyi+Ghatak%3BLeem%2C+Young+Eun%3BKelly%2C+Felice+D%3BLevin%2C+Henry+L&rft.aulast=Chatterjee&rft.aufirst=Atreyi&rft.date=2009-03-01&rft.volume=83&rft.issue=6&rft.spage=2675&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.01588-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2009-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3936-41 [10737770] Nucleic Acids Res. 2000 Dec 1;28(23):4709-16 [11095681] EMBO J. 2001 Feb 15;20(4):924-32 [11179236] Science. 2001 Apr 6;292(5514):110-3 [11283354] Gene. 2001 Sep 5;275(1):19-29 [11574148] Nature. 2002 Mar 7;416(6876):103-7 [11882902] Science. 2002 Mar 15;295(5562):2080-3 [11859155] Cell. 2002 Aug 23;110(4):521-9 [12202041] Eukaryot Cell. 2002 Feb;1(1):44-55 [12455970] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5891-5 [12730380] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5586-8 [12732725] Genome Res. 2003 Sep;13(9):1984-97 [12952871] Science. 2003 Oct 17;302(5644):415-9 [14564000] PLoS Biol. 2004 Aug;2(8):E234 [15314653] J Virol. 1978 Oct;28(1):279-91 [81316] J Virol. 1980 Oct;36(1):115-9 [6160262] J Biol Chem. 1985 Jul 15;260(14):8243-9 [2989284] Proc Natl Acad Sci U S A. 1987 Oct;84(20):7041-5 [2823251] J Virol. 1990 Jun;64(6):2599-607 [2159534] J Virol. 1993 Jan;67(1):19-28 [7677953] EMBO J. 1993 Dec;12(12):4885-95 [8223497] Mol Microbiol. 1994 Oct;14(1):131-9 [7830551] Mol Cell Biol. 1995 Jun;15(6):3310-7 [7760826] J Virol. 1999 Jun;73(6):5186-90 [10233986] Gene. 2005 Mar 14;347(2):161-73 [15777633] J Virol. 2005 Jun;79(11):6610-9 [15890899] J Virol. 2005 Aug;79(15):9540-55 [16014916] Retrovirology. 2005;2:50 [16092962] J Virol. 2005 Dec;79(23):14863-75 [16282486] J Biol Chem. 2005 Nov 25;280(47):39086-94 [16188891] Nat Med. 2005 Dec;11(12):1287-9 [16311605] Yeast. 2006 Feb;23(3):173-83 [16498704] Eukaryot Cell. 2006 Oct;5(10):1760-9 [17031000] Yeast. 2006 Oct 15;23(13):929-35 [17072884] Genes Dev. 2007 Jul 15;21(14):1767-78 [17639082] Genetics. 2007 Dec;177(4):2519-23 [17947404] Genome Res. 2008 Mar;18(3):359-69 [18256242] Mol Cell. 2008 Apr 11;30(1):98-107 [18406330] J Biol Chem. 2008 Jun 6;283(23):15965-74 [18397885] Mol Cell Biol. 1996 Oct;16(10):5645-54 [8816477] J Virol. 1998 Feb;72(2):1324-33 [9445033] J Bacteriol. 1998 Jun;180(12):3039-48 [9620951] Cell. 1998 Jun 26;93(7):1087-9 [9657139] J Virol. 1998 Nov;72(11):9318-22 [9765482] J Virol. 1999 Mar;73(3):2126-35 [9971795] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.01588-08 ER - TY - JOUR T1 - Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons. AN - 66957705; 18948403 AB - Kisspeptins, the natural ligands of the G-protein-coupled receptor (GPR)-54, are the most potent stimulators of GnRH-1 secretion and as such are critical to reproductive function. However, the mechanism by which kisspeptins enhance calcium-regulated neuropeptide secretion is not clear. In the present study, we used GnRH-1 neurons maintained in mice nasal explants to examine the expression and signaling of GPR54. Under basal conditions, GnRH-1 cells exhibited spontaneous baseline oscillations in intracellular calcium concentration ([Ca(2+)](i)), which were critically dependent on the operation of voltage-gated, tetrodotoxin (TTX)-sensitive sodium channels and were not coupled to calcium release from intracellular pools. Activation of native GPR54 by kisspeptin-10 initiated [Ca(2+)](i) oscillations in quiescent GnRH-1 cells, increased the frequency of calcium spiking in oscillating cells that led to summation of individual spikes into plateau-bursting type of calcium signals in a subset of active cells. These changes predominantly reflected the stimulatory effect of GPR54 activation on the plasma membrane oscillator activity via coupling of this receptor to phospholipase C signaling pathways. Both components of this pathway, inositol 1,3,4-trisphosphate and protein kinase C, contributed to the receptor-mediated modulation of baseline [Ca(2+)](i) oscillations. TTX and 2-aminoethyl diphenylborinate together abolished agonist-induced elevation in [Ca(2+)](i) in almost all cells, whereas flufenamic acid was less effective. Together these results indicate that a plasma membrane calcium oscillator is spontaneously operative in the majority of prenatal GnRH-1 neurons and is facilitated by kisspeptin-10 through phosphatidyl inositol diphosphate hydrolysis and depolarization of neurons by activating TTX-sensitive sodium channels and nonselective cationic channels. JF - Endocrinology AU - Constantin, Stephanie AU - Caligioni, Claudia Simone AU - Stojilkovic, Stanko AU - Wray, Susan AD - Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorder and Stroke/National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 1400 EP - 1412 VL - 150 IS - 3 KW - KISS1 protein, human KW - 0 KW - Kiss1r protein, mouse KW - Kisspeptins KW - Oligopeptides KW - Phosphatidylinositol Phosphates KW - Receptors, G-Protein-Coupled KW - Sodium Channel Blockers KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Tetrodotoxin KW - 4368-28-9 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Phosphatidylinositol Phosphates -- metabolism KW - Mice KW - Receptors, G-Protein-Coupled -- physiology KW - Pregnancy KW - Cells, Cultured KW - Sodium Channel Blockers -- pharmacology KW - Receptors, G-Protein-Coupled -- metabolism KW - Signal Transduction -- genetics KW - Receptors, G-Protein-Coupled -- genetics KW - Embryonic Development -- drug effects KW - Tetrodotoxin -- pharmacology KW - Embryo, Mammalian KW - Female KW - Gene Expression Regulation, Developmental KW - Embryonic Development -- genetics KW - Gonadotropin-Releasing Hormone -- metabolism KW - Calcium Signaling -- drug effects KW - Neurons -- metabolism KW - Cell Membrane -- drug effects KW - Neurons -- drug effects KW - Neurons -- physiology KW - Oligopeptides -- pharmacology KW - Cell Membrane -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66957705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Kisspeptin-10+facilitates+a+plasma+membrane-driven+calcium+oscillator+in+gonadotropin-releasing+hormone-1+neurons.&rft.au=Constantin%2C+Stephanie%3BCaligioni%2C+Claudia+Simone%3BStojilkovic%2C+Stanko%3BWray%2C+Susan&rft.aulast=Constantin&rft.aufirst=Stephanie&rft.date=2009-03-01&rft.volume=150&rft.issue=3&rft.spage=1400&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2008-0979 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2009-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroendocrinology. 2000 Feb;71(2):138-44 [10686527] Endocrinology. 2008 Aug;149(8):3926-32 [18450966] Chronobiol Int. 2000 Jul;17(4):453-69 [10908123] J Neuroendocrinol. 2000 Sep;12(9):919-26 [10971817] Endocrinology. 2008 Sep;149(9):4605-14 [18483150] J Reprod Fertil. 2000 Nov;120(2):391-6 [11058455] Endocrinology. 2000 Dec;141(12):4486-95 [11108259] J Neurosci. 2000 Dec 15;20(24):9290-7 [11125008] J Biol Chem. 2001 Aug 3;276(31):28969-75 [11387329] J Biol Chem. 2001 Sep 14;276(37):34631-6 [11457843] Eur J Neurosci. 2001 Nov;14(10):1613-22 [11860456] Endocrinology. 2002 Apr;143(4):1459-66 [11897704] J Biol Chem. 2002 May 10;277(19):16412-8 [11867632] Endocrinology. 2002 Jul;143(7):2503-7 [12072381] J Neurosci. 2002 Oct 15;22(20):8932-41 [12388600] Mol Endocrinol. 2002 Dec;16(12):2872-91 [12456806] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10972-6 [12944565] N Engl J Med. 2003 Oct 23;349(17):1614-27 [14573733] Biochem Biophys Res Commun. 2003 Dec 26;312(4):1357-63 [14652023] J Neurosci. 2004 May 19;24(20):4737-48 [15152034] Biochem Biophys Res Commun. 2004 Jul 23;320(2):383-8 [15219839] J Neurosci. 2004 Jul 14;24(28):6326-33 [15254088] Endocrinology. 2004 Sep;145(9):4073-7 [15217982] Endocrinology. 2004 Oct;145(10):4565-74 [15242985] Proc Natl Acad Sci U S A. 1989 Oct;86(20):8132-6 [2682637] Endocrinology. 1992 Sep;131(3):1397-402 [1354602] Proc Natl Acad Sci U S A. 1993 May 1;90(9):3908-12 [8387201] Endocrinology. 1993 Nov;133(5):2379-90 [8404690] Arch Histol Cytol. 1993 Oct;56(4):353-70 [8286146] Dev Biol. 1994 Nov;166(1):331-48 [7958456] J Neurophysiol. 1995 Jan;73(1):56-64 [7714589] Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3918-22 [7537379] Cell. 1995 Oct 20;83(2):195-206 [7585937] Dev Biol. 1996 Dec 15;180(2):631-45 [8954733] J Neuroendocrinol. 1997 Sep;9(9):669-75 [9355034] Endocrinology. 1998 Oct;139(10):4037-43 [9751480] Endocrinology. 1999 Mar;140(3):1432-41 [10067872] Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4101-6 [10097170] Mol Endocrinol. 1999 Apr;13(4):587-603 [10194765] Proc Natl Acad Sci U S A. 1999 May 11;96(10):5797-801 [10318964] J Neurosci. 1999 Jul 15;19(14):5898-909 [10407029] Neuroendocrinology. 2004;80(4):264-72 [15665556] Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1761-6 [15665093] J Neuroendocrinol. 2005 Sep;17(9):591-9 [16101898] Endocrinology. 2005 Oct;146(10):4312-20 [15976055] J Neurosci. 2005 Dec 7;25(49):11349-56 [16339030] Biophys J. 2006 Jul 1;91(1):74-83 [16603486] Mol Cell Endocrinol. 2006 Sep 26;257-258:75-83 [16930819] Cell Calcium. 2006 Nov-Dec;40(5-6):495-504 [17030060] Endocrinology. 2007 Jan;148(1):63-71 [17023535] J Neurosci. 2007 Jan 24;27(4):860-7 [17251427] Cell. 2007 Apr 6;129(1):220 [17418797] Endocrinology. 2008 Jan;149(1):279-90 [17916627] Endocrinology. 2008 Mar;149(3):1155-62 [18079199] Endocrinology. 2008 Apr;149(4):1979-86 [18162521] J Neurosci. 2008 Apr 23;28(17):4423-34 [18434521] Endocrinology. 2008 Jul;149(7):3500-11 [18372334] Endocrinology. 2000 May;141(5):1823-38 [10803593] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2008-0979 ER - TY - JOUR T1 - Neonatal exposure to genistein disrupts ability of female mouse reproductive tract to support preimplantation embryo development and implantation. AN - 66951188; 19005167 AB - Female mice treated neonatally with the phytoestrogen genistein (50 mg/kg/day) have multioocyte follicles, lack regular estrous cyclicity, and are infertile even after superovulation. To determine the cause of their infertility, we examined oocyte developmental competence and timing of embryo loss. Eggs obtained by superovulation of genistein-treated or control females were equally capable of being fertilized in vitro and cultured to the blastocyst stage. However, if eggs were fertilized in vivo, retrieved at the pronucleus stage, and cultured, there was a significant reduction in the percentage of embryos from genistein-treated females reaching the blastocyst stage. When these blastocysts were transferred to pseudopregnant recipients, the number of live pups produced was similar to that in controls. Preimplantation embryo development in vivo was examined by flushing embryos from the oviduct and/or uterus. Similar numbers of one-cell and two-cell embryos were obtained from genistein-treated and control females. However, significantly fewer embryos (<50%) were obtained from genistein-treated females on postcoital Days 3 and 4. To determine if neonatal genistein treatment altered the ability of the uterus to support implantation, blastocysts from control donors were transferred to control and genistein-treated pseudopregnant recipients. These experiments demonstrated that genistein-treated females are not capable of supporting normal implantation of control embryos. Taken together, these results suggest that oocytes from mice treated neonatally with genistein are developmentally competent; however, the oviductal environment and the uterus have abnormalities that contribute to the observed reproductive failure. JF - Biology of reproduction AU - Jefferson, Wendy N AU - Padilla-Banks, Elizabeth AU - Goulding, Eugenia H AU - Lao, Shin-Ping C AU - Newbold, Retha R AU - Williams, Carmen J AD - Reproductive Medicine Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 425 EP - 431 VL - 80 IS - 3 SN - 0006-3363, 0006-3363 KW - Phytoestrogens KW - 0 KW - Genistein KW - DH2M523P0H KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Uterus -- physiopathology KW - Ovary -- physiopathology KW - Ovary -- drug effects KW - Disease Models, Animal KW - Embryo Transfer KW - Mice KW - Oocytes -- physiology KW - Uterus -- drug effects KW - Pregnancy KW - Oviducts -- physiopathology KW - Oviducts -- drug effects KW - Cells, Cultured KW - Oocytes -- drug effects KW - Fertilization -- drug effects KW - Female KW - Fertilization -- physiology KW - Embryo Implantation -- physiology KW - Phytoestrogens -- toxicity KW - Genistein -- pharmacology KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Phytoestrogens -- pharmacology KW - Genistein -- toxicity KW - Infertility, Female -- physiopathology KW - Embryonic Development -- drug effects KW - Prenatal Exposure Delayed Effects -- physiopathology KW - Embryonic Development -- physiology KW - Embryo Implantation -- drug effects KW - Infertility, Female -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66951188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+reproduction&rft.atitle=Neonatal+exposure+to+genistein+disrupts+ability+of+female+mouse+reproductive+tract+to+support+preimplantation+embryo+development+and+implantation.&rft.au=Jefferson%2C+Wendy+N%3BPadilla-Banks%2C+Elizabeth%3BGoulding%2C+Eugenia+H%3BLao%2C+Shin-Ping+C%3BNewbold%2C+Retha+R%3BWilliams%2C+Carmen+J&rft.aulast=Jefferson&rft.aufirst=Wendy&rft.date=2009-03-01&rft.volume=80&rft.issue=3&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Biology+of+reproduction&rft.issn=00063363&rft_id=info:doi/10.1095%2Fbiolreprod.108.073171 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-25 N1 - Date created - 2009-02-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lab Anim Sci. 1999 Oct;49(5):530-6 [10551455] Cancer Res. 2001 Jun 1;61(11):4325-8 [11389053] Reprod Toxicol. 2001 Jul-Aug;15(4):399-411 [11489596] JAMA. 2001 Aug 15;286(7):807-14 [11497534] J Endocrinol. 2002 Feb;172(2):221-36 [11834440] Cancer Lett. 2002 Oct 8;184(1):21-7 [12104044] Hum Reprod Update. 2002 Jul-Aug;8(4):323-31 [12206467] Biol Reprod. 2002 Oct;67(4):1268-77 [12297545] Biol Reprod. 2002 Oct;67(4):1285-96 [12297547] Toxicol Sci. 2003 Jan;71(1):74-83 [12520077] Horm Behav. 2003 Aug;44(2):140-5 [13129486] Br J Nutr. 2004 Apr;91(4):607-16 [15035688] Cochrane Database Syst Rev. 2004;(3):CD002125 [15266464] Reprod Toxicol. 2004 Aug-Sep;18(6):803-11 [15279878] Nature. 1967 Mar 4;213(5079):942-3 [6030073] In Vivo. 1991 Jul-Aug;5(4):359-63 [1810421] Hum Reprod. 1994 May;9(5):861-3 [7929732] J Nutr. 1995 Mar;125(3 Suppl):771S-776S [7884563] Lancet. 1997 Jul 5;350(9070):23-7 [9217716] Steroids. 1998 Jan;63(1):14-20 [9437790] Int J Dev Biol. 1998;42(7):879-84 [9853817] Maturitas. 1998 Oct 12;30(2):143-69 [9871909] Am J Obstet Gynecol. 1999 Mar;180(3 Pt 1):737-43 [10076156] Reprod Biol. 2005 Mar;5(1):83-99 [15821780] Biol Reprod. 2005 Oct;73(4):798-806 [15930323] Biol Reprod. 2006 Jan;74(1):161-8 [16192398] Semin Reprod Med. 2006 Jul;24(3):134-41 [16804811] Biol Reprod. 2007 Apr;76(4):611-8 [17182889] Reprod Toxicol. 2007 Apr-May;23(3):308-16 [17250991] PLoS Genet. 2007 Jan 12;3(1):e5 [17222059] Mol Nutr Food Res. 2007 Jul;51(7):832-44 [17604387] Endocrinology. 2007 Aug;148(8):3580-90 [17446182] Reprod Fertil Dev. 2008;20(1):1-8 [18154692] Trends Genet. 2008 Feb;24(2):86-93 [18192063] Environ Health Perspect. 2008 Mar;116(3):416-20 [18335112] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1095/biolreprod.108.073171 ER - TY - JOUR T1 - Characterization of a Coxiella burnetii ftsZ mutant generated by Himar1 transposon mutagenesis. AN - 66934717; 19114492 AB - Coxiella burnetii is a gram-negative obligate intracellular bacterium and the causative agent of human Q fever. The lack of methods to genetically manipulate C. burnetii significantly impedes the study of this organism. We describe here the cloning and characterization of a C. burnetii ftsZ mutant generated by mariner-based Himar1 transposon (Tn) mutagenesis. C. burnetii was coelectroporated with a plasmid encoding the Himar1 C9 transposase variant and a plasmid containing a Himar1 transposon encoding chloramphenicol acetyltransferase, mCherry fluorescent protein, and a ColE1 origin of replication. Vero cells were infected with electroporated C. burnetii and transformants scored as organisms replicating in the presence of chloramphenicol and expressing mCherry. Southern blot analysis revealed multiple transpositions in the C. burnetii genome and rescue cloning identified 30 and 5 insertions in coding and noncoding regions, respectively. Using micromanipulation, a C. burnetii clone was isolated containing a Tn insertion within the C terminus of the cell division gene ftsZ. The ftsZ mutant had a significantly lower growth rate than wild-type bacteria and frequently appeared as filamentous forms displaying incomplete cell division septa. The latter phenotype correlated with a deficiency in generating infectious foci on a per-genome basis compared to wild-type organisms. The mutant FtsZ protein was also unable to bind the essential cell division protein FtsA. This is the first description of C. burnetii harboring a defined gene mutation generated by genetic transformation. JF - Journal of bacteriology AU - Beare, Paul A AU - Howe, Dale AU - Cockrell, Diane C AU - Omsland, Anders AU - Hansen, Bryan AU - Heinzen, Robert A AD - National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 1369 EP - 1381 VL - 191 IS - 5 KW - Bacterial Proteins KW - 0 KW - Cytoskeletal Proteins KW - DNA Transposable Elements KW - FtsZ protein, Bacteria KW - Transposases KW - EC 2.7.7.- KW - Index Medicus KW - Animals KW - Transformation, Bacterial KW - Transposases -- metabolism KW - Electroporation KW - Plasmids -- genetics KW - Humans KW - Amino Acid Sequence KW - Cloning, Molecular KW - Transposases -- genetics KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Vero Cells KW - Microscopy, Electron, Scanning KW - Coxiella burnetii -- pathogenicity KW - Bacterial Proteins -- genetics KW - Bacterial Proteins -- metabolism KW - Coxiella burnetii -- genetics KW - Cytoskeletal Proteins -- chemistry KW - Mutagenesis, Insertional -- methods KW - Bacterial Proteins -- chemistry KW - Coxiella burnetii -- ultrastructure KW - Cytoskeletal Proteins -- metabolism KW - Mutation KW - Coxiella burnetii -- growth & development KW - Cytoskeletal Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66934717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Characterization+of+a+Coxiella+burnetii+ftsZ+mutant+generated+by+Himar1+transposon+mutagenesis.&rft.au=Beare%2C+Paul+A%3BHowe%2C+Dale%3BCockrell%2C+Diane+C%3BOmsland%2C+Anders%3BHansen%2C+Bryan%3BHeinzen%2C+Robert+A&rft.aulast=Beare&rft.aufirst=Paul&rft.date=2009-03-01&rft.volume=191&rft.issue=5&rft.spage=1369&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.01580-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2009-02-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 2000 Jun;182(11):3289-91 [10809714] Science. 2008 Jun 20;320(5883):1651-4 [18566289] Clin Infect Dis. 2001 Aug 1;33(3):312-6 [11438895] Microb Pathog. 2002 Jul;33(1):17-21 [12127796] Infect Immun. 2002 Dec;70(12):6726-33 [12438347] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5455-60 [12704232] Eur J Biochem. 2004 Feb;271(3):494-508 [14728676] Appl Environ Microbiol. 2004 May;70(5):2816-22 [15128537] J Bacteriol. 2004 Nov;186(21):7344-52 [15489446] Mol Microbiol. 2004 Nov;54(3):588-97 [15491352] J Bacteriol. 1981 Nov;148(2):419-25 [6117546] Infect Immun. 1987 Apr;55(4):848-55 [3104207] Infect Immun. 1987 May;55(5):1144-50 [3570458] J Bacteriol. 1988 Mar;170(3):1227-34 [3343219] Ann N Y Acad Sci. 1990;590:491-503 [2198835] Antimicrob Agents Chemother. 1991 Oct;35(10):2070-7 [1759829] J Bacteriol. 1994 Sep;176(17):5233-43 [8071197] Can J Microbiol. 1994 Jul;40(7):583-91 [8076253] Nucleic Acids Res. 1994 Sep 11;22(18):3681-4 [7524026] Infect Immun. 1996 Mar;64(3):796-809 [8641784] J Bacteriol. 1996 May;178(9):2701-8 [8626341] Biochem Cell Biol. 1995 Nov-Dec;73(11-12):915-24 [8722007] RNA. 1996 Sep;2(9):909-18 [8809017] Trends Microbiol. 1996 Sep;4(9):341-2 [8885166] J Bacteriol. 1998 Apr;180(8):2118-24 [9555894] Trends Microbiol. 1999 Apr;7(4):149-54 [10217829] Infect Immun. 1999 Jul;67(7):3308-11 [10377106] Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11428-33 [10500193] Clin Microbiol Rev. 1999 Oct;12(4):518-53 [10515901] Microbiol Immunol. 1999;43(8):743-9 [10524791] J Biol Chem. 2004 Nov 19;279(47):48569-75 [15333635] Infect Immun. 2005 Mar;73(3):1561-7 [15731054] Appl Environ Microbiol. 2005 Apr;71(4):2095-105 [15812043] J Bacteriol. 2005 Jul;187(14):4844-52 [15995199] Mutat Res. 2005 Sep 4;577(1-2):217-27 [16011837] Cell Microbiol. 2006 Mar;8(3):496-507 [16469060] Mol Microbiol. 2006 Sep;61(5):1094-100 [16879409] BMC Biotechnol. 2006;6:42 [17076894] Appl Environ Microbiol. 2007 Jun;73(12):4048-54 [17468273] Appl Environ Microbiol. 2007 Oct;73(20):6644-9 [17720821] J Microbiol Methods. 2008 Mar;72(3):321-5 [18242746] J Bacteriol. 2008 May;190(9):3203-12 [18310349] Curr Opin Cell Biol. 2001 Feb;13(1):55-60 [11163134] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.01580-08 ER - TY - JOUR T1 - Gene-environment interactions and airway disease in children. AN - 66930670; 19221158 AB - Asthma is the most common chronic disease of childhood in the United States, affecting nearly 6.5 million children. The prevalence and severity of childhood asthma have continued to increase over the past 2 decades, despite major advances in the recognition and treatment of this condition. Representing a heterogeneous collection of airway diseases, asthma has multiple pathologic processes resulting from the interactions of genetic susceptibility and environmental exposures. Preventing and treating airway disease in children will require new research approaches to understanding these complex interactions. JF - Pediatrics AU - Schwartz, David A AD - National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. david.schwartz@niehs.nih.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - S151 EP - S159 VL - 123 Suppl 3 KW - Allergens KW - 0 KW - Endotoxins KW - Abridged Index Medicus KW - Index Medicus KW - Genetic Linkage KW - Rural Population KW - Polymorphism, Genetic KW - Humans KW - Endotoxins -- adverse effects KW - Child KW - Allergens -- adverse effects KW - Epigenesis, Genetic KW - Urban Population KW - Asthma -- etiology KW - Genetic Predisposition to Disease KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66930670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Gene-environment+interactions+and+airway+disease+in+children.&rft.au=Schwartz%2C+David+A&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2009-03-01&rft.volume=123+Suppl+3&rft.issue=&rft.spage=S151&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2008-2233E LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-05 N1 - Date created - 2009-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.2008-2233E ER - TY - JOUR T1 - The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1. AN - 66917416; 19075004 AB - DNA double-strand breaks can result from closely opposed breaks induced directly in complementary strands. Alternatively, double-strand breaks could be generated during repair of clustered damage, where the repair of closely opposed lesions has to be well coordinated. Using single and multiple mutants of Saccharomyces cerevisiae (budding yeast) that impede the interaction of DNA polymerase delta and the 5'-flap endonuclease Rad27/Fen1 with the PCNA sliding clamp, we show that the lack of coordination between these components during long-patch base excision repair of alkylation damage can result in many double-strand breaks within the chromosomes of nondividing haploid cells. This contrasts with the efficient repair of nonclustered methyl methanesulfonate-induced lesions, as measured by quantitative PCR and S1 nuclease cleavage of single-strand break sites. We conclude that closely opposed single-strand lesions are a unique threat to the genome and that repair of closely opposed strand damage requires greater spatial and temporal coordination between the participating proteins than does widely spaced damage in order to prevent the development of double-strand breaks. JF - Molecular and cellular biology AU - Ma, Wenjian AU - Panduri, Vijayalakshmi AU - Sterling, Joan F AU - Van Houten, Bennett AU - Gordenin, Dmitry A AU - Resnick, Michael A AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 1212 EP - 1221 VL - 29 IS - 5 KW - Saccharomyces cerevisiae Proteins KW - 0 KW - Methyl Methanesulfonate KW - AT5C31J09G KW - DNA Polymerase III KW - EC 2.7.7.- KW - Flap Endonucleases KW - EC 3.1.- KW - RAD27 protein, S cerevisiae KW - EC 3.1.11.5 KW - Index Medicus KW - Polymerase Chain Reaction KW - Mutation KW - Saccharomyces cerevisiae Proteins -- physiology KW - Saccharomyces cerevisiae -- genetics KW - DNA Repair KW - Flap Endonucleases -- physiology KW - DNA Polymerase III -- physiology KW - DNA Breaks, Double-Stranded UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66917416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=The+transition+of+closely+opposed+lesions+to+double-strand+breaks+during+long-patch+base+excision+repair+is+prevented+by+the+coordinated+action+of+DNA+polymerase+delta+and+Rad27%2FFen1.&rft.au=Ma%2C+Wenjian%3BPanduri%2C+Vijayalakshmi%3BSterling%2C+Joan+F%3BVan+Houten%2C+Bennett%3BGordenin%2C+Dmitry+A%3BResnick%2C+Michael+A&rft.aulast=Ma&rft.aufirst=Wenjian&rft.date=2009-03-01&rft.volume=29&rft.issue=5&rft.spage=1212&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.01499-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-10 N1 - Date created - 2009-02-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Apr 21;275(16):11865-73 [10766813] Mutat Res. 1990 Jul;231(1):11-30 [2195323] Radiat Res. 2000 Jun;153(6):805-12 [10825756] Curr Biol. 2000 Jul 27-Aug 10;10(15):919-22 [10959839] Methods. 2000 Oct;22(2):135-47 [11020328] Curr Genet. 2000 Nov;38(4):178-87 [11126776] Bioessays. 2001 Mar;23(3):270-81 [11223884] Genes Dev. 2001 Apr 15;15(8):945-54 [11316789] Nature. 2001 Jul 26;412(6845):456-61 [11473323] Radiat Prot Dosimetry. 2001;97(1):25-31 [11763354] EMBO J. 2002 Apr 2;21(7):1855-63 [11927569] Genetics. 2002 Apr;160(4):1409-22 [11973297] Proc Natl Acad Sci U S A. 2002 May 14;99(10):6860-5 [11983862] Curr Genet. 1991 Jul;20(1-2):33-7 [1934115] Mol Microbiol. 1991 Jul;5(7):1615-20 [1943698] Nature. 1993 Apr 22;362(6422):709-15 [8469282] J Biol Chem. 1994 Apr 15;269(15):11121-32 [8157639] J Biol Chem. 1995 Sep 22;270(38):22109-12 [7673186] Biochem J. 1997 Jul 1;325 ( Pt 1):1-16 [9224623] Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12863-8 [9371766] Nucleic Acids Res. 1998 Feb 15;26(4):932-41 [9461450] Exp Cell Res. 1998 Feb 25;239(1):152-60 [9511733] Nucleic Acids Res. 1998 Apr 15;26(8):2001-7 [9518496] EMBO J. 1998 Jul 1;17(13):3786-95 [9649448] J Biol Chem. 1998 Jul 31;273(31):19747-55 [9677405] J Biol Chem. 1998 Jul 31;273(31):19756-62 [9677406] Nucleic Acids Res. 1999 Feb 15;27(4):956-62 [9927726] J Biol Chem. 1999 Feb 12;274(7):4354-63 [9933638] Mol Cell Biol. 1999 Mar;19(3):1800-9 [10022867] Cancer Res. 1999 Jun 1;59(11):2522-6 [10363965] Mol Cell Biol. 1999 Aug;19(8):5373-82 [10409728] Genes Dev. 2004 Nov 15;18(22):2764-73 [15520275] Annu Rev Genet. 2004;38:445-76 [15568983] Nucleic Acids Res. 2005;33(1):260-71 [15647508] Genetics. 2005 Feb;169(2):575-82 [15520252] Cell Cycle. 2005 Feb;4(2):221-4 [15655350] Nucleic Acids Res. 2005;33(12):3799-811 [16009812] Mol Cell Biol. 2006 Apr;26(7):2490-500 [16537895] Methods Mol Biol. 2006;314:183-99 [16673882] DNA Repair (Amst). 2007 Apr 1;6(4):544-59 [17112792] DNA Repair (Amst). 2007 Apr 1;6(4):398-409 [17129767] Nature. 2007 Aug 16;448(7155):820-3 [17671506] Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14032-7 [17715301] Mutat Res. 2007 Dec 1;625(1-2):164-76 [17681555] Mol Biosyst. 2008 Jan;4(1):30-5 [18075671] Nucleic Acids Res. 2008 Apr;36(6):1836-46 [18267974] J Biol Chem. 2008 Dec 5;283(49):34129-40 [18927077] Free Radic Biol Med. 2002 Jul 1;33(1):1-14 [12086677] J Biol Chem. 2003 Jan 17;278(3):1728-34 [12424245] J Biol Chem. 2003 Sep 12;278(37):35279-85 [12832398] Hum Mol Genet. 2003 Dec 15;12(24):3331-42 [14570713] DNA Repair (Amst). 2004 Jan 5;3(1):1-12 [14697754] J Biol Chem. 2004 Jan 16;279(3):1907-15 [14594808] Biochemistry. 2004 Aug 31;43(34):11017-26 [15323560] Biochemistry. 1972 Sep 12;11(19):3618-23 [4559796] Mol Gen Genet. 1976 Jan 16;143(2):119-29 [765749] Proc Natl Acad Sci U S A. 1978 Mar;75(3):1274-8 [206891] Radiat Res. 1981 May;86(2):185-95 [7015409] Basic Life Sci. 1986;38:135-8 [3741327] Mutat Res. 1987 Nov;184(3):197-207 [2444878] Chem Res Toxicol. 2000 Apr;13(4):257-61 [10775325] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.01499-08 ER - TY - JOUR T1 - Radiotherapy for the management of locally advanced squamous cell carcinoma of the head and neck. AN - 66913441; 19036056 AB - Squamous cell carcinomas of the head and neck (SCCHN) affect approximately 35 000 people in the United States yearly. Although survival has improved with advances in therapy, patients with advanced stages of SCCHN continue to have a poor prognosis. An understanding of rationale for treatment selection, newer developments in therapy, and treatment toxicity is critical. Standard methods of treating locally advanced SCCHN are reviewed. Advances in medical and radiotherapeutic management are discussed and the toxicities of therapy are described. Postoperative chemoradiation is used in patients with high-risk characteristics. Induction chemotherapy and altered fractionation radiation treatment have been evaluated as alternatives to definitive chemo-radiotherapy. Targeted agents such as cetuximab may prove to increase survival with minimal increase in toxicity profile. Technological improvements such as the use of intensity-modulated radiation treatment have proven to decrease some debilitating side effects from radiation treatment. Locally advanced SCCHN continues to present a therapeutic challenge. Survival, local control, and quality of life are all goals of treatment. The optimal method of treating locally advanced SCCHN is the subject of ongoing research. Long-term side effects can be minimized with the use of newer technologies and with careful treatment planning. JF - Oral diseases AU - Ko, C AU - Citrin, D AD - Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 121 EP - 132 VL - 15 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Radiation-Sensitizing Agents KW - Dentistry KW - Combined Modality Therapy KW - Humans KW - Antineoplastic Agents -- therapeutic use KW - Chemotherapy, Adjuvant KW - Radiation Dosage KW - Carcinoma, Squamous Cell -- surgery KW - Head and Neck Neoplasms -- radiotherapy KW - Radiation-Sensitizing Agents -- therapeutic use KW - Head and Neck Neoplasms -- surgery KW - Head and Neck Neoplasms -- drug therapy KW - Carcinoma, Squamous Cell -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66913441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+diseases&rft.atitle=Radiotherapy+for+the+management+of+locally+advanced+squamous+cell+carcinoma+of+the+head+and+neck.&rft.au=Ko%2C+C%3BCitrin%2C+D&rft.aulast=Ko&rft.aufirst=C&rft.date=2009-03-01&rft.volume=15&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Oral+diseases&rft.issn=1601-0825&rft_id=info:doi/10.1111%2Fj.1601-0825.2008.01495.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-02-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Lancet. 2000 Mar 18;355(9208):949-55 [10768432] Int J Cancer. 2000 Apr 20;90(2):92-103 [10814959] Head Neck. 2000 Jul;22(4):393-7 [10862024] Int J Radiat Oncol Biol Phys. 2000 Aug 1;48(1):7-16 [10924966] J Clin Oncol. 2000 Oct 1;18(19):3339-45 [11013273] Br J Cancer. 2000 Dec;83(12):1594-8 [11189100] J Natl Cancer Inst. 2001 Feb 21;93(4):266-76 [11181773] J Clin Oncol. 2001 Apr 1;19(7):1961-9 [11283128] Head Neck. 2001 May;23(5):389-98 [11295813] Int J Radiat Oncol Biol Phys. 2001 Jul 1;50(3):695-704 [11395238] Radiother Oncol. 2001 Aug;60(2):173-80 [11439212] J Insur Med. 2001;33(3):235-8 [11558403] Mol Pharmacol. 2002 Jun;61(6):1297-302 [12021390] Oral Oncol. 2002 Sep;38(6):597-604 [12167438] J Clin Oncol. 2003 Jan 1;21(1):92-8 [12506176] J Clin Oncol. 2003 Jan 15;21(2):320-6 [12525525] Eur J Nucl Med Mol Imaging. 2003 May;30(5):695-704 [12632200] Radiother Oncol. 2003 Mar;66(3):253-62 [12742264] Radiother Oncol. 2003 Mar;66(3):291-302 [12742269] Int J Oral Maxillofac Surg. 2003 Jun;32(3):289-95 [12767877] Crit Rev Oral Biol Med. 2003;14(3):199-212 [12799323] Nat Rev Cancer. 2006 Sep;6(9):702-13 [16929324] CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66 [17237035] Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):396-402 [17321069] Int J Radiat Oncol Biol Phys. 2007 Jul 15;68(4):1131-9 [17446000] Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1289-98 [17560051] Oncologist. 2007 Aug;12(8):975-7 [17766657] Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S112-4 [17848275] J Clin Oncol. 2007 Nov 10;25(32):5121-7 [17991931] Int J Radiat Oncol Biol Phys. 2008 Jan 1;70(1):14-22 [17869018] J Clin Oncol. 2008 May 20;26(15):2489-96 [18487568] Cancer. 2008 Aug 1;113(3):497-507 [18521908] Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1088-95 [18707823] Nat Rev Cancer. 2004 Apr;4(4):277-84 [15057287] N Engl J Med. 2004 May 6;350(19):1945-52 [15128894] Cancer Treat Rev. 2004 Jun;30(4):369-84 [15145511] J Clin Oncol. 2004 Jun 1;22(11):2207-13 [15169810] Radiat Res. 1983 Aug;95(2):392-8 [6611856] Int J Radiat Oncol Biol Phys. 1985 Nov;11(11):1887-93 [2414254] Am J Clin Oncol. 1986 Apr;9(2):132-4 [3521255] Cancer. 1988 Apr 15;61(8):1535-42 [3349419] Int J Radiat Oncol Biol Phys. 1990 Jan;18(1):101-11 [2298613] Int J Radiat Oncol Biol Phys. 1990 Jul;19(1):3-8 [2380091] Baillieres Clin Endocrinol Metab. 1990 Mar;4(1):147-75 [2202287] Int J Radiat Oncol Biol Phys. 1990 Aug;19(2):401-7 [2394619] Int J Radiat Oncol Biol Phys. 1991 Jan;20(1):21-8 [1993628] N Engl J Med. 1991 Jun 13;324(24):1685-90 [2034244] Head Neck. 1991 Sep-Oct;13(5):420-3 [1938359] Int J Radiat Oncol Biol Phys. 1992;22(1):199-212 [1727119] N Engl J Med. 1993 Jan 21;328(3):184-94 [8417385] Radiother Oncol. 1992 Dec;25(4):231-41 [1480768] Cancer. 1993 Sep 1;72(5):1612-7 [8348492] Cancer Res. 1993 Sep 15;53(18):4322-8 [8364927] Int J Radiat Oncol Biol Phys. 1994 May 15;29(2):243-7 [8195014] Int J Radiat Oncol Biol Phys. 1995 Mar 30;31(5):1141-64 [7713779] J Clin Oncol. 1996 Mar;14(3):838-47 [8622032] J Natl Cancer Inst. 1996 May 1;88(9):583-9 [8609658] J Surg Oncol. 1996 Apr;61(4):281-3 [8627999] J Natl Cancer Inst. 1996 Jul 3;88(13):890-9 [8656441] Crit Rev Oncol Hematol. 1996 Oct;24(2):97-116 [8889368] Eur J Cancer B Oral Oncol. 1996 Sep;32B(5):281-92 [8944831] Head Neck. 1997 May;19(3):169-75 [9142514] J Clin Oncol. 1997 May;15(5):2050-5 [9164217] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Aug;84(2):149-53 [9269016] Radiother Oncol. 1997 Aug;44(2):111-21 [9288839] J Clin Oncol. 2003 Jul 1;21(13):2545-50 [12829674] J Clin Oncol. 2003 Jul 15;21(14):2787-99 [12860957] Int J Radiat Oncol Biol Phys. 2003 Sep 1;57(1):246-54 [12909240] Leuk Lymphoma. 2003 Jul;44(7):1165-72 [12916869] N Engl J Med. 2003 Nov 27;349(22):2091-8 [14645636] Radiother Oncol. 2003 Dec;69(3):237-45 [14644482] J Clin Oncol. 2004 Jan 1;22(1):69-76 [14657228] Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):674-81 [14967419] J Clin Oncol. 1998 Apr;16(4):1310-7 [9552031] N Engl J Med. 1998 Jun 18;338(25):1798-804 [9632446] Int J Radiat Oncol Biol Phys. 1999 Aug 1;45(1):47-52 [10477005] J Clin Oncol. 1999 Oct;17(10):3283-90 [10506631] J Natl Cancer Inst. 2004 Nov 17;96(22):1714-7 [15547184] Trends Mol Med. 2004 Dec;10(12):585-90 [15567328] Int J Radiat Oncol Biol Phys. 2004 Dec 1;60(5):1425-39 [15590174] Radiother Oncol. 2005 Mar;74(3):251-8 [15763305] J Clin Oncol. 2005 May 1;23(13):3008-15 [15860857] Nat Rev Cancer. 2005 May;5(5):341-54 [15864276] Pharmacotherapy. 2005 Apr;25(4):540-54 [15977916] Br J Cancer. 2005 Aug 8;93(3):279-86 [16012523] Int J Radiat Oncol Biol Phys. 2005 Nov 15;63(4):985-90 [16253773] Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):661-9 [16458773] N Engl J Med. 2006 Feb 9;354(6):567-78 [16467544] J Clin Oncol. 2006 Jun 10;24(17):2636-43 [16763277] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1601-0825.2008.01495.x ER - TY - JOUR T1 - Voriconazole-induced phototoxicity masquerading as chronic graft-versus-host disease of the skin in allogeneic hematopoietic cell transplant recipients. AN - 66904977; 19203729 AB - Systemic fungal infections pose a significant risk to patients following allogeneic hematopoietic cell transplantation (alloHCT). Voriconazole (Vfend, Pfizer) is an oral second-generation triazole antifungal agent that offers a broad spectrum of coverage against fungal species and is frequently utilized in the post-HCT setting. Herein, we describe 5 patients who were initially believed to be experiencing a flare of cutaneous chronic graft-versus-host disease (cGVHD), but who were actually exhibiting phototoxicity caused by voriconazole. A high index of suspicion for this adverse reaction in the post-alloHCT setting will prevent misdiagnosis and avoid inappropriate therapy for cGVHD. JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation AU - Patel, Asha R AU - Turner, Maria L AU - Baird, Kristin AU - Gea-Banacloche, Juan AU - Mitchell, Sandra AU - Pavletic, Steven Z AU - Wise, Barbara AU - Cowen, Edward W AD - Dermatology Branch, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 370 EP - 376 VL - 15 IS - 3 KW - Antifungal Agents KW - 0 KW - Pyrimidines KW - Triazoles KW - Voriconazole KW - JFU09I87TR KW - Index Medicus KW - Diagnosis, Differential KW - Humans KW - Adult KW - Retrospective Studies KW - Mycoses -- drug therapy KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Pyrimidines -- adverse effects KW - Antifungal Agents -- adverse effects KW - Graft vs Host Disease -- chemically induced KW - Graft vs Host Disease -- diagnosis KW - Graft vs Host Disease -- immunology KW - Pyrimidines -- therapeutic use KW - Dermatitis, Phototoxic -- etiology KW - Triazoles -- adverse effects KW - Graft vs Host Disease -- etiology KW - Hematopoietic Stem Cell Transplantation -- adverse effects KW - Antifungal Agents -- therapeutic use KW - Dermatitis, Phototoxic -- diagnosis KW - Triazoles -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66904977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.atitle=Voriconazole-induced+phototoxicity+masquerading+as+chronic+graft-versus-host+disease+of+the+skin+in+allogeneic+hematopoietic+cell+transplant+recipients.&rft.au=Patel%2C+Asha+R%3BTurner%2C+Maria+L%3BBaird%2C+Kristin%3BGea-Banacloche%2C+Juan%3BMitchell%2C+Sandra%3BPavletic%2C+Steven+Z%3BWise%2C+Barbara%3BCowen%2C+Edward+W&rft.aulast=Patel&rft.aufirst=Asha&rft.date=2009-03-01&rft.volume=15&rft.issue=3&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.issn=1523-6536&rft_id=info:doi/10.1016%2Fj.bbmt.2008.12.491 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2009-02-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Dermatol. 2000 Jul;136(7):849-54 [10890986] J Drugs Dermatol. 2007 Oct;6(10):1042-4 [17966183] Pharmacol Rev. 2001 Sep;53(3):357-79 [11546834] Clin Exp Dermatol. 2001 Nov;26(8):648-53 [11722447] Pediatr Infect Dis J. 2002 Mar;21(3):240-8 [12005089] N Engl J Med. 2002 Aug 8;347(6):408-15 [12167683] Blood. 2002 Dec 15;100(13):4358-66 [12393425] Clin Infect Dis. 2003 Jun 15;36(12):1619-22 [12802765] Eur J Clin Microbiol Infect Dis. 2004 Aug;23(8):656-7 [15248093] Drugs. 2004;64(18):1997-2020 [15341494] Int J Dermatol. 2004 Oct;43(10):768-71 [15485539] Dermatol Clin. 1986 Apr;4(2):223-30 [3456856] Arch Dermatol Res. 1993;285(8):499-501 [7903850] N Engl J Med. 1994 Nov 10;331(19):1272-85 [7794310] J Clin Epidemiol. 1998 Aug;51(8):703-8 [9743319] Pediatr Dermatol. 2004 Nov-Dec;21(6):675-8 [15575856] J Am Acad Dermatol. 2005 May;52(5 Suppl 1):S81-5 [15858516] J Am Acad Dermatol. 2005 Aug;53(2):341-5 [16021136] J Cyst Fibros. 2005 Dec;4(4):215-20 [16243008] Biol Blood Marrow Transplant. 2005 Dec;11(12):945-56 [16338616] Biol Blood Marrow Transplant. 2006 Apr;12(4):375-96 [16545722] Ann Dermatol Venereol. 2006 Apr;133(4):330-2 [16733446] Clin Infect Dis. 2007 Jan 1;44(1):2-12 [17143808] Clin Infect Dis. 2007 Feb 1;44(3):402-9 [17205448] Clin Infect Dis. 2007 Feb 15;44(4):531-40 [17243056] N Engl J Med. 2007 Jan 25;356(4):335-47 [17251530] Photodermatol Photoimmunol Photomed. 2007 Feb;23(1):29-31 [17254033] Clin Infect Dis. 2007 Mar 1;44(5):e55-6 [17278050] Farm Hosp. 2006 Nov-Dec;30(6):386-7 [17298198] Expert Opin Drug Saf. 2007 Jul;6(4):431-43 [17688387] Arch Dermatol. 2001 Jan;137(1):75-6 [11176664] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbmt.2008.12.491 ER - TY - JOUR T1 - Prospective comparison of course of disability in antipsychotic-treated and untreated schizophrenia patients. AN - 66866088; 19053968 AB - To compare the course of disability in schizophrenia patients receiving antipsychotics and those remaining untreated in a rural community. Of 215 schizophrenia patients identified in a rural south Indian community, 58% were not receiving antipsychotics. Trained raters assessed the disability in 190 of these at baseline and after 1 year. The course of disability in those who remained untreated was compared with that in those who received antipsychotics. Mean disability scores remained virtually unchanged in those who remained untreated, but showed a significant decline (indicating decrement in disability) in those who continued to receive antipsychotics and in those in whom antipsychotic treatment was initiated (P < 0.001; group x occasion effect). The proportion of patients classified as 'disabled' declined significantly in the treated group (P < 0.01), but remained the same in the untreated group. Disability in untreated schizophrenia patients remains unchanged over time. Treatment with antipsychotics in the community results in a considerable reduction in disability. JF - Acta psychiatrica Scandinavica AU - Thirthalli, J AU - Venkatesh, B K AU - Kishorekumar, K V AU - Arunachala, U AU - Venkatasubramanian, G AU - Subbakrishna, D K AU - Gangadhar, B N AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India. jagatth@yahoo.com Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 209 EP - 217 VL - 119 IS - 3 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Socioeconomic Factors KW - Alcoholism -- epidemiology KW - Social Adjustment KW - Humans KW - Adult KW - Activities of Daily Living -- psychology KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Psychometrics KW - Male KW - Female KW - India KW - Antipsychotic Agents -- therapeutic use KW - Disability Evaluation KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Schizophrenia -- epidemiology KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66866088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+psychiatrica+Scandinavica&rft.atitle=Prospective+comparison+of+course+of+disability+in+antipsychotic-treated+and+untreated+schizophrenia+patients.&rft.au=Thirthalli%2C+J%3BVenkatesh%2C+B+K%3BKishorekumar%2C+K+V%3BArunachala%2C+U%3BVenkatasubramanian%2C+G%3BSubbakrishna%2C+D+K%3BGangadhar%2C+B+N&rft.aulast=Thirthalli&rft.aufirst=J&rft.date=2009-03-01&rft.volume=119&rft.issue=3&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Acta+psychiatrica+Scandinavica&rft.issn=1600-0447&rft_id=info:doi/10.1111%2Fj.1600-0447.2008.01299.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-23 N1 - Date created - 2009-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0447.2008.01299.x ER - TY - JOUR T1 - A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM). AN - 66853714; 19018475 AB - Twenty-two patients with recurrent glioblastoma (GBM) were prospectively treated with everolimus and gefitinib, designed to test the combined inhibition of mammalian target of rapamycin (mTOR) and epidermal growth factor receptor (EGFR) as part of a larger clinical trial. The primary endpoint was radiographic response rate. Secondary endpoints included progression-free survival and correlation of molecular profiles with treatment response. 36% of patients had stable disease and 14% a partial response; however, responses were not durable and only one patient was progression-free at six months. Radiographic changes were not well characterized by conventional response criteria, and implied differential effects of therapy within the tumor and/or antiangiogenic effects. EGFR and PTEN status did not clearly predict response to treatment. JF - Journal of neuro-oncology AU - Kreisl, Teri N AU - Lassman, Andrew B AU - Mischel, Paul S AU - Rosen, Neal AU - Scher, Howard I AU - Teruya-Feldstein, Julie AU - Shaffer, David AU - Lis, Eric AU - Abrey, Lauren E AD - Neuro-Oncology Branch, National Cancer Institute, 9030 Old Georgetown Road, Bethesda, MD 20892, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 99 EP - 105 VL - 92 IS - 1 SN - 0167-594X, 0167-594X KW - Quinazolines KW - 0 KW - Everolimus KW - 9HW64Q8G6G KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - PTEN Phosphohydrolase KW - EC 3.1.3.67 KW - PTEN protein, human KW - gefitinib KW - S65743JHBS KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Sirolimus -- administration & dosage KW - Disease-Free Survival KW - Humans KW - Aged KW - Pilot Projects KW - Receptor, Epidermal Growth Factor -- biosynthesis KW - Sirolimus -- adverse effects KW - Quinazolines -- administration & dosage KW - Kaplan-Meier Estimate KW - PTEN Phosphohydrolase -- biosynthesis KW - Adult KW - Middle Aged KW - Quinazolines -- adverse effects KW - Female KW - Male KW - Sirolimus -- analogs & derivatives KW - Brain Neoplasms -- drug therapy KW - Neoplasm Recurrence, Local -- drug therapy KW - Glioblastoma -- mortality KW - Brain Neoplasms -- mortality KW - Glioblastoma -- metabolism KW - Brain Neoplasms -- metabolism KW - Glioblastoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66853714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuro-oncology&rft.atitle=A+pilot+study+of+everolimus+and+gefitinib+in+the+treatment+of+recurrent+glioblastoma+%28GBM%29.&rft.au=Kreisl%2C+Teri+N%3BLassman%2C+Andrew+B%3BMischel%2C+Paul+S%3BRosen%2C+Neal%3BScher%2C+Howard+I%3BTeruya-Feldstein%2C+Julie%3BShaffer%2C+David%3BLis%2C+Eric%3BAbrey%2C+Lauren+E&rft.aulast=Kreisl&rft.aufirst=Teri&rft.date=2009-03-01&rft.volume=92&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuro-oncology&rft.issn=0167594X&rft_id=info:doi/10.1007%2Fs11060-008-9741-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-30 N1 - Date created - 2009-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11060-008-9741-z ER - TY - JOUR T1 - Protecting Patients in Health Information Exchange: A Defense of the HIPAA Privacy Rule AN - 58820017; 2008-291279 AB - Regional health information organizations (RHIOs) rapidly integrate and deliver patient information to clinicians from multiple independent care organizations. By providing such information, they can reduce health care costs and improve safety. Special concerns about privacy arise as these regional systems connect nationally. We should add special barriers beyond the protections of the Health Insurance Portability and Accountability Act (HIPAA) to protect against surprises at the national level. At the local level, we should remain within the HIPAA rules because the application of additional barriers to RHIO access would interfere with efficient and safe care. Adapted from the source document. JF - Health Affairs AU - McDonald, Clement AD - Lister Hill National Center for Biomedical Communications, Bethesda, Maryland clemmcdonald@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 447 EP - 449 PB - Project HOPE, Bethesda MD VL - 28 IS - 2 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Medicine and health care KW - Government - Information policy KW - Human rights - Civil and political rights KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - Economic conditions and policy - Economic theory KW - Cost KW - Information policy KW - Privacy KW - Health insurance KW - Patients KW - Medical service KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58820017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Protecting+Patients+in+Health+Information+Exchange%3A+A+Defense+of+the+HIPAA+Privacy+Rule&rft.au=McDonald%2C+Clement&rft.aulast=McDonald&rft.aufirst=Clement&rft.date=2009-03-01&rft.volume=28&rft.issue=2&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.28.2.447 LA - English DB - PAIS Index N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medical service; Patients; Information policy; Privacy; Health insurance; Cost DO - http://dx.doi.org/10.1377/hlthaff.28.2.447 ER - TY - JOUR T1 - The Effectiveness of a Mutual-Help Group Activity for Drug Users and Family Members in Japan AN - 57302072; 200915537 AB - Aims: To understand the efficacy of a mutual-help group activity for drug users and family members in terms of: (a) family members' behavioral changes (b) treatment engagement rate of the drug users, and (c) life satisfaction of family members. Methods: A total of 186 family members answered questionnaires. Results: Attending the group changed the family members' behaviors. The treatment engagement rates within 1, 6, and 12 months for untreated drug users were 23.2%, 39.2%, and 52.3%, respectively. The well-being (Subjective Well-Being Inventory [SUBI]) of long-term group members is higher than that of short-term group members. Adapted from the source document. JF - Substance Use & Misuse AU - Kondo, Ayumi AU - Wada, Kiyoshi AD - Department of Drug Dependence Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 472 EP - 489 PB - Taylor & Francis, Philadelphia PA VL - 44 IS - 4 SN - 1082-6084, 1082-6084 KW - Short term KW - Drug addicts KW - Subjective wellbeing KW - Group activities KW - Relatives KW - Japan KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57302072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=The+Effectiveness+of+a+Mutual-Help+Group+Activity+for+Drug+Users+and+Family+Members+in+Japan&rft.au=Kondo%2C+Ayumi%3BWada%2C+Kiyoshi&rft.aulast=Kondo&rft.aufirst=Ayumi&rft.date=2009-03-01&rft.volume=44&rft.issue=4&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1080%2F10826080701801501 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Relatives; Drug addicts; Group activities; Subjective wellbeing; Short term; Japan DO - http://dx.doi.org/10.1080/10826080701801501 ER - TY - JOUR T1 - Conceptual problems in laypersons' understanding of individualized cancer risk: a qualitative study AN - 57290421; 200914975 AB - Objective To explore laypersons' understanding of individualized cancer risk estimates, and to identify conceptual problems that may limit this understanding. Background Risk prediction models are increasingly used to provide people with information about their individual risk of cancer and other diseases. However, laypersons may have difficulty understanding individualized risk information, because of conceptual as well as computational problems. Design A qualitative study was conducted using focus groups. Semi-structured interviews explored participants' understandings of the concept of risk, and their interpretations of a hypothetical individualized colorectal cancer risk estimate. Setting and participants Eight focus groups were conducted with 48 adults aged 50--74 years residing in two major US metropolitan areas. Participants had high school or greater education, some familiarity with information technology, and no personal or family history of cancer. Results Several important conceptual problems were identified. Most participants thought of risk not as a neutral statistical concept, but as signifying danger and emotional threat, and viewed cancer risk in terms of concrete risk factors rather than mathematical probabilities. Participants had difficulty acknowledging uncertainty implicit to the concept of risk, and judging the numerical significance of individualized risk estimates. The most challenging conceptual problems related to conflict between subjective and objective understandings of risk, and difficulties translating aggregate-level objective risk estimates to the individual level. Conclusions Several conceptual problems limit laypersons' understanding of individualized cancer risk information. These problems have implications for future research on health numeracy, and for the application of risk prediction models in clinical and public health settings. Accepted for publication 31 August 2008. Adapted from the source document. JF - Health Expectations AU - Han, Paul K J AU - Lehman, Thomas C AU - Massett, Holly AU - Lee, Simon J C AU - Klein, William M P AU - Freedman, Andrew N AD - Medical Officer, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD hanp@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 4 EP - 17 PB - Blackwell Publishing, Oxford UK VL - 12 IS - 1 SN - 1369-6513, 1369-6513 KW - High schools KW - Information technology KW - Metropolitan areas KW - Risks KW - Cancer KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57290421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Expectations&rft.atitle=Conceptual+problems+in+laypersons%27+understanding+of+individualized+cancer+risk%3A+a+qualitative+study&rft.au=Han%2C+Paul+K+J%3BLehman%2C+Thomas+C%3BMassett%2C+Holly%3BLee%2C+Simon+J+C%3BKlein%2C+William+M+P%3BFreedman%2C+Andrew+N&rft.aulast=Han&rft.aufirst=Paul+K&rft.date=2009-03-01&rft.volume=12&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Health+Expectations&rft.issn=13696513&rft_id=info:doi/10.1111%2Fj.1369-7625.2008.00524.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - HEHPFM N1 - SubjectsTermNotLitGenreText - Cancer; Risks; Public health; Information technology; High schools; Metropolitan areas DO - http://dx.doi.org/10.1111/j.1369-7625.2008.00524.x ER - TY - JOUR T1 - Personality and career success: Concurrent and longitudinal relations AN - 57287180; 200913148 AB - The present research addresses the dynamic transaction between extrinsic (occupational prestige, income) and intrinsic (job satisfaction) career success and the Five-Factor Model (FFM) of personality. Participants (N = 731) completed a comprehensive measure of personality and reported their job title, annual income and job satisfaction; a subset of these participants (n = 302) provided the same information approximately 10 years later. Measured concurrently, emotionally stable and conscientious participants reported higher incomes and job satisfaction. Longitudinal analyses revealed that, among younger participants, higher income at baseline predicted decreases in Neuroticism and baseline Extraversion predicted increases in income across the 10 years. Results suggest that the mutual influence of career success and personality is limited to income and occurs early in the career. [Copyright John Wiley and Sons, Ltd.] JF - European Journal of Personality AU - Sutin, Angelina R AU - Costa, Paul T, Jr AU - Miech, Richard AU - Eaton, William W AD - National Institute on Aging, NIH, DHHS, USA sutina@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 71 EP - 84 PB - John Wiley & Sons, Chichester UK VL - 23 IS - 2 SN - 0890-2070, 0890-2070 KW - Job satisfaction KW - Occupational prestige KW - Neuroticism KW - Personality KW - Personality tests KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57287180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Personality&rft.atitle=Personality+and+career+success%3A+Concurrent+and+longitudinal+relations&rft.au=Sutin%2C+Angelina+R%3BCosta%2C+Paul+T%2C+Jr%3BMiech%2C+Richard%3BEaton%2C+William+W&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2009-03-01&rft.volume=23&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Personality&rft.issn=08902070&rft_id=info:doi/10.1002%2Fper.704 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - EJPEEU N1 - SubjectsTermNotLitGenreText - Personality; Job satisfaction; Personality tests; Neuroticism; Occupational prestige DO - http://dx.doi.org/10.1002/per.704 ER - TY - JOUR T1 - Neuropsychological status of bipolar I disorder: impact of psychosis AN - 57287022; 200910452 AB - Background -- The presence of schizotypal personality traits in some people with bipolar disorder, together with reports of greater cognitive dysfunction in patients with a history of psychotic features compared with patients without such a history, raises questions about the nosological relationship between bipolar disorder with psychotic features and bipolar disorder without psychotic features. Aims -- To test the impact of a history of DSM-IV-defined psychosis on the neuropsychological status of participants with bipolar disorder while statistically controlling for confounding factors such as mood, medication, alcohol misuse/dependence and childhood abuse, and to evaluate the impact of schizotypal personality traits (and thus potential vulnerability to psychotic illness) on the cognitive performance of people with bipolar disorder and their healthy relatives. Method -- Nuropsychological data were obtained for 25 participants with type 1 bipolar disorder and a history of psychosis, 24 with type 1 bipolar disorder but no history of psychosis and 61 unaffected relatives. Schizotypal traits were measured with the Schizotypal Personality Scale (STA). Childhood trauma was measured with the Childhood Trauma Questionnaire. Results -- The group with a history of psychosis performed significantly worse than the healthy relatives on measures of verbal working memory, cognitive flexibility and declarative memory. Nevertheless, the two bipolar disorder groups did not differ significantly from each other on any cognitive measure. Scores on the STA were negatively associated with verbal working and declarative memory, but positively associated with visual recall memory. Conclusions -- 'Psychotic' and 'non-psychotic' subtypes of bipolar disorder may lie on a nosological continuum that is most clearly defined by verbal memory impairment. Declaration of interest -- None. Adapted from the source document. JF - The British Journal of Psychiatry AU - Savitz, Jonathan AU - van der Merwe, Lize AU - Stein, Dan J AU - Solms, Mark AU - Ramesar, Rajkumar AD - Room 200, B15K, North Drive, National Institutes of Health, Bethesda, MD 20892, USA savitzj@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 243 EP - 251 PB - Royal College of Psychiatrists, London UK VL - 194 IS - 3 SN - 0007-1250, 0007-1250 KW - Schizotypal personality KW - Neuropsychological aspects KW - Bipolar affective disorder KW - Psychoses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57287022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Neuropsychological+status+of+bipolar+I+disorder%3A+impact+of+psychosis&rft.au=Savitz%2C+Jonathan%3Bvan+der+Merwe%2C+Lize%3BStein%2C+Dan+J%3BSolms%2C+Mark%3BRamesar%2C+Rajkumar&rft.aulast=Savitz&rft.aufirst=Jonathan&rft.date=2009-03-01&rft.volume=194&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.108.052001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Bipolar affective disorder; Psychoses; Neuropsychological aspects; Schizotypal personality DO - http://dx.doi.org/10.1192/bjp.bp.108.052001 ER - TY - JOUR T1 - Commentary on 'A roadmap for the prevention of dementia II. Leon Thal Symposium 2008.' Alzheimer's disease translational research programs at the National Institute on Aging AN - 57281907; 200910144 AB - Abstract not available. JF - Alzheimer's & Dementia AU - Petanceska, Suzana AU - Ryan, Laurie AU - Silverberg, Nina AU - Buckholtz, Neil AD - Division of Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 130 EP - 132 PB - Elsevier Ltd, The Netherlands VL - 5 IS - 2 SN - 1552-5260, 1552-5260 KW - Ageing KW - Prevention KW - Alzheimer's disease KW - Dementia KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alzheimer%27s+%26+Dementia&rft.atitle=Commentary+on+%27A+roadmap+for+the+prevention+of+dementia+II.+Leon+Thal+Symposium+2008.%27+Alzheimer%27s+disease+translational+research+programs+at+the+National+Institute+on+Aging&rft.au=Petanceska%2C+Suzana%3BRyan%2C+Laurie%3BSilverberg%2C+Nina%3BBuckholtz%2C+Neil&rft.aulast=Petanceska&rft.aufirst=Suzana&rft.date=2009-03-01&rft.volume=5&rft.issue=2&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Alzheimer%27s+%26+Dementia&rft.issn=15525260&rft_id=info:doi/10.1016%2Fj.jalz.2009.01.014 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Dementia; Ageing; Alzheimer's disease; Prevention DO - http://dx.doi.org/10.1016/j.jalz.2009.01.014 ER - TY - JOUR T1 - Challenges to and Lessons Learned from Conducting Palliative Care Research AN - 57281545; 200910025 AB - In response to a 2005 solicitation from the U.S. National Institutes of Health, 16 investigators received funding to test interventions that would reduce the barriers that prevent cancer patients from receiving adequate and appropriate symptom management therapies. Since the awards have been issued, the investigators have met two times and have identified a number of challenges to implementing their respective studies. A survey was conducted that focused on their experiences with hiring and retaining study personnel, gaining Institutional Review Board approval, incurring unexpected costs, challenges to accruing participants, and a listing of standard measures used in the study. The survey was completed online by the Principal Investigator for each project in late 2006 and the initial results were confirmed one year later by resending the initial survey and by a follow-up telephone call. All but one Principal Investigator completed the survey. Obtaining Institutional Review Board approval, hiring and recruiting research personnel, establishing subcontracts, and accruing research subjects were the primary challenges experienced by the investigators. This palliative care solicitation achieved more than its original intent of stimulating research in overcoming barriers to delivering cancer symptom management, palliative care and end-of-life care. From a survey on the challenges and issues that emerged from their projects, grantees were able to identify specific hurdles and their unique solutions that may help other investigators as they plan their program of research. [Copyright 2009 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc.] JF - Journal of Pain and Symptom Management AU - O'Mara, Ann M AU - Germain, Diane St AU - Ferrell, Betty AU - Bornemann, Tami AD - National Cancer Institute, Bethesda, Maryland Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 387 EP - 394 PB - Elsevier, New York NY VL - 37 IS - 3 SN - 0885-3924, 0885-3924 KW - Review bodies KW - Barriers KW - Medical research KW - Palliative care KW - Service provision KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pain+and+Symptom+Management&rft.atitle=Challenges+to+and+Lessons+Learned+from+Conducting+Palliative+Care+Research&rft.au=O%27Mara%2C+Ann+M%3BGermain%2C+Diane+St%3BFerrell%2C+Betty%3BBornemann%2C+Tami&rft.aulast=O%27Mara&rft.aufirst=Ann&rft.date=2009-03-01&rft.volume=37&rft.issue=3&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pain+and+Symptom+Management&rft.issn=08853924&rft_id=info:doi/10.1016%2Fj.jpainsymman.2008.03.014 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JSPME2 N1 - SubjectsTermNotLitGenreText - Palliative care; Service provision; Medical research; Barriers; Review bodies; Cancer DO - http://dx.doi.org/10.1016/j.jpainsymman.2008.03.014 ER - TY - JOUR T1 - The role of cannabis use within a dimensional approach to cannabis use disorders AN - 57277588; 200905788 AB - Context Cannabis consumption is central to diagnosis of cannabis use disorders; yet, most research on cannabis disorders has focused just on diagnosis or criteria. The present study examines the ability of a frequency and quantity measure of cannabis use as well as cannabis abuse and dependence criteria to discriminate between individuals across the cannabis use disorder continuum. Method A representative sample of USA adults in 2001-2002 (N = 43,093) were queried about the past year frequency of cannabis use and each Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) cannabis abuse and dependence criterion. Factor analysis and item response theory (IRT) models were used to define the relationship between observed responses and the underlying unobserved latent trait (cannabis use disorder severity) among past year cannabis users (n = 1603). Results Factor analyses demonstrated a good fit for a one-factor model both with and without the cannabis use criterion and no differential criterion functioning was demonstrated across sex. The IRT model including the cannabis use criterion had discriminatory power comparable to the model without the cannabis use criterion and exceeded the informational value of the model without the cannabis use criterion in mild and moderate ranges of the severity continuum. Discussion Factor and IRT analyses disprove the validity of the DSM-IV abuse and dependence distinction: A single dimension represented the criteria rather than the two implied by the separate abuse/dependence categories. IRT models identified some dependence criteria to be among the mildest and some abuse criteria to be among the most severe-results inconsistent with the interpretation of DSM-IV cannabis abuse as a milder disorder or prodrome of cannabis dependence. The consumption criterion defined the mild end of the cannabis use disorder continuum and its excellent psychometric properties supported its consideration for inclusion in the next edition of DSM as a criterion for cannabis use disorders. Additional work is needed to identify candidate consumption criteria across all drugs that apply to the milder end of the severity continuum while also improving overall model performance and clinical diagnostic utility. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Compton, Wilson M AU - Saha, Tulshi D AU - Conway, Kevin P AU - Grant, Bridget F AD - Division of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, MSC 9589, Bethesda, MD 20892-9589, USA wcompton@nida.nih.gov Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 SP - 221 EP - 227 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 100 IS - 3 SN - 0376-8716, 0376-8716 KW - Cannabis use disorders IRT analysis Cannabis use KW - Diagnostic and Statistical Manual IV KW - Substance abuse disorders KW - Cannabis KW - Item response theory KW - Dependency KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57277588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=The+role+of+cannabis+use+within+a+dimensional+approach+to+cannabis+use+disorders&rft.au=Compton%2C+Wilson+M%3BSaha%2C+Tulshi+D%3BConway%2C+Kevin+P%3BGrant%2C+Bridget+F&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2009-03-01&rft.volume=100&rft.issue=3&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2008.10.009 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Item response theory; Cannabis; Substance abuse disorders; Dependency; Diagnostic and Statistical Manual IV DO - http://dx.doi.org/10.1016/j.drugalcdep.2008.10.009 ER - TY - JOUR T1 - Risk-taking propensity changes throughout the course of residential substance abuse treatment AN - 57277050; 200905389 AB - High rates of relapse following treatment have compelled researchers to elucidate the individual difference factors that change among those who receive substance abuse treatment. Previous research has suggested that trait-disinhibition variables may be of particular relevance. Given that these variables are primarily considered to be trait-level factors, the extent to which they are malleable by treatment is an important consideration. Thus, the purpose of this study was to examine the effect of a residential substance abuse treatment program on specific trait-disinhibition variables (e.g., risk-taking and impulsivity). A sample of 81 inner-city substance users was assessed on self-report and behavioral indicators of trait-disinhibition over a 30-day course of treatment. Risk-taking propensity was found to significantly decrease from pre- to post-treatment. Results are discussed with respect to implications for better understanding the factors that may operate as mechanisms of change during treatment, thereby having the potential to inform substance abuse prevention and treatment programs. [Copyright Elsevier Ltd.] JF - Personality and Individual Differences AU - Aklin, Will M AU - Tull, Matthew T AU - Kahler, Christopher W AU - Lejuez, C W AD - Department of Psychiatry and Behavioral Sciences, Behavioral Pharmacology and Substance Abuse, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224-6823, USA aklinwm@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 454 EP - 459 PB - Elsevier, UK VL - 46 IS - 4 SN - 0191-8869, 0191-8869 KW - Risk-taking behaviors Assessment Substance abuse Treatment Trait-disinhibition KW - Individual differences KW - Residential treatment KW - Risk taking KW - Impulsivity KW - Selfreport KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57277050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Individual+Differences&rft.atitle=Risk-taking+propensity+changes+throughout+the+course+of+residential+substance+abuse+treatment&rft.au=Aklin%2C+Will+M%3BTull%2C+Matthew+T%3BKahler%2C+Christopher+W%3BLejuez%2C+C+W&rft.aulast=Aklin&rft.aufirst=Will&rft.date=2009-03-01&rft.volume=46&rft.issue=4&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=Personality+and+Individual+Differences&rft.issn=01918869&rft_id=info:doi/10.1016%2Fj.paid.2008.11.018 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - PEIDD9 N1 - SubjectsTermNotLitGenreText - Substance abuse; Risk taking; Residential treatment; Selfreport; Impulsivity; Individual differences DO - http://dx.doi.org/10.1016/j.paid.2008.11.018 ER - TY - JOUR T1 - Using the RE-AIM Framework to Evaluate the Statewide Dissemination of a School-Based Physical Activity and Nutrition Curriculum: "Exercise Your Options" AN - 57258920; 200908773 AB - A pilot study in 16 middle-school classrooms examined the reach, efficacy, adoption, implementation, & maintenance of a physical activity & nutrition curriculum for middle-school students. An eight-lesson nutrition & physical activity curriculum, "Exercise Your Options" (EYO), including a teacher guide, video clips, a student activity booklet & ancillary materials was made available to teachers. The EYO program reached 234,442 middle-school students in California. During the program, total physical activity increased, whereas watching TV/DVDs & playing electronic games/computer use decreased. Intake of dairy products increased, whereas consumption of sugars/sweets decreased. During the past five years, 51% of all middle-school students in California were exposed to the program. The EYO program showed its potential for moderate to high public health impact among California middle-school students. Adapted from the source document. JF - American Journal of Health Promotion AU - Dunton, Genevieve F AU - Lagloire, Renee AU - Robertson, Trina AD - Cancer Prevention Fellowship Program, Health Promotion Research Branch, Behavioral Research Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 229 EP - 232 PB - AJHP Inc, West Bloomfield MI VL - 23 IS - 4 SN - 0890-1171, 0890-1171 KW - Exercise KW - Dietary Habits KW - Schools KW - Intervention KW - Information Dissemination KW - Prevention Research KW - Nutrition programmes KW - Curriculum KW - Physical activity KW - Pilot studies KW - Evaluative research KW - Middle schools KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57258920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=Using+the+RE-AIM+Framework+to+Evaluate+the+Statewide+Dissemination+of+a+School-Based+Physical+Activity+and+Nutrition+Curriculum%3A+%22Exercise+Your+Options%22&rft.au=Dunton%2C+Genevieve+F%3BLagloire%2C+Renee%3BRobertson%2C+Trina&rft.aulast=Dunton&rft.aufirst=Genevieve&rft.date=2009-03-01&rft.volume=23&rft.issue=4&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHPED N1 - SubjectsTermNotLitGenreText - Middle schools; Physical activity; Nutrition programmes; Curriculum; Evaluative research; Pilot studies ER - TY - CPAPER T1 - Nitrite in diet and mitochondrial cytoprotection T2 - 2009 Gordon Research Conference on Nitric Oxide AN - 41942727; 5115496 JF - 2009 Gordon Research Conference on Nitric Oxide AU - Shiva, Sruti Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Nitrite KW - Diets KW - Mitochondria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41942727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.atitle=Nitrite+in+diet+and+mitochondrial+cytoprotection&rft.au=Shiva%2C+Sruti&rft.aulast=Shiva&rft.aufirst=Sruti&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=nitric LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasticity of Regulatory T Cells during Infections T2 - 2009 Keystone Symposia on Regulatory T Cells (C5) AN - 41938951; 5114254 JF - 2009 Keystone Symposia on Regulatory T Cells (C5) AU - Belkaid, Yasmine Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Infection KW - Plasticity KW - Lymphocytes T KW - Immunoregulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41938951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.atitle=Plasticity+of+Regulatory+T+Cells+during+Infections&rft.au=Belkaid%2C+Yasmine&rft.aulast=Belkaid&rft.aufirst=Yasmine&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Privilege, Tregs and Autoimmunity T2 - 2009 Keystone Symposia on Regulatory T Cells (C5) AN - 41938895; 5114253 JF - 2009 Keystone Symposia on Regulatory T Cells (C5) AU - Caspi, Rachel Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Lymphocytes T KW - Immune privilege KW - Autoimmunity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41938895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.atitle=Immune+Privilege%2C+Tregs+and+Autoimmunity&rft.au=Caspi%2C+Rachel&rft.aulast=Caspi&rft.aufirst=Rachel&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - STAT3 Promotes Pathogenic T Cell Development in a Mouse Model of Colitis T2 - 2009 Keystone Symposia on Regulatory T Cells (C5) AN - 41929699; 5114229 JF - 2009 Keystone Symposia on Regulatory T Cells (C5) AU - Durant, Lydia Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Colitis KW - Animal models KW - Lymphocytes T KW - Stat3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41929699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.atitle=STAT3+Promotes+Pathogenic+T+Cell+Development+in+a+Mouse+Model+of+Colitis&rft.au=Durant%2C+Lydia&rft.aulast=Durant&rft.aufirst=Lydia&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A distinct gene expression signature of inducible nitric oxide synthase in estrogen receptor-negative human breast tumors T2 - 2009 Gordon Research Conference on Nitric Oxide AN - 41917941; 5115504 JF - 2009 Gordon Research Conference on Nitric Oxide AU - Ambs, Stefan Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Tumors KW - Estrogens KW - Nitric-oxide synthase KW - Gene expression KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41917941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.atitle=A+distinct+gene+expression+signature+of+inducible+nitric+oxide+synthase+in+estrogen+receptor-negative+human+breast+tumors&rft.au=Ambs%2C+Stefan&rft.aulast=Ambs&rft.aufirst=Stefan&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=nitric LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of NO in Carcinogenesis T2 - 2009 Gordon Research Conference on Nitric Oxide AN - 41917298; 5115503 JF - 2009 Gordon Research Conference on Nitric Oxide AU - Harris, Curtis Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Carcinogenesis KW - Nitric oxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41917298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.atitle=Mechanisms+of+NO+in+Carcinogenesis&rft.au=Harris%2C+Curtis&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=nitric LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Control of Immune Responses by Natural and Adaptive Regulatory T Cells T2 - 2009 Keystone Symposia on Regulatory T Cells (C5) AN - 41908415; 5114267 JF - 2009 Keystone Symposia on Regulatory T Cells (C5) AU - Shevach, Ethan Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Lymphocytes T KW - Immunoregulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41908415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.atitle=Control+of+Immune+Responses+by+Natural+and+Adaptive+Regulatory+T+Cells&rft.au=Shevach%2C+Ethan&rft.aulast=Shevach&rft.aufirst=Ethan&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Novel H2S releasing NSAIDs in Non-Small Lung Cancer T2 - 2009 Gordon Research Conference on Nitric Oxide AN - 41905502; 5115511 JF - 2009 Gordon Research Conference on Nitric Oxide AU - Moody, Terry Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Lung cancer KW - Hydrogen sulfide KW - Nonsteroidal antiinflammatory drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41905502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.atitle=Role+of+Novel+H2S+releasing+NSAIDs+in+Non-Small+Lung+Cancer&rft.au=Moody%2C+Terry&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=nitric LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Highly Polarized Th1 Cells as Regulatory T Cells T2 - 2009 Keystone Symposia on Regulatory T Cells (C5) AN - 41904478; 5114241 JF - 2009 Keystone Symposia on Regulatory T Cells (C5) AU - Jankovic, Dragana Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Lymphocytes T KW - Immunoregulation KW - Helper cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41904478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.atitle=Highly+Polarized+Th1+Cells+as+Regulatory+T+Cells&rft.au=Jankovic%2C+Dragana&rft.aulast=Jankovic&rft.aufirst=Dragana&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel NONOates to target NO in tissue T2 - 2009 Gordon Research Conference on Nitric Oxide AN - 41904274; 5115510 JF - 2009 Gordon Research Conference on Nitric Oxide AU - Keefer, Larry Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Nitric oxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41904274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.atitle=Novel+NONOates+to+target+NO+in+tissue&rft.au=Keefer%2C+Larry&rft.aulast=Keefer&rft.aufirst=Larry&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Nitric+Oxide&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=nitric LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prostatic Tumors Induce CD8+ T Cells to Become Suppressor Cells T2 - 2009 Keystone Symposia on Regulatory T Cells (C5) AN - 41903826; 5114245 JF - 2009 Keystone Symposia on Regulatory T Cells (C5) AU - Hurwitz, Andy Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Tumors KW - CD8 antigen KW - Lymphocytes T KW - Suppressor cells KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41903826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.atitle=Prostatic+Tumors+Induce+CD8%2B+T+Cells+to+Become+Suppressor+Cells&rft.au=Hurwitz%2C+Andy&rft.aulast=Hurwitz&rft.aufirst=Andy&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of TGF-beta in Induction and Survival of Treg Cells T2 - 2009 Keystone Symposia on Regulatory T Cells (C5) AN - 41890905; 5114242 JF - 2009 Keystone Symposia on Regulatory T Cells (C5) AU - Chen, Wanjun Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 KW - Survival KW - Lymphocytes T KW - Transforming growth factor-b KW - Cell survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41890905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.atitle=Role+of+TGF-beta+in+Induction+and+Survival+of+Treg+Cells&rft.au=Chen%2C+Wanjun&rft.aulast=Chen&rft.aufirst=Wanjun&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Regulatory+T+Cells+%28C5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Age stereotypes held earlier in life predict cardiovascular events in later life AN - 37255331; 3923577 JF - Psychological science AU - Levy, Becca R AU - Zonderman, Alan B AU - Slade, Martin D AU - Ferrucci, Luigi AD - Yale University ; National Institute on Aging Intramural Research Program, Baltimore Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 296 EP - 298 VL - 20 IS - 3 SN - 0956-7976, 0956-7976 KW - Sociology KW - Longitudinal studies KW - Ageing KW - Habits KW - Smoking KW - Psychology KW - Mental stress KW - Psychological factors KW - Sociological analysis KW - Tobacco KW - Heart disease KW - Stereotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37255331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+science&rft.atitle=Age+stereotypes+held+earlier+in+life+predict+cardiovascular+events+in+later+life&rft.au=Levy%2C+Becca+R%3BZonderman%2C+Alan+B%3BSlade%2C+Martin+D%3BFerrucci%2C+Luigi&rft.aulast=Levy&rft.aufirst=Becca&rft.date=2009-03-01&rft.volume=20&rft.issue=3&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=Psychological+science&rft.issn=09567976&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10401; 655; 5796 3617 6220; 12247 11814; 11755 5707 6071 1542 11325; 5707 6071 1542 11325; 12766 3055 798 10286; 7953 7954; 7541 7537 971; 11993 971; 10404 ER - TY - JOUR T1 - Practicing what they preach: health behaviors of those who provide health advice to extensive social networks AN - 37118507; 3858733 AB - As a way of identifying a conduit to disseminate health information, this study aims to explore health behaviors and attitudes of a unique group of extensively socially-networked individuals who regularly are asked for their health advice. Respondents from a population-based consumer opinion panel (n = 2,639) were categorized as "extensively socially-networked" (75+ friends and acquaintances, and almost daily giving friends advice on general issues) vs. "non-networked." The networked respondents were further divided into "health-networked" (regularly asked for health advice) versus "only-socially-networked" groups (asked for general advice, not health). Chi-square analyses, ANOVA tests, and multivariate regressions controlling for sociodemographic variables compared health behaviors and attitudes between groups. Results indicated that health-networked individuals reported more positive health behaviors (e.g., fruit and vegetable consumption) and attitudes than only-socially-networked and non-networked individuals. Future research is warranted to elucidate how providing health advice to a large network contributes to the positive health of health-networked individuals. Exploratory analyses revealed that doctors and health/fitness magazines were main sources of health and nutrition information for health-networked respondents. Through their advice and word-of-mouth, health-networked individuals have the potential to influence the health information of large groups of people and, therefore, may serve as valuable change agents to disseminate health and nutrition information. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Colon-Ramos, Uriyoan AU - Atienza, Audie AU - Weber, Deanne AU - Taylor, Melissa AU - Uy, Christina AU - Yaroch, Amy AD - National Cancer Institute ; Porter Novelli ; Discovery Communication Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 119 EP - 130 VL - 14 IS - 2 SN - 1081-0730, 1081-0730 KW - Sociology KW - Health KW - Network analysis KW - Behavioural sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37118507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Practicing+what+they+preach%3A+health+behaviors+of+those+who+provide+health+advice+to+extensive+social+networks&rft.au=Colon-Ramos%2C+Uriyoan%3BAtienza%2C+Audie%3BWeber%2C+Deanne%3BTaylor%2C+Melissa%3BUy%2C+Christina%3BYaroch%2C+Amy&rft.aulast=Colon-Ramos&rft.aufirst=Uriyoan&rft.date=2009-03-01&rft.volume=14&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730802659111 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5772; 1542 11325; 8631 971 8634 DO - http://dx.doi.org/10.1080/10810730802659111 ER - TY - JOUR T1 - Family-based association of FKBP5 in bipolar disorder AN - 221165231; 18180755 AB - The FKBP5 gene product forms part of a complex with the glucocorticoid receptor and can modulate cortisol-binding affinity. Variations in the gene have been associated with increased recurrence of depression and with rapid response to antidepressant treatment. We sought to determine whether common FKBP5 variants confer risk for bipolar disorder. We genotyped seven tag single-nucleotide polymorphisms (SNPs) in FKBP5, plus two SNPs previously associated with illness, in 317 families with 554 bipolar offspring, derived primarily from two studies. Single marker and haplotypic analyses were carried out with FBAT and EATDT employing the standard bipolar phenotype. Association analyses were also conducted using 11 disease-related variables as covariates. Under an additive genetic model, rs4713902 showed significant overtransmission of the major allele (P=0.0001), which was consistent across the two sample sets (P=0.004 and 0.006). rs7757037 showed evidence of association that was strongest under the dominant model (P=0.001). This result was consistent across the two datasets (P=0.017 and 0.019). The dominant model yielded modest evidence for association (P<0.05) for three additional markers. Covariate-based analyses suggested that genetic variation within FKBP5 may influence attempted suicide and number of depressive episodes in bipolar subjects. Our results are consistent with the well-established relationship between the hypothalamic-pituitary-adrenal (HPA) axis, which mediates the stress response through regulation of cortisol, and mood disorders. Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses. JF - Molecular Psychiatry AU - Willour, V L AU - Chen, H AU - Toolan, J AU - Belmonte, P AU - Cutler, D J AU - Goes, F S AU - Zandi, P P AU - Lee, R S AU - Mackinnon, D F AU - Mondimore, F M AU - Schweizer, B AU - Depaulo, J R, Jr AU - Gershon, E S AU - Mcmahon, F J AU - Potash, J B Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 261 EP - 8 CY - New York PB - Nature Publishing Group VL - 14 IS - 3 SN - 13594184 KW - Medical Sciences--Psychiatry And Neurology KW - Tacrolimus Binding Proteins KW - tacrolimus binding protein 5 KW - Pedigree KW - Polymorphism, Single Nucleotide KW - Haplotypes KW - Bipolar Disorder -- physiopathology KW - Hypothalamo-Hypophyseal System -- physiopathology KW - Humans KW - Pituitary-Adrenal System -- physiopathology KW - Cohort Studies KW - Mood Disorders -- physiopathology KW - Linkage Disequilibrium KW - Mood Disorders -- genetics KW - Tacrolimus Binding Proteins -- genetics KW - Bipolar Disorder -- genetics KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/221165231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Psychiatry&rft.atitle=Family-based+association+of+FKBP5+in+bipolar+disorder&rft.au=Willour%2C+V+L%3BChen%2C+H%3BToolan%2C+J%3BBelmonte%2C+P%3BCutler%2C+D+J%3BGoes%2C+F+S%3BZandi%2C+P+P%3BLee%2C+R+S%3BMackinnon%2C+D+F%3BMondimore%2C+F+M%3BSchweizer%2C+B%3BDepaulo%2C+J+R%2C+Jr%3BGershon%2C+E+S%3BMcmahon%2C+F+J%3BPotash%2C+J+B&rft.aulast=Willour&rft.aufirst=V&rft.date=2009-03-01&rft.volume=14&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Molecular+Psychiatry&rft.issn=13594184&rft_id=info:doi/10.1038%2Fsj.mp.4002141 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Mar 2009 N1 - Last updated - 2014-09-07 DO - http://dx.doi.org/10.1038/sj.mp.4002141 ER - TY - JOUR T1 - Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) Resource Announcement AN - 21313006; 12041012 AB - Abstract not available. JF - Neuroinformatics AU - Luo, Xiao-zhong James AU - Kennedy, David N AU - Cohen, Zohara AD - National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA, luoja@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 55 EP - 56 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 7 IS - 1 SN - 1539-2791, 1539-2791 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neuroimaging KW - Informatics KW - Bioinformatics KW - W 30965:Miscellaneous, Reviews KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21313006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroinformatics&rft.atitle=Neuroimaging+Informatics+Tools+and+Resources+Clearinghouse+%28NITRC%29+Resource+Announcement&rft.au=Luo%2C+Xiao-zhong+James%3BKennedy%2C+David+N%3BCohen%2C+Zohara&rft.aulast=Luo&rft.aufirst=Xiao-zhong&rft.date=2009-03-01&rft.volume=7&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Neuroinformatics&rft.issn=15392791&rft_id=info:doi/10.1007%2Fs12021-008-9036-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Informatics; Bioinformatics DO - http://dx.doi.org/10.1007/s12021-008-9036-8 ER - TY - JOUR T1 - Comparative Structural and Molecular Characterization of Ribitol-5-Phosphate-Containing Streptococcus oralis Coaggregation Receptor Polysaccharides , AN - 21304100; 11916477 AB - The antigenically related coaggregation receptor polysaccharides (RPS) of Streptococcus oralis strains C104 and SK144 mediate recognition of these bacteria by other members of the dental plaque biofilm community. In the present study, the structure of strain SK144 RPS was established by high resolution NMR spectroscopy as [6Galf?1-6GalNAc?1-3Gal1-2ribitol-5-PO4--6Galf?1-3Gal?1]n, thereby indicating that this polysaccharide and the previously characterized RPS of strain C104 are identical, except for the linkage between Gal and ribitol-5-phosphate, which is 1-2 in strain SK144 versus 1-1 in strain C104. Studies to define the molecular basis of RPS structure revealed comparable genes for six putative transferases and a polymerase in the rps loci of these streptococci. Cell surface RPS production was abolished by disrupting the gene for the first transferase of strain C104 with a nonpolar erm cassette. It was restored in the resulting mutant by plasmid-based expression of either wcjG, the corresponding gene of S. pneumoniae for serotype 10A capsular polysaccharide (CPS) biosynthesis or wbaP for the transferase of Salmonella enterica that initiates O-polysaccharide biosynthesis. Thus, WcjG, like WbaP, appears to initiate polysaccharide biosynthesis by transferring galactose-1-phosphate to a lipid carrier. In further studies, the structure of strain C104 RPS was converted to that of strain SK144 by replacing the gene (wefM) for the fourth transferase in the rps locus of strain C104 with the corresponding gene (wcrC) of strain SK144 or Streptococcus pneumoniae serotype 10A. These findings identify genetic markers for the different ribitol-5-phosphate-containing types of RPS present in S. oralis and establish a close relationship between these polysaccharides and serogroup 10 CPSs of S. pneumoniae. JF - Journal of Bacteriology AU - Yang, Jinghua AU - Ritchey, Mary AU - Yoshida, Yasuo AU - Bush, CAllen AU - Cisar, John O AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda Maryland 20892, john.cisar@nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 1891 EP - 1900 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 6 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Cell surface KW - Streptococcus pneumoniae KW - Serotypes KW - Salmonella enterica KW - Lipids KW - Magnetic resonance spectroscopy KW - Genetic markers KW - Biofilms KW - Dental plaque KW - Capsular polysaccharides KW - Streptococcus oralis KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21304100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Comparative+Structural+and+Molecular+Characterization+of+Ribitol-5-Phosphate-Containing+Streptococcus+oralis+Coaggregation+Receptor+Polysaccharides+%2C&rft.au=Yang%2C+Jinghua%3BRitchey%2C+Mary%3BYoshida%2C+Yasuo%3BBush%2C+CAllen%3BCisar%2C+John+O&rft.aulast=Yang&rft.aufirst=Jinghua&rft.date=2009-03-01&rft.volume=191&rft.issue=6&rft.spage=1891&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01532-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 37 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Cell surface; Serotypes; Magnetic resonance spectroscopy; Lipids; Genetic markers; Biofilms; Dental plaque; Capsular polysaccharides; Streptococcus pneumoniae; Salmonella enterica; Streptococcus oralis DO - http://dx.doi.org/10.1128/JB.01532-08 ER - TY - JOUR T1 - GRL-02031, a Novel Nonpeptidic Protease Inhibitor (PI) Containing a Stereochemically Defined Fused Cyclopentanyltetrahydrofuran Potent against Multi-PI-Resistant Human Immunodeficiency Virus Type 1 In Vitro AN - 21272907; 11811195 AB - We generated a novel nonpeptidic protease inhibitor (PI), GRL-02031, by incorporating a stereochemically defined fused cyclopentanyltetrahydrofuran (Cp-THF) which exerted potent activity against a wide spectrum of human immunodeficiency virus type 1 (HIV-1) isolates, including multidrug-resistant HIV-1 variants. GRL-02031 was highly potent against laboratory HIV-1 strains and primary clinical isolates, including subtypes A, B, C, and E (50% effective concentration [EC50] range, 0.015 to 0.038 mu M), with minimal cytotoxicity (50% cytotoxic concentration, >100 mu M in CD4+ MT-2 cells), although it was less active against two HIV-2 strains (HIV-2EHO and HIV-2ROD) (EC50, 0.60 mu M) than against HIV-1 strains. GRL-02031 at relatively low concentrations blocked the infection and replication of each of the HIV-1NL4-3 variants exposed to and selected by up to 5 mu M of saquinavir, amprenavir, indinavir, nelfinavir, or ritonavir and 1 mu M of lopinavir or atazanavir (EC50 range, 0.036 to 0.14 mu M). GRL-02031 was also potent against multi-PI-resistant clinical HIV-1 variants isolated from patients who had no response to the conventional antiretroviral regimens that then existed, with EC50s ranging from 0.014 to 0.042 mu M (changes in the EC50s were less than twofold the EC50 for wild-type HIV-1). Upon selection of HIV-1NL4-3 in the presence of GRL-02031, mutants carrying L10F, L33F, M46I, I47V, Q58E, V82I, I84V, and I85V in the protease-encoding region and G62R (within p17), L363M (p24-p2 cleavage site), R409K (within p7), and I437T (p7-p1 cleavage site) in the gag-encoding region emerged. GRL-02031 was potent against a variety of HIV-1NL4-3-based molecular infectious clones containing a single primary mutation reported previously or a combination of such mutations, although it was slightly less active against HIV-1 variants containing consecutive amino acid substitutions: M46I and I47V or I84V and I85V. Structural modeling analysis demonstrated a distinct bimodal binding of GRL-02031 to protease, which may provide advantages to GRL-02031 in blocking the replication of a wide spectrum of HIV-1 variants resistant to PIs and in delaying the development of resistance of HIV-1 to GRL-02031. The present data warrant the further development of GRL-02031 as a potential therapeutic agent for the treatment of infections with primary and multidrug-resistant HIV-1 variants. JF - Antimicrobial Agents & Chemotherapy AU - Koh, Yasuhiro AU - Das, Debananda AU - Leschenko, Sofiya AU - Nakata, Hirotomo AU - Ogata-Aoki, Hiromi AU - Amano, Masayuki AU - Nakayama, Maki AU - Ghosh, Arun K AU - Mitsuya, Hiroaki AD - Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto 860-8556, Japan, hmitsuya@helix.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 997 EP - 1006 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 53 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Amino acid substitution KW - Indinavir KW - CD4 antigen KW - Lopinavir KW - Proteinase KW - Nelfinavir KW - Clinical isolates KW - Replication KW - Mutation KW - Saquinavir KW - Drug resistance KW - Infection KW - Antiviral agents KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - amprenavir KW - Data processing KW - Proteinase inhibitors KW - Cytotoxicity KW - Ritonavir KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21272907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=GRL-02031%2C+a+Novel+Nonpeptidic+Protease+Inhibitor+%28PI%29+Containing+a+Stereochemically+Defined+Fused+Cyclopentanyltetrahydrofuran+Potent+against+Multi-PI-Resistant+Human+Immunodeficiency+Virus+Type+1+In+Vitro&rft.au=Koh%2C+Yasuhiro%3BDas%2C+Debananda%3BLeschenko%2C+Sofiya%3BNakata%2C+Hirotomo%3BOgata-Aoki%2C+Hiromi%3BAmano%2C+Masayuki%3BNakayama%2C+Maki%3BGhosh%2C+Arun+K%3BMitsuya%2C+Hiroaki&rft.aulast=Koh&rft.aufirst=Yasuhiro&rft.date=2009-03-01&rft.volume=53&rft.issue=3&rft.spage=997&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00689-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; Human immunodeficiency virus 2; Infection; Drug resistance; Replication; Proteinase inhibitors; Cytotoxicity; Mutation; CD4 antigen; Lopinavir; Nelfinavir; Clinical isolates; Indinavir; Amino acid substitution; Ritonavir; Proteinase; Data processing; Saquinavir; Antiviral agents; amprenavir DO - http://dx.doi.org/10.1128/AAC.00689-08 ER - TY - JOUR T1 - Structure and Dynamics of Male Swarms of Anopheles gambiae AN - 21184932; 11588577 AB - Mosquito swarms are poorly understood mating aggregations. In the malaria vector Anopheles gambiae Giles, they are known to depend on environmental conditions, such as the presence of a marker on the ground, and they may be highly relevant to reproductive isolation. We present quantitative measurements of in dividual An. gambiae positions within swarms from Doneguebougou, Mali, estimated by stereoscopic video image analysis. Results indicate that swarms in this species are approximately spherical, with an unexpectedly high density of individuals close to the swarm centroid. This high density may be the result of individual males maximizing their probability of encountering afemale or aproduct of mosquito orientation through cues within the swarm. Our analysis also suggests a difference in swarm organization between putative incipient species of An. gambiae with increasing numbers of males. This may be related to a difference in marker use between these groups, supporting the hypothesis that swarming behavior is a mechanism of mate recognition and ultimately reproductive isolation. JF - Journal of Medical Entomology AU - Manoukis, Nicholas C AU - Diabate, Abdoulaye AU - Abdoulaye, Adamou AU - Diallo, Moussa AU - Dao, Adama AU - Yaro, Alpha S AU - Ribeiro, Jose MC AU - Lehmann, Tovi Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 227 EP - 235 PB - Entomological Society of America, 9301 Annapolis Rd. Lanham MD 20706 USA VL - 46 IS - 2 SN - 0022-2585, 0022-2585 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Entomology Abstracts KW - Anopheles gambiae KW - swarm KW - mate recognition KW - three-dimensional localization KW - stereoscopic image analysis KW - Human diseases KW - Mali KW - Males KW - Population density KW - Vectors KW - Image processing KW - Malaria KW - Hosts KW - Mate recognition KW - Orientation behaviour KW - Public health KW - Mating KW - Swarms KW - Reproductive isolation KW - Swarming behavior KW - Reproductive behaviour KW - Environmental conditions KW - Aquatic insects KW - K 03410:Animal Diseases KW - Q1 08461:Plankton KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21184932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Entomology&rft.atitle=Structure+and+Dynamics+of+Male+Swarms+of+Anopheles+gambiae&rft.au=Manoukis%2C+Nicholas+C%3BDiabate%2C+Abdoulaye%3BAbdoulaye%2C+Adamou%3BDiallo%2C+Moussa%3BDao%2C+Adama%3BYaro%2C+Alpha+S%3BRibeiro%2C+Jose+MC%3BLehmann%2C+Tovi&rft.aulast=Manoukis&rft.aufirst=Nicholas&rft.date=2009-03-01&rft.volume=46&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Entomology&rft.issn=00222585&rft_id=info:doi/10.1603%2F033.046.0207 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Human diseases; Males; Population density; Reproductive behaviour; Hosts; Environmental conditions; Aquatic insects; Orientation behaviour; Public health; Mating; Reproductive isolation; Swarms; Swarming behavior; Image processing; Vectors; Malaria; Mate recognition; Anopheles gambiae; Mali DO - http://dx.doi.org/10.1603/033.046.0207 ER - TY - JOUR T1 - Tuberculosis and subsequent risk of lung cancer in Xuanwei, China AN - 20747971; 9356159 AB - Tobacco and indoor air pollution from smoky coal are major causes of lung cancer in rural Xuanwei County, China. Tuberculosis has been suggested to increase lung cancer risk, but data from prior studies are limited. We conducted an analysis of data from a retrospective cohort study of 42,422 farmers in Xuanwei. In 1992, interviewers administered a standardized questionnaire that included lifetime medical history, including tuberculosis. Subjects were followed from 1976, with deaths from lung cancer ascertained through 1996. We used proportional hazards regression to assess the association between tuberculosis and subsequent lung cancer mortality. Tuberculosis was reported by 246 subjects (0.6%), and 2,459 (5.8%) died from lung cancer during follow-up. Lung cancer mortality was substantially higher in subjects with tuberculosis than in those without (25 vs. 3.1 per 1,000 person-years). The association was especially pronounced in the first 5 years after tuberculosis diagnosis (hazard ratios [HRs] ranging 6.7-13) but remained strong 5-9.9 years (HR 3.4, 95% CI 1.3-9.1) and 10+ years (HR 3.0, 95% CI 1.3-7.3) after tuberculosis. These associations were similar among men and women and among smoky coal users (70.5% of subjects). Adjustment for demographic characteristics, lung disease and tobacco use did not affect results. In Xuanwei, China, tuberculosis is an important risk factor for lung cancer. The increased lung cancer risk, persisting years after a tuberculosis diagnosis, could reflect the effects of chronic pulmonary inflammation and scarring arising from tuberculosis. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Engels, Eric A AU - Shen, Min AU - Chapman, Robert S AU - Pfeiffer, Ruth M AU - Yu, Ying-Ying AU - He, Xingzhou AU - Lan, Qing AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, engelse@exchange.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 1183 EP - 1187 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 5 SN - 0020-7136, 0020-7136 KW - Microbiology Abstracts B: Bacteriology; Pollution Abstracts; Risk Abstracts KW - demography KW - Historical account KW - Mycobacterium KW - Indoor air pollution KW - Coal KW - Demography KW - Risk factors KW - Tobacco KW - Tuberculosis KW - Lung cancer KW - Mortality KW - Inventories KW - Data processing KW - Lung diseases KW - Cancer KW - Inflammation KW - tuberculosis KW - Air pollution KW - Standards KW - China, People's Rep. KW - Rural areas KW - P 0000:AIR POLLUTION KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20747971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Tuberculosis+and+subsequent+risk+of+lung+cancer+in+Xuanwei%2C+China&rft.au=Engels%2C+Eric+A%3BShen%2C+Min%3BChapman%2C+Robert+S%3BPfeiffer%2C+Ruth+M%3BYu%2C+Ying-Ying%3BHe%2C+Xingzhou%3BLan%2C+Qing&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2009-03-01&rft.volume=124&rft.issue=5&rft.spage=1183&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Demography; Air pollution; Inventories; Mortality; Data processing; Risk factors; Lung diseases; Tobacco; Tuberculosis; Coal; Inflammation; Lung cancer; demography; tuberculosis; Historical account; Indoor air pollution; Standards; Cancer; Rural areas; Mycobacterium; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.24042 ER - TY - JOUR T1 - The Vulnerability of the Very Sick AN - 20747278; 9194911 AB - When seriously ill patients for whom existing treatments are inadequate are invited to participate in clinical trials that offer a new treatment, should those persons be considered 'vulnerable'? And if so, what additional protections should they be accorded? This article attempts to provide some answers. JF - Journal of Law, Medicine & Ethics AU - Menikoff, Jerry AD - 1Director of the Office of Human Subjects Research at the National Institutes of Health. Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 51 EP - 58 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 37 IS - 1 SN - 1073-1105, 1073-1105 KW - Risk Abstracts KW - Ethics KW - vulnerability KW - clinical trials KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20747278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Law%2C+Medicine+%26+Ethics&rft.atitle=The+Vulnerability+of+the+Very+Sick&rft.au=Menikoff%2C+Jerry&rft.aulast=Menikoff&rft.aufirst=Jerry&rft.date=2009-03-01&rft.volume=37&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+Law%2C+Medicine+%26+Ethics&rft.issn=10731105&rft_id=info:doi/10.1111%2Fj.1748-720X.2009.00350.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Ethics; vulnerability; clinical trials DO - http://dx.doi.org/10.1111/j.1748-720X.2009.00350.x ER - TY - JOUR T1 - Assessing anaphylactic risk? Consider mast cell clonality AN - 20739288; 9163606 AB - Background: Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic to these insects. Objective The incidence of clonal mast cell (MC) disorders in subjects with both systemic reactions to Hymenoptera stings and increased serum baseline tryptase (sBT) levels was assessed by using bone marrow (BM) aspirates and biopsy specimens. Methods Subjects with a history of a systemic reaction caused by a Hymenoptera sting underwent the standard diagnostic work-up for Hymenoptera allergy, and sBT levels were measured. Subjects with an increased sBT level had BM evaluation that included histology/cytology, flow cytometry, and detection of KIT mutations. Results Forty-four (11.6%) of 379 subjects with systemic reactions had increased sBT levels (>11.4 ng/mL), and 31 (70.5%) of these had a history of anaphylaxis. Thirty-four subjects with increased sBT levels underwent a BM analysis. Histology detected diagnostic or subdiagnostic MC infiltrates in 22 (65%) of 34 patients. Abnormal MCs were identified by means of flow cytometry and cytology in 26 (78.8%) of 33 and 20 (58.8%) of 34 subjects, respectively. A KIT mutation was detected in 17 (54.8%) of 31 subjects. The diagnosis was indolent systemic mastocytosis in 21 (61.7%) of 34 subjects and monoclonal MC activation syndrome in 9 (26.5%) of 34 subjects. All subjects with anaphylaxis had one of those 2 disorders. Conclusion The concomitant presence of systemic reactions (especially anaphylaxis) after Hymenoptera stings and increased sBT levels strongly suggests that a BM examination is indicated for the diagnosis of clonal MC disease. JF - Journal of Allergy and Clinical Immunology AU - Metcalfe, Dean D AU - Schwartz, Lawrence B AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md, dmetcalfe@niaid.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 687 EP - 688 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA, [mailto:membership@aaaai.org], [URL:http://www.aaai.org] VL - 123 IS - 3 SN - 0091-6749, 0091-6749 KW - Entomology Abstracts; Risk Abstracts; Immunology Abstracts KW - Anaphylaxis KW - tryptase KW - mast cells KW - KIT KW - venom KW - Historical account KW - Stings KW - Data processing KW - Immunology KW - Bone marrow KW - Mast cells KW - Biopsy KW - Tryptase KW - insects KW - Allergies KW - Flow cytometry KW - Hypersensitivity KW - Histology KW - Mastocytosis KW - Hymenoptera KW - Mutation KW - Z 05300:General KW - F 06925:Hypersensitivity KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20739288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Assessing+anaphylactic+risk%3F+Consider+mast+cell+clonality&rft.au=Metcalfe%2C+Dean+D%3BSchwartz%2C+Lawrence+B&rft.aulast=Metcalfe&rft.aufirst=Dean&rft.date=2009-03-01&rft.volume=123&rft.issue=3&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2009.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Hypersensitivity; Data processing; Stings; Anaphylaxis; Bone marrow; Mast cells; Mastocytosis; Biopsy; Tryptase; Mutation; Historical account; Histology; Immunology; insects; Allergies; Hymenoptera DO - http://dx.doi.org/10.1016/j.jaci.2009.02.003 ER - TY - JOUR T1 - Heterocyclic aromatic amine pesticide use and human cancer risk: Results from the U.S. Agricultural Health Study AN - 20629553; 9356163 AB - Imazethapyr, a heterocyclic aromatic amine, is a widely used crop herbicide first registered for use in the United States in 1989. We evaluated cancer incidence among imazethapyr-exposed pesticide applicators enrolled in the Agricultural Health Study (AHS). The AHS is a prospective cohort of 57,311 licensed pesticide applicators in the U.S., enrolled from 1993-1997. Among the 49,398 licensed pesticide applicators eligible for analysis, 20,646 applicators reported use of imazethapyr and 2,907 incident cancers developed through 2004. Imazethapyr exposure was classified by intensity-weighted lifetime exposure days calculated as [years of use X days per year X intensity level]. Poisson regression analysis was used to evaluate the relationship between imazethapyr exposure and cancer incidence. We found significant trends in risk with increasing lifetime exposure for bladder cancer (p for trend 0.01) and colon cancer (p for trend 0.02). Rate ratios (RRs) were increased by 137% for bladder cancer and 78% for colon cancer when the highest exposed were compared to the nonexposed. The excess risk for colon cancer was limited to proximal cancers, (RR = 2.73, 95% confidence intervals 1.42, 5.25, p for trend 0.001). No association was observed for prostate, lung, rectum, kidney, oral, pancreas, lymphohematopoietic cancers or melanoma. These findings provide new evidence that exposure to aromatic amine pesticides may be an overlooked exposure in the etiology of bladder and colon cancer. The use of imazethapyr and other imidazolinone compounds should continue to be evaluated for potential risk to humans. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Koutros, Stella AU - Lynch, Charles F AU - Ma, Xiaomei AU - Lee, Won Jin AU - Hoppin, Jane A AU - Christensen, Carol H AU - Andreotti, Gabriella AU - Freeman, Laura Beane AU - Rusiecki, Jennifer A AU - Hou, Lifang AU - Sandler, Dale P AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, KoutrosS@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 1206 EP - 1212 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 5 SN - 0020-7136, 0020-7136 KW - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - Pancreas KW - Crops KW - Pancreatic cancer KW - Colon cancer KW - Amines KW - Prostate KW - Aromatics KW - Rectum KW - Melanoma KW - urinary bladder KW - amines KW - Regression analysis KW - Imidazolinones KW - Etiology KW - Urinary bladder KW - Herbicides KW - melanoma KW - Cancer KW - USA KW - Lung KW - Pesticides KW - Kidney KW - H 5000:Pesticides KW - R2 23060:Medical and environmental health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20629553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Heterocyclic+aromatic+amine+pesticide+use+and+human+cancer+risk%3A+Results+from+the+U.S.+Agricultural+Health+Study&rft.au=Koutros%2C+Stella%3BLynch%2C+Charles+F%3BMa%2C+Xiaomei%3BLee%2C+Won+Jin%3BHoppin%2C+Jane+A%3BChristensen%2C+Carol+H%3BAndreotti%2C+Gabriella%3BFreeman%2C+Laura+Beane%3BRusiecki%2C+Jennifer+A%3BHou%2C+Lifang%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+C+R&rft.aulast=Koutros&rft.aufirst=Stella&rft.date=2009-03-01&rft.volume=124&rft.issue=5&rft.spage=1206&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Cancer; Pesticides; Amines; urinary bladder; melanoma; Kidney; Crops; Herbicides; Lung; Etiology; Urinary bladder; Melanoma; Colon cancer; Aromatics; amines; Rectum; Imidazolinones; Prostate; Regression analysis; Pancreatic cancer; Pancreas DO - http://dx.doi.org/10.1002/ijc.24020 ER - TY - JOUR T1 - Structural Basis for Binding of RNA and Cofactor by a KsgA Methyltransferase AN - 20601910; 9302081 AB - Among methyltransferases, KsgA and the reaction it catalyzes are conserved throughout evolution. However, the specifics of substrate recognition by the enzyme remain unknown. Here we report structures of Aquifex aeolicus KsgA, in its ligand-free form, in complex with RNA, and in complex with both RNA and S-adenosylhomocysteine (SAH, reaction product of cofactor S-adenosylmethionine), revealing critical structural information on KsgA-RNA and KsgA-SAH interactions. Moreover, the structures show how conformational changes that occur upon RNA binding create the cofactor-binding site. There are nine conserved functional motifs (motifs I-VIII and X) in KsgA. Prior to RNA binding, motifs I and VIII are flexible, each exhibiting two distinct conformations. Upon RNA binding, the two motifs become stabilized in one of these conformations, which is compatible with the binding of SAH. Motif X, which is also stabilized upon RNA binding, is directly involved in the binding of SAH. JF - Structure AU - Tu, Chao AU - Tropea, Joseph E AU - Austin, Brian P AU - Court, Donald L AU - Waugh, David S AU - Ji, Xinhua AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA, jix@ncifcrf.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 374 EP - 385 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 17 IS - 3 SN - 0969-2126, 0969-2126 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - PROTEINS KW - RNA KW - Cofactors KW - Methyltransferase KW - Aquifex aeolicus KW - Enzymes KW - S-Adenosylmethionine KW - Evolution KW - Conformation KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20601910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure&rft.atitle=Structural+Basis+for+Binding+of+RNA+and+Cofactor+by+a+KsgA+Methyltransferase&rft.au=Tu%2C+Chao%3BTropea%2C+Joseph+E%3BAustin%2C+Brian+P%3BCourt%2C+Donald+L%3BWaugh%2C+David+S%3BJi%2C+Xinhua&rft.aulast=Tu&rft.aufirst=Chao&rft.date=2009-03-01&rft.volume=17&rft.issue=3&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Structure&rft.issn=09692126&rft_id=info:doi/10.1016%2Fj.str.2009.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Methyltransferase; Cofactors; RNA; Enzymes; S-Adenosylmethionine; Evolution; Conformation; Aquifex aeolicus DO - http://dx.doi.org/10.1016/j.str.2009.01.010 ER - TY - JOUR T1 - Conditioning in 2 2 Tables AN - 20557355; 9256741 AB - Summary.Two-by-two tables arise in a number of diverse settings in biomedical research, including analysis of data from a clinical trial with a binary outcome and gating methods in flow cytometry to separate antigen-specific immune responses from general immune responses. These applications offer interesting challenges concerning what we should really be conditioning on-the total number of events, the number of events in the control condition, etc. We give several biostatistics examples to illustrate the complexities of analyzing what appear to be simple data. JF - Biometrics AU - Proschan, Michael A AU - Nason, Martha AD - Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive, MSC 7609, Bethesda, Maryland 20892-7609, U.S.A., ProschaM@niaid.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 316 EP - 322 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 65 IS - 1 SN - 0006-341X, 0006-341X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Adaptive sample size KW - Conditional inference KW - Contingency table KW - Fisher's exact test KW - Nuisance parameter KW - Test of proportions KW - Flow cytometry KW - Data processing KW - Gating KW - Biometrics KW - Clinical trials KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20557355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Conditioning+in+2+2+Tables&rft.au=Proschan%2C+Michael+A%3BNason%2C+Martha&rft.aulast=Proschan&rft.aufirst=Michael&rft.date=2009-03-01&rft.volume=65&rft.issue=1&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/10.1111%2Fj.1541-0420.2008.01053.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Data processing; Gating; Biometrics; Clinical trials DO - http://dx.doi.org/10.1111/j.1541-0420.2008.01053.x ER - TY - JOUR T1 - Noninvasive monitoring of a murine model of metastatic pheochromocytoma: A comparison of contrast-enhanced microCT and nonenhanced MRI AN - 20555132; 9260215 AB - Purpose To compare contrast-enhanced micro-computed tomography (microCT) and nonenhanced respiratory-triggered magnetic resonance imaging (MRI) in an animal model of metastatic pheochromocytoma. Animal models are becoming important in the study of cancer treatment and imaging is useful in minimizing the number of animals needed and reducing costs associated with autopsies. However, the choice of imaging modality is still evolving. Materials and Methods Adult female nude mice were injected by tail vein with a mouse pheochromocytoma (MPC) cell line (MPC 4/30PRR) to create a metastatic model. After optimizing imaging techniques, eight mice were imaged with both respiratory triggered MRI and microCT and the findings were verified histologically. Results MicroCT and MRI were approximately equal in their ability to detect hepatic metastases at a size threshold of 350 m. In the lungs, MRI was more sensitive than microCT, detecting lesions 0.6 mm in diameter versus 1 mm for microCT. Additionally, MRI was more sensitive for lesions in the kidneys, bone, ovaries, and adrenal glands. MRI demonstrated a higher contrast-to-noise ratio (CNR) than microCT. Conclusion In addition to the advantage of not exposing the animal to ionizing radiation, MRI provided a more complete assessment of the extent of metastases in this model compared to microCT. JF - Journal of Magnetic Resonance Imaging AU - Martiniova, Lucia AU - Kotys, Melanie S AU - Thomasson, David AU - Schimel, Daniel AU - Lai, Edwin W AU - Bernardo, Marcelino AU - Merino, Maria J AU - Powers, James F AU - Ruzicka, Jan AU - Kvetnansky, Richard AU - Choyke, Peter L AU - Pacak, Karel AD - Reproductive and Adult Endocrinology Program, National Institutes of Child Health and Human Development, Bethesda, Maryland, karel@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 685 EP - 691 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 29 IS - 3 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - Adrenal glands KW - Autopsy KW - Magnetic resonance imaging KW - Animal models KW - Cancer KW - Pheochromocytoma KW - Metastases KW - Veins KW - Lung KW - Ionizing radiation KW - Computed tomography KW - Liver KW - Kidney KW - Ovaries KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20555132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Noninvasive+monitoring+of+a+murine+model+of+metastatic+pheochromocytoma%3A+A+comparison+of+contrast-enhanced+microCT+and+nonenhanced+MRI&rft.au=Martiniova%2C+Lucia%3BKotys%2C+Melanie+S%3BThomasson%2C+David%3BSchimel%2C+Daniel%3BLai%2C+Edwin+W%3BBernardo%2C+Marcelino%3BMerino%2C+Maria+J%3BPowers%2C+James+F%3BRuzicka%2C+Jan%3BKvetnansky%2C+Richard%3BChoyke%2C+Peter+L%3BPacak%2C+Karel&rft.aulast=Martiniova&rft.aufirst=Lucia&rft.date=2009-03-01&rft.volume=29&rft.issue=3&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.21654 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Adrenal glands; Autopsy; Magnetic resonance imaging; Animal models; Pheochromocytoma; Cancer; Metastases; Veins; Lung; Ionizing radiation; Computed tomography; Kidney; Liver; Ovaries DO - http://dx.doi.org/10.1002/jmri.21654 ER - TY - JOUR T1 - Anti-Inflammatory and Anti-Allergy Drugs in Rhinosinusitis AN - 20543572; 9222527 AB - Rhinosinusitis constitutes one of the most common respiratory tract diseases affecting up to 15% of the adult population in the Western world. Sinusitis is almost always accompained by inflammation of the contiguous nasal mucosa, thus the correct terminology is now rhinosinusitis. It can be classified into acute and chronic form by duration, or into acute bacterial rhinosinusitis or viral rhinosinusitis, by symptoms. This paper describes some aspects about epidemiology, pathophysiology, and predisposing factors in rhinosinusitis and nasal polyps, offering evidence based recommendations on diagnosis and first line and second line treatment. The medical management of rhinosinusitis is related to the duration and severity of symptoms and a variety of general and topical pharmacologic interventions are available, for eliminating causative factors and controlling the inflammatory and infectious components. The Authors make a review of the literature to describe the most useful anti-allergy and antiinflammatory drugs in the management of rhinosinusitis. Immunotoxins are molecules that contain a protein toxin and a ligand that is either an antibody or a growth factor. The ligand binds to a target cell antigen, and the target cell internalizes the immunotoxin, allowing the toxin to migrate to the cytoplasm where it can kill the cell. In the case of recombinant immunotoxins, the ligand and toxin are encoded in DNA that is then expressed in bacteria, and the purified immunotoxin contains the ligand and toxin fused together. Among the most active recombinant immunotoxins clinically tested are those that are targeted to hematologic malignancies. One agent, containing human interleukin-2 and truncated diphtheria toxin (denileukin diftitox), has been approved for use in cutaneous T-cell lymphoma, and has shown activity in other hematologic malignancies, including leukemias and lymphomas. Diphtheria toxin has also been targeted by other ligands, including granulocyte-macrophage colony-stimulating factor and interleukin-3, to target myelogenous leukemia cells. Single-chain antibodies containing variable heavy and light antibody domains have been fused to truncated Pseudomonas exotoxin to target lymphomas and lymphocytic leukemias. Recombinant immunotoxins anti-Tac(Fv)-PE38 (LMB-2), targeting CD25, and RFB4(dsFv)-PE38 (BL22, CAT-3888), targeting CD22, have each been tested in patients. Major responses have been observed after failure of standard chemotherapy. The most successful application of recombinant immunotoxins today is in hairy cell leukemia, where BL22 has induced complete remissions in most patients who were previously treated with optimal chemotherapy. MicroRNAs (miRNAs) are non-protein-coding small RNA molecules that negatively regulate target messenger RNA through degradation or suppression of protein translation. MiRNAs play important roles in the control of many biologic processes, such as development, differentiation, proliferation, and apoptosis. Increasing evidence shows that aberrant miRNA expression profiles and unique miRNA signaling pathways are present in a variety of cancers. MiRNAs function as oncogenes or tumor suppressors during tumor development and progression. Experimental evidence demonstrates that correction of specific miRNA alterations using miRNA mimics or antagomirs can normalize the gene regulatory network and signaling pathways, and reverse the phenotype in cancerous cells. MiRNA-based gene therapy provides an attractive anti-tumor approach for integrated cancer therapy. In this review, we focus on miRNA-based treatment for cancers, summarize the delivery systems used in experimental and preclinical research, such as liposomes, viral vectors, and nanoparticles, and consider the safety and toxicity of miRNA therapy. Malignant gliomas represent one of the most aggressive forms of brain cancer. Recent advances in the understanding of the deregulated molecular pathways of gliomas have brought about targeted therapies that have the ability to increase therapeutic efficacy in tumors while decreasing toxicity. Multi-targeted kinase inhibitors, novel monoclonal antibodies, and new vaccines have been developed. Standard treatments and current development of new therapies for malignant gliomas are reviewed, focusing specifically on growth factors and their receptors (e.g. epidermal growth factor receptor, vascular endothelial growth factor receptor, and platelet-derived growth factor receptor), as well as the intracellular effector molecules that are downstream of these growth factors (e.g. Ras/Raf/mitogen-activated protein kinase, phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin, and protein kinase C). The efficacies of other novel targeted inhibitors such as deacetylase inhibitors and heat shock protein 90 inhibitors in the treatment of gliomas are also discussed, as well as new combination therapies. In order for new agents to increase treatment efficacy, new targets need to be developed, drug delivery efficiency needs to be improved, and new biomarkers need to be discovered. All of these goals can be accomplished with time through innovative experimental designs. Background Human follicle-stimulating hormone (hFSH; follitropin alfa) can be employed therapeutically to induce ovarian follicular development in assisted reproduction treatments. Current recombinant hFSH (r-hFSH) preparations available for clinical use are labeled either in terms of the bioactivity expressed in international units (IU) or in mass ( is a subset of g). Several clinical trials have tried to assess the clinical implications of the physicochemical improvements in the dosing of follitropin alfa filled by mass (FbM). The aim of this study was to perform a meta-analysis of previous studies in order to assess the efficacy and safety of ovarian stimulation using follitropin alfa FbM compared with follitropin alfa filled by international units (FbIU). Methods A literature search was carried out in scientific databases to find published articles and abstracts comparing both hormone preparations. A fixed effects model meta-analysis was performed. The variables studied include the average dose (IU), days of treatment, estradiol peak, follicles >14mm, number of extracted oocytes, number of embryos obtained, number of cases of ovarian hyperstimulation syndrome (OHSS), and clinical pregnancies. Results A total of six studies met the stated criteria and were included in the meta-analysis. In these studies, the average r-hFSH dose per patient was 230.29IU less with administration of follitropin alfa FbM compared with FbIU, and the number of days of treatment was reduced by 0.48. In addition, a significantly greater number of oocytes (0.84) were extracted, more embryos (0.88) were obtained, and a higher peak level of estradiol (613.08pmol/L) was achieved in the patients undergoing ovarian stimulation with follitropin alfa FbM. However, no statistically significant differences were observed in the number of follicles >14mm, clinical pregnancies, or OHSS cases. Conclusion Follitropin alfa FbM, a technologically modified formulation of r-hFSH, is as safe as follitropin alfa FbIU but requires a smaller dose over a shorter period to produce more oocytes and final embryos. Objective Filgrastim XM02 is a biosimilar non-glycosylated recombinant methionyl form of human granulocyte colony-stimulating factor (r-MetHuG-CSF) expressed in Escherichia coli for subcutaneous and intravenous administration in the treatment of different forms of neutropenia and stem cell mobilization. This study was conducted to compare the pharmacokinetic and pharmacodynamic characteristics of the new biosimilar filgrastim XM02 with the marketed filgrastim (Neupogen(r)). Methods Two filgrastim doses (5 and 10 is a subset of g/kg) of the new biosimilar filgrastim XM02 and the marketed filgrastim were administered either as intravenous infusion or subcutaneous injection in four single-dose, crossover, randomized substudies, conducted in 36 subjects each. Serum concentrations of filgrastim were determined using an enzyme-linked immunosorbent assay test kit on samples taken at intervals up to 48 hours after administration. The CD34+ stem cell count up to 15 days after administration was determined by flow cytometry using a validated CD34+ cell enumeration kit, and the absolute neutrophil count (ANC) up to 96 hours after dosing was determined by the Beckman Coulter AcT differential automated hematology analyzer. The primary pharmacokinetic endpoint was the AUC48h (area under the serum concentration-time curve) of filgrastim serum concentration determined by the linear trapezoidal rule. Equivalence (biosimilarity) between the two filgrastim products was assessed by 90% confidence limits obtained from analyses of variance of log-transformed pharmacokinetic and pharmacodynamic endpoints, applying 80-125% equivalence intervals. Results The mean serum concentration profiles of filgrastim, ANC and CD34+ cells over time were similar for the two filgrastims. The 90% confidence intervals for all test/reference ratios for pharmacokinetic and pharmacodynamic endpoints lay within the accepted bioequivalence range of 80-125%. Both filgrastims showed similar safety profiles and were well tolerated. Conclusions Equivalence of the two filgrastims was clearly demonstrated for all four dose/route of administration groups. Equivalence could be demonstrated for the serum concentration profile, for the ANC profile and, even more importantly, for the CD34+ cell count, which is a marker for the ability of the granulocyte colony-stimulating factor to mobilize stem cells. ▴ Ustekinumab is a fully human monoclonal antibody that binds with high specificity and affinity to the cytokines interleukin (IL)-12 and IL-23, thereby suppressing IL-12- and IL-23-mediated inflammation associated with psoriasis. ▴ In two large, phase III trials in patients with moderate to severe plaque psoriasis, significantly more subcutaneous ustekinumab 45 or 90mg recipients (administered as two injections 4 weeks apart) than placebo recipients achieved a 75% improvement on the Psoriasis Area and Severity Index (PASI 75) score at 12 weeks. ▴ Other efficacy measures, including the physician's global assessment of clinical response at week 12, also favored ustekinumab over placebo. Psoriatic symptom control was maintained during ustekinumab maintenance therapy (administered once every 12 weeks) for up to 76 weeks. ▴ In a phase II trial in patients with active plaque psoriasis and psoriatic arthritis, signs and symptoms of arthritis and psoriatic symptom control were improved to a greater extent with ustekinumab than with placebo at 12 weeks, based on the proportion of patients achieving a 20% improvement in American College of Rheumatology response criteria (arthritis) or PASI 75 (skin symptoms). ▴ Health-related quality of life, assessed using the Dermatology Life Quality Index and the Health Assessment Questionnaire disability index, was improved to a significantly greater extent with ustekinumab than with placebo at week 12. ▴ Subcutaneous ustekinumab was generally well tolerated in clinical trials, with most treatment-emergent adverse events being of mild severity. Peginterferon- alpha -2a (40kD) [Pegasys(r)] is a conjugate of recombinant interferon- alpha -2a and a 40kD branched polyethylene glycol (PEG) moiety that is highly active against hepatitis C virus (HCV). Ribavirin (Copegus(r)) is a synthetic nucleoside analog that acts in synergy with the antiviral activity of peginterferon- alpha -2a (40kD). The combination of subcutaneous peginterferon- alpha -2a (40kD) once weekly plus oral ribavirin twice daily is widely approved for use in adult patients with chronic hepatitis C, including those with persistently 'normal' ALT activity or HIV-HCV co-infection, and is recommended as a first-line treatment option for patients with chronic hepatitis C and compensated liver disease. In randomized, phase III trials, the combination has consistently demonstrated good therapeutic efficacy (i.e. high sustained virologic response [SVR] rates) and has been generally well tolerated in both treatment-naive and treatment-experienced patients with chronic hepatitis C, including those with compensated, advanced liver disease. Several baseline and dynamic (on-treatment) predictors of an SVR that can be used to guide and optimize therapy were also determined in these trials and in subsequent analyses. By utilizing these predictors, therapy with peginterferon- alpha -2a (40kD) plus ribavirin can be individualized to achieve the optimal balance between efficacy and tolerability, further increasing the usefulness of this drug combination. Thus, peginterferon- alpha -2a (40kD) plus ribavirin remains a valuable therapy in patients with chronic hepatitis C, as a first-line option in those with compensated liver disease and as a second-line therapy in those with advanced liver disease. Marino Ballena National Park is located in an area thought to be chronically affected by high terrigenous sediment and nutrient loads, and high temperatures. Five coral reefs at MBNP were monitored monthly between August 2003 and April 2005. Suspended sediments, sedimentation, temperature, salinity, chlorophyll a, phosphate, silicate, nitrite, nitrate, and ammonia were measured monthly to identify which of those may have a preponderant role on the development and deterioration of the coral reefs inside the park. Live coral coverage was estimated yearly in permanent transects between 2003 and 2006. We observed a strong seasonality in the measured environmental parameters between the dry (December-April) and rainy seasons (May-November). Three principal components (PC) explained 73.6% of the variability among the environmental parameters. Reefs at MBNP are mesotrophic with respect to nutrients (PO4-3 0.241 is a subset of M, NO3 - 0.299 is a subset of M, NO2- 0.058 is a subset of M, SiO4 16.064 is a subset of M) and chlorophyll a (1.01 is a subset of g L-1) concentrations. The impact of sedimentation ranges from moderate (44 mg cm-2 d-1) to heavy (117 mg cm-2 d-1). Both nutrient and sediment loading are linked to ongoing land erosion. heavy rains carry nutrient and sediment flows into the Terraba River, and transports the nutrients and sediments into the protected area, contributing to the creation of environmental conditions in MBNP that are not typically favorable for reef development. however, the percent live coral coverage did not change significantly over the years, suggesting that corals may be increasing their tolerance to stressors. References: 41 references open in new window Articles that cite this article? The distribution of Siderastrea radians (Pallas) Blainville and photophysiology of its symbiont in Florida Bay, USA, were examined during annual macrophyte surveys in spring 2006 and 2007. Siderastrea radians was present in five of the 11 sampled basins in areas with little sediment and low abundance of the seagrass Thalassia testudinum Banks ex Konig. The five basins are located along a northeast-to-south-west transect that also represents a salinity gradient from inshore, predominantly estuarine conditions adjacent to the Everglades, to offshore near-marine salinities adjacent to the gulf of Mexico. Colony abundance was highest in the basins at the extremes of this physical range, presumably due to higher potential for larval recruitment from external reef source populations. Effective quantum yields, measured in situ by PAM fluorometry, were significantly correlated between S. radians and the dominant seagrass T. testudinum among all five basins where the two species co-occurred, albeit with a 40% reduction in mean yields of S. radians. These findings indicate S. radians may function as an alternative eco-indicator species for regions in Florida Bay where T. testudinum is absent. References: 37 references open in new window Articles that cite this article? Since 2001, biannual fish and habitat monitoring has been conducted for the shallow (> 30 m), colonized pavement and gorgonian dominated Buck Island Reef National Monument (BIRNM) St. Croix, USVI and adjacent waters. during October, 2005, widespread coral bleaching was observed within the ~50 km2 study area that was preceded by 10 wks of higher than average water temperatures (28.9-30.1 °C). Random transects (100 m2) were conducted on linear reefs, patch reefs, bedrock, pavement, and scattered coral/rock habitats during October 2005, and April and October 2006, and species specific bleaching patterns were documented. during October 2005 approximately 51% of live coral cover was bleached. Nineteen of 23 coral species within 16 genera and two hydrocoral species exhibited signs of bleaching. Coral cover for Montastraea annularis and species of the genus Agaricia were the most affected, while other species exhibited variability in their susceptibility to bleaching. Bleaching was evident at all depths (1.5-28 m), was negatively correlated with depth, and positively correlated with habitat complexity. Bleaching was less prevalent at all depths and habitat types upon subsequent monitoring during April (15%) and October (3%) 2006. Four species and one genus did not exhibit signs of bleaching throughout the study period (Dendrogyra cylindrus, Eusmilia fastigata, Mussa angulosa, Mycetophyllia aliciae, Scolymia spp.). References: 25 references open in new window Articles that cite this article? The Echeneoidea comprise three families of cosmopolitan tropical/subtropical marine fishes: the Echeneidae (remoras), Coryphaenidae (dolphinfishes), and Rachycentridae (cobia). Complete nucleotide sequences from the mitochondrial 12S rRNA, 16S rRNA, protein-coding ND2, and nuclear ITS-1 gene regions were used to reconstruct the phylogenetic history of these fishes. Parsimony, maximum likelihood, and Bayesian analyses of combined data sets resolved trees of similar topology. Congruent with evolutionary hypotheses based on larval morphology, a monophyletic Rachycentridae + Coryphaenidae was resolved with high support. Within a monophyletic Echeneidae, the subfamilies Echeneinae and Remorinae were monophyletic. In agreement with recent morphological analyses, the genus Remora was paraphyletic based on the position of Remorina albescens Temminck and Schlegel, 1850. Consistent resolution within the Remorinae using parsimony, maximum likelihood, and Bayesian inference was not achieved with the gene regions surveyed in this study. References: 20 references open in new window Articles that cite this article? Abstract not available. During 2006 and 2007, the first comprehensive, quantitative coral disease assessment was conducted at seven coral islands and atolls in the central Pacific: Johnston, Palmyra, Kingman, and Wake Atolls, and Howland, Baker, and Jarvis Islands. Collectively, they are referred to as Pacific Remote Island Areas (PRIA), spanning over 4000 km and nearly 20° latitude. Distribution and prevalence of disease were determined from 25-m belt transects at 80 sites, covering an area of over 22,000 m2 of reef habitat. Six broad disease categories were recognized affecting 12 different scleractinian genera; prevalence was computed based on the estimated total number of coral colonies per survey site. The most geographically and taxonomically widespread disease was skeletal growth anomalies detected at nearly 40% of sites and on six different anthozoan genera. In contrast, the most prevalent disease was acute tissue loss (or white syndrome) which was hosted by four scleractinian genera, including Acropora, Montipora, Goniastrea, and Platygyra. Pigmentation response and other sublethal lesions, such as algal and cyanophyte infections, and tube-worm infestations, were infrequent and occurred in low prevalences. The overall abundance of coral diseases in the U.S. PRIA was low; however, patterns of prevalence varied among coral genera and indicated a few taxa were disproportionately affected by disease, namely the Acroporidae and Poritidae. Of potential concern is white syndrome, which results in severe and rapid tissue loss, particularly on the tabular Acropora cytherea (Dana, 1846) at Johnston Atoll. References: 12 references open in new window Articles that cite this article? During several surveys conducted in shallow, temperate waters of northern Patagonia, we found hydroids belonging to the family Corymorphidae. Additionally, sorting more than 2700 plankton samples yielded five specimens of a corymorphid medusa. Both stages belong to Corymorpha januarii Steenstrup, 1854, a hydrozoan rarely reported in the literature. This finding extends southwards its geographic distribution and represents the first Subantarctic record, as well as the first finding of the medusa stage in nature, confirming its endemism in the tropical and temperate waters of the Southwestern Atlantic. References: 12 references open in new window Articles that cite this article? Recent studies have highlighted the biomass and ecological roles of benthic microalgae (BMA) on the continental shelf. However, few studies have specifically examined BMA in the north-central Gulf of Mexico. We examined the origin and biomass of sediment associated algae on Ship Shoal, a submerged sandbank with depth and sediment characteristics favorable to benthic primary production. Light levels at the sediment surface ranged from < 1% to 30% of surface PAR, and were judged sufficient for benthic photosynthesis throughout the year. Sediment algal biomass, as chlorophyll a, was highest in the spring and summer and was not consistently correlated with any of the physical parameters recorded including sediment light levels and water depth. Photosynthetic pigment analysis indicated sedimentary algae across Ship Shoal were predominately diatoms on all sampling dates. Microscopic analysis suggested the diatoms were primarily BMA with only a minor fraction of settled phytoplankton. Our results differ from studies of muddy sediments which have typically found that sediment algae on the Louisiana shelf were derived from phytoplankton. Comparison of pigments from the sediment and bottom water suggested weak exchange of benthic and pelagic algae between the two compartments. Algal biomass in the sediment exceeded that of the overlying water column over much of Ship Shoal during the spring and summer. The high benthic algal biomass (equivalent to typical estuarine values) suggests benthic primary product (BPP) may contribute to the Ship Shoal food web and that BPP may be an important ecosystem component on the other large shoals found on Louisiana's inner shelf. References: 47 references open in new window Articles that cite this article? Abstract not available. Abstract not available. Background. This study was set up to explore unexpected findings emergent from a randomized controlled trial of exercise versus relaxation post-stroke. Purpose. Stroke survivors' experiences of taking part in exercise and relaxation classes were explored. Methods. In-depth, semi-structured interviews carried out with 14 community-dwelling stroke survivors in Edinburgh. The informants previously participated in a randomized exploratory trial of exercise versus relaxation. Findings. The classes motivated participants to take part in other purposeful activities, to continue to practice what they had learned, and/or to attend another class in the community. Class participation also led to an improvement of self-perceived quality of life, specifically, improved confidence, physical ability, psychosocial functioning, and a sense of empowerment. Implications. Taking part in either exercise or relaxation classes after stroke can contribute to improved self-perceived quality of life, improved psychosocial functioning, and improved motivation to take an active role in the recovery process. FrenchDescription. Cette etude a ete menee en vue d'examiner les resultats imprevus d'un essai controle aleatoire comportant des seances d'exercice et des seances de relaxation chez des patients ayant subi un accident vasculaire cerebral (AVC). But. Les experiences vecues par des survivants d'un AVC ayant participe a des seances d'exercice ou a des seances de relaxation ont ete etudiees. Methodologie. Des entrevues en profondeur semi-structurees ont ete menees aupres de 14 survivants d'un AVC vivant dans la collectivite a Edinburgh. Les informateurs avaient participe auparavant a un essai exploratoire aleatoire comportant des seances d'exercice et des seances de relaxation. Resultats. Les seances motivaient les participants a participer a d'autres activites significatives, a continuer de mettre en pratique ce qu'ils avaient appris ou a assister a d'autres cours dans la communaute. La participation a ces seances a egalement permis aux participants d'ameliorer leur perception face a leur qualite de vie, en particulier d'ameliorer leur confiance, leurs habiletes physiques et leur fonctionnement psychosocial et d'avoir un sentiment de pouvoir sur leur vie. Consequences. La participation a des seances d'exercice ou de relaxation a la suite d'un AVC peut contribuer a l'amelioration de la perception de la qualite de vie, du fonctionnement psychosocial et de la motivation a participer activement au processus de retablissement. Articles that cite this article? Background. Consumer feedback about experiences with the health system is integral to service planning and is consistent with growing interest in patient-centred care. Purpose. To explore the experiences of community-dwelling stroke survivors at one, three, and five years using a community-based, cross-sectional study. Methods. The quantitative study was comprised of 90 participants post-stroke (3 cohorts, each including 30 participants). Qualitative interviews were undertaken with 12 participants (4 participants from each cohort). This paper presents findings from the qualitative component of the project. Findings. The majority of participants in each cohort were independent and a high proportion required community services. Qualitative data identified varied experiences with the health system, including knowledge about stroke, communication with the health system, and influences on transition home. Implications. The results presented identify the need for ongoing health professional education to enhance stroke service delivery. There is a particular need to address stroke risk-factor modification and to ensure close collaboration with patients and other health professionals with regard to rehabilitation processes. Results identify experiences with health systems up to five years post-stroke. Occupational therapy can play an essential role in post-stroke education and in rehabilitation focused on adjustment to stroke. FrenchDescription. Les commentaires des consommateurs sur les experiences qu'ils ont vecues face au systeme de sante font partie integrante de la planification des services et temoignent de l'interet croissant pour les soins centres sur le patient. But. Examiner les experiences vecues par des survivants d'un accident vasculaire cerebral (AVC) vivant dans la collectivite un an, trois ans et cinq ans apres leur AVC, a partir d'une etude transversale a base communautaire. Methodologie. L'etude quantitative regroupait 90 participants ayant subi un accident vasculaire cerebral (3 cohortes comprenant chacune 30 participants). Des entrevues qualitatives ont ete menees aupres de 12 participants (4 participants de chaque cohorte). Cet article presente les resultats de la composante qualitative du projet. Resultats. La majorite des participants de chaque cohorte etaient autonomes et une forte proportion avaient besoin de services communautaires. Les donnees qualitatives ont permis de determiner que les participants avaient vecues des experiences variables face au systeme de sante, notamment face a la transmission de connaissances sur les AVC, a la communication au sein du systeme de sante et aux facteurs influant sur la transition vers le domicile. Consequences. Les resultats presentes permettent de cibler le besoin de formation continue chez les professionnels de la sante en vue de rehausser la prestation des services offerts aux personnes ayant subi un AVC. Les resultats indiquent aussi le besoin particulier d'aborder la modification du facteur de risque de l'AVC et de s'assurer d'une etroite collaboration avec les patients et les autres professionnels de la sante, en ce qui concerne les processus de readaptation. Les resultats indiquent que les participants ont eu des experiences avec les systemes de sante jusqu'a cinq ans apres leur AVC. L'ergotherapie peut jouer un role essentiel dans l'education relative aux AVC et dans la readaptation centree sur l'adaptation a la suite d'un AVC. Articles that cite this article? Background. Anecdotal and empirical evidence indicates children with intractable epilepsy have difficulty completing daily occupations. There is a paucity of literature describing these issues from a client-centred perspective. Occupational issues in childhood epilepsy have historically been assessed by disability inventories. Purpose. This pilot study seeks to determine similarities and differences between occupational issues identified using a disability inventory and an individualized outcome measure among children with intractable epilepsy and their parents. Method. Goal identification was determined using two approaches to standardized measurement with 10 child-caregiver dyads. The Canadian Occupational Performance Measure (COPM) was the individualized measure for both parents and children. The Scales of Independent Behavior-Revised (SIB-R) disability inventory was completed by parents only. Agreement between the top three issues identified by the child COPM, parent COPM, and subscales of the SIB-R were compared. Findings. Although both of the outcomes employed in this study are standardized measures, they resulted in low agreement and the identification of different occupational issues for children with intractable epilepsy. Implications. This study provides a comparison of two different approaches to identifying goals. It also provides preliminary information on the types of occupational performance issues prioritized by children with intractable epilepsy and their parents. FrenchDescription. Des donnees anecdotiques et empiriques indiquent que les enfants ayant une epilepsie refractaire ont de la difficulte a realiser leurs occupations quotidiennes. On retrouve peu d'articles dans la litterature decrivant ces difficultes selon une perspective centree sur le client. Dans le passe, les difficultes occupationnelles associees a l'epilepsie infantile etaient evaluees a l'aide d'inventaires des handicaps. But. Cette etude pilote cherche a determiner les similitudes et les differences entre les difficultes occupationnelles identifiees par des enfants atteints d'epilepsie refractaire et par leurs parents, a l'aide d'un inventaire des handicaps et d'une mesure des resultats individualisee. Methodologie. Les objectifs ont ete determines a l'aide de deux mesures strandardisees aupres de 10 dyades enfant-aidant. La Mesure canadienne du rendement occupationnel (MCRO) a ete utilisee pour les parents et pour les enfants. Les echelles de l'inventaire des handicaps Scales of Independent Behavior-Revised (SIB-R) ont ete remplies uniquement par les parents. Les similitudes entre les trois principaux problemes identifies a l'aide de la MCRO de l'enfant, de la MCRO du parent et des echelles secondaires du SIB-R ont ete comparees. Resultats. Bien que les deux mesures des resultats employees dans cette etude soient des mesures standardisees, elles ont donne lieu a moins de similitudes, de meme qu'a la determination de difficultes occupationnelles differentes chez les enfants ayant une epilepsie refractaire. Consequences. Cette etude permet de comparer deux approches differentes concues pour determiner des objectifs. Elle fournit egalement de l'information preliminaire sur les types de difficultes en matiere de rendement occupationnel auxquels les enfants atteints d'epilepsie refractaire et leurs parents accordent la priorite. Articles that cite this article? Background. Intensive efforts are aimed at understanding student attributes in anticipation that this will lead to effective knowledge translation (KT) strategies. One attribute of interest is practice style trait: four have been identified ranging from the seeker, who is driven by scientific evidence, to the pragmatist, who is driven by practicality. Purpose. To identify the prevalence of the four traits among student clinicians and explore associations between these traits, clinician characteristics and practice behaviours. Methods. Ninety-two occupational therapy and 86 physical therapy students completed a survey that elicited information on traits, clinician characteristics, and practice behaviours. Findings. The most prevalent trait was pragmatic, the least, seeker at <1%. The most prevalent reason for choosing an intervention was 'it was used by my clinical supervisor'. Implications. Educators should carefully reconsider the implication of using KT strategies that cater primarily to seekers. Research is warranted to explore the impact of matching educational strategies to traits. FrenchDescription. D'intenses efforts sont deployes dans le but de mieux comprendre les attributs des etudiants, en supposant que cela peut entrainer des strategies plus efficaces de transfert des connaissances. L'un des attributs presentant un interet est le trait de caractere associe au style de pratique; quatre traits de caractere ont ete determines, allant du chercheur, qui s'interesse aux faits scientifiques, au pragmatique, qui est interesse par l'aspect pratique des choses. But. Determiner la prevalence des quatre traits de caractere chez les etudiants cliniciens et examiner les associations entre ces traits, les caracteristiques des cliniciens et les attitudes des cliniciens dans la pratique. Methodologie. Quatre-vingt-douze etudiants en ergotherapie et 86 etudiants en physiotherapie ont repondu a un questionnaire qui recueillait de l'information sur les traits de caractere, les caracteristiques et les attitudes du clinicien. Resultats. Le trait de caractere le plus prevalent etait celui du pragmatique et le moins prevalent etait celui du chercheur, a < 1 %. La raison la plus frequente donnee par les etudiants pour justifier le choix d'une intervention etait la suivante : " elle etait utilisee par mon superviseur clinique ". Consequences. Les educateurs doivent reexaminer soigneusement les consequences associees a l'utilisation de strategies de transfert des connaissances qui s'adressent principalement aux chercheurs. Des recherches devront etre menees afin d'examiner les effets de la mise en correspondance des strategies d'enseignement avec les traits de caractere. Articles that cite this article? Background. Critics contend that occupational therapy's theories of occupation are culturally specific, class-bound, and ableist, and that the division of all occupations into three simplistic categories of self-care, productivity, and leisure is arbitrary, lacks supportive evidence, and promotes a doctrine of individualism. Purpose. To add to the work of critics who advocate a fundamental rethinking of occupational therapy's conceptualizations of occupation in terms of subjective qualities of experience that address intrinsic needs. Key issues. This paper suggests that if categories of occupation were informed by the ways in which people experience their occupations, these might be labelled as restorative, as ways to connect and contribute, as engagement in doing, and as ways to connect the past and present to a hopeful future. Implications. If occupational therapists enabled diverse clients' perspectives to inform occupational categories, perhaps relationships between occupations and well-being might more easily be identified in theory and addressed in practice. FrenchDescription. Certains critiques affirment que les theories sur l'occupation sont teintees de capacitisme et qu'elles sont associees a certaines cultures et classes; ils considerent que la division de toutes les occupations en trois categories simplistes, soient les soins personnels, la productivite et les loisirs, est arbitraire, qu'elle n'est pas justifiee par suffisamment de donnees probantes et qu'elle favorise une doctrine de l'individualisme. But. Ajouter aux travaux des critiques qui preconisent le besoin de revoir fondamentalement les concepts de l'occupation en ergotherapie en fonction des qualites subjectives des experiences qui repondent a des besoins intrinseques. Questions cles. Cet article suggere que si les categories d'occupations etaient definies par les experiences vecues par les gens a travers leurs occupations, il serait alors possible de les designer comme des facons de se retablir, des facons d'etablir des liens et de participer, des facons de participer en accomplissant des choses et des facons de relier le passe et le present a un avenir fonde sur l'espoir. Consequences. Si les ergotherapeutes prenaient en compte les diverses perspectives des clients pour definir les categories d'occupations, il serait peut-etre plus facile de definir theoriquement les relations entre les occupations et le bien-etre et de les aborder dans la pratique. Articles that cite this article? Background. Meta-cognitive strategies have a positive effect on the rehabilitation of executive dysfunction. However, achieving generalization to daily life remains a challenge. We believe that providing rehabilitation in the person's own physical environment and using self-identified tasks will enhance the benefits of meta-cognitive training and promote generalization. Purpose. This pilot study tested the applicability of the Cognitive Orientation to Occupational Performance (CO-OP) approach for use with adults with executive dysfunction arising from traumatic brain injury (TBI). Methods. A single-case design was used with 3 adults, 5 to 20 years post-TBI and their self-identified significant others. Assessments included neuropsychological tests and the Canadian Occupational Performance Measure. The intervention entailed guiding participants to use a meta-cognitive problem-solving strategy to perform self-identified daily tasks that they needed and wanted to do and with which they were having difficulties. The intervention occurred over 20 one-hour sessions in participants' environments. Findings. Performance improved to criterion (2-point positive change) on 7 of 9 trained goals and on 4 of 7 untrained goals (self-report). Improvement was maintained at a 3-month follow-up assessment. Implications. The CO-OP approach has the potential to improve performance in daily functioning for adults with executive dysfunction following TBI. FrenchDescription. Les strategies metacognitives ont un effet positif sur la readaptation des personnes ayant des troubles des fonctions executives. Toutefois, la generalisation des acquis dans la vie quotidienne demeure difficile. Nous croyons que certains facteurs peuvent rehausser les avantages de la readaptation metacognitive et favoriser la generalisation des acquis, comme la readaptation se produisant dans l'environnement physique de la personne, c'est-a-dire a son domicile, le fait que la personne fait ses courses ou non et l'utilisation de taches significatives, identifiees par la personne. But. Cette etude pilote avait pour but d'evaluer si l'approche Cognitive Orientation to Occupational Performance (CO-OP) serait efficace aupres d'adultes ayant des troubles des fonctions executives a la suite d'un traumatisme craniocerebral. Methodologie. Une etude de cas a echantillonnage simple a ete utilisee aupres de trois adultes ayant subi un traumatisme craniocerebral dans les 5 a 20 dernieres annees et des personnes signifiantes identifiees par les participants (c'est-a-dire, une personne qui connait bien le sujet et qui le voit regulierement). Les evaluations utilisees etaient des tests neuropsychologiques et la Mesure canadienne du rendement occupationnel. L'intervention consistait a guider les participants afin qu'ils puissent utiliser une strategie metacognitive pour resoudre des problemes; cette strategie consistait a choisir et a realiser des taches qu'ils voulaient et devaient faire, mais devant lesquelles ils eprouvaient de la difficulte. L'intervention s'est deroulee pendant 20 seances d'une heure dans l'environnement des participants. Resultats. Le rendement s'est ameliore selon certains criteres (changement positif de 2 points) sur 7 des 9 buts pour lesquels les participants ont recu une intervention et sur 4 des 7 buts sans intervention (tel que rapporte par les participants). L'amelioration s'est maintenue jusqu'a l'evaluation de suivi trois mois plus tard. Consequences. L'approche CO-OP pourrait ameliorer le rendement au quotidien des adultes ayant des troubles des fonctions executives a la suite d'un traumatisme craniocerebral. Articles that cite this article? Abstract not available. JF - Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry AU - Moretti, A AU - Augurio, A AU - Croce, A AD - Clinical Immunotherapy Section, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 101 EP - 113 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 8 IS - 1 SN - 1871-5230, 1871-5230 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Sustainability Science Abstracts; Biotechnology and Bioengineering Abstracts KW - Mene KW - Reefs KW - ASW, USA, Louisiana KW - Acroporidae KW - Ribavirin KW - Bacillariophyceae KW - Basins KW - Eusmilia KW - Nutrients KW - Clinical trials KW - stroke KW - Mycetophyllia aliciae KW - coral bleaching KW - Psoriasis KW - PSW, Argentina, Patagonia KW - I, Pacific KW - Mussa angulosa KW - Agaricia KW - Corals KW - Hepatitis C KW - Glioma KW - Algae KW - I, Central Pacific KW - USA, California, Point Sur KW - Inventories KW - Liver diseases KW - Bleaching KW - Coryphaenidae KW - miRNA KW - Dendrogyra KW - Acropora cytherea KW - CD34 antigen KW - Biomass KW - Habitat KW - British Isles, Scotland, Edinburgh KW - Toxins KW - Physical training KW - Hepatitis KW - ASW, Lesser Antilles, US Virgin Is., Buck I. KW - Hepatitis C virus KW - ISE, Pacific, Johnston Atoll KW - rhinosinusitis KW - Coral reefs KW - Thalassia testudinum KW - disabilities KW - psoriasis KW - Poritidae KW - Pseudomonas KW - Corymorphidae KW - Leukemia KW - ASW, USA, Florida, Everglades KW - Remora KW - Islands KW - Acropora KW - intervention KW - Syria, Palmyra KW - growth factors KW - Drugs KW - Sediment pollution KW - Rehabilitation KW - Platygyra KW - Stroke KW - Siderastrea radians KW - ASW, USA, Louisiana, Ship Shoal KW - Montipora KW - Toxicity KW - Children KW - Scolymia KW - Cancer KW - Pharmacokinetics KW - Sediments KW - Immunotoxins KW - Goniastrea KW - Inflammation KW - ASW, Mexico Gulf KW - Scleractinia KW - Brain tumors KW - USA KW - Corymorpha KW - Human immunodeficiency virus KW - Epilepsy KW - Rachycentridae KW - Reviews KW - Proteins KW - Echeneidae KW - Montastraea annularis KW - Remorina albescens KW - ASW, USA, Florida, Florida Bay KW - Gorgonacea KW - W 30925:Genetic Engineering KW - A 01450:Environmental Pollution & Waste Treatment KW - M3 1010:Issues in Sustainable Development KW - J 02400:Human Diseases KW - V 22370:Oncology KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20543572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-Inflammatory+and+Anti-Allergy+Agents+in+Medicinal+Chemistry&rft.atitle=Anti-Inflammatory+and+Anti-Allergy+Drugs+in+Rhinosinusitis&rft.au=Moretti%2C+A%3BAugurio%2C+A%3BCroce%2C+A&rft.aulast=Moretti&rft.aufirst=A&rft.date=2009-03-01&rft.volume=8&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Anti-Inflammatory+and+Anti-Allergy+Agents+in+Medicinal+Chemistry&rft.issn=18715230&rft_id=info:doi/10.2174%2F187152309787580748 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Reefs; Ribavirin; Nutrients; Clinical trials; Islands; Psoriasis; Corals; Glioma; Hepatitis C; Algae; Inventories; Liver diseases; Rehabilitation; Bleaching; Stroke; miRNA; CD34 antigen; Children; Habitat; Biomass; Immunotoxins; Sediments; Pharmacokinetics; Toxins; Physical training; Inflammation; Brain tumors; Epilepsy; Reviews; Coral reefs; rhinosinusitis; Sediment pollution; disabilities; psoriasis; Basins; Toxicity; Cancer; Hepatitis; Leukemia; stroke; coral bleaching; intervention; Proteins; Drugs; growth factors; Mene; Acroporidae; Bacillariophyceae; Poritidae; Eusmilia; Pseudomonas; Corymorphidae; Mycetophyllia aliciae; Remora; Acropora; Mussa angulosa; Agaricia; Platygyra; Coryphaenidae; Siderastrea radians; Dendrogyra; Acropora cytherea; Montipora; Scolymia; Goniastrea; Scleractinia; Corymorpha; Hepatitis C virus; Human immunodeficiency virus; Rachycentridae; Thalassia testudinum; Echeneidae; Montastraea annularis; Remorina albescens; Gorgonacea; USA, California, Point Sur; I, Central Pacific; ASW, USA, Louisiana; ASW, USA, Louisiana, Ship Shoal; British Isles, Scotland, Edinburgh; ASW, Mexico Gulf; USA; ASW, USA, Florida, Everglades; ASW, Lesser Antilles, US Virgin Is., Buck I.; ISE, Pacific, Johnston Atoll; I, Pacific; PSW, Argentina, Patagonia; Syria, Palmyra; ASW, USA, Florida, Florida Bay DO - http://dx.doi.org/10.2174/187152309787580748 ER - TY - JOUR T1 - Recombinant Immunotoxins Containing Truncated Bacterial Toxins for the Treatment of Hematologic Malignancies AN - 20539229; 9224217 AB - Immunotoxins are molecules that contain a protein toxin and a ligand that is either an antibody or a growth factor. The ligand binds to a target cell antigen, and the target cell internalizes the immunotoxin, allowing the toxin to migrate to the cytoplasm where it can kill the cell. In the case of recombinant immunotoxins, the ligand and toxin are encoded in DNA that is then expressed in bacteria, and the purified immunotoxin contains the ligand and toxin fused together. Among the most active recombinant immunotoxins clinically tested are those that are targeted to hematologic malignancies. One agent, containing human interleukin-2 and truncated diphtheria toxin (denileukin diftitox), has been approved for use in cutaneous T-cell lymphoma, and has shown activity in other hematologic malignancies, including leukemias and lymphomas. Diphtheria toxin has also been targeted by other ligands, including granulocyte-macrophage colony-stimulating factor and interleukin-3, to target myelogenous leukemia cells. Single-chain antibodies containing variable heavy and light antibody domains have been fused to truncated Pseudomonas exotoxin to target lymphomas and lymphocytic leukemias. Recombinant immunotoxins anti-Tac(Fv)-PE38 (LMB-2), targeting CD25, and RFB4(dsFv)-PE38 (BL22, CAT-3888), targeting CD22, have each been tested in patients. Major responses have been observed after failure of standard chemotherapy. The most successful application of recombinant immunotoxins today is in hairy cell leukemia, where BL22 has induced complete remissions in most patients who were previously treated with optimal chemotherapy. JF - Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry AU - Kreitman, Robert J AD - Clinical Immunotherapy Section, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 1 EP - 13 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 8 IS - 1 SN - 1871-5230, 1871-5230 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 2 KW - Myeloid leukemia KW - Interleukin 3 KW - Chemotherapy KW - Lymphatic leukemia KW - Pseudomonas KW - CD22 antigen KW - Malignancy KW - Cytoplasm KW - Cell migration KW - Growth factors KW - Bacteria KW - Granulocyte-macrophage colony-stimulating factor KW - Remission KW - CD25 antigen KW - Exotoxins KW - Diphtheria toxin KW - Toxins KW - Immunotoxins KW - Inflammation KW - Antibodies KW - double prime T-cell lymphoma KW - DNA KW - Hairy cell leukemia KW - X 24370:Natural Toxins KW - F 06955:Immunomodulation & Immunopharmacology KW - A 01490:Miscellaneous KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20539229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-Inflammatory+and+Anti-Allergy+Agents+in+Medicinal+Chemistry&rft.atitle=Recombinant+Immunotoxins+Containing+Truncated+Bacterial+Toxins+for+the+Treatment+of+Hematologic+Malignancies&rft.au=Kreitman%2C+Robert+J&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-03-01&rft.volume=8&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Anti-Inflammatory+and+Anti-Allergy+Agents+in+Medicinal+Chemistry&rft.issn=18715230&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Interleukin 2; Interleukin 3; Myeloid leukemia; Chemotherapy; Lymphatic leukemia; Granulocyte-macrophage colony-stimulating factor; Remission; CD25 antigen; Immunotoxins; Toxins; Diphtheria toxin; Exotoxins; Inflammation; Antibodies; Malignancy; CD22 antigen; double prime T-cell lymphoma; Cytoplasm; DNA; Growth factors; Cell migration; Hairy cell leukemia; Bacteria; Pseudomonas ER - TY - JOUR T1 - Recognition of NY-ESO-1+ tumor cells by engineered lymphocytes is enhanced by improved vector design and epigenetic modulation of tumor antigen expression AN - 20531073; 9198670 AB - The therapeutic use of T cell receptor (TCR)-transduced peripheral blood lymphocytes (PBL) targeting tumor-associated antigens is emerging as a promising investigational treatment for patients with cancer. Initial response rates to therapy were low, suggesting the need to improve the function of TCR-transduced PBL. We constructed standard bicistronic retroviral vectors using an internal promoter or internal ribosomal entry site element as well as vectors incorporating coding sequences for 2A linker peptides between coding sequences for alpha and beta chains targeting the cancer-testis (CT) antigen, NY-ESO-1. Incorporation of coding sequences for 2A linker peptides in the bicistronic TCR expression cassette resulted in up to a fourfold increase in TCR expression and a significant improvement in effector function as measured by interferon-gamma release following co-culture with peptide-pulsed targets and NY-ESO-1+ tumors. We also sought to enhance reactivity of TCR-transduced PBL against tumor targets by modulation of tumor antigen expression on target cells. Induction of NY-ESO-1 expression on tumor targets using the demethylating agent 5-aza-2 double prime -deoxycytidine (alone or in combination with the histone deacetylase inhibitor depsipeptide) resulted in enhanced interferon-gamma secretion by the TCR-transduced PBL on culture with treated targets. Taken together, these results indicate that design of TCR-based vectors incorporating 2A linker peptides improves TCR expression and effector function of transduced PBL. Furthermore, induction of CT antigen expression through treatment of tumor targets with chromatin-remodeling agents may augment TCR-based immunotherapy targeting these antigens. These results have relevance for TCR-based gene therapies targeting common epithelial malignancies. JF - Cancer Immunology, Immunotherapy AU - Wargo, Jennifer A AU - Robbins, Paul F AU - Li, Yong AU - Zhao, Yangbing AU - El-Gamil, Mona AU - Caragacianu, Diana AU - Zheng, Zhili AU - Hong, Julie A AU - Downey, Stephanie AU - Schrump, David S AU - Rosenberg, Steven A AU - Morgan, Richard A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10/Rm 3-5940, Bethesda, MD, 20892, USA, rmorgan@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 383 EP - 394 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 58 IS - 3 SN - 0340-7004, 0340-7004 KW - Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - gamma -Interferon KW - Histone deacetylase KW - Chromatin remodeling KW - Gene therapy KW - Immunotherapy KW - double prime T-cell receptor KW - Cell culture KW - Peripheral blood KW - Tumors KW - Tumor cells KW - Cancer KW - Expression vectors KW - Promoters KW - Malignancy KW - epigenetics KW - NY-ESO-1 protein KW - Antigen (tumor-associated) KW - W 30905:Medical Applications KW - N 14820:DNA Metabolism & Structure KW - F 06915:Cancer Immunology KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20531073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Immunology%2C+Immunotherapy&rft.atitle=Recognition+of+NY-ESO-1%2B+tumor+cells+by+engineered+lymphocytes+is+enhanced+by+improved+vector+design+and+epigenetic+modulation+of+tumor+antigen+expression&rft.au=Wargo%2C+Jennifer+A%3BRobbins%2C+Paul+F%3BLi%2C+Yong%3BZhao%2C+Yangbing%3BEl-Gamil%2C+Mona%3BCaragacianu%2C+Diana%3BZheng%2C+Zhili%3BHong%2C+Julie+A%3BDowney%2C+Stephanie%3BSchrump%2C+David+S%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Wargo&rft.aufirst=Jennifer&rft.date=2009-03-01&rft.volume=58&rft.issue=3&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Cancer+Immunology%2C+Immunotherapy&rft.issn=03407004&rft_id=info:doi/10.1007%2Fs00262-008-0562-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; gamma -Interferon; Gene therapy; Chromatin remodeling; double prime T-cell receptor; Immunotherapy; Peripheral blood; Cell culture; Tumors; Tumor cells; Cancer; Expression vectors; Promoters; Malignancy; NY-ESO-1 protein; epigenetics; Antigen (tumor-associated) DO - http://dx.doi.org/10.1007/s00262-008-0562-x ER - TY - JOUR T1 - ABC Transporters, Drug Resistance, and Cancer Stem Cells AN - 20514415; 9204525 AB - The protection of the body's stem cells from damage or death due to toxins is a critical function of an organism, as the stem cells need to remain intact for the entire life of the organism. One of the principal mechanisms for protecting stem cells is through the expression of multifunctional efflux transporters from the ATP-binding cassette (ABC) gene family. These same transporters have been known for over 25 years to also play a role in multidrug resistance of tumor cells. An exciting outcome of the concept of the cancer stem cell is that the tumor initiating cell may be innately resistant to many standard therapies. This provides one mechanism in which cancer stem cells could survive cytotoxic or targeted therapies and lead to tumor regrowth or relapse. Gaining a better insight into the mechanisms of stem cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anti-cancer strategies. JF - Journal of Mammary Gland Biology and Neoplasia AU - Dean, Michael AD - Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD, 21702, USA, dean@ncifcrf.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 3 EP - 9 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 VL - 14 IS - 1 SN - 1083-3021, 1083-3021 KW - Biotechnology and Bioengineering Abstracts KW - ABC transporter KW - Mammary gland KW - Chemotherapy KW - Drug resistance KW - Tumors KW - Gene families KW - Tumor cells KW - Cancer KW - Toxins KW - Stem cells KW - Cytotoxicity KW - Multidrug resistance KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20514415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Mammary+Gland+Biology+and+Neoplasia&rft.atitle=ABC+Transporters%2C+Drug+Resistance%2C+and+Cancer+Stem+Cells&rft.au=Dean%2C+Michael&rft.aulast=Dean&rft.aufirst=Michael&rft.date=2009-03-01&rft.volume=14&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Mammary+Gland+Biology+and+Neoplasia&rft.issn=10833021&rft_id=info:doi/10.1007%2Fs10911-009-9109-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Stem cells; Mammary gland; ABC transporter; Drug resistance; Chemotherapy; Multidrug resistance; Tumors; Gene families; Tumor cells; Toxins; Cancer DO - http://dx.doi.org/10.1007/s10911-009-9109-9 ER - TY - JOUR T1 - Vulnerability in Research: Individuals with Limited Financial and/or Social Resources AN - 20513928; 9194914 AB - Individuals with limited resources are often presumed to be vulnerable in research. Concerns include the possibility of impaired decision making, susceptibility to undue inducement, and risk of exploitation. Although each of these concerns should be considered by investigators and IRBs, none justifies categorical exclusion of individuals with limited resources. JF - Journal of Law, Medicine & Ethics AU - Grady, Christine AD - 1Head of the Section on Human Subjects Research in the Department of Bioethics at the Clinical Center, National Institutes of Health. Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 19 EP - 27 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 37 IS - 1 SN - 1073-1105, 1073-1105 KW - Risk Abstracts KW - Ethics KW - vulnerability KW - R2 23070:Economics, organization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20513928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Law%2C+Medicine+%26+Ethics&rft.atitle=Vulnerability+in+Research%3A+Individuals+with+Limited+Financial+and%2For+Social+Resources&rft.au=Grady%2C+Christine&rft.aulast=Grady&rft.aufirst=Christine&rft.date=2009-03-01&rft.volume=37&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+Law%2C+Medicine+%26+Ethics&rft.issn=10731105&rft_id=info:doi/10.1111%2Fj.1748-720X.2009.00347.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Ethics; vulnerability DO - http://dx.doi.org/10.1111/j.1748-720X.2009.00347.x ER - TY - JOUR T1 - Novel CD19 expression in a peripheral T cell lymphoma: A flow cytometry case report with morphologic correlation AN - 20505661; 9170069 AB - Background Peripheral T-cell lymphomas are uncommon lymphomas that show T-cell antigenic loss and clonal T-cell receptor (TCR) gene rearrangement. Rare cases of T-cell lymphomas with aberrant expression of CD20 have been described. However, CD19 coexpression in a mature T-cell neoplasm has not been reported. Methods Histology, immunohistochemistry (IHC), and PCR for TCR gene rearrangement were performed on an excised lymph node specimen and a subsequent fine needle aspiration (FNA) of an additional lymph node. Flow cytometry (FC) was performed on FNA and peripheral blood specimen. Results The lymph node's architecture was effaced by a diffuse atypical lymphoid proliferation that, by IHC, was positive for CD3, CD2, and CD43 and negative for CD4, CD5, CD8, TdT, CD1a, and B-cell-associated antigens PAX-5, CD20, and CD79a. A clonal TCR gene rearrangement was detected. FC was performed on a subsequent FNA, and peripheral blood specimen demonstrated an aberrant T-cell population with expression of CD2, CD3, CD27, TCR /, CD52, CD38, CD45, and CD26 (partial expression) and negative for CD4, CD5, CD7, CD8, CD10, CD30, and CD56. The aberrant T-cell population also expressed bright CD19. Conclusions Using FC, we describe the first case of peripheral T-cell lymphoma with aberrant coexpression of CD19. Published 2008 Wiley-Liss, Inc. JF - Cytometry Part B AU - Rizzo, Kathryn AU - Stetler-Stevenson, Maryalice AU - Wilson, Wyndham AU - Yuan, Constance M AD - Flow Cytometry Unit, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, yuanc@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 142 EP - 149 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 76B IS - 2 SN - 1552-4949, 1552-4949 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - CD38 antigen KW - CD26 antigen KW - Flow cytometry KW - CD7 antigen KW - CD43 antigen KW - CD4 antigen KW - Pax5 protein KW - CD27 antigen KW - CD5 antigen KW - CD20 antigen KW - Lymphocytes T KW - Polymerase chain reaction KW - CD19 antigen KW - CD45 antigen KW - CD56 antigen KW - double prime T-cell receptor KW - CD30 antigen KW - Lymph KW - Peripheral blood KW - CD8 antigen KW - Lymph nodes KW - Case reports KW - double prime T-cell lymphoma KW - gene rearrangement KW - CD2 antigen KW - CD3 antigen KW - Immunohistochemistry KW - DNA nucleotidylexotransferase KW - F 06915:Cancer Immunology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20505661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+B&rft.atitle=Novel+CD19+expression+in+a+peripheral+T+cell+lymphoma%3A+A+flow+cytometry+case+report+with+morphologic+correlation&rft.au=Rizzo%2C+Kathryn%3BStetler-Stevenson%2C+Maryalice%3BWilson%2C+Wyndham%3BYuan%2C+Constance+M&rft.aulast=Rizzo&rft.aufirst=Kathryn&rft.date=2009-03-01&rft.volume=76B&rft.issue=2&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+B&rft.issn=15524949&rft_id=info:doi/10.1002%2Fcyto.b.20442 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - CD38 antigen; CD26 antigen; Flow cytometry; CD4 antigen; CD43 antigen; CD7 antigen; Pax5 protein; CD27 antigen; CD20 antigen; CD5 antigen; Lymphocytes T; Polymerase chain reaction; CD19 antigen; CD45 antigen; CD56 antigen; double prime T-cell receptor; CD30 antigen; Peripheral blood; Lymph; CD8 antigen; Lymph nodes; Case reports; gene rearrangement; double prime T-cell lymphoma; CD2 antigen; CD3 antigen; Immunohistochemistry; DNA nucleotidylexotransferase DO - http://dx.doi.org/10.1002/cyto.b.20442 ER - TY - JOUR T1 - Malaria sporozoite antigen-directed genome-wide response in transgenic Drosophila AN - 20480932; 9180608 AB - Malaria kills a million people annually. Understanding the relationship between a causative parasite, Plasmodium falciparum, and the mosquito vector might suggest novel prevention approaches. We created and transformed into Drosophila two genes encoding, thrombospondin-related adhesive protein (TRAP) and circumsporozoite protein (CSP), found on the cell surface of Plasmodium sporozoites. To understand a model insect's response, we induced these proteins separately and together, performing whole genome microarray analysis measuring gene expression changes. Gene ontology classification of responding genes reveals that TRAP and CSP strongly and differentially influence Drosophila genes involved with cell motility and gene regulation, respectively; however, the most striking effects are on the immune system. While immune-related genes are but modestly elevated compared with responses to sepsis, there is a marked repression of the Toll pathway. This suggests: (1) how Plasmodium infection of the mosquito might use TRAP and CSP to modulate the host insect's physiology to promote sporozoite survival and transmission to man and (2) that approaches to elevate expression of the mosquito's Toll pathway might lead to novel methods of malaria prevention. genesis 47:196-203, 2009. JF - Genesis AU - Yan, Jizhou AU - Yang, Xiang AU - Mortin, Mark A AU - Shahabuddin, Mohammed AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, jyan2@mail.med.upenn.edu Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 196 EP - 203 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 47 IS - 3 SN - 1526-954X, 1526-954X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Entomology Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Genomes KW - Parasites KW - Cell surface KW - Immune system KW - Transcription KW - Survival KW - Sporozoites KW - Malaria KW - Plasmodium falciparum KW - thrombospondin-related adhesive protein KW - Infection KW - DNA microarrays KW - Disease transmission KW - circumsporozoite protein KW - Sepsis KW - Gene regulation KW - Acid phosphatase (tartrate-resistant) KW - Cell migration KW - Drosophila KW - G 07720:Immunogenetics KW - W 30925:Genetic Engineering KW - K 03300:Methods KW - F 06900:Methods KW - Z 05360:Genetics and Evolution KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20480932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genesis&rft.atitle=Malaria+sporozoite+antigen-directed+genome-wide+response+in+transgenic+Drosophila&rft.au=Yan%2C+Jizhou%3BYang%2C+Xiang%3BMortin%2C+Mark+A%3BShahabuddin%2C+Mohammed&rft.aulast=Yan&rft.aufirst=Jizhou&rft.date=2009-03-01&rft.volume=47&rft.issue=3&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Genesis&rft.issn=1526954X&rft_id=info:doi/10.1002%2Fdvg.20483 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Cell surface; Parasites; Immune system; Sporozoites; Survival; Transcription; Malaria; thrombospondin-related adhesive protein; Infection; DNA microarrays; Disease transmission; circumsporozoite protein; Sepsis; Gene regulation; Acid phosphatase (tartrate-resistant); Cell migration; Plasmodium falciparum; Drosophila DO - http://dx.doi.org/10.1002/dvg.20483 ER - TY - JOUR T1 - Exposure to Mouse Allergen in U.S. Homes Associated with Asthma Symptoms AN - 20414751; 9089321 AB - BACKGROUND: Most studies investigating the role of residential mouse allergen exposures in asthma have focused on inner-city populations. Objective: We examined whether elevated mouse allergen levels were associated with occupants' asthma status in a nationally representative sample of U.S. households. Methods: Data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed 831 housing units inhabited by 2,456 individuals in 75 different locations throughout the United States. The survey obtained information on demographics, household characteristics, and occupants' health status by questionnaire and environmental observations. We used a polydonal immunoassay to assess concentrations of mouse urinary protein (MUP) in vacuumed dust collected from various indoor sites. RESULTS: Of the surveyed homes, 82% had detectable levels of MUP, and in 35% of the homes, MUP concentrations exceeded 1.6 kg/g, a level that has been associated with increased mouse allergen sensitization rates. Current asthma, defined as having doctor-diagnosed asthma and asthma symptoms in the preceding 12 months, was positively associated with increased MUP levels. The observed association was modified by atopic status; in allergic individuals, elevated MUP levels (> 1.6 kg/g) increased the odds of having asthma symptoms [adjusted OR = 1.93; 95% confidence interval (CI), 1.14-3.27], but we found no association in those who did not report allergies (adjusted OR = 0.69; 95% CI, 0.33-1.44). Conclusions: In allergic asthma, residential mouse allergen exposure is an important risk factor for asthma morbidity. JF - Environmental Health Perspectives AU - Salo, P M AU - Jaramillo, R AU - Cohn, R D AU - London, S J AU - Zeldin, D C AD - NIEHS/NIH, 111 Alexander Dr., Mail Drop D2-01, Research Triangle Park, NC 27709 USA, zeldin@niehs.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 387 EP - 391 VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Risk Abstracts; Immunology Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - demography KW - Housing KW - Respiratory diseases KW - Allergies KW - Dust KW - Morbidity KW - Lead KW - Demography KW - households KW - Hypersensitivity KW - Risk factors KW - Allergens KW - Inventories KW - Data processing KW - Asthma KW - USA KW - Atopy KW - Urine KW - Proteins KW - Immunoassays KW - F 06925:Hypersensitivity KW - R2 23060:Medical and environmental health KW - X 24360:Metals KW - H 12000:Epidemiology and Public Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20414751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+to+Mouse+Allergen+in+U.S.+Homes+Associated+with+Asthma+Symptoms&rft.au=Salo%2C+P+M%3BJaramillo%2C+R%3BCohn%2C+R+D%3BLondon%2C+S+J%3BZeldin%2C+D+C&rft.aulast=Salo&rft.aufirst=P&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11847 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inventories; Data processing; Housing; Asthma; Lead; Morbidity; Dust; Demography; Hypersensitivity; Atopy; Allergens; Risk factors; Immunoassays; demography; Respiratory diseases; Allergies; households; Urine; Proteins; USA DO - http://dx.doi.org/10.1289/ehp.11847 ER - TY - JOUR T1 - Modulation of spontaneous fMRI activity in human visual cortex by behavioral state AN - 20394681; 9066236 AB - The phenomenon of spontaneous fMRI activity is increasingly being exploited to investigate the connectivity of functional networks in human brain with high spatial-resolution. Although mounting evidence points towards a neuronal contribution to this activity, its functional role and dependence on behavioral state remain unclear. In this work, we used BOLD fMRI at 7 T to study the modulation of spontaneous activity in occipital areas by various behavioral conditions, including resting with eyes closed, eyes open with visual fixation, and eyes open with fixation and focal visual stimulation. Spontaneous activity was separated from evoked activity and from signal fluctuations related to cardiac and respiratory cycles. We found that spontaneous activity in visual areas was substantially reduced (amplitude (44%) and coherence (25%)) with the fixation conditions relative to the eyes-closed condition. No significant further modulation was observed when the visual stimulus was added. The observed dependence on behavioral condition suggests that part of spontaneous fMRI signal fluctuations represents neuronal activity. Possible mechanisms for the modulation of spontaneous activity by behavioral state are discussed. The observed linear superposition of spontaneous fMRI activity with focal evoked activity related to visual processing has important implications for fMRI studies, which ideally should take into account the effect of spontaneous activity to properly define brain activations during task conditions. JF - NeuroImage AU - Bianciardi, Marta AU - Fukunaga, Masaki AU - van Gelderen, Peter AU - Horovitz, Silvina G AU - de Zwart, Jacco A AU - Duyn, Jeff H AD - Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, bianciardim@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 160 EP - 168 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 45 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - 7 T BOLD fMRI KW - Evoked activity KW - Eyes open/closed KW - Spontaneous activity KW - Visual cortex KW - Visual stimuli KW - Heart KW - Brain mapping KW - Neural networks KW - Cortex (visual) KW - Functional magnetic resonance imaging KW - Information processing KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20394681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Modulation+of+spontaneous+fMRI+activity+in+human+visual+cortex+by+behavioral+state&rft.au=Bianciardi%2C+Marta%3BFukunaga%2C+Masaki%3Bvan+Gelderen%2C+Peter%3BHorovitz%2C+Silvina+G%3Bde+Zwart%2C+Jacco+A%3BDuyn%2C+Jeff+H&rft.aulast=Bianciardi&rft.aufirst=Marta&rft.date=2009-03-01&rft.volume=45&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.10.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Visual stimuli; Brain mapping; Cortex (visual); Neural networks; Information processing; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2008.10.034 ER - TY - JOUR T1 - ERP indices of persisting and current inhibitory control: A study of saccadic task switching AN - 20394297; 9066239 AB - Previous studies have found that inhibition of a biologically dominant prepotent response tendency is required during the execution of a less familiar, non-prepotent response. However, the lasting impact of this inhibition and the cognitive mechanisms to flexibly switch between prepotent and non-prepotent responses are poorly understood. We examined the neurophysiological (ERP) correlates of switching between prosaccade and antisaccade responses in 22 healthy volunteers. The behavioural data showed significant switch costs in terms of response latency for the prosaccade task only. These costs occurred exclusively in trials when preparation for the switch was limited to 300 ms, suggesting that inhibition of the prepotent prosaccade task either passively dissipated or was actively overcome during the longer 1000 ms preparation interval. In the neurophysiological data, a late frontal negativity (LFN) was visible during preparation for a switch to the prosaccade task that was absent when switching to the antisaccade task, which may reflect the overcoming of persisting inhibition. During task implementation both saccade types were associated with a late parietal positivity (LPP) for switch relative to repetition trials, possibly indicating attentional reorienting to the switched-to task, and visible only with short preparation intervals. When the prosaccade and antisaccade task were contrasted directly during task implementation, the antisaccade task exhibited increased stimulus-locked N2 and decreased P3 amplitudes indicative of active inhibition. The present findings indicate that neurophysiological markers of persisting and current inhibition can be revealed using a prosaccade/antisaccade-switching task. JF - NeuroImage AU - Mueller, S C AU - Swainson, R AU - Jackson, G M AD - School of Psychology, University of Nottingham, UK, msven@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 191 EP - 197 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 45 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Antisaccade KW - ERP KW - Cognitive control KW - Task switching KW - N2 KW - Saccadic eye movements KW - Repetition KW - Data processing KW - Cognitive ability KW - Attention KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20394297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=ERP+indices+of+persisting+and+current+inhibitory+control%3A+A+study+of+saccadic+task+switching&rft.au=Mueller%2C+S+C%3BSwainson%2C+R%3BJackson%2C+G+M&rft.aulast=Mueller&rft.aufirst=S&rft.date=2009-03-01&rft.volume=45&rft.issue=1&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.11.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Saccadic eye movements; Repetition; Data processing; Cognitive ability; Attention DO - http://dx.doi.org/10.1016/j.neuroimage.2008.11.019 ER - TY - JOUR T1 - Impact of interacting functional variants in COMT on regional gray matter volume in human brain AN - 20392215; 9066223 AB - Background Functional variants in the catechol-O-methyltransferase (COMT) gene have been shown to impact cognitive function, cortical physiology and risk for schizophrenia. A recent study showed that previously reported effects of the functional val158met SNP (rs4680) on brain function are modified by other functional SNPs and haplotypes in the gene, though it was unknown if these effects are also seen in brain structure. Methods We used voxel-based morphometry to investigate the impact of multiple functional variants in COMT on gray matter volume in a large group of 151 healthy volunteers from the CBDB/NIMH Genetic Study of Schizophrenia. Results We found that the previously described rs4680 val risk variant affects hippocampal and dorsolateral prefrontal (DLPFC) gray matter volume. In addition, we found that this SNP interacts with a variant in the P2 promoter region (rs2097603) in predicting changes in hippocampal gray matter volume consistent with a nonlinear effect of extracellular dopamine. Conclusions We report evidence that interacting functional variants in COMT affect gray matter regional volume in hippocampus and DLPFC, providing further in vivo validation of the biological impact of complex genetic variation in COMT on neural systems relevant for the pathophysiology of schizophrenia and extending observations of nonlinear dependence of prefrontal neurons on extracellular dopamine to the domain of human brain structure. JF - NeuroImage AU - Honea, Robyn AU - Verchinski, Beth A AU - Pezawas, Lukas AU - Kolachana, Bhaskar S AU - Callicott, Joseph H AU - Mattay, Venkata S AU - Weinberger, Daniel R AU - Meyer-Lindenberg, Andreas AD - Genes, Cognition and Psychosis Program, National Institute of Mental Health; Division of Intramural Research; National Institutes of Health; Department of Health and Human Services, Rm 4S-235, Bethesda, 20892, USA, Daniel.weinberger@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 44 EP - 51 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 45 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Hippocampus KW - Brain KW - Genetic diversity KW - Schizophrenia KW - Promoters KW - Mental disorders KW - Catechol O-methyltransferase KW - Dopamine KW - Haplotypes KW - Morphometry KW - Cognitive ability KW - Single-nucleotide polymorphism KW - Neurons KW - Substantia grisea KW - N3 11023:Neurogenetics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20392215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Impact+of+interacting+functional+variants+in+COMT+on+regional+gray+matter+volume+in+human+brain&rft.au=Honea%2C+Robyn%3BVerchinski%2C+Beth+A%3BPezawas%2C+Lukas%3BKolachana%2C+Bhaskar+S%3BCallicott%2C+Joseph+H%3BMattay%2C+Venkata+S%3BWeinberger%2C+Daniel+R%3BMeyer-Lindenberg%2C+Andreas&rft.aulast=Honea&rft.aufirst=Robyn&rft.date=2009-03-01&rft.volume=45&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.10.064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hippocampus; Brain; Genetic diversity; Schizophrenia; Promoters; Mental disorders; Dopamine; Catechol O-methyltransferase; Haplotypes; Single-nucleotide polymorphism; Cognitive ability; Morphometry; Neurons; Substantia grisea DO - http://dx.doi.org/10.1016/j.neuroimage.2008.10.064 ER - TY - JOUR T1 - Neural substrates of explicit and implicit fear memory AN - 20392136; 9066241 AB - Distinct aspects of our fearful experiences appear to be mediated by separate explicit and implicit memory processes. To identify brain regions that support these separate memory processes, we measured contingency awareness, conditional fear expression, and functional magnetic resonance imaging signal during a Pavlovian fear conditioning procedure in which tones that predicted an aversive event were presented at supra and sub-threshold volumes. Contingency awareness developed in conjunction with learning-related hippocampal and parahippocampal activity on perceived conditioning trials only. In contrast, conditional fear and differential amygdala activity developed on both perceived and unperceived trials, regardless of whether contingency awareness was expressed. These findings demonstrate the distinct roles of these brain regions in explicit and implicit fear memory processes. JF - NeuroImage AU - Knight, David C AU - Waters, Najah S AU - Bandettini, Peter A AD - Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA, knightdc@uab.edu Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 208 EP - 214 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 45 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Memory KW - Hippocampus KW - Functional magnetic resonance imaging KW - Amygdala KW - Fear conditioning KW - Contingency KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20392136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Neural+substrates+of+explicit+and+implicit+fear+memory&rft.au=Knight%2C+David+C%3BWaters%2C+Najah+S%3BBandettini%2C+Peter+A&rft.aulast=Knight&rft.aufirst=David&rft.date=2009-03-01&rft.volume=45&rft.issue=1&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.11.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Brain mapping; Memory; Hippocampus; Functional magnetic resonance imaging; Amygdala; Fear conditioning; Contingency DO - http://dx.doi.org/10.1016/j.neuroimage.2008.11.015 ER - TY - JOUR T1 - Pulsed High Intensity Focused Ultrasound Mediated Nanoparticle Delivery: Mechanisms and Efficacy in Murine Muscle AN - 20391022; 9067959 AB - High intensity focused ultrasound (HIFU) is generally thought to interact with biological tissues in two ways: hyperthermia (heat) and acoustic cavitation. Pulsed mode HIFU has recently been demonstrated to increase the efficacy of a variety of drug therapies. Generally, it is presumed that the treatment acts to temporarily increase the permeability of the tissue to the therapeutic agent, however, the precise mechanism remains in dispute. In this article, we present evidence precluding hyperthermia as a principal mechanism for enhancing delivery, using a quantitative analysis of systemically administered fluorescent nanoparticles delivered to muscle in the calves of mice. Comparisons were carried out on the degree of enhancement between an equivalent heat treatment, delivered without ultrasound, and that of the pulsed-HIFU itself. In the murine calf muscle, Pulsed-HIFU treatment resulted in a significant increase in distribution of 200 nm particles (p < 0.016, n = 6), while the equivalent thermal dose showed no significant increase. Additional studies using this tissue/agent model also demonstrated that the pulsed HIFU enhancing effects persist for more than 24 h, which is longer than that of hyperthermia and acoustic cavitation, and offers the possibility of a novel third mechanism for mediating delivery. JF - Ultrasound in Medicine & Biology AU - O'Neill, Brian E AU - Vo, Howard AU - Angstadt, Mary AU - Li, King P C AU - Quinn, Tim AU - Frenkel, Victor AD - Materials Reliability Division, National Institute of Standards and Technology, Boulder, CO, USA, vfrenkel@cc.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 416 EP - 424 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 35 IS - 3 SN - 0301-5629, 0301-5629 KW - Biotechnology and Bioengineering Abstracts KW - Permeability KW - Hyperthermia KW - Cavitation KW - Acoustics KW - Heat KW - Muscles KW - Heat treatments KW - Ultrasound KW - nanoparticles KW - Drugs KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20391022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Pulsed+High+Intensity+Focused+Ultrasound+Mediated+Nanoparticle+Delivery%3A+Mechanisms+and+Efficacy+in+Murine+Muscle&rft.au=O%27Neill%2C+Brian+E%3BVo%2C+Howard%3BAngstadt%2C+Mary%3BLi%2C+King+P+C%3BQuinn%2C+Tim%3BFrenkel%2C+Victor&rft.aulast=O%27Neill&rft.aufirst=Brian&rft.date=2009-03-01&rft.volume=35&rft.issue=3&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2008.09.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Permeability; Hyperthermia; Cavitation; Heat; Acoustics; Muscles; Heat treatments; Drugs; nanoparticles; Ultrasound; Models DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2008.09.021 ER - TY - JOUR T1 - The Bulgarian Emergency Response System for dose assessment in the early stage of accidental releases to the atmosphere AN - 20389171; 9064055 AB - The Bulgarian Emergency Response System (BERS) is being developed in the Bulgarian National Institute of Meteorology and Hydrology since 1994. BERS is based on numerical weather forecast meteorological information and a numerical long-range dispersion model accounting for the transport, dispersion, chemical and radioactive transformations of pollutants. In the present paper, the further development of this system for a mixture of radioactive gaseous and aerosol pollutants is described. The basic module for the BERS, the numerical dispersion model EMAP, is upgraded with a 'dose calculation block'. Two scenarios for hypothetical accidental atmospheric releases from two NPPs, one in Western, and the other in Eastern Europe, are numerically simulated. The effective doses from external irradiation, from air submersion and ground shinning, effective dose from inhalation and absorbed dose by thyroid gland formed by 37 different radionuclides, significant for the early stage of a nuclear accident, are calculated as dose fields for both case studies and discussed. JF - Journal of Environmental Radioactivity AU - Syrakov, D AU - Veleva, B AU - Prodanova, M AU - Popova, T AU - Kolarova, M AD - National Institute of Meteorology and Hydrology - Bulgarian Academy of Sciences (NIMH - BAS), Tsarigradsko chaussee 66, Sofia 1784, Bulgaria, blagorodka.veleva@meteo.bg Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 151 EP - 156 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 100 IS - 3 SN - 0265-931X, 0265-931X KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Atmospheric dispersion modeling KW - Radioactive releases KW - Nuclear accident KW - Dose assessment KW - Inhalation KW - Weather KW - Aerosols KW - Environmental radioactivity KW - Pollution dispersion KW - Thyroid KW - Meteorological information KW - Europe KW - Long-range dispersion models KW - Atmosphere KW - case studies KW - Accidents KW - Case studies KW - Irradiation KW - Emergency preparedness KW - Radioisotopes KW - Hydrology KW - Meteorology KW - Radioactive pollution dispersion KW - Dispersion models KW - Weather forecasting KW - Meteorological institutions KW - M2 551.510.42:Air Pollution (551.510.42) KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20389171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Radioactivity&rft.atitle=The+Bulgarian+Emergency+Response+System+for+dose+assessment+in+the+early+stage+of+accidental+releases+to+the+atmosphere&rft.au=Syrakov%2C+D%3BVeleva%2C+B%3BProdanova%2C+M%3BPopova%2C+T%3BKolarova%2C+M&rft.aulast=Syrakov&rft.aufirst=D&rft.date=2009-03-01&rft.volume=100&rft.issue=3&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Radioactivity&rft.issn=0265931X&rft_id=info:doi/10.1016%2Fj.jenvrad.2008.11.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Environmental radioactivity; Meteorological information; Hydrology; Radioactive pollution dispersion; Long-range dispersion models; Dispersion models; Weather forecasting; Meteorological institutions; Inhalation; Weather; Aerosols; Pollution dispersion; Thyroid; Atmosphere; case studies; Accidents; Case studies; Emergency preparedness; Irradiation; Radioisotopes; Meteorology; Europe DO - http://dx.doi.org/10.1016/j.jenvrad.2008.11.002 ER - TY - JOUR T1 - Sonographic evaluation in the second stage of labor to improve the assessment of labor progress and its outcome AN - 20387649; 9059086 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Yeo, Lami AU - Romero, Roberto AD - Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, MD and Detroit, MI, Wayne State University, Detroit, MI, USA, prbchiefstaff@med.wayne.edu Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 253 EP - 258 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 33 IS - 3 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Gynecology KW - Obstetrics KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20387649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Sonographic+evaluation+in+the+second+stage+of+labor+to+improve+the+assessment+of+labor+progress+and+its+outcome&rft.au=Yeo%2C+Lami%3BRomero%2C+Roberto&rft.aulast=Yeo&rft.aufirst=Lami&rft.date=2009-03-01&rft.volume=33&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.6336 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gynecology; Ultrasound; Obstetrics DO - http://dx.doi.org/10.1002/uog.6336 ER - TY - JOUR T1 - The Yersinia pestis caf1M1A1 Fimbrial Capsule Operon Promotes Transmission by Flea Bite in a Mouse Model of Bubonic Plague AN - 20387392; 9065367 AB - Plague is a zoonosis transmitted by fleas and caused by the gram-negative bacterium Yersinia pestis. During infection, the plasmidic caf1M1A1 operon that encodes the Y. pestis F1 protein capsule is highly expressed, and anti-F1 antibodies are protective. Surprisingly, the capsule is not required for virulence after injection of cultured bacteria, even though it is an antiphagocytic factor and capsule-deficient Y. pestis strains are rarely isolated. We found that a caf-negative Y. pestis mutant was not impaired in either flea colonization or virulence in mice after intradermal inoculation of cultured bacteria. In contrast, absence of the caf operon decreased bubonic plague incidence after a flea bite. Successful development of plague in mice infected by flea bite with the caf-negative mutant required a higher number of infective bites per challenge. In addition, the mutant displayed a highly autoaggregative phenotype in infected liver and spleen. The results suggest that acquisition of the caf locus via horizontal transfer by an ancestral Y. pestis strain increased transmissibility and the potential for epidemic spread. In addition, our data support a model in which atypical caf-negative strains could emerge during climatic conditions that favor a high flea burden. Human infection with such strains would not be diagnosed by the standard clinical tests that detect F1 antibody or antigen, suggesting that more comprehensive surveillance for atypical Y. pestis strains in plague foci may be necessary. The results also highlight the importance of studying Y. pestis pathogenesis in the natural context of arthropod-borne transmission. JF - Infection and Immunity AU - Sebbane, Florent AU - Jarrett, Clayton AU - Gardner, Donald AU - Long, Daniel AU - Hinnebusch, BJoseph AD - Laboratory of Zoonotic Pathogens. Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana. Institut National de la Sante et de la Recherche Medicale, U801, Institut Pasteur de Lille, Universite de Lille 2, Lille, France Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 1222 EP - 1229 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 77 IS - 3 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Epidemics KW - Data processing KW - Bites KW - Animal models KW - Yersinia pestis KW - Spleen KW - Infection KW - Climatic conditions KW - Horizontal transfer KW - Virulence KW - Colonization KW - Antibodies KW - Liver KW - Inoculation KW - Plague KW - Operons KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20387392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+Yersinia+pestis+caf1M1A1+Fimbrial+Capsule+Operon+Promotes+Transmission+by+Flea+Bite+in+a+Mouse+Model+of+Bubonic+Plague&rft.au=Sebbane%2C+Florent%3BJarrett%2C+Clayton%3BGardner%2C+Donald%3BLong%2C+Daniel%3BHinnebusch%2C+BJoseph&rft.aulast=Sebbane&rft.aufirst=Florent&rft.date=2009-03-01&rft.volume=77&rft.issue=3&rft.spage=1222&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Epidemics; Bites; Animal models; Spleen; Infection; Climatic conditions; Horizontal transfer; Virulence; Colonization; Antibodies; Inoculation; Liver; Plague; Operons; Yersinia pestis ER - TY - JOUR T1 - Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells AN - 20376040; 9057056 AB - We hypothesized that chlorophyllin (CHLN) would reduce benzo[a]pyrene-DNA (BP-DNA) adduct levels. Using normal human mammary epithelial cells (NHMECs) exposed to 4 M BP for 24 hr in the presence or absence of 5 M CHLN, we measured BP-DNA adducts by chemiluminescence immunoassay (CIA). The protocol included the following experimental groups: BP alone, BP given simultaneously with CHLN (BP+CHLN) for 24 hr, CHLN given for 24 hr followed by BP for 24 hr (preCHLN, postBP), and CHLN given for 48 hr with BP added for the last 24 hr (preCHLN, postBP+CHLN). Incubation with CHLN decreased BPdG levels in all groups, with 87% inhibition in the preCHLN, postBP+CHLN group. To examine metabolic mechanisms, we monitored expression by Affymetrix microarray (U133A), and found BP-induced up-regulation of CYP1A1 and CYP1B1 expression, as well as up-regulation of groups of interferon-inducible, inflammation and signal transduction genes. Incubation of cells with CHLN and BP in any combination decreased expression of many of these genes. Using reverse transcription real time PCR (RT-PCR) the maximal inhibition of BP-induced gene expression, >85% for CYP1A1 and >70% for CYP1B1, was observed in the preCHLN, postBP+CHLN group. To explore the relationship between transcription and enzyme activity, the ethoxyresorufin-O-deethylase (EROD) assay was used to measure the combined CYP1A1 and CYP1B1 activities. BP exposure caused the EROD levels to double, when compared with the unexposed controls. The CHLN-exposed groups all showed EROD levels similar to the unexposed controls. Therefore, the addition of CHLN to BP-exposed cells reduced BPdG formation and CYP1A1 and CYP1B1 expression, but EROD activity was not significantly reduced. JF - Environmental and Molecular Mutagenesis AU - Keshava, Channa AU - Divi, Rao L AU - Einem, Tracey L AU - Richardson, Diana L AU - Leonard, Sarah L AU - Keshava, Nagalakshmi AU - Poirier, Miriam C AU - Weston, Ainsley AD - Molecular Carcinogenesis Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, poirierm@exchange.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 134 EP - 144 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 50 IS - 2 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Adducts KW - Cytochrome P450 KW - G 07720:Immunogenetics KW - N 14810:Methods KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20376040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Chlorophyllin+significantly+reduces+benzo%5Ba%5Dpyrene-DNA+adduct+formation+and+alters+cytochrome+P450+1A1+and+1B1+expression+and+EROD+activity+in+normal+human+mammary+epithelial+cells&rft.au=Keshava%2C+Channa%3BDivi%2C+Rao+L%3BEinem%2C+Tracey+L%3BRichardson%2C+Diana+L%3BLeonard%2C+Sarah+L%3BKeshava%2C+Nagalakshmi%3BPoirier%2C+Miriam+C%3BWeston%2C+Ainsley&rft.aulast=Keshava&rft.aufirst=Channa&rft.date=2009-03-01&rft.volume=50&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20449 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Cytochrome P450 DO - http://dx.doi.org/10.1002/em.20449 ER - TY - JOUR T1 - Enhanced antibody responses to Plasmodium falciparum Pfs28 induced in mice by conjugation to ExoProtein A of Pseudomonas aeruginosa with an improved procedure AN - 20170245; 10254949 AB - In this paper we report our efforts to enhance the immunogenicity of Pfs28, a transmission blocking vaccine candidate of Plasmodium falciparum, using a strategy of chemical conjugation. With an improved procedure, Pfs28 was covalently coupled to the mutant and non-toxic ExoProtein A of Pseudomonas aeruginosa by the reaction between thiolated antigen and maleimide modified carrier protein. The optimized process resulted in a higher antigen-carrier conjugation ratio, and the conjugation product could be purified using single-step size-exclusion chromatography. A significant increase in immunogenicity measured by ELISA was observed in mice immunized with conjugated Pfs28 as compared to unconjugated Pfs28. JF - Microbes and Infection AU - Qian, Feng AU - Aebig, Joan A AU - Reiter, Karine AU - Barnafo, Emma AU - Zhang, Yanling AU - Shimp, Richard L AU - Rausch, Kelly M AU - Jones, David S AU - Zhu, Daming AU - Lambert, Lynn AU - Mullen, Gregory ED AU - Narum, David L AU - Miller, Louis H AU - Wu, Yimin AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA, fqian_cn@hotmail.com Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 408 EP - 412 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France, [URL:http://www.elsevier.fr] VL - 11 IS - 3 SN - 1286-4579, 1286-4579 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Conjugation KW - Pfs28 KW - rEPA KW - Malaria KW - Transmission blocking vaccine KW - Antibodies KW - Enzyme-linked immunosorbent assay KW - Immunogenicity KW - Chromatography KW - Plasmodium falciparum KW - Vaccines KW - Pseudomonas aeruginosa KW - K 03350:Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20170245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Enhanced+antibody+responses+to+Plasmodium+falciparum+Pfs28+induced+in+mice+by+conjugation+to+ExoProtein+A+of+Pseudomonas+aeruginosa+with+an+improved+procedure&rft.au=Qian%2C+Feng%3BAebig%2C+Joan+A%3BReiter%2C+Karine%3BBarnafo%2C+Emma%3BZhang%2C+Yanling%3BShimp%2C+Richard+L%3BRausch%2C+Kelly+M%3BJones%2C+David+S%3BZhu%2C+Daming%3BLambert%2C+Lynn%3BMullen%2C+Gregory+ED%3BNarum%2C+David+L%3BMiller%2C+Louis+H%3BWu%2C+Yimin&rft.aulast=Qian&rft.aufirst=Feng&rft.date=2009-03-01&rft.volume=11&rft.issue=3&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2Fj.micinf.2008.12.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Antibodies; Chromatography; Immunogenicity; Vaccines; Plasmodium falciparum; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1016/j.micinf.2008.12.009 ER - TY - JOUR T1 - Individual versus Household Migration Decision Rules: Gender and Marital Status Differences in Intentions to Migrate in South Africa AN - 20052630; 9160387 AB - AbstractThis research tests the thesis that the neoclassical microeconomic and the new household economic theoretical assumptions on migration decision-making rules are segmented by gender, marital status, and time frame of intention to migrate. Comparative tests of both theories within the same study design are relatively rare. Utilizing data from the Causes of Migration in South Africa national migration survey, we analyse how individually held 'own-future' versus alternative 'household well-being' migration decision rules effect the intentions to migrate of male and female adults in South Africa. Results from the gender and marital status specific logistic regressions models show consistent support for the different gender-marital status decision rule thesis. Specifically, the 'maximizing one's own future' neoclassical microeconomic theory proposition is more applicable for never married men and women, the 'maximizing household income' proposition for married men with short-term migration intentions, and the 'reduce household risk' proposition for longer time horizon migration intentions of married men and women. Results provide new evidence on the way household strategies and individual goals jointly affect intentions to move or stay. JF - International Migration AU - Gubhaju, Bina AU - De Jong, Gordon F AD - *Bina Gubhaju, Asia Research Institute, National University of Singapore and Gordon F. De Jong, Department of Sociology and the Population Research Institute, Pennsylvania State University. We acknowledge the Human Sciences Research Council, Government of South Africa, and Dr. Pieter Kok for providing access to the data used in this study. Partial support for the analysis was provided by a centre support grant to the Pennsylvania State University Population Research Institute from the National Institute of Child Health and Human Development (grant No. 1R24HD41025). An earlier version of this paper was presented at the 2005 Population Association of America. Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 31 EP - 61 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 47 IS - 1 SN - 0020-7985, 0020-7985 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20052630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Migration&rft.atitle=Individual+versus+Household+Migration+Decision+Rules%3A+Gender+and+Marital+Status+Differences+in+Intentions+to+Migrate+in+South+Africa&rft.au=Gubhaju%2C+Bina%3BDe+Jong%2C+Gordon+F&rft.aulast=Gubhaju&rft.aufirst=Bina&rft.date=2009-03-01&rft.volume=47&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=International+Migration&rft.issn=00207985&rft_id=info:doi/10.1111%2Fj.1468-2435.2008.00496.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1111/j.1468-2435.2008.00496.x ER -